Search of human proteins with 18491008

Search of human proteins with 18491008

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide
2 [Homo sapiens]
         (502 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...  1025   0.0  
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   401   e-112
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   395   e-110
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   390   e-108
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   384   e-106
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   382   e-106
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   376   e-104
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   375   e-104
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   370   e-102
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   363   e-100
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   363   e-100
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   361   e-99 
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   357   1e-98
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   353   2e-97
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   337   1e-92
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   330   2e-90
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   330   2e-90
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   316   3e-86
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   304   1e-82
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   246   3e-65
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   239   4e-63
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   231   1e-60
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   198   8e-51
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  197   2e-50
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   182   6e-46
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...   133   4e-31
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   131   2e-30
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   130   3e-30
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   129   5e-30
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   127   3e-29

>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score = 1025 bits (2649), Expect = 0.0
 Identities = 502/502 (100%), Positives = 502/502 (100%)

Query: 1   MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVD 60
           MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVD
Sbjct: 1   MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVD 60

Query: 61  FEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHI 120
           FEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHI
Sbjct: 61  FEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHI 120

Query: 121 FKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDP 180
           FKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDP
Sbjct: 121 FKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDP 180

Query: 181 HFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFL 240
           HFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFL
Sbjct: 181 HFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFL 240

Query: 241 PGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEEN 300
           PGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEEN
Sbjct: 241 PGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEEN 300

Query: 301 LICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMP 360
           LICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMP
Sbjct: 301 LICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMP 360

Query: 361 YTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDT 420
           YTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDT
Sbjct: 361 YTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDT 420

Query: 421 FNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLS 480
           FNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLS
Sbjct: 421 FNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLS 480

Query: 481 LKFRMGITISPVSHRLCAVPQV 502
           LKFRMGITISPVSHRLCAVPQV
Sbjct: 481 LKFRMGITISPVSHRLCAVPQV 502


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  401 bits (1031), Expect = e-112
 Identities = 214/495 (43%), Positives = 303/495 (61%), Gaps = 8/495 (1%)

Query: 12  LWAVVHPRTLLLGTVAFLLAA----DFLKRRRPKNYPPGPWRLPFLGNFFLV--DFEQSH 65
           LW        L G +  LL A      LK+RRP  +PPGP  LPF+GN + +    E  H
Sbjct: 4   LWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPH 63

Query: 66  LEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNG 125
           + ++   + YG +FSL+LG IS V++ G  ++KE L+H  + F +RP  P+   + K  G
Sbjct: 64  VYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGG 123

Query: 126 LIMSS-GQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKI 184
           L+ S  G+ W + RR  + + R FG G+KS E +I EE +   +AI+   G+PFD    I
Sbjct: 124 LLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLI 183

Query: 185 NNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPH 244
            NAVSNI   I FGERF Y+D+ FQ +++L  E   L AS +  LYN FPWI     G H
Sbjct: 184 TNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKH 243

Query: 245 QTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICS 304
           Q LF N   +  F+S +I+K   +  P   + F+DAYL EM +   +P+S+F +ENLI S
Sbjct: 244 QQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFS 303

Query: 305 TLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNA 364
             +L  AGTETT+  LRWA+L+MALYP IQ +VQ EID ++G   +PS   +  MPYT A
Sbjct: 304 VGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEA 363

Query: 365 VIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPD 424
           V+HEV R  NI+PL +    + D  + GY +PKGT ++TNL ++H D   W  P+ F+P+
Sbjct: 364 VLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPE 423

Query: 425 HFLE-NGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKF 483
            FL+ +G F K+EA +PFS+G+R CLGE LAR E+F+FFT+L+Q+F    P+     LK 
Sbjct: 424 RFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKP 483

Query: 484 RMGITISPVSHRLCA 498
           R+G+T+ P  + +CA
Sbjct: 484 RLGMTLQPQPYLICA 498


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  395 bits (1014), Expect = e-110
 Identities = 200/485 (41%), Positives = 301/485 (62%), Gaps = 8/485 (1%)

Query: 21  LLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFS 80
           LLL  V  LL    L  R     PPGP  L  LGN  L+  +     +    K+YG++++
Sbjct: 11  LLLALVCLLLT---LSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSMYT 67

Query: 81  LELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRF 140
           + LG    V+++G   +KEAL+   + F  R   P   +  K NG+  SSG  WK  R+F
Sbjct: 68  VHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQF 127

Query: 141 TLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGER 200
           ++  LRNFG+GK+S+EERI EE   L   +++  G+PFDP F ++ +VSNIICS+ FG R
Sbjct: 128 SIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGSR 187

Query: 201 FEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSH 260
           F+Y D     +++L+++   + +S   +LY++FP ++ ++PGPHQ +F N+K L+  ++H
Sbjct: 188 FDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDLIAH 247

Query: 261 MIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTL 320
            +  H+   +P   RDFI  +L +M++   +P S FH + L+ +T +L F GT+T STTL
Sbjct: 248 SVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTTL 307

Query: 321 RWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNV 380
             A L +  YP++Q +VQ EID V+G+ + P+   R +MPYT+AVIHEVQR  +IIP+N+
Sbjct: 308 HHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMNL 367

Query: 381 PREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE-NGQFKKREAFM 439
           P  VT DT   G+ +PKGT ++T L  +H DP+++ TP  FNP+HFL+ N  FKK  AFM
Sbjct: 368 PHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFM 427

Query: 440 PFSIGKRACLGEQLARTELFIFFTSLMQKFTFRP---PNNEKLSLKFRMGITISPVSHRL 496
           PFS G+R CLGE LAR ELF++ T+++Q F+ +P   P +  L+     G+   P   +L
Sbjct: 428 PFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLT-PLSSGLGNLPRPFQL 486

Query: 497 CAVPQ 501
           C  P+
Sbjct: 487 CLRPR 491


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  390 bits (1003), Expect = e-108
 Identities = 200/483 (41%), Positives = 297/483 (61%), Gaps = 8/483 (1%)

Query: 20  TLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLF 79
           TLL      +L + + +R+     PPGP  LPF+GN+  ++ EQ +  +    ++YG +F
Sbjct: 10  TLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVF 69

Query: 80  SLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRR 139
           ++ LG    V++ G   +KEAL+   + F  R      + +FK  G+  S+G+  K+ RR
Sbjct: 70  TIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRR 129

Query: 140 FTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGE 199
           F++  LR FG+GK+ +EERIQEEA  L +A++  +G   DP F ++  VSN+I SI FG+
Sbjct: 130 FSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGD 189

Query: 200 RFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVS 259
           RF+Y+D  F  LL+++       A+ T QLY +F  +MK LPGP Q  F   + L+ F++
Sbjct: 190 RFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIA 249

Query: 260 HMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTT 319
             ++ +++  +P   RDFID++L  M +   NP + F+ +NL+ +TL+LFFAGTET STT
Sbjct: 250 KKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTT 309

Query: 320 LRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLN 379
           LR+  L +  +PE++ KV  EIDRVIG+ +QP    R  MPYT AVIHE+QR G+++P+ 
Sbjct: 310 LRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMG 369

Query: 380 VPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE-NGQFKKREAF 438
           +   V  DT    + LPKGT +   L ++ RDP  ++ P  FNP HFL+  GQFKK +AF
Sbjct: 370 LAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAF 429

Query: 439 MPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCA 498
           +PFSIGKR C GE LAR ELF+FFT++MQ F F+ P + K        I +SP       
Sbjct: 430 VPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPK-------DIDVSPKHVGFAT 482

Query: 499 VPQ 501
           +P+
Sbjct: 483 IPR 485


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  384 bits (985), Expect = e-106
 Identities = 195/482 (40%), Positives = 297/482 (61%), Gaps = 8/482 (1%)

Query: 21  LLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFS 80
           LL+     +L + + +R+     PPGP  LPF+GN+  ++ EQ +  +    ++YG +F+
Sbjct: 11  LLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFT 70

Query: 81  LELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRF 140
           + LG    V++ G   ++EAL+   + F  R      + +FK  G++ S+G+  K+ RRF
Sbjct: 71  IHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRF 130

Query: 141 TLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGER 200
           ++  LR+FG+GK+ +EERIQEEA  L +A++   G   DP F ++  VSN+I SI FG+R
Sbjct: 131 SIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDR 190

Query: 201 FEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSH 260
           F+Y+D  F  LL+++  +    ++ T QLY +F  +MK LPGP Q  F   + L+ F++ 
Sbjct: 191 FDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAK 250

Query: 261 MIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTL 320
            ++ +++  +P   RDFID++L  M +   NP + F+ +NL+ +TL+LF  GTET STTL
Sbjct: 251 KVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTL 310

Query: 321 RWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNV 380
           R+  L +  +PE++ KV  EIDRVIG+ +QP    R  MPY  AVIHE+QR G++IP+++
Sbjct: 311 RYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSL 370

Query: 381 PREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFL-ENGQFKKREAFM 439
            R V  DT    + LPKGT +   L ++ RDP+ ++ P  FNP HFL E GQFKK +AF+
Sbjct: 371 ARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFV 430

Query: 440 PFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCAV 499
           PFSIGKR C GE LAR ELF+FFT++MQ F  +   + K        I +SP       +
Sbjct: 431 PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPK-------DIDVSPKHVGFATI 483

Query: 500 PQ 501
           P+
Sbjct: 484 PR 485


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  382 bits (982), Expect = e-106
 Identities = 193/444 (43%), Positives = 275/444 (61%), Gaps = 4/444 (0%)

Query: 35  LKRRRPKNY---PPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLI 91
           L +R P  +   PPGP  LP LGN   +D          F +KYG++F++ LG    V++
Sbjct: 19  LVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVML 78

Query: 92  TGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLG 151
            G+  I+EAL+   + F  R    M +  F+  G+I ++G  WK  RRF++T +R+FG+G
Sbjct: 79  CGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMG 138

Query: 152 KKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQL 211
           K+S+EERIQEEAQ L E +++  G   DP F   +  +NIICSI FG+RF YQD  F ++
Sbjct: 139 KRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKM 198

Query: 212 LKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNP 271
           L L  +   L +S   QL+ +F   +K+ PG H+ ++ N +++  ++ H ++KHR+  +P
Sbjct: 199 LNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDP 258

Query: 272 AETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYP 331
           +  +D ID YL  M K   N  S F  +NL  +TL LFFAGTETTSTTLR+  L M  YP
Sbjct: 259 SAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYP 318

Query: 332 EIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLA 391
            + E+V  EI++VIG  + P    R  MPYT AVI+E+QR  +++P+ VP  VT  T+  
Sbjct: 319 HVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR 378

Query: 392 GYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE-NGQFKKREAFMPFSIGKRACLG 450
           GY +PK T +   L+    DP  +  PD FNPDHFL+ NG  KK EAF+PFS+GKR CLG
Sbjct: 379 GYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLG 438

Query: 451 EQLARTELFIFFTSLMQKFTFRPP 474
           E +AR ELF+FFT+++Q F+   P
Sbjct: 439 EGIARAELFLFFTTILQNFSMASP 462


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  376 bits (966), Expect = e-104
 Identities = 206/483 (42%), Positives = 295/483 (61%), Gaps = 10/483 (2%)

Query: 28  FLLAADFLKRRR--PKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGD 85
           FLL  D + RR+     YPPGP  LP LGN   VDF+ +        +++G++FSL+L  
Sbjct: 16  FLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAW 75

Query: 86  ISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIF---KKNGLIMSS-GQAWKEQRRFT 141
              V++ GL  ++EAL+   ++  +RP  P+ + +    +  G+ ++  G AW+EQRRF+
Sbjct: 76  TPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFS 135

Query: 142 LTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERF 201
           ++ LRN GLGKKSLE+ + EEA  L  A    +G+PF P+  ++ AVSN+I S+T G RF
Sbjct: 136 VSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRF 195

Query: 202 EYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHM 261
           EY D  F +LL L  E    E+    ++ N  P ++  +P     +    K     +  +
Sbjct: 196 EYDDPRFLRLLDLAQEGLKEESGFLREVLNAVP-VLLHIPALAGKVLRFQKAFLTQLDEL 254

Query: 262 IDKHRKDWNPAE-TRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTL 320
           + +HR  W+PA+  RD  +A+L EM K  GNP SSF++ENL     DLF AG  TTSTTL
Sbjct: 255 LTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTL 314

Query: 321 RWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNV 380
            W LL M L+P++Q +VQ EID VIGQ ++P    +  MPYT AVIHEVQR G+I+PL V
Sbjct: 315 AWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGV 374

Query: 381 PREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE-NGQFKKREAFM 439
               + D  + G+ +PKGT ++TNL+++ +D   W  P  F+P+HFL+  G F K EAF+
Sbjct: 375 THMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFL 434

Query: 440 PFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNE-KLSLKFRMGITISPVSHRLCA 498
           PFS G+RACLGE LAR ELF+FFTSL+Q F+F  P  + + S        ++P  + LCA
Sbjct: 435 PFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCA 494

Query: 499 VPQ 501
           VP+
Sbjct: 495 VPR 497


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  375 bits (964), Expect = e-104
 Identities = 191/459 (41%), Positives = 286/459 (62%), Gaps = 1/459 (0%)

Query: 21  LLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFS 80
           LL      +L + + +R+     PPGP  LPF+GN+  ++ E     +  F + YG +F+
Sbjct: 11  LLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPVFT 70

Query: 81  LELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRF 140
           + LG    V++ G   ++EAL+   + F  R      + +FK  G+  S+G+  K+  RF
Sbjct: 71  IHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLLRF 130

Query: 141 TLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGER 200
            +  LR+FG+GK+ +EERIQEE+  L EAI+  +G   DP F ++  VSN+I SI FG+R
Sbjct: 131 AIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDR 190

Query: 201 FEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSH 260
           F+Y+D  F  LL ++  +    ++ T QLY +F  +MK LPGP Q  F   + L+ F++ 
Sbjct: 191 FDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAK 250

Query: 261 MIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTL 320
            ++ +++  +P   +DFID++L  M +   NP + F+ +NL+ STL+LF AGTET STTL
Sbjct: 251 KVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTL 310

Query: 321 RWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNV 380
           R+  L +  +PE++ KV  EIDRVIG+ +QP    R  MPY  AVIHE+QR G++IP+++
Sbjct: 311 RYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSL 370

Query: 381 PREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLEN-GQFKKREAFM 439
            R V  DT    + LPKGT +   L ++ RDP+ ++ P  FNP HFL++ GQFKK +AF+
Sbjct: 371 ARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFV 430

Query: 440 PFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEK 478
           PFSIGKR C GE LAR ELF+FFT++MQ F  +   + K
Sbjct: 431 PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPK 469


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  370 bits (950), Expect = e-102
 Identities = 196/489 (40%), Positives = 288/489 (58%), Gaps = 4/489 (0%)

Query: 16  VHPRTLLLGTVAFLLAADFLKRR-RPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKK 74
           + P  +L+  ++F+L     ++  R +  PPGP  LP +GN   +D +        F K 
Sbjct: 1   MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV 60

Query: 75  YGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAW 134
           YG +F++  G    V+  G   +KEALI   + F  R  +P+ + I K  G+I S+G+ W
Sbjct: 61  YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW 120

Query: 135 KEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICS 194
           KE RRF+LT LRNFG+GK+S+E+R+QEEA  L E +++    P DP F +  A  N+ICS
Sbjct: 121 KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 195 ITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKL 254
           + F +RF+Y+D  F  L+K  +E   +  S   Q+ N FP ++   PG H  +  N    
Sbjct: 181 VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT 240

Query: 255 KLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTE 314
           + ++   + +H+   +    RDFID +L +M +   N  S F+ ENL+ +  DLF AGTE
Sbjct: 241 RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE 300

Query: 315 TTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGN 374
           TTSTTLR+ LL +  +PE+  KVQ EID VIG+ + P    R  MPYT+AV+HE+QR  +
Sbjct: 301 TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD 360

Query: 375 IIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE-NGQFK 433
           ++P  VP  VT DT    Y +PKGT I+  LT++  D  E+  P+ F+P HFL+ NG FK
Sbjct: 361 LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK 420

Query: 434 KREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEK--LSLKFRMGITISP 491
           K + FMPFS GKR C GE LAR ELF+F T+++Q F  +  ++ K   +     GI   P
Sbjct: 421 KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP 480

Query: 492 VSHRLCAVP 500
            S+++C +P
Sbjct: 481 PSYQICFIP 489


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  363 bits (933), Expect = e-100
 Identities = 194/485 (40%), Positives = 283/485 (58%), Gaps = 7/485 (1%)

Query: 22  LLGTVAFLLAADFLKRRRPK-NYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFS 80
           LL   AFLL     ++     N PPGP+ LP +GN F ++ +          +++G +F+
Sbjct: 10  LLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFT 69

Query: 81  LELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRF 140
           L +G    V++ G   +KEAL+     F  R   P   H  +  G+I ++G  WK+ RRF
Sbjct: 70  LYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIRRF 128

Query: 141 TLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGER 200
           +LT LRN+G+GK+  E RIQ EA  L EA+++  GQPFDP F I  A  N+I  I F + 
Sbjct: 129 SLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKH 188

Query: 201 FEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSH 260
           F+Y D  F +L+ L +E  +L ++   QLYN FP  + +LPG H+ +  N  ++K +VS 
Sbjct: 189 FDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSE 248

Query: 261 MIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTL 320
            + +H +  +P   RD  D  L EM K   +    +  + +  +  DLFFAGTETTSTTL
Sbjct: 249 RVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTL 308

Query: 321 RWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNV 380
           R+ LL +  YPEI+EK+  EIDRVIG  + P+   R+ MPY +AV+HE+QR   ++P N+
Sbjct: 309 RYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNL 368

Query: 381 PREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFL-ENGQFKKREAFM 439
           P E T DT   GY +PKGT+++  L ++  D  E+  P+ F P+HFL ENG+FK  + F 
Sbjct: 369 PHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFK 428

Query: 440 PFSIGKRACLGEQLARTELFIFFTSLMQKFTFRP---PNNEKLSLKFRMGITISPVSHRL 496
           PFS GKR C GE LAR ELF+   +++Q F  +P   P +  LS    +G    P  ++L
Sbjct: 429 PFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLS-PIHIGFGCIPPRYKL 487

Query: 497 CAVPQ 501
           C +P+
Sbjct: 488 CVIPR 492


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  363 bits (931), Expect = e-100
 Identities = 187/458 (40%), Positives = 279/458 (60%), Gaps = 8/458 (1%)

Query: 44  PPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIH 103
           P GP  LP +GN   +D +     +  F K YG +F++  G    V++ G   +KEALI 
Sbjct: 30  PSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALID 89

Query: 104 MDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEA 163
             + F  R   P+ E + K  G++ S+G+ WKE RRF L  LRNFG+GK+S+E+R+QEEA
Sbjct: 90  HGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEA 149

Query: 164 QHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEA 223
           + L E +++ N  P DP F +  A  N+ICS+ F +RF+Y+D  F  L++  +E   + +
Sbjct: 150 RCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILS 209

Query: 224 SKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLK 283
           S   Q+ N FP ++ +LPG H  +  N+  +K +V   I +H++  +    RDFID +L 
Sbjct: 210 SPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLI 269

Query: 284 EMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDR 343
           +M +   N  S F  E+LI +  D+F AGTETTSTTLR+ LL +  YPE+  KVQ EI+ 
Sbjct: 270 KMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIEC 329

Query: 344 VIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILT 403
           V+G+ + P    R  MPYT+AV+HE+QR  +++P N+P  VT D     Y +PKGT I+T
Sbjct: 330 VVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIIT 389

Query: 404 NLTALHRDPTEWATPDTFNPDHFLE-NGQFKKREAFMPFSIGKRACLGEQLARTELFIFF 462
           +LT++  +  E+  P+ F+P HFL+ +G FKK + FMPFS GKR C+GE LAR ELF+F 
Sbjct: 390 SLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFL 449

Query: 463 TSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCAVP 500
           T+++Q F  +   + K        I I+P+++    VP
Sbjct: 450 TTILQNFNLKSQVDPK-------DIDITPIANAFGRVP 480


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  361 bits (926), Expect = e-99
 Identities = 192/460 (41%), Positives = 276/460 (60%), Gaps = 3/460 (0%)

Query: 44  PPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIH 103
           PPGP  LP +GN   +D +     +    K YG +F+L  G    V++ G  ++KEALI 
Sbjct: 30  PPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALID 89

Query: 104 MDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEA 163
           + + F  R   P+ E   +  G++ S+G+ WKE RRF+L  LRNFG+GK+S+E+R+QEEA
Sbjct: 90  LGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEA 149

Query: 164 QHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEA 223
           + L E +++    P DP F +  A  N+ICSI F +RF+Y+D  F  L++ L+E   + +
Sbjct: 150 RCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVS 209

Query: 224 SKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLK 283
           +   Q+ N FP I+ + PG H  L  N   ++  +   + +H++  +    RDFID +L 
Sbjct: 210 TPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLI 269

Query: 284 EMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDR 343
           +M K   N  S F  ENL+ +  DL  AGTETTSTTLR+ALL +  +PE+  KVQ EI+R
Sbjct: 270 KMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 329

Query: 344 VIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILT 403
           VIG+ + P    R  MPYT+AV+HEVQR  ++IP ++P  VT D     Y +PKGT ILT
Sbjct: 330 VIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILT 389

Query: 404 NLTALHRDPTEWATPDTFNPDHFL-ENGQFKKREAFMPFSIGKRACLGEQLARTELFIFF 462
           +LT++  D  E+  P+ F+P HFL E G FKK   FMPFS GKR C+GE LAR ELF+F 
Sbjct: 390 SLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFL 449

Query: 463 TSLMQKFTFRPPNNEK--LSLKFRMGITISPVSHRLCAVP 500
           T ++Q F  +   + K   +     G    P  ++LC +P
Sbjct: 450 TFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP 489


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  357 bits (917), Expect = 1e-98
 Identities = 190/462 (41%), Positives = 277/462 (59%), Gaps = 7/462 (1%)

Query: 44  PPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIH 103
           PPGP  LP +GN   +  +     +    K YG +F+L  G    V++ G   +KEALI 
Sbjct: 30  PPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 89

Query: 104 MDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEA 163
           + + F  R + P+ E   +  G++ S+G+ WKE RRF+L  LRNFG+GK+S+E+R+QEEA
Sbjct: 90  LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEA 149

Query: 164 QHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEA 223
           + L E +++    P DP F +  A  N+ICSI F +RF+Y+D  F  L++ L+E   + +
Sbjct: 150 RCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILS 209

Query: 224 SKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLK 283
           S   Q+ N F  I+ + PG H  L  N   +K ++   + +H++  +    +DFID +L 
Sbjct: 210 SPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLM 269

Query: 284 EMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDR 343
           +M K   N  S F  E+L  + +DLF AGTETTSTTLR+ALL +  +PE+  KVQ EI+R
Sbjct: 270 KMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 329

Query: 344 VIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILT 403
           VIG+ + P    R  MPYT+AV+HEVQR  +++P ++P  VT D     Y +PKGT IL 
Sbjct: 330 VIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILI 389

Query: 404 NLTALHRDPTEWATPDTFNPDHFL-ENGQFKKREAFMPFSIGKRACLGEQLARTELFIFF 462
           +LT++  D  E+  P+ F+P HFL E G FKK + FMPFS GKR C+GE LA  ELF+F 
Sbjct: 390 SLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFL 449

Query: 463 TSLMQKFTFR----PPNNEKLSLKFRMGITISPVSHRLCAVP 500
           TS++Q F  +    P N +   +    G    P  ++LC +P
Sbjct: 450 TSILQNFNLKSLVDPKNLDTTPVV--NGFASVPPFYQLCFIP 489


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  353 bits (906), Expect = 2e-97
 Identities = 199/498 (39%), Positives = 294/498 (59%), Gaps = 28/498 (5%)

Query: 21  LLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNF-------FL------------VDF 61
           LL G VA LL   +L+RRR +  PPGP   P +GNF       FL               
Sbjct: 38  LLCGLVA-LLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGI 96

Query: 62  EQSHLEVQLFV----KKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMR 117
           + S +  Q+ +    + YG++FS  +G    V+++    ++EAL+   + F +RP  P+ 
Sbjct: 97  DPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLI 156

Query: 118 EHIFKKNGLIMSS-GQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQ 176
             + K+ G++ +  G  W++QR+F+ + LR+FGLGK SLE +I EE +++   +++    
Sbjct: 157 SIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGED 216

Query: 177 PFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWI 236
           PF P   I+NAVSNIICS+ FG+RF+Y +S F+++L  +     +  +    L N+ PW+
Sbjct: 217 PFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWL 276

Query: 237 MKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHT-GNPTSS 295
                GP + L    K +  F+  +I  H++  +    +DFID YL  M +    N  SS
Sbjct: 277 YYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSS 336

Query: 296 FHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAA 355
           F EE L     DLF AGT+TT+ +L W LLYM+L P++QEKV  EI+RVIG  + PS   
Sbjct: 337 FDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTD 396

Query: 356 RESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEW 415
           +  MPYT A I EVQR+  ++PL +P   + +T L GY +PKGT+IL NL ++HRDP  W
Sbjct: 397 KAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIW 456

Query: 416 ATPDTFNPDHFLEN-GQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFR-P 473
             P+ F P+ FL++ GQ  K+E F+PF IGKR C+GEQLA+ ELF+ F SLMQ F F  P
Sbjct: 457 EKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALP 516

Query: 474 PNNEKLSLKFRMGITISP 491
            +++K  L  R G+T++P
Sbjct: 517 EDSKKPLLTGRFGLTLAP 534


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  337 bits (864), Expect = 1e-92
 Identities = 181/478 (37%), Positives = 278/478 (58%), Gaps = 9/478 (1%)

Query: 9   AAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEV 68
           A   WA++    LLL     LL       R   + PPGP  LP LGN   +     +  +
Sbjct: 3   ATGTWALLLALALLL-----LLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGL 57

Query: 69  QLFVKKYGNLFSLELGDISAVLI-TGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLI 127
               KKYG +F++ LG    V++  G   ++EAL    + F  R    M E  F  +G+ 
Sbjct: 58  MRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVF 117

Query: 128 MSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNA 187
            S+G+ W++ R+FT+ ALR+ G+GK+  EE IQ EA+ L E  +   G+PFDP   +  A
Sbjct: 118 FSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQA 177

Query: 188 VSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTL 247
            SN++CS+ FG RF Y+D  FQ +++         +S+  Q Y +F W ++ LPGPH+ L
Sbjct: 178 TSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQL 237

Query: 248 FSNWKKLKLFVSHMIDKHRKDWNPA-ETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTL 306
             +   L  F    + +H+ + + +   RD +DA+L +M++   NP + F  +N++ + +
Sbjct: 238 LHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVI 297

Query: 307 DLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVI 366
            L FAGT T STT+ + LL +  YP +Q+ V+ E++R +G GQ PS   R  +PYT+AV+
Sbjct: 298 YLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVL 357

Query: 367 HEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHF 426
           HE QR+  ++P+ +PR +   T   GY LP+GT +   L ++  DP  +  P+ FNPD F
Sbjct: 358 HEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRF 417

Query: 427 LE-NGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPP-NNEKLSLK 482
           L+ +G+F+K EAF+PFS+GKR CLGE LA+ ELF+FFT+++Q F+   P   + LSLK
Sbjct: 418 LDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLK 475


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  330 bits (845), Expect = 2e-90
 Identities = 178/459 (38%), Positives = 265/459 (57%), Gaps = 52/459 (11%)

Query: 21  LLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFS 80
           LL      +L + + +R+     PPGP  LPF+GN+  ++ E                  
Sbjct: 11  LLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEH----------------- 53

Query: 81  LELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRF 140
                           I ++++ + Q                  G+  S+G+  K+  RF
Sbjct: 54  ----------------ICDSIMKVSQ------------------GVAFSNGERAKQLLRF 79

Query: 141 TLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGER 200
            +  LR+FG+GK+ +EERIQEE+  L EAI+  +G   DP F ++  VSN+I SI FG+R
Sbjct: 80  AIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDR 139

Query: 201 FEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSH 260
           F+Y+D  F  LL ++  +    ++ T QLY +F  +MK LPGP Q  F   + L+ F++ 
Sbjct: 140 FDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAK 199

Query: 261 MIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTL 320
            ++ +++  +P   +DFID++L  M +   NP + F+ +NL+ STL+LF AGTET STTL
Sbjct: 200 KVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTL 259

Query: 321 RWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNV 380
           R+  L +  +PE++ KV  EIDRVIG+ +QP    R  MPY  AVIHE+QR G++IP+++
Sbjct: 260 RYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSL 319

Query: 381 PREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLEN-GQFKKREAFM 439
            R V  DT    + LPKGT +   L ++ RDP+ ++ P  FNP HFL++ GQFKK +AF+
Sbjct: 320 ARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFV 379

Query: 440 PFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEK 478
           PFSIGKR C GE LAR ELF+FFT++MQ F  +   + K
Sbjct: 380 PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPK 418


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  330 bits (845), Expect = 2e-90
 Identities = 179/464 (38%), Positives = 275/464 (59%), Gaps = 10/464 (2%)

Query: 43  YPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALI 102
           +PPGP  LP +GN  L+   Q    +    ++YG +F++ LG    V++TG   +KEAL 
Sbjct: 31  WPPGPRPLPLVGNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALA 90

Query: 103 HMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEE 162
              Q   +RP   + + I +  G+  SSG  W+  R+FT+ AL + G+G++ + ++I +E
Sbjct: 91  GPGQELADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKILQE 150

Query: 163 AQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLE 222
            + L+  +    G+PF P   +  A SNI  ++ FG RF+Y+D  F  LL L+DEV  L 
Sbjct: 151 LKCLSGQLDGYRGRPF-PLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLL 209

Query: 223 ASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAE-TRDFIDAY 281
            S   QL+NV+PW+   L   H+ +    ++++  +  +++  R    P +    ++DA 
Sbjct: 210 GSPGLQLFNVYPWLGALLQ-LHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVCSYVDAL 268

Query: 282 LKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEI 341
           +++      +P   F E N +  TLD+  AGTETTS TL+WA L M  +P++Q +VQ E+
Sbjct: 269 IQQ--GQGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEEL 326

Query: 342 DRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMI 401
           DRV+G G+ P    ++++PYT+AV+HEVQR   ++P +VPR    DT L G+ LPKGT +
Sbjct: 327 DRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLLPKGTPV 385

Query: 402 LTNLTALHRDPTEWATPDTFNPDHFLE-NGQFKKREAFMPFSIGKRACLGEQLARTELFI 460
           +  LT++  D T+W TP  FNP HFL+ NG F KREAF+PFS G+R C+GE+LARTELF+
Sbjct: 386 IPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELFL 445

Query: 461 FFTSLMQKFTFRPP---NNEKLSLKFRMGITISPVSHRLCAVPQ 501
            F  L+Q++   PP   +   L        T+ P +  LCAVP+
Sbjct: 446 LFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPRAQALCAVPR 489


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  316 bits (810), Expect = 3e-86
 Identities = 184/479 (38%), Positives = 263/479 (54%), Gaps = 53/479 (11%)

Query: 28  FLLAADFLKRRR--PKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGD 85
           FLL  D + RR+     YPPGP  LP LGN   VDF+ +        +++G++FSL+L  
Sbjct: 16  FLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAW 75

Query: 86  ISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTAL 145
              V++ GL  ++EAL+   ++  +RP  P+ + +                         
Sbjct: 76  TPVVVLNGLAAVREALVTHGEDTADRPPVPITQIL------------------------- 110

Query: 146 RNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQD 205
              G G +S                    G+PF P+  ++ AVSN+I S+T G RFEY D
Sbjct: 111 ---GFGPRS-------------------QGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD 148

Query: 206 SWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKH 265
             F +LL L  E    E+    ++ N  P ++  +P     +    K     +  ++ +H
Sbjct: 149 PRFLRLLDLAQEGLKEESGFLREVLNAVP-VLLHIPALAGKVLRFQKAFLTQLDELLTEH 207

Query: 266 RKDWNPAET-RDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWAL 324
           R  W+PA+  RD  +A+L EM K  GNP SSF++ENL     DLF AG  TTSTTL W L
Sbjct: 208 RMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGL 267

Query: 325 LYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREV 384
           L M L+P++Q +VQ EID VIGQ ++P    +  MPYT AVIHEVQR G+I+PL V    
Sbjct: 268 LLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMT 327

Query: 385 TVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE-NGQFKKREAFMPFSI 443
           + D  + G+ +PKGT ++TNL+++ +D   W  P  F+P+HFL+  G F K EAF+PFS 
Sbjct: 328 SRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSA 387

Query: 444 GKRACLGEQLARTELFIFFTSLMQKFTFRPPNNE-KLSLKFRMGITISPVSHRLCAVPQ 501
           G+RACLGE LAR ELF+FFTSL+Q F+F  P  + + S        ++P  + LCAVP+
Sbjct: 388 GRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVPR 446


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  304 bits (778), Expect = 1e-82
 Identities = 172/458 (37%), Positives = 250/458 (54%), Gaps = 67/458 (14%)

Query: 44  PPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIH 103
           P GP  LP +GN   +D +     +  F K YG +F++  G    V++ G   +KEALI 
Sbjct: 30  PSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALID 89

Query: 104 MDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEA 163
             + F  R   P+ E + K  G++ S+G+ WKE RRF L  LRNFG+GK+S+E+R+QEEA
Sbjct: 90  HGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEA 149

Query: 164 QHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEA 223
           + L E +++ N  P DP F +  A  N+ICS+ F +RF+Y+D  F  L++  +E   + +
Sbjct: 150 RCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILS 209

Query: 224 SKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLK 283
           S         PWI                          +KH                  
Sbjct: 210 S---------PWIQ-------------------------EKH------------------ 217

Query: 284 EMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDR 343
                  N  S F  E+LI +  D+F AGTETTSTTLR+ LL +  YPE+  KVQ EI+ 
Sbjct: 218 -------NQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIEC 270

Query: 344 VIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILT 403
           V+G+ + P    R  MPYT+AV+HE+QR  +++P N+P  VT D     Y +PKGT I+T
Sbjct: 271 VVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIIT 330

Query: 404 NLTALHRDPTEWATPDTFNPDHFLE-NGQFKKREAFMPFSIGKRACLGEQLARTELFIFF 462
           +LT++  +  E+  P+ F+P HFL+ +G FKK + FMPFS GKR C+GE LAR ELF+F 
Sbjct: 331 SLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFL 390

Query: 463 TSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCAVP 500
           T+++Q F  +   + K        I I+P+++    VP
Sbjct: 391 TTILQNFNLKSQVDPK-------DIDITPIANAFGRVP 421


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  246 bits (629), Expect = 3e-65
 Identities = 149/482 (30%), Positives = 256/482 (53%), Gaps = 27/482 (5%)

Query: 36  KRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLP 95
           +RR+ ++ PPGP+  P +GN   V  + +HL      ++YG++F + LG    V++ G  
Sbjct: 43  RRRQLRSAPPGPFAWPLIGNAAAVG-QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGER 101

Query: 96  LIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSG---QAWKEQRRFTLTALRNFGL-- 150
            I +AL+     F +RP       +    G  M+ G   + WK QRR   + +RNF    
Sbjct: 102 AIHQALVQQGSAFADRPAFASFRVV--SGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQ 159

Query: 151 --GKKSLEERIQEEAQHLTEAIKE--ENGQPFDPHFKINNAVSNIICSITFGERFEYQDS 206
              ++ LE  +  EA+ L   +     +G   DP      AV+N++ ++ FG R+ + D 
Sbjct: 160 PRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDP 219

Query: 207 WFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKL-KLFVSHMIDK- 264
            F++LL   +E      + +  L +V PW+  F P P +T+F  +++L + F + ++DK 
Sbjct: 220 EFRELLSHNEEFGRTVGAGS--LVDVMPWLQYF-PNPVRTVFREFEQLNRNFSNFILDKF 276

Query: 265 --HRKDWNP-AETRDFIDAYLKEMSKHTGNPT----SSFHEENLICSTLDLFFAGTETTS 317
             H +   P A  RD +DA++    K     +    +    EN+  +  D+F A  +T S
Sbjct: 277 LRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLS 336

Query: 318 TTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIP 377
           T L+W LL    YP++Q +VQAE+D+V+G+ + P    + ++PY  A ++E  R  + +P
Sbjct: 337 TALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVP 396

Query: 378 LNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE-NGQFKK-- 434
           + +P   T +T++ GYH+PK T++  N  +++ DP +W  P+ F+P  FL+ +G   K  
Sbjct: 397 VTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDL 456

Query: 435 REAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSH 494
               M FS+GKR C+GE+L++ +LF+F + L  +  FR   NE   + F  G+TI P S 
Sbjct: 457 TSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSF 516

Query: 495 RL 496
           ++
Sbjct: 517 KV 518


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  239 bits (610), Expect = 4e-63
 Identities = 149/501 (29%), Positives = 251/501 (50%), Gaps = 35/501 (6%)

Query: 22  LLGTVAFLLAADFLKRRRPK-----NYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYG 76
           LL +V F L    ++  RP+       PPGPW  P +G+   +  +  HL +    ++YG
Sbjct: 13  LLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYG 71

Query: 77  NLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMS----SGQ 132
           ++  + +G    V+++GL  I++AL+    +F  RP   +       NG  MS    SG 
Sbjct: 72  DVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRP--DLYTFTLISNGQSMSFSPDSGP 129

Query: 133 AWKEQRRFTLTALRNFGLGKKS-------LEERIQEEAQHLTEAIKEENGQP--FDPHFK 183
            W  +RR     L++F +           LEE + +EA+ L   ++E    P  F+P+  
Sbjct: 130 VWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRY 189

Query: 184 INNAVSNIICSITFGERFEYQDSWFQQLLKLLD-EVTYLEASKTCQLYNVFPWIMKFLPG 242
           +  +V+N+IC+I FG R+++     Q+LL L++    + E   +    +  P I+++LP 
Sbjct: 190 VVVSVTNVICAICFGRRYDHNH---QELLSLVNLNNNFGEVVGSGNPADFIP-ILRYLPN 245

Query: 243 PHQTLFSNW-KKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHT--GNPTSSFHEE 299
           P    F +  +K   F+  M+ +H K +     RD  D+ ++   +     N      +E
Sbjct: 246 PSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDE 305

Query: 300 NLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESM 359
            +I   LDLF AG +T +T + W+L+Y+ + P +Q K+Q E+D VIG+ ++P  + R  +
Sbjct: 306 KIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHL 365

Query: 360 PYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPD 419
           PY  A I E  R  + +P  +P   T DT+L G+++PKG  +  N   ++ D   W  P 
Sbjct: 366 PYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPS 425

Query: 420 TFNPDHFL-ENGQFKK--REAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNN 476
            F P+ FL  +G   K   E  + F +GKR C+GE +AR E+F+F   L+Q+  F  P  
Sbjct: 426 EFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLG 485

Query: 477 EKLSLKFRMGITISPVSHRLC 497
            K+ +    G+T   + H  C
Sbjct: 486 VKVDMTPIYGLT---MKHACC 503


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  231 bits (589), Expect = 1e-60
 Identities = 147/490 (30%), Positives = 239/490 (48%), Gaps = 25/490 (5%)

Query: 21  LLLGTVAFLLAADFLKRRRPK-----NYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKY 75
           LLL +  F L    LK  RP+       PP PW  P LG+   +  +  HL +    ++Y
Sbjct: 14  LLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRY 72

Query: 76  GNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMS--SGQA 133
           G++  + +G    ++++ L  I++AL+    +F  RP       I     L  S  SG  
Sbjct: 73  GDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPV 132

Query: 134 WKEQRRFTLTALRNFGLGKKS-------LEERIQEEAQHLTEAIKEENGQP--FDPHFKI 184
           W  +RR    AL  F +           LEE + +EA+ L   ++E    P  FDP+ ++
Sbjct: 133 WAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQV 192

Query: 185 NNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPH 244
             +V+N+I ++ FG+ F         L+K   E  ++E + +    + FP I+++LP P 
Sbjct: 193 VVSVANVIGAMCFGQHFPESSDEMLSLVKNTHE--FVETASSGNPLDFFP-ILRYLPNPA 249

Query: 245 QTLFSNWKKLKL-FVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLIC 303
              F  + +  L F+   + +H +D++    RD   A  K   K      +   +E ++ 
Sbjct: 250 LQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVN 309

Query: 304 STLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTN 363
              D+F AG +T +T + W+L+Y+   PEIQ K+Q E+D VIG+ ++P  + R  +PY  
Sbjct: 310 LVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLE 369

Query: 364 AVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNP 423
           A I E  R  + +P  +P   T DTTL G+++PK   +  N   ++ DP  W  P  F P
Sbjct: 370 AFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRP 429

Query: 424 DHFL--ENGQFKK--REAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKL 479
           + FL  +     K   E  M F +GKR C+GE LA+ E+F+F   L+Q+  F  P   K+
Sbjct: 430 ERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV 489

Query: 480 SLKFRMGITI 489
            L    G+T+
Sbjct: 490 DLTPIYGLTM 499


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  198 bits (504), Expect = 8e-51
 Identities = 130/419 (31%), Positives = 217/419 (51%), Gaps = 18/419 (4%)

Query: 73  KKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQ 132
           +K+G ++ L LG    V++     I+EA++    +F  RP  P+   +  +N   +S G 
Sbjct: 54  QKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP-EPLTYKLVSRNYPDLSLGD 112

Query: 133 ---AWKEQRRFTLTALRNFGLG-KKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAV 188
               WK  ++ T +AL    LG + S+E  +++  Q   E ++ + G P     + +   
Sbjct: 113 YSLLWKAHKKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLT 169

Query: 189 SNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPH-QTL 247
            +IIC +TFG++ +  D+      K + EV    +  + Q+ +V P++ +F P P  + L
Sbjct: 170 CSIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFPNPGLRRL 227

Query: 248 FSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSS-FHEENLICSTL 306
               +K    V   + +H++     + RD +D  L+ +++ +    S    E ++  + +
Sbjct: 228 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAV 287

Query: 307 DLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAA---RESMPYTN 363
           DL   GTETT+ TL WA++++  +PEIQ+++Q E+D  +G G   S      R  +P  N
Sbjct: 288 DLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLN 347

Query: 364 AVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNP 423
           A I EV R+  ++PL +P   T  ++++GY +P+GT+I+ NL   H D T W  P  F P
Sbjct: 348 ATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWP 407

Query: 424 DHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLK 482
           D FLE G   K    + F  G R CLGE LAR ELF+  T L+Q FT  P  +   SL+
Sbjct: 408 DRFLEPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQ 463


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  197 bits (500), Expect = 2e-50
 Identities = 135/481 (28%), Positives = 236/481 (49%), Gaps = 21/481 (4%)

Query: 12  LWAVVHPRTLLLGTVAFLLAADFLKRRRP-KNYPPGPWRLPFLGNF-FLVDFEQSHLEVQ 69
           +W +V    LLL T+A+L    + KRR P   YP     LP +G+  FL      H    
Sbjct: 1   MWELV---ALLLLTLAYLF---WPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFF 54

Query: 70  LFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIF--KKNGLI 127
              KKYG ++S+ +G  + V++    L KE LI   ++F  RP     +     +K    
Sbjct: 55  KLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAF 114

Query: 128 MSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNA 187
             SG  W+  RR  +     F  G + LE+ I +E   L + +   NGQ  D  F +  A
Sbjct: 115 ADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVA 174

Query: 188 VSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTL 247
           V+N+I  I F   ++  D     +    + +  ++      L ++ PW+  F     + L
Sbjct: 175 VTNVISLICFNTSYKNGDPELNVIQNYNEGI--IDNLSKDSLVDLVPWLKIFPNKTLEKL 232

Query: 248 FSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLK-EMSKHTGNP----TSSFHEENLI 302
            S+ K     ++ +++ +++ +      + +D  ++ +M+   GN      S    +N I
Sbjct: 233 KSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292

Query: 303 CSTL-DLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPY 361
            +T+ D+F AG ETT++ ++W L ++   P++++K+  EID+ +G  + P+ + R  +  
Sbjct: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352

Query: 362 TNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTF 421
             A I EV R+  + P+ +P +  VD+++  + + KGT ++ NL ALH +  EW  PD F
Sbjct: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412

Query: 422 NPDHFLE---NGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEK 478
            P+ FL            +++PF  G R+C+GE LAR ELF+    L+Q+F    P++ +
Sbjct: 413 MPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQ 472

Query: 479 L 479
           L
Sbjct: 473 L 473


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  182 bits (462), Expect = 6e-46
 Identities = 122/393 (31%), Positives = 203/393 (51%), Gaps = 19/393 (4%)

Query: 101 LIHMDQNFGN--RPVTPMREHIFKKNGLIMSSGQ---AWKEQRRFTLTALRNFGLG-KKS 154
           L+ + Q FG   R    +++ +  +N   +S G     WK  ++ T +AL    LG + S
Sbjct: 49  LLGLTQKFGPIYRLHLGLQDKLVSRNYPDLSLGDYSLLWKAHKKLTRSALL---LGIRDS 105

Query: 155 LEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKL 214
           +E  +++  Q   E ++ + G P     + +    +IIC +TFG++ +  D+      K 
Sbjct: 106 MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYYKC 164

Query: 215 LDEVTYLEASKTCQLYNVFPWIMKFLPGPH-QTLFSNWKKLKLFVSHMIDKHRKDWNPAE 273
           + EV    +  + Q+ +V P++ +F P P  + L    +K    V   + +H++     +
Sbjct: 165 IQEVLKTWSHWSIQIVDVIPFL-RFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQ 223

Query: 274 TRDFIDAYLKEMSKHTGNPTSS-FHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPE 332
            RD +D  L+ +++ +    S    E ++  + +DL   GTETT+ TL WA++++  +PE
Sbjct: 224 WRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPE 283

Query: 333 IQEKVQAEIDRVIGQGQQPSTAA---RESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTT 389
           IQ+++Q E+D  +G G   S      R  +P  NA I EV R+  ++PL +P   T  ++
Sbjct: 284 IQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSS 343

Query: 390 LAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIGKRACL 449
           ++GY +P+GT+I+ NL   H D T W  P  F PD FLE G   K    + F  G R CL
Sbjct: 344 ISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPG---KNSRALAFGCGARVCL 400

Query: 450 GEQLARTELFIFFTSLMQKFTFRPPNNEKLSLK 482
           GE LAR ELF+  T L+Q FT  P  +   SL+
Sbjct: 401 GEPLARLELFVVLTRLLQAFTLLPSGDALPSLQ 433


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score =  133 bits (334), Expect = 4e-31
 Identities = 112/457 (24%), Positives = 199/457 (43%), Gaps = 40/457 (8%)

Query: 45  PGPWRLPFLGNFFLV----DFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEA 100
           PGP   P LG+   +      ++ H  +  + KKYG +F ++LG   +V + G P + EA
Sbjct: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHL-GSPCLLEA 117

Query: 101 LIHMDQNFGNR----PVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLE 156
           L   +  +  R    P    R++  +  GL++  G+ W+  R      L   G   K L+
Sbjct: 118 LYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMK-LD 176

Query: 157 ERIQEEAQHLTEAIKE---ENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLK 213
            +I E        I E   E G   D + ++N      IC + + +RF            
Sbjct: 177 NKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGD--- 233

Query: 214 LLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSN--------WKKLKLFVSHMIDKH 265
             + V ++ A KT  + + F  +M      H++L +         W  +   V   ID  
Sbjct: 234 --EAVNFIMAIKT--MMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNR 289

Query: 266 RKDWNPAETRDFI-DAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWAL 324
            + ++   + DF+ D Y +          +   ++ L  +  +L  A  ETT+ +L W L
Sbjct: 290 LEKYSQQPSADFLCDIYHQ----------NRLSKKELYAAVTELQLAAVETTANSLMWIL 339

Query: 325 LYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREV 384
             ++  P++Q+K+  EI  V+ + Q P      +MPY  A + E  R+   +P    R +
Sbjct: 340 YNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTL 398

Query: 385 TVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIG 444
              T L  Y LPKGT+++ N   L      +     F P+ +L+  +     A +PF +G
Sbjct: 399 DKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVG 458

Query: 445 KRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSL 481
           KR C+G +LA  +L +    +++K+  +  +NE + +
Sbjct: 459 KRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEM 495


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  131 bits (329), Expect = 2e-30
 Identities = 116/461 (25%), Positives = 199/461 (43%), Gaps = 28/461 (6%)

Query: 45  PGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHM 104
           PGP  LPFLGN           +++   KKYG ++    G    + IT   +IK  L+  
Sbjct: 39  PGPTPLPFLGNILSYHKGFCMFDMECH-KKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 97

Query: 105 DQNF--GNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEE 162
             +     RP  P+    F K+ + ++  + WK  R         F  GK  L+E +   
Sbjct: 98  CYSVFTNRRPFGPVG---FMKSAISIAEDEEWKRLRSLLSPT---FTSGK--LKEMVPII 149

Query: 163 AQHLTEAIKE-----ENGQPFDPHFKINNAVSNIICSITFGERFEY----QDSWFQQLLK 213
           AQ+    ++      E G+P            ++I S +FG   +     QD + +   K
Sbjct: 150 AQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKK 209

Query: 214 LLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSN--WKKLKLFVSHMIDKHRKDWNP 271
           LL    +L+         VFP+++  L   +  +F       L+  V  M +   +D   
Sbjct: 210 LL-RFDFLDPFFLS--ITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQK 266

Query: 272 AETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYP 331
               DF+   +   +        +  +  L+  ++   FAG ETTS+ L + +  +A +P
Sbjct: 267 HRV-DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHP 325

Query: 332 EIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLA 391
           ++Q+K+Q EID V+     P+      M Y + V++E  R+   I + + R    D  + 
Sbjct: 326 DVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDVEIN 384

Query: 392 GYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHF-LENGQFKKREAFMPFSIGKRACLG 450
           G  +PKG +++    ALHRDP  W  P+ F P+ F  +N        + PF  G R C+G
Sbjct: 385 GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIG 444

Query: 451 EQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISP 491
            + A   + +    ++Q F+F+P    ++ LK  +G  + P
Sbjct: 445 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQP 485


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  130 bits (327), Expect = 3e-30
 Identities = 115/459 (25%), Positives = 200/459 (43%), Gaps = 34/459 (7%)

Query: 45  PGPWRLPFLGNFFLVDFEQSHLEVQL-FVKKYGNLFSLELGDISAVLITGLPLIKEALIH 103
           PGP  LPFLGN   + F + +    +   KKY  ++ +       + IT   +IK  L+ 
Sbjct: 39  PGPTPLPFLGN--ALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVK 96

Query: 104 MDQNF--GNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQE 161
              +     RP  P+    F KN + ++  + WK  R         F  GK  L+E +  
Sbjct: 97  ECYSVFTNRRPFGPVG---FMKNAISIAEDEEWKRIRSLLSPT---FTSGK--LKEMVPI 148

Query: 162 EAQHLTEAIKE-----ENGQPFDPHFKINNAVSNIICSITFGERFEY----QDSWFQQLL 212
            AQ+    ++      E G+P            ++I S +FG   +     QD + +   
Sbjct: 149 IAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTK 208

Query: 213 KLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPA 272
           KLL    +           VFP++   L   + T+F   +K+  F++  + K  K+    
Sbjct: 209 KLL---RFNPLDPFVLSIKVFPFLTPILEALNITVFP--RKVISFLTKSV-KQIKEGRLK 262

Query: 273 ETR----DFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMA 328
           ET+    DF+   +   +        +  +  L+  ++   FAG ETTS+ L + +  +A
Sbjct: 263 ETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELA 322

Query: 329 LYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDT 388
            +P++Q+KVQ EID V+     P+      + Y + V++E  R+   + + + R    D 
Sbjct: 323 THPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFP-VAMRLERVCKKDV 381

Query: 389 TLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHF-LENGQFKKREAFMPFSIGKRA 447
            + G  +PKG +++     LH DP  W  P+ F P+ F  +N        + PF  G R 
Sbjct: 382 EINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441

Query: 448 CLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMG 486
           C+G + A   + +    ++Q F+F+P    ++ LK R G
Sbjct: 442 CIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG 480


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  129 bits (325), Expect = 5e-30
 Identities = 113/452 (25%), Positives = 205/452 (45%), Gaps = 28/452 (6%)

Query: 45  PGPWRLPFLGN--FFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALI 102
           PGP  LPFLG   F+L        E     +KYG ++ L  G    ++I    +IK  L+
Sbjct: 39  PGPTPLPFLGTILFYLRGLWNFDRECN---EKYGEMWGLYEGQQPMLVIMDPDMIKTVLV 95

Query: 103 HMDQN-FGNR-PVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQ 160
               + F N+ P+ PM    F K+ L  +  + WK  R     A  +     K +   I 
Sbjct: 96  KECYSVFTNQMPLGPMG---FLKSALSFAEDEEWKRIRTLLSPAFTSVKF--KEMVPIIS 150

Query: 161 EEAQHLTEAIKEE--NGQPFDPHFKINNAVSNIICSITFGERFEY----QDSWFQQLLKL 214
           +    L  ++++E  N +  +          ++I    FG   +     QD + + + KL
Sbjct: 151 QCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKL 210

Query: 215 LDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAET 274
           L ++ +L+      L ++FP++       +  LF   K +  F+ + I++ ++     + 
Sbjct: 211 L-KLDFLDPFLL--LISLFPFLTPVFEALNIGLFP--KDVTHFLKNSIERMKESRLKDKQ 265

Query: 275 RDFIDAYLKEMSKHTGNPTSS---FHEENLICSTLDLFFAGTETTSTTLRWALLYMALYP 331
           +  +D + + +       T S     +  L+  ++ + FA  +TTSTTL + +  +A +P
Sbjct: 266 KHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHP 325

Query: 332 EIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLA 391
           ++Q+K+Q EID V+      +  A   M Y + V++E  R+  ++   V R    D  + 
Sbjct: 326 DVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVS-RVTRVCKKDIEIN 384

Query: 392 GYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHF-LENGQFKKREAFMPFSIGKRACLG 450
           G  +PKG  ++  + ALH DP  W  P+ F P+ F  +N        ++PF  G R C+G
Sbjct: 385 GVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIG 444

Query: 451 EQLARTELFIFFTSLMQKFTFRPPNNEKLSLK 482
            + A T + +     +Q F+F+P    ++ LK
Sbjct: 445 MRFALTNIKLAVIRALQNFSFKPCKETQIPLK 476


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  127 bits (318), Expect = 3e-29
 Identities = 113/458 (24%), Positives = 206/458 (44%), Gaps = 39/458 (8%)

Query: 45  PGPWRLPFLGN--FFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALI 102
           PGP  LPFLG   F+L        E     +KYG ++ L  G    ++I    +IK  L+
Sbjct: 39  PGPTPLPFLGTILFYLRGLWNFDRECN---EKYGEMWGLYEGQQPMLVIMDPDMIKTVLV 95

Query: 103 HMDQN-FGNR-PVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQ 160
               + F N+ P+ PM    F K+ L  +  + WK  R     A  +     K +   I 
Sbjct: 96  KECYSVFTNQMPLGPMG---FLKSALSFAEDEEWKRIRTLLSPAFTSVKF--KEMVPIIS 150

Query: 161 EEAQHLTEAIKEE--NGQPFDPHFKINNAVSNIICSITFGERFEY----QDSWFQQLLKL 214
           +    L  ++++E  N +  +          ++I    FG   +     QD + + + KL
Sbjct: 151 QCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKL 210

Query: 215 LDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAET 274
           L ++ +L+      L ++FP++       +  LF   K +  F+ + I++ ++     + 
Sbjct: 211 L-KLDFLDPFLL--LISLFPFLTPVFEALNIGLFP--KDVTHFLKNSIERMKESRLKDKQ 265

Query: 275 RDFIDAYLKEMSKHTGNPTSS---FHEENLICSTLDLFFAGTETTSTTLRWALLYMALYP 331
           +  +D + + +       T S     +  L+  ++ + FA  +TTSTTL + +  +A +P
Sbjct: 266 KHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHP 325

Query: 332 EIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLA 391
           ++Q+K+Q EID V+      +  A   M Y + V++E  R+  ++   V R    D  + 
Sbjct: 326 DVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVS-RVTRVCKKDIEIN 384

Query: 392 GYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKRE-------AFMPFSIG 444
           G  +PKG  ++  + ALH DP  W  P+ F P+      +F K+         ++PF  G
Sbjct: 385 GVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE-----SRFSKKNKDSIDLYRYIPFGAG 439

Query: 445 KRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLK 482
            R C+G + A T + +     +Q F+F+P    ++ LK
Sbjct: 440 PRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLK 477


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,918,744
Number of Sequences: 37866
Number of extensions: 882906
Number of successful extensions: 2198
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 1958
Number of HSP's gapped (non-prelim): 101
length of query: 502
length of database: 18,247,518
effective HSP length: 107
effective length of query: 395
effective length of database: 14,195,856
effective search space: 5607363120
effective search space used: 5607363120
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.