BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo sapiens] (820 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo... 1767 0.0 gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo... 1767 0.0 gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo... 1767 0.0 gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ... 1767 0.0 gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ... 810 0.0 gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ... 782 0.0 gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H... 515 e-146 gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ... 491 e-138 gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot... 363 e-100 gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ... 361 2e-99 gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot... 355 1e-97 gi|148664238 a disintegrin and metalloprotease domain 32 [Homo s... 337 3e-92 gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi... 335 8e-92 gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ... 314 2e-85 gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot... 309 6e-84 gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro... 306 5e-83 gi|7656861 a disintegrin and metalloprotease domain 18 prepropro... 306 5e-83 gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens] 291 2e-78 gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop... 288 1e-77 gi|46909600 a disintegrin and metalloproteinase domain 15 isofor... 275 2e-73 gi|46909598 a disintegrin and metalloproteinase domain 15 isofor... 273 4e-73 gi|46909596 a disintegrin and metalloproteinase domain 15 isofor... 271 2e-72 gi|46909594 a disintegrin and metalloproteinase domain 15 isofor... 268 1e-71 gi|46909590 a disintegrin and metalloproteinase domain 15 isofor... 268 2e-71 gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s... 260 4e-69 gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot... 258 1e-68 gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot... 258 1e-68 gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot... 258 1e-68 gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot... 258 1e-68 gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote... 258 1e-68 >gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo sapiens] Length = 820 Score = 1767 bits (4576), Expect = 0.0 Identities = 820/820 (100%), Positives = 820/820 (100%) Query: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG Sbjct: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60 Query: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120 Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180 Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240 Query: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI Sbjct: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300 Query: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN Sbjct: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360 Query: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA Sbjct: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420 Query: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY Sbjct: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480 Query: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT Sbjct: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540 Query: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD Sbjct: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600 Query: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG Sbjct: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660 Query: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK Sbjct: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720 Query: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP Sbjct: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780 Query: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS Sbjct: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820 >gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo sapiens] Length = 820 Score = 1767 bits (4576), Expect = 0.0 Identities = 820/820 (100%), Positives = 820/820 (100%) Query: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG Sbjct: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60 Query: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120 Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180 Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240 Query: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI Sbjct: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300 Query: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN Sbjct: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360 Query: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA Sbjct: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420 Query: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY Sbjct: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480 Query: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT Sbjct: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540 Query: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD Sbjct: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600 Query: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG Sbjct: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660 Query: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK Sbjct: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720 Query: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP Sbjct: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780 Query: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS Sbjct: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820 >gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo sapiens] Length = 820 Score = 1767 bits (4576), Expect = 0.0 Identities = 820/820 (100%), Positives = 820/820 (100%) Query: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG Sbjct: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60 Query: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120 Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180 Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240 Query: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI Sbjct: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300 Query: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN Sbjct: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360 Query: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA Sbjct: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420 Query: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY Sbjct: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480 Query: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT Sbjct: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540 Query: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD Sbjct: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600 Query: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG Sbjct: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660 Query: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK Sbjct: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720 Query: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP Sbjct: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780 Query: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS Sbjct: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820 >gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo sapiens] Length = 820 Score = 1767 bits (4576), Expect = 0.0 Identities = 820/820 (100%), Positives = 820/820 (100%) Query: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG Sbjct: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60 Query: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120 Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180 Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240 Query: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI Sbjct: 241 VKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI 300 Query: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN Sbjct: 301 GAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGN 360 Query: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA Sbjct: 361 PPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCA 420 Query: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY Sbjct: 421 KDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFY 480 Query: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT Sbjct: 481 VEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNAT 540 Query: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD Sbjct: 541 YIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKD 600 Query: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG Sbjct: 601 GTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGG 660 Query: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK Sbjct: 661 SVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEK 720 Query: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP Sbjct: 721 IQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780 Query: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS Sbjct: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTPS 820 >gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo sapiens] Length = 776 Score = 810 bits (2091), Expect = 0.0 Identities = 378/718 (52%), Positives = 488/718 (67%), Gaps = 11/718 (1%) Query: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60 +++ LLL G+FLS SGH Q QY + P+VVIP+++ RG PGWLSY L FGG Sbjct: 60 IRVTLLLLWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGG 119 Query: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120 Q++I+H++V KLLF+ HLPVFTYT+Q A+L+DQPF+Q++CYYHGYVEG PESLV+LSTC Sbjct: 120 QRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCS 179 Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180 GGF G+LQIND YEIKP++ S TFEHLVYK+DS++ QF MR G + +I +ME + Sbjct: 180 GGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLS 239 Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240 N T KQSS+VGWW H R VE+VVV+DN Y+ + N + + +++ +VNIVDS + Sbjct: 240 YNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLE 299 Query: 241 VKVLLFGLEIWTNKN-LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFT--TLGLRGL 297 V V+L G++IWT N L D+ + + WK+ N+ R+QHD +HLF T G++ Sbjct: 300 VDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMK-- 357 Query: 298 SGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMH 357 G+ +G+C + + F + L F+I + H LGHNLGM HD C C CIMH Sbjct: 358 LGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVCELQWCIMH 417 Query: 358 EGNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLK 417 TKFSNCSY +W+ T+ C+ + +IF +K CGN VVEEGEECDCG ++ Sbjct: 418 AYRKVTTKFSNCSYAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIR 477 Query: 418 HCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPD 477 CAKDPCCL NCTL G+ CAFG+CCKDCKFLPSG +CR++V ECDLPEWCNGTSH+CPD Sbjct: 478 QCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPD 537 Query: 478 DFYVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIK 537 D YV+DGI C +CYEK+C++ + QC+ IFG A +AS++CY+E+NT G+R GHCGI Sbjct: 538 DVYVQDGISCNVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIV 597 Query: 538 NATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597 TY+KC D+ CGR+QCENV IPN+ +H+TV ND CW TDYHLGM PDIGE Sbjct: 598 GTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIPDIGE 657 Query: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657 VKDGT CG + ICI + C + L+ C P CN RGICNNK HCHCN+ W PP C KG Sbjct: 658 VKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAPPYCKDKG 717 Query: 658 YGGSVDSGPPPKRKKK-----KKFCYLCILLLIVLF-ILLCCLYRLCKKSKPIKKQQD 709 YGGS DSGPPPK + K YL +L L+ L LL CL+ L KK K+ ++ Sbjct: 718 YGGSADSGPPPKNNMEGLNVMGKLRYLSLLCLLPLVAFLLFCLHVLFKKRTKSKEDEE 775 >gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo sapiens] Length = 722 Score = 782 bits (2019), Expect = 0.0 Identities = 357/711 (50%), Positives = 481/711 (67%), Gaps = 9/711 (1%) Query: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60 +++ LLL LGVFLS SG+ Q Q+ + P+VVIP+++ R PGWLSY L FGG Sbjct: 10 IRVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYSLRFGG 69 Query: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120 QKH++H++VKKLL S+HLPVFTYTD+ A+LEDQ F+ ++CYYHGYVEG PESLV S CF Sbjct: 70 QKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPESLVVFSACF 129 Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCR-MEFEE 179 GGF+G+L+I+ YEI+P+ S TFEHLVYK++S E QF MR G + E+ + +EFEE Sbjct: 130 GGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQLEFEE 189 Query: 180 IDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVI 239 +NS + S WW H +E+VVV+++ +I + N SK+ ED++++VNIVDS+ + Sbjct: 190 AENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQL 249 Query: 240 GVKVLLFGLEIWTNKNLIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSG 299 G ++L G+EIW N+ + + + ++ + +WK +++ ++QHD +H+F L + G Sbjct: 250 GTYIILIGIEIWNQGNVFPMTSIEQVLNDFSQWKQISLS-QLQHDAAHMFIKNSLISILG 308 Query: 300 IGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEG 359 + G+C P C + F T F+ VAH LGH LGM HDE+ C C + CIM+ Sbjct: 309 LAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFCGERGCIMNTF 368 Query: 360 NPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHC 419 P KF+NCSY DF + T+ + CL +IF +KRCGNGVVE E+CDCG ++ C Sbjct: 369 RVPAEKFTNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQC 428 Query: 420 AKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDF 479 +D CCL NCTL G+ CAFGLCCKDCKF+PSG++CR+EVNECDLPEWCNGTSH+CP+D Sbjct: 429 EQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDR 488 Query: 480 YVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNA 539 YV+DGIPC + YCY+K C++ ++ CR IFG A +AS+ CYKE+N+ G+R GHCGI Sbjct: 489 YVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGT 548 Query: 540 TYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVK 599 TY+KC+ISDV CGR+QCENV +IP + DH T+ N + CW DYHL M DIGEVK Sbjct: 549 TYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMNISDIGEVK 608 Query: 600 DGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYG 659 DGT CG ICIH+ CV +++L+ C P CN +GICNNKHHCHC Y W PP C +GYG Sbjct: 609 DGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYG 668 Query: 660 GSVDSGPPPKRKKKKKFCYLCIL----LLIVLFILLCCLY-RLCKKSKPIK 705 GS+DSG P K+ F L ++ +L LF + +Y R C K K Sbjct: 669 GSIDSG--PASAKRGVFLPLIVIPSLSVLTFLFTVGLLMYLRQCSGPKETK 717 >gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo sapiens] Length = 819 Score = 515 bits (1326), Expect = e-146 Identities = 281/803 (34%), Positives = 430/803 (53%), Gaps = 30/803 (3%) Query: 1 MKMLLLLHCLGVFLSCS--GHIQDEHPQYHSPPDVVIPVRITGTTRGMTPP--GWLSYIL 56 ++ LLLL +G L + G Q H + +++ P R+T R P +SY++ Sbjct: 14 VRWLLLLGLVGPVLGAARPGFQQTSHLSSY---EIITPWRLTRERREAPRPYSKQVSYVI 70 Query: 57 PFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSL 116 G++HIIH++ K L + V+TY +G ++ D P +QN+C+Y GYVEG S ++L Sbjct: 71 QAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIAL 130 Query: 117 STCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---TC 173 S CFG +G+L + + +Y I+PL S+ FEH++Y+MD K+ ++ G +I T Sbjct: 131 SDCFG-LRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKE--PLKCGVSNKDIEKETA 187 Query: 174 RMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVD 233 + E EE + TQ R VE+ +V+D Y RN + + E++ ++ N +D Sbjct: 188 KDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLD 247 Query: 234 SILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTL 292 S+ ++ ++++L GLEIWTN NLI +V + + +W+ + + R +HD++ L Sbjct: 248 SMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKK 307 Query: 293 GLRGLSGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDT-CRCSQ 351 G G +G+ +C+ + I F T+ TF+ VAH LGHNLGMNHD+ C C Sbjct: 308 GFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGA 367 Query: 352 PRCIMHEGNPPITKFSNCSYGDFWEYTVERT-KCLLETVHTKDIFNVKRCGNGVVEEGEE 410 CIM+ G FS+CS DF + T+ + CLL + ++ CGN +V+ GEE Sbjct: 368 KSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEE 427 Query: 411 CDCGPLKHCAKDPCCL-SNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCN 469 CDCG K C DPCC S C L + CA+G CCKDC+FLP G +CR + +ECD+PE+CN Sbjct: 428 CDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCN 487 Query: 470 GTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLG 528 G+S C D ++++G PC+ + YCY C + QC+ IFG+ A A + C+ E+N+ G Sbjct: 488 GSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKG 547 Query: 529 DRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHL 588 DR G+CG Y KC + CG++QCENV EIP + CW D+ L Sbjct: 548 DRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQL 607 Query: 589 GMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCS-PAFCNKRGICNNKHHCHCNYL 647 G PD G V +GT+CG IC + CV ++LN +C C+ G+CN+ +CHC Sbjct: 608 GSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENG 667 Query: 648 WDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCK-----KSK 702 W PPNC KGYGGSVDSGP L + +++ +++C ++ K +S Sbjct: 668 WAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSY 727 Query: 703 PIKKQQDVQTPSAKEEEKIQRRPHELP----PQSQPWVMPSQSQPPVTPSQS--HPQVMP 756 KK+ K + R+P +P P + P +P + P+ + PQ P Sbjct: 728 FRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAAKQPQQFP 787 Query: 757 SQSQPPVTPSQSQPRVMPSQSQP 779 S+ PP SQ ++P++ P Sbjct: 788 SRPPPPQPKVSSQGNLIPARPAP 810 >gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo sapiens] Length = 790 Score = 491 bits (1263), Expect = e-138 Identities = 267/793 (33%), Positives = 432/793 (54%), Gaps = 33/793 (4%) Query: 4 LLLLHCLGVFLSCSGHIQDEHPQYHSPP-DVVIPVRIT--GTTRGMTPPGWLSYILPFGG 60 LLLL + L G HP+ +V IP +++ G +G+ P +SY+L G Sbjct: 13 LLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSP--VSYLLQLKG 70 Query: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120 +KH++H+ K+LL +HL VF++T+ G +LED P++ +C Y G V+ +S ++STC Sbjct: 71 KKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCM 130 Query: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180 GG +G+ I+ Y+I+PL S +FEH+VY + E QF G +EI +M E Sbjct: 131 GGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKE--QFGNQVCGLSDDEIEWQMAPYE- 187 Query: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240 + + + G + H + +E++++ D Y N S+++ D ++ I+D+ + Sbjct: 188 --NKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVR 245 Query: 241 VKVLLFGLEIWTNKNLIVVD--DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS 298 +++ L LE+WT+ N I V ++ + + + +K + R+ D +HL+ Sbjct: 246 MRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDAL 305 Query: 299 GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRC-SQPRCIMH 357 +F +C+ + ++ T ++ + + AH LGH +GM+HDE C+C + CIM Sbjct: 306 A-WSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLNCIMG 364 Query: 358 EGNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLK 417 G T FSNCSY F+++ CL + +KRCGN +VE+ EECDCG + Sbjct: 365 SGR---TGFSNCSYISFFKHISSGATCLNNIPGLGYV--LKRCGNKIVEDNEECDCGSTE 419 Query: 418 HCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPD 477 C KD CC SNC L G+ C+ GLCC DC+F PSG VCR+E NECDL E+C+G S CP+ Sbjct: 420 ECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPN 479 Query: 478 DFYVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHC--- 534 D Y +DG PCK G C+ K C R QC+ IFG A A CY +N +GD+ G+C Sbjct: 480 DVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEIT 539 Query: 535 GIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTV--HWARFNDIMCWSTDYHLGMKG 592 GI+N + KC ++ CGR+QC NV IP++ +HTT+ + ++MCW T YHL MK Sbjct: 540 GIRN--FKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKP 597 Query: 593 ---PDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWD 649 PD+G + DGT CG +C ++CV+ ++L +C P CN RG+CNN+ +CHC Y W Sbjct: 598 MGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWA 657 Query: 650 PPNCLIKGYGGSVDSGPPP--KRKKKKKFCYLCILLLIVLFILLCCLYRLCKK--SKPIK 705 PP C GYGGS+DSGPP + + I++ ++ ++L ++ ++ +K Sbjct: 658 PPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLK 717 Query: 706 KQQDVQTPSAKEEEKIQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTP 765 +Q+ S + E+ + + + +S+ +S+ +S + +S+ + Sbjct: 718 PKQEKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIES 777 Query: 766 SQSQPRVMPSQSQ 778 + + + + Q + Sbjct: 778 KRPKAKSVKKQKK 790 >gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein [Homo sapiens] Length = 909 Score = 363 bits (931), Expect = e-100 Identities = 246/850 (28%), Positives = 396/850 (46%), Gaps = 88/850 (10%) Query: 32 DVVIPVRITGTTRGMTPPGWLSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQG---A 88 D+ IPV+ + P L+ L ++ II+++ + L + Y G + Sbjct: 51 DLWIPVK---SFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVS 107 Query: 89 ILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHL 148 + + + +CYYHG+V G +S VSLSTC G +G++ + +Y ++P+ +T Sbjct: 108 LARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFENESYVLEPMKSATN---- 162 Query: 149 VYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI------------DNSTQKQSSYVGWWIH 196 YK+ K+ ++R + T + + + T K + Y Sbjct: 163 RYKL-FPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKY------ 215 Query: 197 FRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKN- 255 VE+V+V DN + R ++ K+ + L I N VD + ++++L G+E+W + + Sbjct: 216 ---VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDK 272 Query: 256 LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCA 314 V D S+H + W+ + PR HD + L + + +G + G+ MCT +S Sbjct: 273 CSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGG 332 Query: 315 IVTFMNKTLGTFSIAVAHHLGHNLGMNHD--EDTCRC----SQPRCIMH--EGNPPITKF 366 IV + ++ +AH LGHN GMNHD + C C + CIM+ G P F Sbjct: 333 IVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVF 392 Query: 367 SNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC 424 S+CS D E ++E+ CL ++ F ++CGN VEEGEECDCG + C C Sbjct: 393 SSCSRKDL-ETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCC 451 Query: 425 CLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDG 484 + CTL + CA GLCC+DC+ P+G CR N CDLPE+C G S CP + Y+ DG Sbjct: 452 NATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDG 511 Query: 485 IPCKE-RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCG-IKNATYI 542 C++ GYCY C +QC ++G GA A C++ +N+ GD G+CG + +++ Sbjct: 512 HSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFA 571 Query: 543 KCNISDVQCGRIQCENVTEIP-----NMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597 KC + D +CG+IQC+ P +S T + + I+C T +LG PD G Sbjct: 572 KCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGL 631 Query: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657 V GT+C IC++R C +I++ + C+ RG+CNN+ +CHC W PP C G Sbjct: 632 VLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFG 691 Query: 658 YGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLY---------------------- 695 +GGS DSGP + + L I +L+ + LL + Sbjct: 692 FGGSTDSGPIRQADNQG----LTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIE 747 Query: 696 --RLCKKSKPIKKQQDVQTPSAKEEEKIQRRPHE-LPPQSQP-WVMPSQSQPPVTPSQSH 751 R + S+P + Q Q + + R+P + PP+ P ++ Q+ P Sbjct: 748 KLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGL 807 Query: 752 PQVMPSQSQPPVTPSQSQPR-----VMPSQSQPPVMPSQSHPQLTPSQSQPPVTPSQRQP 806 P +Q + P PR P ++P + +Q + P Q P P R Sbjct: 808 NVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTT 867 Query: 807 QLMPSQSQPP 816 +L + ++ P Sbjct: 868 RLTHALARTP 877 >gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo sapiens] Length = 918 Score = 361 bits (926), Expect = 2e-99 Identities = 244/821 (29%), Positives = 386/821 (47%), Gaps = 70/821 (8%) Query: 60 GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119 G++ I+ ++ + LF+ YT G ++++C+YHG V S V+LSTC Sbjct: 73 GRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTC 132 Query: 120 FGGFQGILQIN-DFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFE 178 G +G++ ++ + +Y I+PL S +HL+Y+ SE + GF ++ T R Sbjct: 133 -RGIRGLITVSSNLSYVIEPLPDSKG-QHLIYR--SEHLKPPPGNCGFEHSKPTTRDWAL 188 Query: 179 EIDNSTQKQSSYVGW--WIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL 236 + T+K+ + + VE+ +V D + + R+ L I N VD Sbjct: 189 QFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFY 248 Query: 237 DVIGVKVLLFGLEIWTNKNLIVV-DDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLR 295 + +++ L GLE+WT+ N+ V ++ ++ + W+ + + + HD + L T + Sbjct: 249 RSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKY-HDNAQLITGMSFH 307 Query: 296 GLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPR- 353 G + G+ MC+ ++S + ++ + +AH +GHN GM HD C CS Sbjct: 308 GTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADC-CSASAA 366 Query: 354 ---CIMHE--GNPPITKFSNCSYGDFWEYTVERT-KCLLETVHTKDIFNVKRCGNGVVEE 407 CIM G+P F+ C+ + Y CL T+ ++ +RCGNG +E+ Sbjct: 367 DGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLED 426 Query: 408 GEECDCGPLKHCAKDPCC-LSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPE 466 GEECDCG + C +PCC SNCTL G+ CA G CC CK L G +CR++ +CDLPE Sbjct: 427 GEECDCGEEEEC-NNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDLPE 485 Query: 467 WCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELN 525 +C G S CP +FY DG PC+ + YCY C EQC++++G GA A + C++++N Sbjct: 486 FCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVN 545 Query: 526 TLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWA---RFNDIMC 581 GD G+CG N + KCN+ D +CG+IQC++ P S+ + I C Sbjct: 546 VAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQC 605 Query: 582 WSTDYHLGMKGP----DIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICN 637 T + G + D G V GT+CG +HIC C + + + CN G+CN Sbjct: 606 RGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCN 665 Query: 638 NKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILL---CC- 693 N +CHC W PP C G+GGS+DSGP P + + +L++ ++L CC Sbjct: 666 NNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLMYYCCR 725 Query: 694 ----LYRLCKKSKPIKKQQD---------------------VQTPSAKEE----EKIQRR 724 L +L + P K +Q +QTP K + +I R+ Sbjct: 726 QNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTPEILRK 785 Query: 725 PHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPP---VTPSQSQPRVMPSQSQPPV 781 P + PP+ P + S P P +H S P + ++S R PS+ PP Sbjct: 786 PSQPPPRPPPDYLRGGSPP--APLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIPPA 843 Query: 782 ---MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTP 819 + SQ + P Q P P + L P+ P Sbjct: 844 PNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRP 884 >gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein [Homo sapiens] Length = 738 Score = 355 bits (910), Expect = 1e-97 Identities = 214/669 (31%), Positives = 336/669 (50%), Gaps = 53/669 (7%) Query: 32 DVVIPVRITGTTRGMTPPGWLSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQG---A 88 D+ IPV+ + P L+ L ++ II+++ + L + Y G + Sbjct: 51 DLWIPVK---SFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVS 107 Query: 89 ILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHL 148 + + + +CYYHG+V G +S VSLSTC G +G++ + +Y ++P+ +T Sbjct: 108 LARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFENESYVLEPMKSATN---- 162 Query: 149 VYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI------------DNSTQKQSSYVGWWIH 196 YK+ K+ ++R + T + + + T K + Y Sbjct: 163 RYKL-FPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKY------ 215 Query: 197 FRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKN- 255 VE+V+V DN + R ++ K+ + L I N VD + ++++L G+E+W + + Sbjct: 216 ---VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDK 272 Query: 256 LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCA 314 V D S+H + W+ + PR HD + L + + +G + G+ MCT +S Sbjct: 273 CSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGG 332 Query: 315 IVTFMNKTLGTFSIAVAHHLGHNLGMNHD--EDTCRC----SQPRCIMH--EGNPPITKF 366 IV + ++ +AH LGHN GMNHD + C C + CIM+ G P F Sbjct: 333 IVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVF 392 Query: 367 SNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC 424 S+CS D E ++E+ CL ++ F ++CGN VEEGEECDCG + C C Sbjct: 393 SSCSRKDL-ETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCC 451 Query: 425 CLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDG 484 + CTL + CA GLCC+DC+ P+G CR N CDLPE+C G S CP + Y+ DG Sbjct: 452 NATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDG 511 Query: 485 IPCKE-RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCG-IKNATYI 542 C++ GYCY C +QC ++G GA A C++ +N+ GD G+CG + +++ Sbjct: 512 HSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFA 571 Query: 543 KCNISDVQCGRIQCENVTEIP-----NMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597 KC + D +CG+IQC+ P +S T + + I+C T +LG PD G Sbjct: 572 KCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGL 631 Query: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657 V GT+C IC++R C +I++ + C+ RG+CNN+ +CHC W PP C G Sbjct: 632 VLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFG 691 Query: 658 YGGSVDSGP 666 +GGS DSGP Sbjct: 692 FGGSTDSGP 700 >gi|148664238 a disintegrin and metalloprotease domain 32 [Homo sapiens] Length = 787 Score = 337 bits (864), Expect = 3e-92 Identities = 224/755 (29%), Positives = 380/755 (50%), Gaps = 47/755 (6%) Query: 33 VVIPVRITGTTRGMTPPGW--LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAIL 90 +VIP +I T + + +SYI+P + + +H+K + L + ++ Y +QG++ Sbjct: 28 IVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLYTVHLKQRYFLADNFM-IYLY-NQGSMN 85 Query: 91 EDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVY 150 +Q CYY G +EG P+S+V+LSTC G +GILQ + +Y I+PL + F+H++Y Sbjct: 86 TYSSDIQTQCYYQGNIEGYPDSMVTLSTC-SGLRGILQFENVSYGIEPLESAVEFQHVLY 144 Query: 151 KMDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYL 210 K+ +E+ + F+ + + + I S + + + + + +E+ +V+D L Sbjct: 145 KLKNEDNDIAI----FIDRSLKEQPMDDNIFISEKSEPAVPDLFPLY--LEMHIVVDKTL 198 Query: 211 YIRYERNDSKLLEDLYV-IVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHL 268 Y Y +DS ++ + + IV + +S+ V ++L LE+W+++N I V + + + Sbjct: 199 Y-DYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQK 257 Query: 269 YCKWKSENITPRMQHDTSHLFTTLGLRGLSGIGAFRGMCTPHRSCAIVTFMNK-TLGTFS 327 + +WK + R HD ++L + G MC S + + + TL F+ Sbjct: 258 FLEWKQSYLNLR-PHDIAYLLIYMDYPRYLGAVFPGTMCITRYSAGVALYPKEITLEAFA 316 Query: 328 IAVAHHLGHNLGMNHDEDT-CRCSQPRCIMHEGNPPITK------FSNCSYGDFWEYTVE 380 + V L +LG+++D+ C+CS+ CIM NP + + FS+CS F + Sbjct: 317 VIVTQMLALSLGISYDDPKKCQCSESTCIM---NPEVVQSNGVKTFSSCSLRSFQNFISN 373 Query: 381 -RTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCC-LSNCTLTDGSTCA 438 KCL + CGNG +E E CDCG C CC C L DG+ C Sbjct: 374 VGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCY 433 Query: 439 FGLCCKDCKFLPSGKVCRKEVN-ECDLPEWCNGTSHKCPDDFYVEDGIPCKERGY-CYEK 496 GLCCKDC+ L SG CR + + ECD+ E CNG+S +C D + +G+ CK + CY+ Sbjct: 434 KGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFICYDG 493 Query: 497 SCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGI-KNATYIKCNISDVQCGRIQ 555 CHD + +C +FG G+ A CY+E+ + DR G+CG +N Y+ C ++ CGR+ Sbjct: 494 DCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLV 553 Query: 556 CENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHC 615 C T P ++ V +A D +C + DY L PD VK+G++C I +C++R C Sbjct: 554 CTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNREC 613 Query: 616 VHITILNSN---CSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSV----DSGPPP 668 V I+ ++ CS C+ G+C++++ CHC+ + PPNC I+ G S+ D G Sbjct: 614 VESRIIKASAHVCSQQ-CSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIM 672 Query: 669 KRKK-KKKFCYLCILLLIVLFILLCCLYRLCKK--SKPIKKQQDVQTPSAKEEEKIQRRP 725 +R K + +L L+ + +++ L +K K K+++ + +K E Q Sbjct: 673 ERASGKTENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYA 732 Query: 726 HELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQ 760 + + SQ T S+S Q S+S+ Sbjct: 733 SQSSSEGSTQTYASQ-----TRSESSSQADTSKSK 762 >gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapiens] Length = 735 Score = 335 bits (860), Expect = 8e-92 Identities = 204/708 (28%), Positives = 363/708 (51%), Gaps = 55/708 (7%) Query: 53 SYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILE-DQPFVQNNCYYHGYVEGDPE 111 SY + G+ + +++ K L + V++Y+ G + DQ F QN C+Y GY+EG P+ Sbjct: 46 SYKIVIEGKPYTVNLMQKNFL-PHNFRVYSYSGTGIMKPLDQDF-QNFCHYQGYIEGYPK 103 Query: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQN-E 170 S+V +STC G +G+LQ + +Y I+PL S FEH++Y++ ++ S +++ + Sbjct: 104 SVVMVSTCTG-LRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRD 162 Query: 171 ITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVN 230 ++ +++ S + Q + + +E+ V+++ LY + + + + ++ ++ Sbjct: 163 LSFKLQ------SVEPQQDFA------KYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIG 210 Query: 231 IVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRMQHDTSHLF 289 + ++I + ++L LE+W ++N I + + +H + +WK+ + R HD + L Sbjct: 211 LTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLR-PHDVAFLL 269 Query: 290 TTLGLRGLSGIGAFRG-MCTPHRSCAIVTFMNK-TLGTFSIAVAHHLGHNLGMNHDE-DT 346 G F+G MC + + +V +L + ++ +A L ++G+ +D+ + Sbjct: 270 VYREKSNYVG-ATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINK 328 Query: 347 CRCSQPRCIMHEGNPP------ITKFSNCSYGDFWEY-TVERTKCLLETVHTKDIFNVKR 399 C+CS CIM NP + FSNCS+ DF + + ++++CL F + Sbjct: 329 CQCSGAVCIM---NPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQA 385 Query: 400 -CGNGVVEEGEECDCGPLKHCAK--DPCC-LSNCTLTDGSTCAFGLCCKDCKFLPSGKVC 455 CGN +E GEECDCG + CA + CC ++ C GS CA G CC++C F+ ++C Sbjct: 386 VCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMC 445 Query: 456 RKEVNECDLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGAN 514 R ECDLPE+CNG+S CP++ YV+ G PC + C + C ++QC FG Sbjct: 446 RPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVE 505 Query: 515 TASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWA 574 CY LN+ D G+CGI ++ Y +C ++QCG++ C+ V + T+ +A Sbjct: 506 FGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYA 565 Query: 575 RFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRG 634 + +C + ++ +KDGT CG + +C ++ CV + L +C+ CN RG Sbjct: 566 NISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRG 625 Query: 635 ICNNKHHCHCNYLWDPPNCLIKG---YGGSVDSG--PP---PKRKKKKKFCYLC------ 680 +CNNK HCHC+ + PP+C ++ GGS+DSG PP P R ++++ Sbjct: 626 VCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPM 685 Query: 681 ---ILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEKIQRRP 725 L I FI+ C L + K +K+ + S+ E+ + + P Sbjct: 686 RWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEP 733 >gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo sapiens] Length = 754 Score = 314 bits (805), Expect = 2e-85 Identities = 198/669 (29%), Positives = 327/669 (48%), Gaps = 40/669 (5%) Query: 52 LSYILPFGGQKHIIHI-KVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDP 110 L Y + + ++H+ + ++ L S + F Y+ +G P + ++C+Y G + + Sbjct: 59 LLYEIKLNRKTLVLHLLRSREFLGSNYSETF-YSMKGEAFTRHPQIMDHCFYQGSIVHEY 117 Query: 111 ESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNE 170 +S S+STC G +G +IND Y I+P+ +S EHLV+K + + + E Sbjct: 118 DSAASISTC-NGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPY----GANYSCTE 172 Query: 171 ITCRMEFEEIDNSTQKQSSYVGWWIHF-RIVEIVVVIDNYLYIRYERNDSKLLEDLYVIV 229 + + DN +++ S G IH + VE+ +V D+ +Y R +KL ++ +V Sbjct: 173 LNFTRKTVPGDNESEEDSKIKG--IHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMV 230 Query: 230 NIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHL 288 N V+ I + + V L G+EIWT+++ I + ++ ++ + W+ + + R D L Sbjct: 231 NFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVL 290 Query: 289 FTTLGLRG-LSGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTC 347 + L + GI GMC P+ S +I+ + + +AH LGHNLGM HDE C Sbjct: 291 LSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPC 350 Query: 348 RCSQPRCIMH-EGNPPITKFSNCSYGDFWEYTVE-RTKCLLETVHTKDIFNVKRCGNGVV 405 C +C+M +G+ P KFS CS + +Y + + C+L + + + CGN + Sbjct: 351 TCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKL 410 Query: 406 EEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLP 465 +EGEECDCGP + C C C L G TCA G CC+ C+ +G +CR +ECD P Sbjct: 411 DEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFP 470 Query: 466 EWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKEL 524 E C G S CP D + +G PCK GYC+ C R +QC +F A + + CYK + Sbjct: 471 EMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICYK-M 529 Query: 525 NTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHW--ARFNDIMCW 582 NT G++ G+C K ++ C DV+CG+I C + + T H + N + Sbjct: 530 NTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKC 589 Query: 583 STDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHI--TILNSNCSPAFCNKRGICNNKH 640 T + L DIG V GT+CG +C + C+++ +++NC P+ CN+ + + Sbjct: 590 KTIF-LYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNC-PSQCNENPVDGHGL 647 Query: 641 HCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVL----FILLCCLYR 696 CHC P C + L ++L++V+ ++L YR Sbjct: 648 QCHCEEGQAPVAC--------------EETLHVTNITILVVVLVLVIVGIGVLILLVRYR 693 Query: 697 LCKKSKPIK 705 C K K ++ Sbjct: 694 KCIKLKQVQ 702 >gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein [Homo sapiens] Length = 775 Score = 309 bits (792), Expect = 6e-84 Identities = 207/755 (27%), Positives = 343/755 (45%), Gaps = 65/755 (8%) Query: 52 LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPE 111 L Y + G+ ++++K K L + Y G + P + ++CYY G++ + Sbjct: 57 LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKV 116 Query: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLA--FSTTFEHLVYKMDSEEKQFSTMRSGFMQN 169 S S+STC G +G D Y I+PL+ EH ++K + +EK + + Sbjct: 117 SDASISTC-RGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDS-------- 167 Query: 170 EITCRMEFEEIDNSTQKQSSYVGWWI----------HFRIVEIVVVIDNYLYIRYERNDS 219 TC M+ + Q+ + + H + +E +V+DN + RY N Sbjct: 168 --TCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQD 225 Query: 220 KLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENIT 278 ++ + ++ + N V+ + + V L G+EIWT+K+ I + + ++ + KW+ ++ Sbjct: 226 EIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLS 285 Query: 279 PRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHN 337 R +HD + L T L G + G+ MC+P+ S +V + L + +AH +GHN Sbjct: 286 RRKRHDIAQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGTMAHEMGHN 344 Query: 338 LGMNHDEDTCRCSQPRCIMHEGNPPI--TKFSNCS---YGDFWEYTVERTKCLLETVHTK 392 GM HD+ +C+C C+M + T FS+CS Y F+E + + CL Sbjct: 345 FGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKL--SNCLFNAPLPT 402 Query: 393 DIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSG 452 DI + CGN +VE GE+CDCG + C C C + CA G CC+ C+F +G Sbjct: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAG 462 Query: 453 KVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSCHDRNEQCRRIFGA 511 VCR +ECDLPE CNG S CPDD + +G PC +G+C +C EQC ++G Sbjct: 463 MVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGP 522 Query: 512 GANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTV 571 G A ++CY N G + G+C + T I C +D CG++ C+ SD+ Sbjct: 523 GTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQ------GGSDNLPW 575 Query: 572 HWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHI--TILNSNCSPAF 629 + C + D +IG V +GT+CG + +CI+ CV I ++NCS + Sbjct: 576 KGRIVTFLTCKTFDPE--DTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCS-SK 632 Query: 630 CNKRGICNNKHHCHCNYLWDPPNCLIKG--YGGSVDSGPPPKRKKKKKFCYLCILLLIVL 687 C +C+++ C C W PP+C + S+ G + + V+ Sbjct: 633 CKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVG--------------VLFPMAVI 678 Query: 688 FILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEKIQRRPH---ELPPQSQPWVMPSQSQPP 744 F+++ + R + KK Q + + K +R+P + PQ + P P Sbjct: 679 FVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVKAVQPQEMSQMKPHVYDLP 738 Query: 745 VTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQP 779 V ++ + P T + P P S P Sbjct: 739 VEGNEPPASFHKDTNALPPTVFKDNPVSTPKDSNP 773 >gi|18252045 ADAM metallopeptidase domain 33 isoform alpha preproprotein [Homo sapiens] Length = 813 Score = 306 bits (784), Expect = 5e-83 Identities = 234/825 (28%), Positives = 375/825 (45%), Gaps = 78/825 (9%) Query: 3 MLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVI---PVRITGTTRGMTPPGWLSYILPFG 59 +LLLL L + +G +Q P P V+ P R ++ P L Sbjct: 14 LLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAE 73 Query: 60 GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119 GQ+ ++ ++ L + Y G + P ++C+Y G V G P+S V L TC Sbjct: 74 GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133 Query: 120 FGGFQGILQIN-DFAYEIKPLA------FSTTFEHLVYKMDSEEKQFSTMRSGFMQNEIT 172 G G++ ++ + +Y ++P FST H +++M+ Q T + + Sbjct: 134 -SGMSGLITLSRNASYYLRPWPPRGSKDFST---HEIFRME----QLLTWKGTCGHRDPG 185 Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIV 232 + + Q + + +E+ +V D+ L++ RN + + L + N V Sbjct: 186 NKAGMTSLPGGPQSRGRREARRTR-KYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244 Query: 233 DSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291 D +L + ++V L GLE+WT ++ V D ++ + +W+ + + HD++ L T Sbjct: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWR-RGLWAQRPHDSAQLLTG 303 Query: 292 LGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTC--- 347 +G + G+ GMC S + T ++ + +AH +GH+LG++HD D C Sbjct: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVE 363 Query: 348 -RCSQPRCIMHE--GNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDI-FNVKRCGNG 403 C+M G+P FS CS + + L + CGNG Sbjct: 364 AAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNG 423 Query: 404 VVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNEC 462 VE GEECDCGP + C +D CC + NC+L G+ CA G CC C P+G +CR+ + +C Sbjct: 424 FVEAGEECDCGPGQEC-RDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDC 482 Query: 463 DLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGANTASETCY 521 DLPE+C GTS CP D Y+ DG PC + GYC++ +C +QC++++G G++ A E C+ Sbjct: 483 DLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACF 542 Query: 522 KELNTLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTE---IPNMSD-HTTVHWARF 576 + +N+ GD G+CG ++ C D CG++QC+ P+M +TVH Sbjct: 543 QVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH-LDG 601 Query: 577 NDIMCWST----DYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNK 632 ++ C L + G +G V+ GT+CG +C R C C+ Sbjct: 602 QEVTCRGALALPSAQLDLLG--LGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHS 659 Query: 633 RGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILL- 691 G+CN+ H+CHC W PP C G+GGS+DSGP + + +L +LL VL LL Sbjct: 660 HGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPV---QAENHDTFLLAMLLSVLLPLLP 716 Query: 692 -----CCLYRL-----------CKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQS--Q 733 C YRL C++ +D ++ P EL P + Q Sbjct: 717 GAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKD---GPHRDHPLGGVHPMELGPTATGQ 773 Query: 734 PWVMPSQSQPPVTPSQSH-PQVMPSQSQPPVTPSQSQPRVMPSQS 777 PW P+ P SH P P + P V+P +V +S Sbjct: 774 PW--------PLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRS 810 >gi|7656861 a disintegrin and metalloprotease domain 18 preproprotein [Homo sapiens] Length = 739 Score = 306 bits (784), Expect = 5e-83 Identities = 198/634 (31%), Positives = 308/634 (48%), Gaps = 35/634 (5%) Query: 54 YILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESL 113 YI+ GQ + +H+ + L L V+TY + G++ P+ +C+Y GY P S Sbjct: 47 YIITIDGQPYTLHLGKQSFLPQNFL-VYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSF 105 Query: 114 VSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMR---SGFMQNE 170 V+LS C G +G LQ + +Y I+P+ S FEH++Y+M + + S + S Q + Sbjct: 106 VTLSIC-SGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKD 164 Query: 171 ITCRMEFE-EIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIV 229 ++ +I N ++ Y+ EI ++++ LY + + + ++ Sbjct: 165 QPYKVPLNSQIKNLSKLLPQYL---------EIYIIVEKALYDYMGSEMMAVTQKIVQVI 215 Query: 230 NIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRMQHDTSHL 288 +V+++ + V+L LE+W+N+N I D + + WK + + R HD ++L Sbjct: 216 GLVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILR-PHDIAYL 274 Query: 289 FTTLGLRGLSGIGAFRGMCTPHRSCAIVTFMNKT-LGTFSIAVAHHLGHNLGMNHDEDT- 346 G +C I + + L FS+ +A LG N+G+ +D+ T Sbjct: 275 LVYRKHPKYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQ 334 Query: 347 CRCSQPRCIM-HEGNPPITK--FSNCSYGDFWEYTVER--TKCLLETVHTKDIF-NVKRC 400 C C + CIM HE + FSNCS D+ Y V + TKCL + + + + N C Sbjct: 335 CFCLRATCIMNHEAVSASGRKIFSNCSMHDY-RYFVSKFETKCLQKLSNLQPLHQNQPVC 393 Query: 401 GNGVVEEGEECDCGPLKHCAKDPCCLSN-CTLTDGSTCAFGLCCKD-CKFLPSGKVCRKE 458 GNG++E EECDCG C CC N C L C G CC C+ +G CRK Sbjct: 394 GNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKS 453 Query: 459 VN-ECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTA 516 ++ ECD E+CNGTS C D Y +G CK YCY C + QC +IFG GA A Sbjct: 454 IDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGA 513 Query: 517 SETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARF 576 C+KE+N+L +R +CG KN+ + C DV CG++ C + N SD + ++ Sbjct: 514 PFACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYI 573 Query: 577 NDIMCWS--TDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAF-CNKR 633 D +C S T + G D V DGT CG + C+++ C + ++ NC+ C + Sbjct: 574 QDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGK 633 Query: 634 GICNNKHHCHCNYLWDPPNCLIK--GYGGSVDSG 665 GICNN +C C PP+C + GGS+D G Sbjct: 634 GICNNFGNCQCFPGHRPPDCKFQFGSPGGSIDDG 667 >gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens] Length = 856 Score = 291 bits (744), Expect = 2e-78 Identities = 229/802 (28%), Positives = 359/802 (44%), Gaps = 96/802 (11%) Query: 32 DVVIPVRITGT-TRGMTP------PGWLSYILPFGGQKHIIHI-KVKKLLFSKHLPVFTY 83 +VV+P R+ G R P P +SY+L G +H+ K + LL S + +T Sbjct: 30 EVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTA 89 Query: 84 TDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPL-AFS 142 + G+ + +QP Q++C+Y G+VEG P+S SLSTC G +G Q+ + I+PL Sbjct: 90 AN-GSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTC-AGLRGFFQVGSDLHLIEPLDEGG 147 Query: 143 TTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYV-----GWWI-- 195 H VY+ + +Q TC + + + + +++ V G + Sbjct: 148 EGGRHAVYQAEH-----------LLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPS 196 Query: 196 -HFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNK 254 R VE+ VV+DN + + +++ + + +VN VD + + +V+L GLEIW ++ Sbjct: 197 RETRYVELYVVVDNAEF-QMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQ 255 Query: 255 NLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRS 312 + V D ++ W++ T R HD L T + G + G MC+ H S Sbjct: 256 DRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCS-HSS 314 Query: 313 CAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDT--CRCSQ----PRCIM--HEGNPPIT 364 A+ +K + +AH +GHNLGM+HDE+ CRC + RCIM G+ Sbjct: 315 GAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPR 374 Query: 365 KFSNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKD 422 FS+CS + E +ER + CL + CGN VE GE+CDCGP + C Sbjct: 375 MFSDCSQA-YLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNR 433 Query: 423 PCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVE 482 C + C L +G+ CA G CC++CK P+G++CR + + CDL E+C+G +CP+D + E Sbjct: 434 CCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQE 493 Query: 483 DGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYI 542 +G PC GYCY +C +QC+ +G G A E+C+ G + + Sbjct: 494 NGTPC-SGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVL 552 Query: 543 KCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGT 602 +C GR C I ++ T G V +GT Sbjct: 553 QCKGGQQPLGRAIC-----IVDVCHALTTE------------------DGTAYEPVPEGT 589 Query: 603 ECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSV 662 CG + +C C + + S+ A C+ G+CN+K CHC+ W PP+C Sbjct: 590 RCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHA 649 Query: 663 DSGPPPKRKKKKKFCYLCILLLIVLFILLC--CLYRLCK---------------KSKPIK 705 SG P F + ++LL V+ + L +YR + +S P+ Sbjct: 650 ASGSLP------VFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLF 703 Query: 706 KQQDVQTPSAKEEEKIQRRPHELPPQS---QPWVMPSQSQPPVTPSQSHPQVMPSQSQP- 761 Q + P+ R P EL P + QP P+ S P + P + S P Sbjct: 704 HQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPV 763 Query: 762 PVTPSQSQPRVMPSQSQPPVMP 783 PV Q+ +V+ PPV P Sbjct: 764 PVYTRQAPKQVIKPTFAPPVPP 785 >gi|24041040 ADAM metallopeptidase domain 33 isoform beta preproprotein [Homo sapiens] Length = 787 Score = 288 bits (737), Expect = 1e-77 Identities = 230/825 (27%), Positives = 369/825 (44%), Gaps = 104/825 (12%) Query: 3 MLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVI---PVRITGTTRGMTPPGWLSYILPFG 59 +LLLL L + +G +Q P P V+ P R ++ P L Sbjct: 14 LLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAE 73 Query: 60 GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119 GQ+ ++ ++ L + Y G + P ++C+Y G V G P+S V L TC Sbjct: 74 GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133 Query: 120 FGGFQGILQIN-DFAYEIKPLA------FSTTFEHLVYKMDSEEKQFSTMRSGFMQNEIT 172 G G++ ++ + +Y ++P FST H +++M+ Q T + + Sbjct: 134 -SGMSGLITLSRNASYYLRPWPPRGSKDFST---HEIFRME----QLLTWKGTCGHRDPG 185 Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIV 232 + + Q + + +E+ +V D+ L++ RN + + L + N V Sbjct: 186 NKAGMTSLPGGPQSRGRREARRTR-KYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244 Query: 233 DSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291 D +L + ++V L GLE+WT ++ V D ++ + +W+ + + HD++ L T Sbjct: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWR-RGLWAQRPHDSAQLLTG 303 Query: 292 LGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTC--- 347 +G + G+ GMC S + T ++ + +AH +GH+LG++HD D C Sbjct: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVE 363 Query: 348 -RCSQPRCIMHE--GNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDI-FNVKRCGNG 403 C+M G+P FS CS + + L + CGNG Sbjct: 364 AAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNG 423 Query: 404 VVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNEC 462 VE GEECDCGP + C +D CC + NC+L G+ CA G CC C P+G +CR+ + +C Sbjct: 424 FVEAGEECDCGPGQEC-RDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDC 482 Query: 463 DLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGANTASETCY 521 DLPE+C GTS CP D Y+ DG PC + GYC++ +C +QC++++G G++ A E C+ Sbjct: 483 DLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACF 542 Query: 522 KELNTLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTE---IPNMSD-HTTVHWARF 576 + +N+ GD G+CG ++ C D CG++QC+ P+M +TVH Sbjct: 543 QVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH-LDG 601 Query: 577 NDIMCWST----DYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNK 632 ++ C L + G +G V+ GT+CG Sbjct: 602 QEVTCRGALALPSAQLDLLG--LGLVEPGTQCG--------------------------P 633 Query: 633 RGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILL- 691 R +CN+ H+CHC W PP C G+GGS+DSGP + + +L +LL VL LL Sbjct: 634 RMVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPV---QAENHDTFLLAMLLSVLLPLLP 690 Query: 692 -----CCLYRL-----------CKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQS--Q 733 C YRL C++ +D ++ P EL P + Q Sbjct: 691 GAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKD---GPHRDHPLGGVHPMELGPTATGQ 747 Query: 734 PWVMPSQSQPPVTPSQSH-PQVMPSQSQPPVTPSQSQPRVMPSQS 777 PW P+ P SH P P + P V+P +V +S Sbjct: 748 PW--------PLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRS 784 >gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6 preproprotein [Homo sapiens] Length = 863 Score = 275 bits (702), Expect = 2e-73 Identities = 219/816 (26%), Positives = 349/816 (42%), Gaps = 89/816 (10%) Query: 56 LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115 L G HI+ + + L + Y G + + NC Y G V G S VS Sbjct: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132 Query: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172 + TC G ++ L T + + Q + S + T Sbjct: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178 Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222 C + + E + TQK + H R VE+V+V D+ +Y R+ LL Sbjct: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236 Query: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281 + ++D+ + V+V L GLE WT ++L+ + + ++ + W+ ++ PR+ Sbjct: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296 Query: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340 HD++ L T G + G+ +C+P S + + ++ + ++AH LGH+LG+ Sbjct: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356 Query: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391 +HD ++C C P CIM P FSNCS + ++ CL E + + Sbjct: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416 Query: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449 CGN VE GE+CDCG L C DPCC S C L G+ CA G CC++C+ Sbjct: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474 Query: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508 PSG CR +CDLPE+C G S +CP D + DG PC + C C +QC+ + Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534 Query: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567 +G GA A+ C + NT G+ G CG + +Y+ C D CG++QC+ P + Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594 Query: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619 + W + ++ C W HL + G D+ + GT CG +CI C + Sbjct: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650 Query: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679 +L + + C+ G+C++ HC+C W PP+C + K L Sbjct: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699 Query: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQT-----PSAKEEEKIQRRPH 726 LL++++ ++L Y RLC+ P + + Q+ P + + R Sbjct: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759 Query: 727 ELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQ------PP 780 + S P PS+ PP S+ + + PP P + P V +SQ PP Sbjct: 760 QASALSFP-APPSRPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPP 818 Query: 781 VMPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPP 816 P + PQ P + P ++PS+ PP Sbjct: 819 RKPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 854 >gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5 preproprotein [Homo sapiens] Length = 862 Score = 273 bits (699), Expect = 4e-73 Identities = 220/815 (26%), Positives = 350/815 (42%), Gaps = 88/815 (10%) Query: 56 LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115 L G HI+ + + L + Y G + + NC Y G V G S VS Sbjct: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132 Query: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172 + TC G ++ L T + + Q + S + T Sbjct: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178 Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222 C + + E + TQK + H R VE+V+V D+ +Y R+ LL Sbjct: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236 Query: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281 + ++D+ + V+V L GLE WT ++L+ + + ++ + W+ ++ PR+ Sbjct: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296 Query: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340 HD++ L T G + G+ +C+P S + + ++ + ++AH LGH+LG+ Sbjct: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356 Query: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391 +HD ++C C P CIM P FSNCS + ++ CL E + + Sbjct: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416 Query: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449 CGN VE GE+CDCG L C DPCC S C L G+ CA G CC++C+ Sbjct: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474 Query: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508 PSG CR +CDLPE+C G S +CP D + DG PC + C C +QC+ + Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534 Query: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567 +G GA A+ C + NT G+ G CG + +Y+ C D CG++QC+ P + Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594 Query: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619 + W + ++ C W HL + G D+ + GT CG +CI C + Sbjct: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650 Query: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679 +L + + C+ G+C++ HC+C W PP+C + K L Sbjct: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699 Query: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQTPSAKEEEKIQR----RPHE 727 LL++++ ++L Y RLC+ P + + Q+ ++ QR R + Sbjct: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759 Query: 728 LPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQ------PPV 781 S P PS+ PP S+ + + PP P + P V +SQ PP Sbjct: 760 ASALSFP-APPSRPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPR 818 Query: 782 MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPP 816 P + PQ P + P ++PS+ PP Sbjct: 819 KPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 853 >gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4 preproprotein [Homo sapiens] Length = 838 Score = 271 bits (692), Expect = 2e-72 Identities = 215/805 (26%), Positives = 343/805 (42%), Gaps = 92/805 (11%) Query: 56 LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115 L G HI+ + + L + Y G + + NC Y G V G S VS Sbjct: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132 Query: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172 + TC G ++ L T + + Q + S + T Sbjct: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178 Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222 C + + E + TQK + H R VE+V+V D+ +Y R+ LL Sbjct: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236 Query: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281 + ++D+ + V+V L GLE WT ++L+ + + ++ + W+ ++ PR+ Sbjct: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296 Query: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340 HD++ L T G + G+ +C+P S + + ++ + ++AH LGH+LG+ Sbjct: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356 Query: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391 +HD ++C C P CIM P FSNCS + ++ CL E + + Sbjct: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416 Query: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449 CGN VE GE+CDCG L C DPCC S C L G+ CA G CC++C+ Sbjct: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474 Query: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508 PSG CR +CDLPE+C G S +CP D + DG PC + C C +QC+ + Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534 Query: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567 +G GA A+ C + NT G+ G CG + +Y+ C D CG++QC+ P + Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594 Query: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619 + W + ++ C W HL + G D+ + GT CG +CI C + Sbjct: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650 Query: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679 +L + + C+ G+C++ HC+C W PP+C + K L Sbjct: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699 Query: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQ 731 LL++++ ++L Y RLC+ P + + Q+ ++ QR L + Sbjct: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQR---ALLAR 756 Query: 732 SQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPPVMPSQSHPQLT 791 + + PP P + P V +SQ P P PP P + PQ Sbjct: 757 GTKAELADRPNPPTRPLPADPVVRSPKSQGPAKP------------PPPRKPLPADPQGR 804 Query: 792 PSQSQPPVTPSQRQPQLMPSQSQPP 816 P + P ++PS+ PP Sbjct: 805 CPSGDLPGPGAGIPPLVVPSRPAPP 829 >gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3 preproprotein [Homo sapiens] Length = 839 Score = 268 bits (686), Expect = 1e-71 Identities = 212/792 (26%), Positives = 340/792 (42%), Gaps = 83/792 (10%) Query: 56 LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115 L G HI+ + + L + Y G + + NC Y G V G S VS Sbjct: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132 Query: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172 + TC G ++ L T + + Q + S + T Sbjct: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178 Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222 C + + E + TQK + H R VE+V+V D+ +Y R+ LL Sbjct: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236 Query: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281 + ++D+ + V+V L GLE WT ++L+ + + ++ + W+ ++ PR+ Sbjct: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296 Query: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340 HD++ L T G + G+ +C+P S + + ++ + ++AH LGH+LG+ Sbjct: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356 Query: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391 +HD ++C C P CIM P FSNCS + ++ CL E + + Sbjct: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416 Query: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449 CGN VE GE+CDCG L C DPCC S C L G+ CA G CC++C+ Sbjct: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474 Query: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508 PSG CR +CDLPE+C G S +CP D + DG PC + C C +QC+ + Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534 Query: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567 +G GA A+ C + NT G+ G CG + +Y+ C D CG++QC+ P + Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594 Query: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619 + W + ++ C W HL + G D+ + GT CG +CI C + Sbjct: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650 Query: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679 +L + + C+ G+C++ HC+C W PP+C + K L Sbjct: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699 Query: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQT-----PSAKEEEKIQRRPH 726 LL++++ ++L Y RLC+ P + + Q+ P + + R Sbjct: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759 Query: 727 ELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPPVMPSQS 786 + S P PS+ PP S+ P++ PP P + P+ P + Sbjct: 760 QASALSFP-APPSRPLPPDPVSKRLQSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAGI 818 Query: 787 HPQLTPSQSQPP 798 P + PS+ PP Sbjct: 819 PPLVVPSRPAPP 830 >gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2 preproprotein [Homo sapiens] Length = 814 Score = 268 bits (685), Expect = 2e-71 Identities = 209/769 (27%), Positives = 334/769 (43%), Gaps = 80/769 (10%) Query: 56 LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115 L G HI+ + + L + Y G + + NC Y G V G S VS Sbjct: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132 Query: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172 + TC G ++ L T + + Q + S + T Sbjct: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178 Query: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222 C + + E + TQK + H R VE+V+V D+ +Y R+ LL Sbjct: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236 Query: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281 + ++D+ + V+V L GLE WT ++L+ + + ++ + W+ ++ PR+ Sbjct: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296 Query: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340 HD++ L T G + G+ +C+P S + + ++ + ++AH LGH+LG+ Sbjct: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356 Query: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391 +HD ++C C P CIM P FSNCS + ++ CL E + + Sbjct: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416 Query: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449 CGN VE GE+CDCG L C DPCC S C L G+ CA G CC++C+ Sbjct: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474 Query: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508 PSG CR +CDLPE+C G S +CP D + DG PC + C C +QC+ + Sbjct: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534 Query: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567 +G GA A+ C + NT G+ G CG + +Y+ C D CG++QC+ P + Sbjct: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594 Query: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619 + W + ++ C W HL + G D+ + GT CG +CI C + Sbjct: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650 Query: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679 +L + + C+ G+C++ HC+C W PP+C + K L Sbjct: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699 Query: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQ 731 LL++++ ++L Y RLC+ P + + Q+ ++ QR + Sbjct: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759 Query: 732 SQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQPP 780 SQ P++ PP P + PQ P + P V+PS+ PP Sbjct: 760 SQG---PAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 805 >gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo sapiens] Length = 832 Score = 260 bits (664), Expect = 4e-69 Identities = 180/606 (29%), Positives = 291/606 (48%), Gaps = 44/606 (7%) Query: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAF-----STTFEHLVYK-- 151 +CYYHG + G +S V+LSTC G G+ + + F Y I+PL ST H++ K Sbjct: 195 HCYYHGSIRGVKDSKVALSTC-NGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTL 253 Query: 152 --MDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNY 209 S++ + TM G ++ E + + + + G + + +E+++V D+ Sbjct: 254 AGQYSKQMKNLTMERG---DQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHK 310 Query: 210 LYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVH 267 Y ++ + + +VN+VDSI + + +V+L +E WT K+ I + + + +H Sbjct: 311 TYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLH 370 Query: 268 LYCKWKSENITPRMQHDTSHLFTTLGLR-GLSGIGAFRGMCTPHRSCAIVTF--MNKTLG 324 + K++ + D HL + + S + F G+C+ R + + Sbjct: 371 EFSKYRQRI---KQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQ 427 Query: 325 TFSIAVAHHLGHNLGMNHDEDTCRCSQP--RCIMHE-GNPPITKFSNCSYGDFWEYTVER 381 S ++A +LG + + C C++ CIM E G KFS CS ++ ++ Sbjct: 428 VLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRG 487 Query: 382 TKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGL 441 L TK +F CGNG VE GEECDCG C C C+L++G+ C+ G Sbjct: 488 GGACLFNRPTK-LFEPTECGNGYVEAGEECDCGFHVECYG--LCCKKCSLSNGAHCSDGP 544 Query: 442 CCKD--CKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSC 498 CC + C F P G CR VNECD+ E+C G S +CP + + +DG C + +G CY C Sbjct: 545 CCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGEC 604 Query: 499 HDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCEN 558 R+ QC+ I+G A + + CY++LNT G G+CG +I+C+ DV CG + C N Sbjct: 605 KTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTN 664 Query: 559 VTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHR 613 +T P + T + + I C L D+G V+DGT CG +C+ R Sbjct: 665 LTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLD-DDTDVGYVEDGTPCGPSMMCLDR 723 Query: 614 HCVHITILNSNCSP-----AFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPP 668 C+ I LN + P C+ G+C+N+ C C++ W +C I+ V + PP Sbjct: 724 KCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIR---DPVRNLHPP 780 Query: 669 KRKKKK 674 K + K Sbjct: 781 KDEGPK 786 >gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein [Homo sapiens] Length = 906 Score = 258 bits (660), Expect = 1e-68 Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%) Query: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154 +CYY G++ G+P+S V+LSTC G G+ + Y I+P TT E H VYK Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192 Query: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202 E + S F Q IT + + + ++++ Y+ E+ Sbjct: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243 Query: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260 ++V D+ ++ ++ + +VN+ D I D + +++L +E W N + + Sbjct: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303 Query: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319 + ++ + K++ + I + + D HLF+ SG G+C+ + + F Sbjct: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361 Query: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371 L ++ +A L HN+G+ D+ C+C CIM + G KF+ C+ Sbjct: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419 Query: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430 ++ ++ L +K + + CGNG +E GEECDCG C + C CT Sbjct: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478 Query: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489 LT S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C + + DG C Sbjct: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538 Query: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549 +G C+ C R+ QC+ I+G + + CY++LN G G+CG T+I+CN DV Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598 Query: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604 CG + C N+ IP + + +T+ + + C L + D+G V+DGT C Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657 Query: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653 G +C+ C+ + N S+ C+ G+C+N+ C CN W +C Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711 >gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein [Homo sapiens] Length = 899 Score = 258 bits (660), Expect = 1e-68 Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%) Query: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154 +CYY G++ G+P+S V+LSTC G G+ + Y I+P TT E H VYK Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192 Query: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202 E + S F Q IT + + + ++++ Y+ E+ Sbjct: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243 Query: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260 ++V D+ ++ ++ + +VN+ D I D + +++L +E W N + + Sbjct: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303 Query: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319 + ++ + K++ + I + + D HLF+ SG G+C+ + + F Sbjct: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361 Query: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371 L ++ +A L HN+G+ D+ C+C CIM + G KF+ C+ Sbjct: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419 Query: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430 ++ ++ L +K + + CGNG +E GEECDCG C + C CT Sbjct: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478 Query: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489 LT S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C + + DG C Sbjct: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538 Query: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549 +G C+ C R+ QC+ I+G + + CY++LN G G+CG T+I+CN DV Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598 Query: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604 CG + C N+ IP + + +T+ + + C L + D+G V+DGT C Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657 Query: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653 G +C+ C+ + N S+ C+ G+C+N+ C CN W +C Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711 >gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein [Homo sapiens] Length = 823 Score = 258 bits (660), Expect = 1e-68 Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%) Query: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154 +CYY G++ G+P+S V+LSTC G G+ + Y I+P TT E H VYK Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192 Query: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202 E + S F Q IT + + + ++++ Y+ E+ Sbjct: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243 Query: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260 ++V D+ ++ ++ + +VN+ D I D + +++L +E W N + + Sbjct: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303 Query: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319 + ++ + K++ + I + + D HLF+ SG G+C+ + + F Sbjct: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361 Query: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371 L ++ +A L HN+G+ D+ C+C CIM + G KF+ C+ Sbjct: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419 Query: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430 ++ ++ L +K + + CGNG +E GEECDCG C + C CT Sbjct: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478 Query: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489 LT S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C + + DG C Sbjct: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538 Query: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549 +G C+ C R+ QC+ I+G + + CY++LN G G+CG T+I+CN DV Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598 Query: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604 CG + C N+ IP + + +T+ + + C L + D+G V+DGT C Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657 Query: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653 G +C+ C+ + N S+ C+ G+C+N+ C CN W +C Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711 >gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein [Homo sapiens] Length = 870 Score = 258 bits (660), Expect = 1e-68 Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%) Query: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154 +CYY G++ G+P+S V+LSTC G G+ + Y I+P TT E H VYK Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192 Query: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202 E + S F Q IT + + + ++++ Y+ E+ Sbjct: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243 Query: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260 ++V D+ ++ ++ + +VN+ D I D + +++L +E W N + + Sbjct: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303 Query: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319 + ++ + K++ + I + + D HLF+ SG G+C+ + + F Sbjct: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361 Query: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371 L ++ +A L HN+G+ D+ C+C CIM + G KF+ C+ Sbjct: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419 Query: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430 ++ ++ L +K + + CGNG +E GEECDCG C + C CT Sbjct: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478 Query: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489 LT S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C + + DG C Sbjct: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538 Query: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549 +G C+ C R+ QC+ I+G + + CY++LN G G+CG T+I+CN DV Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598 Query: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604 CG + C N+ IP + + +T+ + + C L + D+G V+DGT C Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657 Query: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653 G +C+ C+ + N S+ C+ G+C+N+ C CN W +C Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711 >gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein [Homo sapiens] Length = 859 Score = 258 bits (660), Expect = 1e-68 Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%) Query: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154 +CYY G++ G+P+S V+LSTC G G+ + Y I+P TT E H VYK Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192 Query: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202 E + S F Q IT + + + ++++ Y+ E+ Sbjct: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243 Query: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260 ++V D+ ++ ++ + +VN+ D I D + +++L +E W N + + Sbjct: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303 Query: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319 + ++ + K++ + I + + D HLF+ SG G+C+ + + F Sbjct: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361 Query: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371 L ++ +A L HN+G+ D+ C+C CIM + G KF+ C+ Sbjct: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419 Query: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430 ++ ++ L +K + + CGNG +E GEECDCG C + C CT Sbjct: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478 Query: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489 LT S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C + + DG C Sbjct: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538 Query: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549 +G C+ C R+ QC+ I+G + + CY++LN G G+CG T+I+CN DV Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598 Query: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604 CG + C N+ IP + + +T+ + + C L + D+G V+DGT C Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657 Query: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653 G +C+ C+ + N S+ C+ G+C+N+ C CN W +C Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.322 0.138 0.456 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 38,400,739 Number of Sequences: 37866 Number of extensions: 2110461 Number of successful extensions: 19947 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 233 Number of HSP's successfully gapped in prelim test: 818 Number of HSP's that attempted gapping in prelim test: 10269 Number of HSP's gapped (non-prelim): 5796 length of query: 820 length of database: 18,247,518 effective HSP length: 111 effective length of query: 709 effective length of database: 14,044,392 effective search space: 9957473928 effective search space used: 9957473928 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.