Search of human proteins with 169790923

Search of human proteins with 169790923

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|169790923 5-methyltetrahydrofolate-homocysteine
methyltransferase [Homo sapiens]
         (1265 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|169790923 5-methyltetrahydrofolate-homocysteine methyltransfe...  2536   0.0  
gi|157266337 betaine-homocysteine methyltransferase [Homo sapiens]     56   2e-07
gi|13162290 betaine-homocysteine methyltransferase 2 [Homo sapiens]    51   6e-06
gi|112421122 DnaJ (Hsp40) homolog, subfamily C, member 13 [Homo ...    33   1.3  
gi|8923271 coiled-coil domain containing 49 [Homo sapiens]             33   1.7  
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap...    32   2.9  
gi|83367077 mucin 16 [Homo sapiens]                                    31   8.6  

>gi|169790923 5-methyltetrahydrofolate-homocysteine methyltransferase
            [Homo sapiens]
          Length = 1265

 Score = 2536 bits (6574), Expect = 0.0
 Identities = 1265/1265 (100%), Positives = 1265/1265 (100%)

Query: 1    MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHA 60
            MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHA
Sbjct: 1    MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHA 60

Query: 61   RPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMC 120
            RPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMC
Sbjct: 61   RPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMC 120

Query: 121  SAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA 180
            SAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA
Sbjct: 121  SAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA 180

Query: 181  KGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQT 240
            KGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQT
Sbjct: 181  KGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQT 240

Query: 241  GEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDET 300
            GEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDET
Sbjct: 241  GEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDET 300

Query: 301  PSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGL 360
            PSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGL
Sbjct: 301  PSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGL 360

Query: 361  EPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDG 420
            EPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDG
Sbjct: 361  EPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDG 420

Query: 421  MLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDD 480
            MLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDD
Sbjct: 421  MLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDD 480

Query: 481  FLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNI 540
            FLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNI
Sbjct: 481  FLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNI 540

Query: 541  LTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLY 600
            LTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLY
Sbjct: 541  LTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLY 600

Query: 601  HAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKV 660
            HAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKV
Sbjct: 601  HAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKV 660

Query: 661  IQTDEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVG 720
            IQTDEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVG
Sbjct: 661  IQTDEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVG 720

Query: 721  DLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATV 780
            DLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATV
Sbjct: 721  DLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATV 780

Query: 781  KGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEM 840
            KGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEM
Sbjct: 781  KGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEM 840

Query: 841  IFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDEN 900
            IFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDEN
Sbjct: 841  IFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDEN 900

Query: 901  LKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQV 960
            LKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQV
Sbjct: 901  LKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQV 960

Query: 961  FEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTL 1020
            FEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTL
Sbjct: 961  FEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTL 1020

Query: 1021 ISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYY 1080
            ISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYY
Sbjct: 1021 ISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYY 1080

Query: 1081 CLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEE 1140
            CLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEE
Sbjct: 1081 CLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEE 1140

Query: 1141 LHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTG 1200
            LHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTG
Sbjct: 1141 LHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTG 1200

Query: 1201 IRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPIL 1260
            IRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPIL
Sbjct: 1201 IRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPIL 1260

Query: 1261 GYDTD 1265
            GYDTD
Sbjct: 1261 GYDTD 1265


>gi|157266337 betaine-homocysteine methyltransferase [Homo sapiens]
          Length = 406

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 70/306 (22%), Positives = 132/306 (43%), Gaps = 48/306 (15%)

Query: 71  SITQPDVIYQIHKEYLLAGADIIETNTFSSTSIA---QADYGLEHLA-YRMNMCSAGVAR 126
           ++  P+ + Q+H+E+L AG+++++T TF ++      + +Y LE ++   +N  +  +AR
Sbjct: 49  AVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIAR 108

Query: 127 KAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDG 186
           + A+E          VAG +  T   LS                E+ + + +Q +  +  
Sbjct: 109 QVADEG------DALVAGGVSQTPSYLSCKSET-----------EVKKVFLQQLEVFMKK 151

Query: 187 GVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVI 246
            VD L+ E      + + A++A++ L     + +P+  +   +   G       GE  V 
Sbjct: 152 NVDFLIAEYF---EHVEEAVWAVETLIA---SGKPV-AATMCIGPEGDLHGVPPGECAVR 204

Query: 247 SVSHGEPLCIGLNCALGAAEMRPFIEII-----GKCTTAYVLCYPNA-GLPNT----FGD 296
            V  G  + IG+NC          ++++          A+++  P A   P+     F D
Sbjct: 205 LVKAGASI-IGVNCHFDPTISLKTVKLMKEGLEAARLKAHLMSQPLAYHTPDCNKQGFID 263

Query: 297 YDETPSMMAKH------LKDFAMDGL---VNIVGGCCGSTPDHIREIAEAVKNCKPRVPP 347
             E P  +         ++ +A +     V  +GGCCG  P HIR IAE +   +  +PP
Sbjct: 264 LPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPP 323

Query: 348 ATAFEG 353
           A+   G
Sbjct: 324 ASEKHG 329


>gi|13162290 betaine-homocysteine methyltransferase 2 [Homo sapiens]
          Length = 363

 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 70/302 (23%), Positives = 131/302 (43%), Gaps = 51/302 (16%)

Query: 72  ITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEE 131
           I  PD + Q+H E+L AG+++++T TFS++     +  +E     +N  +  +AR+ A +
Sbjct: 50  IEHPDAVRQLHMEFLRAGSNVMQTFTFSAS-----EDNMESKWEDVNAAACDLAREVAGK 104

Query: 132 VTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDIL 191
                     VAG +  T+         ++ + R      + + +++Q +      VD L
Sbjct: 105 GDA------LVAGGICQTSIY-----KYQKDEAR------IKKLFRQQLEVFAWKNVDFL 147

Query: 192 LIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHG 251
           + E      + + A++A++ L   K + RP+ ++   +   G       GE  V  V  G
Sbjct: 148 IAEYF---EHVEEAVWAVEVL---KESDRPVAVT-MCIGPEGDMHDITPGECAVRLVKAG 200

Query: 252 EPLCIGLNCALGAAEMRPFIEIIGKCTT-----AYVLCYP------NAGLPNTFGDYDET 300
             + +G+NC  G       +E++ +        A+++  P      + G    F D  E 
Sbjct: 201 ASI-VGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPLGFHAPDCGKEG-FVDLPEY 258

Query: 301 PSMMAKH------LKDFAMDGL---VNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAF 351
           P  +         ++ +A +     V  +GGCCG  P HIR IAE +   +  +PPA+  
Sbjct: 259 PFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEK 318

Query: 352 EG 353
            G
Sbjct: 319 HG 320


>gi|112421122 DnaJ (Hsp40) homolog, subfamily C, member 13 [Homo
           sapiens]
          Length = 2243

 Score = 33.5 bits (75), Expect = 1.3
 Identities = 24/86 (27%), Positives = 45/86 (52%), Gaps = 16/86 (18%)

Query: 813 DKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIRIPLLIGGATTSKTHTAV-- 870
           ++I+K+A+DH  + IG+S          + + KE       + L  G  +T ++ T++  
Sbjct: 188 EEIIKSAIDHAGNYIGIS----------LRIRKEPLEFEQYLNLRFGKYSTDESITSLAE 237

Query: 871 ----KIAPRYSAPVIHVLDASKSVVV 892
               KI+PR+S PV  VL  +++ +V
Sbjct: 238 FVVQKISPRHSEPVKRVLALTETCLV 263


>gi|8923271 coiled-coil domain containing 49 [Homo sapiens]
          Length = 425

 Score = 33.1 bits (74), Expect = 1.7
 Identities = 20/58 (34%), Positives = 31/58 (53%), Gaps = 2/58 (3%)

Query: 638 KDPEATEKLLRYAQTQGTGGKKVIQTDEWRNGP--VEERLEYALVKGIEKHIIEDTEE 693
           ++  A E++ RYA+  G   KK  + D    GP  +  R EY L + I+K++ E  EE
Sbjct: 45  REERAREEMQRYAEDVGAVKKKEEKLDWMYQGPGGMVNRDEYLLGRPIDKYVFEKMEE 102


>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
          Length = 1124

 Score = 32.3 bits (72), Expect = 2.9
 Identities = 29/101 (28%), Positives = 49/101 (48%), Gaps = 8/101 (7%)

Query: 1171 IRPAPGYPSQPDHTEKLTMWRLADI--EQSTGIR---LTESLAMAPASAVSGLYFSNLKS 1225
            +R      +Q + +E LT W L+DI   Q   I+   +T S A+   + + G   S++  
Sbjct: 613  VRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITI 672

Query: 1226 KYFAVGKISKDQVEDYALRKNISVAEVE-KWLGPILGYDTD 1265
            +Y   GK ++DQ  D  + KN ++ + + K L P   Y  D
Sbjct: 673  RYKVQGK-NEDQHVDVKI-KNATITQYQLKGLEPETAYQVD 711


>gi|83367077 mucin 16 [Homo sapiens]
          Length = 14507

 Score = 30.8 bits (68), Expect = 8.6
 Identities = 26/99 (26%), Positives = 44/99 (44%), Gaps = 12/99 (12%)

Query: 492   GAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTG----- 546
             G  +  +  +++G AT  D    +C   +HL  K  G N   + ++ + LT G       
Sbjct: 12439 GCRLTSLRSEKDGAATGVDA---ICI--HHLDPKSPGLNRERLYWELSQLTNGIKELGPY 12493

Query: 547   -MEEHNLYAINFIHATKVIKETLPG-ARISGGLSNLSFS 583
              ++ ++LY   F H T V   + PG + +  G S   FS
Sbjct: 12494 TLDRNSLYVNGFTHRTSVPTSSTPGTSTVDLGTSGTPFS 12532


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,876,613
Number of Sequences: 37866
Number of extensions: 2109883
Number of successful extensions: 4481
Number of sequences better than 10.0: 7
Number of HSP's better than 10.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 4465
Number of HSP's gapped (non-prelim): 14
length of query: 1265
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1151
effective length of database: 13,930,794
effective search space: 16034343894
effective search space used: 16034343894
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.