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Search of human proteins with 195232763
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|195232763 ADAM metallopeptidase domain 29 preproprotein
[Homo sapiens]
(820 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo... 1767 0.0
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo... 1767 0.0
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo... 1767 0.0
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ... 1767 0.0
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ... 810 0.0
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ... 782 0.0
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H... 515 e-146
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ... 491 e-138
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot... 363 e-100
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ... 361 2e-99
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot... 355 1e-97
gi|148664238 a disintegrin and metalloprotease domain 32 [Homo s... 337 3e-92
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi... 335 8e-92
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ... 314 2e-85
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot... 309 6e-84
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro... 306 5e-83
gi|7656861 a disintegrin and metalloprotease domain 18 prepropro... 306 5e-83
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens] 291 2e-78
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop... 288 1e-77
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor... 275 2e-73
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor... 273 4e-73
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor... 271 2e-72
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor... 268 1e-71
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor... 268 2e-71
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s... 260 4e-69
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot... 258 1e-68
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot... 258 1e-68
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot... 258 1e-68
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot... 258 1e-68
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote... 258 1e-68
>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 1767 bits (4576), Expect = 0.0
Identities = 820/820 (100%), Positives = 820/820 (100%)
Query: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG
Sbjct: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
Query: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF
Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG
Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
Query: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300
VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI
Sbjct: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300
Query: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360
GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN
Sbjct: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360
Query: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420
PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA
Sbjct: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420
Query: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480
KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY
Sbjct: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480
Query: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540
VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT
Sbjct: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540
Query: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600
YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD
Sbjct: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600
Query: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660
GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG
Sbjct: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660
Query: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720
SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK
Sbjct: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720
Query: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780
IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP
Sbjct: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780
Query: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820
VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS
Sbjct: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820
>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 1767 bits (4576), Expect = 0.0
Identities = 820/820 (100%), Positives = 820/820 (100%)
Query: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG
Sbjct: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
Query: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF
Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG
Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
Query: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300
VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI
Sbjct: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300
Query: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360
GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN
Sbjct: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360
Query: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420
PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA
Sbjct: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420
Query: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480
KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY
Sbjct: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480
Query: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540
VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT
Sbjct: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540
Query: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600
YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD
Sbjct: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600
Query: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660
GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG
Sbjct: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660
Query: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720
SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK
Sbjct: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720
Query: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780
IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP
Sbjct: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780
Query: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820
VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS
Sbjct: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820
>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 1767 bits (4576), Expect = 0.0
Identities = 820/820 (100%), Positives = 820/820 (100%)
Query: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG
Sbjct: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
Query: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF
Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG
Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
Query: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300
VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI
Sbjct: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300
Query: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360
GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN
Sbjct: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360
Query: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420
PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA
Sbjct: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420
Query: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480
KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY
Sbjct: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480
Query: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540
VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT
Sbjct: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540
Query: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600
YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD
Sbjct: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600
Query: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660
GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG
Sbjct: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660
Query: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720
SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK
Sbjct: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720
Query: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780
IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP
Sbjct: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780
Query: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820
VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS
Sbjct: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820
>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 1767 bits (4576), Expect = 0.0
Identities = 820/820 (100%), Positives = 820/820 (100%)
Query: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG
Sbjct: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
Query: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF
Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG
Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
Query: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300
VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI
Sbjct: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300
Query: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360
GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN
Sbjct: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360
Query: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420
PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA
Sbjct: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420
Query: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480
KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY
Sbjct: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480
Query: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540
VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT
Sbjct: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540
Query: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600
YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD
Sbjct: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600
Query: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660
GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG
Sbjct: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660
Query: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720
SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK
Sbjct: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720
Query: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780
IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP
Sbjct: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780
Query: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820
VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS
Sbjct: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820
>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
sapiens]
Length = 776
Score = 810 bits (2091), Expect = 0.0
Identities = 378/718 (52%), Positives = 488/718 (67%), Gaps = 11/718 (1%)
Query: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
+++ LLL G+FLS SGH Q QY + P+VVIP+++ RG PGWLSY L FGG
Sbjct: 60 IRVTLLLLWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGG 119
Query: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
Q++I+H++V KLLF+ HLPVFTYT+Q A+L+DQPF+Q++CYYHGYVEG PESLV+LSTC
Sbjct: 120 QRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCS 179
Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
GGF G+LQIND YEIKP++ S TFEHLVYK+DS++ QF MR G + +I +ME +
Sbjct: 180 GGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLS 239
Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
N T KQSS+VGWW H R VE+VVV+DN Y+ + N + + +++ +VNIVDS +
Sbjct: 240 YNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLE 299
Query: 241 VKVLLFGLEIWTNKN-LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFT--TLGLRGL 297
V V+L G++IWT N L D+ + + WK+ N+ R+QHD +HLF T G++
Sbjct: 300 VDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMK-- 357
Query: 298 SGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMH 357
G+ +G+C + + F + L F+I + H LGHNLGM HD C C CIMH
Sbjct: 358 LGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVCELQWCIMH 417
Query: 358 EGNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLK 417
TKFSNCSY +W+ T+ C+ + +IF +K CGN VVEEGEECDCG ++
Sbjct: 418 AYRKVTTKFSNCSYAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIR 477
Query: 418 HCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPD 477
CAKDPCCL NCTL G+ CAFG+CCKDCKFLPSG +CR++V ECDLPEWCNGTSH+CPD
Sbjct: 478 QCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPD 537
Query: 478 DFYVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIK 537
D YV+DGI C +CYEK+C++ + QC+ IFG A +AS++CY+E+NT G+R GHCGI
Sbjct: 538 DVYVQDGISCNVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIV 597
Query: 538 NATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597
TY+KC D+ CGR+QCENV IPN+ +H+TV ND CW TDYHLGM PDIGE
Sbjct: 598 GTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIPDIGE 657
Query: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657
VKDGT CG + ICI + C + L+ C P CN RGICNNK HCHCN+ W PP C KG
Sbjct: 658 VKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAPPYCKDKG 717
Query: 658 YGGSVDSGPPPKRKKK-----KKFCYLCILLLIVLF-ILLCCLYRLCKKSKPIKKQQD 709
YGGS DSGPPPK + K YL +L L+ L LL CL+ L KK K+ ++
Sbjct: 718 YGGSADSGPPPKNNMEGLNVMGKLRYLSLLCLLPLVAFLLFCLHVLFKKRTKSKEDEE 775
>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
sapiens]
Length = 722
Score = 782 bits (2019), Expect = 0.0
Identities = 357/711 (50%), Positives = 481/711 (67%), Gaps = 9/711 (1%)
Query: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
+++ LLL LGVFLS SG+ Q Q+ + P+VVIP+++ R PGWLSY L FGG
Sbjct: 10 IRVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYSLRFGG 69
Query: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
QKH++H++VKKLL S+HLPVFTYTD+ A+LEDQ F+ ++CYYHGYVEG PESLV S CF
Sbjct: 70 QKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPESLVVFSACF 129
Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCR-MEFEE 179
GGF+G+L+I+ YEI+P+ S TFEHLVYK++S E QF MR G + E+ + +EFEE
Sbjct: 130 GGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQLEFEE 189
Query: 180 IDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVI 239
+NS + S WW H +E+VVV+++ +I + N SK+ ED++++VNIVDS+ +
Sbjct: 190 AENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQL 249
Query: 240 GVKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSG 299
G ++L G+EIW N+ + + + ++ + +WK +++ ++QHD +H+F L + G
Sbjct: 250 GTYIILIGIEIWNQGNVFPMTSIEQVLNDFSQWKQISLS-QLQHDAAHMFIKNSLISILG 308
Query: 300 IGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEG 359
+ G+C P C + F T F+ VAH LGH LGM HDE+ C C + CIM+
Sbjct: 309 LAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFCGERGCIMNTF 368
Query: 360 NPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHC 419
P KF+NCSY DF + T+ + CL +IF +KRCGNGVVE E+CDCG ++ C
Sbjct: 369 RVPAEKFTNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQC 428
Query: 420 AKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDF 479
+D CCL NCTL G+ CAFGLCCKDCKF+PSG++CR+EVNECDLPEWCNGTSH+CP+D
Sbjct: 429 EQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDR 488
Query: 480 YVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNA 539
YV+DGIPC + YCY+K C++ ++ CR IFG A +AS+ CYKE+N+ G+R GHCGI
Sbjct: 489 YVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGT 548
Query: 540 TYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVK 599
TY+KC+ISDV CGR+QCENV +IP + DH T+ N + CW DYHL M DIGEVK
Sbjct: 549 TYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMNISDIGEVK 608
Query: 600 DGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYG 659
DGT CG ICIH+ CV +++L+ C P CN +GICNNKHHCHC Y W PP C +GYG
Sbjct: 609 DGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYG 668
Query: 660 GSVDSGPPPKRKKKKKFCYLCIL----LLIVLFILLCCLY-RLCKKSKPIK 705
GS+DSG P K+ F L ++ +L LF + +Y R C K K
Sbjct: 669 GSIDSG--PASAKRGVFLPLIVIPSLSVLTFLFTVGLLMYLRQCSGPKETK 717
>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
sapiens]
Length = 819
Score = 515 bits (1326), Expect = e-146
Identities = 281/803 (34%), Positives = 430/803 (53%), Gaps = 30/803 (3%)
Query: 1 MKMLLLLHCLGVFLSCS--GHIQDEHPQYHSPPDVVIPVRITGTTRGMTPP--GWLSYIL 56
++ LLLL +G L + G Q H + +++ P R+T R P +SY++
Sbjct: 14 VRWLLLLGLVGPVLGAARPGFQQTSHLSSY---EIITPWRLTRERREAPRPYSKQVSYVI 70
Query: 57 PFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSL 116
G++HIIH++ K L + V+TY +G ++ D P +QN+C+Y GYVEG S ++L
Sbjct: 71 QAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIAL 130
Query: 117 STCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---TC 173
S CFG +G+L + + +Y I+PL S+ FEH++Y+MD K+ ++ G +I T
Sbjct: 131 SDCFG-LRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKE--PLKCGVSNKDIEKETA 187
Query: 174 RMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVD 233
+ E EE + TQ R VE+ +V+D Y RN + + E++ ++ N +D
Sbjct: 188 KDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLD 247
Query: 234 SILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTL 292
S+ ++ ++++L GLEIWTN NLI +V + + +W+ + + R +HD++ L
Sbjct: 248 SMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKK 307
Query: 293 GLRGLSGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDT-CRCSQ 351
G G +G+ +C+ + I F T+ TF+ VAH LGHNLGMNHD+ C C
Sbjct: 308 GFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGA 367
Query: 352 PRCIMHEGNPPITKFSNCSYGDFWEYTVERT-KCLLETVHTKDIFNVKRCGNGVVEEGEE 410
CIM+ G FS+CS DF + T+ + CLL + ++ CGN +V+ GEE
Sbjct: 368 KSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEE 427
Query: 411 CDCGPLKHCAKDPCCL-SNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCN 469
CDCG K C DPCC S C L + CA+G CCKDC+FLP G +CR + +ECD+PE+CN
Sbjct: 428 CDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCN 487
Query: 470 GTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLG 528
G+S C D ++++G PC+ + YCY C + QC+ IFG+ A A + C+ E+N+ G
Sbjct: 488 GSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKG 547
Query: 529 DRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHL 588
DR G+CG Y KC + CG++QCENV EIP + CW D+ L
Sbjct: 548 DRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQL 607
Query: 589 GMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCS-PAFCNKRGICNNKHHCHCNYL 647
G PD G V +GT+CG IC + CV ++LN +C C+ G+CN+ +CHC
Sbjct: 608 GSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENG 667
Query: 648 WDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCK-----KSK 702
W PPNC KGYGGSVDSGP L + +++ +++C ++ K +S
Sbjct: 668 WAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSY 727
Query: 703 PIKKQQDVQTPSAKEEEKIQRRPHELP----PQSQPWVMPSQSQPPVTPSQS--HPQVMP 756
KK+ K + R+P +P P + P +P + P+ + PQ P
Sbjct: 728 FRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAAKQPQQFP 787
Query: 757 SQSQPPVTPSQSQPRVMPSQSQP 779
S+ PP SQ ++P++ P
Sbjct: 788 SRPPPPQPKVSSQGNLIPARPAP 810
>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
sapiens]
Length = 790
Score = 491 bits (1263), Expect = e-138
Identities = 267/793 (33%), Positives = 432/793 (54%), Gaps = 33/793 (4%)
Query: 4 LLLLHCLGVFLSCSGHIQDEHPQYHSPP-DVVIPVRIT--GTTRGMTPPGWLSYILPFGG 60
LLLL + L G HP+ +V IP +++ G +G+ P +SY+L G
Sbjct: 13 LLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSP--VSYLLQLKG 70
Query: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
+KH++H+ K+LL +HL VF++T+ G +LED P++ +C Y G V+ +S ++STC
Sbjct: 71 KKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCM 130
Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
GG +G+ I+ Y+I+PL S +FEH+VY + E QF G +EI +M E
Sbjct: 131 GGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKE--QFGNQVCGLSDDEIEWQMAPYE- 187
Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
+ + + G + H + +E++++ D Y N S+++ D ++ I+D+ +
Sbjct: 188 --NKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVR 245
Query: 241 VKVLLFGLEIWTNKNLIVVD--DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS 298
+++ L LE+WT+ N I V ++ + + + +K + R+ D +HL+
Sbjct: 246 MRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDAL 305
Query: 299 GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRC-SQPRCIMH 357
+F +C+ + ++ T ++ + + AH LGH +GM+HDE C+C + CIM
Sbjct: 306 A-WSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLNCIMG 364
Query: 358 EGNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLK 417
G T FSNCSY F+++ CL + +KRCGN +VE+ EECDCG +
Sbjct: 365 SGR---TGFSNCSYISFFKHISSGATCLNNIPGLGYV--LKRCGNKIVEDNEECDCGSTE 419
Query: 418 HCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPD 477
C KD CC SNC L G+ C+ GLCC DC+F PSG VCR+E NECDL E+C+G S CP+
Sbjct: 420 ECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPN 479
Query: 478 DFYVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHC--- 534
D Y +DG PCK G C+ K C R QC+ IFG A A CY +N +GD+ G+C
Sbjct: 480 DVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEIT 539
Query: 535 GIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTV--HWARFNDIMCWSTDYHLGMKG 592
GI+N + KC ++ CGR+QC NV IP++ +HTT+ + ++MCW T YHL MK
Sbjct: 540 GIRN--FKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKP 597
Query: 593 ---PDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWD 649
PD+G + DGT CG +C ++CV+ ++L +C P CN RG+CNN+ +CHC Y W
Sbjct: 598 MGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWA 657
Query: 650 PPNCLIKGYGGSVDSGPPP--KRKKKKKFCYLCILLLIVLFILLCCLYRLCKK--SKPIK 705
PP C GYGGS+DSGPP + + I++ ++ ++L ++ ++ +K
Sbjct: 658 PPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLK 717
Query: 706 KQQDVQTPSAKEEEKIQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTP 765
+Q+ S + E+ + + + +S+ +S+ +S + +S+ +
Sbjct: 718 PKQEKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIES 777
Query: 766 SQSQPRVMPSQSQ 778
+ + + + Q +
Sbjct: 778 KRPKAKSVKKQKK 790
>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
[Homo sapiens]
Length = 909
Score = 363 bits (931), Expect = e-100
Identities = 246/850 (28%), Positives = 396/850 (46%), Gaps = 88/850 (10%)
Query: 32 DVVIPVRITGTTRGMTPPGWLSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQG---A 88
D+ IPV+ + P L+ L ++ II+++ + L + Y G +
Sbjct: 51 DLWIPVK---SFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVS 107
Query: 89 ILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHL 148
+ + + +CYYHG+V G +S VSLSTC G +G++ + +Y ++P+ +T
Sbjct: 108 LARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFENESYVLEPMKSATN---- 162
Query: 149 VYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI------------DNSTQKQSSYVGWWIH 196
YK+ K+ ++R + T + + + T K + Y
Sbjct: 163 RYKL-FPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKY------ 215
Query: 197 FRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKN- 255
VE+V+V DN + R ++ K+ + L I N VD + ++++L G+E+W + +
Sbjct: 216 ---VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDK 272
Query: 256 LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCA 314
V D S+H + W+ + PR HD + L + + +G + G+ MCT +S
Sbjct: 273 CSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGG 332
Query: 315 IVTFMNKTLGTFSIAVAHHLGHNLGMNHD--EDTCRC----SQPRCIMH--EGNPPITKF 366
IV + ++ +AH LGHN GMNHD + C C + CIM+ G P F
Sbjct: 333 IVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVF 392
Query: 367 SNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC 424
S+CS D E ++E+ CL ++ F ++CGN VEEGEECDCG + C C
Sbjct: 393 SSCSRKDL-ETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCC 451
Query: 425 CLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDG 484
+ CTL + CA GLCC+DC+ P+G CR N CDLPE+C G S CP + Y+ DG
Sbjct: 452 NATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDG 511
Query: 485 IPCKE-RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCG-IKNATYI 542
C++ GYCY C +QC ++G GA A C++ +N+ GD G+CG + +++
Sbjct: 512 HSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFA 571
Query: 543 KCNISDVQCGRIQCENVTEIP-----NMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597
KC + D +CG+IQC+ P +S T + + I+C T +LG PD G
Sbjct: 572 KCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGL 631
Query: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657
V GT+C IC++R C +I++ + C+ RG+CNN+ +CHC W PP C G
Sbjct: 632 VLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFG 691
Query: 658 YGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLY---------------------- 695
+GGS DSGP + + L I +L+ + LL +
Sbjct: 692 FGGSTDSGPIRQADNQG----LTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIE 747
Query: 696 --RLCKKSKPIKKQQDVQTPSAKEEEKIQRRPHE-LPPQSQP-WVMPSQSQPPVTPSQSH 751
R + S+P + Q Q + + R+P + PP+ P ++ Q+ P
Sbjct: 748 KLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGL 807
Query: 752 PQVMPSQSQPPVTPSQSQPR-----VMPSQSQPPVMPSQSHPQLTPSQSQPPVTPSQRQP 806
P +Q + P PR P ++P + +Q + P Q P P R
Sbjct: 808 NVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTT 867
Query: 807 QLMPSQSQPP 816
+L + ++ P
Sbjct: 868 RLTHALARTP 877
>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
sapiens]
Length = 918
Score = 361 bits (926), Expect = 2e-99
Identities = 244/821 (29%), Positives = 386/821 (47%), Gaps = 70/821 (8%)
Query: 60 GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119
G++ I+ ++ + LF+ YT G ++++C+YHG V S V+LSTC
Sbjct: 73 GRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTC 132
Query: 120 FGGFQGILQIN-DFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFE 178
G +G++ ++ + +Y I+PL S +HL+Y+ SE + GF ++ T R
Sbjct: 133 -RGIRGLITVSSNLSYVIEPLPDSKG-QHLIYR--SEHLKPPPGNCGFEHSKPTTRDWAL 188
Query: 179 EIDNSTQKQSSYVGW--WIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL 236
+ T+K+ + + VE+ +V D + + R+ L I N VD
Sbjct: 189 QFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFY 248
Query: 237 DVIGVKVLLFGLEIWTNKNLIVV-DDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLR 295
+ +++ L GLE+WT+ N+ V ++ ++ + W+ + + + HD + L T +
Sbjct: 249 RSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKY-HDNAQLITGMSFH 307
Query: 296 GLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPR- 353
G + G+ MC+ ++S + ++ + +AH +GHN GM HD C CS
Sbjct: 308 GTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADC-CSASAA 366
Query: 354 ---CIMHE--GNPPITKFSNCSYGDFWEYTVERT-KCLLETVHTKDIFNVKRCGNGVVEE 407
CIM G+P F+ C+ + Y CL T+ ++ +RCGNG +E+
Sbjct: 367 DGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLED 426
Query: 408 GEECDCGPLKHCAKDPCC-LSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPE 466
GEECDCG + C +PCC SNCTL G+ CA G CC CK L G +CR++ +CDLPE
Sbjct: 427 GEECDCGEEEEC-NNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDLPE 485
Query: 467 WCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELN 525
+C G S CP +FY DG PC+ + YCY C EQC++++G GA A + C++++N
Sbjct: 486 FCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVN 545
Query: 526 TLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWA---RFNDIMC 581
GD G+CG N + KCN+ D +CG+IQC++ P S+ + I C
Sbjct: 546 VAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQC 605
Query: 582 WSTDYHLGMKGP----DIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICN 637
T + G + D G V GT+CG +HIC C + + + CN G+CN
Sbjct: 606 RGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCN 665
Query: 638 NKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILL---CC- 693
N +CHC W PP C G+GGS+DSGP P + + +L++ ++L CC
Sbjct: 666 NNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLMYYCCR 725
Query: 694 ----LYRLCKKSKPIKKQQD---------------------VQTPSAKEE----EKIQRR 724
L +L + P K +Q +QTP K + +I R+
Sbjct: 726 QNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTPEILRK 785
Query: 725 PHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPP---VTPSQSQPRVMPSQSQPPV 781
P + PP+ P + S P P +H S P + ++S R PS+ PP
Sbjct: 786 PSQPPPRPPPDYLRGGSPP--APLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIPPA 843
Query: 782 ---MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTP 819
+ SQ + P Q P P + L P+ P
Sbjct: 844 PNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRP 884
>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
[Homo sapiens]
Length = 738
Score = 355 bits (910), Expect = 1e-97
Identities = 214/669 (31%), Positives = 336/669 (50%), Gaps = 53/669 (7%)
Query: 32 DVVIPVRITGTTRGMTPPGWLSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQG---A 88
D+ IPV+ + P L+ L ++ II+++ + L + Y G +
Sbjct: 51 DLWIPVK---SFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVS 107
Query: 89 ILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHL 148
+ + + +CYYHG+V G +S VSLSTC G +G++ + +Y ++P+ +T
Sbjct: 108 LARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFENESYVLEPMKSATN---- 162
Query: 149 VYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI------------DNSTQKQSSYVGWWIH 196
YK+ K+ ++R + T + + + T K + Y
Sbjct: 163 RYKL-FPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKY------ 215
Query: 197 FRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKN- 255
VE+V+V DN + R ++ K+ + L I N VD + ++++L G+E+W + +
Sbjct: 216 ---VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDK 272
Query: 256 LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCA 314
V D S+H + W+ + PR HD + L + + +G + G+ MCT +S
Sbjct: 273 CSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGG 332
Query: 315 IVTFMNKTLGTFSIAVAHHLGHNLGMNHD--EDTCRC----SQPRCIMH--EGNPPITKF 366
IV + ++ +AH LGHN GMNHD + C C + CIM+ G P F
Sbjct: 333 IVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVF 392
Query: 367 SNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC 424
S+CS D E ++E+ CL ++ F ++CGN VEEGEECDCG + C C
Sbjct: 393 SSCSRKDL-ETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCC 451
Query: 425 CLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDG 484
+ CTL + CA GLCC+DC+ P+G CR N CDLPE+C G S CP + Y+ DG
Sbjct: 452 NATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDG 511
Query: 485 IPCKE-RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCG-IKNATYI 542
C++ GYCY C +QC ++G GA A C++ +N+ GD G+CG + +++
Sbjct: 512 HSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFA 571
Query: 543 KCNISDVQCGRIQCENVTEIP-----NMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597
KC + D +CG+IQC+ P +S T + + I+C T +LG PD G
Sbjct: 572 KCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGL 631
Query: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657
V GT+C IC++R C +I++ + C+ RG+CNN+ +CHC W PP C G
Sbjct: 632 VLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFG 691
Query: 658 YGGSVDSGP 666
+GGS DSGP
Sbjct: 692 FGGSTDSGP 700
>gi|148664238 a disintegrin and metalloprotease domain 32 [Homo
sapiens]
Length = 787
Score = 337 bits (864), Expect = 3e-92
Identities = 224/755 (29%), Positives = 380/755 (50%), Gaps = 47/755 (6%)
Query: 33 VVIPVRITGTTRGMTPPGW--LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAIL 90
+VIP +I T + + +SYI+P + + +H+K + L + ++ Y +QG++
Sbjct: 28 IVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLYTVHLKQRYFLADNFM-IYLY-NQGSMN 85
Query: 91 EDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVY 150
+Q CYY G +EG P+S+V+LSTC G +GILQ + +Y I+PL + F+H++Y
Sbjct: 86 TYSSDIQTQCYYQGNIEGYPDSMVTLSTC-SGLRGILQFENVSYGIEPLESAVEFQHVLY 144
Query: 151 KMDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYL 210
K+ +E+ + F+ + + + I S + + + + + +E+ +V+D L
Sbjct: 145 KLKNEDNDIAI----FIDRSLKEQPMDDNIFISEKSEPAVPDLFPLY--LEMHIVVDKTL 198
Query: 211 YIRYERNDSKLLEDLYV-IVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHL 268
Y Y +DS ++ + + IV + +S+ V ++L LE+W+++N I V + + +
Sbjct: 199 Y-DYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQK 257
Query: 269 YCKWKSENITPRMQHDTSHLFTTLGLRGLSGIGAFRGMCTPHRSCAIVTFMNK-TLGTFS 327
+ +WK + R HD ++L + G MC S + + + TL F+
Sbjct: 258 FLEWKQSYLNLR-PHDIAYLLIYMDYPRYLGAVFPGTMCITRYSAGVALYPKEITLEAFA 316
Query: 328 IAVAHHLGHNLGMNHDEDT-CRCSQPRCIMHEGNPPITK------FSNCSYGDFWEYTVE 380
+ V L +LG+++D+ C+CS+ CIM NP + + FS+CS F +
Sbjct: 317 VIVTQMLALSLGISYDDPKKCQCSESTCIM---NPEVVQSNGVKTFSSCSLRSFQNFISN 373
Query: 381 -RTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCC-LSNCTLTDGSTCA 438
KCL + CGNG +E E CDCG C CC C L DG+ C
Sbjct: 374 VGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCY 433
Query: 439 FGLCCKDCKFLPSGKVCRKEVN-ECDLPEWCNGTSHKCPDDFYVEDGIPCKERGY-CYEK 496
GLCCKDC+ L SG CR + + ECD+ E CNG+S +C D + +G+ CK + CY+
Sbjct: 434 KGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFICYDG 493
Query: 497 SCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGI-KNATYIKCNISDVQCGRIQ 555
CHD + +C +FG G+ A CY+E+ + DR G+CG +N Y+ C ++ CGR+
Sbjct: 494 DCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLV 553
Query: 556 CENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHC 615
C T P ++ V +A D +C + DY L PD VK+G++C I +C++R C
Sbjct: 554 CTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNREC 613
Query: 616 VHITILNSN---CSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSV----DSGPPP 668
V I+ ++ CS C+ G+C++++ CHC+ + PPNC I+ G S+ D G
Sbjct: 614 VESRIIKASAHVCSQQ-CSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIM 672
Query: 669 KRKK-KKKFCYLCILLLIVLFILLCCLYRLCKK--SKPIKKQQDVQTPSAKEEEKIQRRP 725
+R K + +L L+ + +++ L +K K K+++ + +K E Q
Sbjct: 673 ERASGKTENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYA 732
Query: 726 HELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQ 760
+ + SQ T S+S Q S+S+
Sbjct: 733 SQSSSEGSTQTYASQ-----TRSESSSQADTSKSK 762
>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
sapiens]
Length = 735
Score = 335 bits (860), Expect = 8e-92
Identities = 204/708 (28%), Positives = 363/708 (51%), Gaps = 55/708 (7%)
Query: 53 SYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILE-DQPFVQNNCYYHGYVEGDPE 111
SY + G+ + +++ K L + V++Y+ G + DQ F QN C+Y GY+EG P+
Sbjct: 46 SYKIVIEGKPYTVNLMQKNFL-PHNFRVYSYSGTGIMKPLDQDF-QNFCHYQGYIEGYPK 103
Query: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQN-E 170
S+V +STC G +G+LQ + +Y I+PL S FEH++Y++ ++ S +++ +
Sbjct: 104 SVVMVSTCTG-LRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRD 162
Query: 171 ITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVN 230
++ +++ S + Q + + +E+ V+++ LY + + + + ++ ++
Sbjct: 163 LSFKLQ------SVEPQQDFA------KYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIG 210
Query: 231 IVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRMQHDTSHLF 289
+ ++I + ++L LE+W ++N I + + +H + +WK+ + R HD + L
Sbjct: 211 LTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLR-PHDVAFLL 269
Query: 290 TTLGLRGLSGIGAFRG-MCTPHRSCAIVTFMNK-TLGTFSIAVAHHLGHNLGMNHDE-DT 346
G F+G MC + + +V +L + ++ +A L ++G+ +D+ +
Sbjct: 270 VYREKSNYVG-ATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINK 328
Query: 347 CRCSQPRCIMHEGNPP------ITKFSNCSYGDFWEY-TVERTKCLLETVHTKDIFNVKR 399
C+CS CIM NP + FSNCS+ DF + + ++++CL F +
Sbjct: 329 CQCSGAVCIM---NPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQA 385
Query: 400 -CGNGVVEEGEECDCGPLKHCAK--DPCC-LSNCTLTDGSTCAFGLCCKDCKFLPSGKVC 455
CGN +E GEECDCG + CA + CC ++ C GS CA G CC++C F+ ++C
Sbjct: 386 VCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMC 445
Query: 456 RKEVNECDLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGAN 514
R ECDLPE+CNG+S CP++ YV+ G PC + C + C ++QC FG
Sbjct: 446 RPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVE 505
Query: 515 TASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWA 574
CY LN+ D G+CGI ++ Y +C ++QCG++ C+ V + T+ +A
Sbjct: 506 FGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYA 565
Query: 575 RFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRG 634
+ +C + ++ +KDGT CG + +C ++ CV + L +C+ CN RG
Sbjct: 566 NISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRG 625
Query: 635 ICNNKHHCHCNYLWDPPNCLIKG---YGGSVDSG--PP---PKRKKKKKFCYLC------ 680
+CNNK HCHC+ + PP+C ++ GGS+DSG PP P R ++++
Sbjct: 626 VCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPM 685
Query: 681 ---ILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEKIQRRP 725
L I FI+ C L + K +K+ + S+ E+ + + P
Sbjct: 686 RWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEP 733
>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
sapiens]
Length = 754
Score = 314 bits (805), Expect = 2e-85
Identities = 198/669 (29%), Positives = 327/669 (48%), Gaps = 40/669 (5%)
Query: 52 LSYILPFGGQKHIIHI-KVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDP 110
L Y + + ++H+ + ++ L S + F Y+ +G P + ++C+Y G + +
Sbjct: 59 LLYEIKLNRKTLVLHLLRSREFLGSNYSETF-YSMKGEAFTRHPQIMDHCFYQGSIVHEY 117
Query: 111 ESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNE 170
+S S+STC G +G +IND Y I+P+ +S EHLV+K + + + E
Sbjct: 118 DSAASISTC-NGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPY----GANYSCTE 172
Query: 171 ITCRMEFEEIDNSTQKQSSYVGWWIHF-RIVEIVVVIDNYLYIRYERNDSKLLEDLYVIV 229
+ + DN +++ S G IH + VE+ +V D+ +Y R +KL ++ +V
Sbjct: 173 LNFTRKTVPGDNESEEDSKIKG--IHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMV 230
Query: 230 NIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHL 288
N V+ I + + V L G+EIWT+++ I + ++ ++ + W+ + + R D L
Sbjct: 231 NFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVL 290
Query: 289 FTTLGLRG-LSGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTC 347
+ L + GI GMC P+ S +I+ + + +AH LGHNLGM HDE C
Sbjct: 291 LSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPC 350
Query: 348 RCSQPRCIMH-EGNPPITKFSNCSYGDFWEYTVE-RTKCLLETVHTKDIFNVKRCGNGVV 405
C +C+M +G+ P KFS CS + +Y + + C+L + + + CGN +
Sbjct: 351 TCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKL 410
Query: 406 EEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLP 465
+EGEECDCGP + C C C L G TCA G CC+ C+ +G +CR +ECD P
Sbjct: 411 DEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFP 470
Query: 466 EWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKEL 524
E C G S CP D + +G PCK GYC+ C R +QC +F A + + CYK +
Sbjct: 471 EMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICYK-M 529
Query: 525 NTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHW--ARFNDIMCW 582
NT G++ G+C K ++ C DV+CG+I C + + T H + N +
Sbjct: 530 NTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKC 589
Query: 583 STDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHI--TILNSNCSPAFCNKRGICNNKH 640
T + L DIG V GT+CG +C + C+++ +++NC P+ CN+ + +
Sbjct: 590 KTIF-LYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNC-PSQCNENPVDGHGL 647
Query: 641 HCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVL----FILLCCLYR 696
CHC P C + L ++L++V+ ++L YR
Sbjct: 648 QCHCEEGQAPVAC--------------EETLHVTNITILVVVLVLVIVGIGVLILLVRYR 693
Query: 697 LCKKSKPIK 705
C K K ++
Sbjct: 694 KCIKLKQVQ 702
>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
[Homo sapiens]
Length = 775
Score = 309 bits (792), Expect = 6e-84
Identities = 207/755 (27%), Positives = 343/755 (45%), Gaps = 65/755 (8%)
Query: 52 LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPE 111
L Y + G+ ++++K K L + Y G + P + ++CYY G++ +
Sbjct: 57 LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKV 116
Query: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLA--FSTTFEHLVYKMDSEEKQFSTMRSGFMQN 169
S S+STC G +G D Y I+PL+ EH ++K + +EK + +
Sbjct: 117 SDASISTC-RGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDS-------- 167
Query: 170 EITCRMEFEEIDNSTQKQSSYVGWWI----------HFRIVEIVVVIDNYLYIRYERNDS 219
TC M+ + Q+ + + H + +E +V+DN + RY N
Sbjct: 168 --TCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQD 225
Query: 220 KLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENIT 278
++ + ++ + N V+ + + V L G+EIWT+K+ I + + ++ + KW+ ++
Sbjct: 226 EIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLS 285
Query: 279 PRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHN 337
R +HD + L T L G + G+ MC+P+ S +V + L + +AH +GHN
Sbjct: 286 RRKRHDIAQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGTMAHEMGHN 344
Query: 338 LGMNHDEDTCRCSQPRCIMHEGNPPI--TKFSNCS---YGDFWEYTVERTKCLLETVHTK 392
GM HD+ +C+C C+M + T FS+CS Y F+E + + CL
Sbjct: 345 FGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKL--SNCLFNAPLPT 402
Query: 393 DIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSG 452
DI + CGN +VE GE+CDCG + C C C + CA G CC+ C+F +G
Sbjct: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAG 462
Query: 453 KVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSCHDRNEQCRRIFGA 511
VCR +ECDLPE CNG S CPDD + +G PC +G+C +C EQC ++G
Sbjct: 463 MVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGP 522
Query: 512 GANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTV 571
G A ++CY N G + G+C + T I C +D CG++ C+ SD+
Sbjct: 523 GTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQ------GGSDNLPW 575
Query: 572 HWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHI--TILNSNCSPAF 629
+ C + D +IG V +GT+CG + +CI+ CV I ++NCS +
Sbjct: 576 KGRIVTFLTCKTFDPE--DTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCS-SK 632
Query: 630 CNKRGICNNKHHCHCNYLWDPPNCLIKG--YGGSVDSGPPPKRKKKKKFCYLCILLLIVL 687
C +C+++ C C W PP+C + S+ G + + V+
Sbjct: 633 CKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVG--------------VLFPMAVI 678
Query: 688 FILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEKIQRRPH---ELPPQSQPWVMPSQSQPP 744
F+++ + R + KK Q + + K +R+P + PQ + P P
Sbjct: 679 FVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVKAVQPQEMSQMKPHVYDLP 738
Query: 745 VTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQP 779
V ++ + P T + P P S P
Sbjct: 739 VEGNEPPASFHKDTNALPPTVFKDNPVSTPKDSNP 773
>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
preproprotein [Homo sapiens]
Length = 813
Score = 306 bits (784), Expect = 5e-83
Identities = 234/825 (28%), Positives = 375/825 (45%), Gaps = 78/825 (9%)
Query: 3 MLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVI---PVRITGTTRGMTPPGWLSYILPFG 59
+LLLL L + +G +Q P P V+ P R ++ P L
Sbjct: 14 LLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAE 73
Query: 60 GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119
GQ+ ++ ++ L + Y G + P ++C+Y G V G P+S V L TC
Sbjct: 74 GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133
Query: 120 FGGFQGILQIN-DFAYEIKPLA------FSTTFEHLVYKMDSEEKQFSTMRSGFMQNEIT 172
G G++ ++ + +Y ++P FST H +++M+ Q T + +
Sbjct: 134 -SGMSGLITLSRNASYYLRPWPPRGSKDFST---HEIFRME----QLLTWKGTCGHRDPG 185
Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIV 232
+ + Q + + +E+ +V D+ L++ RN + + L + N V
Sbjct: 186 NKAGMTSLPGGPQSRGRREARRTR-KYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244
Query: 233 DSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291
D +L + ++V L GLE+WT ++ V D ++ + +W+ + + HD++ L T
Sbjct: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWR-RGLWAQRPHDSAQLLTG 303
Query: 292 LGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTC--- 347
+G + G+ GMC S + T ++ + +AH +GH+LG++HD D C
Sbjct: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVE 363
Query: 348 -RCSQPRCIMHE--GNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDI-FNVKRCGNG 403
C+M G+P FS CS + + L + CGNG
Sbjct: 364 AAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNG 423
Query: 404 VVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNEC 462
VE GEECDCGP + C +D CC + NC+L G+ CA G CC C P+G +CR+ + +C
Sbjct: 424 FVEAGEECDCGPGQEC-RDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDC 482
Query: 463 DLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGANTASETCY 521
DLPE+C GTS CP D Y+ DG PC + GYC++ +C +QC++++G G++ A E C+
Sbjct: 483 DLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACF 542
Query: 522 KELNTLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTE---IPNMSD-HTTVHWARF 576
+ +N+ GD G+CG ++ C D CG++QC+ P+M +TVH
Sbjct: 543 QVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH-LDG 601
Query: 577 NDIMCWST----DYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNK 632
++ C L + G +G V+ GT+CG +C R C C+
Sbjct: 602 QEVTCRGALALPSAQLDLLG--LGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHS 659
Query: 633 RGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILL- 691
G+CN+ H+CHC W PP C G+GGS+DSGP + + +L +LL VL LL
Sbjct: 660 HGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPV---QAENHDTFLLAMLLSVLLPLLP 716
Query: 692 -----CCLYRL-----------CKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQS--Q 733
C YRL C++ +D ++ P EL P + Q
Sbjct: 717 GAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKD---GPHRDHPLGGVHPMELGPTATGQ 773
Query: 734 PWVMPSQSQPPVTPSQSH-PQVMPSQSQPPVTPSQSQPRVMPSQS 777
PW P+ P SH P P + P V+P +V +S
Sbjct: 774 PW--------PLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRS 810
>gi|7656861 a disintegrin and metalloprotease domain 18
preproprotein [Homo sapiens]
Length = 739
Score = 306 bits (784), Expect = 5e-83
Identities = 198/634 (31%), Positives = 308/634 (48%), Gaps = 35/634 (5%)
Query: 54 YILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESL 113
YI+ GQ + +H+ + L L V+TY + G++ P+ +C+Y GY P S
Sbjct: 47 YIITIDGQPYTLHLGKQSFLPQNFL-VYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSF 105
Query: 114 VSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMR---SGFMQNE 170
V+LS C G +G LQ + +Y I+P+ S FEH++Y+M + + S + S Q +
Sbjct: 106 VTLSIC-SGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKD 164
Query: 171 ITCRMEFE-EIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIV 229
++ +I N ++ Y+ EI ++++ LY + + + ++
Sbjct: 165 QPYKVPLNSQIKNLSKLLPQYL---------EIYIIVEKALYDYMGSEMMAVTQKIVQVI 215
Query: 230 NIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRMQHDTSHL 288
+V+++ + V+L LE+W+N+N I D + + WK + + R HD ++L
Sbjct: 216 GLVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILR-PHDIAYL 274
Query: 289 FTTLGLRGLSGIGAFRGMCTPHRSCAIVTFMNKT-LGTFSIAVAHHLGHNLGMNHDEDT- 346
G +C I + + L FS+ +A LG N+G+ +D+ T
Sbjct: 275 LVYRKHPKYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQ 334
Query: 347 CRCSQPRCIM-HEGNPPITK--FSNCSYGDFWEYTVER--TKCLLETVHTKDIF-NVKRC 400
C C + CIM HE + FSNCS D+ Y V + TKCL + + + + N C
Sbjct: 335 CFCLRATCIMNHEAVSASGRKIFSNCSMHDY-RYFVSKFETKCLQKLSNLQPLHQNQPVC 393
Query: 401 GNGVVEEGEECDCGPLKHCAKDPCCLSN-CTLTDGSTCAFGLCCKD-CKFLPSGKVCRKE 458
GNG++E EECDCG C CC N C L C G CC C+ +G CRK
Sbjct: 394 GNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKS 453
Query: 459 VN-ECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTA 516
++ ECD E+CNGTS C D Y +G CK YCY C + QC +IFG GA A
Sbjct: 454 IDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGA 513
Query: 517 SETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARF 576
C+KE+N+L +R +CG KN+ + C DV CG++ C + N SD + ++
Sbjct: 514 PFACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYI 573
Query: 577 NDIMCWS--TDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAF-CNKR 633
D +C S T + G D V DGT CG + C+++ C + ++ NC+ C +
Sbjct: 574 QDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGK 633
Query: 634 GICNNKHHCHCNYLWDPPNCLIK--GYGGSVDSG 665
GICNN +C C PP+C + GGS+D G
Sbjct: 634 GICNNFGNCQCFPGHRPPDCKFQFGSPGGSIDDG 667
>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
Length = 856
Score = 291 bits (744), Expect = 2e-78
Identities = 229/802 (28%), Positives = 359/802 (44%), Gaps = 96/802 (11%)
Query: 32 DVVIPVRITGT-TRGMTP------PGWLSYILPFGGQKHIIHI-KVKKLLFSKHLPVFTY 83
+VV+P R+ G R P P +SY+L G +H+ K + LL S + +T
Sbjct: 30 EVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTA 89
Query: 84 TDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPL-AFS 142
+ G+ + +QP Q++C+Y G+VEG P+S SLSTC G +G Q+ + I+PL
Sbjct: 90 AN-GSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTC-AGLRGFFQVGSDLHLIEPLDEGG 147
Query: 143 TTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYV-----GWWI-- 195
H VY+ + +Q TC + + + + +++ V G +
Sbjct: 148 EGGRHAVYQAEH-----------LLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPS 196
Query: 196 -HFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNK 254
R VE+ VV+DN + + +++ + + +VN VD + + +V+L GLEIW ++
Sbjct: 197 RETRYVELYVVVDNAEF-QMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQ 255
Query: 255 NLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRS 312
+ V D ++ W++ T R HD L T + G + G MC+ H S
Sbjct: 256 DRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCS-HSS 314
Query: 313 CAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDT--CRCSQ----PRCIM--HEGNPPIT 364
A+ +K + +AH +GHNLGM+HDE+ CRC + RCIM G+
Sbjct: 315 GAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPR 374
Query: 365 KFSNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKD 422
FS+CS + E +ER + CL + CGN VE GE+CDCGP + C
Sbjct: 375 MFSDCSQA-YLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNR 433
Query: 423 PCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVE 482
C + C L +G+ CA G CC++CK P+G++CR + + CDL E+C+G +CP+D + E
Sbjct: 434 CCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQE 493
Query: 483 DGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYI 542
+G PC GYCY +C +QC+ +G G A E+C+ G + +
Sbjct: 494 NGTPC-SGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVL 552
Query: 543 KCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGT 602
+C GR C I ++ T G V +GT
Sbjct: 553 QCKGGQQPLGRAIC-----IVDVCHALTTE------------------DGTAYEPVPEGT 589
Query: 603 ECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSV 662
CG + +C C + + S+ A C+ G+CN+K CHC+ W PP+C
Sbjct: 590 RCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHA 649
Query: 663 DSGPPPKRKKKKKFCYLCILLLIVLFILLC--CLYRLCK---------------KSKPIK 705
SG P F + ++LL V+ + L +YR + +S P+
Sbjct: 650 ASGSLP------VFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLF 703
Query: 706 KQQDVQTPSAKEEEKIQRRPHELPPQS---QPWVMPSQSQPPVTPSQSHPQVMPSQSQP- 761
Q + P+ R P EL P + QP P+ S P + P + S P
Sbjct: 704 HQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPV 763
Query: 762 PVTPSQSQPRVMPSQSQPPVMP 783
PV Q+ +V+ PPV P
Sbjct: 764 PVYTRQAPKQVIKPTFAPPVPP 785
>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
preproprotein [Homo sapiens]
Length = 787
Score = 288 bits (737), Expect = 1e-77
Identities = 230/825 (27%), Positives = 369/825 (44%), Gaps = 104/825 (12%)
Query: 3 MLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVI---PVRITGTTRGMTPPGWLSYILPFG 59
+LLLL L + +G +Q P P V+ P R ++ P L
Sbjct: 14 LLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAE 73
Query: 60 GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119
GQ+ ++ ++ L + Y G + P ++C+Y G V G P+S V L TC
Sbjct: 74 GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133
Query: 120 FGGFQGILQIN-DFAYEIKPLA------FSTTFEHLVYKMDSEEKQFSTMRSGFMQNEIT 172
G G++ ++ + +Y ++P FST H +++M+ Q T + +
Sbjct: 134 -SGMSGLITLSRNASYYLRPWPPRGSKDFST---HEIFRME----QLLTWKGTCGHRDPG 185
Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIV 232
+ + Q + + +E+ +V D+ L++ RN + + L + N V
Sbjct: 186 NKAGMTSLPGGPQSRGRREARRTR-KYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244
Query: 233 DSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291
D +L + ++V L GLE+WT ++ V D ++ + +W+ + + HD++ L T
Sbjct: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWR-RGLWAQRPHDSAQLLTG 303
Query: 292 LGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTC--- 347
+G + G+ GMC S + T ++ + +AH +GH+LG++HD D C
Sbjct: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVE 363
Query: 348 -RCSQPRCIMHE--GNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDI-FNVKRCGNG 403
C+M G+P FS CS + + L + CGNG
Sbjct: 364 AAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNG 423
Query: 404 VVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNEC 462
VE GEECDCGP + C +D CC + NC+L G+ CA G CC C P+G +CR+ + +C
Sbjct: 424 FVEAGEECDCGPGQEC-RDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDC 482
Query: 463 DLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGANTASETCY 521
DLPE+C GTS CP D Y+ DG PC + GYC++ +C +QC++++G G++ A E C+
Sbjct: 483 DLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACF 542
Query: 522 KELNTLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTE---IPNMSD-HTTVHWARF 576
+ +N+ GD G+CG ++ C D CG++QC+ P+M +TVH
Sbjct: 543 QVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH-LDG 601
Query: 577 NDIMCWST----DYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNK 632
++ C L + G +G V+ GT+CG
Sbjct: 602 QEVTCRGALALPSAQLDLLG--LGLVEPGTQCG--------------------------P 633
Query: 633 RGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILL- 691
R +CN+ H+CHC W PP C G+GGS+DSGP + + +L +LL VL LL
Sbjct: 634 RMVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPV---QAENHDTFLLAMLLSVLLPLLP 690
Query: 692 -----CCLYRL-----------CKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQS--Q 733
C YRL C++ +D ++ P EL P + Q
Sbjct: 691 GAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKD---GPHRDHPLGGVHPMELGPTATGQ 747
Query: 734 PWVMPSQSQPPVTPSQSH-PQVMPSQSQPPVTPSQSQPRVMPSQS 777
PW P+ P SH P P + P V+P +V +S
Sbjct: 748 PW--------PLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRS 784
>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
preproprotein [Homo sapiens]
Length = 863
Score = 275 bits (702), Expect = 2e-73
Identities = 219/816 (26%), Positives = 349/816 (42%), Gaps = 89/816 (10%)
Query: 56 LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115
L G HI+ + + L + Y G + + NC Y G V G S VS
Sbjct: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
Query: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172
+ TC G ++ L T + + Q + S + T
Sbjct: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178
Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222
C + + E + TQK + H R VE+V+V D+ +Y R+ LL
Sbjct: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236
Query: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281
+ ++D+ + V+V L GLE WT ++L+ + + ++ + W+ ++ PR+
Sbjct: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296
Query: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340
HD++ L T G + G+ +C+P S + + ++ + ++AH LGH+LG+
Sbjct: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356
Query: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391
+HD ++C C P CIM P FSNCS + ++ CL E + +
Sbjct: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416
Query: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449
CGN VE GE+CDCG L C DPCC S C L G+ CA G CC++C+
Sbjct: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
Query: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508
PSG CR +CDLPE+C G S +CP D + DG PC + C C +QC+ +
Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
Query: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567
+G GA A+ C + NT G+ G CG + +Y+ C D CG++QC+ P +
Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
Query: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619
+ W + ++ C W HL + G D+ + GT CG +CI C +
Sbjct: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
Query: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679
+L + + C+ G+C++ HC+C W PP+C + K L
Sbjct: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699
Query: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQT-----PSAKEEEKIQRRPH 726
LL++++ ++L Y RLC+ P + + Q+ P + + R
Sbjct: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759
Query: 727 ELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQ------PP 780
+ S P PS+ PP S+ + + PP P + P V +SQ PP
Sbjct: 760 QASALSFP-APPSRPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPP 818
Query: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPP 816
P + PQ P + P ++PS+ PP
Sbjct: 819 RKPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 854
>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
preproprotein [Homo sapiens]
Length = 862
Score = 273 bits (699), Expect = 4e-73
Identities = 220/815 (26%), Positives = 350/815 (42%), Gaps = 88/815 (10%)
Query: 56 LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115
L G HI+ + + L + Y G + + NC Y G V G S VS
Sbjct: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
Query: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172
+ TC G ++ L T + + Q + S + T
Sbjct: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178
Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222
C + + E + TQK + H R VE+V+V D+ +Y R+ LL
Sbjct: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236
Query: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281
+ ++D+ + V+V L GLE WT ++L+ + + ++ + W+ ++ PR+
Sbjct: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296
Query: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340
HD++ L T G + G+ +C+P S + + ++ + ++AH LGH+LG+
Sbjct: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356
Query: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391
+HD ++C C P CIM P FSNCS + ++ CL E + +
Sbjct: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416
Query: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449
CGN VE GE+CDCG L C DPCC S C L G+ CA G CC++C+
Sbjct: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
Query: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508
PSG CR +CDLPE+C G S +CP D + DG PC + C C +QC+ +
Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
Query: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567
+G GA A+ C + NT G+ G CG + +Y+ C D CG++QC+ P +
Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
Query: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619
+ W + ++ C W HL + G D+ + GT CG +CI C +
Sbjct: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
Query: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679
+L + + C+ G+C++ HC+C W PP+C + K L
Sbjct: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699
Query: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQTPSAKEEEKIQR----RPHE 727
LL++++ ++L Y RLC+ P + + Q+ ++ QR R +
Sbjct: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759
Query: 728 LPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQ------PPV 781
S P PS+ PP S+ + + PP P + P V +SQ PP
Sbjct: 760 ASALSFP-APPSRPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPR 818
Query: 782 MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPP 816
P + PQ P + P ++PS+ PP
Sbjct: 819 KPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 853
>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
preproprotein [Homo sapiens]
Length = 838
Score = 271 bits (692), Expect = 2e-72
Identities = 215/805 (26%), Positives = 343/805 (42%), Gaps = 92/805 (11%)
Query: 56 LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115
L G HI+ + + L + Y G + + NC Y G V G S VS
Sbjct: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
Query: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172
+ TC G ++ L T + + Q + S + T
Sbjct: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178
Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222
C + + E + TQK + H R VE+V+V D+ +Y R+ LL
Sbjct: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236
Query: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281
+ ++D+ + V+V L GLE WT ++L+ + + ++ + W+ ++ PR+
Sbjct: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296
Query: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340
HD++ L T G + G+ +C+P S + + ++ + ++AH LGH+LG+
Sbjct: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356
Query: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391
+HD ++C C P CIM P FSNCS + ++ CL E + +
Sbjct: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416
Query: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449
CGN VE GE+CDCG L C DPCC S C L G+ CA G CC++C+
Sbjct: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
Query: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508
PSG CR +CDLPE+C G S +CP D + DG PC + C C +QC+ +
Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
Query: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567
+G GA A+ C + NT G+ G CG + +Y+ C D CG++QC+ P +
Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
Query: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619
+ W + ++ C W HL + G D+ + GT CG +CI C +
Sbjct: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
Query: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679
+L + + C+ G+C++ HC+C W PP+C + K L
Sbjct: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699
Query: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQ 731
LL++++ ++L Y RLC+ P + + Q+ ++ QR L +
Sbjct: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQR---ALLAR 756
Query: 732 SQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPPVMPSQSHPQLT 791
+ + PP P + P V +SQ P P PP P + PQ
Sbjct: 757 GTKAELADRPNPPTRPLPADPVVRSPKSQGPAKP------------PPPRKPLPADPQGR 804
Query: 792 PSQSQPPVTPSQRQPQLMPSQSQPP 816
P + P ++PS+ PP
Sbjct: 805 CPSGDLPGPGAGIPPLVVPSRPAPP 829
>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
preproprotein [Homo sapiens]
Length = 839
Score = 268 bits (686), Expect = 1e-71
Identities = 212/792 (26%), Positives = 340/792 (42%), Gaps = 83/792 (10%)
Query: 56 LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115
L G HI+ + + L + Y G + + NC Y G V G S VS
Sbjct: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
Query: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172
+ TC G ++ L T + + Q + S + T
Sbjct: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178
Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222
C + + E + TQK + H R VE+V+V D+ +Y R+ LL
Sbjct: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236
Query: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281
+ ++D+ + V+V L GLE WT ++L+ + + ++ + W+ ++ PR+
Sbjct: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296
Query: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340
HD++ L T G + G+ +C+P S + + ++ + ++AH LGH+LG+
Sbjct: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356
Query: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391
+HD ++C C P CIM P FSNCS + ++ CL E + +
Sbjct: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416
Query: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449
CGN VE GE+CDCG L C DPCC S C L G+ CA G CC++C+
Sbjct: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
Query: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508
PSG CR +CDLPE+C G S +CP D + DG PC + C C +QC+ +
Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
Query: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567
+G GA A+ C + NT G+ G CG + +Y+ C D CG++QC+ P +
Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
Query: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619
+ W + ++ C W HL + G D+ + GT CG +CI C +
Sbjct: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
Query: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679
+L + + C+ G+C++ HC+C W PP+C + K L
Sbjct: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699
Query: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQT-----PSAKEEEKIQRRPH 726
LL++++ ++L Y RLC+ P + + Q+ P + + R
Sbjct: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759
Query: 727 ELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPPVMPSQS 786
+ S P PS+ PP S+ P++ PP P + P+ P +
Sbjct: 760 QASALSFP-APPSRPLPPDPVSKRLQSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAGI 818
Query: 787 HPQLTPSQSQPP 798
P + PS+ PP
Sbjct: 819 PPLVVPSRPAPP 830
>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
preproprotein [Homo sapiens]
Length = 814
Score = 268 bits (685), Expect = 2e-71
Identities = 209/769 (27%), Positives = 334/769 (43%), Gaps = 80/769 (10%)
Query: 56 LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115
L G HI+ + + L + Y G + + NC Y G V G S VS
Sbjct: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
Query: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172
+ TC G ++ L T + + Q + S + T
Sbjct: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178
Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222
C + + E + TQK + H R VE+V+V D+ +Y R+ LL
Sbjct: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236
Query: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281
+ ++D+ + V+V L GLE WT ++L+ + + ++ + W+ ++ PR+
Sbjct: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296
Query: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340
HD++ L T G + G+ +C+P S + + ++ + ++AH LGH+LG+
Sbjct: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356
Query: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391
+HD ++C C P CIM P FSNCS + ++ CL E + +
Sbjct: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416
Query: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449
CGN VE GE+CDCG L C DPCC S C L G+ CA G CC++C+
Sbjct: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
Query: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508
PSG CR +CDLPE+C G S +CP D + DG PC + C C +QC+ +
Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
Query: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567
+G GA A+ C + NT G+ G CG + +Y+ C D CG++QC+ P +
Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
Query: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619
+ W + ++ C W HL + G D+ + GT CG +CI C +
Sbjct: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
Query: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679
+L + + C+ G+C++ HC+C W PP+C + K L
Sbjct: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699
Query: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQ 731
LL++++ ++L Y RLC+ P + + Q+ ++ QR +
Sbjct: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759
Query: 732 SQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780
SQ P++ PP P + PQ P + P V+PS+ PP
Sbjct: 760 SQG---PAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 805
>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
sapiens]
Length = 832
Score = 260 bits (664), Expect = 4e-69
Identities = 180/606 (29%), Positives = 291/606 (48%), Gaps = 44/606 (7%)
Query: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAF-----STTFEHLVYK-- 151
+CYYHG + G +S V+LSTC G G+ + + F Y I+PL ST H++ K
Sbjct: 195 HCYYHGSIRGVKDSKVALSTC-NGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTL 253
Query: 152 --MDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNY 209
S++ + TM G ++ E + + + + G + + +E+++V D+
Sbjct: 254 AGQYSKQMKNLTMERG---DQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHK 310
Query: 210 LYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVH 267
Y ++ + + +VN+VDSI + + +V+L +E WT K+ I + + + +H
Sbjct: 311 TYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLH 370
Query: 268 LYCKWKSENITPRMQHDTSHLFTTLGLR-GLSGIGAFRGMCTPHRSCAIVTF--MNKTLG 324
+ K++ + D HL + + S + F G+C+ R + +
Sbjct: 371 EFSKYRQRI---KQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQ 427
Query: 325 TFSIAVAHHLGHNLGMNHDEDTCRCSQP--RCIMHE-GNPPITKFSNCSYGDFWEYTVER 381
S ++A +LG + + C C++ CIM E G KFS CS ++ ++
Sbjct: 428 VLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRG 487
Query: 382 TKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGL 441
L TK +F CGNG VE GEECDCG C C C+L++G+ C+ G
Sbjct: 488 GGACLFNRPTK-LFEPTECGNGYVEAGEECDCGFHVECYG--LCCKKCSLSNGAHCSDGP 544
Query: 442 CCKD--CKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSC 498
CC + C F P G CR VNECD+ E+C G S +CP + + +DG C + +G CY C
Sbjct: 545 CCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGEC 604
Query: 499 HDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCEN 558
R+ QC+ I+G A + + CY++LNT G G+CG +I+C+ DV CG + C N
Sbjct: 605 KTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTN 664
Query: 559 VTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHR 613
+T P + T + + I C L D+G V+DGT CG +C+ R
Sbjct: 665 LTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLD-DDTDVGYVEDGTPCGPSMMCLDR 723
Query: 614 HCVHITILNSNCSP-----AFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPP 668
C+ I LN + P C+ G+C+N+ C C++ W +C I+ V + PP
Sbjct: 724 KCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIR---DPVRNLHPP 780
Query: 669 KRKKKK 674
K + K
Sbjct: 781 KDEGPK 786
>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
[Homo sapiens]
Length = 906
Score = 258 bits (660), Expect = 1e-68
Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)
Query: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154
+CYY G++ G+P+S V+LSTC G G+ + Y I+P TT E H VYK
Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192
Query: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202
E + S F Q IT + + + ++++ Y+ E+
Sbjct: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243
Query: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260
++V D+ ++ ++ + +VN+ D I D + +++L +E W N + +
Sbjct: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303
Query: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319
+ ++ + K++ + I + + D HLF+ SG G+C+ + + F
Sbjct: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361
Query: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371
L ++ +A L HN+G+ D+ C+C CIM + G KF+ C+
Sbjct: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419
Query: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430
++ ++ L +K + + CGNG +E GEECDCG C + C CT
Sbjct: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478
Query: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489
LT S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C + + DG C
Sbjct: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538
Query: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549
+G C+ C R+ QC+ I+G + + CY++LN G G+CG T+I+CN DV
Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598
Query: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604
CG + C N+ IP + + +T+ + + C L + D+G V+DGT C
Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657
Query: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653
G +C+ C+ + N S+ C+ G+C+N+ C CN W +C
Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
[Homo sapiens]
Length = 899
Score = 258 bits (660), Expect = 1e-68
Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)
Query: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154
+CYY G++ G+P+S V+LSTC G G+ + Y I+P TT E H VYK
Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192
Query: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202
E + S F Q IT + + + ++++ Y+ E+
Sbjct: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243
Query: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260
++V D+ ++ ++ + +VN+ D I D + +++L +E W N + +
Sbjct: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303
Query: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319
+ ++ + K++ + I + + D HLF+ SG G+C+ + + F
Sbjct: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361
Query: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371
L ++ +A L HN+G+ D+ C+C CIM + G KF+ C+
Sbjct: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419
Query: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430
++ ++ L +K + + CGNG +E GEECDCG C + C CT
Sbjct: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478
Query: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489
LT S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C + + DG C
Sbjct: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538
Query: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549
+G C+ C R+ QC+ I+G + + CY++LN G G+CG T+I+CN DV
Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598
Query: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604
CG + C N+ IP + + +T+ + + C L + D+G V+DGT C
Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657
Query: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653
G +C+ C+ + N S+ C+ G+C+N+ C CN W +C
Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
[Homo sapiens]
Length = 823
Score = 258 bits (660), Expect = 1e-68
Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)
Query: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154
+CYY G++ G+P+S V+LSTC G G+ + Y I+P TT E H VYK
Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192
Query: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202
E + S F Q IT + + + ++++ Y+ E+
Sbjct: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243
Query: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260
++V D+ ++ ++ + +VN+ D I D + +++L +E W N + +
Sbjct: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303
Query: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319
+ ++ + K++ + I + + D HLF+ SG G+C+ + + F
Sbjct: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361
Query: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371
L ++ +A L HN+G+ D+ C+C CIM + G KF+ C+
Sbjct: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419
Query: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430
++ ++ L +K + + CGNG +E GEECDCG C + C CT
Sbjct: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478
Query: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489
LT S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C + + DG C
Sbjct: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538
Query: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549
+G C+ C R+ QC+ I+G + + CY++LN G G+CG T+I+CN DV
Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598
Query: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604
CG + C N+ IP + + +T+ + + C L + D+G V+DGT C
Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657
Query: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653
G +C+ C+ + N S+ C+ G+C+N+ C CN W +C
Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
[Homo sapiens]
Length = 870
Score = 258 bits (660), Expect = 1e-68
Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)
Query: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154
+CYY G++ G+P+S V+LSTC G G+ + Y I+P TT E H VYK
Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192
Query: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202
E + S F Q IT + + + ++++ Y+ E+
Sbjct: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243
Query: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260
++V D+ ++ ++ + +VN+ D I D + +++L +E W N + +
Sbjct: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303
Query: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319
+ ++ + K++ + I + + D HLF+ SG G+C+ + + F
Sbjct: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361
Query: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371
L ++ +A L HN+G+ D+ C+C CIM + G KF+ C+
Sbjct: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419
Query: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430
++ ++ L +K + + CGNG +E GEECDCG C + C CT
Sbjct: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478
Query: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489
LT S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C + + DG C
Sbjct: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538
Query: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549
+G C+ C R+ QC+ I+G + + CY++LN G G+CG T+I+CN DV
Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598
Query: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604
CG + C N+ IP + + +T+ + + C L + D+G V+DGT C
Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657
Query: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653
G +C+ C+ + N S+ C+ G+C+N+ C CN W +C
Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
[Homo sapiens]
Length = 859
Score = 258 bits (660), Expect = 1e-68
Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)
Query: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154
+CYY G++ G+P+S V+LSTC G G+ + Y I+P TT E H VYK
Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192
Query: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202
E + S F Q IT + + + ++++ Y+ E+
Sbjct: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243
Query: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260
++V D+ ++ ++ + +VN+ D I D + +++L +E W N + +
Sbjct: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303
Query: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319
+ ++ + K++ + I + + D HLF+ SG G+C+ + + F
Sbjct: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361
Query: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371
L ++ +A L HN+G+ D+ C+C CIM + G KF+ C+
Sbjct: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419
Query: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430
++ ++ L +K + + CGNG +E GEECDCG C + C CT
Sbjct: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478
Query: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489
LT S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C + + DG C
Sbjct: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538
Query: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549
+G C+ C R+ QC+ I+G + + CY++LN G G+CG T+I+CN DV
Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598
Query: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604
CG + C N+ IP + + +T+ + + C L + D+G V+DGT C
Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657
Query: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653
G +C+ C+ + N S+ C+ G+C+N+ C CN W +C
Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.456
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,400,739
Number of Sequences: 37866
Number of extensions: 2110461
Number of successful extensions: 19947
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 233
Number of HSP's successfully gapped in prelim test: 818
Number of HSP's that attempted gapping in prelim test: 10269
Number of HSP's gapped (non-prelim): 5796
length of query: 820
length of database: 18,247,518
effective HSP length: 111
effective length of query: 709
effective length of database: 14,044,392
effective search space: 9957473928
effective search space used: 9957473928
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.