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Search of human proteins with 157743292
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo
sapiens]
(466 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo sap... 956 0.0
gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3... 324 1e-88
gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1... 318 7e-87
gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [H... 285 5e-77
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 279 3e-75
gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isof... 243 3e-64
gi|22208964 ankyrin repeat and SOCS box-containing protein 4 iso... 157 1e-38
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 109 6e-24
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 109 6e-24
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 109 6e-24
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 106 5e-23
gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2 [... 102 6e-22
gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1 [... 102 6e-22
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 97 2e-20
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 97 3e-20
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 97 3e-20
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 97 3e-20
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 97 3e-20
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 97 3e-20
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 96 7e-20
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 95 1e-19
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 95 1e-19
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 94 3e-19
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 94 3e-19
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 93 6e-19
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 92 1e-18
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 87 2e-17
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 87 4e-17
gi|38176283 ankyrin repeat and SOCS box-containing protein 7 iso... 85 1e-16
gi|30089994 ankyrin repeat and SOCS box-containing protein 7 iso... 85 1e-16
>gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo
sapiens]
Length = 466
Score = 956 bits (2472), Expect = 0.0
Identities = 466/466 (100%), Positives = 466/466 (100%)
Query: 1 MSNSDYLPDYPLNSDLVKRLKSALDAKDEERVRDLICTEITPVDAVIELANDDWMKDPSA 60
MSNSDYLPDYPLNSDLVKRLKSALDAKDEERVRDLICTEITPVDAVIELANDDWMKDPSA
Sbjct: 1 MSNSDYLPDYPLNSDLVKRLKSALDAKDEERVRDLICTEITPVDAVIELANDDWMKDPSA 60
Query: 61 QLPTGMLLGDLDHLKPLMDQFFQDANVVFEINKDEMEWQVKSPATFGLSGLWTLEYKREL 120
QLPTGMLLGDLDHLKPLMDQFFQDANVVFEINKDEMEWQVKSPATFGLSGLWTLEYKREL
Sbjct: 61 QLPTGMLLGDLDHLKPLMDQFFQDANVVFEINKDEMEWQVKSPATFGLSGLWTLEYKREL 120
Query: 121 TTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDL
Sbjct: 121 TTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG
Sbjct: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA
Sbjct: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGSPTV 360
CGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGSPTV
Sbjct: 301 CGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGSPTV 360
Query: 361 WPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEVFQMHKPFYQSLFALALT 420
WPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEVFQMHKPFYQSLFALALT
Sbjct: 361 WPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEVFQMHKPFYQSLFALALT 420
Query: 421 PRCLQHLCRCALRRLFGKRCFDLIPLLPLPKPLQNYLLLEPQGVLH 466
PRCLQHLCRCALRRLFGKRCFDLIPLLPLPKPLQNYLLLEPQGVLH
Sbjct: 421 PRCLQHLCRCALRRLFGKRCFDLIPLLPLPKPLQNYLLLEPQGVLH 466
>gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3
[Homo sapiens]
Length = 452
Score = 324 bits (830), Expect = 1e-88
Identities = 188/410 (45%), Positives = 235/410 (57%), Gaps = 12/410 (2%)
Query: 62 LPTGMLLGDLDHLKPLMDQFFQDANVVFEINKDEMEWQVKSPATFGLSGLWTLEYKRELT 121
L + GDL L+ L A+++ E E W GLW+L Y+ ELT
Sbjct: 50 LQNALYTGDLARLQELFPPH-STADLLLESRAAEPRWSSHQ------RGLWSLTYEEELT 102
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDLL 181
TPL +AA+ GHT +R LL R A PD++PGGR ALHEAC GHTACV +LL ADP++
Sbjct: 103 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIA 162
Query: 182 SAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGR 241
+G PLHLCR +L CA+ LL GA V +TPLHVAA+ G E A L L R
Sbjct: 163 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR 222
Query: 242 GAHVDARNGRGETALSAACGAARRPDEHG-----RCLRLCALLLRRGAEADARDEDERSP 296
GA DARN G T L AAC + RCL+LC+LLL GA+ADA D+D++ P
Sbjct: 223 GACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRP 282
Query: 297 LHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHG 356
LH AC ++ LLL G A +DYGG +PL LQ + AL SP+ V+ALLNHG
Sbjct: 283 LHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHG 342
Query: 357 SPTVWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEVFQMHKPFYQSLFA 416
+ VWP A PKVL+ ++ P IEVL N+Y + L E ++ E Q H+ FY SLFA
Sbjct: 343 AVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFA 402
Query: 417 LALTPRCLQHLCRCALRRLFGKRCFDLIPLLPLPKPLQNYLLLEPQGVLH 466
L PR LQHL RCALR +P LPLP L YL L+ +GVL+
Sbjct: 403 LVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 452
>gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1
[Homo sapiens]
Length = 512
Score = 318 bits (815), Expect = 7e-87
Identities = 177/361 (49%), Positives = 219/361 (60%), Gaps = 5/361 (1%)
Query: 111 LWTLEYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRL 170
LW+L Y+ ELTTPL +AA+ GHT +R LL R A PD++PGGR ALHEAC GHTACV +
Sbjct: 152 LWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHV 211
Query: 171 LLQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRG 230
LL ADP++ +G PLHLCR +L CA+ LL GA V +TPLHVAA+ G
Sbjct: 212 LLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLG 271
Query: 231 LDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHG-----RCLRLCALLLRRGAE 285
E A L L RGA DARN G T L AAC + RCL+LC+LLL GA+
Sbjct: 272 HVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 331
Query: 286 ADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASP 345
ADA D+D++ PLH AC ++ LLL G A +DYGG +PL LQ + AL SP
Sbjct: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391
Query: 346 QRTVQALLNHGSPTVWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEVFQ 405
+ V+ALLNHG+ VWP A PKVL+ ++ P IEVL N+Y + L E ++ E Q
Sbjct: 392 EHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQ 451
Query: 406 MHKPFYQSLFALALTPRCLQHLCRCALRRLFGKRCFDLIPLLPLPKPLQNYLLLEPQGVL 465
H+ FY SLFAL PR LQHL RCALR +P LPLP L YL L+ +GVL
Sbjct: 452 KHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVL 511
Query: 466 H 466
+
Sbjct: 512 Y 512
>gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [Homo
sapiens]
Length = 453
Score = 285 bits (730), Expect = 5e-77
Identities = 167/413 (40%), Positives = 225/413 (54%), Gaps = 20/413 (4%)
Query: 56 KDPSAQLPTGMLLGDLDHLKPLMDQFFQD---ANVVFEINKDEMEWQVKSPATFGLSGLW 112
+DP+ + G+L ++ L FQD AN++ E +++ W + G W
Sbjct: 57 RDPAVH--QALFSGNLQQVQAL----FQDEEAANMIVETVSNQLAWSAEQ-------GFW 103
Query: 113 TLEYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLL 172
L K + T PL IA A G+T C RHL+ +GA+ DA GGR ALHEAC CVRLLL
Sbjct: 104 VLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLL 163
Query: 173 QHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLD 232
A ++L+ EG PLHLC SL CA+ LLE GA+V G ++TPLHVAA RGL+
Sbjct: 164 TFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLE 223
Query: 233 EHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDED 292
+H LYL GA V R +GETAL+ AC A P R LL GA+A A
Sbjct: 224 QHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRK 283
Query: 293 ERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQAL 352
+PLH AC + LA LLLR+GA A + G +P+ LQ + P+ AL
Sbjct: 284 RHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAAL 343
Query: 353 LNHGSPTVWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEVFQMHKPFYQ 412
L++G+ V P+ +LK CA+ P +EVL N+YP + E+W E + E+++ H+ FY
Sbjct: 344 LDYGAQPVRPE----MLKHCANFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYS 399
Query: 413 SLFALALTPRCLQHLCRCALRRLFGKRCFDLIPLLPLPKPLQNYLLLEPQGVL 465
S + PR LQHL R A+R G RC LPLP L++YLLL +G +
Sbjct: 400 SALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPLLRDYLLLRVEGCI 452
>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
[Homo sapiens]
Length = 474
Score = 279 bits (714), Expect = 3e-75
Identities = 164/361 (45%), Positives = 198/361 (54%), Gaps = 43/361 (11%)
Query: 111 LWTLEYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRL 170
LW+L Y+ ELTTPL +AA+ GHT +R LL R A PD++PGGR ALHEAC GHTACV +
Sbjct: 152 LWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHV 211
Query: 171 LLQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRG 230
LL ADP++ +G PLHLCR +L CA+ LL GA V +TPLHVAA+ G
Sbjct: 212 LLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLG 271
Query: 231 LDEHARLYLGRGAHVDARNGRGETALSAAC-----GAARRPDEHGRCLRLCALLLRRGAE 285
E A L L RGA DARN G T L AAC RCL+LC+LLL GA+
Sbjct: 272 HVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 331
Query: 286 ADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASP 345
ADA D+D++ PLH AC ++ LLL G A +DYGG +PL LQ + AL SP
Sbjct: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391
Query: 346 QRTVQALLNHGSPTVWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEVFQ 405
+ V+ALLNHG+ VWP A PK
Sbjct: 392 EHVVRALLNHGAVRVWPGALPK-------------------------------------- 413
Query: 406 MHKPFYQSLFALALTPRCLQHLCRCALRRLFGKRCFDLIPLLPLPKPLQNYLLLEPQGVL 465
H+ FY SLFAL PR LQHL RCALR +P LPLP L YL L+ +GVL
Sbjct: 414 KHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVL 473
Query: 466 H 466
+
Sbjct: 474 Y 474
>gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isoform
a [Homo sapiens]
Length = 426
Score = 243 bits (620), Expect = 3e-64
Identities = 146/404 (36%), Positives = 208/404 (51%), Gaps = 13/404 (3%)
Query: 70 DLDHLKPLMDQFFQDANVVFEINKDEMEWQVKSPATFGLSGLWTLEYKRELT--TPLCIA 127
D LK ++ Q D + VFE+ + M G W YK + + T L ++
Sbjct: 29 DFGKLKAILIQRQIDVDTVFEVEDENMVLASYK------QGYWLPSYKLKSSWATGLHLS 82
Query: 128 AAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDLLSAEGLA 187
GH C+ LL A + P G+ LH AC + CV++L A + S G
Sbjct: 83 VLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHT 142
Query: 188 PLHLCRTAASLGCAQALLEHGASVQ-RVGGTGRDTPLHVAAQRGLDEHARLYLGRGAHVD 246
LH C T +S+ CA+ L+ GA+V + +TPLH AA GL E Y+ GA VD
Sbjct: 143 ALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVD 202
Query: 247 ARNGRGETALSAACGAARRPDEHGRCLR---LCALLLRRGAEADARDEDERSPLHKACGH 303
+ N ET L+ A A R E +C +LL AE +ARD+D +SPLHKA +
Sbjct: 203 SVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWN 262
Query: 304 ASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGSPTVWPD 363
H L ++L GA+A +D G + + VL+ S A P+ Q LLNHG+ ++P
Sbjct: 263 CDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPP 322
Query: 364 AFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEVFQMHKPFYQSLFALAL-TPR 422
F KV++ C S P IEV+ N+Y + + W+ IP++ + + FY SLF + +PR
Sbjct: 323 QFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSPR 382
Query: 423 CLQHLCRCALRRLFGKRCFDLIPLLPLPKPLQNYLLLEPQGVLH 466
L HL RCA+RR RC IPLL LP L+ YLLLEP+G+++
Sbjct: 383 TLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGIIY 426
>gi|22208964 ankyrin repeat and SOCS box-containing protein 4
isoform b [Homo sapiens]
Length = 349
Score = 157 bits (398), Expect = 1e-38
Identities = 104/305 (34%), Positives = 147/305 (48%), Gaps = 12/305 (3%)
Query: 70 DLDHLKPLMDQFFQDANVVFEINKDEMEWQVKSPATFGLSGLWTLEYKRELT--TPLCIA 127
D LK ++ Q D + VFE+ + M G W YK + + T L ++
Sbjct: 29 DFGKLKAILIQRQIDVDTVFEVEDENMVLASYK------QGYWLPSYKLKSSWATGLHLS 82
Query: 128 AAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDLLSAEGLA 187
GH C+ LL A + P G+ LH AC + CV++L A + S G
Sbjct: 83 VLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHT 142
Query: 188 PLHLCRTAASLGCAQALLEHGASVQ-RVGGTGRDTPLHVAAQRGLDEHARLYLGRGAHVD 246
LH C T +S+ CA+ L+ GA+V + +TPLH AA GL E Y+ GA VD
Sbjct: 143 ALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVD 202
Query: 247 ARNGRGETALSAACGAARRPDEHGRCLR---LCALLLRRGAEADARDEDERSPLHKACGH 303
+ N ET L+ A A R E +C +LL AE +ARD+D +SPLHKA +
Sbjct: 203 SVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWN 262
Query: 304 ASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGSPTVWPD 363
H L ++L GA+A +D G + + VL+ S A P+ Q LLNHG+ ++P
Sbjct: 263 CDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPP 322
Query: 364 AFPKV 368
F KV
Sbjct: 323 QFHKV 327
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 109 bits (272), Expect = 6e-24
Identities = 77/210 (36%), Positives = 105/210 (50%), Gaps = 10/210 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGAD-PDASPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
+PL +AA H CV+HLL A D + ALH A GH +LLL RA+P+
Sbjct: 313 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 372
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PLH+ + + L+++GAS+Q + +G TP+HVAA G L L
Sbjct: 373 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL-TPIHVAAFMGHLNIVLLLLQ 431
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
GA D N RGETAL A A + + + LLR GA DAR +E++PLH A
Sbjct: 432 NGASPDVTNIRGETALHMAARAGQ--------VEVVRCLLRNGALVDARAREEQTPLHIA 483
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
+ +LLL+H A A G +PL
Sbjct: 484 SRLGKTEIVQLLLQHMAHPDAATTNGYTPL 513
Score = 93.6 bits (231), Expect = 3e-19
Identities = 75/210 (35%), Positives = 98/210 (46%), Gaps = 10/210 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
T L +AA G VR LL GA DA + + LH A G T V+LLLQH A PD
Sbjct: 445 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 504
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PLH+ + A LLE GA+ G TPLHVAA+ G + A+L L
Sbjct: 505 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG-FTPLHVAAKYGSLDVAKLLLQ 563
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
R A D+ G T L A H ++ LLL +GA A ++ +PLH A
Sbjct: 564 RRAAADSAGKNGLTPLHVAA--------HYDNQKVALLLLEKGASPHATAKNGYTPLHIA 615
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
+A LL +GA+ + G +PL
Sbjct: 616 AKKNQMQIASTLLNYGAETNIVTKQGVTPL 645
Score = 89.0 bits (219), Expect = 8e-18
Identities = 76/237 (32%), Positives = 108/237 (45%), Gaps = 17/237 (7%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +A+ G+T V+ LL RG DA G LH A GH V LLL+ A
Sbjct: 247 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 306
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ GL+PLH+ + C + LL+H A V V T LHVAA G +L L
Sbjct: 307 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDV-TLDYLTALHVAAHCGHYRVTKLLLD 365
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
+ A+ +AR G T L AC R +++ LL++ GA A E +P+H A
Sbjct: 366 KRANPNARALNGFTPLHIACKKNR--------IKVMELLVKYGASIQAITESGLTPIHVA 417
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGS 357
++ LLL++GA + G + L A +A V+ LL +G+
Sbjct: 418 AFMGHLNIVLLLLQNGASPDVTNIRGETAL-------HMAARAGQVEVVRCLLRNGA 467
Score = 88.2 bits (217), Expect = 1e-17
Identities = 70/237 (29%), Positives = 103/237 (43%), Gaps = 17/237 (7%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPD-ASPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA +G + LL R A D A G LH A + LLL+ A P
Sbjct: 544 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 603
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PLH+ + A LL +GA V G TPLH+A+Q G + L L
Sbjct: 604 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTLLLD 662
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
+GA++ G T+L A + + + +L + GA+ DA + +PL A
Sbjct: 663 KGANIHMSTKSGLTSLHLAAQEDK--------VNVADILTKHGADQDAHTKLGYTPLIVA 714
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGS 357
C + + + LL+ GA+ A G +PL + A Q + LL HG+
Sbjct: 715 CHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQ-------AAQQGHTHIINVLLQHGA 764
Score = 84.0 bits (206), Expect = 3e-16
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 52/272 (19%)
Query: 124 LCIAAAHGHTACVRHLLGRGADPD-ASPGGRGALHEACLGGHTACVRLLLQHRADPDLLS 182
L +AA GH V+ LLGRG+ D A+ G ALH A L G V++L++ A+ + S
Sbjct: 47 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 106
Query: 183 AEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRG 242
G PL++ + + LLE+GA+ Q TPL VA Q+G ++ + L
Sbjct: 107 QNGFTPLYMAAQENHIDVVKYLLENGAN-QSTATEDGFTPLAVALQQGHNQAVAILL--- 162
Query: 243 AHVDARNGRGETALSAACGAARRPDEHGRCLRL--------------------------- 275
+ +G+ L A AAR+ D L L
Sbjct: 163 ----ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 218
Query: 276 ---------CALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGG 326
LLL RGA D + +PLH A + ++ +LLL G A G
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278
Query: 327 ASPLGRVLQTASCALQASPQRTVQALLNHGSP 358
+PL CA ++ + V+ LL G+P
Sbjct: 279 LTPL-------HCAARSGHDQVVELLLERGAP 303
Score = 83.6 bits (205), Expect = 4e-16
Identities = 62/210 (29%), Positives = 96/210 (45%), Gaps = 10/210 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA + + LL +GA P A+ G LH A LL + A+ ++
Sbjct: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 636
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
++ +G+ PLHL LL+ GA++ +G T LH+AAQ A +
Sbjct: 637 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL-TSLHLAAQEDKVNVADILTK 695
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
GA DA G T L AC H +++ LL++GA +A+ ++ +PLH+A
Sbjct: 696 HGADQDAHTKLGYTPLIVAC--------HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 747
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
+ +LL+HGA A G + L
Sbjct: 748 AQQGHTHIINVLLQHGAKPNATTANGNTAL 777
Score = 79.3 bits (194), Expect = 7e-15
Identities = 74/241 (30%), Positives = 100/241 (41%), Gaps = 17/241 (7%)
Query: 118 RELTTPLCIAAAHGHTACVRHLLGRGADPD-ASPGGRGALHEACLGGHTACVRLLLQHRA 176
RE TPL IA+ G T V+ LL A PD A+ G LH + G +LL+ A
Sbjct: 474 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 533
Query: 177 DPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHAR 236
L + +G PLH+ SL A+ LL+ A+ G G TPLHVAA + A
Sbjct: 534 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-TPLHVAAHYDNQKVAL 592
Query: 237 LYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSP 296
L L +GA A G T L A + +++ + LL GAE + + +P
Sbjct: 593 LLLEKGASPHATAKNGYTPLHIAAKKNQ--------MQIASTLLNYGAETNIVTKQGVTP 644
Query: 297 LHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHG 356
LH A + LLL GA+ G L + A Q L HG
Sbjct: 645 LHLASQEGHTDMVTLLLDKGANIHMSTKSG-------LTSLHLAAQEDKVNVADILTKHG 697
Query: 357 S 357
+
Sbjct: 698 A 698
Score = 62.0 bits (149), Expect = 1e-09
Identities = 48/139 (34%), Positives = 65/139 (46%), Gaps = 2/139 (1%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +A+ GHT V LL +GA+ S G +LH A +L +H AD D
Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PL + ++ LL+ GA+V G TPLH AAQ+G + L
Sbjct: 703 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQAAQQGHTHIINVLLQ 761
Query: 241 RGAHVDARNGRGETALSAA 259
GA +A G TAL+ A
Sbjct: 762 HGAKPNATTANGNTALAIA 780
Score = 49.3 bits (116), Expect = 7e-06
Identities = 28/84 (33%), Positives = 43/84 (51%), Gaps = 1/84 (1%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +A +G+ V LL +GA+ +A + G LH+A GHT + +LLQH A P+
Sbjct: 709 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 768
Query: 181 LSAEGLAPLHLCRTAASLGCAQAL 204
+A G L + + + L
Sbjct: 769 TTANGNTALAIAKRLGYISVVDTL 792
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 109 bits (272), Expect = 6e-24
Identities = 77/210 (36%), Positives = 105/210 (50%), Gaps = 10/210 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGAD-PDASPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
+PL +AA H CV+HLL A D + ALH A GH +LLL RA+P+
Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PLH+ + + L+++GAS+Q + +G TP+HVAA G L L
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL-TPIHVAAFMGHLNIVLLLLQ 452
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
GA D N RGETAL A A + + + LLR GA DAR +E++PLH A
Sbjct: 453 NGASPDVTNIRGETALHMAARAGQ--------VEVVRCLLRNGALVDARAREEQTPLHIA 504
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
+ +LLL+H A A G +PL
Sbjct: 505 SRLGKTEIVQLLLQHMAHPDAATTNGYTPL 534
Score = 93.6 bits (231), Expect = 3e-19
Identities = 75/210 (35%), Positives = 98/210 (46%), Gaps = 10/210 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
T L +AA G VR LL GA DA + + LH A G T V+LLLQH A PD
Sbjct: 466 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 525
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PLH+ + A LLE GA+ G TPLHVAA+ G + A+L L
Sbjct: 526 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG-FTPLHVAAKYGSLDVAKLLLQ 584
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
R A D+ G T L A H ++ LLL +GA A ++ +PLH A
Sbjct: 585 RRAAADSAGKNGLTPLHVAA--------HYDNQKVALLLLEKGASPHATAKNGYTPLHIA 636
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
+A LL +GA+ + G +PL
Sbjct: 637 AKKNQMQIASTLLNYGAETNIVTKQGVTPL 666
Score = 89.0 bits (219), Expect = 8e-18
Identities = 76/237 (32%), Positives = 108/237 (45%), Gaps = 17/237 (7%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +A+ G+T V+ LL RG DA G LH A GH V LLL+ A
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ GL+PLH+ + C + LL+H A V V T LHVAA G +L L
Sbjct: 328 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDV-TLDYLTALHVAAHCGHYRVTKLLLD 386
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
+ A+ +AR G T L AC R +++ LL++ GA A E +P+H A
Sbjct: 387 KRANPNARALNGFTPLHIACKKNR--------IKVMELLVKYGASIQAITESGLTPIHVA 438
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGS 357
++ LLL++GA + G + L A +A V+ LL +G+
Sbjct: 439 AFMGHLNIVLLLLQNGASPDVTNIRGETAL-------HMAARAGQVEVVRCLLRNGA 488
Score = 88.2 bits (217), Expect = 1e-17
Identities = 70/237 (29%), Positives = 103/237 (43%), Gaps = 17/237 (7%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPD-ASPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA +G + LL R A D A G LH A + LLL+ A P
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PLH+ + A LL +GA V G TPLH+A+Q G + L L
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTLLLD 683
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
+GA++ G T+L A + + + +L + GA+ DA + +PL A
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDK--------VNVADILTKHGADQDAHTKLGYTPLIVA 735
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGS 357
C + + + LL+ GA+ A G +PL + A Q + LL HG+
Sbjct: 736 CHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQ-------AAQQGHTHIINVLLQHGA 785
Score = 84.0 bits (206), Expect = 3e-16
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 52/272 (19%)
Query: 124 LCIAAAHGHTACVRHLLGRGADPD-ASPGGRGALHEACLGGHTACVRLLLQHRADPDLLS 182
L +AA GH V+ LLGRG+ D A+ G ALH A L G V++L++ A+ + S
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 183 AEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRG 242
G PL++ + + LLE+GA+ Q TPL VA Q+G ++ + L
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGAN-QSTATEDGFTPLAVALQQGHNQAVAILL--- 183
Query: 243 AHVDARNGRGETALSAACGAARRPDEHGRCLRL--------------------------- 275
+ +G+ L A AAR+ D L L
Sbjct: 184 ----ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239
Query: 276 ---------CALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGG 326
LLL RGA D + +PLH A + ++ +LLL G A G
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 327 ASPLGRVLQTASCALQASPQRTVQALLNHGSP 358
+PL CA ++ + V+ LL G+P
Sbjct: 300 LTPL-------HCAARSGHDQVVELLLERGAP 324
Score = 83.6 bits (205), Expect = 4e-16
Identities = 62/210 (29%), Positives = 96/210 (45%), Gaps = 10/210 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA + + LL +GA P A+ G LH A LL + A+ ++
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
++ +G+ PLHL LL+ GA++ +G T LH+AAQ A +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL-TSLHLAAQEDKVNVADILTK 716
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
GA DA G T L AC H +++ LL++GA +A+ ++ +PLH+A
Sbjct: 717 HGADQDAHTKLGYTPLIVAC--------HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
+ +LL+HGA A G + L
Sbjct: 769 AQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Score = 81.6 bits (200), Expect = 1e-15
Identities = 81/245 (33%), Positives = 103/245 (42%), Gaps = 27/245 (11%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPD-ASPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA H V++LL GA+ A+ G L A GH V +LL++ D
Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN----DT 187
Query: 181 LSAEGLAPLHLCRTAASLGCAQALL--EHGASVQRVGGTGRD-----TPLHVAAQRGLDE 233
L LH+ A LL +H A VQ R TPLH+AA G
Sbjct: 188 KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVN 247
Query: 234 HARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDE 293
A L L RGA VD G T L A++R + + + LLL RG + DA+ D
Sbjct: 248 VATLLLNRGAAVDFTARNGITPLHV---ASKRGNTN-----MVKLLLDRGGQIDAKTRDG 299
Query: 294 RSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALL 353
+PLH A + LLL GA A G SPL A Q V+ LL
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL-------HMAAQGDHVECVKHLL 352
Query: 354 NHGSP 358
H +P
Sbjct: 353 QHKAP 357
Score = 79.3 bits (194), Expect = 7e-15
Identities = 74/241 (30%), Positives = 100/241 (41%), Gaps = 17/241 (7%)
Query: 118 RELTTPLCIAAAHGHTACVRHLLGRGADPD-ASPGGRGALHEACLGGHTACVRLLLQHRA 176
RE TPL IA+ G T V+ LL A PD A+ G LH + G +LL+ A
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554
Query: 177 DPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHAR 236
L + +G PLH+ SL A+ LL+ A+ G G TPLHVAA + A
Sbjct: 555 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-TPLHVAAHYDNQKVAL 613
Query: 237 LYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSP 296
L L +GA A G T L A + +++ + LL GAE + + +P
Sbjct: 614 LLLEKGASPHATAKNGYTPLHIAAKKNQ--------MQIASTLLNYGAETNIVTKQGVTP 665
Query: 297 LHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHG 356
LH A + LLL GA+ G L + A Q L HG
Sbjct: 666 LHLASQEGHTDMVTLLLDKGANIHMSTKSG-------LTSLHLAAQEDKVNVADILTKHG 718
Query: 357 S 357
+
Sbjct: 719 A 719
Score = 62.0 bits (149), Expect = 1e-09
Identities = 48/139 (34%), Positives = 65/139 (46%), Gaps = 2/139 (1%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +A+ GHT V LL +GA+ S G +LH A +L +H AD D
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PL + ++ LL+ GA+V G TPLH AAQ+G + L
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQAAQQGHTHIINVLLQ 782
Query: 241 RGAHVDARNGRGETALSAA 259
GA +A G TAL+ A
Sbjct: 783 HGAKPNATTANGNTALAIA 801
Score = 49.3 bits (116), Expect = 7e-06
Identities = 28/84 (33%), Positives = 43/84 (51%), Gaps = 1/84 (1%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +A +G+ V LL +GA+ +A + G LH+A GHT + +LLQH A P+
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 181 LSAEGLAPLHLCRTAASLGCAQAL 204
+A G L + + + L
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTL 813
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 109 bits (272), Expect = 6e-24
Identities = 77/210 (36%), Positives = 105/210 (50%), Gaps = 10/210 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGAD-PDASPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
+PL +AA H CV+HLL A D + ALH A GH +LLL RA+P+
Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PLH+ + + L+++GAS+Q + +G TP+HVAA G L L
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL-TPIHVAAFMGHLNIVLLLLQ 452
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
GA D N RGETAL A A + + + LLR GA DAR +E++PLH A
Sbjct: 453 NGASPDVTNIRGETALHMAARAGQ--------VEVVRCLLRNGALVDARAREEQTPLHIA 504
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
+ +LLL+H A A G +PL
Sbjct: 505 SRLGKTEIVQLLLQHMAHPDAATTNGYTPL 534
Score = 93.6 bits (231), Expect = 3e-19
Identities = 75/210 (35%), Positives = 98/210 (46%), Gaps = 10/210 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
T L +AA G VR LL GA DA + + LH A G T V+LLLQH A PD
Sbjct: 466 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 525
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PLH+ + A LLE GA+ G TPLHVAA+ G + A+L L
Sbjct: 526 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG-FTPLHVAAKYGSLDVAKLLLQ 584
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
R A D+ G T L A H ++ LLL +GA A ++ +PLH A
Sbjct: 585 RRAAADSAGKNGLTPLHVAA--------HYDNQKVALLLLEKGASPHATAKNGYTPLHIA 636
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
+A LL +GA+ + G +PL
Sbjct: 637 AKKNQMQIASTLLNYGAETNIVTKQGVTPL 666
Score = 89.0 bits (219), Expect = 8e-18
Identities = 76/237 (32%), Positives = 108/237 (45%), Gaps = 17/237 (7%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +A+ G+T V+ LL RG DA G LH A GH V LLL+ A
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ GL+PLH+ + C + LL+H A V V T LHVAA G +L L
Sbjct: 328 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDV-TLDYLTALHVAAHCGHYRVTKLLLD 386
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
+ A+ +AR G T L AC R +++ LL++ GA A E +P+H A
Sbjct: 387 KRANPNARALNGFTPLHIACKKNR--------IKVMELLVKYGASIQAITESGLTPIHVA 438
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGS 357
++ LLL++GA + G + L A +A V+ LL +G+
Sbjct: 439 AFMGHLNIVLLLLQNGASPDVTNIRGETAL-------HMAARAGQVEVVRCLLRNGA 488
Score = 88.2 bits (217), Expect = 1e-17
Identities = 70/237 (29%), Positives = 103/237 (43%), Gaps = 17/237 (7%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPD-ASPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA +G + LL R A D A G LH A + LLL+ A P
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PLH+ + A LL +GA V G TPLH+A+Q G + L L
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTLLLD 683
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
+GA++ G T+L A + + + +L + GA+ DA + +PL A
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDK--------VNVADILTKHGADQDAHTKLGYTPLIVA 735
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGS 357
C + + + LL+ GA+ A G +PL + A Q + LL HG+
Sbjct: 736 CHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQ-------AAQQGHTHIINVLLQHGA 785
Score = 84.0 bits (206), Expect = 3e-16
Identities = 76/272 (27%), Positives = 112/272 (41%), Gaps = 52/272 (19%)
Query: 124 LCIAAAHGHTACVRHLLGRGADPD-ASPGGRGALHEACLGGHTACVRLLLQHRADPDLLS 182
L +AA GH V+ LLGRG+ D A+ G ALH A L G V++L++ A+ + S
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 183 AEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRG 242
G PL++ + + LLE+GA+ Q TPL VA Q+G ++ + L
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGAN-QSTATEDGFTPLAVALQQGHNQAVAILL--- 183
Query: 243 AHVDARNGRGETALSAACGAARRPDEHGRCLRL--------------------------- 275
+ +G+ L A AAR+ D L L
Sbjct: 184 ----ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239
Query: 276 ---------CALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGG 326
LLL RGA D + +PLH A + ++ +LLL G A G
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 327 ASPLGRVLQTASCALQASPQRTVQALLNHGSP 358
+PL CA ++ + V+ LL G+P
Sbjct: 300 LTPL-------HCAARSGHDQVVELLLERGAP 324
Score = 83.6 bits (205), Expect = 4e-16
Identities = 62/210 (29%), Positives = 96/210 (45%), Gaps = 10/210 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA + + LL +GA P A+ G LH A LL + A+ ++
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
++ +G+ PLHL LL+ GA++ +G T LH+AAQ A +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL-TSLHLAAQEDKVNVADILTK 716
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
GA DA G T L AC H +++ LL++GA +A+ ++ +PLH+A
Sbjct: 717 HGADQDAHTKLGYTPLIVAC--------HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
+ +LL+HGA A G + L
Sbjct: 769 AQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Score = 81.6 bits (200), Expect = 1e-15
Identities = 81/245 (33%), Positives = 103/245 (42%), Gaps = 27/245 (11%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPD-ASPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA H V++LL GA+ A+ G L A GH V +LL++ D
Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN----DT 187
Query: 181 LSAEGLAPLHLCRTAASLGCAQALL--EHGASVQRVGGTGRD-----TPLHVAAQRGLDE 233
L LH+ A LL +H A VQ R TPLH+AA G
Sbjct: 188 KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVN 247
Query: 234 HARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDE 293
A L L RGA VD G T L A++R + + + LLL RG + DA+ D
Sbjct: 248 VATLLLNRGAAVDFTARNGITPLHV---ASKRGNTN-----MVKLLLDRGGQIDAKTRDG 299
Query: 294 RSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALL 353
+PLH A + LLL GA A G SPL A Q V+ LL
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL-------HMAAQGDHVECVKHLL 352
Query: 354 NHGSP 358
H +P
Sbjct: 353 QHKAP 357
Score = 79.3 bits (194), Expect = 7e-15
Identities = 74/241 (30%), Positives = 100/241 (41%), Gaps = 17/241 (7%)
Query: 118 RELTTPLCIAAAHGHTACVRHLLGRGADPD-ASPGGRGALHEACLGGHTACVRLLLQHRA 176
RE TPL IA+ G T V+ LL A PD A+ G LH + G +LL+ A
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554
Query: 177 DPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHAR 236
L + +G PLH+ SL A+ LL+ A+ G G TPLHVAA + A
Sbjct: 555 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-TPLHVAAHYDNQKVAL 613
Query: 237 LYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSP 296
L L +GA A G T L A + +++ + LL GAE + + +P
Sbjct: 614 LLLEKGASPHATAKNGYTPLHIAAKKNQ--------MQIASTLLNYGAETNIVTKQGVTP 665
Query: 297 LHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHG 356
LH A + LLL GA+ G L + A Q L HG
Sbjct: 666 LHLASQEGHTDMVTLLLDKGANIHMSTKSG-------LTSLHLAAQEDKVNVADILTKHG 718
Query: 357 S 357
+
Sbjct: 719 A 719
Score = 62.0 bits (149), Expect = 1e-09
Identities = 48/139 (34%), Positives = 65/139 (46%), Gaps = 2/139 (1%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +A+ GHT V LL +GA+ S G +LH A +L +H AD D
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PL + ++ LL+ GA+V G TPLH AAQ+G + L
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQAAQQGHTHIINVLLQ 782
Query: 241 RGAHVDARNGRGETALSAA 259
GA +A G TAL+ A
Sbjct: 783 HGAKPNATTANGNTALAIA 801
Score = 49.3 bits (116), Expect = 7e-06
Identities = 28/84 (33%), Positives = 43/84 (51%), Gaps = 1/84 (1%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +A +G+ V LL +GA+ +A + G LH+A GHT + +LLQH A P+
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 181 LSAEGLAPLHLCRTAASLGCAQAL 204
+A G L + + + L
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTL 813
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 106 bits (264), Expect = 5e-23
Identities = 90/260 (34%), Positives = 104/260 (40%), Gaps = 43/260 (16%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +A GH VR LL RGA A GR ALHEA GH+ LLLQ A
Sbjct: 76 TPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAA 135
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLE--------------------HGAS---------V 211
S GL PLH A LLE H A+ +
Sbjct: 136 RSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLEL 195
Query: 212 QRVGGTGRDTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGR 271
GG G D L VAA G R L RGA VDAR+G G TAL A R D
Sbjct: 196 LAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQD---- 251
Query: 272 CLRLCALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLG 331
+LL GA+ RD RS LH+A +LL+ GA+ A D G +PL
Sbjct: 252 ----IEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLH 307
Query: 332 RV-----LQTASCALQASPQ 346
++ A C L Q
Sbjct: 308 HASREGHVEVAGCLLDRGAQ 327
Score = 80.1 bits (196), Expect = 4e-15
Identities = 55/135 (40%), Positives = 65/135 (48%), Gaps = 2/135 (1%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQHRADPDL 180
T L +AAA G + + LLG GADP GR ALH A GH V+LL+ A+ D
Sbjct: 238 TALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDA 297
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
GL PLH + A LL+ GA V G R TPLH+AA+RG L L
Sbjct: 298 RDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWL-RKTPLHLAAERGHGPTVGLLLS 356
Query: 241 RGAHVDARNGRGETA 255
RGA R E A
Sbjct: 357 RGASPTLRTQWAEVA 371
Score = 72.8 bits (177), Expect = 6e-13
Identities = 82/232 (35%), Positives = 91/232 (39%), Gaps = 30/232 (12%)
Query: 127 AAAHGHTACVRHLLGRGAD-PDASPGGRGALHEACLGGHTACVRLLLQHRADPDLLSAEG 185
A G V LL +GA + GR LH A L GH VRLLLQ A + G
Sbjct: 48 AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107
Query: 186 LAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLD-EHARLYLGRG-- 242
LH A+ LL+ GAS GTG TPLH AA G ARL G
Sbjct: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGL-TPLHWAAALGHTLLAARLLEAPGPG 166
Query: 243 -AHVDARNGRGETA--------------LSAACGA-------ARRPDEHGRCLRLCALLL 280
A +A + RG TA L AA GA G LR LL
Sbjct: 167 PAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALR---FLL 223
Query: 281 RRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGR 332
RGA DARD + L A +LL HGAD G D G S L R
Sbjct: 224 ARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHR 275
>gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2
[Homo sapiens]
Length = 262
Score = 102 bits (255), Expect = 6e-22
Identities = 72/210 (34%), Positives = 107/210 (50%), Gaps = 12/210 (5%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPGGR-GALHEACLGGHTACVRLLLQHRADPDL 180
+P+ AA HGH +R+L+ +G + LHEACLGGH +CV++LL+H A +
Sbjct: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
++A+ PL + S C LL+HGASVQ +P+H AA+RG E +
Sbjct: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA--SPIHEAARRGHVECVNSLIA 155
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
G ++D + T L AC +R C++ LL GA+ + + + + SPLH
Sbjct: 156 YGGNIDHKISHLGTPLYLACENQQR-----ACVK---KLLESGADVN-QGKGQDSPLHAV 206
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
AS LA LL+ GAD A + G P+
Sbjct: 207 ARTASEELACLLMDFGADTQAKNAEGKRPV 236
Score = 47.8 bits (112), Expect = 2e-05
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 2/108 (1%)
Query: 113 TLEYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGA-LHEACLGGHTACVRLL 171
+++ + +L +P+ AA GH CV L+ G + D G L+ AC ACV+ L
Sbjct: 127 SVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKL 186
Query: 172 LQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGR 219
L+ AD + + +PLH AS A L++ GA Q G+
Sbjct: 187 LESGADVNQGKGQD-SPLHAVARTASEELACLLMDFGADTQAKNAEGK 233
Score = 43.5 bits (101), Expect = 4e-04
Identities = 33/95 (34%), Positives = 43/95 (45%), Gaps = 3/95 (3%)
Query: 120 LTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPD 179
L TPL +A + ACV+ LL GAD + G LH LL+ AD
Sbjct: 167 LGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQ 226
Query: 180 LLSAEGLAPLHLCRTAASLGCAQALLE-HGASVQR 213
+AEG P+ L + L AQ LE GAS+ +
Sbjct: 227 AKNAEGKRPVELVPPESPL--AQLFLEREGASLPK 259
>gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1
[Homo sapiens]
Length = 294
Score = 102 bits (255), Expect = 6e-22
Identities = 72/210 (34%), Positives = 107/210 (50%), Gaps = 12/210 (5%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPGGR-GALHEACLGGHTACVRLLLQHRADPDL 180
+P+ AA HGH +R+L+ +G + LHEACLGGH +CV++LL+H A +
Sbjct: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
++A+ PL + S C LL+HGASVQ +P+H AA+RG E +
Sbjct: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLA--SPIHEAARRGHVECVNSLIA 155
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
G ++D + T L AC +R C++ LL GA+ + + + + SPLH
Sbjct: 156 YGGNIDHKISHLGTPLYLACENQQR-----ACVK---KLLESGADVN-QGKGQDSPLHAV 206
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
AS LA LL+ GAD A + G P+
Sbjct: 207 ARTASEELACLLMDFGADTQAKNAEGKRPV 236
Score = 47.8 bits (112), Expect = 2e-05
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 2/108 (1%)
Query: 113 TLEYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGA-LHEACLGGHTACVRLL 171
+++ + +L +P+ AA GH CV L+ G + D G L+ AC ACV+ L
Sbjct: 127 SVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKL 186
Query: 172 LQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGR 219
L+ AD + + +PLH AS A L++ GA Q G+
Sbjct: 187 LESGADVNQGKGQD-SPLHAVARTASEELACLLMDFGADTQAKNAEGK 233
Score = 42.0 bits (97), Expect = 0.001
Identities = 30/87 (34%), Positives = 38/87 (43%), Gaps = 2/87 (2%)
Query: 120 LTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPD 179
L TPL +A + ACV+ LL GAD + G LH LL+ AD
Sbjct: 167 LGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQ 226
Query: 180 LLSAEGLAPLHLCRTAASLGCAQALLE 206
+AEG P+ L + L AQ LE
Sbjct: 227 AKNAEGKRPVELVPPESPL--AQLFLE 251
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 97.4 bits (241), Expect = 2e-20
Identities = 66/190 (34%), Positives = 90/190 (47%), Gaps = 9/190 (4%)
Query: 152 GRGALHEACLGGHTACVRLLLQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASV 211
G+ H A G T C+ +LL + AD + + +G LHL + C + LL+HGA+
Sbjct: 54 GQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANE 113
Query: 212 QRVGGTGRDTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGR 271
V R +PLH AA G L A +D + G T L A G
Sbjct: 114 DAVDAENR-SPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIA--------SLGG 164
Query: 272 CLRLCALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLG 331
+C+ LL+RGA + D++++S L AC S +A LLL HGADAGA+D G L
Sbjct: 165 HAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALH 224
Query: 332 RVLQTASCAL 341
L T AL
Sbjct: 225 YALHTQDKAL 234
Score = 92.0 bits (227), Expect = 1e-18
Identities = 80/228 (35%), Positives = 112/228 (49%), Gaps = 23/228 (10%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
+P +AA+ G T C+ LL GAD ++ + G ALH A + CV++LLQH A+ D
Sbjct: 56 SPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDA 115
Query: 181 LSAEGLAPLHLCRTAASLGCAQALL---EHGASVQRVGGTGRDTPLHVAAQRGLDEHARL 237
+ AE +PLH AAS GCA ++L +H A + + GR TPL +A+ G
Sbjct: 116 VDAENRSPLH---WAASSGCASSVLLLCDHEAFLDVLDNDGR-TPLMIASLGGHAAICSQ 171
Query: 238 YLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPL 297
L RGA V+ + ++AL AC E G + LLL GA+A A D L
Sbjct: 172 LLQRGARVNVTDKNDKSALILAC-------EKGSA-EVAELLLSHGADAGAVDSTGHDAL 223
Query: 298 HKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASP 345
H +A H+ + L RH A + G R++Q A QASP
Sbjct: 224 H----YALHTQDKALWRHLQQALSRRRRGGQ---RLVQHPDLASQASP 264
Score = 57.4 bits (137), Expect = 3e-08
Identities = 46/140 (32%), Positives = 60/140 (42%), Gaps = 2/140 (1%)
Query: 121 TTPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRADPD 179
+T L +A CV+ LL GA+ DA R LH A G + V LL H A D
Sbjct: 88 STALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLD 147
Query: 180 LLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYL 239
+L +G PL + LL+ GA V V + L +A ++G E A L L
Sbjct: 148 VLDNDGRTPLMIASLGGHAAICSQLLQRGARV-NVTDKNDKSALILACEKGSAEVAELLL 206
Query: 240 GRGAHVDARNGRGETALSAA 259
GA A + G AL A
Sbjct: 207 SHGADAGAVDSTGHDALHYA 226
Score = 38.1 bits (87), Expect = 0.017
Identities = 27/84 (32%), Positives = 39/84 (46%), Gaps = 7/84 (8%)
Query: 274 RLCALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRV 333
R+ AL R+ A D + +SP H A +LL +GAD + + G++ L
Sbjct: 35 RVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALH-- 92
Query: 334 LQTASCALQASPQRTVQALLNHGS 357
L T SC Q V+ LL HG+
Sbjct: 93 LATISCQPQC-----VKVLLQHGA 111
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 97.1 bits (240), Expect = 3e-20
Identities = 78/226 (34%), Positives = 106/226 (46%), Gaps = 10/226 (4%)
Query: 119 ELTTPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRAD 177
++ TPL +AA GHT ++LL A +A + + LH A GHT V+LLL++ A+
Sbjct: 469 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 528
Query: 178 PDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARL 237
P+L + G PLH+ + ALLE AS + G TPLHVAA+ G A L
Sbjct: 529 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG-FTPLHVAAKYGKVRVAEL 587
Query: 238 YLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPL 297
L R AH +A G T L A H L + LLL RG + + +PL
Sbjct: 588 LLERDAHPNAAGKNGLTPLHVAV--------HHNNLDIVKLLLPRGGSPHSPAWNGYTPL 639
Query: 298 HKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQA 343
H A +AR LL++G A A G +PL Q + A
Sbjct: 640 HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 685
Score = 94.7 bits (234), Expect = 2e-19
Identities = 74/236 (31%), Positives = 103/236 (43%), Gaps = 19/236 (8%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDLL 181
TPL +A GH V HL+ G ALH A T +LLQ+ +PD+L
Sbjct: 179 TPLAVALQQGHENVVAHLINYGTKGKVR---LPALHIAARNDDTRTAAVLLQNDPNPDVL 235
Query: 182 SAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGR 241
S G PLH+ +L AQ LL GASV G TPLH+A++RG RL L R
Sbjct: 236 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG-ITPLHIASRRGNVIMVRLLLDR 294
Query: 242 GAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKAC 301
GA ++ + T L A +R+ +LL GA A+ ++ SP+H A
Sbjct: 295 GAQIETKTKDELTPLHCAARNGH--------VRISEILLDHGAPIQAKTKNGLSPIHMAA 346
Query: 302 GHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGS 357
RLLL++ A+ + +PL A R + LL+ G+
Sbjct: 347 QGDHLDCVRLLLQYDAEIDDITLDHLTPL-------HVAAHCGHHRVAKVLLDKGA 395
Score = 86.3 bits (212), Expect = 5e-17
Identities = 85/289 (29%), Positives = 120/289 (41%), Gaps = 23/289 (7%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDAS-PGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA +G LL R A P+A+ G LH A + V+LLL P
Sbjct: 571 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 630
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PLH+ + A++LL++G S G TPLH+AAQ G E L L
Sbjct: 631 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 689
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
+ A+ + N G T L P + +L++ G DA +PLH A
Sbjct: 690 KQANGNLGNKSGLTPLHLVAQEGHVP--------VADVLIKHGVMVDATTRMGYTPLHVA 741
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGSPT- 359
+ + L + LL+H AD A G SPL + Q Q L N SP
Sbjct: 742 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ------QGHTDIVTLLLKNGASPNE 795
Query: 360 -----VWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEV 403
P A K L SV V++V+ + + +S+ + PE V
Sbjct: 796 VSSDGTTPLAIAKRL-GYISVTDVLKVVTDETSFVLVSDKHRMSFPETV 843
Score = 81.3 bits (199), Expect = 2e-15
Identities = 69/212 (32%), Positives = 93/212 (43%), Gaps = 14/212 (6%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA GH + LL +GA P++ G LH AC H + LLL+ A D
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
++ GL PLH+ L + LL+ GAS V +TPLH+AA+ G E A+ L
Sbjct: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGAS-PNVSNVKVETPLHMAARAGHTEVAKYLLQ 491
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
A V+A+ +T L A + LLL A + +PLH A
Sbjct: 492 NKAKVNAKAKDDQTPLHCAARIGH--------TNMVKLLLENNANPNLATTAGHTPLHIA 543
Query: 301 C--GHASHSLARLLLRHGADAGALDYGGASPL 330
GH LA LL A + G +PL
Sbjct: 544 AREGHVETVLA--LLEKEASQACMTKKGFTPL 573
Score = 73.9 bits (180), Expect = 3e-13
Identities = 74/262 (28%), Positives = 111/262 (42%), Gaps = 40/262 (15%)
Query: 124 LCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQHRADPDLLS 182
L +A+ GH V LL + + + G ALH A L G VR L+ + A+ + S
Sbjct: 82 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 141
Query: 183 AEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRG 242
+G PL++ L + LLE+GA+ Q V TPL VA Q+G +
Sbjct: 142 QKGFTPLYMAAQENHLEVVKFLLENGAN-QNVATEDGFTPLAVALQQGHENVV------- 193
Query: 243 AHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKACG 302
AH+ +G+ L A AAR D R A+LL+ D + +PLH A
Sbjct: 194 AHLINYGTKGKVRLPALHIAARNDD-----TRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 248
Query: 303 HASHSLARLLLRHGADAGALDYGGASPL------------------GRVLQTAS------ 338
+ + ++A+LLL GA G +PL G ++T +
Sbjct: 249 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 308
Query: 339 --CALQASPQRTVQALLNHGSP 358
CA + R + LL+HG+P
Sbjct: 309 LHCAARNGHVRISEILLDHGAP 330
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 97.1 bits (240), Expect = 3e-20
Identities = 78/226 (34%), Positives = 106/226 (46%), Gaps = 10/226 (4%)
Query: 119 ELTTPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRAD 177
++ TPL +AA GHT ++LL A +A + + LH A GHT V+LLL++ A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Query: 178 PDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARL 237
P+L + G PLH+ + ALLE AS + G TPLHVAA+ G A L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG-FTPLHVAAKYGKVRVAEL 554
Query: 238 YLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPL 297
L R AH +A G T L A H L + LLL RG + + +PL
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAV--------HHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606
Query: 298 HKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQA 343
H A +AR LL++G A A G +PL Q + A
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Score = 94.7 bits (234), Expect = 2e-19
Identities = 74/236 (31%), Positives = 103/236 (43%), Gaps = 19/236 (8%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDLL 181
TPL +A GH V HL+ G ALH A T +LLQ+ +PD+L
Sbjct: 146 TPLAVALQQGHENVVAHLINYGTKGKVR---LPALHIAARNDDTRTAAVLLQNDPNPDVL 202
Query: 182 SAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGR 241
S G PLH+ +L AQ LL GASV G TPLH+A++RG RL L R
Sbjct: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG-ITPLHIASRRGNVIMVRLLLDR 261
Query: 242 GAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKAC 301
GA ++ + T L A +R+ +LL GA A+ ++ SP+H A
Sbjct: 262 GAQIETKTKDELTPLHCAARNGH--------VRISEILLDHGAPIQAKTKNGLSPIHMAA 313
Query: 302 GHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGS 357
RLLL++ A+ + +PL A R + LL+ G+
Sbjct: 314 QGDHLDCVRLLLQYDAEIDDITLDHLTPL-------HVAAHCGHHRVAKVLLDKGA 362
Score = 86.3 bits (212), Expect = 5e-17
Identities = 85/289 (29%), Positives = 120/289 (41%), Gaps = 23/289 (7%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDAS-PGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA +G LL R A P+A+ G LH A + V+LLL P
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PLH+ + A++LL++G S G TPLH+AAQ G E L L
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
+ A+ + N G T L P + +L++ G DA +PLH A
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVP--------VADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGSPT- 359
+ + L + LL+H AD A G SPL + Q Q L N SP
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ------QGHTDIVTLLLKNGASPNE 762
Query: 360 -----VWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEV 403
P A K L SV V++V+ + + +S+ + PE V
Sbjct: 763 VSSDGTTPLAIAKRL-GYISVTDVLKVVTDETSFVLVSDKHRMSFPETV 810
Score = 81.3 bits (199), Expect = 2e-15
Identities = 69/212 (32%), Positives = 93/212 (43%), Gaps = 14/212 (6%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA GH + LL +GA P++ G LH AC H + LLL+ A D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
++ GL PLH+ L + LL+ GAS V +TPLH+AA+ G E A+ L
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGAS-PNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
A V+A+ +T L A + LLL A + +PLH A
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGH--------TNMVKLLLENNANPNLATTAGHTPLHIA 510
Query: 301 C--GHASHSLARLLLRHGADAGALDYGGASPL 330
GH LA LL A + G +PL
Sbjct: 511 AREGHVETVLA--LLEKEASQACMTKKGFTPL 540
Score = 73.9 bits (180), Expect = 3e-13
Identities = 74/262 (28%), Positives = 111/262 (42%), Gaps = 40/262 (15%)
Query: 124 LCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQHRADPDLLS 182
L +A+ GH V LL + + + G ALH A L G VR L+ + A+ + S
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 183 AEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRG 242
+G PL++ L + LLE+GA+ Q V TPL VA Q+G +
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGAN-QNVATEDGFTPLAVALQQGHENVV------- 160
Query: 243 AHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKACG 302
AH+ +G+ L A AAR D R A+LL+ D + +PLH A
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDD-----TRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 215
Query: 303 HASHSLARLLLRHGADAGALDYGGASPL------------------GRVLQTAS------ 338
+ + ++A+LLL GA G +PL G ++T +
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 339 --CALQASPQRTVQALLNHGSP 358
CA + R + LL+HG+P
Sbjct: 276 LHCAARNGHVRISEILLDHGAP 297
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 97.1 bits (240), Expect = 3e-20
Identities = 78/226 (34%), Positives = 106/226 (46%), Gaps = 10/226 (4%)
Query: 119 ELTTPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRAD 177
++ TPL +AA GHT ++LL A +A + + LH A GHT V+LLL++ A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Query: 178 PDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARL 237
P+L + G PLH+ + ALLE AS + G TPLHVAA+ G A L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG-FTPLHVAAKYGKVRVAEL 554
Query: 238 YLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPL 297
L R AH +A G T L A H L + LLL RG + + +PL
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAV--------HHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606
Query: 298 HKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQA 343
H A +AR LL++G A A G +PL Q + A
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Score = 94.7 bits (234), Expect = 2e-19
Identities = 74/236 (31%), Positives = 103/236 (43%), Gaps = 19/236 (8%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDLL 181
TPL +A GH V HL+ G ALH A T +LLQ+ +PD+L
Sbjct: 146 TPLAVALQQGHENVVAHLINYGTKGKVR---LPALHIAARNDDTRTAAVLLQNDPNPDVL 202
Query: 182 SAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGR 241
S G PLH+ +L AQ LL GASV G TPLH+A++RG RL L R
Sbjct: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG-ITPLHIASRRGNVIMVRLLLDR 261
Query: 242 GAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKAC 301
GA ++ + T L A +R+ +LL GA A+ ++ SP+H A
Sbjct: 262 GAQIETKTKDELTPLHCAARNGH--------VRISEILLDHGAPIQAKTKNGLSPIHMAA 313
Query: 302 GHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGS 357
RLLL++ A+ + +PL A R + LL+ G+
Sbjct: 314 QGDHLDCVRLLLQYDAEIDDITLDHLTPL-------HVAAHCGHHRVAKVLLDKGA 362
Score = 86.3 bits (212), Expect = 5e-17
Identities = 85/289 (29%), Positives = 120/289 (41%), Gaps = 23/289 (7%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDAS-PGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA +G LL R A P+A+ G LH A + V+LLL P
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PLH+ + A++LL++G S G TPLH+AAQ G E L L
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
+ A+ + N G T L P + +L++ G DA +PLH A
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVP--------VADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGSPT- 359
+ + L + LL+H AD A G SPL + Q Q L N SP
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ------QGHTDIVTLLLKNGASPNE 762
Query: 360 -----VWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEV 403
P A K L SV V++V+ + + +S+ + PE V
Sbjct: 763 VSSDGTTPLAIAKRL-GYISVTDVLKVVTDETSFVLVSDKHRMSFPETV 810
Score = 81.3 bits (199), Expect = 2e-15
Identities = 69/212 (32%), Positives = 93/212 (43%), Gaps = 14/212 (6%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA GH + LL +GA P++ G LH AC H + LLL+ A D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
++ GL PLH+ L + LL+ GAS V +TPLH+AA+ G E A+ L
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGAS-PNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
A V+A+ +T L A + LLL A + +PLH A
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGH--------TNMVKLLLENNANPNLATTAGHTPLHIA 510
Query: 301 C--GHASHSLARLLLRHGADAGALDYGGASPL 330
GH LA LL A + G +PL
Sbjct: 511 AREGHVETVLA--LLEKEASQACMTKKGFTPL 540
Score = 73.9 bits (180), Expect = 3e-13
Identities = 74/262 (28%), Positives = 111/262 (42%), Gaps = 40/262 (15%)
Query: 124 LCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQHRADPDLLS 182
L +A+ GH V LL + + + G ALH A L G VR L+ + A+ + S
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 183 AEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRG 242
+G PL++ L + LLE+GA+ Q V TPL VA Q+G +
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGAN-QNVATEDGFTPLAVALQQGHENVV------- 160
Query: 243 AHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKACG 302
AH+ +G+ L A AAR D R A+LL+ D + +PLH A
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDD-----TRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 215
Query: 303 HASHSLARLLLRHGADAGALDYGGASPL------------------GRVLQTAS------ 338
+ + ++A+LLL GA G +PL G ++T +
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 339 --CALQASPQRTVQALLNHGSP 358
CA + R + LL+HG+P
Sbjct: 276 LHCAARNGHVRISEILLDHGAP 297
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 97.1 bits (240), Expect = 3e-20
Identities = 78/226 (34%), Positives = 106/226 (46%), Gaps = 10/226 (4%)
Query: 119 ELTTPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRAD 177
++ TPL +AA GHT ++LL A +A + + LH A GHT V+LLL++ A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Query: 178 PDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARL 237
P+L + G PLH+ + ALLE AS + G TPLHVAA+ G A L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG-FTPLHVAAKYGKVRVAEL 554
Query: 238 YLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPL 297
L R AH +A G T L A H L + LLL RG + + +PL
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAV--------HHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606
Query: 298 HKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQA 343
H A +AR LL++G A A G +PL Q + A
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Score = 94.7 bits (234), Expect = 2e-19
Identities = 74/236 (31%), Positives = 103/236 (43%), Gaps = 19/236 (8%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDLL 181
TPL +A GH V HL+ G ALH A T +LLQ+ +PD+L
Sbjct: 146 TPLAVALQQGHENVVAHLINYGTKGKVR---LPALHIAARNDDTRTAAVLLQNDPNPDVL 202
Query: 182 SAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGR 241
S G PLH+ +L AQ LL GASV G TPLH+A++RG RL L R
Sbjct: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG-ITPLHIASRRGNVIMVRLLLDR 261
Query: 242 GAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKAC 301
GA ++ + T L A +R+ +LL GA A+ ++ SP+H A
Sbjct: 262 GAQIETKTKDELTPLHCAARNGH--------VRISEILLDHGAPIQAKTKNGLSPIHMAA 313
Query: 302 GHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGS 357
RLLL++ A+ + +PL A R + LL+ G+
Sbjct: 314 QGDHLDCVRLLLQYDAEIDDITLDHLTPL-------HVAAHCGHHRVAKVLLDKGA 362
Score = 86.3 bits (212), Expect = 5e-17
Identities = 85/289 (29%), Positives = 120/289 (41%), Gaps = 23/289 (7%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDAS-PGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA +G LL R A P+A+ G LH A + V+LLL P
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PLH+ + A++LL++G S G TPLH+AAQ G E L L
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
+ A+ + N G T L P + +L++ G DA +PLH A
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVP--------VADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGSPT- 359
+ + L + LL+H AD A G SPL + Q Q L N SP
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ------QGHTDIVTLLLKNGASPNE 762
Query: 360 -----VWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEV 403
P A K L SV V++V+ + + +S+ + PE V
Sbjct: 763 VSSDGTTPLAIAKRL-GYISVTDVLKVVTDETSFVLVSDKHRMSFPETV 810
Score = 81.3 bits (199), Expect = 2e-15
Identities = 69/212 (32%), Positives = 93/212 (43%), Gaps = 14/212 (6%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA GH + LL +GA P++ G LH AC H + LLL+ A D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
++ GL PLH+ L + LL+ GAS V +TPLH+AA+ G E A+ L
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGAS-PNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
A V+A+ +T L A + LLL A + +PLH A
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGH--------TNMVKLLLENNANPNLATTAGHTPLHIA 510
Query: 301 C--GHASHSLARLLLRHGADAGALDYGGASPL 330
GH LA LL A + G +PL
Sbjct: 511 AREGHVETVLA--LLEKEASQACMTKKGFTPL 540
Score = 73.9 bits (180), Expect = 3e-13
Identities = 74/262 (28%), Positives = 111/262 (42%), Gaps = 40/262 (15%)
Query: 124 LCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQHRADPDLLS 182
L +A+ GH V LL + + + G ALH A L G VR L+ + A+ + S
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 183 AEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRG 242
+G PL++ L + LLE+GA+ Q V TPL VA Q+G +
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGAN-QNVATEDGFTPLAVALQQGHENVV------- 160
Query: 243 AHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKACG 302
AH+ +G+ L A AAR D R A+LL+ D + +PLH A
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDD-----TRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 215
Query: 303 HASHSLARLLLRHGADAGALDYGGASPL------------------GRVLQTAS------ 338
+ + ++A+LLL GA G +PL G ++T +
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 339 --CALQASPQRTVQALLNHGSP 358
CA + R + LL+HG+P
Sbjct: 276 LHCAARNGHVRISEILLDHGAP 297
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 97.1 bits (240), Expect = 3e-20
Identities = 78/226 (34%), Positives = 106/226 (46%), Gaps = 10/226 (4%)
Query: 119 ELTTPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRAD 177
++ TPL +AA GHT ++LL A +A + + LH A GHT V+LLL++ A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Query: 178 PDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARL 237
P+L + G PLH+ + ALLE AS + G TPLHVAA+ G A L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG-FTPLHVAAKYGKVRVAEL 554
Query: 238 YLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPL 297
L R AH +A G T L A H L + LLL RG + + +PL
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAV--------HHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606
Query: 298 HKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQA 343
H A +AR LL++G A A G +PL Q + A
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Score = 94.7 bits (234), Expect = 2e-19
Identities = 74/236 (31%), Positives = 103/236 (43%), Gaps = 19/236 (8%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDLL 181
TPL +A GH V HL+ G ALH A T +LLQ+ +PD+L
Sbjct: 146 TPLAVALQQGHENVVAHLINYGTKGKVR---LPALHIAARNDDTRTAAVLLQNDPNPDVL 202
Query: 182 SAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGR 241
S G PLH+ +L AQ LL GASV G TPLH+A++RG RL L R
Sbjct: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG-ITPLHIASRRGNVIMVRLLLDR 261
Query: 242 GAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKAC 301
GA ++ + T L A +R+ +LL GA A+ ++ SP+H A
Sbjct: 262 GAQIETKTKDELTPLHCAARNGH--------VRISEILLDHGAPIQAKTKNGLSPIHMAA 313
Query: 302 GHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGS 357
RLLL++ A+ + +PL A R + LL+ G+
Sbjct: 314 QGDHLDCVRLLLQYDAEIDDITLDHLTPL-------HVAAHCGHHRVAKVLLDKGA 362
Score = 86.3 bits (212), Expect = 5e-17
Identities = 85/289 (29%), Positives = 120/289 (41%), Gaps = 23/289 (7%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDAS-PGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA +G LL R A P+A+ G LH A + V+LLL P
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PLH+ + A++LL++G S G TPLH+AAQ G E L L
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
+ A+ + N G T L P + +L++ G DA +PLH A
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVP--------VADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGSPT- 359
+ + L + LL+H AD A G SPL + Q Q L N SP
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ------QGHTDIVTLLLKNGASPNE 762
Query: 360 -----VWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEV 403
P A K L SV V++V+ + + +S+ + PE V
Sbjct: 763 VSSDGTTPLAIAKRL-GYISVTDVLKVVTDETSFVLVSDKHRMSFPETV 810
Score = 81.3 bits (199), Expect = 2e-15
Identities = 69/212 (32%), Positives = 93/212 (43%), Gaps = 14/212 (6%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA GH + LL +GA P++ G LH AC H + LLL+ A D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
++ GL PLH+ L + LL+ GAS V +TPLH+AA+ G E A+ L
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGAS-PNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
A V+A+ +T L A + LLL A + +PLH A
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGH--------TNMVKLLLENNANPNLATTAGHTPLHIA 510
Query: 301 C--GHASHSLARLLLRHGADAGALDYGGASPL 330
GH LA LL A + G +PL
Sbjct: 511 AREGHVETVLA--LLEKEASQACMTKKGFTPL 540
Score = 73.9 bits (180), Expect = 3e-13
Identities = 74/262 (28%), Positives = 111/262 (42%), Gaps = 40/262 (15%)
Query: 124 LCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQHRADPDLLS 182
L +A+ GH V LL + + + G ALH A L G VR L+ + A+ + S
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 183 AEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRG 242
+G PL++ L + LLE+GA+ Q V TPL VA Q+G +
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGAN-QNVATEDGFTPLAVALQQGHENVV------- 160
Query: 243 AHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKACG 302
AH+ +G+ L A AAR D R A+LL+ D + +PLH A
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDD-----TRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 215
Query: 303 HASHSLARLLLRHGADAGALDYGGASPL------------------GRVLQTAS------ 338
+ + ++A+LLL GA G +PL G ++T +
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 339 --CALQASPQRTVQALLNHGSP 358
CA + R + LL+HG+P
Sbjct: 276 LHCAARNGHVRISEILLDHGAP 297
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 95.9 bits (237), Expect = 7e-20
Identities = 72/231 (31%), Positives = 102/231 (44%), Gaps = 29/231 (12%)
Query: 121 TTPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRADPD 179
+TPL AA G V +LL GA+ A GG LH AC GH V LLL+H ADP+
Sbjct: 59 STPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118
Query: 180 LLSAEGLAPLHLCRTAASLGCAQALLEHGA--SVQRVGG---------------TG---R 219
PLH + LL+HGA +++ G TG +
Sbjct: 119 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKK 178
Query: 220 DTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALL 279
D L A ++ L + A +GR T L A G R +++ LL
Sbjct: 179 DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNR--------VKIVQLL 230
Query: 280 LRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPL 330
L+ GA+ A+D+ + PLH AC + + + LL++HGA A+D +PL
Sbjct: 231 LQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPL 281
Score = 80.1 bits (196), Expect = 4e-15
Identities = 64/218 (29%), Positives = 99/218 (45%), Gaps = 18/218 (8%)
Query: 115 EYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQ 173
E +E TPL +A+ H V ++ A +A G+ +LH A GH RLLL
Sbjct: 395 EKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLS 454
Query: 174 HRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRG-LD 232
+ DP+++S +G L + Q LL+ G S+ G + D L AA+ G ++
Sbjct: 455 YGCDPNIISLQGFTALQMGNENV-----QQLLQEGISL---GNSEADRQLLEAAKAGDVE 506
Query: 233 EHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDED 292
+L + + GR T L A G R + + LL+ GA+ A+D+
Sbjct: 507 TVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNR--------VSVVEYLLQHGADVHAKDKG 558
Query: 293 ERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPL 330
PLH AC + + +A LL++HGA D +PL
Sbjct: 559 GLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPL 596
Score = 78.2 bits (191), Expect = 1e-14
Identities = 78/267 (29%), Positives = 106/267 (39%), Gaps = 47/267 (17%)
Query: 121 TTPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPD 179
+TPL AA + + V +LL GAD A GG LH AC GH LL++H A +
Sbjct: 527 STPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVN 586
Query: 180 LLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYL 239
+ PLH + LL+HGA + G +TPL + D L
Sbjct: 587 VADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG-NTPLDLVKDGDTDIQD-LLR 644
Query: 240 GRGAHVDARN----------------------GRGETALSAACGAARRPDEHGRCLRLCA 277
G A +DA GR T L A G L +
Sbjct: 645 GDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNN--------LEVAE 696
Query: 278 LLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQ-- 335
LL+ GA+ +A+D+ PLH A + +A LL+++ A A D +PL Q
Sbjct: 697 YLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKG 756
Query: 336 -TASCALQASPQRTVQALLNHGS-PTV 360
T CAL LL HG+ PT+
Sbjct: 757 RTQLCAL----------LLAHGADPTL 773
Score = 68.6 bits (166), Expect = 1e-11
Identities = 69/257 (26%), Positives = 106/257 (41%), Gaps = 33/257 (12%)
Query: 121 TTPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPD 179
+TPL +AA + V+ LL GAD A G LH AC GH LL++H A +
Sbjct: 212 STPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVN 271
Query: 180 LLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDE------ 233
+ PLH + + LL +GA + + + +A L E
Sbjct: 272 AMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSA-IDLAPTPQLKERLAYEF 330
Query: 234 --HARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCL------------RLCALL 279
H+ L R A V R + LS + P H L ++C LL
Sbjct: 331 KGHSLLQAAREADVT----RIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELL 386
Query: 280 LRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASC 339
LR+GA + + ++ +PLH A A + + ++++H A ALD G + L R
Sbjct: 387 LRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHR------- 439
Query: 340 ALQASPQRTVQALLNHG 356
A +T + LL++G
Sbjct: 440 AAYCGHLQTCRLLLSYG 456
Score = 53.9 bits (128), Expect = 3e-07
Identities = 39/123 (31%), Positives = 55/123 (44%), Gaps = 8/123 (6%)
Query: 219 RDTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCAL 278
+ TPLH AA G + L GA+V AR+ G L AC + L
Sbjct: 58 KSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHA--------EVVNL 109
Query: 279 LLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTAS 338
LLR GA+ +ARD +PLH+A + +LL+HGA+ + G + L +A
Sbjct: 110 LLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAK 169
Query: 339 CAL 341
L
Sbjct: 170 AVL 172
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 95.1 bits (235), Expect = 1e-19
Identities = 68/196 (34%), Positives = 98/196 (50%), Gaps = 11/196 (5%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDAS--PGGRGALHEACLGGHTACVRLLLQHRADPD 179
+PL +AA +GHTA V+ LL G+D +A AL AC G T V LLL +A+ +
Sbjct: 1220 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1279
Query: 180 LLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVG-GTGRDTPLHVAAQRGLDEHARLY 238
+ GL PL + + LL+ GA V + RDT L +AA +G + L
Sbjct: 1280 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1339
Query: 239 LGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLH 298
+GRGAH+D RN +G T L A +G L + LL++ GA+ DA D + +PL
Sbjct: 1340 IGRGAHIDVRNKKGNTPLWLAA--------NGGHLDVVQLLVQAGADVDAADNRKITPLM 1391
Query: 299 KACGHASHSLARLLLR 314
A + R L++
Sbjct: 1392 AAFRKGHVKVVRYLVK 1407
Score = 85.9 bits (211), Expect = 7e-17
Identities = 83/259 (32%), Positives = 114/259 (44%), Gaps = 34/259 (13%)
Query: 124 LCIAAAHGHTACVRHLLGRGADPDASPGG-RGALHEACLGGHTACVRLLLQHRADPDLLS 182
L +A GH VR LL GAD + AL EAC+ GH RLLL A ++ +
Sbjct: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 464
Query: 183 AEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRG 242
+PL L + A L+E GAS++ V G TPL AA+ G +E L LG+G
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGY-TPLMEAAREGHEEMVALLLGQG 523
Query: 243 AHVDARNGRG-ETALSAAC--------------GA---------ARRPDEHGRCLRLCAL 278
A+++A+ ETAL+ AC GA + G L L
Sbjct: 524 ANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGH-LELVKY 582
Query: 279 LLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTAS 338
LL GA A + L AC + +A +LL+ GAD GG +PL +
Sbjct: 583 LLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK------ 636
Query: 339 CALQASPQRTVQALLNHGS 357
A +A TVQ L++ G+
Sbjct: 637 -AARAGHVCTVQFLISKGA 654
Score = 82.0 bits (201), Expect = 1e-15
Identities = 68/210 (32%), Positives = 97/210 (46%), Gaps = 9/210 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL AA GH V+ LL AD +A S G AL AC GG+ V++LL+ A +
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PL +A + A+ LLE+GA + +++ L +A +G E R L
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
GA + + TAL AC D H + + LLL GA+ + + SPL A
Sbjct: 423 AGADQEHKTDEMHTALMEAC-----MDGH---VEVARLLLDSGAQVNMPADSFESPLTLA 474
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
LA LL+ GA ++ G +PL
Sbjct: 475 ACGGHVELAALLIERGASLEEVNDEGYTPL 504
Score = 80.5 bits (197), Expect = 3e-15
Identities = 57/169 (33%), Positives = 81/169 (47%), Gaps = 10/169 (5%)
Query: 155 ALHEACLGGHTACVRLLLQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRV 214
AL AC GGH V+ LL+ A + +G PL L TA +G + LL++GA ++
Sbjct: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 1145
Query: 215 GGTGRDTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLR 274
+DTPL +A G E L L RGA+ + RN T LS A G +
Sbjct: 1146 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS--------GGYVN 1197
Query: 275 LCALLLRRGAEADARDEDER--SPLHKACGHASHSLARLLLRHGADAGA 321
+ +LL GAE ++R + SPL A + + +LLL G+D A
Sbjct: 1198 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINA 1246
Score = 80.5 bits (197), Expect = 3e-15
Identities = 73/222 (32%), Positives = 105/222 (47%), Gaps = 29/222 (13%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPG---GRGALHEACLGGHTACVRLLLQHRADP 178
TPL +AA+ G+ ++ LL GA+ ++ G G L A + GHTA V+LLL +D
Sbjct: 1185 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDI 1244
Query: 179 DLLSAEGLAPLHLCR-TAASLGCAQA-------LLEHGASVQRVGGTGRDTPLHVAAQRG 230
+ A + R TA +L C Q LL+ A+V+ TG TPL AA G
Sbjct: 1245 N-------AQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGL-TPLMEAASGG 1296
Query: 231 LDEHARLYLGRGAHVDARN--GRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADA 288
E R+ L +GA V+A +TAL+ A + C LL+ RGA D
Sbjct: 1297 YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGH--------YKFCELLIGRGAHIDV 1348
Query: 289 RDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPL 330
R++ +PL A + +LL++ GAD A D +PL
Sbjct: 1349 RNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1390
Score = 74.7 bits (182), Expect = 2e-13
Identities = 64/204 (31%), Positives = 89/204 (43%), Gaps = 12/204 (5%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPGGR--GALHEACLGGHTACVRLLLQHRADPD 179
TPL +AA GH V LL GAD +A L AC GG V LLL A+ +
Sbjct: 1118 TPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKE 1177
Query: 180 LLSAEGLAPLHLCRTAASLGCAQALLEHGASV-QRVGGTGRDTPLHVAAQRGLDEHARLY 238
+ PL L + + + LL GA + R G +PL +AA G +L
Sbjct: 1178 HRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 1237
Query: 239 LGRGAHVDAR-NGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPL 297
L G+ ++A+ TAL+ AC R + +LLL R A + R + +PL
Sbjct: 1238 LDMGSDINAQIETNRNTALTLACFQGR--------TEVVSLLLDRKANVEHRAKTGLTPL 1289
Query: 298 HKACGHASHSLARLLLRHGADAGA 321
+A + R+LL GAD A
Sbjct: 1290 MEAASGGYAEVGRVLLDKGADVNA 1313
Score = 70.5 bits (171), Expect = 3e-12
Identities = 64/201 (31%), Positives = 89/201 (44%), Gaps = 18/201 (8%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGAD-PDASPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
+PL +AA GH L+ RGA + + G L EA GH V LLL A+ +
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGT---GRDTPLHVAAQRGLDEHARL 237
+ E TA +L C LE + + G G TPL AAQ G E +
Sbjct: 529 QTEETQ------ETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKY 582
Query: 238 YLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPL 297
L GA+V A G+TAL+ AC E+G + +LL+ GA+ + E R+PL
Sbjct: 583 LLAAGANVHATTATGDTALTYAC-------ENGH-TDVADVLLQAGADLEHESEGGRTPL 634
Query: 298 HKACGHASHSLARLLLRHGAD 318
KA + L+ GA+
Sbjct: 635 MKAARAGHVCTVQFLISKGAN 655
Score = 69.3 bits (168), Expect = 7e-12
Identities = 66/204 (32%), Positives = 94/204 (46%), Gaps = 12/204 (5%)
Query: 115 EYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQH 174
E R LT+ + A A R + + +A +L EAC G VR LL
Sbjct: 199 EVLRRLTSSVSCALDEAAAALTR--MRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIE 256
Query: 175 RADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEH 234
+ + EG + L L +A AQ LL A+V+ G G TPL AA G +
Sbjct: 257 GRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKI 316
Query: 235 ARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDER 294
+L L A V+A++ G TAL+ AC G + + +LL GA + +E+
Sbjct: 317 VKLLLAHKADVNAQSSTGNTALTYACA--------GGYVDVVKVLLESGASIEDHNENGH 368
Query: 295 SPLHKACGHASH-SLARLLLRHGA 317
+PL +A G A H +ARLLL +GA
Sbjct: 369 TPLMEA-GSAGHVEVARLLLENGA 391
Score = 62.0 bits (149), Expect = 1e-09
Identities = 64/209 (30%), Positives = 89/209 (42%), Gaps = 19/209 (9%)
Query: 115 EYKRELTTPLCIAAAHGHTACVRHLLGRGADPDA--SPGGRGALHEACLGGHTACVRLLL 172
E E TPL AA GH V LLG+GA+ +A AL AC GG L+
Sbjct: 495 EVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLI 554
Query: 173 QHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLD 232
+ AD +L + PL L + LL GA+V TG DT L A + G
Sbjct: 555 KAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG-DTALTYACENGHT 610
Query: 233 EHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCAL--LLRRGAEAD-AR 289
+ A + L GA ++ + G T L A A +C + L+ +GA +
Sbjct: 611 DVADVLLQAGADLEHESEGGRTPLMKAARAG----------HVCTVQFLISKGANVNRTT 660
Query: 290 DEDERSPLHKACGHASHSLARLLLRHGAD 318
++ + L AC ++ LLL HGAD
Sbjct: 661 ANNDHTVLSLACAGGHLAVVELLLAHGAD 689
Score = 62.0 bits (149), Expect = 1e-09
Identities = 50/140 (35%), Positives = 61/140 (43%), Gaps = 1/140 (0%)
Query: 121 TTPLCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQHRADPD 179
+TPL AA GH V++LL GA+ A+ G AL AC GHT +LLQ AD +
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Query: 180 LLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYL 239
S G PL A + Q L+ GA+V R T L +A G L L
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
Query: 240 GRGAHVDARNGRGETALSAA 259
GA R G T L A
Sbjct: 685 AHGADPTHRLKDGSTMLIEA 704
Score = 45.1 bits (105), Expect = 1e-04
Identities = 39/142 (27%), Positives = 62/142 (43%), Gaps = 16/142 (11%)
Query: 217 TGRDTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLC 276
+ DT L +A G +E + L RGA ++ R+ +G T L A A + +
Sbjct: 1081 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGH--------VGVV 1132
Query: 277 ALLLRRGAEADARDEDER-SPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQ 335
+LL GA+ +A+ E + +PL AC + LLL GA+ + +PL
Sbjct: 1133 EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL----- 1187
Query: 336 TASCALQASPQRTVQALLNHGS 357
S A ++ LLN G+
Sbjct: 1188 --SLAASGGYVNIIKILLNAGA 1207
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 95.1 bits (235), Expect = 1e-19
Identities = 68/196 (34%), Positives = 98/196 (50%), Gaps = 11/196 (5%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDAS--PGGRGALHEACLGGHTACVRLLLQHRADPD 179
+PL +AA +GHTA V+ LL G+D +A AL AC G T V LLL +A+ +
Sbjct: 969 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1028
Query: 180 LLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVG-GTGRDTPLHVAAQRGLDEHARLY 238
+ GL PL + + LL+ GA V + RDT L +AA +G + L
Sbjct: 1029 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1088
Query: 239 LGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLH 298
+GRGAH+D RN +G T L A +G L + LL++ GA+ DA D + +PL
Sbjct: 1089 IGRGAHIDVRNKKGNTPLWLAA--------NGGHLDVVQLLVQAGADVDAADNRKITPLM 1140
Query: 299 KACGHASHSLARLLLR 314
A + R L++
Sbjct: 1141 AAFRKGHVKVVRYLVK 1156
Score = 85.9 bits (211), Expect = 7e-17
Identities = 83/259 (32%), Positives = 114/259 (44%), Gaps = 34/259 (13%)
Query: 124 LCIAAAHGHTACVRHLLGRGADPDASPGG-RGALHEACLGGHTACVRLLLQHRADPDLLS 182
L +A GH VR LL GAD + AL EAC+ GH RLLL A ++ +
Sbjct: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 464
Query: 183 AEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRG 242
+PL L + A L+E GAS++ V G TPL AA+ G +E L LG+G
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGY-TPLMEAAREGHEEMVALLLGQG 523
Query: 243 AHVDARNGRG-ETALSAAC--------------GA---------ARRPDEHGRCLRLCAL 278
A+++A+ ETAL+ AC GA + G L L
Sbjct: 524 ANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGH-LELVKY 582
Query: 279 LLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTAS 338
LL GA A + L AC + +A +LL+ GAD GG +PL +
Sbjct: 583 LLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK------ 636
Query: 339 CALQASPQRTVQALLNHGS 357
A +A TVQ L++ G+
Sbjct: 637 -AARAGHVCTVQFLISKGA 654
Score = 82.0 bits (201), Expect = 1e-15
Identities = 68/210 (32%), Positives = 97/210 (46%), Gaps = 9/210 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL AA GH V+ LL AD +A S G AL AC GG+ V++LL+ A +
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PL +A + A+ LLE+GA + +++ L +A +G E R L
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
GA + + TAL AC D H + + LLL GA+ + + SPL A
Sbjct: 423 AGADQEHKTDEMHTALMEAC-----MDGH---VEVARLLLDSGAQVNMPADSFESPLTLA 474
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
LA LL+ GA ++ G +PL
Sbjct: 475 ACGGHVELAALLIERGASLEEVNDEGYTPL 504
Score = 80.5 bits (197), Expect = 3e-15
Identities = 57/169 (33%), Positives = 81/169 (47%), Gaps = 10/169 (5%)
Query: 155 ALHEACLGGHTACVRLLLQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRV 214
AL AC GGH V+ LL+ A + +G PL L TA +G + LL++GA ++
Sbjct: 835 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 894
Query: 215 GGTGRDTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLR 274
+DTPL +A G E L L RGA+ + RN T LS A G +
Sbjct: 895 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS--------GGYVN 946
Query: 275 LCALLLRRGAEADARDEDER--SPLHKACGHASHSLARLLLRHGADAGA 321
+ +LL GAE ++R + SPL A + + +LLL G+D A
Sbjct: 947 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINA 995
Score = 80.5 bits (197), Expect = 3e-15
Identities = 73/222 (32%), Positives = 105/222 (47%), Gaps = 29/222 (13%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPG---GRGALHEACLGGHTACVRLLLQHRADP 178
TPL +AA+ G+ ++ LL GA+ ++ G G L A + GHTA V+LLL +D
Sbjct: 934 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDI 993
Query: 179 DLLSAEGLAPLHLCR-TAASLGCAQA-------LLEHGASVQRVGGTGRDTPLHVAAQRG 230
+ A + R TA +L C Q LL+ A+V+ TG TPL AA G
Sbjct: 994 N-------AQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGL-TPLMEAASGG 1045
Query: 231 LDEHARLYLGRGAHVDARN--GRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADA 288
E R+ L +GA V+A +TAL+ A + C LL+ RGA D
Sbjct: 1046 YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGH--------YKFCELLIGRGAHIDV 1097
Query: 289 RDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPL 330
R++ +PL A + +LL++ GAD A D +PL
Sbjct: 1098 RNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1139
Score = 74.7 bits (182), Expect = 2e-13
Identities = 64/204 (31%), Positives = 89/204 (43%), Gaps = 12/204 (5%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPGGR--GALHEACLGGHTACVRLLLQHRADPD 179
TPL +AA GH V LL GAD +A L AC GG V LLL A+ +
Sbjct: 867 TPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKE 926
Query: 180 LLSAEGLAPLHLCRTAASLGCAQALLEHGASV-QRVGGTGRDTPLHVAAQRGLDEHARLY 238
+ PL L + + + LL GA + R G +PL +AA G +L
Sbjct: 927 HRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 986
Query: 239 LGRGAHVDAR-NGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPL 297
L G+ ++A+ TAL+ AC R + +LLL R A + R + +PL
Sbjct: 987 LDMGSDINAQIETNRNTALTLACFQGR--------TEVVSLLLDRKANVEHRAKTGLTPL 1038
Query: 298 HKACGHASHSLARLLLRHGADAGA 321
+A + R+LL GAD A
Sbjct: 1039 MEAASGGYAEVGRVLLDKGADVNA 1062
Score = 70.5 bits (171), Expect = 3e-12
Identities = 64/201 (31%), Positives = 89/201 (44%), Gaps = 18/201 (8%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGAD-PDASPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
+PL +AA GH L+ RGA + + G L EA GH V LLL A+ +
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGT---GRDTPLHVAAQRGLDEHARL 237
+ E TA +L C LE + + G G TPL AAQ G E +
Sbjct: 529 QTEETQ------ETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKY 582
Query: 238 YLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPL 297
L GA+V A G+TAL+ AC E+G + +LL+ GA+ + E R+PL
Sbjct: 583 LLAAGANVHATTATGDTALTYAC-------ENGH-TDVADVLLQAGADLEHESEGGRTPL 634
Query: 298 HKACGHASHSLARLLLRHGAD 318
KA + L+ GA+
Sbjct: 635 MKAARAGHVCTVQFLISKGAN 655
Score = 69.3 bits (168), Expect = 7e-12
Identities = 66/204 (32%), Positives = 94/204 (46%), Gaps = 12/204 (5%)
Query: 115 EYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQH 174
E R LT+ + A A R + + +A +L EAC G VR LL
Sbjct: 199 EVLRRLTSSVSCALDEAAAALTR--MRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIE 256
Query: 175 RADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEH 234
+ + EG + L L +A AQ LL A+V+ G G TPL AA G +
Sbjct: 257 GRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKI 316
Query: 235 ARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDER 294
+L L A V+A++ G TAL+ AC G + + +LL GA + +E+
Sbjct: 317 VKLLLAHKADVNAQSSTGNTALTYACA--------GGYVDVVKVLLESGASIEDHNENGH 368
Query: 295 SPLHKACGHASH-SLARLLLRHGA 317
+PL +A G A H +ARLLL +GA
Sbjct: 369 TPLMEA-GSAGHVEVARLLLENGA 391
Score = 62.0 bits (149), Expect = 1e-09
Identities = 64/209 (30%), Positives = 89/209 (42%), Gaps = 19/209 (9%)
Query: 115 EYKRELTTPLCIAAAHGHTACVRHLLGRGADPDA--SPGGRGALHEACLGGHTACVRLLL 172
E E TPL AA GH V LLG+GA+ +A AL AC GG L+
Sbjct: 495 EVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLI 554
Query: 173 QHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLD 232
+ AD +L + PL L + LL GA+V TG DT L A + G
Sbjct: 555 KAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG-DTALTYACENGHT 610
Query: 233 EHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCAL--LLRRGAEAD-AR 289
+ A + L GA ++ + G T L A A +C + L+ +GA +
Sbjct: 611 DVADVLLQAGADLEHESEGGRTPLMKAARAG----------HVCTVQFLISKGANVNRTT 660
Query: 290 DEDERSPLHKACGHASHSLARLLLRHGAD 318
++ + L AC ++ LLL HGAD
Sbjct: 661 ANNDHTVLSLACAGGHLAVVELLLAHGAD 689
Score = 62.0 bits (149), Expect = 1e-09
Identities = 50/140 (35%), Positives = 61/140 (43%), Gaps = 1/140 (0%)
Query: 121 TTPLCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQHRADPD 179
+TPL AA GH V++LL GA+ A+ G AL AC GHT +LLQ AD +
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Query: 180 LLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYL 239
S G PL A + Q L+ GA+V R T L +A G L L
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
Query: 240 GRGAHVDARNGRGETALSAA 259
GA R G T L A
Sbjct: 685 AHGADPTHRLKDGSTMLIEA 704
Score = 45.1 bits (105), Expect = 1e-04
Identities = 39/142 (27%), Positives = 62/142 (43%), Gaps = 16/142 (11%)
Query: 217 TGRDTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLC 276
+ DT L +A G +E + L RGA ++ R+ +G T L A A + +
Sbjct: 830 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGH--------VGVV 881
Query: 277 ALLLRRGAEADARDEDER-SPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQ 335
+LL GA+ +A+ E + +PL AC + LLL GA+ + +PL
Sbjct: 882 EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL----- 936
Query: 336 TASCALQASPQRTVQALLNHGS 357
S A ++ LLN G+
Sbjct: 937 --SLAASGGYVNIIKILLNAGA 956
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 94.0 bits (232), Expect = 3e-19
Identities = 68/215 (31%), Positives = 97/215 (45%), Gaps = 10/215 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDAS-PGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA +G LL + A PDA+ G LH A + LLL A P
Sbjct: 567 TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA 626
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ G PLH+ + A LLE+GA V G + +H+AAQ G + L LG
Sbjct: 627 AAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIAS-VHLAAQEGHVDMVSLLLG 685
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
R A+V+ N G T L A R + + +L+ +GA DA+ + +PLH
Sbjct: 686 RNANVNLSNKSGLTPLHLAAQEDR--------VNVAEVLVNQGAHVDAQTKMGYTPLHVG 737
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPLGRVLQ 335
C + + + LL+H A A G +PL + Q
Sbjct: 738 CHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQ 772
Score = 92.4 bits (228), Expect = 8e-19
Identities = 73/247 (29%), Positives = 106/247 (42%), Gaps = 43/247 (17%)
Query: 118 RELTTPLCIAAAHGHTACVRHLLGRGAD-PDASPGGRGALHEACLGGHTACVRLLLQH-- 174
R+ TPL A GH V LL R A + G LH A G H CV+LLLQH
Sbjct: 299 RDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV 358
Query: 175 -------------------------------RADPDLLSAEGLAPLHLCRTAASLGCAQA 203
+A+P+ + G PLH+ + +
Sbjct: 359 PVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMEL 418
Query: 204 LLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAA 263
LL+HGAS+Q V +G TP+HVAA G + GA + N RGETAL A +
Sbjct: 419 LLKHGASIQAVTESGL-TPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSG 477
Query: 264 RRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALD 323
+ + L++ GA+ +A+ +D+++PLH + + + LL+ GA A
Sbjct: 478 Q--------AEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT 529
Query: 324 YGGASPL 330
G +PL
Sbjct: 530 TSGYTPL 536
Score = 88.6 bits (218), Expect = 1e-17
Identities = 68/231 (29%), Positives = 105/231 (45%), Gaps = 20/231 (8%)
Query: 102 SPATFGLSGLWTLEYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEAC 160
SP G SGL TPL +AA + + LL +GA P A+ G LH A
Sbjct: 590 SPDAAGKSGL----------TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAA 639
Query: 161 LGGHTACVRLLLQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRD 220
LL++ AD + ++ +G+A +HL + LL A+V +G
Sbjct: 640 KKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL- 698
Query: 221 TPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLL 280
TPLH+AAQ A + + +GAHVDA+ G T L C H +++ LL
Sbjct: 699 TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGC--------HYGNIKIVNFLL 750
Query: 281 RRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLG 331
+ A+ +A+ ++ +PLH+A + +LL++ A L G + LG
Sbjct: 751 QHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALG 801
Score = 88.2 bits (217), Expect = 1e-17
Identities = 68/210 (32%), Positives = 95/210 (45%), Gaps = 10/210 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +A+ G+ V+ LL RGA DA G LH GH V +LL A
Sbjct: 270 TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ GL+PLH+ L C Q LL+H V V T LHVAA G + A++ L
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYL-TALHVAAHCGHYKVAKVLLD 388
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
+ A+ +A+ G T L AC R +++ LLL+ GA A E +P+H A
Sbjct: 389 KKANPNAKALNGFTPLHIACKKNR--------IKVMELLLKHGASIQAVTESGLTPIHVA 440
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
++ L+ HGA + G + L
Sbjct: 441 AFMGHVNIVSQLMHHGASPNTTNVRGETAL 470
Score = 82.0 bits (201), Expect = 1e-15
Identities = 71/237 (29%), Positives = 99/237 (41%), Gaps = 17/237 (7%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL I+A G V+ LL +GA P+A+ G LH + GH LL H A +
Sbjct: 501 TPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI 560
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ +G PLH+ L A LL+ AS G +G TPLHVAA + A L L
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGL-TPLHVAAHYDNQKVALLLLD 619
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
+GA A G T L A + + + LL GA+A+A + +H A
Sbjct: 620 QGASPHAAAKNGYTPLHIAAKKNQ--------MDIATTLLEYGADANAVTRQGIASVHLA 671
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGS 357
+ LLL A+ + G +PL A Q + L+N G+
Sbjct: 672 AQEGHVDMVSLLLGRNANVNLSNKSGLTPL-------HLAAQEDRVNVAEVLVNQGA 721
Score = 80.9 bits (198), Expect = 2e-15
Identities = 75/264 (28%), Positives = 112/264 (42%), Gaps = 44/264 (16%)
Query: 124 LCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQHRADPDLLS 182
L +A+ GH V LL R A+ DA+ G ALH A L G V++L+ + A+ + S
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137
Query: 183 AEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRG 242
G PL++ L + LL++GAS Q + TPL VA Q+G D+ L L
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTPLAVALQQGHDQVVSLLL--- 193
Query: 243 AHVDARNGRGETALSAACGAARRPDEHGRCLRL--------------------------- 275
+ +G+ L A AAR+ D L L
Sbjct: 194 ----ENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNIN 249
Query: 276 -CALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVL 334
LLL R A D ++ +PLH A + ++ +LLL GA A G +PL
Sbjct: 250 VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPL---- 305
Query: 335 QTASCALQASPQRTVQALLNHGSP 358
C ++ ++ V+ LL+ +P
Sbjct: 306 ---HCGARSGHEQVVEMLLDRAAP 326
Score = 72.4 bits (176), Expect = 8e-13
Identities = 77/242 (31%), Positives = 97/242 (40%), Gaps = 29/242 (11%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPD-ASPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA H V+ LL GA A+ G L A GH V LLL++ D
Sbjct: 142 TPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DT 197
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEH--GASVQRVGGTGRDTPLHVAAQRGLDEHARLY 238
L LH+ A LL++ A V+ G TPLH+AA G A L
Sbjct: 198 KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGF---TPLHIAAHYGNINVATLL 254
Query: 239 LGRGAHVD--ARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSP 296
L R A VD ARN +++ G A + LLL RGA+ DA+ D +P
Sbjct: 255 LNRAAAVDFTARNDITPLHVASKRGNAN----------MVKLLLDRGAKIDAKTRDGLTP 304
Query: 297 LHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHG 356
LH + +LL A + G SPL A Q VQ LL H
Sbjct: 305 LHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPL-------HMATQGDHLNCVQLLLQHN 357
Query: 357 SP 358
P
Sbjct: 358 VP 359
Score = 52.4 bits (124), Expect = 9e-07
Identities = 46/141 (32%), Positives = 59/141 (41%), Gaps = 6/141 (4%)
Query: 126 IAAAHGHTACVRHLLGRGADPDAS-PGGRGALHEACLGGHTACVRLLLQHRADPDLLSAE 184
+AA GH V LLGR A+ + S G LH A +L+ A D +
Sbjct: 670 LAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729
Query: 185 GLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRGAH 244
G PLH+ ++ LL+H A V G TPLH AAQ+G + L A
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGY-TPLHQAAQQGHTHIINVLLQNNAS 788
Query: 245 VDARNGRGETALSAACGAARR 265
+ G TAL G ARR
Sbjct: 789 PNELTVNGNTAL----GIARR 805
Score = 47.8 bits (112), Expect = 2e-05
Identities = 44/174 (25%), Positives = 69/174 (39%), Gaps = 9/174 (5%)
Query: 142 RGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDLLSAEGLAPLHLCRTAASLGCA 201
R D + A GH +++ D ++ + GL LHL +
Sbjct: 31 RSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVV 90
Query: 202 QALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACG 261
LL+ A+V G +T LH+A+ G E ++ + GA+V+A++ G T L A
Sbjct: 91 SELLQREANVDAATKKG-NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAA- 148
Query: 262 AARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRH 315
+ H L + LL GA ED +PL A + LLL +
Sbjct: 149 ----QENH---LEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN 195
Score = 43.9 bits (102), Expect = 3e-04
Identities = 34/110 (30%), Positives = 46/110 (41%), Gaps = 2/110 (1%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA L+ +GA DA G LH C G+ V LLQH A +
Sbjct: 699 TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNA 758
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRG 230
+ G PLH LL++ AS + G +T L +A + G
Sbjct: 759 KTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNG-NTALGIARRLG 807
Score = 42.4 bits (98), Expect = 0.001
Identities = 26/84 (30%), Positives = 39/84 (46%), Gaps = 1/84 (1%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL + +G+ V LL A +A + G LH+A GHT + +LLQ+ A P+
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791
Query: 181 LSAEGLAPLHLCRTAASLGCAQAL 204
L+ G L + R + L
Sbjct: 792 LTVNGNTALGIARRLGYISVVDTL 815
Score = 35.4 bits (80), Expect = 0.11
Identities = 34/132 (25%), Positives = 56/132 (42%), Gaps = 15/132 (11%)
Query: 226 AAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAE 285
AA+ G E A Y+ G ++ N G AL A + + + LL+R A
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGH--------VEVVSELLQREAN 99
Query: 286 ADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASP 345
DA + + LH A + ++L+ +GA+ A G +PL A Q +
Sbjct: 100 VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPL-------YMAAQENH 152
Query: 346 QRTVQALLNHGS 357
V+ LL++G+
Sbjct: 153 LEVVKFLLDNGA 164
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 94.0 bits (232), Expect = 3e-19
Identities = 85/298 (28%), Positives = 120/298 (40%), Gaps = 36/298 (12%)
Query: 121 TTPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRADPD 179
++PL AA G V HLL GA+ A GG LH AC GH V LLL ADP+
Sbjct: 217 SSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPN 276
Query: 180 LLSAEGLAPLHLCRTAASLGCAQALLEHGA--SVQRVGG---------------TG---R 219
PLH + LL+HGA +++ G TG +
Sbjct: 277 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKK 336
Query: 220 DTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALL 279
D L A ++ L + A +GR T L A G R +R+ LL
Sbjct: 337 DELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNR--------VRIVQLL 388
Query: 280 LRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASC 339
L+ GA+ A+D+ PLH AC + + + LLL+HGA A+D +PL
Sbjct: 389 LQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHE------- 441
Query: 340 ALQASPQRTVQALLNHGSPTVWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKE 397
A + LL+HG+ + K A P + E L + L ++ +E
Sbjct: 442 AASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAARE 499
Score = 83.2 bits (204), Expect = 5e-16
Identities = 67/220 (30%), Positives = 99/220 (45%), Gaps = 22/220 (10%)
Query: 115 EYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQ 173
E ++ TPL +AA H + L GA +A G+ ALH A L GH RLLL
Sbjct: 553 EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLS 612
Query: 174 HRADPDLLSAEGLAPLHLCRTAASLG--CAQALLEHGASVQRVGGTGRDTPLHVAAQRG- 230
+ +DP ++S +G TAA +G Q +L ++ + D L A++ G
Sbjct: 613 YGSDPSIISLQGF-------TAAQMGNEAVQQILSESTPIRT---SDVDYRLLEASKAGD 662
Query: 231 LDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARD 290
L+ +L + + GR T L A G R + + LL GA+ A+D
Sbjct: 663 LETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNR--------VSVVEYLLHHGADVHAKD 714
Query: 291 EDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPL 330
+ PLH AC + + +A LL+RHGA D +PL
Sbjct: 715 KGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPL 754
Score = 81.3 bits (199), Expect = 2e-15
Identities = 88/330 (26%), Positives = 125/330 (37%), Gaps = 54/330 (16%)
Query: 121 TTPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPD 179
+TPL AA + + V +LL GAD A GG LH AC GH LL++H A +
Sbjct: 685 STPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVN 744
Query: 180 LLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYL 239
+ PLH + LL+HGA + G +TPL + + D L
Sbjct: 745 VADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDG-NTPLDLVKEGDTDIQD-LLR 802
Query: 240 GRGAHVDARN----------------------GRGETALSAACGAARRPDEHGRCLRLCA 277
G A +DA GR T L A G L +
Sbjct: 803 GDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNN--------LEVAE 854
Query: 278 LLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQ-- 335
LL GA+ +A+D+ PLH A + +A LL+++ A D +PL Q
Sbjct: 855 YLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKG 914
Query: 336 -TASCALQASPQRTVQALLNHGSPTVWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSES 394
T CAL LL HG+ + + A+ + +L ++ P L
Sbjct: 915 RTQLCAL----------LLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTC 964
Query: 395 WKEVIPEEVFQMHKPFYQSLFALALTPRCL 424
+K P+ SL + A TP CL
Sbjct: 965 FK---PQATV-----VSASLISPASTPSCL 986
Score = 80.1 bits (196), Expect = 4e-15
Identities = 77/259 (29%), Positives = 111/259 (42%), Gaps = 35/259 (13%)
Query: 121 TTPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPD 179
+TPL +AA + V+ LL GAD A GG LH AC GH LLL+H A +
Sbjct: 370 STPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVN 429
Query: 180 LLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDE------ 233
+ PLH + + LL HGA V G+ + +A L E
Sbjct: 430 AMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSA-VDMAPTPELRERLTYEF 488
Query: 234 --HARLYLGRGAHVDA-------------RNGRGETALSAACGAARRPDEHGRCLRLCAL 278
H+ L R A + + ETAL A + H + ++ L
Sbjct: 489 KGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASL-----HPKRKQVTEL 543
Query: 279 LLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTAS 338
LLR+GA + +++D +PLH A A + + +L +HGA ALD G + L R
Sbjct: 544 LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHR------ 597
Query: 339 CALQASPQRTVQALLNHGS 357
A A +T + LL++GS
Sbjct: 598 -AALAGHLQTCRLLLSYGS 615
Score = 75.9 bits (185), Expect = 7e-14
Identities = 70/212 (33%), Positives = 86/212 (40%), Gaps = 33/212 (15%)
Query: 137 RHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDLLSAEGLAPLHLCRTAA 196
R L GR + P LH A + V LL H AD GL PLH +
Sbjct: 678 RDLEGRHSTP---------LHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYG 728
Query: 197 SLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETAL 256
A+ L+ HGASV V + TPLH AA +G E +L L GA +N G T L
Sbjct: 729 HYEVAELLVRHGASVN-VADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPL 787
Query: 257 S----------------AACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERS--PLH 298
AA A + R +LC + RD R+ PLH
Sbjct: 788 DLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCT-----PENINCRDTQGRNSTPLH 842
Query: 299 KACGHASHSLARLLLRHGADAGALDYGGASPL 330
A G+ + +A LL HGAD A D GG PL
Sbjct: 843 LAAGYNNLEVAEYLLEHGADVNAQDKGGLIPL 874
Score = 52.8 bits (125), Expect = 7e-07
Identities = 39/123 (31%), Positives = 56/123 (45%), Gaps = 8/123 (6%)
Query: 219 RDTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCAL 278
+ +PLH AA G + L GA+V AR+ G L AC + +L
Sbjct: 216 KSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGH--------AEVVSL 267
Query: 279 LLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTAS 338
LL +GA+ +ARD +PLH+A + +LL+HGAD + G S L +A
Sbjct: 268 LLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAK 327
Query: 339 CAL 341
L
Sbjct: 328 AVL 330
Score = 52.0 bits (123), Expect = 1e-06
Identities = 57/198 (28%), Positives = 81/198 (40%), Gaps = 23/198 (11%)
Query: 155 ALHEACLGGHTA---CVRLLLQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASV 211
ALH A H LLL+ A+ + + + + PLH+ A + L +HGA +
Sbjct: 525 ALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKM 584
Query: 212 QRVGGTGRDTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGR 271
+ G+ T LH AA G + RL L G+ + +G TA A ++
Sbjct: 585 NALDTLGQ-TALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSEST 643
Query: 272 CLRLCAL---LLRRGAEAD--------------ARDEDER--SPLHKACGHASHSLARLL 312
+R + LL D RD + R +PLH A G+ S+ L
Sbjct: 644 PIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYL 703
Query: 313 LRHGADAGALDYGGASPL 330
L HGAD A D GG PL
Sbjct: 704 LHHGADVHAKDKGGLVPL 721
Score = 34.3 bits (77), Expect = 0.25
Identities = 30/92 (32%), Positives = 38/92 (41%), Gaps = 3/92 (3%)
Query: 239 LGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLH 298
LG GA A G G A+S A +G R+ L+ A + SPLH
Sbjct: 165 LGPGA---AGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLH 221
Query: 299 KACGHASHSLARLLLRHGADAGALDYGGASPL 330
A G + LL+ GA+ A D GG PL
Sbjct: 222 FAAGFGRKDVVEHLLQMGANVHARDDGGLIPL 253
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 92.8 bits (229), Expect = 6e-19
Identities = 84/262 (32%), Positives = 107/262 (40%), Gaps = 12/262 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPD-ASPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA GHT V L+G GA+ + G AL A GGHT V LL D
Sbjct: 580 TPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDC 639
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
A+ L LL+HGA V + GR T L AA G E L
Sbjct: 640 ADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGR-TALIAAAYMGHREIVEHLLD 698
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
GA V+ + G TALS A H + +LL+ RGAE D D+D +PL A
Sbjct: 699 HGAEVNHEDVDGRTALSVAALCVPASKGHASVV---SLLIDRGAEVDHCDKDGMTPLLVA 755
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGSPTV 360
+ LLL GAD D G +PL A V LL G+
Sbjct: 756 AYEGHVDVVDLLLEGGADVDHTDNNGRTPL-------LAAASMGHASVVNTLLFWGAAVD 808
Query: 361 WPDAFPKVLKTCASVPAVIEVL 382
D+ + + + AS +EV+
Sbjct: 809 SIDSEGRTVLSIASAQGNVEVV 830
Score = 81.6 bits (200), Expect = 1e-15
Identities = 74/277 (26%), Positives = 118/277 (42%), Gaps = 10/277 (3%)
Query: 110 GLWTLEYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACV 168
G T E + P +A+ GH CV+ LL ++ D GR AL A L GH V
Sbjct: 870 GARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIV 929
Query: 169 RLLLQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQ 228
LL H AD + A+G L++ L A+ LE+GA+V+ GR T LHV+
Sbjct: 930 ELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGR-TALHVSCW 988
Query: 229 RGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADA 288
+G E ++ + A V+A + +AL +A +++ LL+ GA D
Sbjct: 989 QGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGH--------VKVVQLLIEHGAVVDH 1040
Query: 289 RDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRT 348
+ L A + ++LL HGAD D G + + + + ++
Sbjct: 1041 TCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKY 1100
Query: 349 VQALLNHGSPTVWPDAFPKVLKTCASVPAVIEVLFNS 385
+ LN SP+ K L++ +S + + NS
Sbjct: 1101 GASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNS 1137
Score = 78.2 bits (191), Expect = 1e-14
Identities = 74/262 (28%), Positives = 104/262 (39%), Gaps = 34/262 (12%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL AA+ GH + V LL GA D+ GR L A G+ VR LL D +
Sbjct: 783 TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
G PLH+ +AL+E GA + GR P +A+Q G + ++ L
Sbjct: 843 RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGR-IPFILASQEGHYDCVQILLE 901
Query: 241 RGAHVDARNGRGETALSAACGAARR---------------PDEHGR----------CLRL 275
+++D R G AL A R D GR L +
Sbjct: 902 NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTM 961
Query: 276 CALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQ 335
L GA +A D + R+ LH +C + ++L+ + AD A D S L
Sbjct: 962 AEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSAL----- 1016
Query: 336 TASCALQASPQRTVQALLNHGS 357
S A Q + VQ L+ HG+
Sbjct: 1017 -QSAAWQGH-VKVVQLLIEHGA 1036
Score = 69.3 bits (168), Expect = 7e-12
Identities = 62/210 (29%), Positives = 84/210 (40%), Gaps = 10/210 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AA GH V LL GAD D + GR L A GH + V LL A D
Sbjct: 750 TPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDS 809
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ +EG L + ++ + LL+ G G TPLH+AA G +
Sbjct: 810 IDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGW-TPLHMAAFEGHRLICEALIE 868
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
+GA + + G A + H C++ +LL + D R D R+ L A
Sbjct: 869 QGARTNEIDNDGRIPFILA-----SQEGHYDCVQ---ILLENKSNIDQRGYDGRNALRVA 920
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
+ LL HGAD D G L
Sbjct: 921 ALEGHRDIVELLFSHGADVNCKDADGRPTL 950
Score = 58.9 bits (141), Expect = 9e-09
Identities = 61/219 (27%), Positives = 81/219 (36%), Gaps = 13/219 (5%)
Query: 136 VRHLLGRGADPD-ASPGGRGALHEACLGGHTACVRLLLQHRADPDLLSAEGLAPLHLCRT 194
+R LL GA + GR L A G V LL+ AD ++ A G PL L
Sbjct: 528 IRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAAR 587
Query: 195 AASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGET 254
L+ GA++ G T L AA G E L G VD + T
Sbjct: 588 QGHTKVVNCLIGCGANINHTDQDGW-TALRSAAWGGHTEVVSALLYAGVKVDCADADSRT 646
Query: 255 ALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLR 314
AL AA + LL+ GAE + D + R+ L A + LL
Sbjct: 647 ALRAAAWGGHED--------IVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLD 698
Query: 315 HGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALL 353
HGA+ D G + L A C + +V +LL
Sbjct: 699 HGAEVNHEDVDGRTALS---VAALCVPASKGHASVVSLL 734
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 91.7 bits (226), Expect = 1e-18
Identities = 73/210 (34%), Positives = 91/210 (43%), Gaps = 10/210 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL A G VR LL D D + G L A LLL H AD +
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ +G APLH G A+ LL+HGA V G TPLH+AAQ + ARL +
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGW-TPLHLAAQNNFENVARLLVS 482
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
R A + G+T L A + L LL +GAE DA+ + R+PLH A
Sbjct: 483 RQADPNLHEAEGKTPLHVAAYFGH--------VSLVKLLTSQGAELDAQQRNLRTPLHLA 534
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
+ LL+ GA ALD G PL
Sbjct: 535 VERGKVRAIQHLLKSGAVPDALDQSGYGPL 564
Score = 85.9 bits (211), Expect = 7e-17
Identities = 71/210 (33%), Positives = 90/210 (42%), Gaps = 10/210 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPD-ASPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL IAA LL GAD + G LH A G RLLL H A D
Sbjct: 397 TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDA 456
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
EG PLHL A+ L+ A G+ TPLHVAA G +L
Sbjct: 457 QEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGK-TPLHVAAYFGHVSLVKLLTS 515
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
+GA +DA+ T L A E G+ +R LL+ GA DA D+ PLH A
Sbjct: 516 QGAELDAQQRNLRTPLHLAV-------ERGK-VRAIQHLLKSGAVPDALDQSGYGPLHTA 567
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
+ + ++LLR+GA + G +PL
Sbjct: 568 AARGKYLICKMLLRYGASLELPTHQGWTPL 597
Score = 80.9 bits (198), Expect = 2e-15
Identities = 68/223 (30%), Positives = 96/223 (43%), Gaps = 10/223 (4%)
Query: 117 KRELTTPLCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQHR 175
+RE TPL +AA + R L+ R ADP+ G+ LH A GH + V+LL
Sbjct: 458 EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQG 517
Query: 176 ADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHA 235
A+ D PLHL + Q LL+ GA + +G PLH AA RG
Sbjct: 518 AELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYG-PLHTAAARGKYLIC 576
Query: 236 RLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERS 295
++ L GA ++ +G T L A L + LL A A +
Sbjct: 577 KMLLRYGASLELPTHQGWTPLHLAAYKGH--------LEIIHLLAESHANMGALGAVNWT 628
Query: 296 PLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTAS 338
PLH A H ++ LL+ GAD A + G +PL +Q ++
Sbjct: 629 PLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRST 671
Score = 78.6 bits (192), Expect = 1e-14
Identities = 67/222 (30%), Positives = 98/222 (44%), Gaps = 12/222 (5%)
Query: 117 KRELTTPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHR 175
+R L TPL +A G ++HLL GA PDA G G LH A G ++LL++
Sbjct: 524 QRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYG 583
Query: 176 ADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHA 235
A +L + +G PLHL L L E A++ +G TPLH+AA+ G +
Sbjct: 584 ASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNW-TPLHLAARHGEEAVV 642
Query: 236 RLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCAL-LLRRGAEADARDEDER 294
L GA +A G T L A R L + LL A AR++
Sbjct: 643 SALLQCGADPNAAEQSGWTPLHLAV---------QRSTFLSVINLLEHHANVHARNKVGW 693
Query: 295 SPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQT 336
+P H A + ++ ++L+ GA D +PL L++
Sbjct: 694 TPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRS 735
Score = 77.4 bits (189), Expect = 3e-14
Identities = 68/215 (31%), Positives = 100/215 (46%), Gaps = 10/215 (4%)
Query: 116 YKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPGG-RGALHEACLGGHTACVRLLLQH 174
++ E TPL +AA GH + V+ L +GA+ DA R LH A G ++ LL+
Sbjct: 490 HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS 549
Query: 175 RADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEH 234
A PD L G PLH + LL +GAS++ G TPLH+AA +G E
Sbjct: 550 GAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW-TPLHLAAYKGHLEI 608
Query: 235 ARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDER 294
L A++ A T L AAR +E + + LL+ GA+ +A ++
Sbjct: 609 IHLLAESHANMGALGAVNWTPLHL---AARHGEE-----AVVSALLQCGADPNAAEQSGW 660
Query: 295 SPLHKACGHASHSLARLLLRHGADAGALDYGGASP 329
+PLH A ++ LL H A+ A + G +P
Sbjct: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTP 695
Score = 37.4 bits (85), Expect = 0.029
Identities = 35/130 (26%), Positives = 48/130 (36%), Gaps = 34/130 (26%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPG------------------------------ 151
TPL +AA HG A V LL GADP+A+
Sbjct: 628 TPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHA 687
Query: 152 ----GRGALHEACLGGHTACVRLLLQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEH 207
G H A L G+TA +++L++ A D+ PL L + G L
Sbjct: 688 RNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGK 747
Query: 208 GASVQRVGGT 217
SV +GG+
Sbjct: 748 EPSVATLGGS 757
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 87.4 bits (215), Expect = 2e-17
Identities = 71/214 (33%), Positives = 92/214 (42%), Gaps = 13/214 (6%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL ++ +GHT CV LL +GA+ DA GR ALH + GH CV LLQH A L
Sbjct: 655 TPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLL 714
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRD---TPLHVAAQRGLDEHARL 237
+ G P+HL +G ALL+ AS+ T + T LH A G + L
Sbjct: 715 RDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVEL 774
Query: 238 YLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAE-ADARDEDERSP 296
L + + G C D G L L GA +A D R+P
Sbjct: 775 LLEQEVF---QKTEGNAFSPLHCAVIN--DNEGAAEMLIDTL---GASIVNATDSKGRTP 826
Query: 297 LHKACGHASHSLARLLLRHGADAGALDYGGASPL 330
LH A +LLL H A ++D G +PL
Sbjct: 827 LHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPL 860
Score = 85.1 bits (209), Expect = 1e-16
Identities = 76/221 (34%), Positives = 97/221 (43%), Gaps = 21/221 (9%)
Query: 123 PLCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQHRADPDLL 181
PL +AA G + C R LL G D D GR LH A GG+ C+ LLL AD +
Sbjct: 375 PLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKK 434
Query: 182 SAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGR 241
G +PLH + C AL+ GASV + G TPLH AA D YL R
Sbjct: 435 DKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERG-CTPLHYAATSDTDGKCLEYLLR 493
Query: 242 G-AHVDARNGRGETAL--SAACGAARRPDEHGRCLRLCA------LLLRRGAEADARDED 292
A+ R+ +G A+ SAA G H CL+L A +L+ D D
Sbjct: 494 NDANPGIRDKQGYNAVHYSAAYG-------HRLCLQLIASETPLDVLMETSGTDMLSDSD 546
Query: 293 ER---SPLHKACGHASHSLARLLLRHGADAGALDYGGASPL 330
R SPLH A H H +L++ D + G +PL
Sbjct: 547 NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPL 587
Score = 79.3 bits (194), Expect = 7e-15
Identities = 69/247 (27%), Positives = 106/247 (42%), Gaps = 37/247 (14%)
Query: 127 AAAHGHTACVRHLLGR----------GADPDASPGGRGA---LHEACLGGHTACVRLLLQ 173
+AA+GH C++ + G D + R LH A GH + +L+Q
Sbjct: 512 SAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQ 571
Query: 174 HRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDE 233
D D+ ++ G PL L + C L+ GAS+ + TP+H AA G E
Sbjct: 572 SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSE 631
Query: 234 HARLYLGRGA---HVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARD 290
RL +G VD ++G G+T L + + H C+ LL +GA DA+D
Sbjct: 632 CLRLLIGNAEPQNAVDIQDGNGQTPLMLSV-----LNGHTDCV---YSLLNKGANVDAKD 683
Query: 291 EDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASP------------LGRVLQTAS 338
+ R+ LH+ LL+HGA D G +P LG +LQ+A+
Sbjct: 684 KWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAA 743
Query: 339 CALQASP 345
++ A+P
Sbjct: 744 -SMDANP 749
Score = 76.3 bits (186), Expect = 6e-14
Identities = 67/244 (27%), Positives = 100/244 (40%), Gaps = 44/244 (18%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLL-------- 172
TPL IAAA+ C L+ ++ + S GR ALH A GH V+LLL
Sbjct: 109 TPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINA 168
Query: 173 -------------------------QHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEH 207
H A+ + PLH ++ + + LL+
Sbjct: 169 FDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDL 228
Query: 208 GASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPD 267
G + G +TPLHVA G D + GA V+ +N +G T L A +
Sbjct: 229 GVDMNEPNAYG-NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAAST---- 283
Query: 268 EHGR-CLRLCALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGG 326
HG CL LL+ GA+ + + +D ++PLH H S ++ +++ GA D G
Sbjct: 284 -HGALCLE---LLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNG 339
Query: 327 ASPL 330
+PL
Sbjct: 340 NTPL 343
Score = 74.7 bits (182), Expect = 2e-13
Identities = 63/213 (29%), Positives = 94/213 (44%), Gaps = 10/213 (4%)
Query: 119 ELTTPLCIAAAHGHTACVRHLLGRGADPDASPGG-RGALHEACLGGHTACVRLLLQHRAD 177
E TPL AA G + L+ GA +A LH A V++LL+H AD
Sbjct: 40 EKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSAD 99
Query: 178 PDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARL 237
+ PLH+ ++ CA+AL+ ++V GR T LH AA G E +L
Sbjct: 100 VNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGR-TALHHAAFSGHGEMVKL 158
Query: 238 YLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPL 297
L RGA+++A + + A+ A + + LL+ GAE +D+ +PL
Sbjct: 159 LLSRGANINAFDKKDRRAIHWAAYMGH--------IEVVKLLVSHGAEVTCKDKKSYTPL 210
Query: 298 HKACGHASHSLARLLLRHGADAGALDYGGASPL 330
H A S+ + LL G D + G +PL
Sbjct: 211 HAAASSGMISVVKYLLDLGVDMNEPNAYGNTPL 243
Score = 73.9 bits (180), Expect = 3e-13
Identities = 73/270 (27%), Positives = 108/270 (40%), Gaps = 63/270 (23%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADP-DASPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL AA+ G + V++LL G D + + G LH AC G V L+ A +
Sbjct: 208 TPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQ 267
Query: 181 LSAEGLAPLHLCRTAASLG--CAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLY 238
+ +G PLH A++ G C + L+ +GA V G+ TPLH+ A G ++
Sbjct: 268 KNEKGFTPLHFA-AASTHGALCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFSRSQTI 325
Query: 239 LGRGAHVDARNGRGETAL----------------SAACGAARR----------------- 265
+ GA +D + G T L ++ A+R
Sbjct: 326 IQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFS 385
Query: 266 ---------------PDEHGR-CLRLCA---------LLLRRGAEADARDEDERSPLHKA 300
PD+ GR CL A LLL GA+ + +D+ RSPLH A
Sbjct: 386 DCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYA 445
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
+ ++ L+ GA LD G +PL
Sbjct: 446 AANCNYQCLFALVGSGASVNDLDERGCTPL 475
Score = 73.9 bits (180), Expect = 3e-13
Identities = 68/204 (33%), Positives = 88/204 (43%), Gaps = 24/204 (11%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPG--GRGALHEACLGGHTACVRLLLQHRADP- 178
TPL +AA GH CV L+ +GA R +H A GH+ C+RLL+ + A+P
Sbjct: 585 TPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGN-AEPQ 643
Query: 179 ---DLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHA 235
D+ G PL L C +LL GA+V GR T LH A G +E
Sbjct: 644 NAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGR-TALHRGAVTGHEECV 702
Query: 236 RLYLGRGAHVDARNGRGETA--LSAACGAARRPDEHGRCLRLCALLLRRGAEADAR---- 289
L GA R+ RG T LSAACG + + LL+ A DA
Sbjct: 703 DALLQHGAKCLLRDSRGRTPIHLSAACGH----------IGVLGALLQSAASMDANPATA 752
Query: 290 DEDERSPLHKACGHASHSLARLLL 313
D + LH AC + + LLL
Sbjct: 753 DNHGYTALHWACYNGHETCVELLL 776
Score = 71.2 bits (173), Expect = 2e-12
Identities = 63/193 (32%), Positives = 83/193 (43%), Gaps = 11/193 (5%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPGGRGA--LHEACLGGHTACVRLLLQHRADPD 179
TPL IAA +GH + L+ GAD A G G LH A L G + C R LL D D
Sbjct: 341 TPLHIAARYGHELLINTLITSGADT-AKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDID 399
Query: 180 LLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYL 239
G LH +L C LL GA + GR +PLH AA + +
Sbjct: 400 TPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGR-SPLHYAAANCNYQCLFALV 458
Query: 240 GRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHK 299
G GA V+ + RG T L A + D G+CL LLR A RD+ + +H
Sbjct: 459 GSGASVNDLDERGCTPLHYAATS----DTDGKCLE---YLLRNDANPGIRDKQGYNAVHY 511
Query: 300 ACGHASHSLARLL 312
+ + +L+
Sbjct: 512 SAAYGHRLCLQLI 524
Score = 71.2 bits (173), Expect = 2e-12
Identities = 69/248 (27%), Positives = 96/248 (38%), Gaps = 46/248 (18%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPG-----GRGALHEACLGGHTACVRLLLQHRA 176
TP+ ++AA GH + LL A DA+P G ALH AC GH CV LLL+
Sbjct: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV 780
Query: 177 DP--------------------------DLLSA--------EGLAPLHLCRTAASLGCAQ 202
D L A +G PLH + C Q
Sbjct: 781 FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQ 840
Query: 203 ALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYL-GRGAHVDARNGRGETALSAACG 261
LL H A V V TG+ TPL +AA+ G + + A + ++ TAL AC
Sbjct: 841 LLLSHNAQVNSVDSTGK-TPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACS 899
Query: 262 AARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGA 321
L + + R +A + ++PLH A + + + LL GA A
Sbjct: 900 KGHETS----ALLILEKITDRNL-INATNAALQTPLHVAARNGLTMVVQELLGKGASVLA 954
Query: 322 LDYGGASP 329
+D G +P
Sbjct: 955 VDENGYTP 962
Score = 44.3 bits (103), Expect = 2e-04
Identities = 39/123 (31%), Positives = 53/123 (43%), Gaps = 5/123 (4%)
Query: 122 TPLCIAAAHGHTACVRHLLGRG-ADPDASPGGRG-ALHEACLGGHTACVRLLLQHRADPD 179
TPL +AA +G T V L+ A+ + ALH AC GH L+L+ D +
Sbjct: 858 TPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRN 917
Query: 180 LLSAEGLA---PLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHAR 236
L++A A PLH+ Q LL GASV V G L A + + +
Sbjct: 918 LINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLA 977
Query: 237 LYL 239
L L
Sbjct: 978 LIL 980
Score = 37.0 bits (84), Expect = 0.038
Identities = 25/79 (31%), Positives = 40/79 (50%), Gaps = 7/79 (8%)
Query: 279 LLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTAS 338
L+ + + + +D ++R+PLH A + LL+ GA A D +PL R + AS
Sbjct: 27 LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAV--AS 84
Query: 339 CALQASPQRTVQALLNHGS 357
C+ +A VQ LL H +
Sbjct: 85 CSEEA-----VQVLLKHSA 98
Score = 29.3 bits (64), Expect = 8.0
Identities = 14/25 (56%), Positives = 18/25 (72%)
Query: 120 LTTPLCIAAAHGHTACVRHLLGRGA 144
L TPL +AA +G T V+ LLG+GA
Sbjct: 926 LQTPLHVAARNGLTMVVQELLGKGA 950
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 86.7 bits (213), Expect = 4e-17
Identities = 71/239 (29%), Positives = 101/239 (42%), Gaps = 34/239 (14%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP-GGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL +AAA+ C ++ + + S GGR ALH A L GH V LLL A+ +
Sbjct: 84 TPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINA 143
Query: 181 LSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLG 240
+ LH L L+ HGA V G TPLH AA G + L
Sbjct: 144 FDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGY-TPLHAAASNGQINVVKHLLN 202
Query: 241 RGAHVDARNGRGETALSAAC--------------GA-ARRPDEHG--------------R 271
G +D N G TAL AC GA +P+ +G
Sbjct: 203 LGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGAL 262
Query: 272 CLRLCALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPL 330
CL LL+ GA+ + + +D +SPLH H + ++ L+++G + +D G +PL
Sbjct: 263 CLE---LLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPL 318
Score = 77.0 bits (188), Expect = 3e-14
Identities = 70/237 (29%), Positives = 99/237 (41%), Gaps = 30/237 (12%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQHRADPDL 180
TPL AA++G V+HLL G + D + G ALH AC G A V L+ + A+ +
Sbjct: 183 TPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQ 242
Query: 181 LSAEGLAPLHLCRTAASLG--CAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLY 238
+ G PLH A++ G C + L+ +GA V G+ +PLH+ A G ++
Sbjct: 243 PNNNGFTPLHFA-AASTHGALCLELLVNNGADVNIQSKDGK-SPLHMTAVHGRFTRSQTL 300
Query: 239 LGRGAHVDARNGRGETAL---------------------SAACGAARRPDEHGRCLR--- 274
+ G +D + G T L +A CG H L
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360
Query: 275 -LCALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPL 330
C LL G E D D+ R+ LH A + +LL GAD D G +PL
Sbjct: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPL 417
Score = 73.9 bits (180), Expect = 3e-13
Identities = 65/199 (32%), Positives = 90/199 (45%), Gaps = 15/199 (7%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPG--GRGALHEACLGGHTACVRLLLQHRADP- 178
T L +AA GHT CV L+ GA R LH + + GHT C+RLLL+ +P
Sbjct: 577 TALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPE 636
Query: 179 --DLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHAR 236
D+ A+G PL L + LLE A+V V G T LH G +E +
Sbjct: 637 AVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILG-CTALHRGIMTGHEECVQ 695
Query: 237 LYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADA--RDEDER 294
+ L + + ++ RG T L A AAR G L LL +E D +D
Sbjct: 696 MLLEQEVSILCKDSRGRTPLHYA--AAR-----GHATWLSELLQMALSEEDCCFKDNQGY 748
Query: 295 SPLHKACGHASHSLARLLL 313
+PLH AC + + + +LL
Sbjct: 749 TPLHWACYNGNENCIEVLL 767
Score = 73.2 bits (178), Expect = 5e-13
Identities = 60/213 (28%), Positives = 95/213 (44%), Gaps = 10/213 (4%)
Query: 119 ELTTPLCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQHRAD 177
E TPL +AA G + L+ GA +A LH A V++L++H AD
Sbjct: 15 EKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSAD 74
Query: 178 PDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARL 237
+ PLH+ ++ CA+ ++ +SV V G T LH AA G E L
Sbjct: 75 VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSV-NVSDRGGRTALHHAALNGHVEMVNL 133
Query: 238 YLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPL 297
L +GA+++A + + AL A L + ALL+ GAE +D+ +PL
Sbjct: 134 LLAKGANINAFDKKDRRALHWAAYMGH--------LDVVALLINHGAEVTCKDKKGYTPL 185
Query: 298 HKACGHASHSLARLLLRHGADAGALDYGGASPL 330
H A + ++ + LL G + ++ G + L
Sbjct: 186 HAAASNGQINVVKHLLNLGVEIDEINVYGNTAL 218
Score = 71.2 bits (173), Expect = 2e-12
Identities = 79/283 (27%), Positives = 105/283 (37%), Gaps = 45/283 (15%)
Query: 123 PLCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEACLGGHTACVRLLLQHRADPDLL 181
PL +AA + H+ C R LL G + D GR LH A GG+ C++LL AD
Sbjct: 350 PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409
Query: 182 SAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLD--------- 232
G PLH C + L+ GA+V GR T LH AA +D
Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGR-TALHYAAASDMDRNKTILGNA 468
Query: 233 -------EHAR------------LYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCL 273
E AR L A+ R+ G ++ A H +CL
Sbjct: 469 HDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYG-----HRQCL 523
Query: 274 RLCALLLRRGAEADARDED-ERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGR 332
L LL R + + D +SPLH A + H +LL+ D D G + L
Sbjct: 524 EL--LLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTAL-- 579
Query: 333 VLQTASCALQASPQRTVQALLNHGSPTVWPDAFPKVLKTCASV 375
A V+AL+N G+ D K ASV
Sbjct: 580 -----DLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASV 617
Score = 68.6 bits (166), Expect = 1e-11
Identities = 74/245 (30%), Positives = 98/245 (40%), Gaps = 40/245 (16%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDA----SPGGRGALHEACLGGHTACVRLLLQHRAD 177
TPL + +GHT C+R LL +P+A G+ L A GH V LLL+ A+
Sbjct: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670
Query: 178 PDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRG----LDE 233
D + G LH C Q LLE S+ GR TPLH AA RG L E
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGR-TPLHYAAARGHATWLSE 729
Query: 234 HARLYLGRGAHVDARNGRGETALSAAC---------------------GAARRP------ 266
++ L ++ +G T L AC G P
Sbjct: 730 LLQMALSE-EDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAII 788
Query: 267 DEHGRCLRLCALLLRRGAEADARDEDERSPLHKACGHASH-SLARLLLRHGADAGALDYG 325
++HG C L + RD+ R+PL +A A H +LLLRH A A+D
Sbjct: 789 NDHGNCASLLLGAIDSSI-VSCRDDKGRTPL-RAAAFADHVECLQLLLRHSAPVNAVDNS 846
Query: 326 GASPL 330
G + L
Sbjct: 847 GKTAL 851
Score = 67.8 bits (164), Expect = 2e-11
Identities = 58/210 (27%), Positives = 83/210 (39%), Gaps = 14/210 (6%)
Query: 127 AAAHGHTACVRHLLGR---GADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDLLSA 183
AAA+GH C+ LL R G + S + LH A GH + +LLQ D D+
Sbjct: 514 AAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDE 573
Query: 184 EGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYL---G 240
+G L L C +AL+ GAS+ + TPLH + G RL L
Sbjct: 574 KGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIAD 633
Query: 241 RGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKA 300
VD ++ +G+T L A + +LLL + A D D + LH+
Sbjct: 634 NPEAVDVKDAKGQTPLMLAVAYGH--------IDAVSLLLEKEANVDTVDILGCTALHRG 685
Query: 301 CGHASHSLARLLLRHGADAGALDYGGASPL 330
++LL D G +PL
Sbjct: 686 IMTGHEECVQMLLEQEVSILCKDSRGRTPL 715
Score = 63.9 bits (154), Expect = 3e-10
Identities = 72/274 (26%), Positives = 103/274 (37%), Gaps = 59/274 (21%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASPG-GRGALHEAC----------LGGH------ 164
TPL AAA+ H C+ L+ GA+ + + GR ALH A LG
Sbjct: 415 TPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEE 474
Query: 165 ------------TACVRLLLQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQ 212
T C+ LLQ+ A+P + EG +H C + LLE S
Sbjct: 475 LERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGF 534
Query: 213 RVGGTGRD-TPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAAC----------- 260
+G +PLH+AA G + + L +D R+ +G TAL A
Sbjct: 535 EESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594
Query: 261 ---GAA---------RRP------DEHGRCLRLCALLLRRGAEADARDEDERSPLHKACG 302
GA+ R P + H CLRL + D +D ++PL A
Sbjct: 595 INPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVA 654
Query: 303 HASHSLARLLLRHGADAGALDYGGASPLGRVLQT 336
+ LLL A+ +D G + L R + T
Sbjct: 655 YGHIDAVSLLLEKEANVDTVDILGCTALHRGIMT 688
Score = 61.6 bits (148), Expect = 1e-09
Identities = 59/199 (29%), Positives = 81/199 (40%), Gaps = 17/199 (8%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPD----ASPGGRGALHEACLGGHTACVRLLLQHRAD 177
TPL AAA GH + LL + G LH AC G+ C+ +LL+ +
Sbjct: 713 TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCF 772
Query: 178 PDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRD---TPLHVAAQRGLDEH 234
+ PLH CA LL GA + D TPL AA E
Sbjct: 773 RKFIG-NPFTPLHCAIINDHGNCASLLL--GAIDSSIVSCRDDKGRTPLRAAAFADHVEC 829
Query: 235 ARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDER 294
+L L A V+A + G+TAL A E+G+ + L+ A+ +D+D
Sbjct: 830 LQLLLRHSAPVNAVDNSGKTALMMAA-------ENGQAGAVDILVNSAQADLTVKDKDLN 882
Query: 295 SPLHKACGHASHSLARLLL 313
+PLH AC A L+L
Sbjct: 883 TPLHLACSKGHEKCALLIL 901
Score = 47.8 bits (112), Expect = 2e-05
Identities = 35/123 (28%), Positives = 50/123 (40%), Gaps = 3/123 (2%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDAS---PGGRGALHEACLGGHTACVRLLLQHRADP 178
TPL A + H C LLG S GR L A H C++LLL+H A
Sbjct: 781 TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPV 840
Query: 179 DLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLY 238
+ + G L + G L+ + V +TPLH+A +G ++ A L
Sbjct: 841 NAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLI 900
Query: 239 LGR 241
L +
Sbjct: 901 LDK 903
Score = 35.0 bits (79), Expect = 0.15
Identities = 21/80 (26%), Positives = 37/80 (46%), Gaps = 7/80 (8%)
Query: 278 LLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTA 337
+L+ + + + D ++R+PLH A + LL+ GA A D +PL R + +
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 338 SCALQASPQRTVQALLNHGS 357
S + VQ L+ H +
Sbjct: 61 S-------EEAVQVLIKHSA 73
>gi|38176283 ankyrin repeat and SOCS box-containing protein 7
isoform 2 [Homo sapiens]
Length = 318
Score = 85.1 bits (209), Expect = 1e-16
Identities = 77/245 (31%), Positives = 104/245 (42%), Gaps = 33/245 (13%)
Query: 115 EYKRELTTPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQ 173
E + EL +AA HT VR +L +G P+ G LH + G CVR+ L+
Sbjct: 11 ELQEELQIQAAVAAGDVHT--VRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLE 68
Query: 174 HRADP---DLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRD--TPLHVAAQ 228
H ADP DL+ G LH A+ +LE + D TPLHVAA
Sbjct: 69 HGADPTVKDLIG--GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAH 126
Query: 229 RGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPD-------------EHGRCLRL 275
G D RL L A VD + +G T L A R ++G LR
Sbjct: 127 YGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRY 186
Query: 276 ---------CALLLRRGAEAD-ARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYG 325
C + L+RGA+ + R ED ++PLH + AR+L +GAD +Y
Sbjct: 187 AVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYE 246
Query: 326 GASPL 330
G +PL
Sbjct: 247 GQTPL 251
Score = 55.5 bits (132), Expect = 1e-07
Identities = 61/215 (28%), Positives = 79/215 (36%), Gaps = 70/215 (32%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP--GGRGALHEACLGG---------------- 163
T L +AA G CVR L GADP GG ALH A + G
Sbjct: 49 TLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSD 108
Query: 164 -------------HTAC-------VRLLLQHRADPDLLSAEGLAPLHLCRTAASLGCAQA 203
H A VRLLL+ +A+ D LS +G PL L C +
Sbjct: 109 IINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKI 168
Query: 204 LLEHGASVQRVGG--------------------------TGR----DTPLHVAAQRGLDE 233
LL+H A++ G GR TPLH++A R
Sbjct: 169 LLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVL 228
Query: 234 HARLYLGRGAHVDARNGRGET--ALSAACGAARRP 266
AR+ GA + RN G+T A+S + + RP
Sbjct: 229 CARMLYNYGADTNTRNYEGQTPLAVSISISGSSRP 263
>gi|30089994 ankyrin repeat and SOCS box-containing protein 7
isoform 1 [Homo sapiens]
Length = 274
Score = 85.1 bits (209), Expect = 1e-16
Identities = 77/245 (31%), Positives = 104/245 (42%), Gaps = 33/245 (13%)
Query: 115 EYKRELTTPLCIAAAHGHTACVRHLLGRGADPDA-SPGGRGALHEACLGGHTACVRLLLQ 173
E + EL +AA HT VR +L +G P+ G LH + G CVR+ L+
Sbjct: 11 ELQEELQIQAAVAAGDVHT--VRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLE 68
Query: 174 HRADP---DLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRD--TPLHVAAQ 228
H ADP DL+ G LH A+ +LE + D TPLHVAA
Sbjct: 69 HGADPTVKDLIG--GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAH 126
Query: 229 RGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPD-------------EHGRCLRL 275
G D RL L A VD + +G T L A R ++G LR
Sbjct: 127 YGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRY 186
Query: 276 ---------CALLLRRGAEAD-ARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYG 325
C + L+RGA+ + R ED ++PLH + AR+L +GAD +Y
Sbjct: 187 AVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYE 246
Query: 326 GASPL 330
G +PL
Sbjct: 247 GQTPL 251
Score = 55.5 bits (132), Expect = 1e-07
Identities = 61/215 (28%), Positives = 79/215 (36%), Gaps = 70/215 (32%)
Query: 122 TPLCIAAAHGHTACVRHLLGRGADPDASP--GGRGALHEACLGG---------------- 163
T L +AA G CVR L GADP GG ALH A + G
Sbjct: 49 TLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSD 108
Query: 164 -------------HTAC-------VRLLLQHRADPDLLSAEGLAPLHLCRTAASLGCAQA 203
H A VRLLL+ +A+ D LS +G PL L C +
Sbjct: 109 IINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKI 168
Query: 204 LLEHGASVQRVGG--------------------------TGR----DTPLHVAAQRGLDE 233
LL+H A++ G GR TPLH++A R
Sbjct: 169 LLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVL 228
Query: 234 HARLYLGRGAHVDARNGRGET--ALSAACGAARRP 266
AR+ GA + RN G+T A+S + + RP
Sbjct: 229 CARMLYNYGADTNTRNYEGQTPLAVSISISGSSRP 263
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,361,794
Number of Sequences: 37866
Number of extensions: 1002009
Number of successful extensions: 6564
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 307
Number of HSP's successfully gapped in prelim test: 55
Number of HSP's that attempted gapping in prelim test: 2328
Number of HSP's gapped (non-prelim): 1634
length of query: 466
length of database: 18,247,518
effective HSP length: 106
effective length of query: 360
effective length of database: 14,233,722
effective search space: 5124139920
effective search space used: 5124139920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.