Guide to the Human Genome
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Search of human proteins with 195232763

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|195232763 ADAM metallopeptidase domain 29 preproprotein
[Homo sapiens]
         (820 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo...  1767   0.0  
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo...  1767   0.0  
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo...  1767   0.0  
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ...  1767   0.0  
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ...   810   0.0  
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ...   782   0.0  
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H...   515   e-146
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ...   491   e-138
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot...   363   e-100
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ...   361   2e-99
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot...   355   1e-97
gi|148664238 a disintegrin and metalloprotease domain 32 [Homo s...   337   3e-92
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi...   335   8e-92
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ...   314   2e-85
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot...   309   6e-84
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro...   306   5e-83
gi|7656861 a disintegrin and metalloprotease domain 18 prepropro...   306   5e-83
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]   291   2e-78
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop...   288   1e-77
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor...   275   2e-73
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor...   273   4e-73
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor...   271   2e-72
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor...   268   1e-71
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor...   268   2e-71
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s...   260   4e-69
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot...   258   1e-68
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot...   258   1e-68
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot...   258   1e-68
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot...   258   1e-68
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote...   258   1e-68

>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score = 1767 bits (4576), Expect = 0.0
 Identities = 820/820 (100%), Positives = 820/820 (100%)

Query: 1   MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
           MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG
Sbjct: 1   MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60

Query: 61  QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
           QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF
Sbjct: 61  QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120

Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
           GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180

Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
           DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG
Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240

Query: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300
           VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI
Sbjct: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300

Query: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360
           GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN
Sbjct: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360

Query: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420
           PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA
Sbjct: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420

Query: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480
           KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY
Sbjct: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480

Query: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540
           VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT
Sbjct: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540

Query: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600
           YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD
Sbjct: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600

Query: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660
           GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG
Sbjct: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660

Query: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720
           SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK
Sbjct: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720

Query: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780
           IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP
Sbjct: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780

Query: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820
           VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS
Sbjct: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820


>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score = 1767 bits (4576), Expect = 0.0
 Identities = 820/820 (100%), Positives = 820/820 (100%)

Query: 1   MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
           MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG
Sbjct: 1   MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60

Query: 61  QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
           QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF
Sbjct: 61  QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120

Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
           GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180

Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
           DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG
Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240

Query: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300
           VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI
Sbjct: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300

Query: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360
           GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN
Sbjct: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360

Query: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420
           PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA
Sbjct: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420

Query: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480
           KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY
Sbjct: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480

Query: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540
           VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT
Sbjct: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540

Query: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600
           YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD
Sbjct: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600

Query: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660
           GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG
Sbjct: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660

Query: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720
           SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK
Sbjct: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720

Query: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780
           IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP
Sbjct: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780

Query: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820
           VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS
Sbjct: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820


>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score = 1767 bits (4576), Expect = 0.0
 Identities = 820/820 (100%), Positives = 820/820 (100%)

Query: 1   MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
           MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG
Sbjct: 1   MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60

Query: 61  QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
           QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF
Sbjct: 61  QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120

Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
           GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180

Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
           DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG
Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240

Query: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300
           VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI
Sbjct: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300

Query: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360
           GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN
Sbjct: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360

Query: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420
           PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA
Sbjct: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420

Query: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480
           KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY
Sbjct: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480

Query: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540
           VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT
Sbjct: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540

Query: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600
           YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD
Sbjct: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600

Query: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660
           GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG
Sbjct: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660

Query: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720
           SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK
Sbjct: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720

Query: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780
           IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP
Sbjct: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780

Query: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820
           VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS
Sbjct: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820


>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score = 1767 bits (4576), Expect = 0.0
 Identities = 820/820 (100%), Positives = 820/820 (100%)

Query: 1   MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
           MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG
Sbjct: 1   MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60

Query: 61  QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
           QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF
Sbjct: 61  QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120

Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
           GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180

Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
           DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG
Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240

Query: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300
           VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI
Sbjct: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300

Query: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360
           GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN
Sbjct: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360

Query: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420
           PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA
Sbjct: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420

Query: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480
           KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY
Sbjct: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480

Query: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540
           VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT
Sbjct: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540

Query: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600
           YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD
Sbjct: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600

Query: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660
           GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG
Sbjct: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660

Query: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720
           SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK
Sbjct: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720

Query: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780
           IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP
Sbjct: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780

Query: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820
           VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS
Sbjct: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820


>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
           sapiens]
          Length = 776

 Score =  810 bits (2091), Expect = 0.0
 Identities = 378/718 (52%), Positives = 488/718 (67%), Gaps = 11/718 (1%)

Query: 1   MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
           +++ LLL   G+FLS SGH Q    QY + P+VVIP+++    RG   PGWLSY L FGG
Sbjct: 60  IRVTLLLLWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGG 119

Query: 61  QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
           Q++I+H++V KLLF+ HLPVFTYT+Q A+L+DQPF+Q++CYYHGYVEG PESLV+LSTC 
Sbjct: 120 QRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCS 179

Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
           GGF G+LQIND  YEIKP++ S TFEHLVYK+DS++ QF  MR G  + +I  +ME +  
Sbjct: 180 GGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLS 239

Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
            N T KQSS+VGWW H R VE+VVV+DN  Y+  + N + +  +++ +VNIVDS    + 
Sbjct: 240 YNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLE 299

Query: 241 VKVLLFGLEIWTNKN-LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFT--TLGLRGL 297
           V V+L G++IWT  N L    D+   +  +  WK+ N+  R+QHD +HLF   T G++  
Sbjct: 300 VDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMK-- 357

Query: 298 SGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMH 357
            G+   +G+C    +  +  F +  L  F+I + H LGHNLGM HD   C C    CIMH
Sbjct: 358 LGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVCELQWCIMH 417

Query: 358 EGNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLK 417
                 TKFSNCSY  +W+ T+    C+    +  +IF +K CGN VVEEGEECDCG ++
Sbjct: 418 AYRKVTTKFSNCSYAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIR 477

Query: 418 HCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPD 477
            CAKDPCCL NCTL  G+ CAFG+CCKDCKFLPSG +CR++V ECDLPEWCNGTSH+CPD
Sbjct: 478 QCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPD 537

Query: 478 DFYVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIK 537
           D YV+DGI C    +CYEK+C++ + QC+ IFG  A +AS++CY+E+NT G+R GHCGI 
Sbjct: 538 DVYVQDGISCNVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIV 597

Query: 538 NATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597
             TY+KC   D+ CGR+QCENV  IPN+ +H+TV     ND  CW TDYHLGM  PDIGE
Sbjct: 598 GTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIPDIGE 657

Query: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657
           VKDGT CG + ICI + C  +  L+  C P  CN RGICNNK HCHCN+ W PP C  KG
Sbjct: 658 VKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAPPYCKDKG 717

Query: 658 YGGSVDSGPPPKRKKK-----KKFCYLCILLLIVLF-ILLCCLYRLCKKSKPIKKQQD 709
           YGGS DSGPPPK   +      K  YL +L L+ L   LL CL+ L KK    K+ ++
Sbjct: 718 YGGSADSGPPPKNNMEGLNVMGKLRYLSLLCLLPLVAFLLFCLHVLFKKRTKSKEDEE 775


>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
           sapiens]
          Length = 722

 Score =  782 bits (2019), Expect = 0.0
 Identities = 357/711 (50%), Positives = 481/711 (67%), Gaps = 9/711 (1%)

Query: 1   MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
           +++ LLL  LGVFLS SG+ Q    Q+ + P+VVIP+++    R    PGWLSY L FGG
Sbjct: 10  IRVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYSLRFGG 69

Query: 61  QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
           QKH++H++VKKLL S+HLPVFTYTD+ A+LEDQ F+ ++CYYHGYVEG PESLV  S CF
Sbjct: 70  QKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPESLVVFSACF 129

Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCR-MEFEE 179
           GGF+G+L+I+   YEI+P+  S TFEHLVYK++S E QF  MR G  + E+  + +EFEE
Sbjct: 130 GGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQLEFEE 189

Query: 180 IDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVI 239
            +NS  +  S   WW H   +E+VVV+++  +I  + N SK+ ED++++VNIVDS+   +
Sbjct: 190 AENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQL 249

Query: 240 GVKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSG 299
           G  ++L G+EIW   N+  +  + + ++ + +WK  +++ ++QHD +H+F    L  + G
Sbjct: 250 GTYIILIGIEIWNQGNVFPMTSIEQVLNDFSQWKQISLS-QLQHDAAHMFIKNSLISILG 308

Query: 300 IGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEG 359
           +    G+C P   C +  F   T   F+  VAH LGH LGM HDE+ C C +  CIM+  
Sbjct: 309 LAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFCGERGCIMNTF 368

Query: 360 NPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHC 419
             P  KF+NCSY DF + T+ +  CL       +IF +KRCGNGVVE  E+CDCG ++ C
Sbjct: 369 RVPAEKFTNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQC 428

Query: 420 AKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDF 479
            +D CCL NCTL  G+ CAFGLCCKDCKF+PSG++CR+EVNECDLPEWCNGTSH+CP+D 
Sbjct: 429 EQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDR 488

Query: 480 YVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNA 539
           YV+DGIPC +  YCY+K C++ ++ CR IFG  A +AS+ CYKE+N+ G+R GHCGI   
Sbjct: 489 YVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGT 548

Query: 540 TYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVK 599
           TY+KC+ISDV CGR+QCENV +IP + DH T+     N + CW  DYHL M   DIGEVK
Sbjct: 549 TYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMNISDIGEVK 608

Query: 600 DGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYG 659
           DGT CG   ICIH+ CV +++L+  C P  CN +GICNNKHHCHC Y W PP C  +GYG
Sbjct: 609 DGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYG 668

Query: 660 GSVDSGPPPKRKKKKKFCYLCIL----LLIVLFILLCCLY-RLCKKSKPIK 705
           GS+DSG  P   K+  F  L ++    +L  LF +   +Y R C   K  K
Sbjct: 669 GSIDSG--PASAKRGVFLPLIVIPSLSVLTFLFTVGLLMYLRQCSGPKETK 717


>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
           sapiens]
          Length = 819

 Score =  515 bits (1326), Expect = e-146
 Identities = 281/803 (34%), Positives = 430/803 (53%), Gaps = 30/803 (3%)

Query: 1   MKMLLLLHCLGVFLSCS--GHIQDEHPQYHSPPDVVIPVRITGTTRGMTPP--GWLSYIL 56
           ++ LLLL  +G  L  +  G  Q  H   +   +++ P R+T   R    P    +SY++
Sbjct: 14  VRWLLLLGLVGPVLGAARPGFQQTSHLSSY---EIITPWRLTRERREAPRPYSKQVSYVI 70

Query: 57  PFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSL 116
              G++HIIH++  K L  +   V+TY  +G ++ D P +QN+C+Y GYVEG   S ++L
Sbjct: 71  QAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIAL 130

Query: 117 STCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---TC 173
           S CFG  +G+L + + +Y I+PL  S+ FEH++Y+MD   K+   ++ G    +I   T 
Sbjct: 131 SDCFG-LRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKE--PLKCGVSNKDIEKETA 187

Query: 174 RMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVD 233
           + E EE  + TQ            R VE+ +V+D   Y    RN + + E++ ++ N +D
Sbjct: 188 KDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLD 247

Query: 234 SILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTL 292
           S+  ++ ++++L GLEIWTN NLI +V      +  + +W+ + +  R +HD++ L    
Sbjct: 248 SMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKK 307

Query: 293 GLRGLSGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDT-CRCSQ 351
           G  G +G+     +C+   +  I  F   T+ TF+  VAH LGHNLGMNHD+   C C  
Sbjct: 308 GFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGA 367

Query: 352 PRCIMHEGNPPITKFSNCSYGDFWEYTVERT-KCLLETVHTKDIFNVKRCGNGVVEEGEE 410
             CIM+ G      FS+CS  DF + T+ +   CLL      + ++   CGN +V+ GEE
Sbjct: 368 KSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEE 427

Query: 411 CDCGPLKHCAKDPCCL-SNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCN 469
           CDCG  K C  DPCC  S C L   + CA+G CCKDC+FLP G +CR + +ECD+PE+CN
Sbjct: 428 CDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCN 487

Query: 470 GTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLG 528
           G+S  C  D ++++G PC+  + YCY   C   + QC+ IFG+ A  A + C+ E+N+ G
Sbjct: 488 GSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKG 547

Query: 529 DRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHL 588
           DR G+CG     Y KC   +  CG++QCENV EIP       +         CW  D+ L
Sbjct: 548 DRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQL 607

Query: 589 GMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCS-PAFCNKRGICNNKHHCHCNYL 647
           G   PD G V +GT+CG   IC +  CV  ++LN +C     C+  G+CN+  +CHC   
Sbjct: 608 GSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENG 667

Query: 648 WDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCK-----KSK 702
           W PPNC  KGYGGSVDSGP            L +   +++ +++C ++   K     +S 
Sbjct: 668 WAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSY 727

Query: 703 PIKKQQDVQTPSAKEEEKIQRRPHELP----PQSQPWVMPSQSQPPVTPSQS--HPQVMP 756
             KK+        K +    R+P  +P    P + P  +P  +     P+ +   PQ  P
Sbjct: 728 FRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAAKQPQQFP 787

Query: 757 SQSQPPVTPSQSQPRVMPSQSQP 779
           S+  PP     SQ  ++P++  P
Sbjct: 788 SRPPPPQPKVSSQGNLIPARPAP 810


>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
           sapiens]
          Length = 790

 Score =  491 bits (1263), Expect = e-138
 Identities = 267/793 (33%), Positives = 432/793 (54%), Gaps = 33/793 (4%)

Query: 4   LLLLHCLGVFLSCSGHIQDEHPQYHSPP-DVVIPVRIT--GTTRGMTPPGWLSYILPFGG 60
           LLLL    + L   G     HP+      +V IP +++  G  +G+  P  +SY+L   G
Sbjct: 13  LLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSP--VSYLLQLKG 70

Query: 61  QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
           +KH++H+  K+LL  +HL VF++T+ G +LED P++  +C Y G V+   +S  ++STC 
Sbjct: 71  KKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCM 130

Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
           GG +G+  I+   Y+I+PL  S +FEH+VY +  E  QF     G   +EI  +M   E 
Sbjct: 131 GGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKE--QFGNQVCGLSDDEIEWQMAPYE- 187

Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
             +  +   + G + H + +E++++ D   Y     N S+++ D  ++  I+D+    + 
Sbjct: 188 --NKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVR 245

Query: 241 VKVLLFGLEIWTNKNLIVVD--DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS 298
           +++ L  LE+WT+ N I V   ++ + +  +  +K   +  R+  D +HL+         
Sbjct: 246 MRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDAL 305

Query: 299 GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRC-SQPRCIMH 357
              +F  +C+   + ++ T ++  +   +   AH LGH +GM+HDE  C+C  +  CIM 
Sbjct: 306 A-WSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLNCIMG 364

Query: 358 EGNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLK 417
            G    T FSNCSY  F+++      CL        +  +KRCGN +VE+ EECDCG  +
Sbjct: 365 SGR---TGFSNCSYISFFKHISSGATCLNNIPGLGYV--LKRCGNKIVEDNEECDCGSTE 419

Query: 418 HCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPD 477
            C KD CC SNC L  G+ C+ GLCC DC+F PSG VCR+E NECDL E+C+G S  CP+
Sbjct: 420 ECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPN 479

Query: 478 DFYVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHC--- 534
           D Y +DG PCK  G C+ K C  R  QC+ IFG  A  A   CY  +N +GD+ G+C   
Sbjct: 480 DVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEIT 539

Query: 535 GIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTV--HWARFNDIMCWSTDYHLGMKG 592
           GI+N  + KC  ++  CGR+QC NV  IP++ +HTT+     +  ++MCW T YHL MK 
Sbjct: 540 GIRN--FKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKP 597

Query: 593 ---PDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWD 649
              PD+G + DGT CG   +C  ++CV+ ++L  +C P  CN RG+CNN+ +CHC Y W 
Sbjct: 598 MGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWA 657

Query: 650 PPNCLIKGYGGSVDSGPPP--KRKKKKKFCYLCILLLIVLFILLCCLYRLCKK--SKPIK 705
           PP C   GYGGS+DSGPP   +         + I++  ++ ++L  ++   ++     +K
Sbjct: 658 PPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLK 717

Query: 706 KQQDVQTPSAKEEEKIQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTP 765
            +Q+    S  + E+ + +   +  +S+      +S+      +S  +    +S+  +  
Sbjct: 718 PKQEKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIES 777

Query: 766 SQSQPRVMPSQSQ 778
            + + + +  Q +
Sbjct: 778 KRPKAKSVKKQKK 790


>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
           [Homo sapiens]
          Length = 909

 Score =  363 bits (931), Expect = e-100
 Identities = 246/850 (28%), Positives = 396/850 (46%), Gaps = 88/850 (10%)

Query: 32  DVVIPVRITGTTRGMTPPGWLSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQG---A 88
           D+ IPV+   +      P  L+  L    ++ II+++  + L +       Y   G   +
Sbjct: 51  DLWIPVK---SFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVS 107

Query: 89  ILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHL 148
           +  +   +  +CYYHG+V G  +S VSLSTC  G +G++   + +Y ++P+  +T     
Sbjct: 108 LARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFENESYVLEPMKSATN---- 162

Query: 149 VYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI------------DNSTQKQSSYVGWWIH 196
            YK+    K+  ++R     +  T  +  + +               T K + Y      
Sbjct: 163 RYKL-FPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKY------ 215

Query: 197 FRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKN- 255
              VE+V+V DN  + R  ++  K+ + L  I N VD     + ++++L G+E+W + + 
Sbjct: 216 ---VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDK 272

Query: 256 LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCA 314
             V  D   S+H +  W+   + PR  HD + L + +  +G + G+     MCT  +S  
Sbjct: 273 CSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGG 332

Query: 315 IVTFMNKTLGTFSIAVAHHLGHNLGMNHD--EDTCRC----SQPRCIMH--EGNPPITKF 366
           IV   +      ++ +AH LGHN GMNHD  +  C C     +  CIM+   G P    F
Sbjct: 333 IVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVF 392

Query: 367 SNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC 424
           S+CS  D  E ++E+    CL      ++ F  ++CGN  VEEGEECDCG  + C    C
Sbjct: 393 SSCSRKDL-ETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCC 451

Query: 425 CLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDG 484
             + CTL   + CA GLCC+DC+  P+G  CR   N CDLPE+C G S  CP + Y+ DG
Sbjct: 452 NATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDG 511

Query: 485 IPCKE-RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCG-IKNATYI 542
             C++  GYCY   C    +QC  ++G GA  A   C++ +N+ GD  G+CG +  +++ 
Sbjct: 512 HSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFA 571

Query: 543 KCNISDVQCGRIQCENVTEIP-----NMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597
           KC + D +CG+IQC+     P      +S  T +   +   I+C  T  +LG   PD G 
Sbjct: 572 KCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGL 631

Query: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657
           V  GT+C    IC++R C +I++   +     C+ RG+CNN+ +CHC   W PP C   G
Sbjct: 632 VLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFG 691

Query: 658 YGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLY---------------------- 695
           +GGS DSGP  +   +     L I +L+ +  LL   +                      
Sbjct: 692 FGGSTDSGPIRQADNQG----LTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIE 747

Query: 696 --RLCKKSKPIKKQQDVQTPSAKEEEKIQRRPHE-LPPQSQP-WVMPSQSQPPVTPSQSH 751
             R  + S+P +  Q  Q       + + R+P +  PP+  P  ++  Q+     P    
Sbjct: 748 KLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGL 807

Query: 752 PQVMPSQSQPPVTPSQSQPR-----VMPSQSQPPVMPSQSHPQLTPSQSQPPVTPSQRQP 806
               P  +Q  + P    PR       P  ++P +  +Q   +  P Q   P  P  R  
Sbjct: 808 NVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTT 867

Query: 807 QLMPSQSQPP 816
           +L  + ++ P
Sbjct: 868 RLTHALARTP 877


>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
           sapiens]
          Length = 918

 Score =  361 bits (926), Expect = 2e-99
 Identities = 244/821 (29%), Positives = 386/821 (47%), Gaps = 70/821 (8%)

Query: 60  GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119
           G++ I+ ++  + LF+       YT  G        ++++C+YHG V     S V+LSTC
Sbjct: 73  GRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTC 132

Query: 120 FGGFQGILQIN-DFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFE 178
             G +G++ ++ + +Y I+PL  S   +HL+Y+  SE  +      GF  ++ T R    
Sbjct: 133 -RGIRGLITVSSNLSYVIEPLPDSKG-QHLIYR--SEHLKPPPGNCGFEHSKPTTRDWAL 188

Query: 179 EIDNSTQKQSSYVGW--WIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL 236
           +    T+K+   +        + VE+ +V D   + +  R+       L  I N VD   
Sbjct: 189 QFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFY 248

Query: 237 DVIGVKVLLFGLEIWTNKNLIVV-DDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLR 295
             + +++ L GLE+WT+ N+  V ++   ++  +  W+ + +  +  HD + L T +   
Sbjct: 249 RSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKY-HDNAQLITGMSFH 307

Query: 296 GLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPR- 353
           G + G+     MC+ ++S  +    ++     +  +AH +GHN GM HD   C CS    
Sbjct: 308 GTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADC-CSASAA 366

Query: 354 ---CIMHE--GNPPITKFSNCSYGDFWEYTVERT-KCLLETVHTKDIFNVKRCGNGVVEE 407
              CIM    G+P    F+ C+  +   Y       CL     T+ ++  +RCGNG +E+
Sbjct: 367 DGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLED 426

Query: 408 GEECDCGPLKHCAKDPCC-LSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPE 466
           GEECDCG  + C  +PCC  SNCTL  G+ CA G CC  CK L  G +CR++  +CDLPE
Sbjct: 427 GEECDCGEEEEC-NNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDLPE 485

Query: 467 WCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELN 525
           +C G S  CP +FY  DG PC+  + YCY   C    EQC++++G GA  A + C++++N
Sbjct: 486 FCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVN 545

Query: 526 TLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWA---RFNDIMC 581
             GD  G+CG   N  + KCN+ D +CG+IQC++    P  S+   +          I C
Sbjct: 546 VAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQC 605

Query: 582 WSTDYHLGMKGP----DIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICN 637
             T  + G +      D G V  GT+CG +HIC    C + +   +      CN  G+CN
Sbjct: 606 RGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCN 665

Query: 638 NKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILL---CC- 693
           N  +CHC   W PP C   G+GGS+DSGP P          + + +L++  ++L   CC 
Sbjct: 666 NNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLMYYCCR 725

Query: 694 ----LYRLCKKSKPIKKQQD---------------------VQTPSAKEE----EKIQRR 724
               L +L   + P K +Q                      +QTP  K +     +I R+
Sbjct: 726 QNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTPEILRK 785

Query: 725 PHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPP---VTPSQSQPRVMPSQSQPPV 781
           P + PP+  P  +   S P   P  +H       S  P   +  ++S  R  PS+  PP 
Sbjct: 786 PSQPPPRPPPDYLRGGSPP--APLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIPPA 843

Query: 782 ---MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTP 819
              + SQ   +  P Q   P  P   +  L       P+ P
Sbjct: 844 PNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRP 884


>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
           [Homo sapiens]
          Length = 738

 Score =  355 bits (910), Expect = 1e-97
 Identities = 214/669 (31%), Positives = 336/669 (50%), Gaps = 53/669 (7%)

Query: 32  DVVIPVRITGTTRGMTPPGWLSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQG---A 88
           D+ IPV+   +      P  L+  L    ++ II+++  + L +       Y   G   +
Sbjct: 51  DLWIPVK---SFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVS 107

Query: 89  ILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHL 148
           +  +   +  +CYYHG+V G  +S VSLSTC  G +G++   + +Y ++P+  +T     
Sbjct: 108 LARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFENESYVLEPMKSATN---- 162

Query: 149 VYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI------------DNSTQKQSSYVGWWIH 196
            YK+    K+  ++R     +  T  +  + +               T K + Y      
Sbjct: 163 RYKL-FPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKY------ 215

Query: 197 FRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKN- 255
              VE+V+V DN  + R  ++  K+ + L  I N VD     + ++++L G+E+W + + 
Sbjct: 216 ---VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDK 272

Query: 256 LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCA 314
             V  D   S+H +  W+   + PR  HD + L + +  +G + G+     MCT  +S  
Sbjct: 273 CSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGG 332

Query: 315 IVTFMNKTLGTFSIAVAHHLGHNLGMNHD--EDTCRC----SQPRCIMH--EGNPPITKF 366
           IV   +      ++ +AH LGHN GMNHD  +  C C     +  CIM+   G P    F
Sbjct: 333 IVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVF 392

Query: 367 SNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC 424
           S+CS  D  E ++E+    CL      ++ F  ++CGN  VEEGEECDCG  + C    C
Sbjct: 393 SSCSRKDL-ETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCC 451

Query: 425 CLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDG 484
             + CTL   + CA GLCC+DC+  P+G  CR   N CDLPE+C G S  CP + Y+ DG
Sbjct: 452 NATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDG 511

Query: 485 IPCKE-RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCG-IKNATYI 542
             C++  GYCY   C    +QC  ++G GA  A   C++ +N+ GD  G+CG +  +++ 
Sbjct: 512 HSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFA 571

Query: 543 KCNISDVQCGRIQCENVTEIP-----NMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597
           KC + D +CG+IQC+     P      +S  T +   +   I+C  T  +LG   PD G 
Sbjct: 572 KCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGL 631

Query: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657
           V  GT+C    IC++R C +I++   +     C+ RG+CNN+ +CHC   W PP C   G
Sbjct: 632 VLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFG 691

Query: 658 YGGSVDSGP 666
           +GGS DSGP
Sbjct: 692 FGGSTDSGP 700


>gi|148664238 a disintegrin and metalloprotease domain 32 [Homo
           sapiens]
          Length = 787

 Score =  337 bits (864), Expect = 3e-92
 Identities = 224/755 (29%), Positives = 380/755 (50%), Gaps = 47/755 (6%)

Query: 33  VVIPVRITGTTRGMTPPGW--LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAIL 90
           +VIP +I   T   +   +  +SYI+P   + + +H+K +  L    + ++ Y +QG++ 
Sbjct: 28  IVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLYTVHLKQRYFLADNFM-IYLY-NQGSMN 85

Query: 91  EDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVY 150
                +Q  CYY G +EG P+S+V+LSTC  G +GILQ  + +Y I+PL  +  F+H++Y
Sbjct: 86  TYSSDIQTQCYYQGNIEGYPDSMVTLSTC-SGLRGILQFENVSYGIEPLESAVEFQHVLY 144

Query: 151 KMDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYL 210
           K+ +E+   +     F+   +  +   + I  S + + +    +  +  +E+ +V+D  L
Sbjct: 145 KLKNEDNDIAI----FIDRSLKEQPMDDNIFISEKSEPAVPDLFPLY--LEMHIVVDKTL 198

Query: 211 YIRYERNDSKLLEDLYV-IVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHL 268
           Y  Y  +DS ++ +  + IV + +S+     V ++L  LE+W+++N I  V +  + +  
Sbjct: 199 Y-DYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQK 257

Query: 269 YCKWKSENITPRMQHDTSHLFTTLGLRGLSGIGAFRGMCTPHRSCAIVTFMNK-TLGTFS 327
           + +WK   +  R  HD ++L   +      G      MC    S  +  +  + TL  F+
Sbjct: 258 FLEWKQSYLNLR-PHDIAYLLIYMDYPRYLGAVFPGTMCITRYSAGVALYPKEITLEAFA 316

Query: 328 IAVAHHLGHNLGMNHDEDT-CRCSQPRCIMHEGNPPITK------FSNCSYGDFWEYTVE 380
           + V   L  +LG+++D+   C+CS+  CIM   NP + +      FS+CS   F  +   
Sbjct: 317 VIVTQMLALSLGISYDDPKKCQCSESTCIM---NPEVVQSNGVKTFSSCSLRSFQNFISN 373

Query: 381 -RTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCC-LSNCTLTDGSTCA 438
              KCL      +       CGNG +E  E CDCG    C    CC    C L DG+ C 
Sbjct: 374 VGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCY 433

Query: 439 FGLCCKDCKFLPSGKVCRKEVN-ECDLPEWCNGTSHKCPDDFYVEDGIPCKERGY-CYEK 496
            GLCCKDC+ L SG  CR + + ECD+ E CNG+S +C  D  + +G+ CK   + CY+ 
Sbjct: 434 KGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFICYDG 493

Query: 497 SCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGI-KNATYIKCNISDVQCGRIQ 555
            CHD + +C  +FG G+  A   CY+E+ +  DR G+CG  +N  Y+ C   ++ CGR+ 
Sbjct: 494 DCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLV 553

Query: 556 CENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHC 615
           C   T  P   ++  V +A   D +C + DY L    PD   VK+G++C I  +C++R C
Sbjct: 554 CTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNREC 613

Query: 616 VHITILNSN---CSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSV----DSGPPP 668
           V   I+ ++   CS   C+  G+C++++ CHC+  + PPNC I+  G S+    D G   
Sbjct: 614 VESRIIKASAHVCSQQ-CSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIM 672

Query: 669 KRKK-KKKFCYLCILLLIVLFILLCCLYRLCKK--SKPIKKQQDVQTPSAKEEEKIQRRP 725
           +R   K +  +L   L+ +  +++     L +K   K   K+++  +  +K E   Q   
Sbjct: 673 ERASGKTENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYA 732

Query: 726 HELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQ 760
            +   +       SQ     T S+S  Q   S+S+
Sbjct: 733 SQSSSEGSTQTYASQ-----TRSESSSQADTSKSK 762


>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
           sapiens]
          Length = 735

 Score =  335 bits (860), Expect = 8e-92
 Identities = 204/708 (28%), Positives = 363/708 (51%), Gaps = 55/708 (7%)

Query: 53  SYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILE-DQPFVQNNCYYHGYVEGDPE 111
           SY +   G+ + +++  K  L   +  V++Y+  G +   DQ F QN C+Y GY+EG P+
Sbjct: 46  SYKIVIEGKPYTVNLMQKNFL-PHNFRVYSYSGTGIMKPLDQDF-QNFCHYQGYIEGYPK 103

Query: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQN-E 170
           S+V +STC G  +G+LQ  + +Y I+PL  S  FEH++Y++  ++   S      +++ +
Sbjct: 104 SVVMVSTCTG-LRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRD 162

Query: 171 ITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVN 230
           ++ +++      S + Q  +       + +E+ V+++  LY     + + + + ++ ++ 
Sbjct: 163 LSFKLQ------SVEPQQDFA------KYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIG 210

Query: 231 IVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRMQHDTSHLF 289
           + ++I     + ++L  LE+W ++N I    +  + +H + +WK+  +  R  HD + L 
Sbjct: 211 LTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLR-PHDVAFLL 269

Query: 290 TTLGLRGLSGIGAFRG-MCTPHRSCAIVTFMNK-TLGTFSIAVAHHLGHNLGMNHDE-DT 346
                    G   F+G MC  + +  +V      +L + ++ +A  L  ++G+ +D+ + 
Sbjct: 270 VYREKSNYVG-ATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINK 328

Query: 347 CRCSQPRCIMHEGNPP------ITKFSNCSYGDFWEY-TVERTKCLLETVHTKDIFNVKR 399
           C+CS   CIM   NP       +  FSNCS+ DF  + + ++++CL         F  + 
Sbjct: 329 CQCSGAVCIM---NPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQA 385

Query: 400 -CGNGVVEEGEECDCGPLKHCAK--DPCC-LSNCTLTDGSTCAFGLCCKDCKFLPSGKVC 455
            CGN  +E GEECDCG  + CA   + CC ++ C    GS CA G CC++C F+   ++C
Sbjct: 386 VCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMC 445

Query: 456 RKEVNECDLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGAN 514
           R    ECDLPE+CNG+S  CP++ YV+ G PC   +  C +  C   ++QC   FG    
Sbjct: 446 RPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVE 505

Query: 515 TASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWA 574
                CY  LN+  D  G+CGI ++ Y +C   ++QCG++ C+ V +        T+ +A
Sbjct: 506 FGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYA 565

Query: 575 RFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRG 634
             +  +C + ++           +KDGT CG + +C ++ CV  + L  +C+   CN RG
Sbjct: 566 NISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRG 625

Query: 635 ICNNKHHCHCNYLWDPPNCLIKG---YGGSVDSG--PP---PKRKKKKKFCYLC------ 680
           +CNNK HCHC+  + PP+C ++     GGS+DSG  PP   P R  ++++          
Sbjct: 626 VCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPM 685

Query: 681 ---ILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEKIQRRP 725
                L I  FI+ C L  +  K    +K+   +  S+ E+ + +  P
Sbjct: 686 RWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEP 733


>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
           sapiens]
          Length = 754

 Score =  314 bits (805), Expect = 2e-85
 Identities = 198/669 (29%), Positives = 327/669 (48%), Gaps = 40/669 (5%)

Query: 52  LSYILPFGGQKHIIHI-KVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDP 110
           L Y +    +  ++H+ + ++ L S +   F Y+ +G      P + ++C+Y G +  + 
Sbjct: 59  LLYEIKLNRKTLVLHLLRSREFLGSNYSETF-YSMKGEAFTRHPQIMDHCFYQGSIVHEY 117

Query: 111 ESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNE 170
           +S  S+STC  G +G  +IND  Y I+P+ +S   EHLV+K +          + +   E
Sbjct: 118 DSAASISTC-NGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPY----GANYSCTE 172

Query: 171 ITCRMEFEEIDNSTQKQSSYVGWWIHF-RIVEIVVVIDNYLYIRYERNDSKLLEDLYVIV 229
           +    +    DN +++ S   G  IH  + VE+ +V D+ +Y R     +KL   ++ +V
Sbjct: 173 LNFTRKTVPGDNESEEDSKIKG--IHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMV 230

Query: 230 NIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHL 288
           N V+ I   + + V L G+EIWT+++ I +  ++  ++  +  W+ + +  R   D   L
Sbjct: 231 NFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVL 290

Query: 289 FTTLGLRG-LSGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTC 347
            +   L   + GI    GMC P+ S +I+  +       +  +AH LGHNLGM HDE  C
Sbjct: 291 LSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPC 350

Query: 348 RCSQPRCIMH-EGNPPITKFSNCSYGDFWEYTVE-RTKCLLETVHTKDIFNVKRCGNGVV 405
            C   +C+M  +G+ P  KFS CS   + +Y  + +  C+L      +  + + CGN  +
Sbjct: 351 TCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKL 410

Query: 406 EEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLP 465
           +EGEECDCGP + C    C    C L  G TCA G CC+ C+   +G +CR   +ECD P
Sbjct: 411 DEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFP 470

Query: 466 EWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKEL 524
           E C G S  CP D +  +G PCK   GYC+   C  R +QC  +F   A  + + CYK +
Sbjct: 471 EMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICYK-M 529

Query: 525 NTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHW--ARFNDIMCW 582
           NT G++ G+C  K   ++ C   DV+CG+I C        + +  T H    + N  +  
Sbjct: 530 NTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKC 589

Query: 583 STDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHI--TILNSNCSPAFCNKRGICNNKH 640
            T + L     DIG V  GT+CG   +C +  C+++    +++NC P+ CN+  +  +  
Sbjct: 590 KTIF-LYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNC-PSQCNENPVDGHGL 647

Query: 641 HCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVL----FILLCCLYR 696
            CHC     P  C               +         L ++L++V+     ++L   YR
Sbjct: 648 QCHCEEGQAPVAC--------------EETLHVTNITILVVVLVLVIVGIGVLILLVRYR 693

Query: 697 LCKKSKPIK 705
            C K K ++
Sbjct: 694 KCIKLKQVQ 702


>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 775

 Score =  309 bits (792), Expect = 6e-84
 Identities = 207/755 (27%), Positives = 343/755 (45%), Gaps = 65/755 (8%)

Query: 52  LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPE 111
           L Y +   G+  ++++K  K L +       Y   G  +   P + ++CYY G++  +  
Sbjct: 57  LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKV 116

Query: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLA--FSTTFEHLVYKMDSEEKQFSTMRSGFMQN 169
           S  S+STC  G +G     D  Y I+PL+       EH ++K + +EK + +        
Sbjct: 117 SDASISTC-RGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDS-------- 167

Query: 170 EITCRMEFEEIDNSTQKQSSYVGWWI----------HFRIVEIVVVIDNYLYIRYERNDS 219
             TC M+     +  Q+  +     +          H + +E  +V+DN  + RY  N  
Sbjct: 168 --TCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQD 225

Query: 220 KLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENIT 278
           ++ + ++ + N V+ +   +   V L G+EIWT+K+ I +  +   ++  + KW+   ++
Sbjct: 226 EIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLS 285

Query: 279 PRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHN 337
            R +HD + L T   L G + G+     MC+P+ S  +V   +  L   +  +AH +GHN
Sbjct: 286 RRKRHDIAQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGTMAHEMGHN 344

Query: 338 LGMNHDEDTCRCSQPRCIMHEGNPPI--TKFSNCS---YGDFWEYTVERTKCLLETVHTK 392
            GM HD+ +C+C    C+M +       T FS+CS   Y  F+E  +  + CL       
Sbjct: 345 FGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKL--SNCLFNAPLPT 402

Query: 393 DIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSG 452
           DI +   CGN +VE GE+CDCG  + C    C    C +     CA G CC+ C+F  +G
Sbjct: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAG 462

Query: 453 KVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSCHDRNEQCRRIFGA 511
            VCR   +ECDLPE CNG S  CPDD +  +G PC   +G+C   +C    EQC  ++G 
Sbjct: 463 MVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGP 522

Query: 512 GANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTV 571
           G   A ++CY   N  G + G+C   + T I C  +D  CG++ C+        SD+   
Sbjct: 523 GTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQ------GGSDNLPW 575

Query: 572 HWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHI--TILNSNCSPAF 629
                  + C + D        +IG V +GT+CG + +CI+  CV I     ++NCS + 
Sbjct: 576 KGRIVTFLTCKTFDPE--DTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCS-SK 632

Query: 630 CNKRGICNNKHHCHCNYLWDPPNCLIKG--YGGSVDSGPPPKRKKKKKFCYLCILLLIVL 687
           C    +C+++  C C   W PP+C      +  S+  G               +  + V+
Sbjct: 633 CKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVG--------------VLFPMAVI 678

Query: 688 FILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEKIQRRPH---ELPPQSQPWVMPSQSQPP 744
           F+++  + R     +  KK Q   + +     K +R+P     + PQ    + P     P
Sbjct: 679 FVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVKAVQPQEMSQMKPHVYDLP 738

Query: 745 VTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQP 779
           V  ++         +  P T  +  P   P  S P
Sbjct: 739 VEGNEPPASFHKDTNALPPTVFKDNPVSTPKDSNP 773


>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
           preproprotein [Homo sapiens]
          Length = 813

 Score =  306 bits (784), Expect = 5e-83
 Identities = 234/825 (28%), Positives = 375/825 (45%), Gaps = 78/825 (9%)

Query: 3   MLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVI---PVRITGTTRGMTPPGWLSYILPFG 59
           +LLLL  L   +  +G +Q   P     P  V+   P R       ++ P      L   
Sbjct: 14  LLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAE 73

Query: 60  GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119
           GQ+ ++ ++    L +       Y   G  +   P   ++C+Y G V G P+S V L TC
Sbjct: 74  GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133

Query: 120 FGGFQGILQIN-DFAYEIKPLA------FSTTFEHLVYKMDSEEKQFSTMRSGFMQNEIT 172
             G  G++ ++ + +Y ++P        FST   H +++M+    Q  T +      +  
Sbjct: 134 -SGMSGLITLSRNASYYLRPWPPRGSKDFST---HEIFRME----QLLTWKGTCGHRDPG 185

Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIV 232
            +     +    Q +          + +E+ +V D+ L++   RN +   + L  + N V
Sbjct: 186 NKAGMTSLPGGPQSRGRREARRTR-KYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244

Query: 233 DSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291
           D +L  + ++V L GLE+WT ++   V  D   ++  + +W+   +  +  HD++ L T 
Sbjct: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWR-RGLWAQRPHDSAQLLTG 303

Query: 292 LGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTC--- 347
              +G + G+    GMC    S  + T  ++     +  +AH +GH+LG++HD D C   
Sbjct: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVE 363

Query: 348 -RCSQPRCIMHE--GNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDI-FNVKRCGNG 403
                  C+M    G+P    FS CS      +  +     L       +      CGNG
Sbjct: 364 AAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNG 423

Query: 404 VVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNEC 462
            VE GEECDCGP + C +D CC + NC+L  G+ CA G CC  C   P+G +CR+ + +C
Sbjct: 424 FVEAGEECDCGPGQEC-RDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDC 482

Query: 463 DLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGANTASETCY 521
           DLPE+C GTS  CP D Y+ DG PC +  GYC++ +C    +QC++++G G++ A E C+
Sbjct: 483 DLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACF 542

Query: 522 KELNTLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTE---IPNMSD-HTTVHWARF 576
           + +N+ GD  G+CG      ++ C   D  CG++QC+        P+M    +TVH    
Sbjct: 543 QVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH-LDG 601

Query: 577 NDIMCWST----DYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNK 632
            ++ C          L + G  +G V+ GT+CG   +C  R C              C+ 
Sbjct: 602 QEVTCRGALALPSAQLDLLG--LGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHS 659

Query: 633 RGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILL- 691
            G+CN+ H+CHC   W PP C   G+GGS+DSGP    + +    +L  +LL VL  LL 
Sbjct: 660 HGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPV---QAENHDTFLLAMLLSVLLPLLP 716

Query: 692 -----CCLYRL-----------CKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQS--Q 733
                 C YRL           C++       +D      ++       P EL P +  Q
Sbjct: 717 GAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKD---GPHRDHPLGGVHPMELGPTATGQ 773

Query: 734 PWVMPSQSQPPVTPSQSH-PQVMPSQSQPPVTPSQSQPRVMPSQS 777
           PW        P+ P  SH P   P +  P V+P     +V   +S
Sbjct: 774 PW--------PLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRS 810


>gi|7656861 a disintegrin and metalloprotease domain 18
           preproprotein [Homo sapiens]
          Length = 739

 Score =  306 bits (784), Expect = 5e-83
 Identities = 198/634 (31%), Positives = 308/634 (48%), Gaps = 35/634 (5%)

Query: 54  YILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESL 113
           YI+   GQ + +H+  +  L    L V+TY + G++    P+   +C+Y GY    P S 
Sbjct: 47  YIITIDGQPYTLHLGKQSFLPQNFL-VYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSF 105

Query: 114 VSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMR---SGFMQNE 170
           V+LS C  G +G LQ  + +Y I+P+  S  FEH++Y+M + +   S +    S   Q +
Sbjct: 106 VTLSIC-SGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKD 164

Query: 171 ITCRMEFE-EIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIV 229
              ++    +I N ++    Y+         EI ++++  LY         + + +  ++
Sbjct: 165 QPYKVPLNSQIKNLSKLLPQYL---------EIYIIVEKALYDYMGSEMMAVTQKIVQVI 215

Query: 230 NIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRMQHDTSHL 288
            +V+++     + V+L  LE+W+N+N I    D    +  +  WK + +  R  HD ++L
Sbjct: 216 GLVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILR-PHDIAYL 274

Query: 289 FTTLGLRGLSGIGAFRGMCTPHRSCAIVTFMNKT-LGTFSIAVAHHLGHNLGMNHDEDT- 346
                     G      +C       I  + +   L  FS+ +A  LG N+G+ +D+ T 
Sbjct: 275 LVYRKHPKYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQ 334

Query: 347 CRCSQPRCIM-HEGNPPITK--FSNCSYGDFWEYTVER--TKCLLETVHTKDIF-NVKRC 400
           C C +  CIM HE      +  FSNCS  D+  Y V +  TKCL +  + + +  N   C
Sbjct: 335 CFCLRATCIMNHEAVSASGRKIFSNCSMHDY-RYFVSKFETKCLQKLSNLQPLHQNQPVC 393

Query: 401 GNGVVEEGEECDCGPLKHCAKDPCCLSN-CTLTDGSTCAFGLCCKD-CKFLPSGKVCRKE 458
           GNG++E  EECDCG    C    CC  N C L     C  G CC   C+   +G  CRK 
Sbjct: 394 GNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKS 453

Query: 459 VN-ECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTA 516
           ++ ECD  E+CNGTS  C  D Y  +G  CK    YCY   C   + QC +IFG GA  A
Sbjct: 454 IDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGA 513

Query: 517 SETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARF 576
              C+KE+N+L +R  +CG KN+  + C   DV CG++ C    +  N SD  +  ++  
Sbjct: 514 PFACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYI 573

Query: 577 NDIMCWS--TDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAF-CNKR 633
            D +C S  T   +   G D   V DGT CG +  C+++ C  + ++  NC+    C  +
Sbjct: 574 QDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGK 633

Query: 634 GICNNKHHCHCNYLWDPPNCLIK--GYGGSVDSG 665
           GICNN  +C C     PP+C  +    GGS+D G
Sbjct: 634 GICNNFGNCQCFPGHRPPDCKFQFGSPGGSIDDG 667


>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
          Length = 856

 Score =  291 bits (744), Expect = 2e-78
 Identities = 229/802 (28%), Positives = 359/802 (44%), Gaps = 96/802 (11%)

Query: 32  DVVIPVRITGT-TRGMTP------PGWLSYILPFGGQKHIIHI-KVKKLLFSKHLPVFTY 83
           +VV+P R+ G   R   P      P  +SY+L   G    +H+ K + LL S +   +T 
Sbjct: 30  EVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTA 89

Query: 84  TDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPL-AFS 142
            + G+ + +QP  Q++C+Y G+VEG P+S  SLSTC  G +G  Q+    + I+PL    
Sbjct: 90  AN-GSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTC-AGLRGFFQVGSDLHLIEPLDEGG 147

Query: 143 TTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYV-----GWWI-- 195
               H VY+ +             +Q   TC +  + + +    +++ V     G  +  
Sbjct: 148 EGGRHAVYQAEH-----------LLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPS 196

Query: 196 -HFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNK 254
              R VE+ VV+DN  + +   +++ +   +  +VN VD +   +  +V+L GLEIW ++
Sbjct: 197 RETRYVELYVVVDNAEF-QMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQ 255

Query: 255 NLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRS 312
           +   V  D   ++     W++   T R  HD   L T +   G + G      MC+ H S
Sbjct: 256 DRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCS-HSS 314

Query: 313 CAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDT--CRCSQ----PRCIM--HEGNPPIT 364
            A+    +K     +  +AH +GHNLGM+HDE+   CRC +     RCIM    G+    
Sbjct: 315 GAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPR 374

Query: 365 KFSNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKD 422
            FS+CS   + E  +ER +  CL        +     CGN  VE GE+CDCGP + C   
Sbjct: 375 MFSDCSQA-YLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNR 433

Query: 423 PCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVE 482
            C  + C L +G+ CA G CC++CK  P+G++CR + + CDL E+C+G   +CP+D + E
Sbjct: 434 CCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQE 493

Query: 483 DGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYI 542
           +G PC   GYCY  +C    +QC+  +G G   A E+C+      G +           +
Sbjct: 494 NGTPC-SGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVL 552

Query: 543 KCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGT 602
           +C       GR  C     I ++    T                     G     V +GT
Sbjct: 553 QCKGGQQPLGRAIC-----IVDVCHALTTE------------------DGTAYEPVPEGT 589

Query: 603 ECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSV 662
            CG + +C    C  + +  S+   A C+  G+CN+K  CHC+  W PP+C         
Sbjct: 590 RCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHA 649

Query: 663 DSGPPPKRKKKKKFCYLCILLLIVLFILLC--CLYRLCK---------------KSKPIK 705
            SG  P       F  + ++LL V+ + L    +YR  +               +S P+ 
Sbjct: 650 ASGSLP------VFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLF 703

Query: 706 KQQDVQTPSAKEEEKIQRRPHELPPQS---QPWVMPSQSQPPVTPSQSHPQVMPSQSQP- 761
            Q   + P+        R P EL P +   QP   P+ S     P  + P  + S   P 
Sbjct: 704 HQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPV 763

Query: 762 PVTPSQSQPRVMPSQSQPPVMP 783
           PV   Q+  +V+     PPV P
Sbjct: 764 PVYTRQAPKQVIKPTFAPPVPP 785


>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
           preproprotein [Homo sapiens]
          Length = 787

 Score =  288 bits (737), Expect = 1e-77
 Identities = 230/825 (27%), Positives = 369/825 (44%), Gaps = 104/825 (12%)

Query: 3   MLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVI---PVRITGTTRGMTPPGWLSYILPFG 59
           +LLLL  L   +  +G +Q   P     P  V+   P R       ++ P      L   
Sbjct: 14  LLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAE 73

Query: 60  GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119
           GQ+ ++ ++    L +       Y   G  +   P   ++C+Y G V G P+S V L TC
Sbjct: 74  GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133

Query: 120 FGGFQGILQIN-DFAYEIKPLA------FSTTFEHLVYKMDSEEKQFSTMRSGFMQNEIT 172
             G  G++ ++ + +Y ++P        FST   H +++M+    Q  T +      +  
Sbjct: 134 -SGMSGLITLSRNASYYLRPWPPRGSKDFST---HEIFRME----QLLTWKGTCGHRDPG 185

Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIV 232
            +     +    Q +          + +E+ +V D+ L++   RN +   + L  + N V
Sbjct: 186 NKAGMTSLPGGPQSRGRREARRTR-KYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244

Query: 233 DSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291
           D +L  + ++V L GLE+WT ++   V  D   ++  + +W+   +  +  HD++ L T 
Sbjct: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWR-RGLWAQRPHDSAQLLTG 303

Query: 292 LGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTC--- 347
              +G + G+    GMC    S  + T  ++     +  +AH +GH+LG++HD D C   
Sbjct: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVE 363

Query: 348 -RCSQPRCIMHE--GNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDI-FNVKRCGNG 403
                  C+M    G+P    FS CS      +  +     L       +      CGNG
Sbjct: 364 AAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNG 423

Query: 404 VVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNEC 462
            VE GEECDCGP + C +D CC + NC+L  G+ CA G CC  C   P+G +CR+ + +C
Sbjct: 424 FVEAGEECDCGPGQEC-RDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDC 482

Query: 463 DLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGANTASETCY 521
           DLPE+C GTS  CP D Y+ DG PC +  GYC++ +C    +QC++++G G++ A E C+
Sbjct: 483 DLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACF 542

Query: 522 KELNTLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTE---IPNMSD-HTTVHWARF 576
           + +N+ GD  G+CG      ++ C   D  CG++QC+        P+M    +TVH    
Sbjct: 543 QVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH-LDG 601

Query: 577 NDIMCWST----DYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNK 632
            ++ C          L + G  +G V+ GT+CG                           
Sbjct: 602 QEVTCRGALALPSAQLDLLG--LGLVEPGTQCG--------------------------P 633

Query: 633 RGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILL- 691
           R +CN+ H+CHC   W PP C   G+GGS+DSGP    + +    +L  +LL VL  LL 
Sbjct: 634 RMVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPV---QAENHDTFLLAMLLSVLLPLLP 690

Query: 692 -----CCLYRL-----------CKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQS--Q 733
                 C YRL           C++       +D      ++       P EL P +  Q
Sbjct: 691 GAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKD---GPHRDHPLGGVHPMELGPTATGQ 747

Query: 734 PWVMPSQSQPPVTPSQSH-PQVMPSQSQPPVTPSQSQPRVMPSQS 777
           PW        P+ P  SH P   P +  P V+P     +V   +S
Sbjct: 748 PW--------PLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRS 784


>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
           preproprotein [Homo sapiens]
          Length = 863

 Score =  275 bits (702), Expect = 2e-73
 Identities = 219/816 (26%), Positives = 349/816 (42%), Gaps = 89/816 (10%)

Query: 56  LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115
           L   G  HI+ +   + L      +  Y   G  +  +     NC Y G V G   S VS
Sbjct: 73  LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132

Query: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172
           + TC G              ++ L   T       +    + Q   + S      +   T
Sbjct: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178

Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222
           C + + E  + TQK   +     H R           VE+V+V D+    +Y R+   LL
Sbjct: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236

Query: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281
                +  ++D+    + V+V L GLE WT ++L+ +  +   ++  +  W+  ++ PR+
Sbjct: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296

Query: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340
            HD++ L T     G + G+     +C+P  S  +    + ++   + ++AH LGH+LG+
Sbjct: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356

Query: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391
           +HD   ++C C  P     CIM       P   FSNCS     +  ++    CL E + +
Sbjct: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416

Query: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449
                   CGN  VE GE+CDCG L  C  DPCC S  C L  G+ CA  G CC++C+  
Sbjct: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474

Query: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508
           PSG  CR    +CDLPE+C G S +CP D  + DG PC   +  C    C    +QC+ +
Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534

Query: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567
           +G GA  A+  C +  NT G+  G CG   + +Y+ C   D  CG++QC+     P +  
Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594

Query: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619
              + W   +    ++ C W    HL + G D+ +      GT CG   +CI   C  + 
Sbjct: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650

Query: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679
           +L +    + C+  G+C++  HC+C   W PP+C  +            K         L
Sbjct: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699

Query: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQT-----PSAKEEEKIQRRPH 726
             LL++++ ++L   Y        RLC+   P  + +  Q+     P   +   + R   
Sbjct: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759

Query: 727 ELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQ------PP 780
           +    S P   PS+  PP   S+     +  +  PP  P  + P V   +SQ      PP
Sbjct: 760 QASALSFP-APPSRPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPP 818

Query: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPP 816
             P  + PQ        P   +   P ++PS+  PP
Sbjct: 819 RKPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 854


>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
           preproprotein [Homo sapiens]
          Length = 862

 Score =  273 bits (699), Expect = 4e-73
 Identities = 220/815 (26%), Positives = 350/815 (42%), Gaps = 88/815 (10%)

Query: 56  LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115
           L   G  HI+ +   + L      +  Y   G  +  +     NC Y G V G   S VS
Sbjct: 73  LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132

Query: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172
           + TC G              ++ L   T       +    + Q   + S      +   T
Sbjct: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178

Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222
           C + + E  + TQK   +     H R           VE+V+V D+    +Y R+   LL
Sbjct: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236

Query: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281
                +  ++D+    + V+V L GLE WT ++L+ +  +   ++  +  W+  ++ PR+
Sbjct: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296

Query: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340
            HD++ L T     G + G+     +C+P  S  +    + ++   + ++AH LGH+LG+
Sbjct: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356

Query: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391
           +HD   ++C C  P     CIM       P   FSNCS     +  ++    CL E + +
Sbjct: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416

Query: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449
                   CGN  VE GE+CDCG L  C  DPCC S  C L  G+ CA  G CC++C+  
Sbjct: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474

Query: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508
           PSG  CR    +CDLPE+C G S +CP D  + DG PC   +  C    C    +QC+ +
Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534

Query: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567
           +G GA  A+  C +  NT G+  G CG   + +Y+ C   D  CG++QC+     P +  
Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594

Query: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619
              + W   +    ++ C W    HL + G D+ +      GT CG   +CI   C  + 
Sbjct: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650

Query: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679
           +L +    + C+  G+C++  HC+C   W PP+C  +            K         L
Sbjct: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699

Query: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQTPSAKEEEKIQR----RPHE 727
             LL++++ ++L   Y        RLC+   P  + +  Q+  ++     QR    R  +
Sbjct: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759

Query: 728 LPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQ------PPV 781
               S P   PS+  PP   S+     +  +  PP  P  + P V   +SQ      PP 
Sbjct: 760 ASALSFP-APPSRPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPR 818

Query: 782 MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPP 816
            P  + PQ        P   +   P ++PS+  PP
Sbjct: 819 KPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 853


>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
           preproprotein [Homo sapiens]
          Length = 838

 Score =  271 bits (692), Expect = 2e-72
 Identities = 215/805 (26%), Positives = 343/805 (42%), Gaps = 92/805 (11%)

Query: 56  LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115
           L   G  HI+ +   + L      +  Y   G  +  +     NC Y G V G   S VS
Sbjct: 73  LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132

Query: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172
           + TC G              ++ L   T       +    + Q   + S      +   T
Sbjct: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178

Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222
           C + + E  + TQK   +     H R           VE+V+V D+    +Y R+   LL
Sbjct: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236

Query: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281
                +  ++D+    + V+V L GLE WT ++L+ +  +   ++  +  W+  ++ PR+
Sbjct: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296

Query: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340
            HD++ L T     G + G+     +C+P  S  +    + ++   + ++AH LGH+LG+
Sbjct: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356

Query: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391
           +HD   ++C C  P     CIM       P   FSNCS     +  ++    CL E + +
Sbjct: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416

Query: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449
                   CGN  VE GE+CDCG L  C  DPCC S  C L  G+ CA  G CC++C+  
Sbjct: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474

Query: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508
           PSG  CR    +CDLPE+C G S +CP D  + DG PC   +  C    C    +QC+ +
Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534

Query: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567
           +G GA  A+  C +  NT G+  G CG   + +Y+ C   D  CG++QC+     P +  
Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594

Query: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619
              + W   +    ++ C W    HL + G D+ +      GT CG   +CI   C  + 
Sbjct: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650

Query: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679
           +L +    + C+  G+C++  HC+C   W PP+C  +            K         L
Sbjct: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699

Query: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQ 731
             LL++++ ++L   Y        RLC+   P  + +  Q+  ++     QR    L  +
Sbjct: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQR---ALLAR 756

Query: 732 SQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPPVMPSQSHPQLT 791
                +  +  PP  P  + P V   +SQ P  P             PP  P  + PQ  
Sbjct: 757 GTKAELADRPNPPTRPLPADPVVRSPKSQGPAKP------------PPPRKPLPADPQGR 804

Query: 792 PSQSQPPVTPSQRQPQLMPSQSQPP 816
                 P   +   P ++PS+  PP
Sbjct: 805 CPSGDLPGPGAGIPPLVVPSRPAPP 829


>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
           preproprotein [Homo sapiens]
          Length = 839

 Score =  268 bits (686), Expect = 1e-71
 Identities = 212/792 (26%), Positives = 340/792 (42%), Gaps = 83/792 (10%)

Query: 56  LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115
           L   G  HI+ +   + L      +  Y   G  +  +     NC Y G V G   S VS
Sbjct: 73  LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132

Query: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172
           + TC G              ++ L   T       +    + Q   + S      +   T
Sbjct: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178

Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222
           C + + E  + TQK   +     H R           VE+V+V D+    +Y R+   LL
Sbjct: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236

Query: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281
                +  ++D+    + V+V L GLE WT ++L+ +  +   ++  +  W+  ++ PR+
Sbjct: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296

Query: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340
            HD++ L T     G + G+     +C+P  S  +    + ++   + ++AH LGH+LG+
Sbjct: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356

Query: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391
           +HD   ++C C  P     CIM       P   FSNCS     +  ++    CL E + +
Sbjct: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416

Query: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449
                   CGN  VE GE+CDCG L  C  DPCC S  C L  G+ CA  G CC++C+  
Sbjct: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474

Query: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508
           PSG  CR    +CDLPE+C G S +CP D  + DG PC   +  C    C    +QC+ +
Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534

Query: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567
           +G GA  A+  C +  NT G+  G CG   + +Y+ C   D  CG++QC+     P +  
Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594

Query: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619
              + W   +    ++ C W    HL + G D+ +      GT CG   +CI   C  + 
Sbjct: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650

Query: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679
           +L +    + C+  G+C++  HC+C   W PP+C  +            K         L
Sbjct: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699

Query: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQT-----PSAKEEEKIQRRPH 726
             LL++++ ++L   Y        RLC+   P  + +  Q+     P   +   + R   
Sbjct: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759

Query: 727 ELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPPVMPSQS 786
           +    S P   PS+  PP   S+      P++  PP  P  + P+        P   +  
Sbjct: 760 QASALSFP-APPSRPLPPDPVSKRLQSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAGI 818

Query: 787 HPQLTPSQSQPP 798
            P + PS+  PP
Sbjct: 819 PPLVVPSRPAPP 830


>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
           preproprotein [Homo sapiens]
          Length = 814

 Score =  268 bits (685), Expect = 2e-71
 Identities = 209/769 (27%), Positives = 334/769 (43%), Gaps = 80/769 (10%)

Query: 56  LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115
           L   G  HI+ +   + L      +  Y   G  +  +     NC Y G V G   S VS
Sbjct: 73  LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132

Query: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172
           + TC G              ++ L   T       +    + Q   + S      +   T
Sbjct: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178

Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222
           C + + E  + TQK   +     H R           VE+V+V D+    +Y R+   LL
Sbjct: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236

Query: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281
                +  ++D+    + V+V L GLE WT ++L+ +  +   ++  +  W+  ++ PR+
Sbjct: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296

Query: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340
            HD++ L T     G + G+     +C+P  S  +    + ++   + ++AH LGH+LG+
Sbjct: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356

Query: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391
           +HD   ++C C  P     CIM       P   FSNCS     +  ++    CL E + +
Sbjct: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416

Query: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449
                   CGN  VE GE+CDCG L  C  DPCC S  C L  G+ CA  G CC++C+  
Sbjct: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474

Query: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508
           PSG  CR    +CDLPE+C G S +CP D  + DG PC   +  C    C    +QC+ +
Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534

Query: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567
           +G GA  A+  C +  NT G+  G CG   + +Y+ C   D  CG++QC+     P +  
Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594

Query: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619
              + W   +    ++ C W    HL + G D+ +      GT CG   +CI   C  + 
Sbjct: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650

Query: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679
           +L +    + C+  G+C++  HC+C   W PP+C  +            K         L
Sbjct: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699

Query: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQ 731
             LL++++ ++L   Y        RLC+   P  + +  Q+  ++     QR       +
Sbjct: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759

Query: 732 SQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780
           SQ    P++  PP  P  + PQ        P   +   P V+PS+  PP
Sbjct: 760 SQG---PAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 805


>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
           sapiens]
          Length = 832

 Score =  260 bits (664), Expect = 4e-69
 Identities = 180/606 (29%), Positives = 291/606 (48%), Gaps = 44/606 (7%)

Query: 99  NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAF-----STTFEHLVYK-- 151
           +CYYHG + G  +S V+LSTC  G  G+ + + F Y I+PL       ST   H++ K  
Sbjct: 195 HCYYHGSIRGVKDSKVALSTC-NGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTL 253

Query: 152 --MDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNY 209
               S++ +  TM  G   ++     E + +    +  +   G +   + +E+++V D+ 
Sbjct: 254 AGQYSKQMKNLTMERG---DQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHK 310

Query: 210 LYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVH 267
            Y ++  + +        +VN+VDSI  + +  +V+L  +E WT K+ I +  +  + +H
Sbjct: 311 TYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLH 370

Query: 268 LYCKWKSENITPRMQHDTSHLFTTLGLR-GLSGIGAFRGMCTPHRSCAIVTF--MNKTLG 324
            + K++      +   D  HL + +      S +  F G+C+  R   +  +        
Sbjct: 371 EFSKYRQRI---KQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQ 427

Query: 325 TFSIAVAHHLGHNLGMNHDEDTCRCSQP--RCIMHE-GNPPITKFSNCSYGDFWEYTVER 381
             S ++A +LG     +  +  C C++    CIM E G     KFS CS  ++ ++    
Sbjct: 428 VLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRG 487

Query: 382 TKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGL 441
               L    TK +F    CGNG VE GEECDCG    C     C   C+L++G+ C+ G 
Sbjct: 488 GGACLFNRPTK-LFEPTECGNGYVEAGEECDCGFHVECYG--LCCKKCSLSNGAHCSDGP 544

Query: 442 CCKD--CKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSC 498
           CC +  C F P G  CR  VNECD+ E+C G S +CP + + +DG  C + +G CY   C
Sbjct: 545 CCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGEC 604

Query: 499 HDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCEN 558
             R+ QC+ I+G  A  + + CY++LNT G   G+CG     +I+C+  DV CG + C N
Sbjct: 605 KTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTN 664

Query: 559 VTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHR 613
           +T  P +         T  + +   I C      L     D+G V+DGT CG   +C+ R
Sbjct: 665 LTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLD-DDTDVGYVEDGTPCGPSMMCLDR 723

Query: 614 HCVHITILNSNCSP-----AFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPP 668
            C+ I  LN +  P       C+  G+C+N+  C C++ W   +C I+     V +  PP
Sbjct: 724 KCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIR---DPVRNLHPP 780

Query: 669 KRKKKK 674
           K +  K
Sbjct: 781 KDEGPK 786


>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
           [Homo sapiens]
          Length = 906

 Score =  258 bits (660), Expect = 1e-68
 Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)

Query: 99  NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154
           +CYY G++ G+P+S V+LSTC G   G+    +  Y I+P    TT E    H VYK   
Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192

Query: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202
            E     + S F Q  IT             + +      + ++++ Y+         E+
Sbjct: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243

Query: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260
           ++V D+ ++ ++  +          +VN+ D I  D +  +++L  +E W   N   + +
Sbjct: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303

Query: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319
           +   ++  + K++ + I  + + D  HLF+        SG     G+C+  +   +  F 
Sbjct: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361

Query: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371
              L   ++ +A  L HN+G+  D+       C+C      CIM + G     KF+ C+ 
Sbjct: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419

Query: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430
            ++ ++        L    +K + +   CGNG +E GEECDCG    C  +   C   CT
Sbjct: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478

Query: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489
           LT  S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C  + +  DG  C   
Sbjct: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538

Query: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549
           +G C+   C  R+ QC+ I+G     + + CY++LN  G   G+CG    T+I+CN  DV
Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598

Query: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604
            CG + C N+  IP + +      +T+   +   + C      L  +  D+G V+DGT C
Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657

Query: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653
           G   +C+   C+ +   N     S+     C+  G+C+N+  C CN  W   +C
Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711


>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
           [Homo sapiens]
          Length = 899

 Score =  258 bits (660), Expect = 1e-68
 Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)

Query: 99  NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154
           +CYY G++ G+P+S V+LSTC G   G+    +  Y I+P    TT E    H VYK   
Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192

Query: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202
            E     + S F Q  IT             + +      + ++++ Y+         E+
Sbjct: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243

Query: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260
           ++V D+ ++ ++  +          +VN+ D I  D +  +++L  +E W   N   + +
Sbjct: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303

Query: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319
           +   ++  + K++ + I  + + D  HLF+        SG     G+C+  +   +  F 
Sbjct: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361

Query: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371
              L   ++ +A  L HN+G+  D+       C+C      CIM + G     KF+ C+ 
Sbjct: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419

Query: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430
            ++ ++        L    +K + +   CGNG +E GEECDCG    C  +   C   CT
Sbjct: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478

Query: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489
           LT  S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C  + +  DG  C   
Sbjct: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538

Query: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549
           +G C+   C  R+ QC+ I+G     + + CY++LN  G   G+CG    T+I+CN  DV
Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598

Query: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604
            CG + C N+  IP + +      +T+   +   + C      L  +  D+G V+DGT C
Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657

Query: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653
           G   +C+   C+ +   N     S+     C+  G+C+N+  C CN  W   +C
Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711


>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
           [Homo sapiens]
          Length = 823

 Score =  258 bits (660), Expect = 1e-68
 Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)

Query: 99  NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154
           +CYY G++ G+P+S V+LSTC G   G+    +  Y I+P    TT E    H VYK   
Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192

Query: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202
            E     + S F Q  IT             + +      + ++++ Y+         E+
Sbjct: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243

Query: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260
           ++V D+ ++ ++  +          +VN+ D I  D +  +++L  +E W   N   + +
Sbjct: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303

Query: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319
           +   ++  + K++ + I  + + D  HLF+        SG     G+C+  +   +  F 
Sbjct: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361

Query: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371
              L   ++ +A  L HN+G+  D+       C+C      CIM + G     KF+ C+ 
Sbjct: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419

Query: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430
            ++ ++        L    +K + +   CGNG +E GEECDCG    C  +   C   CT
Sbjct: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478

Query: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489
           LT  S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C  + +  DG  C   
Sbjct: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538

Query: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549
           +G C+   C  R+ QC+ I+G     + + CY++LN  G   G+CG    T+I+CN  DV
Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598

Query: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604
            CG + C N+  IP + +      +T+   +   + C      L  +  D+G V+DGT C
Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657

Query: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653
           G   +C+   C+ +   N     S+     C+  G+C+N+  C CN  W   +C
Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711


>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
           [Homo sapiens]
          Length = 870

 Score =  258 bits (660), Expect = 1e-68
 Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)

Query: 99  NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154
           +CYY G++ G+P+S V+LSTC G   G+    +  Y I+P    TT E    H VYK   
Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192

Query: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202
            E     + S F Q  IT             + +      + ++++ Y+         E+
Sbjct: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243

Query: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260
           ++V D+ ++ ++  +          +VN+ D I  D +  +++L  +E W   N   + +
Sbjct: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303

Query: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319
           +   ++  + K++ + I  + + D  HLF+        SG     G+C+  +   +  F 
Sbjct: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361

Query: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371
              L   ++ +A  L HN+G+  D+       C+C      CIM + G     KF+ C+ 
Sbjct: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419

Query: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430
            ++ ++        L    +K + +   CGNG +E GEECDCG    C  +   C   CT
Sbjct: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478

Query: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489
           LT  S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C  + +  DG  C   
Sbjct: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538

Query: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549
           +G C+   C  R+ QC+ I+G     + + CY++LN  G   G+CG    T+I+CN  DV
Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598

Query: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604
            CG + C N+  IP + +      +T+   +   + C      L  +  D+G V+DGT C
Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657

Query: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653
           G   +C+   C+ +   N     S+     C+  G+C+N+  C CN  W   +C
Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711


>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
           [Homo sapiens]
          Length = 859

 Score =  258 bits (660), Expect = 1e-68
 Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)

Query: 99  NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154
           +CYY G++ G+P+S V+LSTC G   G+    +  Y I+P    TT E    H VYK   
Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192

Query: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202
            E     + S F Q  IT             + +      + ++++ Y+         E+
Sbjct: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243

Query: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260
           ++V D+ ++ ++  +          +VN+ D I  D +  +++L  +E W   N   + +
Sbjct: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303

Query: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319
           +   ++  + K++ + I  + + D  HLF+        SG     G+C+  +   +  F 
Sbjct: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361

Query: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371
              L   ++ +A  L HN+G+  D+       C+C      CIM + G     KF+ C+ 
Sbjct: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419

Query: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430
            ++ ++        L    +K + +   CGNG +E GEECDCG    C  +   C   CT
Sbjct: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478

Query: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489
           LT  S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C  + +  DG  C   
Sbjct: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538

Query: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549
           +G C+   C  R+ QC+ I+G     + + CY++LN  G   G+CG    T+I+CN  DV
Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598

Query: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604
            CG + C N+  IP + +      +T+   +   + C      L  +  D+G V+DGT C
Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657

Query: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653
           G   +C+   C+ +   N     S+     C+  G+C+N+  C CN  W   +C
Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.456 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,400,739
Number of Sequences: 37866
Number of extensions: 2110461
Number of successful extensions: 19947
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 233
Number of HSP's successfully gapped in prelim test: 818
Number of HSP's that attempted gapping in prelim test: 10269
Number of HSP's gapped (non-prelim): 5796
length of query: 820
length of database: 18,247,518
effective HSP length: 111
effective length of query: 709
effective length of database: 14,044,392
effective search space: 9957473928
effective search space used: 9957473928
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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