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Search of human proteins with 157504499
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157504499 ankyrin repeat domain 47 [Homo sapiens]
(821 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157504499 ankyrin repeat domain 47 [Homo sapiens] 1610 0.0
gi|209969812 ankyrin repeat domain 25 [Homo sapiens] 376 e-104
gi|31324547 ankyrin repeat domain 25 [Homo sapiens] 376 e-104
gi|23510377 KN motif and ankyrin repeat domains 1 isoform b [Hom... 292 8e-79
gi|64464726 KN motif and ankyrin repeat domains 1 isoform a [Hom... 292 8e-79
gi|156104862 ankyrin repeat domain 38 [Homo sapiens] 258 1e-68
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 73 1e-12
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 69 1e-11
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 69 1e-11
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 69 2e-11
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 69 2e-11
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 69 2e-11
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 69 2e-11
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 66 1e-10
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 65 2e-10
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 65 3e-10
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 65 3e-10
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 64 4e-10
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 64 4e-10
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 64 6e-10
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 64 7e-10
gi|222537750 ankyrin repeat domain 30B [Homo sapiens] 63 1e-09
gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo... 63 1e-09
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 63 1e-09
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 63 1e-09
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 63 1e-09
gi|10863929 ribonuclease L [Homo sapiens] 63 1e-09
gi|134244285 Notch homolog 3 [Homo sapiens] 62 2e-09
gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens] 62 2e-09
gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo... 62 2e-09
>gi|157504499 ankyrin repeat domain 47 [Homo sapiens]
Length = 821
Score = 1610 bits (4169), Expect = 0.0
Identities = 821/821 (100%), Positives = 821/821 (100%)
Query: 1 MAKFALNQNLPDLGGPRLCPVPAAGGARSPSSPYSVETPYGFHLDLDFLKYIEELERGPA 60
MAKFALNQNLPDLGGPRLCPVPAAGGARSPSSPYSVETPYGFHLDLDFLKYIEELERGPA
Sbjct: 1 MAKFALNQNLPDLGGPRLCPVPAAGGARSPSSPYSVETPYGFHLDLDFLKYIEELERGPA 60
Query: 61 ARRAPGPPTSRRPRAPRPGLAGARSPGAWTSSESLASDDGGAPGILSQGAPSGLLMQPLS 120
ARRAPGPPTSRRPRAPRPGLAGARSPGAWTSSESLASDDGGAPGILSQGAPSGLLMQPLS
Sbjct: 61 ARRAPGPPTSRRPRAPRPGLAGARSPGAWTSSESLASDDGGAPGILSQGAPSGLLMQPLS 120
Query: 121 PRAPVRNPRVEHTLRETSRRLELAQTHERAPSPGRGVPRSPRGSGRSSPAPNLAPASPGP 180
PRAPVRNPRVEHTLRETSRRLELAQTHERAPSPGRGVPRSPRGSGRSSPAPNLAPASPGP
Sbjct: 121 PRAPVRNPRVEHTLRETSRRLELAQTHERAPSPGRGVPRSPRGSGRSSPAPNLAPASPGP 180
Query: 181 AQLQLVREQMAAALRRLRELEDQARTLPELQEQVRALRAEKARLLAGRAQPEPDGEAETR 240
AQLQLVREQMAAALRRLRELEDQARTLPELQEQVRALRAEKARLLAGRAQPEPDGEAETR
Sbjct: 181 AQLQLVREQMAAALRRLRELEDQARTLPELQEQVRALRAEKARLLAGRAQPEPDGEAETR 240
Query: 241 PDKLAQLRRLTERLATSERGGRARASPRADSPDGLAAGRSEGALQVLDGEVGSLDGTPQT 300
PDKLAQLRRLTERLATSERGGRARASPRADSPDGLAAGRSEGALQVLDGEVGSLDGTPQT
Sbjct: 241 PDKLAQLRRLTERLATSERGGRARASPRADSPDGLAAGRSEGALQVLDGEVGSLDGTPQT 300
Query: 301 REVAAEAVPETREAGAQAVPETREAGVEAAPETVEADAWVTEALLGLPAAAERELELLRA 360
REVAAEAVPETREAGAQAVPETREAGVEAAPETVEADAWVTEALLGLPAAAERELELLRA
Sbjct: 301 REVAAEAVPETREAGAQAVPETREAGVEAAPETVEADAWVTEALLGLPAAAERELELLRA 360
Query: 361 SLEHQRGVSELLRGRLRELEEAREAAEEAAAGARAQLREATTQTPWSCAEKAAQTESPAE 420
SLEHQRGVSELLRGRLRELEEAREAAEEAAAGARAQLREATTQTPWSCAEKAAQTESPAE
Sbjct: 361 SLEHQRGVSELLRGRLRELEEAREAAEEAAAGARAQLREATTQTPWSCAEKAAQTESPAE 420
Query: 421 APSLTQESSPGSMDGDRAVAPAGILKSIMKKRDGTPGAQPSSGPKSLQFVGVLNGEYESS 480
APSLTQESSPGSMDGDRAVAPAGILKSIMKKRDGTPGAQPSSGPKSLQFVGVLNGEYESS
Sbjct: 421 APSLTQESSPGSMDGDRAVAPAGILKSIMKKRDGTPGAQPSSGPKSLQFVGVLNGEYESS 480
Query: 481 SSEDASDSDGDSENGGAEPPGSSSGSGDDSGGGSDSGTPGPPSGGDIRDPEPEAEAEPQQ 540
SSEDASDSDGDSENGGAEPPGSSSGSGDDSGGGSDSGTPGPPSGGDIRDPEPEAEAEPQQ
Sbjct: 481 SSEDASDSDGDSENGGAEPPGSSSGSGDDSGGGSDSGTPGPPSGGDIRDPEPEAEAEPQQ 540
Query: 541 VAQGRCELSPRLREACVALQRQLSRPRGVASDGGAVRLVAQEWFRVSSQRRSQAEPVARM 600
VAQGRCELSPRLREACVALQRQLSRPRGVASDGGAVRLVAQEWFRVSSQRRSQAEPVARM
Sbjct: 541 VAQGRCELSPRLREACVALQRQLSRPRGVASDGGAVRLVAQEWFRVSSQRRSQAEPVARM 600
Query: 601 LEGVRRLGPELLAHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSA 660
LEGVRRLGPELLAHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSA
Sbjct: 601 LEGVRRLGPELLAHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSA 660
Query: 661 LMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGA 720
LMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGA
Sbjct: 661 LMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGA 720
Query: 721 DVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAA 780
DVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAA
Sbjct: 721 DVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAA 780
Query: 781 LLHAHLSSGQPDTQSESPPGSQTATPGEGECGDNGENPQVQ 821
LLHAHLSSGQPDTQSESPPGSQTATPGEGECGDNGENPQVQ
Sbjct: 781 LLHAHLSSGQPDTQSESPPGSQTATPGEGECGDNGENPQVQ 821
>gi|209969812 ankyrin repeat domain 25 [Homo sapiens]
Length = 851
Score = 376 bits (966), Expect = e-104
Identities = 302/871 (34%), Positives = 424/871 (48%), Gaps = 134/871 (15%)
Query: 22 PAAGGARSPSSPYSVETPYGFHLDLDFLKYIEELERGPAARRAPGPPTSRRPRAPRPGLA 81
P A A+ P PYSVETPYG+ LDLDFLKY++++E+G RR RRPR +
Sbjct: 20 PPAFPAKDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVA---VQRRPRLS----S 72
Query: 82 GARSPGAW-TSSESLASDDGGAPGILSQGAPSGLLMQPLSPRAPVR---NPRVEHTLRET 137
R PG+W TS+ESL S+ G S + G P R NPRVE TL +
Sbjct: 73 LPRGPGSWWTSTESLCSNASG-DSRHSAYSYCGRGFYPQYGALETRGGFNPRVERTLLDA 131
Query: 138 SRRLELAQTHERAPSP------------------GRGVPR-SPRGSGRSSPAPNLAPASP 178
RRLE ++A +P G G+P +PR SG S+P P P
Sbjct: 132 RRRLE-----DQAATPTGLGSLTPSAAGSTASLVGVGLPPPTPRSSGLSTPVP------P 180
Query: 179 GPAQLQLVREQMAAALRRLRELEDQARTLPELQEQVRALRAEKARLL------------- 225
L VREQMA ALR+LR+LE+Q + +P LQ ++ L+ EK +L
Sbjct: 181 SAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPT 240
Query: 226 AGRAQPE-------------------------------PDGEAETRPDKLAQLRRLTERL 254
AGR + E PDGEA K+A L ++
Sbjct: 241 AGRGRSELCLDLPDPPEDPVALETRSVGTWVRERDLGMPDGEAALAA-KVAVLETQLKKA 299
Query: 255 ATSERGGRAR-------ASPRADSPDGLAAGRSEGALQVLDGEVGSLDGTPQTREVAAEA 307
+ +AR A P DSP + R + ++ + G P R + E
Sbjct: 300 LQELQAAQARQADPQPQAWPPPDSPVRVDTVRVVEGPREVEVVASTAAGAPAQRAQSLE- 358
Query: 308 VPETREAGAQAVPETREAGVEAAPETVEADAWVTEALLGLPAAAERELELLRASLEHQRG 367
P A A+P G +P + V E + +PAAA + +++ +R
Sbjct: 359 -PYGTGLRALAMP-----GRPESPPVFRSQE-VVETMCPVPAAATSNVHMVKKISITERS 411
Query: 368 VSELLRGRLRELEEAREAAEEAAAGARAQLREATTQTPWSCAEKAAQTESPAEAPSLTQE 427
G E E++ A L + T ++ E +A S E
Sbjct: 412 CD----GAAGLPEVPAESSSSPPGSEVASLTQPEKSTGRVPTQEPTHREPTRQAASQESE 467
Query: 428 SSPGSMDGDRAVAPAGILKSIMKKRDGTPGAQPSSGPKSLQFVGVLNGEYESSSSEDASD 487
+ G+ PAG+ +SIMK+++ A P++ +SLQFVGV NG YESSS ED+S
Sbjct: 468 EAGGT-----GGPPAGV-RSIMKRKEEV--ADPTAHRRSLQFVGV-NGGYESSS-EDSST 517
Query: 488 SDGDSENGGAEPPGSSSGSGDDSGGGSDSGTPGPPSGGDIRDPEPEAEAEPQQV--AQG- 544
++ S+N E S + P + E + E Q + A+G
Sbjct: 518 AENISDNDSTENEAPEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGA 577
Query: 545 ---------RCELSPRLREACVALQRQLSRPRGVASDG--GAVRLVAQEWFRVSSQRRSQ 593
R ELSP L AC+AL++ L P + A V QEW R++ + +
Sbjct: 578 SGSNTEEEIRMELSPDLISACLALEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAH 637
Query: 594 AEPVARMLEGVRRLGPELLAHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQ 653
E V R L R + LL +VVN+AD NGNTALHYSVSH N + LLD+G C+V++Q
Sbjct: 638 PELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQ 697
Query: 654 NRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVA 713
NRAGYS +ML AL +++ ++ D+ V +LF +G++NAKASQ GQTALMLA+SHGR D+V
Sbjct: 698 NRAGYSPIMLTALATLKTQD-DIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVK 756
Query: 714 TLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEA 773
LLAC ADVN QD DG+TALMCA E+G + LLL P CD ++ D +G++AL +AL+A
Sbjct: 757 ALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDA 816
Query: 774 EQDEVAALLHAHLS---SGQPDTQSESPPGS 801
Q E+A++L++ ++ S P + ESP S
Sbjct: 817 GQSEIASMLYSRMNIKCSFAPMSDDESPTSS 847
>gi|31324547 ankyrin repeat domain 25 [Homo sapiens]
Length = 851
Score = 376 bits (966), Expect = e-104
Identities = 302/871 (34%), Positives = 424/871 (48%), Gaps = 134/871 (15%)
Query: 22 PAAGGARSPSSPYSVETPYGFHLDLDFLKYIEELERGPAARRAPGPPTSRRPRAPRPGLA 81
P A A+ P PYSVETPYG+ LDLDFLKY++++E+G RR RRPR +
Sbjct: 20 PPAFPAKDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVA---VQRRPRLS----S 72
Query: 82 GARSPGAW-TSSESLASDDGGAPGILSQGAPSGLLMQPLSPRAPVR---NPRVEHTLRET 137
R PG+W TS+ESL S+ G S + G P R NPRVE TL +
Sbjct: 73 LPRGPGSWWTSTESLCSNASG-DSRHSAYSYCGRGFYPQYGALETRGGFNPRVERTLLDA 131
Query: 138 SRRLELAQTHERAPSP------------------GRGVPR-SPRGSGRSSPAPNLAPASP 178
RRLE ++A +P G G+P +PR SG S+P P P
Sbjct: 132 RRRLE-----DQAATPTGLGSLTPSAAGSTASLVGVGLPPPTPRSSGLSTPVP------P 180
Query: 179 GPAQLQLVREQMAAALRRLRELEDQARTLPELQEQVRALRAEKARLL------------- 225
L VREQMA ALR+LR+LE+Q + +P LQ ++ L+ EK +L
Sbjct: 181 SAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPT 240
Query: 226 AGRAQPE-------------------------------PDGEAETRPDKLAQLRRLTERL 254
AGR + E PDGEA K+A L ++
Sbjct: 241 AGRGRSELCLDLPDPPEDPVALETRSVGTWVRERDLGMPDGEAALAA-KVAVLETQLKKA 299
Query: 255 ATSERGGRAR-------ASPRADSPDGLAAGRSEGALQVLDGEVGSLDGTPQTREVAAEA 307
+ +AR A P DSP + R + ++ + G P R + E
Sbjct: 300 LQELQAAQARQADPQPQAWPPPDSPVRVDTVRVVEGPREVEVVASTAAGAPAQRAQSLE- 358
Query: 308 VPETREAGAQAVPETREAGVEAAPETVEADAWVTEALLGLPAAAERELELLRASLEHQRG 367
P A A+P G +P + V E + +PAAA + +++ +R
Sbjct: 359 -PYGTGLRALAMP-----GRPESPPVFRSQE-VVETMCPVPAAATSNVHMVKKISITERS 411
Query: 368 VSELLRGRLRELEEAREAAEEAAAGARAQLREATTQTPWSCAEKAAQTESPAEAPSLTQE 427
G E E++ A L + T ++ E +A S E
Sbjct: 412 CD----GAAGLPEVPAESSSSPPGSEVASLTQPEKSTGRVPTQEPTHREPTRQAASQESE 467
Query: 428 SSPGSMDGDRAVAPAGILKSIMKKRDGTPGAQPSSGPKSLQFVGVLNGEYESSSSEDASD 487
+ G+ PAG+ +SIMK+++ A P++ +SLQFVGV NG YESSS ED+S
Sbjct: 468 EAGGT-----GGPPAGV-RSIMKRKEEV--ADPTAHRRSLQFVGV-NGGYESSS-EDSST 517
Query: 488 SDGDSENGGAEPPGSSSGSGDDSGGGSDSGTPGPPSGGDIRDPEPEAEAEPQQV--AQG- 544
++ S+N E S + P + E + E Q + A+G
Sbjct: 518 AENISDNDSTENEAPEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGA 577
Query: 545 ---------RCELSPRLREACVALQRQLSRPRGVASDG--GAVRLVAQEWFRVSSQRRSQ 593
R ELSP L AC+AL++ L P + A V QEW R++ + +
Sbjct: 578 SGSNTEEEIRMELSPDLISACLALEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAH 637
Query: 594 AEPVARMLEGVRRLGPELLAHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQ 653
E V R L R + LL +VVN+AD NGNTALHYSVSH N + LLD+G C+V++Q
Sbjct: 638 PELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQ 697
Query: 654 NRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVA 713
NRAGYS +ML AL +++ ++ D+ V +LF +G++NAKASQ GQTALMLA+SHGR D+V
Sbjct: 698 NRAGYSPIMLTALATLKTQD-DIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVK 756
Query: 714 TLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEA 773
LLAC ADVN QD DG+TALMCA E+G + LLL P CD ++ D +G++AL +AL+A
Sbjct: 757 ALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDA 816
Query: 774 EQDEVAALLHAHLS---SGQPDTQSESPPGS 801
Q E+A++L++ ++ S P + ESP S
Sbjct: 817 GQSEIASMLYSRMNIKCSFAPMSDDESPTSS 847
>gi|23510377 KN motif and ankyrin repeat domains 1 isoform b [Homo
sapiens]
Length = 1194
Score = 292 bits (748), Expect = 8e-79
Identities = 171/375 (45%), Positives = 231/375 (61%), Gaps = 23/375 (6%)
Query: 445 LKSIMKKRDGTPGAQPSSGPKSLQFVGVLNGEYESSSSEDASDSDGDSENGGAE------ 498
LKSIMKK+DG + + K+LQFVG+ NG YE++SS+D+S + S E
Sbjct: 816 LKSIMKKKDGNKDS--NGAKKNLQFVGI-NGGYETTSSDDSSSDESSSSESDDECDVIEY 872
Query: 499 PPGSSSGSGDDSGGGSDSGTPGPPSGG----DIRDPEPEAEAEPQQVA-QGRCELSPRLR 553
P D+ G G G + D E EP++V + R ELS ++
Sbjct: 873 PLEEEEEEEDEDTRGMAEGHHAVNIEGLKSARVEDEMQVQECEPEKVEIRERYELSEKML 932
Query: 554 EACVALQRQLSRPRGVASDGG--AVRLVAQEWFRVSSQRRSQAEPVARMLEGVRRLGPEL 611
AC L+ ++ P+ + S + + EWFRVSSQ+ + V + + P++
Sbjct: 933 SACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISPDV 992
Query: 612 LAHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQ 671
L +V+NLADGNGNTALHYSVSH N I LLLD C V+ QN+AGY+ +MLAAL +V +
Sbjct: 993 LRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAV-E 1051
Query: 672 EEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGAT 731
E+DM +V+ LF GDVNAKASQ GQTALMLA+SHGR DMV LLACGADVN QD +G+T
Sbjct: 1052 AEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGST 1111
Query: 732 ALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHL----- 786
ALMCASE+G ++ V+LLL QPGC+ + DN+G++AL+IALEA ++A LL+AH+
Sbjct: 1112 ALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKA 1171
Query: 787 -SSGQPDTQSESPPG 800
S G P ++ PG
Sbjct: 1172 QSPGTPRLGRKTSPG 1186
Score = 79.0 bits (193), Expect = 2e-14
Identities = 78/283 (27%), Positives = 128/283 (45%), Gaps = 36/283 (12%)
Query: 152 SPGRGVPRSPRGSGRSSPAPNLAPASPGPAQLQLVREQMAAALRRLRELEDQARTLPELQ 211
S G + SP SG S+P N++P LQ +REQMA AL+RL+ELE+Q RT+P LQ
Sbjct: 76 SMGSSIRHSPLSSGISTPVTNVSPM-----HLQHIREQMAIALKRLKELEEQVRTIPVLQ 130
Query: 212 EQVRALRAEKARLLA----GRAQPEPDGEAETRPDKLAQLRRLTERLATSER-GGRARAS 266
++ L+ EK +L++ RA + + + A E+L+ + R GG
Sbjct: 131 VKISVLQEEKRQLVSQLKNQRAASQINVCGVRKRSYSAGNASQLEQLSRARRSGGELYID 190
Query: 267 PRADSPDGLAAGRSE-GALQVLDGEVGSLDGTPQTREVAAEAVPETREAGA--------- 316
+ + + + L ++ +L+ + ++ + EA E RE G
Sbjct: 191 YEEEEMETVEQSTQRIKEFRQLTADMQALE--QKIQDSSCEASSELRENGECRSVAVGAE 248
Query: 317 ----------QAVPETREAGVEAAPETVEADAWVTEALLGLPAAAERELELLRASLEHQR 366
+ ++A V E VTEA+LG+ A++E+EL + ++E +
Sbjct: 249 ENMNDIVVYHRGSRSCKDAAVGTLVEMRNCGVSVTEAMLGVMTEADKEIELQQQTIESLK 308
Query: 367 GVSELLRGRLRELEEAREAA----EEAAAGARAQLREATTQTP 405
L +LRE RE E AAG+R ++ +AT P
Sbjct: 309 EKIYRLEVQLRETTHDREMTKLKQELQAAGSRKKVDKATMAQP 351
>gi|64464726 KN motif and ankyrin repeat domains 1 isoform a [Homo
sapiens]
Length = 1352
Score = 292 bits (748), Expect = 8e-79
Identities = 171/375 (45%), Positives = 231/375 (61%), Gaps = 23/375 (6%)
Query: 445 LKSIMKKRDGTPGAQPSSGPKSLQFVGVLNGEYESSSSEDASDSDGDSENGGAE------ 498
LKSIMKK+DG + + K+LQFVG+ NG YE++SS+D+S + S E
Sbjct: 974 LKSIMKKKDGNKDS--NGAKKNLQFVGI-NGGYETTSSDDSSSDESSSSESDDECDVIEY 1030
Query: 499 PPGSSSGSGDDSGGGSDSGTPGPPSGG----DIRDPEPEAEAEPQQVA-QGRCELSPRLR 553
P D+ G G G + D E EP++V + R ELS ++
Sbjct: 1031 PLEEEEEEEDEDTRGMAEGHHAVNIEGLKSARVEDEMQVQECEPEKVEIRERYELSEKML 1090
Query: 554 EACVALQRQLSRPRGVASDGG--AVRLVAQEWFRVSSQRRSQAEPVARMLEGVRRLGPEL 611
AC L+ ++ P+ + S + + EWFRVSSQ+ + V + + P++
Sbjct: 1091 SACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISPDV 1150
Query: 612 LAHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQ 671
L +V+NLADGNGNTALHYSVSH N I LLLD C V+ QN+AGY+ +MLAAL +V +
Sbjct: 1151 LRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAV-E 1209
Query: 672 EEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGAT 731
E+DM +V+ LF GDVNAKASQ GQTALMLA+SHGR DMV LLACGADVN QD +G+T
Sbjct: 1210 AEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGST 1269
Query: 732 ALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHL----- 786
ALMCASE+G ++ V+LLL QPGC+ + DN+G++AL+IALEA ++A LL+AH+
Sbjct: 1270 ALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKA 1329
Query: 787 -SSGQPDTQSESPPG 800
S G P ++ PG
Sbjct: 1330 QSPGTPRLGRKTSPG 1344
Score = 117 bits (294), Expect = 3e-26
Identities = 132/492 (26%), Positives = 200/492 (40%), Gaps = 121/492 (24%)
Query: 28 RSPSSPYSVETPYGFHLDLDFLKYIEELERGPAARRAPGPPTSRRPRAPRP-GLAGARSP 86
+ PY VETPYG+ LDLDFLKY++++++G +R R+P P P +
Sbjct: 25 KEQKDPYFVETPYGYQLDLDFLKYVDDIQKGNTIKRL-NIQKRRKPSVPCPEPRTTSGQQ 83
Query: 87 GAWTSSESLAS----DDGGAPGILSQGA-----------------------PSGLLMQPL 119
G WTS+ESL+S D+ P L + P + P
Sbjct: 84 GIWTSTESLSSSNSDDNKQCPNFLIARSQVTSTPISKPPPPLETSLPFLTIPENRQLPPP 143
Query: 120 SPRAPVRNPRVEHTLRETSRRLELAQ-THERAPSPGRGVPRSPR---------------- 162
SP+ P N V TL ET RRLE + T + P G R PR
Sbjct: 144 SPQLPKHNLHVTKTLMETRRRLEQERATMQMTP----GEFRRPRLASFGGMGTTSSLPSF 199
Query: 163 -GSGRSSPAP--------------NLAPASP-------------------------GPAQ 182
GSG +PA + APA+P P
Sbjct: 200 VGSGNHNPAKHQLQNGYQGNGDYGSYAPAAPTTSSMGSSIRHSPLSSGISTPVTNVSPMH 259
Query: 183 LQLVREQMAAALRRLRELEDQARTLPELQEQVRALRAEKARLLA----GRAQPEPDGEAE 238
LQ +REQMA AL+RL+ELE+Q RT+P LQ ++ L+ EK +L++ RA + +
Sbjct: 260 LQHIREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQLVSQLKNQRAASQINVCGV 319
Query: 239 TRPDKLAQLRRLTERLATSER-GGRARASPRADSPDGLAAGRSE-GALQVLDGEVGSLDG 296
+ A E+L+ + R GG + + + + L ++ +L+
Sbjct: 320 RKRSYSAGNASQLEQLSRARRSGGELYIDYEEEEMETVEQSTQRIKEFRQLTADMQALE- 378
Query: 297 TPQTREVAAEAVPETREAGA-------------------QAVPETREAGVEAAPETVEAD 337
+ ++ + EA E RE G + ++A V E
Sbjct: 379 -QKIQDSSCEASSELRENGECRSVAVGAEENMNDIVVYHRGSRSCKDAAVGTLVEMRNCG 437
Query: 338 AWVTEALLGLPAAAERELELLRASLEHQRGVSELLRGRLRELEEAREAA----EEAAAGA 393
VTEA+LG+ A++E+EL + ++E + L +LRE RE E AAG+
Sbjct: 438 VSVTEAMLGVMTEADKEIELQQQTIESLKEKIYRLEVQLRETTHDREMTKLKQELQAAGS 497
Query: 394 RAQLREATTQTP 405
R ++ +AT P
Sbjct: 498 RKKVDKATMAQP 509
>gi|156104862 ankyrin repeat domain 38 [Homo sapiens]
Length = 995
Score = 258 bits (660), Expect = 1e-68
Identities = 228/714 (31%), Positives = 321/714 (44%), Gaps = 64/714 (8%)
Query: 114 LLMQPLSPRAPVRNPRVEHTLRETSRRLELAQTHERAPSPGRGVPRSPRG--SGRSSPAP 171
L + + P PV +R T L LA+ + S + + G SGR+
Sbjct: 305 LNISEIPPPPPVEVDMRSIGIRVTEESLGLARVDPGSISSLKQQVSALEGELSGRTEELA 364
Query: 172 NLAPASPGPAQLQLVREQMAAALRRLRELEDQARTLPELQEQVRALRAEKARLLAGRAQP 231
+ A LQ E++ A +R+RELE L Q A + + P
Sbjct: 365 QVRTA------LQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQTDVMVNTDP 418
Query: 232 EPDGEAETRPDKLAQLRRLTERLATSERGGRARASPRADSPDGLAAGRSEGALQVLDGEV 291
DK ++ L + + G R + PDG G A +VL ++
Sbjct: 419 VHGLLTRESCDKGIEVNLLGS-MESESWGHRGEENGLLWGPDGHKQGNQSPAERVLLPQL 477
Query: 292 GSLDGTPQTREVAAEAVPETREAGAQAVPETREAGVEAAPETVEADAWVTEALLGLPAAA 351
G Q + + T +A E +E G + W ++ P A
Sbjct: 478 SLPQGPEQVLTSSVHSFLSTELRIEEAGTE-QEGGPQGGTRGAGGFLWGSDRKT--PPAG 534
Query: 352 ERELELLRASLEHQ----------------RGVSELLRGRLRELEEAREAAEEAAAGARA 395
E EH + + ELL+ + LE A +
Sbjct: 535 REETSSNLPGKEHPGRPPSSPTDATIGQYVKKIQELLQEQWNCLEHGYPELASAIKQPAS 594
Query: 396 QLREATTQTPWSC----AEKAAQTESPAEAPSLTQESSPGSMDGDRAVAPAGILKSIMKK 451
+L +Q S + +AQ P E P+ SSP ++P+ LKSIMKK
Sbjct: 595 KLSSIQSQLLSSLNLLLSAYSAQAHPPKEPPA--SSSSPPV-----EISPSTSLKSIMKK 647
Query: 452 RDGTPGAQPSSGPKSLQFVGVLNGEYESSSSEDASDSDGDSENGGAEPPGSSSGSGD--- 508
+D A + K+LQFVGV NG YE++SSE+ S D E+ D
Sbjct: 648 KDYGFRAGGNGTKKNLQFVGV-NGGYETTSSEETSGEDSTPEDLSDSEAEKKCDGPDHKH 706
Query: 509 --------DSGGGSDSGTPGPPSGGDIRDPEPEAEAEPQQVAQGRCELSPRLREACVALQ 560
++G G GT + P ++AE R + S AC AL
Sbjct: 707 VKDAHLTCEAGQGIPEGTCHAAQESGPGEEVPHSKAE-------RYKPSEEFLNACRALS 759
Query: 561 RQLSRPRGVASDG---GAVRLVAQEWFRVSSQRRSQAEPVARMLEGVRRLGPELLAHVVN 617
+ L G +D ++ ++QEWFRVSS++ S VA L V+ P L +VN
Sbjct: 760 QHLPET-GTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVN 818
Query: 618 LADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMA 677
LAD NGNTALHYSVSH N +I LLL+TG C V+ QN+AGY+A+M+ L S + EDMA
Sbjct: 819 LADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASA-ETNEDMA 877
Query: 678 VVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCAS 737
VV +L G+VN +A+Q GQTALML +SH R+DMV LL+C ADVN QD DG++ALM A
Sbjct: 878 VVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVAC 937
Query: 738 EYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQD-EVAALLHAHLSSGQ 790
+G +D VRLLL P CD ++ D G +AL+IAL++ E+A LL AH G+
Sbjct: 938 HHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGR 991
Score = 75.1 bits (183), Expect = 2e-13
Identities = 62/176 (35%), Positives = 83/176 (47%), Gaps = 30/176 (17%)
Query: 31 SSPYSVETPYGFHLDLDFLKYIEELERG------PAARRAPGPPTSRRPRAPRPGLAGAR 84
S PYSVETPYGFHLDLDFLKY++++E+G P RRA S PR +GAR
Sbjct: 22 SHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRNFSLPDSGAR 81
Query: 85 SPGA-----WT----SSESLASDDGGAPGILSQGAPSGLLMQPLSPRAPVRNPRVEHTLR 135
P A W+ SL + + +Q P G Q + R+ V R + L
Sbjct: 82 PPAAPPLQNWSPVVPREASLGTQE------QNQSPPLGNAPQASTSRSEVSYHR-KALLA 134
Query: 136 ETSRRLELAQTHERAPSPGRGVPRSPRGS--------GRSSPAPNLAPASPGPAQL 183
E +R+LE A+ + + G G P+ R S R+S P L+ P P L
Sbjct: 135 EATRQLEAAEPEDAELTFGSGRPQLLRASSMPATLLHSRASEEPGLSLGPPAPPAL 190
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 72.8 bits (177), Expect = 1e-12
Identities = 58/167 (34%), Positives = 86/167 (51%), Gaps = 8/167 (4%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
V+ D +G T L + G++ L+ GA ++N Q +G +AL AA +Q D
Sbjct: 39 VDCRDSHGTTLLMVAAYAGHIDCVRELVLQGA-DINLQRESGTTALFFAA----QQGHND 93
Query: 676 MAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMC 735
VV+ LF G ++ G TAL+ A +G +V TLL GA+++ Q DGATAL
Sbjct: 94 --VVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFL 151
Query: 736 ASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALL 782
A++ G LD +RLLL G +GT+ L IA + EV ++
Sbjct: 152 AAQGGYLDVIRLLLAS-GAKVNQPRQDGTAPLWIASQMGHSEVVRVM 197
Score = 64.7 bits (156), Expect = 3e-10
Identities = 53/163 (32%), Positives = 75/163 (46%), Gaps = 8/163 (4%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
+NL +G TAL ++ G+ + L GA R G +AL+ A+ +
Sbjct: 72 INLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGG-TALLAAS------QYGH 124
Query: 676 MAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMC 735
M VV+ L G G TAL LA G D++ LLA GA VN DG L
Sbjct: 125 MQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWI 184
Query: 736 ASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEV 778
AS+ G + VR++L + G D N+GT+AL A ++V
Sbjct: 185 ASQMGHSEVVRVMLLR-GADRDAARNDGTTALLKAANKGYNDV 226
Score = 56.2 bits (134), Expect = 1e-07
Identities = 57/178 (32%), Positives = 82/178 (46%), Gaps = 10/178 (5%)
Query: 622 NGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQR 681
+G TAL + +G++ + LL GA ++ Q G +AL LAA + V++
Sbjct: 111 DGGTALLAASQYGHMQVVETLLKHGA-NIHDQLYDGATALFLAAQGGY------LDVIRL 163
Query: 682 LFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGR 741
L G + Q G L +A G ++V +L GAD +A DG TAL+ A+ G
Sbjct: 164 LLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGY 223
Query: 742 LDTVRLLLTQPGCDPAILDNEGTSAL-AIALEAEQDEVAALLHAHLSSGQPDTQSESP 798
D ++ LL + IL N GTSAL A L VA LL A + +E P
Sbjct: 224 NDVIKELL-KFSPTLGILKN-GTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELP 279
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 69.3 bits (168), Expect = 1e-11
Identities = 63/190 (33%), Positives = 93/190 (48%), Gaps = 9/190 (4%)
Query: 620 DGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVV 679
D + TALH++ S G+ I LL G VN ++ AG+S L +AA S ++E +V
Sbjct: 37 DQDSRTALHWACSAGHTEIVEFLLQLGV-PVNDKDDAGWSPLHIAA--SAGRDE----IV 89
Query: 680 QRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEY 739
+ L G +Q G T L A S R ++ LL GA+ +A+D ATA+ A+
Sbjct: 90 KALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
Query: 740 GRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDTQSESPP 799
G L + +LL I D EG + L +A + E+ E A LL + +S + + E P
Sbjct: 150 GNLKMIHILLYYK-ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTP 208
Query: 800 GSQTATPGEG 809
Q A G G
Sbjct: 209 -LQVAKGGLG 217
Score = 49.7 bits (117), Expect = 1e-05
Identities = 49/156 (31%), Positives = 72/156 (46%), Gaps = 10/156 (6%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
VN D G + LH + S G I LL GA +VN N+ G + L AA + +
Sbjct: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGA-QVNAVNQNGCTPLHYAA----SKNRHE 120
Query: 676 MAVVQRLFCMGDVNAKASQTGQ-TALMLAISHGRQDMVATLLACGADVNAQDADGATALM 734
+AV + G N A + TA+ A + G M+ LL A N QD +G T L
Sbjct: 121 IAV---MLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLH 177
Query: 735 CASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIA 770
A + R++ +LL++Q G I + E + L +A
Sbjct: 178 LACDEERVEEAKLLVSQ-GASIYIENKEEKTPLQVA 212
Score = 33.1 bits (74), Expect = 1.1
Identities = 34/124 (27%), Positives = 49/124 (39%), Gaps = 5/124 (4%)
Query: 702 LAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDN 761
LA S +++ ++LA + D D TAL A G + V LL Q G D+
Sbjct: 13 LAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL-QLGVPVNDKDD 71
Query: 762 EGTSALAIALEAEQDEVAALLHAHLSSGQPDTQSESPPGSQTATPGEGECG----DNGEN 817
G S L IA A +DE+ L + Q+ P A+ E + G N
Sbjct: 72 AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
Query: 818 PQVQ 821
P +
Sbjct: 132 PDAK 135
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 69.3 bits (168), Expect = 1e-11
Identities = 67/210 (31%), Positives = 99/210 (47%), Gaps = 16/210 (7%)
Query: 597 VARMLEGVRRLGPELLAH--VVNLADGNGNTALHYSV-----SHGNLAIASLLLDTGACE 649
+A G R + LL H VN D +G TAL + S G+ ++ SLL+D GA E
Sbjct: 682 IAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGA-E 740
Query: 650 VNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQ 709
V+ ++ G + L++AA E + VV L G G+T L+ A S G
Sbjct: 741 VDHCDKDGMTPLLVAAY------EGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHA 794
Query: 710 DMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAI 769
+V TLL GA V++ D++G T L AS G ++ VR LL + G D D+ G + L +
Sbjct: 795 SVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDR-GLDENHRDDAGWTPLHM 853
Query: 770 -ALEAEQDEVAALLHAHLSSGQPDTQSESP 798
A E + AL+ + + D P
Sbjct: 854 AAFEGHRLICEALIEQGARTNEIDNDGRIP 883
Score = 67.8 bits (164), Expect = 4e-11
Identities = 57/170 (33%), Positives = 81/170 (47%), Gaps = 8/170 (4%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
VN D NG T L + G+L + +LL+ GA ++ ++ G++ L LAA ++
Sbjct: 538 VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGA-DLEIEDAHGHTPLTLAA-----RQGHT 591
Query: 676 MAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMC 735
V + C ++N Q G TAL A G ++V+ LL G V+ DAD TAL
Sbjct: 592 KVVNCLIGCGANIN-HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650
Query: 736 ASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAH 785
A+ G D V L L Q G + DNEG +AL A E+ L H
Sbjct: 651 AAWGGHEDIV-LNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDH 699
Score = 63.9 bits (154), Expect = 6e-10
Identities = 53/168 (31%), Positives = 81/168 (48%), Gaps = 16/168 (9%)
Query: 622 NGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQR 681
+G AL + G+ I LL GA +VN ++ G L + AL E+ +
Sbjct: 912 DGRNALRVAALEGHRDIVELLFSHGA-DVNCKDADGRPTLYILAL-------ENQLTMAE 963
Query: 682 LFCMGDVNAKASQT-GQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYG 740
F N +AS G+TAL ++ G +MV L+A ADVNA D + +AL A+ G
Sbjct: 964 YFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQG 1023
Query: 741 RLDTVRLLLTQPGCDPAILD---NEGTSALAIALEAEQDEVAALLHAH 785
+ V+LL+ A++D N+G +AL IA + +V +L H
Sbjct: 1024 HVKVVQLLIEH----GAVVDHTCNQGATALCIAAQEGHIDVVQVLLEH 1067
Score = 60.5 bits (145), Expect = 6e-09
Identities = 49/147 (33%), Positives = 68/147 (46%), Gaps = 12/147 (8%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
V +D G TALH S G++ + +L+ A +VN + SAL AA +
Sbjct: 972 VEASDAEGRTALHVSCWQGHMEMVQVLIAYHA-DVNAADNEKRSALQSAAW------QGH 1024
Query: 676 MAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMC 735
+ VVQ L G V G TAL +A G D+V LL GAD N D G TA+
Sbjct: 1025 VKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRV 1084
Query: 736 ASEYGRLDTVRLL-----LTQPGCDPA 757
A++ G ++LL + GC P+
Sbjct: 1085 AAKNGHSQIIKLLEKYGASSLNGCSPS 1111
Score = 58.9 bits (141), Expect = 2e-08
Identities = 60/189 (31%), Positives = 83/189 (43%), Gaps = 14/189 (7%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
+N D +G TAL + G+ + S LL G +V+ + +AL AA ED
Sbjct: 604 INHTDQDGWTALRSAAWGGHTEVVSALLYAGV-KVDCADADSRTALRAAAWGG----HED 658
Query: 676 MAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMC 735
+V L G KA G+TAL+ A G +++V LL GA+VN +D DG TAL
Sbjct: 659 --IVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSV 716
Query: 736 A-----SEYGRLDTVRLLLTQPGCDPAILDNEG-TSALAIALEAEQDEVAALLHAHLSSG 789
A + G V LL+ + G + D +G T L A E D V LL
Sbjct: 717 AALCVPASKGHASVVSLLIDR-GAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD 775
Query: 790 QPDTQSESP 798
D +P
Sbjct: 776 HTDNNGRTP 784
Score = 48.1 bits (113), Expect = 3e-05
Identities = 45/144 (31%), Positives = 61/144 (42%), Gaps = 8/144 (5%)
Query: 642 LLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALM 701
LLD GA VN+ + G + L AA + + VV L G G T L
Sbjct: 531 LLDNGA-SVNQCDSNGRTLLANAAYSG------SLDVVNLLVSRGADLEIEDAHGHTPLT 583
Query: 702 LAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDN 761
LA G +V L+ CGA++N D DG TAL A+ G + V LL G D
Sbjct: 584 LAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALL-YAGVKVDCADA 642
Query: 762 EGTSALAIALEAEQDEVAALLHAH 785
+ +AL A +++ L H
Sbjct: 643 DSRTALRAAAWGGHEDIVLNLLQH 666
Score = 45.8 bits (107), Expect = 2e-04
Identities = 41/132 (31%), Positives = 60/132 (45%), Gaps = 6/132 (4%)
Query: 669 VRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDAD 728
VRQ E ++ L G + G+T L A G D+V L++ GAD+ +DA
Sbjct: 518 VRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAH 577
Query: 729 GATALMCASEYGRLDTVRLLLTQPGCDPAI--LDNEGTSAL-AIALEAEQDEVAALLHAH 785
G T L A+ G V L+ GC I D +G +AL + A + V+ALL+A
Sbjct: 578 GHTPLTLAARQGHTKVVNCLI---GCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAG 634
Query: 786 LSSGQPDTQSES 797
+ D S +
Sbjct: 635 VKVDCADADSRT 646
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/90 (34%), Positives = 48/90 (53%), Gaps = 1/90 (1%)
Query: 693 SQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQP 752
S+ +T+ ++ + R+D + TLL GA VN D++G T L A+ G LD V LL+++
Sbjct: 509 SEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSR- 567
Query: 753 GCDPAILDNEGTSALAIALEAEQDEVAALL 782
G D I D G + L +A +V L
Sbjct: 568 GADLEIEDAHGHTPLTLAARQGHTKVVNCL 597
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 68.6 bits (166), Expect = 2e-11
Identities = 45/145 (31%), Positives = 79/145 (54%), Gaps = 7/145 (4%)
Query: 646 GACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAIS 705
G ++N N+ G +AL LAA +E + +VQ L G A++ G TAL +A
Sbjct: 32 GGIDINTCNQNGLNALHLAA------KEGHVGLVQELLGRGSSVDSATKKGNTALHIASL 85
Query: 706 HGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTS 765
G+ ++V L+ GA++NAQ +G T L A++ +D V+ LL + G + + +G +
Sbjct: 86 AGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL-ENGANQSTATEDGFT 144
Query: 766 ALAIALEAEQDEVAALLHAHLSSGQ 790
LA+AL+ ++ A+L + + G+
Sbjct: 145 PLAVALQQGHNQAVAILLENDTKGK 169
Score = 67.0 bits (162), Expect = 7e-11
Identities = 51/154 (33%), Positives = 78/154 (50%), Gaps = 8/154 (5%)
Query: 617 NLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDM 676
N+ G T LH + G+ + +LLLD GA ++ ++G ++L LAA +E+ +
Sbjct: 635 NIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-NIHMSTKSGLTSLHLAA------QEDKV 687
Query: 677 AVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCA 736
V L G ++ G T L++A +G MV LL GA+VNA+ +G T L A
Sbjct: 688 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 747
Query: 737 SEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIA 770
++ G + +LL Q G P G +ALAIA
Sbjct: 748 AQQGHTHIINVLL-QHGAKPNATTANGNTALAIA 780
Score = 60.8 bits (146), Expect = 5e-09
Identities = 65/240 (27%), Positives = 100/240 (41%), Gaps = 32/240 (13%)
Query: 576 VRLVAQEWFRVSSQRRSQAEP--VARMLEGVRRLGPELLAHVVN--LADGNGNTALHYSV 631
VR + + V ++ R + P +A L G + LL H+ + A NG T LH S
Sbjct: 459 VRCLLRNGALVDARAREEQTPLHIASRL-GKTEIVQLLLQHMAHPDAATTNGYTPLHISA 517
Query: 632 SHGNLAIASLLLDTGACEVNRQNR--------AGYSALMLAALTSVRQEEEDMA------ 677
G + +AS+LL+ GA + A Y +L +A L R+ D A
Sbjct: 518 REGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLT 577
Query: 678 ------------VVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQ 725
V L G ++ G T L +A + + +TLL GA+ N
Sbjct: 578 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIV 637
Query: 726 DADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAH 785
G T L AS+ G D V LLL + G + + G ++L +A + ++ VA +L H
Sbjct: 638 TKQGVTPLHLASQEGHTDMVTLLLDK-GANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 696
Score = 52.0 bits (123), Expect = 2e-06
Identities = 46/160 (28%), Positives = 72/160 (45%), Gaps = 8/160 (5%)
Query: 623 GNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRL 682
G TALH + G + + LL GA V+ + R + L +A+ + +VQ L
Sbjct: 443 GETALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTE------IVQLL 495
Query: 683 FCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRL 742
A+ G T L ++ G+ D+ + LL GA + G T L A++YG L
Sbjct: 496 LQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL 555
Query: 743 DTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALL 782
D +LLL + + N G + L +A + +VA LL
Sbjct: 556 DVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLL 594
Score = 48.9 bits (115), Expect = 2e-05
Identities = 47/167 (28%), Positives = 68/167 (40%), Gaps = 14/167 (8%)
Query: 626 ALHYSVSHGNLAIASLLLDT-------GACEVNRQNRAGYSALMLAALTSVRQEEEDMAV 678
ALH + + A+LLL VNR +G++ L +AA ++ V
Sbjct: 174 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA------HYGNVNV 227
Query: 679 VQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASE 738
L G ++ G T L +A G +MV LL G ++A+ DG T L CA+
Sbjct: 228 ATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 287
Query: 739 YGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAH 785
G V LLL + G G S L +A + + E L H
Sbjct: 288 SGHDQVVELLL-ERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333
Score = 48.1 bits (113), Expect = 3e-05
Identities = 39/117 (33%), Positives = 58/117 (49%), Gaps = 9/117 (7%)
Query: 602 EGVRRLGPELLAH--VVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYS 659
EG L ELL V+ A GNTALH + G + +L+ GA +N Q++ G++
Sbjct: 53 EGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGA-NINAQSQNGFT 111
Query: 660 ALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLL 716
L +AA +E + VV+ L G + A++ G T L +A+ G VA LL
Sbjct: 112 PLYMAA------QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 162
Score = 48.1 bits (113), Expect = 3e-05
Identities = 39/134 (29%), Positives = 65/134 (48%), Gaps = 9/134 (6%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
++++ +G T+LH + + +A +L GA + + + GY+ L++A +
Sbjct: 667 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGA-DQDAHTKLGYTPLIVAC------HYGN 719
Query: 676 MAVVQRLFCMG-DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALM 734
+ +V L G +VNAK ++ G T L A G ++ LL GA NA A+G TAL
Sbjct: 720 VKMVNFLLKQGANVNAK-TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALA 778
Query: 735 CASEYGRLDTVRLL 748
A G + V L
Sbjct: 779 IAKRLGYISVVDTL 792
Score = 33.9 bits (76), Expect = 0.63
Identities = 48/193 (24%), Positives = 73/193 (37%), Gaps = 39/193 (20%)
Query: 622 NGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQR 681
+G T LH + G+ + LLL+ GA + R + G S L +AA + + + V+
Sbjct: 277 DGLTPLHCAARSGHDQVVELLLERGAPLLAR-TKNGLSPLHMAA------QGDHVECVKH 329
Query: 682 LFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGR 741
L + TAL +A G + LL A+ NA+ +G T L A + R
Sbjct: 330 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 389
Query: 742 LDTVR--------------------------------LLLTQPGCDPAILDNEGTSALAI 769
+ + LLL Q G P + + G +AL +
Sbjct: 390 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 449
Query: 770 ALEAEQDEVAALL 782
A A Q EV L
Sbjct: 450 AARAGQVEVVRCL 462
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 68.6 bits (166), Expect = 2e-11
Identities = 45/145 (31%), Positives = 79/145 (54%), Gaps = 7/145 (4%)
Query: 646 GACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAIS 705
G ++N N+ G +AL LAA +E + +VQ L G A++ G TAL +A
Sbjct: 53 GGIDINTCNQNGLNALHLAA------KEGHVGLVQELLGRGSSVDSATKKGNTALHIASL 106
Query: 706 HGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTS 765
G+ ++V L+ GA++NAQ +G T L A++ +D V+ LL + G + + +G +
Sbjct: 107 AGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL-ENGANQSTATEDGFT 165
Query: 766 ALAIALEAEQDEVAALLHAHLSSGQ 790
LA+AL+ ++ A+L + + G+
Sbjct: 166 PLAVALQQGHNQAVAILLENDTKGK 190
Score = 67.0 bits (162), Expect = 7e-11
Identities = 51/154 (33%), Positives = 78/154 (50%), Gaps = 8/154 (5%)
Query: 617 NLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDM 676
N+ G T LH + G+ + +LLLD GA ++ ++G ++L LAA +E+ +
Sbjct: 656 NIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-NIHMSTKSGLTSLHLAA------QEDKV 708
Query: 677 AVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCA 736
V L G ++ G T L++A +G MV LL GA+VNA+ +G T L A
Sbjct: 709 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768
Query: 737 SEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIA 770
++ G + +LL Q G P G +ALAIA
Sbjct: 769 AQQGHTHIINVLL-QHGAKPNATTANGNTALAIA 801
Score = 60.8 bits (146), Expect = 5e-09
Identities = 65/240 (27%), Positives = 100/240 (41%), Gaps = 32/240 (13%)
Query: 576 VRLVAQEWFRVSSQRRSQAEP--VARMLEGVRRLGPELLAHVVN--LADGNGNTALHYSV 631
VR + + V ++ R + P +A L G + LL H+ + A NG T LH S
Sbjct: 480 VRCLLRNGALVDARAREEQTPLHIASRL-GKTEIVQLLLQHMAHPDAATTNGYTPLHISA 538
Query: 632 SHGNLAIASLLLDTGACEVNRQNR--------AGYSALMLAALTSVRQEEEDMA------ 677
G + +AS+LL+ GA + A Y +L +A L R+ D A
Sbjct: 539 REGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLT 598
Query: 678 ------------VVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQ 725
V L G ++ G T L +A + + +TLL GA+ N
Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIV 658
Query: 726 DADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAH 785
G T L AS+ G D V LLL + G + + G ++L +A + ++ VA +L H
Sbjct: 659 TKQGVTPLHLASQEGHTDMVTLLLDK-GANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717
Score = 52.0 bits (123), Expect = 2e-06
Identities = 46/160 (28%), Positives = 72/160 (45%), Gaps = 8/160 (5%)
Query: 623 GNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRL 682
G TALH + G + + LL GA V+ + R + L +A+ + +VQ L
Sbjct: 464 GETALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTE------IVQLL 516
Query: 683 FCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRL 742
A+ G T L ++ G+ D+ + LL GA + G T L A++YG L
Sbjct: 517 LQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL 576
Query: 743 DTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALL 782
D +LLL + + N G + L +A + +VA LL
Sbjct: 577 DVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLL 615
Score = 48.9 bits (115), Expect = 2e-05
Identities = 47/167 (28%), Positives = 68/167 (40%), Gaps = 14/167 (8%)
Query: 626 ALHYSVSHGNLAIASLLLDT-------GACEVNRQNRAGYSALMLAALTSVRQEEEDMAV 678
ALH + + A+LLL VNR +G++ L +AA ++ V
Sbjct: 195 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA------HYGNVNV 248
Query: 679 VQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASE 738
L G ++ G T L +A G +MV LL G ++A+ DG T L CA+
Sbjct: 249 ATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 308
Query: 739 YGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAH 785
G V LLL + G G S L +A + + E L H
Sbjct: 309 SGHDQVVELLL-ERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Score = 48.1 bits (113), Expect = 3e-05
Identities = 39/117 (33%), Positives = 58/117 (49%), Gaps = 9/117 (7%)
Query: 602 EGVRRLGPELLAH--VVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYS 659
EG L ELL V+ A GNTALH + G + +L+ GA +N Q++ G++
Sbjct: 74 EGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGA-NINAQSQNGFT 132
Query: 660 ALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLL 716
L +AA +E + VV+ L G + A++ G T L +A+ G VA LL
Sbjct: 133 PLYMAA------QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Score = 48.1 bits (113), Expect = 3e-05
Identities = 39/134 (29%), Positives = 65/134 (48%), Gaps = 9/134 (6%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
++++ +G T+LH + + +A +L GA + + + GY+ L++A +
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGA-DQDAHTKLGYTPLIVAC------HYGN 740
Query: 676 MAVVQRLFCMG-DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALM 734
+ +V L G +VNAK ++ G T L A G ++ LL GA NA A+G TAL
Sbjct: 741 VKMVNFLLKQGANVNAK-TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALA 799
Query: 735 CASEYGRLDTVRLL 748
A G + V L
Sbjct: 800 IAKRLGYISVVDTL 813
Score = 33.9 bits (76), Expect = 0.63
Identities = 48/193 (24%), Positives = 73/193 (37%), Gaps = 39/193 (20%)
Query: 622 NGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQR 681
+G T LH + G+ + LLL+ GA + R + G S L +AA + + + V+
Sbjct: 298 DGLTPLHCAARSGHDQVVELLLERGAPLLAR-TKNGLSPLHMAA------QGDHVECVKH 350
Query: 682 LFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGR 741
L + TAL +A G + LL A+ NA+ +G T L A + R
Sbjct: 351 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 410
Query: 742 LDTVR--------------------------------LLLTQPGCDPAILDNEGTSALAI 769
+ + LLL Q G P + + G +AL +
Sbjct: 411 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 470
Query: 770 ALEAEQDEVAALL 782
A A Q EV L
Sbjct: 471 AARAGQVEVVRCL 483
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 68.6 bits (166), Expect = 2e-11
Identities = 45/145 (31%), Positives = 79/145 (54%), Gaps = 7/145 (4%)
Query: 646 GACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAIS 705
G ++N N+ G +AL LAA +E + +VQ L G A++ G TAL +A
Sbjct: 53 GGIDINTCNQNGLNALHLAA------KEGHVGLVQELLGRGSSVDSATKKGNTALHIASL 106
Query: 706 HGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTS 765
G+ ++V L+ GA++NAQ +G T L A++ +D V+ LL + G + + +G +
Sbjct: 107 AGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL-ENGANQSTATEDGFT 165
Query: 766 ALAIALEAEQDEVAALLHAHLSSGQ 790
LA+AL+ ++ A+L + + G+
Sbjct: 166 PLAVALQQGHNQAVAILLENDTKGK 190
Score = 67.0 bits (162), Expect = 7e-11
Identities = 51/154 (33%), Positives = 78/154 (50%), Gaps = 8/154 (5%)
Query: 617 NLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDM 676
N+ G T LH + G+ + +LLLD GA ++ ++G ++L LAA +E+ +
Sbjct: 656 NIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-NIHMSTKSGLTSLHLAA------QEDKV 708
Query: 677 AVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCA 736
V L G ++ G T L++A +G MV LL GA+VNA+ +G T L A
Sbjct: 709 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768
Query: 737 SEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIA 770
++ G + +LL Q G P G +ALAIA
Sbjct: 769 AQQGHTHIINVLL-QHGAKPNATTANGNTALAIA 801
Score = 60.8 bits (146), Expect = 5e-09
Identities = 65/240 (27%), Positives = 100/240 (41%), Gaps = 32/240 (13%)
Query: 576 VRLVAQEWFRVSSQRRSQAEP--VARMLEGVRRLGPELLAHVVN--LADGNGNTALHYSV 631
VR + + V ++ R + P +A L G + LL H+ + A NG T LH S
Sbjct: 480 VRCLLRNGALVDARAREEQTPLHIASRL-GKTEIVQLLLQHMAHPDAATTNGYTPLHISA 538
Query: 632 SHGNLAIASLLLDTGACEVNRQNR--------AGYSALMLAALTSVRQEEEDMA------ 677
G + +AS+LL+ GA + A Y +L +A L R+ D A
Sbjct: 539 REGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLT 598
Query: 678 ------------VVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQ 725
V L G ++ G T L +A + + +TLL GA+ N
Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIV 658
Query: 726 DADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAH 785
G T L AS+ G D V LLL + G + + G ++L +A + ++ VA +L H
Sbjct: 659 TKQGVTPLHLASQEGHTDMVTLLLDK-GANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717
Score = 52.0 bits (123), Expect = 2e-06
Identities = 46/160 (28%), Positives = 72/160 (45%), Gaps = 8/160 (5%)
Query: 623 GNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRL 682
G TALH + G + + LL GA V+ + R + L +A+ + +VQ L
Sbjct: 464 GETALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTE------IVQLL 516
Query: 683 FCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRL 742
A+ G T L ++ G+ D+ + LL GA + G T L A++YG L
Sbjct: 517 LQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL 576
Query: 743 DTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALL 782
D +LLL + + N G + L +A + +VA LL
Sbjct: 577 DVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLL 615
Score = 48.9 bits (115), Expect = 2e-05
Identities = 47/167 (28%), Positives = 68/167 (40%), Gaps = 14/167 (8%)
Query: 626 ALHYSVSHGNLAIASLLLDT-------GACEVNRQNRAGYSALMLAALTSVRQEEEDMAV 678
ALH + + A+LLL VNR +G++ L +AA ++ V
Sbjct: 195 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA------HYGNVNV 248
Query: 679 VQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASE 738
L G ++ G T L +A G +MV LL G ++A+ DG T L CA+
Sbjct: 249 ATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 308
Query: 739 YGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAH 785
G V LLL + G G S L +A + + E L H
Sbjct: 309 SGHDQVVELLL-ERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Score = 48.1 bits (113), Expect = 3e-05
Identities = 39/117 (33%), Positives = 58/117 (49%), Gaps = 9/117 (7%)
Query: 602 EGVRRLGPELLAH--VVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYS 659
EG L ELL V+ A GNTALH + G + +L+ GA +N Q++ G++
Sbjct: 74 EGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGA-NINAQSQNGFT 132
Query: 660 ALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLL 716
L +AA +E + VV+ L G + A++ G T L +A+ G VA LL
Sbjct: 133 PLYMAA------QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Score = 48.1 bits (113), Expect = 3e-05
Identities = 39/134 (29%), Positives = 65/134 (48%), Gaps = 9/134 (6%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
++++ +G T+LH + + +A +L GA + + + GY+ L++A +
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGA-DQDAHTKLGYTPLIVAC------HYGN 740
Query: 676 MAVVQRLFCMG-DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALM 734
+ +V L G +VNAK ++ G T L A G ++ LL GA NA A+G TAL
Sbjct: 741 VKMVNFLLKQGANVNAK-TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALA 799
Query: 735 CASEYGRLDTVRLL 748
A G + V L
Sbjct: 800 IAKRLGYISVVDTL 813
Score = 33.9 bits (76), Expect = 0.63
Identities = 48/193 (24%), Positives = 73/193 (37%), Gaps = 39/193 (20%)
Query: 622 NGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQR 681
+G T LH + G+ + LLL+ GA + R + G S L +AA + + + V+
Sbjct: 298 DGLTPLHCAARSGHDQVVELLLERGAPLLAR-TKNGLSPLHMAA------QGDHVECVKH 350
Query: 682 LFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGR 741
L + TAL +A G + LL A+ NA+ +G T L A + R
Sbjct: 351 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 410
Query: 742 LDTVR--------------------------------LLLTQPGCDPAILDNEGTSALAI 769
+ + LLL Q G P + + G +AL +
Sbjct: 411 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 470
Query: 770 ALEAEQDEVAALL 782
A A Q EV L
Sbjct: 471 AARAGQVEVVRCL 483
Score = 33.9 bits (76), Expect = 0.63
Identities = 84/406 (20%), Positives = 147/406 (36%), Gaps = 70/406 (17%)
Query: 226 AGRAQPEPDGEAETRPDKLAQLRRLTERLATSERGGRARASPRADSPDGLAAGRSEGALQ 285
A + Q + + + T + L E ++ G ++ SP GL E AL
Sbjct: 2360 AHKTQTDSEVQESTATSDETKALPLPEASVKTDTGTESKPQGVIRSPQGL-----ELALP 2414
Query: 286 VLDGEVGSL---DGTPQTREVAAEAVPETREAGAQAVPETREAG----------VEAAPE 332
D EV S D + + + EA P + + P++ E +E++P
Sbjct: 2415 SRDSEVLSAVADDSLAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPV 2474
Query: 333 TVEADAWVTEALLGLPAAAERELELLRASLEHQRGVSELLRGRLRELEEAREAAEEAAAG 392
+ A + + LPAA + ELL +E+ R R L + +AE+ +
Sbjct: 2475 EPKMKAGIFPSHFPLPAAVAKT-ELL----------TEVASVRSRLLRDPDGSAEDDSL- 2522
Query: 393 ARAQLREATTQTPWSCAEKAAQTESPAEAPSLTQESSPGSMDGDRAVAPAGILKSIMKKR 452
+ L E++ ++P S +++ S P T S+P PA ++ ++
Sbjct: 2523 EQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDVSTP---------KPA-VIHECAEED 2572
Query: 453 DGTPGAQPSSGPKSLQFVGVLN------------------GEYESSSSEDASDSDGDSEN 494
D G + P+ F V E + S +SD D D
Sbjct: 2573 DSENGEKKRFTPEEEMFKMVTKIKMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSV 2632
Query: 495 GGAEPPGSSSGSGDDSGGGSDSGTPGPPSGGDIRDPEPEAEAEPQQVAQGRCELSPRLRE 554
EP +GSG+D +SG P + + R +E+EP+ + S L E
Sbjct: 2633 DVDEP--KHTGSGED-----ESGVPVLVT-SESRKVSSSSESEPELAQLKKGADSGLLPE 2684
Query: 555 ACVALQRQLSRPRGVASDGGAVRL----VAQEWFRVSSQRRSQAEP 596
+ +Q P + S+ + V + + +Q EP
Sbjct: 2685 PVIRVQPPSPLPSSMDSNSSPEEVQFQPVVSKQYTFKMNEDTQEEP 2730
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 68.6 bits (166), Expect = 2e-11
Identities = 58/187 (31%), Positives = 91/187 (48%), Gaps = 12/187 (6%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
VNL D +GNTAL + G+ I LLD G VN +R+G + L+ A E
Sbjct: 229 VNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY-VNIPDRSGDTVLIGAVRGG--HVEIV 285
Query: 676 MAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMC 735
A++Q+ D++ + Q +TAL A+ G MV +L C D DG T L+
Sbjct: 286 RALLQKY---ADIDIRG-QDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIK 341
Query: 736 ASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSG----QP 791
A++ ++ V LLL + G + +D +G + L IA+ ++A LL + G +P
Sbjct: 342 ATKMRNIEVVELLLDK-GAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRP 400
Query: 792 DTQSESP 798
+ E+P
Sbjct: 401 NKAGETP 407
Score = 55.1 bits (131), Expect = 3e-07
Identities = 50/157 (31%), Positives = 75/157 (47%), Gaps = 8/157 (5%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
VN +D G T L ++ G+L LL GA +V+++ +AL++A Q ++
Sbjct: 163 VNCSDKYGTTPLVWAARKGHLECVKHLLAMGA-DVDQEGANSMTALIVAVKGGYTQSVKE 221
Query: 676 MAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMC 735
+ L +VN + G TALM+A G ++V LL G VN D G T L+
Sbjct: 222 I-----LKRNPNVNL-TDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIG 275
Query: 736 ASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALE 772
A G ++ VR LL Q D I + +AL A+E
Sbjct: 276 AVRGGHVEIVRALL-QKYADIDIRGQDNKTALYWAVE 311
Score = 54.3 bits (129), Expect = 4e-07
Identities = 47/154 (30%), Positives = 70/154 (45%), Gaps = 8/154 (5%)
Query: 629 YSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDV 688
++ G+ I LLL GA +VN ++ G + L+ AA + + V+ L MG
Sbjct: 143 WAAGRGHADIVHLLLQNGA-KVNCSDKYGTTPLVWAA------RKGHLECVKHLLAMGAD 195
Query: 689 NAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLL 748
+ TAL++A+ G V +L +VN D DG TALM AS+ G + V+ L
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
Query: 749 LTQPGCDPAILDNEGTSALAIALEAEQDEVAALL 782
L G I D G + L A+ E+ L
Sbjct: 256 L-DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRAL 288
Score = 50.1 bits (118), Expect = 8e-06
Identities = 41/127 (32%), Positives = 66/127 (51%), Gaps = 2/127 (1%)
Query: 659 SALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLAC 718
S L+ ++ + +EE A+ L DV+ + ++ GQT LM+A G ++V L+
Sbjct: 2 SVLISQSVINYVEEENIPALKALLEKCKDVDER-NECGQTPLMIAAEQGNLEIVKELIKN 60
Query: 719 GADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEV 778
GA+ N +D D TAL+ AS+ G + V LL + G + D G +AL A + +V
Sbjct: 61 GANCNLEDLDNWTALISASKEGHVHIVEELL-KCGVNLEHRDMGGWTALMWACYKGRTDV 119
Query: 779 AALLHAH 785
LL +H
Sbjct: 120 VELLLSH 126
Score = 49.7 bits (117), Expect = 1e-05
Identities = 46/148 (31%), Positives = 66/148 (44%), Gaps = 8/148 (5%)
Query: 623 GNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRL 682
G T L + GNL I L+ GA N ++ ++AL+ A+ +E + +V+ L
Sbjct: 38 GQTPLMIAAEQGNLEIVKELIKNGA-NCNLEDLDNWTALISAS------KEGHVHIVEEL 90
Query: 683 FCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRL 742
G G TALM A GR D+V LL+ GA+ + ++ A+ G
Sbjct: 91 LKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHA 150
Query: 743 DTVRLLLTQPGCDPAILDNEGTSALAIA 770
D V LLL Q G D GT+ L A
Sbjct: 151 DIVHLLL-QNGAKVNCSDKYGTTPLVWA 177
Score = 49.3 bits (116), Expect = 1e-05
Identities = 53/162 (32%), Positives = 75/162 (46%), Gaps = 21/162 (12%)
Query: 617 NLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNR--AGYSALMLAALTSVRQEEE 674
NL D + TAL + G++ I LL C VN ++R G++ALM A
Sbjct: 65 NLEDLDNWTALISASKEGHVHIVEELLK---CGVNLEHRDMGGWTALMWACYKGRTD--- 118
Query: 675 DMAVVQRLFCMGDVNAKASQTGQTA---LMLAISHGRQDMVATLLACGADVNAQDADGAT 731
VV+ L G A S TG + ++ A G D+V LL GA VN D G T
Sbjct: 119 ---VVELLLSHG---ANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTT 172
Query: 732 ALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEA 773
L+ A+ G L+ V+ LL G D +D EG +++ + A
Sbjct: 173 PLVWAARKGHLECVKHLLAM-GAD---VDQEGANSMTALIVA 210
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 65.9 bits (159), Expect = 1e-10
Identities = 82/319 (25%), Positives = 131/319 (41%), Gaps = 36/319 (11%)
Query: 478 ESSSSEDASDSDGDSENGGAEPPGSSSGSGDDSGGGSDSGT-PGPPSGGDIRDPEPEAEA 536
ESS +++ + + D+ + PG GS + + +G+ GPP D + +
Sbjct: 633 ESSKAKEVTIAKADTTSTVTPVPGQEKGSALEGRADTTTGSAAGPPLSED-----DKLQG 687
Query: 537 EPQQVAQGRCELSPRLREACVALQRQLSRPRGVASDGGAVRLVAQEWFRVSSQRRSQAEP 596
V +G P L RP S G + + S++ +
Sbjct: 688 AASHVPEGFDPTGP----------AGLGRPTPGLSQGPGKETLESALIALDSEKPKKLRF 737
Query: 597 VARMLEGVRRLGPELLAHVVNLADG----------NGNTALHYSVSHGNLAIASLLLDTG 646
+ L R G EL ++ L DG N + LH + G++ I +L+ G
Sbjct: 738 HPKQLYFSARQG-ELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAG 796
Query: 647 ACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISH 706
A ++ + + LM AA E + V+ L G + G T L LA
Sbjct: 797 A-NIDTCSEDQRTPLMEAA------ENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKK 849
Query: 707 GRQDMVATLLACG-ADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTS 765
G ++V LL+ G DVN QD G T ++ A+EY +D V+LLL++ G D I DNE
Sbjct: 850 GHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSK-GSDINIRDNEENI 908
Query: 766 ALAIALEAEQDEVAALLHA 784
L A + ++A +L A
Sbjct: 909 CLHWAAFSGCVDIAEILLA 927
Score = 55.5 bits (132), Expect = 2e-07
Identities = 49/182 (26%), Positives = 81/182 (44%), Gaps = 9/182 (4%)
Query: 615 VVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEE 674
+V+ D G+T LH + G+ + LL G +VN Q+ G++ ++ A E +
Sbjct: 831 LVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWAT------EYK 884
Query: 675 DMAVVQRLFCMG-DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATAL 733
+ +V+ L G D+N + ++ L A G D+ LLA D++A + G + L
Sbjct: 885 HVDLVKLLLSKGSDINIRDNEE-NICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPL 943
Query: 734 MCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDT 793
A+ R D V L L++ D + + EG + L A Q A + L PD
Sbjct: 944 HIAARENRYDCVVLFLSRDS-DVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDR 1002
Query: 794 QS 795
S
Sbjct: 1003 PS 1004
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 65.5 bits (158), Expect = 2e-10
Identities = 149/619 (24%), Positives = 231/619 (37%), Gaps = 97/619 (15%)
Query: 15 GPRLCPVPAAGGARSPSSPYSVETPYG---------FHLDLDFLKYIEELERGPAARRAP 65
G CP A R SP S + G F L + E G AA AP
Sbjct: 1653 GEEFCPCEAC--VRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAP 1710
Query: 66 GPPTSRRPRAPRP--GLAGARSPGAWTSSESLASDDGGAPGILSQGAPSGLLMQPLSPRA 123
G T P + R G G PG +DG L++ L A
Sbjct: 1711 GK-THTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMA 1769
Query: 124 PVRNPRVEHTLRETSRRLELAQTH-------ERAPSPGRG-----------VPRSPRGSG 165
R + ++ ETS EL + ER + G+G + G
Sbjct: 1770 QEREGKTHNS--ETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPG 1827
Query: 166 RSSPAPNL-APASPGPAQLQLVREQMAAALRRLRELEDQARTLPELQEQVRALRAEKARL 224
+S A + AP + G AQ + + A +E E +A+ PE E V A AE
Sbjct: 1828 QSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQ--PE-SEDVEAPEAE---- 1880
Query: 225 LAGRAQPE------PDGEAETRPDKLAQLRRLTERLATSERGG-RARASPRADSPD--GL 275
G AQPE P+ E E +P+ E+ A E A + D P+ G
Sbjct: 1881 --GEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGA 1938
Query: 276 AAGRSEGALQVLDGEVGSLDGTPQTREVAAEAVPETREAGAQAVP-ETREAGVEAAPETV 334
A +E A Q +G+ +++E EA PE+ + A V ET+EA EA PE+
Sbjct: 1939 EAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESE 1998
Query: 335 EADAWVTEA-LLGLPAAAERELELLRASLEHQRGVSELLRGRLRELE----------EAR 383
+ +A E + A+ E + + A + + ++ + G ++ E EA
Sbjct: 1999 DVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAP 2058
Query: 384 EAAEEAAAGARAQLREATTQT-----------------PWSCAEKAAQTESPA------E 420
EA EEA A +++EA + P S +A + E A E
Sbjct: 2059 EAEEEAQE-AEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE 2117
Query: 421 APSLTQESSPGS--MDGDRAVAPAGILKSIMKKRDGTPGAQPSS-GPKSLQFVGVLNGEY 477
AP E+ P S ++ A A ++ +D AQP S G ++ + E
Sbjct: 2118 APETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPEL 2177
Query: 478 ESSSSEDASDSDGDSENGGAEPPGSSSGSGDDSGG----GSDSGTPGPPSGGDIRDPEPE 533
E + +A + + E+ G E P + + + G ++ P G + + E E
Sbjct: 2178 EGVEAPEA-EGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGE 2236
Query: 534 AEAEPQQVAQGRCELSPRL 552
A+ E + QG + SP++
Sbjct: 2237 AQPESEGETQGEKKGSPQV 2255
Score = 62.8 bits (151), Expect = 1e-09
Identities = 103/434 (23%), Positives = 153/434 (35%), Gaps = 45/434 (10%)
Query: 125 VRNPRVEHTLRETSRRLELAQTHERAPSPGRGVPRSPRGSGRSSPAPNLAPASPGPAQLQ 184
V P E ++ S E + + A V + G P A A Q
Sbjct: 1890 VETPEAEWEVQPESEGAEAPEAEKEAQPETESV-EALETEGEDEPESEGAEAQEAEEAAQ 1948
Query: 185 LVREQMAAALRRLRELEDQARTLPELQEQVRALRAE-KARLLAGRAQPEPDGEAETRPDK 243
Q + E + PE E V AL E + + G AQPE E P+
Sbjct: 1949 EAEGQTQPESEVIESQEAEEEAQPE-SEDVEALEVEVETQEAEGEAQPE--SEDVEAPEA 2005
Query: 244 LAQLRRLTERLATSERGGRARASPRADSPDGLAAGRSEGALQVLDGEVGSLDGTPQTREV 303
+++ E A P +D + E A +V +GE +G Q
Sbjct: 2006 EGEMQEAEEE-----------AQPESDGVEAQPKSEGEEAQEV-EGETQKTEGDAQPESD 2053
Query: 304 AAEAVPETREAGAQAVPETREAGVEAAPETVEADAWVTEALLGLPAAAERELELLRASLE 363
EA PE E +A E +EA EA PE+ + DA E P + E +
Sbjct: 2054 GVEA-PEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGE-AQPESEGVEAPEAEGEAQ 2111
Query: 364 HQRGV-SELLRGRLR------ELEEAREAAEEAAAGARAQLREATTQTPWSCAEKAAQTE 416
G+ + G + E EA A+ + G AQ E Q P S +A + E
Sbjct: 2112 KAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQ-PESEGIEAQEAE 2170
Query: 417 SPA-------EAPSLTQESSPGSMDGDRAVAPAGILKSIMKKRDGTPGAQPSSGPKSLQF 469
A EAP E+ P S +G A G + ++ + P A+ + P+
Sbjct: 2171 EEAQPELEGVEAPEAEGEAQPES-EGIEAPEAEGEAQPELEGVEA-PEAEEEAQPEP--- 2225
Query: 470 VGVLNGEYESSSSEDASDSDGDSENGGAEPPGSSSGSGDDSGGGS-----DSGTPGPPSG 524
GV E E + + S+ + E G+ G +++ S D TP P G
Sbjct: 2226 EGVETPEAEGEAQPE-SEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPG 2284
Query: 525 GDIRDPEPEAEAEP 538
GD P ++ P
Sbjct: 2285 GDTPHQRPGSQTGP 2298
Score = 38.1 bits (87), Expect = 0.033
Identities = 137/579 (23%), Positives = 191/579 (32%), Gaps = 93/579 (16%)
Query: 67 PPTSRRPRAPRPGLAGARSPGAWTSSESLASDD-GGAPGILSQGAPSGLLMQ--PLSPRA 123
P +S PR P G+ A SP A +E A G PG+ GA G Q L+PRA
Sbjct: 467 PESSCCPRTPEDGVDSA-SPSAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRA 525
Query: 124 PVRNPRVEHTLRETSRRLELAQTHERAPSPGRGVPRSPRGSGRSSPAPNLAPASPGPAQL 183
+ T +HE + G G P+ G R+ + A PA
Sbjct: 526 RSEEGASSDSSASTG-------SHEGSSEWG-GRPQGCPGKARAETSQQEASEGGDPA-- 575
Query: 184 QLVREQMAAALRRLRELEDQARTLPELQEQVRALRAEKARLLAGRAQPEPDGEAETRPDK 243
A +L LR + QA T + EQ + L+ G + A + P
Sbjct: 576 -----SPALSLSSLRSDDLQAETQGQGTEQATGAAVTREPLVLGLSCSWDSEGASSTPST 630
Query: 244 LAQLRRLTERLATSERGGRARASPRADSPDGLAAGR------------SEGALQVLDGEV 291
++ +R R+RAS + SP GR + LD V
Sbjct: 631 CTSSQQ-------GQRRHRSRASAMS-SPSSPGLGRVAPRGHPRHSHYRKDTHSPLDSSV 682
Query: 292 GSLDGTPQTREVAAEAVPETREAGAQAVPETREAGVEAAPETVEADAWVTEALLGLPAAA 351
P R A + R +G+ + T+ +G P + + ++ LLG +A
Sbjct: 683 TKQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLRPP---SSGSLPSQDLLGTSSAT 739
Query: 352 ERELELLRASLEHQRGVSELLRGRLRELEEAREAAEEAAAGAR-AQLREATTQTPWSCAE 410
+ GVS A A AG+R T SC++
Sbjct: 740 VTP----AVHSDFVSGVSP---------HNAPSAGWAGDAGSRTCSPAPIPPHTSDSCSK 786
Query: 411 KAAQTESPAEAPSLTQESSPGSMDGDRAVAPA-GILKSIMKKRDGTPGAQPSS---GPKS 466
A + EA Q SSP + R A G +S + GT AQ + P++
Sbjct: 787 SGAASLG-EEARDTPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEAQRGPSPEA 845
Query: 467 LQFVGVL-----NGEYESSSSEDASDSDGDSENGGAEPPGSSSGSGDDSGGGSDSGTPGP 521
G G + S G S A PG S G G + S PGP
Sbjct: 846 SWLCGRYCPTPPRGRPCPQRRSSSCGSTGSSHQSTARGPGGSPQEGTRQPGPTPS--PGP 903
Query: 522 PSGGDIRDPEPEAEAEPQQVAQGRCELSPRLREACVALQRQLSRPRGVASDGGAVRLVAQ 581
SG R +QG A R LS + + S GG
Sbjct: 904 NSGASRR----------SSASQG-------------AGSRGLSEEKTLRSGGGPQGQEEA 940
Query: 582 EWFRVSSQRRSQAEPVARMLEGVRRLGPELLAHVVNLAD 620
SS RS E V R E + + E + LAD
Sbjct: 941 SGVSPSSLPRSSPEAVVR--EWLDNIPEEPILMTYELAD 977
Score = 35.0 bits (79), Expect = 0.28
Identities = 63/245 (25%), Positives = 81/245 (33%), Gaps = 51/245 (20%)
Query: 344 LLGLPAAAERELEL--LRASLEHQRGVSELLRGRLRELEEAREAAEEAAAGARAQLREAT 401
L L A +ER L L L +LE + +S L +L E EA E A +R+
Sbjct: 1613 LRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGE-----EAEGEEFCPCEACVRKKV 1667
Query: 402 TQTPWSCAEKAAQTESPA----EAPSLTQESSPGSMDGDRAVAPAGILKSIMKKRDGTPG 457
+ P S T P + + Q DG+ A G + G
Sbjct: 1668 S--PMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQG 1725
Query: 458 AQPSSGPKSLQFVGVLNGEYESSSSEDASDSD-------GD------------------S 492
A+ GP Q GV GE S D D GD S
Sbjct: 1726 AEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGS 1785
Query: 493 ENGGAEPPG---SSSGSGDDSGGGSDSGTPGPPSGGDIRDP----------EPEAEAEPQ 539
E G AE G S G G G + G + G +DP PEAE E Q
Sbjct: 1786 ELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQ 1845
Query: 540 QVAQG 544
++G
Sbjct: 1846 PESEG 1850
Score = 34.7 bits (78), Expect = 0.37
Identities = 74/336 (22%), Positives = 120/336 (35%), Gaps = 40/336 (11%)
Query: 223 RLLAGRAQPEPDGEA-ETRPDKLAQLRRLTERLATSERGGRARASPRADSPDGLAAGRSE 281
++L + DGEA E P K T + +E G S +G S+
Sbjct: 1691 QILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQ 1750
Query: 282 GALQVLDGEVGSLDGTPQTREVAAEAVPETREAGAQAVPETREA-GVEAAPETVEADAWV 340
+ D ++G +G +E + AG++ +E G+ ET +
Sbjct: 1751 RLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGH 1810
Query: 341 TEALLGLPAAAERELELLRASLEHQRGVSELLRGRLRELEEAREAAEEAAAGARAQLREA 400
+ L G AA + G S+ G E EA A+ + G A E
Sbjct: 1811 EDNLQGEAAAGG----------DQDPGQSDGAEGI--EAPEAEGEAQPESEGVEAPEAEG 1858
Query: 401 TTQTPWSCAEKAAQTESP-AEAPSLTQESSPGSMDGDRAVAPAGILKSIMKKRDGTPGAQ 459
Q AE AQ ES EAP E+ P S D + A + + + GA+
Sbjct: 1859 DAQE----AEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEV-------QPESEGAE 1907
Query: 460 PSSGPKSLQFVGVLNGEYESSSSEDASDSDGDSENGGAEPPGSSSGSGDDSGGGSDSGTP 519
K Q + S +A +++G+ E E G+ + +++ ++ T
Sbjct: 1908 APEAEKEAQ---------PETESVEALETEGEDE---PESEGAEAQEAEEAAQEAEGQTQ 1955
Query: 520 GPPSGGDIRDPEPEAEAEPQQVAQGRCELSPRLREA 555
P I E E EA+P+ E+ +EA
Sbjct: 1956 --PESEVIESQEAEEEAQPESEDVEALEVEVETQEA 1989
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 65.1 bits (157), Expect = 3e-10
Identities = 53/163 (32%), Positives = 77/163 (47%), Gaps = 8/163 (4%)
Query: 620 DGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVV 679
D G TA H + HG L L+ +G C+ N +++ G +AL LAA MAV+
Sbjct: 156 DKLGRTAFHRAAEHGQLDALDFLVGSG-CDHNVKDKEGNTALHLAA------GRGHMAVL 208
Query: 680 QRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEY 739
QRL +G + + G TAL A D V LL G+ VNA + L A+
Sbjct: 209 QRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALS 268
Query: 740 GRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALL 782
G D R+L+ GC ++D++G S L +A+ + LL
Sbjct: 269 GSEDVSRVLIHAGGC-ANVVDHQGASPLHLAVRHNFPALVRLL 310
Score = 60.1 bits (144), Expect = 8e-09
Identities = 50/166 (30%), Positives = 73/166 (43%), Gaps = 8/166 (4%)
Query: 617 NLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDM 676
N+ D GNTALH + G++A+ L+D G ++ QN G +AL AA S
Sbjct: 186 NVKDKEGNTALHLAAGRGHMAVLQRLVDIGL-DLEEQNAEGLTALHSAAGGSHPD----- 239
Query: 677 AVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCA 736
VQ L G +Q + L A G +D+ L+ G N D GA+ L A
Sbjct: 240 -CVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLA 298
Query: 737 SEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALL 782
+ VRLL+ D +DN + L +A E ++A +L
Sbjct: 299 VRHNFPALVRLLINSDS-DVNAVDNRQQTPLHLAAEHAWQDIADML 343
Score = 50.8 bits (120), Expect = 5e-06
Identities = 39/135 (28%), Positives = 57/135 (42%), Gaps = 9/135 (6%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
VN + LHY+ G+ ++ +L+ G C N + G S L LA +
Sbjct: 251 VNALTQKNLSCLHYAALSGSEDVSRVLIHAGGC-ANVVDHQGASPLHLAV-------RHN 302
Query: 676 MAVVQRLFCMGDVNAKA-SQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALM 734
+ RL D + A QT L LA H QD+ LL G D+N +D G TAL
Sbjct: 303 FPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALA 362
Query: 735 CASEYGRLDTVRLLL 749
A + V +++
Sbjct: 363 VAVRSNHVSLVDMII 377
Score = 40.0 bits (92), Expect = 0.009
Identities = 56/238 (23%), Positives = 82/238 (34%), Gaps = 86/238 (36%)
Query: 610 ELLAHVVNLADGN--GNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALT 667
EL+ VN N G ALH++ G+ LLL+ A V+ ++ G ALT
Sbjct: 33 ELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAA-VDEEDAVG-------ALT 84
Query: 668 SVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDA 727
R C G AL+L+ G ++ L+ GA ++ +
Sbjct: 85 EAR------------LCFG----------MNALLLSAWFGHLRILQILVNSGAKIHCESK 122
Query: 728 DGATALMC-----------------------------------ASEYGRLDTVRLLLTQP 752
DG T L C A+E+G+LD + L+
Sbjct: 123 DGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGS- 181
Query: 753 GCDPAILDNEGTSALAIA------------------LEAEQDEVAALLHAHLSSGQPD 792
GCD + D EG +AL +A LE + E LH+ PD
Sbjct: 182 GCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPD 239
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 64.7 bits (156), Expect = 3e-10
Identities = 88/312 (28%), Positives = 122/312 (39%), Gaps = 40/312 (12%)
Query: 501 GSSSGSGDDSGGGSDSGTPGPPSGGDIRDPEPEAEAEPQQVAQGRCELSPRLREACVALQ 560
G +SG G GGGS SGT G + D + A G E E+ + Q
Sbjct: 51 GPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQ 110
Query: 561 RQLSRP---------RGVASDGGAVRLVAQEWFRVSSQRRSQA----------EPVARML 601
L P ++G +R V E +Q R +A E + R+
Sbjct: 111 EDLDNPVLKTTSEIFLSSTAEGADLRTVDPE-----TQARLEALLEAAAFADPEVLRRLT 165
Query: 602 EGVRRLGPELLAHVVNLADGNGNTA-------LHYSVSHGNLAIASLLLDTGACEVNRQN 654
V E A + + N + A L + S G++ LLD G VN
Sbjct: 166 SSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGR-SVNEHT 224
Query: 655 RAGYSALMLAALTSVRQEEEDMAVVQRLFCM-GDVNAKASQTGQTALMLAISHGRQDMVA 713
G S L LA + + Q L M +V + ++ T LM A S G D+V
Sbjct: 225 EEGESLLCLACSAGYYE------LAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVK 278
Query: 714 TLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEA 773
LL ADVN+Q A G TAL A G +D V++LL + G + + G + L A A
Sbjct: 279 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE-GANIEDHNENGHTPLMEAASA 337
Query: 774 EQDEVAALLHAH 785
EVA +L H
Sbjct: 338 GHVEVARVLLDH 349
Score = 61.2 bits (147), Expect = 4e-09
Identities = 56/168 (33%), Positives = 80/168 (47%), Gaps = 9/168 (5%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
VN GNTAL Y+ + G + I +LL+ GA + N G++ LM AA
Sbjct: 287 VNSQSATGNTALTYACAGGFVDIVKVLLNEGA-NIEDHNENGHTPLMEAASAG------H 339
Query: 676 MAVVQRLFCMG-DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALM 734
+ V + L G +N +++ ++AL LA G DMV LL GAD + + TALM
Sbjct: 340 VEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALM 399
Query: 735 CASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALL 782
A G ++ RLLL G + + S L +A E+AALL
Sbjct: 400 EACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVELAALL 446
Score = 53.9 bits (128), Expect = 6e-07
Identities = 52/171 (30%), Positives = 77/171 (45%), Gaps = 39/171 (22%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
VN+ + + L + G++ +A+LL++ GA + N GY+ LM AA R+ E+
Sbjct: 420 VNMPADSFESPLTLAACGGHVELAALLIERGA-NLEEVNDEGYTPLMEAA----REGHEE 474
Query: 676 MAVVQRLFCMG-DVNAKASQTGQTALMLAI------------------------------ 704
M + L G ++NA+ +T +TAL LA
Sbjct: 475 MVAL--LLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEAS 532
Query: 705 SHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCD 755
G ++V LLA GA+V+A A G TAL A E G D +LL Q G D
Sbjct: 533 QEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLL-QAGAD 582
Score = 46.2 bits (108), Expect = 1e-04
Identities = 57/201 (28%), Positives = 83/201 (41%), Gaps = 29/201 (14%)
Query: 611 LLAHVVNLADGN--GNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAA--- 665
LL N+ D N G+T L + S G++ +A +LLD GA N SAL LA
Sbjct: 313 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 372
Query: 666 -LTSVR----------QEEEDMAVVQRLFCMG----------DVNAKASQTG---QTALM 701
L VR + ++M CM D A+ + ++ L
Sbjct: 373 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 432
Query: 702 LAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDN 761
LA G ++ A L+ GA++ + +G T LM A+ G + V LLL Q A +
Sbjct: 433 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
Query: 762 EGTSALAIALEAEQDEVAALL 782
+AL +A EVA L
Sbjct: 493 TQETALTLACCGGFSEVADFL 513
Score = 40.0 bits (92), Expect = 0.009
Identities = 45/168 (26%), Positives = 68/168 (40%), Gaps = 17/168 (10%)
Query: 566 PRGVASDGGAVRLVAQEWFRVSSQRRSQAEPVARMLEGVRRLGPE----LLAHVVNL--- 618
P +A+ GG V L A R ++ E ++E R E LLA N+
Sbjct: 430 PLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 489
Query: 619 ADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAV 678
+ TAL + G +A L+ GA G S ++ A +E + +
Sbjct: 490 TEETQETALTLACCGGFSEVADFLIKAGA-----DIELGCSTPLMEA-----SQEGHLEL 539
Query: 679 VQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQD 726
V+ L G + TG TAL A +G D+ LL GAD++ Q+
Sbjct: 540 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 587
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 64.3 bits (155), Expect = 4e-10
Identities = 71/231 (30%), Positives = 107/231 (46%), Gaps = 14/231 (6%)
Query: 545 RCELSPRLREACVALQRQLSRPRGVASDGGA--VRLVAQEWFRVSSQRRSQAEPVARMLE 602
R L PR E C+ + +++ + + G VRL+ V Q S P+ +
Sbjct: 346 RKNLVPRDEELCI-YENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQ 404
Query: 603 GVRR-LGPELLAHVV--NLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYS 659
+ L LLAH N D +G LH++ +G+ A LLLD GAC V+ Q R G++
Sbjct: 405 DQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGAC-VDAQEREGWT 463
Query: 660 ALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACG 719
L LAA + E +V R D N ++ G+T L +A G +V L + G
Sbjct: 464 PLHLAAQNNF--ENVARLLVSR---QADPNLHEAE-GKTPLHVAAYFGHVSLVKLLTSQG 517
Query: 720 ADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIA 770
A+++AQ + T L A E G++ ++ LL + G P LD G L A
Sbjct: 518 AELDAQQRNLRTPLHLAVERGKVRAIQHLL-KSGAVPDALDQSGYGPLHTA 567
Score = 50.8 bits (120), Expect = 5e-06
Identities = 36/96 (37%), Positives = 51/96 (53%), Gaps = 2/96 (2%)
Query: 687 DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVR 746
DV+ + + +G T L++A + D+ A LLA GAD N D DG L A++ G T R
Sbjct: 387 DVDCQTA-SGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTAR 445
Query: 747 LLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALL 782
LLL C A + EG + L +A + + VA LL
Sbjct: 446 LLLDHGACVDA-QEREGWTPLHLAAQNNFENVARLL 480
Score = 48.5 bits (114), Expect = 2e-05
Identities = 51/168 (30%), Positives = 75/168 (44%), Gaps = 18/168 (10%)
Query: 576 VRLVAQEWFRVSSQRRSQAEPVARMLE-GVRRLGPELLAH--VVNLADGNGNTALHYSVS 632
V+L+ + + +Q+R+ P+ +E G R LL V + D +G LH + +
Sbjct: 510 VKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAA 569
Query: 633 HGNLAIASLLLDTGACEVNRQNRAGYSALMLAA----LTSVRQEEEDMAVVQRLFCMGDV 688
G I +LL GA + G++ L LAA L + E A + +G V
Sbjct: 570 RGKYLICKMLLRYGA-SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHA---NMGALGAV 625
Query: 689 NAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCA 736
N T L LA HG + +V+ LL CGAD NA + G T L A
Sbjct: 626 N-------WTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLA 666
Score = 46.2 bits (108), Expect = 1e-04
Identities = 49/187 (26%), Positives = 78/187 (41%), Gaps = 14/187 (7%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
+ L G T LH + G+L I LL ++ A N A+ L + E+
Sbjct: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESHA------NMGALGAVNWTPLHLAARHGEE 639
Query: 676 MAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMC 735
V L C D NA A Q+G T L LA+ V LL A+V+A++ G T
Sbjct: 640 AVVSALLQCGADPNA-AEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHL 698
Query: 736 ASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLH------AHLSSG 789
A+ G +++L+ + G + D + L +AL + + + + L A L
Sbjct: 699 AALKGNTAILKVLV-EAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGGS 757
Query: 790 QPDTQSE 796
+P + E
Sbjct: 758 KPGAEME 764
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/88 (34%), Positives = 42/88 (47%), Gaps = 1/88 (1%)
Query: 698 TALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPA 757
T L ++ G + V LLA DV+ Q A G T L+ A++ + D LLL G D
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH-GADAN 422
Query: 758 ILDNEGTSALAIALEAEQDEVAALLHAH 785
+D +G + L A + D A LL H
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDH 450
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 64.3 bits (155), Expect = 4e-10
Identities = 65/227 (28%), Positives = 104/227 (45%), Gaps = 39/227 (17%)
Query: 620 DGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQ-------- 671
D G TA H + + G++ +++ G +V Q+ G+SAL LAA S +
Sbjct: 50 DSEGKTAFHLAAAKGHVECLRVMITHGV-DVTAQDTTGHSALHLAAKNSHHECIRKLLQS 108
Query: 672 ----EEEDM--------AVVQ------RLFC--MGDVNAKASQTGQTALMLAISHGRQDM 711
E D A Q ++ C +N K G L+LA+ +G ++
Sbjct: 109 KCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLK-DLDGNIPLLLAVQNGHSEI 167
Query: 712 VATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIAL 771
LL GADVN+++ G TALM A E G + V L+ + G D ++D+ G +AL +
Sbjct: 168 CHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALI-KKGADLNLVDSLGYNALHYSK 226
Query: 772 EAEQDEVAALLHAHLSSG-------QPDTQSE-SPPGSQTATPGEGE 810
+E + +LL + +S +P S+ S P S T+TP G+
Sbjct: 227 LSENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPRSITSTPLSGK 273
Score = 44.3 bits (103), Expect = 5e-04
Identities = 30/97 (30%), Positives = 46/97 (47%), Gaps = 1/97 (1%)
Query: 691 KASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLT 750
K G+TA LA + G + + ++ G DV AQD G +AL A++ + +R LL
Sbjct: 48 KHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLL- 106
Query: 751 QPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLS 787
Q C +D+ G +AL A + +L H S
Sbjct: 107 QSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKS 143
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 63.9 bits (154), Expect = 6e-10
Identities = 56/170 (32%), Positives = 81/170 (47%), Gaps = 10/170 (5%)
Query: 623 GNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRL 682
G TALH SVS +L + +L+ GA +V +N G + L +AA + + +A
Sbjct: 190 GWTALHESVSRNDLEVMQILVSGGA-KVESKNAYGITPLFVAAQSGQLEALRFLAKYG-- 246
Query: 683 FCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRL 742
D+N +AS +AL A + +++V LL+ GAD N + DG L AS+ G
Sbjct: 247 ---ADINTQASDNA-SALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNY 302
Query: 743 DTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEV-AALLHAHLSSGQP 791
V++LL P + G S L +A E DEV ALL A P
Sbjct: 303 RIVQMLL--PVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTP 350
Score = 45.4 bits (106), Expect = 2e-04
Identities = 43/166 (25%), Positives = 74/166 (44%), Gaps = 8/166 (4%)
Query: 617 NLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDM 676
++++ + T L+ + N +L+ A +R NR G++AL + D+
Sbjct: 151 DISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNR-GWTALHESV------SRNDL 203
Query: 677 AVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCA 736
V+Q L G + G T L +A G+ + + L GAD+N Q +D A+AL A
Sbjct: 204 EVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEA 263
Query: 737 SEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALL 782
+ + V LL+Q G D + +G L IA + + +L
Sbjct: 264 CKNEHEEVVEFLLSQ-GADANKTNKDGLLPLHIASKKGNYRIVQML 308
Score = 34.3 bits (77), Expect = 0.48
Identities = 30/107 (28%), Positives = 51/107 (47%), Gaps = 3/107 (2%)
Query: 676 MAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMC 735
+ V+QR + G ++ + Q +TA+ LA G D + +LL GA+ + + T L
Sbjct: 106 LKVLQRAY-PGTIDQRTLQE-ETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYK 163
Query: 736 ASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALL 782
A E + V++L+ Q D N G +AL ++ EV +L
Sbjct: 164 ACERKNAEAVKILV-QHNADTNHRCNRGWTALHESVSRNDLEVMQIL 209
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 63.5 bits (153), Expect = 7e-10
Identities = 50/166 (30%), Positives = 78/166 (46%), Gaps = 8/166 (4%)
Query: 617 NLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDM 676
N + G TALH + G + L+ GA +V + + + L ++A R + D
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGA-QVEAKAKDDQTPLHISA----RLGKAD- 513
Query: 677 AVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCA 736
+VQ+L G A+ +G T L L+ G +D+ A LL GA ++ G T L A
Sbjct: 514 -IVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVA 572
Query: 737 SEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALL 782
++YG+L+ LLL Q P G + L +A + +VA LL
Sbjct: 573 AKYGKLEVANLLL-QKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/142 (31%), Positives = 76/142 (53%), Gaps = 7/142 (4%)
Query: 649 EVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGR 708
++N N+ G +AL LA+ +E + VV L A++ G TAL +A G+
Sbjct: 66 DINICNQNGLNALHLAS------KEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQ 119
Query: 709 QDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALA 768
++V L+ GA+VNAQ +G T L A++ L+ V+ LL G ++ +G + LA
Sbjct: 120 AEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDN-GASQSLATEDGFTPLA 178
Query: 769 IALEAEQDEVAALLHAHLSSGQ 790
+AL+ D+V +LL + + G+
Sbjct: 179 VALQQGHDQVVSLLLENDTKGK 200
Score = 62.0 bits (149), Expect = 2e-09
Identities = 52/183 (28%), Positives = 86/183 (46%), Gaps = 10/183 (5%)
Query: 602 EGVRRLGPELLAHVVNLA--DGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYS 659
EG + LL H +L+ G T LH + +G L +A+LLL A + ++G +
Sbjct: 542 EGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP-DAAGKSGLT 600
Query: 660 ALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACG 719
L +AA ++ V L G A++ G T L +A + D+ TLL G
Sbjct: 601 PLHVAA------HYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG 654
Query: 720 ADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVA 779
AD NA G ++ A++ G +D V LLL + + + + G + L +A + ++ VA
Sbjct: 655 ADANAVTRQGIASVHLAAQEGHVDMVSLLLGR-NANVNLSNKSGLTPLHLAAQEDRVNVA 713
Query: 780 ALL 782
+L
Sbjct: 714 EVL 716
Score = 57.4 bits (137), Expect = 5e-08
Identities = 54/190 (28%), Positives = 83/190 (43%), Gaps = 10/190 (5%)
Query: 619 ADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAV 678
A +G T LH + + N +A LLLD GA + + GY+ L +AA ++ M +
Sbjct: 594 AGKSGLTPLHVAAHYDNQKVALLLLDQGASP-HAAAKNGYTPLHIAA------KKNQMDI 646
Query: 679 VQRLFCMG-DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCAS 737
L G D NA Q G ++ LA G DMV+ LL A+VN + G T L A+
Sbjct: 647 ATTLLEYGADANAVTRQ-GIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAA 705
Query: 738 EYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDTQSES 797
+ R++ +L+ Q G G + L + ++ L H + T++
Sbjct: 706 QEDRVNVAEVLVNQ-GAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGY 764
Query: 798 PPGSQTATPG 807
P Q A G
Sbjct: 765 TPLHQAAQQG 774
Score = 52.8 bits (125), Expect = 1e-06
Identities = 54/185 (29%), Positives = 79/185 (42%), Gaps = 18/185 (9%)
Query: 602 EGVRRLGPELLAHVVNL--ADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYS 659
EG + ELL N+ A GNTALH + G + +L+ GA VN Q++ G++
Sbjct: 84 EGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGA-NVNAQSQNGFT 142
Query: 660 ALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACG 719
L +AA +E + VV+ L G + A++ G T L +A+ G +V+ LL
Sbjct: 143 PLYMAA------QENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL--- 193
Query: 720 ADVNAQDADGATALMCASEYGRLDTVR--LLLTQPGCDPAILDNEGTSALAIALEAEQDE 777
D G L R D + LL Q + + G + L IA
Sbjct: 194 ----ENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNIN 249
Query: 778 VAALL 782
VA LL
Sbjct: 250 VATLL 254
Score = 46.6 bits (109), Expect = 9e-05
Identities = 51/187 (27%), Positives = 78/187 (41%), Gaps = 8/187 (4%)
Query: 613 AHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQE 672
A V+ N T LH + GN + LLLD GA +++ + R G + L A + Q
Sbjct: 258 AAAVDFTARNDITPLHVASKRGNANMVKLLLDRGA-KIDAKTRDGLTPLHCGARSGHEQ- 315
Query: 673 EEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATA 732
VV+ L ++ G + L +A + V LL V+ D TA
Sbjct: 316 -----VVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTA 370
Query: 733 LMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPD 792
L A+ G ++LL + +P G + L IA + + +V LL H +S Q
Sbjct: 371 LHVAAHCGHYKVAKVLLDKK-ANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAV 429
Query: 793 TQSESPP 799
T+S P
Sbjct: 430 TESGLTP 436
Score = 43.9 bits (102), Expect = 6e-04
Identities = 39/134 (29%), Positives = 61/134 (45%), Gaps = 9/134 (6%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
VNL++ +G T LH + + +A +L++ GA V+ Q + GY+ L + +
Sbjct: 690 VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGA-HVDAQTKMGYTPLHVGC------HYGN 742
Query: 676 MAVVQRLF-CMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALM 734
+ +V L VNAK ++ G T L A G ++ LL A N +G TAL
Sbjct: 743 IKIVNFLLQHSAKVNAK-TKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALG 801
Query: 735 CASEYGRLDTVRLL 748
A G + V L
Sbjct: 802 IARRLGYISVVDTL 815
Score = 41.6 bits (96), Expect = 0.003
Identities = 41/161 (25%), Positives = 72/161 (44%), Gaps = 8/161 (4%)
Query: 622 NGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQR 681
+G T LH + +GN+ +A+LLL NR ++A V + + +V+
Sbjct: 234 SGFTPLHIAAHYGNINVATLLL-------NRAAAVDFTARNDITPLHVASKRGNANMVKL 286
Query: 682 LFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGR 741
L G ++ G T L G + +V LL A + ++ +G + L A++
Sbjct: 287 LLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDH 346
Query: 742 LDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALL 782
L+ V+LLL Q + N+ +AL +A +VA +L
Sbjct: 347 LNCVQLLL-QHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
Score = 40.4 bits (93), Expect = 0.007
Identities = 41/160 (25%), Positives = 68/160 (42%), Gaps = 8/160 (5%)
Query: 626 ALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCM 685
ALH + + A+LLL + ++++G++ L +AA ++ V L
Sbjct: 205 ALHIAARKDDTKAAALLLQNDN-NADVESKSGFTPLHIAA------HYGNINVATLLLNR 257
Query: 686 GDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTV 745
++ T L +A G +MV LL GA ++A+ DG T L C + G V
Sbjct: 258 AAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVV 317
Query: 746 RLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAH 785
+LL + + N G S L +A + + LL H
Sbjct: 318 EMLLDRAAPILSKTKN-GLSPLHMATQGDHLNCVQLLLQH 356
Score = 38.9 bits (89), Expect = 0.020
Identities = 42/176 (23%), Positives = 71/176 (40%), Gaps = 7/176 (3%)
Query: 622 NGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQR 681
+G T LH G+ + +LLD A + + + G S L +A + + + VQ
Sbjct: 300 DGLTPLHCGARSGHEQVVEMLLDRAA-PILSKTKNGLSPLHMAT------QGDHLNCVQL 352
Query: 682 LFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGR 741
L + TAL +A G + LL A+ NA+ +G T L A + R
Sbjct: 353 LLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNR 412
Query: 742 LDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDTQSES 797
+ + LLL A+ ++ T A + V+ L+H S + + E+
Sbjct: 413 IKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGET 468
>gi|222537750 ankyrin repeat domain 30B [Homo sapiens]
Length = 1392
Score = 63.2 bits (152), Expect = 1e-09
Identities = 57/193 (29%), Positives = 88/193 (45%), Gaps = 8/193 (4%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
+N+ DG G T L ++ A A++L+D GA ++N + G +AL A + E+
Sbjct: 99 LNVLDGEGRTPLMKALQCEREACANILIDAGA-DLNYVDVYGNTALHYAVYS------EN 151
Query: 676 MAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMC 735
+ +V L G V ++ T L+LAI + V LL A+ NA + TALM
Sbjct: 152 LLMVATLLSYGAVIEVQNKASLTPLLLAIQKRSKQTVEFLLTKNANANAFNESKCTALML 211
Query: 736 ASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDTQS 795
A G + V +LL Q D D G +A A + + L H+ + Q+
Sbjct: 212 AICEGSSEIVGMLLQQ-NVDVFAEDIHGITAERYAAACGVNYIHQQLLEHIRKLPKNPQN 270
Query: 796 ESPPGSQTATPGE 808
+P G+ T TP E
Sbjct: 271 TNPEGTSTGTPDE 283
Score = 52.4 bits (124), Expect = 2e-06
Identities = 51/196 (26%), Positives = 86/196 (43%), Gaps = 14/196 (7%)
Query: 591 RSQAEPVARMLEGVRRLGPELLAHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEV 650
R Q + + +M G + + +N D TALH++ +G+ + + L+D C++
Sbjct: 48 RGQVQKLEKMTVGKKPVN-------LNKRDMKKRTALHWACVNGHAEVVTFLVDR-KCQL 99
Query: 651 NRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQD 710
N + G + LM A Q E + + D+N G TAL A+
Sbjct: 100 NVLDGEGRTPLMKAL-----QCEREACANILIDAGADLNY-VDVYGNTALHYAVYSENLL 153
Query: 711 MVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIA 770
MVATLL+ GA + Q+ T L+ A + TV LLT+ A +++ T+ +
Sbjct: 154 MVATLLSYGAVIEVQNKASLTPLLLAIQKRSKQTVEFLLTKNANANAFNESKCTALMLAI 213
Query: 771 LEAEQDEVAALLHAHL 786
E + V LL ++
Sbjct: 214 CEGSSEIVGMLLQQNV 229
>gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo
sapiens]
Length = 917
Score = 63.2 bits (152), Expect = 1e-09
Identities = 61/211 (28%), Positives = 99/211 (46%), Gaps = 14/211 (6%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
+NL D TAL +V AS+LL+ GA N ++ G +AL A + E+
Sbjct: 98 LNLTDSENRTALIKAVQCQEEVCASILLEHGA-NPNVRDMYGNTALHYAI------DNEN 150
Query: 676 MAVVQRLFCMG-DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALM 734
+++ ++L G D+ A+ SQ G T+L+LA++ ++ MVA LL D+ A D G TAL+
Sbjct: 151 ISMARKLLAYGADIEAR-SQDGHTSLLLAVNRKKEQMVAFLLKKKPDLTAIDNFGRTALI 209
Query: 735 CASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDTQ 794
A+ G V LL Q D D G +A A+ ++ + ++ + ++ + +
Sbjct: 210 LAARNGSTSVVYQLL-QHNIDVFCQDISGWTAEDYAVASKFQAIRGMISEYKANKRCKSL 268
Query: 795 SESPPGSQTATPGEGEC----GDNGENPQVQ 821
S EGE G PQV+
Sbjct: 269 QNSNSEQDLEMTSEGEQERLEGCESSQPQVE 299
Score = 51.6 bits (122), Expect = 3e-06
Identities = 36/129 (27%), Positives = 64/129 (49%), Gaps = 14/129 (10%)
Query: 670 RQEEEDMAVVQRLFCMGDVNA-------------KASQTGQTALMLAISHGRQDMVATLL 716
R ++D+ ++ + GDVN + +TAL+LA +HGR +VA L+
Sbjct: 33 RVRQKDLGMIHKAAIAGDVNKVMESILLRLNDLNDRDKKNRTALLLACAHGRPGVVADLV 92
Query: 717 ACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQD 776
A +N D++ TAL+ A + + + +L + G +P + D G +AL A++ E
Sbjct: 93 ARKCQLNLTDSENRTALIKAVQC-QEEVCASILLEHGANPNVRDMYGNTALHYAIDNENI 151
Query: 777 EVAALLHAH 785
+A L A+
Sbjct: 152 SMARKLLAY 160
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 63.2 bits (152), Expect = 1e-09
Identities = 61/187 (32%), Positives = 87/187 (46%), Gaps = 19/187 (10%)
Query: 615 VVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALML----------- 663
VVN+AD T LH + + G I LLL GA + ++NR G + L L
Sbjct: 584 VVNVADLWKFTPLHEAAAKGKYEICKLLLQHGA-DPTKKNRDGNTPLDLVKDGDTDIQDL 642
Query: 664 ----AALTSVRQEEEDMAVVQRLFCMGDVNAKASQ-TGQTALMLAISHGRQDMVATLLAC 718
AAL ++ +A V++L +VN + +Q T L LA + ++ LL
Sbjct: 643 LRGDAALLDAAKKG-CLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQH 701
Query: 719 GADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEV 778
GADVNAQD G L A+ YG +D LL+ C A D + L A + + ++
Sbjct: 702 GADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA-TDKWAFTPLHEAAQKGRTQL 760
Query: 779 AALLHAH 785
ALL AH
Sbjct: 761 CALLLAH 767
Score = 51.6 bits (122), Expect = 3e-06
Identities = 45/155 (29%), Positives = 67/155 (43%), Gaps = 22/155 (14%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEE- 674
VN D G T+LH + G+L LLL G C+ N + G++AL + + +E
Sbjct: 426 VNALDNLGQTSLHRAAYCGHLQTCRLLLSYG-CDPNIISLQGFTALQMGNENVQQLLQEG 484
Query: 675 -------------------DMAVVQRLFCMGDVNAKASQTGQ-TALMLAISHGRQDMVAT 714
D+ V++L + VN + + Q T L A + R +V
Sbjct: 485 ISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544
Query: 715 LLACGADVNAQDADGATALMCASEYGRLDTVRLLL 749
LL GADV+A+D G L A YG + LL+
Sbjct: 545 LLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLV 579
Score = 48.5 bits (114), Expect = 2e-05
Identities = 60/232 (25%), Positives = 89/232 (38%), Gaps = 57/232 (24%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQE--- 672
VN D T LH + S + + SLLL GA + N SA+ LA +++
Sbjct: 270 VNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA-DPTLLNCHNKSAIDLAPTPQLKERLAY 328
Query: 673 ------------EEDMAVVQRLFCMGDVNAKASQTGQTALMLAISH-------------- 706
E D+ +++ + VN K QT +TAL A +
Sbjct: 329 EFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLR 388
Query: 707 ----------------------GRQDMVATLLACGADVNAQDADGATALMCASEYGRLDT 744
D+V ++ A VNA D G T+L A+ G L T
Sbjct: 389 KGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQT 448
Query: 745 VRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDTQSE 796
RLLL+ GCDP I+ +G +AL + + V LL +S G + +
Sbjct: 449 CRLLLSY-GCDPNIISLQGFTALQMG----NENVQQLLQEGISLGNSEADRQ 495
Score = 48.1 bits (113), Expect = 3e-05
Identities = 58/185 (31%), Positives = 79/185 (42%), Gaps = 25/185 (13%)
Query: 617 NLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLA------------ 664
N D T LH + G + + +LL GA E +N G +AL LA
Sbjct: 118 NARDNWNYTPLHEAAIKGKIDVCIVLLQHGA-EPTIRNTDGRTALDLADPSAKAVLTGEY 176
Query: 665 ----ALTSVRQ--EEEDMAVVQRLFCMGDVNAKASQTGQ-TALMLAISHGRQDMVATLLA 717
L S R EE+ MA++ L +VN AS + T L LA + R +V LL
Sbjct: 177 KKDELLESARSGNEEKMMALLTPL----NVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQ 232
Query: 718 CGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDE 777
GADV+A+D L A YG + LL+ C A +D + L A + E
Sbjct: 233 HGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNA-MDLWQFTPLHEAASKNRVE 291
Query: 778 VAALL 782
V +LL
Sbjct: 292 VCSLL 296
Score = 46.6 bits (109), Expect = 9e-05
Identities = 38/112 (33%), Positives = 54/112 (48%), Gaps = 2/112 (1%)
Query: 675 DMAVVQRLFCMGDVNAK-ASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATAL 733
D+ V+RL VN++ + T L A GR+D+V LL GA+V A+D G L
Sbjct: 36 DVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPL 95
Query: 734 MCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAH 785
A +G + V LLL + G DP DN + L A + +V +L H
Sbjct: 96 HNACSFGHAEVVNLLL-RHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 146
Score = 45.1 bits (105), Expect = 3e-04
Identities = 47/137 (34%), Positives = 63/137 (45%), Gaps = 13/137 (9%)
Query: 616 VNLADGNG--NTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEE 673
VN D G +T LH + + NL +A LL GA +VN Q++ G L AA S +
Sbjct: 670 VNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGA-DVNAQDKGGLIPLHNAA--SYGHVD 726
Query: 674 EDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATAL 733
+++ C VNA + T L A GR + A LLA GAD ++ +G T L
Sbjct: 727 VAALLIKYNAC---VNA-TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL 782
Query: 734 MCASEYGRLDTVRLLLT 750
S D V LLT
Sbjct: 783 DLVS----ADDVSALLT 795
Score = 43.9 bits (102), Expect = 6e-04
Identities = 53/189 (28%), Positives = 78/189 (41%), Gaps = 25/189 (13%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
V D G LH + S G+ + +LLL GA + N ++ Y+ L AA+ + + D
Sbjct: 84 VQARDDGGLIPLHNACSFGHAEVVNLLLRHGA-DPNARDNWNYTPLHEAAI----KGKID 138
Query: 676 MAVV---------------QRLFCMGDVNAKASQTGQ----TALMLAISHGRQDMVATLL 716
+ +V + + D +AKA TG+ L A S + M+A L
Sbjct: 139 VCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLT 198
Query: 717 ACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQD 776
+ +A D +T L A+ Y R+ V+LLL Q G D D L A
Sbjct: 199 PLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLL-QHGADVHAKDKGDLVPLHNACSYGHY 257
Query: 777 EVAALLHAH 785
EV LL H
Sbjct: 258 EVTELLVKH 266
Score = 38.1 bits (87), Expect = 0.033
Identities = 40/152 (26%), Positives = 59/152 (38%), Gaps = 41/152 (26%)
Query: 619 ADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAV 678
+DG +T LH + + + I LLL GA
Sbjct: 207 SDGRKSTPLHLAAGYNRVKIVQLLLQHGA------------------------------- 235
Query: 679 VQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASE 738
DV+AK + L A S+G ++ L+ GA VNA D T L A+
Sbjct: 236 --------DVHAK-DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAAS 286
Query: 739 YGRLDTVRLLLTQPGCDPAILDNEGTSALAIA 770
R++ LLL+ G DP +L+ SA+ +A
Sbjct: 287 KNRVEVCSLLLSY-GADPTLLNCHNKSAIDLA 317
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 63.2 bits (152), Expect = 1e-09
Identities = 90/320 (28%), Positives = 122/320 (38%), Gaps = 66/320 (20%)
Query: 480 SSSEDASDSDGDSENGGAEPPGSSSGSGDDSGGGSDSGTP-------------------- 519
SSSE +SDSD GG G G GGG+ S
Sbjct: 84 SSSESSSDSDNSGGGGGG-------GGGGGGGGGTSSNNSEEEEDDDDEEEEVSEVESFI 136
Query: 520 --------------------GPPSGGDIR--DPEPEAEAEPQQVAQGRCELSPRLREACV 557
G G D+R DPE +A E A G +LS +A
Sbjct: 137 LDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFA 196
Query: 558 --ALQRQLSRPRGVASDGGAVRLVAQEWFRVS----SQRRSQAEPVARM-LEGVRRLGPE 610
+ R+L+ A D A L + S RS AE + + VR+L E
Sbjct: 197 DPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIE 256
Query: 611 LLAHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVR 670
VN G + L + S G +A +LL A +R + + LM AA
Sbjct: 257 --GRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA----- 309
Query: 671 QEEEDMAVVQRLFC-MGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADG 729
+ +V+ L DVNA++S TG TAL A + G D+V LL GA + + +G
Sbjct: 310 -NGGHVKIVKLLLAHKADVNAQSS-TGNTALTYACAGGYVDVVKVLLESGASIEDHNENG 367
Query: 730 ATALMCASEYGRLDTVRLLL 749
T LM A G ++ RLLL
Sbjct: 368 HTPLMEAGSAGHVEVARLLL 387
Score = 62.0 bits (149), Expect = 2e-09
Identities = 62/203 (30%), Positives = 92/203 (45%), Gaps = 11/203 (5%)
Query: 611 LLAHV--VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTS 668
LLAH VN GNTAL Y+ + G + + +LL++GA + N G++ LM A
Sbjct: 320 LLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGA-SIEDHNENGHTPLMEAGSAG 378
Query: 669 VRQEEEDMAVVQRLFCMG-DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDA 727
+ V + L G +N +++ ++AL LA G +MV LL GAD +
Sbjct: 379 ------HVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTD 432
Query: 728 DGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLS 787
+ TALM A G ++ RLLL G + + S L +A E+AALL +
Sbjct: 433 EMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 491
Query: 788 SGQPDTQSESPPGSQTATPGEGE 810
S + P + A G E
Sbjct: 492 SLEEVNDEGYTPLMEAAREGHEE 514
Score = 59.3 bits (142), Expect = 1e-08
Identities = 70/219 (31%), Positives = 105/219 (47%), Gaps = 19/219 (8%)
Query: 574 GAVRLVAQEWFRVSSQ-RRSQAEPVARMLEGVRRLGPELL-AHVVNLADGNGN--TALHY 629
G V ++ + +Q R++ P++ G R+ ELL A N N + T L
Sbjct: 1130 GVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 1189
Query: 630 SVSHGNLAIASLLLDTGACEVNRQ--NRAGYSALMLAALTSVRQEEEDMAVVQRLFCMG- 686
+ S G + I +LL+ GA E+N + ++ G S LMLAA+ A V+ L MG
Sbjct: 1190 AASGGYVNIIKILLNAGA-EINSRTGSKLGISPLMLAAMNG------HTAAVKLLLDMGS 1242
Query: 687 DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVR 746
D+NA+ TAL LA GR ++V+ LL A+V + G T LM A+ G + R
Sbjct: 1243 DINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1302
Query: 747 LLLTQPGCD---PAILDNEGTSALAIALEAEQDEVAALL 782
+LL + G D P + + T AL IA + + LL
Sbjct: 1303 VLLDK-GADVNAPPVPSSRDT-ALTIAADKGHYKFCELL 1339
Score = 58.5 bits (140), Expect = 2e-08
Identities = 60/227 (26%), Positives = 93/227 (40%), Gaps = 17/227 (7%)
Query: 566 PRGVASDGGAVRLVAQEWFRVSSQRRSQAEPVARMLEGVRRLGPELLAHVVNLA------ 619
P +A+ GG V L A R +S E ++E R E++A ++
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ 529
Query: 620 -DGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAV 678
+ TAL + G L +A L+ GA G S ++ A +E + +
Sbjct: 530 TEETQETALTLACCGGFLEVADFLIKAGA-----DIELGCSTPLMEAA-----QEGHLEL 579
Query: 679 VQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASE 738
V+ L G + TG TAL A +G D+ LL GAD+ + G T LM A+
Sbjct: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
Query: 739 YGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAH 785
G + TV+ L+++ N + L++A V LL AH
Sbjct: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAH 686
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/154 (33%), Positives = 73/154 (47%), Gaps = 10/154 (6%)
Query: 602 EGVRRLGPELLAHVVNL--ADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYS 659
EG L LLA N+ G+TAL Y+ +G+ +A +LL GA ++ ++ G +
Sbjct: 574 EGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGA-DLEHESEGGRT 632
Query: 660 ALMLAALTSVRQEEEDMAVVQRLFCMG-DVNAKASQTGQTALMLAISHGRQDMVATLLAC 718
LM AA + VQ L G +VN + T L LA + G +V LLA
Sbjct: 633 PLMKAARAG------HVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAH 686
Query: 719 GADVNAQDADGATALMCASEYGRLDTVRLLLTQP 752
GAD + DG+T L+ A++ G V LL P
Sbjct: 687 GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720
Score = 58.5 bits (140), Expect = 2e-08
Identities = 41/131 (31%), Positives = 72/131 (54%), Gaps = 8/131 (6%)
Query: 620 DGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVV 679
+ N +TAL + + G+ + LL+ GA + +++ G++ L+LAA + VV
Sbjct: 1080 ESNHDTALTLACAGGHEELVQTLLERGA-SIEHRDKKGFTPLILAATAG------HVGVV 1132
Query: 680 QRLFCMG-DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASE 738
+ L G D+ A++ +T T L LA S GRQ++V LLA GA+ ++ T L A+
Sbjct: 1133 EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 1192
Query: 739 YGRLDTVRLLL 749
G ++ +++LL
Sbjct: 1193 GGYVNIIKILL 1203
Score = 53.5 bits (127), Expect = 8e-07
Identities = 36/121 (29%), Positives = 59/121 (48%)
Query: 687 DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVR 746
D++A+ TAL LA + G +++V TLL GA + +D G T L+ A+ G + V
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
Query: 747 LLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDTQSESPPGSQTATP 806
+LL A + + L++A + EV LL A ++ + S+ P S A+
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193
Query: 807 G 807
G
Sbjct: 1194 G 1194
Score = 46.2 bits (108), Expect = 1e-04
Identities = 54/181 (29%), Positives = 73/181 (40%), Gaps = 13/181 (7%)
Query: 624 NTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLF 683
+T L + G+L + LL GA V+ G +AL A E V L
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGA-NVHATTATGDTALTYAC------ENGHTDVADVLL 617
Query: 684 CMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADG-ATALMCASEYGRL 742
G S+ G+T LM A G V L++ GA+VN A+ T L A G L
Sbjct: 618 QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHL 677
Query: 743 DTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAH----LSSGQPDTQSESP 798
V LLL G DP +G++ L A + V L + LS+ PD +P
Sbjct: 678 AVVELLLAH-GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTP 736
Query: 799 P 799
P
Sbjct: 737 P 737
Score = 44.3 bits (103), Expect = 5e-04
Identities = 51/182 (28%), Positives = 72/182 (39%), Gaps = 32/182 (17%)
Query: 622 NGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQ---------- 671
N NTAL + G + SLLLD A V + + G + LM AA +
Sbjct: 1251 NRNTALTLACFQGRTEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1309
Query: 672 --------EEEDMAVV------QRLFCMGDVNAKA-----SQTGQTALMLAISHGRQDMV 712
D A+ FC + A ++ G T L LA + G D+V
Sbjct: 1310 DVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVV 1369
Query: 713 ATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALE 772
L+ GADV+A D T LM A G + VR L+ + P+ D+E +A +
Sbjct: 1370 QLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPS--DSECMRYIATITD 1427
Query: 773 AE 774
E
Sbjct: 1428 KE 1429
Score = 42.4 bits (98), Expect = 0.002
Identities = 53/188 (28%), Positives = 77/188 (40%), Gaps = 27/188 (14%)
Query: 622 NGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAA----LTSVR------- 670
NG+T L + S G++ +A LLL+ GA N SAL LA L VR
Sbjct: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGA 425
Query: 671 ---QEEEDMAVVQRLFCMG----------DVNAKASQTG---QTALMLAISHGRQDMVAT 714
+ ++M CM D A+ + ++ L LA G ++ A
Sbjct: 426 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 485
Query: 715 LLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAE 774
L+ GA + + +G T LM A+ G + V LLL Q A + +AL +A
Sbjct: 486 LIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGG 545
Query: 775 QDEVAALL 782
EVA L
Sbjct: 546 FLEVADFL 553
Score = 34.3 bits (77), Expect = 0.48
Identities = 26/88 (29%), Positives = 38/88 (43%), Gaps = 2/88 (2%)
Query: 455 TPGAQPSSGPKSLQF-VGVLNGEYESSSSEDASDSDGDSENGGAEPPGSSSGSGDDSGGG 513
+P AQP ++ G + +SSSE + S E PP SSS SG S
Sbjct: 2047 SPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHS 2106
Query: 514 SDSGTPGPPSGGDIRDPEPEAEAEPQQV 541
+ PG S + R P +++ P +V
Sbjct: 2107 NQQQPPGSVS-QEPRPPLQQSQVPPPEV 2133
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 63.2 bits (152), Expect = 1e-09
Identities = 90/320 (28%), Positives = 122/320 (38%), Gaps = 66/320 (20%)
Query: 480 SSSEDASDSDGDSENGGAEPPGSSSGSGDDSGGGSDSGTP-------------------- 519
SSSE +SDSD GG G G GGG+ S
Sbjct: 84 SSSESSSDSDNSGGGGGG-------GGGGGGGGGTSSNNSEEEEDDDDEEEEVSEVESFI 136
Query: 520 --------------------GPPSGGDIR--DPEPEAEAEPQQVAQGRCELSPRLREACV 557
G G D+R DPE +A E A G +LS +A
Sbjct: 137 LDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFA 196
Query: 558 --ALQRQLSRPRGVASDGGAVRLVAQEWFRVS----SQRRSQAEPVARM-LEGVRRLGPE 610
+ R+L+ A D A L + S RS AE + + VR+L E
Sbjct: 197 DPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIE 256
Query: 611 LLAHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVR 670
VN G + L + S G +A +LL A +R + + LM AA
Sbjct: 257 --GRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA----- 309
Query: 671 QEEEDMAVVQRLFC-MGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADG 729
+ +V+ L DVNA++S TG TAL A + G D+V LL GA + + +G
Sbjct: 310 -NGGHVKIVKLLLAHKADVNAQSS-TGNTALTYACAGGYVDVVKVLLESGASIEDHNENG 367
Query: 730 ATALMCASEYGRLDTVRLLL 749
T LM A G ++ RLLL
Sbjct: 368 HTPLMEAGSAGHVEVARLLL 387
Score = 62.0 bits (149), Expect = 2e-09
Identities = 62/203 (30%), Positives = 92/203 (45%), Gaps = 11/203 (5%)
Query: 611 LLAHV--VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTS 668
LLAH VN GNTAL Y+ + G + + +LL++GA + N G++ LM A
Sbjct: 320 LLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGA-SIEDHNENGHTPLMEAGSAG 378
Query: 669 VRQEEEDMAVVQRLFCMG-DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDA 727
+ V + L G +N +++ ++AL LA G +MV LL GAD +
Sbjct: 379 ------HVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTD 432
Query: 728 DGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLS 787
+ TALM A G ++ RLLL G + + S L +A E+AALL +
Sbjct: 433 EMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 491
Query: 788 SGQPDTQSESPPGSQTATPGEGE 810
S + P + A G E
Sbjct: 492 SLEEVNDEGYTPLMEAAREGHEE 514
Score = 59.3 bits (142), Expect = 1e-08
Identities = 70/219 (31%), Positives = 105/219 (47%), Gaps = 19/219 (8%)
Query: 574 GAVRLVAQEWFRVSSQ-RRSQAEPVARMLEGVRRLGPELL-AHVVNLADGNGN--TALHY 629
G V ++ + +Q R++ P++ G R+ ELL A N N + T L
Sbjct: 879 GVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 938
Query: 630 SVSHGNLAIASLLLDTGACEVNRQ--NRAGYSALMLAALTSVRQEEEDMAVVQRLFCMG- 686
+ S G + I +LL+ GA E+N + ++ G S LMLAA+ A V+ L MG
Sbjct: 939 AASGGYVNIIKILLNAGA-EINSRTGSKLGISPLMLAAMNG------HTAAVKLLLDMGS 991
Query: 687 DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVR 746
D+NA+ TAL LA GR ++V+ LL A+V + G T LM A+ G + R
Sbjct: 992 DINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1051
Query: 747 LLLTQPGCD---PAILDNEGTSALAIALEAEQDEVAALL 782
+LL + G D P + + T AL IA + + LL
Sbjct: 1052 VLLDK-GADVNAPPVPSSRDT-ALTIAADKGHYKFCELL 1088
Score = 58.5 bits (140), Expect = 2e-08
Identities = 60/227 (26%), Positives = 93/227 (40%), Gaps = 17/227 (7%)
Query: 566 PRGVASDGGAVRLVAQEWFRVSSQRRSQAEPVARMLEGVRRLGPELLAHVVNLA------ 619
P +A+ GG V L A R +S E ++E R E++A ++
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ 529
Query: 620 -DGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAV 678
+ TAL + G L +A L+ GA G S ++ A +E + +
Sbjct: 530 TEETQETALTLACCGGFLEVADFLIKAGA-----DIELGCSTPLMEAA-----QEGHLEL 579
Query: 679 VQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASE 738
V+ L G + TG TAL A +G D+ LL GAD+ + G T LM A+
Sbjct: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
Query: 739 YGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAH 785
G + TV+ L+++ N + L++A V LL AH
Sbjct: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAH 686
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/154 (33%), Positives = 73/154 (47%), Gaps = 10/154 (6%)
Query: 602 EGVRRLGPELLAHVVNL--ADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYS 659
EG L LLA N+ G+TAL Y+ +G+ +A +LL GA ++ ++ G +
Sbjct: 574 EGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGA-DLEHESEGGRT 632
Query: 660 ALMLAALTSVRQEEEDMAVVQRLFCMG-DVNAKASQTGQTALMLAISHGRQDMVATLLAC 718
LM AA + VQ L G +VN + T L LA + G +V LLA
Sbjct: 633 PLMKAARAG------HVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAH 686
Query: 719 GADVNAQDADGATALMCASEYGRLDTVRLLLTQP 752
GAD + DG+T L+ A++ G V LL P
Sbjct: 687 GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720
Score = 58.5 bits (140), Expect = 2e-08
Identities = 41/131 (31%), Positives = 72/131 (54%), Gaps = 8/131 (6%)
Query: 620 DGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVV 679
+ N +TAL + + G+ + LL+ GA + +++ G++ L+LAA + VV
Sbjct: 829 ESNHDTALTLACAGGHEELVQTLLERGA-SIEHRDKKGFTPLILAATAG------HVGVV 881
Query: 680 QRLFCMG-DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASE 738
+ L G D+ A++ +T T L LA S GRQ++V LLA GA+ ++ T L A+
Sbjct: 882 EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 941
Query: 739 YGRLDTVRLLL 749
G ++ +++LL
Sbjct: 942 GGYVNIIKILL 952
Score = 53.5 bits (127), Expect = 8e-07
Identities = 36/121 (29%), Positives = 59/121 (48%)
Query: 687 DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVR 746
D++A+ TAL LA + G +++V TLL GA + +D G T L+ A+ G + V
Sbjct: 823 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882
Query: 747 LLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDTQSESPPGSQTATP 806
+LL A + + L++A + EV LL A ++ + S+ P S A+
Sbjct: 883 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 942
Query: 807 G 807
G
Sbjct: 943 G 943
Score = 46.2 bits (108), Expect = 1e-04
Identities = 54/181 (29%), Positives = 73/181 (40%), Gaps = 13/181 (7%)
Query: 624 NTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLF 683
+T L + G+L + LL GA V+ G +AL A E V L
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGA-NVHATTATGDTALTYAC------ENGHTDVADVLL 617
Query: 684 CMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADG-ATALMCASEYGRL 742
G S+ G+T LM A G V L++ GA+VN A+ T L A G L
Sbjct: 618 QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHL 677
Query: 743 DTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAH----LSSGQPDTQSESP 798
V LLL G DP +G++ L A + V L + LS+ PD +P
Sbjct: 678 AVVELLLAH-GADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTP 736
Query: 799 P 799
P
Sbjct: 737 P 737
Score = 44.3 bits (103), Expect = 5e-04
Identities = 51/182 (28%), Positives = 72/182 (39%), Gaps = 32/182 (17%)
Query: 622 NGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQ---------- 671
N NTAL + G + SLLLD A V + + G + LM AA +
Sbjct: 1000 NRNTALTLACFQGRTEVVSLLLDRKA-NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1058
Query: 672 --------EEEDMAVV------QRLFCMGDVNAKA-----SQTGQTALMLAISHGRQDMV 712
D A+ FC + A ++ G T L LA + G D+V
Sbjct: 1059 DVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVV 1118
Query: 713 ATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALE 772
L+ GADV+A D T LM A G + VR L+ + P+ D+E +A +
Sbjct: 1119 QLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPS--DSECMRYIATITD 1176
Query: 773 AE 774
E
Sbjct: 1177 KE 1178
Score = 42.4 bits (98), Expect = 0.002
Identities = 53/188 (28%), Positives = 77/188 (40%), Gaps = 27/188 (14%)
Query: 622 NGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAA----LTSVR------- 670
NG+T L + S G++ +A LLL+ GA N SAL LA L VR
Sbjct: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGA 425
Query: 671 ---QEEEDMAVVQRLFCMG----------DVNAKASQTG---QTALMLAISHGRQDMVAT 714
+ ++M CM D A+ + ++ L LA G ++ A
Sbjct: 426 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 485
Query: 715 LLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAE 774
L+ GA + + +G T LM A+ G + V LLL Q A + +AL +A
Sbjct: 486 LIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGG 545
Query: 775 QDEVAALL 782
EVA L
Sbjct: 546 FLEVADFL 553
Score = 34.3 bits (77), Expect = 0.48
Identities = 26/88 (29%), Positives = 38/88 (43%), Gaps = 2/88 (2%)
Query: 455 TPGAQPSSGPKSLQF-VGVLNGEYESSSSEDASDSDGDSENGGAEPPGSSSGSGDDSGGG 513
+P AQP ++ G + +SSSE + S E PP SSS SG S
Sbjct: 1796 SPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHS 1855
Query: 514 SDSGTPGPPSGGDIRDPEPEAEAEPQQV 541
+ PG S + R P +++ P +V
Sbjct: 1856 NQQQPPGSVS-QEPRPPLQQSQVPPPEV 1882
>gi|10863929 ribonuclease L [Homo sapiens]
Length = 741
Score = 62.8 bits (151), Expect = 1e-09
Identities = 70/229 (30%), Positives = 104/229 (45%), Gaps = 29/229 (12%)
Query: 581 QEWFRVSSQRRSQAEPVARMLEGVRRLGPELLAHV------VNLADGNGN-TALHYSVSH 633
QE SS RR+ E +++ V+ +L+ + VN + G T LH +V
Sbjct: 10 QEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQM 69
Query: 634 GNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCM--GDVNAK 691
I LLL GA V R+ ++ A SV+ + +LF DVN +
Sbjct: 70 SREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVK--------LLKLFLSKGADVN-E 120
Query: 692 ASQTGQTALMLAISHGRQDMVATLLACGADVNA-----QDAD-----GATALMCASEYGR 741
G TA M A +G+ + L GA+VN +D + GATALM A+E G
Sbjct: 121 CDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGH 180
Query: 742 LDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQD-EVAALLHAHLSSG 789
++ +++LL + G D DN G +AL AL + D +V A+ H L G
Sbjct: 181 VEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHG 229
Score = 50.4 bits (119), Expect = 6e-06
Identities = 44/133 (33%), Positives = 69/133 (51%), Gaps = 6/133 (4%)
Query: 623 GNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRL 682
G TAL + G++ + +LLD +VN + G +AL+ A L+S + E A+ L
Sbjct: 168 GATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVE--AITHLL 225
Query: 683 FCMG-DVNAKASQTGQTALMLAISHGRQDMVATLLACG-ADVNAQDADGATALMCASEYG 740
G DVN + + G+T L+LA+ +V LL ++N D+DG TAL+ A E
Sbjct: 226 LDHGADVNVRGER-GKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVEL- 283
Query: 741 RLDTVRLLLTQPG 753
+L + LL + G
Sbjct: 284 KLKKIAELLCKRG 296
Score = 30.0 bits (66), Expect = 9.1
Identities = 24/96 (25%), Positives = 45/96 (46%), Gaps = 1/96 (1%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
VN+ G T L +V +L + LL+ E+N + G +AL+LA +++ E
Sbjct: 232 VNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAEL 291
Query: 676 MAVVQRLFCMGDVNAKASQTGQTALM-LAISHGRQD 710
+ GD+ A + +L+ + +SHG ++
Sbjct: 292 LCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKE 327
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 62.4 bits (150), Expect = 2e-09
Identities = 50/166 (30%), Positives = 76/166 (45%), Gaps = 12/166 (7%)
Query: 644 DTGACEVNRQNRAGYSALMLA-----ALTSVRQEEEDM-----AVVQRLFCMG-DVNAKA 692
D +VN + G++ LMLA AL + EE++ +++ L C G + A+
Sbjct: 1776 DADGMDVNVRGPDGFTPLMLASFCGGALEPMPTEEDEADDTSASIISDLICQGAQLGART 1835
Query: 693 SQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQP 752
+TG+TAL LA + R D LL GAD NAQD G T L A ++L+
Sbjct: 1836 DRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNR 1895
Query: 753 GCDPAILDNEGTSALAIALE-AEQDEVAALLHAHLSSGQPDTQSES 797
D +G++AL +A A + V L+ +H D +S
Sbjct: 1896 STDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKS 1941
Score = 59.3 bits (142), Expect = 1e-08
Identities = 53/169 (31%), Positives = 83/169 (49%), Gaps = 7/169 (4%)
Query: 620 DGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVV 679
D G TALH + + A LLD GA + N Q+ +G + L A+T+ Q + +
Sbjct: 1836 DRTGETALHLAARYARADAAKRLLDAGA-DTNAQDHSGRTPLH-TAVTADAQGVFQILIR 1893
Query: 680 QRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEY 739
R D++A+ + G TAL+LA + MV L+A ADVNA D G +AL A+
Sbjct: 1894 NR---STDLDARMAD-GSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAV 1949
Query: 740 GRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSS 788
++ L L + G + + D++ + L +A E A LL H ++
Sbjct: 1950 NNVEAT-LALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFAN 1997
Score = 50.1 bits (118), Expect = 8e-06
Identities = 50/190 (26%), Positives = 84/190 (44%), Gaps = 14/190 (7%)
Query: 617 NLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDM 676
N D +G T LH +V+ + +L+ + +++ + G +AL+LAA +V E++
Sbjct: 1866 NAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEEL 1925
Query: 677 AVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCA 736
+ DVNA + G++AL A + + LL GA+ + QD+ T L A
Sbjct: 1926 -----IASHADVNA-VDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLA 1979
Query: 737 SEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDTQSE 796
+ G + +LLL + I D+ +A E ++ LL QP +
Sbjct: 1980 AREGSYEAAKLLLDH-FANREITDHLDRLPRDVAQERLHQDIVRLL------DQP-SGPR 2031
Query: 797 SPPGSQTATP 806
SPPG P
Sbjct: 2032 SPPGPHGLGP 2041
>gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens]
Length = 917
Score = 62.4 bits (150), Expect = 2e-09
Identities = 60/211 (28%), Positives = 99/211 (46%), Gaps = 14/211 (6%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
+NL D TAL +V AS+LL+ GA N ++ G +AL A + E+
Sbjct: 98 LNLTDSENRTALIKAVQCQEEVCASILLEHGA-NPNVRDMYGNTALHYAI------DNEN 150
Query: 676 MAVVQRLFCMG-DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALM 734
+++ ++L G D+ A+ SQ G T+L+LA++ ++ MV+ LL D+ A D G TAL+
Sbjct: 151 ISMARKLLAYGADIEAR-SQDGHTSLLLAVNRKKEQMVSFLLKKKPDLTAIDNFGRTALI 209
Query: 735 CASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDTQ 794
A+ G V LL Q D D G +A A+ ++ + ++ + ++ + +
Sbjct: 210 LAARNGSTSVVYQLL-QHNIDVFCQDISGWTAEDYAVASKFQAIRGMISEYKANKRRKSL 268
Query: 795 SESPPGSQTATPGEGEC----GDNGENPQVQ 821
S EGE G PQV+
Sbjct: 269 QNSNSEQDLEMTSEGEQERLEGCESSQPQVE 299
Score = 51.6 bits (122), Expect = 3e-06
Identities = 36/129 (27%), Positives = 64/129 (49%), Gaps = 14/129 (10%)
Query: 670 RQEEEDMAVVQRLFCMGDVNA-------------KASQTGQTALMLAISHGRQDMVATLL 716
R ++D+ ++ + GDVN + +TAL+LA +HGR +VA L+
Sbjct: 33 RVRQKDLGMIHKAAIAGDVNKVMESILLRLNDLNDRDKKNRTALLLACAHGRPGVVADLV 92
Query: 717 ACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQD 776
A +N D++ TAL+ A + + + +L + G +P + D G +AL A++ E
Sbjct: 93 ARKCQLNLTDSENRTALIKAVQC-QEEVCASILLEHGANPNVRDMYGNTALHYAIDNENI 151
Query: 777 EVAALLHAH 785
+A L A+
Sbjct: 152 SMARKLLAY 160
>gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo
sapiens]
Length = 917
Score = 62.4 bits (150), Expect = 2e-09
Identities = 60/211 (28%), Positives = 99/211 (46%), Gaps = 14/211 (6%)
Query: 616 VNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEED 675
+NL D TAL +V AS+LL+ GA N ++ G +AL A + E+
Sbjct: 98 LNLTDSENRTALIKAVQCQEEVCASILLEHGA-NPNVRDMYGNTALHYAI------DNEN 150
Query: 676 MAVVQRLFCMG-DVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALM 734
+++ ++L G D+ A+ SQ G T+L+LA++ ++ MV+ LL D+ A D G TAL+
Sbjct: 151 ISMARKLLAYGADIEAR-SQDGHTSLLLAVNRKKEQMVSFLLKKKPDLTAIDNFGRTALI 209
Query: 735 CASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDTQ 794
A+ G V LL Q D D G +A A+ ++ + ++ + ++ + +
Sbjct: 210 LAARNGSTSVVYQLL-QHNIDVFCQDISGWTAEDYAVASKFQAIRGMISEYKANKRRKSL 268
Query: 795 SESPPGSQTATPGEGEC----GDNGENPQVQ 821
S EGE G PQV+
Sbjct: 269 QNSNSEQDLEMTSEGEQERLEGCESSQPQVE 299
Score = 51.6 bits (122), Expect = 3e-06
Identities = 36/129 (27%), Positives = 64/129 (49%), Gaps = 14/129 (10%)
Query: 670 RQEEEDMAVVQRLFCMGDVNA-------------KASQTGQTALMLAISHGRQDMVATLL 716
R ++D+ ++ + GDVN + +TAL+LA +HGR +VA L+
Sbjct: 33 RVRQKDLGMIHKAAIAGDVNKVMESILLRLNDLNDRDKKNRTALLLACAHGRPGVVADLV 92
Query: 717 ACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQD 776
A +N D++ TAL+ A + + + +L + G +P + D G +AL A++ E
Sbjct: 93 ARKCQLNLTDSENRTALIKAVQC-QEEVCASILLEHGANPNVRDMYGNTALHYAIDNENI 151
Query: 777 EVAALLHAH 785
+A L A+
Sbjct: 152 SMARKLLAY 160
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,540,655
Number of Sequences: 37866
Number of extensions: 2212570
Number of successful extensions: 23212
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 488
Number of HSP's successfully gapped in prelim test: 1267
Number of HSP's that attempted gapping in prelim test: 14428
Number of HSP's gapped (non-prelim): 7737
length of query: 821
length of database: 18,247,518
effective HSP length: 111
effective length of query: 710
effective length of database: 14,044,392
effective search space: 9971518320
effective search space used: 9971518320
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.