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Search of human proteins with 111378393
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|111378393 sodium channel, voltage-gated, type VII, alpha
[Homo sapiens]
(1682 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|111378393 sodium channel, voltage-gated, type VII, alpha [Hom... 3395 0.0
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi... 1605 0.0
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s... 1403 0.0
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor... 1343 0.0
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor... 1343 0.0
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor... 1343 0.0
gi|126362949 sodium channel, voltage-gated, type III, alpha isof... 1308 0.0
gi|126362955 sodium channel, voltage-gated, type III, alpha isof... 1306 0.0
gi|126362947 sodium channel, voltage-gated, type III, alpha isof... 1306 0.0
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ... 1303 0.0
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo... 1266 0.0
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo... 1163 0.0
gi|237512982 voltage-gated sodium channel type V alpha isoform f... 1139 0.0
gi|30089970 voltage-gated sodium channel type V alpha isoform b ... 1125 0.0
gi|37622907 voltage-gated sodium channel type V alpha isoform a ... 1121 0.0
gi|150417967 voltage-gated sodium channel type V alpha isoform c... 1121 0.0
gi|150417969 voltage-gated sodium channel type V alpha isoform d... 1089 0.0
gi|237512980 voltage-gated sodium channel type V alpha isoform e... 1067 0.0
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ... 1040 0.0
gi|239748090 PREDICTED: similar to sodium channel, voltage-gated... 661 0.0
gi|193794832 calcium channel, voltage-dependent, L type, alpha 1... 408 e-113
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1... 407 e-113
gi|193788540 calcium channel, voltage-dependent, L type, alpha 1... 407 e-113
gi|193788538 calcium channel, voltage-dependent, L type, alpha 1... 407 e-113
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1... 407 e-113
gi|193788532 calcium channel, voltage-dependent, L type, alpha 1... 407 e-113
gi|193794828 calcium channel, voltage-dependent, L type, alpha 1... 407 e-113
gi|193788544 calcium channel, voltage-dependent, L type, alpha 1... 407 e-113
gi|193794830 calcium channel, voltage-dependent, L type, alpha 1... 404 e-112
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1... 404 e-112
>gi|111378393 sodium channel, voltage-gated, type VII, alpha [Homo
sapiens]
Length = 1682
Score = 3395 bits (8802), Expect = 0.0
Identities = 1682/1682 (100%), Positives = 1682/1682 (100%)
Query: 1 MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEEDLKPTPDLEVGKKLPFIYGNLSQG 60
MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEEDLKPTPDLEVGKKLPFIYGNLSQG
Sbjct: 1 MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEEDLKPTPDLEVGKKLPFIYGNLSQG 60
Query: 61 MVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFF 120
MVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFF
Sbjct: 61 MVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFF 120
Query: 121 QLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPW 180
QLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPW
Sbjct: 121 QLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPW 180
Query: 181 NWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGV 240
NWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGV
Sbjct: 181 NWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGV 240
Query: 241 IILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEG 300
IILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEG
Sbjct: 241 IILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEG 300
Query: 301 ERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYH 360
ERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYH
Sbjct: 301 ERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYH 360
Query: 361 QILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGK 420
QILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGK
Sbjct: 361 QILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGK 420
Query: 421 ELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAK 480
ELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAK
Sbjct: 421 ELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAK 480
Query: 481 TFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIG 540
TFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIG
Sbjct: 481 TFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIG 540
Query: 541 NLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRM 600
NLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRM
Sbjct: 541 NLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRM 600
Query: 601 LRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHI 660
LRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHI
Sbjct: 601 LRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHI 660
Query: 661 DKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLV 720
DKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLV
Sbjct: 661 DKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLV 720
Query: 721 LYLFLALVSSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDH 780
LYLFLALVSSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDH
Sbjct: 721 LYLFLALVSSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDH 780
Query: 781 VNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIAS 840
VNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIAS
Sbjct: 781 VNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIAS 840
Query: 841 GESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNG 900
GESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNG
Sbjct: 841 GESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNG 900
Query: 901 CRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQ 960
CRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQ
Sbjct: 901 CRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQ 960
Query: 961 RKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTR 1020
RKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTR
Sbjct: 961 RKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTR 1020
Query: 1021 EELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLF 1080
EELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLF
Sbjct: 1021 EELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLF 1080
Query: 1081 AGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVAT 1140
AGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVAT
Sbjct: 1081 AGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVAT 1140
Query: 1141 FNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHK 1200
FNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHK
Sbjct: 1141 FNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHK 1200
Query: 1201 IKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVL 1260
IKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVL
Sbjct: 1201 IKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVL 1260
Query: 1261 ICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFM 1320
ICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFM
Sbjct: 1261 ICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFM 1320
Query: 1321 VVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPAL 1380
VVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPAL
Sbjct: 1321 VVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPAL 1380
Query: 1381 LNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGML 1440
LNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGML
Sbjct: 1381 LNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGML 1440
Query: 1441 DAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLN 1500
DAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLN
Sbjct: 1441 DAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLN 1500
Query: 1501 IASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLI 1560
IASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLI
Sbjct: 1501 IASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLI 1560
Query: 1561 ALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTL 1620
ALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTL
Sbjct: 1561 ALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTL 1620
Query: 1621 KRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAYFDKAKEKSPIQS 1680
KRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAYFDKAKEKSPIQS
Sbjct: 1621 KRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAYFDKAKEKSPIQS 1680
Query: 1681 QI 1682
QI
Sbjct: 1681 QI 1682
>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
Length = 1836
Score = 1605 bits (4156), Expect = 0.0
Identities = 854/1763 (48%), Positives = 1141/1763 (64%), Gaps = 109/1763 (6%)
Query: 7 PKGLVPFTKESFELIKQH-------IAKTHNEDHEEEDLKPTPDLEVGKKLPFIYGNLSQ 59
P+ L PFT+ES I+Q + + + EE + KP DLE GK LP IYG+
Sbjct: 14 PECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLPMIYGDPPP 73
Query: 60 GMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPF 119
++ PLED+DPYY KK TFIVLNK + IFRF+A L LSPF+ +RR IKVL+H
Sbjct: 74 EVIGIPLEDLDPYYSNKK-TFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVLIHAL 132
Query: 120 FQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDP 179
F +FI+I++L +CVFM++++ P W +E T GIYTFE L+K+ ARG F+FL DP
Sbjct: 133 FSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDP 192
Query: 180 WNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIG 239
WNWLDFSV + + + L I L+T R LR LK I + GLK++VG LI +K+L
Sbjct: 193 WNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSD 252
Query: 240 VIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQE--------NENETLH----------- 280
V+ILT+F LS+F+L+G+ LFMGNL+ KC RWP N+T +
Sbjct: 253 VMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEMW 312
Query: 281 --------NRTGNPY-------------YIRETENFYYLEGERYALLCGNRTDAGQCPEG 319
N T N + YI + NFY+LEG ALLCGN +DAG CPEG
Sbjct: 313 YGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEG 372
Query: 320 YVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSF 379
Y C+K G NP+ G+T++D+F WA ALFRLM QDY E L+ L A+GK YMIFFVV+ F
Sbjct: 373 YECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIF 432
Query: 380 LFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNET-DEAKTIQI-- 436
L SFY+ +L L ++AMAY E+ + K+ E +FQQ ++ ++ E ++AK Q
Sbjct: 433 LGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALE 492
Query: 437 ---------------------EMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYW 475
+ +K +P + + + DA EELE++ + CP +W
Sbjct: 493 GGEADGDPAHGKDCNGSLDTSQGEKGAPRQSSSGDSGISDAM----EELEEAHQKCPPWW 548
Query: 476 YKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNT 535
YK A LIWNC WLK K +H I+M PF DL + ICI+LN F+ +EHYPM++ +
Sbjct: 549 YKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDN 608
Query: 536 LLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALL 595
+L +GNLVF GIFTAEM+ K+IAM PY YFQ GWNIFDS+IV L+EL LANV G+++L
Sbjct: 609 VLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVL 668
Query: 596 RLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEE 655
R FR+LR+FKL K WPT +L+ + NS AL +L L+L +F A GM+LFGK+Y+E
Sbjct: 669 RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKE 728
Query: 656 FVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILI 715
VC I DC LPRWHMHDFFHSFL VFRILCGEW+ET+WDCMEVAGQ+ C+ +LMV++I
Sbjct: 729 CVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVI 788
Query: 716 GNLLVLYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYV---LLKILCKTQ 771
GNL+VL LFLAL+ SSFS+ ++E+ E NLQ+A+ RIK GI + LL +L
Sbjct: 789 GNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAKAFLLGLLHGKI 848
Query: 772 NVPKDTM------------DHVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNAT 819
PKD M E +++ + +L L + G ++
Sbjct: 849 LSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPP-SSL 907
Query: 820 ENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSK---EKIKQSSSSECST 876
E + + I +P ++ VPIAS ESD+E +E + S SK + + +SS CST
Sbjct: 908 ELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCST 967
Query: 877 VDIAISEE------EEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKI 930
D EE EE G + + C + + + +GK W +R+ C KI
Sbjct: 968 ADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKI 1027
Query: 931 VENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAY 990
VE+NWF+ FI + LLS+G LAFEDIY++QR+ I+ +LEYAD +FTYIFI+EMLLKW+AY
Sbjct: 1028 VEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAY 1087
Query: 991 GFKAYFSNGWYRLDFVVVIVFCLSLIGKTR--EELKPLISMKFLR---PLRVLSQFERMK 1045
GFK YF+N W LDF++V V +SL+ EL P+ S++ LR PLR LS+FE M+
Sbjct: 1088 GFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMR 1147
Query: 1046 VVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKS 1105
VVV AL+ +NV LVCL+ WLIFSIMGV+LFAG+FY CI+ T+ ERF SEV NKS
Sbjct: 1148 VVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKS 1207
Query: 1106 RCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEV 1165
CESL+ + W N K+N+DNVG G+LSLLQVATF GW+ IM +A+DS QP +EV
Sbjct: 1208 ECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEV 1267
Query: 1166 NIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLM 1225
N+YMY YF+ FIIFG F L++ I VIIDNFN+ K KLGG +IF+T +Q+K Y +KKL
Sbjct: 1268 NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLG 1327
Query: 1226 YEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYW 1285
+ Q+P+PRP NK+QG ++D+VT QAF++ +M+LIC + MM++TD QS LY
Sbjct: 1328 SKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYN 1387
Query: 1286 INSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLV 1345
IN IF++++T EC+LK++A R +YFT+ WNIFDF+VVI SI GL L + Y V P+L
Sbjct: 1388 INMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLF 1447
Query: 1346 QLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYV 1405
++I L+RI +LRL +G K L+ LM+SLPAL NI LL+FLVMFIY++FGM NFAYV
Sbjct: 1448 RVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYV 1507
Query: 1406 KKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGD 1465
KKE+GI+D+ NFETFGNS++CLF++ AGWDG+L+ I NS DCDP+ NPGT V+GD
Sbjct: 1508 KKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGD 1567
Query: 1466 CGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRF 1525
CGNPS+GI +F SYI+IS+LI+VNMYI +++E N+A+++ ++ L EDDF F++ W++F
Sbjct: 1568 CGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKF 1627
Query: 1526 DPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRV 1585
DPD TQ+I S+LSDF L PL +AKPNK +LI LDLPM GD+IHCLDIL A TK V
Sbjct: 1628 DPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEV 1687
Query: 1586 MGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRND 1645
+G M+ + +E F+ ANP K++ EPITTTLKRK E V A IQRAY+ + L+R+
Sbjct: 1688 LGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSM 1747
Query: 1646 KNTSDI--HMIDGDRDVHATKEG 1666
K S + H DG D KEG
Sbjct: 1748 KQASYMYRHSHDGSGDDAPEKEG 1770
>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
sapiens]
Length = 1977
Score = 1403 bits (3632), Expect = 0.0
Identities = 720/1293 (55%), Positives = 940/1293 (72%), Gaps = 39/1293 (3%)
Query: 422 LQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHK------------EELEKSKK 469
L G E T QI K+R S S D+L D LR + EELE+S++
Sbjct: 639 LPNGQLLPEGTTNQIHKKRRCS-SYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQ 697
Query: 470 ICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPM 529
CP +WY+FA FLIWNCSP W+K K+ ++ I+M PF DL + ICI+LN F+ +EH+PM
Sbjct: 698 KCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPM 757
Query: 530 SKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANV 589
+++ +L IGNLVF GIF AEM+ K+IAM PY YFQVGWNIFDS+IV L+EL LA+V
Sbjct: 758 TEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADV 817
Query: 590 AGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLF 649
G+++LR FR+LR+FKL K WPT +L+ + NS AL +L L+L +F A GM+LF
Sbjct: 818 EGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 877
Query: 650 GKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFY 709
GK+Y+E VC I+ DC LPRWHM+DFFHSFL VFR+LCGEW+ET+WDCMEVAGQ+ C+ Y
Sbjct: 878 GKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVY 937
Query: 710 LMVILIGNLLVLYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYV------ 762
+MV++IGNL+VL LFLAL+ SSFSS EE+ +A NLQ+AV RIKKGINYV
Sbjct: 938 MMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLRE 997
Query: 763 -LLKILCKTQNVPKDTMDHVNEVYVKED-ISDHTLSELSNTQDFLKDKEKSSG----TEK 816
+LK K + ++ + KE+ IS+HTL+E+S +FLK+K+K SG +K
Sbjct: 998 FILKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDK 1057
Query: 817 NATEN-ESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECS 875
+ E+ + QS I +PS++ TVPIA GESD+EN++ +E+ S S SK ++ +SSSSECS
Sbjct: 1058 HLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECS 1117
Query: 876 TVDIAI-----SEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKI 930
TVD + E E E +GC R S Q++ S KGKIW NIRKTC KI
Sbjct: 1118 TVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKI 1177
Query: 931 VENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAY 990
VE++WF+ FI L+ LLS+G LAFEDIY++++KTIKI+LEYAD IFTYIFILEMLLKW+AY
Sbjct: 1178 VEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAY 1237
Query: 991 GFKAYFSNGWYRLDFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERMK 1045
G+K YF+N W LDF++V V ++L+ T +K L +++ LRPLR LS+FE M+
Sbjct: 1238 GYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMR 1297
Query: 1046 VVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKS 1105
VVV ALI +NV LVCL+ WLIFSIMGV+LFAG+FYECI+ T G RFP+S+V N+S
Sbjct: 1298 VVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRS 1357
Query: 1106 RCESLL-FNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFE 1164
C +L+ ++++ W+N K+NFDNVG G+LSLLQVATF GW IM +A+DSV V+ QP +E
Sbjct: 1358 ECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYE 1417
Query: 1165 VNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKL 1224
++YMY YF+ FIIFG F L++ I VIIDNFN+ K KLGG +IF+T +Q+K Y +KKL
Sbjct: 1418 YSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKL 1477
Query: 1225 MYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALY 1284
+ Q+P+PRP NK+QG IFD+VT+QAF++ +MVLIC + MM++ + QS M+ LY
Sbjct: 1478 GSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLY 1537
Query: 1285 WINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSL 1344
WIN +F++L+T EC+LKLI+ R +YFT+ WNIFDF+VVI SI G+ L + +Y V P+L
Sbjct: 1538 WINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTL 1597
Query: 1345 VQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAY 1404
++I L+RI +LRL KG K L+ LM+SLPAL NI LL+FLVMFIYA+FGM NFAY
Sbjct: 1598 FRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAY 1657
Query: 1405 VKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRG 1464
VKKE GIND+ NFETFGNSM+CLFQ+ AGWDG+L I NSK DCDP K++PG+ V G
Sbjct: 1658 VKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEG 1717
Query: 1465 DCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKR 1524
DCGNPSVGIFYFVSYI+IS+L++VNMYI V++E ++A+++ + LSEDDF F++VW++
Sbjct: 1718 DCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEK 1777
Query: 1525 FDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKR 1584
FDPD TQ+I+ SKLSDFAAALDPPL +AKPNK QLIA+DLPM GDRIHCLDIL AFTKR
Sbjct: 1778 FDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKR 1837
Query: 1585 VMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRN 1644
V+G+ M+ + S++E F+ ANP K++ EPITTTLKRKQE VSAT+IQRAY+ YRLR+N
Sbjct: 1838 VLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQN 1897
Query: 1645 DKNTSDIHMIDGDRDVH-ATKEGAYFDKAKEKS 1676
KN S I++ DGDRD K+ FD E S
Sbjct: 1898 VKNISSIYIKDGDRDDDLLNKKDMAFDNVNENS 1930
Score = 449 bits (1154), Expect = e-125
Identities = 247/478 (51%), Positives = 316/478 (66%), Gaps = 14/478 (2%)
Query: 1 MLASPEPKGLVPFTKESFELIKQHIA-------KTHNEDHEEEDLKPTPDLEVGKKLPFI 53
ML P P+ V FTK+S LI+Q IA K +D +EE KP+ DLE GK+LPFI
Sbjct: 3 MLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPFI 62
Query: 54 YGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIK 113
YG++ GMVSEPLED+DPYY KK TFIVLNK +TIFRFNA L LSPF+ +RR +IK
Sbjct: 63 YGDIPPGMVSEPLEDLDPYYADKK-TFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIK 121
Query: 114 VLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSF 173
+LVH F + I+ ++L +C+FM++ N P W +E T GIYTFE LVK+ ARG G F
Sbjct: 122 ILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEF 181
Query: 174 SFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHC 233
+FL DPWNWLDF V VF + + L + L+T R LR LK I + GLK++VG LI
Sbjct: 182 TFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 241
Query: 234 LKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRE-- 291
+K+L V+ILT+F LS+F+LIG+ LFMGNLKHKCFR EN NETL + N E
Sbjct: 242 VKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLEN-NETLES-IMNTLESEEDF 299
Query: 292 TENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMA 351
+ FYYLEG + ALLCG TD+GQCPEGY CVK G NPD G+T+FD+F WA ALFRLM
Sbjct: 300 RKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMT 359
Query: 352 QDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKI 411
QDY E LY Q L A+GK YMIFFVVV FL SFY+ +L L ++AMAYEE+ Q E +K+
Sbjct: 360 QDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQK 419
Query: 412 EPKFQQTGKELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKK 469
E +FQQ L++ E +EA+ I + + I + + E ++ K + +K+
Sbjct: 420 ELEFQQMLDRLKK--EQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKE 475
Score = 135 bits (341), Expect = 3e-31
Identities = 140/577 (24%), Positives = 249/577 (43%), Gaps = 125/577 (21%)
Query: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG----IYTFEILVK 162
IR+T K++ H +F+ FI++ +L+ ++ ++ R +L I+T+ +++
Sbjct: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILE 1229
Query: 163 LFARGVWAGSFSFLGDPWNWLDFS------VTVFEVIIRYSPLDFIPTLQTARTLRILKI 216
+ + + G ++ + W WLDF VT+ + YS L I +L+T R LR L+
Sbjct: 1230 MLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRA 1289
Query: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN 276
+ +G++ +V LI + ++ V+++ L F IFS++G+ LF G ++C
Sbjct: 1290 LSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YEC--------- 1339
Query: 277 ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGF--- 333
I T+ G+R A Q P C A +N Q
Sbjct: 1340 ------------INTTD--------------GSRFPASQVPNRSECF-ALMNVSQNVRWK 1372
Query: 334 ---TNFDSFGWALFALFRLMA-QDYPEVLY---------HQILYASGKVYMIFFVVVSFL 380
NFD+ G +L ++ + + ++Y Q Y I+FVV
Sbjct: 1373 NLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIF 1432
Query: 381 FSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKK 440
SF+ +LF+G++ + ++K+++G Q+ T+E K MKK
Sbjct: 1433 GSFFTLNLFIGVIIDNFNQQKKKLGG----------------QDIFMTEEQKKYYNAMKK 1476
Query: 441 RSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHR 500
+K +K P K I C +
Sbjct: 1477 LGS---------------------KKPQKPIPRPGNK------IQGC----------IFD 1499
Query: 501 IIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMH 560
++ D+ +++ I LN+ + +E S+ +L N+VFI +FT E + K+I++
Sbjct: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR 1559
Query: 561 PYGYFQVGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPT 612
Y YF VGWNIFD ++V ++ + LA++ ++RL R+ RI +L K
Sbjct: 1560 HY-YFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKG 1618
Query: 613 FQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLF 649
+ L+++L S AL ++ LLLF +F A FGM F
Sbjct: 1619 IRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF 1655
Score = 58.2 bits (139), Expect = 7e-08
Identities = 107/502 (21%), Positives = 208/502 (41%), Gaps = 92/502 (18%)
Query: 401 KQRVGEISKKI-EPKFQQTGKELQEGNETDEAKTIQIEMKKRSP-----ISTDTSLDVLE 454
KQ + I ++I E K ++ +E ++ +E + +E K+ P I + LE
Sbjct: 17 KQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPFIYGDIPPGMVSEPLE 76
Query: 455 DATLRHKEE-----LEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDL 509
D + ++ L K K I ++F T ++ SP + L+ +I++ +
Sbjct: 77 DLDPYYADKKTFIVLNKGKTI-----FRFNATPALYMLSP-FSPLRRISIKILVHSLFSM 130
Query: 510 FLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIA----MHPYGYF 565
++ I+ N F+T+ + P + N+ F GI+T E + KI+A + + +
Sbjct: 131 LIMCTILTNCIFMTMNNPP-----DWTKNV-EYTFTGIYTFESLVKILARGFCVGEFTFL 184
Query: 566 QVGWNIFD-SMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSW 624
+ WN D +IVF L E N+ ++ LR FR+LR K P + ++ +L S
Sbjct: 185 RDPWNWLDFVVIVFAYLTE--FVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSV 242
Query: 625 VALKDLVLLLFTFIFFSAAFGMKLFGKNY-------------------------EEF--- 656
L D+++L + A G++LF N E+F
Sbjct: 243 KKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKY 302
Query: 657 -----------VCHIDKDC-QLPRWHM-------HDFFHSFLNVF--------RILCGEW 689
+C D Q P + D+ ++ + F R++ ++
Sbjct: 303 FYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDY 362
Query: 690 VETLW-DCMEVAGQSWCIPFYLMVILIGNLLVLYLFLALVS-SFSSCKDVTAEENNEAK- 746
E L+ + AG+++ I F+++VI +G+ ++ L LA+V+ ++ EE + +
Sbjct: 363 WENLYQQTLRAAGKTYMI-FFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKEL 421
Query: 747 NLQLAVARIKKGIN--YVLLKILCKTQNVPKDTMDHVNEVYVK-EDISDHTLSELSNTQD 803
Q + R+KK + + ++ + + ++E + +S + E N +
Sbjct: 422 EFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRRK 481
Query: 804 FLKDKEKSSGTEKNATENESQS 825
K+ SSG EK E S+S
Sbjct: 482 KKNQKKLSSGEEKGDAEKLSKS 503
Score = 51.6 bits (122), Expect = 6e-06
Identities = 63/295 (21%), Positives = 115/295 (38%), Gaps = 45/295 (15%)
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
+R+ KI+ ++ F I + T+L+ + D K + EY FT I+ E
Sbjct: 115 LRRISIKILVHSLFSMLI-MCTILTNCIFMTMNNPPDWTKNV----EYT---FTGIYTFE 166
Query: 983 MLLKWMAYGFKA----YFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038
L+K +A GF + + W LDFVV IVF + L + + LR L+ +
Sbjct: 167 SLVKILARGFCVGEFTFLRDPWNWLDFVV-IVFAYLTEFVNLGNVSALRTFRVLRALKTI 225
Query: 1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRF-YECIDPTSGERFP 1097
S +K +V ALI++ +V ++ + +F+++G+ LF G ++C +
Sbjct: 226 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNET 285
Query: 1098 SSEVMNKSRCESLLFNESMLWENAK-------------------------------MNFD 1126
+MN E E +K +FD
Sbjct: 286 LESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFD 345
Query: 1127 NVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGV 1181
FL+L ++ T + W + + + F V I++ +++ +I V
Sbjct: 346 TFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAV 400
Score = 47.8 bits (112), Expect = 9e-05
Identities = 44/205 (21%), Positives = 96/205 (46%), Gaps = 26/205 (12%)
Query: 62 VSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQ 121
+ E + P++Y+ + F++ N + +F CI +++ PF
Sbjct: 692 LEESRQKCPPWWYRFAHKFLIWNCSPYWIKFK-----------KCI----YFIVMDPFVD 736
Query: 122 LFILISVLIDCVFMSLTNLP---KWRPVL---ENTLLGIYTFEILVKLFARGVWAGSFSF 175
L I I ++++ +FM++ + P +++ VL GI+ E+++KL A + +
Sbjct: 737 LAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMD----PYEY 792
Query: 176 LGDPWNWLD-FSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCL 234
WN D VT+ V + + ++ + L++ R LR+ K+ L L+ ++ + +
Sbjct: 793 FQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSV 852
Query: 235 KQLIGVIILTLFFLSIFSLIGMGLF 259
L + ++ + IF+++GM LF
Sbjct: 853 GALGNLTLVLAIIVFIFAVVGMQLF 877
Score = 38.5 bits (88), Expect = 0.056
Identities = 42/198 (21%), Positives = 87/198 (43%), Gaps = 27/198 (13%)
Query: 1236 PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSI---FVM 1292
P + L+ ++ F++++M I I M ++ W ++ F
Sbjct: 111 PFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPD---------WTKNVEYTFTG 161
Query: 1293 LYTMECILKLIA--FRCFYFTIA---WNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQL 1347
+YT E ++K++A F FT WN DF+V++F+ +T L S ++
Sbjct: 162 IYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAY------LTEFVNLGNVSALRT 215
Query: 1348 ILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF-AYVK 1406
+ R + + + G K ++ L+ S+ L ++++L + ++A+ G+ F +K
Sbjct: 216 FRVLRALKTISVIPGLK---TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLK 272
Query: 1407 KEAGINDVSNFETFGNSM 1424
+ N + N ET + M
Sbjct: 273 HKCFRNSLENNETLESIM 290
>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
[Homo sapiens]
Length = 2005
Score = 1343 bits (3475), Expect = 0.0
Identities = 695/1292 (53%), Positives = 906/1292 (70%), Gaps = 40/1292 (3%)
Query: 425 GNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHK------------EELEKSKKICP 472
G E T + E++KR S S+D+LED T R + EELE+S++ CP
Sbjct: 667 GQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCP 726
Query: 473 LYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQ 532
WYKFA LIW+C WLK+K V+ ++M PF DL + ICI+LN F+ +EHYPM++Q
Sbjct: 727 PCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQ 786
Query: 533 TNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGM 592
+++L++GNLVF GIFTAEM KIIAM PY YFQ GWNIFD IV L+EL LANV G+
Sbjct: 787 FSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGL 846
Query: 593 ALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
++LR FR+LR+FKL K WPT +L+ + NS AL +L L+L +F A GM+LFGK+
Sbjct: 847 SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS 906
Query: 653 YEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMV 712
Y+E VC I DC+LPRWHMHDFFHSFL VFR+LCGEW+ET+WDCMEVAGQ+ C+ ++MV
Sbjct: 907 YKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMV 966
Query: 713 ILIGNLLVLYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQ 771
++IGNL+VL LFLAL+ SSFSS +++NE NLQ+AV R++KGI++V KI Q
Sbjct: 967 MVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQ 1026
Query: 772 NVPKDTMDHVNEVYVKED--------ISDHTLSELSNTQDFLKDKEKS-----SGTEKNA 818
++E+ ED IS+HT E+ ++LKD + S EK
Sbjct: 1027 KAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYV 1086
Query: 819 T-ENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTV 877
E++ S I +PS++ TVPIA GESD ENL+ +E S+S SKEK+ +SSSE STV
Sbjct: 1087 VDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTV 1146
Query: 878 DI-AISEEEEMFYGGERSKH----LKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVE 932
DI A +E E+ E S C R QIS KGK+W N+RKTC KIVE
Sbjct: 1147 DIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVE 1206
Query: 933 NNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGF 992
+NWF+ FI + LLS+G LAFEDIY++QRKTIK +LEYAD +FTYIFILEMLLKW+AYGF
Sbjct: 1207 HNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF 1266
Query: 993 KAYFSNGWYRLDFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERMKVV 1047
+ YF+N W LDF++V V +SL +K L +++ LRPLR LS+FE M+VV
Sbjct: 1267 QVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVV 1326
Query: 1048 VRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRC 1107
V AL+ +NV LVCL+ WLIFSIMGV+LFAG+FY CI+ T+GE F S V N S C
Sbjct: 1327 VNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSEC 1386
Query: 1108 ESLL-FNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVN 1166
++L+ N++ W+N K+NFDNVG G+LSLLQVATF GW+ IM +A+DS V +QP +E N
Sbjct: 1387 KALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDN 1446
Query: 1167 IYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMY 1226
+YMY YF+ FIIFG F L++ I VIIDNFN+ K K GG +IF+T +Q+K Y +KKL
Sbjct: 1447 LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1506
Query: 1227 EDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWI 1286
+ Q+P+PRP NK QG +FD VT Q F++ +M+LIC + MM++TD QS +M+ LYWI
Sbjct: 1507 KKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWI 1566
Query: 1287 NSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQ 1346
N +F++L+T EC+LKLI+ R +YFTI WNIFDF+VVI SI G+ L + Y V P+L +
Sbjct: 1567 NLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFR 1626
Query: 1347 LILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVK 1406
+I L+RI +LRL KG K L+ LM+SLPAL NI LL+FLVMFIYA+FGM NFAYVK
Sbjct: 1627 VIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK 1686
Query: 1407 KEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDC 1466
+E GI+D+ NFETFGNSM+CLFQ+ AGWDG+L I NS DCDPDK +PG+ V+GDC
Sbjct: 1687 REVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDC 1746
Query: 1467 GNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFD 1526
GNPSVGIF+FVSYI+IS+L++VNMYI V++E ++A+++ + LSEDDF F++VW++FD
Sbjct: 1747 GNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFD 1806
Query: 1527 PDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVM 1586
PD TQ+I+ +KLSDFA ALDPPL +AKPNK QLIA+DLPM GDRIHCLDIL AFTKRV+
Sbjct: 1807 PDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVL 1866
Query: 1587 GQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDK 1646
G+ M+ + ++E F+ +NP K++ EPITTTLKRKQE VSA IIQRAY+ Y L++ K
Sbjct: 1867 GESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVK 1926
Query: 1647 NTSDIHMIDGDRDVHAT--KEGAYFDKAKEKS 1676
S I+ D ++ T KE DK E S
Sbjct: 1927 KVSSIYKKDKGKECDGTPIKEDTLIDKLNENS 1958
Score = 422 bits (1085), Expect = e-117
Identities = 224/469 (47%), Positives = 301/469 (64%), Gaps = 29/469 (6%)
Query: 1 MLASPEPKGLVPFTKESFELIKQHIA-------KTHNEDHEEED-LKPTPDLEVGKKLPF 52
+L P P FT+ES I+Q IA K +D ++E+ KP DLE GK LPF
Sbjct: 5 VLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPF 64
Query: 53 IYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTI 112
IYG++ MVS PLED+DPYY KK TFIVLNK + I RF+A L L+PFN IR+ I
Sbjct: 65 IYGDIPPEMVSVPLEDLDPYYINKK-TFIVLNKGKAISRFSATPALYILTPFNPIRKLAI 123
Query: 113 KVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGS 172
K+LVH F + I+ ++L +CVFM+++N P W +E T GIYTFE L+K+ ARG
Sbjct: 124 KILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 183
Query: 173 FSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIH 232
F+FL DPWNWLDF+V F + + L + L+T R LR LK I + GLK++VG LI
Sbjct: 184 FTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243
Query: 233 CLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENE----------------N 276
+K+L V+ILT+F LS+F+LIG+ LFMGNL++KC +WP +N N
Sbjct: 244 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303
Query: 277 ETLHNRTGNPY----YIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQG 332
T NRT + + YI + +FY+LEG+ ALLCGN +DAGQCPEGY+CVKAG NP+ G
Sbjct: 304 GTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYG 363
Query: 333 FTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGI 392
+T+FD+F WA +LFRLM QD+ E LY L A+GK YMIFFV+V FL SFY+ +L L +
Sbjct: 364 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAV 423
Query: 393 LAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKR 441
+AMAYEE+ Q E +++ E +FQQ ++L++ E +A + R
Sbjct: 424 VAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
Score = 144 bits (362), Expect = 9e-34
Identities = 154/688 (22%), Positives = 294/688 (42%), Gaps = 142/688 (20%)
Query: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG----IYTFEILVK 162
+R+T K++ H +F+ FI+ +L+ ++ ++ + T+L ++T+ +++
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
Query: 163 LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216
+ + V G + + W WLDF + ++ + YS L I +L+T R LR L+
Sbjct: 1257 MLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRA 1316
Query: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN 276
+ +G++ +V L+ + ++ V+++ L F IFS++G+ LF G H
Sbjct: 1317 LSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH----------- 1365
Query: 277 ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNF 336
++ TG + + N+ E AL+ N+T + + NF
Sbjct: 1366 -CINYTTGEMFDVSVVNNY----SECKALIESNQTARWKNVK---------------VNF 1405
Query: 337 DSFGWALFALFRLMA-QDYPEVLYH---------QILYASGKVYMIFFVVVSFLFSFYMA 386
D+ G +L ++ + + +++Y Q Y ++FV+ SF+
Sbjct: 1406 DNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTL 1465
Query: 387 SLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPIST 446
+LF+G++ + ++K++ G Q+ T+E K MKK
Sbjct: 1466 NLFIGVIIDNFNQQKKKFGG----------------QDIFMTEEQKKYYNAMKKLGS--- 1506
Query: 447 DTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPF 506
+K +K P KF + V +
Sbjct: 1507 ------------------KKPQKPIPRPANKF----------------QGMVFDFVTKQV 1532
Query: 507 TDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQ 566
D+ ++I I LN+ + +E S++ +L NLVFI +FT E + K+I++ Y YF
Sbjct: 1533 FDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLR-YYYFT 1591
Query: 567 VGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQILMW 618
+GWNIFD ++V ++ + LA + ++RL R+ RI +L K + L++
Sbjct: 1592 IGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1651
Query: 619 SLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSF 678
+L S AL ++ LLLF +F A FGM F Y + ID ++ F +S
Sbjct: 1652 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--YVKREVGID-----DMFNFETFGNSM 1704
Query: 679 LNVFRILCGEWVETLWDCMEVAGQSWCIP---------------------FYLMVILIGN 717
+ +F+I + L + +G C P F++ I+I
Sbjct: 1705 ICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISF 1764
Query: 718 LLVLYLFLALV-SSFSSCKDVTAEENNE 744
L+V+ +++A++ +FS + +AE +E
Sbjct: 1765 LVVVNMYIAVILENFSVATEESAEPLSE 1792
Score = 53.5 bits (127), Expect = 2e-06
Identities = 59/263 (22%), Positives = 120/263 (45%), Gaps = 26/263 (9%)
Query: 401 KQRVGEISKKIEPKFQQTGKELQEG----NETDEAKTIQIEMKKRSPISTDTSLDVLEDA 456
+QR+ E K PK ++ ++ + G ++ + K++ P L+ L+
Sbjct: 26 EQRIAEEKAK-RPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSVPLEDLDPY 84
Query: 457 TLRHKE--ELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIIC 514
+ K L K K I +F+ T ++ +P + +++ +I++ ++ ++
Sbjct: 85 YINKKTFIVLNKGKAIS-----RFSATPALYILTP-FNPIRKLAIKILVHSLFNMLIMCT 138
Query: 515 IILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIA----MHPYGYFQVGWN 570
I+ N F+T+ + P + N+ F GI+T E + KI+A + + + + WN
Sbjct: 139 ILTNCVFMTMSNPP-----DWTKNV-EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWN 192
Query: 571 IFD-SMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKD 629
D ++I F + E N+ ++ LR FR+LR K P + ++ +L S L D
Sbjct: 193 WLDFTVITFAYVTE--FVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSD 250
Query: 630 LVLLLFTFIFFSAAFGMKLFGKN 652
+++L + A G++LF N
Sbjct: 251 VMILTVFCLSVFALIGLQLFMGN 273
Score = 49.7 bits (117), Expect = 2e-05
Identities = 45/164 (27%), Positives = 75/164 (45%), Gaps = 13/164 (7%)
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
IRK KI+ ++ F I + T+L+ D K + EY FT I+ E
Sbjct: 118 IRKLAIKILVHSLFNMLI-MCTILTNCVFMTMSNPPDWTKNV----EYT---FTGIYTFE 169
Query: 983 MLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038
L+K +A GF + + W LDF V I F + L + + LR L+ +
Sbjct: 170 SLIKILARGFCLEDFTFLRDPWNWLDFTV-ITFAYVTEFVNLGNVSALRTFRVLRALKTI 228
Query: 1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG 1082
S +K +V ALI++ +V ++ + +F+++G+ LF G
Sbjct: 229 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
Score = 48.5 bits (114), Expect = 5e-05
Identities = 38/164 (23%), Positives = 84/164 (51%), Gaps = 11/164 (6%)
Query: 103 PFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLP---KWRPVLENTLL---GIYT 156
P+ ++ V++ PF L I I ++++ +FM++ + P ++ VL L GI+T
Sbjct: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803
Query: 157 FEILVKLFARGVWAGSFSFLGDPWNWLD-FSVTVFEVIIRYSPLDFIPTLQTARTLRILK 215
E+ +K+ A + + + WN D F V++ + + + ++ + L++ R LR+ K
Sbjct: 804 AEMFLKIIAMD----PYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859
Query: 216 IIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLF 259
+ L L+ ++ + + L + ++ + IF+++GM LF
Sbjct: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 903
Score = 40.4 bits (93), Expect = 0.015
Identities = 44/170 (25%), Positives = 78/170 (45%), Gaps = 29/170 (17%)
Query: 674 FFHSFLNVFRILCGEWVETLWDC-MEVAGQSWCIPFYLMVILIGNLLVLYLFLALVSSFS 732
F +FL++FR++ ++ E L+ + AG+++ I F+++VI +G+ ++ L LA+V+
Sbjct: 370 FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMI-FFVLVIFLGSFYLINLILAVVA--- 425
Query: 733 SCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQN--------VPKDTMD----- 779
+ EE N+A L A K+ +L+ L K Q ++ D
Sbjct: 426 ----MAYEEQNQA---TLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAG 478
Query: 780 ----HVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQS 825
V +S + EL N + K KE+S EKN +S+S
Sbjct: 479 GIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSES 528
Score = 36.2 bits (82), Expect = 0.28
Identities = 36/175 (20%), Positives = 71/175 (40%), Gaps = 26/175 (14%)
Query: 1236 PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSI---FVM 1292
P N ++ ++ FN+++M I + M MS W ++ F
Sbjct: 114 PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFM---------TMSNPPDWTKNVEYTFTG 164
Query: 1293 LYTMECILKLIA--FRCFYFTI---AWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQL 1347
+YT E ++K++A F FT WN DF V+ F+ + V V
Sbjct: 165 IYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV---------TEFVNLGNVSA 215
Query: 1348 ILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF 1402
+ R++ L+ ++ L+ S+ L ++++L + ++A+ G+ F
Sbjct: 216 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 1343 bits (3475), Expect = 0.0
Identities = 695/1292 (53%), Positives = 906/1292 (70%), Gaps = 40/1292 (3%)
Query: 425 GNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHK------------EELEKSKKICP 472
G E T + E++KR S S+D+LED T R + EELE+S++ CP
Sbjct: 667 GQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCP 726
Query: 473 LYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQ 532
WYKFA LIW+C WLK+K V+ ++M PF DL + ICI+LN F+ +EHYPM++Q
Sbjct: 727 PCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQ 786
Query: 533 TNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGM 592
+++L++GNLVF GIFTAEM KIIAM PY YFQ GWNIFD IV L+EL LANV G+
Sbjct: 787 FSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGL 846
Query: 593 ALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
++LR FR+LR+FKL K WPT +L+ + NS AL +L L+L +F A GM+LFGK+
Sbjct: 847 SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS 906
Query: 653 YEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMV 712
Y+E VC I DC+LPRWHMHDFFHSFL VFR+LCGEW+ET+WDCMEVAGQ+ C+ ++MV
Sbjct: 907 YKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMV 966
Query: 713 ILIGNLLVLYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQ 771
++IGNL+VL LFLAL+ SSFSS +++NE NLQ+AV R++KGI++V KI Q
Sbjct: 967 MVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQ 1026
Query: 772 NVPKDTMDHVNEVYVKED--------ISDHTLSELSNTQDFLKDKEKS-----SGTEKNA 818
++E+ ED IS+HT E+ ++LKD + S EK
Sbjct: 1027 KAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYV 1086
Query: 819 T-ENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTV 877
E++ S I +PS++ TVPIA GESD ENL+ +E S+S SKEK+ +SSSE STV
Sbjct: 1087 VDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTV 1146
Query: 878 DI-AISEEEEMFYGGERSKH----LKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVE 932
DI A +E E+ E S C R QIS KGK+W N+RKTC KIVE
Sbjct: 1147 DIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVE 1206
Query: 933 NNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGF 992
+NWF+ FI + LLS+G LAFEDIY++QRKTIK +LEYAD +FTYIFILEMLLKW+AYGF
Sbjct: 1207 HNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF 1266
Query: 993 KAYFSNGWYRLDFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERMKVV 1047
+ YF+N W LDF++V V +SL +K L +++ LRPLR LS+FE M+VV
Sbjct: 1267 QVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVV 1326
Query: 1048 VRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRC 1107
V AL+ +NV LVCL+ WLIFSIMGV+LFAG+FY CI+ T+GE F S V N S C
Sbjct: 1327 VNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSEC 1386
Query: 1108 ESLL-FNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVN 1166
++L+ N++ W+N K+NFDNVG G+LSLLQVATF GW+ IM +A+DS V +QP +E N
Sbjct: 1387 KALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDN 1446
Query: 1167 IYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMY 1226
+YMY YF+ FIIFG F L++ I VIIDNFN+ K K GG +IF+T +Q+K Y +KKL
Sbjct: 1447 LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1506
Query: 1227 EDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWI 1286
+ Q+P+PRP NK QG +FD VT Q F++ +M+LIC + MM++TD QS +M+ LYWI
Sbjct: 1507 KKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWI 1566
Query: 1287 NSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQ 1346
N +F++L+T EC+LKLI+ R +YFTI WNIFDF+VVI SI G+ L + Y V P+L +
Sbjct: 1567 NLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFR 1626
Query: 1347 LILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVK 1406
+I L+RI +LRL KG K L+ LM+SLPAL NI LL+FLVMFIYA+FGM NFAYVK
Sbjct: 1627 VIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK 1686
Query: 1407 KEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDC 1466
+E GI+D+ NFETFGNSM+CLFQ+ AGWDG+L I NS DCDPDK +PG+ V+GDC
Sbjct: 1687 REVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDC 1746
Query: 1467 GNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFD 1526
GNPSVGIF+FVSYI+IS+L++VNMYI V++E ++A+++ + LSEDDF F++VW++FD
Sbjct: 1747 GNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFD 1806
Query: 1527 PDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVM 1586
PD TQ+I+ +KLSDFA ALDPPL +AKPNK QLIA+DLPM GDRIHCLDIL AFTKRV+
Sbjct: 1807 PDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVL 1866
Query: 1587 GQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDK 1646
G+ M+ + ++E F+ +NP K++ EPITTTLKRKQE VSA IIQRAY+ Y L++ K
Sbjct: 1867 GESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVK 1926
Query: 1647 NTSDIHMIDGDRDVHAT--KEGAYFDKAKEKS 1676
S I+ D ++ T KE DK E S
Sbjct: 1927 KVSSIYKKDKGKECDGTPIKEDTLIDKLNENS 1958
Score = 422 bits (1086), Expect = e-117
Identities = 224/469 (47%), Positives = 301/469 (64%), Gaps = 29/469 (6%)
Query: 1 MLASPEPKGLVPFTKESFELIKQHIA-------KTHNEDHEEED-LKPTPDLEVGKKLPF 52
+L P P FT+ES I+Q IA K +D ++E+ KP DLE GK LPF
Sbjct: 5 VLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPF 64
Query: 53 IYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTI 112
IYG++ MVS PLED+DPYY KK TFIVLNK + I RF+A L L+PFN IR+ I
Sbjct: 65 IYGDIPPEMVSVPLEDLDPYYINKK-TFIVLNKGKAISRFSATPALYILTPFNPIRKLAI 123
Query: 113 KVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGS 172
K+LVH F + I+ ++L +CVFM+++N P W +E T GIYTFE L+K+ ARG
Sbjct: 124 KILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 183
Query: 173 FSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIH 232
F+FL DPWNWLDF+V F + + L + L+T R LR LK I + GLK++VG LI
Sbjct: 184 FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243
Query: 233 CLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENE----------------N 276
+K+L V+ILT+F LS+F+LIG+ LFMGNL++KC +WP +N N
Sbjct: 244 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303
Query: 277 ETLHNRTGNPY----YIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQG 332
T NRT + + YI + +FY+LEG+ ALLCGN +DAGQCPEGY+CVKAG NP+ G
Sbjct: 304 GTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYG 363
Query: 333 FTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGI 392
+T+FD+F WA +LFRLM QD+ E LY L A+GK YMIFFV+V FL SFY+ +L L +
Sbjct: 364 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAV 423
Query: 393 LAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKR 441
+AMAYEE+ Q E +++ E +FQQ ++L++ E +A + R
Sbjct: 424 VAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
Score = 144 bits (362), Expect = 9e-34
Identities = 154/688 (22%), Positives = 294/688 (42%), Gaps = 142/688 (20%)
Query: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG----IYTFEILVK 162
+R+T K++ H +F+ FI+ +L+ ++ ++ + T+L ++T+ +++
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
Query: 163 LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216
+ + V G + + W WLDF + ++ + YS L I +L+T R LR L+
Sbjct: 1257 MLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRA 1316
Query: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN 276
+ +G++ +V L+ + ++ V+++ L F IFS++G+ LF G H
Sbjct: 1317 LSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH----------- 1365
Query: 277 ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNF 336
++ TG + + N+ E AL+ N+T + + NF
Sbjct: 1366 -CINYTTGEMFDVSVVNNY----SECKALIESNQTARWKNVK---------------VNF 1405
Query: 337 DSFGWALFALFRLMA-QDYPEVLYH---------QILYASGKVYMIFFVVVSFLFSFYMA 386
D+ G +L ++ + + +++Y Q Y ++FV+ SF+
Sbjct: 1406 DNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTL 1465
Query: 387 SLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPIST 446
+LF+G++ + ++K++ G Q+ T+E K MKK
Sbjct: 1466 NLFIGVIIDNFNQQKKKFGG----------------QDIFMTEEQKKYYNAMKKLGS--- 1506
Query: 447 DTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPF 506
+K +K P KF + V +
Sbjct: 1507 ------------------KKPQKPIPRPANKF----------------QGMVFDFVTKQV 1532
Query: 507 TDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQ 566
D+ ++I I LN+ + +E S++ +L NLVFI +FT E + K+I++ Y YF
Sbjct: 1533 FDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLR-YYYFT 1591
Query: 567 VGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQILMW 618
+GWNIFD ++V ++ + LA + ++RL R+ RI +L K + L++
Sbjct: 1592 IGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1651
Query: 619 SLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSF 678
+L S AL ++ LLLF +F A FGM F Y + ID ++ F +S
Sbjct: 1652 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--YVKREVGID-----DMFNFETFGNSM 1704
Query: 679 LNVFRILCGEWVETLWDCMEVAGQSWCIP---------------------FYLMVILIGN 717
+ +F+I + L + +G C P F++ I+I
Sbjct: 1705 ICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISF 1764
Query: 718 LLVLYLFLALV-SSFSSCKDVTAEENNE 744
L+V+ +++A++ +FS + +AE +E
Sbjct: 1765 LVVVNMYIAVILENFSVATEESAEPLSE 1792
Score = 51.6 bits (122), Expect = 6e-06
Identities = 58/263 (22%), Positives = 120/263 (45%), Gaps = 26/263 (9%)
Query: 401 KQRVGEISKKIEPKFQQTGKELQEG----NETDEAKTIQIEMKKRSPISTDTSLDVLEDA 456
+QR+ E K PK ++ ++ + G ++ + K++ P L+ L+
Sbjct: 26 EQRIAEEKAK-RPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSVPLEDLDPY 84
Query: 457 TLRHKE--ELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIIC 514
+ K L K K I +F+ T ++ +P + +++ +I++ ++ ++
Sbjct: 85 YINKKTFIVLNKGKAIS-----RFSATPALYILTP-FNPIRKLAIKILVHSLFNMLIMCT 138
Query: 515 IILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIA----MHPYGYFQVGWN 570
I+ N F+T+ + P + N+ F GI+T E + KI+A + + + + WN
Sbjct: 139 ILTNCVFMTMSNPP-----DWTKNV-EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWN 192
Query: 571 IFD-SMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKD 629
D ++I F + E ++ ++ LR FR+LR K P + ++ +L S L D
Sbjct: 193 WLDFTVITFAYVTE--FVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSD 250
Query: 630 LVLLLFTFIFFSAAFGMKLFGKN 652
+++L + A G++LF N
Sbjct: 251 VMILTVFCLSVFALIGLQLFMGN 273
Score = 49.3 bits (116), Expect = 3e-05
Identities = 45/164 (27%), Positives = 75/164 (45%), Gaps = 13/164 (7%)
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
IRK KI+ ++ F I + T+L+ D K + EY FT I+ E
Sbjct: 118 IRKLAIKILVHSLFNMLI-MCTILTNCVFMTMSNPPDWTKNV----EYT---FTGIYTFE 169
Query: 983 MLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038
L+K +A GF + + W LDF V I F + L + + LR L+ +
Sbjct: 170 SLIKILARGFCLEDFTFLRDPWNWLDFTV-ITFAYVTEFVDLGNVSALRTFRVLRALKTI 228
Query: 1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG 1082
S +K +V ALI++ +V ++ + +F+++G+ LF G
Sbjct: 229 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
Score = 48.5 bits (114), Expect = 5e-05
Identities = 38/164 (23%), Positives = 84/164 (51%), Gaps = 11/164 (6%)
Query: 103 PFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLP---KWRPVLENTLL---GIYT 156
P+ ++ V++ PF L I I ++++ +FM++ + P ++ VL L GI+T
Sbjct: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803
Query: 157 FEILVKLFARGVWAGSFSFLGDPWNWLD-FSVTVFEVIIRYSPLDFIPTLQTARTLRILK 215
E+ +K+ A + + + WN D F V++ + + + ++ + L++ R LR+ K
Sbjct: 804 AEMFLKIIAMD----PYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859
Query: 216 IIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLF 259
+ L L+ ++ + + L + ++ + IF+++GM LF
Sbjct: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 903
Score = 40.4 bits (93), Expect = 0.015
Identities = 44/170 (25%), Positives = 78/170 (45%), Gaps = 29/170 (17%)
Query: 674 FFHSFLNVFRILCGEWVETLWDC-MEVAGQSWCIPFYLMVILIGNLLVLYLFLALVSSFS 732
F +FL++FR++ ++ E L+ + AG+++ I F+++VI +G+ ++ L LA+V+
Sbjct: 370 FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMI-FFVLVIFLGSFYLINLILAVVA--- 425
Query: 733 SCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQN--------VPKDTMD----- 779
+ EE N+A L A K+ +L+ L K Q ++ D
Sbjct: 426 ----MAYEEQNQA---TLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAG 478
Query: 780 ----HVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQS 825
V +S + EL N + K KE+S EKN +S+S
Sbjct: 479 GIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSES 528
Score = 36.6 bits (83), Expect = 0.21
Identities = 36/175 (20%), Positives = 71/175 (40%), Gaps = 26/175 (14%)
Query: 1236 PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSI---FVM 1292
P N ++ ++ FN+++M I + M MS W ++ F
Sbjct: 114 PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFM---------TMSNPPDWTKNVEYTFTG 164
Query: 1293 LYTMECILKLIA--FRCFYFTI---AWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQL 1347
+YT E ++K++A F FT WN DF V+ F+ + V V
Sbjct: 165 IYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV---------TEFVDLGNVSA 215
Query: 1348 ILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF 1402
+ R++ L+ ++ L+ S+ L ++++L + ++A+ G+ F
Sbjct: 216 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 1343 bits (3475), Expect = 0.0
Identities = 695/1292 (53%), Positives = 906/1292 (70%), Gaps = 40/1292 (3%)
Query: 425 GNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHK------------EELEKSKKICP 472
G E T + E++KR S S+D+LED T R + EELE+S++ CP
Sbjct: 667 GQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCP 726
Query: 473 LYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQ 532
WYKFA LIW+C WLK+K V+ ++M PF DL + ICI+LN F+ +EHYPM++Q
Sbjct: 727 PCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQ 786
Query: 533 TNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGM 592
+++L++GNLVF GIFTAEM KIIAM PY YFQ GWNIFD IV L+EL LANV G+
Sbjct: 787 FSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGL 846
Query: 593 ALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
++LR FR+LR+FKL K WPT +L+ + NS AL +L L+L +F A GM+LFGK+
Sbjct: 847 SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS 906
Query: 653 YEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMV 712
Y+E VC I DC+LPRWHMHDFFHSFL VFR+LCGEW+ET+WDCMEVAGQ+ C+ ++MV
Sbjct: 907 YKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMV 966
Query: 713 ILIGNLLVLYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQ 771
++IGNL+VL LFLAL+ SSFSS +++NE NLQ+AV R++KGI++V KI Q
Sbjct: 967 MVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQ 1026
Query: 772 NVPKDTMDHVNEVYVKED--------ISDHTLSELSNTQDFLKDKEKS-----SGTEKNA 818
++E+ ED IS+HT E+ ++LKD + S EK
Sbjct: 1027 KAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYV 1086
Query: 819 T-ENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTV 877
E++ S I +PS++ TVPIA GESD ENL+ +E S+S SKEK+ +SSSE STV
Sbjct: 1087 VDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTV 1146
Query: 878 DI-AISEEEEMFYGGERSKH----LKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVE 932
DI A +E E+ E S C R QIS KGK+W N+RKTC KIVE
Sbjct: 1147 DIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVE 1206
Query: 933 NNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGF 992
+NWF+ FI + LLS+G LAFEDIY++QRKTIK +LEYAD +FTYIFILEMLLKW+AYGF
Sbjct: 1207 HNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF 1266
Query: 993 KAYFSNGWYRLDFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERMKVV 1047
+ YF+N W LDF++V V +SL +K L +++ LRPLR LS+FE M+VV
Sbjct: 1267 QVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVV 1326
Query: 1048 VRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRC 1107
V AL+ +NV LVCL+ WLIFSIMGV+LFAG+FY CI+ T+GE F S V N S C
Sbjct: 1327 VNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSEC 1386
Query: 1108 ESLL-FNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVN 1166
++L+ N++ W+N K+NFDNVG G+LSLLQVATF GW+ IM +A+DS V +QP +E N
Sbjct: 1387 KALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDN 1446
Query: 1167 IYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMY 1226
+YMY YF+ FIIFG F L++ I VIIDNFN+ K K GG +IF+T +Q+K Y +KKL
Sbjct: 1447 LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1506
Query: 1227 EDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWI 1286
+ Q+P+PRP NK QG +FD VT Q F++ +M+LIC + MM++TD QS +M+ LYWI
Sbjct: 1507 KKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWI 1566
Query: 1287 NSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQ 1346
N +F++L+T EC+LKLI+ R +YFTI WNIFDF+VVI SI G+ L + Y V P+L +
Sbjct: 1567 NLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFR 1626
Query: 1347 LILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVK 1406
+I L+RI +LRL KG K L+ LM+SLPAL NI LL+FLVMFIYA+FGM NFAYVK
Sbjct: 1627 VIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK 1686
Query: 1407 KEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDC 1466
+E GI+D+ NFETFGNSM+CLFQ+ AGWDG+L I NS DCDPDK +PG+ V+GDC
Sbjct: 1687 REVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDC 1746
Query: 1467 GNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFD 1526
GNPSVGIF+FVSYI+IS+L++VNMYI V++E ++A+++ + LSEDDF F++VW++FD
Sbjct: 1747 GNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFD 1806
Query: 1527 PDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVM 1586
PD TQ+I+ +KLSDFA ALDPPL +AKPNK QLIA+DLPM GDRIHCLDIL AFTKRV+
Sbjct: 1807 PDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVL 1866
Query: 1587 GQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDK 1646
G+ M+ + ++E F+ +NP K++ EPITTTLKRKQE VSA IIQRAY+ Y L++ K
Sbjct: 1867 GESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVK 1926
Query: 1647 NTSDIHMIDGDRDVHAT--KEGAYFDKAKEKS 1676
S I+ D ++ T KE DK E S
Sbjct: 1927 KVSSIYKKDKGKECDGTPIKEDTLIDKLNENS 1958
Score = 422 bits (1086), Expect = e-117
Identities = 224/469 (47%), Positives = 301/469 (64%), Gaps = 29/469 (6%)
Query: 1 MLASPEPKGLVPFTKESFELIKQHIA-------KTHNEDHEEED-LKPTPDLEVGKKLPF 52
+L P P FT+ES I+Q IA K +D ++E+ KP DLE GK LPF
Sbjct: 5 VLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPF 64
Query: 53 IYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTI 112
IYG++ MVS PLED+DPYY KK TFIVLNK + I RF+A L L+PFN IR+ I
Sbjct: 65 IYGDIPPEMVSVPLEDLDPYYINKK-TFIVLNKGKAISRFSATPALYILTPFNPIRKLAI 123
Query: 113 KVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGS 172
K+LVH F + I+ ++L +CVFM+++N P W +E T GIYTFE L+K+ ARG
Sbjct: 124 KILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 183
Query: 173 FSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIH 232
F+FL DPWNWLDF+V F + + L + L+T R LR LK I + GLK++VG LI
Sbjct: 184 FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243
Query: 233 CLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENE----------------N 276
+K+L V+ILT+F LS+F+LIG+ LFMGNL++KC +WP +N N
Sbjct: 244 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303
Query: 277 ETLHNRTGNPY----YIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQG 332
T NRT + + YI + +FY+LEG+ ALLCGN +DAGQCPEGY+CVKAG NP+ G
Sbjct: 304 GTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYG 363
Query: 333 FTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGI 392
+T+FD+F WA +LFRLM QD+ E LY L A+GK YMIFFV+V FL SFY+ +L L +
Sbjct: 364 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAV 423
Query: 393 LAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKR 441
+AMAYEE+ Q E +++ E +FQQ ++L++ E +A + R
Sbjct: 424 VAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
Score = 144 bits (362), Expect = 9e-34
Identities = 154/688 (22%), Positives = 294/688 (42%), Gaps = 142/688 (20%)
Query: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG----IYTFEILVK 162
+R+T K++ H +F+ FI+ +L+ ++ ++ + T+L ++T+ +++
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
Query: 163 LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216
+ + V G + + W WLDF + ++ + YS L I +L+T R LR L+
Sbjct: 1257 MLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRA 1316
Query: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN 276
+ +G++ +V L+ + ++ V+++ L F IFS++G+ LF G H
Sbjct: 1317 LSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH----------- 1365
Query: 277 ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNF 336
++ TG + + N+ E AL+ N+T + + NF
Sbjct: 1366 -CINYTTGEMFDVSVVNNY----SECKALIESNQTARWKNVK---------------VNF 1405
Query: 337 DSFGWALFALFRLMA-QDYPEVLYH---------QILYASGKVYMIFFVVVSFLFSFYMA 386
D+ G +L ++ + + +++Y Q Y ++FV+ SF+
Sbjct: 1406 DNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTL 1465
Query: 387 SLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPIST 446
+LF+G++ + ++K++ G Q+ T+E K MKK
Sbjct: 1466 NLFIGVIIDNFNQQKKKFGG----------------QDIFMTEEQKKYYNAMKKLGS--- 1506
Query: 447 DTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPF 506
+K +K P KF + V +
Sbjct: 1507 ------------------KKPQKPIPRPANKF----------------QGMVFDFVTKQV 1532
Query: 507 TDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQ 566
D+ ++I I LN+ + +E S++ +L NLVFI +FT E + K+I++ Y YF
Sbjct: 1533 FDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLR-YYYFT 1591
Query: 567 VGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQILMW 618
+GWNIFD ++V ++ + LA + ++RL R+ RI +L K + L++
Sbjct: 1592 IGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1651
Query: 619 SLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSF 678
+L S AL ++ LLLF +F A FGM F Y + ID ++ F +S
Sbjct: 1652 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--YVKREVGID-----DMFNFETFGNSM 1704
Query: 679 LNVFRILCGEWVETLWDCMEVAGQSWCIP---------------------FYLMVILIGN 717
+ +F+I + L + +G C P F++ I+I
Sbjct: 1705 ICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISF 1764
Query: 718 LLVLYLFLALV-SSFSSCKDVTAEENNE 744
L+V+ +++A++ +FS + +AE +E
Sbjct: 1765 LVVVNMYIAVILENFSVATEESAEPLSE 1792
Score = 51.6 bits (122), Expect = 6e-06
Identities = 58/263 (22%), Positives = 120/263 (45%), Gaps = 26/263 (9%)
Query: 401 KQRVGEISKKIEPKFQQTGKELQEG----NETDEAKTIQIEMKKRSPISTDTSLDVLEDA 456
+QR+ E K PK ++ ++ + G ++ + K++ P L+ L+
Sbjct: 26 EQRIAEEKAK-RPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSVPLEDLDPY 84
Query: 457 TLRHKE--ELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIIC 514
+ K L K K I +F+ T ++ +P + +++ +I++ ++ ++
Sbjct: 85 YINKKTFIVLNKGKAIS-----RFSATPALYILTP-FNPIRKLAIKILVHSLFNMLIMCT 138
Query: 515 IILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIA----MHPYGYFQVGWN 570
I+ N F+T+ + P + N+ F GI+T E + KI+A + + + + WN
Sbjct: 139 ILTNCVFMTMSNPP-----DWTKNV-EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWN 192
Query: 571 IFD-SMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKD 629
D ++I F + E ++ ++ LR FR+LR K P + ++ +L S L D
Sbjct: 193 WLDFTVITFAYVTE--FVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSD 250
Query: 630 LVLLLFTFIFFSAAFGMKLFGKN 652
+++L + A G++LF N
Sbjct: 251 VMILTVFCLSVFALIGLQLFMGN 273
Score = 49.3 bits (116), Expect = 3e-05
Identities = 45/164 (27%), Positives = 75/164 (45%), Gaps = 13/164 (7%)
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
IRK KI+ ++ F I + T+L+ D K + EY FT I+ E
Sbjct: 118 IRKLAIKILVHSLFNMLI-MCTILTNCVFMTMSNPPDWTKNV----EYT---FTGIYTFE 169
Query: 983 MLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038
L+K +A GF + + W LDF V I F + L + + LR L+ +
Sbjct: 170 SLIKILARGFCLEDFTFLRDPWNWLDFTV-ITFAYVTEFVDLGNVSALRTFRVLRALKTI 228
Query: 1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG 1082
S +K +V ALI++ +V ++ + +F+++G+ LF G
Sbjct: 229 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
Score = 48.5 bits (114), Expect = 5e-05
Identities = 38/164 (23%), Positives = 84/164 (51%), Gaps = 11/164 (6%)
Query: 103 PFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLP---KWRPVLENTLL---GIYT 156
P+ ++ V++ PF L I I ++++ +FM++ + P ++ VL L GI+T
Sbjct: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803
Query: 157 FEILVKLFARGVWAGSFSFLGDPWNWLD-FSVTVFEVIIRYSPLDFIPTLQTARTLRILK 215
E+ +K+ A + + + WN D F V++ + + + ++ + L++ R LR+ K
Sbjct: 804 AEMFLKIIAMD----PYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859
Query: 216 IIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLF 259
+ L L+ ++ + + L + ++ + IF+++GM LF
Sbjct: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 903
Score = 40.4 bits (93), Expect = 0.015
Identities = 44/170 (25%), Positives = 78/170 (45%), Gaps = 29/170 (17%)
Query: 674 FFHSFLNVFRILCGEWVETLWDC-MEVAGQSWCIPFYLMVILIGNLLVLYLFLALVSSFS 732
F +FL++FR++ ++ E L+ + AG+++ I F+++VI +G+ ++ L LA+V+
Sbjct: 370 FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMI-FFVLVIFLGSFYLINLILAVVA--- 425
Query: 733 SCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQN--------VPKDTMD----- 779
+ EE N+A L A K+ +L+ L K Q ++ D
Sbjct: 426 ----MAYEEQNQA---TLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAG 478
Query: 780 ----HVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQS 825
V +S + EL N + K KE+S EKN +S+S
Sbjct: 479 GIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSES 528
Score = 36.6 bits (83), Expect = 0.21
Identities = 36/175 (20%), Positives = 71/175 (40%), Gaps = 26/175 (14%)
Query: 1236 PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSI---FVM 1292
P N ++ ++ FN+++M I + M MS W ++ F
Sbjct: 114 PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFM---------TMSNPPDWTKNVEYTFTG 164
Query: 1293 LYTMECILKLIA--FRCFYFTI---AWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQL 1347
+YT E ++K++A F FT WN DF V+ F+ + V V
Sbjct: 165 IYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV---------TEFVDLGNVSA 215
Query: 1348 ILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF 1402
+ R++ L+ ++ L+ S+ L ++++L + ++A+ G+ F
Sbjct: 216 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
[Homo sapiens]
Length = 2000
Score = 1308 bits (3385), Expect = 0.0
Identities = 673/1261 (53%), Positives = 892/1261 (70%), Gaps = 40/1261 (3%)
Query: 425 GNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHK------------EELEKSKKICP 472
G E T + E++KR S S+++LED++ R + EELE+S++ CP
Sbjct: 668 GQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCP 727
Query: 473 LYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQ 532
WY+FA FLIW+C WLK+K V+ I+M PF DL + ICI+LN F+ +EHYPM++Q
Sbjct: 728 PCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQ 787
Query: 533 TNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGM 592
+++L +GNLVF GIFTAEM+ KIIAM PY YFQ GWNIFD +IV L+EL L+NV G+
Sbjct: 788 FSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGL 847
Query: 593 ALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
++LR FR+LR+FKL K WPT +L+ + NS AL +L L+L +F A GM+LFGK+
Sbjct: 848 SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS 907
Query: 653 YEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMV 712
Y+E VC I+ DC LPRWHM+DFFHSFL VFR+LCGEW+ET+WDCMEVAGQ+ C+ +++V
Sbjct: 908 YKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLV 967
Query: 713 ILIGNLLVLYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQ 771
++IGNL+VL LFLAL+ SSFSS +++NE NLQ+AV R++KGI+YV K+ Q
Sbjct: 968 MVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQ 1027
Query: 772 NV----PKDTMDHVNEVYVKEDISDHTLSELSNTQDFLKDKEKS-------SGTEKNAT- 819
PK H + +S++T E+S ++L+D + S EK
Sbjct: 1028 KAFFRKPKVIEIHEGNK-IDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVEKYVID 1086
Query: 820 ENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDI 879
EN+ S I +PS++ TVPIA GESD ENL+ +E S+S SKEK+ +SSSE STVD+
Sbjct: 1087 ENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDV 1146
Query: 880 AISEEEEMFYGGERSKHLK------NGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVEN 933
+ E E E + LK GC + Q+S KGKIW N+RKTC IVE+
Sbjct: 1147 VLPREGEQAET-EPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEH 1205
Query: 934 NWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFK 993
NWF+ FI + LLS+G LAFEDIY++QRKTIK +LEYAD +FTYIFILEMLLKW+AYGF+
Sbjct: 1206 NWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQ 1265
Query: 994 AYFSNGWYRLDFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERMKVVV 1048
YF+N W LDF++V V +SL+ +K L +++ LRPLR LS+FE M+VVV
Sbjct: 1266 TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVV 1325
Query: 1049 RALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCE 1108
AL+ +NV LVCL+ WLIFSIMGV+LFAG+FY C++ T+G F S+V N S C+
Sbjct: 1326 NALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQ 1385
Query: 1109 SLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIY 1168
+L + W+N K+NFDNVG G+L+LLQVATF GW+ IM +A+DS V +QP +E N+Y
Sbjct: 1386 AL--GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLY 1443
Query: 1169 MYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYED 1228
MY YF+ FIIFG F L++ I VIIDNFN+ K K GG +IF+T +Q+K Y +KKL +
Sbjct: 1444 MYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1503
Query: 1229 SQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINS 1288
Q+P+PRP NK QG +FD VT Q F++ +M+LIC + MM++TD Q M++ L IN
Sbjct: 1504 PQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINL 1563
Query: 1289 IFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLI 1348
+F++L+T E +LKL++ R +YFTI WNIFDF+VVI SI G+ L + Y V P+L ++I
Sbjct: 1564 VFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1623
Query: 1349 LLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKE 1408
L+RI +LRL KG K L+ LM+SLPAL NI LL+FLVMFIYA+FGM NFAYVKKE
Sbjct: 1624 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKE 1683
Query: 1409 AGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGN 1468
AGI+D+ NFETFGNSM+CLFQ+ AGWDG+L I NS DCDPD I+PG+ V+GDCGN
Sbjct: 1684 AGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGN 1743
Query: 1469 PSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPD 1528
PSVGIF+FVSYI+IS+L++VNMYI V++E ++A+++ + LSEDDF F++VW++FDPD
Sbjct: 1744 PSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPD 1803
Query: 1529 RTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQ 1588
TQ+I+ SKLSDFAAALDPPL +AKPNK QLIA+DLPM GDRIHCLDIL AFTKRV+G+
Sbjct: 1804 ATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGE 1863
Query: 1589 DVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNT 1648
M+ + ++E F+ +NP K++ EPITTTLKRKQE VSA IIQR ++ Y L++ KN
Sbjct: 1864 SGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNI 1923
Query: 1649 S 1649
S
Sbjct: 1924 S 1924
Score = 418 bits (1075), Expect = e-116
Identities = 219/458 (47%), Positives = 296/458 (64%), Gaps = 28/458 (6%)
Query: 1 MLASPEPKGLVPFTKESFELIKQHIA-------KTHNEDHEEEDLKPTPDLEVGKKLPFI 53
+L P P+ FT+ES I++ A K ++ +E KP DLE GK LPFI
Sbjct: 5 LLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFI 64
Query: 54 YGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIK 113
YG++ MVSEPLED+DPYY KK TFIV+NK + IFRF+A S L L+P N +R+ IK
Sbjct: 65 YGDIPPEMVSEPLEDLDPYYINKK-TFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIK 123
Query: 114 VLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSF 173
+LVH F + I+ ++L +CVFM+L+N P W +E T GIYTFE L+K+ ARG F
Sbjct: 124 ILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDF 183
Query: 174 SFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHC 233
+FL DPWNWLDFSV V + + L + L+T R LR LK I + GLK++VG LI
Sbjct: 184 TFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
Query: 234 LKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQE----------------NENE 277
+K+L V+ILT+F LS+F+LIG+ LFMGNL++KC +WP + N
Sbjct: 244 VKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNG 303
Query: 278 TLHNRTGNPY----YIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGF 333
T N T + + YI + +FY L+G++ LLCGN +DAGQCPEGY+CVKAG NP+ G+
Sbjct: 304 TFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGY 363
Query: 334 TNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGIL 393
T+FD+F WA +LFRLM QDY E LY L A+GK YMIFFV+V FL SFY+ +L L ++
Sbjct: 364 TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV 423
Query: 394 AMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEA 431
AMAYEE+ Q E +++ E +FQQ ++L++ E +A
Sbjct: 424 AMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQA 461
Score = 140 bits (353), Expect = 1e-32
Identities = 156/688 (22%), Positives = 292/688 (42%), Gaps = 145/688 (21%)
Query: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG----IYTFEILVK 162
+R+T ++ H +F+ FI+ +L+ ++ ++ + T+L ++T+ +++
Sbjct: 1195 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1254
Query: 163 LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216
+ + V G ++ + W WLDF + ++ + YS L I +L+T R LR L+
Sbjct: 1255 MLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRA 1314
Query: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN 276
+ +G++ +V L+ + ++ V+++ L F IFS++G+ LF G H
Sbjct: 1315 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH----------- 1363
Query: 277 ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNF 336
++ TGN + I + N + N VK NF
Sbjct: 1364 -CVNMTTGNMFDISDVNNLSDCQALGKQARWKN-------------VK---------VNF 1400
Query: 337 DSFGWALFALFRLMA-QDYPEVLYH---------QILYASGKVYMIFFVVVSFLFSFYMA 386
D+ G AL ++ + + +++Y Q +Y ++FV+ SF+
Sbjct: 1401 DNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTL 1460
Query: 387 SLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPIST 446
+LF+G++ + ++K++ G Q+ T+E K MKK
Sbjct: 1461 NLFIGVIIDNFNQQKKKFGG----------------QDIFMTEEQKKYYNAMKKLGS--- 1501
Query: 447 DTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPF 506
+K +K P KF +FV R +
Sbjct: 1502 ------------------KKPQKPIPRPANKFQGMVF------------DFVTRQVF--- 1528
Query: 507 TDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQ 566
D+ ++I I LN+ + +E K +L+ NLVFI +FT E + K++++ Y YF
Sbjct: 1529 -DISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHY-YFT 1586
Query: 567 VGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQILMW 618
+GWNIFD ++V ++ + LA + ++RL R+ RI +L K + L++
Sbjct: 1587 IGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1646
Query: 619 SLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSF 678
+L S AL ++ LLLF +F A FGM F Y + ID ++ F +S
Sbjct: 1647 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--YVKKEAGID-----DMFNFETFGNSM 1699
Query: 679 LNVFRILCGEWVETLW---------DC------------MEVAGQSWCIPFYLMVILIGN 717
+ +F+I + L DC + S I F++ I+I
Sbjct: 1700 ICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISF 1759
Query: 718 LLVLYLFLALV-SSFSSCKDVTAEENNE 744
L+V+ +++A++ +FS + +AE +E
Sbjct: 1760 LVVVNMYIAVILENFSVATEESAEPLSE 1787
Score = 52.4 bits (124), Expect = 4e-06
Identities = 66/269 (24%), Positives = 119/269 (44%), Gaps = 32/269 (11%)
Query: 401 KQRVGEISKKI-EPKFQQTGKELQEGNETDEAKTIQIEMKKRSP-----ISTDTSLDVLE 454
++ + I K+ E K ++ KE +E +E K P I + + LE
Sbjct: 19 RESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDIPPEMVSEPLE 78
Query: 455 DATLRHKEE-----LEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDL 509
D + + + K K I ++F+ T ++ +P K + ++ + F+
Sbjct: 79 DLDPYYINKKTFIVMNKGKAI-----FRFSATSALYILTPLNPVRKIAIKILVHSLFS-- 131
Query: 510 FLIICIILNVC-FLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIA----MHPYGY 564
LI+C IL C F+TL + P + N+ F GI+T E + KI+A + + +
Sbjct: 132 MLIMCTILTNCVFMTLSNPP-----DWTKNV-EYTFTGIYTFESLIKILARGFCLEDFTF 185
Query: 565 FQVGWNIFD-SMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNS 623
+ WN D S+IV + E ++ ++ LR FR+LR K P + ++ +L S
Sbjct: 186 LRDPWNWLDFSVIVMAYVTE--FVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
Query: 624 WVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
L D+++L + A G++LF N
Sbjct: 244 VKKLSDVMILTVFCLSVFALIGLQLFMGN 272
Score = 49.3 bits (116), Expect = 3e-05
Identities = 47/184 (25%), Positives = 86/184 (46%), Gaps = 17/184 (9%)
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
+RK KI+ ++ F I + T+L+ D K + EY FT I+ E
Sbjct: 117 VRKIAIKILVHSLFSMLI-MCTILTNCVFMTLSNPPDWTKNV----EYT---FTGIYTFE 168
Query: 983 MLLKWMAYGFK----AYFSNGWYRLDF-VVVIVFCLSLIGKTREELKPLISMKFLRPLRV 1037
L+K +A GF + + W LDF V+V+ + + + L + + LR L+
Sbjct: 169 SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGN--VSALRTFRVLRALKT 226
Query: 1038 LSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRF-YECID-PTSGER 1095
+S +K +V ALI++ +V ++ + +F+++G+ LF G +C+ P S
Sbjct: 227 ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSA 286
Query: 1096 FPSS 1099
F ++
Sbjct: 287 FETN 290
Score = 47.4 bits (111), Expect = 1e-04
Identities = 34/153 (22%), Positives = 78/153 (50%), Gaps = 11/153 (7%)
Query: 114 VLVHPFFQLFILISVLIDCVFMSLTNLP---KWRPVL---ENTLLGIYTFEILVKLFARG 167
+++ PF L I I ++++ +FM++ + P ++ VL GI+T E+++K+ A
Sbjct: 756 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 815
Query: 168 VWAGSFSFLGDPWNWLDFSVTVFEVI-IRYSPLDFIPTLQTARTLRILKIIPLNQGLKSL 226
+ + + WN D + ++ + S ++ + L++ R LR+ K+ L L
Sbjct: 816 ----PYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNML 871
Query: 227 VGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLF 259
+ ++ + + L + ++ + IF+++GM LF
Sbjct: 872 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 904
Score = 37.4 bits (85), Expect = 0.12
Identities = 24/87 (27%), Positives = 52/87 (59%), Gaps = 4/87 (4%)
Query: 674 FFHSFLNVFRILCGEWVETLWDC-MEVAGQSWCIPFYLMVILIGNLLVLYLFLALVS-SF 731
F +FL++FR++ ++ E L+ + AG+++ I F+++VI +G+ ++ L LA+V+ ++
Sbjct: 369 FSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMI-FFVLVIFLGSFYLVNLILAVVAMAY 427
Query: 732 SSCKDVTAEENNEAK-NLQLAVARIKK 757
T EE + + Q + ++KK
Sbjct: 428 EEQNQATLEEAEQKEAEFQQMLEQLKK 454
>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
[Homo sapiens]
Length = 1951
Score = 1306 bits (3380), Expect = 0.0
Identities = 671/1253 (53%), Positives = 890/1253 (71%), Gaps = 40/1253 (3%)
Query: 433 TIQIEMKKRSPISTDTSLDVLEDATLRHK------------EELEKSKKICPLYWYKFAK 480
T + E++KR S S+++LED++ R + EELE+S++ CP WY+FA
Sbjct: 627 TTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFAN 686
Query: 481 TFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIG 540
FLIW+C WLK+K V+ I+M PF DL + ICI+LN F+ +EHYPM++Q +++L +G
Sbjct: 687 VFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVG 746
Query: 541 NLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRM 600
NLVF GIFTAEM+ KIIAM PY YFQ GWNIFD +IV L+EL L+NV G+++LR FR+
Sbjct: 747 NLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRL 806
Query: 601 LRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHI 660
LR+FKL K WPT +L+ + NS AL +L L+L +F A GM+LFGK+Y+E VC I
Sbjct: 807 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 866
Query: 661 DKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLV 720
+ DC LPRWHM+DFFHSFL VFR+LCGEW+ET+WDCMEVAGQ+ C+ +++V++IGNL+V
Sbjct: 867 NDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVV 926
Query: 721 LYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNV----PK 775
L LFLAL+ SSFSS +++NE NLQ+AV R++KGI+YV K+ Q PK
Sbjct: 927 LNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPK 986
Query: 776 DTMDHVNEVYVKEDISDHTLSELSNTQDFLKDKEKS-------SGTEKNAT-ENESQSLI 827
H + +S++T E+S ++L+D + S EK EN+ S I
Sbjct: 987 VIEIHEGNK-IDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFI 1045
Query: 828 PSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEM 887
+PS++ TVPIA GESD ENL+ +E S+S SKEK+ +SSSE STVD+ + E E
Sbjct: 1046 NNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVVLPREGEQ 1105
Query: 888 FYGGERSKHLK------NGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIG 941
E + LK GC + Q+S KGKIW N+RKTC IVE+NWF+ FI
Sbjct: 1106 AET-EPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIV 1164
Query: 942 LVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWY 1001
+ LLS+G LAFEDIY++QRKTIK +LEYAD +FTYIFILEMLLKW+AYGF+ YF+N W
Sbjct: 1165 FMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWC 1224
Query: 1002 RLDFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTL 1056
LDF++V V +SL+ +K L +++ LRPLR LS+FE M+VVV AL+
Sbjct: 1225 WLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIP 1284
Query: 1057 PTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESM 1116
+NV LVCL+ WLIFSIMGV+LFAG+FY C++ T+G F S+V N S C++L +
Sbjct: 1285 SIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQAL--GKQA 1342
Query: 1117 LWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINF 1176
W+N K+NFDNVG G+L+LLQVATF GW+ IM +A+DS V +QP +E N+YMY YF+ F
Sbjct: 1343 RWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIF 1402
Query: 1177 IIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRP 1236
IIFG F L++ I VIIDNFN+ K K GG +IF+T +Q+K Y +KKL + Q+P+PRP
Sbjct: 1403 IIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP 1462
Query: 1237 LNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTM 1296
NK QG +FD VT Q F++ +M+LIC + MM++TD Q M++ L IN +F++L+T
Sbjct: 1463 ANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTG 1522
Query: 1297 ECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHM 1356
E +LKL++ R +YFTI WNIFDF+VVI SI G+ L + Y V P+L ++I L+RI +
Sbjct: 1523 EFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRI 1582
Query: 1357 LRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSN 1416
LRL KG K L+ LM+SLPAL NI LL+FLVMFIYA+FGM NFAYVKKEAGI+D+ N
Sbjct: 1583 LRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFN 1642
Query: 1417 FETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYF 1476
FETFGNSM+CLFQ+ AGWDG+L I NS DCDPD I+PG+ V+GDCGNPSVGIF+F
Sbjct: 1643 FETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFF 1702
Query: 1477 VSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSS 1536
VSYI+IS+L++VNMYI V++E ++A+++ + LSEDDF F++VW++FDPD TQ+I+ S
Sbjct: 1703 VSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFS 1762
Query: 1537 KLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVV 1596
KLSDFAAALDPPL +AKPNK QLIA+DLPM GDRIHCLDIL AFTKRV+G+ M+ +
Sbjct: 1763 KLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALR 1822
Query: 1597 SEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTS 1649
++E F+ +NP K++ EPITTTLKRKQE VSA IIQR ++ Y L++ KN S
Sbjct: 1823 IQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNIS 1875
Score = 418 bits (1075), Expect = e-116
Identities = 219/458 (47%), Positives = 296/458 (64%), Gaps = 28/458 (6%)
Query: 1 MLASPEPKGLVPFTKESFELIKQHIA-------KTHNEDHEEEDLKPTPDLEVGKKLPFI 53
+L P P+ FT+ES I++ A K ++ +E KP DLE GK LPFI
Sbjct: 5 LLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFI 64
Query: 54 YGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIK 113
YG++ MVSEPLED+DPYY KK TFIV+NK + IFRF+A S L L+P N +R+ IK
Sbjct: 65 YGDIPPEMVSEPLEDLDPYYINKK-TFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIK 123
Query: 114 VLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSF 173
+LVH F + I+ ++L +CVFM+L+N P W +E T GIYTFE L+K+ ARG F
Sbjct: 124 ILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDF 183
Query: 174 SFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHC 233
+FL DPWNWLDFSV V + + L + L+T R LR LK I + GLK++VG LI
Sbjct: 184 TFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
Query: 234 LKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQE----------------NENE 277
+K+L V+ILT+F LS+F+LIG+ LFMGNL++KC +WP + N
Sbjct: 244 VKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNG 303
Query: 278 TLHNRTGNPY----YIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGF 333
T N T + + YI + +FY L+G++ LLCGN +DAGQCPEGY+CVKAG NP+ G+
Sbjct: 304 TFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGY 363
Query: 334 TNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGIL 393
T+FD+F WA +LFRLM QDY E LY L A+GK YMIFFV+V FL SFY+ +L L ++
Sbjct: 364 TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV 423
Query: 394 AMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEA 431
AMAYEE+ Q E +++ E +FQQ ++L++ E +A
Sbjct: 424 AMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQA 461
Score = 140 bits (353), Expect = 1e-32
Identities = 156/688 (22%), Positives = 292/688 (42%), Gaps = 145/688 (21%)
Query: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG----IYTFEILVK 162
+R+T ++ H +F+ FI+ +L+ ++ ++ + T+L ++T+ +++
Sbjct: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205
Query: 163 LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216
+ + V G ++ + W WLDF + ++ + YS L I +L+T R LR L+
Sbjct: 1206 MLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRA 1265
Query: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN 276
+ +G++ +V L+ + ++ V+++ L F IFS++G+ LF G H
Sbjct: 1266 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH----------- 1314
Query: 277 ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNF 336
++ TGN + I + N + N VK NF
Sbjct: 1315 -CVNMTTGNMFDISDVNNLSDCQALGKQARWKN-------------VK---------VNF 1351
Query: 337 DSFGWALFALFRLMA-QDYPEVLYH---------QILYASGKVYMIFFVVVSFLFSFYMA 386
D+ G AL ++ + + +++Y Q +Y ++FV+ SF+
Sbjct: 1352 DNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTL 1411
Query: 387 SLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPIST 446
+LF+G++ + ++K++ G Q+ T+E K MKK
Sbjct: 1412 NLFIGVIIDNFNQQKKKFGG----------------QDIFMTEEQKKYYNAMKKLGS--- 1452
Query: 447 DTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPF 506
+K +K P KF +FV R +
Sbjct: 1453 ------------------KKPQKPIPRPANKFQGMVF------------DFVTRQVF--- 1479
Query: 507 TDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQ 566
D+ ++I I LN+ + +E K +L+ NLVFI +FT E + K++++ Y YF
Sbjct: 1480 -DISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHY-YFT 1537
Query: 567 VGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQILMW 618
+GWNIFD ++V ++ + LA + ++RL R+ RI +L K + L++
Sbjct: 1538 IGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1597
Query: 619 SLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSF 678
+L S AL ++ LLLF +F A FGM F Y + ID ++ F +S
Sbjct: 1598 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--YVKKEAGID-----DMFNFETFGNSM 1650
Query: 679 LNVFRILCGEWVETLW---------DC------------MEVAGQSWCIPFYLMVILIGN 717
+ +F+I + L DC + S I F++ I+I
Sbjct: 1651 ICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISF 1710
Query: 718 LLVLYLFLALV-SSFSSCKDVTAEENNE 744
L+V+ +++A++ +FS + +AE +E
Sbjct: 1711 LVVVNMYIAVILENFSVATEESAEPLSE 1738
Score = 52.4 bits (124), Expect = 4e-06
Identities = 66/269 (24%), Positives = 119/269 (44%), Gaps = 32/269 (11%)
Query: 401 KQRVGEISKKI-EPKFQQTGKELQEGNETDEAKTIQIEMKKRSP-----ISTDTSLDVLE 454
++ + I K+ E K ++ KE +E +E K P I + + LE
Sbjct: 19 RESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDIPPEMVSEPLE 78
Query: 455 DATLRHKEE-----LEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDL 509
D + + + K K I ++F+ T ++ +P K + ++ + F+
Sbjct: 79 DLDPYYINKKTFIVMNKGKAI-----FRFSATSALYILTPLNPVRKIAIKILVHSLFS-- 131
Query: 510 FLIICIILNVC-FLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIA----MHPYGY 564
LI+C IL C F+TL + P + N+ F GI+T E + KI+A + + +
Sbjct: 132 MLIMCTILTNCVFMTLSNPP-----DWTKNV-EYTFTGIYTFESLIKILARGFCLEDFTF 185
Query: 565 FQVGWNIFD-SMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNS 623
+ WN D S+IV + E ++ ++ LR FR+LR K P + ++ +L S
Sbjct: 186 LRDPWNWLDFSVIVMAYVTE--FVSLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
Query: 624 WVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
L D+++L + A G++LF N
Sbjct: 244 VKKLSDVMILTVFCLSVFALIGLQLFMGN 272
Score = 50.1 bits (118), Expect = 2e-05
Identities = 47/184 (25%), Positives = 87/184 (47%), Gaps = 17/184 (9%)
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
+RK KI+ ++ F I + T+L+ D K + EY FT I+ E
Sbjct: 117 VRKIAIKILVHSLFSMLI-MCTILTNCVFMTLSNPPDWTKNV----EYT---FTGIYTFE 168
Query: 983 MLLKWMAYGFK----AYFSNGWYRLDF-VVVIVFCLSLIGKTREELKPLISMKFLRPLRV 1037
L+K +A GF + + W LDF V+V+ + + + + L + + LR L+
Sbjct: 169 SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFV--SLGNVSALRTFRVLRALKT 226
Query: 1038 LSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRF-YECID-PTSGER 1095
+S +K +V ALI++ +V ++ + +F+++G+ LF G +C+ P S
Sbjct: 227 ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSA 286
Query: 1096 FPSS 1099
F ++
Sbjct: 287 FETN 290
Score = 47.4 bits (111), Expect = 1e-04
Identities = 34/153 (22%), Positives = 78/153 (50%), Gaps = 11/153 (7%)
Query: 114 VLVHPFFQLFILISVLIDCVFMSLTNLP---KWRPVL---ENTLLGIYTFEILVKLFARG 167
+++ PF L I I ++++ +FM++ + P ++ VL GI+T E+++K+ A
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 766
Query: 168 VWAGSFSFLGDPWNWLDFSVTVFEVI-IRYSPLDFIPTLQTARTLRILKIIPLNQGLKSL 226
+ + + WN D + ++ + S ++ + L++ R LR+ K+ L L
Sbjct: 767 ----PYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNML 822
Query: 227 VGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLF 259
+ ++ + + L + ++ + IF+++GM LF
Sbjct: 823 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 855
Score = 37.4 bits (85), Expect = 0.12
Identities = 24/87 (27%), Positives = 52/87 (59%), Gaps = 4/87 (4%)
Query: 674 FFHSFLNVFRILCGEWVETLWDC-MEVAGQSWCIPFYLMVILIGNLLVLYLFLALVS-SF 731
F +FL++FR++ ++ E L+ + AG+++ I F+++VI +G+ ++ L LA+V+ ++
Sbjct: 369 FSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMI-FFVLVIFLGSFYLVNLILAVVAMAY 427
Query: 732 SSCKDVTAEENNEAK-NLQLAVARIKK 757
T EE + + Q + ++KK
Sbjct: 428 EEQNQATLEEAEQKEAEFQQMLEQLKK 454
>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
[Homo sapiens]
Length = 1951
Score = 1306 bits (3380), Expect = 0.0
Identities = 671/1253 (53%), Positives = 890/1253 (71%), Gaps = 40/1253 (3%)
Query: 433 TIQIEMKKRSPISTDTSLDVLEDATLRHK------------EELEKSKKICPLYWYKFAK 480
T + E++KR S S+++LED++ R + EELE+S++ CP WY+FA
Sbjct: 627 TTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFAN 686
Query: 481 TFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIG 540
FLIW+C WLK+K V+ I+M PF DL + ICI+LN F+ +EHYPM++Q +++L +G
Sbjct: 687 VFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVG 746
Query: 541 NLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRM 600
NLVF GIFTAEM+ KIIAM PY YFQ GWNIFD +IV L+EL L+NV G+++LR FR+
Sbjct: 747 NLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRL 806
Query: 601 LRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHI 660
LR+FKL K WPT +L+ + NS AL +L L+L +F A GM+LFGK+Y+E VC I
Sbjct: 807 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 866
Query: 661 DKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLV 720
+ DC LPRWHM+DFFHSFL VFR+LCGEW+ET+WDCMEVAGQ+ C+ +++V++IGNL+V
Sbjct: 867 NDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVV 926
Query: 721 LYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNV----PK 775
L LFLAL+ SSFSS +++NE NLQ+AV R++KGI+YV K+ Q PK
Sbjct: 927 LNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPK 986
Query: 776 DTMDHVNEVYVKEDISDHTLSELSNTQDFLKDKEKS-------SGTEKNAT-ENESQSLI 827
H + +S++T E+S ++L+D + S EK EN+ S I
Sbjct: 987 VIEIHEGNK-IDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFI 1045
Query: 828 PSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEM 887
+PS++ TVPIA GESD ENL+ +E S+S SKEK+ +SSSE STVD+ + E E
Sbjct: 1046 NNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVVLPREGEQ 1105
Query: 888 FYGGERSKHLK------NGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIG 941
E + LK GC + Q+S KGKIW N+RKTC IVE+NWF+ FI
Sbjct: 1106 AET-EPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIV 1164
Query: 942 LVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWY 1001
+ LLS+G LAFEDIY++QRKTIK +LEYAD +FTYIFILEMLLKW+AYGF+ YF+N W
Sbjct: 1165 FMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWC 1224
Query: 1002 RLDFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTL 1056
LDF++V V +SL+ +K L +++ LRPLR LS+FE M+VVV AL+
Sbjct: 1225 WLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIP 1284
Query: 1057 PTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESM 1116
+NV LVCL+ WLIFSIMGV+LFAG+FY C++ T+G F S+V N S C++L +
Sbjct: 1285 SIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQAL--GKQA 1342
Query: 1117 LWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINF 1176
W+N K+NFDNVG G+L+LLQVATF GW+ IM +A+DS V +QP +E N+YMY YF+ F
Sbjct: 1343 RWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIF 1402
Query: 1177 IIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRP 1236
IIFG F L++ I VIIDNFN+ K K GG +IF+T +Q+K Y +KKL + Q+P+PRP
Sbjct: 1403 IIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP 1462
Query: 1237 LNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTM 1296
NK QG +FD VT Q F++ +M+LIC + MM++TD Q M++ L IN +F++L+T
Sbjct: 1463 ANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTG 1522
Query: 1297 ECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHM 1356
E +LKL++ R +YFTI WNIFDF+VVI SI G+ L + Y V P+L ++I L+RI +
Sbjct: 1523 EFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRI 1582
Query: 1357 LRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSN 1416
LRL KG K L+ LM+SLPAL NI LL+FLVMFIYA+FGM NFAYVKKEAGI+D+ N
Sbjct: 1583 LRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFN 1642
Query: 1417 FETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYF 1476
FETFGNSM+CLFQ+ AGWDG+L I NS DCDPD I+PG+ V+GDCGNPSVGIF+F
Sbjct: 1643 FETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFF 1702
Query: 1477 VSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSS 1536
VSYI+IS+L++VNMYI V++E ++A+++ + LSEDDF F++VW++FDPD TQ+I+ S
Sbjct: 1703 VSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFS 1762
Query: 1537 KLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVV 1596
KLSDFAAALDPPL +AKPNK QLIA+DLPM GDRIHCLDIL AFTKRV+G+ M+ +
Sbjct: 1763 KLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALR 1822
Query: 1597 SEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTS 1649
++E F+ +NP K++ EPITTTLKRKQE VSA IIQR ++ Y L++ KN S
Sbjct: 1823 IQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNIS 1875
Score = 418 bits (1075), Expect = e-116
Identities = 219/458 (47%), Positives = 296/458 (64%), Gaps = 28/458 (6%)
Query: 1 MLASPEPKGLVPFTKESFELIKQHIA-------KTHNEDHEEEDLKPTPDLEVGKKLPFI 53
+L P P+ FT+ES I++ A K ++ +E KP DLE GK LPFI
Sbjct: 5 LLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFI 64
Query: 54 YGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIK 113
YG++ MVSEPLED+DPYY KK TFIV+NK + IFRF+A S L L+P N +R+ IK
Sbjct: 65 YGDIPPEMVSEPLEDLDPYYINKK-TFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIK 123
Query: 114 VLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSF 173
+LVH F + I+ ++L +CVFM+L+N P W +E T GIYTFE L+K+ ARG F
Sbjct: 124 ILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDF 183
Query: 174 SFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHC 233
+FL DPWNWLDFSV V + + L + L+T R LR LK I + GLK++VG LI
Sbjct: 184 TFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
Query: 234 LKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQE----------------NENE 277
+K+L V+ILT+F LS+F+LIG+ LFMGNL++KC +WP + N
Sbjct: 244 VKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNG 303
Query: 278 TLHNRTGNPY----YIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGF 333
T N T + + YI + +FY L+G++ LLCGN +DAGQCPEGY+CVKAG NP+ G+
Sbjct: 304 TFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGY 363
Query: 334 TNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGIL 393
T+FD+F WA +LFRLM QDY E LY L A+GK YMIFFV+V FL SFY+ +L L ++
Sbjct: 364 TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV 423
Query: 394 AMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEA 431
AMAYEE+ Q E +++ E +FQQ ++L++ E +A
Sbjct: 424 AMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQA 461
Score = 140 bits (353), Expect = 1e-32
Identities = 156/688 (22%), Positives = 292/688 (42%), Gaps = 145/688 (21%)
Query: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG----IYTFEILVK 162
+R+T ++ H +F+ FI+ +L+ ++ ++ + T+L ++T+ +++
Sbjct: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205
Query: 163 LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216
+ + V G ++ + W WLDF + ++ + YS L I +L+T R LR L+
Sbjct: 1206 MLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRA 1265
Query: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN 276
+ +G++ +V L+ + ++ V+++ L F IFS++G+ LF G H
Sbjct: 1266 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH----------- 1314
Query: 277 ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNF 336
++ TGN + I + N + N VK NF
Sbjct: 1315 -CVNMTTGNMFDISDVNNLSDCQALGKQARWKN-------------VK---------VNF 1351
Query: 337 DSFGWALFALFRLMA-QDYPEVLYH---------QILYASGKVYMIFFVVVSFLFSFYMA 386
D+ G AL ++ + + +++Y Q +Y ++FV+ SF+
Sbjct: 1352 DNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTL 1411
Query: 387 SLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPIST 446
+LF+G++ + ++K++ G Q+ T+E K MKK
Sbjct: 1412 NLFIGVIIDNFNQQKKKFGG----------------QDIFMTEEQKKYYNAMKKLGS--- 1452
Query: 447 DTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPF 506
+K +K P KF +FV R +
Sbjct: 1453 ------------------KKPQKPIPRPANKFQGMVF------------DFVTRQVF--- 1479
Query: 507 TDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQ 566
D+ ++I I LN+ + +E K +L+ NLVFI +FT E + K++++ Y YF
Sbjct: 1480 -DISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHY-YFT 1537
Query: 567 VGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQILMW 618
+GWNIFD ++V ++ + LA + ++RL R+ RI +L K + L++
Sbjct: 1538 IGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1597
Query: 619 SLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSF 678
+L S AL ++ LLLF +F A FGM F Y + ID ++ F +S
Sbjct: 1598 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--YVKKEAGID-----DMFNFETFGNSM 1650
Query: 679 LNVFRILCGEWVETLW---------DC------------MEVAGQSWCIPFYLMVILIGN 717
+ +F+I + L DC + S I F++ I+I
Sbjct: 1651 ICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISF 1710
Query: 718 LLVLYLFLALV-SSFSSCKDVTAEENNE 744
L+V+ +++A++ +FS + +AE +E
Sbjct: 1711 LVVVNMYIAVILENFSVATEESAEPLSE 1738
Score = 52.4 bits (124), Expect = 4e-06
Identities = 66/269 (24%), Positives = 119/269 (44%), Gaps = 32/269 (11%)
Query: 401 KQRVGEISKKI-EPKFQQTGKELQEGNETDEAKTIQIEMKKRSP-----ISTDTSLDVLE 454
++ + I K+ E K ++ KE +E +E K P I + + LE
Sbjct: 19 RESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDIPPEMVSEPLE 78
Query: 455 DATLRHKEE-----LEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDL 509
D + + + K K I ++F+ T ++ +P K + ++ + F+
Sbjct: 79 DLDPYYINKKTFIVMNKGKAI-----FRFSATSALYILTPLNPVRKIAIKILVHSLFS-- 131
Query: 510 FLIICIILNVC-FLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIA----MHPYGY 564
LI+C IL C F+TL + P + N+ F GI+T E + KI+A + + +
Sbjct: 132 MLIMCTILTNCVFMTLSNPP-----DWTKNV-EYTFTGIYTFESLIKILARGFCLEDFTF 185
Query: 565 FQVGWNIFD-SMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNS 623
+ WN D S+IV + E ++ ++ LR FR+LR K P + ++ +L S
Sbjct: 186 LRDPWNWLDFSVIVMAYVTE--FVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
Query: 624 WVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
L D+++L + A G++LF N
Sbjct: 244 VKKLSDVMILTVFCLSVFALIGLQLFMGN 272
Score = 49.3 bits (116), Expect = 3e-05
Identities = 47/184 (25%), Positives = 86/184 (46%), Gaps = 17/184 (9%)
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
+RK KI+ ++ F I + T+L+ D K + EY FT I+ E
Sbjct: 117 VRKIAIKILVHSLFSMLI-MCTILTNCVFMTLSNPPDWTKNV----EYT---FTGIYTFE 168
Query: 983 MLLKWMAYGFK----AYFSNGWYRLDF-VVVIVFCLSLIGKTREELKPLISMKFLRPLRV 1037
L+K +A GF + + W LDF V+V+ + + + L + + LR L+
Sbjct: 169 SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGN--VSALRTFRVLRALKT 226
Query: 1038 LSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRF-YECID-PTSGER 1095
+S +K +V ALI++ +V ++ + +F+++G+ LF G +C+ P S
Sbjct: 227 ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSA 286
Query: 1096 FPSS 1099
F ++
Sbjct: 287 FETN 290
Score = 47.4 bits (111), Expect = 1e-04
Identities = 34/153 (22%), Positives = 78/153 (50%), Gaps = 11/153 (7%)
Query: 114 VLVHPFFQLFILISVLIDCVFMSLTNLP---KWRPVL---ENTLLGIYTFEILVKLFARG 167
+++ PF L I I ++++ +FM++ + P ++ VL GI+T E+++K+ A
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 766
Query: 168 VWAGSFSFLGDPWNWLDFSVTVFEVI-IRYSPLDFIPTLQTARTLRILKIIPLNQGLKSL 226
+ + + WN D + ++ + S ++ + L++ R LR+ K+ L L
Sbjct: 767 ----PYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNML 822
Query: 227 VGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLF 259
+ ++ + + L + ++ + IF+++GM LF
Sbjct: 823 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 855
Score = 37.4 bits (85), Expect = 0.12
Identities = 24/87 (27%), Positives = 52/87 (59%), Gaps = 4/87 (4%)
Query: 674 FFHSFLNVFRILCGEWVETLWDC-MEVAGQSWCIPFYLMVILIGNLLVLYLFLALVS-SF 731
F +FL++FR++ ++ E L+ + AG+++ I F+++VI +G+ ++ L LA+V+ ++
Sbjct: 369 FSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMI-FFVLVIFLGSFYLVNLILAVVAMAY 427
Query: 732 SSCKDVTAEENNEAK-NLQLAVARIKK 757
T EE + + Q + ++KK
Sbjct: 428 EEQNQATLEEAEQKEAEFQQMLEQLKK 454
>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
sapiens]
Length = 1998
Score = 1303 bits (3373), Expect = 0.0
Identities = 677/1296 (52%), Positives = 904/1296 (69%), Gaps = 47/1296 (3%)
Query: 425 GNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHK------------EELEKSKKICP 472
G E T + EM+KR S S+D LED + R + EELE+S++ CP
Sbjct: 665 GQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKCP 724
Query: 473 LYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQ 532
WYKF+ FLIW+CSP WLK+K V+ ++M PF DL + ICI+LN F+ +EHYPM+
Sbjct: 725 PCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDH 784
Query: 533 TNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGM 592
N +L +GNLVF GIFTAEM KIIAM PY YFQ GWNIFD IV L+EL LANV G+
Sbjct: 785 FNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGL 844
Query: 593 ALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
++LR FR+LR+FKL K WPT +L+ + NS AL +L L+L +F A GM+LFGK+
Sbjct: 845 SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS 904
Query: 653 YEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMV 712
Y++ VC I DCQLPRWHM+DFFHSFL VFR+LCGEW+ET+WDCMEVAGQ+ C+ ++MV
Sbjct: 905 YKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMV 964
Query: 713 ILIGNLLVLYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKI----- 766
++IGNL+VL LFLAL+ SSFS+ +++NE NLQ+AV R+ KG+ YV KI
Sbjct: 965 MVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQ 1024
Query: 767 --LCKTQNVPKDTMDHVNEVYVKED--ISDHTLSELSNTQDFLKDKEKSS---GTEKNAT 819
+ Q + D + ++++ K+D +S+HT +E+ D+LKD ++ GT +
Sbjct: 1025 QSFIRKQKI-LDEIKPLDDLNNKKDSCMSNHT-AEIGKDLDYLKDVNGTTSGIGTGSSVE 1082
Query: 820 -----ENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSS-E 873
E++ S I +PS++ TVPIA GESD ENL+ ++ S+S SKEK+ +SSSS E
Sbjct: 1083 KYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSE 1142
Query: 874 CSTVDIAISEEEEMFYGGERSKH----LKNGCRRGSSLGQISGASKKGKIWQNIRKTCCK 929
STVDI EE+ E + GC + QI+ +GK W N+R+TC +
Sbjct: 1143 GSTVDIGAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFR 1202
Query: 930 IVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMA 989
IVE+NWF+ FI + LLS+G LAFEDIY+DQRKTIK +LEYAD +FTYIFILEMLLKW+A
Sbjct: 1203 IVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVA 1262
Query: 990 YGFKAYFSNGWYRLDFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERM 1044
YG++ YF+N W LDF++V V +SL +K L +++ LRPLR LS+FE M
Sbjct: 1263 YGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGM 1322
Query: 1045 KVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNK 1104
+VVV AL+ +NV LVCL+ WLIFSIMGV+LFAG+FY CI+ T+G+RF +V N
Sbjct: 1323 RVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNH 1382
Query: 1105 SRCESLLF-NESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHF 1163
+ C L+ NE+ W+N K+NFDNVG G+LSLLQVATF GW+ IM +A+DS V +QP +
Sbjct: 1383 TDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKY 1442
Query: 1164 EVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKK 1223
E ++YMY YF+ FIIFG F L++ I VIIDNFN+ K K GG +IF+T +Q+K Y +KK
Sbjct: 1443 EESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1502
Query: 1224 LMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIAL 1283
L + Q+P+PRP NK QG +FD VT Q F++ +M+LIC + MM++TD QS ++ L
Sbjct: 1503 LGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTIL 1562
Query: 1284 YWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPS 1343
IN +F++L+T EC+LKLI+ R +YFTI WNIFDF+VVI SI G+ L + Y V P+
Sbjct: 1563 SRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPT 1622
Query: 1344 LVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFA 1403
L ++I L+RI +LRL KG K L+ LM+SLPAL NI LL+FLVMFIYA+FGM NFA
Sbjct: 1623 LFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1682
Query: 1404 YVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVR 1463
YVK+E GI+D+ NFETFGNSM+CLFQ+ AGWDG+L I NSK DCDP+K+NPG+ V+
Sbjct: 1683 YVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVK 1742
Query: 1464 GDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWK 1523
GDCGNPSVGIF+FVSYI+IS+L++VNMYI V++E ++A+++ + LSEDDF F++VW+
Sbjct: 1743 GDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWE 1802
Query: 1524 RFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTK 1583
+FDPD TQ+++ KLS FAAAL+PPL + +PNK QLIA+DLPM GDRIHCLDIL AFTK
Sbjct: 1803 KFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTK 1862
Query: 1584 RVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRR 1643
RV+G+ M+ + ++E F+ +NP K++ +PITTTLKRKQE VSA IIQRAY+ + L+R
Sbjct: 1863 RVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKR 1922
Query: 1644 NDKNTS---DIHMIDGDRDVHATKEGAYFDKAKEKS 1676
K S + + I G ++ KE D+ E S
Sbjct: 1923 TVKQASFTYNKNKIKGGANL-LIKEDMIIDRINENS 1957
Score = 424 bits (1090), Expect = e-118
Identities = 232/500 (46%), Positives = 314/500 (62%), Gaps = 32/500 (6%)
Query: 1 MLASPEPKGLVPFTKESFELIKQHIA-------KTHNEDHEEEDLKPTPDLEVGKKLPFI 53
+L P P FT+ES I++ IA K +D +E KP DLE GK LPFI
Sbjct: 5 VLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFI 64
Query: 54 YGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIK 113
YG++ MVSEPLED+DPYY KK TFIVLNK + IFRF+A S L L+PFN +R+ IK
Sbjct: 65 YGDIPPEMVSEPLEDLDPYYINKK-TFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIK 123
Query: 114 VLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSF 173
+LVH F + I+ ++L +CVFM+++N P W +E T GIYTFE L+K+ ARG F
Sbjct: 124 ILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDF 183
Query: 174 SFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHC 233
+FL DPWNWLDF+V F + + L + L+T R LR LK I + GLK++VG LI
Sbjct: 184 TFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
Query: 234 LKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENE---------------NET 278
+K+L V+ILT+F LS+F+LIG+ LFMGNL++KC +WP N N T
Sbjct: 244 VKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGT 303
Query: 279 LHNRTGNPY----YIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFT 334
L N T + YI+++ Y+LEG ALLCGN +DAGQCPEGY+CVKAG NP+ G+T
Sbjct: 304 LINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYT 363
Query: 335 NFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILA 394
+FD+F WA +LFRLM QD+ E LY L A+GK YMIFFV+V FL SFY+ +L L ++A
Sbjct: 364 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 423
Query: 395 MAYEEEKQRVGEISKKIEPKFQQTGKELQEGNE-TDEAKTIQIEMKKRSPIS----TDTS 449
MAYEE+ Q E +++ E +FQQ ++L++ E +A T R P + +D+S
Sbjct: 424 MAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSS 483
Query: 450 LDVLEDATLRHKEELEKSKK 469
+ + ++ KE + KK
Sbjct: 484 SEASKLSSKSAKERRNRRKK 503
Score = 145 bits (367), Expect = 2e-34
Identities = 157/688 (22%), Positives = 298/688 (43%), Gaps = 142/688 (20%)
Query: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG----IYTFEILVK 162
+RRT +++ H +F+ FI+ +L+ ++ ++ + T+L ++T+ +++
Sbjct: 1196 LRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILE 1255
Query: 163 LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216
+ + V G ++ + W WLDF + ++ + YS L I +L+T R LR L+
Sbjct: 1256 MLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRA 1315
Query: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN 276
+ +G++ +V L+ + ++ V+++ L F IFS++G+ LF G H
Sbjct: 1316 LSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH----------- 1364
Query: 277 ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNF 336
++ TG+ + I + N + L+ N T + + NF
Sbjct: 1365 -CINTTTGDRFDIEDVNN----HTDCLKLIERNETARWKNVK---------------VNF 1404
Query: 337 DSFGWALFALFRLMA-QDYPEVLYH---------QILYASGKVYMIFFVVVSFLFSFYMA 386
D+ G+ +L ++ + + +++Y Q Y ++FV+ SF+
Sbjct: 1405 DNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTL 1464
Query: 387 SLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPIST 446
+LF+G++ + ++K++ G Q+ T+E K MKK
Sbjct: 1465 NLFIGVIIDNFNQQKKKFGG----------------QDIFMTEEQKKYYNAMKKLGS--- 1505
Query: 447 DTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPF 506
+K +K P KF +FV R +
Sbjct: 1506 ------------------KKPQKPIPRPGNKFQGMVF------------DFVTRQVF--- 1532
Query: 507 TDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQ 566
D+ ++I I LN+ + +E S+ T+L+ NLVFI +FT E + K+I++ Y YF
Sbjct: 1533 -DISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHY-YFT 1590
Query: 567 VGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQILMW 618
+GWNIFD ++V ++ + LA + ++RL R+ RI +L K + L++
Sbjct: 1591 IGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1650
Query: 619 SLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSF 678
+L S AL ++ LLLF +F A FGM F Y + ID ++ F +S
Sbjct: 1651 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--YVKREVGID-----DMFNFETFGNSM 1703
Query: 679 LNVFRILCGEWVETLW---------DC------------MEVAGQSWCIPFYLMVILIGN 717
+ +F+I + L DC + S I F++ I+I
Sbjct: 1704 ICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISF 1763
Query: 718 LLVLYLFLALV-SSFSSCKDVTAEENNE 744
L+V+ +++A++ +FS + +AE +E
Sbjct: 1764 LVVVNMYIAVILENFSVATEESAEPLSE 1791
Score = 53.5 bits (127), Expect = 2e-06
Identities = 52/198 (26%), Positives = 87/198 (43%), Gaps = 28/198 (14%)
Query: 475 WYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDL--------------FLIICIILNVC 520
+Y KTF++ N + I+ PF L LI+C IL C
Sbjct: 83 YYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNC 142
Query: 521 -FLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIA----MHPYGYFQVGWNIFD-S 574
F+T+ + P + N+ F GI+T E + KIIA + + + + WN D +
Sbjct: 143 VFMTMSNPP-----DWTKNV-EYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFT 196
Query: 575 MIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLL 634
+I F + E ++ ++ LR FR+LR K P + ++ +L S L D+++L
Sbjct: 197 VITFAYVTE--FVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILT 254
Query: 635 FTFIFFSAAFGMKLFGKN 652
+ A G++LF N
Sbjct: 255 VFCLSVFALIGLQLFMGN 272
Score = 51.6 bits (122), Expect = 6e-06
Identities = 41/178 (23%), Positives = 89/178 (50%), Gaps = 12/178 (6%)
Query: 90 FRFNAASILCTLSPFNC-IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPK---WRP 145
++F+ ++ SP+ ++ V++ PF L I I ++++ +FM++ + P +
Sbjct: 728 YKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN 787
Query: 146 VL---ENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLD-FSVTVFEVIIRYSPLDF 201
VL GI+T E+ +K+ A + + + WN D F VT+ V + + ++
Sbjct: 788 VLTVGNLVFTGIFTAEMFLKIIAMD----PYYYFQEGWNIFDGFIVTLSLVELGLANVEG 843
Query: 202 IPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLF 259
+ L++ R LR+ K+ L L+ ++ + + L + ++ + IF+++GM LF
Sbjct: 844 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 901
Score = 48.1 bits (113), Expect = 7e-05
Identities = 44/164 (26%), Positives = 75/164 (45%), Gaps = 13/164 (7%)
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
+RK KI+ ++ F I + T+L+ D K + EY FT I+ E
Sbjct: 117 LRKIAIKILVHSLFSMLI-MCTILTNCVFMTMSNPPDWTKNV----EYT---FTGIYTFE 168
Query: 983 MLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038
L+K +A GF + + W LDF V I F + L + + LR L+ +
Sbjct: 169 SLIKIIARGFCLEDFTFLRDPWNWLDFTV-ITFAYVTEFVDLGNVSALRTFRVLRALKTI 227
Query: 1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG 1082
S +K +V ALI++ +V ++ + +F+++G+ LF G
Sbjct: 228 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
Score = 41.6 bits (96), Expect = 0.007
Identities = 36/153 (23%), Positives = 71/153 (46%), Gaps = 7/153 (4%)
Query: 674 FFHSFLNVFRILCGEWVETLWDC-MEVAGQSWCIPFYLMVILIGNLLVLYLFLALVS-SF 731
F +FL++FR++ ++ E L+ + AG+++ I F+++VI +G+ ++ L LA+V+ ++
Sbjct: 368 FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMI-FFVLVIFLGSFYLINLILAVVAMAY 426
Query: 732 SSCKDVTAEENNEAK-NLQLAVARIKK---GINYVLLKILCKTQNVPKDTMDHVNEVYVK 787
T EE + + Q + ++KK + P +
Sbjct: 427 EEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEA 486
Query: 788 EDISDHTLSELSNTQDFLKDKEKSSGTEKNATE 820
+S + E N + K KE+S G EK+ E
Sbjct: 487 SKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDE 519
Score = 36.2 bits (82), Expect = 0.28
Identities = 37/175 (21%), Positives = 71/175 (40%), Gaps = 26/175 (14%)
Query: 1236 PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSI---FVM 1292
P N L+ ++ F++++M I + M MS W ++ F
Sbjct: 113 PFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMT---------MSNPPDWTKNVEYTFTG 163
Query: 1293 LYTMECILKLIA--FRCFYFTI---AWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQL 1347
+YT E ++K+IA F FT WN DF V+ F+ + V V
Sbjct: 164 IYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYV---------TEFVDLGNVSA 214
Query: 1348 ILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF 1402
+ R++ L+ ++ L+ S+ L ++++L + ++A+ G+ F
Sbjct: 215 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
sapiens]
Length = 1980
Score = 1266 bits (3276), Expect = 0.0
Identities = 647/1247 (51%), Positives = 870/1247 (69%), Gaps = 37/1247 (2%)
Query: 433 TIQIEMKKRSPISTDTSLDVLEDATLRHK-------------EELEKSKKICPLYWYKFA 479
T ++E+KK+ P S S+D L + + EELE+S++ CP WYKFA
Sbjct: 668 TTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFA 727
Query: 480 KTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNI 539
TFLIW C P W+KLKE V+ I+M PF DL + ICI+LN F+ +EH+PM+ Q +L +
Sbjct: 728 NTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAV 787
Query: 540 GNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFR 599
GNLVF GIFTAEM K+IAM PY YFQ GWNIFD IV L+EL LA+V G+++LR FR
Sbjct: 788 GNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFR 847
Query: 600 MLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCH 659
+LR+FKL K WPT +L+ + NS AL +L L+L +F A GM+LFGK+Y+E VC
Sbjct: 848 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCK 907
Query: 660 IDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLL 719
I++DC+LPRWHMHDFFHSFL VFR+LCGEW+ET+WDCMEVAGQ+ C+ ++MV++IGNL+
Sbjct: 908 INQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLV 967
Query: 720 VLYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPK--- 775
VL LFLAL+ SSFS+ +++ E NLQ++V RIKKG+ + LK+ Q K
Sbjct: 968 VLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQRE 1027
Query: 776 -DTMDHVNEVYVKED--ISDHTLSELSNTQDFLKDKEKS-----SGTEKNATENESQSLI 827
D + ++E+Y K+ I++HT +++ DF K+ + S EK + + S I
Sbjct: 1028 ADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFI 1087
Query: 828 PSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEM 887
+P+++ VPIA GESD ENL+ +++ S+S GSK+K+ +SSSE ST+DI EE
Sbjct: 1088 NNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVP 1147
Query: 888 FYGGER----SKHLKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLV 943
E GC + Q++ GK W +RKTC IVE+NWF+ FI +
Sbjct: 1148 VEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFM 1207
Query: 944 TLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRL 1003
LLS+G LAFEDIY++QRKTI+ +LEYAD +FTYIFILEMLLKW AYGF +F+N W L
Sbjct: 1208 ILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWL 1267
Query: 1004 DFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPT 1058
DF++V V +SLI +K L +++ LRPLR LS+FE M+VVV AL+
Sbjct: 1268 DFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSI 1327
Query: 1059 LNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLF--NESM 1116
+NV LVCL+ WLIFSIMGV+LFAG+++ C + TS RF +V NK+ CE L+ N +
Sbjct: 1328 MNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEI 1387
Query: 1117 LWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINF 1176
W+N K+NFDNVG G+L+LLQVATF GW+ IM +A+DS + QP +E NIYMY YF+ F
Sbjct: 1388 RWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIF 1447
Query: 1177 IIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRP 1236
IIFG F L++ I VIIDNFN+ K K GG +IF+T +Q+K Y +KKL + Q+P+PRP
Sbjct: 1448 IIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP 1507
Query: 1237 LNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTM 1296
LNK+QG +FD VT QAF++++M+LIC + MM++TD QS QM LYWIN +FV+ +T
Sbjct: 1508 LNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTC 1567
Query: 1297 ECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHM 1356
EC+LK+ A R +YFTI WNIFDF+VVI SI G+ L + Y V P+L ++I L+RI +
Sbjct: 1568 ECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRI 1627
Query: 1357 LRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSN 1416
LRL KG K L+ LM+SLPAL NI LL+FLVMFI+++FGM NFAYVK EAGI+D+ N
Sbjct: 1628 LRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFN 1687
Query: 1417 FETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYF 1476
FETFGNSM+CLFQ+ AGWDG+L I N + DC DK +PG+ +GDCGNPSVGIF+F
Sbjct: 1688 FETFGNSMICLFQITTSAGWDGLLLPILN-RPPDCSLDKEHPGSGFKGDCGNPSVGIFFF 1746
Query: 1477 VSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSS 1536
VSYI+IS+LI+VNMYI +++E ++A+++ LSEDDF F+++W++FDPD TQ+I+
Sbjct: 1747 VSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYC 1806
Query: 1537 KLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVV 1596
KL+DFA AL+ PL + KPN +LIA+DLPM GDRIHCLDIL AFTKRV+G ++ +
Sbjct: 1807 KLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILR 1866
Query: 1597 SEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRR 1643
++E F+ +NP K++ EPITTTL+RKQE VSA ++QRAY+ + RR
Sbjct: 1867 QQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARR 1913
Score = 419 bits (1078), Expect = e-117
Identities = 219/445 (49%), Positives = 288/445 (64%), Gaps = 15/445 (3%)
Query: 1 MLASPEPKGLVPFTKESFELIKQHIAKT-----------HNEDHEEEDLKPTPDLEVGKK 49
+LA P P PFT ES I++ IA++ H ED E+ KP DLE GK
Sbjct: 5 LLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKS 64
Query: 50 LPFIYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRR 109
LPFIYG++ QG+V+ PLED DPYY +K TF+VLN+ +T+FRF+A L LSPFN IRR
Sbjct: 65 LPFIYGDIPQGLVAVPLEDFDPYYLTQK-TFVVLNRGKTLFRFSATPALYILSPFNLIRR 123
Query: 110 TTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVW 169
IK+L+H F + I+ ++L +CVFM+ +N P W +E T GIYTFE LVK+ ARG
Sbjct: 124 IAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFC 183
Query: 170 AGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGV 229
F+FL DPWNWLDFSV + I + L + L+T R LR LK I + GLK++VG
Sbjct: 184 IDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGA 243
Query: 230 LIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGN---P 286
LI +K+L V+ILT+F LS+F+LIG+ LFMGNL++KC WP L N T
Sbjct: 244 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWE 303
Query: 287 YYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFAL 346
YI NFY + G LLCGN +DAGQCPEGY C+KAG NP+ G+T+FD+F WA AL
Sbjct: 304 EYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLAL 363
Query: 347 FRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGE 406
FRLM QDY E LY L A+GK YMIFFV+V F+ SFY+ +L L ++AMAYEE+ Q E
Sbjct: 364 FRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLE 423
Query: 407 ISKKIEPKFQQTGKELQEGNETDEA 431
+++ E +F+ ++L++ E +A
Sbjct: 424 EAEQKEAEFKAMLEQLKKQQEEAQA 448
Score = 147 bits (371), Expect = 8e-35
Identities = 160/687 (23%), Positives = 294/687 (42%), Gaps = 140/687 (20%)
Query: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG----IYTFEILVK 162
+R+T ++ H +F+ FI+ +L+ ++ ++ + T+L ++T+ +++
Sbjct: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILE 1246
Query: 163 LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216
+ + G F + W WLDF + ++ + YS L I +L+T R LR L+
Sbjct: 1247 MLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRA 1306
Query: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN 276
+ +G++ +V L+ + ++ V+++ L F IFS++G+ LF G H CF N
Sbjct: 1307 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKY-HYCF-------N 1358
Query: 277 ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNF 336
ET R + I + N + E L+ GN T+ I NF
Sbjct: 1359 ETSEIR----FEIEDVNN----KTECEKLMEGNNTE--------------IRWKNVKINF 1396
Query: 337 DSFGWALFALFRLMA-QDYPEVLY---------HQILYASGKVYMIFFVVVSFLFSFYMA 386
D+ G AL ++ + + +++Y Q Y I+FV+ SF+
Sbjct: 1397 DNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTL 1456
Query: 387 SLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPIST 446
+LF+G++ + ++K++ G Q+ T+E K MKK
Sbjct: 1457 NLFIGVIIDNFNQQKKKFGG----------------QDIFMTEEQKKYYNAMKKLGS--- 1497
Query: 447 DTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPF 506
+K +K P P K++ V +
Sbjct: 1498 ------------------KKPQKPIP---------------RPL-NKIQGIVFDFVTQQA 1523
Query: 507 TDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQ 566
D+ +++ I LN+ + +E SKQ +L NLVF+ FT E + K+ A+ Y YF
Sbjct: 1524 FDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHY-YFT 1582
Query: 567 VGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQILMW 618
+GWNIFD ++V ++ + LA++ ++RL R+ RI +L K + L++
Sbjct: 1583 IGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1642
Query: 619 SLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSF 678
+L S AL ++ LLLF +F + FGM F Y + ID ++ F +S
Sbjct: 1643 ALMMSLPALFNIGLLLFLVMFIFSIFGMSNFA--YVKHEAGID-----DMFNFETFGNSM 1695
Query: 679 LNVFRILCGEWVETLW--------DCM------------EVAGQSWCIPFYLMVILIGNL 718
+ +F+I + L DC + S I F++ I+I L
Sbjct: 1696 ICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFL 1755
Query: 719 LVLYLFLALV-SSFSSCKDVTAEENNE 744
+V+ +++A++ +FS + +A+ +E
Sbjct: 1756 IVVNMYIAIILENFSVATEESADPLSE 1782
Score = 64.3 bits (155), Expect = 9e-10
Identities = 95/426 (22%), Positives = 173/426 (40%), Gaps = 87/426 (20%)
Query: 476 YKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVC-FLTLEHYP-MSKQT 533
++F+ T ++ SP L + + +I + F+ +I+C IL C F+T + P SK
Sbjct: 104 FRFSATPALYILSPFNLIRRIAIKILIHSVFS--MIIMCTILTNCVFMTFSNPPDWSKNV 161
Query: 534 NTLLNIGNLVFIGIFTAEMIFKIIA----MHPYGYFQVGWNIFDSMIVFHGLIELCLANV 589
F GI+T E + KIIA + + + + WN D ++ I N+
Sbjct: 162 E-------YTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITE-FVNL 213
Query: 590 AGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLF 649
++ LR FR+LR K P + ++ +L S L D+++L + A G++LF
Sbjct: 214 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 273
Query: 650 -------------------------GKNYEEFV-----------------CHIDKDC-QL 666
G ++EE++ C D Q
Sbjct: 274 MGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQC 333
Query: 667 PRWH---------------MHDFFHSFLNVFRILCGEWVETLWD-CMEVAGQSWCIPFYL 710
P + F +FL +FR++ ++ E L+ + AG+++ I F++
Sbjct: 334 PEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMI-FFV 392
Query: 711 MVILIGNLLVLYLFLALVS-SFSSCKDVTAEENNEAK-NLQLAVARIKKGINYVLLKILC 768
+VI +G+ ++ L LA+V+ ++ T EE + + + + ++KK +
Sbjct: 393 LVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMA 452
Query: 769 KTQ-NVPKDTMDHVNEVYVKEDISDHTLSELS--------NTQDFLKDKEKSSGTEKNAT 819
+ V +D ++ E S +S+LS N + K KE S G EK
Sbjct: 453 TSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDP 512
Query: 820 ENESQS 825
E +S
Sbjct: 513 EKVFKS 518
Score = 51.2 bits (121), Expect = 8e-06
Identities = 41/175 (23%), Positives = 86/175 (49%), Gaps = 13/175 (7%)
Query: 114 VLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLL-------GIYTFEILVKLFAR 166
+++ PF L I I ++++ +FM++ + P P E+ L GI+T E+ +KL A
Sbjct: 749 IVMDPFVDLAITICIVLNTLFMAMEHHPM-TPQFEHVLAVGNLVFTGIFTAEMFLKLIAM 807
Query: 167 GVWAGSFSFLGDPWNWLD-FSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKS 225
+ + + WN D F V++ + + + ++ + L++ R LR+ K+ L
Sbjct: 808 D----PYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNM 863
Query: 226 LVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLH 280
L+ ++ + + L + ++ + IF+++GM LF + K + Q+ E H
Sbjct: 864 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWH 918
Score = 48.9 bits (115), Expect = 4e-05
Identities = 53/208 (25%), Positives = 91/208 (43%), Gaps = 31/208 (14%)
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
IR+ KI+ ++ F I L + + F + D K + EY FT I+ E
Sbjct: 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP-PDWSKNV----EYT---FTGIYTFE 172
Query: 983 MLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038
L+K +A GF + + W LDF V+++ ++ + L + + LR L+ +
Sbjct: 173 SLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGN-VSALRTFRVLRALKTI 231
Query: 1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPS 1098
S +K +V ALI++ +V ++ + +F+++G+ LF G
Sbjct: 232 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG---------------- 275
Query: 1099 SEVMNKSRCESLLFNESMLWENAKMNFD 1126
+ NK + FNES L EN FD
Sbjct: 276 -NLRNKCVVWPINFNESYL-ENGTKGFD 301
Score = 44.3 bits (103), Expect = 0.001
Identities = 46/181 (25%), Positives = 83/181 (45%), Gaps = 25/181 (13%)
Query: 103 PFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGI-------Y 155
P N I+ + F + I++ + ++ V M + + + +EN L I +
Sbjct: 1507 PLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQ-MENILYWINLVFVIFF 1565
Query: 156 TFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFI------PTL---- 205
T E ++K+FA + + WN DF V + ++ + D I PTL
Sbjct: 1566 TCECVLKMFALRHYYFTIG-----WNIFDFVVVILSIVGMFLA-DIIEKYFVSPTLFRVI 1619
Query: 206 QTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKH 265
+ AR RIL++I +G+++L+ L+ L L + +L + IFS+ GM F +KH
Sbjct: 1620 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNF-AYVKH 1678
Query: 266 K 266
+
Sbjct: 1679 E 1679
>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
sapiens]
Length = 1791
Score = 1163 bits (3009), Expect = 0.0
Identities = 696/1780 (39%), Positives = 1003/1780 (56%), Gaps = 182/1780 (10%)
Query: 5 PEPKGLVPFTKESFELIKQHIA----KTHNEDHEEEDLKPTP--DLEVGKKLPFIYGNLS 58
P+ + PFT +S I++ IA K ++D E +P P DL+ +KLP +YG++
Sbjct: 11 PDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVPQPRPQLDLKASRKLPKLYGDIP 70
Query: 59 QGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHP 118
+ ++ +PLED+DP+Y K TF+VLN+ RTI+RF+A L PFN IR I+V VH
Sbjct: 71 RELIGKPLEDLDPFYRNHK-TFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129
Query: 119 FFQLFILISVLIDCVFMSL----TNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFS 174
F +FI+ +V+I+CVFM+ + + E GIY FE L+K+ ARG FS
Sbjct: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189
Query: 175 FLGDPWNWLDFSVTVFEVIIRYSP---LDFIPTLQTARTLRILKIIPLNQGLKSLVGVLI 231
FL DPWNWLD S+ + I+ Y P + +P L+T R R LK I + LK +VG L+
Sbjct: 190 FLRDPWNWLD-SIVIGIAIVSYIPGITIKLLP-LRTFRVFRALKAISVVSRLKVIVGALL 247
Query: 232 HCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRE 291
+K+L+ VIILT F LSIF+L+G LFMG+L KC + + + N + +
Sbjct: 248 RSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCI----SRDCKNISNPEAYDHCFEK 303
Query: 292 TENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMA 351
EN + +CG C Y C INPD +TNFD+FGW+ A+FRLM
Sbjct: 304 KENSPEFK------MCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMT 357
Query: 352 QDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKI 411
QD E LY Q L +G + FF+VV FL SFY+ +L L ++ MAYEE+ + V +
Sbjct: 358 QDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAK 417
Query: 412 EPKFQQ--------------------------------------------------TGKE 421
E FQ+ +GK+
Sbjct: 418 EKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKD 477
Query: 422 LQEGNETDE---AKTIQIEMKKR--------------SPISTDTSLDVLEDATLRHKEEL 464
G+++DE K +E KR P+ +L + T+ KE+
Sbjct: 478 QPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITMKEQ- 536
Query: 465 EKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTL 524
EKS++ C A +L+WNC P WL +K+ + ++ PFT+L + ICII+N FL +
Sbjct: 537 EKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAM 596
Query: 525 EHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIEL 584
EH+ M +LNIGNLVF IF AEM KIIA+ PY YF+ GWNIFDS++ ++
Sbjct: 597 EHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADV 656
Query: 585 --CLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSA 642
C+ LR FR+LR+FKL K WPT L+ + NS AL L ++L IF +
Sbjct: 657 MNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFS 716
Query: 643 AFGMKLFGKNYEEFVCHIDKDCQ--------LPRWHMHDFFHSFLNVFRILCGEWVETLW 694
GM+LFG+++ K C L WHM DF+HSFL VFRILCGEW+E +W
Sbjct: 717 VVGMQLFGRSFNSQKS--PKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMW 774
Query: 695 DCMEVAG--QSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTAEENNEAKN--LQL 750
+CM+ A S C+ ++++ +IG L+VL LF+AL+ + S ++ EA+ +QL
Sbjct: 775 ECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQL 834
Query: 751 AVARIKKGINYVLLKI------LCKTQNVP-------------KDTMDHVNEVY----VK 787
A+ R ++ +V + C+ QN+P KD + V E+ +
Sbjct: 835 ALDRFRRAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSETQ 894
Query: 788 EDISDHT--------------LSELSNTQDFLKDKEKSSGT-------EKNATENESQSL 826
E++ T L+ L+ +D ++ + + E+ A E ++
Sbjct: 895 EELGILTSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQENK 954
Query: 827 IPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDI--AISEE 884
P+ ++V I D +L ++ + KS S SECST+D+
Sbjct: 955 KPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSD--------VTSILSECSTIDLQDGFGWL 1006
Query: 885 EEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVT 944
EM + + L G + IW N+RKTC +IV+++WF+ FI V
Sbjct: 1007 PEMVPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVI 1066
Query: 945 LLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLD 1004
LLS+G L FED++++ + I+ LL D+IFT+IFILEM+LKW+A+GF YF++ W LD
Sbjct: 1067 LLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLD 1126
Query: 1005 FVVVIVFCLSLIGKTREELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLV 1064
F++VIV +LI ELK +++ LRPLR LSQFE MKVVV ALI LNV LV
Sbjct: 1127 FIIVIVSVTTLINLM--ELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLV 1184
Query: 1065 CLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMN 1124
CL+ WL+F I+GV F+G+F +CI+ T + + NKS+CES F+ W N K+N
Sbjct: 1185 CLIFWLVFCILGVYFFSGKFGKCINGTDSV-INYTIITNKSQCESGNFS----WINQKVN 1239
Query: 1125 FDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLP 1184
FDNVGN +L+LLQVATF GW+ I+ +A+DS QP FE N Y YF+ FIIFG F
Sbjct: 1240 FDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFT 1299
Query: 1185 LSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFI 1244
L++ I VIIDNFN+ + KLGG +IF+T +Q+K Y +KKL + Q+P+PRPLNK QG +
Sbjct: 1300 LNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLV 1359
Query: 1245 FDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIA 1304
FD+VTSQ F++I++ LI I+MM ++ Q M L +N +FV+++T+EC++K+ A
Sbjct: 1360 FDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFA 1419
Query: 1305 FRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLV--PPSLVQLILLSRIIHMLRLGKG 1362
R +YFT WN+FD +VV+ SI + + PP+L +++ L+RI +LRL +
Sbjct: 1420 LRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479
Query: 1363 PKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGN 1422
+ L+ LM+SLP+L NI LL+FL+MFIYA+ GM F+ V E+GI+D+ NF+TF +
Sbjct: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFAS 1539
Query: 1423 SMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILI 1482
SMLCLFQ++ AGWD +L + SK S C+ N C P + YFVSYI+I
Sbjct: 1540 SMLCLFQISTSAGWDSLLSPMLRSKES-CNSSSEN--------CHLPGIATSYFVSYIII 1590
Query: 1483 SWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFA 1542
S+LI+VNMYI V++E N A+++ L EDDF F++VW++FDP+ TQ+I S LSDFA
Sbjct: 1591 SFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFA 1650
Query: 1543 AALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESG 1602
AL PL +AKPNK Q + +DLPM DR+HC+DIL AFT RV+G ++ + + +E
Sbjct: 1651 DALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEK 1710
Query: 1603 FLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLR 1642
F+ ANP K EPI TT KRK+E A IIQ+A++ Y ++
Sbjct: 1711 FMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK 1750
>gi|237512982 voltage-gated sodium channel type V alpha isoform f
[Homo sapiens]
Length = 1962
Score = 1139 bits (2946), Expect = 0.0
Identities = 601/1213 (49%), Positives = 811/1213 (66%), Gaps = 40/1213 (3%)
Query: 462 EELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCF 521
EELE+S+ CP W + A+ +LIW C P W+ +K+ V ++M PFTDL + +CI+LN F
Sbjct: 674 EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLF 733
Query: 522 LTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGL 581
+ LEHY M+ + +L +GNLVF GIFTAEM FKIIA+ PY YFQ GWNIFDS+IV L
Sbjct: 734 MALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSL 793
Query: 582 IELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFS 641
+EL L+ ++ +++LR FR+LR+FKL K WPT L+ + NS AL +L L+L +F
Sbjct: 794 MELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIF 853
Query: 642 AAFGMKLFGKNYEEFVCHIDKDCQL-PRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVA 700
A GM+LFGKNY E D D L PRWHM DFFH+FL +FRILCGEW+ET+WDCMEV+
Sbjct: 854 AVVGMQLFGKNYSELR---DSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVS 910
Query: 701 GQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTA-EENNEAKNLQLAVARIKKGI 759
GQS C+ +L+V++IGNL+VL LFLAL+ S S ++TA +E+ E NLQLA+ARI++G+
Sbjct: 911 GQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGL 970
Query: 760 NYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDFLK--------DKEKS 811
+V + T D + + L+ + + EK
Sbjct: 971 RFV-----------KRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKV 1019
Query: 812 SGTEKNATENESQSL---IPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQ 868
T K E + P VPIA ESD ++ + E S + S ++ +
Sbjct: 1020 PPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQTPE 1079
Query: 869 SSSSECSTVDIAISEE--EEMFYGGERSKHLKN----GCRRGSSLGQISGASKKGKIWQN 922
S SE ST D+ + E E++ G+ K ++ GC R + GK+W
Sbjct: 1080 DSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWR 1139
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
+RKTC IVE++WF+ FI + LLS+G LAFEDIY+++RKTIK+LLEYAD +FTY+F+LE
Sbjct: 1140 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1199
Query: 983 MLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKT-----REELKPLISMKFLRPLRV 1037
MLLKW+AYGFK YF+N W LDF++V V +SL+ T +K L +++ LRPLR
Sbjct: 1200 MLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRA 1259
Query: 1038 LSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGER-F 1096
LS+FE M+VVV AL+ +NV LVCL+ WLIFSIMGV+LFAG+F CI+ T G+
Sbjct: 1260 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPL 1319
Query: 1097 PSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVA 1156
+ V NKS+CESL + W K+NFDNVG G+L+LLQVATF GW+ IM +A+DS
Sbjct: 1320 NYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRG 1379
Query: 1157 VNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRK 1216
QP +E N+YMY YF+ FIIFG F L++ I VIIDNFN+ K KLGG +IF+T +Q+K
Sbjct: 1380 YEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKK 1439
Query: 1217 QYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQS 1276
Y +KKL + Q+P+PRPLNK QGFIFD+VT QAF+V +M LIC + MM++TD QS
Sbjct: 1440 YYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQS 1499
Query: 1277 LQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVG 1336
+ L IN +FV ++T ECI+KL A R +YFT +WNIFDF+VVI SI G L +
Sbjct: 1500 PEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQ 1559
Query: 1337 SYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAV 1396
Y P+L ++I L+RI +LRL +G K L+ LM+SLPAL NI LL+FLVMFIY++
Sbjct: 1560 KYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSI 1619
Query: 1397 FGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKI 1456
FGM NFAYVK EAGI+D+ NF+TF NSMLCLFQ+ AGWDG+L I N+ CDP
Sbjct: 1620 FGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLP 1679
Query: 1457 NPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFR 1516
N RGDCG+P+VGI +F +YI+IS+LI+VNMYI +++E ++A+++ + LSEDDF
Sbjct: 1680 NSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFD 1738
Query: 1517 KFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLD 1576
F+++W++FDP+ TQ+I+ S LSDFA AL PL +AKPN+ LI +DLPM GDRIHC+D
Sbjct: 1739 MFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMD 1798
Query: 1577 ILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAY 1636
IL AFTKRV+G+ M+ + ++E F+ ANP KI+ EPITTTL+RK E VSA +IQRA+
Sbjct: 1799 ILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAF 1858
Query: 1637 KNYRLRRNDKNTS 1649
+ + L+R+ K+ S
Sbjct: 1859 RRHLLQRSLKHAS 1871
Score = 381 bits (979), Expect = e-105
Identities = 209/463 (45%), Positives = 286/463 (61%), Gaps = 36/463 (7%)
Query: 13 FTKESFELIKQHIAK-------THNEDHE----EEDLKPTPDLEVGKKLPFIYGNLSQGM 61
FT+ES I++ +A+ T E E EE +P DL+ KKLP +YGN Q +
Sbjct: 16 FTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQEL 75
Query: 62 VSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQ 121
+ EPLED+DP+Y +K TFIVLNK +TIFRF+A + L LSPF+ IRR +K+LVH F
Sbjct: 76 IGEPLEDLDPFYSTQK-TFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFN 134
Query: 122 LFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWN 181
+ I+ ++L +CVFM+ + P W +E T IYTFE LVK+ ARG +F+FL DPWN
Sbjct: 135 MLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWN 194
Query: 182 WLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVI 241
WLDFSV + + L + L+T R LR LK I + GLK++VG LI +K+L V+
Sbjct: 195 WLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVM 254
Query: 242 ILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGN------------PYYI 289
+LT+F LS+F+LIG+ LFMGNL+HKC R N T N T Y+
Sbjct: 255 VLTVFCLSVFALIGLQLFMGNLRHKCVR------NFTALNGTNGSVEADGLVWESLDLYL 308
Query: 290 RETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRL 349
+ EN+ G LLCGN +DAG CPEGY C+KAG NPD G+T+FDSF WA ALFRL
Sbjct: 309 SDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRL 368
Query: 350 MAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISK 409
M QD E LY Q L ++GK+YMIFF++V FL SFY+ +L L ++AMAYEE+ Q ++
Sbjct: 369 MTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
Query: 410 KIEPKFQQTGKELQEGNE------TDEAKTIQIEMKKRSPIST 446
+ E +FQ+ + L++ +E D +EM +P+++
Sbjct: 429 EKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNS 471
Score = 132 bits (332), Expect = 3e-30
Identities = 154/689 (22%), Positives = 291/689 (42%), Gaps = 149/689 (21%)
Query: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNL----PKWRPVLENTLLGIYTFEILVK 162
+R+T ++ H +F+ FI+ +L+ ++ ++ K VL ++T+ +++
Sbjct: 1140 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1199
Query: 163 LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216
+ + V G + + W WLDF + ++ + ++ + I +L+T R LR L+
Sbjct: 1200 MLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRA 1259
Query: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQ---- 272
+ +G++ +V L+ + ++ V+++ L F IFS++G+ LF G +C +
Sbjct: 1260 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCINQTEGDLP 1318
Query: 273 --------ENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVK 324
+++ E+L N TG Y+ + NF + G Y L T G Y V
Sbjct: 1319 LNYTIVNNKSQCESL-NLTGELYWTKVKVNFDNV-GAGYLALLQVATFKGWMDIMYAAV- 1375
Query: 325 AGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFY 384
DS G+ ++ P+ Y+ +Y I+FV+ SF+
Sbjct: 1376 ------------DSRGY----------EEQPQWEYNLYMY-------IYFVIFIIFGSFF 1406
Query: 385 MASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPI 444
+LF+G++ + ++K+++G Q+ T+E K MKK
Sbjct: 1407 TLNLFIGVIIDNFNQQKKKLGG----------------QDIFMTEEQKKYYNAMKKLGS- 1449
Query: 445 STDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMA 504
+K +K P K+ + F+ I+
Sbjct: 1450 --------------------KKPQKPIPRPLNKY----------------QGFIFDIVTK 1473
Query: 505 PFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGY 564
D+ ++ I LN+ + +E S + +L NL+F+ IFT E I K+ A+ Y Y
Sbjct: 1474 QAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHY-Y 1532
Query: 565 FQVGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQIL 616
F WNIFD ++V ++ L+++ ++RL R+ RI +L + + L
Sbjct: 1533 FTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTL 1592
Query: 617 MWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFH 676
+++L S AL ++ LLLF +F + FGM F Y ++ ID ++ F +
Sbjct: 1593 LFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA--YVKWEAGID-----DMFNFQTFAN 1645
Query: 677 SFLNVFRILCGEWVETLWDCMEVAGQSWCIP--------------------FYLMVILIG 716
S L +F+I + L + G +C P F+ I+I
Sbjct: 1646 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIIS 1705
Query: 717 NLLVLYLFLALV-SSFSSCKDVTAEENNE 744
L+V+ +++A++ +FS V EE+ E
Sbjct: 1706 FLIVVNMYIAIILENFS----VATEESTE 1730
Score = 67.8 bits (164), Expect = 9e-11
Identities = 59/240 (24%), Positives = 107/240 (44%), Gaps = 11/240 (4%)
Query: 854 QSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGA 913
Q+ DG + +Q + S S + A+ E EE S+H C + L Q
Sbjct: 646 QAPCVDGFEEPGARQRALSAVSVLTSALEELEE-------SRHKCPPC--WNRLAQRYLI 696
Query: 914 SKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADM 973
+ +W +I++ +V + + I + +L+T +A E M + +L+ ++
Sbjct: 697 WECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNL 754
Query: 974 IFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLR 1033
+FT IF EM K +A YF GW D ++VI+ + L L L S + LR
Sbjct: 755 VFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLR 814
Query: 1034 PLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSG 1093
++ + + +++ + + N+ LV +I IF+++G+ LF + E D SG
Sbjct: 815 VFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSG 874
Score = 54.7 bits (130), Expect = 7e-07
Identities = 73/350 (20%), Positives = 147/350 (42%), Gaps = 65/350 (18%)
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
IR+ KI+ ++ F I + T+L+ ++M Q +Y + FT I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLI-MCTILTNC------VFMAQHDPPP-WTKYVEYTFTAIYTFE 171
Query: 983 MLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038
L+K +A GF + + W LDF V+I+ +S K L L + + LR L+ +
Sbjct: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGN-LSALRTFRVLRALKTI 230
Query: 1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG-------RFYECIDPT 1091
S +K +V ALI++ +V ++ + +F+++G+ LF G R + ++ T
Sbjct: 231 SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGT 290
Query: 1092 SGE---------------RFPSSEVMNKSRCESLLFNES-------------MLWEN--- 1120
+G P + ++ + LL S EN
Sbjct: 291 NGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDH 350
Query: 1121 AKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFG 1180
+FD+ FL+L ++ T + W + + S IYM +F+ I G
Sbjct: 351 GYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFMLVIFLG 400
Query: 1181 VFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQ 1230
F +++++ V+ + + + I T ++ K+++ +++ ++ +
Sbjct: 401 SFYLVNLILAVVAMAYEEQ----NQATIAETEEKEKRFQEAMEMLKKEHE 446
Score = 53.5 bits (127), Expect = 2e-06
Identities = 52/234 (22%), Positives = 92/234 (39%), Gaps = 41/234 (17%)
Query: 454 EDATLRHKEELEKSKKICPLY-----------------WYKFAKTFLIWNCSPCWLKLKE 496
E+ R + +L+ SKK+ LY +Y KTF++ N +
Sbjct: 48 EEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSA 107
Query: 497 FVHRIIMAPFTDL--------------FLIICIILNVCFLTLEHYPMSKQTNTLLNIGNL 542
+++PF + LI+C IL C +H P
Sbjct: 108 TNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP-----PPWTKYVEY 162
Query: 543 VFIGIFTAEMIFKIIA----MHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLF 598
F I+T E + KI+A +H + + + WN D ++ + + + ++ LR F
Sbjct: 163 TFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENI-KLGNLSALRTF 221
Query: 599 RMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
R+LR K P + ++ +L S L D+++L + A G++LF N
Sbjct: 222 RVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGN 275
Score = 45.4 bits (106), Expect = 5e-04
Identities = 34/156 (21%), Positives = 74/156 (47%), Gaps = 11/156 (7%)
Query: 114 VLVHPFFQLFILISVLIDCVFMSL------TNLPKWRPVLENTLLGIYTFEILVKLFARG 167
V++ PF L I + ++++ +FM+L + + V GI+T E+ K+ A
Sbjct: 713 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA-- 770
Query: 168 VWAGSFSFLGDPWNWLDFSVTVFEVI-IRYSPLDFIPTLQTARTLRILKIIPLNQGLKSL 226
+ + WN D + + ++ + S + + L++ R LR+ K+ L +L
Sbjct: 771 --LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTL 828
Query: 227 VGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGN 262
+ ++ + + L + ++ + IF+++GM LF N
Sbjct: 829 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864
>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
sapiens]
Length = 2015
Score = 1125 bits (2911), Expect = 0.0
Identities = 605/1258 (48%), Positives = 825/1258 (65%), Gaps = 77/1258 (6%)
Query: 462 EELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCF 521
EELE+S+ CP W + A+ +LIW C P W+ +K+ V ++M PFTDL + +CI+LN F
Sbjct: 674 EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLF 733
Query: 522 LTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGL 581
+ LEHY M+ + +L +GNLVF GIFTAEM FKIIA+ PY YFQ GWNIFDS+IV L
Sbjct: 734 MALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSL 793
Query: 582 IELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFS 641
+EL L+ ++ +++LR FR+LR+FKL K WPT L+ + NS AL +L L+L +F
Sbjct: 794 MELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIF 853
Query: 642 AAFGMKLFGKNYEEFVCHIDKDC-QLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVA 700
A GM+LFGKNY E D D LPRWHM DFFH+FL +FRILCGEW+ET+WDCMEV+
Sbjct: 854 AVVGMQLFGKNYSEL---RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVS 910
Query: 701 GQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTA-EENNEAKNLQLAVARIKKGI 759
GQS C+ +L+V++IGNL+VL LFLAL+ S S ++TA +E+ E NLQLA+ARI++G+
Sbjct: 911 GQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGL 970
Query: 760 NYV---LLKILC--------------------------------KTQNVP---KDTMDHV 781
+V C +T+ VP K+T
Sbjct: 971 RFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEE 1030
Query: 782 NEVYVKEDISDH-----TLSELSNTQDFLKDKEKSS-GTEKNATENESQSLIPSPSVSET 835
E + D ++ + D ++ E++S GTE+ +++ ESQ + P E
Sbjct: 1031 GEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQESQPVSGGP---EA 1087
Query: 836 VPIASGESDIENLDNKEIQSKSGDGGSKEKIK------------QSSSSECSTVDIAISE 883
P + S + + E ++ + +++ K + S SE ST D+ +
Sbjct: 1088 PPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTA 1147
Query: 884 E--EEMFYGGERSKH----LKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFK 937
E E++ G+ K GC R + GK+W +RKTC IVE++WF+
Sbjct: 1148 ELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFE 1207
Query: 938 CFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFS 997
FI + LLS+G LAFEDIY+++RKTIK+LLEYAD +FTY+F+LEMLLKW+AYGFK YF+
Sbjct: 1208 TFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFT 1267
Query: 998 NGWYRLDFVVVIVFCLSLIGKT-----REELKPLISMKFLRPLRVLSQFERMKVVVRALI 1052
N W LDF++V V +SL+ T +K L +++ LRPLR LS+FE M+VVV AL+
Sbjct: 1268 NAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALV 1327
Query: 1053 KTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGE-RFPSSEVMNKSRCESLL 1111
+NV LVCL+ WLIFSIMGV+LFAG+F CI+ T G+ + V NKS+CESL
Sbjct: 1328 GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLN 1387
Query: 1112 FNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYC 1171
+ W K+NFDNVG G+L+LLQVATF GW+ IM +A+DS QP +E N+YMY
Sbjct: 1388 LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYI 1447
Query: 1172 YFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQR 1231
YF+ FIIFG F L++ I VIIDNFN+ K KLGG +IF+T +Q+K Y +KKL + Q+
Sbjct: 1448 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1507
Query: 1232 PVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFV 1291
P+PRPLNK QGFIFD+VT QAF+V +M LIC + MM++TD QS + L IN +FV
Sbjct: 1508 PIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFV 1567
Query: 1292 MLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLS 1351
++T ECI+KL A R +YFT +WNIFDF+VVI SI G L + Y P+L ++I L+
Sbjct: 1568 AIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLA 1627
Query: 1352 RIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGI 1411
RI +LRL +G K L+ LM+SLPAL NI LL+FLVMFIY++FGM NFAYVK EAGI
Sbjct: 1628 RIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGI 1687
Query: 1412 NDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSV 1471
+D+ NF+TF NSMLCLFQ+ AGWDG+L I N+ CDP N RGDCG+P+V
Sbjct: 1688 DDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAV 1746
Query: 1472 GIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQ 1531
GI +F +YI+IS+LI+VNMYI +++E ++A+++ + LSEDDF F+++W++FDP+ TQ
Sbjct: 1747 GILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQ 1806
Query: 1532 YIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVR 1591
+I+ S LSDFA AL PL +AKPN+ LI +DLPM GDRIHC+DIL AFTKRV+G+
Sbjct: 1807 FIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGE 1866
Query: 1592 MEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTS 1649
M+ + ++E F+ ANP KI+ EPITTTL+RK E VSA +IQRA++ + L+R+ K+ S
Sbjct: 1867 MDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHAS 1924
Score = 383 bits (983), Expect = e-106
Identities = 209/463 (45%), Positives = 286/463 (61%), Gaps = 36/463 (7%)
Query: 13 FTKESFELIKQHIAK-------THNEDHE----EEDLKPTPDLEVGKKLPFIYGNLSQGM 61
FT+ES I++ +A+ T E E EE +P DL+ KKLP +YGN Q +
Sbjct: 16 FTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQEL 75
Query: 62 VSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQ 121
+ EPLED+DP+Y +K TFIVLNK +TIFRF+A + L LSPF+ IRR +K+LVH F
Sbjct: 76 IGEPLEDLDPFYSTQK-TFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFN 134
Query: 122 LFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWN 181
+ I+ ++L +CVFM+ + P W +E T IYTFE LVK+ ARG +F+FL DPWN
Sbjct: 135 MLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWN 194
Query: 182 WLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVI 241
WLDFSV + + L + L+T R LR LK I + GLK++VG LI +K+L V+
Sbjct: 195 WLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVM 254
Query: 242 ILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGN------------PYYI 289
+LT+F LS+F+LIG+ LFMGNL+HKC R N T N T Y+
Sbjct: 255 VLTVFCLSVFALIGLQLFMGNLRHKCVR------NFTALNGTNGSVEADGLVWESLDLYL 308
Query: 290 RETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRL 349
+ EN+ G LLCGN +DAG CPEGY C+KAG NPD G+T+FDSF WA ALFRL
Sbjct: 309 SDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRL 368
Query: 350 MAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISK 409
M QD E LY Q L ++GK+YMIFF++V FL SFY+ +L L ++AMAYEE+ Q ++
Sbjct: 369 MTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
Query: 410 KIEPKFQQTGKELQEGNE------TDEAKTIQIEMKKRSPIST 446
+ E +FQ+ + L++ +E D +EM +P+++
Sbjct: 429 EKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNS 471
Score = 132 bits (332), Expect = 3e-30
Identities = 154/689 (22%), Positives = 291/689 (42%), Gaps = 149/689 (21%)
Query: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNL----PKWRPVLENTLLGIYTFEILVK 162
+R+T ++ H +F+ FI+ +L+ ++ ++ K VL ++T+ +++
Sbjct: 1193 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1252
Query: 163 LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216
+ + V G + + W WLDF + ++ + ++ + I +L+T R LR L+
Sbjct: 1253 MLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRA 1312
Query: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQ---- 272
+ +G++ +V L+ + ++ V+++ L F IFS++G+ LF G +C +
Sbjct: 1313 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCINQTEGDLP 1371
Query: 273 --------ENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVK 324
+++ E+L N TG Y+ + NF + G Y L T G Y V
Sbjct: 1372 LNYTIVNNKSQCESL-NLTGELYWTKVKVNFDNV-GAGYLALLQVATFKGWMDIMYAAV- 1428
Query: 325 AGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFY 384
DS G+ ++ P+ Y+ +Y I+FV+ SF+
Sbjct: 1429 ------------DSRGY----------EEQPQWEYNLYMY-------IYFVIFIIFGSFF 1459
Query: 385 MASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPI 444
+LF+G++ + ++K+++G Q+ T+E K MKK
Sbjct: 1460 TLNLFIGVIIDNFNQQKKKLGG----------------QDIFMTEEQKKYYNAMKKLGS- 1502
Query: 445 STDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMA 504
+K +K P K+ + F+ I+
Sbjct: 1503 --------------------KKPQKPIPRPLNKY----------------QGFIFDIVTK 1526
Query: 505 PFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGY 564
D+ ++ I LN+ + +E S + +L NL+F+ IFT E I K+ A+ Y Y
Sbjct: 1527 QAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHY-Y 1585
Query: 565 FQVGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQIL 616
F WNIFD ++V ++ L+++ ++RL R+ RI +L + + L
Sbjct: 1586 FTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTL 1645
Query: 617 MWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFH 676
+++L S AL ++ LLLF +F + FGM F Y ++ ID ++ F +
Sbjct: 1646 LFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA--YVKWEAGID-----DMFNFQTFAN 1698
Query: 677 SFLNVFRILCGEWVETLWDCMEVAGQSWCIP--------------------FYLMVILIG 716
S L +F+I + L + G +C P F+ I+I
Sbjct: 1699 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIIS 1758
Query: 717 NLLVLYLFLALV-SSFSSCKDVTAEENNE 744
L+V+ +++A++ +FS V EE+ E
Sbjct: 1759 FLIVVNMYIAIILENFS----VATEESTE 1783
Score = 67.8 bits (164), Expect = 9e-11
Identities = 59/240 (24%), Positives = 107/240 (44%), Gaps = 11/240 (4%)
Query: 854 QSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGA 913
Q+ DG + +Q + S S + A+ E EE S+H C + L Q
Sbjct: 646 QAPCVDGFEEPGARQRALSAVSVLTSALEELEE-------SRHKCPPC--WNRLAQRYLI 696
Query: 914 SKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADM 973
+ +W +I++ +V + + I + +L+T +A E M + +L+ ++
Sbjct: 697 WECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNL 754
Query: 974 IFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLR 1033
+FT IF EM K +A YF GW D ++VI+ + L L L S + LR
Sbjct: 755 VFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLR 814
Query: 1034 PLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSG 1093
++ + + +++ + + N+ LV +I IF+++G+ LF + E D SG
Sbjct: 815 VFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSG 874
Score = 51.6 bits (122), Expect = 6e-06
Identities = 69/351 (19%), Positives = 146/351 (41%), Gaps = 67/351 (19%)
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
IR+ KI+ ++ F I + T+L+ ++M Q +Y + FT I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLI-MCTILTNC------VFMAQHDPPP-WTKYVEYTFTAIYTFE 171
Query: 983 MLLKWMAYGFK----AYFSNGWYRLDF-VVVIVFCLSLIGKTREELKPLISMKFLRPLRV 1037
L+K +A GF + + W LDF V+++ + + + L + + LR L+
Sbjct: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGN--VSALRTFRVLRALKT 229
Query: 1038 LSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG-------RFYECIDP 1090
+S +K +V ALI++ +V ++ + +F+++G+ LF G R + ++
Sbjct: 230 ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
Query: 1091 TSGE---------------RFPSSEVMNKSRCESLLFNES-------------MLWEN-- 1120
T+G P + ++ + LL S EN
Sbjct: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
Query: 1121 -AKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIF 1179
+FD+ FL+L ++ T + W + + S IYM +F+ I
Sbjct: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFMLVIFL 399
Query: 1180 GVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQ 1230
G F +++++ V+ + + + I T ++ K+++ +++ ++ +
Sbjct: 400 GSFYLVNLILAVVAMAYEEQ----NQATIAETEEKEKRFQEAMEMLKKEHE 446
Score = 49.7 bits (117), Expect = 2e-05
Identities = 54/235 (22%), Positives = 93/235 (39%), Gaps = 43/235 (18%)
Query: 454 EDATLRHKEELEKSKKICPLY-----------------WYKFAKTFLIWNCSPCWLKLKE 496
E+ R + +L+ SKK+ LY +Y KTF++ N +
Sbjct: 48 EEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSA 107
Query: 497 FVHRIIMAPFTDL--------------FLIICIILNVCFLTLEHYPMSKQTNTLLNIGNL 542
+++PF + LI+C IL C +H P
Sbjct: 108 TNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP-----PPWTKYVEY 162
Query: 543 VFIGIFTAEMIFKIIA----MHPYGYFQVGWNIFD-SMIVFHGLIELCLANVAGMALLRL 597
F I+T E + KI+A +H + + + WN D S+I+ E ++ ++ LR
Sbjct: 163 TFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTE--FVDLGNVSALRT 220
Query: 598 FRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
FR+LR K + ++ +L S L D+++L + A G++LF N
Sbjct: 221 FRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGN 275
Score = 45.4 bits (106), Expect = 5e-04
Identities = 34/156 (21%), Positives = 74/156 (47%), Gaps = 11/156 (7%)
Query: 114 VLVHPFFQLFILISVLIDCVFMSL------TNLPKWRPVLENTLLGIYTFEILVKLFARG 167
V++ PF L I + ++++ +FM+L + + V GI+T E+ K+ A
Sbjct: 713 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA-- 770
Query: 168 VWAGSFSFLGDPWNWLDFSVTVFEVI-IRYSPLDFIPTLQTARTLRILKIIPLNQGLKSL 226
+ + WN D + + ++ + S + + L++ R LR+ K+ L +L
Sbjct: 771 --LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTL 828
Query: 227 VGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGN 262
+ ++ + + L + ++ + IF+++GM LF N
Sbjct: 829 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864
Score = 34.7 bits (78), Expect = 0.80
Identities = 33/172 (19%), Positives = 70/172 (40%), Gaps = 20/172 (11%)
Query: 1236 PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYT 1295
P + ++ ++ FN+++M I + M + ++ F +YT
Sbjct: 116 PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTK------YVEYTFTAIYT 169
Query: 1296 MECILKLIA--FRCFYFTIA---WNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILL 1350
E ++K++A F FT WN DF V+I + T + V V +
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYT---------TEFVDLGNVSALRT 220
Query: 1351 SRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF 1402
R++ L+ ++ L+ S+ L ++++L + ++A+ G+ F
Sbjct: 221 FRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
sapiens]
Length = 2016
Score = 1121 bits (2900), Expect = 0.0
Identities = 605/1259 (48%), Positives = 825/1259 (65%), Gaps = 78/1259 (6%)
Query: 462 EELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCF 521
EELE+S+ CP W + A+ +LIW C P W+ +K+ V ++M PFTDL + +CI+LN F
Sbjct: 674 EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLF 733
Query: 522 LTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGL 581
+ LEHY M+ + +L +GNLVF GIFTAEM FKIIA+ PY YFQ GWNIFDS+IV L
Sbjct: 734 MALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSL 793
Query: 582 IELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFS 641
+EL L+ ++ +++LR FR+LR+FKL K WPT L+ + NS AL +L L+L +F
Sbjct: 794 MELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIF 853
Query: 642 AAFGMKLFGKNYEEFVCHIDKDC-QLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVA 700
A GM+LFGKNY E D D LPRWHM DFFH+FL +FRILCGEW+ET+WDCMEV+
Sbjct: 854 AVVGMQLFGKNYSEL---RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVS 910
Query: 701 GQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTA-EENNEAKNLQLAVARIKKGI 759
GQS C+ +L+V++IGNL+VL LFLAL+ S S ++TA +E+ E NLQLA+ARI++G+
Sbjct: 911 GQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGL 970
Query: 760 NYV---LLKILC--------------------------------KTQNVP---KDTMDHV 781
+V C +T+ VP K+T
Sbjct: 971 RFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEE 1030
Query: 782 NEVYVKEDISDH-----TLSELSNTQDFLKDKEKSS-GTEKNAT-ENESQSLIPSPSVSE 834
E + D ++ + D ++ E++S GTE+ ++ + ESQ + P E
Sbjct: 1031 GEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGP---E 1087
Query: 835 TVPIASGESDIENLDNKEIQSKSGDGGSKEKIK------------QSSSSECSTVDIAIS 882
P + S + + E ++ + +++ K + S SE ST D+ +
Sbjct: 1088 APPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNT 1147
Query: 883 EE--EEMFYGGERSKH----LKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWF 936
E E++ G+ K GC R + GK+W +RKTC IVE++WF
Sbjct: 1148 AELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWF 1207
Query: 937 KCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYF 996
+ FI + LLS+G LAFEDIY+++RKTIK+LLEYAD +FTY+F+LEMLLKW+AYGFK YF
Sbjct: 1208 ETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYF 1267
Query: 997 SNGWYRLDFVVVIVFCLSLIGKT-----REELKPLISMKFLRPLRVLSQFERMKVVVRAL 1051
+N W LDF++V V +SL+ T +K L +++ LRPLR LS+FE M+VVV AL
Sbjct: 1268 TNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNAL 1327
Query: 1052 IKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGE-RFPSSEVMNKSRCESL 1110
+ +NV LVCL+ WLIFSIMGV+LFAG+F CI+ T G+ + V NKS+CESL
Sbjct: 1328 VGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESL 1387
Query: 1111 LFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMY 1170
+ W K+NFDNVG G+L+LLQVATF GW+ IM +A+DS QP +E N+YMY
Sbjct: 1388 NLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMY 1447
Query: 1171 CYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQ 1230
YF+ FIIFG F L++ I VIIDNFN+ K KLGG +IF+T +Q+K Y +KKL + Q
Sbjct: 1448 IYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ 1507
Query: 1231 RPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIF 1290
+P+PRPLNK QGFIFD+VT QAF+V +M LIC + MM++TD QS + L IN +F
Sbjct: 1508 KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLF 1567
Query: 1291 VMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILL 1350
V ++T ECI+KL A R +YFT +WNIFDF+VVI SI G L + Y P+L ++I L
Sbjct: 1568 VAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1627
Query: 1351 SRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAG 1410
+RI +LRL +G K L+ LM+SLPAL NI LL+FLVMFIY++FGM NFAYVK EAG
Sbjct: 1628 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAG 1687
Query: 1411 INDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPS 1470
I+D+ NF+TF NSMLCLFQ+ AGWDG+L I N+ CDP N RGDCG+P+
Sbjct: 1688 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPA 1746
Query: 1471 VGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRT 1530
VGI +F +YI+IS+LI+VNMYI +++E ++A+++ + LSEDDF F+++W++FDP+ T
Sbjct: 1747 VGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEAT 1806
Query: 1531 QYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDV 1590
Q+I+ S LSDFA AL PL +AKPN+ LI +DLPM GDRIHC+DIL AFTKRV+G+
Sbjct: 1807 QFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESG 1866
Query: 1591 RMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTS 1649
M+ + ++E F+ ANP KI+ EPITTTL+RK E VSA +IQRA++ + L+R+ K+ S
Sbjct: 1867 EMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHAS 1925
Score = 383 bits (983), Expect = e-106
Identities = 209/463 (45%), Positives = 286/463 (61%), Gaps = 36/463 (7%)
Query: 13 FTKESFELIKQHIAK-------THNEDHE----EEDLKPTPDLEVGKKLPFIYGNLSQGM 61
FT+ES I++ +A+ T E E EE +P DL+ KKLP +YGN Q +
Sbjct: 16 FTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQEL 75
Query: 62 VSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQ 121
+ EPLED+DP+Y +K TFIVLNK +TIFRF+A + L LSPF+ IRR +K+LVH F
Sbjct: 76 IGEPLEDLDPFYSTQK-TFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFN 134
Query: 122 LFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWN 181
+ I+ ++L +CVFM+ + P W +E T IYTFE LVK+ ARG +F+FL DPWN
Sbjct: 135 MLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWN 194
Query: 182 WLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVI 241
WLDFSV + + L + L+T R LR LK I + GLK++VG LI +K+L V+
Sbjct: 195 WLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVM 254
Query: 242 ILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGN------------PYYI 289
+LT+F LS+F+LIG+ LFMGNL+HKC R N T N T Y+
Sbjct: 255 VLTVFCLSVFALIGLQLFMGNLRHKCVR------NFTALNGTNGSVEADGLVWESLDLYL 308
Query: 290 RETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRL 349
+ EN+ G LLCGN +DAG CPEGY C+KAG NPD G+T+FDSF WA ALFRL
Sbjct: 309 SDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRL 368
Query: 350 MAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISK 409
M QD E LY Q L ++GK+YMIFF++V FL SFY+ +L L ++AMAYEE+ Q ++
Sbjct: 369 MTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
Query: 410 KIEPKFQQTGKELQEGNE------TDEAKTIQIEMKKRSPIST 446
+ E +FQ+ + L++ +E D +EM +P+++
Sbjct: 429 EKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNS 471
Score = 132 bits (332), Expect = 3e-30
Identities = 154/689 (22%), Positives = 291/689 (42%), Gaps = 149/689 (21%)
Query: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNL----PKWRPVLENTLLGIYTFEILVK 162
+R+T ++ H +F+ FI+ +L+ ++ ++ K VL ++T+ +++
Sbjct: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253
Query: 163 LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216
+ + V G + + W WLDF + ++ + ++ + I +L+T R LR L+
Sbjct: 1254 MLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRA 1313
Query: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQ---- 272
+ +G++ +V L+ + ++ V+++ L F IFS++G+ LF G +C +
Sbjct: 1314 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCINQTEGDLP 1372
Query: 273 --------ENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVK 324
+++ E+L N TG Y+ + NF + G Y L T G Y V
Sbjct: 1373 LNYTIVNNKSQCESL-NLTGELYWTKVKVNFDNV-GAGYLALLQVATFKGWMDIMYAAV- 1429
Query: 325 AGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFY 384
DS G+ ++ P+ Y+ +Y I+FV+ SF+
Sbjct: 1430 ------------DSRGY----------EEQPQWEYNLYMY-------IYFVIFIIFGSFF 1460
Query: 385 MASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPI 444
+LF+G++ + ++K+++G Q+ T+E K MKK
Sbjct: 1461 TLNLFIGVIIDNFNQQKKKLGG----------------QDIFMTEEQKKYYNAMKKLGS- 1503
Query: 445 STDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMA 504
+K +K P K+ + F+ I+
Sbjct: 1504 --------------------KKPQKPIPRPLNKY----------------QGFIFDIVTK 1527
Query: 505 PFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGY 564
D+ ++ I LN+ + +E S + +L NL+F+ IFT E I K+ A+ Y Y
Sbjct: 1528 QAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHY-Y 1586
Query: 565 FQVGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQIL 616
F WNIFD ++V ++ L+++ ++RL R+ RI +L + + L
Sbjct: 1587 FTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTL 1646
Query: 617 MWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFH 676
+++L S AL ++ LLLF +F + FGM F Y ++ ID ++ F +
Sbjct: 1647 LFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA--YVKWEAGID-----DMFNFQTFAN 1699
Query: 677 SFLNVFRILCGEWVETLWDCMEVAGQSWCIP--------------------FYLMVILIG 716
S L +F+I + L + G +C P F+ I+I
Sbjct: 1700 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIIS 1759
Query: 717 NLLVLYLFLALV-SSFSSCKDVTAEENNE 744
L+V+ +++A++ +FS V EE+ E
Sbjct: 1760 FLIVVNMYIAIILENFS----VATEESTE 1784
Score = 67.8 bits (164), Expect = 9e-11
Identities = 59/240 (24%), Positives = 107/240 (44%), Gaps = 11/240 (4%)
Query: 854 QSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGA 913
Q+ DG + +Q + S S + A+ E EE S+H C + L Q
Sbjct: 646 QAPCVDGFEEPGARQRALSAVSVLTSALEELEE-------SRHKCPPC--WNRLAQRYLI 696
Query: 914 SKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADM 973
+ +W +I++ +V + + I + +L+T +A E M + +L+ ++
Sbjct: 697 WECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNL 754
Query: 974 IFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLR 1033
+FT IF EM K +A YF GW D ++VI+ + L L L S + LR
Sbjct: 755 VFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLR 814
Query: 1034 PLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSG 1093
++ + + +++ + + N+ LV +I IF+++G+ LF + E D SG
Sbjct: 815 VFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSG 874
Score = 51.6 bits (122), Expect = 6e-06
Identities = 69/351 (19%), Positives = 146/351 (41%), Gaps = 67/351 (19%)
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
IR+ KI+ ++ F I + T+L+ ++M Q +Y + FT I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLI-MCTILTNC------VFMAQHDPPP-WTKYVEYTFTAIYTFE 171
Query: 983 MLLKWMAYGFK----AYFSNGWYRLDF-VVVIVFCLSLIGKTREELKPLISMKFLRPLRV 1037
L+K +A GF + + W LDF V+++ + + + L + + LR L+
Sbjct: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGN--VSALRTFRVLRALKT 229
Query: 1038 LSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG-------RFYECIDP 1090
+S +K +V ALI++ +V ++ + +F+++G+ LF G R + ++
Sbjct: 230 ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
Query: 1091 TSGE---------------RFPSSEVMNKSRCESLLFNES-------------MLWEN-- 1120
T+G P + ++ + LL S EN
Sbjct: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
Query: 1121 -AKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIF 1179
+FD+ FL+L ++ T + W + + S IYM +F+ I
Sbjct: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFMLVIFL 399
Query: 1180 GVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQ 1230
G F +++++ V+ + + + I T ++ K+++ +++ ++ +
Sbjct: 400 GSFYLVNLILAVVAMAYEEQ----NQATIAETEEKEKRFQEAMEMLKKEHE 446
Score = 49.7 bits (117), Expect = 2e-05
Identities = 54/235 (22%), Positives = 93/235 (39%), Gaps = 43/235 (18%)
Query: 454 EDATLRHKEELEKSKKICPLY-----------------WYKFAKTFLIWNCSPCWLKLKE 496
E+ R + +L+ SKK+ LY +Y KTF++ N +
Sbjct: 48 EEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSA 107
Query: 497 FVHRIIMAPFTDL--------------FLIICIILNVCFLTLEHYPMSKQTNTLLNIGNL 542
+++PF + LI+C IL C +H P
Sbjct: 108 TNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP-----PPWTKYVEY 162
Query: 543 VFIGIFTAEMIFKIIA----MHPYGYFQVGWNIFD-SMIVFHGLIELCLANVAGMALLRL 597
F I+T E + KI+A +H + + + WN D S+I+ E ++ ++ LR
Sbjct: 163 TFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTE--FVDLGNVSALRT 220
Query: 598 FRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
FR+LR K + ++ +L S L D+++L + A G++LF N
Sbjct: 221 FRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGN 275
Score = 45.4 bits (106), Expect = 5e-04
Identities = 34/156 (21%), Positives = 74/156 (47%), Gaps = 11/156 (7%)
Query: 114 VLVHPFFQLFILISVLIDCVFMSL------TNLPKWRPVLENTLLGIYTFEILVKLFARG 167
V++ PF L I + ++++ +FM+L + + V GI+T E+ K+ A
Sbjct: 713 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA-- 770
Query: 168 VWAGSFSFLGDPWNWLDFSVTVFEVI-IRYSPLDFIPTLQTARTLRILKIIPLNQGLKSL 226
+ + WN D + + ++ + S + + L++ R LR+ K+ L +L
Sbjct: 771 --LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTL 828
Query: 227 VGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGN 262
+ ++ + + L + ++ + IF+++GM LF N
Sbjct: 829 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864
Score = 34.7 bits (78), Expect = 0.80
Identities = 33/172 (19%), Positives = 70/172 (40%), Gaps = 20/172 (11%)
Query: 1236 PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYT 1295
P + ++ ++ FN+++M I + M + ++ F +YT
Sbjct: 116 PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTK------YVEYTFTAIYT 169
Query: 1296 MECILKLIA--FRCFYFTIA---WNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILL 1350
E ++K++A F FT WN DF V+I + T + V V +
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYT---------TEFVDLGNVSALRT 220
Query: 1351 SRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF 1402
R++ L+ ++ L+ S+ L ++++L + ++A+ G+ F
Sbjct: 221 FRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
>gi|150417967 voltage-gated sodium channel type V alpha isoform c
[Homo sapiens]
Length = 2016
Score = 1121 bits (2900), Expect = 0.0
Identities = 605/1259 (48%), Positives = 825/1259 (65%), Gaps = 78/1259 (6%)
Query: 462 EELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCF 521
EELE+S+ CP W + A+ +LIW C P W+ +K+ V ++M PFTDL + +CI+LN F
Sbjct: 674 EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLF 733
Query: 522 LTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGL 581
+ LEHY M+ + +L +GNLVF GIFTAEM FKIIA+ PY YFQ GWNIFDS+IV L
Sbjct: 734 MALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSL 793
Query: 582 IELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFS 641
+EL L+ ++ +++LR FR+LR+FKL K WPT L+ + NS AL +L L+L +F
Sbjct: 794 MELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIF 853
Query: 642 AAFGMKLFGKNYEEFVCHIDKDC-QLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVA 700
A GM+LFGKNY E D D LPRWHM DFFH+FL +FRILCGEW+ET+WDCMEV+
Sbjct: 854 AVVGMQLFGKNYSEL---RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVS 910
Query: 701 GQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTA-EENNEAKNLQLAVARIKKGI 759
GQS C+ +L+V++IGNL+VL LFLAL+ S S ++TA +E+ E NLQLA+ARI++G+
Sbjct: 911 GQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGL 970
Query: 760 NYV---LLKILC--------------------------------KTQNVP---KDTMDHV 781
+V C +T+ VP K+T
Sbjct: 971 RFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEE 1030
Query: 782 NEVYVKEDISDH-----TLSELSNTQDFLKDKEKSS-GTEKNAT-ENESQSLIPSPSVSE 834
E + D ++ + D ++ E++S GTE+ ++ + ESQ + P E
Sbjct: 1031 GEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGP---E 1087
Query: 835 TVPIASGESDIENLDNKEIQSKSGDGGSKEKIK------------QSSSSECSTVDIAIS 882
P + S + + E ++ + +++ K + S SE ST D+ +
Sbjct: 1088 APPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNT 1147
Query: 883 EE--EEMFYGGERSKH----LKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWF 936
E E++ G+ K GC R + GK+W +RKTC IVE++WF
Sbjct: 1148 AELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWF 1207
Query: 937 KCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYF 996
+ FI + LLS+G LAFEDIY+++RKTIK+LLEYAD +FTY+F+LEMLLKW+AYGFK YF
Sbjct: 1208 ETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYF 1267
Query: 997 SNGWYRLDFVVVIVFCLSLIGKT-----REELKPLISMKFLRPLRVLSQFERMKVVVRAL 1051
+N W LDF++V V +SL+ T +K L +++ LRPLR LS+FE M+VVV AL
Sbjct: 1268 TNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNAL 1327
Query: 1052 IKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGE-RFPSSEVMNKSRCESL 1110
+ +NV LVCL+ WLIFSIMGV+LFAG+F CI+ T G+ + V NKS+CESL
Sbjct: 1328 VGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESL 1387
Query: 1111 LFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMY 1170
+ W K+NFDNVG G+L+LLQVATF GW+ IM +A+DS QP +E N+YMY
Sbjct: 1388 NLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMY 1447
Query: 1171 CYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQ 1230
YF+ FIIFG F L++ I VIIDNFN+ K KLGG +IF+T +Q+K Y +KKL + Q
Sbjct: 1448 IYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ 1507
Query: 1231 RPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIF 1290
+P+PRPLNK QGFIFD+VT QAF+V +M LIC + MM++TD QS + L IN +F
Sbjct: 1508 KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLF 1567
Query: 1291 VMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILL 1350
V ++T ECI+KL A R +YFT +WNIFDF+VVI SI G L + Y P+L ++I L
Sbjct: 1568 VAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1627
Query: 1351 SRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAG 1410
+RI +LRL +G K L+ LM+SLPAL NI LL+FLVMFIY++FGM NFAYVK EAG
Sbjct: 1628 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAG 1687
Query: 1411 INDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPS 1470
I+D+ NF+TF NSMLCLFQ+ AGWDG+L I N+ CDP N RGDCG+P+
Sbjct: 1688 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPA 1746
Query: 1471 VGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRT 1530
VGI +F +YI+IS+LI+VNMYI +++E ++A+++ + LSEDDF F+++W++FDP+ T
Sbjct: 1747 VGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEAT 1806
Query: 1531 QYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDV 1590
Q+I+ S LSDFA AL PL +AKPN+ LI +DLPM GDRIHC+DIL AFTKRV+G+
Sbjct: 1807 QFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESG 1866
Query: 1591 RMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTS 1649
M+ + ++E F+ ANP KI+ EPITTTL+RK E VSA +IQRA++ + L+R+ K+ S
Sbjct: 1867 EMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHAS 1925
Score = 381 bits (979), Expect = e-105
Identities = 209/463 (45%), Positives = 286/463 (61%), Gaps = 36/463 (7%)
Query: 13 FTKESFELIKQHIAK-------THNEDHE----EEDLKPTPDLEVGKKLPFIYGNLSQGM 61
FT+ES I++ +A+ T E E EE +P DL+ KKLP +YGN Q +
Sbjct: 16 FTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQEL 75
Query: 62 VSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQ 121
+ EPLED+DP+Y +K TFIVLNK +TIFRF+A + L LSPF+ IRR +K+LVH F
Sbjct: 76 IGEPLEDLDPFYSTQK-TFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFN 134
Query: 122 LFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWN 181
+ I+ ++L +CVFM+ + P W +E T IYTFE LVK+ ARG +F+FL DPWN
Sbjct: 135 MLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWN 194
Query: 182 WLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVI 241
WLDFSV + + L + L+T R LR LK I + GLK++VG LI +K+L V+
Sbjct: 195 WLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVM 254
Query: 242 ILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGN------------PYYI 289
+LT+F LS+F+LIG+ LFMGNL+HKC R N T N T Y+
Sbjct: 255 VLTVFCLSVFALIGLQLFMGNLRHKCVR------NFTALNGTNGSVEADGLVWESLDLYL 308
Query: 290 RETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRL 349
+ EN+ G LLCGN +DAG CPEGY C+KAG NPD G+T+FDSF WA ALFRL
Sbjct: 309 SDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRL 368
Query: 350 MAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISK 409
M QD E LY Q L ++GK+YMIFF++V FL SFY+ +L L ++AMAYEE+ Q ++
Sbjct: 369 MTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
Query: 410 KIEPKFQQTGKELQEGNE------TDEAKTIQIEMKKRSPIST 446
+ E +FQ+ + L++ +E D +EM +P+++
Sbjct: 429 EKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNS 471
Score = 132 bits (332), Expect = 3e-30
Identities = 154/689 (22%), Positives = 291/689 (42%), Gaps = 149/689 (21%)
Query: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNL----PKWRPVLENTLLGIYTFEILVK 162
+R+T ++ H +F+ FI+ +L+ ++ ++ K VL ++T+ +++
Sbjct: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253
Query: 163 LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216
+ + V G + + W WLDF + ++ + ++ + I +L+T R LR L+
Sbjct: 1254 MLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRA 1313
Query: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQ---- 272
+ +G++ +V L+ + ++ V+++ L F IFS++G+ LF G +C +
Sbjct: 1314 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCINQTEGDLP 1372
Query: 273 --------ENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVK 324
+++ E+L N TG Y+ + NF + G Y L T G Y V
Sbjct: 1373 LNYTIVNNKSQCESL-NLTGELYWTKVKVNFDNV-GAGYLALLQVATFKGWMDIMYAAV- 1429
Query: 325 AGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFY 384
DS G+ ++ P+ Y+ +Y I+FV+ SF+
Sbjct: 1430 ------------DSRGY----------EEQPQWEYNLYMY-------IYFVIFIIFGSFF 1460
Query: 385 MASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPI 444
+LF+G++ + ++K+++G Q+ T+E K MKK
Sbjct: 1461 TLNLFIGVIIDNFNQQKKKLGG----------------QDIFMTEEQKKYYNAMKKLGS- 1503
Query: 445 STDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMA 504
+K +K P K+ + F+ I+
Sbjct: 1504 --------------------KKPQKPIPRPLNKY----------------QGFIFDIVTK 1527
Query: 505 PFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGY 564
D+ ++ I LN+ + +E S + +L NL+F+ IFT E I K+ A+ Y Y
Sbjct: 1528 QAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHY-Y 1586
Query: 565 FQVGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQIL 616
F WNIFD ++V ++ L+++ ++RL R+ RI +L + + L
Sbjct: 1587 FTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTL 1646
Query: 617 MWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFH 676
+++L S AL ++ LLLF +F + FGM F Y ++ ID ++ F +
Sbjct: 1647 LFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA--YVKWEAGID-----DMFNFQTFAN 1699
Query: 677 SFLNVFRILCGEWVETLWDCMEVAGQSWCIP--------------------FYLMVILIG 716
S L +F+I + L + G +C P F+ I+I
Sbjct: 1700 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIIS 1759
Query: 717 NLLVLYLFLALV-SSFSSCKDVTAEENNE 744
L+V+ +++A++ +FS V EE+ E
Sbjct: 1760 FLIVVNMYIAIILENFS----VATEESTE 1784
Score = 67.8 bits (164), Expect = 9e-11
Identities = 59/240 (24%), Positives = 107/240 (44%), Gaps = 11/240 (4%)
Query: 854 QSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGA 913
Q+ DG + +Q + S S + A+ E EE S+H C + L Q
Sbjct: 646 QAPCVDGFEEPGARQRALSAVSVLTSALEELEE-------SRHKCPPC--WNRLAQRYLI 696
Query: 914 SKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADM 973
+ +W +I++ +V + + I + +L+T +A E M + +L+ ++
Sbjct: 697 WECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNL 754
Query: 974 IFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLR 1033
+FT IF EM K +A YF GW D ++VI+ + L L L S + LR
Sbjct: 755 VFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLR 814
Query: 1034 PLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSG 1093
++ + + +++ + + N+ LV +I IF+++G+ LF + E D SG
Sbjct: 815 VFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSG 874
Score = 54.7 bits (130), Expect = 7e-07
Identities = 73/350 (20%), Positives = 147/350 (42%), Gaps = 65/350 (18%)
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
IR+ KI+ ++ F I + T+L+ ++M Q +Y + FT I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLI-MCTILTNC------VFMAQHDPPP-WTKYVEYTFTAIYTFE 171
Query: 983 MLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038
L+K +A GF + + W LDF V+I+ +S K L L + + LR L+ +
Sbjct: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGN-LSALRTFRVLRALKTI 230
Query: 1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG-------RFYECIDPT 1091
S +K +V ALI++ +V ++ + +F+++G+ LF G R + ++ T
Sbjct: 231 SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGT 290
Query: 1092 SGE---------------RFPSSEVMNKSRCESLLFNES-------------MLWEN--- 1120
+G P + ++ + LL S EN
Sbjct: 291 NGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDH 350
Query: 1121 AKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFG 1180
+FD+ FL+L ++ T + W + + S IYM +F+ I G
Sbjct: 351 GYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFMLVIFLG 400
Query: 1181 VFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQ 1230
F +++++ V+ + + + I T ++ K+++ +++ ++ +
Sbjct: 401 SFYLVNLILAVVAMAYEEQ----NQATIAETEEKEKRFQEAMEMLKKEHE 446
Score = 53.5 bits (127), Expect = 2e-06
Identities = 52/234 (22%), Positives = 92/234 (39%), Gaps = 41/234 (17%)
Query: 454 EDATLRHKEELEKSKKICPLY-----------------WYKFAKTFLIWNCSPCWLKLKE 496
E+ R + +L+ SKK+ LY +Y KTF++ N +
Sbjct: 48 EEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSA 107
Query: 497 FVHRIIMAPFTDL--------------FLIICIILNVCFLTLEHYPMSKQTNTLLNIGNL 542
+++PF + LI+C IL C +H P
Sbjct: 108 TNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP-----PPWTKYVEY 162
Query: 543 VFIGIFTAEMIFKIIA----MHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLF 598
F I+T E + KI+A +H + + + WN D ++ + + + ++ LR F
Sbjct: 163 TFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENI-KLGNLSALRTF 221
Query: 599 RMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
R+LR K P + ++ +L S L D+++L + A G++LF N
Sbjct: 222 RVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGN 275
Score = 45.4 bits (106), Expect = 5e-04
Identities = 34/156 (21%), Positives = 74/156 (47%), Gaps = 11/156 (7%)
Query: 114 VLVHPFFQLFILISVLIDCVFMSL------TNLPKWRPVLENTLLGIYTFEILVKLFARG 167
V++ PF L I + ++++ +FM+L + + V GI+T E+ K+ A
Sbjct: 713 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA-- 770
Query: 168 VWAGSFSFLGDPWNWLDFSVTVFEVI-IRYSPLDFIPTLQTARTLRILKIIPLNQGLKSL 226
+ + WN D + + ++ + S + + L++ R LR+ K+ L +L
Sbjct: 771 --LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTL 828
Query: 227 VGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGN 262
+ ++ + + L + ++ + IF+++GM LF N
Sbjct: 829 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864
>gi|150417969 voltage-gated sodium channel type V alpha isoform d
[Homo sapiens]
Length = 1998
Score = 1089 bits (2817), Expect = 0.0
Identities = 595/1259 (47%), Positives = 812/1259 (64%), Gaps = 96/1259 (7%)
Query: 462 EELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCF 521
EELE+S+ CP W + A+ +LIW C P W+ +K+ V ++M PFTDL + +CI+LN F
Sbjct: 674 EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLF 733
Query: 522 LTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGL 581
+ LEHY M+ + +L +GNLVF GIFTAEM FKIIA+ PY YFQ GWNIFDS+IV L
Sbjct: 734 MALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSL 793
Query: 582 IELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFS 641
+EL L+ ++ +++LR FR+LR+FKL K WPT L+ + NS AL +L L+L +F
Sbjct: 794 MELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIF 853
Query: 642 AAFGMKLFGKNYEEFVCHIDKDC-QLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVA 700
A GM+LFGKNY E D D LPRWHM DFFH+FL +FRILCGEW+ET+WDCMEV+
Sbjct: 854 AVVGMQLFGKNYSEL---RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVS 910
Query: 701 GQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTA-EENNEAKNLQLAVARIKKGI 759
GQS C+ +L+V++IGNL+VL LFLAL+ S S ++TA +E+ E NLQLA+ARI++G+
Sbjct: 911 GQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGL 970
Query: 760 NYV---LLKILC--------------------------------KTQNVP---KDTMDHV 781
+V C +T+ VP K+T
Sbjct: 971 RFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEE 1030
Query: 782 NEVYVKEDISDH-----TLSELSNTQDFLKDKEKSS-GTEKNAT-ENESQSLIPSPSVSE 834
E + D ++ + D ++ E++S GTE+ ++ + ESQ + P E
Sbjct: 1031 GEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGP---E 1087
Query: 835 TVPIASGESDIENLDNKEIQSKSGDGGSKEKIK------------QSSSSECSTVDIAIS 882
P + S + + E ++ + +++ K + S SE ST D+ +
Sbjct: 1088 APPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNT 1147
Query: 883 EE--EEMFYGGERSKH----LKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWF 936
E E++ G+ K GC R + GK+W +RKTC IVE++WF
Sbjct: 1148 AELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWF 1207
Query: 937 KCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYF 996
+ FI + LLS+G LAFEDIY+++RKTIK+LLEYAD +FTY+F+LEMLLKW+AYGFK YF
Sbjct: 1208 ETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYF 1267
Query: 997 SNGWYRLDFVVVIVFCLSLIGKT-----REELKPLISMKFLRPLRVLSQFERMKVVVRAL 1051
+N W LDF++V V +SL+ T +K L +++ LRPLR LS+FE M+VVV AL
Sbjct: 1268 TNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNAL 1327
Query: 1052 IKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGE-RFPSSEVMNKSRCESL 1110
+ +NV LVCL+ WLIFSIMGV+LFAG+F CI+ T G+ + V NKS+CESL
Sbjct: 1328 VGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESL 1387
Query: 1111 LFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMY 1170
+ W K+NFDNVG G+L+LLQV QP +E N+YMY
Sbjct: 1388 NLTGELYWTKVKVNFDNVGAGYLALLQV------------------YEEQPQWEYNLYMY 1429
Query: 1171 CYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQ 1230
YF+ FIIFG F L++ I VIIDNFN+ K KLGG +IF+T +Q+K Y +KKL + Q
Sbjct: 1430 IYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ 1489
Query: 1231 RPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIF 1290
+P+PRPLNK QGFIFD+VT QAF+V +M LIC + MM++TD QS + L IN +F
Sbjct: 1490 KPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLF 1549
Query: 1291 VMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILL 1350
V ++T ECI+KL A R +YFT +WNIFDF+VVI SI G L + Y P+L ++I L
Sbjct: 1550 VAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1609
Query: 1351 SRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAG 1410
+RI +LRL +G K L+ LM+SLPAL NI LL+FLVMFIY++FGM NFAYVK EAG
Sbjct: 1610 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAG 1669
Query: 1411 INDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPS 1470
I+D+ NF+TF NSMLCLFQ+ AGWDG+L I N+ CDP N RGDCG+P+
Sbjct: 1670 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPA 1728
Query: 1471 VGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRT 1530
VGI +F +YI+IS+LI+VNMYI +++E ++A+++ + LSEDDF F+++W++FDP+ T
Sbjct: 1729 VGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEAT 1788
Query: 1531 QYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDV 1590
Q+I+ S LSDFA AL PL +AKPN+ LI +DLPM GDRIHC+DIL AFTKRV+G+
Sbjct: 1789 QFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESG 1848
Query: 1591 RMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTS 1649
M+ + ++E F+ ANP KI+ EPITTTL+RK E VSA +IQRA++ + L+R+ K+ S
Sbjct: 1849 EMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHAS 1907
Score = 381 bits (979), Expect = e-105
Identities = 209/463 (45%), Positives = 286/463 (61%), Gaps = 36/463 (7%)
Query: 13 FTKESFELIKQHIAK-------THNEDHE----EEDLKPTPDLEVGKKLPFIYGNLSQGM 61
FT+ES I++ +A+ T E E EE +P DL+ KKLP +YGN Q +
Sbjct: 16 FTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQEL 75
Query: 62 VSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQ 121
+ EPLED+DP+Y +K TFIVLNK +TIFRF+A + L LSPF+ IRR +K+LVH F
Sbjct: 76 IGEPLEDLDPFYSTQK-TFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFN 134
Query: 122 LFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWN 181
+ I+ ++L +CVFM+ + P W +E T IYTFE LVK+ ARG +F+FL DPWN
Sbjct: 135 MLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWN 194
Query: 182 WLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVI 241
WLDFSV + + L + L+T R LR LK I + GLK++VG LI +K+L V+
Sbjct: 195 WLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVM 254
Query: 242 ILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGN------------PYYI 289
+LT+F LS+F+LIG+ LFMGNL+HKC R N T N T Y+
Sbjct: 255 VLTVFCLSVFALIGLQLFMGNLRHKCVR------NFTALNGTNGSVEADGLVWESLDLYL 308
Query: 290 RETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRL 349
+ EN+ G LLCGN +DAG CPEGY C+KAG NPD G+T+FDSF WA ALFRL
Sbjct: 309 SDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRL 368
Query: 350 MAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISK 409
M QD E LY Q L ++GK+YMIFF++V FL SFY+ +L L ++AMAYEE+ Q ++
Sbjct: 369 MTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
Query: 410 KIEPKFQQTGKELQEGNE------TDEAKTIQIEMKKRSPIST 446
+ E +FQ+ + L++ +E D +EM +P+++
Sbjct: 429 EKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNS 471
Score = 132 bits (332), Expect = 3e-30
Identities = 147/679 (21%), Positives = 285/679 (41%), Gaps = 147/679 (21%)
Query: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNL----PKWRPVLENTLLGIYTFEILVK 162
+R+T ++ H +F+ FI+ +L+ ++ ++ K VL ++T+ +++
Sbjct: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253
Query: 163 LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216
+ + V G + + W WLDF + ++ + ++ + I +L+T R LR L+
Sbjct: 1254 MLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRA 1313
Query: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQEN-- 274
+ +G++ +V L+ + ++ V+++ L F IFS++G+ LF G +C + +
Sbjct: 1314 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCINQTEGDLP 1372
Query: 275 ENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFT 334
N T+ N + T Y+ + +
Sbjct: 1373 LNYTIVNNKSQCESLNLTGELYWTKVK--------------------------------V 1400
Query: 335 NFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILA 394
NFD+ G AL ++ ++ P+ Y+ +Y I+FV+ SF+ +LF+G++
Sbjct: 1401 NFDNVGAGYLALLQVY-EEQPQWEYNLYMY-------IYFVIFIIFGSFFTLNLFIGVII 1452
Query: 395 MAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLE 454
+ ++K+++G Q+ T+E K MKK
Sbjct: 1453 DNFNQQKKKLGG----------------QDIFMTEEQKKYYNAMKKLGS----------- 1485
Query: 455 DATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIIC 514
+K +K P K+ + F+ I+ D+ ++
Sbjct: 1486 ----------KKPQKPIPRPLNKY----------------QGFIFDIVTKQAFDVTIMFL 1519
Query: 515 IILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDS 574
I LN+ + +E S + +L NL+F+ IFT E I K+ A+ Y YF WNIFD
Sbjct: 1520 ICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHY-YFTNSWNIFDF 1578
Query: 575 MIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVA 626
++V ++ L+++ ++RL R+ RI +L + + L+++L S A
Sbjct: 1579 VVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPA 1638
Query: 627 LKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILC 686
L ++ LLLF +F + FGM F Y ++ ID ++ F +S L +F+I
Sbjct: 1639 LFNIGLLLFLVMFIYSIFGMANFA--YVKWEAGID-----DMFNFQTFANSMLCLFQITT 1691
Query: 687 GEWVETLWDCMEVAGQSWCIP--------------------FYLMVILIGNLLVLYLFLA 726
+ L + G +C P F+ I+I L+V+ +++A
Sbjct: 1692 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIA 1751
Query: 727 LV-SSFSSCKDVTAEENNE 744
++ +FS V EE+ E
Sbjct: 1752 IILENFS----VATEESTE 1766
Score = 67.8 bits (164), Expect = 9e-11
Identities = 59/240 (24%), Positives = 107/240 (44%), Gaps = 11/240 (4%)
Query: 854 QSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGA 913
Q+ DG + +Q + S S + A+ E EE S+H C + L Q
Sbjct: 646 QAPCVDGFEEPGARQRALSAVSVLTSALEELEE-------SRHKCPPC--WNRLAQRYLI 696
Query: 914 SKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADM 973
+ +W +I++ +V + + I + +L+T +A E M + +L+ ++
Sbjct: 697 WECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNL 754
Query: 974 IFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLR 1033
+FT IF EM K +A YF GW D ++VI+ + L L L S + LR
Sbjct: 755 VFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLR 814
Query: 1034 PLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSG 1093
++ + + +++ + + N+ LV +I IF+++G+ LF + E D SG
Sbjct: 815 VFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSG 874
Score = 54.7 bits (130), Expect = 7e-07
Identities = 73/350 (20%), Positives = 147/350 (42%), Gaps = 65/350 (18%)
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
IR+ KI+ ++ F I + T+L+ ++M Q +Y + FT I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLI-MCTILTNC------VFMAQHDPPP-WTKYVEYTFTAIYTFE 171
Query: 983 MLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038
L+K +A GF + + W LDF V+I+ +S K L L + + LR L+ +
Sbjct: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGN-LSALRTFRVLRALKTI 230
Query: 1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG-------RFYECIDPT 1091
S +K +V ALI++ +V ++ + +F+++G+ LF G R + ++ T
Sbjct: 231 SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGT 290
Query: 1092 SGE---------------RFPSSEVMNKSRCESLLFNES-------------MLWEN--- 1120
+G P + ++ + LL S EN
Sbjct: 291 NGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDH 350
Query: 1121 AKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFG 1180
+FD+ FL+L ++ T + W + + S IYM +F+ I G
Sbjct: 351 GYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFMLVIFLG 400
Query: 1181 VFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQ 1230
F +++++ V+ + + + I T ++ K+++ +++ ++ +
Sbjct: 401 SFYLVNLILAVVAMAYEEQ----NQATIAETEEKEKRFQEAMEMLKKEHE 446
Score = 53.5 bits (127), Expect = 2e-06
Identities = 52/234 (22%), Positives = 92/234 (39%), Gaps = 41/234 (17%)
Query: 454 EDATLRHKEELEKSKKICPLY-----------------WYKFAKTFLIWNCSPCWLKLKE 496
E+ R + +L+ SKK+ LY +Y KTF++ N +
Sbjct: 48 EEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSA 107
Query: 497 FVHRIIMAPFTDL--------------FLIICIILNVCFLTLEHYPMSKQTNTLLNIGNL 542
+++PF + LI+C IL C +H P
Sbjct: 108 TNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP-----PPWTKYVEY 162
Query: 543 VFIGIFTAEMIFKIIA----MHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLF 598
F I+T E + KI+A +H + + + WN D ++ + + + ++ LR F
Sbjct: 163 TFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENI-KLGNLSALRTF 221
Query: 599 RMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
R+LR K P + ++ +L S L D+++L + A G++LF N
Sbjct: 222 RVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGN 275
Score = 45.4 bits (106), Expect = 5e-04
Identities = 34/156 (21%), Positives = 74/156 (47%), Gaps = 11/156 (7%)
Query: 114 VLVHPFFQLFILISVLIDCVFMSL------TNLPKWRPVLENTLLGIYTFEILVKLFARG 167
V++ PF L I + ++++ +FM+L + + V GI+T E+ K+ A
Sbjct: 713 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA-- 770
Query: 168 VWAGSFSFLGDPWNWLDFSVTVFEVI-IRYSPLDFIPTLQTARTLRILKIIPLNQGLKSL 226
+ + WN D + + ++ + S + + L++ R LR+ K+ L +L
Sbjct: 771 --LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTL 828
Query: 227 VGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGN 262
+ ++ + + L + ++ + IF+++GM LF N
Sbjct: 829 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864
>gi|237512980 voltage-gated sodium channel type V alpha isoform e
[Homo sapiens]
Length = 1983
Score = 1067 bits (2759), Expect = 0.0
Identities = 584/1258 (46%), Positives = 800/1258 (63%), Gaps = 109/1258 (8%)
Query: 462 EELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCF 521
EELE+S+ CP W + A+ +LIW C P W+ +K+ V ++M PFTDL + +CI+LN F
Sbjct: 674 EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLF 733
Query: 522 LTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGL 581
+ LEHY M+ + +L +GNLVF GIFTAEM FKIIA+ PY YFQ GWNIFDS+IV L
Sbjct: 734 MALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSL 793
Query: 582 IELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFS 641
+EL L+ ++ +++LR FR+LR+FKL K WPT L+ + NS AL +L L+L +F
Sbjct: 794 MELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIF 853
Query: 642 AAFGMKLFGKNYEEFVCHIDKDC-QLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVA 700
A GM+LFGKNY E D D LPRWHM DFFH+FL +FRILCGEW+ET+WDCMEV+
Sbjct: 854 AVVGMQLFGKNYSEL---RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVS 910
Query: 701 GQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTA-EENNEAKNLQLAVARIKKGI 759
GQS C+ +L+V++IGNL+VL LFLAL+ S S ++TA +E+ E NLQLA+ARI++G+
Sbjct: 911 GQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGL 970
Query: 760 NYV---LLKILC--------------------------------KTQNVP---KDTMDHV 781
+V C +T+ VP K+T
Sbjct: 971 RFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEE 1030
Query: 782 NEVYVKEDISDH-----TLSELSNTQDFLKDKEKSS-GTEKNATENESQSLIPSPSVSET 835
E + D ++ + D ++ E++S GTE+ +++ ESQ + P E
Sbjct: 1031 GEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQESQPVSGGP---EA 1087
Query: 836 VPIASGESDIENLDNKEIQSKSGDGGSKEKIK------------QSSSSECSTVDIAISE 883
P + S + + E ++ + +++ K + S SE ST D+ +
Sbjct: 1088 PPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTA 1147
Query: 884 E--EEMFYGGERSKH----LKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFK 937
E E++ G+ K GC R + GK+W +RKTC IVE++WF+
Sbjct: 1148 ELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFE 1207
Query: 938 CFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFS 997
FI + LLS+G LAFEDIY+++RKTIK+LLEYAD +FTY+F+LEMLLKW+AYGFK YF+
Sbjct: 1208 TFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFT 1267
Query: 998 NGWYRLDFVVVIVFCLSLIGKT-----REELKPLISMKFLRPLRVLSQFERMKVVVRALI 1052
N W LDF++V V +SL+ T +K L +++ LRPLR LS+FE M+VVV AL+
Sbjct: 1268 NAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALV 1327
Query: 1053 KTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGE-RFPSSEVMNKSRCESLL 1111
+NV LVCL+ WLIFSIMGV+LFAG+F CI+ T G+ + V NKS+CESL
Sbjct: 1328 GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLN 1387
Query: 1112 FNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYC 1171
+ W K+NFDNVG G+L+LLQVATF GW+ IM +A+DS QP +E N+YMY
Sbjct: 1388 LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYI 1447
Query: 1172 YFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQR 1231
YF+ FIIFG F L++ I VIIDNFN+ K KLGG +IF+T +Q+K Y +KKL + Q+
Sbjct: 1448 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1507
Query: 1232 PVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFV 1291
P+PRPLNK QGFIFD+VT QAF+V +M LIC + MM++TD QS + L IN +FV
Sbjct: 1508 PIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFV 1567
Query: 1292 MLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLS 1351
++ TG L + Y P+L ++I L+
Sbjct: 1568 AIF--------------------------------TGTVLSDIIQKYFFSPTLFRVIRLA 1595
Query: 1352 RIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGI 1411
RI +LRL +G K L+ LM+SLPAL NI LL+FLVMFIY++FGM NFAYVK EAGI
Sbjct: 1596 RIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGI 1655
Query: 1412 NDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSV 1471
+D+ NF+TF NSMLCLFQ+ AGWDG+L I N+ CDP N RGDCG+P+V
Sbjct: 1656 DDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAV 1714
Query: 1472 GIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQ 1531
GI +F +YI+IS+LI+VNMYI +++E ++A+++ + LSEDDF F+++W++FDP+ TQ
Sbjct: 1715 GILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQ 1774
Query: 1532 YIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVR 1591
+I+ S LSDFA AL PL +AKPN+ LI +DLPM GDRIHC+DIL AFTKRV+G+
Sbjct: 1775 FIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGE 1834
Query: 1592 MEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTS 1649
M+ + ++E F+ ANP KI+ EPITTTL+RK E VSA +IQRA++ + L+R+ K+ S
Sbjct: 1835 MDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHAS 1892
Score = 381 bits (979), Expect = e-105
Identities = 209/463 (45%), Positives = 286/463 (61%), Gaps = 36/463 (7%)
Query: 13 FTKESFELIKQHIAK-------THNEDHE----EEDLKPTPDLEVGKKLPFIYGNLSQGM 61
FT+ES I++ +A+ T E E EE +P DL+ KKLP +YGN Q +
Sbjct: 16 FTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQEL 75
Query: 62 VSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQ 121
+ EPLED+DP+Y +K TFIVLNK +TIFRF+A + L LSPF+ IRR +K+LVH F
Sbjct: 76 IGEPLEDLDPFYSTQK-TFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFN 134
Query: 122 LFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWN 181
+ I+ ++L +CVFM+ + P W +E T IYTFE LVK+ ARG +F+FL DPWN
Sbjct: 135 MLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWN 194
Query: 182 WLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVI 241
WLDFSV + + L + L+T R LR LK I + GLK++VG LI +K+L V+
Sbjct: 195 WLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVM 254
Query: 242 ILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGN------------PYYI 289
+LT+F LS+F+LIG+ LFMGNL+HKC R N T N T Y+
Sbjct: 255 VLTVFCLSVFALIGLQLFMGNLRHKCVR------NFTALNGTNGSVEADGLVWESLDLYL 308
Query: 290 RETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRL 349
+ EN+ G LLCGN +DAG CPEGY C+KAG NPD G+T+FDSF WA ALFRL
Sbjct: 309 SDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRL 368
Query: 350 MAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISK 409
M QD E LY Q L ++GK+YMIFF++V FL SFY+ +L L ++AMAYEE+ Q ++
Sbjct: 369 MTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
Query: 410 KIEPKFQQTGKELQEGNE------TDEAKTIQIEMKKRSPIST 446
+ E +FQ+ + L++ +E D +EM +P+++
Sbjct: 429 EKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNS 471
Score = 104 bits (259), Expect = 8e-22
Identities = 145/681 (21%), Positives = 277/681 (40%), Gaps = 165/681 (24%)
Query: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNL----PKWRPVLENTLLGIYTFEILVK 162
+R+T ++ H +F+ FI+ +L+ ++ ++ K VL ++T+ +++
Sbjct: 1193 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1252
Query: 163 LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216
+ + V G + + W WLDF + ++ + ++ + I +L+T R LR L+
Sbjct: 1253 MLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRA 1312
Query: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQ---- 272
+ +G++ +V L+ + ++ V+++ L F IFS++G+ LF G +C +
Sbjct: 1313 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GRCINQTEGDLP 1371
Query: 273 --------ENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVK 324
+++ E+L N TG Y+ + NF + G Y L T G Y V
Sbjct: 1372 LNYTIVNNKSQCESL-NLTGELYWTKVKVNFDNV-GAGYLALLQVATFKGWMDIMYAAV- 1428
Query: 325 AGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFY 384
DS G+ ++ P+ Y+ +Y I+FV+ SF+
Sbjct: 1429 ------------DSRGY----------EEQPQWEYNLYMY-------IYFVIFIIFGSFF 1459
Query: 385 MASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPI 444
+LF+G++ + ++K+++G Q+ T+E K MKK
Sbjct: 1460 TLNLFIGVIIDNFNQQKKKLGG----------------QDIFMTEEQKKYYNAMKKLGS- 1502
Query: 445 STDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMA 504
+K +K P K+ + F+ I+
Sbjct: 1503 --------------------KKPQKPIPRPLNKY----------------QGFIFDIVTK 1526
Query: 505 PFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGY 564
D+ ++ I LN+ + +E S + +L NL+F+ IFT ++ II +
Sbjct: 1527 QAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGTVLSDIIQKY---- 1582
Query: 565 FQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSW 624
F S +F ++RL R+ RI +L + + L+++L S
Sbjct: 1583 -------FFSPTLFR--------------VIRLARIGRILRLIRGAKGIRTLLFALMMSL 1621
Query: 625 VALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRI 684
AL ++ LLLF +F + FGM F Y ++ ID ++ F +S L +F+I
Sbjct: 1622 PALFNIGLLLFLVMFIYSIFGMANFA--YVKWEAGID-----DMFNFQTFANSMLCLFQI 1674
Query: 685 LCGEWVETLWDCMEVAGQSWCIP--------------------FYLMVILIGNLLVLYLF 724
+ L + G +C P F+ I+I L+V+ ++
Sbjct: 1675 TTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMY 1734
Query: 725 LALV-SSFSSCKDVTAEENNE 744
+A++ +FS V EE+ E
Sbjct: 1735 IAIILENFS----VATEESTE 1751
Score = 67.8 bits (164), Expect = 9e-11
Identities = 59/240 (24%), Positives = 107/240 (44%), Gaps = 11/240 (4%)
Query: 854 QSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGA 913
Q+ DG + +Q + S S + A+ E EE S+H C + L Q
Sbjct: 646 QAPCVDGFEEPGARQRALSAVSVLTSALEELEE-------SRHKCPPC--WNRLAQRYLI 696
Query: 914 SKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADM 973
+ +W +I++ +V + + I + +L+T +A E M + +L+ ++
Sbjct: 697 WECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSE--FEEMLQVGNL 754
Query: 974 IFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLR 1033
+FT IF EM K +A YF GW D ++VI+ + L L L S + LR
Sbjct: 755 VFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLR 814
Query: 1034 PLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSG 1093
++ + + +++ + + N+ LV +I IF+++G+ LF + E D SG
Sbjct: 815 VFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSG 874
Score = 54.7 bits (130), Expect = 7e-07
Identities = 73/350 (20%), Positives = 147/350 (42%), Gaps = 65/350 (18%)
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
IR+ KI+ ++ F I + T+L+ ++M Q +Y + FT I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLI-MCTILTNC------VFMAQHDPPP-WTKYVEYTFTAIYTFE 171
Query: 983 MLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038
L+K +A GF + + W LDF V+I+ +S K L L + + LR L+ +
Sbjct: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGN-LSALRTFRVLRALKTI 230
Query: 1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG-------RFYECIDPT 1091
S +K +V ALI++ +V ++ + +F+++G+ LF G R + ++ T
Sbjct: 231 SVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGT 290
Query: 1092 SGE---------------RFPSSEVMNKSRCESLLFNES-------------MLWEN--- 1120
+G P + ++ + LL S EN
Sbjct: 291 NGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDH 350
Query: 1121 AKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFG 1180
+FD+ FL+L ++ T + W + + S IYM +F+ I G
Sbjct: 351 GYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFMLVIFLG 400
Query: 1181 VFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQ 1230
F +++++ V+ + + + I T ++ K+++ +++ ++ +
Sbjct: 401 SFYLVNLILAVVAMAYEEQ----NQATIAETEEKEKRFQEAMEMLKKEHE 446
Score = 53.5 bits (127), Expect = 2e-06
Identities = 52/234 (22%), Positives = 92/234 (39%), Gaps = 41/234 (17%)
Query: 454 EDATLRHKEELEKSKKICPLY-----------------WYKFAKTFLIWNCSPCWLKLKE 496
E+ R + +L+ SKK+ LY +Y KTF++ N +
Sbjct: 48 EEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSA 107
Query: 497 FVHRIIMAPFTDL--------------FLIICIILNVCFLTLEHYPMSKQTNTLLNIGNL 542
+++PF + LI+C IL C +H P
Sbjct: 108 TNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP-----PPWTKYVEY 162
Query: 543 VFIGIFTAEMIFKIIA----MHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLF 598
F I+T E + KI+A +H + + + WN D ++ + + + ++ LR F
Sbjct: 163 TFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENI-KLGNLSALRTF 221
Query: 599 RMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
R+LR K P + ++ +L S L D+++L + A G++LF N
Sbjct: 222 RVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGN 275
Score = 45.4 bits (106), Expect = 5e-04
Identities = 34/156 (21%), Positives = 74/156 (47%), Gaps = 11/156 (7%)
Query: 114 VLVHPFFQLFILISVLIDCVFMSL------TNLPKWRPVLENTLLGIYTFEILVKLFARG 167
V++ PF L I + ++++ +FM+L + + V GI+T E+ K+ A
Sbjct: 713 VVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIA-- 770
Query: 168 VWAGSFSFLGDPWNWLDFSVTVFEVI-IRYSPLDFIPTLQTARTLRILKIIPLNQGLKSL 226
+ + WN D + + ++ + S + + L++ R LR+ K+ L +L
Sbjct: 771 --LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTL 828
Query: 227 VGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGN 262
+ ++ + + L + ++ + IF+++GM LF N
Sbjct: 829 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864
>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
sapiens]
Length = 1956
Score = 1040 bits (2689), Expect = 0.0
Identities = 566/1255 (45%), Positives = 793/1255 (63%), Gaps = 78/1255 (6%)
Query: 462 EELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCF 521
EELE+S++ CP ++ +LIW+C P W+KLK + ++ PF +L + +CI++N F
Sbjct: 622 EELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIF 681
Query: 522 LTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGL 581
+ +EH+ MS +L IGN+VF FTAEM+FKIIA PY YFQ WNIFD +IV L
Sbjct: 682 MAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSL 741
Query: 582 IELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFS 641
+EL +A +++LR FR+LR+FKL K WPT L+ + NS AL +L ++L +F
Sbjct: 742 LELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVF 801
Query: 642 AAFGMKLFGKNYEEFVCHIDKDCQ-LPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVA 700
A G +L G+NY +I + PRWHMHDFFHSFL VFRILCGEW+E +W CMEV
Sbjct: 802 ALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVG 861
Query: 701 GQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTA-EENNEAKNLQLAVARIKKGI 759
+S C+ +L V+++GNL+VL LF+AL+ + S ++TA E++ E NLQ+A+ARI+
Sbjct: 862 QKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQV-F 920
Query: 760 NYVLLKILCK--TQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEK- 816
+ + LC +++ P E+ VK +S S+ N + S G +
Sbjct: 921 GHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLSS---SKAENHIAANTARGSSGGLQAP 977
Query: 817 NATENESQSLIPSPSVSETVPIASGESDIENL------DNKEIQSKSGDGGSKEKIKQ-- 868
+E I +P+V +VPIA GESD+++L D + Q + G +E+++Q
Sbjct: 978 RGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVE 1037
Query: 869 -------------------------------------------SSSSECSTVDIAISEEE 885
+SSSE STVD + EE
Sbjct: 1038 RCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVD-CLDPEE 1096
Query: 886 EMFYGGERSKHLKN-------GCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKC 938
+ E + L+ GC R ++ + +RKTC +IVE++WF+
Sbjct: 1097 ILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFES 1156
Query: 939 FIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSN 998
FI + LLS+G+LAFED Y+DQ+ T+K LLEY D +FT+IF+ EMLLKW+AYGFK YF+N
Sbjct: 1157 FIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTN 1216
Query: 999 GWYRLDFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERMKVVVRALIK 1053
W LDF++V + +SL K E +K L +++ LRPLR LS+FE M+VVV AL+
Sbjct: 1217 AWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVG 1276
Query: 1054 TTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGE--RFPSSEVMNKSRCESLL 1111
+NV LVCL+ WLIFSIMGV+LFAG+F+ CI+ T GE P S V NKS C+
Sbjct: 1277 AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQN 1336
Query: 1112 FNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYC 1171
S W N K+NFDNV G+L+LLQVATF GW+ IM +A+DS VN+QP +E N+YMY
Sbjct: 1337 STGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYL 1396
Query: 1172 YFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQR 1231
YF+ FIIFG F L++ + VIIDNFN+ K KLGG +IF+T +Q+K Y +KKL + Q+
Sbjct: 1397 YFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1456
Query: 1232 PVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFV 1291
P+PRPLNK QGF+FD+VT QAF++ +MVLIC I MM++TD QS + + L IN FV
Sbjct: 1457 PIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFV 1516
Query: 1292 MLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSY--LVPPSLVQLIL 1349
++T EC++K+ A R +YFT WN+FDF+VV+ SI L + S P+L ++I
Sbjct: 1517 AVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIR 1576
Query: 1350 LSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEA 1409
L+RI +LRL + K L+ LM+SLPAL NI LL+FLVMFIY++FGM +F +V+ EA
Sbjct: 1577 LARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEA 1636
Query: 1410 GINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNP 1469
GI+D+ NF+TF NSMLCLFQ+ AGWDG+L I N+ CDP+ N RGDCG+P
Sbjct: 1637 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPN-SNGTRGDCGSP 1695
Query: 1470 SVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDR 1529
+VGI +F +YI+IS+LI+VNMYI V++E N+A+++ + LSEDDF F++ W++FDP+
Sbjct: 1696 AVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEA 1755
Query: 1530 TQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQD 1589
TQ+I S LSDFA L PL + KPN+ LI +DLP+ GD+IHCLDIL AFTK V+G+
Sbjct: 1756 TQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGES 1815
Query: 1590 VRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRN 1644
++ + + +E F+ N K + EPI TTL+ KQE +SAT+IQ+AY++Y L R+
Sbjct: 1816 GELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRS 1870
Score = 351 bits (900), Expect = 4e-96
Identities = 201/459 (43%), Positives = 274/459 (59%), Gaps = 25/459 (5%)
Query: 2 LASPEPKGLVPFTKESFELIKQHIA---------KTHNEDHEEEDLKPTP--DLEVGKKL 50
+ S E FT ES I++ IA + H E ++E+ KP P DL+ +L
Sbjct: 5 IGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEE-KPRPQLDLKACNQL 63
Query: 51 PFIYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRT 110
P YG L ++ EPLED+DP+Y + TF+VLNK RTI RF+A L SPFN IRRT
Sbjct: 64 PKFYGELPAELIGEPLEDLDPFYSTHR-TFMVLNKGRTISRFSATRALWLFSPFNLIRRT 122
Query: 111 TIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWA 170
IKV VH +F LFI +++L++CV M+ T+LP+ +E IYTFE L+K+ ARG
Sbjct: 123 AIKVSVHSWFSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCL 179
Query: 171 GSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVL 230
F++L DPWNWLDFSV + L I L+T R LR LK + + GLK +VG L
Sbjct: 180 NEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGAL 239
Query: 231 IHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIR 290
IH +K+L V ILT+F LS+F+L+G+ LF GNLK+KC + N+ N T N R
Sbjct: 240 IHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVK------NDMAVNETTNYSSHR 293
Query: 291 ETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLM 350
+ + + G LLCGN +D+G CP+GY+C+K NPD +T+FDSF WA +LFRLM
Sbjct: 294 KPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLM 353
Query: 351 AQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKK 410
QD E LY Q L SGK+YMIFFV+V FL SFY+ +L L ++ MAYEE+ Q + +
Sbjct: 354 TQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEA 413
Query: 411 IEPKFQQTGKELQEGNETDEA---KTIQIEMKKRSPIST 446
E KFQ+ + L++ E A T + SP+++
Sbjct: 414 KEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTS 452
Score = 125 bits (315), Expect = 3e-28
Identities = 148/703 (21%), Positives = 290/703 (41%), Gaps = 157/703 (22%)
Query: 100 TLSPFNC---IRRTTIKVLVHPFFQLFILISVLIDCVFMS-----LTNLPKWRPVLENTL 151
T SP++ +R+T +++ H +F+ FI+ +L+ ++ L P + +LE T
Sbjct: 1131 TKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTD 1190
Query: 152 LGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTL 205
++TF + ++ + V G + + W WLDF + +I + YS + I L
Sbjct: 1191 R-VFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKAL 1249
Query: 206 QTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKH 265
+T R LR L+ + +G++ +V L+ + ++ V+++ L F IFS++G+ LF G
Sbjct: 1250 RTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-W 1308
Query: 266 KCFRWPQENEN---ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVC 322
+C + + ++ N + T +F+++ +
Sbjct: 1309 RCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVK--------------------- 1347
Query: 323 VKAGINPDQGFTNFDSFGWALFALFRLMA-QDYPEVLYHQILYA--------SGKVYMIF 373
NFD+ AL ++ + + +++Y + VYM
Sbjct: 1348 -----------VNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYL 1396
Query: 374 FVVVSFLF-SFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAK 432
+ V+ +F F+ +LF+G++ + ++K+++G Q+ T+E K
Sbjct: 1397 YFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGG----------------QDIFMTEEQK 1440
Query: 433 TIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWL 492
MKK +K +K P KF
Sbjct: 1441 KYYNAMKKLGS---------------------KKPQKPIPRPLNKF-------------- 1465
Query: 493 KLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEM 552
+ FV I+ D+ +++ I LN+ + +E S++ +L N F+ +FT E
Sbjct: 1466 --QGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGEC 1523
Query: 553 IFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAG----------MALLRLFRMLR 602
+ K+ A+ Y YF GWN+FD ++V + L + + ++RL R+ R
Sbjct: 1524 VMKMFALRQY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGR 1582
Query: 603 IFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDK 662
I +L + + L+++L S AL ++ LLLF +F + FGM F + + ID
Sbjct: 1583 ILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSF--PHVRWEAGID- 1639
Query: 663 DCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIP--------------- 707
++ F +S L +F+I + L + G +C P
Sbjct: 1640 ----DMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSP 1695
Query: 708 -----FYLMVILIGNLLVLYLFLALV-SSFSSCKDVTAEENNE 744
F+ I+I L+++ +++A++ +F +V EE+ E
Sbjct: 1696 AVGIIFFTTYIIISFLIMVNMYIAVILENF----NVATEESTE 1734
Score = 68.2 bits (165), Expect = 7e-11
Identities = 70/302 (23%), Positives = 126/302 (41%), Gaps = 56/302 (18%)
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
IR+T K+ ++WF FI + L++ + D L E + +FT I+ E
Sbjct: 119 IRRTAIKVSVHSWFSLFITVTILVNCVCMTRTD-----------LPEKIEYVFTVIYTFE 167
Query: 983 MLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTRE--ELKPLISMKFLRPLR 1036
L+K +A GF Y + W LDF V+ L+ +G + + L + + LR L+
Sbjct: 168 ALIKILARGFCLNEFTYLRDPWNWLDFSVIT---LAYVGTAIDLRGISGLRTFRVLRALK 224
Query: 1037 VLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRF-YECIDPT---- 1091
+S +KV+V ALI + +V ++ + +F+++G+ LF G +C+
Sbjct: 225 TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVN 284
Query: 1092 -----SGERFPSSEVMNKSRCESLLFNES-------------MLWENAKMN---FDNVGN 1130
S R P + + + LL +N N FD+
Sbjct: 285 ETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAW 344
Query: 1131 GFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLIT 1190
FLSL ++ T + W + + + IYM +F+ I G F +++++
Sbjct: 345 AFLSLFRLMTQDSWERLYQQTLRTSG---------KIYM-IFFVLVIFLGSFYLVNLILA 394
Query: 1191 VI 1192
V+
Sbjct: 395 VV 396
Score = 40.8 bits (94), Expect = 0.011
Identities = 44/199 (22%), Positives = 80/199 (40%), Gaps = 37/199 (18%)
Query: 1236 PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYT 1295
P N ++ V F++ + V I + M TD+ I +F ++YT
Sbjct: 115 PFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMT-RTDLPEK--------IEYVFTVIYT 165
Query: 1296 MECILKLIAFRCF------YFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLIL 1349
E ++K++A R F Y WN DF V+ + G + + S L
Sbjct: 166 FEALIKILA-RGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGL---------- 214
Query: 1350 LSRIIHMLRLGKGPKVFHNLML---PLMLSLPALLNIILLIFLVMFIYAVFGMYNF---- 1402
R +LR K V L + L+ S+ L ++ +L + ++A+ G+ F
Sbjct: 215 --RTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNL 272
Query: 1403 --AYVKKEAGINDVSNFET 1419
VK + +N+ +N+ +
Sbjct: 273 KNKCVKNDMAVNETTNYSS 291
Score = 39.7 bits (91), Expect = 0.025
Identities = 37/182 (20%), Positives = 86/182 (47%), Gaps = 18/182 (9%)
Query: 114 VLVHPFFQLFILISVLIDCVFMSLTN---LPKWRPVLE--NTLLGI-YTFEILVKLFARG 167
++ PF +L I + ++++ +FM++ + P + +L+ N + I +T E++ K+ A
Sbjct: 661 LVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA-- 718
Query: 168 VWAGSFSFLGDPWNWLD-FSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSL 226
+ + WN D VTV + + + + L++ R LR+ K+ L +L
Sbjct: 719 --FDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTL 776
Query: 227 VGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFR-------WPQENENETL 279
+ ++ + + L + I+ + +F+L+G L N ++ WP+ + ++
Sbjct: 777 IKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFF 836
Query: 280 HN 281
H+
Sbjct: 837 HS 838
>gi|239748090 PREDICTED: similar to sodium channel, voltage-gated,
type V, alpha (long QT syndrome 3) [Homo sapiens]
Length = 1637
Score = 661 bits (1706), Expect = 0.0
Identities = 375/837 (44%), Positives = 512/837 (61%), Gaps = 66/837 (7%)
Query: 720 VLYLFLALVSSFSSCKDVTA-EENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTM 778
VL LFLAL+ S S ++TA +E+ E NLQLA+ARI++G+ +V
Sbjct: 631 VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFV---------------- 674
Query: 779 DHVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQSLI-----PSPSVS 833
K D L +++ A + + S I P P +
Sbjct: 675 --------KRTTWDFCCGLL---------RQRPQKPAALAAQGQLPSCIATPYSPPPPET 717
Query: 834 ETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGER 893
E VP E+ E + Q G G E + C + +A S+ ++ E
Sbjct: 718 EKVPPTRKETRFEEGE----QPGQGTPGDPEPV-------CVPIAVAESDTDDQEEDEEN 766
Query: 894 SKHLKNGCRRGSSLGQISG---ASKKGKIWQNIRKTCCKIVENN-----WFKCFIGLVTL 945
S + + +SG A + W + T E + W + +
Sbjct: 767 SLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQA 826
Query: 946 LSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDF 1005
G AFEDIY+++RKTIK+LLEYAD +FTY+F+LEMLLKW+AYGFK YF+N W LDF
Sbjct: 827 PGCGE-AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDF 885
Query: 1006 VVVIVFCLSLIGKT-----REELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLN 1060
++V V +SL+ T +K L +++ LRPLR LS+FE M+VVV AL+ +N
Sbjct: 886 LIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMN 945
Query: 1061 VFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGER-FPSSEVMNKSRCESLLFNESMLWE 1119
V LVCL+ WLIFSIMGV+LFAG+F CI+ T G+ + V NKS+CESL + W
Sbjct: 946 VLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWT 1005
Query: 1120 NAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIF 1179
K+NFDNVG G+L+LLQVATF GW+ IM +A+DS QP +E N+YMY YF+ FIIF
Sbjct: 1006 KVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIF 1065
Query: 1180 GVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNK 1239
G F L++ I VIIDNFN+ K KLGG +IF+T +Q+K Y +KKL + Q+P+PRPLNK
Sbjct: 1066 GSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1125
Query: 1240 LQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECI 1299
QGFIFD+VT QAF+V +M LIC + MM++TD QS + L IN +FV ++T ECI
Sbjct: 1126 YQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECI 1185
Query: 1300 LKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRL 1359
+KL A R +YFT +WNIFDF+VVI SI G L + Y P+L ++I L+RI +LRL
Sbjct: 1186 VKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRL 1245
Query: 1360 GKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFET 1419
+G K L+ LM+SLPAL NI LL+FLVMFIY++FGM NFAYVK EAGI+D+ NF+T
Sbjct: 1246 IRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQT 1305
Query: 1420 FGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSY 1479
F NSMLCLFQ+ AGWDG+L I N+ CDP N RGDCG+P+VGI +F +Y
Sbjct: 1306 FANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTY 1364
Query: 1480 ILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSS 1536
I+IS+LI+VNMYI +++E ++A+++ + LSEDDF F+++W++FDP+ TQ+I+ S
Sbjct: 1365 IIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYS 1421
Score = 383 bits (983), Expect = e-106
Identities = 209/463 (45%), Positives = 286/463 (61%), Gaps = 36/463 (7%)
Query: 13 FTKESFELIKQHIAK-------THNEDHE----EEDLKPTPDLEVGKKLPFIYGNLSQGM 61
FT+ES I++ +A+ T E E EE +P DL+ KKLP +YGN Q +
Sbjct: 16 FTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQEL 75
Query: 62 VSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQ 121
+ EPLED+DP+Y +K TFIVLNK +TIFRF+A + L LSPF+ IRR +K+LVH F
Sbjct: 76 IGEPLEDLDPFYSTQK-TFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFN 134
Query: 122 LFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWN 181
+ I+ ++L +CVFM+ + P W +E T IYTFE LVK+ ARG +F+FL DPWN
Sbjct: 135 MLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWN 194
Query: 182 WLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVI 241
WLDFSV + + L + L+T R LR LK I + GLK++VG LI +K+L V+
Sbjct: 195 WLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVM 254
Query: 242 ILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGN------------PYYI 289
+LT+F LS+F+LIG+ LFMGNL+HKC R N T N T Y+
Sbjct: 255 VLTVFCLSVFALIGLQLFMGNLRHKCVR------NFTALNGTNGSVEADGLVWESLDLYL 308
Query: 290 RETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRL 349
+ EN+ G LLCGN +DAG CPEGY C+KAG NPD G+T+FDSF WA ALFRL
Sbjct: 309 SDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRL 368
Query: 350 MAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISK 409
M QD E LY Q L ++GK+YMIFF++V FL SFY+ +L L ++AMAYEE+ Q ++
Sbjct: 369 MTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428
Query: 410 KIEPKFQQTGKELQEGNE------TDEAKTIQIEMKKRSPIST 446
+ E +FQ+ + L++ +E D +EM +P+++
Sbjct: 429 EKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNS 471
Score = 122 bits (307), Expect = 2e-27
Identities = 144/638 (22%), Positives = 268/638 (42%), Gaps = 145/638 (22%)
Query: 154 IYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQT 207
++T+ ++++ + V G + + W WLDF + ++ + ++ + I +L+T
Sbjct: 854 MFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRT 913
Query: 208 ARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKC 267
R LR L+ + +G++ +V L+ + ++ V+++ L F IFS++G+ LF G +C
Sbjct: 914 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG-RC 972
Query: 268 FRWPQ------------ENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQ 315
+ +++ E+L N TG Y+ + NF + G Y L T G
Sbjct: 973 INQTEGDLPLNYTIVNNKSQCESL-NLTGELYWTKVKVNFDNV-GAGYLALLQVATFKGW 1030
Query: 316 CPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFV 375
Y V DS G+ ++ P+ Y+ +Y I+FV
Sbjct: 1031 MDIMYAAV-------------DSRGY----------EEQPQWEYNLYMY-------IYFV 1060
Query: 376 VVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQ 435
+ SF+ +LF+G++ + ++K+++G Q+ T+E K
Sbjct: 1061 IFIIFGSFFTLNLFIGVIIDNFNQQKKKLGG----------------QDIFMTEEQKKYY 1104
Query: 436 IEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLK 495
MKK +K +K P K+ +
Sbjct: 1105 NAMKKLGS---------------------KKPQKPIPRPLNKY----------------Q 1127
Query: 496 EFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFK 555
F+ I+ D+ ++ I LN+ + +E S + +L NL+F+ IFT E I K
Sbjct: 1128 GFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVK 1187
Query: 556 IIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLG 607
+ A+ Y YF WNIFD ++V ++ L+++ ++RL R+ RI +L
Sbjct: 1188 LAALRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLI 1246
Query: 608 KYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLP 667
+ + L+++L S AL ++ LLLF +F + FGM F Y ++ ID
Sbjct: 1247 RGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA--YVKWEAGID-----D 1299
Query: 668 RWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIP-------------------- 707
++ F +S L +F+I + L + G +C P
Sbjct: 1300 MFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGIL 1359
Query: 708 FYLMVILIGNLLVLYLFLALV-SSFSSCKDVTAEENNE 744
F+ I+I L+V+ +++A++ +FS V EE+ E
Sbjct: 1360 FFTTYIIISFLIVVNMYIAIILENFS----VATEESTE 1393
Score = 51.6 bits (122), Expect = 6e-06
Identities = 69/351 (19%), Positives = 146/351 (41%), Gaps = 67/351 (19%)
Query: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
IR+ KI+ ++ F I + T+L+ ++M Q +Y + FT I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLI-MCTILTNC------VFMAQHDPPP-WTKYVEYTFTAIYTFE 171
Query: 983 MLLKWMAYGFK----AYFSNGWYRLDF-VVVIVFCLSLIGKTREELKPLISMKFLRPLRV 1037
L+K +A GF + + W LDF V+++ + + + L + + LR L+
Sbjct: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGN--VSALRTFRVLRALKT 229
Query: 1038 LSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG-------RFYECIDP 1090
+S +K +V ALI++ +V ++ + +F+++G+ LF G R + ++
Sbjct: 230 ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNG 289
Query: 1091 TSGE---------------RFPSSEVMNKSRCESLLFNES-------------MLWEN-- 1120
T+G P + ++ + LL S EN
Sbjct: 290 TNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD 349
Query: 1121 -AKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIF 1179
+FD+ FL+L ++ T + W + + S IYM +F+ I
Sbjct: 350 HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFMLVIFL 399
Query: 1180 GVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQ 1230
G F +++++ V+ + + + I T ++ K+++ +++ ++ +
Sbjct: 400 GSFYLVNLILAVVAMAYEEQ----NQATIAETEEKEKRFQEAMEMLKKEHE 446
Score = 49.7 bits (117), Expect = 2e-05
Identities = 54/235 (22%), Positives = 93/235 (39%), Gaps = 43/235 (18%)
Query: 454 EDATLRHKEELEKSKKICPLY-----------------WYKFAKTFLIWNCSPCWLKLKE 496
E+ R + +L+ SKK+ LY +Y KTF++ N +
Sbjct: 48 EEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSA 107
Query: 497 FVHRIIMAPFTDL--------------FLIICIILNVCFLTLEHYPMSKQTNTLLNIGNL 542
+++PF + LI+C IL C +H P
Sbjct: 108 TNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP-----PPWTKYVEY 162
Query: 543 VFIGIFTAEMIFKIIA----MHPYGYFQVGWNIFD-SMIVFHGLIELCLANVAGMALLRL 597
F I+T E + KI+A +H + + + WN D S+I+ E ++ ++ LR
Sbjct: 163 TFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTE--FVDLGNVSALRT 220
Query: 598 FRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
FR+LR K + ++ +L S L D+++L + A G++LF N
Sbjct: 221 FRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGN 275
Score = 41.6 bits (96), Expect = 0.007
Identities = 35/120 (29%), Positives = 59/120 (49%), Gaps = 20/120 (16%)
Query: 152 LGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVF--------EVIIRYSPLDFIP 203
+ I+T E +VKL A + + + WN DF V + ++I +Y F P
Sbjct: 1177 VAIFTGECIVKLAALRHY-----YFTNSWNIFDFVVVILSIVGTVLSDIIQKYF---FSP 1228
Query: 204 TL----QTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLF 259
TL + AR RIL++I +G+++L+ L+ L L + +L + I+S+ GM F
Sbjct: 1229 TLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1288
Score = 40.8 bits (94), Expect = 0.011
Identities = 34/142 (23%), Positives = 61/142 (42%), Gaps = 7/142 (4%)
Query: 531 KQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVA 590
K LL + +F +F EM+ K +A YF W D +IV L+ L +AN
Sbjct: 842 KTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSL-VANTL 900
Query: 591 GMA------LLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAF 644
G A LR R LR + + ++++ +L + ++ +++L+ F +
Sbjct: 901 GFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIM 960
Query: 645 GMKLFGKNYEEFVCHIDKDCQL 666
G+ LF + + + D L
Sbjct: 961 GVNLFAGKFGRCINQTEGDLPL 982
Score = 34.7 bits (78), Expect = 0.80
Identities = 33/172 (19%), Positives = 70/172 (40%), Gaps = 20/172 (11%)
Query: 1236 PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYT 1295
P + ++ ++ FN+++M I + M + ++ F +YT
Sbjct: 116 PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTK------YVEYTFTAIYT 169
Query: 1296 MECILKLIA--FRCFYFTIA---WNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILL 1350
E ++K++A F FT WN DF V+I + T + V V +
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYT---------TEFVDLGNVSALRT 220
Query: 1351 SRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF 1402
R++ L+ ++ L+ S+ L ++++L + ++A+ G+ F
Sbjct: 221 FRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272
>gi|193794832 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoforom 13 [Homo sapiens]
Length = 2144
Score = 408 bits (1049), Expect = e-113
Identities = 396/1566 (25%), Positives = 703/1566 (44%), Gaps = 226/1566 (14%)
Query: 96 SILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSL-------------TNLPK 142
++LC L+ N IRR I ++ F++ IL+++ +CV +++ +NL +
Sbjct: 103 ALLC-LTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLER 161
Query: 143 WRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTV---FEVIIRYSPL 199
+E L I+T E +K+ A G+ ++L + WN LDF + V F I+ +
Sbjct: 162 ----VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK 217
Query: 200 DF-------------IPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLF 246
+ L+ R LR L+++ L+ ++ +I + L+ + +L LF
Sbjct: 218 ADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 277
Query: 247 FLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALL 306
+ I+++IG+ LFMG + C+ QE + +P
Sbjct: 278 VIIIYAIIGLELFMGKMHKTCYN--QEGIADVPAEDDPSP-------------------- 315
Query: 307 CGNRTDAG-QCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQD-YPEVLYHQILY 364
C T G QC G VC P G TNFD+F +A+ +F+ + + + +VLY +
Sbjct: 316 CALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYW-VND 374
Query: 365 ASGKVY-MIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRV---GEISKKIEPKFQQTGK 420
A G+ + I+FV + + SF++ +L LG+L+ + +E+++ G+ K E QQ +
Sbjct: 375 AVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREK--QQLEE 432
Query: 421 ELQ------------------EGNETDEAKTIQIEMKKRSPISTDTSL--DVL-EDATLR 459
+L+ EG + ++ + + + + ++T+ D+ E+ R
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 460 HKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNV 519
+ KSK F++ + WN C K + V + +I + LN
Sbjct: 493 LAHRISKSK---------FSRYWRRWNRF-CRRKCRAAVKSNVFY----WLVIFLVFLNT 538
Query: 520 CFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFH 579
+ EHY + + N + +FTAEM+ K+ ++ YF +N FD +V
Sbjct: 539 LTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCG 598
Query: 580 GLIELCLANVA-----GMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLL 634
G++E L G+++LR R+LRIFK+ +YW + L+ SL NS ++ L+LLL
Sbjct: 599 GILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLL 658
Query: 635 FTFIFFSAAFGMKLFGK--NYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVE 691
F FI + GM+LFG N++E Q R +F S L VF+IL GE W
Sbjct: 659 FLFIIIFSLLGMQLFGGKFNFDEM--------QTRRSTFDNFPQSLLTVFQILTGEDWNS 710
Query: 692 TLWD-CMEVAGQSW-----CIPFYLMVILIGNLLVLYLFLAL-VSSFSSCKDVTAEENNE 744
++D M G S+ CI +++++ + GN ++L +FLA+ V + + + +T+ + E
Sbjct: 711 VMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769
Query: 745 AKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDF 804
+ + K L +T + K + V++ + E +
Sbjct: 770 EEEKER--------------KKLARTASPEK------KQELVEKPAVGESKEEKIELKSI 809
Query: 805 LKDKEKSSGTEKNATE---NESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGG 861
D E T+ N + NE++ P P+ P +GE D E + + G
Sbjct: 810 TADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEE-------EPEMPVGP 857
Query: 862 SKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQ 921
+ + E + + + E F ++
Sbjct: 858 RPRPLSELHLKEKA---VPMPEASAFFIFSSNNR-------------------------- 888
Query: 922 NIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFIL 981
R C +IV + F I LLS+ +LA ED IL Y D++FT IF +
Sbjct: 889 -FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILF-YFDIVFTTIFTI 946
Query: 982 EMLLKWMAYG---FKAYFSNGWYR-LDFVVVIVFCLS--LIGKTREELKPLISMKFLRPL 1035
E+ LK AYG K F ++ LD +VV V +S + +K L ++ LRPL
Sbjct: 947 EIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPL 1006
Query: 1036 RVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPT--SG 1093
R +++ + +K VV+ + N+ +V ++ +F+ +GV LF G+ Y C D + +
Sbjct: 1007 RAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTE 1066
Query: 1094 ERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAID 1153
+ + K + WEN+K +FDNV ++L V+TF GW ++ +ID
Sbjct: 1067 AECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSID 1126
Query: 1154 SVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVK 1213
S + P + + + +FI +II F +++ + +I F + G + +
Sbjct: 1127 SHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQ-----GEQEYKNCE 1181
Query: 1214 QRKQYRRLKKLMYEDSQRPVPR--PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMID 1271
K R+ + Y RP+ R P N+ Q ++ VV S F ++ VLI I + +
Sbjct: 1182 LDKNQRQC--VEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1272 TDVQSLQMSIALYWINSIFVMLYTMECILKLIAFR-CFYFTIAWNIFDFMVVIFSITGLC 1330
QS IA+ +N +F L+T+E ILKLIAF+ YF AWN FD ++V+ SI +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1331 LPMTV-GSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFL 1389
+ + + + +L + R++ +L G+G L+ + S AL + LLI +
Sbjct: 1300 ITENAEENSRISITFFRLFRVMRLVKLLSRGEG---IRTLLWTFIKSFQALPYVALLIVM 1356
Query: 1390 VMFIYAVFGMYNFAYV--KKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSK 1447
+ FIYAV GM F + IN +NF+TF ++L LF+ A W ++ A K
Sbjct: 1357 LFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGK 1416
Query: 1448 WSDCDPDKINPGTQVRGD--CGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKK 1505
C P+ P G+ CG+ S +FYF+S+ ++ +I+N+++ V+M+ + ++
Sbjct: 1417 --KCAPES-EPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRD 1472
Query: 1506 KNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAK--PNK---GQLI 1560
+ L +F ++W +DP+ I + + PPL K P++ +L+
Sbjct: 1473 WS-ILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV 1531
Query: 1561 ALDLPM 1566
++++P+
Sbjct: 1532 SMNMPL 1537
Score = 149 bits (375), Expect = 3e-35
Identities = 155/682 (22%), Positives = 283/682 (41%), Gaps = 144/682 (21%)
Query: 95 ASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLL-- 152
AS S N R +++ F IL +L+ + ++ + P N +L
Sbjct: 877 ASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED-PVQHTSFRNHILFY 935
Query: 153 ------GIYTFEILVKLFARGVWAGSFSFLGDPWNWLDF---SVTVFEVIIRYSPLDFIP 203
I+T EI +K+ A G + SF + +N LD SV++ I+ S ++ +
Sbjct: 936 FDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 204 TLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNL 263
L+ R LR L+ I +GLK +V + ++ + ++I+T +F+ IG+ LF G L
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 264 KHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCV 323
+ C ++ E E N YI Y +GE + R
Sbjct: 1056 -YTCSDSSKQTEAECKGN------YIT------YKDGEVDHPIIQPR------------- 1089
Query: 324 KAGINPDQGFTNFDSFGWALFALFRLMA-QDYPEVLYHQI---LYASGKVY------MIF 373
+ + +FD+ A+ ALF + + +PE+LY I G +Y IF
Sbjct: 1090 ----SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1145
Query: 374 FVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKT 433
F++ + +F+M ++F+G + + ++E+ ++ E K
Sbjct: 1146 FIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ--------------------------EYKN 1179
Query: 434 IQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWY--KFAKTFLIWNCSPCW 491
+++ +R + E + K PL Y K + +W
Sbjct: 1180 CELDKNQRQCV--------------------EYALKARPLRRYIPKNQHQYKVW------ 1213
Query: 492 LKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAE 551
++ + + + + + I+LN L ++HY S +NI N++F G+FT E
Sbjct: 1214 --------YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVE 1265
Query: 552 MIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVA------GMALLRLFRMLRIFK 605
MI K+IA P YF WN FD++IV ++++ + A + RLFR++R+ K
Sbjct: 1266 MILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITENAEENSRISITFFRLFRVMRLVK 1325
Query: 606 LGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQ 665
L + L+W+ S+ AL + LL+ F A GM++FGK I+++
Sbjct: 1326 LLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN- 1384
Query: 666 LPRWHMHDFFHSFLNVFRILCGE-WVETLWDCM------------------EVAGQSWCI 706
+ F + L +FR GE W + + CM G S+ +
Sbjct: 1385 ----NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAV 1440
Query: 707 PFYLMVILIGNLLVLYLFLALV 728
+++ ++ L++ LF+A++
Sbjct: 1441 FYFISFYMLCAFLIINLFVAVI 1462
Score = 71.2 bits (173), Expect = 8e-12
Identities = 86/392 (21%), Positives = 160/392 (40%), Gaps = 89/392 (22%)
Query: 1206 SNIFITVKQRKQYRRLKKLMYEDSQRPVPRPL------NKLQGFIFDVVTSQAFNVIVMV 1259
S + T ++R+QY + KK + RP PR L N ++ +V + F +I+++
Sbjct: 74 STVSSTQRKRQQYGKPKKQGSTTATRP-PRALLCLTLKNPIRRACISIVEWKPFEIIILL 132
Query: 1260 LICFQAIAMMIDT---DVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCF-----YFT 1311
I +A+ I + S + L + +F++++T+E LK+IA+ Y
Sbjct: 133 TIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLR 192
Query: 1312 IAWNIFDFMVVIFSITGLCLPMTV---GSYLVPPSL----VQLILLSRIIHMLRLGKGPK 1364
WN+ DF++V+ + L G+ + V+ + R++ LRL G
Sbjct: 193 NGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVP 252
Query: 1365 VFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF-----AYVKKEAGINDV----- 1414
++ ++ ++ LL+I LL+ V+ IYA+ G+ F + GI DV
Sbjct: 253 SLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDD 312
Query: 1415 -------------------------------SNFETFGNSMLCLFQVAIFAGWDGMLDAI 1443
+NF+ F +ML +FQ GW +L +
Sbjct: 313 PSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 1444 FNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVM-EFLNIA 1502
++ D YFV+ I+I ++N+ + V+ EF
Sbjct: 373 NDAVGRDWP--------------------WIYFVTLIIIGSFFVLNLVLGVLSGEF---- 408
Query: 1503 SKKKNKTLSEDDFRKFFQVWKRFDPDRTQYID 1534
SK++ K + DF+K + ++ + D Y+D
Sbjct: 409 SKEREKAKARGDFQKLREK-QQLEEDLKGYLD 439
>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 20 [Homo sapiens]
Length = 2127
Score = 407 bits (1046), Expect = e-113
Identities = 394/1565 (25%), Positives = 701/1565 (44%), Gaps = 222/1565 (14%)
Query: 96 SILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSL-------------TNLPK 142
++LC L+ N IRR I ++ F++ IL+++ +CV +++ +NL +
Sbjct: 103 ALLC-LTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLER 161
Query: 143 WRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTV---FEVIIRYSPL 199
+E L I+T E +K+ A G+ ++L + WN LDF + V F I+ +
Sbjct: 162 ----VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK 217
Query: 200 DF-------------IPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLF 246
+ L+ R LR L+++ L+ ++ +I + L+ + +L LF
Sbjct: 218 ADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 277
Query: 247 FLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALL 306
+ I+++IG+ LFMG + C+ QE + +P
Sbjct: 278 VIIIYAIIGLELFMGKMHKTCYN--QEGIADVPAEDDPSP-------------------- 315
Query: 307 CGNRTDAG-QCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQD-YPEVLYHQILY 364
C T G QC G VC P G TNFD+F +A+ +F+ + + + +VLY +
Sbjct: 316 CALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYW-VND 374
Query: 365 ASGKVY-MIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRV---GEISKKIEPKFQQTGK 420
A G+ + I+FV + + SF++ +L LG+L+ + +E+++ G+ K E QQ +
Sbjct: 375 AVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREK--QQLEE 432
Query: 421 ELQ------------------EGNETDEAKTIQIEMKKRSPISTDTSL--DVL-EDATLR 459
+L+ EG + ++ + + + + ++T+ D+ E+ R
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 460 HKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNV 519
+ KSK F++ + WN C K + V + +I + LN
Sbjct: 493 LAHRISKSK---------FSRYWRRWNRF-CRRKCRAAVKSNVFY----WLVIFLVFLNT 538
Query: 520 CFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFH 579
+ EHY + + N + +FTAEM+ K+ ++ YF +N FD +V
Sbjct: 539 LTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCG 598
Query: 580 GLIELCLANVA-----GMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLL 634
G++E L G+++LR R+LRIFK+ +YW + L+ SL NS ++ L+LLL
Sbjct: 599 GILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLL 658
Query: 635 FTFIFFSAAFGMKLFGK--NYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVE 691
F FI + GM+LFG N++E Q R +F S L VF+IL GE W
Sbjct: 659 FLFIIIFSLLGMQLFGGKFNFDEM--------QTRRSTFDNFPQSLLTVFQILTGEDWNS 710
Query: 692 TLWD-CMEVAGQSW-----CIPFYLMVILIGNLLVLYLFLAL-VSSFSSCKDVTAEENNE 744
++D M G S+ CI +++++ + GN ++L +FLA+ V + + + +T+ + E
Sbjct: 711 VMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769
Query: 745 AKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDF 804
+ + K L +T + K + V++ + E +
Sbjct: 770 EEEKER--------------KKLARTASPEK------KQELVEKPAVGESKEEKIELKSI 809
Query: 805 LKDKEKSSGTEKNATE---NESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGG 861
D E T+ N + NE++ P P+ P +GE D E + + G
Sbjct: 810 TADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEE-------EPEMPVGP 857
Query: 862 SKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQ 921
+ + E + + + E F ++
Sbjct: 858 RPRPLSELHLKEKA---VPMPEASAFFIFSSNNR-------------------------- 888
Query: 922 NIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFIL 981
R C +IV + F I LLS+ +LA ED + +L AD +FT IF L
Sbjct: 889 -FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTL 946
Query: 982 EMLLKWMAYG---FKAYFSNGWYR-LDFVVVIVFCLS--LIGKTREELKPLISMKFLRPL 1035
E++LK AYG K F ++ LD +VV V +S + +K L ++ LRPL
Sbjct: 947 EIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPL 1006
Query: 1036 RVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPT--SG 1093
R +++ + +K VV+ + N+ +V ++ +F+ +GV LF G+ Y C D + +
Sbjct: 1007 RAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTE 1066
Query: 1094 ERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAID 1153
+ + K + WEN+K +FDNV ++L V+TF GW ++ +ID
Sbjct: 1067 AECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSID 1126
Query: 1154 SVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVK 1213
S + P + + + +FI +II F +++ + +I F + G + +
Sbjct: 1127 SHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQ-----GEQEYKNCE 1181
Query: 1214 QRKQYRRLKKLMYEDSQRPVPR--PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMID 1271
K R+ + Y RP+ R P N+ Q ++ VV S F ++ VLI I + +
Sbjct: 1182 LDKNQRQC--VEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1272 TDVQSLQMSIALYWINSIFVMLYTMECILKLIAFR-CFYFTIAWNIFDFMVVIFSITGLC 1330
QS IA+ +N +F L+T+E ILKLIAF+ YF AWN FD ++V+ SI +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1331 LPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLV 1390
+ + + L R++ +++L + L+ + S AL + LLI ++
Sbjct: 1300 ITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVML 1359
Query: 1391 MFIYAVFGMYNFAYV--KKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKW 1448
FIYAV GM F + IN +NF+TF ++L LF+ A W ++ A K
Sbjct: 1360 FFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGK- 1418
Query: 1449 SDCDPDKINPGTQVRGD--CGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKK 1506
C P+ P G+ CG+ S +FYF+S+ ++ +I+N+++ V+M+ + ++
Sbjct: 1419 -KCAPES-EPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDW 1475
Query: 1507 NKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAK--PNK---GQLIA 1561
+ L +F ++W +DP+ I + + PPL K P++ +L++
Sbjct: 1476 S-ILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVS 1534
Query: 1562 LDLPM 1566
+++P+
Sbjct: 1535 MNMPL 1539
Score = 153 bits (386), Expect = 2e-36
Identities = 156/684 (22%), Positives = 285/684 (41%), Gaps = 146/684 (21%)
Query: 95 ASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG- 153
AS S N R +++ F IL +L+ + ++ + P N +LG
Sbjct: 877 ASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED-PVQHTSFRNHILGN 935
Query: 154 -------IYTFEILVKLFARGVWAGSFSFLGDPWNWLDF---SVTVFEVIIRYSPLDFIP 203
I+T EI++K+ A G + SF + +N LD SV++ I+ S ++ +
Sbjct: 936 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 204 TLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNL 263
L+ R LR L+ I +GLK +V + ++ + ++I+T +F+ IG+ LF G L
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 264 KHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCV 323
+ C ++ E E N YI Y +GE + R
Sbjct: 1056 -YTCSDSSKQTEAECKGN------YIT------YKDGEVDHPIIQPR------------- 1089
Query: 324 KAGINPDQGFTNFDSFGWALFALFRLMA-QDYPEVLYHQI---LYASGKVY------MIF 373
+ + +FD+ A+ ALF + + +PE+LY I G +Y IF
Sbjct: 1090 ----SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1145
Query: 374 FVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKT 433
F++ + +F+M ++F+G + + ++E+ ++ E K
Sbjct: 1146 FIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ--------------------------EYKN 1179
Query: 434 IQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWY--KFAKTFLIWNCSPCW 491
+++ +R + E + K PL Y K + +W
Sbjct: 1180 CELDKNQRQCV--------------------EYALKARPLRRYIPKNQHQYKVW------ 1213
Query: 492 LKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAE 551
++ + + + + + I+LN L ++HY S +NI N++F G+FT E
Sbjct: 1214 --------YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVE 1265
Query: 552 MIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANV--------AGMALLRLFRMLRI 603
MI K+IA P YF WN FD++IV ++++ + V + RLFR++R+
Sbjct: 1266 MILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRL 1325
Query: 604 FKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKD 663
KL + L+W+ S+ AL + LL+ F A GM++FGK I+++
Sbjct: 1326 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRN 1385
Query: 664 CQLPRWHMHDFFHSFLNVFRILCGE-WVETLWDCM------------------EVAGQSW 704
+ F + L +FR GE W + + CM G S+
Sbjct: 1386 N-----NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSF 1440
Query: 705 CIPFYLMVILIGNLLVLYLFLALV 728
+ +++ ++ L++ LF+A++
Sbjct: 1441 AVFYFISFYMLCAFLIINLFVAVI 1464
Score = 71.2 bits (173), Expect = 8e-12
Identities = 86/392 (21%), Positives = 160/392 (40%), Gaps = 89/392 (22%)
Query: 1206 SNIFITVKQRKQYRRLKKLMYEDSQRPVPRPL------NKLQGFIFDVVTSQAFNVIVMV 1259
S + T ++R+QY + KK + RP PR L N ++ +V + F +I+++
Sbjct: 74 STVSSTQRKRQQYGKPKKQGSTTATRP-PRALLCLTLKNPIRRACISIVEWKPFEIIILL 132
Query: 1260 LICFQAIAMMIDT---DVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCF-----YFT 1311
I +A+ I + S + L + +F++++T+E LK+IA+ Y
Sbjct: 133 TIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLR 192
Query: 1312 IAWNIFDFMVVIFSITGLCLPMTV---GSYLVPPSL----VQLILLSRIIHMLRLGKGPK 1364
WN+ DF++V+ + L G+ + V+ + R++ LRL G
Sbjct: 193 NGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVP 252
Query: 1365 VFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF-----AYVKKEAGINDV----- 1414
++ ++ ++ LL+I LL+ V+ IYA+ G+ F + GI DV
Sbjct: 253 SLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDD 312
Query: 1415 -------------------------------SNFETFGNSMLCLFQVAIFAGWDGMLDAI 1443
+NF+ F +ML +FQ GW +L +
Sbjct: 313 PSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 1444 FNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVM-EFLNIA 1502
++ D YFV+ I+I ++N+ + V+ EF
Sbjct: 373 NDAVGRDWP--------------------WIYFVTLIIIGSFFVLNLVLGVLSGEF---- 408
Query: 1503 SKKKNKTLSEDDFRKFFQVWKRFDPDRTQYID 1534
SK++ K + DF+K + ++ + D Y+D
Sbjct: 409 SKEREKAKARGDFQKLREK-QQLEEDLKGYLD 439
>gi|193788540 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 16 [Homo sapiens]
Length = 2138
Score = 407 bits (1046), Expect = e-113
Identities = 399/1576 (25%), Positives = 705/1576 (44%), Gaps = 233/1576 (14%)
Query: 96 SILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSL-------------TNLPK 142
++LC L+ N IRR I ++ F++ IL+++ +CV +++ +NL +
Sbjct: 103 ALLC-LTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLER 161
Query: 143 WRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTV---FEVIIRYSPL 199
+E L I+T E +K+ A G+ ++L + WN LDF + V F I+ +
Sbjct: 162 ----VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK 217
Query: 200 DF-------------IPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLF 246
+ L+ R LR L+++ L+ ++ +I + L+ + +L LF
Sbjct: 218 ADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 277
Query: 247 FLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALL 306
+ I+++IG+ LFMG + C+ QE + +P
Sbjct: 278 VIIIYAIIGLELFMGKMHKTCYN--QEGIADVPAEDDPSP-------------------- 315
Query: 307 CGNRTDAG-QCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQD-YPEVLYHQILY 364
C T G QC G VC P G TNFD+F +A+ +F+ + + + +VLY +
Sbjct: 316 CALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYW-VND 374
Query: 365 ASGKVY-MIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRV---GEISKKIEPKFQQTGK 420
A G+ + I+FV + + SF++ +L LG+L+ + +E+++ G+ K E QQ +
Sbjct: 375 AVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREK--QQLEE 432
Query: 421 ELQ------------------EGNETDEAKTIQIEMKKRSPISTDTSL--DVL-EDATLR 459
+L+ EG + ++ + + + + ++T+ D+ E+ R
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 460 HKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNV 519
+ KSK F++ + WN C K + V + +I + LN
Sbjct: 493 LAHRISKSK---------FSRYWRRWNRF-CRRKCRAAVKSNVFY----WLVIFLVFLNT 538
Query: 520 CFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFH 579
+ EHY + + N + +FTAEM+ K+ ++ YF +N FD +V
Sbjct: 539 LTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCG 598
Query: 580 GLIELCLANVA-----GMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLL 634
G++E L G+++LR R+LRIFK+ +YW + L+ SL NS ++ L+LLL
Sbjct: 599 GILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLL 658
Query: 635 FTFIFFSAAFGMKLFGK--NYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVE 691
F FI + GM+LFG N++E Q R +F S L VF+IL GE W
Sbjct: 659 FLFIIIFSLLGMQLFGGKFNFDEM--------QTRRSTFDNFPQSLLTVFQILTGEDWNS 710
Query: 692 TLWD-CMEVAGQSW-----CIPFYLMVILIGNLLVLYLFLAL-VSSFSSCKDVTAEENNE 744
++D M G S+ CI +++++ + GN ++L +FLA+ V + + + +T+ + E
Sbjct: 711 VMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769
Query: 745 AKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDF 804
+ + K L +T + K + V++ + E +
Sbjct: 770 EEEKER--------------KKLARTASPEK------KQELVEKPAVGESKEEKIELKSI 809
Query: 805 LKDKEKSSGTEKNATE---NESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGG 861
D E T+ N + NE++ P P+ P +GE D E + + G
Sbjct: 810 TADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEE-------EPEMPVGP 857
Query: 862 SKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQ 921
+ + E + + + E F ++
Sbjct: 858 RPRPLSELHLKEKA---VPMPEASAFFIFSSNNR-------------------------- 888
Query: 922 NIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFIL 981
R C +IV + F I LLS+ +LA ED IL Y D++FT IF +
Sbjct: 889 -FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILF-YFDIVFTTIFTI 946
Query: 982 EMLLKWMAYG---FKAYFSNGWYR-LDFVVVIVFCLS--LIGKTREELKPLISMKFLRPL 1035
E+ LK AYG K F ++ LD +VV V +S + +K L ++ LRPL
Sbjct: 947 EIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPL 1006
Query: 1036 RVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPT--SG 1093
R +++ + +K VV+ + N+ +V ++ +F+ +GV LF G+ Y C D + +
Sbjct: 1007 RAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTE 1066
Query: 1094 ERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAID 1153
+ + K + WEN+K +FDNV ++L V+TF GW ++ +ID
Sbjct: 1067 AECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSID 1126
Query: 1154 SVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVK 1213
S + P + + + +FI +II F +++ + +I F + G + +
Sbjct: 1127 SHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQ-----GEQEYKNCE 1181
Query: 1214 QRKQYRRLKKLMYEDSQRPVPR--PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMID 1271
K R+ + Y RP+ R P N+ Q ++ VV S F ++ VLI I + +
Sbjct: 1182 LDKNQRQC--VEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1272 TDVQSLQMSIALYWINSIFVMLYTMECILKLIAFR-CFYFTIAWNIFDFMVVIFSITGLC 1330
QS IA+ +N +F L+T+E ILKLIAF+ YF+ WN+FDF++VI SI +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1331 LPMT--VGSYLVPPSL---------VQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPA 1379
L T PS+ + L R++ +++L + L+ + S A
Sbjct: 1300 LSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1380 LLNIILLIFLVMFIYAVFGMYNFAYV--KKEAGINDVSNFETFGNSMLCLFQVAIFAGWD 1437
L + LLI ++ FIYAV GM F + IN +NF+TF ++L LF+ A W
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1438 GMLDAIFNSKWSDCDPDKINPGTQVRGD--CGNPSVGIFYFVSYILISWLIIVNMYIVVV 1495
++ A K C P+ P G+ CG+ S +FYF+S+ ++ +I+N+++ V+
Sbjct: 1420 DIMLACMPGK--KCAPES-EPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1496 MEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAK-- 1553
M+ + ++ + L +F ++W +DP+ I + + PPL K
Sbjct: 1476 MDNFDYLTRDWS-ILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLC 1534
Query: 1554 PNK---GQLIALDLPM 1566
P++ +L+++++P+
Sbjct: 1535 PHRVACKRLVSMNMPL 1550
Score = 148 bits (373), Expect = 5e-35
Identities = 157/695 (22%), Positives = 284/695 (40%), Gaps = 157/695 (22%)
Query: 95 ASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLL-- 152
AS S N R +++ F IL +L+ + ++ + P N +L
Sbjct: 877 ASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED-PVQHTSFRNHILFY 935
Query: 153 ------GIYTFEILVKLFARGVWAGSFSFLGDPWNWLDF---SVTVFEVIIRYSPLDFIP 203
I+T EI +K+ A G + SF + +N LD SV++ I+ S ++ +
Sbjct: 936 FDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 204 TLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNL 263
L+ R LR L+ I +GLK +V + ++ + ++I+T +F+ IG+ LF G L
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 264 KHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCV 323
+ C ++ E E N YI Y +GE + R
Sbjct: 1056 -YTCSDSSKQTEAECKGN------YIT------YKDGEVDHPIIQPR------------- 1089
Query: 324 KAGINPDQGFTNFDSFGWALFALFRLMA-QDYPEVLYHQI---LYASGKVY------MIF 373
+ + +FD+ A+ ALF + + +PE+LY I G +Y IF
Sbjct: 1090 ----SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1145
Query: 374 FVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKT 433
F++ + +F+M ++F+G + + ++E+ ++ E K
Sbjct: 1146 FIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ--------------------------EYKN 1179
Query: 434 IQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWY--KFAKTFLIWNCSPCW 491
+++ +R + E + K PL Y K + +W
Sbjct: 1180 CELDKNQRQCV--------------------EYALKARPLRRYIPKNQHQYKVW------ 1213
Query: 492 LKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAE 551
++ + + + + + I+LN L ++HY S +NI N++F G+FT E
Sbjct: 1214 --------YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVE 1265
Query: 552 MIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANV-------------------AGM 592
MI K+IA P GYF WN+FD +IV +I++ L+ +
Sbjct: 1266 MILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISI 1325
Query: 593 ALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
RLFR++R+ KL + L+W+ S+ AL + LL+ F A GM++FGK
Sbjct: 1326 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI 1385
Query: 653 YEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVETLWDCM-------------- 697
I+++ + F + L +FR GE W + + CM
Sbjct: 1386 ALNDTTEINRNN-----NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNS 1440
Query: 698 ----EVAGQSWCIPFYLMVILIGNLLVLYLFLALV 728
G S+ + +++ ++ L++ LF+A++
Sbjct: 1441 TEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Score = 71.2 bits (173), Expect = 8e-12
Identities = 86/392 (21%), Positives = 160/392 (40%), Gaps = 89/392 (22%)
Query: 1206 SNIFITVKQRKQYRRLKKLMYEDSQRPVPRPL------NKLQGFIFDVVTSQAFNVIVMV 1259
S + T ++R+QY + KK + RP PR L N ++ +V + F +I+++
Sbjct: 74 STVSSTQRKRQQYGKPKKQGSTTATRP-PRALLCLTLKNPIRRACISIVEWKPFEIIILL 132
Query: 1260 LICFQAIAMMIDT---DVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCF-----YFT 1311
I +A+ I + S + L + +F++++T+E LK+IA+ Y
Sbjct: 133 TIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLR 192
Query: 1312 IAWNIFDFMVVIFSITGLCLPMTV---GSYLVPPSL----VQLILLSRIIHMLRLGKGPK 1364
WN+ DF++V+ + L G+ + V+ + R++ LRL G
Sbjct: 193 NGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVP 252
Query: 1365 VFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF-----AYVKKEAGINDV----- 1414
++ ++ ++ LL+I LL+ V+ IYA+ G+ F + GI DV
Sbjct: 253 SLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDD 312
Query: 1415 -------------------------------SNFETFGNSMLCLFQVAIFAGWDGMLDAI 1443
+NF+ F +ML +FQ GW +L +
Sbjct: 313 PSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 1444 FNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVM-EFLNIA 1502
++ D YFV+ I+I ++N+ + V+ EF
Sbjct: 373 NDAVGRDWP--------------------WIYFVTLIIIGSFFVLNLVLGVLSGEF---- 408
Query: 1503 SKKKNKTLSEDDFRKFFQVWKRFDPDRTQYID 1534
SK++ K + DF+K + ++ + D Y+D
Sbjct: 409 SKEREKAKARGDFQKLREK-QQLEEDLKGYLD 439
>gi|193788538 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 15 [Homo sapiens]
Length = 2138
Score = 407 bits (1046), Expect = e-113
Identities = 399/1576 (25%), Positives = 706/1576 (44%), Gaps = 233/1576 (14%)
Query: 96 SILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSL-------------TNLPK 142
++LC L+ N IRR I ++ F++ IL+++ +CV +++ +NL +
Sbjct: 103 ALLC-LTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLER 161
Query: 143 WRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTV---FEVIIRYSPL 199
+E L I+T E +K+ A G+ ++L + WN LDF + V F I+ +
Sbjct: 162 ----VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK 217
Query: 200 DF-------------IPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLF 246
+ L+ R LR L+++ L+ ++ +I + L+ + +L LF
Sbjct: 218 ADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 277
Query: 247 FLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALL 306
+ I+++IG+ LFMG + C+ QE + +P
Sbjct: 278 VIIIYAIIGLELFMGKMHKTCYN--QEGIADVPAEDDPSP-------------------- 315
Query: 307 CGNRTDAG-QCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQD-YPEVLYHQILY 364
C T G QC G VC P G TNFD+F +A+ +F+ + + + +VLY +
Sbjct: 316 CALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYW-VND 374
Query: 365 ASGKVY-MIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRV---GEISKKIEPKFQQTGK 420
A G+ + I+FV + + SF++ +L LG+L+ + +E+++ G+ K E QQ +
Sbjct: 375 AVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREK--QQLEE 432
Query: 421 ELQ------------------EGNETDEAKTIQIEMKKRSPISTDTSL--DVL-EDATLR 459
+L+ EG + ++ + + + + ++T+ D+ E+ R
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 460 HKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNV 519
+ KSK F++ + WN C K + V + +I + LN
Sbjct: 493 LAHRISKSK---------FSRYWRRWNRF-CRRKCRAAVKSNVFY----WLVIFLVFLNT 538
Query: 520 CFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFH 579
+ EHY + + N + +FTAEM+ K+ ++ YF +N FD +V
Sbjct: 539 LTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCG 598
Query: 580 GLIELCLANVA-----GMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLL 634
G++E L G+++LR R+LRIFK+ +YW + L+ SL NS ++ L+LLL
Sbjct: 599 GILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLL 658
Query: 635 FTFIFFSAAFGMKLFGK--NYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVE 691
F FI + GM+LFG N++E Q R +F S L VF+IL GE W
Sbjct: 659 FLFIIIFSLLGMQLFGGKFNFDEM--------QTRRSTFDNFPQSLLTVFQILTGEDWNS 710
Query: 692 TLWD-CMEVAGQSW-----CIPFYLMVILIGNLLVLYLFLAL-VSSFSSCKDVTAEENNE 744
++D M G S+ CI +++++ + GN ++L +FLA+ V + + + +T+ + E
Sbjct: 711 VMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769
Query: 745 AKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDF 804
+ + K L +T + K + V++ + E +
Sbjct: 770 EEEKER--------------KKLARTASPEK------KQELVEKPAVGESKEEKIELKSI 809
Query: 805 LKDKEKSSGTEKNATE---NESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGG 861
D E T+ N + NE++ P P+ P +GE D E + + G
Sbjct: 810 TADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEE-------EPEMPVGP 857
Query: 862 SKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQ 921
+ + E + + + E F ++
Sbjct: 858 RPRPLSELHLKEKA---VPMPEASAFFIFSSNNR-------------------------- 888
Query: 922 NIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFIL 981
R C +IV + F I LLS+ +LA ED + +L AD +FT IF L
Sbjct: 889 -FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTL 946
Query: 982 EMLLKWMAYG---FKAYFSNGWYR-LDFVVVIVFCLS--LIGKTREELKPLISMKFLRPL 1035
E++LK AYG K F ++ LD +VV V +S + +K L ++ LRPL
Sbjct: 947 EIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPL 1006
Query: 1036 RVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPT--SG 1093
R +++ + +K VV+ + N+ +V ++ +F+ +GV LF G+ Y C D + +
Sbjct: 1007 RAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTE 1066
Query: 1094 ERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAID 1153
+ + K + WEN+K +FDNV ++L V+TF GW ++ +ID
Sbjct: 1067 AECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSID 1126
Query: 1154 SVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVK 1213
S + P + + + +FI +II F +++ + +I F + G + +
Sbjct: 1127 SHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQ-----GEQEYKNCE 1181
Query: 1214 QRKQYRRLKKLMYEDSQRPVPR--PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMID 1271
K R+ + Y RP+ R P N+ Q ++ VV S F ++ VLI I + +
Sbjct: 1182 LDKNQRQC--VEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1272 TDVQSLQMSIALYWINSIFVMLYTMECILKLIAFR-CFYFTIAWNIFDFMVVIFSITGLC 1330
QS IA+ +N +F L+T+E ILKLIAF+ YF+ WN+FDF++VI SI +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1331 LPMT--VGSYLVPPSL---------VQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPA 1379
L T PS+ + L R++ +++L + L+ + S A
Sbjct: 1300 LSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1380 LLNIILLIFLVMFIYAVFGMYNFAYV--KKEAGINDVSNFETFGNSMLCLFQVAIFAGWD 1437
L + LLI ++ FIYAV GM F + IN +NF+TF ++L LF+ A W
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1438 GMLDAIFNSKWSDCDPDKINPGTQVRGD--CGNPSVGIFYFVSYILISWLIIVNMYIVVV 1495
++ A K C P+ P G+ CG+ S +FYF+S+ ++ +I+N+++ V+
Sbjct: 1420 DIMLACMPGK--KCAPES-EPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1496 MEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAK-- 1553
M+ + ++ + L +F ++W +DP+ I + + PPL K
Sbjct: 1476 MDNFDYLTRDWS-ILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLC 1534
Query: 1554 PNK---GQLIALDLPM 1566
P++ +L+++++P+
Sbjct: 1535 PHRVACKRLVSMNMPL 1550
Score = 152 bits (384), Expect = 3e-36
Identities = 158/695 (22%), Positives = 286/695 (41%), Gaps = 157/695 (22%)
Query: 95 ASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG- 153
AS S N R +++ F IL +L+ + ++ + P N +LG
Sbjct: 877 ASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED-PVQHTSFRNHILGN 935
Query: 154 -------IYTFEILVKLFARGVWAGSFSFLGDPWNWLDF---SVTVFEVIIRYSPLDFIP 203
I+T EI++K+ A G + SF + +N LD SV++ I+ S ++ +
Sbjct: 936 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 204 TLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNL 263
L+ R LR L+ I +GLK +V + ++ + ++I+T +F+ IG+ LF G L
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 264 KHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCV 323
+ C ++ E E N YI Y +GE + R
Sbjct: 1056 -YTCSDSSKQTEAECKGN------YIT------YKDGEVDHPIIQPR------------- 1089
Query: 324 KAGINPDQGFTNFDSFGWALFALFRLMA-QDYPEVLYHQI---LYASGKVY------MIF 373
+ + +FD+ A+ ALF + + +PE+LY I G +Y IF
Sbjct: 1090 ----SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1145
Query: 374 FVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKT 433
F++ + +F+M ++F+G + + ++E+ ++ E K
Sbjct: 1146 FIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ--------------------------EYKN 1179
Query: 434 IQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWY--KFAKTFLIWNCSPCW 491
+++ +R + E + K PL Y K + +W
Sbjct: 1180 CELDKNQRQCV--------------------EYALKARPLRRYIPKNQHQYKVW------ 1213
Query: 492 LKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAE 551
++ + + + + + I+LN L ++HY S +NI N++F G+FT E
Sbjct: 1214 --------YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVE 1265
Query: 552 MIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANV-------------------AGM 592
MI K+IA P GYF WN+FD +IV +I++ L+ +
Sbjct: 1266 MILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISI 1325
Query: 593 ALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
RLFR++R+ KL + L+W+ S+ AL + LL+ F A GM++FGK
Sbjct: 1326 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI 1385
Query: 653 YEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVETLWDCM-------------- 697
I+++ + F + L +FR GE W + + CM
Sbjct: 1386 ALNDTTEINRNN-----NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNS 1440
Query: 698 ----EVAGQSWCIPFYLMVILIGNLLVLYLFLALV 728
G S+ + +++ ++ L++ LF+A++
Sbjct: 1441 TEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Score = 71.2 bits (173), Expect = 8e-12
Identities = 86/392 (21%), Positives = 160/392 (40%), Gaps = 89/392 (22%)
Query: 1206 SNIFITVKQRKQYRRLKKLMYEDSQRPVPRPL------NKLQGFIFDVVTSQAFNVIVMV 1259
S + T ++R+QY + KK + RP PR L N ++ +V + F +I+++
Sbjct: 74 STVSSTQRKRQQYGKPKKQGSTTATRP-PRALLCLTLKNPIRRACISIVEWKPFEIIILL 132
Query: 1260 LICFQAIAMMIDT---DVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCF-----YFT 1311
I +A+ I + S + L + +F++++T+E LK+IA+ Y
Sbjct: 133 TIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLR 192
Query: 1312 IAWNIFDFMVVIFSITGLCLPMTV---GSYLVPPSL----VQLILLSRIIHMLRLGKGPK 1364
WN+ DF++V+ + L G+ + V+ + R++ LRL G
Sbjct: 193 NGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVP 252
Query: 1365 VFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF-----AYVKKEAGINDV----- 1414
++ ++ ++ LL+I LL+ V+ IYA+ G+ F + GI DV
Sbjct: 253 SLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDD 312
Query: 1415 -------------------------------SNFETFGNSMLCLFQVAIFAGWDGMLDAI 1443
+NF+ F +ML +FQ GW +L +
Sbjct: 313 PSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 1444 FNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVM-EFLNIA 1502
++ D YFV+ I+I ++N+ + V+ EF
Sbjct: 373 NDAVGRDWP--------------------WIYFVTLIIIGSFFVLNLVLGVLSGEF---- 408
Query: 1503 SKKKNKTLSEDDFRKFFQVWKRFDPDRTQYID 1534
SK++ K + DF+K + ++ + D Y+D
Sbjct: 409 SKEREKAKARGDFQKLREK-QQLEEDLKGYLD 439
>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 12 [Homo sapiens]
Length = 2146
Score = 407 bits (1046), Expect = e-113
Identities = 394/1565 (25%), Positives = 701/1565 (44%), Gaps = 222/1565 (14%)
Query: 96 SILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSL-------------TNLPK 142
++LC L+ N IRR I ++ F++ IL+++ +CV +++ +NL +
Sbjct: 103 ALLC-LTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLER 161
Query: 143 WRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTV---FEVIIRYSPL 199
+E L I+T E +K+ A G+ ++L + WN LDF + V F I+ +
Sbjct: 162 ----VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK 217
Query: 200 DF-------------IPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLF 246
+ L+ R LR L+++ L+ ++ +I + L+ + +L LF
Sbjct: 218 ADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 277
Query: 247 FLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALL 306
+ I+++IG+ LFMG + C+ QE + +P
Sbjct: 278 VIIIYAIIGLELFMGKMHKTCYN--QEGIADVPAEDDPSP-------------------- 315
Query: 307 CGNRTDAG-QCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQD-YPEVLYHQILY 364
C T G QC G VC P G TNFD+F +A+ +F+ + + + +VLY +
Sbjct: 316 CALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYW-VND 374
Query: 365 ASGKVY-MIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRV---GEISKKIEPKFQQTGK 420
A G+ + I+FV + + SF++ +L LG+L+ + +E+++ G+ K E QQ +
Sbjct: 375 AVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREK--QQLEE 432
Query: 421 ELQ------------------EGNETDEAKTIQIEMKKRSPISTDTSL--DVL-EDATLR 459
+L+ EG + ++ + + + + ++T+ D+ E+ R
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 460 HKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNV 519
+ KSK F++ + WN C K + V + +I + LN
Sbjct: 493 LAHRISKSK---------FSRYWRRWNRF-CRRKCRAAVKSNVFY----WLVIFLVFLNT 538
Query: 520 CFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFH 579
+ EHY + + N + +FTAEM+ K+ ++ YF +N FD +V
Sbjct: 539 LTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCG 598
Query: 580 GLIELCLANVA-----GMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLL 634
G++E L G+++LR R+LRIFK+ +YW + L+ SL NS ++ L+LLL
Sbjct: 599 GILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLL 658
Query: 635 FTFIFFSAAFGMKLFGK--NYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVE 691
F FI + GM+LFG N++E Q R +F S L VF+IL GE W
Sbjct: 659 FLFIIIFSLLGMQLFGGKFNFDEM--------QTRRSTFDNFPQSLLTVFQILTGEDWNS 710
Query: 692 TLWD-CMEVAGQSW-----CIPFYLMVILIGNLLVLYLFLAL-VSSFSSCKDVTAEENNE 744
++D M G S+ CI +++++ + GN ++L +FLA+ V + + + +T+ + E
Sbjct: 711 VMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769
Query: 745 AKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDF 804
+ + K L +T + K + V++ + E +
Sbjct: 770 EEEKER--------------KKLARTASPEK------KQELVEKPAVGESKEEKIELKSI 809
Query: 805 LKDKEKSSGTEKNATE---NESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGG 861
D E T+ N + NE++ P P+ P +GE D E + + G
Sbjct: 810 TADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEE-------EPEMPVGP 857
Query: 862 SKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQ 921
+ + E + + + E F ++
Sbjct: 858 RPRPLSELHLKEKA---VPMPEASAFFIFSSNNR-------------------------- 888
Query: 922 NIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFIL 981
R C +IV + F I LLS+ +LA ED + +L AD +FT IF L
Sbjct: 889 -FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTL 946
Query: 982 EMLLKWMAYG---FKAYFSNGWYR-LDFVVVIVFCLS--LIGKTREELKPLISMKFLRPL 1035
E++LK AYG K F ++ LD +VV V +S + +K L ++ LRPL
Sbjct: 947 EIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPL 1006
Query: 1036 RVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPT--SG 1093
R +++ + +K VV+ + N+ +V ++ +F+ +GV LF G+ Y C D + +
Sbjct: 1007 RAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTE 1066
Query: 1094 ERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAID 1153
+ + K + WEN+K +FDNV ++L V+TF GW ++ +ID
Sbjct: 1067 AECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSID 1126
Query: 1154 SVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVK 1213
S + P + + + +FI +II F +++ + +I F + G + +
Sbjct: 1127 SHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQ-----GEQEYKNCE 1181
Query: 1214 QRKQYRRLKKLMYEDSQRPVPR--PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMID 1271
K R+ + Y RP+ R P N+ Q ++ VV S F ++ VLI I + +
Sbjct: 1182 LDKNQRQC--VEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1272 TDVQSLQMSIALYWINSIFVMLYTMECILKLIAFR-CFYFTIAWNIFDFMVVIFSITGLC 1330
QS IA+ +N +F L+T+E ILKLIAF+ YF AWN FD ++V+ SI +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1331 LPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLV 1390
+ + + L R++ +++L + L+ + S AL + LLI ++
Sbjct: 1300 ITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVML 1359
Query: 1391 MFIYAVFGMYNFAYV--KKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKW 1448
FIYAV GM F + IN +NF+TF ++L LF+ A W ++ A K
Sbjct: 1360 FFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGK- 1418
Query: 1449 SDCDPDKINPGTQVRGD--CGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKK 1506
C P+ P G+ CG+ S +FYF+S+ ++ +I+N+++ V+M+ + ++
Sbjct: 1419 -KCAPES-EPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDW 1475
Query: 1507 NKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAK--PNK---GQLIA 1561
+ L +F ++W +DP+ I + + PPL K P++ +L++
Sbjct: 1476 S-ILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVS 1534
Query: 1562 LDLPM 1566
+++P+
Sbjct: 1535 MNMPL 1539
Score = 153 bits (386), Expect = 2e-36
Identities = 156/684 (22%), Positives = 285/684 (41%), Gaps = 146/684 (21%)
Query: 95 ASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG- 153
AS S N R +++ F IL +L+ + ++ + P N +LG
Sbjct: 877 ASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED-PVQHTSFRNHILGN 935
Query: 154 -------IYTFEILVKLFARGVWAGSFSFLGDPWNWLDF---SVTVFEVIIRYSPLDFIP 203
I+T EI++K+ A G + SF + +N LD SV++ I+ S ++ +
Sbjct: 936 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 204 TLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNL 263
L+ R LR L+ I +GLK +V + ++ + ++I+T +F+ IG+ LF G L
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 264 KHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCV 323
+ C ++ E E N YI Y +GE + R
Sbjct: 1056 -YTCSDSSKQTEAECKGN------YIT------YKDGEVDHPIIQPR------------- 1089
Query: 324 KAGINPDQGFTNFDSFGWALFALFRLMA-QDYPEVLYHQI---LYASGKVY------MIF 373
+ + +FD+ A+ ALF + + +PE+LY I G +Y IF
Sbjct: 1090 ----SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1145
Query: 374 FVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKT 433
F++ + +F+M ++F+G + + ++E+ ++ E K
Sbjct: 1146 FIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ--------------------------EYKN 1179
Query: 434 IQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWY--KFAKTFLIWNCSPCW 491
+++ +R + E + K PL Y K + +W
Sbjct: 1180 CELDKNQRQCV--------------------EYALKARPLRRYIPKNQHQYKVW------ 1213
Query: 492 LKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAE 551
++ + + + + + I+LN L ++HY S +NI N++F G+FT E
Sbjct: 1214 --------YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVE 1265
Query: 552 MIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANV--------AGMALLRLFRMLRI 603
MI K+IA P YF WN FD++IV ++++ + V + RLFR++R+
Sbjct: 1266 MILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRL 1325
Query: 604 FKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKD 663
KL + L+W+ S+ AL + LL+ F A GM++FGK I+++
Sbjct: 1326 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRN 1385
Query: 664 CQLPRWHMHDFFHSFLNVFRILCGE-WVETLWDCM------------------EVAGQSW 704
+ F + L +FR GE W + + CM G S+
Sbjct: 1386 N-----NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSF 1440
Query: 705 CIPFYLMVILIGNLLVLYLFLALV 728
+ +++ ++ L++ LF+A++
Sbjct: 1441 AVFYFISFYMLCAFLIINLFVAVI 1464
Score = 71.2 bits (173), Expect = 8e-12
Identities = 86/392 (21%), Positives = 160/392 (40%), Gaps = 89/392 (22%)
Query: 1206 SNIFITVKQRKQYRRLKKLMYEDSQRPVPRPL------NKLQGFIFDVVTSQAFNVIVMV 1259
S + T ++R+QY + KK + RP PR L N ++ +V + F +I+++
Sbjct: 74 STVSSTQRKRQQYGKPKKQGSTTATRP-PRALLCLTLKNPIRRACISIVEWKPFEIIILL 132
Query: 1260 LICFQAIAMMIDT---DVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCF-----YFT 1311
I +A+ I + S + L + +F++++T+E LK+IA+ Y
Sbjct: 133 TIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLR 192
Query: 1312 IAWNIFDFMVVIFSITGLCLPMTV---GSYLVPPSL----VQLILLSRIIHMLRLGKGPK 1364
WN+ DF++V+ + L G+ + V+ + R++ LRL G
Sbjct: 193 NGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVP 252
Query: 1365 VFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF-----AYVKKEAGINDV----- 1414
++ ++ ++ LL+I LL+ V+ IYA+ G+ F + GI DV
Sbjct: 253 SLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDD 312
Query: 1415 -------------------------------SNFETFGNSMLCLFQVAIFAGWDGMLDAI 1443
+NF+ F +ML +FQ GW +L +
Sbjct: 313 PSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 1444 FNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVM-EFLNIA 1502
++ D YFV+ I+I ++N+ + V+ EF
Sbjct: 373 NDAVGRDWP--------------------WIYFVTLIIIGSFFVLNLVLGVLSGEF---- 408
Query: 1503 SKKKNKTLSEDDFRKFFQVWKRFDPDRTQYID 1534
SK++ K + DF+K + ++ + D Y+D
Sbjct: 409 SKEREKAKARGDFQKLREK-QQLEEDLKGYLD 439
>gi|193788532 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 11 [Homo sapiens]
Length = 2146
Score = 407 bits (1046), Expect = e-113
Identities = 394/1565 (25%), Positives = 700/1565 (44%), Gaps = 222/1565 (14%)
Query: 96 SILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSL-------------TNLPK 142
++LC L+ N IRR I ++ F++ IL+++ +CV +++ +NL +
Sbjct: 103 ALLC-LTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLER 161
Query: 143 WRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTV---FEVIIRYSPL 199
+E L I+T E +K+ A G+ ++L + WN LDF + V F I+ +
Sbjct: 162 ----VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK 217
Query: 200 DF-------------IPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLF 246
+ L+ R LR L+++ L+ ++ +I + L+ + +L LF
Sbjct: 218 ADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 277
Query: 247 FLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALL 306
+ I+++IG+ LFMG + C+ QE + +P
Sbjct: 278 VIIIYAIIGLELFMGKMHKTCYN--QEGIADVPAEDDPSP-------------------- 315
Query: 307 CGNRTDAG-QCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQD-YPEVLYHQILY 364
C T G QC G VC P G TNFD+F +A+ +F+ + + + +VLY +
Sbjct: 316 CALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYW-VND 374
Query: 365 ASGKVY-MIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRV---GEISKKIEPKFQQTGK 420
A G+ + I+FV + + SF++ +L LG+L+ + +E+++ G+ K E QQ +
Sbjct: 375 AVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREK--QQLEE 432
Query: 421 ELQ------------------EGNETDEAKTIQIEMKKRSPISTDTSL--DVL-EDATLR 459
+L+ EG + ++ + + + + ++T+ D+ E+ R
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 460 HKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNV 519
+ KSK F++ + WN C K + V + +I + LN
Sbjct: 493 LAHRISKSK---------FSRYWRRWNRF-CRRKCRAAVKSNVFY----WLVIFLVFLNT 538
Query: 520 CFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFH 579
+ EHY + + N + +FTAEM+ K+ ++ YF +N FD +V
Sbjct: 539 LTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCG 598
Query: 580 GLIELCLANVA-----GMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLL 634
G++E L G+++LR R+LRIFK+ +YW + L+ SL NS ++ L+LLL
Sbjct: 599 GILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLL 658
Query: 635 FTFIFFSAAFGMKLFGK--NYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVE 691
F FI + GM+LFG N++E Q R +F S L VF+IL GE W
Sbjct: 659 FLFIIIFSLLGMQLFGGKFNFDEM--------QTRRSTFDNFPQSLLTVFQILTGEDWNS 710
Query: 692 TLWD-CMEVAGQSW-----CIPFYLMVILIGNLLVLYLFLAL-VSSFSSCKDVTAEENNE 744
++D M G S+ CI +++++ + GN ++L +FLA+ V + + + +T+ + E
Sbjct: 711 VMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769
Query: 745 AKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDF 804
+ + K L +T + K + V++ + E +
Sbjct: 770 EEEKER--------------KKLARTASPEK------KQELVEKPAVGESKEEKIELKSI 809
Query: 805 LKDKEKSSGTEKNATE---NESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGG 861
D E T+ N + NE++ P P+ P +GE D E + + G
Sbjct: 810 TADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEE-------EPEMPVGP 857
Query: 862 SKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQ 921
+ + E + + + E F ++
Sbjct: 858 RPRPLSELHLKEKA---VPMPEASAFFIFSSNNR-------------------------- 888
Query: 922 NIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFIL 981
R C +IV + F I LLS+ +LA ED IL Y D++FT IF +
Sbjct: 889 -FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILF-YFDIVFTTIFTI 946
Query: 982 EMLLKWMAYG---FKAYFSNGWYR-LDFVVVIVFCLS--LIGKTREELKPLISMKFLRPL 1035
E+ LK AYG K F ++ LD +VV V +S + +K L ++ LRPL
Sbjct: 947 EIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPL 1006
Query: 1036 RVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPT--SG 1093
R +++ + +K VV+ + N+ +V ++ +F+ +GV LF G+ Y C D + +
Sbjct: 1007 RAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTE 1066
Query: 1094 ERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAID 1153
+ + K + WEN+K +FDNV ++L V+TF GW ++ +ID
Sbjct: 1067 AECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSID 1126
Query: 1154 SVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVK 1213
S + P + + + +FI +II F +++ + +I F + G + +
Sbjct: 1127 SHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQ-----GEQEYKNCE 1181
Query: 1214 QRKQYRRLKKLMYEDSQRPVPR--PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMID 1271
K R+ + Y RP+ R P N+ Q ++ VV S F ++ VLI I + +
Sbjct: 1182 LDKNQRQC--VEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1272 TDVQSLQMSIALYWINSIFVMLYTMECILKLIAFR-CFYFTIAWNIFDFMVVIFSITGLC 1330
QS IA+ +N +F L+T+E ILKLIAF+ YF AWN FD ++V+ SI +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1331 LPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLV 1390
+ + + L R++ +++L + L+ + S AL + LLI ++
Sbjct: 1300 ITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVML 1359
Query: 1391 MFIYAVFGMYNFAYV--KKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKW 1448
FIYAV GM F + IN +NF+TF ++L LF+ A W ++ A K
Sbjct: 1360 FFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGK- 1418
Query: 1449 SDCDPDKINPGTQVRGD--CGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKK 1506
C P+ P G+ CG+ S +FYF+S+ ++ +I+N+++ V+M+ + ++
Sbjct: 1419 -KCAPES-EPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDW 1475
Query: 1507 NKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAK--PNK---GQLIA 1561
+ L +F ++W +DP+ I + + PPL K P++ +L++
Sbjct: 1476 S-ILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVS 1534
Query: 1562 LDLPM 1566
+++P+
Sbjct: 1535 MNMPL 1539
Score = 149 bits (375), Expect = 3e-35
Identities = 155/684 (22%), Positives = 283/684 (41%), Gaps = 146/684 (21%)
Query: 95 ASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLL-- 152
AS S N R +++ F IL +L+ + ++ + P N +L
Sbjct: 877 ASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED-PVQHTSFRNHILFY 935
Query: 153 ------GIYTFEILVKLFARGVWAGSFSFLGDPWNWLDF---SVTVFEVIIRYSPLDFIP 203
I+T EI +K+ A G + SF + +N LD SV++ I+ S ++ +
Sbjct: 936 FDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 204 TLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNL 263
L+ R LR L+ I +GLK +V + ++ + ++I+T +F+ IG+ LF G L
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 264 KHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCV 323
+ C ++ E E N YI Y +GE + R
Sbjct: 1056 -YTCSDSSKQTEAECKGN------YIT------YKDGEVDHPIIQPR------------- 1089
Query: 324 KAGINPDQGFTNFDSFGWALFALFRLMA-QDYPEVLYHQI---LYASGKVY------MIF 373
+ + +FD+ A+ ALF + + +PE+LY I G +Y IF
Sbjct: 1090 ----SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1145
Query: 374 FVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKT 433
F++ + +F+M ++F+G + + ++E+ ++ E K
Sbjct: 1146 FIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ--------------------------EYKN 1179
Query: 434 IQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWY--KFAKTFLIWNCSPCW 491
+++ +R + E + K PL Y K + +W
Sbjct: 1180 CELDKNQRQCV--------------------EYALKARPLRRYIPKNQHQYKVW------ 1213
Query: 492 LKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAE 551
++ + + + + + I+LN L ++HY S +NI N++F G+FT E
Sbjct: 1214 --------YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVE 1265
Query: 552 MIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANV--------AGMALLRLFRMLRI 603
MI K+IA P YF WN FD++IV ++++ + V + RLFR++R+
Sbjct: 1266 MILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRL 1325
Query: 604 FKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKD 663
KL + L+W+ S+ AL + LL+ F A GM++FGK I+++
Sbjct: 1326 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRN 1385
Query: 664 CQLPRWHMHDFFHSFLNVFRILCGE-WVETLWDCM------------------EVAGQSW 704
+ F + L +FR GE W + + CM G S+
Sbjct: 1386 N-----NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSF 1440
Query: 705 CIPFYLMVILIGNLLVLYLFLALV 728
+ +++ ++ L++ LF+A++
Sbjct: 1441 AVFYFISFYMLCAFLIINLFVAVI 1464
Score = 71.2 bits (173), Expect = 8e-12
Identities = 86/392 (21%), Positives = 160/392 (40%), Gaps = 89/392 (22%)
Query: 1206 SNIFITVKQRKQYRRLKKLMYEDSQRPVPRPL------NKLQGFIFDVVTSQAFNVIVMV 1259
S + T ++R+QY + KK + RP PR L N ++ +V + F +I+++
Sbjct: 74 STVSSTQRKRQQYGKPKKQGSTTATRP-PRALLCLTLKNPIRRACISIVEWKPFEIIILL 132
Query: 1260 LICFQAIAMMIDT---DVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCF-----YFT 1311
I +A+ I + S + L + +F++++T+E LK+IA+ Y
Sbjct: 133 TIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLR 192
Query: 1312 IAWNIFDFMVVIFSITGLCLPMTV---GSYLVPPSL----VQLILLSRIIHMLRLGKGPK 1364
WN+ DF++V+ + L G+ + V+ + R++ LRL G
Sbjct: 193 NGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVP 252
Query: 1365 VFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF-----AYVKKEAGINDV----- 1414
++ ++ ++ LL+I LL+ V+ IYA+ G+ F + GI DV
Sbjct: 253 SLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDD 312
Query: 1415 -------------------------------SNFETFGNSMLCLFQVAIFAGWDGMLDAI 1443
+NF+ F +ML +FQ GW +L +
Sbjct: 313 PSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 1444 FNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVM-EFLNIA 1502
++ D YFV+ I+I ++N+ + V+ EF
Sbjct: 373 NDAVGRDWP--------------------WIYFVTLIIIGSFFVLNLVLGVLSGEF---- 408
Query: 1503 SKKKNKTLSEDDFRKFFQVWKRFDPDRTQYID 1534
SK++ K + DF+K + ++ + D Y+D
Sbjct: 409 SKEREKAKARGDFQKLREK-QQLEEDLKGYLD 439
>gi|193794828 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 7 [Homo sapiens]
Length = 2157
Score = 407 bits (1046), Expect = e-113
Identities = 399/1576 (25%), Positives = 705/1576 (44%), Gaps = 233/1576 (14%)
Query: 96 SILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSL-------------TNLPK 142
++LC L+ N IRR I ++ F++ IL+++ +CV +++ +NL +
Sbjct: 103 ALLC-LTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLER 161
Query: 143 WRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTV---FEVIIRYSPL 199
+E L I+T E +K+ A G+ ++L + WN LDF + V F I+ +
Sbjct: 162 ----VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK 217
Query: 200 DF-------------IPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLF 246
+ L+ R LR L+++ L+ ++ +I + L+ + +L LF
Sbjct: 218 ADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 277
Query: 247 FLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALL 306
+ I+++IG+ LFMG + C+ QE + +P
Sbjct: 278 VIIIYAIIGLELFMGKMHKTCYN--QEGIADVPAEDDPSP-------------------- 315
Query: 307 CGNRTDAG-QCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQD-YPEVLYHQILY 364
C T G QC G VC P G TNFD+F +A+ +F+ + + + +VLY +
Sbjct: 316 CALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYW-VND 374
Query: 365 ASGKVY-MIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRV---GEISKKIEPKFQQTGK 420
A G+ + I+FV + + SF++ +L LG+L+ + +E+++ G+ K E QQ +
Sbjct: 375 AVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREK--QQLEE 432
Query: 421 ELQ------------------EGNETDEAKTIQIEMKKRSPISTDTSL--DVL-EDATLR 459
+L+ EG + ++ + + + + ++T+ D+ E+ R
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 460 HKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNV 519
+ KSK F++ + WN C K + V + +I + LN
Sbjct: 493 LAHRISKSK---------FSRYWRRWNRF-CRRKCRAAVKSNVFY----WLVIFLVFLNT 538
Query: 520 CFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFH 579
+ EHY + + N + +FTAEM+ K+ ++ YF +N FD +V
Sbjct: 539 LTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCG 598
Query: 580 GLIELCLANVA-----GMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLL 634
G++E L G+++LR R+LRIFK+ +YW + L+ SL NS ++ L+LLL
Sbjct: 599 GILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLL 658
Query: 635 FTFIFFSAAFGMKLFGK--NYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVE 691
F FI + GM+LFG N++E Q R +F S L VF+IL GE W
Sbjct: 659 FLFIIIFSLLGMQLFGGKFNFDEM--------QTRRSTFDNFPQSLLTVFQILTGEDWNS 710
Query: 692 TLWD-CMEVAGQSW-----CIPFYLMVILIGNLLVLYLFLAL-VSSFSSCKDVTAEENNE 744
++D M G S+ CI +++++ + GN ++L +FLA+ V + + + +T+ + E
Sbjct: 711 VMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769
Query: 745 AKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDF 804
+ + K L +T + K + V++ + E +
Sbjct: 770 EEEKER--------------KKLARTASPEK------KQELVEKPAVGESKEEKIELKSI 809
Query: 805 LKDKEKSSGTEKNATE---NESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGG 861
D E T+ N + NE++ P P+ P +GE D E + + G
Sbjct: 810 TADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEE-------EPEMPVGP 857
Query: 862 SKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQ 921
+ + E + + + E F ++
Sbjct: 858 RPRPLSELHLKEKA---VPMPEASAFFIFSSNNR-------------------------- 888
Query: 922 NIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFIL 981
R C +IV + F I LLS+ +LA ED IL Y D++FT IF +
Sbjct: 889 -FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILF-YFDIVFTTIFTI 946
Query: 982 EMLLKWMAYG---FKAYFSNGWYR-LDFVVVIVFCLS--LIGKTREELKPLISMKFLRPL 1035
E+ LK AYG K F ++ LD +VV V +S + +K L ++ LRPL
Sbjct: 947 EIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPL 1006
Query: 1036 RVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPT--SG 1093
R +++ + +K VV+ + N+ +V ++ +F+ +GV LF G+ Y C D + +
Sbjct: 1007 RAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTE 1066
Query: 1094 ERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAID 1153
+ + K + WEN+K +FDNV ++L V+TF GW ++ +ID
Sbjct: 1067 AECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSID 1126
Query: 1154 SVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVK 1213
S + P + + + +FI +II F +++ + +I F + G + +
Sbjct: 1127 SHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQ-----GEQEYKNCE 1181
Query: 1214 QRKQYRRLKKLMYEDSQRPVPR--PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMID 1271
K R+ + Y RP+ R P N+ Q ++ VV S F ++ VLI I + +
Sbjct: 1182 LDKNQRQC--VEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1272 TDVQSLQMSIALYWINSIFVMLYTMECILKLIAFR-CFYFTIAWNIFDFMVVIFSITGLC 1330
QS IA+ +N +F L+T+E ILKLIAF+ YF+ WN+FDF++VI SI +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1331 LPMT--VGSYLVPPSL---------VQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPA 1379
L T PS+ + L R++ +++L + L+ + S A
Sbjct: 1300 LSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1359
Query: 1380 LLNIILLIFLVMFIYAVFGMYNFAYV--KKEAGINDVSNFETFGNSMLCLFQVAIFAGWD 1437
L + LLI ++ FIYAV GM F + IN +NF+TF ++L LF+ A W
Sbjct: 1360 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1419
Query: 1438 GMLDAIFNSKWSDCDPDKINPGTQVRGD--CGNPSVGIFYFVSYILISWLIIVNMYIVVV 1495
++ A K C P+ P G+ CG+ S +FYF+S+ ++ +I+N+++ V+
Sbjct: 1420 DIMLACMPGK--KCAPES-EPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVI 1475
Query: 1496 MEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAK-- 1553
M+ + ++ + L +F ++W +DP+ I + + PPL K
Sbjct: 1476 MDNFDYLTRDWS-ILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLC 1534
Query: 1554 PNK---GQLIALDLPM 1566
P++ +L+++++P+
Sbjct: 1535 PHRVACKRLVSMNMPL 1550
Score = 148 bits (373), Expect = 5e-35
Identities = 157/695 (22%), Positives = 284/695 (40%), Gaps = 157/695 (22%)
Query: 95 ASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLL-- 152
AS S N R +++ F IL +L+ + ++ + P N +L
Sbjct: 877 ASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED-PVQHTSFRNHILFY 935
Query: 153 ------GIYTFEILVKLFARGVWAGSFSFLGDPWNWLDF---SVTVFEVIIRYSPLDFIP 203
I+T EI +K+ A G + SF + +N LD SV++ I+ S ++ +
Sbjct: 936 FDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 204 TLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNL 263
L+ R LR L+ I +GLK +V + ++ + ++I+T +F+ IG+ LF G L
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 264 KHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCV 323
+ C ++ E E N YI Y +GE + R
Sbjct: 1056 -YTCSDSSKQTEAECKGN------YIT------YKDGEVDHPIIQPR------------- 1089
Query: 324 KAGINPDQGFTNFDSFGWALFALFRLMA-QDYPEVLYHQI---LYASGKVY------MIF 373
+ + +FD+ A+ ALF + + +PE+LY I G +Y IF
Sbjct: 1090 ----SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1145
Query: 374 FVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKT 433
F++ + +F+M ++F+G + + ++E+ ++ E K
Sbjct: 1146 FIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ--------------------------EYKN 1179
Query: 434 IQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWY--KFAKTFLIWNCSPCW 491
+++ +R + E + K PL Y K + +W
Sbjct: 1180 CELDKNQRQCV--------------------EYALKARPLRRYIPKNQHQYKVW------ 1213
Query: 492 LKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAE 551
++ + + + + + I+LN L ++HY S +NI N++F G+FT E
Sbjct: 1214 --------YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVE 1265
Query: 552 MIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANV-------------------AGM 592
MI K+IA P GYF WN+FD +IV +I++ L+ +
Sbjct: 1266 MILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISI 1325
Query: 593 ALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
RLFR++R+ KL + L+W+ S+ AL + LL+ F A GM++FGK
Sbjct: 1326 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI 1385
Query: 653 YEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVETLWDCM-------------- 697
I+++ + F + L +FR GE W + + CM
Sbjct: 1386 ALNDTTEINRNN-----NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNS 1440
Query: 698 ----EVAGQSWCIPFYLMVILIGNLLVLYLFLALV 728
G S+ + +++ ++ L++ LF+A++
Sbjct: 1441 TEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Score = 71.2 bits (173), Expect = 8e-12
Identities = 86/392 (21%), Positives = 160/392 (40%), Gaps = 89/392 (22%)
Query: 1206 SNIFITVKQRKQYRRLKKLMYEDSQRPVPRPL------NKLQGFIFDVVTSQAFNVIVMV 1259
S + T ++R+QY + KK + RP PR L N ++ +V + F +I+++
Sbjct: 74 STVSSTQRKRQQYGKPKKQGSTTATRP-PRALLCLTLKNPIRRACISIVEWKPFEIIILL 132
Query: 1260 LICFQAIAMMIDT---DVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCF-----YFT 1311
I +A+ I + S + L + +F++++T+E LK+IA+ Y
Sbjct: 133 TIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLR 192
Query: 1312 IAWNIFDFMVVIFSITGLCLPMTV---GSYLVPPSL----VQLILLSRIIHMLRLGKGPK 1364
WN+ DF++V+ + L G+ + V+ + R++ LRL G
Sbjct: 193 NGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVP 252
Query: 1365 VFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF-----AYVKKEAGINDV----- 1414
++ ++ ++ LL+I LL+ V+ IYA+ G+ F + GI DV
Sbjct: 253 SLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDD 312
Query: 1415 -------------------------------SNFETFGNSMLCLFQVAIFAGWDGMLDAI 1443
+NF+ F +ML +FQ GW +L +
Sbjct: 313 PSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 1444 FNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVM-EFLNIA 1502
++ D YFV+ I+I ++N+ + V+ EF
Sbjct: 373 NDAVGRDWP--------------------WIYFVTLIIIGSFFVLNLVLGVLSGEF---- 408
Query: 1503 SKKKNKTLSEDDFRKFFQVWKRFDPDRTQYID 1534
SK++ K + DF+K + ++ + D Y+D
Sbjct: 409 SKEREKAKARGDFQKLREK-QQLEEDLKGYLD 439
>gi|193788544 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 19 [Homo sapiens]
Length = 2135
Score = 407 bits (1045), Expect = e-113
Identities = 399/1576 (25%), Positives = 705/1576 (44%), Gaps = 236/1576 (14%)
Query: 96 SILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSL-------------TNLPK 142
++LC L+ N IRR I ++ F++ IL+++ +CV +++ +NL +
Sbjct: 103 ALLC-LTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLER 161
Query: 143 WRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTV---FEVIIRYSPL 199
+E L I+T E +K+ A G+ ++L + WN LDF + V F I+ +
Sbjct: 162 ----VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK 217
Query: 200 DF-------------IPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLF 246
+ L+ R LR L+++ L+ ++ +I + L+ + +L LF
Sbjct: 218 ADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 277
Query: 247 FLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALL 306
+ I+++IG+ LFMG + C+ N+ G + E
Sbjct: 278 VIIIYAIIGLELFMGKMHKTCY------------NQEG-------------IAAEDDPSP 312
Query: 307 CGNRTDAG-QCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQD-YPEVLYHQILY 364
C T G QC G VC P G TNFD+F +A+ +F+ + + + +VLY +
Sbjct: 313 CALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYW-VND 371
Query: 365 ASGKVY-MIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRV---GEISKKIEPKFQQTGK 420
A G+ + I+FV + + SF++ +L LG+L+ + +E+++ G+ K E QQ +
Sbjct: 372 AVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREK--QQLEE 429
Query: 421 ELQ------------------EGNETDEAKTIQIEMKKRSPISTDTSL--DVL-EDATLR 459
+L+ EG + ++ + + + + ++T+ D+ E+ R
Sbjct: 430 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 489
Query: 460 HKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNV 519
+ KSK F++ + WN C K + V + +I + LN
Sbjct: 490 LAHRISKSK---------FSRYWRRWNRF-CRRKCRAAVKSNVFY----WLVIFLVFLNT 535
Query: 520 CFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFH 579
+ EHY + + N + +FTAEM+ K+ ++ YF +N FD +V
Sbjct: 536 LTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCG 595
Query: 580 GLIELCLANVA-----GMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLL 634
G++E L G+++LR R+LRIFK+ +YW + L+ SL NS ++ L+LLL
Sbjct: 596 GILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLL 655
Query: 635 FTFIFFSAAFGMKLFGK--NYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVE 691
F FI + GM+LFG N++E Q R +F S L VF+IL GE W
Sbjct: 656 FLFIIIFSLLGMQLFGGKFNFDEM--------QTRRSTFDNFPQSLLTVFQILTGEDWNS 707
Query: 692 TLWD-CMEVAGQSW-----CIPFYLMVILIGNLLVLYLFLAL-VSSFSSCKDVTAEENNE 744
++D M G S+ CI +++++ + GN ++L +FLA+ V + + + +T+ + E
Sbjct: 708 VMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 766
Query: 745 AKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDF 804
+ + K L +T + K + V++ + E +
Sbjct: 767 EEEKER--------------KKLARTASPEK------KQELVEKPAVGESKEEKIELKSI 806
Query: 805 LKDKEKSSGTEKNATE---NESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGG 861
D E T+ N + NE++ P P+ P +GE D E + + G
Sbjct: 807 TADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEE-------EPEMPVGP 854
Query: 862 SKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQ 921
+ + E + + + E F ++
Sbjct: 855 RPRPLSELHLKEKA---VPMPEASAFFIFSSNNR-------------------------- 885
Query: 922 NIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFIL 981
R C +IV + F I LLS+ +LA ED IL Y D++FT IF +
Sbjct: 886 -FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILF-YFDIVFTTIFTI 943
Query: 982 EMLLKWMAYG---FKAYFSNGWYR-LDFVVVIVFCLS--LIGKTREELKPLISMKFLRPL 1035
E+ LK AYG K F ++ LD +VV V +S + +K L ++ LRPL
Sbjct: 944 EIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPL 1003
Query: 1036 RVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPT--SG 1093
R +++ + +K VV+ + N+ +V ++ +F+ +GV LF G+ Y C D + +
Sbjct: 1004 RAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTE 1063
Query: 1094 ERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAID 1153
+ + K + WEN+K +FDNV ++L V+TF GW ++ +ID
Sbjct: 1064 AECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSID 1123
Query: 1154 SVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVK 1213
S + P + + + +FI +II F +++ + +I F + G + +
Sbjct: 1124 SHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQ-----GEQEYKNCE 1178
Query: 1214 QRKQYRRLKKLMYEDSQRPVPR--PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMID 1271
K R+ + Y RP+ R P N+ Q ++ VV S F ++ VLI I + +
Sbjct: 1179 LDKNQRQC--VEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1236
Query: 1272 TDVQSLQMSIALYWINSIFVMLYTMECILKLIAFR-CFYFTIAWNIFDFMVVIFSITGLC 1330
QS IA+ +N +F L+T+E ILKLIAF+ YF+ WN+FDF++VI SI +
Sbjct: 1237 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1296
Query: 1331 LPMT--VGSYLVPPSL---------VQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPA 1379
L T PS+ + L R++ +++L + L+ + S A
Sbjct: 1297 LSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1356
Query: 1380 LLNIILLIFLVMFIYAVFGMYNFAYV--KKEAGINDVSNFETFGNSMLCLFQVAIFAGWD 1437
L + LLI ++ FIYAV GM F + IN +NF+TF ++L LF+ A W
Sbjct: 1357 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 1416
Query: 1438 GMLDAIFNSKWSDCDPDKINPGTQVRGD--CGNPSVGIFYFVSYILISWLIIVNMYIVVV 1495
++ A K C P+ P G+ CG+ S +FYF+S+ ++ +I+N+++ V+
Sbjct: 1417 DIMLACMPGK--KCAPES-EPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVI 1472
Query: 1496 MEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAK-- 1553
M+ + ++ + L +F ++W +DP+ I + + PPL K
Sbjct: 1473 MDNFDYLTRDWS-ILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLC 1531
Query: 1554 PNK---GQLIALDLPM 1566
P++ +L+++++P+
Sbjct: 1532 PHRVACKRLVSMNMPL 1547
Score = 148 bits (373), Expect = 5e-35
Identities = 157/695 (22%), Positives = 284/695 (40%), Gaps = 157/695 (22%)
Query: 95 ASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLL-- 152
AS S N R +++ F IL +L+ + ++ + P N +L
Sbjct: 874 ASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED-PVQHTSFRNHILFY 932
Query: 153 ------GIYTFEILVKLFARGVWAGSFSFLGDPWNWLDF---SVTVFEVIIRYSPLDFIP 203
I+T EI +K+ A G + SF + +N LD SV++ I+ S ++ +
Sbjct: 933 FDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 992
Query: 204 TLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNL 263
L+ R LR L+ I +GLK +V + ++ + ++I+T +F+ IG+ LF G L
Sbjct: 993 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1052
Query: 264 KHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCV 323
+ C ++ E E N YI Y +GE + R
Sbjct: 1053 -YTCSDSSKQTEAECKGN------YIT------YKDGEVDHPIIQPR------------- 1086
Query: 324 KAGINPDQGFTNFDSFGWALFALFRLMA-QDYPEVLYHQI---LYASGKVY------MIF 373
+ + +FD+ A+ ALF + + +PE+LY I G +Y IF
Sbjct: 1087 ----SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1142
Query: 374 FVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKT 433
F++ + +F+M ++F+G + + ++E+ ++ E K
Sbjct: 1143 FIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ--------------------------EYKN 1176
Query: 434 IQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWY--KFAKTFLIWNCSPCW 491
+++ +R + E + K PL Y K + +W
Sbjct: 1177 CELDKNQRQCV--------------------EYALKARPLRRYIPKNQHQYKVW------ 1210
Query: 492 LKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAE 551
++ + + + + + I+LN L ++HY S +NI N++F G+FT E
Sbjct: 1211 --------YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVE 1262
Query: 552 MIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANV-------------------AGM 592
MI K+IA P GYF WN+FD +IV +I++ L+ +
Sbjct: 1263 MILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISI 1322
Query: 593 ALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
RLFR++R+ KL + L+W+ S+ AL + LL+ F A GM++FGK
Sbjct: 1323 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI 1382
Query: 653 YEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVETLWDCM-------------- 697
I+++ + F + L +FR GE W + + CM
Sbjct: 1383 ALNDTTEINRNN-----NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNS 1437
Query: 698 ----EVAGQSWCIPFYLMVILIGNLLVLYLFLALV 728
G S+ + +++ ++ L++ LF+A++
Sbjct: 1438 TEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1472
Score = 72.4 bits (176), Expect = 3e-12
Identities = 84/389 (21%), Positives = 160/389 (41%), Gaps = 86/389 (22%)
Query: 1206 SNIFITVKQRKQYRRLKKLMYEDSQRPVPRPL------NKLQGFIFDVVTSQAFNVIVMV 1259
S + T ++R+QY + KK + RP PR L N ++ +V + F +I+++
Sbjct: 74 STVSSTQRKRQQYGKPKKQGSTTATRP-PRALLCLTLKNPIRRACISIVEWKPFEIIILL 132
Query: 1260 LICFQAIAMMIDT---DVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCF-----YFT 1311
I +A+ I + S + L + +F++++T+E LK+IA+ Y
Sbjct: 133 TIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLR 192
Query: 1312 IAWNIFDFMVVIFSITGLCLPMTV---GSYLVPPSL----VQLILLSRIIHMLRLGKGPK 1364
WN+ DF++V+ + L G+ + V+ + R++ LRL G
Sbjct: 193 NGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVP 252
Query: 1365 VFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFG-------MYNFAYVKKEAGIND---- 1413
++ ++ ++ LL+I LL+ V+ IYA+ G M+ Y ++ D
Sbjct: 253 SLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIAAEDDPSP 312
Query: 1414 ---------------------------VSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNS 1446
++NF+ F +ML +FQ GW +L + ++
Sbjct: 313 CALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDA 372
Query: 1447 KWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVM-EFLNIASKK 1505
D YFV+ I+I ++N+ + V+ EF SK+
Sbjct: 373 VGRDWP--------------------WIYFVTLIIIGSFFVLNLVLGVLSGEF----SKE 408
Query: 1506 KNKTLSEDDFRKFFQVWKRFDPDRTQYID 1534
+ K + DF+K + ++ + D Y+D
Sbjct: 409 REKAKARGDFQKLREK-QQLEEDLKGYLD 436
>gi|193794830 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 10 [Homo sapiens]
Length = 2155
Score = 404 bits (1039), Expect = e-112
Identities = 402/1596 (25%), Positives = 710/1596 (44%), Gaps = 256/1596 (16%)
Query: 96 SILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSL-------------TNLPK 142
++LC L+ N IRR I ++ F++ IL+++ +CV +++ +NL +
Sbjct: 103 ALLC-LTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLER 161
Query: 143 WRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTV---FEVIIRYSPL 199
+E L I+T E +K+ A G+ ++L + WN LDF + V F I+ +
Sbjct: 162 ----VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK 217
Query: 200 DF-------------IPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLF 246
+ L+ R LR L+++ L+ ++ +I + L+ + +L LF
Sbjct: 218 ADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 277
Query: 247 FLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALL 306
+ I+++IG+ LFMG + C+ QE + +P
Sbjct: 278 VIIIYAIIGLELFMGKMHKTCYN--QEGIADVPAEDDPSP-------------------- 315
Query: 307 CGNRTDAG-QCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQD-YPEVLYHQILY 364
C T G QC G VC P G TNFD+F +A+ +F+ + + + +VLY +
Sbjct: 316 CALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYW-VND 374
Query: 365 ASGKVY-MIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRV---GEISKKIEPKFQQTGK 420
A G+ + I+FV + + SF++ +L LG+L+ + +E+++ G+ K E QQ +
Sbjct: 375 AVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREK--QQLEE 432
Query: 421 ELQ------------------EGNETDEAKTIQIEMKKRSPISTDTSL--DVL-EDATLR 459
+L+ EG + ++ + + + + ++T+ D+ E+ R
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 460 HKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNV 519
+ KSK F++ + WN C K + V + +I + LN
Sbjct: 493 LAHRISKSK---------FSRYWRRWNRF-CRRKCRAAVKSNVFY----WLVIFLVFLNT 538
Query: 520 CFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFH 579
+ EHY + + N + +FTAEM+ K+ ++ YF +N FD +V
Sbjct: 539 LTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCG 598
Query: 580 GLIELCLANVA-----GMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLL 634
G++E L G+++LR R+LRIFK+ +YW + L+ SL NS ++ L+LLL
Sbjct: 599 GILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLL 658
Query: 635 FTFIFFSAAFGMKLFGK--NYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVE 691
F FI + GM+LFG N++E Q R +F S L VF+IL GE W
Sbjct: 659 FLFIIIFSLLGMQLFGGKFNFDEM--------QTRRSTFDNFPQSLLTVFQILTGEDWNS 710
Query: 692 TLWD-CMEVAGQSW-----CIPFYLMVILIGNLLVLYLFLAL-VSSFSSCKDVTAEENNE 744
++D M G S+ CI +++++ + GN ++L +FLA+ V + + + +T+ + E
Sbjct: 711 VMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769
Query: 745 AKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDF 804
+ + K L +T + K + V++ + E +
Sbjct: 770 EEEKER--------------KKLARTASPEK------KQELVEKPAVGESKEEKIELKSI 809
Query: 805 LKDKEKSSGTEKNATE---NESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGG 861
D E T+ N + NE++ P P+ P +GE D E + + G
Sbjct: 810 TADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEE-------EPEMPVGP 857
Query: 862 SKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQ 921
+ + E + + + E F ++
Sbjct: 858 RPRPLSELHLKEKA---VPMPEASAFFIFSSNNR-------------------------- 888
Query: 922 NIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFIL 981
R C +IV + F I LLS+ +LA ED + +L AD +FT IF L
Sbjct: 889 -FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTL 946
Query: 982 EMLLKWMAYG---FKAYFSNGWYR-LDFVVVIVFCLS--LIGKTREELKPLISMKFLRPL 1035
E++LK AYG K F ++ LD +VV V +S + +K L ++ LRPL
Sbjct: 947 EIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPL 1006
Query: 1036 RVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPT--SG 1093
R +++ + +K VV+ + N+ +V ++ +F+ +GV LF G+ Y C D + +
Sbjct: 1007 RAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTE 1066
Query: 1094 ERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAID 1153
+ + K + WEN+K +FDNV ++L V+TF GW ++ +ID
Sbjct: 1067 AECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSID 1126
Query: 1154 SVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVK 1213
S + P + + + +FI +II F +++ + +I F + G + +
Sbjct: 1127 SHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQ-----GEQEYKNCE 1181
Query: 1214 QRKQYRRLKKLMYEDSQRPVPR--PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMID 1271
K R+ + Y RP+ R P N+ Q ++ VV S F ++ VLI I + +
Sbjct: 1182 LDKNQRQC--VEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1272 TDVQSLQMSIALYWINSIFVMLYTMECILKLIAFR-CFYFTIAWNIFDFMVVIFSITGLC 1330
QS IA+ +N +F L+T+E ILKLIAF+ YF+ WN+FDF++VI SI +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVI 1299
Query: 1331 LPMT----------------VGSYL---------------VPPSLVQLILLSRIIHMLRL 1359
L T VGS + + + +L + R++ +L
Sbjct: 1300 LSETNHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSR 1359
Query: 1360 GKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYV--KKEAGINDVSNF 1417
G+G L+ + S AL + LLI ++ FIYAV GM F + IN +NF
Sbjct: 1360 GEG---IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNF 1416
Query: 1418 ETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGD--CGNPSVGIFY 1475
+TF ++L LF+ A W ++ A K C P+ P G+ CG+ S +FY
Sbjct: 1417 QTFPQAVLLLFRCATGEAWQDIMLACMPGK--KCAPES-EPSNSTEGETPCGS-SFAVFY 1472
Query: 1476 FVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDS 1535
F+S+ ++ +I+N+++ V+M+ + ++ + L +F ++W +DP+ I
Sbjct: 1473 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWS-ILGPHHLDEFKRIWAEYDPEAKGRIKH 1531
Query: 1536 SKLSDFAAALDPPLFMAK--PNK---GQLIALDLPM 1566
+ + PPL K P++ +L+++++P+
Sbjct: 1532 LDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPL 1567
Score = 145 bits (367), Expect = 2e-34
Identities = 158/712 (22%), Positives = 286/712 (40%), Gaps = 174/712 (24%)
Query: 95 ASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG- 153
AS S N R +++ F IL +L+ + ++ + P N +LG
Sbjct: 877 ASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED-PVQHTSFRNHILGN 935
Query: 154 -------IYTFEILVKLFARGVWAGSFSFLGDPWNWLDF---SVTVFEVIIRYSPLDFIP 203
I+T EI++K+ A G + SF + +N LD SV++ I+ S ++ +
Sbjct: 936 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 204 TLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNL 263
L+ R LR L+ I +GLK +V + ++ + ++I+T +F+ IG+ LF G L
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 264 KHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCV 323
+ C ++ E E N YI Y +GE + R
Sbjct: 1056 -YTCSDSSKQTEAECKGN------YIT------YKDGEVDHPIIQPR------------- 1089
Query: 324 KAGINPDQGFTNFDSFGWALFALFRLMA-QDYPEVLYHQI---LYASGKVY------MIF 373
+ + +FD+ A+ ALF + + +PE+LY I G +Y IF
Sbjct: 1090 ----SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1145
Query: 374 FVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKT 433
F++ + +F+M ++F+G + + ++E+ ++ E K
Sbjct: 1146 FIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ--------------------------EYKN 1179
Query: 434 IQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWY--KFAKTFLIWNCSPCW 491
+++ +R + E + K PL Y K + +W
Sbjct: 1180 CELDKNQRQCV--------------------EYALKARPLRRYIPKNQHQYKVW------ 1213
Query: 492 LKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAE 551
++ + + + + + I+LN L ++HY S +NI N++F G+FT E
Sbjct: 1214 --------YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVE 1265
Query: 552 MIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANV---------------------- 589
MI K+IA P GYF WN+FD +IV +I++ L+
Sbjct: 1266 MILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVD 1325
Query: 590 --------------AGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLF 635
+ RLFR++R+ KL + L+W+ S+ AL + LL+
Sbjct: 1326 IAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIV 1385
Query: 636 TFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVETLW 694
F A GM++FGK I+++ + F + L +FR GE W + +
Sbjct: 1386 MLFFIYAVIGMQVFGKIALNDTTEINRNN-----NFQTFPQAVLLLFRCATGEAWQDIML 1440
Query: 695 DCM------------------EVAGQSWCIPFYLMVILIGNLLVLYLFLALV 728
CM G S+ + +++ ++ L++ LF+A++
Sbjct: 1441 ACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1492
Score = 71.2 bits (173), Expect = 8e-12
Identities = 86/392 (21%), Positives = 160/392 (40%), Gaps = 89/392 (22%)
Query: 1206 SNIFITVKQRKQYRRLKKLMYEDSQRPVPRPL------NKLQGFIFDVVTSQAFNVIVMV 1259
S + T ++R+QY + KK + RP PR L N ++ +V + F +I+++
Sbjct: 74 STVSSTQRKRQQYGKPKKQGSTTATRP-PRALLCLTLKNPIRRACISIVEWKPFEIIILL 132
Query: 1260 LICFQAIAMMIDT---DVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCF-----YFT 1311
I +A+ I + S + L + +F++++T+E LK+IA+ Y
Sbjct: 133 TIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLR 192
Query: 1312 IAWNIFDFMVVIFSITGLCLPMTV---GSYLVPPSL----VQLILLSRIIHMLRLGKGPK 1364
WN+ DF++V+ + L G+ + V+ + R++ LRL G
Sbjct: 193 NGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVP 252
Query: 1365 VFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF-----AYVKKEAGINDV----- 1414
++ ++ ++ LL+I LL+ V+ IYA+ G+ F + GI DV
Sbjct: 253 SLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDD 312
Query: 1415 -------------------------------SNFETFGNSMLCLFQVAIFAGWDGMLDAI 1443
+NF+ F +ML +FQ GW +L +
Sbjct: 313 PSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 1444 FNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVM-EFLNIA 1502
++ D YFV+ I+I ++N+ + V+ EF
Sbjct: 373 NDAVGRDWP--------------------WIYFVTLIIIGSFFVLNLVLGVLSGEF---- 408
Query: 1503 SKKKNKTLSEDDFRKFFQVWKRFDPDRTQYID 1534
SK++ K + DF+K + ++ + D Y+D
Sbjct: 409 SKEREKAKARGDFQKLREK-QQLEEDLKGYLD 439
>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 4 [Homo sapiens]
Length = 2173
Score = 404 bits (1037), Expect = e-112
Identities = 398/1579 (25%), Positives = 705/1579 (44%), Gaps = 239/1579 (15%)
Query: 96 SILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSL-------------TNLPK 142
++LC L+ N IRR I ++ F++ IL+++ +CV +++ +NL +
Sbjct: 103 ALLC-LTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLER 161
Query: 143 WRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTV---FEVIIRYSPL 199
+E L I+T E +K+ A G+ ++L + WN LDF + V F I+ +
Sbjct: 162 ----VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATK 217
Query: 200 DF-------------IPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLF 246
+ L+ R LR L+++ L+ ++ +I + L+ + +L LF
Sbjct: 218 ADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLF 277
Query: 247 FLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALL 306
+ I+++IG+ LFMG + C+ QE + +P
Sbjct: 278 VIIIYAIIGLELFMGKMHKTCYN--QEGIADVPAEDDPSP-------------------- 315
Query: 307 CGNRTDAG-QCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQD-YPEVLYHQILY 364
C T G QC G VC P G TNFD+F +A+ +F+ + + + +VLY +
Sbjct: 316 CALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYW-VND 374
Query: 365 ASGKVY-MIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRV---GEISKKIEPKFQQTGK 420
A G+ + I+FV + + SF++ +L LG+L+ + +E+++ G+ K E QQ +
Sbjct: 375 AVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREK--QQLEE 432
Query: 421 ELQ------------------EGNETDEAKTIQIEMKKRSPISTDTSL--DVL-EDATLR 459
+L+ EG + ++ + + + + ++T+ D+ E+ R
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 460 HKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNV 519
+ KSK F++ + WN C K + V + +I + LN
Sbjct: 493 LAHRISKSK---------FSRYWRRWNRF-CRRKCRAAVKSNVFY----WLVIFLVFLNT 538
Query: 520 CFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFH 579
+ EHY + + N + +FTAEM+ K+ ++ YF +N FD +V
Sbjct: 539 LTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCG 598
Query: 580 GLIELCLANVA-----GMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLL 634
G++E L G+++LR R+LRIFK+ +YW + L+ SL NS ++ L+LLL
Sbjct: 599 GILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLL 658
Query: 635 FTFIFFSAAFGMKLFGK--NYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVE 691
F FI + GM+LFG N++E Q R +F S L VF+IL GE W
Sbjct: 659 FLFIIIFSLLGMQLFGGKFNFDEM--------QTRRSTFDNFPQSLLTVFQILTGEDWNS 710
Query: 692 TLWD-CMEVAGQSW-----CIPFYLMVILIGNLLVLYLFLAL-VSSFSSCKDVTAEENNE 744
++D M G S+ CI +++++ + GN ++L +FLA+ V + + + +T+ + E
Sbjct: 711 VMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769
Query: 745 AKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDF 804
+ + K L +T + K + V++ + E +
Sbjct: 770 EEEKER--------------KKLARTASPEK------KQELVEKPAVGESKEEKIELKSI 809
Query: 805 LKDKEKSSGTEKNATE---NESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGG 861
D E T+ N + NE++ P P+ P +GE D E + + G
Sbjct: 810 TADGESPPATKINMDDLQPNENEDKSPYPN-----PETTGEEDEE-------EPEMPVGP 857
Query: 862 SKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQ 921
+ + E + + + E F ++
Sbjct: 858 RPRPLSELHLKEKA---VPMPEASAFFIFSSNNR-------------------------- 888
Query: 922 NIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFIL 981
R C +IV + F I LLS+ +LA ED + +L AD +FT IF L
Sbjct: 889 -FRLQCHRIVNDTIFTNLILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTL 946
Query: 982 EMLLKWMAYG---FKAYFSNGWYR-LDFVVVIVFCLS--LIGKTREELKPLISMKFLRPL 1035
E++LK AYG K F ++ LD +VV V +S + +K L ++ LRPL
Sbjct: 947 EIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPL 1006
Query: 1036 RVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPT--SG 1093
R +++ + +K VV+ + N+ +V ++ +F+ +GV LF G+ Y C D + +
Sbjct: 1007 RAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTE 1066
Query: 1094 ERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAID 1153
+ + K + WEN+K +FDNV ++L V+TF GW ++ +ID
Sbjct: 1067 AECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSID 1126
Query: 1154 SVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVK 1213
S + P + + + +FI +II F +++ + +I F + G + +
Sbjct: 1127 SHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQ-----GEQEYKNCE 1181
Query: 1214 QRKQYRRLKKLMYEDSQRPVPR--PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMID 1271
K R+ + Y RP+ R P N+ Q ++ VV S F ++ VLI I + +
Sbjct: 1182 LDKNQRQC--VEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ 1239
Query: 1272 TDVQSLQMSIALYWINSIFVMLYTMECILKLIAFR-CFYFTIAWNIFDFMVVIFSITGL- 1329
QS IA+ +N +F L+T+E ILKLIAF+ YF AWN FD ++V+ SI +
Sbjct: 1240 HYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIA 1299
Query: 1330 -----------CLPM--TVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLS 1376
C P + + + +L + R++ +L G+G L+ + S
Sbjct: 1300 ITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEG---IRTLLWTFIKS 1356
Query: 1377 LPALLNIILLIFLVMFIYAVFGMYNFAYV--KKEAGINDVSNFETFGNSMLCLFQVAIFA 1434
AL + LLI ++ FIYAV GM F + IN +NF+TF ++L LF+ A
Sbjct: 1357 FQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGE 1416
Query: 1435 GWDGMLDAIFNSKWSDCDPDKINPGTQVRGD--CGNPSVGIFYFVSYILISWLIIVNMYI 1492
W ++ A K C P+ P G+ CG+ S +FYF+S+ ++ +I+N+++
Sbjct: 1417 AWQDIMLACMPGK--KCAPES-EPSNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFV 1472
Query: 1493 VVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMA 1552
V+M+ + ++ + L +F ++W +DP+ I + + PPL
Sbjct: 1473 AVIMDNFDYLTRDWS-ILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFG 1531
Query: 1553 K--PNK---GQLIALDLPM 1566
K P++ +L+++++P+
Sbjct: 1532 KLCPHRVACKRLVSMNMPL 1550
Score = 149 bits (375), Expect = 3e-35
Identities = 156/695 (22%), Positives = 285/695 (41%), Gaps = 157/695 (22%)
Query: 95 ASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG- 153
AS S N R +++ F IL +L+ + ++ + P N +LG
Sbjct: 877 ASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAED-PVQHTSFRNHILGN 935
Query: 154 -------IYTFEILVKLFARGVWAGSFSFLGDPWNWLDF---SVTVFEVIIRYSPLDFIP 203
I+T EI++K+ A G + SF + +N LD SV++ I+ S ++ +
Sbjct: 936 ADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVK 995
Query: 204 TLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNL 263
L+ R LR L+ I +GLK +V + ++ + ++I+T +F+ IG+ LF G L
Sbjct: 996 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 264 KHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCV 323
+ C ++ E E N YI Y +GE + R
Sbjct: 1056 -YTCSDSSKQTEAECKGN------YIT------YKDGEVDHPIIQPR------------- 1089
Query: 324 KAGINPDQGFTNFDSFGWALFALFRLMA-QDYPEVLYHQI---LYASGKVY------MIF 373
+ + +FD+ A+ ALF + + +PE+LY I G +Y IF
Sbjct: 1090 ----SWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1145
Query: 374 FVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKT 433
F++ + +F+M ++F+G + + ++E+ ++ E K
Sbjct: 1146 FIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ--------------------------EYKN 1179
Query: 434 IQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWY--KFAKTFLIWNCSPCW 491
+++ +R + E + K PL Y K + +W
Sbjct: 1180 CELDKNQRQCV--------------------EYALKARPLRRYIPKNQHQYKVW------ 1213
Query: 492 LKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAE 551
++ + + + + + I+LN L ++HY S +NI N++F G+FT E
Sbjct: 1214 --------YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVE 1265
Query: 552 MIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANV-------------------AGM 592
MI K+IA P YF WN FD++IV ++++ + V +
Sbjct: 1266 MILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISI 1325
Query: 593 ALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652
RLFR++R+ KL + L+W+ S+ AL + LL+ F A GM++FGK
Sbjct: 1326 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI 1385
Query: 653 YEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVETLWDCM-------------- 697
I+++ + F + L +FR GE W + + CM
Sbjct: 1386 ALNDTTEINRNN-----NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNS 1440
Query: 698 ----EVAGQSWCIPFYLMVILIGNLLVLYLFLALV 728
G S+ + +++ ++ L++ LF+A++
Sbjct: 1441 TEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Score = 71.2 bits (173), Expect = 8e-12
Identities = 86/392 (21%), Positives = 160/392 (40%), Gaps = 89/392 (22%)
Query: 1206 SNIFITVKQRKQYRRLKKLMYEDSQRPVPRPL------NKLQGFIFDVVTSQAFNVIVMV 1259
S + T ++R+QY + KK + RP PR L N ++ +V + F +I+++
Sbjct: 74 STVSSTQRKRQQYGKPKKQGSTTATRP-PRALLCLTLKNPIRRACISIVEWKPFEIIILL 132
Query: 1260 LICFQAIAMMIDT---DVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCF-----YFT 1311
I +A+ I + S + L + +F++++T+E LK+IA+ Y
Sbjct: 133 TIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLR 192
Query: 1312 IAWNIFDFMVVIFSITGLCLPMTV---GSYLVPPSL----VQLILLSRIIHMLRLGKGPK 1364
WN+ DF++V+ + L G+ + V+ + R++ LRL G
Sbjct: 193 NGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVP 252
Query: 1365 VFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF-----AYVKKEAGINDV----- 1414
++ ++ ++ LL+I LL+ V+ IYA+ G+ F + GI DV
Sbjct: 253 SLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDD 312
Query: 1415 -------------------------------SNFETFGNSMLCLFQVAIFAGWDGMLDAI 1443
+NF+ F +ML +FQ GW +L +
Sbjct: 313 PSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 1444 FNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVM-EFLNIA 1502
++ D YFV+ I+I ++N+ + V+ EF
Sbjct: 373 NDAVGRDWP--------------------WIYFVTLIIIGSFFVLNLVLGVLSGEF---- 408
Query: 1503 SKKKNKTLSEDDFRKFFQVWKRFDPDRTQYID 1534
SK++ K + DF+K + ++ + D Y+D
Sbjct: 409 SKEREKAKARGDFQKLREK-QQLEEDLKGYLD 439
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.327 0.141 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,097,302
Number of Sequences: 37866
Number of extensions: 2570516
Number of successful extensions: 13050
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 98
Number of HSP's successfully gapped in prelim test: 88
Number of HSP's that attempted gapping in prelim test: 9781
Number of HSP's gapped (non-prelim): 1371
length of query: 1682
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1566
effective length of database: 13,855,062
effective search space: 21697027092
effective search space used: 21697027092
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.