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Search of human proteins with 167003331
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor
[Homo sapiens]
(1484 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ... 3028 0.0
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ... 1463 0.0
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr... 1463 0.0
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ... 1383 0.0
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [... 1001 0.0
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ... 938 0.0
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 312 2e-84
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 312 2e-84
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 312 2e-84
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat... 303 8e-82
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate... 258 2e-68
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ... 192 2e-48
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ... 192 2e-48
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p... 191 3e-48
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p... 191 4e-48
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ... 190 1e-47
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p... 190 1e-47
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H... 189 1e-47
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H... 187 6e-47
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H... 187 6e-47
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre... 187 6e-47
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr... 186 1e-46
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ... 181 4e-45
gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p... 179 2e-44
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p... 178 4e-44
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens] 174 6e-43
gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens] 166 1e-40
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens] 166 2e-40
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H... 162 2e-39
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 39 0.037
>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor [Homo
sapiens]
Length = 1484
Score = 3028 bits (7851), Expect = 0.0
Identities = 1484/1484 (100%), Positives = 1484/1484 (100%)
Query: 1 MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFH 60
MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFH
Sbjct: 1 MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFH 60
Query: 61 HLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTL 120
HLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTL
Sbjct: 61 HLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTL 120
Query: 121 TPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQ 180
TPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQ
Sbjct: 121 TPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQ 180
Query: 181 DFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYI 240
DFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYI
Sbjct: 181 DFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYI 240
Query: 241 FEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAII 300
FEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAII
Sbjct: 241 FEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAII 300
Query: 301 TTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHP 360
TTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHP
Sbjct: 301 TTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHP 360
Query: 361 KLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE 420
KLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE
Sbjct: 361 KLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE 420
Query: 421 SVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYL 480
SVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYL
Sbjct: 421 SVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYL 480
Query: 481 VTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSR 540
VTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSR
Sbjct: 481 VTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSR 540
Query: 541 SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSF 600
SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSF
Sbjct: 541 SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSF 600
Query: 601 TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYV 660
TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYV
Sbjct: 601 TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYV 660
Query: 661 DQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLS 720
DQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLS
Sbjct: 661 DQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLS 720
Query: 721 LKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAI 780
LKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAI
Sbjct: 721 LKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAI 780
Query: 781 LQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH 840
LQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH
Sbjct: 781 LQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH 840
Query: 841 LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILR 900
LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILR
Sbjct: 841 LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILR 900
Query: 901 LLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS 960
LLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS
Sbjct: 901 LLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS 960
Query: 961 DYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISK 1020
DYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISK
Sbjct: 961 DYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISK 1020
Query: 1021 KPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKR 1080
KPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKR
Sbjct: 1021 KPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKR 1080
Query: 1081 RKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTK 1140
RKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTK
Sbjct: 1081 RKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTK 1140
Query: 1141 ENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVVSGVPAPWEKN 1200
ENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVVSGVPAPWEKN
Sbjct: 1141 ENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVVSGVPAPWEKN 1200
Query: 1201 LTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSL 1260
LTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSL
Sbjct: 1201 LTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSL 1260
Query: 1261 QELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPR 1320
QELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPR
Sbjct: 1261 QELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPR 1320
Query: 1321 SVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPD 1380
SVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPD
Sbjct: 1321 SVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPD 1380
Query: 1381 RVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPA 1440
RVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPA
Sbjct: 1381 RVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPA 1440
Query: 1441 RFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV 1484
RFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV
Sbjct: 1441 RFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV 1484
>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 1463 bits (3787), Expect = 0.0
Identities = 803/1513 (53%), Positives = 1031/1513 (68%), Gaps = 94/1513 (6%)
Query: 12 FWLVLAVLAVSGSR-----ARSQKSPPSIGIAVILVGTSD--EVAIKDAHEKDDFHHLSV 64
+W +L + A+ R A ++K PP++ IAV+L + D E ++ + L +
Sbjct: 6 YWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPL 65
Query: 65 VPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPIL 124
V + MN TDPKS+IT +CDLMS +I G+VF DDTDQEA+AQ+LDFIS+ T PIL
Sbjct: 66 DVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPIL 125
Query: 125 GIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVN 184
GIHGG+SMIMADKD +S FFQFG SI+QQA+VML IM++YDW++FS+VTT FPGY++F++
Sbjct: 126 GIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFIS 185
Query: 185 KIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVA 244
+++T++NSFVGW+++ V+ LD S +D +K Q QLKK+ S +ILLYC+K+EA I A
Sbjct: 186 FVKTTVDNSFVGWDMQNVITLDTSFED--AKTQVQLKKIHSSVILLYCSKDEAVLILSEA 243
Query: 245 NSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAA 304
S+GLTGY + WIVPSLV+G+T+ +P EFP+GLISVSYD+WDY L ARVRDGI I+TTAA
Sbjct: 244 RSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAA 303
Query: 305 SDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHPKLVI 364
S ML + S+IPE K+SCY E+ + L+ +++NVT++G++LSF+E+GYQ+HP+LV+
Sbjct: 304 SSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPRLVV 363
Query: 365 ILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETE-EQEDDHLSIVTLEEAPFVIVESVD 423
I+LNK+R+WE+VGKW++ +L +++ VWPR ++ E +D+HLSIVTLEEAPFVIVE +D
Sbjct: 364 IVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDID 423
Query: 424 PLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN 483
PL+ TC+RNTVPC+K + N T+E +KKCCKGFCIDILKK+S++VKFTYDLYLVTN
Sbjct: 424 PLTETCVRNTVPCRKFVKINNSTNEGMN-VKKCCKGFCIDILKKLSRTVKFTYDLYLVTN 482
Query: 484 GKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNG 543
GKHGKK+N WNGMIGEVV +RA MAVGSLTINEERSEVVDFSVPF+ETGISVMVSRSNG
Sbjct: 483 GKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNG 542
Query: 544 TVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIG 603
TVSPSAFLEPFSA VWVMMFVMLLIVSA+AVFVFEYFSPVGYNR LA G+ P GPSFTIG
Sbjct: 543 TVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIG 602
Query: 604 KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQV 663
KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE+VDQV
Sbjct: 603 KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQV 662
Query: 664 SGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKT 723
+GLSDKKFQRP+D+SPPFRFGTVPNGSTERNIRNNY MH YM KFNQ+GV+DAL+SLKT
Sbjct: 663 TGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKT 722
Query: 724 GKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQL 783
GKLDAFIYDAAVLNY AGRDEGCKLVTIGSG +FA+TGYGIA+QK S WKRQ+DLA+LQ
Sbjct: 723 GKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQF 782
Query: 784 FGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFY 843
GDGEMEELE LWLTGICHNEKNEVMSSQLDIDNMAGVFYML AAMALSLITFI EHLFY
Sbjct: 783 VGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFY 842
Query: 844 WQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLR 903
W+ R CF GVCS +PG++FSISRGIYSCIHGV IEE++ SP + + SN+L+LLR
Sbjct: 843 WKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKK---KSPDFNLTGSQSNMLKLLR 899
Query: 904 TAKNMANLSGVNG----SPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLF 959
+AKN++++S +N SP+ A DFI+R S + D+ + + +SD +S+ +E++F
Sbjct: 900 SAKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQG---KESIF 956
Query: 960 SDYISEVERTFGNLQLKDSNVYQDHYHH-----HHRPHSIGSASSIDGLYDCDNPPFTTQ 1014
D ++E++ N Q + N Y H P+++ A S + ++
Sbjct: 957 GDNMNELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTES-------KANSR 1009
Query: 1015 SRSISKKPLD-------IGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHT 1067
R + KK +D P S+ + + S KS RY +++ SD+S+ S
Sbjct: 1010 PRQLWKKSVDSIRQDSLSQNPVSQRDEATAENRTHSLKSPRYL-PEEMAHSDISETSNRA 1068
Query: 1068 VTYGNIEGNAAKRRKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKE 1127
+ + + + K + KR ++K ++ E+E Y + SP K Y D E
Sbjct: 1069 TCHREPDNSKNHKTKDNF-----KRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGE 1123
Query: 1128 GLRDFYLDQFRTKENSPHWEHVDLTDIYKERSDDFKR-DSV--SGGGPCTNRSHIKHGTG 1184
F+LD + EN E+VD D Y++ S++F++ DS P N + +
Sbjct: 1124 KEPGFHLDPPQFVENVTLPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSN--N 1181
Query: 1185 DKHGVVSGVPAPWEKNLTNVEWED--RSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRC 1242
D++ + S +K + E + R CRSC S + YS T ++ +C
Sbjct: 1182 DQYKLYSKHFTLKDKGSPHSETSERYRQNSTHCRSCLSNMPTYSGHFT-----MRSPFKC 1236
Query: 1243 EACKKAGNLYDISEDNSLQELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLR--R 1300
+AC + GNLYDI ED LQE PA V Y Q + A + +NKLR R
Sbjct: 1237 DACLRMGNLYDIDEDQMLQETGNPATGEQV--------YQQDWAQNNALQLQKNKLRISR 1288
Query: 1301 QHSYDTFVDLQKE-EAALAPRSVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTA 1359
QHSYD VD +E + + RS+SLKD+ R ++G+ Y +F S S + KSS+
Sbjct: 1289 QHSYDNIVDKPRELDLSRPSRSISLKDRERLLEGNFYGSLF--SVPSSKLSGKKSSLFPQ 1346
Query: 1360 GHHHHNNPGGGYMLSKSLYPDRVTQNPFIPTFGDDQCLLHG---SKSYFFRQPTVA-GAS 1415
G SKSL PD + NPF+ + DDQ L+ G S Y P+ A S
Sbjct: 1347 GLEDSKR-------SKSLLPDHTSDNPFLHSHRDDQRLVIGRCPSDPYKHSLPSQAVNDS 1399
Query: 1416 KARPDFRALVTNKPVVSALHGAVPARFQKDICIGNQSNPCVPNNKN----PRAFNGSSNG 1471
R R+ +A + + +R D+ I P N N PR N SN
Sbjct: 1400 YLRSSLRS--------TASYCSRDSRGHNDVYISEHVMPYAANKNNMYSTPRVLNSCSNR 1451
Query: 1472 HVYEKLSSIESDV 1484
VY+K+ SIESDV
Sbjct: 1452 RVYKKMPSIESDV 1464
>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 1463 bits (3787), Expect = 0.0
Identities = 803/1513 (53%), Positives = 1031/1513 (68%), Gaps = 94/1513 (6%)
Query: 12 FWLVLAVLAVSGSR-----ARSQKSPPSIGIAVILVGTSD--EVAIKDAHEKDDFHHLSV 64
+W +L + A+ R A ++K PP++ IAV+L + D E ++ + L +
Sbjct: 6 YWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPL 65
Query: 65 VPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPIL 124
V + MN TDPKS+IT +CDLMS +I G+VF DDTDQEA+AQ+LDFIS+ T PIL
Sbjct: 66 DVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPIL 125
Query: 125 GIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVN 184
GIHGG+SMIMADKD +S FFQFG SI+QQA+VML IM++YDW++FS+VTT FPGY++F++
Sbjct: 126 GIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFIS 185
Query: 185 KIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVA 244
+++T++NSFVGW+++ V+ LD S +D +K Q QLKK+ S +ILLYC+K+EA I A
Sbjct: 186 FVKTTVDNSFVGWDMQNVITLDTSFED--AKTQVQLKKIHSSVILLYCSKDEAVLILSEA 243
Query: 245 NSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAA 304
S+GLTGY + WIVPSLV+G+T+ +P EFP+GLISVSYD+WDY L ARVRDGI I+TTAA
Sbjct: 244 RSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAA 303
Query: 305 SDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHPKLVI 364
S ML + S+IPE K+SCY E+ + L+ +++NVT++G++LSF+E+GYQ+HP+LV+
Sbjct: 304 SSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPRLVV 363
Query: 365 ILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETE-EQEDDHLSIVTLEEAPFVIVESVD 423
I+LNK+R+WE+VGKW++ +L +++ VWPR ++ E +D+HLSIVTLEEAPFVIVE +D
Sbjct: 364 IVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDID 423
Query: 424 PLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN 483
PL+ TC+RNTVPC+K + N T+E +KKCCKGFCIDILKK+S++VKFTYDLYLVTN
Sbjct: 424 PLTETCVRNTVPCRKFVKINNSTNEGMN-VKKCCKGFCIDILKKLSRTVKFTYDLYLVTN 482
Query: 484 GKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNG 543
GKHGKK+N WNGMIGEVV +RA MAVGSLTINEERSEVVDFSVPF+ETGISVMVSRSNG
Sbjct: 483 GKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNG 542
Query: 544 TVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIG 603
TVSPSAFLEPFSA VWVMMFVMLLIVSA+AVFVFEYFSPVGYNR LA G+ P GPSFTIG
Sbjct: 543 TVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIG 602
Query: 604 KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQV 663
KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE+VDQV
Sbjct: 603 KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQV 662
Query: 664 SGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKT 723
+GLSDKKFQRP+D+SPPFRFGTVPNGSTERNIRNNY MH YM KFNQ+GV+DAL+SLKT
Sbjct: 663 TGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKT 722
Query: 724 GKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQL 783
GKLDAFIYDAAVLNY AGRDEGCKLVTIGSG +FA+TGYGIA+QK S WKRQ+DLA+LQ
Sbjct: 723 GKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQF 782
Query: 784 FGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFY 843
GDGEMEELE LWLTGICHNEKNEVMSSQLDIDNMAGVFYML AAMALSLITFI EHLFY
Sbjct: 783 VGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFY 842
Query: 844 WQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLR 903
W+ R CF GVCS +PG++FSISRGIYSCIHGV IEE++ SP + + SN+L+LLR
Sbjct: 843 WKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKK---KSPDFNLTGSQSNMLKLLR 899
Query: 904 TAKNMANLSGVNG----SPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLF 959
+AKN++++S +N SP+ A DFI+R S + D+ + + +SD +S+ +E++F
Sbjct: 900 SAKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQG---KESIF 956
Query: 960 SDYISEVERTFGNLQLKDSNVYQDHYHH-----HHRPHSIGSASSIDGLYDCDNPPFTTQ 1014
D ++E++ N Q + N Y H P+++ A S + ++
Sbjct: 957 GDNMNELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTES-------KANSR 1009
Query: 1015 SRSISKKPLD-------IGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHT 1067
R + KK +D P S+ + + S KS RY +++ SD+S+ S
Sbjct: 1010 PRQLWKKSVDSIRQDSLSQNPVSQRDEATAENRTHSLKSPRYL-PEEMAHSDISETSNRA 1068
Query: 1068 VTYGNIEGNAAKRRKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKE 1127
+ + + + K + KR ++K ++ E+E Y + SP K Y D E
Sbjct: 1069 TCHREPDNSKNHKTKDNF-----KRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGE 1123
Query: 1128 GLRDFYLDQFRTKENSPHWEHVDLTDIYKERSDDFKR-DSV--SGGGPCTNRSHIKHGTG 1184
F+LD + EN E+VD D Y++ S++F++ DS P N + +
Sbjct: 1124 KEPGFHLDPPQFVENVTLPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSN--N 1181
Query: 1185 DKHGVVSGVPAPWEKNLTNVEWED--RSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRC 1242
D++ + S +K + E + R CRSC S + YS T ++ +C
Sbjct: 1182 DQYKLYSKHFTLKDKGSPHSETSERYRQNSTHCRSCLSNMPTYSGHFT-----MRSPFKC 1236
Query: 1243 EACKKAGNLYDISEDNSLQELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLR--R 1300
+AC + GNLYDI ED LQE PA V Y Q + A + +NKLR R
Sbjct: 1237 DACLRMGNLYDIDEDQMLQETGNPATGEQV--------YQQDWAQNNALQLQKNKLRISR 1288
Query: 1301 QHSYDTFVDLQKE-EAALAPRSVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTA 1359
QHSYD VD +E + + RS+SLKD+ R ++G+ Y +F S S + KSS+
Sbjct: 1289 QHSYDNIVDKPRELDLSRPSRSISLKDRERLLEGNFYGSLF--SVPSSKLSGKKSSLFPQ 1346
Query: 1360 GHHHHNNPGGGYMLSKSLYPDRVTQNPFIPTFGDDQCLLHG---SKSYFFRQPTVA-GAS 1415
G SKSL PD + NPF+ + DDQ L+ G S Y P+ A S
Sbjct: 1347 GLEDSKR-------SKSLLPDHTSDNPFLHSHRDDQRLVIGRCPSDPYKHSLPSQAVNDS 1399
Query: 1416 KARPDFRALVTNKPVVSALHGAVPARFQKDICIGNQSNPCVPNNKN----PRAFNGSSNG 1471
R R+ +A + + +R D+ I P N N PR N SN
Sbjct: 1400 YLRSSLRS--------TASYCSRDSRGHNDVYISEHVMPYAANKNNMYSTPRVLNSCSNR 1451
Query: 1472 HVYEKLSSIESDV 1484
VY+K+ SIESDV
Sbjct: 1452 RVYKKMPSIESDV 1464
>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
precursor [Homo sapiens]
Length = 1281
Score = 1383 bits (3579), Expect = 0.0
Identities = 726/1280 (56%), Positives = 927/1280 (72%), Gaps = 58/1280 (4%)
Query: 12 FWLVLAVLAVSGSR-----ARSQKSPPSIGIAVILVGTSD--EVAIKDAHEKDDFHHLSV 64
+W +L + A+ R A ++K PP++ IAV+L + D E ++ + L +
Sbjct: 6 YWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPL 65
Query: 65 VPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPIL 124
V + MN TDPKS+IT +CDLMS +I G+VF DDTDQEA+AQ+LDFIS+ T PIL
Sbjct: 66 DVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPIL 125
Query: 125 GIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVN 184
GIHGG+SMIMADKD +S FFQFG SI+QQA+VML IM++YDW++FS+VTT FPGY++F++
Sbjct: 126 GIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFIS 185
Query: 185 KIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVA 244
+++T++NSFVGW+++ V+ LD S +D +K Q QLKK+ S +ILLYC+K+EA I A
Sbjct: 186 FVKTTVDNSFVGWDMQNVITLDTSFED--AKTQVQLKKIHSSVILLYCSKDEAVLILSEA 243
Query: 245 NSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAA 304
S+GLTGY + WIVPSLV+G+T+ +P EFP+GLISVSYD+WDY L ARVRDGI I+TTAA
Sbjct: 244 RSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAA 303
Query: 305 SDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHPKLVI 364
S ML + S+IPE K+SCY E+ + L+ +++NVT++G++LSF+E+GYQ+HP+LV+
Sbjct: 304 SSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPRLVV 363
Query: 365 ILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETE-EQEDDHLSIVTLEEAPFVIVESVD 423
I+LNK+R+WE+VGKW++ +L +++ VWPR ++ E +D+HLSIVTLEEAPFVIVE +D
Sbjct: 364 IVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDID 423
Query: 424 PLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN 483
PL+ TC+RNTVPC+K + N T+E +KKCCKGFCIDILKK+S++VKFTYDLYLVTN
Sbjct: 424 PLTETCVRNTVPCRKFVKINNSTNEGMN-VKKCCKGFCIDILKKLSRTVKFTYDLYLVTN 482
Query: 484 GKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNG 543
GKHGKK+N WNGMIGEVV +RA MAVGSLTINEERSEVVDFSVPF+ETGISVMVSRSNG
Sbjct: 483 GKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNG 542
Query: 544 TVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIG 603
TVSPSAFLEPFSA VWVMMFVMLLIVSA+AVFVFEYFSPVGYNR LA G+ P GPSFTIG
Sbjct: 543 TVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIG 602
Query: 604 KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQV 663
KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE+VDQV
Sbjct: 603 KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQV 662
Query: 664 SGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKT 723
+GLSDKKFQRP+D+SPPFRFGTVPNGSTERNIRNNY MH YM KFNQ+GV+DAL+SLKT
Sbjct: 663 TGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKT 722
Query: 724 GKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQL 783
GKLDAFIYDAAVLNY AGRDEGCKLVTIGSG +FA+TGYGIA+QK S WKRQ+DLA+LQ
Sbjct: 723 GKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQF 782
Query: 784 FGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFY 843
GDGEMEELE LWLTGICHNEKNEVMSSQLDIDNMAGVFYML AAMALSLITFI EHLFY
Sbjct: 783 VGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFY 842
Query: 844 WQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLR 903
W+ R CF GVCS +PG++FSISRGIYSCIHGV IEE++ SP + + SN+L+LLR
Sbjct: 843 WKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKK---KSPDFNLTGSQSNMLKLLR 899
Query: 904 TAKNMANLSGVNG----SPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLF 959
+AKN++++S +N SP+ A DFI+R S + D+ + + +SD +S+ +E++F
Sbjct: 900 SAKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQG---KESIF 956
Query: 960 SDYISEVERTFGNLQLKDSNVYQDHYHH-----HHRPHSIGSASSIDGLYDCDNPPFTTQ 1014
D ++E++ N Q + N Y H P+++ A S + ++
Sbjct: 957 GDNMNELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTES-------KANSR 1009
Query: 1015 SRSISKKPLD-------IGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHT 1067
R + KK +D P S+ + + S KS RY +++ SD+S+ S
Sbjct: 1010 PRQLWKKSVDSIRQDSLSQNPVSQRDEATAENRTHSLKSPRYL-PEEMAHSDISETSNRA 1068
Query: 1068 VTYGNIEGNAAKRRKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKE 1127
+ + + + K + KR ++K ++ E+E Y + SP K Y D E
Sbjct: 1069 TCHREPDNSKNHKTKDNF-----KRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGE 1123
Query: 1128 GLRDFYLDQFRTKENSPHWEHVDLTDIYKERSDDFKR-DSV--SGGGPCTNRSHIKHGTG 1184
F+LD + EN E+VD D Y++ S++F++ DS P N + +
Sbjct: 1124 KEPGFHLDPPQFVENVTLPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSN--N 1181
Query: 1185 DKHGVVSGVPAPWEKNLTNVEWED--RSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRC 1242
D++ + S +K + E + R CRSC S + YS T ++ +C
Sbjct: 1182 DQYKLYSKHFTLKDKGSPHSETSERYRQNSTHCRSCLSNMPTYSGHFT-----MRSPFKC 1236
Query: 1243 EACKKAGNLYDISEDNSLQE 1262
+AC + GNLYDI ED LQE
Sbjct: 1237 DACLRMGNLYDIDEDQMLQE 1256
>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
[Homo sapiens]
Length = 1233
Score = 1001 bits (2588), Expect = 0.0
Identities = 490/849 (57%), Positives = 620/849 (73%), Gaps = 5/849 (0%)
Query: 71 VAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGS 130
V +N T+P S++T+IC L+ + G+VF D+ D EA+AQILDFIS+QT PIL I GGS
Sbjct: 67 VGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGS 126
Query: 131 SMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTI 190
++++ K+ S F Q G S+EQQ V+ ++EEYDW F+++T+ PG+ F+ +R+
Sbjct: 127 AVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVA 186
Query: 191 ENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLT 250
+ S V W L +V+ L++ ++ Q L++L +P+ + YC++EEA +F A GL
Sbjct: 187 DASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLV 246
Query: 251 GYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSE 310
G G+ W+VP+L G TD PA FP GLISV + W L +VRDG+AI+ A +
Sbjct: 247 GPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYWRQ 306
Query: 311 HSFIPEPKSSCYNTHEKRIYQSN-MLNRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNK 369
H +P P C H + + R+L+NVT+EGR+ SFS GY + P +V+I LN+
Sbjct: 307 HGTLPAPAGDC-RVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALNR 365
Query: 370 ERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDD-HLSIVTLEEAPFVIVESVDPLSGT 428
R WE VG+W+ L MKY VWPR + D HL++ TLEE PFVIVES DP +G
Sbjct: 366 HRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPDPGTGG 425
Query: 429 CMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGK 488
C+ NTVPC+++ + + Y K CCKGFCIDILKK+++ VKF+YDLYLVTNGKHGK
Sbjct: 426 CVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGK 485
Query: 489 KINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPS 548
++ G WNGMIGEV KRA MA+GSLTINEERSE+VDFSVPF+ETGISVMV+RSNGTVSPS
Sbjct: 486 RVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS 545
Query: 549 AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWL 608
AFLEP+S VWVMMFVM L V A+ VF+FEYFSPV YN+ L G++ GGP+FTIGK++WL
Sbjct: 546 AFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWL 605
Query: 609 LWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSD 668
LW LVFNNSVP++NP+GTTSKIMV VWAFFAVIFLASYTANLAAFMIQE+Y+D VSGLSD
Sbjct: 606 LWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSD 665
Query: 669 KKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKLDA 728
KKFQRP D PPFRFGTVPNGSTERNIR+NY +MH +M KFNQR V+DAL SLK GKLDA
Sbjct: 666 KKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGKLDA 725
Query: 729 FIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGE 788
FIYDAAVLNYMAG+DEGCKLVTIGSGKVFA+TGYGIA+QKDS WKR +DLA+LQ GDGE
Sbjct: 726 FIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGE 785
Query: 789 MEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFRH 848
++LE +WL+GIC NEKNEVMSS+LDIDNMAGVFYML AM L+L+ F EHL YW+ RH
Sbjct: 786 TQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRH 845
Query: 849 CFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNM 908
S + + + SRGIYSC GV SP T ++ +++L++L+ A++M
Sbjct: 846 SVPN--SSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAARDM 903
Query: 909 ANLSGVNGS 917
+GV+ S
Sbjct: 904 VTTAGVSSS 912
>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor
[Homo sapiens]
Length = 1336
Score = 938 bits (2425), Expect = 0.0
Identities = 463/814 (56%), Positives = 594/814 (72%), Gaps = 19/814 (2%)
Query: 71 VAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGS 130
+ +N +DP+S++ ++CDL+S ++ GVVF DD+ A+A ILDF+SAQT PI+ +HGG+
Sbjct: 89 LVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGA 148
Query: 131 SMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTI 190
++++ K++ S F Q G S EQQ V+ ++EEYDW F VTT PG++ F++ I
Sbjct: 149 ALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLT 208
Query: 191 ENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLT 250
+ S VGWE L LD G++ + QL+ + + I LL+C +EEA +F A GLT
Sbjct: 209 DGSLVGWEHRGALTLDPGA--GEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLT 266
Query: 251 GYGYTWIV--PSLVAGDTDTVPAE---------FPTGLISVSYDEWDYGLPARVRDGIAI 299
G GY W + P L G P E P GL +V W L RV G+A+
Sbjct: 267 GSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAV 326
Query: 300 ITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMH 359
+ A +L ++ F+PE C + R ++ L+RY +N+T++ R+ SF+EDG+ ++
Sbjct: 327 VARGAQALLRDYGFLPELGHDC--RAQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVN 384
Query: 360 PKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQED-DHLSIVTLEEAPFVI 418
P LV+I L ++R WE VG W+ ++L++KY +W R + +D HL++ TLEE PFVI
Sbjct: 385 PSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVI 444
Query: 419 VESVDPLSGTCMRNTVPCQKRIV-TENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYD 477
VE DP+SGTC+R++VPC+ ++ T + + P K+CCKGFCIDILK+++ ++ F+YD
Sbjct: 445 VEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYD 504
Query: 478 LYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVM 537
LYLVTNGKHGKKI+G WNGMIGEV +RA MA+GSLTINEERSE+VDFSVPF+ETGISVM
Sbjct: 505 LYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVM 564
Query: 538 VSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGG 597
V+RSNGTVSPSAFLEP+S VWVMMFVM L V AV VF+FEY SPVGYNR LA G+ PGG
Sbjct: 565 VARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGG 624
Query: 598 PSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQE 657
+FTIGK+IWLLW LVFNNSVPV+NP+GTTSKIMV VWAFFAVIFLASYTANLAAFMIQE
Sbjct: 625 STFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQE 684
Query: 658 EYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDA 717
EYVD VSGLSD+KFQRP + PP +FGTVPNGSTE+NIR+NY +MH+YM ++NQ V++A
Sbjct: 685 EYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEA 744
Query: 718 LLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVD 777
L LK GKLDAFIYDAAVLNYMA +DEGCKLVTIGSGKVFA+TGYGIA+ K S WKR +D
Sbjct: 745 LTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPID 804
Query: 778 LAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFI 837
LA+LQ GD E+E LE LWL+GICHN+K EVMSS+LDIDNMAGVFYML AM LSL+ F
Sbjct: 805 LALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFA 864
Query: 838 CEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSC 871
EHL YW+ RHC + + + + SRG+YSC
Sbjct: 865 WEHLVYWRLRHCLGP--THRMDFLLAFSRGMYSC 896
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 312 bits (799), Expect = 2e-84
Identities = 244/863 (28%), Positives = 440/863 (50%), Gaps = 71/863 (8%)
Query: 14 LVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELVAM 73
L+ L S S AR+ P + I +L E ++A + + H S +++L A
Sbjct: 6 LLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSW--KIQLNAT 63
Query: 74 NETDPKSIITR---IC-DLMSDRKIQGVVFADDTDQEAIAQI-LDFISAQTLTPILGIHG 128
+ T + I +C DL+S + +V T + + + + P+LG+
Sbjct: 64 SVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTT 123
Query: 129 GSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDW-YIFSIVTTYFPGYQDFVNKIR 187
S I +DK F + P Q+SV +M Y W +I +V+ G + ++
Sbjct: 124 RMS-IYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG-RAAQKRLE 181
Query: 188 STIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSV 247
+ +E + E+VL D + + + + K+L++ +I+L ++++A ++ A +
Sbjct: 182 TLLEERES--KAEKVLQFDPGTKNVTALLM-EAKELEARVIILSASEDDAATVYRAAAML 238
Query: 248 GLTGYGYTWIVPSL-VAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASD 306
+TG GY W+V ++G+ + GL ++ A + D + ++ A +
Sbjct: 239 NMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNES----AHISDAVGVVAQAVHE 294
Query: 307 MLSEHSFIPEPKSSCYNTHE-------KRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMH 359
+L + + P+ NT+ KR+ S+ +Y VT GR + F+EDG +
Sbjct: 295 LLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSS---KYADGVT--GR-VEFNEDGDRKF 348
Query: 360 PKLVIILLNKERKWERVGKWKDKSL--QMKYYVWPRMCPETEE----QEDDHLSIVTLEE 413
I+ L + RK +VG + + + +WP ETE+ Q L IVT+ +
Sbjct: 349 ANYSIMNL-QNRKLVQVGIYNGTHVIPNDRKIIWPG--GETEKPRGYQMSTRLKIVTIHQ 405
Query: 414 APFVIVESVDPLSGTCMR----NTVPCQKRIVTENKTDEEPGY----IKKCCKGFCIDIL 465
PFV V+ GTC N P +K I T D PG + +CC GFCID+L
Sbjct: 406 EPFVYVKPTLS-DGTCKEEFTVNGDPVKKVICT-GPNDTSPGSPRHTVPQCCYGFCIDLL 463
Query: 466 KKISKSVKFTYDLYLVTNGKHG--KKINGT----WNGMIGEVVMKRAYMAVGSLTINEER 519
K+++++ FTY+++LV +GK G +++N + WNGM+GE++ +A M V LTIN ER
Sbjct: 464 IKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNER 523
Query: 520 SEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEY 579
++ ++FS PF G++++V + + +F++PF + +W+++ + + +V AV +++ +
Sbjct: 524 AQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVV-AVMLYLLDR 582
Query: 580 FSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFA 639
FSP G R + E + T+ A+W WG++ N+ + P+ +++I+ VWA FA
Sbjct: 583 FSPFG--RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFA 640
Query: 640 VIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRN-- 697
+I +ASYTANLAAF++ + ++++G++D + + P+D F + TV S + R
Sbjct: 641 MIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSD---KFIYATVKQSSVDIYFRRQV 697
Query: 698 NYAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVF 757
+ M+ +M K N +A+ +++ KL AFI+D+AVL + A + C LVT +G++F
Sbjct: 698 ELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELF 753
Query: 758 ASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLT-GICHNEKNEVMSSQLDID 816
+G+GI ++KDS WK+ V L+IL+ +G ME+L+ W+ C + N + L +
Sbjct: 754 FRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APATLTFE 811
Query: 817 NMAGVFYMLGAAMALSLITFICE 839
NMAGVF ++ + + E
Sbjct: 812 NMAGVFMLVAGGIVAGIFLIFIE 834
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 312 bits (799), Expect = 2e-84
Identities = 244/863 (28%), Positives = 440/863 (50%), Gaps = 71/863 (8%)
Query: 14 LVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELVAM 73
L+ L S S AR+ P + I +L E ++A + + H S +++L A
Sbjct: 6 LLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSW--KIQLNAT 63
Query: 74 NETDPKSIITR---IC-DLMSDRKIQGVVFADDTDQEAIAQI-LDFISAQTLTPILGIHG 128
+ T + I +C DL+S + +V T + + + + P+LG+
Sbjct: 64 SVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTT 123
Query: 129 GSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDW-YIFSIVTTYFPGYQDFVNKIR 187
S I +DK F + P Q+SV +M Y W +I +V+ G + ++
Sbjct: 124 RMS-IYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG-RAAQKRLE 181
Query: 188 STIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSV 247
+ +E + E+VL D + + + + K+L++ +I+L ++++A ++ A +
Sbjct: 182 TLLEERES--KAEKVLQFDPGTKNVTALLM-EAKELEARVIILSASEDDAATVYRAAAML 238
Query: 248 GLTGYGYTWIVPSL-VAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASD 306
+TG GY W+V ++G+ + GL ++ A + D + ++ A +
Sbjct: 239 NMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNES----AHISDAVGVVAQAVHE 294
Query: 307 MLSEHSFIPEPKSSCYNTHE-------KRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMH 359
+L + + P+ NT+ KR+ S+ +Y VT GR + F+EDG +
Sbjct: 295 LLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSS---KYADGVT--GR-VEFNEDGDRKF 348
Query: 360 PKLVIILLNKERKWERVGKWKDKSL--QMKYYVWPRMCPETEE----QEDDHLSIVTLEE 413
I+ L + RK +VG + + + +WP ETE+ Q L IVT+ +
Sbjct: 349 ANYSIMNL-QNRKLVQVGIYNGTHVIPNDRKIIWPG--GETEKPRGYQMSTRLKIVTIHQ 405
Query: 414 APFVIVESVDPLSGTCMR----NTVPCQKRIVTENKTDEEPGY----IKKCCKGFCIDIL 465
PFV V+ GTC N P +K I T D PG + +CC GFCID+L
Sbjct: 406 EPFVYVKPTLS-DGTCKEEFTVNGDPVKKVICT-GPNDTSPGSPRHTVPQCCYGFCIDLL 463
Query: 466 KKISKSVKFTYDLYLVTNGKHG--KKINGT----WNGMIGEVVMKRAYMAVGSLTINEER 519
K+++++ FTY+++LV +GK G +++N + WNGM+GE++ +A M V LTIN ER
Sbjct: 464 IKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNER 523
Query: 520 SEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEY 579
++ ++FS PF G++++V + + +F++PF + +W+++ + + +V AV +++ +
Sbjct: 524 AQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVV-AVMLYLLDR 582
Query: 580 FSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFA 639
FSP G R + E + T+ A+W WG++ N+ + P+ +++I+ VWA FA
Sbjct: 583 FSPFG--RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFA 640
Query: 640 VIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRN-- 697
+I +ASYTANLAAF++ + ++++G++D + + P+D F + TV S + R
Sbjct: 641 MIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSD---KFIYATVKQSSVDIYFRRQV 697
Query: 698 NYAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVF 757
+ M+ +M K N +A+ +++ KL AFI+D+AVL + A + C LVT +G++F
Sbjct: 698 ELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELF 753
Query: 758 ASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLT-GICHNEKNEVMSSQLDID 816
+G+GI ++KDS WK+ V L+IL+ +G ME+L+ W+ C + N + L +
Sbjct: 754 FRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APATLTFE 811
Query: 817 NMAGVFYMLGAAMALSLITFICE 839
NMAGVF ++ + + E
Sbjct: 812 NMAGVFMLVAGGIVAGIFLIFIE 834
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 312 bits (799), Expect = 2e-84
Identities = 244/863 (28%), Positives = 440/863 (50%), Gaps = 71/863 (8%)
Query: 14 LVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELVAM 73
L+ L S S AR+ P + I +L E ++A + + H S +++L A
Sbjct: 6 LLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSW--KIQLNAT 63
Query: 74 NETDPKSIITR---IC-DLMSDRKIQGVVFADDTDQEAIAQI-LDFISAQTLTPILGIHG 128
+ T + I +C DL+S + +V T + + + + P+LG+
Sbjct: 64 SVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTT 123
Query: 129 GSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDW-YIFSIVTTYFPGYQDFVNKIR 187
S I +DK F + P Q+SV +M Y W +I +V+ G + ++
Sbjct: 124 RMS-IYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG-RAAQKRLE 181
Query: 188 STIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSV 247
+ +E + E+VL D + + + + K+L++ +I+L ++++A ++ A +
Sbjct: 182 TLLEERES--KAEKVLQFDPGTKNVTALLM-EAKELEARVIILSASEDDAATVYRAAAML 238
Query: 248 GLTGYGYTWIVPSL-VAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASD 306
+TG GY W+V ++G+ + GL ++ A + D + ++ A +
Sbjct: 239 NMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNES----AHISDAVGVVAQAVHE 294
Query: 307 MLSEHSFIPEPKSSCYNTHE-------KRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMH 359
+L + + P+ NT+ KR+ S+ +Y VT GR + F+EDG +
Sbjct: 295 LLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSS---KYADGVT--GR-VEFNEDGDRKF 348
Query: 360 PKLVIILLNKERKWERVGKWKDKSL--QMKYYVWPRMCPETEE----QEDDHLSIVTLEE 413
I+ L + RK +VG + + + +WP ETE+ Q L IVT+ +
Sbjct: 349 ANYSIMNL-QNRKLVQVGIYNGTHVIPNDRKIIWPG--GETEKPRGYQMSTRLKIVTIHQ 405
Query: 414 APFVIVESVDPLSGTCMR----NTVPCQKRIVTENKTDEEPGY----IKKCCKGFCIDIL 465
PFV V+ GTC N P +K I T D PG + +CC GFCID+L
Sbjct: 406 EPFVYVKPTLS-DGTCKEEFTVNGDPVKKVICT-GPNDTSPGSPRHTVPQCCYGFCIDLL 463
Query: 466 KKISKSVKFTYDLYLVTNGKHG--KKINGT----WNGMIGEVVMKRAYMAVGSLTINEER 519
K+++++ FTY+++LV +GK G +++N + WNGM+GE++ +A M V LTIN ER
Sbjct: 464 IKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNER 523
Query: 520 SEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEY 579
++ ++FS PF G++++V + + +F++PF + +W+++ + + +V AV +++ +
Sbjct: 524 AQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVV-AVMLYLLDR 582
Query: 580 FSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFA 639
FSP G R + E + T+ A+W WG++ N+ + P+ +++I+ VWA FA
Sbjct: 583 FSPFG--RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFA 640
Query: 640 VIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRN-- 697
+I +ASYTANLAAF++ + ++++G++D + + P+D F + TV S + R
Sbjct: 641 MIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSD---KFIYATVKQSSVDIYFRRQV 697
Query: 698 NYAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVF 757
+ M+ +M K N +A+ +++ KL AFI+D+AVL + A + C LVT +G++F
Sbjct: 698 ELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELF 753
Query: 758 ASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLT-GICHNEKNEVMSSQLDID 816
+G+GI ++KDS WK+ V L+IL+ +G ME+L+ W+ C + N + L +
Sbjct: 754 FRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APATLTFE 811
Query: 817 NMAGVFYMLGAAMALSLITFICE 839
NMAGVF ++ + + E
Sbjct: 812 NMAGVFMLVAGGIVAGIFLIFIE 834
>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
[Homo sapiens]
Length = 1115
Score = 303 bits (776), Expect = 8e-82
Identities = 248/885 (28%), Positives = 416/885 (47%), Gaps = 81/885 (9%)
Query: 76 TDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMA 135
+DP S + +C + + + ++ + E + LD +S P++ I
Sbjct: 175 SDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMME--LDLVSLVLHIPVISIVRHE---FP 229
Query: 136 DKDESSMFFQFG--PSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENS 193
+ ++ + Q S+ A V ++I+ +WY FS++ + + + T NS
Sbjct: 230 RESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDW--NITDFLLLTQNNS 287
Query: 194 FVGWELEEVLLLDMSL---DDGDSKIQNQLKKLQSP---IILLYCTKEEATYIFEVANSV 247
+ L ++ + +L D S +Q QL+ +++ +++ C E IFE+
Sbjct: 288 --KFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQF 345
Query: 248 GLTGYGYTWIVPSLVAGDTDTVPA----EFPTGLISVSYDEWDYGLPARVRDGIAIITTA 303
G+ W++ GD+ V P GLI+ V+D + ++ A
Sbjct: 346 GVMPPELRWVL-----GDSQNVEELRTEGLPLGLIAHGKTTQSV-FEHYVQDAMELVARA 399
Query: 304 ---ASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQM-H 359
A+ + E + IP + C + L+R+L N TF G + S G +
Sbjct: 400 VATATMIQPELALIPSTMN-CMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVS 458
Query: 360 PKLVIILLNKERK------WERVGKWKDKSLQMKYYVWPRMCP--ETEEQEDD--HLSIV 409
+ + N + W R+G W+ + M Y +WP +T Q HL +V
Sbjct: 459 SENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVV 518
Query: 410 TLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKT------------DEEPGYIKKCC 457
TL E PFV VD G C + C + ++ T D P KKCC
Sbjct: 519 TLIEHPFVFTREVDD-EGLCPAGQL-CLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCC 576
Query: 458 KGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINE 517
G+CID+L+KI++ + F +DLY+V +GK+G NG W G++G+++ A+MAV S +IN
Sbjct: 577 YGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINT 636
Query: 518 ERSEVVDFSVPFIETGISVMVSRSNGTVSP-SAFLEPFSADVWVMMFVMLLIVSAVAVFV 576
RS+V+DF+ PF T + ++V R+ T +P AF+ P +W+ +FV L I +AV + +
Sbjct: 637 ARSQVIDFTSPFFSTSLGILV-RTRDTAAPIGAFMWPLHWTMWLGIFVALHI-TAVFLTL 694
Query: 577 FEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWA 636
+E+ SP G L F+ A+ + + L+F +V ++ PK T + ++++WA
Sbjct: 695 YEWKSPFG----LTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWA 750
Query: 637 FFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIR 696
F + L++YTANLAA M+ E+ +++SG+ D K P S FRFGTV S E +R
Sbjct: 751 IFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHP---SQGFRFGTVRESSAEDYVR 807
Query: 697 NNYAEMHAYMGKFNQRGVDDALLSLKTG--KLDAFIYDAAVLNYMAGRDEGCKLVTIGSG 754
++ EMH YM ++N D + LK KLDAFI D A+L+Y D CKL+T+ G
Sbjct: 808 QSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTV--G 865
Query: 755 KVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSS--Q 812
K FA GYGI + +S + I Q G M+ L W + +++ ++ Q
Sbjct: 866 KPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQ 925
Query: 813 LDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSI--SRGIYS 870
+ I + +G+F +L LS++T I EH+ Y + K + + + S+ ++
Sbjct: 926 MGIKHFSGLFVLLCIGFGLSILTTIGEHIVY----RLLLPRIKNKSKLQYWLHTSQRLHR 981
Query: 871 CIHGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNMANLSGVN 915
I+ IEE+Q + SN+ T N +NLS N
Sbjct: 982 AINTSFIEEKQQHFKTKRV---EKRSNVGPRQLTVWNTSNLSHDN 1023
>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
[Homo sapiens]
Length = 1043
Score = 258 bits (660), Expect = 2e-68
Identities = 222/823 (26%), Positives = 388/823 (47%), Gaps = 73/823 (8%)
Query: 60 HHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQT 119
H+LS+ + + A DP S+ +C + + ++ + E + L F++A T
Sbjct: 68 HNLSL--ELVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELLQ--LHFLAAAT 123
Query: 120 LTPILGIHGGSSMI-MADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYI--FSIVTTYF 176
TP+L + + + + + + +E V++ +++ + W ++ T
Sbjct: 124 ETPVLSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCRTQD 183
Query: 177 PGYQDFVNKIRSTIENSFVGWELEEVLLLDMSL-DDGDSKIQNQLKKLQSPI-------- 227
PG + S G + L+LD+S D GD+ ++ +L + +P+
Sbjct: 184 PGGL-------VALWTSRAGRPPQ--LVLDLSRRDTGDAGLRARLAPMAAPVGGEAPVPA 234
Query: 228 -ILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWD 286
+LL C A + E G W++ + + A P GL+++ +
Sbjct: 235 AVLLGCDIARARRVLEAVPP------GPHWLLGTPLPPKA-LPTAGLPPGLLALG-EVAR 286
Query: 287 YGLPARVRDGIAIITTA---ASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVT 343
L A + D + ++ A A+ + + + +P P + L R+L N +
Sbjct: 287 PPLEAAIHDIVQLVARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLARFLANTS 346
Query: 344 FEGRNLSFSEDGY-QMHPKLVIILLNKERK------WERVGKWKDKSLQMKYY-VWPRMC 395
F+GR G Q+H + + R W VG W+D L ++ R
Sbjct: 347 FQGRTGPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPP 406
Query: 396 PETEEQEDDHLSIVTLEEAPFVIVESVD-----PLSGTCM---RNTVPCQKRIVTENKTD 447
P Q L +VTL E PFV D P C+ N +
Sbjct: 407 PPQGAQVWPKLRVVTLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDALFAALANG 466
Query: 448 EEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAY 507
P ++KCC G+CID+L+++++ F ++LYLV +GK+G +G W G++G+++ RA+
Sbjct: 467 SAPRALRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALRDGRWTGLVGDLLAGRAH 526
Query: 508 MAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSP-SAFLEPFSADVWVMMFVML 566
MAV S +IN RS+VVDF+ PF T + +MV R+ T SP AF+ P W+ +F L
Sbjct: 527 MAVTSFSINSARSQVVDFTSPFFSTSLGIMV-RARDTASPIGAFMWPLHWSTWLGVFAAL 585
Query: 567 LIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGT 626
+ +A+ + V+E+ SP G L F+ A+ L + ++F +V + PK
Sbjct: 586 HL-TALFLTVYEWRSPYG----LTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCP 640
Query: 627 TSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTV 686
T ++++++WA F ++ L+SYTANLAA M+ ++ +++SG+ D K P + FRFGTV
Sbjct: 641 TGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHP---AQGFRFGTV 697
Query: 687 PNGSTERNIRNNYAEMHAYMGKFN----QRGVDDALLSLKTGKLDAFIYDAAVLNYMAGR 742
S E I+ ++ +MHA+M + + RGV A+L+ KL+AFI D ++L+Y
Sbjct: 698 WESSAEAYIKKSFPDMHAHMRRHSAPTTPRGV--AMLTSDPPKLNAFIMDKSLLDYEVSI 755
Query: 743 DEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGI-C 801
D CKL+T+ GK FA GYGI + ++S + I + G ++ L W + C
Sbjct: 756 DADCKLLTV--GKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPC 813
Query: 802 HNEKNEVMSS-QLDIDNMAGVFYMLGAAMALSLITFICEHLFY 843
V + Q+ I + AG+F +L + +L++ + EH F+
Sbjct: 814 GKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFF 856
>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
precursor [Homo sapiens]
Length = 908
Score = 192 bits (488), Expect = 2e-48
Identities = 138/478 (28%), Positives = 239/478 (50%), Gaps = 57/478 (11%)
Query: 403 DDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTEN------------------ 444
D L +++L+E + + DP SG M + + +T++
Sbjct: 386 DFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVL 445
Query: 445 -KTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKK--INGTWNGMIGEV 501
K ++P Y +G+CID+L+++S + FTY++ LV +GK+G + NG WNGM+ E+
Sbjct: 446 FKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVREL 505
Query: 502 VMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPS--AFLEPFSADVW 559
+ +A +AV L I R +V+DFS PF+ GIS++ + NGT +P +FL P S D+W
Sbjct: 506 IDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGT-NPGVFSFLNPLSPDIW 564
Query: 560 VMMFVMLLIVSAVAVFVFEYFSPVGY---NRCLADGREPGGPSFTIGKAIWLLWGLVFNN 616
+ + + L VS V +FV FSP + + C D + +FT+ + W G +
Sbjct: 565 MYILLAYLGVSCV-LFVIARFSPYEWYNPHPCNPDS-DVVENNFTLLNSFWFGVGALMQQ 622
Query: 617 SVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPND 676
+ PK +++I+ +W FF +I ++SYTANLAAF+ E + D Q
Sbjct: 623 GSELM-PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ---- 677
Query: 677 FSPPFRFGTVPNGST----ERNIRNNYAEMHAYMG--------KFNQRGVDDALLSLKTG 724
+G V +G+T +++ + Y +M A+M K N+ G+ L S
Sbjct: 678 --TKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY-- 733
Query: 725 KLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLF 784
AF+ ++ + ++ R+ C L IG + S GYG+ S ++ ++ +AILQL
Sbjct: 734 ---AFLMESTTIEFVTQRN--CNLTQIGG--LIDSKGYGVGTPMGSPYRDKITIAILQLQ 786
Query: 785 GDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLF 842
+G++ ++ W G E+ +S L + N+ G+F +L A + LS+ + E L+
Sbjct: 787 EEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLY 844
>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
precursor [Homo sapiens]
Length = 869
Score = 192 bits (488), Expect = 2e-48
Identities = 138/478 (28%), Positives = 239/478 (50%), Gaps = 57/478 (11%)
Query: 403 DDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTEN------------------ 444
D L +++L+E + + DP SG M + + +T++
Sbjct: 386 DFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVL 445
Query: 445 -KTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKK--INGTWNGMIGEV 501
K ++P Y +G+CID+L+++S + FTY++ LV +GK+G + NG WNGM+ E+
Sbjct: 446 FKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVREL 505
Query: 502 VMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPS--AFLEPFSADVW 559
+ +A +AV L I R +V+DFS PF+ GIS++ + NGT +P +FL P S D+W
Sbjct: 506 IDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGT-NPGVFSFLNPLSPDIW 564
Query: 560 VMMFVMLLIVSAVAVFVFEYFSPVGY---NRCLADGREPGGPSFTIGKAIWLLWGLVFNN 616
+ + + L VS V +FV FSP + + C D + +FT+ + W G +
Sbjct: 565 MYILLAYLGVSCV-LFVIARFSPYEWYNPHPCNPDS-DVVENNFTLLNSFWFGVGALMQQ 622
Query: 617 SVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPND 676
+ PK +++I+ +W FF +I ++SYTANLAAF+ E + D Q
Sbjct: 623 GSELM-PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ---- 677
Query: 677 FSPPFRFGTVPNGST----ERNIRNNYAEMHAYMG--------KFNQRGVDDALLSLKTG 724
+G V +G+T +++ + Y +M A+M K N+ G+ L S
Sbjct: 678 --TKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY-- 733
Query: 725 KLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLF 784
AF+ ++ + ++ R+ C L IG + S GYG+ S ++ ++ +AILQL
Sbjct: 734 ---AFLMESTTIEFVTQRN--CNLTQIGG--LIDSKGYGVGTPMGSPYRDKITIAILQLQ 786
Query: 785 GDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLF 842
+G++ ++ W G E+ +S L + N+ G+F +L A + LS+ + E L+
Sbjct: 787 EEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLY 844
>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
precursor [Homo sapiens]
Length = 902
Score = 191 bits (486), Expect = 3e-48
Identities = 197/794 (24%), Positives = 337/794 (42%), Gaps = 117/794 (14%)
Query: 104 DQEAIAQILDFISA---QTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNI 160
D+ ++ + F SA +TP G ES Q PS+ +L++
Sbjct: 99 DKRSVHTLTSFCSALHISLITPSFPTEG----------ESQFVLQLRPSLR---GALLSL 145
Query: 161 MEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQL 220
++ Y+W F + GY + +N GW + + + + + D ++ +L
Sbjct: 146 LDHYEWNCFVFLYDTDRGYSILQAIMEKAGQN---GWHVSAICVENFN-DVSYRQLLEEL 201
Query: 221 KKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGD-------------TD 267
+ Q ++ C E I E SVG GY +I+ +L D T
Sbjct: 202 DRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTG 261
Query: 268 TVPAEFPTGLISVSYDEW------DYG--------LPARVRDGIAIITTAASDMLSEHSF 313
+F T ++ D W +Y A DG+ ++ + +
Sbjct: 262 FQLVDFNTPMVIKLMDRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKID 321
Query: 314 IPEPKSS--CYNTHEKRIYQSNMLNRYLINVTFEGR--NLSFSEDGYQMHPKLVIILLNK 369
I ++ C Q + R L V +G N+ F G +++ + + L K
Sbjct: 322 ISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFEL-K 380
Query: 370 ERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTC 429
+VG W D + P + +T E+ + + T+ E+P+V+
Sbjct: 381 STGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVTTIMESPYVMY---------- 430
Query: 430 MRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKK 489
K + E +G+C+D+ +I+K + Y + +V +GK+G +
Sbjct: 431 ---------------KKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGAR 475
Query: 490 INGT--WNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSR-SNGTVS 546
T WNGM+GE+V +A +A+ LTI R EV+DFS PF+ GIS+M+ +
Sbjct: 476 DADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG 535
Query: 547 PSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYN-RCLADGREPGGPS------ 599
+FL+P + ++W M V I +V +F+ FSP ++ DG+E GPS
Sbjct: 536 VFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKE--GPSDQPPNE 592
Query: 600 FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEY 659
F I ++W G + +P+ + +I+ VW FF +I ++SYTANLAAF+ E
Sbjct: 593 FGIFNSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERM 651
Query: 660 VDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN----YAEMHAYM-----GKFN 710
V + D Q +GT+ +GST+ R + Y +M YM F
Sbjct: 652 VSPIESAEDLAKQ------TEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFT 705
Query: 711 QRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDS 770
+ + K+ AF+ ++ + Y+ R + C + +G S GYG+A K S
Sbjct: 706 RTTAEGVARVRKSKGKFAFLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGVATPKGS 762
Query: 771 GWKRQVDLAILQLFGDGEMEELEALWL--TGIC--HNEKNEVMSSQLDIDNMAGVFYM-- 824
V+LA+L+L G +++L+ W G C + ++ +S L + N+AGVFY+
Sbjct: 763 SLGTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILV 822
Query: 825 --LGAAMALSLITF 836
LG AM ++LI F
Sbjct: 823 GGLGLAMLVALIEF 836
>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
precursor [Homo sapiens]
Length = 884
Score = 191 bits (485), Expect = 4e-48
Identities = 197/794 (24%), Positives = 337/794 (42%), Gaps = 117/794 (14%)
Query: 104 DQEAIAQILDFISA---QTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNI 160
D+ ++ + F SA +TP G ES Q PS+ +L++
Sbjct: 99 DKRSVHTLTSFCSALHISLITPSFPTEG----------ESQFVLQLRPSLR---GALLSL 145
Query: 161 MEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQL 220
++ Y+W F + GY + +N GW + + + + + D ++ +L
Sbjct: 146 LDHYEWNCFVFLYDTDRGYSILQAIMEKAGQN---GWHVSAICVENFN-DVSYRQLLEEL 201
Query: 221 KKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGD-------------TD 267
+ Q ++ C E I E SVG GY +I+ +L D T
Sbjct: 202 DRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTG 261
Query: 268 TVPAEFPTGLISVSYDEW------DYG--------LPARVRDGIAIITTAASDMLSEHSF 313
+F T ++ D W +Y A DG+ ++ + +
Sbjct: 262 FQLVDFNTPMVIKLMDRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKID 321
Query: 314 IPEPKSS--CYNTHEKRIYQSNMLNRYLINVTFEGR--NLSFSEDGYQMHPKLVIILLNK 369
I ++ C Q + R L V +G N+ F G +++ + + L K
Sbjct: 322 ISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFEL-K 380
Query: 370 ERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTC 429
+VG W D + P + +T E+ + + T+ E+P+V+
Sbjct: 381 STGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVTTIMESPYVMY---------- 430
Query: 430 MRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKK 489
K + E +G+C+D+ +I+K + Y + +V +GK+G +
Sbjct: 431 ---------------KKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGAR 475
Query: 490 INGT--WNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSR-SNGTVS 546
T WNGM+GE+V +A +A+ LTI R EV+DFS PF+ GIS+M+ +
Sbjct: 476 DADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG 535
Query: 547 PSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYN-RCLADGREPGGPS------ 599
+FL+P + ++W M V I +V +F+ FSP ++ DG+E GPS
Sbjct: 536 VFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKE--GPSDQPPNE 592
Query: 600 FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEY 659
F I ++W G + +P+ + +I+ VW FF +I ++SYTANLAAF+ E
Sbjct: 593 FGIFNSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERM 651
Query: 660 VDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN----YAEMHAYM-----GKFN 710
V + D Q +GT+ +GST+ R + Y +M YM F
Sbjct: 652 VSPIESAEDLAKQ------TEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFT 705
Query: 711 QRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDS 770
+ + K+ AF+ ++ + Y+ R + C + +G S GYG+A K S
Sbjct: 706 RTTAEGVARVRKSKGKFAFLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGVATPKGS 762
Query: 771 GWKRQVDLAILQLFGDGEMEELEALWL--TGICHN--EKNEVMSSQLDIDNMAGVFYM-- 824
V+LA+L+L G +++L+ W G C + ++ +S L + N+AGVFY+
Sbjct: 763 SLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILV 822
Query: 825 --LGAAMALSLITF 836
LG AM ++LI F
Sbjct: 823 GGLGLAMLVALIEF 836
>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
precursor [Homo sapiens]
Length = 905
Score = 190 bits (482), Expect = 1e-47
Identities = 143/493 (29%), Positives = 243/493 (49%), Gaps = 55/493 (11%)
Query: 365 ILLNKERKWERVGKWKDKS-LQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVD 423
I+ KE E++G W S L M + T+ + L + T+ E P+V+ D
Sbjct: 392 IISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSD 451
Query: 424 PLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN 483
+P Y +G+C+D+LK++S + F YD+ LV +
Sbjct: 452 -------------------------KPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPD 486
Query: 484 GKHGKKIN-GTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSN 542
GK+G + + G WNGM+ E++ RA +AV LTI R +V+DFS PF+ GIS++ + N
Sbjct: 487 GKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPN 546
Query: 543 GTVSPS--AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGY---NRCLADGREPGG 597
GT +P +FL P S D+W+ + + L VS V +FV F+P + + C D +
Sbjct: 547 GT-NPGVFSFLNPLSPDIWMYVLLACLGVSCV-LFVIARFTPYEWYNPHPCNPDS-DVVE 603
Query: 598 PSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQE 657
+FT+ + W G + + PK +++I+ +W FF +I ++SYTANLAAF+ E
Sbjct: 604 NNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVE 662
Query: 658 EYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGST----ERNIRNNYAEMHAYMGKFNQ-- 711
+ D Q +G V +GST +++ + Y +M A+M Q
Sbjct: 663 RMESPIDSADDLAKQ------TKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTA 716
Query: 712 --RGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKD 769
R D+ + + T A + ++ + Y+ R+ C L IG + S GYG+
Sbjct: 717 LVRNSDEGIQRVLTTDY-ALLMESTSIEYVTQRN--CNLTQIGG--LIDSKGYGVGTPIG 771
Query: 770 SGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAM 829
S ++ ++ +AILQL +G++ ++ W G E++ +S L ++N+ G+F +L A +
Sbjct: 772 SPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGL 831
Query: 830 ALSLITFICEHLF 842
LS+ I E ++
Sbjct: 832 VLSVFVAIGEFIY 844
>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
precursor [Homo sapiens]
Length = 918
Score = 190 bits (482), Expect = 1e-47
Identities = 140/485 (28%), Positives = 240/485 (49%), Gaps = 55/485 (11%)
Query: 373 WERVGKWKDKS-LQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMR 431
W+++G W S L M + T+ + L + T+ E P+V+ D
Sbjct: 415 WKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSD-------- 466
Query: 432 NTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKIN 491
+P Y +G+C+D+LK++S + F YD+ LV +GK+G + +
Sbjct: 467 -----------------KPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQND 509
Query: 492 -GTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPS-- 548
G WNGM+ E++ RA +AV LTI R +V+DFS PF+ GIS++ + NGT +P
Sbjct: 510 KGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGT-NPGVF 568
Query: 549 AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGY---NRCLADGREPGGPSFTIGKA 605
+FL P S D+W+ + + L VS V +FV F+P + + C D + +FT+ +
Sbjct: 569 SFLNPLSPDIWMYVLLACLGVSCV-LFVIARFTPYEWYNPHPCNPDS-DVVENNFTLLNS 626
Query: 606 IWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSG 665
W G + + PK +++I+ +W FF +I ++SYTANLAAF+ E +
Sbjct: 627 FWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDS 685
Query: 666 LSDKKFQRPNDFSPPFRFGTVPNGST----ERNIRNNYAEMHAYMGKFNQ----RGVDDA 717
D Q +G V +GST +++ + Y +M A+M Q R D+
Sbjct: 686 ADDLAKQ------TKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEG 739
Query: 718 LLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVD 777
+ + T A + ++ + Y+ R+ C L IG + S GYG+ S ++ ++
Sbjct: 740 IQRVLTTDY-ALLMESTSIEYVTQRN--CNLTQIGG--LIDSKGYGVGTPIGSPYRDKIT 794
Query: 778 LAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFI 837
+AILQL +G++ ++ W G E++ +S L ++N+ G+F +L A + LS+ I
Sbjct: 795 IAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAI 854
Query: 838 CEHLF 842
E ++
Sbjct: 855 GEFIY 859
>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
sapiens]
Length = 906
Score = 189 bits (481), Expect = 1e-47
Identities = 186/757 (24%), Positives = 337/757 (44%), Gaps = 102/757 (13%)
Query: 138 DESSMF-FQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVG 196
D S+ F Q P ++ +++I++ Y W F + G + + E +
Sbjct: 116 DTSNQFVLQLRPELQD---ALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKN--- 169
Query: 197 WELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTW 256
W++ V +L + ++G + L+K + ++++ C E I + G GY +
Sbjct: 170 WQVTAVNILTTT-EEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHY 228
Query: 257 IVPSLVAGD---------------------TDTVPAEFPT---GLISVSYDEWDYGLP-- 290
I+ +L D TDT+PA+ + + D+ P
Sbjct: 229 ILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKY 288
Query: 291 --ARVRDGIAIITTAASDMLSEHSFIPEPKSS--CYNTHEKRIYQSNMLNRYLINVTFEG 346
A DG+ ++ A + + I ++ C Q + R L V FEG
Sbjct: 289 TSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEG 348
Query: 347 R--NLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDD 404
N+ F+E G + + L +I + K ++G W + + + + ++
Sbjct: 349 LTGNVQFNEKGRRTNYTLHVIEM-KHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNR 407
Query: 405 HLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDI 464
+ T+ E P+V+++ N+ + Y +G+C+++
Sbjct: 408 TYIVTTILEDPYVMLKK--------------------NANQFEGNDRY-----EGYCVEL 442
Query: 465 LKKISKSVKFTYDLYLVTNGKHGKKINGT--WNGMIGEVVMKRAYMAVGSLTINEERSEV 522
+I+K V ++Y L +V++GK+G + T WNGM+GE+V RA +AV LTI R EV
Sbjct: 443 AAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEV 502
Query: 523 VDFSVPFIETGISVMVSR-SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFS 581
+DFS PF+ GIS+M+ + +FL+P + ++W M V I +V +F+ FS
Sbjct: 503 IDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFS 561
Query: 582 PV-GYNRCLADGRE----PGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWA 636
P ++ +GR+ F I ++W G + +P+ + +I+ VW
Sbjct: 562 PYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWW 620
Query: 637 FFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIR 696
FF +I ++SYTANLAAF+ E V + D Q +GT+ GST+ R
Sbjct: 621 FFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLEAGSTKEFFR 674
Query: 697 NN----YAEMHAYMGKFNQ----RGVDDALLSLKTGK-LDAFIYDAAVLNYMAGRDEGCK 747
+ + +M YM R ++ ++ ++ K A++ ++ + Y+ R + C
Sbjct: 675 RSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQR-KPCD 733
Query: 748 LVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL--TGICHNEK 805
+ +G S GYGIA K S + V+LA+L+L G +++L++ W G C ++
Sbjct: 734 TMKVGGN--LDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGSKD 791
Query: 806 --NEVMSSQLDIDNMAGVFYM----LGAAMALSLITF 836
++ +S L + N+AGVFY+ LG AM ++LI F
Sbjct: 792 SGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEF 828
>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
sapiens]
Length = 906
Score = 187 bits (475), Expect = 6e-47
Identities = 186/757 (24%), Positives = 335/757 (44%), Gaps = 102/757 (13%)
Query: 138 DESSMF-FQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVG 196
D S+ F Q P ++ +++I++ Y W F + G + + E +
Sbjct: 116 DTSNQFVLQLRPELQD---ALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKN--- 169
Query: 197 WELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTW 256
W++ V +L + ++G + L+K + ++++ C E I + G GY +
Sbjct: 170 WQVTAVNILTTT-EEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHY 228
Query: 257 IVPSLVAGD---------------------TDTVPAEFPT---GLISVSYDEWDYGLP-- 290
I+ +L D TDT+PA+ + + D+ P
Sbjct: 229 ILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKY 288
Query: 291 --ARVRDGIAIITTAASDMLSEHSFIPEPKSS--CYNTHEKRIYQSNMLNRYLINVTFEG 346
A DG+ ++ A + + I ++ C Q + R L V FEG
Sbjct: 289 TSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEG 348
Query: 347 R--NLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDD 404
N+ F+E G + + L +I + K ++G W + + + + ++
Sbjct: 349 LTGNVQFNEKGRRTNYTLHVIEM-KHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNR 407
Query: 405 HLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDI 464
+ T+ E P+V+++ N+ + Y +G+C+++
Sbjct: 408 TYIVTTILEDPYVMLKK--------------------NANQFEGNDRY-----EGYCVEL 442
Query: 465 LKKISKSVKFTYDLYLVTNGKHGKKINGT--WNGMIGEVVMKRAYMAVGSLTINEERSEV 522
+I+K V ++Y L +V++GK+G + T WNGM+GE+V RA +AV LTI R EV
Sbjct: 443 AAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEV 502
Query: 523 VDFSVPFIETGISVMVSR-SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFS 581
+DFS PF+ GIS+M+ + +FL+P + ++W M V I +V +F+ FS
Sbjct: 503 IDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFS 561
Query: 582 PV-GYNRCLADGRE----PGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWA 636
P ++ +GR+ F I ++W G + +P+ + +I+ VW
Sbjct: 562 PYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWW 620
Query: 637 FFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIR 696
FF +I ++SYTANLAAF+ E V + D Q +GT+ GST+ R
Sbjct: 621 FFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLEAGSTKEFFR 674
Query: 697 NN----YAEMHAYMGKFNQ----RGVDDALLSLKTGK-LDAFIYDAAVLNYMAGRDEGCK 747
+ + +M YM R ++ ++ ++ K A++ ++ + Y+ R + C
Sbjct: 675 RSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQR-KPCD 733
Query: 748 LVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL--TGICHN-- 803
+ +G S GYGIA K S + V+LA+L+L G +++L+ W G C +
Sbjct: 734 TMKVGGN--LDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGG 791
Query: 804 EKNEVMSSQLDIDNMAGVFYM----LGAAMALSLITF 836
++ +S L + N+AGVFY+ LG AM ++LI F
Sbjct: 792 GDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEF 828
>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
sapiens]
Length = 836
Score = 187 bits (475), Expect = 6e-47
Identities = 183/740 (24%), Positives = 329/740 (44%), Gaps = 100/740 (13%)
Query: 157 MLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKI 216
+L+++E Y W F+ + G + S E W++ + + +++ D D
Sbjct: 89 LLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKK---WQVTAINVGNINNDKKDEMY 145
Query: 217 QNQLKKLQ---SPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEF 273
++ + L+ ++L C +++ I + ++G GY +I+ +L D D + +F
Sbjct: 146 RSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQF 205
Query: 274 PTGLIS----VSYDE---------W------DYG---------LPARVRDGIAIITTAAS 305
+S V YD+ W +Y A D + ++T A
Sbjct: 206 GGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFR 265
Query: 306 DMLSEHSFIPEPKSS--CYNTHEKRIYQSNMLNRYLINVTFEGR--NLSFSEDGYQMHPK 361
++ + I ++ C Q + R L V EG N+ F ++G +++
Sbjct: 266 NLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYT 325
Query: 362 LVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVES 421
+ I+ L K ++G W + + +T E+ + + T+ E+P+V+++
Sbjct: 326 INIMEL-KTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKK 384
Query: 422 VDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLV 481
++ N+ E G+C+D+ +I+K F Y L +V
Sbjct: 385 ---------------NHEMLEGNERYE----------GYCVDLAAEIAKHCGFKYKLTIV 419
Query: 482 TNGKHGKKINGT--WNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVS 539
+GK+G + T WNGM+GE+V +A +A+ LTI R EV+DFS PF+ GIS+M+
Sbjct: 420 GDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIK 479
Query: 540 R-SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYN-RCLADGREPGG 597
+ +FL+P + ++W M V I +V +F+ FSP ++ DGRE
Sbjct: 480 KPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQS 538
Query: 598 P----SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAF 653
F I ++W G + +P+ + +I+ VW FF +I ++SYTANLAAF
Sbjct: 539 SESTNEFGIFNSLWFSLGAFMRQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAF 597
Query: 654 MIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN----YAEMHAYM--- 706
+ E V + D Q +GT+ +GST+ R + + +M YM
Sbjct: 598 LTVERMVSPIESAEDLSKQ------TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSA 651
Query: 707 --GKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGI 764
F + + K+ A++ ++ + Y+ R + C + +G S GYGI
Sbjct: 652 EPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGI 708
Query: 765 AIQKDSGWKRQVDLAILQLFGDGEMEELEALWL--TGIC--HNEKNEVMSSQLDIDNMAG 820
A K S + V+LA+L+L G +++L+ W G C + ++ +S L + N+AG
Sbjct: 709 ATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAG 768
Query: 821 VFYM----LGAAMALSLITF 836
VFY+ LG AM ++LI F
Sbjct: 769 VFYILVGGLGLAMLVALIEF 788
>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
precursor [Homo sapiens]
Length = 883
Score = 187 bits (475), Expect = 6e-47
Identities = 183/740 (24%), Positives = 329/740 (44%), Gaps = 100/740 (13%)
Query: 157 MLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKI 216
+L+++E Y W F+ + G + S E W++ + + +++ D D
Sbjct: 136 LLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKK---WQVTAINVGNINNDKKDEMY 192
Query: 217 QNQLKKLQ---SPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEF 273
++ + L+ ++L C +++ I + ++G GY +I+ +L D D + +F
Sbjct: 193 RSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQF 252
Query: 274 PTGLIS----VSYDE---------W------DYG---------LPARVRDGIAIITTAAS 305
+S V YD+ W +Y A D + ++T A
Sbjct: 253 GGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFR 312
Query: 306 DMLSEHSFIPEPKSS--CYNTHEKRIYQSNMLNRYLINVTFEGR--NLSFSEDGYQMHPK 361
++ + I ++ C Q + R L V EG N+ F ++G +++
Sbjct: 313 NLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYT 372
Query: 362 LVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVES 421
+ I+ L K ++G W + + +T E+ + + T+ E+P+V+++
Sbjct: 373 INIMEL-KTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKK 431
Query: 422 VDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLV 481
++ N+ E G+C+D+ +I+K F Y L +V
Sbjct: 432 ---------------NHEMLEGNERYE----------GYCVDLAAEIAKHCGFKYKLTIV 466
Query: 482 TNGKHGKKINGT--WNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVS 539
+GK+G + T WNGM+GE+V +A +A+ LTI R EV+DFS PF+ GIS+M+
Sbjct: 467 GDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIK 526
Query: 540 R-SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYN-RCLADGREPGG 597
+ +FL+P + ++W M V I +V +F+ FSP ++ DGRE
Sbjct: 527 KPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQS 585
Query: 598 P----SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAF 653
F I ++W G + +P+ + +I+ VW FF +I ++SYTANLAAF
Sbjct: 586 SESTNEFGIFNSLWFSLGAFMRQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAF 644
Query: 654 MIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN----YAEMHAYM--- 706
+ E V + D Q +GT+ +GST+ R + + +M YM
Sbjct: 645 LTVERMVSPIESAEDLSKQ------TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSA 698
Query: 707 --GKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGI 764
F + + K+ A++ ++ + Y+ R + C + +G S GYGI
Sbjct: 699 EPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGI 755
Query: 765 AIQKDSGWKRQVDLAILQLFGDGEMEELEALWL--TGIC--HNEKNEVMSSQLDIDNMAG 820
A K S + V+LA+L+L G +++L+ W G C + ++ +S L + N+AG
Sbjct: 756 ATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAG 815
Query: 821 VFYM----LGAAMALSLITF 836
VFY+ LG AM ++LI F
Sbjct: 816 VFYILVGGLGLAMLVALIEF 835
>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
precursor [Homo sapiens]
Length = 883
Score = 186 bits (472), Expect = 1e-46
Identities = 183/740 (24%), Positives = 329/740 (44%), Gaps = 100/740 (13%)
Query: 157 MLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKI 216
+L+++E Y W F+ + G + S E W++ + + +++ D D
Sbjct: 136 LLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKK---WQVTAINVGNINNDKKDEMY 192
Query: 217 QNQLKKLQ---SPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEF 273
++ + L+ ++L C +++ I + ++G GY +I+ +L D D + +F
Sbjct: 193 RSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQF 252
Query: 274 PTGLIS----VSYDE---------W------DYG---------LPARVRDGIAIITTAAS 305
+S V YD+ W +Y A D + ++T A
Sbjct: 253 GGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFR 312
Query: 306 DMLSEHSFIPEPKSS--CYNTHEKRIYQSNMLNRYLINVTFEGR--NLSFSEDGYQMHPK 361
++ + I ++ C Q + R L V EG N+ F ++G +++
Sbjct: 313 NLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYT 372
Query: 362 LVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVES 421
+ I+ L K ++G W + + +T E+ + + T+ E+P+V+++
Sbjct: 373 INIMEL-KTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKK 431
Query: 422 VDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLV 481
++ N+ E G+C+D+ +I+K F Y L +V
Sbjct: 432 ---------------NHEMLEGNERYE----------GYCVDLAAEIAKHCGFKYKLTIV 466
Query: 482 TNGKHGKKINGT--WNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVS 539
+GK+G + T WNGM+GE+V +A +A+ LTI R EV+DFS PF+ GIS+M+
Sbjct: 467 GDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIK 526
Query: 540 R-SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYN-RCLADGREPGG 597
+ +FL+P + ++W M V I +V +F+ FSP ++ DGRE
Sbjct: 527 KPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQS 585
Query: 598 P----SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAF 653
F I ++W G + +P+ + +I+ VW FF +I ++SYTANLAAF
Sbjct: 586 SESTNEFGIFNSLWFSLGAFMRQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAF 644
Query: 654 MIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN----YAEMHAYM--- 706
+ E V + D Q +GT+ +GST+ R + + +M YM
Sbjct: 645 LTVERMVSPIESAEDLSKQ------TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSA 698
Query: 707 --GKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGI 764
F + + K+ A++ ++ + Y+ R + C + +G S GYGI
Sbjct: 699 EPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGI 755
Query: 765 AIQKDSGWKRQVDLAILQLFGDGEMEELEALWL--TGICHN--EKNEVMSSQLDIDNMAG 820
A K S + V+LA+L+L G +++L+ W G C + ++ +S L + N+AG
Sbjct: 756 ATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAG 815
Query: 821 VFYM----LGAAMALSLITF 836
VFY+ LG AM ++LI F
Sbjct: 816 VFYILVGGLGLAMLVALIEF 835
>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
[Homo sapiens]
Length = 919
Score = 181 bits (460), Expect = 4e-45
Identities = 143/497 (28%), Positives = 240/497 (48%), Gaps = 64/497 (12%)
Query: 365 ILLNKERKWERVGKWKDKS-LQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVD 423
I+ KE E+VG W L + R T+ + L + T+ E PFV+ D
Sbjct: 394 IISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSD 453
Query: 424 PLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN 483
R + N E G+CID+LK+++ + F+Y++ LV +
Sbjct: 454 ---------------RTLYGNDRFE----------GYCIDLLKELAHILGFSYEIRLVED 488
Query: 484 GKHGKKIN-GTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSN 542
GK+G + + G WNGM+ E++ +A +AV LTI R + +DFS PF+ G+S++ + N
Sbjct: 489 GKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPN 548
Query: 543 GTVSPS--AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGP-- 598
GT +PS +FL P S D+W+ + + L VS V +FV FSP Y A PG
Sbjct: 549 GT-NPSVFSFLNPLSPDIWMYVLLAYLGVSCV-LFVIARFSP--YEWYDAHPCNPGSEVV 604
Query: 599 --SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQ 656
+FT+ + W G + + PK +++I+ +W FF +I ++SYTANLAAF+
Sbjct: 605 ENNFTLLNSFWFGMGSLMQQGSELM-PKALSTRIIGGIWWFFTLIIISSYTANLAAFLTV 663
Query: 657 EEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGST----ERNIRNNYAEMHAYMG----- 707
E + D Q +G V +G+T +++ + + +M A+M
Sbjct: 664 ERMESPIDSADDLAKQ------TKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSA 717
Query: 708 --KFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIA 765
K N+ G+ AL + A + ++ + Y+ R+ C L IG + S GYGI
Sbjct: 718 LVKNNEEGIQRALTADY-----ALLMESTTIEYVTQRN--CNLTQIGG--LIDSKGYGIG 768
Query: 766 IQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYML 825
S ++ ++ +AILQL + ++ ++ W G E+ +S L I + G+F +L
Sbjct: 769 TPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVL 828
Query: 826 GAAMALSLITFICEHLF 842
A + LS++ + E ++
Sbjct: 829 AAGLVLSVLVAVGEFVY 845
>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
precursor [Homo sapiens]
Length = 894
Score = 179 bits (453), Expect = 2e-44
Identities = 132/408 (32%), Positives = 207/408 (50%), Gaps = 42/408 (10%)
Query: 458 KGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGT--WNGMIGEVVMKRAYMAVGSLTI 515
+G+C+D+ +I+K V+ Y L +V +GK+G + T WNGM+GE+V RA +AV LTI
Sbjct: 452 EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTI 511
Query: 516 NEERSEVVDFSVPFIETGISVMVSR-SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAV 574
R EV+DFS PF+ GIS+M+ + +FL+P + ++W M V I +V +
Sbjct: 512 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 570
Query: 575 FVFEYFSPVGYNRCLADG----REPGGP-----SFTIGKAIWLLWGLVFNNSVPVQNPKG 625
F+ FSP Y L D R+P P F I ++W G + +P+
Sbjct: 571 FLVSRFSP--YEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDI-SPRS 627
Query: 626 TTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGT 685
+ +I+ VW FF +I ++SYTANLAAF+ E V + D Q +GT
Sbjct: 628 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGT 681
Query: 686 VPNGSTERNIRNN----YAEMHAYM-----GKFNQRGVDDALLSLKTGKLDAFIYDAAVL 736
+ +GST+ R + Y +M +YM F + D K+ AF+ ++ +
Sbjct: 682 LDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMN 741
Query: 737 NYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALW 796
Y+ R + C + +G S GYG+A K S V+LA+L+L G +++L+ W
Sbjct: 742 EYIEQR-KPCDTMKVGGN--LDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKW 798
Query: 797 L--TGIC--HNEKNEVMSSQLDIDNMAGVFYM----LGAAMALSLITF 836
G C + ++ +S L + N+AGVFY+ LG AM ++LI F
Sbjct: 799 WYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEF 846
>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
precursor [Homo sapiens]
Length = 894
Score = 178 bits (451), Expect = 4e-44
Identities = 132/408 (32%), Positives = 207/408 (50%), Gaps = 42/408 (10%)
Query: 458 KGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGT--WNGMIGEVVMKRAYMAVGSLTI 515
+G+C+D+ +I+K V+ Y L +V +GK+G + T WNGM+GE+V RA +AV LTI
Sbjct: 452 EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTI 511
Query: 516 NEERSEVVDFSVPFIETGISVMVSR-SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAV 574
R EV+DFS PF+ GIS+M+ + +FL+P + ++W M V I +V +
Sbjct: 512 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 570
Query: 575 FVFEYFSPVGYNRCLADG----REPGGP-----SFTIGKAIWLLWGLVFNNSVPVQNPKG 625
F+ FSP Y L D R+P P F I ++W G + +P+
Sbjct: 571 FLVSRFSP--YEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDI-SPRS 627
Query: 626 TTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGT 685
+ +I+ VW FF +I ++SYTANLAAF+ E V + D Q +GT
Sbjct: 628 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGT 681
Query: 686 VPNGSTERNIRNN----YAEMHAYM-----GKFNQRGVDDALLSLKTGKLDAFIYDAAVL 736
+ +GST+ R + Y +M +YM F + D K+ AF+ ++ +
Sbjct: 682 LDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMN 741
Query: 737 NYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALW 796
Y+ R + C + +G S GYG+A K S V+LA+L+L G +++L+ W
Sbjct: 742 EYIEQR-KPCDTMKVGGN--LDSKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKW 798
Query: 797 L--TGICHN--EKNEVMSSQLDIDNMAGVFYM----LGAAMALSLITF 836
G C + ++ +S L + N+AGVFY+ LG AM ++LI F
Sbjct: 799 WYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEF 846
>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
Length = 956
Score = 174 bits (441), Expect = 6e-43
Identities = 132/455 (29%), Positives = 223/455 (49%), Gaps = 53/455 (11%)
Query: 458 KGFCIDILKKISKSVKFTYDLYLVTNGKHG-KKINGTWNGMIGEVVMKRAYMAVGSLTIN 516
+GFC+D+LK++++ ++F Y + LV +G +G + NGTW GM+GE++ ++A +AV LTI
Sbjct: 445 EGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTIT 504
Query: 517 EERSEVVDFSVPFIETGISVM----VSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAV 572
ER +V+DFS PF+ GIS++ + R G S FL+PFS VW+ M + L VS V
Sbjct: 505 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPGVWLFMLLAYLAVSCV 561
Query: 573 AVFV-----FEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTT 627
V +E++SP + C +++G ++W G + P+ +
Sbjct: 562 LFLVARLTPYEWYSP---HPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIA-PRALS 617
Query: 628 SKIMVSVWAFFAVIFLASYTANLAAFMIQEEY---VDQVSGLSDKKFQRPNDFSPPFRFG 684
++ + VW F +I ++SYTANLAAF+ + ++ V L+D+ +G
Sbjct: 618 TRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQ---------TAIEYG 668
Query: 685 TVPNGSTERNIRNN----YAEMHAYM--------GKFNQRGVDDALLSLKTGKLDAFIYD 732
T+ GS+ +N+ Y M YM K + G+ L S AF+ +
Sbjct: 669 TIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNY-----AFLLE 723
Query: 733 AAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEEL 792
+ + Y R C L IG + + GYGI + S ++ + DLAILQL + +E L
Sbjct: 724 STMNEYY--RQRNCNLTQIGG--LLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEIL 779
Query: 793 EALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHCFMG 852
+ W G ++ + + L ++N+ G+F +L + +++ + E F W RH
Sbjct: 780 KRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLE--FLWTLRHSEAT 837
Query: 853 VCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSP 887
S MV + R I C + R++ + P
Sbjct: 838 EVSVCQEMVTEL-RSIILCQDSIHPRRRRAAVPPP 871
>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
Length = 1007
Score = 166 bits (421), Expect = 1e-40
Identities = 131/457 (28%), Positives = 218/457 (47%), Gaps = 70/457 (15%)
Query: 406 LSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDIL 465
L +VT+ E PFV+V +EN + Y +GF ID+L
Sbjct: 443 LRVVTVLEEPFVMV----------------------SENVLGKPKKY-----QGFSIDVL 475
Query: 466 KKISKSVKFTYDLYLVTNGKHGK-KINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVD 524
+S + F Y++Y+ + K+G + +GTWNG++GE+V KRA + + +LTI +R VVD
Sbjct: 476 DALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVD 535
Query: 525 FSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVG 584
F+ +++ + V++ R+ TV A L PF +W + +L+V + V++ + +P
Sbjct: 536 FTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLV-GLLVYLLNWLNPPR 594
Query: 585 YNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGT-TSKIMVSVWAFFAVIFL 643
+ S T+ ++W ++G V P T +++M+ W FA+I +
Sbjct: 595 L-------QMGSMTSTTLYNSMWFVYGSFVQQGGEV--PYTTLATRMMMGAWWLFALIVI 645
Query: 644 ASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIR------- 696
+SYTANLAAF+ + L D Q +GTV + + ++R
Sbjct: 646 SSYTANLAAFLTITRIESSIQSLQDLSKQ------TEIPYGTVLDSAVYEHVRMKGLNPF 699
Query: 697 ---NNYAEMHAYMGKFNQRGVDDALLSLKTGKLD------AFIYDAAVLNYMAGRDEGCK 747
+ Y++M + + N G ++ +L + G AF++DAAVL Y+A D C
Sbjct: 700 ERDSMYSQMWRMINRSN--GSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCS 757
Query: 748 LVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALW--LTGIC---H 802
TIG+ A GYGIA+Q S ++ IL+L +G+M+ L+ W G C
Sbjct: 758 FYTIGN--TVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYS 815
Query: 803 NEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICE 839
+ + LDI + AGVF +L A + LS + E
Sbjct: 816 SVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLE 852
>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
Length = 980
Score = 166 bits (419), Expect = 2e-40
Identities = 115/408 (28%), Positives = 206/408 (50%), Gaps = 38/408 (9%)
Query: 458 KGFCIDILKKISKSVKFTYDLYLVTNGKHGK-KINGTWNGMIGEVVMKRAYMAVGSLTIN 516
+GFC+D+L+++++ ++F Y L LV +G +G + NG+W GM+GE++ ++A +AV + TI
Sbjct: 444 EGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTIT 503
Query: 517 EERSEVVDFSVPFIETGISVM----VSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAV 572
ER +V+DFS PF+ GIS++ + R G S FL+PFS VW+ M + L VS V
Sbjct: 504 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPAVWLFMLLAYLAVSCV 560
Query: 573 AVFV-----FEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTT 627
+E+++P + CL +T+G ++W G + P+ +
Sbjct: 561 LFLAARLSPYEWYNP---HPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIM-PRALS 616
Query: 628 SKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVP 687
++ + VW F +I ++SYTANLAAF+ + V D Q +GT+
Sbjct: 617 TRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQ------TNIEYGTIH 670
Query: 688 NGSTERNIRNNYAEMHAYMGKFNQ--------RGVDDALLSLKTGKLDAFIYDAAVLNYM 739
GST +N+ + + M + Q + ++ + + + AF+ ++ + Y
Sbjct: 671 AGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRY-AFLLESTMNEY- 728
Query: 740 AGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTG 799
R C L IG + + GYGI + S ++ ++ LAILQL + +E L+ W G
Sbjct: 729 -HRRLNCNLTQIGG--LLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEG 785
Query: 800 ICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFR 847
++ + + L ++N+ G+F +L + +++ + E F W R
Sbjct: 786 GRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVME--FIWSTR 831
>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
sapiens]
Length = 1009
Score = 162 bits (410), Expect = 2e-39
Identities = 125/466 (26%), Positives = 211/466 (45%), Gaps = 66/466 (14%)
Query: 406 LSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDIL 465
L +VT+ E PFV+V EN + Y KGF ID+L
Sbjct: 439 LKVVTVLEEPFVMV----------------------AENILGQPKRY-----KGFSIDVL 471
Query: 466 KKISKSVKFTYDLYLVTNGKHGKKINGT-WNGMIGEVVMKRAYMAVGSLTINEERSEVVD 524
++K++ F Y++Y +G++G +++ T WNGMIGE++ KRA +A+ ++TI ER VVD
Sbjct: 472 DALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVD 531
Query: 525 FSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVG 584
FS +++ + +++ + +S + PF VW + + +V V +FV V
Sbjct: 532 FSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVV-GVLIFVLNRIQAV- 589
Query: 585 YNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLA 644
R + + S T+ AIW+++G F + +I++ W F +I +
Sbjct: 590 --RAQSAAQPRPSASATLHSAIWIVYG-AFVQQGGESSVNSMAMRIVMGSWWLFTLIVCS 646
Query: 645 SYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIR-------- 696
SYTANLAAF+ + + D Q +GTV + + R
Sbjct: 647 SYTANLAAFLTVSRMDNPIRTFQDLSKQ------VEMSYGTVRDSAVYEYFRAKGTNPLE 700
Query: 697 --NNYAEMHAYMGKFNQRGVDDALLSLKTGKLD------AFIYDAAVLNYMAGRDEGCKL 748
+ +AE+ + K G D+ + S G AF++D AV+ Y A D+ C +
Sbjct: 701 QDSTFAELWRTISK--NGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSV 758
Query: 749 VTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEV 808
IG+ +S GYGIA+Q S ++ IL+L G+++ L+ W + +
Sbjct: 759 TVIGNS--ISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSH 816
Query: 809 MSSQLD-----IDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHC 849
S+Q D + + AGVF +L + L+ + E +W C
Sbjct: 817 ASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALE--LWWNSNRC 860
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 38.9 bits (89), Expect = 0.037
Identities = 33/123 (26%), Positives = 55/123 (44%), Gaps = 29/123 (23%)
Query: 1151 LTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVVSGVPAPWEKNLTNVEWEDRS 1210
+ ++ +E+ D + D GGGPC + TGD+ VV ++ V ED
Sbjct: 164 IIEVEEEQEDPYLNDRCRGGGPCKQQCR---DTGDE--VVCSCFVGYQLLSDGVSCEDV- 217
Query: 1211 GGNFCRSCPSKLHNYSTTVTGQNSGR--QACI------RCEACKKAGNLYDISEDNSLQE 1262
N C +TG +S R ++CI RC+ G Y+++EDNS ++
Sbjct: 218 --NEC-------------ITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKD 262
Query: 1263 LDQ 1265
+D+
Sbjct: 263 IDE 265
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,571,415
Number of Sequences: 37866
Number of extensions: 2627212
Number of successful extensions: 7252
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 7023
Number of HSP's gapped (non-prelim): 66
length of query: 1484
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1369
effective length of database: 13,892,928
effective search space: 19019418432
effective search space used: 19019418432
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.