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Search of human proteins with 109637763
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109637763 calpastatin isoform h [Homo sapiens]
(769 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109637763 calpastatin isoform h [Homo sapiens] 1516 0.0
gi|109637753 calpastatin isoform a [Homo sapiens] 1504 0.0
gi|109637757 calpastatin isoform e [Homo sapiens] 1481 0.0
gi|109637759 calpastatin isoform f [Homo sapiens] 1467 0.0
gi|109637761 calpastatin isoform g [Homo sapiens] 1457 0.0
gi|27765085 calpastatin isoform b [Homo sapiens] 1360 0.0
gi|109637765 calpastatin isoform i [Homo sapiens] 1347 0.0
gi|109637769 calpastatin isoform k [Homo sapiens] 1324 0.0
gi|109637767 calpastatin isoform j [Homo sapiens] 1310 0.0
gi|109637771 calpastatin isoform l [Homo sapiens] 1274 0.0
gi|27765087 calpastatin isoform c [Homo sapiens] 781 0.0
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 91 3e-18
gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa... 73 9e-13
gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa... 73 9e-13
gi|150170670 piccolo isoform 2 [Homo sapiens] 73 1e-12
gi|150378539 piccolo isoform 1 [Homo sapiens] 73 1e-12
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens] 72 3e-12
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 67 6e-11
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 67 6e-11
gi|104526627 triadin [Homo sapiens] 67 8e-11
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 65 3e-10
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 64 4e-10
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 64 4e-10
gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 64 4e-10
gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 64 4e-10
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 64 4e-10
gi|109637791 transcription factor-like nuclear regulator [Homo s... 64 5e-10
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 64 7e-10
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 64 7e-10
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ... 62 2e-09
>gi|109637763 calpastatin isoform h [Homo sapiens]
Length = 769
Score = 1516 bits (3926), Expect = 0.0
Identities = 769/769 (100%), Positives = 769/769 (100%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE
Sbjct: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA
Sbjct: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
Query: 181 ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 240
ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG
Sbjct: 181 ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 240
Query: 241 PEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDF 300
PEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDF
Sbjct: 241 PEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDF 300
Query: 301 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG 360
TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG
Sbjct: 301 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG 360
Query: 361 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 420
TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK
Sbjct: 361 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 420
Query: 421 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 480
PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP
Sbjct: 421 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 480
Query: 481 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 540
PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP
Sbjct: 481 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 540
Query: 541 DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 600
DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI
Sbjct: 541 DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 600
Query: 601 SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA 660
SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA
Sbjct: 601 SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA 660
Query: 661 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 720
KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD
Sbjct: 661 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 720
Query: 721 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 769
SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 721 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 769
>gi|109637753 calpastatin isoform a [Homo sapiens]
Length = 791
Score = 1504 bits (3893), Expect = 0.0
Identities = 769/791 (97%), Positives = 769/791 (97%), Gaps = 22/791 (2%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKA----------------------VKTEPEK 98
YAGGTASATKVSASSGATSKSSSMNPTETKA VKTEPEK
Sbjct: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK 120
Query: 99 KSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKST 158
KSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKST
Sbjct: 121 KSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKST 180
Query: 159 EPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAAL 218
EPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAAL
Sbjct: 181 EPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAAL 240
Query: 219 DDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITG 278
DDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITG
Sbjct: 241 DDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITG 300
Query: 279 PPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEK 338
PPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEK
Sbjct: 301 PPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEK 360
Query: 339 KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPS 398
KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPS
Sbjct: 361 KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPS 420
Query: 399 EYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKA 458
EYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKA
Sbjct: 421 EYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKA 480
Query: 459 AAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK 518
AAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK
Sbjct: 481 AAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK 540
Query: 519 VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE 578
VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE
Sbjct: 541 VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE 600
Query: 579 DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDS 638
DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDS
Sbjct: 601 DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDS 660
Query: 639 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK 698
LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK
Sbjct: 661 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK 720
Query: 699 SEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAK 758
SEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAK
Sbjct: 721 SEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAK 780
Query: 759 TTEETSKPKDD 769
TTEETSKPKDD
Sbjct: 781 TTEETSKPKDD 791
>gi|109637757 calpastatin isoform e [Homo sapiens]
Length = 756
Score = 1481 bits (3834), Expect = 0.0
Identities = 756/769 (98%), Positives = 756/769 (98%), Gaps = 13/769 (1%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE
Sbjct: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA
Sbjct: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
Query: 181 ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 240
ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG
Sbjct: 181 ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 240
Query: 241 PEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDF 300
PEVSDPMSSTYIEELGKREVTIPPKYRELLAK PIGPDDAIDALSSDF
Sbjct: 241 PEVSDPMSSTYIEELGKREVTIPPKYRELLAK-------------PIGPDDAIDALSSDF 287
Query: 301 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG 360
TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG
Sbjct: 288 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG 347
Query: 361 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 420
TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK
Sbjct: 348 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 407
Query: 421 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 480
PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP
Sbjct: 408 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 467
Query: 481 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 540
PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP
Sbjct: 468 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 527
Query: 541 DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 600
DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI
Sbjct: 528 DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 587
Query: 601 SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA 660
SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA
Sbjct: 588 SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA 647
Query: 661 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 720
KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD
Sbjct: 648 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 707
Query: 721 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 769
SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 708 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 756
>gi|109637759 calpastatin isoform f [Homo sapiens]
Length = 750
Score = 1467 bits (3797), Expect = 0.0
Identities = 750/769 (97%), Positives = 750/769 (97%), Gaps = 19/769 (2%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTK
Sbjct: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTK---------------- 104
Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA
Sbjct: 105 ---PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 161
Query: 181 ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 240
ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG
Sbjct: 162 ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 221
Query: 241 PEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDF 300
PEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDF
Sbjct: 222 PEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDF 281
Query: 301 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG 360
TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG
Sbjct: 282 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG 341
Query: 361 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 420
TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK
Sbjct: 342 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 401
Query: 421 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 480
PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP
Sbjct: 402 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 461
Query: 481 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 540
PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP
Sbjct: 462 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 521
Query: 541 DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 600
DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI
Sbjct: 522 DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 581
Query: 601 SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA 660
SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA
Sbjct: 582 SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA 641
Query: 661 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 720
KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD
Sbjct: 642 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 701
Query: 721 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 769
SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 702 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 750
>gi|109637761 calpastatin isoform g [Homo sapiens]
Length = 772
Score = 1457 bits (3771), Expect = 0.0
Identities = 742/772 (96%), Positives = 750/772 (97%), Gaps = 3/772 (0%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEK---KSQEGK 117
YAGGTASATKVSASSGATSKSSSMNPTETKA+ + + H+K K++ K
Sbjct: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK 120
Query: 118 PKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 177
+ T+PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG
Sbjct: 121 KSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 180
Query: 178 ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT 237
ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT
Sbjct: 181 ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT 240
Query: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS 297
YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS
Sbjct: 241 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS 300
Query: 298 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA 357
SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA
Sbjct: 301 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA 360
Query: 358 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 417
SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP
Sbjct: 361 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 420
Query: 418 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 477
EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ
Sbjct: 421 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 480
Query: 478 SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET 537
SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET
Sbjct: 481 SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET 540
Query: 538 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA 597
IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA
Sbjct: 541 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA 600
Query: 598 AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK 657
AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK
Sbjct: 601 AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK 660
Query: 658 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 717
EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG
Sbjct: 661 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 720
Query: 718 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 769
DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 721 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 772
>gi|27765085 calpastatin isoform b [Homo sapiens]
Length = 686
Score = 1360 bits (3519), Expect = 0.0
Identities = 686/686 (100%), Positives = 686/686 (100%)
Query: 84 MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 143
MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK
Sbjct: 1 MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60
Query: 144 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 203
AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 61 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
Query: 204 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 263
KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180
Query: 264 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 323
PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 181 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 240
Query: 324 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 383
QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 241 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 300
Query: 384 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 443
EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 301 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 360
Query: 444 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 503
EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 361 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 420
Query: 504 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 563
KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 421 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 480
Query: 564 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 623
LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 481 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 540
Query: 624 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 683
SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 541 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 600
Query: 684 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 743
DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 601 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 660
Query: 744 SKAPKNGGKAKDSAKTTEETSKPKDD 769
SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 661 SKAPKNGGKAKDSAKTTEETSKPKDD 686
Score = 223 bits (567), Expect = 7e-58
Identities = 196/672 (29%), Positives = 322/672 (47%), Gaps = 63/672 (9%)
Query: 3 QPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYA 62
+P + P++A+ H + S S + +K ++ K S + A
Sbjct: 34 KPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVA 93
Query: 63 GGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKL-SVVHEKKSQEGKPKE- 120
G TA +S G K + T V+++P+K S + + + + + G P+E
Sbjct: 94 GITA----ISGKPG-DKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEET 148
Query: 121 ------HTEPKSLPKQAS----DTGSNDA-----HNKKAVSRSAEQQPSEKSTEPKTKPQ 165
+T P+ +S + G + + + + P S++P P
Sbjct: 149 EEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP-IGPD 207
Query: 166 DMISA-GGESVAGITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDA 216
D I A + G +GK +K++ + ++ A P + K K + D
Sbjct: 208 DAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQ 267
Query: 217 ALDDLIDTLGGPEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR-ELLAKKE 274
AL+ L +L G + E E + EV + + +E+ G+ + TIP +YR + K+
Sbjct: 268 ALEALSASL-GTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKD 326
Query: 275 G--ITGPPADSSKPIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLK 322
G + P + KP + ID LS DF P+ +KTE+ ++ +E +
Sbjct: 327 GKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVC 386
Query: 323 AQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAK 382
S +++SA P + K T+ D A+EAL+ SLG ++A+PE D + + + + KAK
Sbjct: 387 RTSMCSIQSAPP----EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAK 441
Query: 383 EEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSE 441
EE EK GE +ETIP +YRL+ DKDGKPLLP E +E+ P SE L+D LSEDF +
Sbjct: 442 EEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ 501
Query: 442 CKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALAD 500
+ + K E++K A A +SE V +T + Q+ APP + DDA++ L+D
Sbjct: 502 -----NASSLKFEDAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSD 554
Query: 501 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--K 558
SLG+++ DP++ KP+ DKVKEKAK E R+KLGE+++TIPP+YR + KP+ P K
Sbjct: 555 SLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTK 614
Query: 559 ESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPP 618
+S++ P + +DALS D + + AK + S+ P + +A
Sbjct: 615 KSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSA 674
Query: 619 RDTSQSDKDLDD 630
+ T ++ K DD
Sbjct: 675 KTTEETSKPKDD 686
Score = 89.4 bits (220), Expect = 1e-17
Identities = 87/359 (24%), Positives = 148/359 (41%), Gaps = 17/359 (4%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
+ +P +KP PR + + + E PSKP EK + A + S RT
Sbjct: 331 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 388
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
SA A+ T ++ K E + + + V EK +E + K
Sbjct: 389 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 448
Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
+ +++P D K + + +++Q S + +G ++ + +
Sbjct: 449 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 508
Query: 181 ISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEENTT 237
K E S TPA ++ P + + +S +D ALD L D+LG + +EN
Sbjct: 509 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKP 568
Query: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIGPDD 291
+V + + + ++LG+R+ TIPP+YR LL ++ PP DS KP D
Sbjct: 569 ME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 627
Query: 292 AIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 345
IDALS D +C S T + T K++ + + A G + +A E+ K + D
Sbjct: 628 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 686
>gi|109637765 calpastatin isoform i [Homo sapiens]
Length = 708
Score = 1347 bits (3486), Expect = 0.0
Identities = 686/708 (96%), Positives = 686/708 (96%), Gaps = 22/708 (3%)
Query: 84 MNPTETKA----------------------VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 121
MNPTETKA VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH
Sbjct: 1 MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60
Query: 122 TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 181
TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 61 TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 120
Query: 182 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 241
SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 121 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180
Query: 242 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 301
EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT
Sbjct: 181 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240
Query: 302 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 361
CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 241 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300
Query: 362 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 421
RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 301 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360
Query: 422 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 481
KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 361 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420
Query: 482 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 541
EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 421 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480
Query: 542 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 601
YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 481 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 540
Query: 602 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 661
EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 541 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 600
Query: 662 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 721
AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 601 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660
Query: 722 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 769
CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 661 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708
Score = 223 bits (567), Expect = 7e-58
Identities = 196/672 (29%), Positives = 322/672 (47%), Gaps = 63/672 (9%)
Query: 3 QPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYA 62
+P + P++A+ H + S S + +K ++ K S + A
Sbjct: 56 KPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVA 115
Query: 63 GGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKL-SVVHEKKSQEGKPKE- 120
G TA +S G K + T V+++P+K S + + + + + G P+E
Sbjct: 116 GITA----ISGKPG-DKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEET 170
Query: 121 ------HTEPKSLPKQAS----DTGSNDA-----HNKKAVSRSAEQQPSEKSTEPKTKPQ 165
+T P+ +S + G + + + + P S++P P
Sbjct: 171 EEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP-IGPD 229
Query: 166 DMISA-GGESVAGITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDA 216
D I A + G +GK +K++ + ++ A P + K K + D
Sbjct: 230 DAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQ 289
Query: 217 ALDDLIDTLGGPEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR-ELLAKKE 274
AL+ L +L G + E E + EV + + +E+ G+ + TIP +YR + K+
Sbjct: 290 ALEALSASL-GTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKD 348
Query: 275 G--ITGPPADSSKPIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLK 322
G + P + KP + ID LS DF P+ +KTE+ ++ +E +
Sbjct: 349 GKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVC 408
Query: 323 AQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAK 382
S +++SA P + K T+ D A+EAL+ SLG ++A+PE D + + + + KAK
Sbjct: 409 RTSMCSIQSAPP----EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAK 463
Query: 383 EEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSE 441
EE EK GE +ETIP +YRL+ DKDGKPLLP E +E+ P SE L+D LSEDF +
Sbjct: 464 EEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ 523
Query: 442 CKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALAD 500
+ + K E++K A A +SE V +T + Q+ APP + DDA++ L+D
Sbjct: 524 -----NASSLKFEDAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSD 576
Query: 501 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--K 558
SLG+++ DP++ KP+ DKVKEKAK E R+KLGE+++TIPP+YR + KP+ P K
Sbjct: 577 SLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTK 636
Query: 559 ESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPP 618
+S++ P + +DALS D + + AK + S+ P + +A
Sbjct: 637 KSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSA 696
Query: 619 RDTSQSDKDLDD 630
+ T ++ K DD
Sbjct: 697 KTTEETSKPKDD 708
Score = 89.4 bits (220), Expect = 1e-17
Identities = 87/359 (24%), Positives = 148/359 (41%), Gaps = 17/359 (4%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
+ +P +KP PR + + + E PSKP EK + A + S RT
Sbjct: 353 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 410
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
SA A+ T ++ K E + + + V EK +E + K
Sbjct: 411 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 470
Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
+ +++P D K + + +++Q S + +G ++ + +
Sbjct: 471 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 530
Query: 181 ISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEENTT 237
K E S TPA ++ P + + +S +D ALD L D+LG + +EN
Sbjct: 531 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKP 590
Query: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIGPDD 291
+V + + + ++LG+R+ TIPP+YR LL ++ PP DS KP D
Sbjct: 591 ME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 649
Query: 292 AIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 345
IDALS D +C S T + T K++ + + A G + +A E+ K + D
Sbjct: 650 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708
>gi|109637769 calpastatin isoform k [Homo sapiens]
Length = 673
Score = 1324 bits (3427), Expect = 0.0
Identities = 673/686 (98%), Positives = 673/686 (98%), Gaps = 13/686 (1%)
Query: 84 MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 143
MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK
Sbjct: 1 MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60
Query: 144 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 203
AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 61 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
Query: 204 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 263
KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180
Query: 264 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 323
PKYRELLAK PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 181 PKYRELLAK-------------PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 227
Query: 324 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 383
QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 228 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 287
Query: 384 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 443
EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 288 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 347
Query: 444 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 503
EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 348 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 407
Query: 504 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 563
KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 408 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 467
Query: 564 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 623
LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 468 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 527
Query: 624 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 683
SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 528 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 587
Query: 684 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 743
DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 588 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 647
Query: 744 SKAPKNGGKAKDSAKTTEETSKPKDD 769
SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 648 SKAPKNGGKAKDSAKTTEETSKPKDD 673
Score = 224 bits (572), Expect = 2e-58
Identities = 196/659 (29%), Positives = 319/659 (48%), Gaps = 50/659 (7%)
Query: 3 QPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYA 62
+P + P++A+ H + S S + +K ++ K S + A
Sbjct: 34 KPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVA 93
Query: 63 GGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKL-SVVHEKKSQEGKPKEH 121
G TA +S G K + T V+++P+K S + + + + + G P+E
Sbjct: 94 GITA----ISGKPG-DKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEET 148
Query: 122 TEPKS--LPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK-TKPQDMISA-GGESVAG 177
E + + SD S+ + ++ R P + K P D I A + G
Sbjct: 149 EEENTTYTGPEVSDPMSS-TYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCG 207
Query: 178 ITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPE 229
+GK +K++ + ++ A P + K K + D AL+ L +L G
Sbjct: 208 SPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL-GTR 266
Query: 230 ETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR-ELLAKKEG--ITGPPADSSK 285
+ E E + EV + + +E+ G+ + TIP +YR + K+G + P + K
Sbjct: 267 QAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPK 326
Query: 286 PIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLKAQSAGTVRSAAPP 335
P + ID LS DF P+ +KTE+ ++ +E + S +++SA P
Sbjct: 327 PRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP- 385
Query: 336 QEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDET 395
+ K T+ D A+EAL+ SLG ++A+PE D + + + + KAKEE EK GE +ET
Sbjct: 386 ---EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEET 441
Query: 396 IPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE 454
IP +YRL+ DKDGKPLLP E +E+ P SE L+D LSEDF + + + K E
Sbjct: 442 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFE 496
Query: 455 ESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEADPEDGK 513
++K A A +SE V +T + Q+ APP + DDA++ L+DSLG+++ DP++ K
Sbjct: 497 DAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENK 554
Query: 514 PVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDF 571
P+ DKVKEKAK E R+KLGE+++TIPP+YR + KP+ P K+S++ P +
Sbjct: 555 PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 614
Query: 572 LLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 630
+DALS D + + AK + S+ P + +A + T ++ K DD
Sbjct: 615 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 673
Score = 89.4 bits (220), Expect = 1e-17
Identities = 87/359 (24%), Positives = 148/359 (41%), Gaps = 17/359 (4%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
+ +P +KP PR + + + E PSKP EK + A + S RT
Sbjct: 318 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 375
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
SA A+ T ++ K E + + + V EK +E + K
Sbjct: 376 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 435
Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
+ +++P D K + + +++Q S + +G ++ + +
Sbjct: 436 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 495
Query: 181 ISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEENTT 237
K E S TPA ++ P + + +S +D ALD L D+LG + +EN
Sbjct: 496 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKP 555
Query: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIGPDD 291
+V + + + ++LG+R+ TIPP+YR LL ++ PP DS KP D
Sbjct: 556 ME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 614
Query: 292 AIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 345
IDALS D +C S T + T K++ + + A G + +A E+ K + D
Sbjct: 615 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 673
>gi|109637767 calpastatin isoform j [Homo sapiens]
Length = 667
Score = 1310 bits (3390), Expect = 0.0
Identities = 667/686 (97%), Positives = 667/686 (97%), Gaps = 19/686 (2%)
Query: 84 MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 143
MNPTETKAVKTEPEKKSQSTK PKSLPKQASDTGSNDAHNKK
Sbjct: 1 MNPTETKAVKTEPEKKSQSTK-------------------PKSLPKQASDTGSNDAHNKK 41
Query: 144 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 203
AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 42 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 101
Query: 204 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 263
KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 102 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 161
Query: 264 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 323
PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 162 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 221
Query: 324 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 383
QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 222 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 281
Query: 384 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 443
EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 282 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 341
Query: 444 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 503
EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 342 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 401
Query: 504 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 563
KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 402 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 461
Query: 564 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 623
LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 462 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 521
Query: 624 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 683
SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 522 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 581
Query: 684 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 743
DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 582 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 641
Query: 744 SKAPKNGGKAKDSAKTTEETSKPKDD 769
SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 642 SKAPKNGGKAKDSAKTTEETSKPKDD 667
Score = 222 bits (566), Expect = 9e-58
Identities = 195/661 (29%), Positives = 319/661 (48%), Gaps = 63/661 (9%)
Query: 14 PRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSA 73
P++A+ H + S S + +K ++ K S + AG TA +S
Sbjct: 26 PKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA----ISG 81
Query: 74 SSGATSKSSSMNPTETKAVKTEPEKKSQSTKL-SVVHEKKSQEGKPKE-------HTEPK 125
G K + T V+++P+K S + + + + + G P+E +T P+
Sbjct: 82 KPG-DKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPE 140
Query: 126 SLPKQAS----DTGSNDA-----HNKKAVSRSAEQQPSEKSTEPKTKPQDMISA-GGESV 175
+S + G + + + + P S++P P D I A +
Sbjct: 141 VSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP-IGPDDAIDALSSDFT 199
Query: 176 AGITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGG 227
G +GK +K++ + ++ A P + K K + D AL+ L +L G
Sbjct: 200 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL-G 258
Query: 228 PEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR-ELLAKKEG--ITGPPADS 283
+ E E + EV + + +E+ G+ + TIP +YR + K+G + P +
Sbjct: 259 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 318
Query: 284 SKPIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLKAQSAGTVRSAA 333
KP + ID LS DF P+ +KTE+ ++ +E + S +++SA
Sbjct: 319 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 378
Query: 334 PPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDD 393
P + K T+ D A+EAL+ SLG ++A+PE D + + + + KAKEE EK GE +
Sbjct: 379 P----EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKE 433
Query: 394 ETIPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK 452
ETIP +YRL+ DKDGKPLLP E +E+ P SE L+D LSEDF + + + K
Sbjct: 434 ETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLK 488
Query: 453 TEESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEADPED 511
E++K A A +SE V +T + Q+ APP + DDA++ L+DSLG+++ DP++
Sbjct: 489 FEDAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDE 546
Query: 512 GKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSE 569
KP+ DKVKEKAK E R+KLGE+++TIPP+YR + KP+ P K+S++ P +
Sbjct: 547 NKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADD 606
Query: 570 DFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLD 629
+DALS D + + AK + S+ P + +A + T ++ K D
Sbjct: 607 QDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKD 666
Query: 630 D 630
D
Sbjct: 667 D 667
Score = 89.4 bits (220), Expect = 1e-17
Identities = 87/359 (24%), Positives = 148/359 (41%), Gaps = 17/359 (4%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
+ +P +KP PR + + + E PSKP EK + A + S RT
Sbjct: 312 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 369
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
SA A+ T ++ K E + + + V EK +E + K
Sbjct: 370 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 429
Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
+ +++P D K + + +++Q S + +G ++ + +
Sbjct: 430 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 489
Query: 181 ISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEENTT 237
K E S TPA ++ P + + +S +D ALD L D+LG + +EN
Sbjct: 490 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKP 549
Query: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIGPDD 291
+V + + + ++LG+R+ TIPP+YR LL ++ PP DS KP D
Sbjct: 550 ME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 608
Query: 292 AIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 345
IDALS D +C S T + T K++ + + A G + +A E+ K + D
Sbjct: 609 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 667
>gi|109637771 calpastatin isoform l [Homo sapiens]
Length = 654
Score = 1275 bits (3298), Expect = 0.0
Identities = 654/686 (95%), Positives = 654/686 (95%), Gaps = 32/686 (4%)
Query: 84 MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 143
MNPTETKAVKTEPEKKSQSTK PKSLPKQASDTGSNDAHNKK
Sbjct: 1 MNPTETKAVKTEPEKKSQSTK-------------------PKSLPKQASDTGSNDAHNKK 41
Query: 144 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 203
AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 42 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 101
Query: 204 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 263
KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 102 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 161
Query: 264 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 323
PKYRELLAK PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 162 PKYRELLAK-------------PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 208
Query: 324 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 383
QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 209 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 268
Query: 384 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 443
EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 269 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 328
Query: 444 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 503
EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 329 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 388
Query: 504 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 563
KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 389 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 448
Query: 564 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 623
LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 449 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 508
Query: 624 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 683
SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 509 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 568
Query: 684 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 743
DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 569 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 628
Query: 744 SKAPKNGGKAKDSAKTTEETSKPKDD 769
SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 629 SKAPKNGGKAKDSAKTTEETSKPKDD 654
Score = 224 bits (571), Expect = 2e-58
Identities = 195/648 (30%), Positives = 316/648 (48%), Gaps = 50/648 (7%)
Query: 14 PRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSA 73
P++A+ H + S S + +K ++ K S + AG TA +S
Sbjct: 26 PKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA----ISG 81
Query: 74 SSGATSKSSSMNPTETKAVKTEPEKKSQSTKL-SVVHEKKSQEGKPKEHTEPKS--LPKQ 130
G K + T V+++P+K S + + + + + G P+E E + +
Sbjct: 82 KPG-DKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPE 140
Query: 131 ASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK-TKPQDMISA-GGESVAGITAISGKPGDK 188
SD S+ + ++ R P + K P D I A + G +GK +K
Sbjct: 141 VSDPMSS-TYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEK 199
Query: 189 KKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 240
++ + ++ A P + K K + D AL+ L +L G + E E +
Sbjct: 200 EESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL-GTRQAEPELDLRSI 258
Query: 241 PEVSDPMS-STYIEELGKREVTIPPKYR-ELLAKKEG--ITGPPADSSKPIGPDDAIDAL 296
EV + + +E+ G+ + TIP +YR + K+G + P + KP + ID L
Sbjct: 259 KEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDEL 318
Query: 297 SSDFTCG----SPTAAGKKTEKEES------TEVLKAQSAGTVRSAAPPQEKKRKVEKDT 346
S DF P+ +KTE+ ++ +E + S +++SA P + K T
Sbjct: 319 SEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP----EPATLKGT 374
Query: 347 MSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPAT 406
+ D A+EAL+ SLG ++A+PE D + + + + KAKEE EK GE +ETIP +YRL+
Sbjct: 375 VPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVK 433
Query: 407 DKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVS 465
DKDGKPLLP E +E+ P SE L+D LSEDF + + + K E++K A A +S
Sbjct: 434 DKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA--AAIS 486
Query: 466 EAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAK 524
E V +T + Q+ APP + DDA++ L+DSLG+++ DP++ KP+ DKVKEKAK
Sbjct: 487 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 546
Query: 525 EEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSEDFSG 582
E R+KLGE+++TIPP+YR + KP+ P K+S++ P + +DALS D
Sbjct: 547 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 606
Query: 583 PQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 630
+ + AK + S+ P + +A + T ++ K DD
Sbjct: 607 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 654
Score = 89.4 bits (220), Expect = 1e-17
Identities = 87/359 (24%), Positives = 148/359 (41%), Gaps = 17/359 (4%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
+ +P +KP PR + + + E PSKP EK + A + S RT
Sbjct: 299 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 356
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
SA A+ T ++ K E + + + V EK +E + K
Sbjct: 357 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 416
Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
+ +++P D K + + +++Q S + +G ++ + +
Sbjct: 417 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 476
Query: 181 ISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEENTT 237
K E S TPA ++ P + + +S +D ALD L D+LG + +EN
Sbjct: 477 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKP 536
Query: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIGPDD 291
+V + + + ++LG+R+ TIPP+YR LL ++ PP DS KP D
Sbjct: 537 ME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 595
Query: 292 AIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 345
IDALS D +C S T + T K++ + + A G + +A E+ K + D
Sbjct: 596 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 654
>gi|27765087 calpastatin isoform c [Homo sapiens]
Length = 430
Score = 781 bits (2017), Expect = 0.0
Identities = 391/393 (99%), Positives = 392/393 (99%), Gaps = 1/393 (0%)
Query: 377 DEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 436
D+AKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED
Sbjct: 39 DQAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 98
Query: 437 FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 496
FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE
Sbjct: 99 FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 158
Query: 497 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 556
ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL
Sbjct: 159 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 218
Query: 557 PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA 616
PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA
Sbjct: 219 PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA 278
Query: 617 PPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP 676
PPRDTS SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP
Sbjct: 279 PPRDTS-SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP 337
Query: 677 PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK 736
PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK
Sbjct: 338 PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK 397
Query: 737 CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 769
CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 398 CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 430
Score = 206 bits (525), Expect = 5e-53
Identities = 144/396 (36%), Positives = 213/396 (53%), Gaps = 30/396 (7%)
Query: 252 IEELGKREVTIPPKYR-ELLAKKEG--ITGPPADSSKPIGPDDAIDALSSDFTCGSPTAA 308
+E+ G+ + TIP +YR + K+G + P + KP + ID LS DF
Sbjct: 48 LEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSE--CK 105
Query: 309 GKKTEKEESTEVLKAQSAGTVRSA-----------APPQEKKRKVEKDTMSDQALEALSA 357
K ++ E TE KA + V A APP+ K T+ D A+EAL+
Sbjct: 106 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLK---GTVPDDAVEALAD 162
Query: 358 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP-E 416
SLG ++A+PE D + + + + KAKEE EK GE +ETIP +YRL+ DKDGKPLLP E
Sbjct: 163 SLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE 221
Query: 417 PEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSI 476
+E+ P SE L+D LSEDF + + + K E++K A A +SE V +T +
Sbjct: 222 SKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA--AAISEVVSQTPASTT 274
Query: 477 QSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEE 536
Q+ P T DDA++ L+DSLG+++ DP++ KP+ DKVKEKAK E R+KLGE+++
Sbjct: 275 QAGAPPRDTSSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDD 334
Query: 537 TIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDA 594
TIPP+YR + KP+ P K+S++ P + +DALS D + + A
Sbjct: 335 TIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTA 394
Query: 595 KLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 630
K + S+ P + +A + T ++ K DD
Sbjct: 395 KDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 430
Score = 91.3 bits (225), Expect = 3e-18
Identities = 87/358 (24%), Positives = 145/358 (40%), Gaps = 16/358 (4%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
+ +P +KP PR + + + E PSKP EK + A + S RT
Sbjct: 76 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 133
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
SA A+ T ++ K E + + + V EK +E + K
Sbjct: 134 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 193
Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
+ +++P D K + + +++Q S + +G ++ + +
Sbjct: 194 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 253
Query: 181 ISGKPGDKKKEKKSLTPAVPVE--SKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTY 238
K E S TPA + + P S +D ALD L D+LG + +EN
Sbjct: 254 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSSDKDLDDALDKLSDSLGQRQPDPDENKPM 313
Query: 239 TGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIGPDDA 292
+V + + + ++LG+R+ TIPP+YR LL ++ PP DS KP D
Sbjct: 314 E-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDP 372
Query: 293 IDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 345
IDALS D +C S T + T K++ + + A G + +A E+ K + D
Sbjct: 373 IDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 430
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 91.3 bits (225), Expect = 3e-18
Identities = 138/596 (23%), Positives = 225/596 (37%), Gaps = 57/596 (9%)
Query: 197 PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELG 256
P +P S K + + +T+ E+TEE T EV++ EE G
Sbjct: 427 PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVT---EEVTEEEEKEAKEEEG 483
Query: 257 KREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEE 316
K E + E +E PPA+ + P+ +A S A K EKEE
Sbjct: 484 KEEEG--GEEEEAEGGEEETKSPPAEEAA--SPEK--EAKSPVKEEAKSPAEAKSPEKEE 537
Query: 317 STEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEV 376
+ + +S +S A + K K ++A + P + K
Sbjct: 538 AKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKE--EAKSP 595
Query: 377 DEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 436
EAK+ E+ E+ ++ P+E + + + PE+ P E E ++
Sbjct: 596 AEAKSPEKAKSPVKEEAKS-PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKS 654
Query: 437 FDRSECK--EKPSKPTEKTEESKAAAPAPV-SEAVCRTSMCS-IQSAPPEPATLKGTVPD 492
++ E K EK P + +S A +PV +EA S ++ P K V +
Sbjct: 655 PEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKE 714
Query: 493 DAVEA-LADSLGKKEAD-PEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDK 550
+A A S K+EA PE K VKE+AK ++ K EK +T+ +VK
Sbjct: 715 EAKSPEKAKSPVKEEAKTPEKAK---SPVKEEAKSPEKAKSPEKAKTL-------DVKSP 764
Query: 551 DGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAA--------AISE 602
+ K +E++ E + E+ P+ A S EDAK S
Sbjct: 765 EAKTPAKEEARSPADKFPEK-AKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSP 823
Query: 603 VVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA-- 660
V + + PP+ + ++ DS + P + KP ++ KE A
Sbjct: 824 VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883
Query: 661 -----KAEHRDKLGERDDTIP-PEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD--DQDPI 712
K E + + E +P PE ++ P K K+ K+ + ++P
Sbjct: 884 KPKESKVEAKKEEAEDKKKVPTPE---------KEAPAKVEVKEDAKPKEKTEVAKKEPD 934
Query: 713 DALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKT-TEETSKPK 767
DA + + E + K +KA + PK KAK+ KT ++E SKPK
Sbjct: 935 DAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPK 990
Score = 91.3 bits (225), Expect = 3e-18
Identities = 124/566 (21%), Positives = 221/566 (39%), Gaps = 65/566 (11%)
Query: 23 THEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSS 82
T E E+ E+ + G+++ E++ A G ++ A AS K + S K
Sbjct: 467 TEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSP---VKEE 523
Query: 83 SMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNK 142
+ +P E K+ + E E KS + S K + + K E KS K+ + + + +
Sbjct: 524 AKSPAEAKSPEKE-EAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPE 582
Query: 143 KAVSRSAEQ--QPSEKSTEPKTKP--QDMISAGGESVAGITAISGKPGDKKKEKKSLTPA 198
KA S + E+ P+E + K K ++ + E+ + + + P + K +K+ +P
Sbjct: 583 KAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPT 642
Query: 199 VPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKR 258
P+K +A PE+ + P ++ S + K
Sbjct: 643 KEEAKSPEKAKSPEKEEAK---------SPEKAKS-------PVKAEAKSPEKAKSPVKA 686
Query: 259 EVTIPPK----YRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEK 314
E P K +E E P + +K P+ A + + + K E
Sbjct: 687 EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK--SPEKAKSPVKEEAKTPEKAKSPVKEEA 744
Query: 315 EESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIK 374
+ + + A T+ +P + K E + +D+ E + + PE +K
Sbjct: 745 KSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLK 804
Query: 375 EVDEAKAKEEKLEKCGE-----DDETIPSEYRLKPATDK---DGKPLLPEPEEKPKPRSE 426
E +AKA E+++ K E +E P E ++K K + P P+ EEK + E
Sbjct: 805 E--DAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKE 862
Query: 427 SELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATL 486
+ ++ + + +EK EK +ESK A E A
Sbjct: 863 ----EAPKKEAPKPKVEEKKEPAVEKPKESKV-------------------EAKKEEAED 899
Query: 487 KGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIP--PDYRL 544
K VP EA A K++A P++ V K + AK ++ K EK+E P D +
Sbjct: 900 KKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKE 959
Query: 545 EEVKDKDGKPLLPKESKEQLPPMSED 570
E+ K + KP ++KE +S++
Sbjct: 960 EKAKKPEEKPKTEAKAKEDDKTLSKE 985
Score = 89.4 bits (220), Expect = 1e-17
Identities = 148/643 (23%), Positives = 251/643 (39%), Gaps = 85/643 (13%)
Query: 86 PTETKAVKTEPEKK----SQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHN 141
P+ + +K + E+K +S K +V+ E++++E + E + + + G +
Sbjct: 430 PSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGG 489
Query: 142 KKAVSRSAEQQ----PSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTP 197
++ + E++ P+E++ P+ + + + +S A K +K++ K
Sbjct: 490 EEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPA-----EAKSPEKEEAKSPAEV 544
Query: 198 AVPVESK-PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDP--MSSTYIEE 254
P ++K P K KS +A PE+ E ++ EV P S EE
Sbjct: 545 KSPEKAKSPAKEEAKSPPEAK---------SPEKEEAKSPA----EVKSPEKAKSPAKEE 591
Query: 255 LGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDA-LSSDFTCGSPTAA-GKKT 312
P+ + K+E + PA++ P+ + A + S SPT K
Sbjct: 592 AKSPAEAKSPEKAKSPVKEEAKS--PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSP 649
Query: 313 EKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA--EPELDL 370
EK +S E +A+S +S + K + K + +A A ++ PE
Sbjct: 650 EKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAK 709
Query: 371 RSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELI 430
+KE EAK+ E+ E+ +T E P ++ P EK K +++ +
Sbjct: 710 SPVKE--EAKSPEKAKSPVKEEAKT--PEKAKSPVKEEAKSP------EKAKSPEKAKTL 759
Query: 431 DELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTV 490
D S + ++ KE+ P +K E A +PV E V P K +
Sbjct: 760 DVKSPEA-KTPAKEEARSPADKFPEK---AKSPVKEEV------------KSPEKAKSPL 803
Query: 491 PDDAVEALADSLGKKEADP----EDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEE 546
+DA +A + KKE E+ KP KVKE K+ + EK P + EE
Sbjct: 804 KEDA-KAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA-------PATPKTEE 855
Query: 547 VKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQ 606
KD K PK KE P E+ A+ + A + ED K E +
Sbjct: 856 KKDSK-KEEAPK--KEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPT-PEKEAP 911
Query: 607 TPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPM--------EDKVKE 658
+ P T + K+ DDA K +++ E K E+K K
Sbjct: 912 AKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKT 971
Query: 659 KAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSED 701
+AKA+ DK ++ + P + + K KPP K +ED
Sbjct: 972 EAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014
Score = 85.1 bits (209), Expect = 2e-16
Identities = 122/528 (23%), Positives = 208/528 (39%), Gaps = 67/528 (12%)
Query: 266 YRELLAKKEGITG-PPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQ 324
YR+LL +E G P S P G I ++S+ S + E+ T +++ Q
Sbjct: 402 YRKLLEGEECRIGFGPIPFSLPEGLPK-IPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQ 460
Query: 325 SAGT-VRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQ---------AEPELDLRS-I 373
+ T V +E+K E++ ++ E A G + A PE + +S +
Sbjct: 461 TEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPV 520
Query: 374 KEVDE--AKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELID 431
KE + A+AK + E+ E E PA ++ P + EK + +S +E+
Sbjct: 521 KEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEV-- 578
Query: 432 ELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVP 491
S + +S KE+ P E KA +P ++ PA K V
Sbjct: 579 -KSPEKAKSPAKEEAKSPAEAKSPEKAKSP--------------VKEEAKSPAEAKSPVK 623
Query: 492 DDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKD 551
++A K A+ + + KE+AK ++ K EKEE P+ VK +
Sbjct: 624 EEA---------KSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674
Query: 552 GKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAST 611
P K S + S + + E+ P+ A S E+AK V + +
Sbjct: 675 KSPEKAK-SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP 733
Query: 612 TQAGAPPRDTSQSD---------KDLDDALDKLSDSLGQRQPDPDENKPMEDK--VKEKA 660
+A +P ++ ++S K LD + + P + P + K VKE+
Sbjct: 734 EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEV 793
Query: 661 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 720
K+ + K ++D PE + + + VK P K+ E ++ + P A + +
Sbjct: 794 KSPEKAKSPLKEDAKAPE-----KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKA---EEE 845
Query: 721 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKD 768
P+T +T + KD K+ A +AP K K K KPK+
Sbjct: 846 KAPATPKTEEK--KDSKKEEAPKKEAP----KPKVEEKKEPAVEKPKE 887
Score = 75.9 bits (185), Expect = 1e-13
Identities = 99/477 (20%), Positives = 180/477 (37%), Gaps = 47/477 (9%)
Query: 4 PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAG 63
P ++ A SP ++ ++ K+ P + K +++A S ++S
Sbjct: 567 PEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEA 626
Query: 64 GTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQE-GKPKEHT 122
+ + K + + +K + +P + K+ + E K + K V E KS E K
Sbjct: 627 KSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKA 686
Query: 123 EPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAIS 182
E KS K S +KA S E+ S + + K + +S A S
Sbjct: 687 EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKS 746
Query: 183 GKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPE 242
+ ++ K+L P P K +S D PE+ + P
Sbjct: 747 PEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKF----------PEKAKS-------PV 789
Query: 243 VSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP--IGPDDAIDALSSDF 300
+ S + K + P K + KKE + P + KP + + +
Sbjct: 790 KEEVKSPEKAKSPLKEDAKAPEKE---IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEK 846
Query: 301 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG 360
+P KK K+E +A P EK ++ + + ++A +
Sbjct: 847 APATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTP 906
Query: 361 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKP-------- 412
++A +++++ ++AK KE K E ++ + ++ KPA K+ P
Sbjct: 907 EKEAPAKVEVK-----EDAKPKE-KTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE 960
Query: 413 LLPEPEEKPKPRSESELIDE-LSEDFDR---------SECKEKPSKPTEKTEESKAA 459
+PEEKPK ++++ D+ LS++ + S +K SKP EK E KAA
Sbjct: 961 KAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAA 1017
Score = 47.8 bits (112), Expect = 4e-05
Identities = 59/270 (21%), Positives = 103/270 (38%), Gaps = 46/270 (17%)
Query: 511 DGKPVMDKVKE--KAKEEDREKLGEK--------EETIPPDYRLEEVKDKDGKPLLPKES 560
+G P + V K K E++ K+ EK EE EEV +++ K +E
Sbjct: 424 EGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEG 483
Query: 561 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 620
KE+ E E G + S E+A + +A +P ++
Sbjct: 484 KEEEGGEEE--------EAEGGEEETKSPPAEEAA-------------SPEKEAKSPVKE 522
Query: 621 TSQSDKDLDDALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEY 679
++S + + P+ +E K P E K EKAK+ +++ + PE
Sbjct: 523 EAKSPAEA-------------KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK 569
Query: 680 RHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKK 739
P K + E++K PA+ + P A S + S E +++ K++ K
Sbjct: 570 EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAE-AKSPVKEEAKS 628
Query: 740 AASSSKAPKNGGKAKDSAKTTEETSKPKDD 769
A K K+ AK+ E+ P+ +
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658
>gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
sapiens]
Length = 1782
Score = 73.2 bits (178), Expect = 9e-13
Identities = 146/699 (20%), Positives = 267/699 (38%), Gaps = 104/699 (14%)
Query: 28 SEKTSESPSKPGEKK-GSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNP 86
+ + S S + G K G D +KA G + + T G A + + G++S + +P
Sbjct: 692 ARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGT-DGILAGSQEHDPGQGSSSPEQAGSP 750
Query: 87 TETKAVKT--------EPEKKSQSTKLSVVHEKKSQE---GKPKEHTEPKSLPKQASDTG 135
TE + V T P KKS+S KL E+KS++ G EH+ P + P +
Sbjct: 751 TEGEGVSTWESFKRLVTPRKKSKS-KL----EEKSEDSIAGSGVEHSTPDTEPGKEESWV 805
Query: 136 SND----AHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKE 191
S KK EQ P E + D ++ A+ + + ++
Sbjct: 806 SIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQA 865
Query: 192 KKSLT-PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPM--- 247
+KS P ++ K +S + + D EE + ++ V++P+
Sbjct: 866 QKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQV 925
Query: 248 ---SSTYIEELGKREVTI---PPKYRELLAKKEGITGPP--------------ADSSKPI 287
++ EE+ +REV PP E L + G A+++ P+
Sbjct: 926 EAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPL 985
Query: 288 GPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTM 347
G ++ +A +++ T +A + T+ ++TE +A V P E++ + ++ +
Sbjct: 986 GAEEGTEASAAEETTEMVSAVSQLTDSPDTTE--EATPVQEVEGGVPDIEEQERRTQEVL 1043
Query: 348 SDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATD 407
A + S PE L+ ++ EA+ EE+ E G LK TD
Sbjct: 1044 QAVAEKVKEESQLPGTGGPEDVLQPVQRA-EAERPEEQAEASG-----------LKKETD 1091
Query: 408 KDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEA 467
K + E K +P ++ +++ + + E EK + TE E SE
Sbjct: 1092 VVLK--VDAQEAKTEPFTQGKVVGQTT-----PESFEKAPQVTESIES---------SEL 1135
Query: 468 VCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPED----GKPVMDKVKEKA 523
V ++ + ++ +P D+VE DS D G D++ E
Sbjct: 1136 VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIH 1195
Query: 524 KEED----REKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ------LPPMSEDFLL 573
+E + + G + E +P +E + +E+KEQ L ++ +
Sbjct: 1196 EENEVASGTQSGGTEAEAVPAQ---KERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSV 1252
Query: 574 DALS--EDFSGPQNASSLKFEDAK-------LAAAISEVVSQTPASTTQAGAPPRDTSQS 624
+ +S G Q A E K L +I ++ + T+ T ++
Sbjct: 1253 ETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEA 1312
Query: 625 DKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 663
+ DDAL+ S + + P P E + + +EK +AE
Sbjct: 1313 ECKKDDALELQSHA--KSPPSPVEREMVVQVEREKTEAE 1349
Score = 47.8 bits (112), Expect = 4e-05
Identities = 133/710 (18%), Positives = 250/710 (35%), Gaps = 91/710 (12%)
Query: 2 SQPGQKPAASPRPRRAAAARRTHEHVSEKTS-----ESPSKPGEKKGSDEKKAASLGSSQ 56
S+ + ++ +P ++H +S E + GE+K E ++ +
Sbjct: 227 SKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTS 286
Query: 57 SSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEG 116
+ G T +G K+S P E + +E +K+ + K+ + K++
Sbjct: 287 PVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVA 346
Query: 117 KPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESV- 175
K T S AH Q+P+E + EP+ +SA E V
Sbjct: 347 SEKL-------------TASEQAH---------PQEPAESAHEPR------LSAEYEKVE 378
Query: 176 -AGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEE 234
+SG G +++ PA D+ + + + T+ E TEE+
Sbjct: 379 LPSEEQVSGSQGPSEEK-----PAPLATEVFDEKIEVHQEEVVAEVHVSTV--EERTEEQ 431
Query: 235 NTTYTGPEVSDPMSSTYIEELGKREV---TIPPKYRELLAKKEGITGPPADSSKPIGPDD 291
T EV + S EEL + + P + K+ ++G + PD+
Sbjct: 432 KT-----EVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDE 486
Query: 292 AIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQ---------SAGTVRSAAPPQEKKRKV 342
+ LS P + E S E +K Q S G + + Q+ KR
Sbjct: 487 KV--LSK-----PPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGG 539
Query: 343 EKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDE-----TIP 397
+ + + + + E S +E +E E+ L + +D E T
Sbjct: 540 GDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSD 599
Query: 398 SEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESK 457
E + + T + P+++ + SES+ DEL + + S +E EE K
Sbjct: 600 GEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDEL-DKVKSATLSSTESTASEMQEEMK 658
Query: 458 AAAPAP--------VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADP 509
+ P V +V ++ + S+ + + +A+ K +
Sbjct: 659 GSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAG 718
Query: 510 EDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL---PKESKEQLPP 566
+D + D + ++E D + E E V + L K+SK +L
Sbjct: 719 KDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEE 778
Query: 567 MSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDK 626
SED + + + S P + + I + P Q AP D +
Sbjct: 779 KSEDSIAGS-GVEHSTPDTEPGKEESWVSIKKFIPGRRKKRP-DGKQEQAPVEDAGPTGA 836
Query: 627 DLDD----ALDKLS--DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGE 670
+ DD A+ LS D++ + + + + + ++ ++KA E +L E
Sbjct: 837 NEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSE 886
Score = 47.4 bits (111), Expect = 5e-05
Identities = 160/822 (19%), Positives = 298/822 (36%), Gaps = 132/822 (16%)
Query: 8 PAASPRPRRAAAARRTHEHVS--EKTSESPSKPGEKKGSDEKKAASLG-SSQSSRTYAGG 64
P + A+AA T E VS + ++SP E E + Q RT
Sbjct: 984 PLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVL 1043
Query: 65 TASATKVSASS---GATSKSSSMNPTETKAVKTEPEKKSQSTKLS----VVHEKKSQEGK 117
A A KV S G + P + +A PE++++++ L VV + +QE K
Sbjct: 1044 QAVAEKVKEESQLPGTGGPEDVLQPVQ-RAEAERPEEQAEASGLKKETDVVLKVDAQEAK 1102
Query: 118 PKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 177
TEP + K T V+ S E S+E T Q AG +S
Sbjct: 1103 ----TEPFTQGKVVGQTTPESFEKAPQVTESIE------SSELVTTCQAETLAGVKSQEM 1152
Query: 178 ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAA----LDDLIDTLGGPEETEE 233
+ + P + P +S+ D + + DA D++++ EE E
Sbjct: 1153 VMEQAIPPDSVE---------TPTDSETDGSTPVADFDAPGTTQKDEIVEI---HEENEV 1200
Query: 234 ENTTYTGPEVSD---------PMSSTYI-----EELGKREVTIPPKYRE-------LLAK 272
+ T +G ++ P S+++ +E K E T+ +E +L+K
Sbjct: 1201 ASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK 1260
Query: 273 KEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTE---KEESTEVLKAQSAGTV 329
EG + + + L G + K TE K E TE + + +
Sbjct: 1261 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1320
Query: 330 R----SAAPP-----------QEKKRKVEKDTMSDQALEALSASLGTRQAEPEL----DL 370
+ +PP + +K + E ++++ LE +A + + +L ++
Sbjct: 1321 ELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNV 1380
Query: 371 RSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELI 430
I E + E C +E + ++ +++ + + L E+ K E+ I
Sbjct: 1381 PIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSS---EASFTLTAAAEEEKVLGETANI 1437
Query: 431 DELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP-EPATLKGT 489
E E + + + + + E AA P +AV C +S P AT K
Sbjct: 1438 LETGETLEPAGAHLVLEEKSSEKNEDFAAHPG--EDAVPTGPDCQAKSTPVIVSATTKKG 1495
Query: 490 VPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKD 549
+ D SL K ++D D + +VK ED E P+ + E++
Sbjct: 1496 LSSDLEGEKTTSL-KWKSDEVDEQVACQEVKVSVAIEDLE----------PENGILELET 1544
Query: 550 KDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPA 609
K K + ++ + A+ + + A+ + + + A + + SQ
Sbjct: 1545 KSSK-------------LVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAG 1591
Query: 610 STTQA-GAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMED-------------- 654
T+ G P+ ++Q + + A ++ S+S Q D +K M +
Sbjct: 1592 QETEKEGEEPQASAQDETPITSAKEE-SESTAVGQAHSDISKDMSEASEKTMTVEVEGST 1650
Query: 655 ----KVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 710
+++E + G ++P + H L +K + P K ++ DD +
Sbjct: 1651 VNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEP--KEDEKGDDVDDPE 1708
Query: 711 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGK 752
++ D D+ T+ S +T K K+ + + GK
Sbjct: 1709 NQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGK 1750
Score = 43.5 bits (101), Expect = 7e-04
Identities = 168/879 (19%), Positives = 313/879 (35%), Gaps = 174/879 (19%)
Query: 8 PAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGS-SQSSRTYAGGTA 66
PA P A R E +++ +S +P +K ++ K S + A GT
Sbjct: 844 PAVVPLSEYDAVEREKME--AQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTR 901
Query: 67 SATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKS 126
+AT + S + +S P E + E ++ V+ + E +P TEP
Sbjct: 902 AATIIEERSPSWISASVTEPLE------QVEAEAALLTEEVLEREVIAEEEPPTVTEPLP 955
Query: 127 LPKQA-SDTGSNDAH-NKKAVSRSAEQQP--SEKSTEPKTKPQ--DMISAGG-------- 172
++A DT ++A +AV+ + P +E+ TE + +M+SA
Sbjct: 956 ENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDT 1015
Query: 173 -ESVAGITAISGKPGD----------------KKKEKKSLTPAV--------PVE----S 203
E + + G D +K +++S P PV+
Sbjct: 1016 TEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE 1075
Query: 204 KPDKPSGKSGMDAALDDLIDTLGGPEETEE-----------ENTTYTGPEVSDPMSSTYI 252
+P++ + SG+ D ++ +TE + P+V++ + S+ +
Sbjct: 1076 RPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSEL 1135
Query: 253 EELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKT 312
+ E K +E++ ++ PP P + +DF T +
Sbjct: 1136 VTTCQAETLAGVKSQEMVMEQ---AIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIV 1192
Query: 313 EKEESTEVLKAQSAGTVRSAAPPQEKKR------------KVEKDTMSD----------- 349
E E EV +G + A P +K+R E+ M D
Sbjct: 1193 EIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSV 1252
Query: 350 QALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLK------ 403
+ + LS + GT++A+ D ++ K+V + E ++ +E LK
Sbjct: 1253 ETVSILSKTEGTQEADQYADEKT-KDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEE 1311
Query: 404 PATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPA- 462
KD L + P E E++ ++ +R + + +P+ E+ E + A
Sbjct: 1312 AECKKDDALELQSHAKSPPSPVEREMVVQV----EREKTEAEPTHVNEEKLEHETAVTVS 1367
Query: 463 -PVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKE 521
VS+ + +T I E ++L+G+ P LG++EA V K++
Sbjct: 1368 EEVSKQLLQTVNVPIIDGAKEVSSLEGSPP--------PCLGQEEA-------VCTKIQV 1412
Query: 522 KAKE---------EDREKLGEKE------ETIPP---DYRLEEVKD-----------KDG 552
++ E E+ + LGE ET+ P LEE +D
Sbjct: 1413 QSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDA 1472
Query: 553 KPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTT 612
P P + P + LS D G + +SLK++ EV Q
Sbjct: 1473 VPTGPDCQAKSTPVIVSATTKKGLSSDLEG-EKTTSLKWKS-------DEVDEQVACQEV 1524
Query: 613 QAGAPPRDTSQSDKDLDDALDKLSDSLGQR--QPDPDENKPMEDKVKEKAKAEHRDKLGE 670
+ D + L+ L+ S L Q Q D+ E+ E +E + +
Sbjct: 1525 KVSVAIEDLEPENGILE--LETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQ--- 1579
Query: 671 RDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQ 730
H++ + QD + K+ E+ + A D+ PI + + +S + +
Sbjct: 1580 ---------AHVIKADSQDAG-QETEKEGEEPQASAQDETPITSAKEESES-TAVGQAHS 1628
Query: 731 NTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 769
+ +KD + + + G D + EE P ++
Sbjct: 1629 DISKDMSEASEKTMTVEVEGSTVND--QQLEEVVLPSEE 1665
Score = 42.0 bits (97), Expect = 0.002
Identities = 137/729 (18%), Positives = 245/729 (33%), Gaps = 94/729 (12%)
Query: 72 SASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQ- 130
+AS + K S+ P ET + + S + E+ +EG+ K+ EP +
Sbjct: 225 AASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESP 284
Query: 131 ----ASDTGSN---------DAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 177
S+TGS KK R ++ E S + K + + + + A
Sbjct: 285 TSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAE 344
Query: 178 ITAISGKPGDKKKEKKSLTPAVPVES--KPDKPSGKSGMDAALDDLIDTLGGPEETEEEN 235
+ + +K + P P ES +P + ++ ++ + GP EE
Sbjct: 345 VAS------EKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGP---SEEK 395
Query: 236 TTYTGPEVSDPMSSTYIEELGKREV---TIPPKYRELLAKKEGITGP-PAD-----SSKP 286
EV D + EE+ EV T+ + E + E G PA+ ++P
Sbjct: 396 PAPLATEVFDEKIEVHQEEV-VAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEP 454
Query: 287 IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDT 346
+ A + + TC S + + +VL G V E E+
Sbjct: 455 QEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEV----EMLSSQERMK 510
Query: 347 MSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPAT 406
+ L+ L S G + + K++K ++ G D+E+ E+ PA
Sbjct: 511 VQGSPLKKLFTSTGLK---------------KLSGKKQKGKRGGGDEES--GEHTQVPAD 553
Query: 407 DKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSE 466
P+ +E+ K S + +E E C EK ++ E++ A + +
Sbjct: 554 S-------PDSQEEQKGESSASSPEEPEE----ITCLEKGLAEVQQDGEAEEGATSDGEK 602
Query: 467 AVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEE 526
+ P + K P V ++S + E D + + + A E
Sbjct: 603 --------KREGVTPWASFKKMVTPKKRVRRPSESDKEDELD-KVKSATLSSTESTASEM 653
Query: 527 DREKLGEKEETIPPDYRLEEVKDKDGKPLL----PKESKEQLPPMSEDFLLDALSEDFSG 582
E G EE P + + + + L+ K+ + E+ A+ D
Sbjct: 654 QEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQK 713
Query: 583 PQNASSLK--FEDAKLAAAISEVVSQTPASTTQAGAPPR----DTSQSDKDLDDALDKLS 636
A K D LA + Q +S QAG+P T +S K L K
Sbjct: 714 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 773
Query: 637 DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKP-- 694
L ++ D +E + + + + IP + D + PV+
Sbjct: 774 SKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIK-KFIPGRRKKRPDGKQEQAPVEDAG 832
Query: 695 PTKKSEDSKK-----PADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKN 749
PT +ED P + D ++ + + E + A + K S S+
Sbjct: 833 PTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMM 892
Query: 750 GGKAKDSAK 758
D +
Sbjct: 893 AAAVADGTR 901
>gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
sapiens]
Length = 1684
Score = 73.2 bits (178), Expect = 9e-13
Identities = 146/699 (20%), Positives = 267/699 (38%), Gaps = 104/699 (14%)
Query: 28 SEKTSESPSKPGEKK-GSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNP 86
+ + S S + G K G D +KA G + + T G A + + G++S + +P
Sbjct: 594 ARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGT-DGILAGSQEHDPGQGSSSPEQAGSP 652
Query: 87 TETKAVKT--------EPEKKSQSTKLSVVHEKKSQE---GKPKEHTEPKSLPKQASDTG 135
TE + V T P KKS+S KL E+KS++ G EH+ P + P +
Sbjct: 653 TEGEGVSTWESFKRLVTPRKKSKS-KL----EEKSEDSIAGSGVEHSTPDTEPGKEESWV 707
Query: 136 SND----AHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKE 191
S KK EQ P E + D ++ A+ + + ++
Sbjct: 708 SIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQA 767
Query: 192 KKSLT-PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPM--- 247
+KS P ++ K +S + + D EE + ++ V++P+
Sbjct: 768 QKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQV 827
Query: 248 ---SSTYIEELGKREVTI---PPKYRELLAKKEGITGPP--------------ADSSKPI 287
++ EE+ +REV PP E L + G A+++ P+
Sbjct: 828 EAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPL 887
Query: 288 GPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTM 347
G ++ +A +++ T +A + T+ ++TE +A V P E++ + ++ +
Sbjct: 888 GAEEGTEASAAEETTEMVSAVSQLTDSPDTTE--EATPVQEVEGGVPDIEEQERRTQEVL 945
Query: 348 SDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATD 407
A + S PE L+ ++ EA+ EE+ E G LK TD
Sbjct: 946 QAVAEKVKEESQLPGTGGPEDVLQPVQRA-EAERPEEQAEASG-----------LKKETD 993
Query: 408 KDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEA 467
K + E K +P ++ +++ + + E EK + TE E SE
Sbjct: 994 VVLK--VDAQEAKTEPFTQGKVVGQTT-----PESFEKAPQVTESIES---------SEL 1037
Query: 468 VCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPED----GKPVMDKVKEKA 523
V ++ + ++ +P D+VE DS D G D++ E
Sbjct: 1038 VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIH 1097
Query: 524 KEED----REKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ------LPPMSEDFLL 573
+E + + G + E +P +E + +E+KEQ L ++ +
Sbjct: 1098 EENEVASGTQSGGTEAEAVPAQ---KERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSV 1154
Query: 574 DALS--EDFSGPQNASSLKFEDAK-------LAAAISEVVSQTPASTTQAGAPPRDTSQS 624
+ +S G Q A E K L +I ++ + T+ T ++
Sbjct: 1155 ETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEA 1214
Query: 625 DKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 663
+ DDAL+ S + + P P E + + +EK +AE
Sbjct: 1215 ECKKDDALELQSHA--KSPPSPVEREMVVQVEREKTEAE 1251
Score = 47.8 bits (112), Expect = 4e-05
Identities = 133/710 (18%), Positives = 250/710 (35%), Gaps = 91/710 (12%)
Query: 2 SQPGQKPAASPRPRRAAAARRTHEHVSEKTS-----ESPSKPGEKKGSDEKKAASLGSSQ 56
S+ + ++ +P ++H +S E + GE+K E ++ +
Sbjct: 129 SKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTS 188
Query: 57 SSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEG 116
+ G T +G K+S P E + +E +K+ + K+ + K++
Sbjct: 189 PVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVA 248
Query: 117 KPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESV- 175
K T S AH Q+P+E + EP+ +SA E V
Sbjct: 249 SEKL-------------TASEQAH---------PQEPAESAHEPR------LSAEYEKVE 280
Query: 176 -AGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEE 234
+SG G +++ PA D+ + + + T+ E TEE+
Sbjct: 281 LPSEEQVSGSQGPSEEK-----PAPLATEVFDEKIEVHQEEVVAEVHVSTV--EERTEEQ 333
Query: 235 NTTYTGPEVSDPMSSTYIEELGKREV---TIPPKYRELLAKKEGITGPPADSSKPIGPDD 291
T EV + S EEL + + P + K+ ++G + PD+
Sbjct: 334 KT-----EVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDE 388
Query: 292 AIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQ---------SAGTVRSAAPPQEKKRKV 342
+ LS P + E S E +K Q S G + + Q+ KR
Sbjct: 389 KV--LSK-----PPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGG 441
Query: 343 EKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDE-----TIP 397
+ + + + + E S +E +E E+ L + +D E T
Sbjct: 442 GDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSD 501
Query: 398 SEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESK 457
E + + T + P+++ + SES+ DEL + + S +E EE K
Sbjct: 502 GEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDEL-DKVKSATLSSTESTASEMQEEMK 560
Query: 458 AAAPAP--------VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADP 509
+ P V +V ++ + S+ + + +A+ K +
Sbjct: 561 GSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAG 620
Query: 510 EDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL---PKESKEQLPP 566
+D + D + ++E D + E E V + L K+SK +L
Sbjct: 621 KDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEE 680
Query: 567 MSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDK 626
SED + + + S P + + I + P Q AP D +
Sbjct: 681 KSEDSIAGS-GVEHSTPDTEPGKEESWVSIKKFIPGRRKKRP-DGKQEQAPVEDAGPTGA 738
Query: 627 DLDD----ALDKLS--DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGE 670
+ DD A+ LS D++ + + + + + ++ ++KA E +L E
Sbjct: 739 NEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSE 788
Score = 47.4 bits (111), Expect = 5e-05
Identities = 160/822 (19%), Positives = 298/822 (36%), Gaps = 132/822 (16%)
Query: 8 PAASPRPRRAAAARRTHEHVS--EKTSESPSKPGEKKGSDEKKAASLG-SSQSSRTYAGG 64
P + A+AA T E VS + ++SP E E + Q RT
Sbjct: 886 PLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVL 945
Query: 65 TASATKVSASS---GATSKSSSMNPTETKAVKTEPEKKSQSTKLS----VVHEKKSQEGK 117
A A KV S G + P + +A PE++++++ L VV + +QE K
Sbjct: 946 QAVAEKVKEESQLPGTGGPEDVLQPVQ-RAEAERPEEQAEASGLKKETDVVLKVDAQEAK 1004
Query: 118 PKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 177
TEP + K T V+ S E S+E T Q AG +S
Sbjct: 1005 ----TEPFTQGKVVGQTTPESFEKAPQVTESIE------SSELVTTCQAETLAGVKSQEM 1054
Query: 178 ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAA----LDDLIDTLGGPEETEE 233
+ + P + P +S+ D + + DA D++++ EE E
Sbjct: 1055 VMEQAIPPDSVE---------TPTDSETDGSTPVADFDAPGTTQKDEIVEI---HEENEV 1102
Query: 234 ENTTYTGPEVSD---------PMSSTYI-----EELGKREVTIPPKYRE-------LLAK 272
+ T +G ++ P S+++ +E K E T+ +E +L+K
Sbjct: 1103 ASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK 1162
Query: 273 KEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTE---KEESTEVLKAQSAGTV 329
EG + + + L G + K TE K E TE + + +
Sbjct: 1163 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1222
Query: 330 R----SAAPP-----------QEKKRKVEKDTMSDQALEALSASLGTRQAEPEL----DL 370
+ +PP + +K + E ++++ LE +A + + +L ++
Sbjct: 1223 ELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNV 1282
Query: 371 RSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELI 430
I E + E C +E + ++ +++ + + L E+ K E+ I
Sbjct: 1283 PIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSS---EASFTLTAAAEEEKVLGETANI 1339
Query: 431 DELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP-EPATLKGT 489
E E + + + + + E AA P +AV C +S P AT K
Sbjct: 1340 LETGETLEPAGAHLVLEEKSSEKNEDFAAHPG--EDAVPTGPDCQAKSTPVIVSATTKKG 1397
Query: 490 VPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKD 549
+ D SL K ++D D + +VK ED E P+ + E++
Sbjct: 1398 LSSDLEGEKTTSL-KWKSDEVDEQVACQEVKVSVAIEDLE----------PENGILELET 1446
Query: 550 KDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPA 609
K K + ++ + A+ + + A+ + + + A + + SQ
Sbjct: 1447 KSSK-------------LVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAG 1493
Query: 610 STTQA-GAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMED-------------- 654
T+ G P+ ++Q + + A ++ S+S Q D +K M +
Sbjct: 1494 QETEKEGEEPQASAQDETPITSAKEE-SESTAVGQAHSDISKDMSEASEKTMTVEVEGST 1552
Query: 655 ----KVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 710
+++E + G ++P + H L +K + P K ++ DD +
Sbjct: 1553 VNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEP--KEDEKGDDVDDPE 1610
Query: 711 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGK 752
++ D D+ T+ S +T K K+ + + GK
Sbjct: 1611 NQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGK 1652
Score = 43.5 bits (101), Expect = 7e-04
Identities = 168/879 (19%), Positives = 313/879 (35%), Gaps = 174/879 (19%)
Query: 8 PAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGS-SQSSRTYAGGTA 66
PA P A R E +++ +S +P +K ++ K S + A GT
Sbjct: 746 PAVVPLSEYDAVEREKME--AQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTR 803
Query: 67 SATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKS 126
+AT + S + +S P E + E ++ V+ + E +P TEP
Sbjct: 804 AATIIEERSPSWISASVTEPLE------QVEAEAALLTEEVLEREVIAEEEPPTVTEPLP 857
Query: 127 LPKQA-SDTGSNDAH-NKKAVSRSAEQQP--SEKSTEPKTKPQ--DMISAGG-------- 172
++A DT ++A +AV+ + P +E+ TE + +M+SA
Sbjct: 858 ENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDT 917
Query: 173 -ESVAGITAISGKPGD----------------KKKEKKSLTPAV--------PVE----S 203
E + + G D +K +++S P PV+
Sbjct: 918 TEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE 977
Query: 204 KPDKPSGKSGMDAALDDLIDTLGGPEETEE-----------ENTTYTGPEVSDPMSSTYI 252
+P++ + SG+ D ++ +TE + P+V++ + S+ +
Sbjct: 978 RPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSEL 1037
Query: 253 EELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKT 312
+ E K +E++ ++ PP P + +DF T +
Sbjct: 1038 VTTCQAETLAGVKSQEMVMEQ---AIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIV 1094
Query: 313 EKEESTEVLKAQSAGTVRSAAPPQEKKR------------KVEKDTMSD----------- 349
E E EV +G + A P +K+R E+ M D
Sbjct: 1095 EIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSV 1154
Query: 350 QALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLK------ 403
+ + LS + GT++A+ D ++ K+V + E ++ +E LK
Sbjct: 1155 ETVSILSKTEGTQEADQYADEKT-KDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEE 1213
Query: 404 PATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPA- 462
KD L + P E E++ ++ +R + + +P+ E+ E + A
Sbjct: 1214 AECKKDDALELQSHAKSPPSPVEREMVVQV----EREKTEAEPTHVNEEKLEHETAVTVS 1269
Query: 463 -PVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKE 521
VS+ + +T I E ++L+G+ P LG++EA V K++
Sbjct: 1270 EEVSKQLLQTVNVPIIDGAKEVSSLEGSPP--------PCLGQEEA-------VCTKIQV 1314
Query: 522 KAKE---------EDREKLGEKE------ETIPP---DYRLEEVKD-----------KDG 552
++ E E+ + LGE ET+ P LEE +D
Sbjct: 1315 QSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDA 1374
Query: 553 KPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTT 612
P P + P + LS D G + +SLK++ EV Q
Sbjct: 1375 VPTGPDCQAKSTPVIVSATTKKGLSSDLEG-EKTTSLKWKS-------DEVDEQVACQEV 1426
Query: 613 QAGAPPRDTSQSDKDLDDALDKLSDSLGQR--QPDPDENKPMEDKVKEKAKAEHRDKLGE 670
+ D + L+ L+ S L Q Q D+ E+ E +E + +
Sbjct: 1427 KVSVAIEDLEPENGILE--LETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQ--- 1481
Query: 671 RDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQ 730
H++ + QD + K+ E+ + A D+ PI + + +S + +
Sbjct: 1482 ---------AHVIKADSQDAG-QETEKEGEEPQASAQDETPITSAKEESES-TAVGQAHS 1530
Query: 731 NTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 769
+ +KD + + + G D + EE P ++
Sbjct: 1531 DISKDMSEASEKTMTVEVEGSTVND--QQLEEVVLPSEE 1567
Score = 42.0 bits (97), Expect = 0.002
Identities = 137/729 (18%), Positives = 245/729 (33%), Gaps = 94/729 (12%)
Query: 72 SASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQ- 130
+AS + K S+ P ET + + S + E+ +EG+ K+ EP +
Sbjct: 127 AASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESP 186
Query: 131 ----ASDTGSN---------DAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 177
S+TGS KK R ++ E S + K + + + + A
Sbjct: 187 TSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAE 246
Query: 178 ITAISGKPGDKKKEKKSLTPAVPVES--KPDKPSGKSGMDAALDDLIDTLGGPEETEEEN 235
+ + +K + P P ES +P + ++ ++ + GP EE
Sbjct: 247 VAS------EKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGP---SEEK 297
Query: 236 TTYTGPEVSDPMSSTYIEELGKREV---TIPPKYRELLAKKEGITGP-PAD-----SSKP 286
EV D + EE+ EV T+ + E + E G PA+ ++P
Sbjct: 298 PAPLATEVFDEKIEVHQEEV-VAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEP 356
Query: 287 IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDT 346
+ A + + TC S + + +VL G V E E+
Sbjct: 357 QEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEV----EMLSSQERMK 412
Query: 347 MSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPAT 406
+ L+ L S G + + K++K ++ G D+E+ E+ PA
Sbjct: 413 VQGSPLKKLFTSTGLK---------------KLSGKKQKGKRGGGDEES--GEHTQVPAD 455
Query: 407 DKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSE 466
P+ +E+ K S + +E E C EK ++ E++ A + +
Sbjct: 456 S-------PDSQEEQKGESSASSPEEPEE----ITCLEKGLAEVQQDGEAEEGATSDGEK 504
Query: 467 AVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEE 526
+ P + K P V ++S + E D + + + A E
Sbjct: 505 --------KREGVTPWASFKKMVTPKKRVRRPSESDKEDELD-KVKSATLSSTESTASEM 555
Query: 527 DREKLGEKEETIPPDYRLEEVKDKDGKPLL----PKESKEQLPPMSEDFLLDALSEDFSG 582
E G EE P + + + + L+ K+ + E+ A+ D
Sbjct: 556 QEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQK 615
Query: 583 PQNASSLK--FEDAKLAAAISEVVSQTPASTTQAGAPPR----DTSQSDKDLDDALDKLS 636
A K D LA + Q +S QAG+P T +S K L K
Sbjct: 616 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 675
Query: 637 DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKP-- 694
L ++ D +E + + + + IP + D + PV+
Sbjct: 676 SKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIK-KFIPGRRKKRPDGKQEQAPVEDAG 734
Query: 695 PTKKSEDSKK-----PADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKN 749
PT +ED P + D ++ + + E + A + K S S+
Sbjct: 735 PTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMM 794
Query: 750 GGKAKDSAK 758
D +
Sbjct: 795 AAAVADGTR 803
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 72.8 bits (177), Expect = 1e-12
Identities = 186/839 (22%), Positives = 296/839 (35%), Gaps = 125/839 (14%)
Query: 10 ASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASAT 69
+SP+P+ A T VS K+S P + KK + K+ L + + T
Sbjct: 655 SSPQPKLKTAPVTTTSAVS-KSSPQPQQTSPKKDAAPKQ--DLSKAPEPKKPPPLVKQPT 711
Query: 70 KVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPK 129
+ S + + A EP S+ K V +K Q K T+ L
Sbjct: 712 LHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTD---LVS 768
Query: 130 QASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGIT--AISGKPGD 187
+S T D + K S++ E+ T+ KP GE V+ AI D
Sbjct: 769 SSSATTKPDIPSSKVQSQAEEKTTPPLKTD-SAKPSQSFPPTGEKVSPFDSKAIPRPASD 827
Query: 188 KK--------KEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 239
K E K PV+ K + ++ M D G P T
Sbjct: 828 SKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTA-- 885
Query: 240 GPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSD 299
G V P S +E +R IT P S+P P + +
Sbjct: 886 GQTVPTPQQSPKPQEQSRR----------FSLNLGSITDAP--KSQPTTPQETVTGKLFG 933
Query: 300 FTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL 359
F G + S + A G + P K+ Q +
Sbjct: 934 F--------GASIFSQASNLISTAGQPGPHSQSGPGAPMKQA----PAPSQPPTSQGPPK 981
Query: 360 GTRQAEPELDLRSIKEVDEAKAKE-EKLEKCGEDDETIP-SEYRLKPATDKDGKPLLPEP 417
T QA P +SI E KA EKLE E T+ +E KP KD K L EP
Sbjct: 982 STGQAPPA-PAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEP 1040
Query: 418 ---------EEKPKPRSESELI-DELS------EDFDR-SECKEKPS-----KPT-EKTE 454
E+ PKP S L EL+ +F+ +ECK + PT TE
Sbjct: 1041 QKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTE 1100
Query: 455 ESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGT---VPDD------AVEALADSLGKK 505
+ ++ + I+ PP P+ K + VP + AV + K+
Sbjct: 1101 IQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQ 1160
Query: 506 EAD--PEDGKPVMDKVKEKAK-------------------EEDREKLGEKEETIPPDYRL 544
E + E K +++KVKE E+D+ ++++ +P + +L
Sbjct: 1161 EQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKL 1220
Query: 545 ----EEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 600
E+++ ++ KPLL +E+ P + LL Q LK +++ A
Sbjct: 1221 IPEEEKIRSEEKKPLL----EEKKPTPEDKKLLPEAKTSAPEEQKHDLLK---SQVQIAE 1273
Query: 601 SEVVSQTPASTTQAGAPPRD-----TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDK 655
++ + T Q G P+ S + + L DK + ++ ++ P KP D+
Sbjct: 1274 EKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKP--DQ 1331
Query: 656 VKE-KAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDA 714
V+ K K E D + + P+ L D G + S P D++D +
Sbjct: 1332 VEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKG 1391
Query: 715 LSGDLDSCPSTTETSQNTAKDKCK-----KAASSSKAPKNGGKAKDSAKTTEETSKPKD 768
L D S S+ + + AK + +A +S+ A + K + + E +PKD
Sbjct: 1392 LKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPE--QPKD 1448
Score = 57.0 bits (136), Expect = 6e-08
Identities = 135/646 (20%), Positives = 216/646 (33%), Gaps = 115/646 (17%)
Query: 4 PGQKPAASPRPRRAAAAR----RTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSR 59
PG+ PA P + +A + + + P +PG K ++ ++ SQ
Sbjct: 446 PGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQP- 504
Query: 60 TYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPK 119
+TK +K S P TK +P S +Q+ P
Sbjct: 505 -------GSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPS----------AQQPSPA 547
Query: 120 EHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSE---KSTEPKTKPQDMISAGGE--- 173
+ + +S K S TGS VS SA+Q PS+ K+ P +++ E
Sbjct: 548 KPSAQQST-KPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKAN 606
Query: 174 ------------SVAG---------------------------ITAISGKPGDKKKEKKS 194
S+ G + + P K K
Sbjct: 607 FNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPV 666
Query: 195 LTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEE--ENTTYTGPEVSDPMSSTYI 252
T + +S P DAA + P++ + T G +
Sbjct: 667 TTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEA 726
Query: 253 EELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGP---DDAIDALSSDFTCGSPTAAG 309
+ L K PPK E E P AD KP P D +SS P
Sbjct: 727 DSLSK---PAPPK--EPSVPSEQDKAPVAD-DKPKQPKMVKPTTDLVSSSSATTKPDIPS 780
Query: 310 KKTE---KEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEP 366
K + +E++T LK SA +S P EK + + A ++ S P
Sbjct: 781 SKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIIS----HPGP 836
Query: 367 ELDLRSIKEVDEAKAKEEKLEKCGE-----DDETIPSEYRLKPATDKDGKPLLPEPEEKP 421
+ + K+VD + KEE + + D + +P P +P P++ P
Sbjct: 837 SSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSP 896
Query: 422 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEE-----------------SKAAAPAPV 464
KP+ +S L+ K +P+ P E S A P P
Sbjct: 897 KPQEQSRRF-SLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPH 955
Query: 465 SEAVCRTSMCSIQSAPPEPATLKGTVPD--DAVEALADSLGKKEADPEDGKPVMDKVKEK 522
S++ M AP +P T +G A A A S+ K+ E P +K++ K
Sbjct: 956 SQSGPGAPM-KQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKK---ETKAPAAEKLEPK 1011
Query: 523 AKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMS 568
A++ K E E+ PP + + + K +LP + ++ P S
Sbjct: 1012 AEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPES 1057
Score = 51.6 bits (122), Expect = 3e-06
Identities = 102/499 (20%), Positives = 189/499 (37%), Gaps = 90/499 (18%)
Query: 37 KPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEP 96
+PG++K E + SSQ ++ G + + S + + S+ PT+ K +
Sbjct: 1333 EPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGL 1392
Query: 97 EK----------------KSQSTKLSVVH-----------EKKSQ-----EGKPKEHTEP 124
+K K +ST LS++ EKK+Q +PK+ +
Sbjct: 1393 KKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKT 1452
Query: 125 KSLPKQASDTGSNDAHNKKAVSR-------SAEQQPSEKSTEPKTKPQDMISAGGE---S 174
+SL + T S + + R S + PS K + K++ D I+ E S
Sbjct: 1453 QSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDS 1512
Query: 175 VAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGK-SGMDAALDDLIDTLGGPEETEE 233
V + P ++K + S+ + E K + G D +I+ + +
Sbjct: 1513 VEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGS 1572
Query: 234 ENTTYTGPEVSDPMSSTYI----EELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGP 289
E+ + ++ + SST E GK ++T K+R L K T D+ +
Sbjct: 1573 EDDEFIRNQLKEISSSTESQKKEETKGKGKIT-AGKHRRLTRKSS--TSIDEDAGRRHSW 1629
Query: 290 DDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSD 349
D D + SP ++T+ +ES E++ G R + +E ++
Sbjct: 1630 HDEDDEAFDE----SPELKYRETKSQESEELVVTGGGGLRRF--------KTIELNSTIA 1677
Query: 350 QALEALSASLGTR---QAEPELDLRSIKEVDEAKAKEE-----------------KLEKC 389
A S+ T EPEL++ S+ + E +++ E +
Sbjct: 1678 DKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSL 1737
Query: 390 GEDDETIPSEYR-----LKPATDKDGKPLLP---EPEEKPKPRSESELIDELSEDFDRSE 441
ED ++ PS + + A + PLLP + E+ + R E EL+ E + + +
Sbjct: 1738 DEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQ 1797
Query: 442 CKEKPSKPTEKTEESKAAA 460
+ K S K ++ + A
Sbjct: 1798 QQRKSSSKKSKKDKDELRA 1816
Score = 47.0 bits (110), Expect = 7e-05
Identities = 148/723 (20%), Positives = 261/723 (36%), Gaps = 140/723 (19%)
Query: 56 QSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEK-----KSQSTKLSVVHE 110
Q+ R +G K+ + S PTE+ + KT K Q ++ E
Sbjct: 1110 QTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAE 1169
Query: 111 KKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISA 170
K E K KE + +P + + + SA Q+ E K P++
Sbjct: 1170 KVILE-KVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIR 1228
Query: 171 GGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTL----- 225
E + P DKK ++ T A P E K D KS + A + L +
Sbjct: 1229 SEEKKPLLEEKKPTPEDKKLLPEAKTSA-PEEQKHDLL--KSQVQIAEEKLEGRVAPKTV 1285
Query: 226 --GGPEETEEEN----TTYTGPEVSDPMSSTYIEE-----LGKREVTIPPKYRELLAKKE 274
G +T+ E T + P+ D + T E+ K + P K + +KE
Sbjct: 1286 QEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEK---TEKE 1342
Query: 275 GITGPPADSSKPIGPDDAIDA-LSSDFTCGSPTAAGK-----KTEKEESTEVLKAQSAGT 328
+ S +P P D SSD G ++ G+ T++++ + LK S
Sbjct: 1343 DDKSDTSSSQQPKSPQGLSDTGYSSD---GISSSLGEIPSLIPTDEKDILKGLKKDSFSQ 1399
Query: 329 VRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSI-----KEVDEAKAKE 383
S + P + K+E +S LEA +++L ++E + + K+ ++ ++
Sbjct: 1400 ESSPSSPSDLA-KLESTVLS--ILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLS 1456
Query: 384 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 443
E LE ++E S+ K KD + +P ++ + +SE +D+++
Sbjct: 1457 ETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDH---KEKSEFVDDITTR------- 1506
Query: 444 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 503
+P + EES + +PV + RTS+ S S
Sbjct: 1507 ---REPYDSVEESSESENSPVPQRKRRTSVGSSSS------------------------- 1538
Query: 504 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 563
++ K+ED + GE+E+ I +E D+D
Sbjct: 1539 -----------------DEYKQEDSQGSGEEEDFIRKQI-IEMSADEDAS---------- 1570
Query: 564 LPPMSEDFLLDALSEDFSGPQNASSLKFE-DAKLAAAISEVVSQTPASTTQAGAPPRDTS 622
++F+ + L E S ++ + + K+ A +++ +++ A R S
Sbjct: 1571 -GSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRH-S 1628
Query: 623 QSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY--- 679
D+D D+A D+ S L R+ E+ E+ V R K E + TI +Y
Sbjct: 1629 WHDED-DEAFDE-SPELKYRETKSQES---EELVVTGGGGLRRFKTIELNSTIADKYSAE 1683
Query: 680 -----RHLLDDNGQDKPVKPPTKKSEDSKK-------------PADDQDPIDALSGDLDS 721
L D + ++ T ED + P + +L D DS
Sbjct: 1684 SSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDS 1743
Query: 722 CPS 724
PS
Sbjct: 1744 SPS 1746
Score = 40.4 bits (93), Expect = 0.006
Identities = 147/755 (19%), Positives = 232/755 (30%), Gaps = 141/755 (18%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
+ P + P P P + A + H EK+ P+KP + K A +
Sbjct: 298 LPSPSKPPIQQPTPGKPPAQQPGH----EKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPV 353
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
GT TK A +K + K +P K+ + V Q G K
Sbjct: 354 QPPGT---TKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKP 410
Query: 121 HTEPKSLPKQ-ASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGIT 179
T+ PK A G +++ QQP P P G S
Sbjct: 411 PTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPG-----PGKIPAQQAGPGKTS----- 460
Query: 180 AISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 239
+ + G K + PA P +P GP + +
Sbjct: 461 --AQQTGPTKPPSQLPGPAKPPPQQP---------------------GPAKPPPQQPGSA 497
Query: 240 GPEVSDPMSSTYIEELGKREVTIPPKYRELLAK----KEGITGPPAD---SSKPIG--PD 290
P P S T PP + AK + G T PP+ S+KP P
Sbjct: 498 KPPSQQPGS------------TKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPS 545
Query: 291 DAIDALSSDFTCGSPTAAGKKTEKEE-STEVLKAQSAGTVRSAAP---PQEKKRKVEKDT 346
A + S T +GK + S + S G ++ P E V +
Sbjct: 546 PAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKA 605
Query: 347 MSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPAT 406
+ E + P L +KE + ++ G D +PS
Sbjct: 606 NFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKR--ALGGDLAPVPSS------- 656
Query: 407 DKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKE--KPSKPTEKTEESKAAAPAPV 464
P+P+ K P + + + + S ++ K+ P + K E K P V
Sbjct: 657 --------PQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPL-V 707
Query: 465 SEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAK 524
+ S + PPE +L P ++ + +A D KP K+ +
Sbjct: 708 KQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSE---QDKAPVADDKPKQPKMVKPTT 764
Query: 525 EEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESK--EQLPPMSEDFLLDALSEDFSG 582
+ + IP + ++K PL +K + PP E
Sbjct: 765 DLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGE------------- 811
Query: 583 PQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQR 642
K++ S+ + + PAS ++ + P +S+S GQ+
Sbjct: 812 ------------KVSPFDSKAIPR-PASDSKIISHPGPSSESK--------------GQK 844
Query: 643 QPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDS 702
Q DP + K K + K + K + PP R GQ P + S
Sbjct: 845 QVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPR---PTAGQTVPT------PQQS 895
Query: 703 KKPADDQDPIDALSGDLDSCP-STTETSQNTAKDK 736
KP + G + P S T Q T K
Sbjct: 896 PKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGK 930
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 72.8 bits (177), Expect = 1e-12
Identities = 186/839 (22%), Positives = 296/839 (35%), Gaps = 125/839 (14%)
Query: 10 ASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASAT 69
+SP+P+ A T VS K+S P + KK + K+ L + + T
Sbjct: 655 SSPQPKLKTAPVTTTSAVS-KSSPQPQQTSPKKDAAPKQ--DLSKAPEPKKPPPLVKQPT 711
Query: 70 KVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPK 129
+ S + + A EP S+ K V +K Q K T+ L
Sbjct: 712 LHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTD---LVS 768
Query: 130 QASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGIT--AISGKPGD 187
+S T D + K S++ E+ T+ KP GE V+ AI D
Sbjct: 769 SSSATTKPDIPSSKVQSQAEEKTTPPLKTD-SAKPSQSFPPTGEKVSPFDSKAIPRPASD 827
Query: 188 KK--------KEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 239
K E K PV+ K + ++ M D G P T
Sbjct: 828 SKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTA-- 885
Query: 240 GPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSD 299
G V P S +E +R IT P S+P P + +
Sbjct: 886 GQTVPTPQQSPKPQEQSRR----------FSLNLGSITDAP--KSQPTTPQETVTGKLFG 933
Query: 300 FTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL 359
F G + S + A G + P K+ Q +
Sbjct: 934 F--------GASIFSQASNLISTAGQPGPHSQSGPGAPMKQA----PAPSQPPTSQGPPK 981
Query: 360 GTRQAEPELDLRSIKEVDEAKAKE-EKLEKCGEDDETIP-SEYRLKPATDKDGKPLLPEP 417
T QA P +SI E KA EKLE E T+ +E KP KD K L EP
Sbjct: 982 STGQAPPA-PAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEP 1040
Query: 418 ---------EEKPKPRSESELI-DELS------EDFDR-SECKEKPS-----KPT-EKTE 454
E+ PKP S L EL+ +F+ +ECK + PT TE
Sbjct: 1041 QKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTE 1100
Query: 455 ESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGT---VPDD------AVEALADSLGKK 505
+ ++ + I+ PP P+ K + VP + AV + K+
Sbjct: 1101 IQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQ 1160
Query: 506 EAD--PEDGKPVMDKVKEKAK-------------------EEDREKLGEKEETIPPDYRL 544
E + E K +++KVKE E+D+ ++++ +P + +L
Sbjct: 1161 EQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKL 1220
Query: 545 ----EEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 600
E+++ ++ KPLL +E+ P + LL Q LK +++ A
Sbjct: 1221 IPEEEKIRSEEKKPLL----EEKKPTPEDKKLLPEAKTSAPEEQKHDLLK---SQVQIAE 1273
Query: 601 SEVVSQTPASTTQAGAPPRD-----TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDK 655
++ + T Q G P+ S + + L DK + ++ ++ P KP D+
Sbjct: 1274 EKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKP--DQ 1331
Query: 656 VKE-KAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDA 714
V+ K K E D + + P+ L D G + S P D++D +
Sbjct: 1332 VEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKG 1391
Query: 715 LSGDLDSCPSTTETSQNTAKDKCK-----KAASSSKAPKNGGKAKDSAKTTEETSKPKD 768
L D S S+ + + AK + +A +S+ A + K + + E +PKD
Sbjct: 1392 LKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPE--QPKD 1448
Score = 57.0 bits (136), Expect = 6e-08
Identities = 135/646 (20%), Positives = 216/646 (33%), Gaps = 115/646 (17%)
Query: 4 PGQKPAASPRPRRAAAAR----RTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSR 59
PG+ PA P + +A + + + P +PG K ++ ++ SQ
Sbjct: 446 PGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQP- 504
Query: 60 TYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPK 119
+TK +K S P TK +P S +Q+ P
Sbjct: 505 -------GSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPS----------AQQPSPA 547
Query: 120 EHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSE---KSTEPKTKPQDMISAGGE--- 173
+ + +S K S TGS VS SA+Q PS+ K+ P +++ E
Sbjct: 548 KPSAQQST-KPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKAN 606
Query: 174 ------------SVAG---------------------------ITAISGKPGDKKKEKKS 194
S+ G + + P K K
Sbjct: 607 FNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPV 666
Query: 195 LTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEE--ENTTYTGPEVSDPMSSTYI 252
T + +S P DAA + P++ + T G +
Sbjct: 667 TTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEA 726
Query: 253 EELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGP---DDAIDALSSDFTCGSPTAAG 309
+ L K PPK E E P AD KP P D +SS P
Sbjct: 727 DSLSK---PAPPK--EPSVPSEQDKAPVAD-DKPKQPKMVKPTTDLVSSSSATTKPDIPS 780
Query: 310 KKTE---KEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEP 366
K + +E++T LK SA +S P EK + + A ++ S P
Sbjct: 781 SKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIIS----HPGP 836
Query: 367 ELDLRSIKEVDEAKAKEEKLEKCGE-----DDETIPSEYRLKPATDKDGKPLLPEPEEKP 421
+ + K+VD + KEE + + D + +P P +P P++ P
Sbjct: 837 SSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSP 896
Query: 422 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEE-----------------SKAAAPAPV 464
KP+ +S L+ K +P+ P E S A P P
Sbjct: 897 KPQEQSRRF-SLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPH 955
Query: 465 SEAVCRTSMCSIQSAPPEPATLKGTVPD--DAVEALADSLGKKEADPEDGKPVMDKVKEK 522
S++ M AP +P T +G A A A S+ K+ E P +K++ K
Sbjct: 956 SQSGPGAPM-KQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKK---ETKAPAAEKLEPK 1011
Query: 523 AKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMS 568
A++ K E E+ PP + + + K +LP + ++ P S
Sbjct: 1012 AEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPES 1057
Score = 51.6 bits (122), Expect = 3e-06
Identities = 102/499 (20%), Positives = 189/499 (37%), Gaps = 90/499 (18%)
Query: 37 KPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEP 96
+PG++K E + SSQ ++ G + + S + + S+ PT+ K +
Sbjct: 1333 EPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGL 1392
Query: 97 EK----------------KSQSTKLSVVH-----------EKKSQ-----EGKPKEHTEP 124
+K K +ST LS++ EKK+Q +PK+ +
Sbjct: 1393 KKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKT 1452
Query: 125 KSLPKQASDTGSNDAHNKKAVSR-------SAEQQPSEKSTEPKTKPQDMISAGGE---S 174
+SL + T S + + R S + PS K + K++ D I+ E S
Sbjct: 1453 QSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDS 1512
Query: 175 VAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGK-SGMDAALDDLIDTLGGPEETEE 233
V + P ++K + S+ + E K + G D +I+ + +
Sbjct: 1513 VEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGS 1572
Query: 234 ENTTYTGPEVSDPMSSTYI----EELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGP 289
E+ + ++ + SST E GK ++T K+R L K T D+ +
Sbjct: 1573 EDDEFIRNQLKEISSSTESQKKEETKGKGKIT-AGKHRRLTRKSS--TSIDEDAGRRHSW 1629
Query: 290 DDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSD 349
D D + SP ++T+ +ES E++ G R + +E ++
Sbjct: 1630 HDEDDEAFDE----SPELKYRETKSQESEELVVTGGGGLRRF--------KTIELNSTIA 1677
Query: 350 QALEALSASLGTR---QAEPELDLRSIKEVDEAKAKEE-----------------KLEKC 389
A S+ T EPEL++ S+ + E +++ E +
Sbjct: 1678 DKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSL 1737
Query: 390 GEDDETIPSEYR-----LKPATDKDGKPLLP---EPEEKPKPRSESELIDELSEDFDRSE 441
ED ++ PS + + A + PLLP + E+ + R E EL+ E + + +
Sbjct: 1738 DEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQ 1797
Query: 442 CKEKPSKPTEKTEESKAAA 460
+ K S K ++ + A
Sbjct: 1798 QQRKSSSKKSKKDKDELRA 1816
Score = 47.0 bits (110), Expect = 7e-05
Identities = 148/723 (20%), Positives = 261/723 (36%), Gaps = 140/723 (19%)
Query: 56 QSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEK-----KSQSTKLSVVHE 110
Q+ R +G K+ + S PTE+ + KT K Q ++ E
Sbjct: 1110 QTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAE 1169
Query: 111 KKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISA 170
K E K KE + +P + + + SA Q+ E K P++
Sbjct: 1170 KVILE-KVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIR 1228
Query: 171 GGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTL----- 225
E + P DKK ++ T A P E K D KS + A + L +
Sbjct: 1229 SEEKKPLLEEKKPTPEDKKLLPEAKTSA-PEEQKHDLL--KSQVQIAEEKLEGRVAPKTV 1285
Query: 226 --GGPEETEEEN----TTYTGPEVSDPMSSTYIEE-----LGKREVTIPPKYRELLAKKE 274
G +T+ E T + P+ D + T E+ K + P K + +KE
Sbjct: 1286 QEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEK---TEKE 1342
Query: 275 GITGPPADSSKPIGPDDAIDA-LSSDFTCGSPTAAGK-----KTEKEESTEVLKAQSAGT 328
+ S +P P D SSD G ++ G+ T++++ + LK S
Sbjct: 1343 DDKSDTSSSQQPKSPQGLSDTGYSSD---GISSSLGEIPSLIPTDEKDILKGLKKDSFSQ 1399
Query: 329 VRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSI-----KEVDEAKAKE 383
S + P + K+E +S LEA +++L ++E + + K+ ++ ++
Sbjct: 1400 ESSPSSPSDLA-KLESTVLS--ILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLS 1456
Query: 384 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 443
E LE ++E S+ K KD + +P ++ + +SE +D+++
Sbjct: 1457 ETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDH---KEKSEFVDDITTR------- 1506
Query: 444 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 503
+P + EES + +PV + RTS+ S S
Sbjct: 1507 ---REPYDSVEESSESENSPVPQRKRRTSVGSSSS------------------------- 1538
Query: 504 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 563
++ K+ED + GE+E+ I +E D+D
Sbjct: 1539 -----------------DEYKQEDSQGSGEEEDFIRKQI-IEMSADEDAS---------- 1570
Query: 564 LPPMSEDFLLDALSEDFSGPQNASSLKFE-DAKLAAAISEVVSQTPASTTQAGAPPRDTS 622
++F+ + L E S ++ + + K+ A +++ +++ A R S
Sbjct: 1571 -GSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRH-S 1628
Query: 623 QSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY--- 679
D+D D+A D+ S L R+ E+ E+ V R K E + TI +Y
Sbjct: 1629 WHDED-DEAFDE-SPELKYRETKSQES---EELVVTGGGGLRRFKTIELNSTIADKYSAE 1683
Query: 680 -----RHLLDDNGQDKPVKPPTKKSEDSKK-------------PADDQDPIDALSGDLDS 721
L D + ++ T ED + P + +L D DS
Sbjct: 1684 SSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDS 1743
Query: 722 CPS 724
PS
Sbjct: 1744 SPS 1746
Score = 40.4 bits (93), Expect = 0.006
Identities = 147/755 (19%), Positives = 232/755 (30%), Gaps = 141/755 (18%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
+ P + P P P + A + H EK+ P+KP + K A +
Sbjct: 298 LPSPSKPPIQQPTPGKPPAQQPGH----EKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPV 353
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
GT TK A +K + K +P K+ + V Q G K
Sbjct: 354 QPPGT---TKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKP 410
Query: 121 HTEPKSLPKQ-ASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGIT 179
T+ PK A G +++ QQP P P G S
Sbjct: 411 PTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPG-----PGKIPAQQAGPGKTS----- 460
Query: 180 AISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 239
+ + G K + PA P +P GP + +
Sbjct: 461 --AQQTGPTKPPSQLPGPAKPPPQQP---------------------GPAKPPPQQPGSA 497
Query: 240 GPEVSDPMSSTYIEELGKREVTIPPKYRELLAK----KEGITGPPAD---SSKPIG--PD 290
P P S T PP + AK + G T PP+ S+KP P
Sbjct: 498 KPPSQQPGS------------TKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPS 545
Query: 291 DAIDALSSDFTCGSPTAAGKKTEKEE-STEVLKAQSAGTVRSAAP---PQEKKRKVEKDT 346
A + S T +GK + S + S G ++ P E V +
Sbjct: 546 PAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKA 605
Query: 347 MSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPAT 406
+ E + P L +KE + ++ G D +PS
Sbjct: 606 NFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKR--ALGGDLAPVPSS------- 656
Query: 407 DKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKE--KPSKPTEKTEESKAAAPAPV 464
P+P+ K P + + + + S ++ K+ P + K E K P V
Sbjct: 657 --------PQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPL-V 707
Query: 465 SEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAK 524
+ S + PPE +L P ++ + +A D KP K+ +
Sbjct: 708 KQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSE---QDKAPVADDKPKQPKMVKPTT 764
Query: 525 EEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESK--EQLPPMSEDFLLDALSEDFSG 582
+ + IP + ++K PL +K + PP E
Sbjct: 765 DLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGE------------- 811
Query: 583 PQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQR 642
K++ S+ + + PAS ++ + P +S+S GQ+
Sbjct: 812 ------------KVSPFDSKAIPR-PASDSKIISHPGPSSESK--------------GQK 844
Query: 643 QPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDS 702
Q DP + K K + K + K + PP R GQ P + S
Sbjct: 845 QVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPR---PTAGQTVPT------PQQS 895
Query: 703 KKPADDQDPIDALSGDLDSCP-STTETSQNTAKDK 736
KP + G + P S T Q T K
Sbjct: 896 PKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGK 930
>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
Length = 1163
Score = 71.6 bits (174), Expect = 3e-12
Identities = 162/837 (19%), Positives = 295/837 (35%), Gaps = 126/837 (15%)
Query: 24 HEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSA---------S 74
H + + +P P +K+++ L S SS+ + G++S T S +
Sbjct: 99 HGGSHQSSKWTPVGPAPSTSQSQKRSSGLQSGHSSQRTSAGSSSGTNSSGQRHDRESYNN 158
Query: 75 SGATSKSSSMNPTE-TKAVKTEPEKKSQSTKLSVVHEKK-SQEGKPKEHTEPKSL--PKQ 130
SG++S+ + +E +K+ + P K + L+ H + + KEH KS P
Sbjct: 159 SGSSSRKKGQHGSEHSKSRSSSPGKPQAVSSLNSSHSRSHGNDHHSKEHQRSKSPRDPDA 218
Query: 131 ASDTGS-----NDAHNKKAV-------SRSAEQQPS--------EKSTEPKTKPQDMISA 170
D+ S + H+ ++ S S Q+P+ ++S EPK + S
Sbjct: 219 NWDSPSRVPFSSGQHSTQSFPPSLMSKSNSMLQKPTAYVRPMDGQESMEPKLSSEHYSSQ 278
Query: 171 G-GESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDL-------I 222
G S+ + KP K K P+ P+++ S +D L ++ +
Sbjct: 279 SHGNSMTEL-----KPSSKAHLTKLKIPSQPLDASAS--GDVSCVDEILKEMTHSWPPPL 331
Query: 223 DTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPAD 282
+ P +TE + E T G+++ P K K + D
Sbjct: 332 TAIHTPCKTEPSKFPFPTKESQQSNFGT-----GEQKRYNPSKTSNGHQSKSMLK----D 382
Query: 283 SSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKV 342
K +D+ D T T ++E A ++ S+ E
Sbjct: 383 DLKLSSSEDSDGEQDCDKTMPRSTPGSNSEPSHHNSE--GADNSRDDSSSHSGSESSSGS 440
Query: 343 EKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDE--AKAKEEKLEKCGEDDETIPSEY 400
+ ++ S + + + EPE + ++D K K+ D IPS
Sbjct: 441 DSESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQ 500
Query: 401 RLKPA----------TDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPT 450
K TD G P+ P +S+ I + SE + S T
Sbjct: 501 GYKKEGREQGTGNSYTDTSG----PKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDST 556
Query: 451 EKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGK---KEA 507
+ P +A ++ P L ++P +A K K+
Sbjct: 557 TQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKE 616
Query: 508 DPEDGKPVMDKVKEKAKEEDREKLGE------------KEETIPPDYRLEEVKDKDGKPL 555
+P +K K K+ + +K E + E++PP + + + + P+
Sbjct: 617 SKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNRTPV 676
Query: 556 LPKESKEQ--------LPPMSEDFLLDALSEDFSGPQNASSL--KFEDAKLAAAISEVVS 605
P +E+ PM E LL LSE P + L K + L +
Sbjct: 677 KPSSVEEEDSFFRQRMFSPMEEKELLSPLSE----PDDRYPLIVKIDLNLLTRIPGKPYK 732
Query: 606 QT-PASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEH 664
+T P + P + T ++ K A +K+S+ ++ + D+N+ E K K K E
Sbjct: 733 ETEPPKGEKKNVPEKHTREAQKQ---ASEKVSNKGKRKHKNEDDNRASESK---KPKTED 786
Query: 665 RDKLGERDDT-------IPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 717
++ G + + + + LL P K P + K+ + + S
Sbjct: 787 KNSAGHKPSSNRESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSN 846
Query: 718 DLDSCPSTTETSQNTAKDKCKKAASSS-------KAPKNGGKAKDSAKTTEETSKPK 767
+++ S +T+K K + +SS KAP + SA T ++SKP+
Sbjct: 847 SNKETSGSSKNSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTL-DSSKPR 902
Score = 62.0 bits (149), Expect = 2e-09
Identities = 150/774 (19%), Positives = 258/774 (33%), Gaps = 137/774 (17%)
Query: 5 GQKPAASPRPRRAAAARRTHEHVSEKT---SESPSKPGEKKGSDEKKAASLGSSQSSRTY 61
GQ+ +++R+ +H SE + S SP KP + + S G+ S+ +
Sbjct: 148 GQRHDRESYNNSGSSSRKKGQHGSEHSKSRSSSPGKPQAVSSLNSSHSRSHGNDHHSKEH 207
Query: 62 AGGTA---------SATKVSASSGA----------TSKSSSMNPTETKAVKTEPEKKSQS 102
+ S ++V SSG SKS+SM T V+ ++S
Sbjct: 208 QRSKSPRDPDANWDSPSRVPFSSGQHSTQSFPPSLMSKSNSMLQKPTAYVRPMDGQESME 267
Query: 103 TKLSVVHEKKSQEG------KP--KEHTEPKSLPKQASDTGSND------------AHN- 141
KLS H G KP K H +P Q D ++ H+
Sbjct: 268 PKLSSEHYSSQSHGNSMTELKPSSKAHLTKLKIPSQPLDASASGDVSCVDEILKEMTHSW 327
Query: 142 ---KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEK------ 192
A+ + +PS+ K Q G + + S K K
Sbjct: 328 PPPLTAIHTPCKTEPSKFPFPTKESQQSNFGTGEQKRYNPSKTSNGHQSKSMLKDDLKLS 387
Query: 193 ------------KSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEET---EEENTT 237
K++ + P + G D + DD G + E ++
Sbjct: 388 SSEDSDGEQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESS 447
Query: 238 YTGPEVSDPMSS----------------TYIEELGKREVTIPPKYRELLA-----KKEG- 275
+ E ++P S ++ ++ +V+ + KKEG
Sbjct: 448 SSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGR 507
Query: 276 ----------ITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQS 325
+GP SS G D S+ G + + + V K Q
Sbjct: 508 EQGTGNSYTDTSGPKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQP 567
Query: 326 AGTVRSAAPPQEKKRKVEKDTMSDQALEALS-----ASLGTRQAEPELDLRSIKEVDEAK 380
++AA K+E +T D A S A+ G+R+ + + +S K
Sbjct: 568 KKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESKSSPRPTAEK 627
Query: 381 AKEEKLEKCGEDD-ETIPSEYRLKPATDKDGKPLLPEPEEKPK-PRSESELIDELSEDFD 438
K + K + E I ++ ++D D LP + PK P S + S + +
Sbjct: 628 KKYKSTSKSSQKSREIIETD---TSSSDSDESESLPPSSQTPKYPESNRTPVKPSSVEEE 684
Query: 439 RSECKEKPSKPTEKTE-ESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEA 497
S +++ P E+ E S + P + + + + P +P K T P +
Sbjct: 685 DSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKP--YKETEPPKGEKK 742
Query: 498 LADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP 557
+EA + + V +K K K K ED + E ++ + E+ KP
Sbjct: 743 NVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKP-----KTEDKNSAGHKPSSN 797
Query: 558 KESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEV-------------- 603
+ES +Q +D L +GP + K E IS+
Sbjct: 798 RESSKQSAAKEKDLLPSP-----AGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKETS 852
Query: 604 -VSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKV 656
S+ +ST++ TS S K++ + S + P D +KP K+
Sbjct: 853 GSSKNSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTLDSSKPRRTKL 906
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 67.0 bits (162), Expect = 6e-11
Identities = 101/401 (25%), Positives = 155/401 (38%), Gaps = 65/401 (16%)
Query: 307 AAGKKTEKEESTEVLKAQSAGTVRSAAPP-------------QEKKRKVEKDTMSDQALE 353
AA +K E+ E+ E A V++ AP QE++ + ++ SDQA E
Sbjct: 491 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 550
Query: 354 ALSASLGT------RQAEPELDLRSIKEVDEAK---AKEEKLEKCGEDDETIPSEYRLKP 404
S G+ Q E E + + E EAK EEK E+ +E + KP
Sbjct: 551 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 610
Query: 405 ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE-ESKAAAPAP 463
K P P E+ P +S + ++ +S +EK P K+ E K +P
Sbjct: 611 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV- 669
Query: 464 VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD--SLGKKEADPEDGKPVMDKVKE 521
S P K VP VE +GK E E+ K +VKE
Sbjct: 670 --------------SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK----EVKE 711
Query: 522 KAKEEDREKLGEKEETIPPDYRLEE-VKD----------KDGKPLLPKESKEQLPPMSED 570
KEE EK EK + +P + E VK+ K K L KE+KE+ P+ ++
Sbjct: 712 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 771
Query: 571 FLLDAL-----SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSD 625
+ SE+ + A + ED + + E + T + G+ +
Sbjct: 772 KEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV-EGKEEVEQETKEKGS---GREEEK 827
Query: 626 KDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 666
+ + LD LS + ++ D E K + K EK +E D
Sbjct: 828 GVVTNGLD-LSPADEKKGGDKSEEKVVVTKTVEKITSEGGD 867
Score = 48.5 bits (114), Expect = 2e-05
Identities = 89/391 (22%), Positives = 138/391 (35%), Gaps = 52/391 (13%)
Query: 294 DALSSDFTCGSPTAAGKKTEKEESTE--VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQA 351
D L+ AA +K + E T G + + PP K++K +
Sbjct: 386 DLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPK 445
Query: 352 LEAL---------SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 402
L+ + ++E E L +I E KEEK E E +E +E
Sbjct: 446 LKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE 505
Query: 403 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK---------- 452
A K PE +E+ + E E +E E+ + ++ + +EK
Sbjct: 506 VAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE 565
Query: 453 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDG 512
EE + A A EA + ++ E AT + V D VE +K P
Sbjct: 566 QEEGETEAEAEGEEAEAKEEK-KVEEKSEEVATKEELVADAKVEK-----PEKAKSPVPK 619
Query: 513 KPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFL 572
PV +K K + E EK ++ P +EE K K P P E K + P
Sbjct: 620 SPVEEKGKSPVPKSPVE---EKGKSPVPKSPVEE-KGKSPVPKSPVEEKGKSPVSK---- 671
Query: 573 LDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDAL 632
+ E P S + E+AK A + + Q + P++ K+
Sbjct: 672 -SPVEEKAKSPVPKSPV--EEAKSKAEVGK-GEQKEEEEKEVKEAPKEEKVEKKE----- 722
Query: 633 DKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 663
++ D E K E VKE+A AE
Sbjct: 723 --------EKPKDVPEKKKAESPVKEEAVAE 745
Score = 43.9 bits (102), Expect = 6e-04
Identities = 85/380 (22%), Positives = 148/380 (38%), Gaps = 59/380 (15%)
Query: 69 TKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVH----EKKSQEGKPKEHTEP 124
T ++ + K E K + E E++ + K S V E K +EG+ +E E
Sbjct: 474 TAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEE--EE 531
Query: 125 KSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGK 184
++ D G A S AE+ SEK E ++ ++ GE+ A G+
Sbjct: 532 GQEEEEEEDEG--------AKSDQAEEGGSEK--EGSSEKEEGEQEEGETEA---EAEGE 578
Query: 185 PGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVS 244
+ K+EKK VE K ++ + K EE + +
Sbjct: 579 EAEAKEEKK-------VEEKSEEVATK-----------------EELVADAKVEKPEKAK 614
Query: 245 DPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGS 304
P+ + +EE GK V P E K P + K P ++ S
Sbjct: 615 SPVPKSPVEEKGKSPV--PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKS 672
Query: 305 PTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA 364
P K+ +S V +A+S V +E++++V K+ ++ +E ++
Sbjct: 673 PVEEKAKSPVPKS-PVEEAKSKAEVGKGEQKEEEEKEV-KEAPKEEKVE--------KKE 722
Query: 365 EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPR 424
E D+ K+ E+ KEE + + +++ + L+ T ++GKPL E +EK K
Sbjct: 723 EKPKDVPEKKKA-ESPVKEEAVAEVVTITKSV--KVHLEKETKEEGKPLQQE-KEKEKAG 778
Query: 425 SESELIDELSEDFDRSECKE 444
E +E S+ + KE
Sbjct: 779 GEGGSEEEGSDKGAKGSRKE 798
Score = 42.0 bits (97), Expect = 0.002
Identities = 46/221 (20%), Positives = 74/221 (33%), Gaps = 17/221 (7%)
Query: 4 PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAG 63
P K + E K+ ++ EK+GS EK+ ++ G
Sbjct: 518 PEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEG 577
Query: 64 GTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEK------------ 111
A A + + + ++ A +PEK S V EK
Sbjct: 578 EEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 637
Query: 112 KSQEGKPKEHTEPKS---LPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMI 168
K + PK E K +PK + +K V A + P KS + K + +
Sbjct: 638 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKA-KSPVPKSPVEEAKSKAEV 696
Query: 169 SAGGESVAGITAISGKPGDKKKEKKSLTPA-VPVESKPDKP 208
G + + P ++K EKK P VP + K + P
Sbjct: 697 GKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESP 737
Score = 38.9 bits (89), Expect = 0.018
Identities = 75/371 (20%), Positives = 128/371 (34%), Gaps = 31/371 (8%)
Query: 25 EHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSM 84
E V+ K S + E K + +K G + G + + S S
Sbjct: 504 EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 563
Query: 85 NPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKS---LPKQASDTGSNDAHN 141
E + E E + K E+KS+E KE + P++A
Sbjct: 564 GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVE 623
Query: 142 KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 201
+K S + EK P P+ + G+S + P ++K KS PV
Sbjct: 624 EKGKSPVPKSPVEEKGKSP--VPKSPVEEKGKS-----PVPKSPVEEK--GKSPVSKSPV 674
Query: 202 ESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVT 261
E K P KS ++ A +G E+ EEE EV + +E+ ++
Sbjct: 675 EEKAKSPVPKSPVEEAKSKA--EVGKGEQKEEEE-----KEVKEAPKEEKVEKKEEKPKD 727
Query: 262 IPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVL 321
+P K + KE +K + + G P K EKE++
Sbjct: 728 VPEKKKAESPVKEEAVAEVVTITKSV----KVHLEKETKEEGKPLQQEK--EKEKAGGEG 781
Query: 322 KAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPE------LDLRSIKE 375
++ G+ + A +++ V + + +E + G+ + E + LDL E
Sbjct: 782 GSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADE 841
Query: 376 VDEAKAKEEKL 386
EEK+
Sbjct: 842 KKGGDKSEEKV 852
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 67.0 bits (162), Expect = 6e-11
Identities = 101/401 (25%), Positives = 155/401 (38%), Gaps = 65/401 (16%)
Query: 307 AAGKKTEKEESTEVLKAQSAGTVRSAAPP-------------QEKKRKVEKDTMSDQALE 353
AA +K E+ E+ E A V++ AP QE++ + ++ SDQA E
Sbjct: 115 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174
Query: 354 ALSASLGT------RQAEPELDLRSIKEVDEAK---AKEEKLEKCGEDDETIPSEYRLKP 404
S G+ Q E E + + E EAK EEK E+ +E + KP
Sbjct: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234
Query: 405 ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE-ESKAAAPAP 463
K P P E+ P +S + ++ +S +EK P K+ E K +P
Sbjct: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV- 293
Query: 464 VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD--SLGKKEADPEDGKPVMDKVKE 521
S P K VP VE +GK E E+ K +VKE
Sbjct: 294 --------------SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK----EVKE 335
Query: 522 KAKEEDREKLGEKEETIPPDYRLEE-VKD----------KDGKPLLPKESKEQLPPMSED 570
KEE EK EK + +P + E VK+ K K L KE+KE+ P+ ++
Sbjct: 336 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 395
Query: 571 FLLDAL-----SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSD 625
+ SE+ + A + ED + + E + T + G+ +
Sbjct: 396 KEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV-EGKEEVEQETKEKGS---GREEEK 451
Query: 626 KDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 666
+ + LD LS + ++ D E K + K EK +E D
Sbjct: 452 GVVTNGLD-LSPADEKKGGDKSEEKVVVTKTVEKITSEGGD 491
Score = 48.5 bits (114), Expect = 2e-05
Identities = 89/391 (22%), Positives = 138/391 (35%), Gaps = 52/391 (13%)
Query: 294 DALSSDFTCGSPTAAGKKTEKEESTE--VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQA 351
D L+ AA +K + E T G + + PP K++K +
Sbjct: 10 DLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPK 69
Query: 352 LEAL---------SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 402
L+ + ++E E L +I E KEEK E E +E +E
Sbjct: 70 LKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE 129
Query: 403 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK---------- 452
A K PE +E+ + E E +E E+ + ++ + +EK
Sbjct: 130 VAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE 189
Query: 453 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDG 512
EE + A A EA + ++ E AT + V D VE +K P
Sbjct: 190 QEEGETEAEAEGEEAEAKEEK-KVEEKSEEVATKEELVADAKVEK-----PEKAKSPVPK 243
Query: 513 KPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFL 572
PV +K K + E EK ++ P +EE K K P P E K + P
Sbjct: 244 SPVEEKGKSPVPKSPVE---EKGKSPVPKSPVEE-KGKSPVPKSPVEEKGKSPVSK---- 295
Query: 573 LDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDAL 632
+ E P S + E+AK A + + Q + P++ K+
Sbjct: 296 -SPVEEKAKSPVPKSPV--EEAKSKAEVGK-GEQKEEEEKEVKEAPKEEKVEKKE----- 346
Query: 633 DKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 663
++ D E K E VKE+A AE
Sbjct: 347 --------EKPKDVPEKKKAESPVKEEAVAE 369
Score = 43.9 bits (102), Expect = 6e-04
Identities = 85/380 (22%), Positives = 148/380 (38%), Gaps = 59/380 (15%)
Query: 69 TKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVH----EKKSQEGKPKEHTEP 124
T ++ + K E K + E E++ + K S V E K +EG+ +E E
Sbjct: 98 TAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEE--EE 155
Query: 125 KSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGK 184
++ D G A S AE+ SEK E ++ ++ GE+ A G+
Sbjct: 156 GQEEEEEEDEG--------AKSDQAEEGGSEK--EGSSEKEEGEQEEGETEA---EAEGE 202
Query: 185 PGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVS 244
+ K+EKK VE K ++ + K EE + +
Sbjct: 203 EAEAKEEKK-------VEEKSEEVATK-----------------EELVADAKVEKPEKAK 238
Query: 245 DPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGS 304
P+ + +EE GK V P E K P + K P ++ S
Sbjct: 239 SPVPKSPVEEKGKSPV--PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKS 296
Query: 305 PTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA 364
P K+ +S V +A+S V +E++++V K+ ++ +E ++
Sbjct: 297 PVEEKAKSPVPKS-PVEEAKSKAEVGKGEQKEEEEKEV-KEAPKEEKVE--------KKE 346
Query: 365 EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPR 424
E D+ K+ E+ KEE + + +++ + L+ T ++GKPL E +EK K
Sbjct: 347 EKPKDVPEKKKA-ESPVKEEAVAEVVTITKSV--KVHLEKETKEEGKPLQQE-KEKEKAG 402
Query: 425 SESELIDELSEDFDRSECKE 444
E +E S+ + KE
Sbjct: 403 GEGGSEEEGSDKGAKGSRKE 422
Score = 42.0 bits (97), Expect = 0.002
Identities = 46/221 (20%), Positives = 74/221 (33%), Gaps = 17/221 (7%)
Query: 4 PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAG 63
P K + E K+ ++ EK+GS EK+ ++ G
Sbjct: 142 PEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEG 201
Query: 64 GTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEK------------ 111
A A + + + ++ A +PEK S V EK
Sbjct: 202 EEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 261
Query: 112 KSQEGKPKEHTEPKS---LPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMI 168
K + PK E K +PK + +K V A + P KS + K + +
Sbjct: 262 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKA-KSPVPKSPVEEAKSKAEV 320
Query: 169 SAGGESVAGITAISGKPGDKKKEKKSLTPA-VPVESKPDKP 208
G + + P ++K EKK P VP + K + P
Sbjct: 321 GKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESP 361
Score = 38.9 bits (89), Expect = 0.018
Identities = 75/371 (20%), Positives = 128/371 (34%), Gaps = 31/371 (8%)
Query: 25 EHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSM 84
E V+ K S + E K + +K G + G + + S S
Sbjct: 128 EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 187
Query: 85 NPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKS---LPKQASDTGSNDAHN 141
E + E E + K E+KS+E KE + P++A
Sbjct: 188 GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVE 247
Query: 142 KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 201
+K S + EK P P+ + G+S + P ++K KS PV
Sbjct: 248 EKGKSPVPKSPVEEKGKSP--VPKSPVEEKGKS-----PVPKSPVEEK--GKSPVSKSPV 298
Query: 202 ESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVT 261
E K P KS ++ A +G E+ EEE EV + +E+ ++
Sbjct: 299 EEKAKSPVPKSPVEEAKSKA--EVGKGEQKEEEE-----KEVKEAPKEEKVEKKEEKPKD 351
Query: 262 IPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVL 321
+P K + KE +K + + G P K EKE++
Sbjct: 352 VPEKKKAESPVKEEAVAEVVTITKSV----KVHLEKETKEEGKPLQQEK--EKEKAGGEG 405
Query: 322 KAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPE------LDLRSIKE 375
++ G+ + A +++ V + + +E + G+ + E + LDL E
Sbjct: 406 GSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADE 465
Query: 376 VDEAKAKEEKL 386
EEK+
Sbjct: 466 KKGGDKSEEKV 476
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 66.6 bits (161), Expect = 8e-11
Identities = 93/434 (21%), Positives = 160/434 (36%), Gaps = 70/434 (16%)
Query: 3 QPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYA 62
+PGQ PA P A+R T + + E K EKK + E K +
Sbjct: 283 KPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKE 342
Query: 63 GGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTK--LSVVHEKKSQEGKPKE 120
K + T + + + A K E ++ S+ TK V K ++ K ++
Sbjct: 343 TAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEK 402
Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
H EP PK+ PS+K + KT+ E + ++
Sbjct: 403 HVEPAKSPKKEHSV------------------PSDKQVKAKTE------RAKEEIGAVSI 438
Query: 181 ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 240
PG KKE+K+ T V E + +K SGK+ + L D + + G EE +
Sbjct: 439 KKAVPG--KKEEKT-TKTVEQEIRKEK-SGKT--SSILKDK-EPIKGKEEKVPASLKEKE 491
Query: 241 PEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDF 300
PE E++ K + PK +L KKE P + + D
Sbjct: 492 PETKKD------EKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDI 545
Query: 301 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKR-----------KVEKDTMSD 349
T + K E+ +VLK A T+ A P+ K+ K +K +
Sbjct: 546 VKPEKTVSHGKPEE----KVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTP 601
Query: 350 QALEALSAS------LGTRQAEPELDLRSIKEVDEAKAKE----------EKLEKCGEDD 393
+ ++ S + ++++ + D++ ++E + KE EK + +D
Sbjct: 602 KGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDV 661
Query: 394 ETIPSEYRLKPATD 407
E +P+ + K T+
Sbjct: 662 EDVPASKKAKEGTE 675
Score = 65.9 bits (159), Expect = 1e-10
Identities = 130/600 (21%), Positives = 220/600 (36%), Gaps = 73/600 (12%)
Query: 7 KPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTA 66
K +P R + TH K E + +K EKKA + + T
Sbjct: 147 KTEKQEKPERKIQTKVTH-----KEKEKGKEKVREKEKPEKKATH--KEKIEKKEKPETK 199
Query: 67 SATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKS 126
+ K + KS E K K E K++ + V E + KPKE +
Sbjct: 200 TLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAK----VKEVQKTPSKPKEKED--- 252
Query: 127 LPKQASDTGSNDAHNKKAVSR-------SAEQQPSEKSTEPKTKPQDMISAGGESVAGIT 179
K+ + ++ ++ A R + +P + P P + S
Sbjct: 253 --KEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS---RPTPASP 307
Query: 180 AISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 239
A+ K G+KKK +K +T + K D KS + A+D G ET++
Sbjct: 308 ALEEKEGEKKKAEKKVTSETKKKEKEDIKK-KSEKETAIDVEKKEPGKASETKQGTVKIA 366
Query: 240 GPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSD 299
+ + K+ + + KKE P K ++ SD
Sbjct: 367 AQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKE-------HSVPSD 419
Query: 300 FTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL 359
+ T K E+ + + KA E++ + EK + L+
Sbjct: 420 KQVKAKTERAK--EEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIK 477
Query: 360 GTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEE 419
G + P S+KE + K+EK+ K G++ + P + + K K+ KP P+ ++
Sbjct: 478 GKEEKVP----ASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGK----KEEKP-EPQIKK 528
Query: 420 KPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEE-------SKAAAPAPVSEAVCR-T 471
+ KP + SE + +D + E KP EK + K A P P +A R
Sbjct: 529 EAKP-AISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHRER 587
Query: 472 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 531
SI++ P+P T KGT + E+ GKK+ + + + K K K EK+
Sbjct: 588 EPPSIKTDKPKP-TPKGT--SEVTES-----GKKKTEISEKE---SKEKADMKHLREEKV 636
Query: 532 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 591
++E++ +L V K KP + E +P + +ED S + S + F
Sbjct: 637 STRKESL----QLHNV-TKAEKPARVSKDVEDVPASKK---AKEGTEDVSPTKQKSPISF 688
Score = 63.5 bits (153), Expect = 7e-10
Identities = 122/634 (19%), Positives = 231/634 (36%), Gaps = 104/634 (16%)
Query: 104 KLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTK 163
K + +K ++ KP+ + K K+ +K ++ ++ EK +P+TK
Sbjct: 140 KKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETK 199
Query: 164 P---QDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDD 220
+ + E T K G ++K K++ V+ P KP
Sbjct: 200 TLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPK----------- 248
Query: 221 LIDTLGGPEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYRELLAKKEGITGP 279
E+ ++E + E D + Y+ ++ + +L + P
Sbjct: 249 --------EKEDKEKAAVSKHEQKDQYAFCRYMIDIFV--------HGDLKPGQSPAIPP 292
Query: 280 PADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKK 339
P + + P A AL KK EK+ ++E K + ++ K
Sbjct: 293 PLPTEQASRPTPASPALEEK------EGEKKKAEKKVTSETKKKEK----------EDIK 336
Query: 340 RKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSE 399
+K EK+T D + + T+Q ++ ++ + DE K +K +K P+E
Sbjct: 337 KKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKK--------PAE 388
Query: 400 YRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS-ECKEKPSKPTEKTEESKA 458
++ K EP + PK E S D+ + K + +K K
Sbjct: 389 VEQPKGKKQEKKEKHVEPAKSPK--------KEHSVPSDKQVKAKTERAKEEIGAVSIKK 440
Query: 459 AAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK 518
A P E +T I+ K ++ GK+E P K +K
Sbjct: 441 AVPGKKEEKTTKTVEQEIRKE-------KSGKTSSILKDKEPIKGKEEKVPASLK---EK 490
Query: 519 VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE 578
E K+E K G++ + PP +L+ K++ +P + KE+K P +SE + +
Sbjct: 491 EPETKKDEKMSKAGKEVKPKPP--QLQGKKEEKPEPQIKKEAK---PAISEKVQIH--KQ 543
Query: 579 DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDS 638
D P+ S + K V+ Q A T + A P+ T +++ ++ S
Sbjct: 544 DIVKPEKTVSHGKPEEK-------VLKQVKAVTIEKTAKPKPTKKAEH-----REREPPS 591
Query: 639 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK 698
+ +P P E K K E + E++ + +HL ++ +
Sbjct: 592 IKTDKPKPTPKGTSEVTESGKKKTE----ISEKESKEKADMKHLREEKVSTRKESLQLHN 647
Query: 699 SEDSKKPADDQDPIDALSGDLDSCPSTTETSQNT 732
++KPA +S D++ P++ + + T
Sbjct: 648 VTKAEKPA-------RVSKDVEDVPASKKAKEGT 674
Score = 43.9 bits (102), Expect = 6e-04
Identities = 65/307 (21%), Positives = 110/307 (35%), Gaps = 59/307 (19%)
Query: 485 TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRL 544
T KG + + + K E + + + KV K KE+ +EK+ EKE+
Sbjct: 128 TDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHK 187
Query: 545 EEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVV 604
E+++ K+ KP +KEQ + + + ++ G K E K AA + V
Sbjct: 188 EKIEKKE-KPETKTLAKEQKKAKTAEKSEEKTKKEVKGG------KQEKVKQTAAKVKEV 240
Query: 605 SQTPASTTQAGAPPRDTSQSDKDLD---------------DALDKLSDSLGQRQPDPDEN 649
+TP+ + + + D D S ++ P +
Sbjct: 241 QKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS 300
Query: 650 KP------MEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK--SED 701
+P +E+K EK KAE K V TKK ED
Sbjct: 301 RPTPASPALEEKEGEKKKAE--------------------------KKVTSETKKKEKED 334
Query: 702 SKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTE 761
KK ++ + ID + +ET Q T K + AA + ++ K K A+ +
Sbjct: 335 IKKKSEKETAIDV---EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQ 391
Query: 762 ETSKPKD 768
K ++
Sbjct: 392 PKGKKQE 398
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 64.7 bits (156), Expect = 3e-10
Identities = 113/755 (14%), Positives = 251/755 (33%), Gaps = 33/755 (4%)
Query: 28 SEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPT 87
++ +S S G+ SD + S SS SS + ++ + S S + S SS + +
Sbjct: 534 NDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDS 593
Query: 88 ETK-----AVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNK 142
++ + ++ S S+ S + KS K + + +SD+ S+D+ +
Sbjct: 594 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDN 653
Query: 143 KAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVE 202
S S+ S S++ D + S + ++ S D +S + +
Sbjct: 654 SDSSDSSNSSNSSDSSD----SSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSD 709
Query: 203 SKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTI 262
S S S +++ D ++ + + +++ + + SS + + +
Sbjct: 710 SDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSD 769
Query: 263 PPKYRELLAKKEGITGPPADSSKPIGPDDAIDAL-SSDFTCGSPTAAGKKTEKEESTEVL 321
+ + +DS+ D+ D+ SSD + S ++ + +S+
Sbjct: 770 SSD-----SSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSS 824
Query: 322 KAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKA 381
+ ++ ++ + + SD S S + + D + + ++
Sbjct: 825 DSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSD 884
Query: 382 KEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSE 441
E D + ++D D + S S D S
Sbjct: 885 SNESSNSSDSSDSS--------NSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSS 936
Query: 442 CKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPD--DAVEALA 499
S ++ ++ S ++ + S++ + S+ ++ D D+ ++
Sbjct: 937 DSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSD 996
Query: 500 DSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE 559
S +D D D + + + D + D
Sbjct: 997 SSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSD-SSDSSDSSDSSDSSDSS 1055
Query: 560 SKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPR 619
+ S+ S+ ++ S D+ ++ S+ + +S + +
Sbjct: 1056 NSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1115
Query: 620 DTSQS--DKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPP 677
D+S S D D+ D S D ++ D ++ D D +
Sbjct: 1116 DSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSS 1175
Query: 678 EYRHLLD-DNGQDKPVKPPTKKSEDSKKPADDQDPIDA--LSGDLDSCPSTTETSQNTAK 734
+ + D + D + S DS +D D D+ S DS S+ + N +
Sbjct: 1176 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESS 1235
Query: 735 DKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 769
D + SS + N + DS+ +++ TS D+
Sbjct: 1236 DSSDSSDSSDSS--NSSDSSDSSDSSDSTSDSNDE 1268
Score = 64.7 bits (156), Expect = 3e-10
Identities = 105/747 (14%), Positives = 235/747 (31%), Gaps = 22/747 (2%)
Query: 28 SEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPT 87
S+ S S S + SD + S SS SS + +S + S+ S + SS + +
Sbjct: 572 SDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSES 631
Query: 88 ETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSR 147
++ ++ + ++ S + S ++ + + S+D+ N S
Sbjct: 632 DSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSD 691
Query: 148 SAEQQPSEKSTEPKTKPQD-----MISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVE 202
S++ S +S++ S+ S ++ S D S +
Sbjct: 692 SSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSN 751
Query: 203 SKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTI 262
S S S + D D+ + + ++ + SS + + +
Sbjct: 752 SSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSD 811
Query: 263 PPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLK 322
+ + + +DSS D+ D SSD + GS + + +++ S++
Sbjct: 812 SSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSD--SSDSSDGSDSDSSNRSDSSNSSDSSD 869
Query: 323 AQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAK 382
+ + ++ + SD + + S S + + D + + E+
Sbjct: 870 SSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNS 929
Query: 383 EEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSEC 442
+ + + ++D + + S+ D S D S
Sbjct: 930 SDNSNSSDSSNSS--------DSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSN 981
Query: 443 KEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSL 502
S ++ ++ S ++ + S++ + ++ + + D+ ++ S
Sbjct: 982 SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSD 1041
Query: 503 GKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKE 562
+D D + + + + + D E D S
Sbjct: 1042 SSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDS--SESSDSSDSSNSSDSSDS 1099
Query: 563 QLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTS 622
S D + S D S N+S ++ S S + S+ + + S
Sbjct: 1100 SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDS 1159
Query: 623 QSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHL 682
D D+ D S D ++ D ++ D D + +
Sbjct: 1160 SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD---- 1215
Query: 683 LDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAAS 742
+ D + S +S +D D D+ + S S + S + + D+ +
Sbjct: 1216 -SSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSK 1274
Query: 743 SSKAPKNGGKAKDSAKTTEETSKPKDD 769
S NG + ++ ++ DD
Sbjct: 1275 SGNGNNNGSDSDSDSEGSDSNHSTSDD 1301
Score = 58.9 bits (141), Expect = 2e-08
Identities = 124/751 (16%), Positives = 246/751 (32%), Gaps = 36/751 (4%)
Query: 28 SEKTSESPSKPGEKKGSDEKKAASLGS-SQSSRTYAGGTASATKVSASSGATSKSSSMNP 86
SE + S S+ SDE K GS S+ + + S T S S+G + + N
Sbjct: 479 SESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDN- 537
Query: 87 TETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVS 146
KS S K K + S +SD+ S+D+ N + S
Sbjct: 538 -----------DKSDSGK-----GKSDSSDSDSSDSSNSSDSSDSSDSDSSDS-NSSSDS 580
Query: 147 RSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKE-KKSLTPAVPVESKP 205
S++ S+ S + + + S + ++ S D K + KS + + +SK
Sbjct: 581 DSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKS 640
Query: 206 DKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPK 265
D S + D D+ ++ +++ + S SS + + + +
Sbjct: 641 DSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSE 700
Query: 266 YRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQS 325
+ + + +DSS D D+ +S + S ++ + S + S
Sbjct: 701 SSDSSDSSDSDSSDSSDSSNSNSSDS--DSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDS 758
Query: 326 AGTVRSAAPPQEKKRKVEKDTM-SDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEE 384
+ + S+ D+ S + ++ ++S + + S D + + +
Sbjct: 759 SDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDS 818
Query: 385 KLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKE 444
+ + S + D + RS+S + S+ D S +
Sbjct: 819 DSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSD 878
Query: 445 KPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGK 504
S ++ E S ++ + S + S S S+ ++ D+ E+ S
Sbjct: 879 S-SDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNS----SDSSESSNSSDNS 933
Query: 505 KEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQL 564
+D + D + + D + D S
Sbjct: 934 NSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSD 993
Query: 565 PPMSEDFLLDALSEDFSGPQNAS----SLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 620
S D + S D S ++S S D+ ++ S+ + +S + + D
Sbjct: 994 SSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD 1053
Query: 621 TSQS--DKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPE 678
+S S D D+ D S D E+ D ++ D D + +
Sbjct: 1054 SSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSD 1113
Query: 679 YRHLLD-DNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKC 737
D N D + S DS +D D ++ S DS S+ + + + D
Sbjct: 1114 SSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSES-SDSSDSSDSSDSSDSSDSSDSS 1172
Query: 738 KKAASSSKAPKNGGKAKDSAKTTEETSKPKD 768
+ SS+ + + + + ++S D
Sbjct: 1173 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD 1203
Score = 57.8 bits (138), Expect = 4e-08
Identities = 114/750 (15%), Positives = 241/750 (32%), Gaps = 50/750 (6%)
Query: 33 ESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAV 92
+ P+ E G+D+ + S +S S + AS + + N +++K
Sbjct: 463 DDPNSSDESNGNDDANSESDNNSSS------------RGDASYNSDESKDNGNGSDSKGA 510
Query: 93 KTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQ 152
+ + + T S + + + ++ +SD+ S+D+ N S S++
Sbjct: 511 EDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSD 570
Query: 153 PSEKSTEPKTKPQDMISA-GGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGK 211
S+ ++ + D S+ +S + ++ S D S + +SK D S K
Sbjct: 571 SSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSD--SSK 628
Query: 212 SGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLA 271
S D++ D ++ + + + + SS + + + +
Sbjct: 629 SESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSD-----S 683
Query: 272 KKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRS 331
+ +DSS D+ D+ SD + S ++ ++ + S + S+ + S
Sbjct: 684 SNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSN---SSDSSDSSNS 740
Query: 332 AAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGE 391
+ D+ S S + + D + + +++ + +
Sbjct: 741 SDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNS 800
Query: 392 DDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTE 451
D + S+ + D S+S S+ D S+ + +
Sbjct: 801 SDSSNSSD----SSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSS 856
Query: 452 KTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPED 511
+S ++ + S +S S S E + + +DS ++D D
Sbjct: 857 NRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDS---------SDSSNSSDSDSSD 907
Query: 512 GKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDF 571
D + E + + D +S +
Sbjct: 908 SSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSD 967
Query: 572 LLDALSEDFSGPQNAS----------SLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT 621
D+ S D S N+S S D+ ++ S+ + +S + + D+
Sbjct: 968 SSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDS 1027
Query: 622 SQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRH 681
S S D D+ D S D ++ D ++ D D + E
Sbjct: 1028 SNS-SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSD 1086
Query: 682 LLD-DNGQDKPVKPPTKKSEDSKKPADDQDPIDA--LSGDLDSCPSTTETSQNTAKDKCK 738
D N D + S DS +D D D+ S DS S+ + + + D
Sbjct: 1087 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSD 1146
Query: 739 KAASSSKAPKNGGKAKDSAKTTEETSKPKD 768
+ SS + + + + ++S D
Sbjct: 1147 SSESSDSSDSSDSSDSSDSSDSSDSSDSSD 1176
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 64.3 bits (155), Expect = 4e-10
Identities = 151/754 (20%), Positives = 247/754 (32%), Gaps = 74/754 (9%)
Query: 31 TSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETK 90
TS+ S K+ + E K + + Q+S T SA + + ++K + PT
Sbjct: 136 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD--LAPTSKV 193
Query: 91 AVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAE 150
K P+ ++ + ++ K+ PKE + PK+ + T K A + E
Sbjct: 194 LAKPTPKAETTTKGPALTTPKEPTPTTPKEPAS--TTPKEPTPTTI-----KSAPTTPKE 246
Query: 151 QQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSG 210
P+ + P T P++ + A T P K+ + T + P K P+
Sbjct: 247 PAPTTTKSAPTT-PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPT- 304
Query: 211 KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELL 270
T P T + T P+ P + K PK
Sbjct: 305 -------------TPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT 351
Query: 271 AKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVR 330
A K+ P + + P P + + + + +P T K T + T
Sbjct: 352 APKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 410
Query: 331 SAAPPQEKKRKVEKD----TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKL 386
+ P+E K+ T + A T EP + KE K+
Sbjct: 411 APTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKPAP 468
Query: 387 EKCGEDDETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDRSE 441
E T P E P T K P PE EKP P + EL E+
Sbjct: 469 TTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE----- 521
Query: 442 CKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEAL 498
P+ P E + KAAAP E T + P EPA T K T P +
Sbjct: 522 --PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KGT 578
Query: 499 ADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPK 558
A + K+ A KP ++ +E +K P K P PK
Sbjct: 579 APTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTPK 629
Query: 559 ES-----KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQ 613
E KE P + L E P + K +LA ++ + T +
Sbjct: 630 EPAPTTPKEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKPA 685
Query: 614 AGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDD 673
P + K+ K P P ++ ++ H+ D+
Sbjct: 686 PTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----DE 741
Query: 674 TIPPEYRHLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETSQ 730
+ P ++ P +P PT K+ + KP D + DL + P TT +
Sbjct: 742 STPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAP 801
Query: 731 NTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETS 764
K+ ++++ + ++ TT++T+
Sbjct: 802 KMTKETATTTEKTTESKITATTTQVTSTTTQDTT 835
Score = 50.4 bits (119), Expect = 6e-06
Identities = 101/497 (20%), Positives = 164/497 (32%), Gaps = 36/497 (7%)
Query: 285 KPIGPDDAIDALSS-DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE 343
KP D+A L + DF +P + + K ++ + R + PP K
Sbjct: 81 KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 140
Query: 344 KDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 402
T++ + +E + +Q + KE + + + +EK D S+
Sbjct: 141 SLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLA 195
Query: 403 KPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 459
KP + P L P+E P P + E ++ + K P+ P E + +
Sbjct: 196 KPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKS 254
Query: 460 APAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKV 519
AP E T+ + P EPA P A + K+ A KP
Sbjct: 255 APTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 314
Query: 520 KEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLPPMSEDFLL 573
KE A +E +E P K+ P PK+ KE P ++
Sbjct: 315 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAP 374
Query: 574 DALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS-QSDKDLDD 630
E + + E A + ++ PA TT AP P++ S + K+
Sbjct: 375 TTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 428
Query: 631 ALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 689
K ++P P K P KE A + + T P E
Sbjct: 429 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAPTTPKETAP 484
Query: 690 KPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKN 749
K T + + P + P +L P+T E T ++ + AP
Sbjct: 485 TTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTTPKAAAPNT 542
Query: 750 GGKAKDSAKTTEETSKP 766
K+ A TT + P
Sbjct: 543 ---PKEPAPTTPKEPAP 556
Score = 47.4 bits (111), Expect = 5e-05
Identities = 129/623 (20%), Positives = 208/623 (33%), Gaps = 97/623 (15%)
Query: 7 KPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTA 66
K A P+ A + +P+ P E + KK A + + T TA
Sbjct: 424 KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETA 483
Query: 67 SATKVSASSGATSKSSSMNP------TETKAVKTEPEKKSQST--KLSVVHEKKSQEGKP 118
T + K + P T + T PE+ + +T + + K + P
Sbjct: 484 PTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP 543
Query: 119 KEH--TEPK----SLPKQASDTGSNDAH--NKKAVSRSAEQQPSEKSTEPKTKPQDMISA 170
KE T PK + PK+ + T + K + + ++P+ +T K P+++
Sbjct: 544 KEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP-TTPKKPAPKELAPT 602
Query: 171 GGESVAGITAISGKP----GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 226
+ T P G K P P E P P G + + T
Sbjct: 603 TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPK 661
Query: 227 GPEETEEENTTYTGPE--VSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSS 284
P E TT GP SD + T +E T P + KK T P
Sbjct: 662 KPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP---TTPKEPAPTTPKKPAPTTPET--- 715
Query: 285 KPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP-----PQEKK 339
P +S+ T PT K + EST L A+ +P P K
Sbjct: 716 ----PPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALENSPKEPGVPTTKT 769
Query: 340 RKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSE 399
K M+ A + + E DLR+ E A K K E ++T S+
Sbjct: 770 PAATKPEMTTTAKDKTT----------ERDLRTTPETTTAAPKMTK-ETATTTEKTTESK 818
Query: 400 Y-----RLKPATDKDGKP----------LLPEPEEKPKPRSESELIDELSEDFDRSECKE 444
++ T +D P L P+ K + +E++++ E
Sbjct: 819 ITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK----------PE 868
Query: 445 KPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ-----------SAPPEPATLKGTVPD- 492
+ +KP ++ SKA P P S + P P + T+P+
Sbjct: 869 ETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPEL 928
Query: 493 DAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET-----IPPDYRLEEV 547
+ +A+++ + P P V+ K ED G + ET P + E
Sbjct: 929 NPTSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHMLLRPHVFMPEVT 985
Query: 548 KDKDGKPLLPKESKEQLPPMSED 570
D D P +P + P +S++
Sbjct: 986 PDMDYLPRVPNQGIIINPMLSDE 1008
Score = 46.6 bits (109), Expect = 9e-05
Identities = 107/524 (20%), Positives = 175/524 (33%), Gaps = 57/524 (10%)
Query: 12 PRPRRAAAARRTHEHVSEKTSE--SPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASAT 69
P P +A T + S T++ +P+ P E + KK A + + T A T
Sbjct: 403 PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 462
Query: 70 KVSASSGATSKSSSMNPTETKAVKTEPEKKSQST--KLSVVHEKKSQEGKPKE--HTEPK 125
+ + + P ET T P+K + +T KL+ +K P+E T P+
Sbjct: 463 TKKPAPTTPKEPAPTTPKET--APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE 520
Query: 126 SLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKP 185
+ + A + E P+ T P++ + A T P
Sbjct: 521 EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAP 580
Query: 186 GDKKKEKKSLTPAVPVESKPDKPSGKS-GMDAALDDLIDTLGGPEETEEENTTYTGPEVS 244
K+ P + P KP+ K + T P T + T T P+
Sbjct: 581 TTLKE---------PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPK-- 629
Query: 245 DPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGS 304
+P +T E T P K+ T P + K + P S+ +
Sbjct: 630 EPAPTTPKEP----APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPA 685
Query: 305 PTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA 364
PT T KE + K + T + AP + T S+ + + T
Sbjct: 686 PT-----TPKETAPTTPKEPAPTTPKKPAPTTP---ETPPPTTSEVSTPTTTKEPTTIHK 737
Query: 365 EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPR 424
P+ + KA E ++ G P+ KP K E + + P
Sbjct: 738 SPDESTPELSAEPTPKALENSPKEPGVPTTKTPA--ATKPEMTTTAKDKTTERDLRTTPE 795
Query: 425 SESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPA 484
+ + + ++ + TEKT ESK A TS + + P +
Sbjct: 796 TTTA----------APKMTKETATTTEKTTESKITATTTQV-----TSTTTQDTTPFKIT 840
Query: 485 TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 528
TLK T V ++ E +M+K +E AK +DR
Sbjct: 841 TLKTTTLAPKVTTTKKTITTTE--------IMNKPEETAKPKDR 876
Score = 44.3 bits (103), Expect = 4e-04
Identities = 57/267 (21%), Positives = 93/267 (34%), Gaps = 15/267 (5%)
Query: 277 TGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 336
T P ++KPI P ++ S S T + T + + T Q++ +
Sbjct: 114 TSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSA 173
Query: 337 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 396
++ + +EK + D A + + T +AE ++ E K E
Sbjct: 174 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 233
Query: 397 PSEYRLKPATDKDGKPL------------LPEPEEKPKPRSESELIDELSEDFDRSECKE 444
P+ + P T K+ P P ++P P + E +++ + K
Sbjct: 234 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 293
Query: 445 KPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA-TLKGTVPDDAVEALADSL 502
P+ P E + K AP E T + P EPA T K P E A +
Sbjct: 294 APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP-APTA 352
Query: 503 GKKEADPEDGKPVMDKVKEKAKEEDRE 529
KK A +P KE A +E
Sbjct: 353 PKKPAPTTPKEPAPTTPKEPAPTTTKE 379
Score = 33.9 bits (76), Expect = 0.59
Identities = 61/325 (18%), Positives = 113/325 (34%), Gaps = 25/325 (7%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
+ +P P P+ A + +P+ P + K+ A + + T
Sbjct: 583 LKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 642
Query: 61 YAGGTASATKVSASSGATSK--------SSSMNPTETKAVKTEPEKKSQSTKLSVVHEKK 112
GTA T + K +++ PT T + K P ++ +
Sbjct: 643 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 702
Query: 113 SQEGKPKEHTEPKSLPKQASDTGS-NDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAG 171
+ KP T P++ P S+ + + +S ++ E S EP K +
Sbjct: 703 TTPKKPAP-TTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKE 761
Query: 172 GESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEET 231
T + KP + K T + + P+ + M +T E+T
Sbjct: 762 PGVPTTKTPAATKP-EMTTTAKDKTTERDLRTTPETTTAAPKMTK------ETATTTEKT 814
Query: 232 EEENTTYTGPEVSD--PMSSTYIEELGKREVTIPPKY---RELLAKKEGITGPPADSSKP 286
E T T +V+ +T + + T+ PK ++ + E I P +++KP
Sbjct: 815 TESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE-IMNKPEETAKP 873
Query: 287 IGPDDAIDALSSDFTCGSPTAAGKK 311
D A ++ ++ PT A KK
Sbjct: 874 --KDRATNSKATTPKPQKPTKAPKK 896
Score = 32.0 bits (71), Expect = 2.2
Identities = 54/255 (21%), Positives = 93/255 (36%), Gaps = 21/255 (8%)
Query: 521 EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDF 580
E+ +E D + +K + PDY + KD K K+ PP+ + E
Sbjct: 38 ERGRECDCDAQCKKYDKCCPDYESFCAEVKDNKKNRTKKKPTPKPPV--------VDEAG 89
Query: 581 SGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT--SQSDKDLDDALDKLSDS 638
SG N K + VS +P TT PR + SD + +L ++
Sbjct: 90 SGLDN-GDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKET 148
Query: 639 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDT--IPPEYRHLLDDNGQ-DKPVKPP 695
+ + NK KEK + + E+ + P + L + + K P
Sbjct: 149 TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP 208
Query: 696 TKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKC----KKAASSSKAPKNGG 751
+ P ++P A + + P+T +++ T K+ K A ++ K P
Sbjct: 209 ALTTPKEPTPTTPKEP--ASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA-PT 265
Query: 752 KAKDSAKTTEETSKP 766
K+ A TT + P
Sbjct: 266 TTKEPAPTTPKEPAP 280
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 64.3 bits (155), Expect = 4e-10
Identities = 151/754 (20%), Positives = 247/754 (32%), Gaps = 74/754 (9%)
Query: 31 TSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETK 90
TS+ S K+ + E K + + Q+S T SA + + ++K + PT
Sbjct: 177 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD--LAPTSKV 234
Query: 91 AVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAE 150
K P+ ++ + ++ K+ PKE + PK+ + T K A + E
Sbjct: 235 LAKPTPKAETTTKGPALTTPKEPTPTTPKEPAS--TTPKEPTPTTI-----KSAPTTPKE 287
Query: 151 QQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSG 210
P+ + P T P++ + A T P K+ + T + P K P+
Sbjct: 288 PAPTTTKSAPTT-PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPT- 345
Query: 211 KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELL 270
T P T + T P+ P + K PK
Sbjct: 346 -------------TPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT 392
Query: 271 AKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVR 330
A K+ P + + P P + + + + +P T K T + T
Sbjct: 393 APKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 451
Query: 331 SAAPPQEKKRKVEKD----TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKL 386
+ P+E K+ T + A T EP + KE K+
Sbjct: 452 APTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKPAP 509
Query: 387 EKCGEDDETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDRSE 441
E T P E P T K P PE EKP P + EL E+
Sbjct: 510 TTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE----- 562
Query: 442 CKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEAL 498
P+ P E + KAAAP E T + P EPA T K T P +
Sbjct: 563 --PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KGT 619
Query: 499 ADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPK 558
A + K+ A KP ++ +E +K P K P PK
Sbjct: 620 APTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTPK 670
Query: 559 ES-----KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQ 613
E KE P + L E P + K +LA ++ + T +
Sbjct: 671 EPAPTTPKEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKPA 726
Query: 614 AGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDD 673
P + K+ K P P ++ ++ H+ D+
Sbjct: 727 PTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----DE 782
Query: 674 TIPPEYRHLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETSQ 730
+ P ++ P +P PT K+ + KP D + DL + P TT +
Sbjct: 783 STPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAP 842
Query: 731 NTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETS 764
K+ ++++ + ++ TT++T+
Sbjct: 843 KMTKETATTTEKTTESKITATTTQVTSTTTQDTT 876
Score = 50.4 bits (119), Expect = 6e-06
Identities = 101/497 (20%), Positives = 164/497 (32%), Gaps = 36/497 (7%)
Query: 285 KPIGPDDAIDALSS-DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE 343
KP D+A L + DF +P + + K ++ + R + PP K
Sbjct: 122 KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 181
Query: 344 KDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 402
T++ + +E + +Q + KE + + + +EK D S+
Sbjct: 182 SLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLA 236
Query: 403 KPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 459
KP + P L P+E P P + E ++ + K P+ P E + +
Sbjct: 237 KPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKS 295
Query: 460 APAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKV 519
AP E T+ + P EPA P A + K+ A KP
Sbjct: 296 APTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 355
Query: 520 KEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLPPMSEDFLL 573
KE A +E +E P K+ P PK+ KE P ++
Sbjct: 356 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAP 415
Query: 574 DALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS-QSDKDLDD 630
E + + E A + ++ PA TT AP P++ S + K+
Sbjct: 416 TTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 469
Query: 631 ALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 689
K ++P P K P KE A + + T P E
Sbjct: 470 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAPTTPKETAP 525
Query: 690 KPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKN 749
K T + + P + P +L P+T E T ++ + AP
Sbjct: 526 TTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTTPKAAAPNT 583
Query: 750 GGKAKDSAKTTEETSKP 766
K+ A TT + P
Sbjct: 584 ---PKEPAPTTPKEPAP 597
Score = 47.4 bits (111), Expect = 5e-05
Identities = 129/623 (20%), Positives = 208/623 (33%), Gaps = 97/623 (15%)
Query: 7 KPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTA 66
K A P+ A + +P+ P E + KK A + + T TA
Sbjct: 465 KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETA 524
Query: 67 SATKVSASSGATSKSSSMNP------TETKAVKTEPEKKSQST--KLSVVHEKKSQEGKP 118
T + K + P T + T PE+ + +T + + K + P
Sbjct: 525 PTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP 584
Query: 119 KEH--TEPK----SLPKQASDTGSNDAH--NKKAVSRSAEQQPSEKSTEPKTKPQDMISA 170
KE T PK + PK+ + T + K + + ++P+ +T K P+++
Sbjct: 585 KEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP-TTPKKPAPKELAPT 643
Query: 171 GGESVAGITAISGKP----GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 226
+ T P G K P P E P P G + + T
Sbjct: 644 TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPK 702
Query: 227 GPEETEEENTTYTGPE--VSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSS 284
P E TT GP SD + T +E T P + KK T P
Sbjct: 703 KPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP---TTPKEPAPTTPKKPAPTTPET--- 756
Query: 285 KPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP-----PQEKK 339
P +S+ T PT K + EST L A+ +P P K
Sbjct: 757 ----PPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALENSPKEPGVPTTKT 810
Query: 340 RKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSE 399
K M+ A + + E DLR+ E A K K E ++T S+
Sbjct: 811 PAATKPEMTTTAKDKTT----------ERDLRTTPETTTAAPKMTK-ETATTTEKTTESK 859
Query: 400 Y-----RLKPATDKDGKP----------LLPEPEEKPKPRSESELIDELSEDFDRSECKE 444
++ T +D P L P+ K + +E++++ E
Sbjct: 860 ITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK----------PE 909
Query: 445 KPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ-----------SAPPEPATLKGTVPD- 492
+ +KP ++ SKA P P S + P P + T+P+
Sbjct: 910 ETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPEL 969
Query: 493 DAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET-----IPPDYRLEEV 547
+ +A+++ + P P V+ K ED G + ET P + E
Sbjct: 970 NPTSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHMLLRPHVFMPEVT 1026
Query: 548 KDKDGKPLLPKESKEQLPPMSED 570
D D P +P + P +S++
Sbjct: 1027 PDMDYLPRVPNQGIIINPMLSDE 1049
Score = 46.6 bits (109), Expect = 9e-05
Identities = 107/524 (20%), Positives = 175/524 (33%), Gaps = 57/524 (10%)
Query: 12 PRPRRAAAARRTHEHVSEKTSE--SPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASAT 69
P P +A T + S T++ +P+ P E + KK A + + T A T
Sbjct: 444 PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 503
Query: 70 KVSASSGATSKSSSMNPTETKAVKTEPEKKSQST--KLSVVHEKKSQEGKPKE--HTEPK 125
+ + + P ET T P+K + +T KL+ +K P+E T P+
Sbjct: 504 TKKPAPTTPKEPAPTTPKET--APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE 561
Query: 126 SLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKP 185
+ + A + E P+ T P++ + A T P
Sbjct: 562 EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAP 621
Query: 186 GDKKKEKKSLTPAVPVESKPDKPSGKS-GMDAALDDLIDTLGGPEETEEENTTYTGPEVS 244
K+ P + P KP+ K + T P T + T T P+
Sbjct: 622 TTLKE---------PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPK-- 670
Query: 245 DPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGS 304
+P +T E T P K+ T P + K + P S+ +
Sbjct: 671 EPAPTTPKEP----APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPA 726
Query: 305 PTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA 364
PT T KE + K + T + AP + T S+ + + T
Sbjct: 727 PT-----TPKETAPTTPKEPAPTTPKKPAPTTP---ETPPPTTSEVSTPTTTKEPTTIHK 778
Query: 365 EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPR 424
P+ + KA E ++ G P+ KP K E + + P
Sbjct: 779 SPDESTPELSAEPTPKALENSPKEPGVPTTKTPA--ATKPEMTTTAKDKTTERDLRTTPE 836
Query: 425 SESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPA 484
+ + + ++ + TEKT ESK A TS + + P +
Sbjct: 837 TTTA----------APKMTKETATTTEKTTESKITATTTQV-----TSTTTQDTTPFKIT 881
Query: 485 TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 528
TLK T V ++ E +M+K +E AK +DR
Sbjct: 882 TLKTTTLAPKVTTTKKTITTTE--------IMNKPEETAKPKDR 917
Score = 44.3 bits (103), Expect = 4e-04
Identities = 57/267 (21%), Positives = 93/267 (34%), Gaps = 15/267 (5%)
Query: 277 TGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 336
T P ++KPI P ++ S S T + T + + T Q++ +
Sbjct: 155 TSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSA 214
Query: 337 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 396
++ + +EK + D A + + T +AE ++ E K E
Sbjct: 215 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 274
Query: 397 PSEYRLKPATDKDGKPL------------LPEPEEKPKPRSESELIDELSEDFDRSECKE 444
P+ + P T K+ P P ++P P + E +++ + K
Sbjct: 275 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 334
Query: 445 KPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA-TLKGTVPDDAVEALADSL 502
P+ P E + K AP E T + P EPA T K P E A +
Sbjct: 335 APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP-APTA 393
Query: 503 GKKEADPEDGKPVMDKVKEKAKEEDRE 529
KK A +P KE A +E
Sbjct: 394 PKKPAPTTPKEPAPTTPKEPAPTTTKE 420
Score = 33.9 bits (76), Expect = 0.59
Identities = 61/325 (18%), Positives = 113/325 (34%), Gaps = 25/325 (7%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
+ +P P P+ A + +P+ P + K+ A + + T
Sbjct: 624 LKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 683
Query: 61 YAGGTASATKVSASSGATSK--------SSSMNPTETKAVKTEPEKKSQSTKLSVVHEKK 112
GTA T + K +++ PT T + K P ++ +
Sbjct: 684 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 743
Query: 113 SQEGKPKEHTEPKSLPKQASDTGS-NDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAG 171
+ KP T P++ P S+ + + +S ++ E S EP K +
Sbjct: 744 TTPKKPAP-TTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKE 802
Query: 172 GESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEET 231
T + KP + K T + + P+ + M +T E+T
Sbjct: 803 PGVPTTKTPAATKP-EMTTTAKDKTTERDLRTTPETTTAAPKMTK------ETATTTEKT 855
Query: 232 EEENTTYTGPEVSD--PMSSTYIEELGKREVTIPPKY---RELLAKKEGITGPPADSSKP 286
E T T +V+ +T + + T+ PK ++ + E I P +++KP
Sbjct: 856 TESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTE-IMNKPEETAKP 914
Query: 287 IGPDDAIDALSSDFTCGSPTAAGKK 311
D A ++ ++ PT A KK
Sbjct: 915 --KDRATNSKATTPKPQKPTKAPKK 937
Score = 32.0 bits (71), Expect = 2.2
Identities = 54/255 (21%), Positives = 93/255 (36%), Gaps = 21/255 (8%)
Query: 521 EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDF 580
E+ +E D + +K + PDY + KD K K+ PP+ + E
Sbjct: 79 ERGRECDCDAQCKKYDKCCPDYESFCAEVKDNKKNRTKKKPTPKPPV--------VDEAG 130
Query: 581 SGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT--SQSDKDLDDALDKLSDS 638
SG N K + VS +P TT PR + SD + +L ++
Sbjct: 131 SGLDN-GDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKET 189
Query: 639 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDT--IPPEYRHLLDDNGQ-DKPVKPP 695
+ + NK KEK + + E+ + P + L + + K P
Sbjct: 190 TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP 249
Query: 696 TKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKC----KKAASSSKAPKNGG 751
+ P ++P A + + P+T +++ T K+ K A ++ K P
Sbjct: 250 ALTTPKEPTPTTPKEP--ASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA-PT 306
Query: 752 KAKDSAKTTEETSKP 766
K+ A TT + P
Sbjct: 307 TTKEPAPTTPKEPAP 321
>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
Length = 1363
Score = 64.3 bits (155), Expect = 4e-10
Identities = 151/754 (20%), Positives = 247/754 (32%), Gaps = 74/754 (9%)
Query: 31 TSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETK 90
TS+ S K+ + E K + + Q+S T SA + + ++K + PT
Sbjct: 229 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD--LAPTSKV 286
Query: 91 AVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAE 150
K P+ ++ + ++ K+ PKE + PK+ + T K A + E
Sbjct: 287 LAKPTPKAETTTKGPALTTPKEPTPTTPKEPAS--TTPKEPTPTTI-----KSAPTTPKE 339
Query: 151 QQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSG 210
P+ + P T P++ + A T P K+ + T + P K P+
Sbjct: 340 PAPTTTKSAPTT-PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPT- 397
Query: 211 KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELL 270
T P T + T P+ P + K PK
Sbjct: 398 -------------TPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT 444
Query: 271 AKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVR 330
A K+ P + + P P + + + + +P T K T + T
Sbjct: 445 APKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 503
Query: 331 SAAPPQEKKRKVEKD----TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKL 386
+ P+E K+ T + A T EP + KE K+
Sbjct: 504 APTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKPAP 561
Query: 387 EKCGEDDETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDRSE 441
E T P E P T K P PE EKP P + EL E+
Sbjct: 562 TTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE----- 614
Query: 442 CKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEAL 498
P+ P E + KAAAP E T + P EPA T K T P +
Sbjct: 615 --PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KGT 671
Query: 499 ADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPK 558
A + K+ A KP ++ +E +K P K P PK
Sbjct: 672 APTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTPK 722
Query: 559 ES-----KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQ 613
E KE P + L E P + K +LA ++ + T +
Sbjct: 723 EPAPTTPKEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKPA 778
Query: 614 AGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDD 673
P + K+ K P P ++ ++ H+ D+
Sbjct: 779 PTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----DE 834
Query: 674 TIPPEYRHLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETSQ 730
+ P ++ P +P PT K+ + KP D + DL + P TT +
Sbjct: 835 STPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAP 894
Query: 731 NTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETS 764
K+ ++++ + ++ TT++T+
Sbjct: 895 KMTKETATTTEKTTESKITATTTQVTSTTTQDTT 928
Score = 59.7 bits (143), Expect = 1e-08
Identities = 157/800 (19%), Positives = 255/800 (31%), Gaps = 98/800 (12%)
Query: 8 PAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKG---------SDEKKAASLGSSQSS 58
P + P ++A + + T SP P +KK ++E + S SS
Sbjct: 69 PTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSS 128
Query: 59 RTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKS----- 113
+ + +++ K+ +S + + + K K KK + K VV E S
Sbjct: 129 SSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNG 188
Query: 114 ------QEGKPKEHTEPKSLPKQASDTGSN-------DAHNKKAVSRSAEQQPSEKSTEP 160
+ +H + + PK + N ++ K S + ++ + ++ E
Sbjct: 189 DFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKET 248
Query: 161 KTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDD 220
T + + G E T+ +K K L P V +KP P ++
Sbjct: 249 TTTNKQTSTDGKEKT---TSAKETQSIEKTSAKDLAPTSKVLAKP-TPKAET-------- 296
Query: 221 LIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPP 280
T GP T + T T P+ +P S+T E + P +E P
Sbjct: 297 ---TTKGPALTTPKEPTPTTPK--EPASTTPKEPTPTTIKSAPTTPKE--------PAPT 343
Query: 281 ADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKR 340
S P P + + + +P T KE + K+ + T + AP K
Sbjct: 344 TTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS-APTTPKEPAPTTPK-- 400
Query: 341 KVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEY 400
K T + A T EP KE E T P
Sbjct: 401 KPAPTTPKEPAPTTPKEPTPTTPKEP-----------APTTKEPAPTTPKEPAPTAPK-- 447
Query: 401 RLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAA 460
+ P T K+ P P ++P P + E ++ + K P+ E + +A
Sbjct: 448 KPAPTTPKEPAPTTP---KEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSA 504
Query: 461 PAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK 518
P E T+ + P EPA T K P E A + K+ A KP
Sbjct: 505 PTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEP-APTTPKEPAPTTTKKPAPTT 563
Query: 519 VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE 578
KE A +E + + P + KP + E+L P + + E
Sbjct: 564 PKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKP--APTTPEELAPTTPEEPTPTTPE 621
Query: 579 DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDS 638
+ P + K A + PA TT P + K+ K +
Sbjct: 622 E-PAPTTPKAAAPNTPKEPA---PTTPKEPAPTT----PKEPAPTTPKETAPTTPKGTAP 673
Query: 639 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPV----KP 694
++P P P + KE A ++ D P +P K
Sbjct: 674 TTLKEPAP--TTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE 731
Query: 695 PTKKSEDSKKPADDQDPIDAL---SGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGG 751
P + P ++P + P+TT+ +T DK AP
Sbjct: 732 PAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPK 791
Query: 752 K-----AKDSAKTTEETSKP 766
+ K A TT ET P
Sbjct: 792 EPAPTTPKKPAPTTPETPPP 811
Score = 47.4 bits (111), Expect = 5e-05
Identities = 129/623 (20%), Positives = 208/623 (33%), Gaps = 97/623 (15%)
Query: 7 KPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTA 66
K A P+ A + +P+ P E + KK A + + T TA
Sbjct: 517 KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETA 576
Query: 67 SATKVSASSGATSKSSSMNP------TETKAVKTEPEKKSQST--KLSVVHEKKSQEGKP 118
T + K + P T + T PE+ + +T + + K + P
Sbjct: 577 PTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP 636
Query: 119 KEH--TEPK----SLPKQASDTGSNDAH--NKKAVSRSAEQQPSEKSTEPKTKPQDMISA 170
KE T PK + PK+ + T + K + + ++P+ +T K P+++
Sbjct: 637 KEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP-TTPKKPAPKELAPT 695
Query: 171 GGESVAGITAISGKP----GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 226
+ T P G K P P E P P G + + T
Sbjct: 696 TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPK 754
Query: 227 GPEETEEENTTYTGPE--VSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSS 284
P E TT GP SD + T +E T P + KK T P
Sbjct: 755 KPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP---TTPKEPAPTTPKKPAPTTPET--- 808
Query: 285 KPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP-----PQEKK 339
P +S+ T PT K + EST L A+ +P P K
Sbjct: 809 ----PPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALENSPKEPGVPTTKT 862
Query: 340 RKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSE 399
K M+ A + + E DLR+ E A K K E ++T S+
Sbjct: 863 PAATKPEMTTTAKDKTT----------ERDLRTTPETTTAAPKMTK-ETATTTEKTTESK 911
Query: 400 Y-----RLKPATDKDGKP----------LLPEPEEKPKPRSESELIDELSEDFDRSECKE 444
++ T +D P L P+ K + +E++++ E
Sbjct: 912 ITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK----------PE 961
Query: 445 KPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ-----------SAPPEPATLKGTVPD- 492
+ +KP ++ SKA P P S + P P + T+P+
Sbjct: 962 ETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPEL 1021
Query: 493 DAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET-----IPPDYRLEEV 547
+ +A+++ + P P V+ K ED G + ET P + E
Sbjct: 1022 NPTSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHMLLRPHVFMPEVT 1078
Query: 548 KDKDGKPLLPKESKEQLPPMSED 570
D D P +P + P +S++
Sbjct: 1079 PDMDYLPRVPNQGIIINPMLSDE 1101
Score = 46.6 bits (109), Expect = 9e-05
Identities = 107/524 (20%), Positives = 175/524 (33%), Gaps = 57/524 (10%)
Query: 12 PRPRRAAAARRTHEHVSEKTSE--SPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASAT 69
P P +A T + S T++ +P+ P E + KK A + + T A T
Sbjct: 496 PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 555
Query: 70 KVSASSGATSKSSSMNPTETKAVKTEPEKKSQST--KLSVVHEKKSQEGKPKE--HTEPK 125
+ + + P ET T P+K + +T KL+ +K P+E T P+
Sbjct: 556 TKKPAPTTPKEPAPTTPKET--APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE 613
Query: 126 SLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKP 185
+ + A + E P+ T P++ + A T P
Sbjct: 614 EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAP 673
Query: 186 GDKKKEKKSLTPAVPVESKPDKPSGKS-GMDAALDDLIDTLGGPEETEEENTTYTGPEVS 244
K+ P + P KP+ K + T P T + T T P+
Sbjct: 674 TTLKE---------PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPK-- 722
Query: 245 DPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGS 304
+P +T E T P K+ T P + K + P S+ +
Sbjct: 723 EPAPTTPKEP----APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPA 778
Query: 305 PTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA 364
PT T KE + K + T + AP + T S+ + + T
Sbjct: 779 PT-----TPKETAPTTPKEPAPTTPKKPAPTTP---ETPPPTTSEVSTPTTTKEPTTIHK 830
Query: 365 EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPR 424
P+ + KA E ++ G P+ KP K E + + P
Sbjct: 831 SPDESTPELSAEPTPKALENSPKEPGVPTTKTPA--ATKPEMTTTAKDKTTERDLRTTPE 888
Query: 425 SESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPA 484
+ + + ++ + TEKT ESK A TS + + P +
Sbjct: 889 TTTA----------APKMTKETATTTEKTTESKITATTTQV-----TSTTTQDTTPFKIT 933
Query: 485 TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 528
TLK T V ++ E +M+K +E AK +DR
Sbjct: 934 TLKTTTLAPKVTTTKKTITTTE--------IMNKPEETAKPKDR 969
>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
Length = 1404
Score = 64.3 bits (155), Expect = 4e-10
Identities = 151/754 (20%), Positives = 247/754 (32%), Gaps = 74/754 (9%)
Query: 31 TSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETK 90
TS+ S K+ + E K + + Q+S T SA + + ++K + PT
Sbjct: 270 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD--LAPTSKV 327
Query: 91 AVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAE 150
K P+ ++ + ++ K+ PKE + PK+ + T K A + E
Sbjct: 328 LAKPTPKAETTTKGPALTTPKEPTPTTPKEPAS--TTPKEPTPTTI-----KSAPTTPKE 380
Query: 151 QQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSG 210
P+ + P T P++ + A T P K+ + T + P K P+
Sbjct: 381 PAPTTTKSAPTT-PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPT- 438
Query: 211 KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELL 270
T P T + T P+ P + K PK
Sbjct: 439 -------------TPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT 485
Query: 271 AKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVR 330
A K+ P + + P P + + + + +P T K T + T
Sbjct: 486 APKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 544
Query: 331 SAAPPQEKKRKVEKD----TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKL 386
+ P+E K+ T + A T EP + KE K+
Sbjct: 545 APTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKPAP 602
Query: 387 EKCGEDDETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDRSE 441
E T P E P T K P PE EKP P + EL E+
Sbjct: 603 TTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE----- 655
Query: 442 CKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEAL 498
P+ P E + KAAAP E T + P EPA T K T P +
Sbjct: 656 --PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KGT 712
Query: 499 ADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPK 558
A + K+ A KP ++ +E +K P K P PK
Sbjct: 713 APTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTPK 763
Query: 559 ES-----KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQ 613
E KE P + L E P + K +LA ++ + T +
Sbjct: 764 EPAPTTPKEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKPA 819
Query: 614 AGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDD 673
P + K+ K P P ++ ++ H+ D+
Sbjct: 820 PTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----DE 875
Query: 674 TIPPEYRHLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETSQ 730
+ P ++ P +P PT K+ + KP D + DL + P TT +
Sbjct: 876 STPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAP 935
Query: 731 NTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETS 764
K+ ++++ + ++ TT++T+
Sbjct: 936 KMTKETATTTEKTTESKITATTTQVTSTTTQDTT 969
Score = 59.7 bits (143), Expect = 1e-08
Identities = 157/800 (19%), Positives = 255/800 (31%), Gaps = 98/800 (12%)
Query: 8 PAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKG---------SDEKKAASLGSSQSS 58
P + P ++A + + T SP P +KK ++E + S SS
Sbjct: 110 PTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSS 169
Query: 59 RTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKS----- 113
+ + +++ K+ +S + + + K K KK + K VV E S
Sbjct: 170 SSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNG 229
Query: 114 ------QEGKPKEHTEPKSLPKQASDTGSN-------DAHNKKAVSRSAEQQPSEKSTEP 160
+ +H + + PK + N ++ K S + ++ + ++ E
Sbjct: 230 DFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKET 289
Query: 161 KTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDD 220
T + + G E T+ +K K L P V +KP P ++
Sbjct: 290 TTTNKQTSTDGKEKT---TSAKETQSIEKTSAKDLAPTSKVLAKP-TPKAET-------- 337
Query: 221 LIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPP 280
T GP T + T T P+ +P S+T E + P +E P
Sbjct: 338 ---TTKGPALTTPKEPTPTTPK--EPASTTPKEPTPTTIKSAPTTPKE--------PAPT 384
Query: 281 ADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKR 340
S P P + + + +P T KE + K+ + T + AP K
Sbjct: 385 TTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS-APTTPKEPAPTTPK-- 441
Query: 341 KVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEY 400
K T + A T EP KE E T P
Sbjct: 442 KPAPTTPKEPAPTTPKEPTPTTPKEP-----------APTTKEPAPTTPKEPAPTAPK-- 488
Query: 401 RLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAA 460
+ P T K+ P P ++P P + E ++ + K P+ E + +A
Sbjct: 489 KPAPTTPKEPAPTTP---KEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSA 545
Query: 461 PAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK 518
P E T+ + P EPA T K P E A + K+ A KP
Sbjct: 546 PTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEP-APTTPKEPAPTTTKKPAPTT 604
Query: 519 VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE 578
KE A +E + + P + KP + E+L P + + E
Sbjct: 605 PKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKP--APTTPEELAPTTPEEPTPTTPE 662
Query: 579 DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDS 638
+ P + K A + PA TT P + K+ K +
Sbjct: 663 E-PAPTTPKAAAPNTPKEPA---PTTPKEPAPTT----PKEPAPTTPKETAPTTPKGTAP 714
Query: 639 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPV----KP 694
++P P P + KE A ++ D P +P K
Sbjct: 715 TTLKEPAP--TTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE 772
Query: 695 PTKKSEDSKKPADDQDPIDAL---SGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGG 751
P + P ++P + P+TT+ +T DK AP
Sbjct: 773 PAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPK 832
Query: 752 K-----AKDSAKTTEETSKP 766
+ K A TT ET P
Sbjct: 833 EPAPTTPKKPAPTTPETPPP 852
Score = 47.4 bits (111), Expect = 5e-05
Identities = 129/623 (20%), Positives = 208/623 (33%), Gaps = 97/623 (15%)
Query: 7 KPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTA 66
K A P+ A + +P+ P E + KK A + + T TA
Sbjct: 558 KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETA 617
Query: 67 SATKVSASSGATSKSSSMNP------TETKAVKTEPEKKSQST--KLSVVHEKKSQEGKP 118
T + K + P T + T PE+ + +T + + K + P
Sbjct: 618 PTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP 677
Query: 119 KEH--TEPK----SLPKQASDTGSNDAH--NKKAVSRSAEQQPSEKSTEPKTKPQDMISA 170
KE T PK + PK+ + T + K + + ++P+ +T K P+++
Sbjct: 678 KEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP-TTPKKPAPKELAPT 736
Query: 171 GGESVAGITAISGKP----GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 226
+ T P G K P P E P P G + + T
Sbjct: 737 TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPK 795
Query: 227 GPEETEEENTTYTGPE--VSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSS 284
P E TT GP SD + T +E T P + KK T P
Sbjct: 796 KPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP---TTPKEPAPTTPKKPAPTTPET--- 849
Query: 285 KPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP-----PQEKK 339
P +S+ T PT K + EST L A+ +P P K
Sbjct: 850 ----PPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALENSPKEPGVPTTKT 903
Query: 340 RKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSE 399
K M+ A + + E DLR+ E A K K E ++T S+
Sbjct: 904 PAATKPEMTTTAKDKTT----------ERDLRTTPETTTAAPKMTK-ETATTTEKTTESK 952
Query: 400 Y-----RLKPATDKDGKP----------LLPEPEEKPKPRSESELIDELSEDFDRSECKE 444
++ T +D P L P+ K + +E++++ E
Sbjct: 953 ITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK----------PE 1002
Query: 445 KPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ-----------SAPPEPATLKGTVPD- 492
+ +KP ++ SKA P P S + P P + T+P+
Sbjct: 1003 ETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPEL 1062
Query: 493 DAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET-----IPPDYRLEEV 547
+ +A+++ + P P V+ K ED G + ET P + E
Sbjct: 1063 NPTSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHMLLRPHVFMPEVT 1119
Query: 548 KDKDGKPLLPKESKEQLPPMSED 570
D D P +P + P +S++
Sbjct: 1120 PDMDYLPRVPNQGIIINPMLSDE 1142
Score = 46.6 bits (109), Expect = 9e-05
Identities = 107/524 (20%), Positives = 175/524 (33%), Gaps = 57/524 (10%)
Query: 12 PRPRRAAAARRTHEHVSEKTSE--SPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASAT 69
P P +A T + S T++ +P+ P E + KK A + + T A T
Sbjct: 537 PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 596
Query: 70 KVSASSGATSKSSSMNPTETKAVKTEPEKKSQST--KLSVVHEKKSQEGKPKE--HTEPK 125
+ + + P ET T P+K + +T KL+ +K P+E T P+
Sbjct: 597 TKKPAPTTPKEPAPTTPKET--APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPE 654
Query: 126 SLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKP 185
+ + A + E P+ T P++ + A T P
Sbjct: 655 EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAP 714
Query: 186 GDKKKEKKSLTPAVPVESKPDKPSGKS-GMDAALDDLIDTLGGPEETEEENTTYTGPEVS 244
K+ P + P KP+ K + T P T + T T P+
Sbjct: 715 TTLKE---------PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPK-- 763
Query: 245 DPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGS 304
+P +T E T P K+ T P + K + P S+ +
Sbjct: 764 EPAPTTPKEP----APTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPA 819
Query: 305 PTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA 364
PT T KE + K + T + AP + T S+ + + T
Sbjct: 820 PT-----TPKETAPTTPKEPAPTTPKKPAPTTP---ETPPPTTSEVSTPTTTKEPTTIHK 871
Query: 365 EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPR 424
P+ + KA E ++ G P+ KP K E + + P
Sbjct: 872 SPDESTPELSAEPTPKALENSPKEPGVPTTKTPA--ATKPEMTTTAKDKTTERDLRTTPE 929
Query: 425 SESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPA 484
+ + + ++ + TEKT ESK A TS + + P +
Sbjct: 930 TTTA----------APKMTKETATTTEKTTESKITATTTQV-----TSTTTQDTTPFKIT 974
Query: 485 TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 528
TLK T V ++ E +M+K +E AK +DR
Sbjct: 975 TLKTTTLAPKVTTTKKTITTTE--------IMNKPEETAKPKDR 1010
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 64.3 bits (155), Expect = 4e-10
Identities = 94/467 (20%), Positives = 167/467 (35%), Gaps = 71/467 (15%)
Query: 10 ASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTY----AGGT 65
A P+P RAA + S +S S S + S+E+KAA+ + A
Sbjct: 198 APPKPARAAPKIANGKAASSSSSSSSSSSSDD--SEEEKAAATPKKTVPKKQVVAKAPVK 255
Query: 66 ASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK 125
A+ T SS + SS + K +K +P S S KKS +P + K
Sbjct: 256 AATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEK 315
Query: 126 SLPKQASDTGSNDAHN----------KKAVSRSAEQQP-SEKSTEPKTKPQDMISAGGES 174
P ++S+ S+++ + K VS++ + P ++K+ E + D S+ +
Sbjct: 316 QQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDE 375
Query: 175 VAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEE 234
A + K K + +PAV + P +P G L+ +EEE
Sbjct: 376 APSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGG------QKLLTRKADSSSSEEE 429
Query: 235 NTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAID 294
+++ + +++T + K +++P K P G D+
Sbjct: 430 SSSSEEEKTKKMVATTKPKATAKAALSLPAK------------------QAPQGSRDS-- 469
Query: 295 ALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEA 354
SSD S +KT K + + + AG + P KK K E S
Sbjct: 470 --SSDSDSSSSEEEEEKTSKS-AVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSD--- 523
Query: 355 LSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLL 414
D ++ +EEKL+ G P T ++GK
Sbjct: 524 ----------------------DSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAK 561
Query: 415 PEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAP 461
EE+ + + + ++ + R + + T + ++ K P
Sbjct: 562 NSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTP 608
Score = 58.9 bits (141), Expect = 2e-08
Identities = 133/623 (21%), Positives = 218/623 (34%), Gaps = 144/623 (23%)
Query: 63 GGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHT 122
G A K ASS + SS E + V+ P KK+ V G P
Sbjct: 72 GPVAKKAKKKASSSDSEDSSE----EEEEVQGPPAKKAAVPAKRV--------GLP---- 115
Query: 123 EPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAIS 182
P +AS++ S++ + ++QP +K +P+ K +S + S
Sbjct: 116 -PGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSS 174
Query: 183 GKPGDKKKEKKSLTPA-VPVESK-PDKPSGKS-----GMDAALDDLIDTLGGPEETEEEN 235
+ K +K +TP V ++K P KP+ + G A+ + +++EEE
Sbjct: 175 SEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEK 234
Query: 236 TTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDA 295
T + T+P K +++AK P ++ P + +
Sbjct: 235 AAATPKK------------------TVPKK--QVVAK-----APVKAATTPTRKSSSSED 269
Query: 296 LSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEAL 355
SSD E+EE + +K G S PP K
Sbjct: 270 SSSD-------------EEEEQKKPMK-NKPGPYSSVPPPSAPPPK-------------- 301
Query: 356 SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP 415
SLGT+ + K V++ + E + E D + SE KP T K ++
Sbjct: 302 -KSLGTQPPK--------KAVEKQQPVESSEDSSDESDSS--SEEEKKPPT----KAVVS 346
Query: 416 EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCS 475
+ KP P ++ S D D SE E PSKP T+ S + PA +++
Sbjct: 347 KATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNS-SNKPAVTTKS-------- 397
Query: 476 IQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKE 535
PA P V G+ ++ + + + E+ E+E
Sbjct: 398 -------PAVKPAAAPKQPVGG--------------GQKLLTRKADSSSSEEESSSSEEE 436
Query: 536 ETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLD---ALSEDFSGPQNASSLKFE 592
+T + K K +Q P S D D + SE+ + S++K +
Sbjct: 437 KT---KKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKK 493
Query: 593 DAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDEN--- 649
K+A PAS + A ++S SD ++ +KL R P N
Sbjct: 494 PQKVAGG---AAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTS 550
Query: 650 ----------KPMEDKVKEKAKA 662
K E++ +EK KA
Sbjct: 551 ALTAQNGKAAKNSEEEEEEKKKA 573
Score = 55.8 bits (133), Expect = 1e-07
Identities = 84/379 (22%), Positives = 139/379 (36%), Gaps = 67/379 (17%)
Query: 439 RSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEAL 498
+++ K S + +EE + P +A + PP A K + + E+
Sbjct: 77 KAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGL---PPGKAAAKASESSSSEESS 133
Query: 499 ADSLGKKEADPEDGK--PVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 556
D D ED K PV VK +AK K D E+ K+ KP +
Sbjct: 134 DDD------DEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKI 187
Query: 557 -----------PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVS 605
P + P ++ A S S ++SS E+ K AA + V
Sbjct: 188 TPVTVKAQTKAPPKPARAAPKIANG---KAASSSSSSSSSSSSDDSEEEKAAATPKKTVP 244
Query: 606 Q----TPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQ-----------PDPDEN- 649
+ A A P R +S S+ D ++ + + P P ++
Sbjct: 245 KKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSL 304
Query: 650 --KPMEDKVKEKAKAEHRDKLGERDDTIPPEYRH----LLDDNGQDKPVKPPTKKSEDSK 703
+P + V+++ E + + D+ E + + KP PP KK+ +S
Sbjct: 305 GTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKP--PPAKKAAESS 362
Query: 704 KPADDQDPIDALSGDLDSCPS----TTETSQN----TAKDKCKKAASSSKAPKNGG---- 751
+ D D S + D PS TT+ S N T K K A++ K P GG
Sbjct: 363 SDSSDSD-----SSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLL 417
Query: 752 -KAKDSAKTTEETSKPKDD 769
+ DS+ + EE+S +++
Sbjct: 418 TRKADSSSSEEESSSSEEE 436
Score = 51.2 bits (121), Expect = 4e-06
Identities = 102/480 (21%), Positives = 172/480 (35%), Gaps = 73/480 (15%)
Query: 3 QPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYA 62
Q G KP A A+ + + + P K + K + A + A
Sbjct: 147 QKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAA 206
Query: 63 GGTASATKVSASSGATSKSSSMNPTETKAVKTE--------------------PEKKSQS 102
A+ S+SS ++S SSS + E KA T P +KS S
Sbjct: 207 PKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSS 266
Query: 103 TKLSVVHE----KKSQEGKPKEH----------------TEP--KSLPKQASDTGSNDAH 140
++ S E KK + KP + T+P K++ KQ S D+
Sbjct: 267 SEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSS 326
Query: 141 NKKAVSRSAEQQPSEKSTEPK--TKP-------------QDMISAGGESVAGITAISGKP 185
++ S E++P K+ K TKP D S+ + A + K
Sbjct: 327 DESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKN 386
Query: 186 GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSD 245
K + +PAV + P +P G L+ +EEE+++ +
Sbjct: 387 SSNKPAVTTKSPAVKPAAAPKQPVGGG------QKLLTRKADSSSSEEESSSSEEEKTKK 440
Query: 246 PMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSP 305
+++T + K +++P K +G +DS ++ + S P
Sbjct: 441 MVATTKPKATAKAALSLPAK-----QAPQGSRDSSSDSDSSSSEEEE-EKTSKSAVKKKP 494
Query: 306 --TAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE-KDTMSDQALEALSASLGTR 362
A G K S + KA+S+ + S +E++ K++ K + QA +A S T
Sbjct: 495 QKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTA 554
Query: 363 QAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPK 422
Q + S +E +E K + K G + +E + T + K L P PK
Sbjct: 555 Q-NGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPK 613
Score = 50.4 bits (119), Expect = 6e-06
Identities = 122/544 (22%), Positives = 203/544 (37%), Gaps = 73/544 (13%)
Query: 30 KTSESPSKPGEKKGSDEKKAASLGSSQSSRTYA-------GGTASATKVSAS-------S 75
K+++ P + + G KKA SS S + G A V A
Sbjct: 59 KSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGK 118
Query: 76 GATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTG 135
A S S + E+ E ++K Q + V + K+ + PK+ S SD+
Sbjct: 119 AAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDS----DSDSS 174
Query: 136 SNDA---HNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEK 192
S D + K ++ + ++ +P + + S + ++ S D ++EK
Sbjct: 175 SEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEK 234
Query: 193 KSLTPAVPVESK------PDK----PSGKSGM--DAALDDLIDTLGGPEETEEENTTYTG 240
+ TP V K P K P+ KS D++ D+ EE ++ G
Sbjct: 235 AAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDE-------EEEQKKPMKNKPG 287
Query: 241 PEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGI-----TGPPADSSKPIGPDDAIDA 295
P S P S + K T PPK + + K++ + + +DSS A
Sbjct: 288 PYSSVPPPSAPPPK--KSLGTQPPK--KAVEKQQPVESSEDSSDESDSSSEEEKKPPTKA 343
Query: 296 LSSDFTCGSPTA-----AGKKTEKEESTEVLKAQS--AGTVRSAA--PPQEKKRKVEKDT 346
+ S T P A + + +S+E +A S AGT ++++ P K K
Sbjct: 344 VVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPA 403
Query: 347 MSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPAT 406
+ + L TR+A+ S E + + ++EEK +K T + K A
Sbjct: 404 AAPKQPVGGGQKLLTRKAD-----SSSSEEESSSSEEEKTKKM---VATTKPKATAKAAL 455
Query: 407 DKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSE 466
K P+ S+S +E E +S K+KP K SK A+ A +
Sbjct: 456 SLPAKQ-APQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPAS-AKKGK 513
Query: 467 AVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEE 526
A S S S+ E LKG A+ G ++GK + +E EE
Sbjct: 514 AESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKAN--GTSALTAQNGKAAKNSEEE---EE 568
Query: 527 DREK 530
+++K
Sbjct: 569 EKKK 572
Score = 35.8 bits (81), Expect = 0.15
Identities = 34/141 (24%), Positives = 54/141 (38%), Gaps = 13/141 (9%)
Query: 6 QKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGT 65
QK A P + A+A++ S +S S E E+K GS + A GT
Sbjct: 495 QKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEE-----EEKLKGKGSPRPQAPKANGT 549
Query: 66 ASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK 125
++ T A +G +K+S E K K S+ K+++ K E + K
Sbjct: 550 SALT---AQNGKAAKNSEEEEEEKKKAAVVVSKSG-----SLKKRKQNEAAKEAETPQAK 601
Query: 126 SLPKQASDTGSNDAHNKKAVS 146
+ Q +T +K S
Sbjct: 602 KIKLQTPNTFPKRKKGEKRAS 622
>gi|109637791 transcription factor-like nuclear regulator [Homo
sapiens]
Length = 2624
Score = 63.9 bits (154), Expect = 5e-10
Identities = 132/610 (21%), Positives = 230/610 (37%), Gaps = 90/610 (14%)
Query: 74 SSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASD 133
S G T S + ++T K EK +T L ++ + ++ P+ T K
Sbjct: 633 SQGKTESESKNSHSKTSVEKNHVEKDKMNT-LDILRMETTERENPEAETVSVLGEKNCLQ 691
Query: 134 TGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKK 193
GS + R Q+P + + + + +IS E A + +K E +
Sbjct: 692 EGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQE-EIGANV---------EKNENE 741
Query: 194 SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEE-ENTTYTGPEVSDPMSSTYI 252
S P +S D +D+I PE+ + +N P+V + S
Sbjct: 742 SCAD----RDTPQHMEDQSRKDFEEEDVILQ---PEKNDSFQNVQPDEPKVLNECLSVQE 794
Query: 253 EELGKREVTIPPKYRELLAKKEGI---TGPPADSSKPIGPDDAIDALSSDFTCGSPTAAG 309
+ +P K I TG SSK + L G AA
Sbjct: 795 NNKANKLNQVPILRTRFQKPKPNIGRGTGRREISSKE-------EVLEKILVSGEMAAAL 847
Query: 310 KKTEK-----------EESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMS-DQALEALSA 357
++T + E +T+ +++ T R A P+EK V DT+ + L+A+
Sbjct: 848 RETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGR 907
Query: 358 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 417
+ R+ PE+ +D + ++ LE+ G R + + K+G P
Sbjct: 908 EICLREKTPEV-------IDATEEIDKDLEEAG----------RREISPQKNG------P 944
Query: 418 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 477
EE KP E E +L + S +EK + T+ TEE + + + T I
Sbjct: 945 EEV-KPLGEVET--DLKATGNESSPREKTPEVTDATEE--------IDKNLEETGRRKIS 993
Query: 478 SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET 537
P +K P D +E ++ G++ + E V+D +E EE + E
Sbjct: 994 PRENGPEEVK---PVDEMETDLNATGRESSPREKTPEVIDATEEIDLEET------EREV 1044
Query: 538 IPPDYRLEEVKDK-DGKPLLPKESKEQLPPMSEDFLLDALSE---DFSGPQNASSLKFED 593
P + LEEVK + + L ++ P ++DA+ E D + S +
Sbjct: 1045 SPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENG 1104
Query: 594 AKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPME 653
+ + E+ QT T PR+ + D + +DK + G+R+ P+EN P E
Sbjct: 1105 LEEVKPLGEM--QTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEE 1162
Query: 654 DKVKEKAKAE 663
K ++ + +
Sbjct: 1163 VKPVDEMETD 1172
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 63.5 bits (153), Expect = 7e-10
Identities = 169/831 (20%), Positives = 308/831 (37%), Gaps = 100/831 (12%)
Query: 4 PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAAS---LGSSQSSRT 60
PG+ +P + A A +T E+ SES S+ E S+E+ A+ L + S +T
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSE--ESSDSEEETPAAKALLQAKASGKT 368
Query: 61 YAGGTASA-TKVSASSGAT-SKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKS----- 113
G ASA K S GA + P KA + E+ SQS+ E+++
Sbjct: 369 SQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAK 428
Query: 114 QEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGE 173
GK + + K++ G+ A +K +A+ Q ++ + ++ ++ + E
Sbjct: 429 PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES-DSDRE 487
Query: 174 SVAGITAISGKPGDKKKEKKSLTPAVPVESKP------DKPSGKSGMDAALDDLIDTLGG 227
++A + A KP K + K PA + P P GK G +
Sbjct: 488 ALAAMNAAQVKPLGKSPQVK---PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEED 544
Query: 228 PEETEEENTTYTGPEVSDPMSSTYIEELGK----REVTIPPKYRELLAKKEGITGPPADS 283
E + EE++ + EV ++ + LG + + P K +K G +
Sbjct: 545 SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGP---PQKAGPVAVQVKA 601
Query: 284 SKPI----GPDDAIDALSSDFTCGSPTAA-GKKTEKEESTEVLKAQSAGTVRSAAPPQEK 338
KP+ +++ D+ S+ + TAA K K T+ ++ T + P
Sbjct: 602 EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRV 661
Query: 339 KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE------EKLEKCGED 392
+ + + + S ++ P D S +E D + K + + G+
Sbjct: 662 GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKG 721
Query: 393 DETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK 452
+ + +K + + P+LP K P + +++ E ED + SE E
Sbjct: 722 LQVKAASVPVKGSLGQGTAPVLP---GKTGP-TVTQVKAEKQEDSESSE--------EES 769
Query: 453 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTV--PDDAVEALADSLGKKEAD-- 508
E AA+PA V +V +T + +A P+ KGT+ P V A A + + +
Sbjct: 770 DSEEAAASPAQVKTSVKKTQAKANPAAARAPSA-KGTISAPGKVVTAAAQAKQRSPSKVK 828
Query: 509 -------------------PEDGKPVMDKVK-EKAKEEDREKLGEKEETIPPDYRLEEVK 548
P GK V + + EED E+ ++ L +VK
Sbjct: 829 PPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVK 888
Query: 549 DKDGKPLLPKESKEQLPPMSEDFLLDA--LSEDFSGPQNASSLKFEDAKLAAAISEVVSQ 606
GK + + L P E A +GP A + K +D+ ++ S+ +
Sbjct: 889 -PSGK---THQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGE 944
Query: 607 TPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 666
PA+ T A D + A + + Q P + + E + + +
Sbjct: 945 APAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDE 1004
Query: 667 KLGERDDTIPPEYRHLLDDNGQDKPVKPP------------TKKSEDSKKPADDQDPIDA 714
+ + P R + P P + + D KK +D+
Sbjct: 1005 DVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDS 1064
Query: 715 LSGDL--DSCPSTTETSQNT---AKDKCKKAASSSKAPKNGGKAKDSAKTT 760
G L S ST+ ++ T K K + ++KAP++ ++DS+ ++
Sbjct: 1065 AVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSS 1115
Score = 60.1 bits (144), Expect = 8e-09
Identities = 158/781 (20%), Positives = 263/781 (33%), Gaps = 118/781 (15%)
Query: 35 PSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKT 94
P+ P + G E+ + S SS+ S + G A + PT + A
Sbjct: 531 PATPSAQVGKWEEDSES--SSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPA--K 586
Query: 95 EPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPS 154
P +K+ + V EK P +++E +++SD S D+ A +A+ +P+
Sbjct: 587 GPPQKAGPVAVQVKAEK------PMDNSESS---EESSD--SADSEEAPAAMTAAQAKPA 635
Query: 155 EKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGM 214
K + K P+ + VA + + P +K+ T P S P G
Sbjct: 636 LKIPQTKACPKKTNTTASAKVAPVRVGTQAP------RKAGTATSPAGSSPAVAGGTQRP 689
Query: 215 DAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPK------YRE 268
D+ E EE T G V+ + + + L + ++P K
Sbjct: 690 AE------DSSSSEESDSEEEKT--GLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAP 741
Query: 269 LLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPT---AAGKKTEKEESTEVLKAQS 325
+L K G T + K + + + S+ SP + KKT+ + + +A S
Sbjct: 742 VLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPS 801
Query: 326 A-GTVRS-----AAPPQEKKR---KVEKDTMSDQALEALS-------------ASLGTRQ 363
A GT+ + A Q K+R KV+ + Q L+ A+ Q
Sbjct: 802 AKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQ 861
Query: 364 AEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKP 423
PE D S +E +++ + E L + +T L PA + K P P K P
Sbjct: 862 TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP 921
Query: 424 RSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEP 483
+ K+ S + + +S APA V+ A Q P P
Sbjct: 922 SAAQA-------------GKQDDSGSSSEESDSDGEAPAAVTSA---------QVIKP-P 958
Query: 484 ATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYR 543
A A + + + P + + + E + E + + + P R
Sbjct: 959 LIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIR 1018
Query: 544 LEEVKDKDGKP-LLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISE 602
V P + PK S E +S+ A+ + L A +
Sbjct: 1019 TNVVTMPTAHPRIAPKASMAGASSSKES---SRISDGKKQEGPATQVDSAVGTLPATSPQ 1075
Query: 603 VVSQTPASTTQAGAPP----RDTSQSDKDLDDALDKLSDSLGQRQPD--PDENKPMEDKV 656
S T + P + +++ + DD+ D S G + P K V
Sbjct: 1076 STSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLV 1135
Query: 657 -----KEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDP 711
+ + E DD + P L +G P P P
Sbjct: 1136 GPTPSRTETLVEETAAESSEDDVVAPSQSLL---SGYMTPGLTPANSQASKATPK----- 1187
Query: 712 IDALSGDLDSCPSTTET----SQNTAKDKCK-KAASSSKAPKNGGKAKDSAKTTEETSKP 766
LDS PS + T K + K + A+ +PK GGK S T +++ KP
Sbjct: 1188 -------LDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKP 1240
Query: 767 K 767
K
Sbjct: 1241 K 1241
Score = 43.9 bits (102), Expect = 6e-04
Identities = 83/404 (20%), Positives = 144/404 (35%), Gaps = 83/404 (20%)
Query: 2 SQPGQKPAASPRPR--RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQ--- 56
S G PA SP+ +A + + + ++ P S++ +S GS +
Sbjct: 1064 SAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGE 1123
Query: 57 ------SSRTYAGGTASATKVSASSGATSKSSS-----------------MNPTETKAVK 93
S+ T G T S T+ A S + P ++A K
Sbjct: 1124 GPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASK 1183
Query: 94 TEPEKKSQSTKLSVVHEKKS----QEGKPKEHT---EPKSLPKQASDTGSNDAHNKKAVS 146
P+ S + S + K QE KP++ PK+ K+A+ +G+ ++K
Sbjct: 1184 ATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAA-SGTTPQKSRKPKK 1242
Query: 147 RSAEQQPSEKSTE------------PKTKPQ----------DMISAGGESVAGITAISGK 184
+ Q S + + P + Q +++ + V T S +
Sbjct: 1243 GAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSR 1302
Query: 185 PG--DKKKEKKSLTPAV--PVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 240
G +K++ PA P K K G +A++ PE+T +TT G
Sbjct: 1303 KGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVS--------PEKT---STTSKG 1351
Query: 241 PEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDF 300
D S E+ GK L + P + K +G + D +
Sbjct: 1352 KAKRDKASGDVKEKKGKGS----------LGSQGAKDEPEEELQKGMGTVEGGDQSNPKS 1401
Query: 301 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEK 344
+ +K +KE+ + KA+ A T S +P Q+KK+K +K
Sbjct: 1402 KKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKK 1445
Score = 43.1 bits (100), Expect = 0.001
Identities = 93/447 (20%), Positives = 159/447 (35%), Gaps = 53/447 (11%)
Query: 353 EALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLE-KCGEDDETIPSEYRLKPATDKDGK 411
+A S+S T + E D+ V A+ K + K + P+ ++ T +
Sbjct: 195 QADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKG 254
Query: 412 PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPS-KPTEKTEESKAA-APAPVSEAVC 469
LP + KP ESE +E SE + + + K +EK + +AA APA +
Sbjct: 255 GALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPG-- 312
Query: 470 RTSMCSIQSAPPEPATLKGTVPDDA----VEALADSLGKKEADPEDGKPVMDKVKEKAKE 525
+ A P P G V E ++S ++ +D E+ P + +
Sbjct: 313 -------KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 365
Query: 526 EDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQN 585
++G R GK P +K Q ED + D
Sbjct: 366 GKTSQVGAASAPAKESPRKGAAPAPPGK-TGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424
Query: 586 ASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTS------QSDKDLDDALDKLSDSL 639
A + A A S ++P A APPR T Q K +D+ +S
Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGA-APAPPRKTGPAAAQVQVGKQEEDSRSSSEESD 483
Query: 640 GQRQP----DPDENKPMEDKVKEK-AKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKP 694
R+ + + KP+ + K A LG+ +PP G+ P P
Sbjct: 484 SDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPP---------GKVGPATP 534
Query: 695 PT---KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPK--- 748
K EDS+ +++ D+ G++ + + + + K +S +K P
Sbjct: 535 SAQVGKWEEDSESSSEESS--DSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA 592
Query: 749 -------NGGKAKDSAKTTEETSKPKD 768
K D+++++EE+S D
Sbjct: 593 GPVAVQVKAEKPMDNSESSEESSDSAD 619
Score = 43.1 bits (100), Expect = 0.001
Identities = 162/842 (19%), Positives = 290/842 (34%), Gaps = 97/842 (11%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
M+ KPA P+ A ++T+ S K + P + G + + K + + SS
Sbjct: 627 MTAAQAKPALKI-PQTKACPKKTNTTASAKVA--PVRVGTQ--APRKAGTATSPAGSSPA 681
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
AGGT + S+SS + S +T T + KS L V +G +
Sbjct: 682 VAGGTQRPAEDSSSS----EESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 737
Query: 121 HTEP-------------KSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDM 167
T P K+ ++ S++ ++ +++A + A+ + S K T+ K P
Sbjct: 738 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA-- 795
Query: 168 ISAGGESVAGITAISGKPGDKKKEKKSLTPAV---PVESKPDK------PSGKSGMDAAL 218
+A S G + GK + K +P+ PV + + P+ + A+
Sbjct: 796 -AARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAV 854
Query: 219 DDLIDTLGGPEE----TEEENTTYTGPEVS---DPMSSTYI---------EELGKREVTI 262
GPEE +EEE+ + E P T+ E K
Sbjct: 855 ATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT 914
Query: 263 PPKYRELLAKKEGITGPPADSSKPIGPD-DAIDALSSDFTCGSPT--AAGKKTEKEESTE 319
PP A + G SS+ D +A A++S P ++ +
Sbjct: 915 PPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAAT 974
Query: 320 VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEA---LSASLGTR-----QAEPELDLR 371
+AQ+A T R A + R ++ + + A L+ + T A P + +
Sbjct: 975 PAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPK 1034
Query: 372 -------SIKE---VDEAKAKEEKLEKCGEDDETIPSEYRLKPA-----TDKDGKPLLPE 416
S KE + + K +E + T+P+ + T+K KP LPE
Sbjct: 1035 ASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPE 1094
Query: 417 PEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSI 476
++ K S+ ++ S+ SE + + + P+ V T+ S
Sbjct: 1095 VQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESS 1154
Query: 477 QS--APPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEK 534
+ P + L G + A +S K D P + + D ++ +
Sbjct: 1155 EDDVVAPSQSLLSGYMTPGLTPA--NSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKP 1212
Query: 535 EET---IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDA-LSEDFSG---PQNAS 587
++ + P +E K K P + L + +++ G P N +
Sbjct: 1213 QQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEA 1272
Query: 588 SLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDA------LDKLSDSLGQ 641
++ K+ + E + TT+ + S+ K D K LG
Sbjct: 1273 QVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGA 1332
Query: 642 RQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSED 701
+ P + K KA+ RDK D + + L G + +K
Sbjct: 1333 GEGGEASVSPEKTSTTSKGKAK-RDKAS--GDVKEKKGKGSLGSQGAKDEPEEELQKGMG 1389
Query: 702 SKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTE 761
+ + D +P + S + + K K KKA++ + K K KT E
Sbjct: 1390 TVEGGDQSNP-KSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAE 1448
Query: 762 ET 763
+T
Sbjct: 1449 QT 1450
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 63.5 bits (153), Expect = 7e-10
Identities = 169/831 (20%), Positives = 308/831 (37%), Gaps = 100/831 (12%)
Query: 4 PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAAS---LGSSQSSRT 60
PG+ +P + A A +T E+ SES S+ E S+E+ A+ L + S +T
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSE--ESSDSEEETPAAKALLQAKASGKT 368
Query: 61 YAGGTASA-TKVSASSGAT-SKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKS----- 113
G ASA K S GA + P KA + E+ SQS+ E+++
Sbjct: 369 SQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAK 428
Query: 114 QEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGE 173
GK + + K++ G+ A +K +A+ Q ++ + ++ ++ + E
Sbjct: 429 PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES-DSDRE 487
Query: 174 SVAGITAISGKPGDKKKEKKSLTPAVPVESKP------DKPSGKSGMDAALDDLIDTLGG 227
++A + A KP K + K PA + P P GK G +
Sbjct: 488 ALAAMNAAQVKPLGKSPQVK---PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEED 544
Query: 228 PEETEEENTTYTGPEVSDPMSSTYIEELGK----REVTIPPKYRELLAKKEGITGPPADS 283
E + EE++ + EV ++ + LG + + P K +K G +
Sbjct: 545 SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGP---PQKAGPVAVQVKA 601
Query: 284 SKPI----GPDDAIDALSSDFTCGSPTAA-GKKTEKEESTEVLKAQSAGTVRSAAPPQEK 338
KP+ +++ D+ S+ + TAA K K T+ ++ T + P
Sbjct: 602 EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRV 661
Query: 339 KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE------EKLEKCGED 392
+ + + + S ++ P D S +E D + K + + G+
Sbjct: 662 GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKG 721
Query: 393 DETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK 452
+ + +K + + P+LP K P + +++ E ED + SE E
Sbjct: 722 LQVKAASVPVKGSLGQGTAPVLP---GKTGP-TVTQVKAEKQEDSESSE--------EES 769
Query: 453 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTV--PDDAVEALADSLGKKEAD-- 508
E AA+PA V +V +T + +A P+ KGT+ P V A A + + +
Sbjct: 770 DSEEAAASPAQVKTSVKKTQAKANPAAARAPSA-KGTISAPGKVVTAAAQAKQRSPSKVK 828
Query: 509 -------------------PEDGKPVMDKVK-EKAKEEDREKLGEKEETIPPDYRLEEVK 548
P GK V + + EED E+ ++ L +VK
Sbjct: 829 PPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVK 888
Query: 549 DKDGKPLLPKESKEQLPPMSEDFLLDA--LSEDFSGPQNASSLKFEDAKLAAAISEVVSQ 606
GK + + L P E A +GP A + K +D+ ++ S+ +
Sbjct: 889 -PSGK---THQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGE 944
Query: 607 TPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 666
PA+ T A D + A + + Q P + + E + + +
Sbjct: 945 APAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDE 1004
Query: 667 KLGERDDTIPPEYRHLLDDNGQDKPVKPP------------TKKSEDSKKPADDQDPIDA 714
+ + P R + P P + + D KK +D+
Sbjct: 1005 DVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDS 1064
Query: 715 LSGDL--DSCPSTTETSQNT---AKDKCKKAASSSKAPKNGGKAKDSAKTT 760
G L S ST+ ++ T K K + ++KAP++ ++DS+ ++
Sbjct: 1065 AVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSS 1115
Score = 60.1 bits (144), Expect = 8e-09
Identities = 160/788 (20%), Positives = 267/788 (33%), Gaps = 133/788 (16%)
Query: 35 PSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKT 94
P+ P + G E+ + S SS+ S + G A + PT + A
Sbjct: 531 PATPSAQVGKWEEDSES--SSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPA--K 586
Query: 95 EPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPS 154
P +K+ + V EK P +++E +++SD S D+ A +A+ +P+
Sbjct: 587 GPPQKAGPVAVQVKAEK------PMDNSESS---EESSD--SADSEEAPAAMTAAQAKPA 635
Query: 155 EKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGM 214
K + K P+ + VA + + P +K+ T P S P G
Sbjct: 636 LKIPQTKACPKKTNTTASAKVAPVRVGTQAP------RKAGTATSPAGSSPAVAGGTQRP 689
Query: 215 DAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPK------YRE 268
D+ E EE T G V+ + + + L + ++P K
Sbjct: 690 AE------DSSSSEESDSEEEKT--GLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAP 741
Query: 269 LLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPT---AAGKKTEKEESTEVLKAQS 325
+L K G T + K + + + S+ SP + KKT+ + + +A S
Sbjct: 742 VLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPS 801
Query: 326 A-GTVRS-----AAPPQEKKR---KVEKDTMSDQALEALS-------------ASLGTRQ 363
A GT+ + A Q K+R KV+ + Q L+ A+ Q
Sbjct: 802 AKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQ 861
Query: 364 AEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKP 423
PE D S +E +++ + E L + +T L PA + K P P K P
Sbjct: 862 TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP 921
Query: 424 RSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEP 483
+ K+ S + + +S APA V+ A Q P P
Sbjct: 922 SAAQA-------------GKQDDSGSSSEESDSDGEAPAAVTSA---------QVIKP-P 958
Query: 484 ATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYR 543
A A + + + P + + + E + E + + + P R
Sbjct: 959 LIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIR 1018
Query: 544 LEEVKDKDGKP-LLPKES-----------------KEQLPPMSEDFLLDALSEDFSGPQN 585
V P + PK S K++ P D + L + PQ+
Sbjct: 1019 TNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPA--TSPQS 1076
Query: 586 ASSLKFEDAKLAAA-ISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQP 644
S KL + EV T A + + S S + D + + S P
Sbjct: 1077 TSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGP 1136
Query: 645 DPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKK 704
P + + ++ ++ DD + P L +G P P
Sbjct: 1137 TPSRTETLVEETAAESS---------EDDVVAPSQSLL---SGYMTPGLTPANSQASKAT 1184
Query: 705 PADDQDPIDALSGDLDSCPSTTET----SQNTAKDKCK-KAASSSKAPKNGGKAKDSAKT 759
P LDS PS + T K + K + A+ +PK GGK S T
Sbjct: 1185 PK------------LDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTT 1232
Query: 760 TEETSKPK 767
+++ KPK
Sbjct: 1233 PQKSRKPK 1240
Score = 45.8 bits (107), Expect = 1e-04
Identities = 164/846 (19%), Positives = 292/846 (34%), Gaps = 106/846 (12%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
M+ KPA P+ A ++T+ S K + P + G + + K + + SS
Sbjct: 627 MTAAQAKPALKI-PQTKACPKKTNTTASAKVA--PVRVGTQ--APRKAGTATSPAGSSPA 681
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
AGGT + S+SS + S +T T + KS L V +G +
Sbjct: 682 VAGGTQRPAEDSSSS----EESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 737
Query: 121 HTEP-------------KSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDM 167
T P K+ ++ S++ ++ +++A + A+ + S K T+ K P
Sbjct: 738 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA-- 795
Query: 168 ISAGGESVAGITAISGKPGDKKKEKKSLTPAV---PVESKPDK------PSGKSGMDAAL 218
+A S G + GK + K +P+ PV + + P+ + A+
Sbjct: 796 -AARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAV 854
Query: 219 DDLIDTLGGPEE----TEEENTTYTGPEVS---DPMSSTYI---------EELGKREVTI 262
GPEE +EEE+ + E P T+ E K
Sbjct: 855 ATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT 914
Query: 263 PPKYRELLAKKEGITGPPADSSKPIGPD-DAIDALSSDFTCGSPT--AAGKKTEKEESTE 319
PP A + G SS+ D +A A++S P ++ +
Sbjct: 915 PPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAAT 974
Query: 320 VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEA---LSASLGTR-----QAEPELDLR 371
+AQ+A T R A + R ++ + + A L+ + T A P + +
Sbjct: 975 PAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPK 1034
Query: 372 -------SIKE---VDEAKAKEEKLEKCGEDDETIPSEYRLKPA-----TDKDGKPLLPE 416
S KE + + K +E + T+P+ + T+K KP LPE
Sbjct: 1035 ASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPE 1094
Query: 417 PEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAP------VSEAVCR 470
++ K S D+ + D S E+ + + + + P P V E
Sbjct: 1095 VQQATKAPESS---DDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAE 1151
Query: 471 TSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREK 530
+S + + P + L G + A +S K D P + + D ++
Sbjct: 1152 SSEDDVVA--PSQSLLSGYMTPGLTPA--NSQASKATPKLDSSPSVSSTLAAKDDPDGKQ 1207
Query: 531 LGEKEET---IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDA-LSEDFSG---P 583
+ ++ + P +E K K P + L + +++ G P
Sbjct: 1208 EAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWP 1267
Query: 584 QNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDA------LDKLSD 637
N + ++ K+ + E + TT+ + S+ K D K
Sbjct: 1268 LNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKK 1327
Query: 638 SLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTK 697
LG + P + K KA+ RDK D + + L G + +
Sbjct: 1328 KLGAGEGGEASVSPEKTSTTSKGKAK-RDKAS--GDVKEKKGKGSLGSQGAKDEPEEELQ 1384
Query: 698 KSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSA 757
K + + D +P + S + + K K KKA++ + K K
Sbjct: 1385 KGMGTVEGGDQSNP-KSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKK 1443
Query: 758 KTTEET 763
KT E+T
Sbjct: 1444 KTAEQT 1449
Score = 43.1 bits (100), Expect = 0.001
Identities = 93/447 (20%), Positives = 159/447 (35%), Gaps = 53/447 (11%)
Query: 353 EALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLE-KCGEDDETIPSEYRLKPATDKDGK 411
+A S+S T + E D+ V A+ K + K + P+ ++ T +
Sbjct: 195 QADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKG 254
Query: 412 PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPS-KPTEKTEESKAA-APAPVSEAVC 469
LP + KP ESE +E SE + + + K +EK + +AA APA +
Sbjct: 255 GALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPG-- 312
Query: 470 RTSMCSIQSAPPEPATLKGTVPDDA----VEALADSLGKKEADPEDGKPVMDKVKEKAKE 525
+ A P P G V E ++S ++ +D E+ P + +
Sbjct: 313 -------KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 365
Query: 526 EDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQN 585
++G R GK P +K Q ED + D
Sbjct: 366 GKTSQVGAASAPAKESPRKGAAPAPPGK-TGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424
Query: 586 ASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTS------QSDKDLDDALDKLSDSL 639
A + A A S ++P A APPR T Q K +D+ +S
Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGA-APAPPRKTGPAAAQVQVGKQEEDSRSSSEESD 483
Query: 640 GQRQP----DPDENKPMEDKVKEK-AKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKP 694
R+ + + KP+ + K A LG+ +PP G+ P P
Sbjct: 484 SDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPP---------GKVGPATP 534
Query: 695 PT---KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPK--- 748
K EDS+ +++ D+ G++ + + + + K +S +K P
Sbjct: 535 SAQVGKWEEDSESSSEESS--DSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA 592
Query: 749 -------NGGKAKDSAKTTEETSKPKD 768
K D+++++EE+S D
Sbjct: 593 GPVAVQVKAEKPMDNSESSEESSDSAD 619
>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
homolog 2 [Homo sapiens]
Length = 1210
Score = 62.4 bits (150), Expect = 2e-09
Identities = 122/566 (21%), Positives = 206/566 (36%), Gaps = 81/566 (14%)
Query: 28 SEKTSESP----SKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSS 83
SE+T E P + P + E A++ SS S + + +S+ S SS +S S
Sbjct: 437 SEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESS--SSDSEE 494
Query: 84 MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDT-GSNDAHNK 142
P ET A + EP + +L K SQ P E P++ ++ GS+D+
Sbjct: 495 NEPLETPAPEPEP-PTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATS 553
Query: 143 KAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVE 202
+ S S + P S P+ P+ G + P ++ ++ T
Sbjct: 554 QEHSESKDPPPKSSSKAPRAPPE-------APHPGKRSCQKSPAQQEPPQRQ-TVGTKQP 605
Query: 203 SKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSD---PMSSTYIEELGKRE 259
KP K S ++G +L + G + T+ P+V P ++ E +
Sbjct: 606 KKPVKASARAGSRTSLQGEREP-GLLPYGSRDQTSKDKPKVKTKGRPRAAASNEP----K 660
Query: 260 VTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSS-----------DFTCGSP-TA 307
+PP KK+ + PA S GP+ A D + + G P +
Sbjct: 661 PAVPPSSE----KKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSG 716
Query: 308 AGKKTEKEESTEVLKAQS--------------AGTVRSAAPPQEKKRKVEKDTMSDQALE 353
+G +T V++ S +R PPQ K+ D +S
Sbjct: 717 SGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLS---RI 773
Query: 354 ALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPA-TDKDGKP 412
G+RQ R ++ K+ EK D + ++ R A D D K
Sbjct: 774 PQPPGKGSRQ-------RKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKK 826
Query: 413 LLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTS 472
+ E E K + S S E S K KPS+P+ ++ + + P PVS + + +
Sbjct: 827 IRLEKEIKSQSSSSSSSHKESS--------KTKPSRPSSQSSKKEMLPPPPVSSSSQKPA 878
Query: 473 MCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLG 532
+++ + E T P A K + P +V+ K E G
Sbjct: 879 KPALKRSRREADTCGQDPPKSASST-------KSNHKDSSIPKQRRVEGKGSRSSSEHKG 931
Query: 533 EKEETIPPDYRLEEVKDKDGKPLLPK 558
+T P + + + + + KP P+
Sbjct: 932 SSGDTANP-FPVPSLPNGNSKPGKPQ 956
Score = 35.0 bits (79), Expect = 0.26
Identities = 46/202 (22%), Positives = 69/202 (34%), Gaps = 41/202 (20%)
Query: 584 QNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPP----------------RDTSQSDKD 627
Q SS+ +D +L+ + QTP + APP S+S D
Sbjct: 417 QGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSD 476
Query: 628 LDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNG 687
D + D S+S D +EN+P+E E PP DN
Sbjct: 477 SDSSSDSESES---SSSDSEENEPLETPAPEPE---------------PPTTNKWQLDNW 518
Query: 688 QDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAP 747
K +P + P S D + TSQ ++ K SSSKAP
Sbjct: 519 LTKVSQPAAPPEGPRSTEPPRRHPESKGSSD-------SATSQEHSESKDPPPKSSSKAP 571
Query: 748 KNGGKAKDSAKTTEETSKPKDD 769
+ +A K + + S + +
Sbjct: 572 RAPPEAPHPGKRSCQKSPAQQE 593
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.298 0.120 0.321
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,990,585
Number of Sequences: 37866
Number of extensions: 1937130
Number of successful extensions: 15012
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 162
Number of HSP's successfully gapped in prelim test: 1124
Number of HSP's that attempted gapping in prelim test: 9273
Number of HSP's gapped (non-prelim): 4895
length of query: 769
length of database: 18,247,518
effective HSP length: 110
effective length of query: 659
effective length of database: 14,082,258
effective search space: 9280208022
effective search space used: 9280208022
T: 11
A: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.