Search of human proteins with 15991827

Search of human proteins with 15991827

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15991827 hexokinase 1 isoform HKI-R [Homo sapiens]
         (916 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|15991827 hexokinase 1 isoform HKI-R [Homo sapiens]                1832   0.0  
gi|15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]            1788   0.0  
gi|15991831 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]            1788   0.0  
gi|188497750 hexokinase 1 isoform HKI-td [Homo sapiens]              1788   0.0  
gi|188497754 hexokinase 1 isoform HKI [Homo sapiens]                 1788   0.0  
gi|15553127 hexokinase 2 [Homo sapiens]                              1368   0.0  
gi|156151420 hexokinase domain containing 1 [Homo sapiens]           1323   0.0  
gi|194097330 hexokinase 3 [Homo sapiens]                              944   0.0  
gi|15967161 glucokinase isoform 3 [Homo sapiens]                      506   e-143
gi|4503951 glucokinase isoform 1 [Homo sapiens]                       504   e-142
gi|15967159 glucokinase isoform 2 [Homo sapiens]                      503   e-142
gi|164663810 ribosomal modification protein rimK-like family mem...    35   0.42 
gi|134254462 ribosomal modification protein rimK-like family mem...    33   0.93 
gi|21389509 KPL2 protein isoform 2 [Homo sapiens]                      32   2.7  
gi|145699133 KPL2 protein isoform 1 [Homo sapiens]                     32   2.7  
gi|42415492 chromosome 14 open reading frame 106 [Homo sapiens]        30   7.9  

>gi|15991827 hexokinase 1 isoform HKI-R [Homo sapiens]
          Length = 916

 Score = 1832 bits (4746), Expect = 0.0
 Identities = 916/916 (100%), Positives = 916/916 (100%)

Query: 1   MDCEHSLSLPCRGAEAWEIGIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATV 60
           MDCEHSLSLPCRGAEAWEIGIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATV
Sbjct: 1   MDCEHSLSLPCRGAEAWEIGIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATV 60

Query: 61  KMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHG 120
           KMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHG
Sbjct: 61  KMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHG 120

Query: 121 SGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVE 180
           SGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVE
Sbjct: 121 SGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVE 180

Query: 181 GADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEE 240
           GADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEE
Sbjct: 181 GADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEE 240

Query: 241 LRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMY 300
           LRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMY
Sbjct: 241 LRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMY 300

Query: 301 LGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGV 360
           LGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGV
Sbjct: 301 LGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGV 360

Query: 361 EPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHP 420
           EPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHP
Sbjct: 361 EPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHP 420

Query: 421 QYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTK 480
           QYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTK
Sbjct: 421 QYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTK 480

Query: 481 DMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVL 540
           DMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVL
Sbjct: 481 DMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVL 540

Query: 541 LVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFT 600
           LVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFT
Sbjct: 541 LVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFT 600

Query: 601 FSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGT 660
           FSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGT
Sbjct: 601 FSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGT 660

Query: 661 MMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDI 720
           MMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDI
Sbjct: 661 MMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDI 720

Query: 721 RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGI 780
           RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGI
Sbjct: 721 RTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGI 780

Query: 781 FETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAV 840
           FETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAV
Sbjct: 781 FETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAV 840

Query: 841 VDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGA 900
           VDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGA
Sbjct: 841 VDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGA 900

Query: 901 ALITAVGVRLRTEASS 916
           ALITAVGVRLRTEASS
Sbjct: 901 ALITAVGVRLRTEASS 916


>gi|15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
          Length = 921

 Score = 1788 bits (4632), Expect = 0.0
 Identities = 897/899 (99%), Positives = 897/899 (99%)

Query: 18  EIGIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG 77
           E  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG
Sbjct: 23  ESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG 82

Query: 78  DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM 137
           DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM
Sbjct: 83  DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM 142

Query: 138 EKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGD 197
           EKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGD
Sbjct: 143 EKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGD 202

Query: 198 YDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN 257
           YDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN
Sbjct: 203 YDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN 262

Query: 258 TEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGL 317
           TEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGL
Sbjct: 263 TEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGL 322

Query: 318 LFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIV 377
           LFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIV
Sbjct: 323 LFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIV 382

Query: 378 SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDS 437
           SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDS
Sbjct: 383 SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDS 442

Query: 438 DVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELG 497
           DVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELG
Sbjct: 443 DVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELG 502

Query: 498 LRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNK 557
           LRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNK
Sbjct: 503 LRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNK 562

Query: 558 IYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILIT 617
           IYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILIT
Sbjct: 563 IYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILIT 622

Query: 618 WTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIV 677
           WTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIV
Sbjct: 623 WTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIV 682

Query: 678 GTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGK 737
           GTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGK
Sbjct: 683 GTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGK 742

Query: 738 QRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALL 797
           QRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALL
Sbjct: 743 QRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALL 802

Query: 798 QVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTV 857
           QVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTV
Sbjct: 803 QVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTV 862

Query: 858 GVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 916
           GVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS
Sbjct: 863 GVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 921


>gi|15991831 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
          Length = 921

 Score = 1788 bits (4632), Expect = 0.0
 Identities = 897/899 (99%), Positives = 897/899 (99%)

Query: 18  EIGIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG 77
           E  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG
Sbjct: 23  ESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG 82

Query: 78  DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM 137
           DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM
Sbjct: 83  DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM 142

Query: 138 EKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGD 197
           EKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGD
Sbjct: 143 EKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGD 202

Query: 198 YDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN 257
           YDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN
Sbjct: 203 YDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN 262

Query: 258 TEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGL 317
           TEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGL
Sbjct: 263 TEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGL 322

Query: 318 LFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIV 377
           LFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIV
Sbjct: 323 LFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIV 382

Query: 378 SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDS 437
           SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDS
Sbjct: 383 SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDS 442

Query: 438 DVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELG 497
           DVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELG
Sbjct: 443 DVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELG 502

Query: 498 LRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNK 557
           LRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNK
Sbjct: 503 LRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNK 562

Query: 558 IYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILIT 617
           IYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILIT
Sbjct: 563 IYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILIT 622

Query: 618 WTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIV 677
           WTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIV
Sbjct: 623 WTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIV 682

Query: 678 GTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGK 737
           GTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGK
Sbjct: 683 GTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGK 742

Query: 738 QRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALL 797
           QRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALL
Sbjct: 743 QRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALL 802

Query: 798 QVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTV 857
           QVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTV
Sbjct: 803 QVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTV 862

Query: 858 GVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 916
           GVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS
Sbjct: 863 GVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 921


>gi|188497750 hexokinase 1 isoform HKI-td [Homo sapiens]
          Length = 905

 Score = 1788 bits (4631), Expect = 0.0
 Identities = 896/896 (100%), Positives = 896/896 (100%)

Query: 21  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80
           IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI
Sbjct: 10  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 69

Query: 81  ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 140
           ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR
Sbjct: 70  ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 129

Query: 141 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 200
           KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA
Sbjct: 130 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 189

Query: 201 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 260
           NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW
Sbjct: 190 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 249

Query: 261 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 320
           GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE
Sbjct: 250 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 309

Query: 321 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 380
           GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR
Sbjct: 310 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 369

Query: 381 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 440
           SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR
Sbjct: 370 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 429

Query: 441 FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK 500
           FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK
Sbjct: 430 FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK 489

Query: 501 QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA 560
           QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA
Sbjct: 490 QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA 549

Query: 561 IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK 620
           IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK
Sbjct: 550 IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK 609

Query: 621 GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG 680
           GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG
Sbjct: 610 GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG 669

Query: 681 SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY 740
           SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY
Sbjct: 670 SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY 729

Query: 741 EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR 800
           EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR
Sbjct: 730 EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR 789

Query: 801 AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 860
           AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD
Sbjct: 790 AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 849

Query: 861 GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 916
           GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS
Sbjct: 850 GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 905



 Score =  494 bits (1271), Expect = e-139
 Identities = 235/445 (52%), Positives = 325/445 (73%)

Query: 466 HRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENG 525
           H  I++ L    L+ + L+++  R R EM+ GL +  +  A VKMLP+FVR  PDG+E G
Sbjct: 7   HDFIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG 66

Query: 526 DFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFL 585
           DF+ALDLGG++FR+L V++   K + V M +++Y  P  I+ G+G +LFDH+  C+ DF+
Sbjct: 67  DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM 126

Query: 586 DYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREE 645
           +   IK  ++P+GFTFSFPCQQ+ +D  ILITWTK FKA+   G DVV LL  AIK+R +
Sbjct: 127 EKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGD 186

Query: 646 FDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCIN 705
           +D ++VAVVNDTVGTMMTC Y++  CEVGLI+GTG+NACYMEE++++++VEGD+G+MCIN
Sbjct: 187 YDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN 246

Query: 706 MEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGF 765
            EWGAFGD+G L+DIRT +DR +D  SLN GKQ +EKM+SGMYLGE+VR IL+   K+G 
Sbjct: 247 TEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGL 306

Query: 766 LFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVV 825
           LF G+I+  L TRG F T  +S IE ++  L   + IL +LG+  + DD + V+ VC +V
Sbjct: 307 LFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIV 366

Query: 826 SRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKC 885
           S R+A L  A + A+++++R+N+G  RL  TVGVDG+LYK HP +SR  H+T++ L P  
Sbjct: 367 SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDS 426

Query: 886 NVSFLLSEDGSGKGAALITAVGVRL 910
           +V FLLSE GSGKGAA++TAV  RL
Sbjct: 427 DVRFLLSESGSGKGAAMVTAVAYRL 451


>gi|188497754 hexokinase 1 isoform HKI [Homo sapiens]
          Length = 917

 Score = 1788 bits (4631), Expect = 0.0
 Identities = 896/896 (100%), Positives = 896/896 (100%)

Query: 21  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80
           IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI
Sbjct: 22  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 81

Query: 81  ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 140
           ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR
Sbjct: 82  ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 141

Query: 141 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 200
           KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA
Sbjct: 142 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 201

Query: 201 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 260
           NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW
Sbjct: 202 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 261

Query: 261 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 320
           GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE
Sbjct: 262 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 321

Query: 321 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 380
           GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR
Sbjct: 322 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 381

Query: 381 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 440
           SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR
Sbjct: 382 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 441

Query: 441 FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK 500
           FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK
Sbjct: 442 FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK 501

Query: 501 QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA 560
           QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA
Sbjct: 502 QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA 561

Query: 561 IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK 620
           IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK
Sbjct: 562 IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK 621

Query: 621 GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG 680
           GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG
Sbjct: 622 GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG 681

Query: 681 SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY 740
           SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY
Sbjct: 682 SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY 741

Query: 741 EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR 800
           EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR
Sbjct: 742 EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR 801

Query: 801 AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 860
           AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD
Sbjct: 802 AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 861

Query: 861 GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 916
           GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS
Sbjct: 862 GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 917



 Score =  495 bits (1275), Expect = e-140
 Identities = 235/447 (52%), Positives = 328/447 (73%)

Query: 464 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 523
           +Q ++I++ L    L+ + L+++  R R EM+ GL +  +  A VKMLP+FVR  PDG+E
Sbjct: 17  DQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76

Query: 524 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 583
            GDF+ALDLGG++FR+L V++   K + V M +++Y  P  I+ G+G +LFDH+  C+ D
Sbjct: 77  KGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGD 136

Query: 584 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 643
           F++   IK  ++P+GFTFSFPCQQ+ +D  ILITWTK FKA+   G DVV LL  AIK+R
Sbjct: 137 FMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKR 196

Query: 644 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 703
            ++D ++VAVVNDTVGTMMTC Y++  CEVGLI+GTG+NACYMEE++++++VEGD+G+MC
Sbjct: 197 GDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256

Query: 704 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 763
           IN EWGAFGD+G L+DIRT +DR +D  SLN GKQ +EKM+SGMYLGE+VR IL+   K+
Sbjct: 257 INTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKE 316

Query: 764 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 823
           G LF G+I+  L TRG F T  +S IE ++  L   + IL +LG+  + DD + V+ VC 
Sbjct: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCT 376

Query: 824 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 883
           +VS R+A L  A + A+++++R+N+G  RL  TVGVDG+LYK HP +SR  H+T++ L P
Sbjct: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVP 436

Query: 884 KCNVSFLLSEDGSGKGAALITAVGVRL 910
             +V FLLSE GSGKGAA++TAV  RL
Sbjct: 437 DSDVRFLLSESGSGKGAAMVTAVAYRL 463


>gi|15553127 hexokinase 2 [Homo sapiens]
          Length = 917

 Score = 1368 bits (3542), Expect = 0.0
 Identities = 658/891 (73%), Positives = 775/891 (86%)

Query: 21  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80
           +D+YLY MRLSDETL++I  RFRKEM+ GL    +PTA VKMLPTFVRS PDG+E G+F+
Sbjct: 22  VDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFL 81

Query: 81  ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 140
           ALDLGG++FR+L V+V     Q V ME+++Y  PE+I+ GSG+QLFDH+AECL +FM+K 
Sbjct: 82  ALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKL 141

Query: 141 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 200
           +IKDKKLP+GFTFSFPC Q+K+DE+ L++WTK FK+SGVEG DVV L+ KAI++RGD+D 
Sbjct: 142 QIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDI 201

Query: 201 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 260
           +IVAVVNDTVGTMMTCGYDD +CE+GLI+GTG+NACYMEE+RHID+VEGDEGRMCIN EW
Sbjct: 202 DIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEW 261

Query: 261 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 320
           GAFGDDGSL DIRTEFD+EID GSLNPGKQLFEKM+SGMY+GELVRLILVKMAKE LLF 
Sbjct: 262 GAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFG 321

Query: 321 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 380
           G+++PELL  G+F T D+S IE  K+G+  A+E+L RLG++P+ +DCV+   +C IVS R
Sbjct: 322 GKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTR 381

Query: 381 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 440
           SA+L AATL A+L R+++NKG  RLR+T+GVDGS+YK HP +++R HKT+RRLVP  DVR
Sbjct: 382 SASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVR 441

Query: 441 FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK 500
           FL SE GSGKGAAMVTAVAYRLA+QHR  ++TL H  L+ D LLEVK+RM+ EME GL K
Sbjct: 442 FLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSK 501

Query: 501 QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA 560
           +TH +A VKMLP++V  TPDGTE GDFLALDLGGTNFRVLLV++R+GK   VEMHNKIYA
Sbjct: 502 ETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYA 561

Query: 561 IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK 620
           IP E+M GTG+ELFDHIV CI+DFL+YMG+KG  +PLGFTFSFPCQQ SLD  IL+ WTK
Sbjct: 562 IPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTK 621

Query: 621 GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG 680
           GFKA+ C G DVVTLL++AI RREEFDLDVVAVVNDTVGTMMTC +E+P CEVGLIVGTG
Sbjct: 622 GFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTG 681

Query: 681 SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY 740
           SNACYMEEM+NVE+VEG++G+MC+NMEWGAFGDNGCLDD RT +D  VDE SLN GKQR+
Sbjct: 682 SNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRF 741

Query: 741 EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR 800
           EKMISGMYLGEIVRNILIDFTK+G LFRG+ISE LKTRGIFETKFLSQIESD LALLQVR
Sbjct: 742 EKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVR 801

Query: 801 AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 860
           AILQ LGL STCDDSI+VK VC VV+RRAAQLCGAGMAAVVD+IRENRGLD L VTVGVD
Sbjct: 802 AILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVD 861

Query: 861 GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLR 911
           GTLYKLHPHF+++MH+TVK+L+PKC+VSFL SEDGSGKGAALITAV  R+R
Sbjct: 862 GTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIR 912



 Score =  546 bits (1406), Expect = e-155
 Identities = 258/447 (57%), Positives = 344/447 (76%)

Query: 464 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 523
           +Q +++++ L H  L+ + LLE+ KR R EME GL   TH  A VKMLP+FVR TPDGTE
Sbjct: 17  DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 76

Query: 524 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 583
           +G+FLALDLGGTNFRVL VK+     + VEM N+IYAIP +IM+G+G +LFDHI  C+++
Sbjct: 77  HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN 136

Query: 584 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 643
           F+D + IK  ++PLGFTFSFPC QT LD   L++WTKGFK++   G DVV L+R AI+RR
Sbjct: 137 FMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRR 196

Query: 644 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 703
            +FD+D+VAVVNDTVGTMMTC Y++  CE+GLIVGTGSNACYMEEM++++MVEGD+G+MC
Sbjct: 197 GDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMC 256

Query: 704 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 763
           INMEWGAFGD+G L+DIRT +D+ +D  SLN GKQ +EKMISGMY+GE+VR IL+   K+
Sbjct: 257 INMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKE 316

Query: 764 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 823
             LF G++S  L   G FETK +S IE ++  + + R +L +LGL+ T +D +    +C 
Sbjct: 317 ELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQ 376

Query: 824 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 883
           +VS R+A LC A +AAV+ +I+EN+G +RL  T+GVDG++YK HPHF++ +H+TV+ L P
Sbjct: 377 IVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP 436

Query: 884 KCNVSFLLSEDGSGKGAALITAVGVRL 910
            C+V FL SEDGSGKGAA++TAV  RL
Sbjct: 437 GCDVRFLRSEDGSGKGAAMVTAVAYRL 463



 Score =  521 bits (1342), Expect = e-147
 Identities = 246/442 (55%), Positives = 336/442 (76%)

Query: 23  KYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIAL 82
           K L  ++LS + L+++  R + EM+ GLS++ + +A VKMLPT+V + PDG+EKGDF+AL
Sbjct: 472 KTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLAL 531

Query: 83  DLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKI 142
           DLGG++FR+L V+V + K   V M +++Y  P+ ++HG+G +LFDH+ +C+ DF+E   +
Sbjct: 532 DLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGM 591

Query: 143 KDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANI 202
           K   LP+GFTFSFPCQQ+ +DE+IL+ WTK FKASG EG DVV LL +AI +R ++D ++
Sbjct: 592 KGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDV 651

Query: 203 VAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGA 262
           VAVVNDTVGTMMTCG++D HCEVGLI+GTG+NACYMEE+R+++LVEG+EGRMC+N EWGA
Sbjct: 652 VAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGA 711

Query: 263 FGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGR 322
           FGD+G L+D RTEFD  +D  SLNPGKQ FEKM+SGMYLGE+VR IL+   K GLLF GR
Sbjct: 712 FGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGR 771

Query: 323 ITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSA 382
           I+  L TRG F T  +S IE +   L   + IL  LG+E + DD + V+ VCT+V+ R+A
Sbjct: 772 ISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAA 831

Query: 383 NLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFL 442
            L  A + A+++R+R+N+G   L+ TVGVDG+LYK HP +++  H+T++ L P  DV FL
Sbjct: 832 QLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFL 891

Query: 443 LSESGSGKGAAMVTAVAYRLAE 464
            SE GSGKGAA++TAVA R+ E
Sbjct: 892 QSEDGSGKGAALITAVACRIRE 913


>gi|156151420 hexokinase domain containing 1 [Homo sapiens]
          Length = 917

 Score = 1323 bits (3424), Expect = 0.0
 Identities = 639/891 (71%), Positives = 764/891 (85%), Gaps = 1/891 (0%)

Query: 21  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80
           +D++LY MRLSD+TL+DIM RFR EM+ GL++D NPTA VKMLPTFVR+IPDGSE G+F+
Sbjct: 22  VDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSENGEFL 81

Query: 81  ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 140
           +LDLGGS FR+L+VQV  E  ++V MES+ Y TP  I+ G+G++LF++VA+CL DFM+ +
Sbjct: 82  SLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLADFMKTK 141

Query: 141 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 200
            +K KKLP+G TFSFPC+Q+K++E +L++WTK+FKA GV+  DVV  L KA+++  D D 
Sbjct: 142 DLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRHKDMDV 201

Query: 201 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 260
           +I+A+VNDTVGTMMTC YDD +CEVG+IIGTGTNACYME++ +IDLVEGDEGRMCINTEW
Sbjct: 202 DILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINTEW 261

Query: 261 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 320
           GAFGDDG+LEDIRTEFDRE+D GSLNPGKQLFEKM+SG+YLGELVRLIL+KMAK GLLF 
Sbjct: 262 GAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKAGLLFG 321

Query: 321 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 380
           G  +  L T+GK  T  V+A+EK KEGL N +EIL  LG+EPS+ DC++VQHVCTIVSFR
Sbjct: 322 GEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCTIVSFR 381

Query: 381 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 440
           SANL AA L AIL RLR+NK   RLRTTVG+DG+LYK HPQY +R HK +R+LVP  DVR
Sbjct: 382 SANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVPSCDVR 441

Query: 441 FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK 500
           FLLSESGS KGAAMVTAVA R+  Q +QI+  LA F LT++ L++V+ +MRAE+E GL+K
Sbjct: 442 FLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLKK 501

Query: 501 QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA 560
           ++H  A V+MLP++V   PDGTE G FLALDLGGTNFRVLLVKIRSG +R+V M+NKI+A
Sbjct: 502 KSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRVLLVKIRSG-RRSVRMYNKIFA 560

Query: 561 IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK 620
           IP+EIMQGTGEELFDHIV CI+DFLDYMG+KG  +PLGFTFSFPC+Q S+D G LI WTK
Sbjct: 561 IPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTK 620

Query: 621 GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG 680
           GFKATDC G DVV +LR+AIKRR EFDLD+VAVVNDTVGTMMTC YE+P CE+GLI GTG
Sbjct: 621 GFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTG 680

Query: 681 SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY 740
           SN CYME+M+N+EMVEG +G+MCIN EWG FGDNGC+DDIRT YD  VDE SLN GKQRY
Sbjct: 681 SNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDIRTRYDTEVDEGSLNPGKQRY 740

Query: 741 EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR 800
           EKM SGMYLGEIVR ILID TK+G LFRGQISE L+TRGIFETKFLSQIESDRLALLQVR
Sbjct: 741 EKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQVR 800

Query: 801 AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 860
            ILQQLGL+STC+DSI+VK VCG VSRRAAQLCGAG+AA+V+K RE++GL+ L +TVGVD
Sbjct: 801 RILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLRITVGVD 860

Query: 861 GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLR 911
           GTLYKLHPHFSRI+ +TVKEL+P+C+V+F+LSEDGSGKGAALITAV  RL+
Sbjct: 861 GTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGAALITAVAKRLQ 911



 Score =  498 bits (1282), Expect = e-140
 Identities = 235/450 (52%), Positives = 332/450 (73%)

Query: 464 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 523
           +Q ++++  L H  L+ D LL++ +R RAEME GL K T+  A VKMLP+FVR  PDG+E
Sbjct: 17  DQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSE 76

Query: 524 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 583
           NG+FL+LDLGG+ FRVL V++    KR V+M ++ Y  P EI++G G ELF+++  C++D
Sbjct: 77  NGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLAD 136

Query: 584 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 643
           F+    +K  ++PLG TFSFPC+QT L+ G+L++WTK FKA      DVV+ L  A++R 
Sbjct: 137 FMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRH 196

Query: 644 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 703
           ++ D+D++A+VNDTVGTMMTCAY++P CEVG+I+GTG+NACYME+M N+++VEGD+G+MC
Sbjct: 197 KDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMC 256

Query: 704 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 763
           IN EWGAFGD+G L+DIRT +DR +D  SLN GKQ +EKMISG+YLGE+VR IL+   K 
Sbjct: 257 INTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKA 316

Query: 764 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 823
           G LF G+ S  L T+G  ET+ ++ +E  +  L   R IL  LGL  +  D I V+ VC 
Sbjct: 317 GLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCT 376

Query: 824 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 883
           +VS R+A LC A +AA++ ++REN+ ++RL  TVG+DGTLYK+HP + + +H+ V++L P
Sbjct: 377 IVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVP 436

Query: 884 KCNVSFLLSEDGSGKGAALITAVGVRLRTE 913
            C+V FLLSE GS KGAA++TAV  R++ +
Sbjct: 437 SCDVRFLLSESGSTKGAAMVTAVASRVQAQ 466



 Score =  493 bits (1270), Expect = e-139
 Identities = 234/448 (52%), Positives = 330/448 (73%), Gaps = 1/448 (0%)

Query: 21  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80
           ID+ L   +L+ E L+D+  + R E++ GL +  +  ATV+MLPT+V  +PDG+EKG F+
Sbjct: 470 IDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFL 529

Query: 81  ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 140
           ALDLGG++FR+L V++   + ++V M ++++  P  I+ G+G +LFDH+ +C+ DF++  
Sbjct: 530 ALDLGGTNFRVLLVKIRSGR-RSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYM 588

Query: 141 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 200
            +K   LP+GFTFSFPC+Q  ID+  LI WTK FKA+  EG DVV +L +AIK+R ++D 
Sbjct: 589 GLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDL 648

Query: 201 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 260
           +IVAVVNDTVGTMMTCGY+D +CE+GLI GTG+N CYME++R+I++VEG EG+MCINTEW
Sbjct: 649 DIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEW 708

Query: 261 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 320
           G FGD+G ++DIRT +D E+D GSLNPGKQ +EKM SGMYLGE+VR IL+ + K+GLLF 
Sbjct: 709 GGFGDNGCIDDIRTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFR 768

Query: 321 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 380
           G+I+  L TRG F T  +S IE ++  L   + IL +LG++ + +D + V+ VC  VS R
Sbjct: 769 GQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRR 828

Query: 381 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 440
           +A L  A L AI+ + R+++G   LR TVGVDG+LYK HP +SR   +T++ L P  DV 
Sbjct: 829 AAQLCGAGLAAIVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVT 888

Query: 441 FLLSESGSGKGAAMVTAVAYRLAEQHRQ 468
           F+LSE GSGKGAA++TAVA RL +  ++
Sbjct: 889 FMLSEDGSGKGAALITAVAKRLQQAQKE 916


>gi|194097330 hexokinase 3 [Homo sapiens]
          Length = 923

 Score =  944 bits (2440), Expect = 0.0
 Identities = 478/892 (53%), Positives = 629/892 (70%), Gaps = 9/892 (1%)

Query: 21  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80
           + + L   +++   L  I       M+  L    +P   V+MLPT+V S P G+E+GDF+
Sbjct: 33  VQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTEQGDFV 92

Query: 81  ALDLG--GSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 138
            L+LG  G+S R+L V +   +   V   S+ +  P+ ++ G+G QLFD  A CL +F++
Sbjct: 93  VLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIPQEVMLGAGQQLFDFAAHCLSEFLD 152

Query: 139 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 198
            + +  + L +GF+FSFPC Q+ +D + LI+WTK F+ SGVEG DVV+LL  AI+++G Y
Sbjct: 153 AQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIRRQGAY 212

Query: 199 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 258
           + ++VAVVNDTVGTMM C    + CEVGL++ TGTNACYMEE RH+ +++ D GR+C++ 
Sbjct: 213 NIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGRVCVSV 272

Query: 259 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 318
           EWG+F DDG+L  + T FD  +D  SLNPG Q FEKM+ G+YLGELVRL+L  +A+ G+L
Sbjct: 273 EWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLARCGVL 332

Query: 319 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 378
           F G  +P LL++G      V+ +E    G      IL  LG+ P   D   VQHVC  V 
Sbjct: 333 FGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQHVCAAVC 392

Query: 379 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 438
            R+A L AA L A+L+ L+ ++    L+  V   G + + HP++      T+  L P+ D
Sbjct: 393 TRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLLAPECD 452

Query: 439 VRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGL 498
           V  + S  G G+G AMVTAVA RLA   R +EETLA F L  D L  V+ +MR  M  GL
Sbjct: 453 VSLIPSVDGGGRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGL 512

Query: 499 RKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKI 558
           R +  +   ++MLP+FVR TPDG+E GDFLALDLGGTNFRVLLV++ +G    V++ ++I
Sbjct: 513 RGEASS---LRMLPTFVRATPDGSERGDFLALDLGGTNFRVLLVRVTTG----VQITSEI 565

Query: 559 YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITW 618
           Y+IP  + QG+G++LFDHIV CI DF    G+ G  +PLGFTFSFPC+Q  LD GIL+ W
Sbjct: 566 YSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNW 625

Query: 619 TKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVG 678
           TKGFKA+DC G DVV+LLR+AI RR+  +L+VVA+VNDTVGTMM+C YE+P CE+GLIVG
Sbjct: 626 TKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVG 685

Query: 679 TGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQ 738
           TG+NACYMEE++NV  V GD G+MCINMEWGAFGD+G L  + T +D  VD+ S+N GKQ
Sbjct: 686 TGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGDDGSLAMLSTRFDASVDQASINPGKQ 745

Query: 739 RYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQ 798
           R+EKMISGMYLGEIVR+IL+  T  G LFRGQ  + L+TR IF+TKFLS+IESD LAL Q
Sbjct: 746 RFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQ 805

Query: 799 VRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVG 858
           VRAIL+ LGL  T DD+++V  VC  VS+RAAQLCGAG+AAVV+KIRENRGL+ L V+VG
Sbjct: 806 VRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEELAVSVG 865

Query: 859 VDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRL 910
           VDGTLYKLHP FS ++  TV+EL+P+C V+FL SEDGSGKGAAL+TAV  RL
Sbjct: 866 VDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSEDGSGKGAALVTAVACRL 917



 Score =  463 bits (1192), Expect = e-130
 Identities = 232/447 (51%), Positives = 308/447 (68%), Gaps = 7/447 (1%)

Query: 21  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80
           +++ L   RL+ + L  +  + RK M  GL  +    ++++MLPTFVR+ PDGSE+GDF+
Sbjct: 483 LEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGE---ASSLRMLPTFVRATPDGSERGDFL 539

Query: 81  ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 140
           ALDLGG++FR+L V+V       V + SE+Y  PE +  GSG QLFDH+ +C+ DF +K+
Sbjct: 540 ALDLGGTNFRVLLVRVT----TGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQ 595

Query: 141 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 200
            +  + LP+GFTFSFPC+Q  +D+ IL+ WTK FKAS  EG DVV LL +AI +R   + 
Sbjct: 596 GLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVEL 655

Query: 201 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 260
           N+VA+VNDTVGTMM+CGY+D  CE+GLI+GTGTNACYMEELR++  V GD GRMCIN EW
Sbjct: 656 NVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEW 715

Query: 261 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 320
           GAFGDDGSL  + T FD  +D+ S+NPGKQ FEKM+SGMYLGE+VR IL+ +   G+LF 
Sbjct: 716 GAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFR 775

Query: 321 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 380
           G+    L TR  F T  +S IE +   L   + IL  LG+  + DD + V  VC  VS R
Sbjct: 776 GQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQR 835

Query: 381 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 440
           +A L  A + A++ ++R+N+G   L  +VGVDG+LYK HP++S     T+R L P   V 
Sbjct: 836 AAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVT 895

Query: 441 FLLSESGSGKGAAMVTAVAYRLAEQHR 467
           FL SE GSGKGAA+VTAVA RLA+  R
Sbjct: 896 FLQSEDGSGKGAALVTAVACRLAQLTR 922


>gi|15967161 glucokinase isoform 3 [Homo sapiens]
          Length = 464

 Score =  506 bits (1304), Expect = e-143
 Identities = 245/451 (54%), Positives = 336/451 (74%), Gaps = 2/451 (0%)

Query: 461 RLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPD 520
           +L + + Q+E+ LA F L ++ L +V +RM+ EM+ GLR +TH  A VKMLP++VR TP+
Sbjct: 7   QLPQPNSQVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPE 66

Query: 521 GTENGDFLALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIV 578
           G+E GDFL+LDLGGTNFRV+LVK+  G++   +V+  +++Y+IP + M GT E LFD+I 
Sbjct: 67  GSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYIS 126

Query: 579 SCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRD 638
            CISDFLD   +K  ++PLGFTFSFP +   +D GIL+ WTKGFKA+   G++VV LLRD
Sbjct: 127 ECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRD 186

Query: 639 AIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGD 698
           AIKRR +F++DVVA+VNDTV TM++C YE+  CEVG+IVGTG NACYMEEM+NVE+VEGD
Sbjct: 187 AIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGD 246

Query: 699 QGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILI 758
           +G+MC+N EWGAFGD+G LD+    YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+
Sbjct: 247 EGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLL 306

Query: 759 DFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILV 818
               +  LF G+ SE L+TRG FET+F+SQ+ESD     Q+  IL  LGL  +  D  +V
Sbjct: 307 RLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIV 366

Query: 819 KTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTV 878
           +  C  VS RAA +C AG+A V++++RE+R  D + +TVGVDG++YKLHP F    H +V
Sbjct: 367 RRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASV 426

Query: 879 KELSPKCNVSFLLSEDGSGKGAALITAVGVR 909
           + L+P C ++F+ SE+GSG+GAAL++AV  +
Sbjct: 427 RRLTPSCEITFIESEEGSGRGAALVSAVACK 457



 Score =  474 bits (1219), Expect = e-133
 Identities = 222/445 (49%), Positives = 320/445 (71%), Gaps = 2/445 (0%)

Query: 21  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80
           +++ L   +L +E L  +M R +KEM  GL  + +  A+VKMLPT+VRS P+GSE GDF+
Sbjct: 15  VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 74

Query: 81  ALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 138
           +LDLGG++FR++ V+V    E   +V  + ++Y  PE+ + G+   LFD+++EC+ DF++
Sbjct: 75  SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 134

Query: 139 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 198
           K ++K KKLP+GFTFSFP +   ID+ IL+ WTK FKASG EG +VV LL  AIK+RGD+
Sbjct: 135 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 194

Query: 199 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 258
           + ++VA+VNDTV TM++C Y+D  CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+NT
Sbjct: 195 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 254

Query: 259 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 318
           EWGAFGD G L++   E+DR +D  S NPG+QL+EK++ G Y+GELVRL+L+++  E LL
Sbjct: 255 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 314

Query: 319 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 378
           F G  + +L TRG F T  VS +E +         IL+ LG+ PS  DC  V+  C  VS
Sbjct: 315 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 374

Query: 379 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 438
            R+A++ +A L  ++NR+R+++    +R TVGVDGS+YK HP +  RFH ++RRL P  +
Sbjct: 375 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 434

Query: 439 VRFLLSESGSGKGAAMVTAVAYRLA 463
           + F+ SE GSG+GAA+V+AVA + A
Sbjct: 435 ITFIESEEGSGRGAALVSAVACKKA 459


>gi|4503951 glucokinase isoform 1 [Homo sapiens]
          Length = 465

 Score =  504 bits (1298), Expect = e-142
 Identities = 244/449 (54%), Positives = 334/449 (74%), Gaps = 2/449 (0%)

Query: 463 AEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGT 522
           A +  ++E+ LA F L ++ L +V +RM+ EM+ GLR +TH  A VKMLP++VR TP+G+
Sbjct: 10  AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69

Query: 523 ENGDFLALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIVSC 580
           E GDFL+LDLGGTNFRV+LVK+  G++   +V+  +++Y+IP + M GT E LFD+I  C
Sbjct: 70  EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129

Query: 581 ISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAI 640
           ISDFLD   +K  ++PLGFTFSFP +   +D GIL+ WTKGFKA+   G++VV LLRDAI
Sbjct: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189

Query: 641 KRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQG 700
           KRR +F++DVVA+VNDTV TM++C YE+  CEVG+IVGTG NACYMEEM+NVE+VEGD+G
Sbjct: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249

Query: 701 QMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDF 760
           +MC+N EWGAFGD+G LD+    YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+  
Sbjct: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309

Query: 761 TKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKT 820
             +  LF G+ SE L+TRG FET+F+SQ+ESD     Q+  IL  LGL  +  D  +V+ 
Sbjct: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369

Query: 821 VCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKE 880
            C  VS RAA +C AG+A V++++RE+R  D + +TVGVDG++YKLHP F    H +V+ 
Sbjct: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429

Query: 881 LSPKCNVSFLLSEDGSGKGAALITAVGVR 909
           L+P C ++F+ SE+GSG+GAAL++AV  +
Sbjct: 430 LTPSCEITFIESEEGSGRGAALVSAVACK 458



 Score =  474 bits (1219), Expect = e-133
 Identities = 222/445 (49%), Positives = 320/445 (71%), Gaps = 2/445 (0%)

Query: 21  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80
           +++ L   +L +E L  +M R +KEM  GL  + +  A+VKMLPT+VRS P+GSE GDF+
Sbjct: 16  VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 75

Query: 81  ALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 138
           +LDLGG++FR++ V+V    E   +V  + ++Y  PE+ + G+   LFD+++EC+ DF++
Sbjct: 76  SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 135

Query: 139 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 198
           K ++K KKLP+GFTFSFP +   ID+ IL+ WTK FKASG EG +VV LL  AIK+RGD+
Sbjct: 136 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 195

Query: 199 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 258
           + ++VA+VNDTV TM++C Y+D  CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+NT
Sbjct: 196 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 255

Query: 259 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 318
           EWGAFGD G L++   E+DR +D  S NPG+QL+EK++ G Y+GELVRL+L+++  E LL
Sbjct: 256 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 315

Query: 319 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 378
           F G  + +L TRG F T  VS +E +         IL+ LG+ PS  DC  V+  C  VS
Sbjct: 316 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 375

Query: 379 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 438
            R+A++ +A L  ++NR+R+++    +R TVGVDGS+YK HP +  RFH ++RRL P  +
Sbjct: 376 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 435

Query: 439 VRFLLSESGSGKGAAMVTAVAYRLA 463
           + F+ SE GSG+GAA+V+AVA + A
Sbjct: 436 ITFIESEEGSGRGAALVSAVACKKA 460


>gi|15967159 glucokinase isoform 2 [Homo sapiens]
          Length = 466

 Score =  503 bits (1294), Expect = e-142
 Identities = 243/443 (54%), Positives = 331/443 (74%), Gaps = 2/443 (0%)

Query: 469 IEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFL 528
           +E+ LA F L ++ L +V +RM+ EM+ GLR +TH  A VKMLP++VR TP+G+E GDFL
Sbjct: 17  VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76

Query: 529 ALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLD 586
           +LDLGGTNFRV+LVK+  G++   +V+  +++Y+IP + M GT E LFD+I  CISDFLD
Sbjct: 77  SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136

Query: 587 YMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEF 646
              +K  ++PLGFTFSFP +   +D GIL+ WTKGFKA+   G++VV LLRDAIKRR +F
Sbjct: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196

Query: 647 DLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINM 706
           ++DVVA+VNDTV TM++C YE+  CEVG+IVGTG NACYMEEM+NVE+VEGD+G+MC+N 
Sbjct: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256

Query: 707 EWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFL 766
           EWGAFGD+G LD+    YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+    +  L
Sbjct: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316

Query: 767 FRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVS 826
           F G+ SE L+TRG FET+F+SQ+ESD     Q+  IL  LGL  +  D  +V+  C  VS
Sbjct: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376

Query: 827 RRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCN 886
            RAA +C AG+A V++++RE+R  D + +TVGVDG++YKLHP F    H +V+ L+P C 
Sbjct: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436

Query: 887 VSFLLSEDGSGKGAALITAVGVR 909
           ++F+ SE+GSG+GAAL++AV  +
Sbjct: 437 ITFIESEEGSGRGAALVSAVACK 459



 Score =  474 bits (1219), Expect = e-133
 Identities = 222/445 (49%), Positives = 320/445 (71%), Gaps = 2/445 (0%)

Query: 21  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80
           +++ L   +L +E L  +M R +KEM  GL  + +  A+VKMLPT+VRS P+GSE GDF+
Sbjct: 17  VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76

Query: 81  ALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 138
           +LDLGG++FR++ V+V    E   +V  + ++Y  PE+ + G+   LFD+++EC+ DF++
Sbjct: 77  SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136

Query: 139 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 198
           K ++K KKLP+GFTFSFP +   ID+ IL+ WTK FKASG EG +VV LL  AIK+RGD+
Sbjct: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196

Query: 199 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 258
           + ++VA+VNDTV TM++C Y+D  CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+NT
Sbjct: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256

Query: 259 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 318
           EWGAFGD G L++   E+DR +D  S NPG+QL+EK++ G Y+GELVRL+L+++  E LL
Sbjct: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316

Query: 319 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 378
           F G  + +L TRG F T  VS +E +         IL+ LG+ PS  DC  V+  C  VS
Sbjct: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376

Query: 379 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 438
            R+A++ +A L  ++NR+R+++    +R TVGVDGS+YK HP +  RFH ++RRL P  +
Sbjct: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436

Query: 439 VRFLLSESGSGKGAAMVTAVAYRLA 463
           + F+ SE GSG+GAA+V+AVA + A
Sbjct: 437 ITFIESEEGSGRGAALVSAVACKKA 461


>gi|164663810 ribosomal modification protein rimK-like family member
           A [Homo sapiens]
          Length = 391

 Score = 34.7 bits (78), Expect = 0.42
 Identities = 33/143 (23%), Positives = 59/143 (41%), Gaps = 30/143 (20%)

Query: 577 IVSCISDFLDYMGIKGPRMPLGFTFSFPCQQT---------SLDAGILITWTKG------ 621
           I++CI+ F  +  + G  +P+  TFS+   +           L   +++  T+G      
Sbjct: 105 ILNCINKFWTFQELAGHGVPMPDTFSYGGHEDFSKMIDEAEPLGYPVVVKSTRGHRGKAV 164

Query: 622 FKATD---------CVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYE---EP 669
           F A D          + HDV  L +  +K     D+ VV V    +G+M+ C+ +   + 
Sbjct: 165 FLARDKHHLSDICHLIRHDVPYLFQKYVKESHGKDIRVVVVGGQVIGSMLRCSTDGRMQS 224

Query: 670 TCEVGLIVGTGSNACYMEEMKNV 692
            C +G   G G      E+ K +
Sbjct: 225 NCSLG---GVGVKCPLTEQGKQL 244


>gi|134254462 ribosomal modification protein rimK-like family member
           B [Homo sapiens]
          Length = 386

 Score = 33.5 bits (75), Expect = 0.93
 Identities = 41/191 (21%), Positives = 75/191 (39%), Gaps = 51/191 (26%)

Query: 577 IVSCISDFLDYMGIKGPRMPLGFTFSFPCQQT---------SLDAGILITWTKG------ 621
           I++C++ F  +  + G  +PL  TFS+   +           L+  +++  T+G      
Sbjct: 109 ILNCVNKFWTFQELAGHGVPLPDTFSYGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAV 168

Query: 622 FKATD---------CVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYE---EP 669
           F A D          + H+   L +  +K     D+ V+ V    VGTM+ C+ +   + 
Sbjct: 169 FLARDKHHLADLSHLIRHEAPYLFQKYVKESHGRDVRVIVVGGRVVGTMLRCSTDGRMQS 228

Query: 670 TCEVGLIVGTGSNACYMEEMK---------------NVEMVEGDQGQMCI-----NMEWG 709
            C +G   G G      E+ K                ++++  D G  C+     N+ + 
Sbjct: 229 NCSLG---GVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFI 285

Query: 710 AFGDNGCLDDI 720
           AF D  C  D+
Sbjct: 286 AF-DKACNLDV 295


>gi|21389509 KPL2 protein isoform 2 [Homo sapiens]
          Length = 514

 Score = 32.0 bits (71), Expect = 2.7
 Identities = 17/76 (22%), Positives = 37/76 (48%), Gaps = 2/76 (2%)

Query: 458 VAYRLAEQHRQIEETLAHFHLTK-DMLLEVKKRMRA-EMELGLRKQTHNNAVVKMLPSFV 515
           + YR  E+++ ++E LAH H  K +   ++K+  R  ++E     +   N ++  + + +
Sbjct: 155 ITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAI 214

Query: 516 RRTPDGTENGDFLALD 531
            + P    N    AL+
Sbjct: 215 IQIPKPASNRTLKALE 230


>gi|145699133 KPL2 protein isoform 1 [Homo sapiens]
          Length = 1822

 Score = 32.0 bits (71), Expect = 2.7
 Identities = 17/76 (22%), Positives = 37/76 (48%), Gaps = 2/76 (2%)

Query: 458 VAYRLAEQHRQIEETLAHFHLTK-DMLLEVKKRMRA-EMELGLRKQTHNNAVVKMLPSFV 515
           + YR  E+++ ++E LAH H  K +   ++K+  R  ++E     +   N ++  + + +
Sbjct: 155 ITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAI 214

Query: 516 RRTPDGTENGDFLALD 531
            + P    N    AL+
Sbjct: 215 IQIPKPASNRTLKALE 230


>gi|42415492 chromosome 14 open reading frame 106 [Homo sapiens]
          Length = 1132

 Score = 30.4 bits (67), Expect = 7.9
 Identities = 23/77 (29%), Positives = 37/77 (48%), Gaps = 4/77 (5%)

Query: 276 FDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMA--KEGLLFEGRITPELLTRGKF 333
           F   I  G+L P K L +   S + L +  +   +KM       +F+  +  E  T    
Sbjct: 30  FFDSIPSGTLTPVKDLVKYQNSSLKLNDHKKNQFLKMTTFNNKNIFQSTMLTEATTSN-- 87

Query: 334 NTSDVSAIEKNKEGLHN 350
           ++ D+SAI+ NK+GL N
Sbjct: 88  SSLDISAIKPNKDGLKN 104


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,436,444
Number of Sequences: 37866
Number of extensions: 1408811
Number of successful extensions: 2748
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2703
Number of HSP's gapped (non-prelim): 28
length of query: 916
length of database: 18,247,518
effective HSP length: 111
effective length of query: 805
effective length of database: 14,044,392
effective search space: 11305735560
effective search space used: 11305735560
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.