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Search of human proteins with 157074214
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157074214 potassium channel, subfamily U, member 1 [Homo
sapiens]
(1149 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157074214 potassium channel, subfamily U, member 1 [Homo sapi... 2305 0.0
gi|26638650 large conductance calcium-activated potassium channe... 890 0.0
gi|62388890 large conductance calcium-activated potassium channe... 889 0.0
gi|238624130 large conductance calcium-activated potassium chann... 878 0.0
gi|238624132 large conductance calcium-activated potassium chann... 871 0.0
gi|41349443 potassium channel, subfamily T, member 2 [Homo sapiens] 142 2e-33
gi|240255505 potassium channel, subfamily T, member 1 [Homo sapi... 112 2e-24
gi|4826784 potassium voltage-gated channel, Shab-related subfami... 60 2e-08
gi|27436974 potassium voltage-gated channel, Shab-related subfam... 59 2e-08
gi|27436996 potassium voltage-gated channel, subfamily G, member... 55 3e-07
gi|6912444 potassium voltage-gated channel, subfamily G, member ... 55 4e-07
gi|27436984 potassium voltage-gated channel, Shal-related subfam... 52 3e-06
gi|27436986 potassium voltage-gated channel, Shal-related subfam... 52 3e-06
gi|27436988 potassium voltage-gated channel, subfamily G, member... 52 3e-06
gi|9789987 potassium voltage-gated channel, Shal-related subfami... 50 1e-05
gi|4826782 potassium voltage-gated channel, shaker-related subfa... 50 1e-05
gi|27436981 potassium voltage-gated channel, Shal-related subfam... 49 2e-05
gi|32479527 potassium voltage-gated channel, KQT-like subfamily,... 48 6e-05
gi|45383011 potassium voltage-gated channel, delayed-rectifier, ... 48 6e-05
gi|5031819 potassium voltage-gated channel, shaker-related subfa... 47 1e-04
gi|20070166 potassium voltage-gated channel, subfamily F, member... 47 1e-04
gi|24497460 Shaw-related voltage-gated potassium channel protein... 47 1e-04
gi|32479525 potassium voltage-gated channel, KQT-like subfamily,... 45 5e-04
gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens] 45 5e-04
gi|6912446 potassium voltage-gated channel, subfamily H, member ... 44 0.001
gi|4504831 potassium voltage-gated channel, subfamily H, member ... 44 0.001
gi|27437001 potassium voltage-gated channel, subfamily H, member... 44 0.001
gi|88758565 potassium voltage-gated channel, shaker-related subf... 43 0.002
gi|19424136 potassium channel, subfamily V, member 2 [Homo sapiens] 42 0.003
gi|26051268 potassium voltage-gated channel KQT-like protein 2 i... 42 0.003
>gi|157074214 potassium channel, subfamily U, member 1 [Homo sapiens]
Length = 1149
Score = 2305 bits (5972), Expect = 0.0
Identities = 1149/1149 (100%), Positives = 1149/1149 (100%)
Query: 1 MFQTKLRNETWEDLPKMSCTTEIQAAFILSSFVTFFSGLIILLIFRLIWRSVKKWQIIKG 60
MFQTKLRNETWEDLPKMSCTTEIQAAFILSSFVTFFSGLIILLIFRLIWRSVKKWQIIKG
Sbjct: 1 MFQTKLRNETWEDLPKMSCTTEIQAAFILSSFVTFFSGLIILLIFRLIWRSVKKWQIIKG 60
Query: 61 TGIILELFTSGTIARSHVRSLHFQGQFRDHIEMLLSAQTFVGQVLVILVFVLSIGSLIIY 120
TGIILELFTSGTIARSHVRSLHFQGQFRDHIEMLLSAQTFVGQVLVILVFVLSIGSLIIY
Sbjct: 61 TGIILELFTSGTIARSHVRSLHFQGQFRDHIEMLLSAQTFVGQVLVILVFVLSIGSLIIY 120
Query: 121 FINSADPVGSCSSYEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIP 180
FINSADPVGSCSSYEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIP
Sbjct: 121 FINSADPVGSCSSYEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIP 180
Query: 181 PTFISYYLKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAG 240
PTFISYYLKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAG
Sbjct: 181 PTFISYYLKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAG 240
Query: 241 FIHLVENSGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGS 300
FIHLVENSGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGS
Sbjct: 241 FIHLVENSGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGS 300
Query: 301 LILFANYIPEMVELFANKRKYTSSYEALKGKKFIVVCGNITVDSVTAFLRNFLRDKSGEI 360
LILFANYIPEMVELFANKRKYTSSYEALKGKKFIVVCGNITVDSVTAFLRNFLRDKSGEI
Sbjct: 301 LILFANYIPEMVELFANKRKYTSSYEALKGKKFIVVCGNITVDSVTAFLRNFLRDKSGEI 360
Query: 361 NTEIVFLGETPPSLELETIFKCYLAYTTFISGSAMKWEDLRRVAVESAEACLIIANPLCS 420
NTEIVFLGETPPSLELETIFKCYLAYTTFISGSAMKWEDLRRVAVESAEACLIIANPLCS
Sbjct: 361 NTEIVFLGETPPSLELETIFKCYLAYTTFISGSAMKWEDLRRVAVESAEACLIIANPLCS 420
Query: 421 DSHAEDISNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWNWDTGDNIICFAELKL 480
DSHAEDISNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWNWDTGDNIICFAELKL
Sbjct: 421 DSHAEDISNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWNWDTGDNIICFAELKL 480
Query: 481 GFIAQGCLVPGLCTFLTSLFVEQNKKVMPKQTWKKHFLNSMKNKILTQRLSDDFAGMSFP 540
GFIAQGCLVPGLCTFLTSLFVEQNKKVMPKQTWKKHFLNSMKNKILTQRLSDDFAGMSFP
Sbjct: 481 GFIAQGCLVPGLCTFLTSLFVEQNKKVMPKQTWKKHFLNSMKNKILTQRLSDDFAGMSFP 540
Query: 541 EVARLCFLKMHLLLIAIEYKSLFTDGFCGLILNPPPQVRIRKNTLGFFIAETPKDVRRAL 600
EVARLCFLKMHLLLIAIEYKSLFTDGFCGLILNPPPQVRIRKNTLGFFIAETPKDVRRAL
Sbjct: 541 EVARLCFLKMHLLLIAIEYKSLFTDGFCGLILNPPPQVRIRKNTLGFFIAETPKDVRRAL 600
Query: 601 FYCSVCHDDVFIPELITNCGCKSRSRQHITVPSVKRMKKCLKGISSRISGQDSPPRVSAS 660
FYCSVCHDDVFIPELITNCGCKSRSRQHITVPSVKRMKKCLKGISSRISGQDSPPRVSAS
Sbjct: 601 FYCSVCHDDVFIPELITNCGCKSRSRQHITVPSVKRMKKCLKGISSRISGQDSPPRVSAS 660
Query: 661 TSSISNFTTRTLQHDVEQDSDQLDSSGMFHWCKPTSLDKVTLKRTGKSKYKFRNHIVACV 720
TSSISNFTTRTLQHDVEQDSDQLDSSGMFHWCKPTSLDKVTLKRTGKSKYKFRNHIVACV
Sbjct: 661 TSSISNFTTRTLQHDVEQDSDQLDSSGMFHWCKPTSLDKVTLKRTGKSKYKFRNHIVACV 720
Query: 721 FGDAHSAPMGLRNFVMPLRASNYTRKELKDIVFIGSLDYLQREWRFLWNFPQIYILPGCA 780
FGDAHSAPMGLRNFVMPLRASNYTRKELKDIVFIGSLDYLQREWRFLWNFPQIYILPGCA
Sbjct: 721 FGDAHSAPMGLRNFVMPLRASNYTRKELKDIVFIGSLDYLQREWRFLWNFPQIYILPGCA 780
Query: 781 LYSGDLHAANIEQCSMCAVLSPPPQPSSNQTLVDTEAIMATLTIGSLQIDSSSDPSPSVS 840
LYSGDLHAANIEQCSMCAVLSPPPQPSSNQTLVDTEAIMATLTIGSLQIDSSSDPSPSVS
Sbjct: 781 LYSGDLHAANIEQCSMCAVLSPPPQPSSNQTLVDTEAIMATLTIGSLQIDSSSDPSPSVS 840
Query: 841 EETPGYTNGHNEKSNCRKVPILTELKNPSNIHFIEQLGGLEGSLQETNLHLSTAFSTGTV 900
EETPGYTNGHNEKSNCRKVPILTELKNPSNIHFIEQLGGLEGSLQETNLHLSTAFSTGTV
Sbjct: 841 EETPGYTNGHNEKSNCRKVPILTELKNPSNIHFIEQLGGLEGSLQETNLHLSTAFSTGTV 900
Query: 901 FSGSFLDSLLATAFYNYHVLELLQMLVTGGVSSQLEQHLDKDKVYGVADSCTSLLSGRNR 960
FSGSFLDSLLATAFYNYHVLELLQMLVTGGVSSQLEQHLDKDKVYGVADSCTSLLSGRNR
Sbjct: 901 FSGSFLDSLLATAFYNYHVLELLQMLVTGGVSSQLEQHLDKDKVYGVADSCTSLLSGRNR 960
Query: 961 CKLGLLSLHETILSDVNPRNTFGQLFCGSLDLFGILCVGLYRIIDEEELNPENKRFVITR 1020
CKLGLLSLHETILSDVNPRNTFGQLFCGSLDLFGILCVGLYRIIDEEELNPENKRFVITR
Sbjct: 961 CKLGLLSLHETILSDVNPRNTFGQLFCGSLDLFGILCVGLYRIIDEEELNPENKRFVITR 1020
Query: 1021 PANEFKLLPSDLVFCAIPFSTACYKRNEEFSLQKSYEIVNKASQTTETHSDTNCPPTIDS 1080
PANEFKLLPSDLVFCAIPFSTACYKRNEEFSLQKSYEIVNKASQTTETHSDTNCPPTIDS
Sbjct: 1021 PANEFKLLPSDLVFCAIPFSTACYKRNEEFSLQKSYEIVNKASQTTETHSDTNCPPTIDS 1080
Query: 1081 VTETLYSPVYSYQPRTNSLSFPKQIAWNQSRTNSIISSQIPLGDNAKENERKTSDEVYDE 1140
VTETLYSPVYSYQPRTNSLSFPKQIAWNQSRTNSIISSQIPLGDNAKENERKTSDEVYDE
Sbjct: 1081 VTETLYSPVYSYQPRTNSLSFPKQIAWNQSRTNSIISSQIPLGDNAKENERKTSDEVYDE 1140
Query: 1141 DPFAYSEPL 1149
DPFAYSEPL
Sbjct: 1141 DPFAYSEPL 1149
>gi|26638650 large conductance calcium-activated potassium channel
subfamily M alpha member 1 isoform b [Homo sapiens]
Length = 1178
Score = 890 bits (2300), Expect = 0.0
Identities = 477/1085 (43%), Positives = 671/1085 (61%), Gaps = 63/1085 (5%)
Query: 26 AFILSSFVTFFSGLIILLIFRLI---W--------RSVKKWQIIKGTGIILELFTSGTIA 74
AF+ SS VTFF GL I+L++R + W ++ + +I G+ GT+
Sbjct: 89 AFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQ-----ADGTLK 143
Query: 75 ------RSHVRSLHFQGQFRDHIEMLLSAQTFVGQVLVILVFVLSIGSLIIYFINSADPV 128
+ + + +D +++SAQT G+VLV+LVF LSIG+L+IYFI+S++P+
Sbjct: 144 PVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPI 203
Query: 129 GSCSS-YEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPPTFISYY 187
SC + Y+D T+ ID+ FN FF YFGLRF+AA+DK+ FWLE+NS+VD FT+PP F+S Y
Sbjct: 204 ESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVY 263
Query: 188 LKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAGFIHLVEN 247
L +WLGLRFLRALRL++ +ILQ L +KTSNS+K LLSI +STW TAAGFIHLVEN
Sbjct: 264 LNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVEN 323
Query: 248 SGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANY 307
SGDPW +N+Q ++Y+E +YL+M T STVG+GDV AKT+LGR F++FF LG L +FA+Y
Sbjct: 324 SGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASY 383
Query: 308 IPEMVELFANKRKYTSSYEALKGKKFIVVCGNITVDSVTAFLRNFLRDKSGEINTEIVFL 367
+PE++EL N++KY SY A+ G+K IVVCG+IT++SV+ FL++FL ++N EIVFL
Sbjct: 384 VPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFL 443
Query: 368 GETPPSLELETIFKCYLAYTTFISGSAMKWEDLRRVAVESAEACLIIANPLCSDSHAEDI 427
P+LELE +FK + F GS + DL RV +ESA+ACLI+AN C+D AED
Sbjct: 444 HNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDA 503
Query: 428 SNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWNWDTGDNIICFAELKLGFIAQGC 487
SNIMRV+SIKNY RII Q+LQ HNK +L IPSWNW GD+ IC AELKLGFIAQ C
Sbjct: 504 SNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSC 563
Query: 488 LVPGLCTFLTSLFVEQNKKVMPKQTWKKHFLNSMKNKILTQRLSDDFAGMSFPEVARLCF 547
L GL T L +LF ++ + + TW+K++L + N++ T+ LS F G+SFP V LCF
Sbjct: 564 LAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCF 623
Query: 548 LKMHLLLIAIEYKSLFTDGFCGLILNPPPQVRIRKNTLGFFIAETPKDVRRALFYCSVCH 607
+K+ LL+IAIEYKS + +++NP ++I++ TLGFFIA K+V+RA FYC CH
Sbjct: 624 VKLKLLMIAIEYKSANRES--RILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACH 681
Query: 608 DDVFIPELITNCGCKSRSRQHITVPSVKRMKKCLKGISSRISGQDSP------PRVSAST 661
DD+ P+ I CGCK R PS KK + R S SP P +
Sbjct: 682 DDITDPKRIKKCGCK---RLEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGN 738
Query: 662 SSISNFTTRTLQHDVEQDSDQLDSSGMFHWCKPTSLDKVTLKRTGKSKYKFRNHIVACVF 721
I N ++ + + DS+GMFHWC P ++KV L R+ + H+V C+F
Sbjct: 739 DQIDN---------MDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIF 789
Query: 722 GDAHSAPMGLRNFVMPLRASNYTRKELKDIVFIGSLDYLQREWRFLWNFPQIYILPGCAL 781
GD SA +GLRN VMPLRASN+ ELK IVF+GS++YL+REW L NFP++ ILPG L
Sbjct: 790 GDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPL 849
Query: 782 YSGDLHAANIEQCSMCAVLSPPPQPSSNQTLVDTEAIMATLTIGSLQIDSSSDPSPSVSE 841
DL A NI C MC +LS + +L D E I+A+L I S+Q D S + S+
Sbjct: 850 SRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQ 909
Query: 842 --ETPGYTNGHNEKSNCR------------KVPILTELKNPSNIHFIEQLGGLEGSLQET 887
PG + S +PI+TEL N +N+ F++Q + +T
Sbjct: 910 GFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQ---DDDDDPDT 966
Query: 888 NLHLSTAFSTGTVFSGSFLDSLLATAFYNYHVLELLQMLVTGGVSSQLEQHLDKDKVYGV 947
L+L+ F+ GT F+ S LDSL++ ++N ++L L++ LVTGG + +LE + ++
Sbjct: 967 ELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRG 1026
Query: 948 ADSCTSLLSGRNRCKLGLLSLHETILSDVNPRNTFGQLFCGSLDLFGILCVGLYRIIDEE 1007
S L+ R+RC++ L+L + +D+ +G LFC +L + +LC G+YR+ D
Sbjct: 1027 GYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAH 1086
Query: 1008 ELNPE--NKRFVITRPANEFKLLPSDLVFCAIPFSTACYKRNEEFSLQKSYEIVNKASQT 1065
P KR+VIT P EF+L+P+DL+FC + F + S S+ + + ++
Sbjct: 1087 LSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLS-HSSHSSQSSSKKS 1145
Query: 1066 TETHS 1070
+ HS
Sbjct: 1146 SSVHS 1150
>gi|62388890 large conductance calcium-activated potassium channel
subfamily M alpha member 1 isoform a [Homo sapiens]
Length = 1182
Score = 889 bits (2296), Expect = 0.0
Identities = 477/1087 (43%), Positives = 671/1087 (61%), Gaps = 63/1087 (5%)
Query: 26 AFILSSFVTFFSGLIILLIFRLI---W--------RSVKKWQIIKGTGIILELFTSGTIA 74
AF+ SS VTFF GL I+L++R + W ++ + +I G+ GT+
Sbjct: 89 AFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQ-----ADGTLK 143
Query: 75 ------RSHVRSLHFQGQFRDHIEMLLSAQTFVGQVLVILVFVLSIGSLIIYFINSADPV 128
+ + + +D +++SAQT G+VLV+LVF LSIG+L+IYFI+S++P+
Sbjct: 144 PVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPI 203
Query: 129 GSCSS-YEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPPTFISYY 187
SC + Y+D T+ ID+ FN FF YFGLRF+AA+DK+ FWLE+NS+VD FT+PP F+S Y
Sbjct: 204 ESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVY 263
Query: 188 LKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAGFIHLVEN 247
L +WLGLRFLRALRL++ +ILQ L +KTSNS+K LLSI +STW TAAGFIHLVEN
Sbjct: 264 LNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVEN 323
Query: 248 SGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANY 307
SGDPW +N+Q ++Y+E +YL+M T STVG+GDV AKT+LGR F++FF LG L +FA+Y
Sbjct: 324 SGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASY 383
Query: 308 IPEMVELFANKRKYTSSYEALKGKKFIVVCGNITVDSVTAFLRNFLRDKSGEINTEIVFL 367
+PE++EL N++KY SY A+ G+K IVVCG+IT++SV+ FL++FL ++N EIVFL
Sbjct: 384 VPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFL 443
Query: 368 GETPPSLELETIFKCYLAYTTFISGSAMKWEDLRRVAVESAEACLIIANPLCSDSHAEDI 427
P+LELE +FK + F GS + DL RV +ESA+ACLI+AN C+D AED
Sbjct: 444 HNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDA 503
Query: 428 SNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWNWDTGDNIICFAELKLGFIAQGC 487
SNIMRV+SIKNY RII Q+LQ HNK +L IPSWNW GD+ IC AELKLGFIAQ C
Sbjct: 504 SNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSC 563
Query: 488 LVPGLCTFLTSLFVEQNKKVMPKQTWKKHFLNSMKNKILTQRLSDDFAGMSFPEVARLCF 547
L GL T L +LF ++ + + TW+K++L + N++ T+ LS F G+SFP V LCF
Sbjct: 564 LAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCF 623
Query: 548 LKMHLLLIAIEYKSLFTDGFC--GLILNPPPQVRIRKNTLGFFIAETPKDVRRALFYCSV 605
+K+ LL+IAIEYKS + +++NP ++I++ TLGFFIA K+V+RA FYC
Sbjct: 624 VKLKLLMIAIEYKSANRESRSRKRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKA 683
Query: 606 CHDDVFIPELITNCGCKSRSRQHITVPSVKRMKKCLKGISSRISGQDSP------PRVSA 659
CHDD+ P+ I CGCK R PS KK + R S SP P +
Sbjct: 684 CHDDITDPKRIKKCGCK---RLEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIP 740
Query: 660 STSSISNFTTRTLQHDVEQDSDQLDSSGMFHWCKPTSLDKVTLKRTGKSKYKFRNHIVAC 719
I N ++ + + DS+GMFHWC P ++KV L R+ + H+V C
Sbjct: 741 GNDQIDN---------MDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVC 791
Query: 720 VFGDAHSAPMGLRNFVMPLRASNYTRKELKDIVFIGSLDYLQREWRFLWNFPQIYILPGC 779
+FGD SA +GLRN VMPLRASN+ ELK IVF+GS++YL+REW L NFP++ ILPG
Sbjct: 792 IFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGT 851
Query: 780 ALYSGDLHAANIEQCSMCAVLSPPPQPSSNQTLVDTEAIMATLTIGSLQIDSSSDPSPSV 839
L DL A NI C MC +LS + +L D E I+A+L I S+Q D S +
Sbjct: 852 PLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQAN 911
Query: 840 SE--ETPGYTNGHNEKSNCR------------KVPILTELKNPSNIHFIEQLGGLEGSLQ 885
S+ PG + S +PI+TEL N +N+ F++Q +
Sbjct: 912 SQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQ---DDDDDP 968
Query: 886 ETNLHLSTAFSTGTVFSGSFLDSLLATAFYNYHVLELLQMLVTGGVSSQLEQHLDKDKVY 945
+T L+L+ F+ GT F+ S LDSL++ ++N ++L L++ LVTGG + +LE + ++
Sbjct: 969 DTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENAL 1028
Query: 946 GVADSCTSLLSGRNRCKLGLLSLHETILSDVNPRNTFGQLFCGSLDLFGILCVGLYRIID 1005
S L+ R+RC++ L+L + +D+ +G LFC +L + +LC G+YR+ D
Sbjct: 1029 RGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRD 1088
Query: 1006 EEELNPE--NKRFVITRPANEFKLLPSDLVFCAIPFSTACYKRNEEFSLQKSYEIVNKAS 1063
P KR+VIT P EF+L+P+DL+FC + F + S S+ + +
Sbjct: 1089 AHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLS-HSSHSSQSSSK 1147
Query: 1064 QTTETHS 1070
+++ HS
Sbjct: 1148 KSSSVHS 1154
>gi|238624130 large conductance calcium-activated potassium channel
subfamily M alpha member 1 isoform c [Homo sapiens]
Length = 1236
Score = 878 bits (2269), Expect = 0.0
Identities = 477/1132 (42%), Positives = 680/1132 (60%), Gaps = 99/1132 (8%)
Query: 26 AFILSSFVTFFSGLIILLIFRLI---W--------RSVKKWQIIKGTGIILELFTSGTIA 74
AF+ SS VTFF GL I+L++R + W ++ + +I G+ GT+
Sbjct: 89 AFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQ-----ADGTLK 143
Query: 75 ------RSHVRSLHFQGQFRDHIEMLLSAQTFVGQVLVILVFVLSIGSLIIYFINSADPV 128
+ + + +D +++SAQT G+VLV+LVF LSIG+L+IYFI+S++P+
Sbjct: 144 PVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPI 203
Query: 129 GSCSS-YEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPPTFISYY 187
SC + Y+D T+ ID+ FN FF YFGLRF+AA+DK+ FWLE+NS+VD FT+PP F+S Y
Sbjct: 204 ESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVY 263
Query: 188 LKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAGFIHLVEN 247
L +WLGLRFLRALRL++ +ILQ L +KTSNS+K LLSI +STW TAAGFIHLVEN
Sbjct: 264 LNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVEN 323
Query: 248 SGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANY 307
SGDPW +N+Q ++Y+E +YL+M T STVG+GDV AKT+LGR F++FF LG L +FA+Y
Sbjct: 324 SGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASY 383
Query: 308 IPEMVELFANKRKYTSSYEALKGKKFIVVCGNITVDSVTAFLRNFLRDKSGEINTEIVFL 367
+PE++EL N++KY SY A+ G+K IVVCG+IT++SV+ FL++FL ++N EIVFL
Sbjct: 384 VPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFL 443
Query: 368 GETPPSLELETIFKCYLAYTTFISGSAMKWEDLRRVAVESAEACLIIANPLCSDSHAEDI 427
P+LELE +FK + F GS + DL RV +ESA+ACLI+AN C+D AED
Sbjct: 444 HNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDA 503
Query: 428 SNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWNWDTGDNIICFAELKLGFIAQGC 487
SNIMRV+SIKNY RII Q+LQ HNK +L IPSWNW GD+ IC AELKLGFIAQ C
Sbjct: 504 SNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSC 563
Query: 488 LVPGLCTFLTSLFVEQNKKVMPKQTWKKHFLNSMKNKILTQRLSDDFAGMSFPEVARLCF 547
L GL T L +LF ++ + + TW+K++L + N++ T+ LS F G+SFP V LCF
Sbjct: 564 LAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCF 623
Query: 548 LKMHLLLIAIEYKSLFTDGFCGLILNPPPQVRIRKNTLGFFIAETPKDVRRALFYCSVCH 607
+K+ LL+IAIEYKS + +++NP ++I++ TLGFFIA K+V+RA FYC CH
Sbjct: 624 VKLKLLMIAIEYKSANRES--RILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACH 681
Query: 608 DDVFIPELITNCGCK-------SRSRQHITVPSVKRMKKCLKGISSRISGQDSPPRVSAS 660
DD+ P+ I CGCK R R+ + + C +S R+ G +
Sbjct: 682 DDITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERDC-SCMSGRVRGNVDTLERAFP 740
Query: 661 TSSIS----------------------------------NFTTRTLQHD----------- 675
SS+S N + + ++HD
Sbjct: 741 LSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQID 800
Query: 676 -VEQDSDQLDSSGMFHWCKPTSLDKVTLKRTGKSKYKFRNHIVACVFGDAHSAPMGLRNF 734
++ + + DS+GMFHWC P ++KV L R+ + H+V C+FGD SA +GLRN
Sbjct: 801 NMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNL 860
Query: 735 VMPLRASNYTRKELKDIVFIGSLDYLQREWRFLWNFPQIYILPGCALYSGDLHAANIEQC 794
VMPLRASN+ ELK IVF+GS++YL+REW L NFP++ ILPG L DL A NI C
Sbjct: 861 VMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLC 920
Query: 795 SMCAVLSPPPQPSSNQTLVDTEAIMATLTIGSLQIDSSSDPSPSVSE--ETPGYTNGHNE 852
MC +LS + +L D E I+A+L I S+Q D S + S+ PG +
Sbjct: 921 DMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPD 980
Query: 853 KSNCR------------KVPILTELKNPSNIHFIEQLGGLEGSLQETNLHLSTAFSTGTV 900
S +PI+TEL N +N+ F++Q + +T L+L+ F+ GT
Sbjct: 981 NSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQ---DDDDDPDTELYLTQPFACGTA 1037
Query: 901 FSGSFLDSLLATAFYNYHVLELLQMLVTGGVSSQLEQHLDKDKVYGVADSCTSLLSGRNR 960
F+ S LDSL++ ++N ++L L++ LVTGG + +LE + ++ S L+ R+R
Sbjct: 1038 FAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDR 1097
Query: 961 CKLGLLSLHETILSDVNPRNTFGQLFCGSLDLFGILCVGLYRIIDEEELNPE--NKRFVI 1018
C++ L+L + +D+ +G LFC +L + +LC G+YR+ D P KR+VI
Sbjct: 1098 CRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVI 1157
Query: 1019 TRPANEFKLLPSDLVFCAIPFSTACYKRNEEFSLQKSYEIVNKASQTTETHS 1070
T P EF+L+P+DL+FC + F + S S+ + + +++ HS
Sbjct: 1158 TNPPYEFELVPTDLIFCLMQFDHNAGQSRASLS-HSSHSSQSSSKKSSSVHS 1208
>gi|238624132 large conductance calcium-activated potassium channel
subfamily M alpha member 1 isoform d [Homo sapiens]
Length = 1219
Score = 871 bits (2251), Expect = 0.0
Identities = 481/1127 (42%), Positives = 674/1127 (59%), Gaps = 106/1127 (9%)
Query: 26 AFILSSFVTFFSGLIILLIFRLI---W--------RSVKKWQIIKGTGIILELFTSGTIA 74
AF+ SS VTFF GL I+L++R + W ++ + +I G+ GT+
Sbjct: 89 AFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQ-----ADGTLK 143
Query: 75 ------RSHVRSLHFQGQFRDHIEMLLSAQTFVGQVLVILVFVLSIGSLIIYFINSADPV 128
+ + + +D +++SAQT G+VLV+LVF LSIG+L+IYFI+S++P+
Sbjct: 144 PVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPI 203
Query: 129 GSCSS-YEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPPTFISYY 187
SC + Y+D T+ ID+ FN FF YFGLRF+AA+DK+ FWLE+NS+VD FT+PP F+S Y
Sbjct: 204 ESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVY 263
Query: 188 LKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAGFIHLVEN 247
L +WLGLRFLRALRL++ +ILQ L +KTSNS+K LLSI +STW TAAGFIHLVEN
Sbjct: 264 LNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVEN 323
Query: 248 SGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANY 307
SGDPW +N+Q ++Y+E +YL+M T STVG+GDV AKT+LGR F++FF LG L +FA+Y
Sbjct: 324 SGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASY 383
Query: 308 IPEMVELFANKRKYTSSYEALKGKKFIVVCGNITVDSVTAFLRNFLRDKSGEINTEIVFL 367
+PE++EL N++KY SY A+ G+K IVVCG+IT++SV+ FL++FL ++N EIVFL
Sbjct: 384 VPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFL 443
Query: 368 GETPPSLELETIFKCYLAYTTFISGSAMKWEDLRRVAVESAEACLIIANPLCSDSHAEDI 427
P+LELE +FK + F GS + DL RV +ESA+ACLI+AN C+D AED
Sbjct: 444 HNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDA 503
Query: 428 SNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWNWDTGDNIICFAELKLGFIAQGC 487
SNIMRV+SIKNY RII Q+LQ HNK +L IPSWNW GD+ IC AELKLGFIAQ C
Sbjct: 504 SNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSC 563
Query: 488 LVPGLCTFLTSLFVEQNKKVMPKQTWKKHFLNSMKNKILTQRLSDDFAGMSFPEVARLCF 547
L GL T L +LF ++ + + TW+K++L + N++ T+ LS F G+SFP V LCF
Sbjct: 564 LAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCF 623
Query: 548 LKMHLLLIAIEYKSLFTDGFCGLILNPPPQVRIRKNTLGFFIAETPKDVRRALFYCSVCH 607
+K+ LL+IAIEYKS + +++NP ++I++ TLGFFIA K+V+RA FYC CH
Sbjct: 624 VKLKLLMIAIEYKSANRES--RILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACH 681
Query: 608 DDVFIPELITNCGCKSRSRQHITVPSVKRMKKCLKGISSRISGQDSP------PRVSAST 661
DD+ P+ I CGCK R PS KK + R S SP P +
Sbjct: 682 DDITDPKRIKKCGCK---RLEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGN 738
Query: 662 SSISNFTTRTLQHDVEQDSDQLDSSGMFHWCKPTSLDKVTLKRTGKSKY----------- 710
I N ++ + + DS+GMFHWC P ++KV L TG Y
Sbjct: 739 DQIDN---------MDSNVKKYDSTGMFHWCAPKEIEKVILV-TGWMPYLGPRVLMTCLD 788
Query: 711 -------------------KFR------------NHIVACVFGDAHSAPMGLRNFVMPLR 739
KF+ H+V C+FGD SA +GLRN VMPLR
Sbjct: 789 IGVVCMPTDIQSTSPASIKKFKETRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLR 848
Query: 740 ASNYTRKELKDIVFIGSLDYLQREWRFLWNFPQIYILPGCALYSGDLHAANIEQCSMCAV 799
ASN+ ELK IVF+GS++YL+REW L NFP++ ILPG L DL A NI C MC +
Sbjct: 849 ASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVI 908
Query: 800 LSPPPQPSSNQTLVDTEAIMATLTIGSLQIDSSSDPSPSVSE--ETPGYTNGHNEKSNCR 857
LS + +L D E I+A+L I S+Q D S + S+ PG + S
Sbjct: 909 LSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVH 968
Query: 858 ------------KVPILTELKNPSNIHFIEQLGGLEGSLQETNLHLSTAFSTGTVFSGSF 905
+PI+TEL N +N+ F++Q + +T L+L+ F+ GT F+ S
Sbjct: 969 GMLRQPSITTGVNIPIITELVNDTNVQFLDQ---DDDDDPDTELYLTQPFACGTAFAVSV 1025
Query: 906 LDSLLATAFYNYHVLELLQMLVTGGVSSQLEQHLDKDKVYGVADSCTSLLSGRNRCKLGL 965
LDSL++ ++N ++L L++ LVTGG + +LE + ++ S L+ R+RC++
Sbjct: 1026 LDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQ 1085
Query: 966 LSLHETILSDVNPRNTFGQLFCGSLDLFGILCVGLYRIIDEEELNPE--NKRFVITRPAN 1023
L+L + +D+ +G LFC +L + +LC G+YR+ D P KR+VIT P
Sbjct: 1086 LALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPY 1145
Query: 1024 EFKLLPSDLVFCAIPFSTACYKRNEEFSLQKSYEIVNKASQTTETHS 1070
EF+L+P+DL+FC + F + S S+ + + +++ HS
Sbjct: 1146 EFELVPTDLIFCLMQFDHNAGQSRASLS-HSSHSSQSSSKKSSSVHS 1191
>gi|41349443 potassium channel, subfamily T, member 2 [Homo sapiens]
Length = 1135
Score = 142 bits (358), Expect = 2e-33
Identities = 199/850 (23%), Positives = 353/850 (41%), Gaps = 161/850 (18%)
Query: 168 LEMNSIVDIFTIPPTFISYYLKSNWLGLRFL---------RALRLLELPQILQILRAIKT 218
L + I++I P IS + W LR L A LE I + RAI+
Sbjct: 136 LRIPFILEIINAVPFIISIF----WPSLRNLFVPVFLNCWLAKHALE-NMINDLHRAIQR 190
Query: 219 SNSVKFSK---LLSIILSTWFTAAGFIHLVENSGDPWLKGRNSQNISYFESIYLVMATTS 275
+ S F++ L+S +L FT I +E G + ++ F+S+Y + T S
Sbjct: 191 TQSAMFNQVLILISTLLCLIFTCICGIQHLERIG---------KKLNLFDSLYFCIVTFS 241
Query: 276 TVGFGDVVAKTSLGRTFIMFFTLGSLILFANYIPEMVELFANKRKYTSSYEALKGK--KF 333
TVGFGDV +T + F++ +L++ ++ L+ ++K +Y + + K
Sbjct: 242 TVGFGDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYLWMERQKSGGNYSRHRAQTEKH 301
Query: 334 IVVC-GNITVDSVTAFLRNFLRDKSGEINTEIVFLGETPPSLELETIFKC--YLAYTTFI 390
+V+C ++ +D + FL F + + +V L T +++ + + + ++
Sbjct: 302 VVLCVSSLKIDLLMDFLNEFYAHPRLQ-DYYVVILCPTEMDVQVRRVLQIPMWSQRVIYL 360
Query: 391 SGSAMKWEDLRRVAVESAEACLIIANPLCSDSHAEDISNIMRVLSIKNYDSTTRIIIQIL 450
GSA+K +DL R ++ AEAC I+++ D + D I+R ++K++ + +QIL
Sbjct: 361 QGSALKDQDLLRAKMDDAEACFILSSRCEVDRTSSDHQTILRAWAVKDFAPNCPLYVQIL 420
Query: 451 QSHNKVYLPKIPSWNWDTGDNIICFAELKLGFIAQGCLVPGLCTFLTSLFVE---QNKKV 507
+ NK ++ D+++C E K +A C+ P T +T L Q +
Sbjct: 421 KPENKFHI--------KFADHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQEGQQ 472
Query: 508 MPKQTWKKHFLNSMKNKILTQRLSD-----DFAGMSFPEVARLCFLKMHLLLIAIEYKSL 562
P+Q W+K + N++ L + ++ G SF + K + LI +
Sbjct: 473 SPEQ-WQKMYGRCSGNEVYHIVLEESTFFAEYEGKSFTYASFHAHKKFGVCLIGVR---- 527
Query: 563 FTDGFCGLILNPPPQVRIRKNTLGFFIAETPKD---------VRRALFYCSVCHDDVFIP 613
+ ++LNP P+ + + F+I T ++ R++ S H +P
Sbjct: 528 -REDNKNILLNPGPRYIMNSTDICFYINITKEENSAFKNQDQQRKSNVSRSFYHGPSRLP 586
Query: 614 --ELITNCG----------CKSRSRQHITVPSVKRMKKCLKGISSRISGQDSPPRVSAST 661
+I + G C+S S +++P+ +G +P A T
Sbjct: 587 VHSIIASMGTVAIDLQDTSCRSASGPTLSLPT--------EGSKEIRRPSIAPVLEVADT 638
Query: 662 SSISNFTTRTLQHDVEQDSDQLDSSGM-----------FHWCKPTSLDKVTLK------R 704
SSI + Q + E D+ SS + + PT + K R
Sbjct: 639 SSIQTCDLLSDQSEDETTPDEEMSSNLEYAKGYPPYSPYIGSSPTFCHLLHEKVPFCCLR 698
Query: 705 TGKS----------KYKFRNHIVACVFGDAHSAPMGLRNFVMPLRASNYTRKELKDIVFI 754
KS Y F+N ++ A +A GL NF++PLRA +KEL IV +
Sbjct: 699 LDKSCQHNYYEDAKAYGFKNKLIIVA---AETAGNGLYNFIVPLRAYYRPKKELNPIVLL 755
Query: 755 GSLDYLQREWRFL----WNFPQIYILPGCALYSGDLHAANIEQCSMCAVLSPPPQPSSNQ 810
LD + FL W FP +Y + G N++ C V ++N
Sbjct: 756 --LDN-PPDMHFLDAICW-FPMVYYMVG--------SIDNLDDLLRCGVTF-----AANM 798
Query: 811 TLVDTEAIMATLTIGSLQIDSSSDPSPSVSEETPGYTNGHNEKSNCRKVPILTELKNPSN 870
+VD E+ M S + D +D V+ +T + I+TEL +P+N
Sbjct: 799 VVVDKESTM------SAEEDYMADAKTIVNVQTLFRL--------FSSLSIITELTHPAN 844
Query: 871 IHFIE---------QLGGLEGSLQETNLHLS----TAFSTGTVFSGSFLDSLLATAFYNY 917
+ F++ L LE +E +L+ F+ G VFS S LD+LL +F
Sbjct: 845 MRFMQFRAKDCYSLALSKLEKKERERGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKD 904
Query: 918 HVLELLQMLV 927
+++ + ++L+
Sbjct: 905 YMISITRLLL 914
>gi|240255505 potassium channel, subfamily T, member 1 [Homo
sapiens]
Length = 1235
Score = 112 bits (280), Expect = 2e-24
Identities = 113/461 (24%), Positives = 207/461 (44%), Gaps = 54/461 (11%)
Query: 163 KIKFWLEM-NSIVDIFTI--PPT---FISYYLKSNWLGLRFLRALRLLELPQILQILRAI 216
++ F LEM N++ I TI PP FI +L WL L + I RAI
Sbjct: 209 RVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNC-WLAKHALENM-------INDFHRAI 260
Query: 217 KTSNSVKFSKLLSI---ILSTWFTAAGFIHLVENSGDPWLKGRNSQNISYFESIYLVMAT 273
+ S F+++L + +L FT I +E +G+ N+S S Y + T
Sbjct: 261 LRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGE---------NLSLLTSFYFCIVT 311
Query: 274 TSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANYIPEMVELFANKRKYTSSYEALKGK-- 331
STVG+GDV K + ++ +L++ E+V L+ ++K +Y + +
Sbjct: 312 FSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTE 371
Query: 332 KFIVVC-GNITVDSVTAFLRNFLRDKSGEINTEIVFLGETPPSLELETIFKCYL--AYTT 388
K +V+C ++ +D + FL F + + +V L T +++ + + L
Sbjct: 372 KHVVLCVSSLKIDLLMDFLNEFYAHPRLQ-DYYVVILCPTEMDVQVRRVLQIPLWSQRVI 430
Query: 389 FISGSAMKWEDLRRVAVESAEACLIIANPLCSDSHAEDISNIMRVLSIKNYDSTTRIIIQ 448
++ GSA+K +DL R +++ EAC I+++ D A D I+R ++K++ + +Q
Sbjct: 431 YLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKDFAPNCPLYVQ 490
Query: 449 ILQSHNKVYLPKIPSWNWDTGDNIICFAELKLGFIAQGCLVPGLCTFLTSLFVE---QNK 505
IL+ NK ++ D+++C E K +A C+ P T +T L Q
Sbjct: 491 ILKPENKFHV--------KFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEG 542
Query: 506 KVMPKQTWKKHFLNSMKNKILTQRLSD-----DFAGMSFPEVARLCFLKMHLLLIAIEYK 560
+ P+Q W++ + N++ R+ D ++ G SF A K + LI ++
Sbjct: 543 QESPEQ-WQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLK-- 599
Query: 561 SLFTDGFCGLILNPPPQVRIRKNTLGFFIAETPKDVRRALF 601
+ ++LNP P+ + + F+I T ++ +F
Sbjct: 600 ---REDNKSILLNPGPRHILAASDTCFYINITKEENSAFIF 637
Score = 57.8 bits (138), Expect = 6e-08
Identities = 60/231 (25%), Positives = 100/231 (43%), Gaps = 43/231 (18%)
Query: 710 YKFRNHIVACVFGDAHSAPMGLRNFVMPLRASNYTRKELKDIVFIGSLDYLQREWRFLWN 769
Y F+N ++ A +A GL NF++PLRA +RKEL IV + +
Sbjct: 796 YGFKNKLIIV---SAETAGNGLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAICC 852
Query: 770 FPQIYILPGCALYSGDLHAANIEQCSMCAVLSPPPQPSSNQTLVDTEAIMATLTIGSLQI 829
FP +Y + G N++ C ++ + N +VD E+ M S +
Sbjct: 853 FPMVYYMEG--------SVDNLDSLLQCGIIY-----ADNLVVVDKESTM------SAEE 893
Query: 830 DSSSDPSPSVSEETPGYTNGHNEKSNCRKVPILTELKNPSNIHFIE---------QLGGL 880
D +D V+ +T + I TEL +PSN+ F++ L L
Sbjct: 894 DYMADAKTIVNVQTMFRL--------FPSLSITTELTHPSNMRFMQFRAKDSYSLALSKL 945
Query: 881 EGSLQETNLHLS----TAFSTGTVFSGSFLDSLLATAFYNYHVLELLQMLV 927
E +E +L+ F+ G VFS S LD+LL +F +++ + ++L+
Sbjct: 946 EKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLL 996
>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
member 1 [Homo sapiens]
Length = 858
Score = 59.7 bits (143), Expect = 2e-08
Identities = 53/229 (23%), Positives = 107/229 (46%), Gaps = 15/229 (6%)
Query: 103 QVLVILVFVLSIGSLIIYFINSADPVGSCSSYEDKT-----IPIDLVFNAFFSFYFGLRF 157
++L I+ + + S I +N+ + S + T ++ V A+F+ + LRF
Sbjct: 189 KILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRF 248
Query: 158 MAADDKIKFWLEMNSIVDIFTIPPTFISYYL-KSNWLGLRFLRALRLLELPQILQILRAI 216
+++ K KF+ + +D+ I P +++ +L +SN L+F R++++ +I++ILR +
Sbjct: 249 LSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRIL 308
Query: 217 KTSNSVKFSKLLSIILSTWFTAAGFIHLVENSGDPWLKG-----RNSQNISYFESI---- 267
K + + L L + G + L G ++ + F+SI
Sbjct: 309 KLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASF 368
Query: 268 YLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANYIPEMVELFA 316
+ T +TVG+GD+ KT LG+ + +++ A IP +V F+
Sbjct: 369 WWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFS 417
>gi|27436974 potassium voltage-gated channel, Shab-related
subfamily, member 2 [Homo sapiens]
Length = 911
Score = 59.3 bits (142), Expect = 2e-08
Identities = 53/225 (23%), Positives = 105/225 (46%), Gaps = 12/225 (5%)
Query: 104 VLVILVFVLSIGSLIIYFINSADPVGSCSSYED--KTIPIDLVFNAFFSFYFGLRFMAAD 161
++ IL VLS +L + + D + ++ V A+F+ + LRF+++
Sbjct: 197 IVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSP 256
Query: 162 DKIKFWLEMNSIVDIFTIPPTFISYYL-KSNWLGLRFLRALRLLELPQILQILRAIKTSN 220
+K KF+ +++D+ I P +++ +L +SN L+F R++++ +I++ILR +K +
Sbjct: 257 NKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLAR 316
Query: 221 SVKFSKLLSIILSTWFTAAGFIHLVENSGDPWLK-----GRNSQNISYFESI----YLVM 271
+ L L + G + L G ++ + F SI +
Sbjct: 317 HSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWAT 376
Query: 272 ATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANYIPEMVELFA 316
T +TVG+GD+ KT LG+ + +++ A IP +V F+
Sbjct: 377 ITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFS 421
>gi|27436996 potassium voltage-gated channel, subfamily G, member 4
[Homo sapiens]
Length = 519
Score = 55.5 bits (132), Expect = 3e-07
Identities = 51/207 (24%), Positives = 91/207 (43%), Gaps = 28/207 (13%)
Query: 122 INSADPVGSCSSYEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPP 181
+ + + G CS ++ + A+FS F LRF+ A DK +F+ +I+DI I P
Sbjct: 246 LRAEEDQGECSRKCYYIFIVETICVAWFSLEFCLRFVQAQDKCQFFQGPLNIIDILAISP 305
Query: 182 TFISY-----------------YLKSNWLGLRFLRALRLLELPQI------LQILRAIKT 218
++S YL+ L LR LRALR+L + ++ LQ L
Sbjct: 306 YYVSLAVSEEPPEDGERPSGSSYLEKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTVR 365
Query: 219 SNSVKFSKLLSIILSTWFTAAGFIHLVENSGDPWLKGRNSQNISYFESIYLVMATTSTVG 278
+ +F LL + + +++ E GR + S S + + + +TVG
Sbjct: 366 RCTREFGLLLLFLAVAITLFSPLVYVAEKE-----SGRVLEFTSIPASYWWAIISMTTVG 420
Query: 279 FGDVVAKTSLGRTFIMFFTLGSLILFA 305
+GD+V ++ G+ + L +++ A
Sbjct: 421 YGDMVPRSVPGQMVALSSILSGILIMA 447
>gi|6912444 potassium voltage-gated channel, subfamily G, member 2
[Homo sapiens]
Length = 466
Score = 55.1 bits (131), Expect = 4e-07
Identities = 62/246 (25%), Positives = 102/246 (41%), Gaps = 31/246 (12%)
Query: 104 VLVILVFVLSIGSLIIYF--INSADPVGSCSSYEDKTIPIDLVFNAFFSFYFGLRFMAAD 161
V V V V ++G + I + + G CS ++ V A+FSF F LR + A+
Sbjct: 182 VSVSFVAVTAVGLCLSTMPDIRAEEERGECSPKCRSLFVLETVCVAWFSFEFLLRSLQAE 241
Query: 162 DKIKFWLEMNSIVDIFTIPPTFISY------------YLKSNWLGLRFLRALRLLELPQI 209
K F +I+DI + P ++S L+ L LR LRALR+L + ++
Sbjct: 242 SKCAFLRAPLNIIDILALLPFYVSLLLGLAAGPGGTKLLERAGLVLRLLRALRVLYVMRL 301
Query: 210 ------LQILRAIKTSNSVKFSKLLSIILSTWFTAAGFIHLVENSGDPWLKGRNSQNISY 263
L+ L + +F LL + A +HL E G S
Sbjct: 302 ARHSLGLRSLGLTMRRCAREFGLLLLFLCVAMALFAPLVHLAERE-----LGARRDFSSV 356
Query: 264 FESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANYIPEMVELFANKRKYTS 323
S + + + +TVG+GD+V ++ G+ + L ++L A + + F+
Sbjct: 357 PASYWWAVISMTTVGYGDMVPRSLPGQVVALSSILSGILLMAFPVTSIFHTFSR------ 410
Query: 324 SYEALK 329
SY LK
Sbjct: 411 SYSELK 416
>gi|27436984 potassium voltage-gated channel, Shal-related
subfamily, member 3 isoform 1 [Homo sapiens]
Length = 655
Score = 52.0 bits (123), Expect = 3e-06
Identities = 45/186 (24%), Positives = 83/186 (44%), Gaps = 17/186 (9%)
Query: 141 IDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPPTFISYYLKSN------WLG 194
+D F+ + LR AA + +F + SI+D+ I P +I + +N ++
Sbjct: 229 LDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVT 288
Query: 195 LRFLRALRLLELPQILQILR----AIKTSNSVKFSKLLSIILSTWFTAAGFIHLVENSGD 250
LR R R+ + + Q LR +K+ S L S+ ++ A + + S
Sbjct: 289 LRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSA 348
Query: 251 PWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANYIPE 310
S+ S S + + T +T+G+GD+V KT G+ F +L +++ A +P
Sbjct: 349 -------SKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPV 401
Query: 311 MVELFA 316
+V F+
Sbjct: 402 IVSNFS 407
>gi|27436986 potassium voltage-gated channel, Shal-related
subfamily, member 3 isoform 2 [Homo sapiens]
Length = 636
Score = 52.0 bits (123), Expect = 3e-06
Identities = 45/186 (24%), Positives = 83/186 (44%), Gaps = 17/186 (9%)
Query: 141 IDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPPTFISYYLKSN------WLG 194
+D F+ + LR AA + +F + SI+D+ I P +I + +N ++
Sbjct: 229 LDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVT 288
Query: 195 LRFLRALRLLELPQILQILR----AIKTSNSVKFSKLLSIILSTWFTAAGFIHLVENSGD 250
LR R R+ + + Q LR +K+ S L S+ ++ A + + S
Sbjct: 289 LRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSA 348
Query: 251 PWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANYIPE 310
S+ S S + + T +T+G+GD+V KT G+ F +L +++ A +P
Sbjct: 349 -------SKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPV 401
Query: 311 MVELFA 316
+V F+
Sbjct: 402 IVSNFS 407
>gi|27436988 potassium voltage-gated channel, subfamily G, member 1
[Homo sapiens]
Length = 513
Score = 52.0 bits (123), Expect = 3e-06
Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 28/236 (11%)
Query: 104 VLVILVFVLSIGSLIIYFINSADPVGSCSSYEDKTIPIDLVFNAFFSFYFGLRFMAADDK 163
VL + V +++ + + + G CS ++ V +FS F LR + A K
Sbjct: 234 VLFVTVTAVNLSVSTLPSLREEEEQGHCSQMCHNVFIVESVCVGWFSLEFLLRLIQAPSK 293
Query: 164 IKFWLEMNSIVDIFTIPPTFISY-----------------YLKSNWLGLRFLRALRLLEL 206
F +++D+ I P +I+ YL L LR LRALR+L +
Sbjct: 294 FAFLRSPLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRALRILYV 353
Query: 207 PQI------LQILRAIKTSNSVKFSKLLSIILSTWFTAAGFIHLVENSGDPWLKGRNSQN 260
++ LQ L + +F LL + A ++++EN + +
Sbjct: 354 MRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENE-----MADSPEF 408
Query: 261 ISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANYIPEMVELFA 316
S + + T +TVG+GD+V +++ G+ + L ++L A + + F+
Sbjct: 409 TSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFS 464
>gi|9789987 potassium voltage-gated channel, Shal-related subfamily,
member 2 [Homo sapiens]
Length = 630
Score = 50.1 bits (118), Expect = 1e-05
Identities = 44/186 (23%), Positives = 81/186 (43%), Gaps = 17/186 (9%)
Query: 141 IDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPPTFISYYLKSN------WLG 194
+D F+ + LR AA + +F + SI+D+ I P +I + N ++
Sbjct: 232 LDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVT 291
Query: 195 LRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAGFIHLVENSGDPWLK 254
LR R R+ + + Q LR + + S+L ++ S F ++
Sbjct: 292 LRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVM-------FY 344
Query: 255 GRNSQNISYFESI----YLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANYIPE 310
+ S F SI + + T +T+G+GD+V KT G+ F +L +++ A +P
Sbjct: 345 AEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPV 404
Query: 311 MVELFA 316
+V F+
Sbjct: 405 IVSNFS 410
>gi|4826782 potassium voltage-gated channel, shaker-related
subfamily, member 2 [Homo sapiens]
Length = 499
Score = 50.1 bits (118), Expect = 1e-05
Identities = 49/217 (22%), Positives = 92/217 (42%), Gaps = 16/217 (7%)
Query: 115 GSLIIYFINSADPVG--SCSSYEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNS 172
GS + + S +G +S+ D ++ + +FSF F +RF A K F+ + +
Sbjct: 197 GSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMN 256
Query: 173 IVDIFTIPPTFISYYLK-----------SNWLGLRFLRALRLLELPQILQILR---AIKT 218
I+DI I P FI+ + + L LR +RL+ + +I ++ R ++
Sbjct: 257 IIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQI 316
Query: 219 SNSVKFSKLLSIILSTWFTAAGFIHLVENSGDPWLKGRNSQNISYFESIYLVMATTSTVG 278
+ + + L +F G I R SQ S ++ + + + +TVG
Sbjct: 317 LGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVG 376
Query: 279 FGDVVAKTSLGRTFIMFFTLGSLILFANYIPEMVELF 315
+GD+V T G+ + ++ A +P +V F
Sbjct: 377 YGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNF 413
>gi|27436981 potassium voltage-gated channel, Shal-related
subfamily, member 1 [Homo sapiens]
Length = 647
Score = 49.3 bits (116), Expect = 2e-05
Identities = 41/175 (23%), Positives = 80/175 (45%), Gaps = 11/175 (6%)
Query: 149 FSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPPTFISYYLKSN------WLGLRFLRALR 202
F+ + LR AA + +F + S++D+ I P +I + N ++ LR R R
Sbjct: 242 FTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVTLRVFRVFR 301
Query: 203 LLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAGFIHLVENSGDPWLKGRNSQNIS 262
+ + + Q LR + + S+L ++ S F ++ + KG N N +
Sbjct: 302 IFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAE----KGTNKTNFT 357
Query: 263 YFESIY-LVMATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANYIPEMVELFA 316
+ + + T +T+G+GD+V T G+ F +L +++ A +P +V F+
Sbjct: 358 SIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFS 412
>gi|32479527 potassium voltage-gated channel, KQT-like subfamily,
member 1 isoform 1 [Homo sapiens]
Length = 676
Score = 47.8 bits (112), Expect = 6e-05
Identities = 55/257 (21%), Positives = 117/257 (45%), Gaps = 40/257 (15%)
Query: 73 IARSHVRSLHFQGQFRDHIEMLLSAQTFVGQVLVILVFVLSIGSLIIYFINSADPVGSCS 132
+AR+HV QG+ + +E + FV V L+ ++ + ++ I + + +
Sbjct: 101 LARTHV-----QGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGT 155
Query: 133 SYEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKF---WLEMN------SIVDIFTIPPTF 183
+ +++V FF + +R +A + K+ W + SI+D+ + +
Sbjct: 156 LFW-----MEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASM 210
Query: 184 I--------SYYLKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTW 235
+ + S G+RFL+ LR+L + + R + SV F +I + +
Sbjct: 211 VVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLL---GSVVFIHRQELITTLY 267
Query: 236 FTAAGFIHLVENSGDPWLKGRNSQNIS-------YFESIYLVMATTSTVGFGDVVAKTSL 288
GF+ L+ +S +L +++ N S Y ++++ + T +T+G+GD V +T +
Sbjct: 268 I---GFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWV 324
Query: 289 GRTFIMFFTLGSLILFA 305
G+T F++ ++ FA
Sbjct: 325 GKTIASCFSVFAISFFA 341
>gi|45383011 potassium voltage-gated channel, delayed-rectifier,
subfamily S, member 2 [Homo sapiens]
Length = 477
Score = 47.8 bits (112), Expect = 6e-05
Identities = 58/233 (24%), Positives = 102/233 (43%), Gaps = 38/233 (16%)
Query: 85 GQFRDHIEMLLS--AQTFVGQVLVILVFVLSIGSLIIYFINSAD----PVGSCSSYEDKT 138
G FR + + L + + +V IL ++ +GS+I +NS P + ED
Sbjct: 167 GNFRRQLWLALDNPGYSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNPGEDPR 226
Query: 139 IPIDLVFN-AFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPPTFISYYLK-------- 189
I F A+F+F RF A D +KF+ +++D+ +I P +I+ +
Sbjct: 227 FEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPT 286
Query: 190 -SNWLG-----LRFLRALRLLELPQILQILRAIKTSNSVKFSKL------LSIILSTWFT 237
+N LG LR +R R+L+L + LR++ + + ++ LS+ +S +
Sbjct: 287 LAN-LGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSV 345
Query: 238 AAGFIHLVENSGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGR 290
A I EN G + + + +TVG+GDVV T+ G+
Sbjct: 346 VAYTIEKEENEGLATIPA----------CWWWATVSMTTVGYGDVVPGTTAGK 388
>gi|5031819 potassium voltage-gated channel, shaker-related
subfamily, member 10 [Homo sapiens]
Length = 511
Score = 47.0 bits (110), Expect = 1e-04
Identities = 46/207 (22%), Positives = 90/207 (43%), Gaps = 14/207 (6%)
Query: 122 INSADPVGSCSSYEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPP 181
+N + V S + + D ++ +F+F LRF+ K F+ + +I+DI +I P
Sbjct: 255 LNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIP 314
Query: 182 ---TFISYYLKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTA 238
T I+ ++ + +L +L + +++++ R K S K ++L L
Sbjct: 315 YFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRE 374
Query: 239 AG------FIHLVENSGDPWLKGRNSQNISYFESI----YLVMATTSTVGFGDVVAKTSL 288
G FI ++ S + + S+F SI + + T +TVG+GD+ T
Sbjct: 375 LGLLIFFLFIGVILFSSAVYF-AEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPG 433
Query: 289 GRTFIMFFTLGSLILFANYIPEMVELF 315
G+ + ++ A +P +V F
Sbjct: 434 GKIVGTLCAIAGVLTIALPVPVIVSNF 460
>gi|20070166 potassium voltage-gated channel, subfamily F, member 1
[Homo sapiens]
Length = 494
Score = 47.0 bits (110), Expect = 1e-04
Identities = 52/230 (22%), Positives = 100/230 (43%), Gaps = 19/230 (8%)
Query: 103 QVLVILVFVLSIGSLIIYFINSADPV----GSCSSYEDKTIP-IDLVFNAFFSFYFGLRF 157
+V+ +L F+L + S ++ + + + + E T+ ++ +F+ + LR
Sbjct: 182 RVVAVLSFLLILVSSVVMCMGTIPELQVLDAEGNRVEHPTLENVETACIGWFTLEYLLRL 241
Query: 158 MAADDKIKFWLEMNSIVDIFTIPPTFISYYLKSNWLGLRFLRALRLLELPQILQILRAIK 217
++ +K+ F L +IVD+ I P ++S L LG R + + + Q L+I+R +
Sbjct: 242 FSSPNKLHFALSFMNIVDVLAILPFYVSLTLTH--LGARMMELTNVQQAVQALRIMRIAR 299
Query: 218 TSNSVKFS---KLLSIILSTWFTAAGFIHLVENSGDPWLKG-----RNSQNISYFESI-- 267
+ S + L+ L F G + + G S + F+SI
Sbjct: 300 IFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIPQ 359
Query: 268 --YLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANYIPEMVELF 315
+ + T +TVG+GD+ KT+LG+ L +I A I ++ F
Sbjct: 360 SFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNF 409
>gi|24497460 Shaw-related voltage-gated potassium channel protein 3
[Homo sapiens]
Length = 757
Score = 46.6 bits (109), Expect = 1e-04
Identities = 57/232 (24%), Positives = 100/232 (43%), Gaps = 31/232 (13%)
Query: 127 PVGSCSSYEDKTIP----IDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPPT 182
P + ++ E +T P ++ V +F+F F +R DK++F +I+D I P
Sbjct: 333 PPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPF 392
Query: 183 FISYYLKS-------NWLG----LRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSII 231
++ L + LG +RF+R LR+ +L + LR + + ++ L +I
Sbjct: 393 YLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLI 452
Query: 232 LSTWFTAAG------FIHLVENSG-DPWLKGRNSQNISYFESI----YLVMATTSTVGFG 280
+ F A G I+ E G DP N +YF++I + + T +T+G+G
Sbjct: 453 I---FLALGVLIFATMIYYAERIGADP--DDILGSNHTYFKNIPIGFWWAVVTMTTLGYG 507
Query: 281 DVVAKTSLGRTFIMFFTLGSLILFANYIPEMVELFANKRKYTSSYEALKGKK 332
D+ KT G L ++ A +P +V F + + L KK
Sbjct: 508 DMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKK 559
>gi|32479525 potassium voltage-gated channel, KQT-like subfamily,
member 1 isoform 2 [Homo sapiens]
Length = 549
Score = 44.7 bits (104), Expect = 5e-04
Identities = 43/189 (22%), Positives = 89/189 (47%), Gaps = 30/189 (15%)
Query: 141 IDLVFNAFFSFYFGLRFMAADDKIKF---WLEMN------SIVDIFTIPPTFI------- 184
+++V FF + +R +A + K+ W + SI+D+ + + +
Sbjct: 32 MEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSK 91
Query: 185 -SYYLKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAGFIH 243
+ S G+RFL+ LR+L + + R + SV F +I + + GF+
Sbjct: 92 GQVFATSAIRGIRFLQILRMLHVDRQGGTWRLL---GSVVFIHRQELITTLYI---GFLG 145
Query: 244 LVENSGDPWLKGRNSQNIS-------YFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFF 296
L+ +S +L +++ N S Y ++++ + T +T+G+GD V +T +G+T F
Sbjct: 146 LIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCF 205
Query: 297 TLGSLILFA 305
++ ++ FA
Sbjct: 206 SVFAISFFA 214
>gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]
Length = 500
Score = 44.7 bits (104), Expect = 5e-04
Identities = 49/209 (23%), Positives = 98/209 (46%), Gaps = 15/209 (7%)
Query: 111 VLSIGSLIIYFINSADPVGSCSSYEDKTIPI-DLVFNAFFSFYFGLRFMAADDKIKFWLE 169
V+SI +++ IN A S + + + I + V ++F+ F LRF+ D+ +F +
Sbjct: 214 VISIIFVVVSIINMALMSAELSWLDLQLLEILEYVCISWFTGEFVLRFLCVRDRCRFLRK 273
Query: 170 MNSIVDIFTIPPTFISYYLKSNWLGLRFLRAL----RLLELPQILQILRAIKTSNSVKFS 225
+ +I+D+ I P +I+ ++S G + + L R++++ ++L+ LR +K
Sbjct: 274 VPNIIDLLAILPFYITLLVES-LSGSQTTQELENVGRIVQVLRLLRALRMLKLGRHSTGL 332
Query: 226 KLLSIILSTWFTAAGFIHLVENSGDPWLK-----GRNSQNISYFESIYLV--MATTS--T 276
+ L + ++ + G + L + G S + F S+ ATTS T
Sbjct: 333 RSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTTFTSVPCAWWWATTSMTT 392
Query: 277 VGFGDVVAKTSLGRTFIMFFTLGSLILFA 305
VG+GD+ T+ G+ L +++ A
Sbjct: 393 VGYGDIRPDTTTGKIVAFMCILSGILVLA 421
>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
[Homo sapiens]
Length = 1017
Score = 43.5 bits (101), Expect = 0.001
Identities = 38/164 (23%), Positives = 74/164 (45%), Gaps = 29/164 (17%)
Query: 195 LRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSI--ILSTWFTAAGFI--HLVENSGD 250
+ L+ +RLL L ++LQ L ++V + L+S+ +L+ W ++ + D
Sbjct: 333 VHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEAND 392
Query: 251 P------WLK---------------GRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLG 289
P WL G S+ +Y ++Y +++ ++VGFG+V A T
Sbjct: 393 PLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAE 452
Query: 290 RTF-IMFFTLGSL---ILFANYIPEMVELFANKRKYTSSYEALK 329
+ F I +G+L ++F N + +++ + Y S + LK
Sbjct: 453 KIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLK 496
>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
isoform 2 [Homo sapiens]
Length = 962
Score = 43.5 bits (101), Expect = 0.001
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 4/78 (5%)
Query: 248 SGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTF-IMFFTLGSLI---L 303
SG +G S+N Y S+Y M + ++VGFG++ T + + F + +GSL+ +
Sbjct: 408 SGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATI 467
Query: 304 FANYIPEMVELFANKRKY 321
F N +++AN +Y
Sbjct: 468 FGNVTTIFQQMYANTNRY 485
>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
isoform 1 [Homo sapiens]
Length = 989
Score = 43.5 bits (101), Expect = 0.001
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 4/78 (5%)
Query: 248 SGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTF-IMFFTLGSLI---L 303
SG +G S+N Y S+Y M + ++VGFG++ T + + F + +GSL+ +
Sbjct: 435 SGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATI 494
Query: 304 FANYIPEMVELFANKRKY 321
F N +++AN +Y
Sbjct: 495 FGNVTTIFQQMYANTNRY 512
>gi|88758565 potassium voltage-gated channel, shaker-related
subfamily, member 3 [Homo sapiens]
Length = 575
Score = 42.7 bits (99), Expect = 0.002
Identities = 42/195 (21%), Positives = 82/195 (42%), Gaps = 11/195 (5%)
Query: 132 SSYEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPPTFISY--YLK 189
SS+ D ++ + +FSF +RF A K F + +++DI I P FI+ L
Sbjct: 289 SSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELA 348
Query: 190 SNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAG------FIH 243
+ +L +L + +++++ R K S K ++L L G FI
Sbjct: 349 ERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIG 408
Query: 244 LVENSGDPWLKGRNSQNISYF---ESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGS 300
++ S + + + ++ + + T +TVG+GD+ T G+ +
Sbjct: 409 VILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAG 468
Query: 301 LILFANYIPEMVELF 315
++ A +P +V F
Sbjct: 469 VLTIALPVPVIVSNF 483
>gi|19424136 potassium channel, subfamily V, member 2 [Homo sapiens]
Length = 545
Score = 42.4 bits (98), Expect = 0.003
Identities = 50/219 (22%), Positives = 94/219 (42%), Gaps = 35/219 (15%)
Query: 141 IDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPPTFISYYL---------KSN 191
++++ FF+ + LR + D +F ++VD+ I P ++ L +
Sbjct: 305 VEMLCMGFFTLEYLLRLASTPDLRRFARSALNLVDLVAILPLYLQLLLECFTGEGHQRGQ 364
Query: 192 WLGL-----RFLRALRLLELPQILQILRAIKTSNSVKFSK---------LLSIILSTWFT 237
+G + LR +RL+ + +IL++ R + F+ LL I FT
Sbjct: 365 TVGSVGKVGQVLRVMRLMRIFRILKLARHSTGLRAFGFTLRQCYQQVGCLLLFIAMGIFT 424
Query: 238 AAGFIHLVENSGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFT 297
+ ++ VE+ + N I + S + + STVG+GD+ +T LGR F
Sbjct: 425 FSAAVYSVEHD----VPSTNFTTIPH--SWWWAAVSISTVGYGDMYPETHLGRFFAFLCI 478
Query: 298 LGSLILFANYIPEMVELFANKRKYTSSYEALKGKKFIVV 336
+IL N +P + + N K++ Y LK ++ +
Sbjct: 479 AFGIIL--NGMP--ISILYN--KFSDYYSKLKAYEYTTI 511
>gi|26051268 potassium voltage-gated channel KQT-like protein 2
isoform e [Homo sapiens]
Length = 393
Score = 42.4 bits (98), Expect = 0.003
Identities = 52/211 (24%), Positives = 100/211 (47%), Gaps = 14/211 (6%)
Query: 104 VLVILVFVLSIGSLIIYFINSADPVGSCSSYEDKTIPIDLV--FNAFFSFYFGLRFMAAD 161
+LV VLS+ S I + S++ G+ E TI + V F ++ R+
Sbjct: 101 LLVFSCLVLSVFSTIKEYEKSSE--GALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWR 158
Query: 162 DKIKFWLEMNSIVDIFTIPPTF--ISYYLKSNWLGLRFLRALRLLELPQILQILR---AI 216
++KF + ++DI + + ++ + N LR+LR L++ +++++ R
Sbjct: 159 GRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTW 218
Query: 217 KTSNSVKFSKLLSIILSTWFTAAGFIHLVENSGDPWL--KGRNSQNISYFESIYLVMATT 274
K SV ++ ++ + W+ GF+ L+ S +L KG N +Y ++++ + T
Sbjct: 219 KLLGSVVYAHSKELV-TAWYI--GFLCLILASFLVYLAEKGENDHFDTYADALWWGLITL 275
Query: 275 STVGFGDVVAKTSLGRTFIMFFTLGSLILFA 305
+T+G+GD +T GR FTL + FA
Sbjct: 276 TTIGYGDKYPQTWNGRLLAATFTLIGVSFFA 306
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,307,435
Number of Sequences: 37866
Number of extensions: 1831817
Number of successful extensions: 4564
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 4414
Number of HSP's gapped (non-prelim): 125
length of query: 1149
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1036
effective length of database: 13,968,660
effective search space: 14471531760
effective search space used: 14471531760
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.