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Search of human proteins with 109637761
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109637761 calpastatin isoform g [Homo sapiens]
(772 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109637761 calpastatin isoform g [Homo sapiens] 1524 0.0
gi|109637753 calpastatin isoform a [Homo sapiens] 1513 0.0
gi|109637759 calpastatin isoform f [Homo sapiens] 1466 0.0
gi|109637763 calpastatin isoform h [Homo sapiens] 1457 0.0
gi|109637757 calpastatin isoform e [Homo sapiens] 1421 0.0
gi|109637765 calpastatin isoform i [Homo sapiens] 1356 0.0
gi|109637767 calpastatin isoform j [Homo sapiens] 1309 0.0
gi|27765085 calpastatin isoform b [Homo sapiens] 1300 0.0
gi|109637771 calpastatin isoform l [Homo sapiens] 1273 0.0
gi|109637769 calpastatin isoform k [Homo sapiens] 1264 0.0
gi|27765087 calpastatin isoform c [Homo sapiens] 781 0.0
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 93 8e-19
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens] 69 2e-11
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 67 6e-11
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 67 6e-11
gi|104526627 triadin [Homo sapiens] 67 6e-11
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 65 3e-10
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 65 3e-10
gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 65 3e-10
gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 65 3e-10
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 64 4e-10
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 64 7e-10
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 63 9e-10
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 63 9e-10
gi|150170670 piccolo isoform 2 [Homo sapiens] 62 3e-09
gi|150378539 piccolo isoform 1 [Homo sapiens] 62 3e-09
gi|109637791 transcription factor-like nuclear regulator [Homo s... 60 6e-09
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 60 1e-08
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 59 1e-08
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 59 1e-08
>gi|109637761 calpastatin isoform g [Homo sapiens]
Length = 772
Score = 1524 bits (3946), Expect = 0.0
Identities = 772/772 (100%), Positives = 772/772 (100%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK 120
YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK
Sbjct: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK 120
Query: 121 KSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 180
KSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG
Sbjct: 121 KSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 180
Query: 181 ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT 240
ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT
Sbjct: 181 ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT 240
Query: 241 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS 300
YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS
Sbjct: 241 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS 300
Query: 301 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA 360
SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA
Sbjct: 301 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA 360
Query: 361 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 420
SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP
Sbjct: 361 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 420
Query: 421 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 480
EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ
Sbjct: 421 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 480
Query: 481 SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET 540
SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET
Sbjct: 481 SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET 540
Query: 541 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA 600
IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA
Sbjct: 541 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA 600
Query: 601 AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK 660
AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK
Sbjct: 601 AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK 660
Query: 661 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 720
EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG
Sbjct: 661 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 720
Query: 721 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 772
DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 721 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 772
>gi|109637753 calpastatin isoform a [Homo sapiens]
Length = 791
Score = 1513 bits (3916), Expect = 0.0
Identities = 772/791 (97%), Positives = 772/791 (97%), Gaps = 19/791 (2%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK 120
YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK
Sbjct: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK 120
Query: 121 KSQSTK-------------------PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKST 161
KSQSTK PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKST
Sbjct: 121 KSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKST 180
Query: 162 EPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAAL 221
EPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAAL
Sbjct: 181 EPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAAL 240
Query: 222 DDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITG 281
DDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITG
Sbjct: 241 DDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITG 300
Query: 282 PPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEK 341
PPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEK
Sbjct: 301 PPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEK 360
Query: 342 KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPS 401
KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPS
Sbjct: 361 KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPS 420
Query: 402 EYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKA 461
EYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKA
Sbjct: 421 EYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKA 480
Query: 462 AAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK 521
AAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK
Sbjct: 481 AAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK 540
Query: 522 VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE 581
VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE
Sbjct: 541 VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE 600
Query: 582 DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDS 641
DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDS
Sbjct: 601 DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDS 660
Query: 642 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK 701
LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK
Sbjct: 661 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK 720
Query: 702 SEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAK 761
SEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAK
Sbjct: 721 SEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAK 780
Query: 762 TTEETSKPKDD 772
TTEETSKPKDD
Sbjct: 781 TTEETSKPKDD 791
>gi|109637759 calpastatin isoform f [Homo sapiens]
Length = 750
Score = 1466 bits (3794), Expect = 0.0
Identities = 750/772 (97%), Positives = 750/772 (97%), Gaps = 22/772 (2%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK 120
YAGGTASATKVSASSGATSKSSSMNPTETKA VKTEPEK
Sbjct: 61 YAGGTASATKVSASSGATSKSSSMNPTETKA----------------------VKTEPEK 98
Query: 121 KSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 180
KSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG
Sbjct: 99 KSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 158
Query: 181 ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT 240
ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT
Sbjct: 159 ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT 218
Query: 241 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS 300
YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS
Sbjct: 219 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS 278
Query: 301 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA 360
SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA
Sbjct: 279 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA 338
Query: 361 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 420
SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP
Sbjct: 339 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 398
Query: 421 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 480
EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ
Sbjct: 399 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 458
Query: 481 SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET 540
SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET
Sbjct: 459 SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET 518
Query: 541 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA 600
IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA
Sbjct: 519 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA 578
Query: 601 AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK 660
AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK
Sbjct: 579 AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK 638
Query: 661 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 720
EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG
Sbjct: 639 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 698
Query: 721 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 772
DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 699 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 750
>gi|109637763 calpastatin isoform h [Homo sapiens]
Length = 769
Score = 1457 bits (3771), Expect = 0.0
Identities = 742/772 (96%), Positives = 750/772 (97%), Gaps = 3/772 (0%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK 120
YAGGTASATKVSASSGATSKSSSMNPTETKA+ + + H+K K++ K
Sbjct: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEK---KSQEGK 117
Query: 121 KSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 180
+ T+PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG
Sbjct: 118 PKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 177
Query: 181 ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT 240
ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT
Sbjct: 178 ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT 237
Query: 241 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS 300
YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS
Sbjct: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS 297
Query: 301 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA 360
SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA
Sbjct: 298 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA 357
Query: 361 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 420
SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP
Sbjct: 358 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 417
Query: 421 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 480
EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ
Sbjct: 418 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 477
Query: 481 SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET 540
SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET
Sbjct: 478 SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET 537
Query: 541 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA 600
IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA
Sbjct: 538 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA 597
Query: 601 AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK 660
AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK
Sbjct: 598 AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK 657
Query: 661 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 720
EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG
Sbjct: 658 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 717
Query: 721 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 772
DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 718 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 769
>gi|109637757 calpastatin isoform e [Homo sapiens]
Length = 756
Score = 1421 bits (3679), Expect = 0.0
Identities = 729/772 (94%), Positives = 737/772 (95%), Gaps = 16/772 (2%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK 120
YAGGTASATKVSASSGATSKSSSMNPTETKA+ + + H+K K++ K
Sbjct: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEK---KSQEGK 117
Query: 121 KSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 180
+ T+PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG
Sbjct: 118 PKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 177
Query: 181 ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT 240
ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT
Sbjct: 178 ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT 237
Query: 241 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS 300
YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK PIGPDDAIDALS
Sbjct: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK-------------PIGPDDAIDALS 284
Query: 301 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA 360
SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA
Sbjct: 285 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA 344
Query: 361 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 420
SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP
Sbjct: 345 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 404
Query: 421 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 480
EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ
Sbjct: 405 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 464
Query: 481 SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET 540
SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET
Sbjct: 465 SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET 524
Query: 541 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA 600
IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA
Sbjct: 525 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA 584
Query: 601 AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK 660
AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK
Sbjct: 585 AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK 644
Query: 661 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 720
EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG
Sbjct: 645 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 704
Query: 721 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 772
DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 705 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 756
>gi|109637765 calpastatin isoform i [Homo sapiens]
Length = 708
Score = 1356 bits (3509), Expect = 0.0
Identities = 689/708 (97%), Positives = 689/708 (97%), Gaps = 19/708 (2%)
Query: 84 MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTK----------------- 126
MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTK
Sbjct: 1 MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60
Query: 127 --PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 184
PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 61 TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 120
Query: 185 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 244
SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 121 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180
Query: 245 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 304
EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT
Sbjct: 181 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240
Query: 305 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 364
CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 241 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300
Query: 365 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 424
RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 301 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360
Query: 425 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 484
KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 361 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420
Query: 485 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 544
EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 421 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480
Query: 545 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 604
YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 481 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 540
Query: 605 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 664
EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 541 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 600
Query: 665 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 724
AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 601 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660
Query: 725 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 772
CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 661 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708
Score = 224 bits (570), Expect = 3e-58
Identities = 195/664 (29%), Positives = 315/664 (47%), Gaps = 82/664 (12%)
Query: 16 RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASS 75
+ A +R + SEK++E +KP + + G S ++A S
Sbjct: 81 KKAVSRSAEQQPSEKSTEPKTKPQD-------------------MISAGGESVAGITAIS 121
Query: 76 GATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAV-----------KTEPEKKSQS 124
G + T A+PV + P P+ K A+ +TE E + +
Sbjct: 122 GKPGDKKKEKKSLTPAVPVESK---PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 178
Query: 125 TKPKSLPKQAS---DTGSNDA-----HNKKAVSRSAEQQPSEKSTEPKTKPQDMISA-GG 175
S P ++ + G + + + + P S++P P D I A
Sbjct: 179 GPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP-IGPDDAIDALSS 237
Query: 176 ESVAGITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDDLIDT 227
+ G +GK +K++ + ++ A P + K K + D AL+ L +
Sbjct: 238 DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSAS 297
Query: 228 LGGPEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR-ELLAKKEG--ITGPP 283
L G + E E + EV + + +E+ G+ + TIP +YR + K+G + P
Sbjct: 298 L-GTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 356
Query: 284 ADSSKPIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLKAQSAGTVR 333
+ KP + ID LS DF P+ +KTE+ ++ +E + S +++
Sbjct: 357 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 416
Query: 334 SAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCG 393
SA P + K T+ D A+EAL+ SLG ++A+PE D + + + + KAKEE EK G
Sbjct: 417 SAPP----EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLG 471
Query: 394 EDDETIPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKP 452
E +ETIP +YRL+ DKDGKPLLP E +E+ P SE L+D LSEDF + +
Sbjct: 472 EKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NAS 526
Query: 453 TEKTEESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEAD 511
+ K E++K A A +SE V +T + Q+ APP + DDA++ L+DSLG+++ D
Sbjct: 527 SLKFEDAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPD 584
Query: 512 PEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPP 569
P++ KP+ DKVKEKAK E R+KLGE+++TIPP+YR + KP+ P K+S++ P
Sbjct: 585 PDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKP 644
Query: 570 MSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDK 629
+ +DALS D + + AK + S+ P + +A + T ++ K
Sbjct: 645 ADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSK 704
Query: 630 DLDD 633
DD
Sbjct: 705 PKDD 708
Score = 81.3 bits (199), Expect = 3e-15
Identities = 90/364 (24%), Positives = 153/364 (42%), Gaps = 24/364 (6%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
+ +P +KP PR + + + E PSKP EK + A + S RT
Sbjct: 353 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 410
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPH--LPNKKKHKKQAVKTEP 118
SA A+ T ++ E A + ++ P P K K++A + +
Sbjct: 411 SMCSIQSAPPEPATLKGTVPDDAV---EALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 467
Query: 119 EKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESV 178
EK + K +++P D K + + +++Q S + +G ++
Sbjct: 468 EKLGE--KEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNA 525
Query: 179 AGITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETE 235
+ + K E S TPA ++ P + + +S +D ALD L D+LG +
Sbjct: 526 SSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDP 585
Query: 236 EENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKP 289
+EN +V + + + ++LG+R+ TIPP+YR LL ++ PP DS KP
Sbjct: 586 DENKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKP 644
Query: 290 IGPDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRK 344
D IDALS D +C S T + T K++ + + A G + +A E+ K
Sbjct: 645 ADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSK 704
Query: 345 VEKD 348
+ D
Sbjct: 705 PKDD 708
>gi|109637767 calpastatin isoform j [Homo sapiens]
Length = 667
Score = 1309 bits (3387), Expect = 0.0
Identities = 667/689 (96%), Positives = 667/689 (96%), Gaps = 22/689 (3%)
Query: 84 MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAH 143
MNPTETKA VKTEPEKKSQSTKPKSLPKQASDTGSNDAH
Sbjct: 1 MNPTETKA----------------------VKTEPEKKSQSTKPKSLPKQASDTGSNDAH 38
Query: 144 NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 203
NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP
Sbjct: 39 NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 98
Query: 204 VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 263
VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV
Sbjct: 99 VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 158
Query: 264 TIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 323
TIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV
Sbjct: 159 TIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 218
Query: 324 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 383
LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK
Sbjct: 219 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 278
Query: 384 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 443
AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS
Sbjct: 279 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 338
Query: 444 ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD 503
ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD
Sbjct: 339 ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD 398
Query: 504 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES 563
SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES
Sbjct: 399 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES 458
Query: 564 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 623
KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD
Sbjct: 459 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 518
Query: 624 TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR 683
TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR
Sbjct: 519 TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR 578
Query: 684 HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA 743
HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA
Sbjct: 579 HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA 638
Query: 744 ASSSKAPKNGGKAKDSAKTTEETSKPKDD 772
ASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 639 ASSSKAPKNGGKAKDSAKTTEETSKPKDD 667
Score = 224 bits (570), Expect = 3e-58
Identities = 195/664 (29%), Positives = 315/664 (47%), Gaps = 82/664 (12%)
Query: 16 RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASS 75
+ A +R + SEK++E +KP + + G S ++A S
Sbjct: 40 KKAVSRSAEQQPSEKSTEPKTKPQD-------------------MISAGGESVAGITAIS 80
Query: 76 GATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAV-----------KTEPEKKSQS 124
G + T A+PV + P P+ K A+ +TE E + +
Sbjct: 81 GKPGDKKKEKKSLTPAVPVESK---PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 137
Query: 125 TKPKSLPKQAS---DTGSNDA-----HNKKAVSRSAEQQPSEKSTEPKTKPQDMISA-GG 175
S P ++ + G + + + + P S++P P D I A
Sbjct: 138 GPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP-IGPDDAIDALSS 196
Query: 176 ESVAGITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDDLIDT 227
+ G +GK +K++ + ++ A P + K K + D AL+ L +
Sbjct: 197 DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSAS 256
Query: 228 LGGPEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR-ELLAKKEG--ITGPP 283
L G + E E + EV + + +E+ G+ + TIP +YR + K+G + P
Sbjct: 257 L-GTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 315
Query: 284 ADSSKPIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLKAQSAGTVR 333
+ KP + ID LS DF P+ +KTE+ ++ +E + S +++
Sbjct: 316 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 375
Query: 334 SAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCG 393
SA P + K T+ D A+EAL+ SLG ++A+PE D + + + + KAKEE EK G
Sbjct: 376 SAPP----EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLG 430
Query: 394 EDDETIPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKP 452
E +ETIP +YRL+ DKDGKPLLP E +E+ P SE L+D LSEDF + +
Sbjct: 431 EKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NAS 485
Query: 453 TEKTEESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEAD 511
+ K E++K A A +SE V +T + Q+ APP + DDA++ L+DSLG+++ D
Sbjct: 486 SLKFEDAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPD 543
Query: 512 PEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPP 569
P++ KP+ DKVKEKAK E R+KLGE+++TIPP+YR + KP+ P K+S++ P
Sbjct: 544 PDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKP 603
Query: 570 MSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDK 629
+ +DALS D + + AK + S+ P + +A + T ++ K
Sbjct: 604 ADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSK 663
Query: 630 DLDD 633
DD
Sbjct: 664 PKDD 667
Score = 81.3 bits (199), Expect = 3e-15
Identities = 90/364 (24%), Positives = 153/364 (42%), Gaps = 24/364 (6%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
+ +P +KP PR + + + E PSKP EK + A + S RT
Sbjct: 312 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 369
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPH--LPNKKKHKKQAVKTEP 118
SA A+ T ++ E A + ++ P P K K++A + +
Sbjct: 370 SMCSIQSAPPEPATLKGTVPDDAV---EALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 426
Query: 119 EKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESV 178
EK + K +++P D K + + +++Q S + +G ++
Sbjct: 427 EKLGE--KEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNA 484
Query: 179 AGITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETE 235
+ + K E S TPA ++ P + + +S +D ALD L D+LG +
Sbjct: 485 SSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDP 544
Query: 236 EENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKP 289
+EN +V + + + ++LG+R+ TIPP+YR LL ++ PP DS KP
Sbjct: 545 DENKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKP 603
Query: 290 IGPDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRK 344
D IDALS D +C S T + T K++ + + A G + +A E+ K
Sbjct: 604 ADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSK 663
Query: 345 VEKD 348
+ D
Sbjct: 664 PKDD 667
>gi|27765085 calpastatin isoform b [Homo sapiens]
Length = 686
Score = 1300 bits (3364), Expect = 0.0
Identities = 659/689 (95%), Positives = 667/689 (96%), Gaps = 3/689 (0%)
Query: 84 MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAH 143
MNPTETKA+ + + H+K K++ K + T+PKSLPKQASDTGSNDAH
Sbjct: 1 MNPTETKAVKTEPEKKSQSTKLSVVHEK---KSQEGKPKEHTEPKSLPKQASDTGSNDAH 57
Query: 144 NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 203
NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP
Sbjct: 58 NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 117
Query: 204 VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 263
VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV
Sbjct: 118 VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 177
Query: 264 TIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 323
TIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV
Sbjct: 178 TIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 237
Query: 324 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 383
LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK
Sbjct: 238 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 297
Query: 384 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 443
AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS
Sbjct: 298 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 357
Query: 444 ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD 503
ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD
Sbjct: 358 ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD 417
Query: 504 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES 563
SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES
Sbjct: 418 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES 477
Query: 564 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 623
KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD
Sbjct: 478 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 537
Query: 624 TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR 683
TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR
Sbjct: 538 TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR 597
Query: 684 HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA 743
HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA
Sbjct: 598 HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA 657
Query: 744 ASSSKAPKNGGKAKDSAKTTEETSKPKDD 772
ASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 658 ASSSKAPKNGGKAKDSAKTTEETSKPKDD 686
Score = 224 bits (570), Expect = 3e-58
Identities = 195/664 (29%), Positives = 315/664 (47%), Gaps = 82/664 (12%)
Query: 16 RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASS 75
+ A +R + SEK++E +KP + + G S ++A S
Sbjct: 59 KKAVSRSAEQQPSEKSTEPKTKPQD-------------------MISAGGESVAGITAIS 99
Query: 76 GATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAV-----------KTEPEKKSQS 124
G + T A+PV + P P+ K A+ +TE E + +
Sbjct: 100 GKPGDKKKEKKSLTPAVPVESK---PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 156
Query: 125 TKPKSLPKQAS---DTGSNDA-----HNKKAVSRSAEQQPSEKSTEPKTKPQDMISA-GG 175
S P ++ + G + + + + P S++P P D I A
Sbjct: 157 GPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP-IGPDDAIDALSS 215
Query: 176 ESVAGITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDDLIDT 227
+ G +GK +K++ + ++ A P + K K + D AL+ L +
Sbjct: 216 DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSAS 275
Query: 228 LGGPEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR-ELLAKKEG--ITGPP 283
L G + E E + EV + + +E+ G+ + TIP +YR + K+G + P
Sbjct: 276 L-GTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 334
Query: 284 ADSSKPIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLKAQSAGTVR 333
+ KP + ID LS DF P+ +KTE+ ++ +E + S +++
Sbjct: 335 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 394
Query: 334 SAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCG 393
SA P + K T+ D A+EAL+ SLG ++A+PE D + + + + KAKEE EK G
Sbjct: 395 SAPP----EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLG 449
Query: 394 EDDETIPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKP 452
E +ETIP +YRL+ DKDGKPLLP E +E+ P SE L+D LSEDF + +
Sbjct: 450 EKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NAS 504
Query: 453 TEKTEESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEAD 511
+ K E++K A A +SE V +T + Q+ APP + DDA++ L+DSLG+++ D
Sbjct: 505 SLKFEDAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPD 562
Query: 512 PEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPP 569
P++ KP+ DKVKEKAK E R+KLGE+++TIPP+YR + KP+ P K+S++ P
Sbjct: 563 PDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKP 622
Query: 570 MSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDK 629
+ +DALS D + + AK + S+ P + +A + T ++ K
Sbjct: 623 ADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSK 682
Query: 630 DLDD 633
DD
Sbjct: 683 PKDD 686
Score = 81.3 bits (199), Expect = 3e-15
Identities = 90/364 (24%), Positives = 153/364 (42%), Gaps = 24/364 (6%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
+ +P +KP PR + + + E PSKP EK + A + S RT
Sbjct: 331 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 388
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPH--LPNKKKHKKQAVKTEP 118
SA A+ T ++ E A + ++ P P K K++A + +
Sbjct: 389 SMCSIQSAPPEPATLKGTVPDDAV---EALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 445
Query: 119 EKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESV 178
EK + K +++P D K + + +++Q S + +G ++
Sbjct: 446 EKLGE--KEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNA 503
Query: 179 AGITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETE 235
+ + K E S TPA ++ P + + +S +D ALD L D+LG +
Sbjct: 504 SSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDP 563
Query: 236 EENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKP 289
+EN +V + + + ++LG+R+ TIPP+YR LL ++ PP DS KP
Sbjct: 564 DENKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKP 622
Query: 290 IGPDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRK 344
D IDALS D +C S T + T K++ + + A G + +A E+ K
Sbjct: 623 ADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSK 682
Query: 345 VEKD 348
+ D
Sbjct: 683 PKDD 686
>gi|109637771 calpastatin isoform l [Homo sapiens]
Length = 654
Score = 1273 bits (3295), Expect = 0.0
Identities = 654/689 (94%), Positives = 654/689 (94%), Gaps = 35/689 (5%)
Query: 84 MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAH 143
MNPTETKA VKTEPEKKSQSTKPKSLPKQASDTGSNDAH
Sbjct: 1 MNPTETKA----------------------VKTEPEKKSQSTKPKSLPKQASDTGSNDAH 38
Query: 144 NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 203
NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP
Sbjct: 39 NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 98
Query: 204 VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 263
VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV
Sbjct: 99 VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 158
Query: 264 TIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 323
TIPPKYRELLAK PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV
Sbjct: 159 TIPPKYRELLAK-------------PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 205
Query: 324 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 383
LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK
Sbjct: 206 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 265
Query: 384 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 443
AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS
Sbjct: 266 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 325
Query: 444 ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD 503
ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD
Sbjct: 326 ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD 385
Query: 504 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES 563
SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES
Sbjct: 386 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES 445
Query: 564 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 623
KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD
Sbjct: 446 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 505
Query: 624 TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR 683
TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR
Sbjct: 506 TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR 565
Query: 684 HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA 743
HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA
Sbjct: 566 HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA 625
Query: 744 ASSSKAPKNGGKAKDSAKTTEETSKPKDD 772
ASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 626 ASSSKAPKNGGKAKDSAKTTEETSKPKDD 654
Score = 223 bits (569), Expect = 4e-58
Identities = 193/652 (29%), Positives = 310/652 (47%), Gaps = 71/652 (10%)
Query: 16 RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASS 75
+ A +R + SEK++E +KP + + G S ++A S
Sbjct: 40 KKAVSRSAEQQPSEKSTEPKTKPQD-------------------MISAGGESVAGITAIS 80
Query: 76 GATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKT------EPEKKSQSTKPKS 129
G + T A+PV + P P+ K A+ PE+ + +
Sbjct: 81 GKPGDKKKEKKSLTPAVPVESK---PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 137
Query: 130 LPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK-TKPQDMISA-GGESVAGITAISGK 187
P+ + S + ++ R P + K P D I A + G +GK
Sbjct: 138 GPEVSDPMSS--TYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGK 195
Query: 188 PGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENT 239
+K++ + ++ A P + K K + D AL+ L +L G + E E
Sbjct: 196 KTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL-GTRQAEPELD 254
Query: 240 TYTGPEVSDPMS-STYIEELGKREVTIPPKYR-ELLAKKEG--ITGPPADSSKPIGPDDA 295
+ EV + + +E+ G+ + TIP +YR + K+G + P + KP +
Sbjct: 255 LRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESEL 314
Query: 296 IDALSSDFTCG----SPTAAGKKTEKEES------TEVLKAQSAGTVRSAAPPQEKKRKV 345
ID LS DF P+ +KTE+ ++ +E + S +++SA P +
Sbjct: 315 IDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP----EPAT 370
Query: 346 EKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 405
K T+ D A+EAL+ SLG ++A+PE D + + + + KAKEE EK GE +ETIP +YRL
Sbjct: 371 LKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRL 429
Query: 406 KPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAP 464
+ DKDGKPLLP E +E+ P SE L+D LSEDF + + + K E++K A
Sbjct: 430 EEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA-- 482
Query: 465 APVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVK 523
A +SE V +T + Q+ APP + DDA++ L+DSLG+++ DP++ KP+ DKVK
Sbjct: 483 AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK 542
Query: 524 EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSE 581
EKAK E R+KLGE+++TIPP+YR + KP+ P K+S++ P + +DALS
Sbjct: 543 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 602
Query: 582 DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 633
D + + AK + S+ P + +A + T ++ K DD
Sbjct: 603 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 654
Score = 81.3 bits (199), Expect = 3e-15
Identities = 90/364 (24%), Positives = 153/364 (42%), Gaps = 24/364 (6%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
+ +P +KP PR + + + E PSKP EK + A + S RT
Sbjct: 299 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 356
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPH--LPNKKKHKKQAVKTEP 118
SA A+ T ++ E A + ++ P P K K++A + +
Sbjct: 357 SMCSIQSAPPEPATLKGTVPDDAV---EALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 413
Query: 119 EKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESV 178
EK + K +++P D K + + +++Q S + +G ++
Sbjct: 414 EKLGE--KEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNA 471
Query: 179 AGITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETE 235
+ + K E S TPA ++ P + + +S +D ALD L D+LG +
Sbjct: 472 SSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDP 531
Query: 236 EENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKP 289
+EN +V + + + ++LG+R+ TIPP+YR LL ++ PP DS KP
Sbjct: 532 DENKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKP 590
Query: 290 IGPDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRK 344
D IDALS D +C S T + T K++ + + A G + +A E+ K
Sbjct: 591 ADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSK 650
Query: 345 VEKD 348
+ D
Sbjct: 651 PKDD 654
>gi|109637769 calpastatin isoform k [Homo sapiens]
Length = 673
Score = 1264 bits (3272), Expect = 0.0
Identities = 646/689 (93%), Positives = 654/689 (94%), Gaps = 16/689 (2%)
Query: 84 MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAH 143
MNPTETKA+ + + H+K K++ K + T+PKSLPKQASDTGSNDAH
Sbjct: 1 MNPTETKAVKTEPEKKSQSTKLSVVHEK---KSQEGKPKEHTEPKSLPKQASDTGSNDAH 57
Query: 144 NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 203
NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP
Sbjct: 58 NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 117
Query: 204 VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 263
VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV
Sbjct: 118 VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 177
Query: 264 TIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 323
TIPPKYRELLAK PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV
Sbjct: 178 TIPPKYRELLAK-------------PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 224
Query: 324 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 383
LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK
Sbjct: 225 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 284
Query: 384 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 443
AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS
Sbjct: 285 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 344
Query: 444 ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD 503
ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD
Sbjct: 345 ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD 404
Query: 504 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES 563
SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES
Sbjct: 405 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES 464
Query: 564 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 623
KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD
Sbjct: 465 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 524
Query: 624 TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR 683
TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR
Sbjct: 525 TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR 584
Query: 684 HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA 743
HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA
Sbjct: 585 HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA 644
Query: 744 ASSSKAPKNGGKAKDSAKTTEETSKPKDD 772
ASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 645 ASSSKAPKNGGKAKDSAKTTEETSKPKDD 673
Score = 223 bits (569), Expect = 4e-58
Identities = 193/652 (29%), Positives = 310/652 (47%), Gaps = 71/652 (10%)
Query: 16 RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASS 75
+ A +R + SEK++E +KP + + G S ++A S
Sbjct: 59 KKAVSRSAEQQPSEKSTEPKTKPQD-------------------MISAGGESVAGITAIS 99
Query: 76 GATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKT------EPEKKSQSTKPKS 129
G + T A+PV + P P+ K A+ PE+ + +
Sbjct: 100 GKPGDKKKEKKSLTPAVPVESK---PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 156
Query: 130 LPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK-TKPQDMISA-GGESVAGITAISGK 187
P+ + S + ++ R P + K P D I A + G +GK
Sbjct: 157 GPEVSDPMSS--TYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGK 214
Query: 188 PGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENT 239
+K++ + ++ A P + K K + D AL+ L +L G + E E
Sbjct: 215 KTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL-GTRQAEPELD 273
Query: 240 TYTGPEVSDPMS-STYIEELGKREVTIPPKYR-ELLAKKEG--ITGPPADSSKPIGPDDA 295
+ EV + + +E+ G+ + TIP +YR + K+G + P + KP +
Sbjct: 274 LRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESEL 333
Query: 296 IDALSSDFTCG----SPTAAGKKTEKEES------TEVLKAQSAGTVRSAAPPQEKKRKV 345
ID LS DF P+ +KTE+ ++ +E + S +++SA P +
Sbjct: 334 IDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP----EPAT 389
Query: 346 EKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 405
K T+ D A+EAL+ SLG ++A+PE D + + + + KAKEE EK GE +ETIP +YRL
Sbjct: 390 LKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRL 448
Query: 406 KPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAP 464
+ DKDGKPLLP E +E+ P SE L+D LSEDF + + + K E++K A
Sbjct: 449 EEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA-- 501
Query: 465 APVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVK 523
A +SE V +T + Q+ APP + DDA++ L+DSLG+++ DP++ KP+ DKVK
Sbjct: 502 AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK 561
Query: 524 EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSE 581
EKAK E R+KLGE+++TIPP+YR + KP+ P K+S++ P + +DALS
Sbjct: 562 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 621
Query: 582 DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 633
D + + AK + S+ P + +A + T ++ K DD
Sbjct: 622 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 673
Score = 81.3 bits (199), Expect = 3e-15
Identities = 90/364 (24%), Positives = 153/364 (42%), Gaps = 24/364 (6%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
+ +P +KP PR + + + E PSKP EK + A + S RT
Sbjct: 318 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 375
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPH--LPNKKKHKKQAVKTEP 118
SA A+ T ++ E A + ++ P P K K++A + +
Sbjct: 376 SMCSIQSAPPEPATLKGTVPDDAV---EALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 432
Query: 119 EKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESV 178
EK + K +++P D K + + +++Q S + +G ++
Sbjct: 433 EKLGE--KEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNA 490
Query: 179 AGITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETE 235
+ + K E S TPA ++ P + + +S +D ALD L D+LG +
Sbjct: 491 SSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDP 550
Query: 236 EENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKP 289
+EN +V + + + ++LG+R+ TIPP+YR LL ++ PP DS KP
Sbjct: 551 DENKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKP 609
Query: 290 IGPDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRK 344
D IDALS D +C S T + T K++ + + A G + +A E+ K
Sbjct: 610 ADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSK 669
Query: 345 VEKD 348
+ D
Sbjct: 670 PKDD 673
>gi|27765087 calpastatin isoform c [Homo sapiens]
Length = 430
Score = 781 bits (2017), Expect = 0.0
Identities = 391/393 (99%), Positives = 392/393 (99%), Gaps = 1/393 (0%)
Query: 380 DEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 439
D+AKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED
Sbjct: 39 DQAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 98
Query: 440 FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 499
FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE
Sbjct: 99 FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 158
Query: 500 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 559
ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL
Sbjct: 159 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 218
Query: 560 PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA 619
PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA
Sbjct: 219 PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA 278
Query: 620 PPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP 679
PPRDTS SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP
Sbjct: 279 PPRDTS-SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP 337
Query: 680 PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK 739
PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK
Sbjct: 338 PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK 397
Query: 740 CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 772
CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 398 CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 430
Score = 206 bits (525), Expect = 5e-53
Identities = 144/396 (36%), Positives = 213/396 (53%), Gaps = 30/396 (7%)
Query: 255 IEELGKREVTIPPKYR-ELLAKKEG--ITGPPADSSKPIGPDDAIDALSSDFTCGSPTAA 311
+E+ G+ + TIP +YR + K+G + P + KP + ID LS DF
Sbjct: 48 LEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSE--CK 105
Query: 312 GKKTEKEESTEVLKAQSAGTVRSA-----------APPQEKKRKVEKDTMSDQALEALSA 360
K ++ E TE KA + V A APP+ K T+ D A+EAL+
Sbjct: 106 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLK---GTVPDDAVEALAD 162
Query: 361 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP-E 419
SLG ++A+PE D + + + + KAKEE EK GE +ETIP +YRL+ DKDGKPLLP E
Sbjct: 163 SLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE 221
Query: 420 PEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSI 479
+E+ P SE L+D LSEDF + + + K E++K A A +SE V +T +
Sbjct: 222 SKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA--AAISEVVSQTPASTT 274
Query: 480 QSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEE 539
Q+ P T DDA++ L+DSLG+++ DP++ KP+ DKVKEKAK E R+KLGE+++
Sbjct: 275 QAGAPPRDTSSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDD 334
Query: 540 TIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDA 597
TIPP+YR + KP+ P K+S++ P + +DALS D + + A
Sbjct: 335 TIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTA 394
Query: 598 KLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 633
K + S+ P + +A + T ++ K DD
Sbjct: 395 KDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 430
Score = 83.2 bits (204), Expect = 8e-16
Identities = 90/363 (24%), Positives = 150/363 (41%), Gaps = 23/363 (6%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
+ +P +KP PR + + + E PSKP EK + A + S RT
Sbjct: 76 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 133
Query: 61 YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPH--LPNKKKHKKQAVKTEP 118
SA A+ T ++ E A + ++ P P K K++A + +
Sbjct: 134 SMCSIQSAPPEPATLKGTVPDDAV---EALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 190
Query: 119 EKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESV 178
EK + K +++P D K + + +++Q S + +G ++
Sbjct: 191 EKLGE--KEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNA 248
Query: 179 AGITAISGKPGDKKKEKKSLTPAVPVES--KPDKPSGKSGMDAALDDLIDTLGGPEETEE 236
+ + K E S TPA ++ P S +D ALD L D+LG + +
Sbjct: 249 SSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSSDKDLDDALDKLSDSLGQRQPDPD 308
Query: 237 ENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPI 290
EN +V + + + ++LG+R+ TIPP+YR LL ++ PP DS KP
Sbjct: 309 ENKPMED-KVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPA 367
Query: 291 GPDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKV 345
D IDALS D +C S T + T K++ + + A G + +A E+ K
Sbjct: 368 DDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKP 427
Query: 346 EKD 348
+ D
Sbjct: 428 KDD 430
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 93.2 bits (230), Expect = 8e-19
Identities = 123/569 (21%), Positives = 218/569 (38%), Gaps = 68/569 (11%)
Query: 23 THEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSS 82
T E E+ E+ + G+++ E++ A G ++ A AS K + S K
Sbjct: 467 TEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSP---VKEE 523
Query: 83 SMNPTETKAIPVSQQMEGP---HLPNKKKHK-KQAVKTEPEKKSQSTKPKSLPKQASDTG 138
+ +P E K+ P ++ + P P K K K+ K+ PE KS + P +
Sbjct: 524 AKSPAEAKS-PEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPE 582
Query: 139 SNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSL 198
+ K+ AE + EK+ P ++ + E+ + + + P + K +K+
Sbjct: 583 KAKSPAKEEAKSPAEAKSPEKAKSPV---KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAK 639
Query: 199 TPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEEL 258
+P P+K +A PE+ + P ++ S +
Sbjct: 640 SPTKEEAKSPEKAKSPEKEEAK---------SPEKAKS-------PVKAEAKSPEKAKSP 683
Query: 259 GKREVTIPPK----YRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKK 314
K E P K +E E P + +K P+ A + + + K
Sbjct: 684 VKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK--SPEKAKSPVKEEAKTPEKAKSPVK 741
Query: 315 TEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLR 374
E + + + A T+ +P + K E + +D+ E + + PE
Sbjct: 742 EEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKS 801
Query: 375 SIKEVDEAKAKEEKLEKCGE-----DDETIPSEYRLKPATDK---DGKPLLPEPEEKPKP 426
+KE +AKA E+++ K E +E P E ++K K + P P+ EEK
Sbjct: 802 PLKE--DAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDS 859
Query: 427 RSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEP 486
+ E + ++ + + +EK EK +ESK A E
Sbjct: 860 KKE----EAPKKEAPKPKVEEKKEPAVEKPKESKV-------------------EAKKEE 896
Query: 487 ATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIP--PD 544
A K VP EA A K++A P++ V K + AK ++ K EK+E P D
Sbjct: 897 AEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKD 956
Query: 545 YRLEEVKDKDGKPLLPKESKEQLPPMSED 573
+ E+ K + KP ++KE +S++
Sbjct: 957 TKEEKAKKPEEKPKTEAKAKEDDKTLSKE 985
Score = 91.3 bits (225), Expect = 3e-18
Identities = 138/596 (23%), Positives = 225/596 (37%), Gaps = 57/596 (9%)
Query: 200 PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELG 259
P +P S K + + +T+ E+TEE T EV++ EE G
Sbjct: 427 PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVT---EEVTEEEEKEAKEEEG 483
Query: 260 KREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEE 319
K E + E +E PPA+ + P+ +A S A K EKEE
Sbjct: 484 KEEEG--GEEEEAEGGEEETKSPPAEEAA--SPEK--EAKSPVKEEAKSPAEAKSPEKEE 537
Query: 320 STEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEV 379
+ + +S +S A + K K ++A + P + K
Sbjct: 538 AKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKE--EAKSP 595
Query: 380 DEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 439
EAK+ E+ E+ ++ P+E + + + PE+ P E E ++
Sbjct: 596 AEAKSPEKAKSPVKEEAKS-PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKS 654
Query: 440 FDRSECK--EKPSKPTEKTEESKAAAPAPV-SEAVCRTSMCS-IQSAPPEPATLKGTVPD 495
++ E K EK P + +S A +PV +EA S ++ P K V +
Sbjct: 655 PEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKE 714
Query: 496 DAVEA-LADSLGKKEAD-PEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDK 553
+A A S K+EA PE K VKE+AK ++ K EK +T+ +VK
Sbjct: 715 EAKSPEKAKSPVKEEAKTPEKAK---SPVKEEAKSPEKAKSPEKAKTL-------DVKSP 764
Query: 554 DGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAA--------AISE 605
+ K +E++ E + E+ P+ A S EDAK S
Sbjct: 765 EAKTPAKEEARSPADKFPEK-AKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSP 823
Query: 606 VVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA-- 663
V + + PP+ + ++ DS + P + KP ++ KE A
Sbjct: 824 VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883
Query: 664 -----KAEHRDKLGERDDTIP-PEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD--DQDPI 715
K E + + E +P PE ++ P K K+ K+ + ++P
Sbjct: 884 KPKESKVEAKKEEAEDKKKVPTPE---------KEAPAKVEVKEDAKPKEKTEVAKKEPD 934
Query: 716 DALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKT-TEETSKPK 770
DA + + E + K +KA + PK KAK+ KT ++E SKPK
Sbjct: 935 DAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPK 990
Score = 85.1 bits (209), Expect = 2e-16
Identities = 122/528 (23%), Positives = 208/528 (39%), Gaps = 67/528 (12%)
Query: 269 YRELLAKKEGITG-PPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQ 327
YR+LL +E G P S P G I ++S+ S + E+ T +++ Q
Sbjct: 402 YRKLLEGEECRIGFGPIPFSLPEGLPK-IPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQ 460
Query: 328 SAGT-VRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQ---------AEPELDLRS-I 376
+ T V +E+K E++ ++ E A G + A PE + +S +
Sbjct: 461 TEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPV 520
Query: 377 KEVDE--AKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELID 434
KE + A+AK + E+ E E PA ++ P + EK + +S +E+
Sbjct: 521 KEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEV-- 578
Query: 435 ELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVP 494
S + +S KE+ P E KA +P ++ PA K V
Sbjct: 579 -KSPEKAKSPAKEEAKSPAEAKSPEKAKSP--------------VKEEAKSPAEAKSPVK 623
Query: 495 DDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKD 554
++A K A+ + + KE+AK ++ K EKEE P+ VK +
Sbjct: 624 EEA---------KSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674
Query: 555 GKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAST 614
P K S + S + + E+ P+ A S E+AK V + +
Sbjct: 675 KSPEKAK-SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP 733
Query: 615 TQAGAPPRDTSQSD---------KDLDDALDKLSDSLGQRQPDPDENKPMEDK--VKEKA 663
+A +P ++ ++S K LD + + P + P + K VKE+
Sbjct: 734 EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEV 793
Query: 664 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 723
K+ + K ++D PE + + + VK P K+ E ++ + P A + +
Sbjct: 794 KSPEKAKSPLKEDAKAPE-----KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKA---EEE 845
Query: 724 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKD 771
P+T +T + KD K+ A +AP K K K KPK+
Sbjct: 846 KAPATPKTEEK--KDSKKEEAPKKEAP----KPKVEEKKEPAVEKPKE 887
Score = 81.6 bits (200), Expect = 2e-15
Identities = 146/641 (22%), Positives = 238/641 (37%), Gaps = 72/641 (11%)
Query: 92 IPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRS 151
IP S P +P+ H +K + E+K + + + + + + V+
Sbjct: 418 IPFSLPEGLPKIPSVSTH----IKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEE 473
Query: 152 AEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAV--PVESK-P 208
E++ E+ + + ++ + GGE +K+ K + P E+K P
Sbjct: 474 EEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSP 533
Query: 209 DKPSGKSGMDAALDDLI------DTLGGPEETEEENTTYTGP-EVSDP--MSSTYIEELG 259
+K KS + + + PE E P EV P S EE
Sbjct: 534 EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 593
Query: 260 KREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDA-LSSDFTCGSPTAA-GKKTEK 317
P+ + K+E + PA++ P+ + A + S SPT K EK
Sbjct: 594 SPAEAKSPEKAKSPVKEEAKS--PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEK 651
Query: 318 EESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA--EPELDLRS 375
+S E +A+S +S + K + K + +A A ++ PE
Sbjct: 652 AKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP 711
Query: 376 IKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDE 435
+KE EAK+ E+ E+ +T E P ++ P EK K +++ +D
Sbjct: 712 VKE--EAKSPEKAKSPVKEEAKT--PEKAKSPVKEEAKSP------EKAKSPEKAKTLDV 761
Query: 436 LSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPD 495
S + ++ KE+ P +K E A +PV E V P K + +
Sbjct: 762 KSPEA-KTPAKEEARSPADKFPEK---AKSPVKEEV------------KSPEKAKSPLKE 805
Query: 496 DAVEALADSLGKKEADP----EDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVK 551
DA +A + KKE E+ KP KVKE K+ + EK P + EE K
Sbjct: 806 DA-KAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA-------PATPKTEEKK 857
Query: 552 DKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTP 611
D K PK KE P E+ A+ + A + ED K E +
Sbjct: 858 DSK-KEEAPK--KEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPT-PEKEAPAK 913
Query: 612 ASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPM--------EDKVKEKA 663
+ P T + K+ DDA K +++ E K E+K K +A
Sbjct: 914 VEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEA 973
Query: 664 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSED 704
KA+ DK ++ + P + + K KPP K +ED
Sbjct: 974 KAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014
Score = 77.8 bits (190), Expect = 4e-14
Identities = 109/506 (21%), Positives = 196/506 (38%), Gaps = 54/506 (10%)
Query: 4 PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAG 63
P ++ A SP ++ K+ E P +++ +A S ++
Sbjct: 519 PVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEV 578
Query: 64 GTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGP---HLPNKKKHKKQAVKTEPEK 120
+ K A A S + + +P + K+ PV ++ + P P K++ K A PEK
Sbjct: 579 KSPEKAKSPAKEEAKSPAEAKSPEKAKS-PVKEEAKSPAEAKSPVKEEAKSPAEVKSPEK 637
Query: 121 KSQSTKPKSL-PKQASDTGSNDAHNK-------KAVSRSAEQQPSEKSTEPKTKPQDMIS 172
TK ++ P++A +A + KA ++S E+ S E K+ +
Sbjct: 638 AKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSP 697
Query: 173 AGGESVAGITAISGKPGDKKKEKKSLTPA-----VPVESK-PDKPSGKSGMDAALDDLID 226
E+ + A S + K +K+ +P P ++K P K KS A +
Sbjct: 698 VKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAK 757
Query: 227 TLG--GPEETE--EENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLA------KK 276
TL PE +E + + S EE+ E P + A KK
Sbjct: 758 TLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKK 817
Query: 277 EGITGPPADSSKP--IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRS 334
E + P + KP + + + +P KK K+E +A
Sbjct: 818 EEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK 877
Query: 335 AAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGE 394
P EK ++ + + ++A + ++A +++++ ++AK KE K E +
Sbjct: 878 KEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVK-----EDAKPKE-KTEVAKK 931
Query: 395 DDETIPSEYRLKPATDKDGKP--------LLPEPEEKPKPRSESELIDE-LSEDFDR--- 442
+ + ++ KPA K+ P +PEEKPK ++++ D+ LS++ +
Sbjct: 932 EPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKA 991
Query: 443 ------SECKEKPSKPTEKTEESKAA 462
S +K SKP EK E KAA
Sbjct: 992 EKAEKSSSTDQKDSKPPEKATEDKAA 1017
Score = 47.8 bits (112), Expect = 4e-05
Identities = 59/270 (21%), Positives = 103/270 (38%), Gaps = 46/270 (17%)
Query: 514 DGKPVMDKVKE--KAKEEDREKLGEK--------EETIPPDYRLEEVKDKDGKPLLPKES 563
+G P + V K K E++ K+ EK EE EEV +++ K +E
Sbjct: 424 EGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEG 483
Query: 564 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 623
KE+ E E G + S E+A + +A +P ++
Sbjct: 484 KEEEGGEEE--------EAEGGEEETKSPPAEEAA-------------SPEKEAKSPVKE 522
Query: 624 TSQSDKDLDDALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEY 682
++S + + P+ +E K P E K EKAK+ +++ + PE
Sbjct: 523 EAKSPAEA-------------KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK 569
Query: 683 RHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKK 742
P K + E++K PA+ + P A S + S E +++ K++ K
Sbjct: 570 EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAE-AKSPVKEEAKS 628
Query: 743 AASSSKAPKNGGKAKDSAKTTEETSKPKDD 772
A K K+ AK+ E+ P+ +
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658
>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
Length = 1163
Score = 68.9 bits (167), Expect = 2e-11
Identities = 163/837 (19%), Positives = 293/837 (35%), Gaps = 117/837 (13%)
Query: 5 GQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAG- 63
G P+ S +R++ + H S++TS S G + + S SSR
Sbjct: 112 GPAPSTSQSQKRSSGLQSGHS--SQRTSAGSSSGTNSSGQRHDRESYNNSGSSSRKKGQH 169
Query: 64 GTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKK-- 121
G+ + S+S G SS+N + S+ H + K+H++ +P+
Sbjct: 170 GSEHSKSRSSSPGKPQAVSSLNSSH------SRSHGNDH--HSKEHQRSKSPRDPDANWD 221
Query: 122 SQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPS--------EKSTEPKTKPQDMISA 173
S S P S + ++ + +K S S Q+P+ ++S EPK + S
Sbjct: 222 SPSRVPFSSGQHSTQSFPPSLMSK---SNSMLQKPTAYVRPMDGQESMEPKLSSEHYSSQ 278
Query: 174 G-GESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDL-------I 225
G S+ + KP K K P+ P+++ S +D L ++ +
Sbjct: 279 SHGNSMTEL-----KPSSKAHLTKLKIPSQPLDASAS--GDVSCVDEILKEMTHSWPPPL 331
Query: 226 DTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPAD 285
+ P +TE + E T G+++ P K K + D
Sbjct: 332 TAIHTPCKTEPSKFPFPTKESQQSNFGT-----GEQKRYNPSKTSNGHQSKSMLK----D 382
Query: 286 SSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKV 345
K +D+ D T T ++E A ++ S+ E
Sbjct: 383 DLKLSSSEDSDGEQDCDKTMPRSTPGSNSEPSHHNSE--GADNSRDDSSSHSGSESSSGS 440
Query: 346 EKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDE--AKAKEEKLEKCGEDDETIPSEY 403
+ ++ S + + + EPE + ++D K K+ D IPS
Sbjct: 441 DSESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQ 500
Query: 404 RLKPA----------TDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPT 453
K TD G P+ P +S+ I + SE + S T
Sbjct: 501 GYKKEGREQGTGNSYTDTSG----PKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDST 556
Query: 454 EKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGK---KEA 510
+ P +A ++ P L ++P +A K K+
Sbjct: 557 TQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKE 616
Query: 511 DPEDGKPVMDKVKEKAKEEDREKLGE------------KEETIPPDYRLEEVKDKDGKPL 558
+P +K K K+ + +K E + E++PP + + + + P+
Sbjct: 617 SKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNRTPV 676
Query: 559 LPKESKEQ--------LPPMSEDFLLDALSEDFSGPQNASSL--KFEDAKLAAAISEVVS 608
P +E+ PM E LL LSE P + L K + L +
Sbjct: 677 KPSSVEEEDSFFRQRMFSPMEEKELLSPLSE----PDDRYPLIVKIDLNLLTRIPGKPYK 732
Query: 609 QT-PASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEH 667
+T P + P + T ++ K A +K+S+ ++ + D+N+ E K K K E
Sbjct: 733 ETEPPKGEKKNVPEKHTREAQKQ---ASEKVSNKGKRKHKNEDDNRASESK---KPKTED 786
Query: 668 RDKLGERDDT-------IPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 720
++ G + + + + LL P K P + K+ + + S
Sbjct: 787 KNSAGHKPSSNRESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSN 846
Query: 721 DLDSCPSTTETSQNTAKDKCKKAASSS-------KAPKNGGKAKDSAKTTEETSKPK 770
+++ S +T+K K + +SS KAP + SA T ++SKP+
Sbjct: 847 SNKETSGSSKNSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTL-DSSKPR 902
Score = 42.4 bits (98), Expect = 0.002
Identities = 103/503 (20%), Positives = 189/503 (37%), Gaps = 65/503 (12%)
Query: 2 SQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTY 61
++P Q +ASP P + ++ K + P K D +S G + R
Sbjct: 454 NEPSQ--SASPEPEPPPTNKWQLDNWLNKVN--PHKVSPASSVDSNIPSSQGYKKEGREQ 509
Query: 62 AGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKK 121
G + + +SG SS+ ++K I K + + P +
Sbjct: 510 GTGNS----YTDTSGPKETSSATPGRDSKTI------------QKGSESGRGRQKSPAQS 553
Query: 122 SQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESV-AG 180
+T+ +++ K+ KKA +AE+ E +T P D+ S+ S
Sbjct: 554 DSTTQRRTVGKKQP---------KKAEKAAAEEPRGGLKIESET-PVDLASSMPSSRHKA 603
Query: 181 ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENT- 239
T S KP KK+ K S P E K K + KS + ++I+T +++E +
Sbjct: 604 ATKGSRKPNIKKESKSSPRPTA--EKKKYKSTSKSSQKSR--EIIETDTSSSDSDESESL 659
Query: 240 -----TYTGPEVS-DPMSSTYIEE---LGKREVTIPPKYRELLAKKEGITGPPADSSKPI 290
T PE + P+ + +EE ++ + P + +ELL+ ++ P D P+
Sbjct: 660 PPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSP---LSEP--DDRYPL 714
Query: 291 GPDDAIDALS----SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE 346
++ L+ + P KK E+ T + Q++ V + ++K K E
Sbjct: 715 IVKIDLNLLTRIPGKPYKETEPPKGEKKNVPEKHTREAQKQASEKVSNKG---KRKHKNE 771
Query: 347 KDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLK 406
D + ++ + + + +P + S K+ AK K+ G +PS+
Sbjct: 772 DDNRASESKKPKTEDKNSAGHKPSSNRESSKQ-SAAKEKDLLPSPAGP----VPSK---D 823
Query: 407 PATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAP 466
P T+ + K S S S S K+K ++ + + AP
Sbjct: 824 PKTEHGSRKRTISQSSSLKSSSNSNKETSGSSKNSSSTSKQKKTEGKTSSSSKEVKEKAP 883
Query: 467 VSEAVCRTSMCSIQSAPPEPATL 489
S + C S ++ S+ P L
Sbjct: 884 SSSSNCPPSAPTLDSSKPRRTKL 906
Score = 39.3 bits (90), Expect = 0.014
Identities = 142/760 (18%), Positives = 244/760 (32%), Gaps = 119/760 (15%)
Query: 24 HEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSS 83
H + + +P P +K+++ L S SS+ + G++S T SSG S
Sbjct: 99 HGGSHQSSKWTPVGPAPSTSQSQKRSSGLQSGHSSQRTSAGSSSGTN---SSGQRHDRES 155
Query: 84 MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAH 143
N + G K +H + K+ + SL S + ND H
Sbjct: 156 YNNS------------GSSSRKKGQHGSEHSKSRSSSPGKPQAVSSLNSSHSRSHGNDHH 203
Query: 144 NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 203
+K+ + + P P P S+G S S P K L
Sbjct: 204 SKEHQRSKSPRDPDANWDSPSRVP---FSSGQHSTQ-----SFPPSLMSKSNSML----- 250
Query: 204 VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 263
KP+ + + G E E + ++ S S T ++ K +
Sbjct: 251 -----QKPTA----------YVRPMDGQESMEPKLSSEHYSSQSHGNSMTELKPSSKAHL 295
Query: 264 TIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSP---TAAGKKTEKEES 320
T K I P D+S G +D + + T P TA + E S
Sbjct: 296 T-----------KLKIPSQPLDASAS-GDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPS 343
Query: 321 -----TEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRS 375
T+ + + GT ++K+ K + Q+ L + +L L S
Sbjct: 344 KFPFPTKESQQSNFGT------GEQKRYNPSKTSNGHQSKSML---------KDDLKLSS 388
Query: 376 IKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDE 435
++ D + + D+T+P R P ++ + E + + S S E
Sbjct: 389 SEDSDGEQ----------DCDKTMP---RSTPGSNSEPSHHNSEGADNSRDDSSSHSGSE 435
Query: 436 LSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCS-IQSAPPEPATLKGTVP 494
S D E S +E E S++A+P P + + + + P + +V
Sbjct: 436 SSSGSDSE--SESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVD 493
Query: 495 DDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKD 554
+ + S G K+ E G KE G +TI + +
Sbjct: 494 SN----IPSSQGYKKEGREQGTGNSYTDTSGPKETSSATPGRDSKTIQ-----KGSESGR 544
Query: 555 GKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAST 614
G+ P +S + +E + + LK E S + S +
Sbjct: 545 GRQKSPAQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAA 604
Query: 615 TQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGER 674
T+ P +S K S + K +E + + +
Sbjct: 605 TKGSRKPNIKKES---------KSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDE 655
Query: 675 DDTIPPEYRHLLDDNGQDKPVKPPTKKSEDS------KKPADDQDPIDALSGDLDSCPST 728
+++PP + PVKP + + EDS P ++++ + LS D P
Sbjct: 656 SESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLI 715
Query: 729 TETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSK 768
+ N K ++ PK G K K T E K
Sbjct: 716 VKIDLNLLTRIPGKPYKETEPPK-GEKKNVPEKHTREAQK 754
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 67.0 bits (162), Expect = 6e-11
Identities = 101/401 (25%), Positives = 155/401 (38%), Gaps = 65/401 (16%)
Query: 310 AAGKKTEKEESTEVLKAQSAGTVRSAAPP-------------QEKKRKVEKDTMSDQALE 356
AA +K E+ E+ E A V++ AP QE++ + ++ SDQA E
Sbjct: 491 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 550
Query: 357 ALSASLGT------RQAEPELDLRSIKEVDEAK---AKEEKLEKCGEDDETIPSEYRLKP 407
S G+ Q E E + + E EAK EEK E+ +E + KP
Sbjct: 551 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 610
Query: 408 ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE-ESKAAAPAP 466
K P P E+ P +S + ++ +S +EK P K+ E K +P
Sbjct: 611 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV- 669
Query: 467 VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD--SLGKKEADPEDGKPVMDKVKE 524
S P K VP VE +GK E E+ K +VKE
Sbjct: 670 --------------SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK----EVKE 711
Query: 525 KAKEEDREKLGEKEETIPPDYRLEE-VKD----------KDGKPLLPKESKEQLPPMSED 573
KEE EK EK + +P + E VK+ K K L KE+KE+ P+ ++
Sbjct: 712 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 771
Query: 574 FLLDAL-----SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSD 628
+ SE+ + A + ED + + E + T + G+ +
Sbjct: 772 KEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV-EGKEEVEQETKEKGS---GREEEK 827
Query: 629 KDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 669
+ + LD LS + ++ D E K + K EK +E D
Sbjct: 828 GVVTNGLD-LSPADEKKGGDKSEEKVVVTKTVEKITSEGGD 867
Score = 48.5 bits (114), Expect = 2e-05
Identities = 89/391 (22%), Positives = 138/391 (35%), Gaps = 52/391 (13%)
Query: 297 DALSSDFTCGSPTAAGKKTEKEESTE--VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQA 354
D L+ AA +K + E T G + + PP K++K +
Sbjct: 386 DLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPK 445
Query: 355 LEAL---------SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 405
L+ + ++E E L +I E KEEK E E +E +E
Sbjct: 446 LKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE 505
Query: 406 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK---------- 455
A K PE +E+ + E E +E E+ + ++ + +EK
Sbjct: 506 VAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE 565
Query: 456 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDG 515
EE + A A EA + ++ E AT + V D VE +K P
Sbjct: 566 QEEGETEAEAEGEEAEAKEEK-KVEEKSEEVATKEELVADAKVEK-----PEKAKSPVPK 619
Query: 516 KPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFL 575
PV +K K + E EK ++ P +EE K K P P E K + P
Sbjct: 620 SPVEEKGKSPVPKSPVE---EKGKSPVPKSPVEE-KGKSPVPKSPVEEKGKSPVSK---- 671
Query: 576 LDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDAL 635
+ E P S + E+AK A + + Q + P++ K+
Sbjct: 672 -SPVEEKAKSPVPKSPV--EEAKSKAEVGK-GEQKEEEEKEVKEAPKEEKVEKKE----- 722
Query: 636 DKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 666
++ D E K E VKE+A AE
Sbjct: 723 --------EKPKDVPEKKKAESPVKEEAVAE 745
Score = 46.2 bits (108), Expect = 1e-04
Identities = 69/345 (20%), Positives = 134/345 (38%), Gaps = 30/345 (8%)
Query: 103 LPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTE 162
+ +KK + + EPE + + K P +A+ + +K E+ E+ E
Sbjct: 484 MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEK----EEEEGQEEEEEE 539
Query: 163 PKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALD 222
+ D GG S K G +KE+ E++ + ++ + ++
Sbjct: 540 DEGAKSDQAEEGG---------SEKEGSSEKEEGEQEEG-ETEAEAEGEEAEAKEEKKVE 589
Query: 223 DLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGP 282
+ + + EE + + P+ + +EE GK V P E K P
Sbjct: 590 EKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPV--PKSPVEEKGKSPVPKSP 647
Query: 283 PADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKK 342
+ K P ++ SP K+ +S V +A+S V +E++
Sbjct: 648 VEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKS-PVEEAKSKAEVGKGEQKEEEE 706
Query: 343 RKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSE 402
++V K+ ++ +E ++ E D+ K+ E+ KEE + + +++ +
Sbjct: 707 KEV-KEAPKEEKVE--------KKEEKPKDVPEKKKA-ESPVKEEAVAEVVTITKSV--K 754
Query: 403 YRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKE 447
L+ T ++GKPL E +EK K E +E S+ + KE
Sbjct: 755 VHLEKETKEEGKPLQQE-KEKEKAGGEGGSEEEGSDKGAKGSRKE 798
Score = 40.8 bits (94), Expect = 0.005
Identities = 39/185 (21%), Positives = 71/185 (38%), Gaps = 6/185 (3%)
Query: 28 SEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPT 87
S + E + GE + E + A + + A+ ++ A + + +P
Sbjct: 558 SSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPV 617
Query: 88 ETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKA 147
+ + P P ++K K K+ E+K +S PKS + G + +K
Sbjct: 618 PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS---PVEEKGKSPV-SKSP 673
Query: 148 VSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPA-VPVES 206
V A + P KS + K + + G + + P ++K EKK P VP +
Sbjct: 674 VEEKA-KSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKK 732
Query: 207 KPDKP 211
K + P
Sbjct: 733 KAESP 737
Score = 31.2 bits (69), Expect = 3.8
Identities = 54/222 (24%), Positives = 87/222 (39%), Gaps = 39/222 (17%)
Query: 83 SMNPTETKA---IPVSQQME---------GPHLPNKKKHKKQAVKTEPEKKSQSTKPKSL 130
S +P E KA +P S E G ++K K+A K E +K + KPK +
Sbjct: 670 SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEE-KPKDV 728
Query: 131 P--KQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKP----QDMISAGGESVAGITAI 184
P K+A +A + + + EK T+ + KP ++ AGGE G
Sbjct: 729 PEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE--GGSEEE 786
Query: 185 SGKPGDKKKEKKSLTPAVPVESK-------PDKPSGK--------SGMDAALDDLIDTLG 229
G K K+ + VE K +K SG+ +G+D + D + G
Sbjct: 787 GSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPAD--EKKG 844
Query: 230 GPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRE 271
G + E+ T T +++ + + K VT+ K E
Sbjct: 845 GDKSEEKVVVTKTVEKITSEGGDGATKYITK-SVTVTQKVEE 885
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 67.0 bits (162), Expect = 6e-11
Identities = 101/401 (25%), Positives = 155/401 (38%), Gaps = 65/401 (16%)
Query: 310 AAGKKTEKEESTEVLKAQSAGTVRSAAPP-------------QEKKRKVEKDTMSDQALE 356
AA +K E+ E+ E A V++ AP QE++ + ++ SDQA E
Sbjct: 115 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174
Query: 357 ALSASLGT------RQAEPELDLRSIKEVDEAK---AKEEKLEKCGEDDETIPSEYRLKP 407
S G+ Q E E + + E EAK EEK E+ +E + KP
Sbjct: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234
Query: 408 ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE-ESKAAAPAP 466
K P P E+ P +S + ++ +S +EK P K+ E K +P
Sbjct: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV- 293
Query: 467 VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD--SLGKKEADPEDGKPVMDKVKE 524
S P K VP VE +GK E E+ K +VKE
Sbjct: 294 --------------SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK----EVKE 335
Query: 525 KAKEEDREKLGEKEETIPPDYRLEE-VKD----------KDGKPLLPKESKEQLPPMSED 573
KEE EK EK + +P + E VK+ K K L KE+KE+ P+ ++
Sbjct: 336 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 395
Query: 574 FLLDAL-----SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSD 628
+ SE+ + A + ED + + E + T + G+ +
Sbjct: 396 KEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV-EGKEEVEQETKEKGS---GREEEK 451
Query: 629 KDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 669
+ + LD LS + ++ D E K + K EK +E D
Sbjct: 452 GVVTNGLD-LSPADEKKGGDKSEEKVVVTKTVEKITSEGGD 491
Score = 48.5 bits (114), Expect = 2e-05
Identities = 89/391 (22%), Positives = 138/391 (35%), Gaps = 52/391 (13%)
Query: 297 DALSSDFTCGSPTAAGKKTEKEESTE--VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQA 354
D L+ AA +K + E T G + + PP K++K +
Sbjct: 10 DLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPK 69
Query: 355 LEAL---------SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 405
L+ + ++E E L +I E KEEK E E +E +E
Sbjct: 70 LKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE 129
Query: 406 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK---------- 455
A K PE +E+ + E E +E E+ + ++ + +EK
Sbjct: 130 VAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE 189
Query: 456 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDG 515
EE + A A EA + ++ E AT + V D VE +K P
Sbjct: 190 QEEGETEAEAEGEEAEAKEEK-KVEEKSEEVATKEELVADAKVEK-----PEKAKSPVPK 243
Query: 516 KPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFL 575
PV +K K + E EK ++ P +EE K K P P E K + P
Sbjct: 244 SPVEEKGKSPVPKSPVE---EKGKSPVPKSPVEE-KGKSPVPKSPVEEKGKSPVSK---- 295
Query: 576 LDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDAL 635
+ E P S + E+AK A + + Q + P++ K+
Sbjct: 296 -SPVEEKAKSPVPKSPV--EEAKSKAEVGK-GEQKEEEEKEVKEAPKEEKVEKKE----- 346
Query: 636 DKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 666
++ D E K E VKE+A AE
Sbjct: 347 --------EKPKDVPEKKKAESPVKEEAVAE 369
Score = 46.2 bits (108), Expect = 1e-04
Identities = 69/345 (20%), Positives = 134/345 (38%), Gaps = 30/345 (8%)
Query: 103 LPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTE 162
+ +KK + + EPE + + K P +A+ + +K E+ E+ E
Sbjct: 108 MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEK----EEEEGQEEEEEE 163
Query: 163 PKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALD 222
+ D GG S K G +KE+ E++ + ++ + ++
Sbjct: 164 DEGAKSDQAEEGG---------SEKEGSSEKEEGEQEEG-ETEAEAEGEEAEAKEEKKVE 213
Query: 223 DLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGP 282
+ + + EE + + P+ + +EE GK V P E K P
Sbjct: 214 EKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPV--PKSPVEEKGKSPVPKSP 271
Query: 283 PADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKK 342
+ K P ++ SP K+ +S V +A+S V +E++
Sbjct: 272 VEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKS-PVEEAKSKAEVGKGEQKEEEE 330
Query: 343 RKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSE 402
++V K+ ++ +E ++ E D+ K+ E+ KEE + + +++ +
Sbjct: 331 KEV-KEAPKEEKVE--------KKEEKPKDVPEKKKA-ESPVKEEAVAEVVTITKSV--K 378
Query: 403 YRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKE 447
L+ T ++GKPL E +EK K E +E S+ + KE
Sbjct: 379 VHLEKETKEEGKPLQQE-KEKEKAGGEGGSEEEGSDKGAKGSRKE 422
Score = 40.8 bits (94), Expect = 0.005
Identities = 39/185 (21%), Positives = 71/185 (38%), Gaps = 6/185 (3%)
Query: 28 SEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPT 87
S + E + GE + E + A + + A+ ++ A + + +P
Sbjct: 182 SSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPV 241
Query: 88 ETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKA 147
+ + P P ++K K K+ E+K +S PKS + G + +K
Sbjct: 242 PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS---PVEEKGKSPV-SKSP 297
Query: 148 VSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPA-VPVES 206
V A + P KS + K + + G + + P ++K EKK P VP +
Sbjct: 298 VEEKA-KSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKK 356
Query: 207 KPDKP 211
K + P
Sbjct: 357 KAESP 361
Score = 31.2 bits (69), Expect = 3.8
Identities = 54/222 (24%), Positives = 87/222 (39%), Gaps = 39/222 (17%)
Query: 83 SMNPTETKA---IPVSQQME---------GPHLPNKKKHKKQAVKTEPEKKSQSTKPKSL 130
S +P E KA +P S E G ++K K+A K E +K + KPK +
Sbjct: 294 SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEE-KPKDV 352
Query: 131 P--KQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKP----QDMISAGGESVAGITAI 184
P K+A +A + + + EK T+ + KP ++ AGGE G
Sbjct: 353 PEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE--GGSEEE 410
Query: 185 SGKPGDKKKEKKSLTPAVPVESK-------PDKPSGK--------SGMDAALDDLIDTLG 229
G K K+ + VE K +K SG+ +G+D + D + G
Sbjct: 411 GSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPAD--EKKG 468
Query: 230 GPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRE 271
G + E+ T T +++ + + K VT+ K E
Sbjct: 469 GDKSEEKVVVTKTVEKITSEGGDGATKYITK-SVTVTQKVEE 509
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 67.0 bits (162), Expect = 6e-11
Identities = 129/645 (20%), Positives = 239/645 (37%), Gaps = 108/645 (16%)
Query: 97 QMEGPHLPNKKKHKKQAVKTE-PEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQ 155
+++ P L K+ HK + K E PE+K Q+ K K+ +K ++ ++
Sbjct: 132 EIDEPPLRKKEIHKDKTEKQEKPERKIQT---KVTHKEKEKGKEKVREKEKPEKKATHKE 188
Query: 156 PSEKSTEPKTKP---QDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPS 212
EK +P+TK + + E T K G ++K K++ V+ P KP
Sbjct: 189 KIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPK 248
Query: 213 GKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYRE 271
E+ ++E + E D + Y+ ++ + +
Sbjct: 249 -------------------EKEDKEKAAVSKHEQKDQYAFCRYMIDIFV--------HGD 281
Query: 272 LLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGT 331
L + PP + + P A AL KK EK+ ++E K +
Sbjct: 282 LKPGQSPAIPPPLPTEQASRPTPASPALEEK------EGEKKKAEKKVTSETKKKEK--- 332
Query: 332 VRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEK 391
++ K+K EK+T D + + T+Q ++ ++ + DE K +K +K
Sbjct: 333 -------EDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKK 385
Query: 392 CGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS-ECKEKPS 450
P+E ++ K EP + PK E S D+ + K + +
Sbjct: 386 --------PAEVEQPKGKKQEKKEKHVEPAKSPK--------KEHSVPSDKQVKAKTERA 429
Query: 451 KPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEA 510
K K A P E +T I+ K ++ GK+E
Sbjct: 430 KEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKE-------KSGKTSSILKDKEPIKGKEEK 482
Query: 511 DPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPM 570
P K +K E K+E K G++ + PP +L+ K++ +P + KE+K P +
Sbjct: 483 VPASLK---EKEPETKKDEKMSKAGKEVKPKPP--QLQGKKEEKPEPQIKKEAK---PAI 534
Query: 571 SEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKD 630
SE + +D P+ S + K V+ Q A T + A P+ T +++
Sbjct: 535 SEKVQIH--KQDIVKPEKTVSHGKPEEK-------VLKQVKAVTIEKTAKPKPTKKAEH- 584
Query: 631 LDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNG 690
++ S+ +P P E K K E + E++ + +HL ++
Sbjct: 585 ----REREPPSIKTDKPKPTPKGTSEVTESGKKKTE----ISEKESKEKADMKHLREEKV 636
Query: 691 QDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNT 735
+ ++KPA +S D++ P++ + + T
Sbjct: 637 STRKESLQLHNVTKAEKPA-------RVSKDVEDVPASKKAKEGT 674
Score = 66.6 bits (161), Expect = 8e-11
Identities = 133/607 (21%), Positives = 221/607 (36%), Gaps = 84/607 (13%)
Query: 7 KPAASPRPRRAAAARRTH-------EHVSEKTSESPSKPGEKKGSDEKK----AASLGSS 55
K +P R + TH E V EK E P K K EKK +L
Sbjct: 147 KTEKQEKPERKIQTKVTHKEKEKGKEKVREK--EKPEKKATHKEKIEKKEKPETKTLAKE 204
Query: 56 QSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVK 115
Q A + TK G K + A V + + P P +K+ K++A
Sbjct: 205 QKKAKTAEKSEEKTKKEVKGGKQEK------VKQTAAKVKEVQKTPSKPKEKEDKEKAAV 258
Query: 116 TEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGG 175
++ E+K Q + + + + +P + P P + S
Sbjct: 259 SKHEQKDQYAFCRYMID---------------IFVHGDLKPGQSPAIPPPLPTEQAS--- 300
Query: 176 ESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETE 235
A+ K G+KKK +K +T + K D KS + A+D G ET+
Sbjct: 301 RPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKK-KSEKETAIDVEKKEPGKASETK 359
Query: 236 EENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDA 295
+ + + K+ + + KKE P K
Sbjct: 360 QGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKE------ 413
Query: 296 IDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQAL 355
++ SD + T K E+ + + KA E++ + EK + L
Sbjct: 414 -HSVPSDKQVKAKTERAK--EEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSIL 470
Query: 356 EALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKP 415
+ G + P S+KE + K+EK+ K G++ + P + + K K+ KP
Sbjct: 471 KDKEPIKGKEEKVP----ASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGK----KEEKP 522
Query: 416 LLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEE-------SKAAAPAPVS 468
P+ +++ KP + SE + +D + E KP EK + K A P P
Sbjct: 523 -EPQIKKEAKP-AISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTK 580
Query: 469 EAVCR-TSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAK 527
+A R SI++ P+P T KGT + E+ GKK+ + + + K K K
Sbjct: 581 KAEHREREPPSIKTDKPKP-TPKGT--SEVTES-----GKKKTEISEKE---SKEKADMK 629
Query: 528 EEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ 587
EK+ ++E++ +L V K KP + E +P + +ED S +
Sbjct: 630 HLREEKVSTRKESL----QLHNV-TKAEKPARVSKDVEDVPASKK---AKEGTEDVSPTK 681
Query: 588 NASSLKF 594
S + F
Sbjct: 682 QKSPISF 688
Score = 63.9 bits (154), Expect = 5e-10
Identities = 99/439 (22%), Positives = 161/439 (36%), Gaps = 77/439 (17%)
Query: 3 QPGQKPAASPRPRRAAAARRTHEHVSEKTSESPS---KPGEKKGSDEKKAASLGSSQSSR 59
+PGQ PA P E S T SP+ K GEKK + EKK S +
Sbjct: 283 KPGQSPAIPP--------PLPTEQASRPTPASPALEEKEGEKKKA-EKKVTSETKKKEKE 333
Query: 60 TYAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPE 119
+ T + K+S K + + + KK KK A +P+
Sbjct: 334 DIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPK 393
Query: 120 KKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQ-PSEKSTEPKTKPQDMISAGGESV 178
K Q K K H + A S E PS+K + KT+ E +
Sbjct: 394 GKKQEKKEK--------------HVEPAKSPKKEHSVPSDKQVKAKTE------RAKEEI 433
Query: 179 AGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEEN 238
++ PG KKE+K+ T V E + +K SGK+ + L D + + G EE +
Sbjct: 434 GAVSIKKAVPG--KKEEKT-TKTVEQEIRKEK-SGKT--SSILKDK-EPIKGKEEKVPAS 486
Query: 239 TTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDA 298
PE E++ K + PK +L KKE P + +
Sbjct: 487 LKEKEPETKKD------EKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQI 540
Query: 299 LSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKR-----------KVEK 347
D T + K E+ +VLK A T+ A P+ K+ K +K
Sbjct: 541 HKQDIVKPEKTVSHGKPEE----KVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDK 596
Query: 348 DTMSDQALEALSAS------LGTRQAEPELDLRSIKEVDEAKAKE----------EKLEK 391
+ + ++ S + ++++ + D++ ++E + KE EK +
Sbjct: 597 PKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPAR 656
Query: 392 CGEDDETIPSEYRLKPATD 410
+D E +P+ + K T+
Sbjct: 657 VSKDVEDVPASKKAKEGTE 675
Score = 43.9 bits (102), Expect = 6e-04
Identities = 65/307 (21%), Positives = 110/307 (35%), Gaps = 59/307 (19%)
Query: 488 TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRL 547
T KG + + + K E + + + KV K KE+ +EK+ EKE+
Sbjct: 128 TDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHK 187
Query: 548 EEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVV 607
E+++ K+ KP +KEQ + + + ++ G K E K AA + V
Sbjct: 188 EKIEKKE-KPETKTLAKEQKKAKTAEKSEEKTKKEVKGG------KQEKVKQTAAKVKEV 240
Query: 608 SQTPASTTQAGAPPRDTSQSDKDLD---------------DALDKLSDSLGQRQPDPDEN 652
+TP+ + + + D D S ++ P +
Sbjct: 241 QKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS 300
Query: 653 KP------MEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK--SED 704
+P +E+K EK KAE K V TKK ED
Sbjct: 301 RPTPASPALEEKEGEKKKAE--------------------------KKVTSETKKKEKED 334
Query: 705 SKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTE 764
KK ++ + ID + +ET Q T K + AA + ++ K K A+ +
Sbjct: 335 IKKKSEKETAIDV---EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQ 391
Query: 765 ETSKPKD 771
K ++
Sbjct: 392 PKGKKQE 398
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 64.7 bits (156), Expect = 3e-10
Identities = 148/756 (19%), Positives = 245/756 (32%), Gaps = 72/756 (9%)
Query: 37 KPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSG-----ATSKSSSMNPTETKA 91
+P SD K SL ++ + T + K +++ G + ++ S+ T K
Sbjct: 127 RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD 186
Query: 92 IPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRS 151
+ + ++ P + K T P++ + +T PK P + K A +
Sbjct: 187 LAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTT-PKE-PASTTPKEPTPTTIKSAPTTP 244
Query: 152 AEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKP 211
E P+ + P T P++ + A T P K+ + T + P K P
Sbjct: 245 KEPAPTTTKSAPTT-PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP 303
Query: 212 SGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRE 271
+ T P T + T P+ P + K PK
Sbjct: 304 T--------------TPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA 349
Query: 272 LLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGT 331
A K+ P + + P P + + + + +P T K T + T
Sbjct: 350 PTAPKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT 408
Query: 332 VRSAAPPQEKKRKVEKD----TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEE 387
+ P+E K+ T + A T EP + KE K+
Sbjct: 409 KSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKP 466
Query: 388 KLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDR 442
E T P E P T K P PE EKP P + EL E+
Sbjct: 467 APTTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE--- 521
Query: 443 SECKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVE 499
P+ P E + KAAAP E T + P EPA T K T P +
Sbjct: 522 ----PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-K 576
Query: 500 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 559
A + K+ A KP ++ +E +K P K P
Sbjct: 577 GTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTT 627
Query: 560 PKES-----KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAST 614
PKE KE P + L E P + K +LA ++ + T +
Sbjct: 628 PKEPAPTTPKEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDK 683
Query: 615 TQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGER 674
P + K+ K P P ++ ++ H+
Sbjct: 684 PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP---- 739
Query: 675 DDTIPPEYRHLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTET 731
D++ P ++ P +P PT K+ + KP D + DL + P TT
Sbjct: 740 DESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTA 799
Query: 732 SQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETS 767
+ K+ ++++ + ++ TT++T+
Sbjct: 800 APKMTKETATTTEKTTESKITATTTQVTSTTTQDTT 835
Score = 50.4 bits (119), Expect = 6e-06
Identities = 101/497 (20%), Positives = 164/497 (32%), Gaps = 36/497 (7%)
Query: 288 KPIGPDDAIDALSS-DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE 346
KP D+A L + DF +P + + K ++ + R + PP K
Sbjct: 81 KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 140
Query: 347 KDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 405
T++ + +E + +Q + KE + + + +EK D S+
Sbjct: 141 SLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLA 195
Query: 406 KPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 462
KP + P L P+E P P + E ++ + K P+ P E + +
Sbjct: 196 KPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKS 254
Query: 463 APAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKV 522
AP E T+ + P EPA P A + K+ A KP
Sbjct: 255 APTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 314
Query: 523 KEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLPPMSEDFLL 576
KE A +E +E P K+ P PK+ KE P ++
Sbjct: 315 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAP 374
Query: 577 DALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS-QSDKDLDD 633
E + + E A + ++ PA TT AP P++ S + K+
Sbjct: 375 TTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 428
Query: 634 ALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 692
K ++P P K P KE A + + T P E
Sbjct: 429 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAPTTPKETAP 484
Query: 693 KPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKN 752
K T + + P + P +L P+T E T ++ + AP
Sbjct: 485 TTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTTPKAAAPNT 542
Query: 753 GGKAKDSAKTTEETSKP 769
K+ A TT + P
Sbjct: 543 ---PKEPAPTTPKEPAP 556
Score = 47.0 bits (110), Expect = 7e-05
Identities = 121/610 (19%), Positives = 200/610 (32%), Gaps = 92/610 (15%)
Query: 7 KPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTA 66
K A P+ A + +P+ P E + KK + + T A
Sbjct: 448 KEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 507
Query: 67 SATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTK 126
T + + + P E P + + P+ P K+ T P++ + +T
Sbjct: 508 PTTPEELAPTTPEEPTPTTPEEPA--PTTPKAAAPNTP------KEPAPTTPKEPAPTTP 559
Query: 127 PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISG 186
+ P +T K + + ++P+ +T K P+++ + T
Sbjct: 560 KEPAPTTPKETAPT---TPKGTAPTTLKEPAP-TTPKKPAPKELAPTTTKEPTSTTCDKP 615
Query: 187 KP----GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 242
P G K P P E P P G + + T P E TT
Sbjct: 616 APTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPKKPAPKELAPTTTK 674
Query: 243 GPE--VSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS 300
GP SD + T +E T P + KK T P P +S
Sbjct: 675 GPTSTTSDKPAPTTPKETAP---TTPKEPAPTTPKKPAPTTPET-------PPPTTSEVS 724
Query: 301 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP-----PQEKKRKVEKDTMSDQAL 355
+ T PT K + EST L A+ +P P K K M+ A
Sbjct: 725 TPTTTKEPTTIHKSPD--ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAK 782
Query: 356 EALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEY-----RLKPATD 410
+ + E DLR+ E A K K E ++T S+ ++ T
Sbjct: 783 DKTT----------ERDLRTTPETTTAAPKMTK-ETATTTEKTTESKITATTTQVTSTTT 831
Query: 411 KDGKP----------LLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESK 460
+D P L P+ K + +E++++ E+ +KP ++ SK
Sbjct: 832 QDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK----------PEETAKPKDRATNSK 881
Query: 461 AAAPAPVSEAVCRTSMCSIQ-----------SAPPEPATLKGTVPD-DAVEALADSLGKK 508
A P P S + P P + T+P+ + +A+++ +
Sbjct: 882 ATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQT 941
Query: 509 EADPEDGKPVMDKVKEKAKEEDREKLGEKEET-----IPPDYRLEEVKDKDGKPLLPKES 563
P P V+ K ED G + ET P + E D D P +P +
Sbjct: 942 TTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQG 998
Query: 564 KEQLPPMSED 573
P +S++
Sbjct: 999 IIINPMLSDE 1008
Score = 44.3 bits (103), Expect = 4e-04
Identities = 57/267 (21%), Positives = 93/267 (34%), Gaps = 15/267 (5%)
Query: 280 TGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 339
T P ++KPI P ++ S S T + T + + T Q++ +
Sbjct: 114 TSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSA 173
Query: 340 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 399
++ + +EK + D A + + T +AE ++ E K E
Sbjct: 174 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 233
Query: 400 PSEYRLKPATDKDGKPL------------LPEPEEKPKPRSESELIDELSEDFDRSECKE 447
P+ + P T K+ P P ++P P + E +++ + K
Sbjct: 234 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 293
Query: 448 KPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA-TLKGTVPDDAVEALADSL 505
P+ P E + K AP E T + P EPA T K P E A +
Sbjct: 294 APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP-APTA 352
Query: 506 GKKEADPEDGKPVMDKVKEKAKEEDRE 532
KK A +P KE A +E
Sbjct: 353 PKKPAPTTPKEPAPTTPKEPAPTTTKE 379
Score = 32.0 bits (71), Expect = 2.2
Identities = 54/255 (21%), Positives = 93/255 (36%), Gaps = 21/255 (8%)
Query: 524 EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDF 583
E+ +E D + +K + PDY + KD K K+ PP+ + E
Sbjct: 38 ERGRECDCDAQCKKYDKCCPDYESFCAEVKDNKKNRTKKKPTPKPPV--------VDEAG 89
Query: 584 SGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT--SQSDKDLDDALDKLSDS 641
SG N K + VS +P TT PR + SD + +L ++
Sbjct: 90 SGLDN-GDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKET 148
Query: 642 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDT--IPPEYRHLLDDNGQ-DKPVKPP 698
+ + NK KEK + + E+ + P + L + + K P
Sbjct: 149 TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP 208
Query: 699 TKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKC----KKAASSSKAPKNGG 754
+ P ++P A + + P+T +++ T K+ K A ++ K P
Sbjct: 209 ALTTPKEPTPTTPKEP--ASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA-PT 265
Query: 755 KAKDSAKTTEETSKP 769
K+ A TT + P
Sbjct: 266 TTKEPAPTTPKEPAP 280
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 64.7 bits (156), Expect = 3e-10
Identities = 148/756 (19%), Positives = 245/756 (32%), Gaps = 72/756 (9%)
Query: 37 KPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSG-----ATSKSSSMNPTETKA 91
+P SD K SL ++ + T + K +++ G + ++ S+ T K
Sbjct: 168 RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD 227
Query: 92 IPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRS 151
+ + ++ P + K T P++ + +T PK P + K A +
Sbjct: 228 LAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTT-PKE-PASTTPKEPTPTTIKSAPTTP 285
Query: 152 AEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKP 211
E P+ + P T P++ + A T P K+ + T + P K P
Sbjct: 286 KEPAPTTTKSAPTT-PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP 344
Query: 212 SGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRE 271
+ T P T + T P+ P + K PK
Sbjct: 345 T--------------TPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA 390
Query: 272 LLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGT 331
A K+ P + + P P + + + + +P T K T + T
Sbjct: 391 PTAPKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT 449
Query: 332 VRSAAPPQEKKRKVEKD----TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEE 387
+ P+E K+ T + A T EP + KE K+
Sbjct: 450 KSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKP 507
Query: 388 KLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDR 442
E T P E P T K P PE EKP P + EL E+
Sbjct: 508 APTTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE--- 562
Query: 443 SECKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVE 499
P+ P E + KAAAP E T + P EPA T K T P +
Sbjct: 563 ----PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-K 617
Query: 500 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 559
A + K+ A KP ++ +E +K P K P
Sbjct: 618 GTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTT 668
Query: 560 PKES-----KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAST 614
PKE KE P + L E P + K +LA ++ + T +
Sbjct: 669 PKEPAPTTPKEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDK 724
Query: 615 TQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGER 674
P + K+ K P P ++ ++ H+
Sbjct: 725 PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP---- 780
Query: 675 DDTIPPEYRHLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTET 731
D++ P ++ P +P PT K+ + KP D + DL + P TT
Sbjct: 781 DESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTA 840
Query: 732 SQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETS 767
+ K+ ++++ + ++ TT++T+
Sbjct: 841 APKMTKETATTTEKTTESKITATTTQVTSTTTQDTT 876
Score = 50.4 bits (119), Expect = 6e-06
Identities = 101/497 (20%), Positives = 164/497 (32%), Gaps = 36/497 (7%)
Query: 288 KPIGPDDAIDALSS-DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE 346
KP D+A L + DF +P + + K ++ + R + PP K
Sbjct: 122 KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 181
Query: 347 KDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 405
T++ + +E + +Q + KE + + + +EK D S+
Sbjct: 182 SLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLA 236
Query: 406 KPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 462
KP + P L P+E P P + E ++ + K P+ P E + +
Sbjct: 237 KPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKS 295
Query: 463 APAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKV 522
AP E T+ + P EPA P A + K+ A KP
Sbjct: 296 APTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 355
Query: 523 KEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLPPMSEDFLL 576
KE A +E +E P K+ P PK+ KE P ++
Sbjct: 356 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAP 415
Query: 577 DALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS-QSDKDLDD 633
E + + E A + ++ PA TT AP P++ S + K+
Sbjct: 416 TTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 469
Query: 634 ALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 692
K ++P P K P KE A + + T P E
Sbjct: 470 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAPTTPKETAP 525
Query: 693 KPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKN 752
K T + + P + P +L P+T E T ++ + AP
Sbjct: 526 TTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTTPKAAAPNT 583
Query: 753 GGKAKDSAKTTEETSKP 769
K+ A TT + P
Sbjct: 584 ---PKEPAPTTPKEPAP 597
Score = 47.0 bits (110), Expect = 7e-05
Identities = 121/610 (19%), Positives = 200/610 (32%), Gaps = 92/610 (15%)
Query: 7 KPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTA 66
K A P+ A + +P+ P E + KK + + T A
Sbjct: 489 KEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 548
Query: 67 SATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTK 126
T + + + P E P + + P+ P K+ T P++ + +T
Sbjct: 549 PTTPEELAPTTPEEPTPTTPEEPA--PTTPKAAAPNTP------KEPAPTTPKEPAPTTP 600
Query: 127 PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISG 186
+ P +T K + + ++P+ +T K P+++ + T
Sbjct: 601 KEPAPTTPKETAPT---TPKGTAPTTLKEPAP-TTPKKPAPKELAPTTTKEPTSTTCDKP 656
Query: 187 KP----GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 242
P G K P P E P P G + + T P E TT
Sbjct: 657 APTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPKKPAPKELAPTTTK 715
Query: 243 GPE--VSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS 300
GP SD + T +E T P + KK T P P +S
Sbjct: 716 GPTSTTSDKPAPTTPKETAP---TTPKEPAPTTPKKPAPTTPET-------PPPTTSEVS 765
Query: 301 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP-----PQEKKRKVEKDTMSDQAL 355
+ T PT K + EST L A+ +P P K K M+ A
Sbjct: 766 TPTTTKEPTTIHKSPD--ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAK 823
Query: 356 EALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEY-----RLKPATD 410
+ + E DLR+ E A K K E ++T S+ ++ T
Sbjct: 824 DKTT----------ERDLRTTPETTTAAPKMTK-ETATTTEKTTESKITATTTQVTSTTT 872
Query: 411 KDGKP----------LLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESK 460
+D P L P+ K + +E++++ E+ +KP ++ SK
Sbjct: 873 QDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK----------PEETAKPKDRATNSK 922
Query: 461 AAAPAPVSEAVCRTSMCSIQ-----------SAPPEPATLKGTVPD-DAVEALADSLGKK 508
A P P S + P P + T+P+ + +A+++ +
Sbjct: 923 ATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQT 982
Query: 509 EADPEDGKPVMDKVKEKAKEEDREKLGEKEET-----IPPDYRLEEVKDKDGKPLLPKES 563
P P V+ K ED G + ET P + E D D P +P +
Sbjct: 983 TTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQG 1039
Query: 564 KEQLPPMSED 573
P +S++
Sbjct: 1040 IIINPMLSDE 1049
Score = 44.3 bits (103), Expect = 4e-04
Identities = 57/267 (21%), Positives = 93/267 (34%), Gaps = 15/267 (5%)
Query: 280 TGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 339
T P ++KPI P ++ S S T + T + + T Q++ +
Sbjct: 155 TSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSA 214
Query: 340 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 399
++ + +EK + D A + + T +AE ++ E K E
Sbjct: 215 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 274
Query: 400 PSEYRLKPATDKDGKPL------------LPEPEEKPKPRSESELIDELSEDFDRSECKE 447
P+ + P T K+ P P ++P P + E +++ + K
Sbjct: 275 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 334
Query: 448 KPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA-TLKGTVPDDAVEALADSL 505
P+ P E + K AP E T + P EPA T K P E A +
Sbjct: 335 APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP-APTA 393
Query: 506 GKKEADPEDGKPVMDKVKEKAKEEDRE 532
KK A +P KE A +E
Sbjct: 394 PKKPAPTTPKEPAPTTPKEPAPTTTKE 420
Score = 32.0 bits (71), Expect = 2.2
Identities = 54/255 (21%), Positives = 93/255 (36%), Gaps = 21/255 (8%)
Query: 524 EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDF 583
E+ +E D + +K + PDY + KD K K+ PP+ + E
Sbjct: 79 ERGRECDCDAQCKKYDKCCPDYESFCAEVKDNKKNRTKKKPTPKPPV--------VDEAG 130
Query: 584 SGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT--SQSDKDLDDALDKLSDS 641
SG N K + VS +P TT PR + SD + +L ++
Sbjct: 131 SGLDN-GDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKET 189
Query: 642 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDT--IPPEYRHLLDDNGQ-DKPVKPP 698
+ + NK KEK + + E+ + P + L + + K P
Sbjct: 190 TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP 249
Query: 699 TKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKC----KKAASSSKAPKNGG 754
+ P ++P A + + P+T +++ T K+ K A ++ K P
Sbjct: 250 ALTTPKEPTPTTPKEP--ASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA-PT 306
Query: 755 KAKDSAKTTEETSKP 769
K+ A TT + P
Sbjct: 307 TTKEPAPTTPKEPAP 321
>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
Length = 1363
Score = 64.7 bits (156), Expect = 3e-10
Identities = 148/756 (19%), Positives = 245/756 (32%), Gaps = 72/756 (9%)
Query: 37 KPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSG-----ATSKSSSMNPTETKA 91
+P SD K SL ++ + T + K +++ G + ++ S+ T K
Sbjct: 220 RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD 279
Query: 92 IPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRS 151
+ + ++ P + K T P++ + +T PK P + K A +
Sbjct: 280 LAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTT-PKE-PASTTPKEPTPTTIKSAPTTP 337
Query: 152 AEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKP 211
E P+ + P T P++ + A T P K+ + T + P K P
Sbjct: 338 KEPAPTTTKSAPTT-PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP 396
Query: 212 SGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRE 271
+ T P T + T P+ P + K PK
Sbjct: 397 T--------------TPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA 442
Query: 272 LLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGT 331
A K+ P + + P P + + + + +P T K T + T
Sbjct: 443 PTAPKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT 501
Query: 332 VRSAAPPQEKKRKVEKD----TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEE 387
+ P+E K+ T + A T EP + KE K+
Sbjct: 502 KSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKP 559
Query: 388 KLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDR 442
E T P E P T K P PE EKP P + EL E+
Sbjct: 560 APTTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE--- 614
Query: 443 SECKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVE 499
P+ P E + KAAAP E T + P EPA T K T P +
Sbjct: 615 ----PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-K 669
Query: 500 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 559
A + K+ A KP ++ +E +K P K P
Sbjct: 670 GTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTT 720
Query: 560 PKES-----KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAST 614
PKE KE P + L E P + K +LA ++ + T +
Sbjct: 721 PKEPAPTTPKEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDK 776
Query: 615 TQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGER 674
P + K+ K P P ++ ++ H+
Sbjct: 777 PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP---- 832
Query: 675 DDTIPPEYRHLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTET 731
D++ P ++ P +P PT K+ + KP D + DL + P TT
Sbjct: 833 DESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTA 892
Query: 732 SQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETS 767
+ K+ ++++ + ++ TT++T+
Sbjct: 893 APKMTKETATTTEKTTESKITATTTQVTSTTTQDTT 928
Score = 57.8 bits (138), Expect = 4e-08
Identities = 192/932 (20%), Positives = 288/932 (30%), Gaps = 200/932 (21%)
Query: 8 PAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKG---------SDEKKAASLGSSQSS 58
P + P ++A + + T SP P +KK ++E + S SS
Sbjct: 69 PTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSS 128
Query: 59 RTYAGGTASATKVSASSGATS----------KSSSMNPTETKAIPVSQQME--GPHL--- 103
+ + +++ K+ +S + + K + N T+ K P ++ G L
Sbjct: 129 SSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNG 188
Query: 104 ------PNKKKHKKQAVKTEPE---KKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQ 154
P+ + V T P+ K + +P P + ++ NK+ + E
Sbjct: 189 DFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKET 248
Query: 155 QPSEK--STEPKTK------PQDMISAGGESVAGITAISGKPGDK------------KKE 194
+ K ST+ K K Q + + +A + + KP K KE
Sbjct: 249 TTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKE 308
Query: 195 KKSLTPAVPVESKPDKPSG---KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVS---- 247
TP P + P +P+ KS + T T +E T E +
Sbjct: 309 PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTP 368
Query: 248 -DPMSSTYIE---ELGKREVTIPPKYRELLAKKEGITGP------------------PAD 285
+P +T E K T P + KK T P PA
Sbjct: 369 KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAP 428
Query: 286 SSK---PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP----- 337
++K P P + +P T KE + K S T + AP
Sbjct: 429 TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKS 488
Query: 338 -PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLR------------SIKEVDEAKA 384
P K T S + T++ P + KE
Sbjct: 489 APTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTP 548
Query: 385 KEEKLEKCGEDDETIPSEYRLKPATDKDGKP-------------LLPEPEEKPKPRSESE 431
KE + T P E P T K+ P L P EKP P + E
Sbjct: 549 KEPAPTTTKKPAPTTPKE--PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 606
Query: 432 LIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPA--TL 489
L E+ P +P T KAAAP E T + P EPA T
Sbjct: 607 LAPTTPEE----PTPTTPEEPAPTT--PKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 660
Query: 490 KGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEE 549
K T P + A + K+ A KP ++ +E +K P
Sbjct: 661 KETAP-TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK-GTAP 718
Query: 550 VKDKDGKPLLPKESKEQLPPMSEDFLL--------------DALSEDFSGPQNASSLKFE 595
K+ P PKE P + L + GP + +S
Sbjct: 719 TTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTS---- 774
Query: 596 DAKLAAAISEVVSQT-----------PASTTQAGAPP-----------RDTSQSDKDLDD 633
D E T PA TT PP ++ + K D+
Sbjct: 775 DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE 834
Query: 634 ALDKLSDSLGQRQPDPDENKPMEDKV---------KEKAKAEHRDKLGERDDTIPPEYRH 684
+ +LS + P EN P E V K + +DK ERD PE
Sbjct: 835 STPELS---AEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTT 891
Query: 685 LLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAA 744
K T+K+ +SK A + T+ T+Q+T K
Sbjct: 892 AAPK--MTKETATTTEKTTESKITA-------------TTTQVTSTTTQDTTPFKITTLK 936
Query: 745 SSSKAPKNGGKAKDSAKT-----TEETSKPKD 771
+++ APK K T EET+KPKD
Sbjct: 937 TTTLAPKVTTTKKTITTTEIMNKPEETAKPKD 968
Score = 47.0 bits (110), Expect = 7e-05
Identities = 121/610 (19%), Positives = 200/610 (32%), Gaps = 92/610 (15%)
Query: 7 KPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTA 66
K A P+ A + +P+ P E + KK + + T A
Sbjct: 541 KEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 600
Query: 67 SATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTK 126
T + + + P E P + + P+ P K+ T P++ + +T
Sbjct: 601 PTTPEELAPTTPEEPTPTTPEEPA--PTTPKAAAPNTP------KEPAPTTPKEPAPTTP 652
Query: 127 PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISG 186
+ P +T K + + ++P+ +T K P+++ + T
Sbjct: 653 KEPAPTTPKETAPT---TPKGTAPTTLKEPAP-TTPKKPAPKELAPTTTKEPTSTTCDKP 708
Query: 187 KP----GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 242
P G K P P E P P G + + T P E TT
Sbjct: 709 APTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPKKPAPKELAPTTTK 767
Query: 243 GPE--VSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS 300
GP SD + T +E T P + KK T P P +S
Sbjct: 768 GPTSTTSDKPAPTTPKETAP---TTPKEPAPTTPKKPAPTTPET-------PPPTTSEVS 817
Query: 301 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP-----PQEKKRKVEKDTMSDQAL 355
+ T PT K + EST L A+ +P P K K M+ A
Sbjct: 818 TPTTTKEPTTIHKSPD--ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAK 875
Query: 356 EALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEY-----RLKPATD 410
+ + E DLR+ E A K K E ++T S+ ++ T
Sbjct: 876 DKTT----------ERDLRTTPETTTAAPKMTK-ETATTTEKTTESKITATTTQVTSTTT 924
Query: 411 KDGKP----------LLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESK 460
+D P L P+ K + +E++++ E+ +KP ++ SK
Sbjct: 925 QDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK----------PEETAKPKDRATNSK 974
Query: 461 AAAPAPVSEAVCRTSMCSIQ-----------SAPPEPATLKGTVPD-DAVEALADSLGKK 508
A P P S + P P + T+P+ + +A+++ +
Sbjct: 975 ATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQT 1034
Query: 509 EADPEDGKPVMDKVKEKAKEEDREKLGEKEET-----IPPDYRLEEVKDKDGKPLLPKES 563
P P V+ K ED G + ET P + E D D P +P +
Sbjct: 1035 TTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQG 1091
Query: 564 KEQLPPMSED 573
P +S++
Sbjct: 1092 IIINPMLSDE 1101
>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
Length = 1404
Score = 64.7 bits (156), Expect = 3e-10
Identities = 148/756 (19%), Positives = 245/756 (32%), Gaps = 72/756 (9%)
Query: 37 KPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSG-----ATSKSSSMNPTETKA 91
+P SD K SL ++ + T + K +++ G + ++ S+ T K
Sbjct: 261 RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD 320
Query: 92 IPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRS 151
+ + ++ P + K T P++ + +T PK P + K A +
Sbjct: 321 LAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTT-PKE-PASTTPKEPTPTTIKSAPTTP 378
Query: 152 AEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKP 211
E P+ + P T P++ + A T P K+ + T + P K P
Sbjct: 379 KEPAPTTTKSAPTT-PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP 437
Query: 212 SGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRE 271
+ T P T + T P+ P + K PK
Sbjct: 438 T--------------TPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA 483
Query: 272 LLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGT 331
A K+ P + + P P + + + + +P T K T + T
Sbjct: 484 PTAPKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT 542
Query: 332 VRSAAPPQEKKRKVEKD----TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEE 387
+ P+E K+ T + A T EP + KE K+
Sbjct: 543 KSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKP 600
Query: 388 KLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDR 442
E T P E P T K P PE EKP P + EL E+
Sbjct: 601 APTTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE--- 655
Query: 443 SECKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVE 499
P+ P E + KAAAP E T + P EPA T K T P +
Sbjct: 656 ----PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-K 710
Query: 500 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 559
A + K+ A KP ++ +E +K P K P
Sbjct: 711 GTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTT 761
Query: 560 PKES-----KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAST 614
PKE KE P + L E P + K +LA ++ + T +
Sbjct: 762 PKEPAPTTPKEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDK 817
Query: 615 TQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGER 674
P + K+ K P P ++ ++ H+
Sbjct: 818 PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP---- 873
Query: 675 DDTIPPEYRHLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTET 731
D++ P ++ P +P PT K+ + KP D + DL + P TT
Sbjct: 874 DESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTA 933
Query: 732 SQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETS 767
+ K+ ++++ + ++ TT++T+
Sbjct: 934 APKMTKETATTTEKTTESKITATTTQVTSTTTQDTT 969
Score = 57.8 bits (138), Expect = 4e-08
Identities = 192/932 (20%), Positives = 288/932 (30%), Gaps = 200/932 (21%)
Query: 8 PAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKG---------SDEKKAASLGSSQSS 58
P + P ++A + + T SP P +KK ++E + S SS
Sbjct: 110 PTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSS 169
Query: 59 RTYAGGTASATKVSASSGATS----------KSSSMNPTETKAIPVSQQME--GPHL--- 103
+ + +++ K+ +S + + K + N T+ K P ++ G L
Sbjct: 170 SSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNG 229
Query: 104 ------PNKKKHKKQAVKTEPE---KKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQ 154
P+ + V T P+ K + +P P + ++ NK+ + E
Sbjct: 230 DFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKET 289
Query: 155 QPSEK--STEPKTK------PQDMISAGGESVAGITAISGKPGDK------------KKE 194
+ K ST+ K K Q + + +A + + KP K KE
Sbjct: 290 TTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKE 349
Query: 195 KKSLTPAVPVESKPDKPSG---KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVS---- 247
TP P + P +P+ KS + T T +E T E +
Sbjct: 350 PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTP 409
Query: 248 -DPMSSTYIE---ELGKREVTIPPKYRELLAKKEGITGP------------------PAD 285
+P +T E K T P + KK T P PA
Sbjct: 410 KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAP 469
Query: 286 SSK---PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP----- 337
++K P P + +P T KE + K S T + AP
Sbjct: 470 TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKS 529
Query: 338 -PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLR------------SIKEVDEAKA 384
P K T S + T++ P + KE
Sbjct: 530 APTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTP 589
Query: 385 KEEKLEKCGEDDETIPSEYRLKPATDKDGKP-------------LLPEPEEKPKPRSESE 431
KE + T P E P T K+ P L P EKP P + E
Sbjct: 590 KEPAPTTTKKPAPTTPKE--PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 647
Query: 432 LIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPA--TL 489
L E+ P +P T KAAAP E T + P EPA T
Sbjct: 648 LAPTTPEE----PTPTTPEEPAPTT--PKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 701
Query: 490 KGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEE 549
K T P + A + K+ A KP ++ +E +K P
Sbjct: 702 KETAP-TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK-GTAP 759
Query: 550 VKDKDGKPLLPKESKEQLPPMSEDFLL--------------DALSEDFSGPQNASSLKFE 595
K+ P PKE P + L + GP + +S
Sbjct: 760 TTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTS---- 815
Query: 596 DAKLAAAISEVVSQT-----------PASTTQAGAPP-----------RDTSQSDKDLDD 633
D E T PA TT PP ++ + K D+
Sbjct: 816 DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE 875
Query: 634 ALDKLSDSLGQRQPDPDENKPMEDKV---------KEKAKAEHRDKLGERDDTIPPEYRH 684
+ +LS + P EN P E V K + +DK ERD PE
Sbjct: 876 STPELS---AEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTT 932
Query: 685 LLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAA 744
K T+K+ +SK A + T+ T+Q+T K
Sbjct: 933 AAPK--MTKETATTTEKTTESKITA-------------TTTQVTSTTTQDTTPFKITTLK 977
Query: 745 SSSKAPKNGGKAKDSAKT-----TEETSKPKD 771
+++ APK K T EET+KPKD
Sbjct: 978 TTTLAPKVTTTKKTITTTEIMNKPEETAKPKD 1009
Score = 47.0 bits (110), Expect = 7e-05
Identities = 121/610 (19%), Positives = 200/610 (32%), Gaps = 92/610 (15%)
Query: 7 KPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTA 66
K A P+ A + +P+ P E + KK + + T A
Sbjct: 582 KEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 641
Query: 67 SATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTK 126
T + + + P E P + + P+ P K+ T P++ + +T
Sbjct: 642 PTTPEELAPTTPEEPTPTTPEEPA--PTTPKAAAPNTP------KEPAPTTPKEPAPTTP 693
Query: 127 PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISG 186
+ P +T K + + ++P+ +T K P+++ + T
Sbjct: 694 KEPAPTTPKETAPT---TPKGTAPTTLKEPAP-TTPKKPAPKELAPTTTKEPTSTTCDKP 749
Query: 187 KP----GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 242
P G K P P E P P G + + T P E TT
Sbjct: 750 APTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPKKPAPKELAPTTTK 808
Query: 243 GPE--VSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS 300
GP SD + T +E T P + KK T P P +S
Sbjct: 809 GPTSTTSDKPAPTTPKETAP---TTPKEPAPTTPKKPAPTTPET-------PPPTTSEVS 858
Query: 301 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP-----PQEKKRKVEKDTMSDQAL 355
+ T PT K + EST L A+ +P P K K M+ A
Sbjct: 859 TPTTTKEPTTIHKSPD--ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAK 916
Query: 356 EALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEY-----RLKPATD 410
+ + E DLR+ E A K K E ++T S+ ++ T
Sbjct: 917 DKTT----------ERDLRTTPETTTAAPKMTK-ETATTTEKTTESKITATTTQVTSTTT 965
Query: 411 KDGKP----------LLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESK 460
+D P L P+ K + +E++++ E+ +KP ++ SK
Sbjct: 966 QDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK----------PEETAKPKDRATNSK 1015
Query: 461 AAAPAPVSEAVCRTSMCSIQ-----------SAPPEPATLKGTVPD-DAVEALADSLGKK 508
A P P S + P P + T+P+ + +A+++ +
Sbjct: 1016 ATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQT 1075
Query: 509 EADPEDGKPVMDKVKEKAKEEDREKLGEKEET-----IPPDYRLEEVKDKDGKPLLPKES 563
P P V+ K ED G + ET P + E D D P +P +
Sbjct: 1076 TTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQG 1132
Query: 564 KEQLPPMSED 573
P +S++
Sbjct: 1133 IIINPMLSDE 1142
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 64.3 bits (155), Expect = 4e-10
Identities = 108/745 (14%), Positives = 238/745 (31%), Gaps = 30/745 (4%)
Query: 28 SEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPT 87
S +S+S S + S SS SS + + S+ S SS + SKS S +
Sbjct: 587 SSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSN 646
Query: 88 ETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKA 147
+ + S + + N + ++ S S+ S +SD+ ++ + +
Sbjct: 647 SSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSN-SSDSSDSSDSSNSSESSDSS 705
Query: 148 VSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESK 207
S ++ S S+ + D ++ S + ++ S D S +S
Sbjct: 706 DSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSS------DSS 759
Query: 208 PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPP 267
S S + D D+ + + N++ + + SS + + +
Sbjct: 760 DSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSS--- 816
Query: 268 KYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQ 327
+ + + +DSS D+ D SSD + GS + + +++ S++ +
Sbjct: 817 ---DSDSSNSSDSSNSSDSSDSSNSSDSSD--SSDSSDGSDSDSSNRSDSSNSSDSSDSS 871
Query: 328 SAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEE 387
+ ++ + SD + + S S + + D + + E+ +
Sbjct: 872 DSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSD 931
Query: 388 KLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKE 447
+ + ++D + + S+ D S D S
Sbjct: 932 NSNSSDSSNSS--------DSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSS 983
Query: 448 KPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGK 507
S ++ ++ S ++ + S++ + ++ + + D+ ++ S
Sbjct: 984 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSS 1043
Query: 508 KEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQL 567
+D D + + + + + D E D S
Sbjct: 1044 DSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDS--SESSDSSDSSNSSDSSDSSD 1101
Query: 568 PPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQS 627
S D + S D S N+S ++ S S + S+ + + S
Sbjct: 1102 SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSD 1161
Query: 628 DKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLD 687
D D+ D S D ++ D ++ D D + +
Sbjct: 1162 SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD-----S 1216
Query: 688 DNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSS 747
+ D + S +S +D D D+ + S S + S + + D+ + S
Sbjct: 1217 SDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSG 1276
Query: 748 KAPKNGGKAKDSAKTTEETSKPKDD 772
NG + ++ ++ DD
Sbjct: 1277 NGNNNGSDSDSDSEGSDSNHSTSDD 1301
Score = 61.2 bits (147), Expect = 3e-09
Identities = 110/760 (14%), Positives = 246/760 (32%), Gaps = 40/760 (5%)
Query: 28 SEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPT 87
++ +S S G+ SD + S SS SS + ++ + S S + S SS + +
Sbjct: 534 NDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDS 593
Query: 88 ETK-------AIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSN 140
++ + S + + K + K+E + +K S +SD+ N
Sbjct: 594 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDN 653
Query: 141 DAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTP 200
+ + S ++ + + D ++ S + ++ S + D S +
Sbjct: 654 SDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSS 713
Query: 201 AVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGK 260
S + S + D ++ + ++ N++ + SD +S+ +
Sbjct: 714 DSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSS-DSSDSSDSSNSSDSSDSSD 772
Query: 261 REVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDAL-SSDFTCGSPTAAGKKTEKEE 319
+ + +DS+ D+ D+ SSD + S ++ + +
Sbjct: 773 -------------SSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSD 819
Query: 320 STEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEV 379
S+ + ++ ++ + + SD S S + + D + +
Sbjct: 820 SSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDS 879
Query: 380 DEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 439
++ E D + ++D D + S S D
Sbjct: 880 SDSSDSNESSNSSDSSDSS--------NSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSD 931
Query: 440 FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPD--DA 497
S S ++ ++ S ++ + S++ + S+ ++ D D+
Sbjct: 932 NSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDS 991
Query: 498 VEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKP 557
++ S +D D D + + + D + D
Sbjct: 992 SDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSD-SSDSSDSSDSSD 1050
Query: 558 LLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQA 617
+ S+ S+ ++ S D+ ++ S+ + +S +
Sbjct: 1051 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSD 1110
Query: 618 GAPPRDTSQS--DKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERD 675
+ D+S S D D+ D S D ++ D ++ D D
Sbjct: 1111 SSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSD 1170
Query: 676 DTIPPEYRHLLD-DNGQDKPVKPPTKKSEDSKKPADDQDPIDA--LSGDLDSCPSTTETS 732
+ + + D + D + S DS +D D D+ S DS S+ +
Sbjct: 1171 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1230
Query: 733 QNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 772
N + D + SS + N + DS+ +++ TS D+
Sbjct: 1231 SNESSDSSDSSDSSDSS--NSSDSSDSSDSSDSTSDSNDE 1268
Score = 33.5 bits (75), Expect = 0.77
Identities = 32/146 (21%), Positives = 55/146 (37%), Gaps = 11/146 (7%)
Query: 623 DTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY 682
D S + D + D S S G + DE+K + K E DD+
Sbjct: 469 DESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKG--------AEDDDSDSTSD 520
Query: 683 RHLLDDNGQDKPVKPPTKKSEDSKKPAD--DQDPIDALSGDLDSCPSTTETSQNTAKDKC 740
+ D NG KS+ K +D D D D+ S DS S+ S ++
Sbjct: 521 TNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDS-SNSSDSSDSSDSDSSDSNSSSD 579
Query: 741 KKAASSSKAPKNGGKAKDSAKTTEET 766
++ S + + + DS+ +++ +
Sbjct: 580 SDSSDSDSSDSSDSDSSDSSNSSDSS 605
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 63.5 bits (153), Expect = 7e-10
Identities = 89/430 (20%), Positives = 168/430 (39%), Gaps = 28/430 (6%)
Query: 10 ASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASAT 69
A P+P RAA + S +S S S + ++ A + + A A
Sbjct: 198 APPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAA 257
Query: 70 KVSASSGATSKSSSMNPTETKAIPVSQQMEGPHL---PNKKKHKKQAVKTEPEKKS-QST 125
++S+ SS + E + P+ + GP+ P K+++ T+P KK+ +
Sbjct: 258 TTPTRKSSSSEDSSSDEEEEQKKPMKNK-PGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQ 316
Query: 126 KPKSLPKQASDTGSNDAHNKK------AVSR-SAEQQPSEKSTEPKTKPQDMISAGGESV 178
+P + +SD + + +K VS+ + + P++K+ E + D S+ +
Sbjct: 317 QPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEA 376
Query: 179 AGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEEN 238
A + K K + +PAV + P +P G L+ +EEE+
Sbjct: 377 PSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGG------QKLLTRKADSSSSEEES 430
Query: 239 TTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDA 298
++ + +++T + K +++P K +G +DS ++ +
Sbjct: 431 SSSEEEKTKKMVATTKPKATAKAALSLPAK-----QAPQGSRDSSSDSDSSSSEEEE-EK 484
Query: 299 LSSDFTCGSP--TAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE-KDTMSDQAL 355
S P A G K S + KA+S+ + S +E++ K++ K + QA
Sbjct: 485 TSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAP 544
Query: 356 EALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKP 415
+A S T Q + S +E +E K + K G + +E + T + K
Sbjct: 545 KANGTSALTAQ-NGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKI 603
Query: 416 LLPEPEEKPK 425
L P PK
Sbjct: 604 KLQTPNTFPK 613
Score = 59.7 bits (143), Expect = 1e-08
Identities = 132/647 (20%), Positives = 229/647 (35%), Gaps = 153/647 (23%)
Query: 68 ATKVSASSGATSKSSSMNPTET------KAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKK 121
A K + ++GAT + ++ + K+ V ++ + P KK KK+A ++ E
Sbjct: 31 ANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKASSSDSEDS 90
Query: 122 SQSTK--------------------PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKST 161
S+ + P +AS++ S++ + ++QP +K
Sbjct: 91 SEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGV 150
Query: 162 EPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPA-VPVESK-PDKPSGKS---- 215
+P+ K +S + S + K +K +TP V ++K P KP+ +
Sbjct: 151 KPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIA 210
Query: 216 -GMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLA 274
G A+ + +++EEE T + T+P K +++A
Sbjct: 211 NGKAASSSSSSSSSSSSDDSEEEKAAATPKK------------------TVPKK--QVVA 250
Query: 275 KKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRS 334
K P ++ P + + SSD E+EE + +K G S
Sbjct: 251 K-----APVKAATTPTRKSSSSEDSSSD-------------EEEEQKKPMK-NKPGPYSS 291
Query: 335 AAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGE 394
PP K SLGT+ + K V++ + E + E
Sbjct: 292 VPPPSAPPPK---------------KSLGTQPPK--------KAVEKQQPVESSEDSSDE 328
Query: 395 DDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTE 454
D + SE KP T K ++ + KP P ++ S D D SE E PSKP
Sbjct: 329 SDSS--SEEEKKPPT----KAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAG 382
Query: 455 KTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPED 514
T+ S + PA +++ PA P V
Sbjct: 383 TTKNS-SNKPAVTTKS---------------PAVKPAAAPKQPVGG-------------- 412
Query: 515 GKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDF 574
G+ ++ + + + E+ E+E+T + K K +Q P S D
Sbjct: 413 GQKLLTRKADSSSSEEESSSSEEEKT---KKMVATTKPKATAKAALSLPAKQAPQGSRDS 469
Query: 575 LLD---ALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDL 631
D + SE+ + S++K + K+A PAS + A ++S SD
Sbjct: 470 SSDSDSSSSEEEEEKTSKSAVKKKPQKVAGG---AAPSKPASAKKGKAESSNSSSSDDSS 526
Query: 632 DDALDKLSDSLGQRQPDPDEN-------------KPMEDKVKEKAKA 665
++ +KL R P N K E++ +EK KA
Sbjct: 527 EEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKA 573
Score = 57.0 bits (136), Expect = 6e-08
Identities = 119/542 (21%), Positives = 199/542 (36%), Gaps = 81/542 (14%)
Query: 4 PGQKPAASPR-----PRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSS 58
P K AA P P AAA+ + SE++S+ + +KK +K
Sbjct: 100 PPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGV--------- 150
Query: 59 RTYAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEP 118
+ A + K + SS + S SSS + P +K K V +
Sbjct: 151 KPQAKAAKAPPKKAKSSDSDSDSSSEDEP----------------PKNQKPKITPVTVKA 194
Query: 119 EKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEP-KTKPQDMISAGGES 177
+ K+ ++ PK A+ ++ + + + S S + + + + P KT P+ + A
Sbjct: 195 QTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPV 254
Query: 178 VAGIT------AISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGP 231
A T + D+++E+K P+++KP S A P
Sbjct: 255 KAATTPTRKSSSSEDSSSDEEEEQKK-----PMKNKPGPYSSVPPPSAPPPKKSLGTQPP 309
Query: 232 EETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIG 291
++ E+ E S S + EE K P + +++K T PP
Sbjct: 310 KKAVEKQQPVESSEDSSDESDSSSEEEKK------PPTKAVVSK--ATTKPPPAKKAAES 361
Query: 292 PDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMS 351
D+ D+ SS+ AG T K S + + V+ AA P++ +K
Sbjct: 362 SSDSSDSDSSEDDEAPSKPAG--TTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQK---- 415
Query: 352 DQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDK 411
L TR+A+ S E + + ++EEK +K T + K A
Sbjct: 416 ----------LLTRKAD-----SSSSEEESSSSEEEKTKKM---VATTKPKATAKAALSL 457
Query: 412 DGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAV 471
K P+ S+S +E E +S K+KP K SK A+ A +A
Sbjct: 458 PAKQ-APQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPAS-AKKGKAE 515
Query: 472 CRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 531
S S S+ E LKG A+ G ++GK + +E EE++
Sbjct: 516 SSNSSSSDDSSEEEEEKLKGKGSPRPQAPKAN--GTSALTAQNGKAAKNSEEE---EEEK 570
Query: 532 EK 533
+K
Sbjct: 571 KK 572
Score = 55.8 bits (133), Expect = 1e-07
Identities = 84/379 (22%), Positives = 139/379 (36%), Gaps = 67/379 (17%)
Query: 442 RSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEAL 501
+++ K S + +EE + P +A + PP A K + + E+
Sbjct: 77 KAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGL---PPGKAAAKASESSSSEESS 133
Query: 502 ADSLGKKEADPEDGK--PVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 559
D D ED K PV VK +AK K D E+ K+ KP +
Sbjct: 134 DDD------DEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKI 187
Query: 560 -----------PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVS 608
P + P ++ A S S ++SS E+ K AA + V
Sbjct: 188 TPVTVKAQTKAPPKPARAAPKIANG---KAASSSSSSSSSSSSDDSEEEKAAATPKKTVP 244
Query: 609 Q----TPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQ-----------PDPDEN- 652
+ A A P R +S S+ D ++ + + P P ++
Sbjct: 245 KKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSL 304
Query: 653 --KPMEDKVKEKAKAEHRDKLGERDDTIPPEYRH----LLDDNGQDKPVKPPTKKSEDSK 706
+P + V+++ E + + D+ E + + KP PP KK+ +S
Sbjct: 305 GTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKP--PPAKKAAESS 362
Query: 707 KPADDQDPIDALSGDLDSCPS----TTETSQN----TAKDKCKKAASSSKAPKNGG---- 754
+ D D S + D PS TT+ S N T K K A++ K P GG
Sbjct: 363 SDSSDSD-----SSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLL 417
Query: 755 -KAKDSAKTTEETSKPKDD 772
+ DS+ + EE+S +++
Sbjct: 418 TRKADSSSSEEESSSSEEE 436
Score = 54.7 bits (130), Expect = 3e-07
Identities = 120/547 (21%), Positives = 192/547 (35%), Gaps = 76/547 (13%)
Query: 3 QPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYA 62
Q G KP A A+ + + + P K + K + A + A
Sbjct: 147 QKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAA 206
Query: 63 GGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKS 122
A+ S+SS ++S SSS + E KA P K KKQ V P K
Sbjct: 207 PKIANGKAASSSSSSSSSSSSDDSEEEKAAAT---------PKKTVPKKQVVAKAPVK-- 255
Query: 123 QSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSE-KSTEPKTKPQDMISAGGESVAGI 181
+T P + D+ S++ +K + + +P S P + P S G +
Sbjct: 256 AATTPTRKSSSSEDSSSDEEEEQK---KPMKNKPGPYSSVPPPSAPPPKKSLGTQ----- 307
Query: 182 TAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTY 241
P K EK+ PVES D D D+ E+
Sbjct: 308 ------PPKKAVEKQQ-----PVESSEDS-----------SDESDSSSEEEKKPPTKAVV 345
Query: 242 TGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSS 301
+ P + E + + E +K G T S+KP A+++
Sbjct: 346 SKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTT--KNSSNKP--------AVTT 395
Query: 302 DFTCGSPTAAGKK-TEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA 360
P AA K+ + KA S+ + ++ +E+K K T +A +
Sbjct: 396 KSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAAL 455
Query: 361 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDG-KPLLPE 419
SL +QA P+ S + D + ++E E+++T S + KP G P P
Sbjct: 456 SLPAKQA-PQGSRDSSSDSDSSSSEE-------EEEKTSKSAVKKKPQKVAGGAAPSKPA 507
Query: 420 PEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSI 479
+K K S + S+D E ++ K + + + KA S + +
Sbjct: 508 SAKKGKAESSN---SSSSDDSSEEEEEKLKGKGSPRPQAPKANG---TSALTAQNGKAAK 561
Query: 480 QSAPPEPATLKGTVPDDAVEALADSLGKK---EADPEDGKPVMDKVK-EKAKEEDREKLG 535
S E K V V + + SL K+ EA E P K+K + + K G
Sbjct: 562 NSEEEEEEKKKAAV----VVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKG 617
Query: 536 EKEETIP 542
EK + P
Sbjct: 618 EKRASSP 624
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 63.2 bits (152), Expect = 9e-10
Identities = 167/831 (20%), Positives = 309/831 (37%), Gaps = 97/831 (11%)
Query: 4 PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAAS---LGSSQSSRT 60
PG+ +P + A A +T E+ SES S+ E S+E+ A+ L + S +T
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSE--ESSDSEEETPAAKALLQAKASGKT 368
Query: 61 YAGGTASA-TKVSASSGAT-SKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQA-VKTE 117
G ASA K S GA + P KA ++ + + +++A + +
Sbjct: 369 SQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAK 428
Query: 118 PEKKSQSTKPKSLP-KQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGE 176
P K+ + S P K++ G+ A +K +A+ Q ++ + ++ ++ + E
Sbjct: 429 PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES-DSDRE 487
Query: 177 SVAGITAISGKPGDKKKEKKSLTPAVPVESKP------DKPSGKSGMDAALDDLIDTLGG 230
++A + A KP K + K PA + P P GK G +
Sbjct: 488 ALAAMNAAQVKPLGKSPQVK---PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEED 544
Query: 231 PEETEEENTTYTGPEVSDPMSSTYIEELGK----REVTIPPKYRELLAKKEGITGPPADS 286
E + EE++ + EV ++ + LG + + P K +K G +
Sbjct: 545 SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGP---PQKAGPVAVQVKA 601
Query: 287 SKPI----GPDDAIDALSSDFTCGSPTAA-GKKTEKEESTEVLKAQSAGTVRSAAPPQEK 341
KP+ +++ D+ S+ + TAA K K T+ ++ T + P
Sbjct: 602 EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRV 661
Query: 342 KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE------EKLEKCGED 395
+ + + + S ++ P D S +E D + K + + G+
Sbjct: 662 GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKG 721
Query: 396 DETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK 455
+ + +K + + P+LP K P + +++ E ED + SE E
Sbjct: 722 LQVKAASVPVKGSLGQGTAPVLP---GKTGP-TVTQVKAEKQEDSESSE--------EES 769
Query: 456 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTV--PDDAVEALADSLGKKEAD-- 511
E AA+PA V +V +T + +A P+ KGT+ P V A A + + +
Sbjct: 770 DSEEAAASPAQVKTSVKKTQAKANPAAARAPSA-KGTISAPGKVVTAAAQAKQRSPSKVK 828
Query: 512 -------------------PEDGKPVMDKVK-EKAKEEDREKLGEKEETIPPDYRLEEVK 551
P GK V + + EED E+ ++ L +VK
Sbjct: 829 PPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVK 888
Query: 552 DKDGKPLLPKESKEQLPPMSEDFLLDA--LSEDFSGPQNASSLKFEDAKLAAAISEVVSQ 609
GK + + L P E A +GP A + K +D+ ++ S+ +
Sbjct: 889 -PSGK---THQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGE 944
Query: 610 TPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 669
PA+ T A D + A + + Q P + + E + + +
Sbjct: 945 APAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDE 1004
Query: 670 KLGERDDTIPPEYRHLLDDNGQDKPVKPP------------TKKSEDSKKPADDQDPIDA 717
+ + P R + P P + + D KK +D+
Sbjct: 1005 DVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDS 1064
Query: 718 LSGDL--DSCPSTTETSQNT---AKDKCKKAASSSKAPKNGGKAKDSAKTT 763
G L S ST+ ++ T K K + ++KAP++ ++DS+ ++
Sbjct: 1065 AVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSS 1115
Score = 59.3 bits (142), Expect = 1e-08
Identities = 160/784 (20%), Positives = 268/784 (34%), Gaps = 121/784 (15%)
Query: 35 PSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAIPV 94
P+ P + G E+ + S SS+ S + G +V + + S N + K P
Sbjct: 531 PATPSAQVGKWEEDSES--SSEESSDSSDG-----EVPTAVAPAQEKSLGNILQAK--PT 581
Query: 95 SQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQ 154
S +GP +K AV+ + EK +++ +++SD S D+ A +A+
Sbjct: 582 SSPAKGP----PQKAGPVAVQVKAEKPMDNSESS---EESSD--SADSEEAPAAMTAAQA 632
Query: 155 QPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGK 214
+P+ K + K P+ + VA + + P +K+ T P S P G
Sbjct: 633 KPALKIPQTKACPKKTNTTASAKVAPVRVGTQAP------RKAGTATSPAGSSPAVAGGT 686
Query: 215 SGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPK------ 268
D+ E EE T G V+ + + + L + ++P K
Sbjct: 687 QRPAE------DSSSSEESDSEEEKT--GLAVTVGQAKSVGKGLQVKAASVPVKGSLGQG 738
Query: 269 YRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPT---AAGKKTEKEESTEVLK 325
+L K G T + K + + + S+ SP + KKT+ + + +
Sbjct: 739 TAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAAR 798
Query: 326 AQSA-GTVRS-----AAPPQEKKR---KVEKDTMSDQALEALS-------------ASLG 363
A SA GT+ + A Q K+R KV+ + Q L+ A+
Sbjct: 799 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 858
Query: 364 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 423
Q PE D S +E +++ + E L + +T L PA + K P P K
Sbjct: 859 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 918
Query: 424 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 483
P + K+ S + + +S APA V+ A Q
Sbjct: 919 TGPSAAQA-------------GKQDDSGSSSEESDSDGEAPAAVTSA---------QVIK 956
Query: 484 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 543
P P A A + + + P + + + E + E + + + P
Sbjct: 957 P-PLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTP 1015
Query: 544 DYRLEEVKDKDGKP-LLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAA 602
R V P + PK S E +S+ A+ + L A
Sbjct: 1016 GIRTNVVTMPTAHPRIAPKASMAGASSSKES---SRISDGKKQEGPATQVDSAVGTLPAT 1072
Query: 603 ISEVVSQTPASTTQAGAPP----RDTSQSDKDLDDALDKLSDSLGQRQPD--PDENKPME 656
+ S T + P + +++ + DD+ D S G + P K
Sbjct: 1073 SPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAH 1132
Query: 657 DKV-----KEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADD 711
V + + E DD + P L +G P P P
Sbjct: 1133 TLVGPTPSRTETLVEETAAESSEDDVVAPSQSLL---SGYMTPGLTPANSQASKATPK-- 1187
Query: 712 QDPIDALSGDLDSCPSTTET----SQNTAKDKCK-KAASSSKAPKNGGKAKDSAKTTEET 766
LDS PS + T K + K + A+ +PK GGK S T +++
Sbjct: 1188 ----------LDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKS 1237
Query: 767 SKPK 770
KPK
Sbjct: 1238 RKPK 1241
Score = 53.5 bits (127), Expect = 7e-07
Identities = 143/683 (20%), Positives = 226/683 (33%), Gaps = 108/683 (15%)
Query: 154 QQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSG 213
QQ SE + K + + A V+ + S + E++ A ++ P S
Sbjct: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTS-----ESSEEEEEAEAETAKATPRLAST 108
Query: 214 KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEEL--GK--REVTIPPKY 269
S + A DL ++ + E E TG + P + + L GK R+ P
Sbjct: 109 NSSVLGA--DLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSAN 166
Query: 270 RELLAKKEGITGPPA--DSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQ 327
L+++ E PA ++KP + A +D + +++ +T+ E V AQ
Sbjct: 167 TTLVSETEEEGSVPAFGAAAKP----GMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQ 222
Query: 328 SAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL--GTRQAEPELDLRSIKEVDEAKAK 385
+ S +K + D + +L R +PE + S +E E+
Sbjct: 223 VKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSES--- 279
Query: 386 EEKLEKCGEDDETIPSEYRLK------PATDKDGKPLLPEPEEKPKPRSESELIDELSED 439
E+ G + SE L+ PA GK P P K + + ED
Sbjct: 280 -EEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEED 338
Query: 440 FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 499
+ S E+ S E+T +KA A S +TS SAP + + KG P
Sbjct: 339 SESSS--EESSDSEEETPAAKALLQAKASG---KTSQVGAASAPAKESPRKGAAP----- 388
Query: 500 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEK---EETIP---------PDYRL 547
A P P + K + +EED + E+ EE P P R
Sbjct: 389 ----------APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438
Query: 548 EEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVV 607
K+ P++ PP + + SS + D+ A +
Sbjct: 439 ASAPAKES----PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNA 494
Query: 608 SQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEH 667
+Q P T A +G P K ED E + E
Sbjct: 495 AQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEED--SESSSEES 552
Query: 668 RDKL-GERDDTIPPEYRHLLDDNGQDKPVKPPTK-----------------------KSE 703
D GE + P L + Q KP P K SE
Sbjct: 553 SDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSE 612
Query: 704 DSKKPADDQDPIDALSG----------DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNG 753
+S AD ++ A++ +CP T T TA K ++AP+
Sbjct: 613 ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNT---TASAKVAPVRVGTQAPRKA 669
Query: 754 GKAKDSAKTTEE----TSKPKDD 772
G A A ++ T +P +D
Sbjct: 670 GTATSPAGSSPAVAGGTQRPAED 692
Score = 46.2 bits (108), Expect = 1e-04
Identities = 159/838 (18%), Positives = 294/838 (35%), Gaps = 86/838 (10%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
M+ KPA P+ A ++T+ S K + P + G + + K + + SS
Sbjct: 627 MTAAQAKPALKI-PQTKACPKKTNTTASAKVA--PVRVGTQ--APRKAGTATSPAGSSPA 681
Query: 61 YAGGTASATKVSASSGATSKSS-----SMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVK 115
AGGT + S+SS + ++ + K++ Q++ +P K +
Sbjct: 682 VAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAP 741
Query: 116 TEPEKKSQS-TKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAG 174
P K + T+ K+ ++ S++ ++ +++A + A+ + S K T+ K P +A
Sbjct: 742 VLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA---AAR 798
Query: 175 GESVAGITAISGKPGDKKKEKKSLTPAV---PVESKPDK------PSGKSGMDAALDDLI 225
S G + GK + K +P+ PV + + P+ + A+
Sbjct: 799 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 858
Query: 226 DTLGGPEE----TEEENTTYTGPEVS---DPMSSTYI---------EELGKREVTIPPKY 269
GPEE +EEE+ + E P T+ E K PP
Sbjct: 859 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 918
Query: 270 RELLAKKEGITGPPADSSKPIGPD-DAIDALSSDFTCGSPT--AAGKKTEKEESTEVLKA 326
A + G SS+ D +A A++S P ++ + +A
Sbjct: 919 TGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQA 978
Query: 327 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEA---LSASLGTR-----QAEPELDLR---- 374
Q+A T R A + R ++ + + A L+ + T A P + +
Sbjct: 979 QAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMA 1038
Query: 375 ---SIKE---VDEAKAKEEKLEKCGEDDETIPSEYRLKPA-----TDKDGKPLLPEPEEK 423
S KE + + K +E + T+P+ + T+K KP LPE ++
Sbjct: 1039 GASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA 1098
Query: 424 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQS-- 481
K S+ ++ S+ SE + + + P+ V T+ S +
Sbjct: 1099 TKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDV 1158
Query: 482 APPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET- 540
P + L G + A +S K D P + + D ++ + ++
Sbjct: 1159 VAPSQSLLSGYMTPGLTPA--NSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAA 1216
Query: 541 --IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDA-LSEDFSG---PQNASSLKF 594
+ P +E K K P + L + +++ G P N + ++
Sbjct: 1217 GMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQA 1276
Query: 595 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDA------LDKLSDSLGQRQPD 648
K+ + E + TT+ + S+ K D K LG +
Sbjct: 1277 SVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGG 1336
Query: 649 PDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKP 708
P + K KA+ RDK D + + L G + +K + +
Sbjct: 1337 EASVSPEKTSTTSKGKAK-RDKAS--GDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEG 1393
Query: 709 ADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEET 766
D +P + S + + K K KKA++ + K K KT E+T
Sbjct: 1394 GDQSNP-KSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQT 1450
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 63.2 bits (152), Expect = 9e-10
Identities = 167/831 (20%), Positives = 309/831 (37%), Gaps = 97/831 (11%)
Query: 4 PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAAS---LGSSQSSRT 60
PG+ +P + A A +T E+ SES S+ E S+E+ A+ L + S +T
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSE--ESSDSEEETPAAKALLQAKASGKT 368
Query: 61 YAGGTASA-TKVSASSGAT-SKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQA-VKTE 117
G ASA K S GA + P KA ++ + + +++A + +
Sbjct: 369 SQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAK 428
Query: 118 PEKKSQSTKPKSLP-KQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGE 176
P K+ + S P K++ G+ A +K +A+ Q ++ + ++ ++ + E
Sbjct: 429 PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES-DSDRE 487
Query: 177 SVAGITAISGKPGDKKKEKKSLTPAVPVESKP------DKPSGKSGMDAALDDLIDTLGG 230
++A + A KP K + K PA + P P GK G +
Sbjct: 488 ALAAMNAAQVKPLGKSPQVK---PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEED 544
Query: 231 PEETEEENTTYTGPEVSDPMSSTYIEELGK----REVTIPPKYRELLAKKEGITGPPADS 286
E + EE++ + EV ++ + LG + + P K +K G +
Sbjct: 545 SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGP---PQKAGPVAVQVKA 601
Query: 287 SKPI----GPDDAIDALSSDFTCGSPTAA-GKKTEKEESTEVLKAQSAGTVRSAAPPQEK 341
KP+ +++ D+ S+ + TAA K K T+ ++ T + P
Sbjct: 602 EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRV 661
Query: 342 KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE------EKLEKCGED 395
+ + + + S ++ P D S +E D + K + + G+
Sbjct: 662 GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKG 721
Query: 396 DETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK 455
+ + +K + + P+LP K P + +++ E ED + SE E
Sbjct: 722 LQVKAASVPVKGSLGQGTAPVLP---GKTGP-TVTQVKAEKQEDSESSE--------EES 769
Query: 456 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTV--PDDAVEALADSLGKKEAD-- 511
E AA+PA V +V +T + +A P+ KGT+ P V A A + + +
Sbjct: 770 DSEEAAASPAQVKTSVKKTQAKANPAAARAPSA-KGTISAPGKVVTAAAQAKQRSPSKVK 828
Query: 512 -------------------PEDGKPVMDKVK-EKAKEEDREKLGEKEETIPPDYRLEEVK 551
P GK V + + EED E+ ++ L +VK
Sbjct: 829 PPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVK 888
Query: 552 DKDGKPLLPKESKEQLPPMSEDFLLDA--LSEDFSGPQNASSLKFEDAKLAAAISEVVSQ 609
GK + + L P E A +GP A + K +D+ ++ S+ +
Sbjct: 889 -PSGK---THQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGE 944
Query: 610 TPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 669
PA+ T A D + A + + Q P + + E + + +
Sbjct: 945 APAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDE 1004
Query: 670 KLGERDDTIPPEYRHLLDDNGQDKPVKPP------------TKKSEDSKKPADDQDPIDA 717
+ + P R + P P + + D KK +D+
Sbjct: 1005 DVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDS 1064
Query: 718 LSGDL--DSCPSTTETSQNT---AKDKCKKAASSSKAPKNGGKAKDSAKTT 763
G L S ST+ ++ T K K + ++KAP++ ++DS+ ++
Sbjct: 1065 AVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSS 1115
Score = 59.3 bits (142), Expect = 1e-08
Identities = 162/791 (20%), Positives = 272/791 (34%), Gaps = 136/791 (17%)
Query: 35 PSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAIPV 94
P+ P + G E+ + S SS+ S + G +V + + S N + K P
Sbjct: 531 PATPSAQVGKWEEDSES--SSEESSDSSDG-----EVPTAVAPAQEKSLGNILQAK--PT 581
Query: 95 SQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQ 154
S +GP +K AV+ + EK +++ +++SD S D+ A +A+
Sbjct: 582 SSPAKGP----PQKAGPVAVQVKAEKPMDNSESS---EESSD--SADSEEAPAAMTAAQA 632
Query: 155 QPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGK 214
+P+ K + K P+ + VA + + P +K+ T P S P G
Sbjct: 633 KPALKIPQTKACPKKTNTTASAKVAPVRVGTQAP------RKAGTATSPAGSSPAVAGGT 686
Query: 215 SGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPK------ 268
D+ E EE T G V+ + + + L + ++P K
Sbjct: 687 QRPAE------DSSSSEESDSEEEKT--GLAVTVGQAKSVGKGLQVKAASVPVKGSLGQG 738
Query: 269 YRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPT---AAGKKTEKEESTEVLK 325
+L K G T + K + + + S+ SP + KKT+ + + +
Sbjct: 739 TAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAAR 798
Query: 326 AQSA-GTVRS-----AAPPQEKKR---KVEKDTMSDQALEALS-------------ASLG 363
A SA GT+ + A Q K+R KV+ + Q L+ A+
Sbjct: 799 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 858
Query: 364 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 423
Q PE D S +E +++ + E L + +T L PA + K P P K
Sbjct: 859 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 918
Query: 424 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 483
P + K+ S + + +S APA V+ A Q
Sbjct: 919 TGPSAAQA-------------GKQDDSGSSSEESDSDGEAPAAVTSA---------QVIK 956
Query: 484 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 543
P P A A + + + P + + + E + E + + + P
Sbjct: 957 P-PLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTP 1015
Query: 544 DYRLEEVKDKDGKP-LLPKES-----------------KEQLPPMSEDFLLDALSEDFSG 585
R V P + PK S K++ P D + L +
Sbjct: 1016 GIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPA--TS 1073
Query: 586 PQNASSLKFEDAKLAAA-ISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQ 644
PQ+ S KL + EV T A + + S S + D + + S
Sbjct: 1074 PQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHT 1133
Query: 645 RQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSED 704
P P + + ++ ++ DD + P L +G P P
Sbjct: 1134 LGPTPSRTETLVEETAAESS---------EDDVVAPSQSLL---SGYMTPGLTPANSQAS 1181
Query: 705 SKKPADDQDPIDALSGDLDSCPSTTET----SQNTAKDKCK-KAASSSKAPKNGGKAKDS 759
P LDS PS + T K + K + A+ +PK GGK S
Sbjct: 1182 KATPK------------LDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAAS 1229
Query: 760 AKTTEETSKPK 770
T +++ KPK
Sbjct: 1230 GTTPQKSRKPK 1240
Score = 53.5 bits (127), Expect = 7e-07
Identities = 143/683 (20%), Positives = 226/683 (33%), Gaps = 108/683 (15%)
Query: 154 QQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSG 213
QQ SE + K + + A V+ + S + E++ A ++ P S
Sbjct: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTS-----ESSEEEEEAEAETAKATPRLAST 108
Query: 214 KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEEL--GK--REVTIPPKY 269
S + A DL ++ + E E TG + P + + L GK R+ P
Sbjct: 109 NSSVLGA--DLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSAN 166
Query: 270 RELLAKKEGITGPPA--DSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQ 327
L+++ E PA ++KP + A +D + +++ +T+ E V AQ
Sbjct: 167 TTLVSETEEEGSVPAFGAAAKP----GMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQ 222
Query: 328 SAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL--GTRQAEPELDLRSIKEVDEAKAK 385
+ S +K + D + +L R +PE + S +E E+
Sbjct: 223 VKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSES--- 279
Query: 386 EEKLEKCGEDDETIPSEYRLK------PATDKDGKPLLPEPEEKPKPRSESELIDELSED 439
E+ G + SE L+ PA GK P P K + + ED
Sbjct: 280 -EEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEED 338
Query: 440 FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 499
+ S E+ S E+T +KA A S +TS SAP + + KG P
Sbjct: 339 SESSS--EESSDSEEETPAAKALLQAKASG---KTSQVGAASAPAKESPRKGAAP----- 388
Query: 500 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEK---EETIP---------PDYRL 547
A P P + K + +EED + E+ EE P P R
Sbjct: 389 ----------APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438
Query: 548 EEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVV 607
K+ P++ PP + + SS + D+ A +
Sbjct: 439 ASAPAKES----PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNA 494
Query: 608 SQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEH 667
+Q P T A +G P K ED E + E
Sbjct: 495 AQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEED--SESSSEES 552
Query: 668 RDKL-GERDDTIPPEYRHLLDDNGQDKPVKPPTK-----------------------KSE 703
D GE + P L + Q KP P K SE
Sbjct: 553 SDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSE 612
Query: 704 DSKKPADDQDPIDALSG----------DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNG 753
+S AD ++ A++ +CP T T TA K ++AP+
Sbjct: 613 ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNT---TASAKVAPVRVGTQAPRKA 669
Query: 754 GKAKDSAKTTEE----TSKPKDD 772
G A A ++ T +P +D
Sbjct: 670 GTATSPAGSSPAVAGGTQRPAED 692
Score = 48.9 bits (115), Expect = 2e-05
Identities = 161/842 (19%), Positives = 296/842 (35%), Gaps = 95/842 (11%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
M+ KPA P+ A ++T+ S K + P + G + + K + + SS
Sbjct: 627 MTAAQAKPALKI-PQTKACPKKTNTTASAKVA--PVRVGTQ--APRKAGTATSPAGSSPA 681
Query: 61 YAGGTASATKVSASSGATSKSS-----SMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVK 115
AGGT + S+SS + ++ + K++ Q++ +P K +
Sbjct: 682 VAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAP 741
Query: 116 TEPEKKSQS-TKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAG 174
P K + T+ K+ ++ S++ ++ +++A + A+ + S K T+ K P +A
Sbjct: 742 VLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA---AAR 798
Query: 175 GESVAGITAISGKPGDKKKEKKSLTPAV---PVESKPDK------PSGKSGMDAALDDLI 225
S G + GK + K +P+ PV + + P+ + A+
Sbjct: 799 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 858
Query: 226 DTLGGPEE----TEEENTTYTGPEVS---DPMSSTYI---------EELGKREVTIPPKY 269
GPEE +EEE+ + E P T+ E K PP
Sbjct: 859 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 918
Query: 270 RELLAKKEGITGPPADSSKPIGPD-DAIDALSSDFTCGSPT--AAGKKTEKEESTEVLKA 326
A + G SS+ D +A A++S P ++ + +A
Sbjct: 919 TGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQA 978
Query: 327 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEA---LSASLGTR-----QAEPELDLR---- 374
Q+A T R A + R ++ + + A L+ + T A P + +
Sbjct: 979 QAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMA 1038
Query: 375 ---SIKE---VDEAKAKEEKLEKCGEDDETIPSEYRLKPA-----TDKDGKPLLPEPEEK 423
S KE + + K +E + T+P+ + T+K KP LPE ++
Sbjct: 1039 GASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA 1098
Query: 424 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAP------VSEAVCRTSMC 477
K S D+ + D S E+ + + + + P P V E +S
Sbjct: 1099 TKAPESS---DDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSED 1155
Query: 478 SIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEK 537
+ + P + L G + A +S K D P + + D ++ +
Sbjct: 1156 DVVA--PSQSLLSGYMTPGLTPA--NSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKP 1211
Query: 538 EET---IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDA-LSEDFSG---PQNAS 590
++ + P +E K K P + L + +++ G P N +
Sbjct: 1212 QQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEA 1271
Query: 591 SLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDA------LDKLSDSLGQ 644
++ K+ + E + TT+ + S+ K D K LG
Sbjct: 1272 QVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGA 1331
Query: 645 RQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSED 704
+ P + K KA+ RDK D + + L G + +K
Sbjct: 1332 GEGGEASVSPEKTSTTSKGKAK-RDKAS--GDVKEKKGKGSLGSQGAKDEPEEELQKGMG 1388
Query: 705 SKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTE 764
+ + D +P + S + + K K KKA++ + K K KT E
Sbjct: 1389 TVEGGDQSNP-KSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAE 1447
Query: 765 ET 766
+T
Sbjct: 1448 QT 1449
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 61.6 bits (148), Expect = 3e-09
Identities = 135/611 (22%), Positives = 219/611 (35%), Gaps = 77/611 (12%)
Query: 4 PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAG 63
P Q A P P++ +A+ + T P +PG K S ++ ++ SQ
Sbjct: 481 PQQPGPAKPPPQQPGSAKPPSQQPGS-TKPPPQQPGPAKPSPQQPGSTKPPSQQ------ 533
Query: 64 GTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHL------PNKKKHKKQAV-KT 116
+ K SA + +K S+ T+ PVSQ G L P+ K+ Q + KT
Sbjct: 534 --PGSAKPSAQQPSPAKPSAQQSTK----PVSQTGSGKPLQPPTVSPSAKQPPSQGLPKT 587
Query: 117 EPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK----TKPQDMIS 172
+ + +P++A+ + + V P+ TE K Q +
Sbjct: 588 ICPLCNTTELLLHVPEKANFNTCTEC--QTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRA 645
Query: 173 AGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPE 232
GG+ + + P K K T + +S P DAA + P+
Sbjct: 646 LGGD----LAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPK 701
Query: 233 ETEE--ENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPI 290
+ + T G + + L K PPK E E P AD KP
Sbjct: 702 KPPPLVKQPTLHGSPSAKAKQPPEADSLSK---PAPPK--EPSVPSEQDKAPVAD-DKPK 755
Query: 291 GP---DDAIDALSSDFTCGSPTAAGKKTE---KEESTEVLKAQSAGTVRSAAPPQEKKRK 344
P D +SS P K + +E++T LK SA +S P EK
Sbjct: 756 QPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSP 815
Query: 345 VEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGE-----DDETI 399
+ + A ++ S P + + K+VD + KEE + + D + +
Sbjct: 816 FDSKAIPRPASDSKIIS----HPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPM 871
Query: 400 PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEE- 458
P P +P P++ PKP+ +S L+ K +P+ P E
Sbjct: 872 PKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRF-SLNLGSITDAPKSQPTTPQETVTGK 930
Query: 459 ----------------SKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPD--DAVEA 500
S A P P S++ M AP +P T +G A A
Sbjct: 931 LFGFGASIFSQASNLISTAGQPGPHSQSGPGAPM-KQAPAPSQPPTSQGPPKSTGQAPPA 989
Query: 501 LADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP 560
A S+ K+ E P +K++ KA++ K E E+ PP + + + K +LP
Sbjct: 990 PAKSIPVKK---ETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLP 1046
Query: 561 KESKEQLPPMS 571
+ ++ P S
Sbjct: 1047 TKLEKSPKPES 1057
Score = 50.4 bits (119), Expect = 6e-06
Identities = 100/499 (20%), Positives = 182/499 (36%), Gaps = 87/499 (17%)
Query: 37 KPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAI---- 92
+PG++K E + SSQ ++ G + + S + + S+ PT+ K I
Sbjct: 1333 EPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGL 1392
Query: 93 --PVSQQMEGPHLPN-----------------------KKKHKKQAVKTEPEKKSQSTKP 127
Q P P+ K + K Q + PE+ K
Sbjct: 1393 KKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKT 1452
Query: 128 KSLPKQASDTGSNDAHNKKAVSR-------SAEQQPSEKSTEPKTKPQDMISAGGE---S 177
+SL + T S + + R S + PS K + K++ D I+ E S
Sbjct: 1453 QSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDS 1512
Query: 178 VAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGK-SGMDAALDDLIDTLGGPEETEE 236
V + P ++K + S+ + E K + G D +I+ + +
Sbjct: 1513 VEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGS 1572
Query: 237 ENTTYTGPEVSDPMSSTYI----EELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGP 292
E+ + ++ + SST E GK ++T K+R L K T D+ +
Sbjct: 1573 EDDEFIRNQLKEISSSTESQKKEETKGKGKIT-AGKHRRLTRKSS--TSIDEDAGRRHSW 1629
Query: 293 DDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSD 352
D D + SP ++T+ +ES E++ G R + +E ++
Sbjct: 1630 HDEDDEAFDE----SPELKYRETKSQESEELVVTGGGGLRRF--------KTIELNSTIA 1677
Query: 353 QALEALSASLGTR---QAEPELDLRSIKEVDEAKAKEE-----------------KLEKC 392
A S+ T EPEL++ S+ + E +++ E +
Sbjct: 1678 DKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSL 1737
Query: 393 GEDDETIPSEYR-----LKPATDKDGKPLLP---EPEEKPKPRSESELIDELSEDFDRSE 444
ED ++ PS + + A + PLLP + E+ + R E EL+ E + + +
Sbjct: 1738 DEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQ 1797
Query: 445 CKEKPSKPTEKTEESKAAA 463
+ K S K ++ + A
Sbjct: 1798 QQRKSSSKKSKKDKDELRA 1816
Score = 50.1 bits (118), Expect = 8e-06
Identities = 151/766 (19%), Positives = 263/766 (34%), Gaps = 92/766 (12%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPG-----------------EKKG 43
+ P + P P P + A + HE ++ P++P + G
Sbjct: 298 LPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPG 357
Query: 44 SDEKKAASLGSSQSSRTYAGGTASAT-----KVSASSGATSKSSSMNPTETKAIPVSQQM 98
+ + A LG ++ G ++ K A K+ + P K P +QQ+
Sbjct: 358 TTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAK--PPTQQV 415
Query: 99 EGPHLPNKKKHKKQAVKTEPEKKS--QSTKPKSLPKQASDTGSNDAHNKKAVSRSAE--- 153
P ++ + K K+ Q P +P Q + G A ++
Sbjct: 416 GTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPG 475
Query: 154 --QQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKP 211
+ P ++ K PQ SA S S KP ++ +P P +KP
Sbjct: 476 PAKPPPQQPGPAKPPPQQPGSAKPPSQ---QPGSTKPPPQQPGPAKPSPQQPGSTKPPSQ 532
Query: 212 SGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRE 271
S +A + T+ + T +G + P S ++ + +P
Sbjct: 533 QPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQ--GLPKTICP 590
Query: 272 LLAKKEGITGPPAD--------------SSKPIGPDDAIDALSS--DFTCGSPTAAGKKT 315
L E + P S P+ + + C A G
Sbjct: 591 LCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDL 650
Query: 316 EKEESTEVLKAQSAGTVRSAA----PPQEKKRKVEKDTMSDQALEALSASLGTRQAEPEL 371
S+ K ++A ++A PQ ++ +KD Q LS + ++ P +
Sbjct: 651 APVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQ---DLSKAPEPKKPPPLV 707
Query: 372 DLRSIKEVDEAKAKE----EKLEKCGEDDE-TIPSEYRLKP-ATDKDGKPLLPEPEEKPK 425
++ AKAK+ + L K E ++PSE P A DK +P + +P
Sbjct: 708 KQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLV 767
Query: 426 PRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPE 485
S + ++ +S+ +EK + P + + + P E V A P
Sbjct: 768 SSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFD----SKAIPR 823
Query: 486 PATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDY 545
PA+ + ++S G+K+ DP K K + K + K K PP
Sbjct: 824 PASDSKIISHPGPS--SESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGP 881
Query: 546 RLEEVKDKDGKPLLPK-ESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF--EDAKLAAA 602
R + PK + + + ++ + DA + PQ + K A + +
Sbjct: 882 RPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQ 941
Query: 603 ISEVVSQT----PASTTQAGAPPRDT-SQSDKDLDDALDKLSDSLGQRQPDPDENKPMED 657
S ++S P S + GAP + + S K S GQ P P ++ P
Sbjct: 942 ASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPK---STGQAPPAPAKSIP--- 995
Query: 658 KVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSE 703
VK++ KA +KL + + P R + KP PP K S+
Sbjct: 996 -VKKETKAPAAEKLEPKAEQAPTVKR----TETEKKP--PPIKDSK 1034
Score = 49.7 bits (117), Expect = 1e-05
Identities = 149/726 (20%), Positives = 264/726 (36%), Gaps = 143/726 (19%)
Query: 56 QSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVK 115
Q+ R +G K+ + S PTE+ SQ+ P K ++Q VK
Sbjct: 1110 QTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESS----SQKTAVPPQVKLVKKQEQEVK 1165
Query: 116 TEPEKK-----SQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDM 170
TE EK ++ + +P + + + SA Q+ E K P++
Sbjct: 1166 TEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEE 1225
Query: 171 ISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTL-- 228
E + P DKK ++ T A P E K D KS + A + L +
Sbjct: 1226 KIRSEEKKPLLEEKKPTPEDKKLLPEAKTSA-PEEQKHDLL--KSQVQIAEEKLEGRVAP 1282
Query: 229 -----GGPEETEEEN----TTYTGPEVSDPMSSTYIEE-----LGKREVTIPPKYRELLA 274
G +T+ E T + P+ D + T E+ K + P K +
Sbjct: 1283 KTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEK---T 1339
Query: 275 KKEGITGPPADSSKPIGPDDAIDA-LSSDFTCGSPTAAGK-----KTEKEESTEVLKAQS 328
+KE + S +P P D SSD G ++ G+ T++++ + LK S
Sbjct: 1340 EKEDDKSDTSSSQQPKSPQGLSDTGYSSD---GISSSLGEIPSLIPTDEKDILKGLKKDS 1396
Query: 329 AGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSI-----KEVDEAK 383
S + P + K+E +S LEA +++L ++E + + K+ ++ +
Sbjct: 1397 FSQESSPSSPSDLA-KLESTVLS--ILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQ 1453
Query: 384 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 443
+ E LE ++E S+ K KD + +P ++ + +SE +D+++
Sbjct: 1454 SLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDH---KEKSEFVDDITTR---- 1506
Query: 444 ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD 503
+P + EES + +PV + RTS+ S S
Sbjct: 1507 ------REPYDSVEESSESENSPVPQRKRRTSVGSSSS---------------------- 1538
Query: 504 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES 563
++ K+ED + GE+E+ I +E D+D
Sbjct: 1539 --------------------DEYKQEDSQGSGEEEDFIRKQI-IEMSADEDAS------- 1570
Query: 564 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFE-DAKLAAAISEVVSQTPASTTQAGAPPR 622
++F+ + L E S ++ + + K+ A +++ +++ A R
Sbjct: 1571 ----GSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRR 1626
Query: 623 DTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY 682
S D+D D+A D+ S L R+ E+ E+ V R K E + TI +Y
Sbjct: 1627 H-SWHDED-DEAFDE-SPELKYRETKSQES---EELVVTGGGGLRRFKTIELNSTIADKY 1680
Query: 683 --------RHLLDDNGQDKPVKPPTKKSEDSKK-------------PADDQDPIDALSGD 721
L D + ++ T ED + P + +L D
Sbjct: 1681 SAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDED 1740
Query: 722 LDSCPS 727
DS PS
Sbjct: 1741 SDSSPS 1746
Score = 45.1 bits (105), Expect = 3e-04
Identities = 166/869 (19%), Positives = 273/869 (31%), Gaps = 159/869 (18%)
Query: 2 SQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGS----DEKKAASLGSSQS 57
S P ++ P P R A + ++ PG + + K L
Sbjct: 90 SHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHK 149
Query: 58 SRTYAGGTASATKVSASSGATSK---------SSSMNPTETKAIPVSQQMEG-------P 101
S G + +SA S +K S + TK V Q+ +G P
Sbjct: 150 SSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKP 209
Query: 102 HL---PNKKKHKKQAVKTEP------EKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSA 152
L P K K+Q +P K S +P+ + Q TG +
Sbjct: 210 PLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDH 269
Query: 153 EQQPSEK-STEPKTKPQDMISAGGESVAGITAISGKPGDKKK------------EKKSLT 199
+ P ++ ++ P+TK D++ GESV KP ++ EK
Sbjct: 270 AKLPLQRDASRPQTKQADIVR--GESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPG 327
Query: 200 PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSST-----Y 254
PA P P +PSG + A + P T + GP P T
Sbjct: 328 PAKP----PAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGP-AKPPAQQTGSEKPS 382
Query: 255 IEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAA--- 311
E+ G + + PP + A++ G PP P L S PT
Sbjct: 383 SEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQ 442
Query: 312 ----GKKTEKEESTEVLKAQSAGTVRS-------AAPPQEKKRKVEKDTMSDQALEALSA 360
GK ++ AQ G + A PP ++ + + + S
Sbjct: 443 QPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQ 502
Query: 361 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 420
G+ + P+ + + + + ++ G + KP+ + KP+
Sbjct: 503 QPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTG 562
Query: 421 EEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVC---RTS 475
KP P S+ ++ C P T E P + C +T+
Sbjct: 563 SGKPLQPPTVSPSAKQPPSQGLPKTIC------PLCNTTELLLHVPEKANFNTCTECQTT 616
Query: 476 MCSIQSAPPEP------------ATLKGTVPDD--------------AVEALADSLGKKE 509
+CS+ P P +K + D A ++ K
Sbjct: 617 VCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSS 676
Query: 510 ADPEDGKPVMDKVKEKAKEEDREKLGEKEETIP----------PDYRLEEVKDKDG--KP 557
P+ P K+ A ++D K E ++ P P + ++ + D KP
Sbjct: 677 PQPQQTSPK----KDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKP 732
Query: 558 LLPKE----SKEQLPPMSEDF-----LLDALSEDFSGPQNASSLKFEDAKLAAAISEVVS 608
PKE S++ P+++D ++ ++ S + +K+ + E
Sbjct: 733 APPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEE--K 790
Query: 609 QTPASTTQAGAP------------PRDTSQ-----SDKDLDDALDKLSDSLGQRQPDPDE 651
TP T + P P D+ SD + S+S GQ+Q DP +
Sbjct: 791 TTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQ 850
Query: 652 NKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADD 711
K K + K + K + PP R GQ P + S KP +
Sbjct: 851 KKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPR---PTAGQTVPT------PQQSPKPQEQ 901
Query: 712 QDPIDALSGDLDSCP-STTETSQNTAKDK 739
G + P S T Q T K
Sbjct: 902 SRRFSLNLGSITDAPKSQPTTPQETVTGK 930
Score = 31.6 bits (70), Expect = 2.9
Identities = 33/145 (22%), Positives = 60/145 (41%), Gaps = 19/145 (13%)
Query: 29 EKTSESPSKPGEKKGSDEKKAASL--GSSQSSRTYAGGTASATKVSASSGATSKSSSMNP 86
E ++SP +GS A+S G+S +S +S + S SS + K S
Sbjct: 1702 ESLTDSPEDRSRGEGSSSLHASSFTPGTSPTS------VSSLDEDSDSSPSHKKGESKQQ 1755
Query: 87 TETKAIPVSQQMEGPHLPN-KKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNK 145
+ + P GP LP + +++ ++ E E + K + + +Q + S K
Sbjct: 1756 RKARHRP-----HGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSS-----K 1805
Query: 146 KAVSRSAEQQPSEKSTEPKTKPQDM 170
K+ E + + PKT P ++
Sbjct: 1806 KSKKDKDELRAQRRRERPKTPPSNL 1830
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 61.6 bits (148), Expect = 3e-09
Identities = 135/611 (22%), Positives = 219/611 (35%), Gaps = 77/611 (12%)
Query: 4 PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAG 63
P Q A P P++ +A+ + T P +PG K S ++ ++ SQ
Sbjct: 481 PQQPGPAKPPPQQPGSAKPPSQQPGS-TKPPPQQPGPAKPSPQQPGSTKPPSQQ------ 533
Query: 64 GTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHL------PNKKKHKKQAV-KT 116
+ K SA + +K S+ T+ PVSQ G L P+ K+ Q + KT
Sbjct: 534 --PGSAKPSAQQPSPAKPSAQQSTK----PVSQTGSGKPLQPPTVSPSAKQPPSQGLPKT 587
Query: 117 EPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK----TKPQDMIS 172
+ + +P++A+ + + V P+ TE K Q +
Sbjct: 588 ICPLCNTTELLLHVPEKANFNTCTEC--QTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRA 645
Query: 173 AGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPE 232
GG+ + + P K K T + +S P DAA + P+
Sbjct: 646 LGGD----LAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPK 701
Query: 233 ETEE--ENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPI 290
+ + T G + + L K PPK E E P AD KP
Sbjct: 702 KPPPLVKQPTLHGSPSAKAKQPPEADSLSK---PAPPK--EPSVPSEQDKAPVAD-DKPK 755
Query: 291 GP---DDAIDALSSDFTCGSPTAAGKKTE---KEESTEVLKAQSAGTVRSAAPPQEKKRK 344
P D +SS P K + +E++T LK SA +S P EK
Sbjct: 756 QPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSP 815
Query: 345 VEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGE-----DDETI 399
+ + A ++ S P + + K+VD + KEE + + D + +
Sbjct: 816 FDSKAIPRPASDSKIIS----HPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPM 871
Query: 400 PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEE- 458
P P +P P++ PKP+ +S L+ K +P+ P E
Sbjct: 872 PKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRF-SLNLGSITDAPKSQPTTPQETVTGK 930
Query: 459 ----------------SKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPD--DAVEA 500
S A P P S++ M AP +P T +G A A
Sbjct: 931 LFGFGASIFSQASNLISTAGQPGPHSQSGPGAPM-KQAPAPSQPPTSQGPPKSTGQAPPA 989
Query: 501 LADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP 560
A S+ K+ E P +K++ KA++ K E E+ PP + + + K +LP
Sbjct: 990 PAKSIPVKK---ETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLP 1046
Query: 561 KESKEQLPPMS 571
+ ++ P S
Sbjct: 1047 TKLEKSPKPES 1057
Score = 50.4 bits (119), Expect = 6e-06
Identities = 100/499 (20%), Positives = 182/499 (36%), Gaps = 87/499 (17%)
Query: 37 KPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAI---- 92
+PG++K E + SSQ ++ G + + S + + S+ PT+ K I
Sbjct: 1333 EPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGL 1392
Query: 93 --PVSQQMEGPHLPN-----------------------KKKHKKQAVKTEPEKKSQSTKP 127
Q P P+ K + K Q + PE+ K
Sbjct: 1393 KKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKT 1452
Query: 128 KSLPKQASDTGSNDAHNKKAVSR-------SAEQQPSEKSTEPKTKPQDMISAGGE---S 177
+SL + T S + + R S + PS K + K++ D I+ E S
Sbjct: 1453 QSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDS 1512
Query: 178 VAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGK-SGMDAALDDLIDTLGGPEETEE 236
V + P ++K + S+ + E K + G D +I+ + +
Sbjct: 1513 VEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGS 1572
Query: 237 ENTTYTGPEVSDPMSSTYI----EELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGP 292
E+ + ++ + SST E GK ++T K+R L K T D+ +
Sbjct: 1573 EDDEFIRNQLKEISSSTESQKKEETKGKGKIT-AGKHRRLTRKSS--TSIDEDAGRRHSW 1629
Query: 293 DDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSD 352
D D + SP ++T+ +ES E++ G R + +E ++
Sbjct: 1630 HDEDDEAFDE----SPELKYRETKSQESEELVVTGGGGLRRF--------KTIELNSTIA 1677
Query: 353 QALEALSASLGTR---QAEPELDLRSIKEVDEAKAKEE-----------------KLEKC 392
A S+ T EPEL++ S+ + E +++ E +
Sbjct: 1678 DKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSL 1737
Query: 393 GEDDETIPSEYR-----LKPATDKDGKPLLP---EPEEKPKPRSESELIDELSEDFDRSE 444
ED ++ PS + + A + PLLP + E+ + R E EL+ E + + +
Sbjct: 1738 DEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQ 1797
Query: 445 CKEKPSKPTEKTEESKAAA 463
+ K S K ++ + A
Sbjct: 1798 QQRKSSSKKSKKDKDELRA 1816
Score = 50.1 bits (118), Expect = 8e-06
Identities = 151/766 (19%), Positives = 263/766 (34%), Gaps = 92/766 (12%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPG-----------------EKKG 43
+ P + P P P + A + HE ++ P++P + G
Sbjct: 298 LPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPG 357
Query: 44 SDEKKAASLGSSQSSRTYAGGTASAT-----KVSASSGATSKSSSMNPTETKAIPVSQQM 98
+ + A LG ++ G ++ K A K+ + P K P +QQ+
Sbjct: 358 TTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAK--PPTQQV 415
Query: 99 EGPHLPNKKKHKKQAVKTEPEKKS--QSTKPKSLPKQASDTGSNDAHNKKAVSRSAE--- 153
P ++ + K K+ Q P +P Q + G A ++
Sbjct: 416 GTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPG 475
Query: 154 --QQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKP 211
+ P ++ K PQ SA S S KP ++ +P P +KP
Sbjct: 476 PAKPPPQQPGPAKPPPQQPGSAKPPSQ---QPGSTKPPPQQPGPAKPSPQQPGSTKPPSQ 532
Query: 212 SGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRE 271
S +A + T+ + T +G + P S ++ + +P
Sbjct: 533 QPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQ--GLPKTICP 590
Query: 272 LLAKKEGITGPPAD--------------SSKPIGPDDAIDALSS--DFTCGSPTAAGKKT 315
L E + P S P+ + + C A G
Sbjct: 591 LCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDL 650
Query: 316 EKEESTEVLKAQSAGTVRSAA----PPQEKKRKVEKDTMSDQALEALSASLGTRQAEPEL 371
S+ K ++A ++A PQ ++ +KD Q LS + ++ P +
Sbjct: 651 APVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQ---DLSKAPEPKKPPPLV 707
Query: 372 DLRSIKEVDEAKAKE----EKLEKCGEDDE-TIPSEYRLKP-ATDKDGKPLLPEPEEKPK 425
++ AKAK+ + L K E ++PSE P A DK +P + +P
Sbjct: 708 KQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLV 767
Query: 426 PRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPE 485
S + ++ +S+ +EK + P + + + P E V A P
Sbjct: 768 SSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFD----SKAIPR 823
Query: 486 PATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDY 545
PA+ + ++S G+K+ DP K K + K + K K PP
Sbjct: 824 PASDSKIISHPGPS--SESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGP 881
Query: 546 RLEEVKDKDGKPLLPK-ESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF--EDAKLAAA 602
R + PK + + + ++ + DA + PQ + K A + +
Sbjct: 882 RPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQ 941
Query: 603 ISEVVSQT----PASTTQAGAPPRDT-SQSDKDLDDALDKLSDSLGQRQPDPDENKPMED 657
S ++S P S + GAP + + S K S GQ P P ++ P
Sbjct: 942 ASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPK---STGQAPPAPAKSIP--- 995
Query: 658 KVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSE 703
VK++ KA +KL + + P R + KP PP K S+
Sbjct: 996 -VKKETKAPAAEKLEPKAEQAPTVKR----TETEKKP--PPIKDSK 1034
Score = 49.7 bits (117), Expect = 1e-05
Identities = 149/726 (20%), Positives = 264/726 (36%), Gaps = 143/726 (19%)
Query: 56 QSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVK 115
Q+ R +G K+ + S PTE+ SQ+ P K ++Q VK
Sbjct: 1110 QTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESS----SQKTAVPPQVKLVKKQEQEVK 1165
Query: 116 TEPEKK-----SQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDM 170
TE EK ++ + +P + + + SA Q+ E K P++
Sbjct: 1166 TEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEE 1225
Query: 171 ISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTL-- 228
E + P DKK ++ T A P E K D KS + A + L +
Sbjct: 1226 KIRSEEKKPLLEEKKPTPEDKKLLPEAKTSA-PEEQKHDLL--KSQVQIAEEKLEGRVAP 1282
Query: 229 -----GGPEETEEEN----TTYTGPEVSDPMSSTYIEE-----LGKREVTIPPKYRELLA 274
G +T+ E T + P+ D + T E+ K + P K +
Sbjct: 1283 KTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEK---T 1339
Query: 275 KKEGITGPPADSSKPIGPDDAIDA-LSSDFTCGSPTAAGK-----KTEKEESTEVLKAQS 328
+KE + S +P P D SSD G ++ G+ T++++ + LK S
Sbjct: 1340 EKEDDKSDTSSSQQPKSPQGLSDTGYSSD---GISSSLGEIPSLIPTDEKDILKGLKKDS 1396
Query: 329 AGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSI-----KEVDEAK 383
S + P + K+E +S LEA +++L ++E + + K+ ++ +
Sbjct: 1397 FSQESSPSSPSDLA-KLESTVLS--ILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQ 1453
Query: 384 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 443
+ E LE ++E S+ K KD + +P ++ + +SE +D+++
Sbjct: 1454 SLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDH---KEKSEFVDDITTR---- 1506
Query: 444 ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD 503
+P + EES + +PV + RTS+ S S
Sbjct: 1507 ------REPYDSVEESSESENSPVPQRKRRTSVGSSSS---------------------- 1538
Query: 504 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES 563
++ K+ED + GE+E+ I +E D+D
Sbjct: 1539 --------------------DEYKQEDSQGSGEEEDFIRKQI-IEMSADEDAS------- 1570
Query: 564 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFE-DAKLAAAISEVVSQTPASTTQAGAPPR 622
++F+ + L E S ++ + + K+ A +++ +++ A R
Sbjct: 1571 ----GSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRR 1626
Query: 623 DTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY 682
S D+D D+A D+ S L R+ E+ E+ V R K E + TI +Y
Sbjct: 1627 H-SWHDED-DEAFDE-SPELKYRETKSQES---EELVVTGGGGLRRFKTIELNSTIADKY 1680
Query: 683 --------RHLLDDNGQDKPVKPPTKKSEDSKK-------------PADDQDPIDALSGD 721
L D + ++ T ED + P + +L D
Sbjct: 1681 SAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDED 1740
Query: 722 LDSCPS 727
DS PS
Sbjct: 1741 SDSSPS 1746
Score = 45.1 bits (105), Expect = 3e-04
Identities = 166/869 (19%), Positives = 273/869 (31%), Gaps = 159/869 (18%)
Query: 2 SQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGS----DEKKAASLGSSQS 57
S P ++ P P R A + ++ PG + + K L
Sbjct: 90 SHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHK 149
Query: 58 SRTYAGGTASATKVSASSGATSK---------SSSMNPTETKAIPVSQQMEG-------P 101
S G + +SA S +K S + TK V Q+ +G P
Sbjct: 150 SSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKP 209
Query: 102 HL---PNKKKHKKQAVKTEP------EKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSA 152
L P K K+Q +P K S +P+ + Q TG +
Sbjct: 210 PLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDH 269
Query: 153 EQQPSEK-STEPKTKPQDMISAGGESVAGITAISGKPGDKKK------------EKKSLT 199
+ P ++ ++ P+TK D++ GESV KP ++ EK
Sbjct: 270 AKLPLQRDASRPQTKQADIVR--GESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPG 327
Query: 200 PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSST-----Y 254
PA P P +PSG + A + P T + GP P T
Sbjct: 328 PAKP----PAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGP-AKPPAQQTGSEKPS 382
Query: 255 IEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAA--- 311
E+ G + + PP + A++ G PP P L S PT
Sbjct: 383 SEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQ 442
Query: 312 ----GKKTEKEESTEVLKAQSAGTVRS-------AAPPQEKKRKVEKDTMSDQALEALSA 360
GK ++ AQ G + A PP ++ + + + S
Sbjct: 443 QPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQ 502
Query: 361 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 420
G+ + P+ + + + + ++ G + KP+ + KP+
Sbjct: 503 QPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTG 562
Query: 421 EEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVC---RTS 475
KP P S+ ++ C P T E P + C +T+
Sbjct: 563 SGKPLQPPTVSPSAKQPPSQGLPKTIC------PLCNTTELLLHVPEKANFNTCTECQTT 616
Query: 476 MCSIQSAPPEP------------ATLKGTVPDD--------------AVEALADSLGKKE 509
+CS+ P P +K + D A ++ K
Sbjct: 617 VCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSS 676
Query: 510 ADPEDGKPVMDKVKEKAKEEDREKLGEKEETIP----------PDYRLEEVKDKDG--KP 557
P+ P K+ A ++D K E ++ P P + ++ + D KP
Sbjct: 677 PQPQQTSPK----KDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKP 732
Query: 558 LLPKE----SKEQLPPMSEDF-----LLDALSEDFSGPQNASSLKFEDAKLAAAISEVVS 608
PKE S++ P+++D ++ ++ S + +K+ + E
Sbjct: 733 APPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEE--K 790
Query: 609 QTPASTTQAGAP------------PRDTSQ-----SDKDLDDALDKLSDSLGQRQPDPDE 651
TP T + P P D+ SD + S+S GQ+Q DP +
Sbjct: 791 TTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQ 850
Query: 652 NKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADD 711
K K + K + K + PP R GQ P + S KP +
Sbjct: 851 KKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPR---PTAGQTVPT------PQQSPKPQEQ 901
Query: 712 QDPIDALSGDLDSCP-STTETSQNTAKDK 739
G + P S T Q T K
Sbjct: 902 SRRFSLNLGSITDAPKSQPTTPQETVTGK 930
Score = 31.6 bits (70), Expect = 2.9
Identities = 33/145 (22%), Positives = 60/145 (41%), Gaps = 19/145 (13%)
Query: 29 EKTSESPSKPGEKKGSDEKKAASL--GSSQSSRTYAGGTASATKVSASSGATSKSSSMNP 86
E ++SP +GS A+S G+S +S +S + S SS + K S
Sbjct: 1702 ESLTDSPEDRSRGEGSSSLHASSFTPGTSPTS------VSSLDEDSDSSPSHKKGESKQQ 1755
Query: 87 TETKAIPVSQQMEGPHLPN-KKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNK 145
+ + P GP LP + +++ ++ E E + K + + +Q + S K
Sbjct: 1756 RKARHRP-----HGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSS-----K 1805
Query: 146 KAVSRSAEQQPSEKSTEPKTKPQDM 170
K+ E + + PKT P ++
Sbjct: 1806 KSKKDKDELRAQRRRERPKTPPSNL 1830
>gi|109637791 transcription factor-like nuclear regulator [Homo
sapiens]
Length = 2624
Score = 60.5 bits (145), Expect = 6e-09
Identities = 84/363 (23%), Positives = 150/363 (41%), Gaps = 50/363 (13%)
Query: 309 TAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMS-DQALEALSASLGTRQA 367
T+ + E +T+ +++ T R A P+EK V DT+ + L+A+ + R+
Sbjct: 855 TSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREK 914
Query: 368 EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPR 427
PE+ +D + ++ LE+ G R + + K+G PEE KP
Sbjct: 915 TPEV-------IDATEEIDKDLEEAG----------RREISPQKNG------PEEV-KPL 950
Query: 428 SESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPA 487
E E +L + S +EK + T+ TEE + + + T I P
Sbjct: 951 GEVET--DLKATGNESSPREKTPEVTDATEE--------IDKNLEETGRRKISPRENGPE 1000
Query: 488 TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRL 547
+K P D +E ++ G++ + E V+D +E EE + E P + L
Sbjct: 1001 EVK---PVDEMETDLNATGRESSPREKTPEVIDATEEIDLEET------EREVSPQENGL 1051
Query: 548 EEVKDK-DGKPLLPKESKEQLPPMSEDFLLDALSE---DFSGPQNASSLKFEDAKLAAAI 603
EEVK + + L ++ P ++DA+ E D + S + + +
Sbjct: 1052 EEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPL 1111
Query: 604 SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA 663
E+ QT T PR+ + D + +DK + G+R+ P+EN P E K ++
Sbjct: 1112 GEM--QTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEM 1169
Query: 664 KAE 666
+ +
Sbjct: 1170 ETD 1172
Score = 33.9 bits (76), Expect = 0.59
Identities = 138/736 (18%), Positives = 268/736 (36%), Gaps = 104/736 (14%)
Query: 103 LPNKKKHKKQAVKTEPEKKSQSTKPKS--LPKQASDTGSNDAHNKKAVSRSAEQQPSEKS 160
L ++K K+++VK K+ +STKP+ K+ + G N+ ++ SR ++ + S+K
Sbjct: 375 LAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKD 434
Query: 161 TEPKTKPQDMIS-AGGESVAGITAISGKPGDKKKEK-------KSLTPAVPVESKPDK-P 211
+ + +S E VA ++ K +KK+ +L V++ P K
Sbjct: 435 AQTVEEESLTLSREDAEQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGE 494
Query: 212 SGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRE 271
K+ A +L + E +E + + E++ KR I
Sbjct: 495 KHKNKCQAIRPELKE-----GECSKEQMLSCTQNIDGIVGFASTEKVEKRTDPILS---- 545
Query: 272 LLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKE-----------ES 320
L+ ++ T +SS+ D + C A G E+ +
Sbjct: 546 -LSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQ 604
Query: 321 TEVLKAQSAGTVRSAAPPQEK--------KRKVEKDTMSDQALEALSASLGTRQAEPELD 372
TE +K G + P + + K E ++ + + ++ + + LD
Sbjct: 605 TENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLD 664
Query: 373 LRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESEL 432
+ ++ + + E + GE + + +LK + L +P+ +E +
Sbjct: 665 ILRMETTERENPEAETVSVLGEKN-CLQEGSQLKALRPVQVRGRLQKPKPNAGKAAERKE 723
Query: 433 I----DELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPAT 488
I +E+ + +++E + + T + E ++ + + + PE
Sbjct: 724 ILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQ----------PEKND 773
Query: 489 LKGTVPDDAVEALADSLGKKE---ADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDY 545
V D + L + L +E A+ + P++ +K K G +E +
Sbjct: 774 SFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTGRREIS----- 828
Query: 546 RLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDA-----LSEDFSGPQNASSLKFEDAKLA 600
EEV +K S E + E LD + + + + S LK E + A
Sbjct: 829 SKEEVLEK------ILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLK-ETGRRA 881
Query: 601 AA----ISEVVSQTPASTTQAGAPPRDTSQSDK-----DLDDALDKLSDSLGQRQPDPDE 651
+ I +V+ T T A R+ +K D + +DK + G+R+ P +
Sbjct: 882 ISPREKILDVIDDTIEMETGLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQK 941
Query: 652 NKPMEDK----VKEKAKA-----EHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKS 702
N P E K V+ KA R+K E D E L++ G+ K P +
Sbjct: 942 NGPEEVKPLGEVETDLKATGNESSPREKTPEVTDA-TEEIDKNLEETGRRK--ISPRENG 998
Query: 703 EDSKKPADDQD-PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNG-------G 754
+ KP D+ + ++A + T E T + ++ +NG G
Sbjct: 999 PEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLG 1058
Query: 755 KAKDSAKTTEETSKPK 770
+ + K T S P+
Sbjct: 1059 EMETDLKATGRDSFPR 1074
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 59.7 bits (143), Expect = 1e-08
Identities = 140/683 (20%), Positives = 259/683 (37%), Gaps = 142/683 (20%)
Query: 79 SKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTG 138
+KS + ++ ++EG +++ +K K + EKK Q + K+ +
Sbjct: 7 NKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEEL- 65
Query: 139 SNDAHNKKAVSRSAEQQPSEKSTEPKT-KPQDMISAGGESVAGITAISGKPGDK-KKEKK 196
S +A KA + +P+E + E T K + G+ + S + DK K KK
Sbjct: 66 SLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKK 125
Query: 197 SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIE 256
+ P V + S D D + L G + ++ N + G E D +S I+
Sbjct: 126 TAKPKVEMYSGSDD-------DDDFNKLPKKAKG--KAQKSNKKWDGSE-EDEDNSKKIK 175
Query: 257 ELGKREVT--IPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKK 314
E + + + E L ++G +KP GP+ D + T A KK
Sbjct: 176 ERSRINSSGESGDESDEFLQSRKG--QKKNQKNKP-GPNIESGNEDDDASFKIKTVAQKK 232
Query: 315 TEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLR 374
EK+E + KKR EK + R+ + + +L
Sbjct: 233 AEKKER------------------ERKKRDEEKAKL--------------RKLKEKEELE 260
Query: 375 SIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELID 434
+ K+ D++K KE + + ++ET+ S+ + ++P EEK + + +E D
Sbjct: 261 TGKK-DQSKQKESQRKF---EEETVKSKVTVDTG-------VIPASEEKAETPTAAE--D 307
Query: 435 ELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVP 494
+ D + + K+K + EK +E K P AT+K
Sbjct: 308 DNEGDKKKKDKKKKKGEKEEKEKEKKKG---------------------PSKATVKAM-- 344
Query: 495 DDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKD 554
+A+ L + +++ + E+ +++++ K KEE+R + ++E + +E K+
Sbjct: 345 QEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKE 404
Query: 555 GKPLLPKE----------------------SKEQLP---PMSEDFLLDALSEDFSGPQNA 589
GK L + SK+ LP P+ ED + + + +
Sbjct: 405 GKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVS 464
Query: 590 SSLKFEDAKLAAAISEVVSQTPAS--TTQAGAPPRDTSQSDKDLDDALDKLSDSLGQR-- 645
S++ L AA+ + P T P + D LDD SD ++
Sbjct: 465 ESME-----LCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVE 519
Query: 646 -------------QPDPDENKPMEDKVKEKAKAEHRDKLG----ERDDTIPPEYRHLLDD 688
+ + +E + ED+ E+ + E + G E D+ + E D
Sbjct: 520 GNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDE-----KD 574
Query: 689 NGQDKPVKPPTKKSEDSKKPADD 711
+G+ KP + S DS+ +DD
Sbjct: 575 SGKTLDKKPSKEMSSDSEYDSDD 597
Score = 58.9 bits (141), Expect = 2e-08
Identities = 128/605 (21%), Positives = 225/605 (37%), Gaps = 99/605 (16%)
Query: 88 ETKAIPVSQQMEGPHLPNKKKHKKQAVKT---------EPEKKSQSTKPKSLPKQASDTG 138
ET A+ ++ E KK K Q K E E K +K + PK +G
Sbjct: 77 ETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSG 136
Query: 139 SNDAHN-----KKAVSRSAEQQPS------EKSTEPKTKPQDMISAGGESV-AGITAISG 186
S+D + KKA ++ + ++ K K + I++ GES +
Sbjct: 137 SDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQS 196
Query: 187 KPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEV 246
+ G KK +K P + ++ D S K I T+ + ++E E
Sbjct: 197 RKGQKKNQKNKPGPNIESGNEDDDASFK----------IKTVAQKKAEKKERERKKRDEE 246
Query: 247 SDPMSSTYIEE---LGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDF 303
+ +E GK++ + K +E K E T SK I A S+
Sbjct: 247 KAKLRKLKEKEELETGKKDQS---KQKESQRKFEEETV----KSKVTVDTGVIPA--SEE 297
Query: 304 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMS--DQALEALSAS 361
+PTAA E ++ + K + +EKK+ K T+ +AL L
Sbjct: 298 KAETPTAAEDDNEGDKKKKDKKKKKG---EKEEKEKEKKKGPSKATVKAMQEALAKLKEE 354
Query: 362 LGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPE 421
++ E E ++ ++E++ + +EE+LE+ + + E K K+GK LL + +
Sbjct: 355 EERQKREEEERIKRLEELEAKRKEEERLEQ-EKRERKKQKEKERKERLKKEGK-LLTKSQ 412
Query: 422 EKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSM--CSI 479
+ + R+E+ L ++ + P K ++ + P + SM C+
Sbjct: 413 REARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCA- 471
Query: 480 QSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEE 539
AVE + + +KE P +P ++ E A +D E + EE
Sbjct: 472 -----------------AVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEE 514
Query: 540 TIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKL 599
T + ++ K+ P+E +E+ ED + E+ G S ED K+
Sbjct: 515 TEKVEGNKVHIEVKEN----PEEEEEEEEEEEEDEESEE-EEEEEGESEGSEGDEEDEKV 569
Query: 600 AAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKV 659
+ D S K LD K S + D D+++ E++
Sbjct: 570 S----------------------DEKDSGKTLDKKPSKEMSS--DSEYDSDDDRTKEERA 605
Query: 660 KEKAK 664
+KAK
Sbjct: 606 YDKAK 610
Score = 52.0 bits (123), Expect = 2e-06
Identities = 97/480 (20%), Positives = 177/480 (36%), Gaps = 61/480 (12%)
Query: 38 PGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQ 97
P + KG +K S+ + +++++S + +S + +
Sbjct: 147 PKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKN 206
Query: 98 MEGPHLPN-----------KKKHKKQAVKTEPEKKSQSTKPKSL----PKQASDTGSNDA 142
GP++ + K +K+A K E E+K + + L K+ +TG D
Sbjct: 207 KPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQ 266
Query: 143 HNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISG-KPGDKKKEKKSLTPA 201
+K R E++ + T +I A E TA GDKKK+ K
Sbjct: 267 SKQKESQRKFEEETVKSKVTVDT---GVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKG 323
Query: 202 VPVESKPDKPSGKSGMDA-ALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGK 260
E + +K G S A+ + + L EE ++ + + + EE +
Sbjct: 324 EKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLE 383
Query: 261 REVTIPPKYRE------------LLAKKEGITGPPADSSKPIGPDDAIDALSSD-FTCGS 307
+E K +E LL K + A+++ + ++ S D
Sbjct: 384 QEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKR 443
Query: 308 PTAAGKKTEK----------EESTEVLKA-----QSAGTVRSAAPPQEKKRKVEKDTMSD 352
P KK +K ES E+ A Q PP E + + + +
Sbjct: 444 PIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGL 503
Query: 353 QALEALSASLGTRQAE-----------PELDLRSIKEVDEAKAKEEKLEKCGEDDETIPS 401
EA+++ T + E PE + +E +E + EE+ E+ GE + +
Sbjct: 504 DDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGD 563
Query: 402 EYRLKPATDKD-GKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESK 460
E K + +KD GK L +P ++ SE + D+ +++ +R+ K K + E SK
Sbjct: 564 EEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKE-ERAYDKAKRRIEKRRLEHSK 622
Score = 41.6 bits (96), Expect = 0.003
Identities = 133/676 (19%), Positives = 234/676 (34%), Gaps = 167/676 (24%)
Query: 164 KTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDD 223
K K +D + A I G K++E P +SK K K D DD
Sbjct: 6 KNKSEDSTKDDIDLDALAAEIEGAGAAKEQE--------PQKSKGKKKKEKKKQDFDEDD 57
Query: 224 LIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPP 283
++ +E EE + G + + E + E T K KK+G G
Sbjct: 58 IL------KELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDK------KKKGQKG-- 103
Query: 284 ADSSKPIGPDDAIDALSSDFTCGSPTAAGKK-----TEKEESTEVLKAQSAGTVRSAAPP 338
K D+ + L + TA K ++ ++ L ++ G + +
Sbjct: 104 ---KKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKK 160
Query: 339 QEKKRKVEKDTMSDQALEALSASLGTRQAEPE-LDLRSIKEVDEAKAKEEKLEKCGEDDE 397
+ + E ++ + +++S + E L R ++ ++ +E EDD+
Sbjct: 161 WDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDD 220
Query: 398 TIPSEYRLKPATDKDGKPLLPE----PEEKPKPRSESELIDELSEDFDRSECKEKPSKPT 453
+ +++K K + E EEK K R E + + D+S+ KE K
Sbjct: 221 ---ASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFE 277
Query: 454 EKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPE 513
E+T +SK G +P A E A++ E D E
Sbjct: 278 EETVKSKVTVDT-------------------------GVIP--ASEEKAETPTAAEDDNE 310
Query: 514 DGKPVMDKVKEKAKEEDRE--------------------KLGEKEETIPPD-----YRLE 548
K DK K+K ++E++E KL E+EE + RLE
Sbjct: 311 GDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLE 370
Query: 549 EV--------------------KDKDGKPLLPKE-------------------------- 562
E+ K+K+ K L KE
Sbjct: 371 ELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQG 430
Query: 563 ----SKEQLP---PMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTT 615
SK+ LP P+ ED + + + + S+ +L AA+ + P
Sbjct: 431 VEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESM-----ELCAAVEVMEQGVP---E 482
Query: 616 QAGAPPRDTSQSDKDLDDA-LDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGER 674
+ PP + ++D +DA LD + + E + +VKE + E ++ E
Sbjct: 483 KEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEE 542
Query: 675 DDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD--------PIDALSGDLDSCP 726
+D E ++ G+ + ++ E+ +K +D++D P +S D +
Sbjct: 543 EDEESEEEE---EEEGESE----GSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDS 595
Query: 727 STTETSQNTAKDKCKK 742
T + A DK K+
Sbjct: 596 DDDRTKEERAYDKAKR 611
Score = 37.7 bits (86), Expect = 0.041
Identities = 69/374 (18%), Positives = 137/374 (36%), Gaps = 64/374 (17%)
Query: 313 KKTEKEESTE--------VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 364
+K + E+ST+ + + AG + P + K +K ++ D + + L
Sbjct: 5 QKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE 64
Query: 365 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 424
E + +++ +E K E E+ D+ + K + D + L + + K
Sbjct: 65 LSLEAQ-GIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKS 123
Query: 425 KPRSES--ELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSA 482
K ++ E+ +D D ++ +K +K+ + + + I S+
Sbjct: 124 KKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSS 183
Query: 483 PPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKE------KAKEEDREKLGE 536
G D++ E L G+K+ P ++ E K K ++K +
Sbjct: 184 --------GESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEK 235
Query: 537 KEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFED 596
KE R + +D++ L + KE+L +D Q S KFE+
Sbjct: 236 KE-------RERKKRDEEKAKLRKLKEKEELETGKKD----------QSKQKESQRKFEE 278
Query: 597 AKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPME 656
+ + ++ PAS +A P T+ D D + +K +
Sbjct: 279 ETVKSKVTVDTGVIPASEEKAETP---TAAED-------------------DNEGDKKKK 316
Query: 657 DKVKEKAKAEHRDK 670
DK K+K + E ++K
Sbjct: 317 DKKKKKGEKEEKEK 330
Score = 37.0 bits (84), Expect = 0.069
Identities = 40/168 (23%), Positives = 77/168 (45%), Gaps = 26/168 (15%)
Query: 623 DTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY 682
D+++ D DLD ++ + ++ +P ++K + K K+K + D L E ++ + E
Sbjct: 11 DSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE-LSLEA 69
Query: 683 RHL-----------LDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTET 731
+ + ++N ++ K KK + KK + D + + L D DS
Sbjct: 70 QGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELE-DKDS------K 122
Query: 732 SQNTAKDKCKKAASS------SKAPKNG-GKAKDSAKTTEETSKPKDD 772
S+ TAK K + + S +K PK GKA+ S K + + + +D+
Sbjct: 123 SKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN 170
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 59.3 bits (142), Expect = 1e-08
Identities = 118/544 (21%), Positives = 214/544 (39%), Gaps = 55/544 (10%)
Query: 4 PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAAS---LGSSQSSRT 60
PG+ +P + A A +T E+ SES S+ E S+E+ A+ L + S +T
Sbjct: 234 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSE--ESSDSEEETPAAKALLQAKASGKT 291
Query: 61 YAGGTASA-TKVSASSGAT-SKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQA-VKTE 117
G ASA K S GA + P KA ++ + + +++A + +
Sbjct: 292 SQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAK 351
Query: 118 PEKKSQSTKPKSLP-KQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGE 176
P K+ + S P K++ G+ A +K +A+ Q ++ + ++ ++ + E
Sbjct: 352 PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES-DSDRE 410
Query: 177 SVAGITAISGKPGDKKKEKKSLTPAVPVESKP------DKPSGKSGMDAALDDLIDTLGG 230
++A + A KP K + K PA + P P GK G +
Sbjct: 411 ALAAMNAAQVKPLGKSPQVK---PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEED 467
Query: 231 PEETEEENTTYTGPEVSDPMSSTYIEELGK----REVTIPPKYRELLAKKEGITGPPADS 286
E + EE++ + EV ++ + LG + + P K +K G +
Sbjct: 468 SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGP---PQKAGPVAVQVKA 524
Query: 287 SKPI----GPDDAIDALSSDFTCGSPTAA-GKKTEKEESTEVLKAQSAGTVRSAAPPQEK 341
KP+ +++ D+ S+ + TAA K K T+ ++ T + P
Sbjct: 525 EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRV 584
Query: 342 KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE------EKLEKCGED 395
+ + + + S ++ P D S +E D + K + + G+
Sbjct: 585 GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKG 644
Query: 396 DETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK 455
+ + +K + + P+LP K P + +++ E ED + SE E
Sbjct: 645 LQVKAASVPVKGSLGQGTAPVLP---GKTGP-TVTQVKAEKQEDSESSE--------EES 692
Query: 456 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTV--PDDAVEALADSLGKKEADPE 513
E AA+PA V +V +T + +A P+ KGT+ P V A A + K+ P
Sbjct: 693 DSEEAAASPAQVKTSVKKTQAKANPAAARAPSA-KGTISAPGKVVTAAAQA---KQRSPS 748
Query: 514 DGKP 517
KP
Sbjct: 749 KVKP 752
Score = 49.3 bits (116), Expect = 1e-05
Identities = 154/862 (17%), Positives = 283/862 (32%), Gaps = 128/862 (14%)
Query: 7 KPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTA 66
+ A+P P R V ++ +S S E+ SD + A++ ++Q G +
Sbjct: 371 RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSS-SEESDSDREALAAMNAAQVKPL---GKS 426
Query: 67 SATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTK 126
K +++ G M P A PV GP P+ + K + ++S +
Sbjct: 427 PQVKPASTMG-------MGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSS 479
Query: 127 PKSLPK--------------QASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMIS 172
+P QA T S + A Q +EK + ++
Sbjct: 480 DGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 539
Query: 173 AGG--ESVAGITAISGKPGDKKKE-----KKSLTPA------VPVESKPDKPSGKSGMDA 219
+ E+ A +TA KP K + KK+ T A V V ++ + +G + A
Sbjct: 540 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 599
Query: 220 ALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGI 279
+ GG + E++++ + + + + + V K ++ A +
Sbjct: 600 GSSPAV--AGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVG---KGLQVKAASVPV 654
Query: 280 TGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 339
G + P+ P PT K EK+E +E + +S +A+P Q
Sbjct: 655 KGSLGQGTAPVLPGKT-----------GPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 703
Query: 340 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 399
K + ++ A ++ GT A ++ + + + +K + + ++ +
Sbjct: 704 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 763
Query: 400 PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSE--CKEKPSKPTE--- 454
P+ GK + + + P +S +E S+ + +E + KPS T
Sbjct: 764 ARGPASVPSV---GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIR 820
Query: 455 ------KTEESKAAAPAPVSEAVCRTSMCSIQ---SAPPEPATLKGTVP----------- 494
K K AAP P + + Q + E + G P
Sbjct: 821 AALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP 880
Query: 495 ---------DDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDY 545
A A + + + P + + + E + E + + + P
Sbjct: 881 PLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGI 940
Query: 546 RLEEVKDKDGKP-LLPKESKEQLPPMSEDF-LLDALSEDFSGPQ----NASSLKFEDAKL 599
R V P + PK S E + D ++ Q N +SL A L
Sbjct: 941 RTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAAL 1000
Query: 600 AAAISEV-VSQTPASTTQAGA------------PPRDTSQSDKDLDDALDKLSDSLGQRQ 646
+ +Q P + TQ + P+ TS K + + Q
Sbjct: 1001 KVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQAT 1060
Query: 647 PDPDENKPMEDKVKEKAKAEHRDK-----------LGERDDTIPPEYRHLLDDNGQDKPV 695
P+ + ED + +E + +G ++ +D V
Sbjct: 1061 KAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVV 1120
Query: 696 KPPTKKSEDSKKP--ADDQDPIDALSGDLDSCPSTTET----SQNTAKDKCK-KAASSSK 748
P P + LDS PS + T K + K + A+
Sbjct: 1121 APSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGML 1180
Query: 749 APKNGGKAKDSAKTTEETSKPK 770
+PK GGK S T +++ KPK
Sbjct: 1181 SPKTGGKEAASGTTPQKSRKPK 1202
Score = 44.7 bits (104), Expect = 3e-04
Identities = 114/564 (20%), Positives = 172/564 (30%), Gaps = 128/564 (22%)
Query: 308 PTAAGKKTEKEESTEVLKAQSA-------GTVRSAAPPQEKKRKVEKDT----------- 349
P + + +E+EE E A++ +V A P K K + +T
Sbjct: 81 PISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMP 140
Query: 350 ---MSDQALEALSASLGTRQAEPELDLRSIKEVDE--------AKAK------------- 385
LS + AEP + + E +E A AK
Sbjct: 141 HPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSS 200
Query: 386 EEKLEKCGEDDETIPSEYRL-------KPATDKDGKPLLPEPEEKPKPRSESELIDELSE 438
E+ E D + + ++ PA GK P P K + + E
Sbjct: 201 EDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEE 260
Query: 439 DFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAV 498
D + S E+ S E+T +KA A S +TS SAP + + KG P
Sbjct: 261 DSESSS--EESSDSEEETPAAKALLQAKASG---KTSQVGAASAPAKESPRKGAAP---- 311
Query: 499 EALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEK---EETIP---------PDYR 546
A P P + K + +EED + E+ EE P P R
Sbjct: 312 -----------APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVR 360
Query: 547 LEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEV 606
K+ P++ PP + + SS + D+ A +
Sbjct: 361 AASAPAKES----PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMN 416
Query: 607 VSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 666
+Q P T A +G P K ED E + E
Sbjct: 417 AAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEED--SESSSEE 474
Query: 667 HRDKL-GERDDTIPPEYRHLLDDNGQDKPVKPPTK-----------------------KS 702
D GE + P L + Q KP P K S
Sbjct: 475 SSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESS 534
Query: 703 EDSKKPADDQDPIDALSG----------DLDSCPSTTETSQNTAKDKCKKAASSSKAPKN 752
E+S AD ++ A++ +CP T T TA K ++AP+
Sbjct: 535 EESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNT---TASAKVAPVRVGTQAPRK 591
Query: 753 GGKAKDSAKTTEE----TSKPKDD 772
G A A ++ T +P +D
Sbjct: 592 AGTATSPAGSSPAVAGGTQRPAED 615
Score = 42.0 bits (97), Expect = 0.002
Identities = 77/392 (19%), Positives = 137/392 (34%), Gaps = 56/392 (14%)
Query: 2 SQPGQKPAASPRPR--RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSR 59
S G PA SP+ +A + + + ++ P S++ +S GS +
Sbjct: 1025 SAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGE 1084
Query: 60 TYAGGTASATKVSASSGATS---KSSSMNPTETKAIPVSQQM-EGPHLPNKKKHKKQAVK 115
G ++ T V + T + ++ +E + SQ + G P QA K
Sbjct: 1085 GPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASK 1144
Query: 116 TEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVS---------RSAEQQPSEKSTEPKTK 166
P+ S + +L + G +A ++A +A +KS +PK
Sbjct: 1145 ATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1204
Query: 167 PQDMISAGGESVAGIT-AISGKPGDKKKEK------KSLTPAVPVESKP----------- 208
+ ++ + IT + G+P + + K LT + E K
Sbjct: 1205 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1264
Query: 209 -----------DKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT--GPEVSDPMSSTYI 255
D+P+ ++ L GG E T+ T G D S
Sbjct: 1265 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1324
Query: 256 EELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKT 315
E+ GK L + P + K +G + D + + +K
Sbjct: 1325 EKKGKGS----------LGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKK 1374
Query: 316 EKEESTEVLKAQSAGTVRSAAPPQEKKRKVEK 347
+KE+ + KA+ A T S +P Q+KK+K +K
Sbjct: 1375 DKEKKEKKKKAKKASTKDSESPSQKKKKKKKK 1406
Score = 39.3 bits (90), Expect = 0.014
Identities = 156/876 (17%), Positives = 298/876 (34%), Gaps = 124/876 (14%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
M+ KPA P+ A ++T+ S K + P + G + + K + + SS
Sbjct: 550 MTAAQAKPALKI-PQTKACPKKTNTTASAKVA--PVRVGTQ--APRKAGTATSPAGSSPA 604
Query: 61 YAGGTASATKVSASSGATSKSS-----SMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVK 115
AGGT + S+SS + ++ + K++ Q++ +P K +
Sbjct: 605 VAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAP 664
Query: 116 TEPEKKSQS-TKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKP------- 167
P K + T+ K+ ++ S++ ++ +++A + A+ + S K T+ K P
Sbjct: 665 VLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPS 724
Query: 168 -QDMISAGGESVAGI---------------------TAISGKPGDKKKEKKSLTPAVPVE 205
+ ISA G+ V T ++ P K++ A +
Sbjct: 725 AKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQ 784
Query: 206 SKPDKPSGKSGMDAALDDLIDTLGG----------------PEETEEENTTYTGPEVSDP 249
+ P++ SG S ++ ++ +TL +E+ + T P + P
Sbjct: 785 TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP 844
Query: 250 M---------SSTYIEE----------LGKREVTIPPKYRELLAKKEGITGPPADSSKPI 290
S + EE + +V PP + GP A ++
Sbjct: 845 SAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLI--FVDPNRSPAGPAATPAQAQ 902
Query: 291 GPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVL--------------------KAQSAG 330
A +S+ T S ++ + + +T+ L KA AG
Sbjct: 903 AASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAG 962
Query: 331 TVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLE 390
S + K +++ + Q + ASL QA ++ + E A+ +
Sbjct: 963 ASSSKESSRISDGK-KQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSS 1021
Query: 391 KCGEDDETIPSEYRLKPA-----TDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSEC 445
T+P+ + T+K KP LPE ++ K S+ ++ S+ SE
Sbjct: 1022 GVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEE 1081
Query: 446 KEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQS--APPEPATLKGTVPDDAVEALAD 503
+ + + P+ V T+ S + P + L G + A +
Sbjct: 1082 DGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPA--N 1139
Query: 504 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET---IPPDYRLEEVKDKDGKPLLP 560
S K D P + + D ++ + ++ + P +E
Sbjct: 1140 SQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSR 1199
Query: 561 KESKEQLPPMSEDFLLDA-LSEDFSG---PQNASSLKFEDAKLAAAISEVVSQTPASTTQ 616
K K P + L + +++ G P N + ++ K+ + E + TT+
Sbjct: 1200 KPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTK 1259
Query: 617 AGAPPRDTSQSDKDLDDA------LDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDK 670
+ S+ K D K LG + P + K KA+ RDK
Sbjct: 1260 ESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAK-RDK 1318
Query: 671 LGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTE 730
D + + L G + +K + + D +P + S +
Sbjct: 1319 AS--GDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNP-KSKKEKKKSDKRKKD 1375
Query: 731 TSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEET 766
+ K K KKA++ + K K KT E+T
Sbjct: 1376 KEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQT 1411
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 59.3 bits (142), Expect = 1e-08
Identities = 118/544 (21%), Positives = 214/544 (39%), Gaps = 55/544 (10%)
Query: 4 PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAAS---LGSSQSSRT 60
PG+ +P + A A +T E+ SES S+ E S+E+ A+ L + S +T
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSE--ESSDSEEETPAAKALLQAKASGKT 368
Query: 61 YAGGTASA-TKVSASSGAT-SKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQA-VKTE 117
G ASA K S GA + P KA ++ + + +++A + +
Sbjct: 369 SQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAK 428
Query: 118 PEKKSQSTKPKSLP-KQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGE 176
P K+ + S P K++ G+ A +K +A+ Q ++ + ++ ++ + E
Sbjct: 429 PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES-DSDRE 487
Query: 177 SVAGITAISGKPGDKKKEKKSLTPAVPVESKP------DKPSGKSGMDAALDDLIDTLGG 230
++A + A KP K + K PA + P P GK G +
Sbjct: 488 ALAAMNAAQVKPLGKSPQVK---PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEED 544
Query: 231 PEETEEENTTYTGPEVSDPMSSTYIEELGK----REVTIPPKYRELLAKKEGITGPPADS 286
E + EE++ + EV ++ + LG + + P K +K G +
Sbjct: 545 SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGP---PQKAGPVAVQVKA 601
Query: 287 SKPI----GPDDAIDALSSDFTCGSPTAA-GKKTEKEESTEVLKAQSAGTVRSAAPPQEK 341
KP+ +++ D+ S+ + TAA K K T+ ++ T + P
Sbjct: 602 EKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRV 661
Query: 342 KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE------EKLEKCGED 395
+ + + + S ++ P D S +E D + K + + G+
Sbjct: 662 GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKG 721
Query: 396 DETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK 455
+ + +K + + P+LP K P + +++ E ED + SE E
Sbjct: 722 LQVKAASVPVKGSLGQGTAPVLP---GKTGP-TVTQVKAEKQEDSESSE--------EES 769
Query: 456 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTV--PDDAVEALADSLGKKEADPE 513
E AA+PA V +V +T + +A P+ KGT+ P V A A + K+ P
Sbjct: 770 DSEEAAASPAQVKTSVKKTQAKANPAAARAPSA-KGTISAPGKVVTAAAQA---KQRSPS 825
Query: 514 DGKP 517
KP
Sbjct: 826 KVKP 829
Score = 58.2 bits (139), Expect = 3e-08
Identities = 162/803 (20%), Positives = 273/803 (33%), Gaps = 122/803 (15%)
Query: 35 PSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAIPV 94
P+ P + G E+ + S SS+ S + G +V + + S N + K P
Sbjct: 531 PATPSAQVGKWEEDSES--SSEESSDSSDG-----EVPTAVAPAQEKSLGNILQAK--PT 581
Query: 95 SQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQ 154
S +GP +K AV+ + EK +++ +++SD S D+ A +A+
Sbjct: 582 SSPAKGP----PQKAGPVAVQVKAEKPMDNSESS---EESSD--SADSEEAPAAMTAAQA 632
Query: 155 QPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGK 214
+P+ K + K P+ + VA + + P +K+ T P S P G
Sbjct: 633 KPALKIPQTKACPKKTNTTASAKVAPVRVGTQAP------RKAGTATSPAGSSPAVAGGT 686
Query: 215 SGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPK------ 268
D+ E EE T G V+ + + + L + ++P K
Sbjct: 687 QRPAE------DSSSSEESDSEEEKT--GLAVTVGQAKSVGKGLQVKAASVPVKGSLGQG 738
Query: 269 YRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPT---AAGKKTEKEESTEVLK 325
+L K G T + K + + + S+ SP + KKT+ + + +
Sbjct: 739 TAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAAR 798
Query: 326 AQSA-GTVRS-----AAPPQEKKR---KVEKDTMSDQALEALS-------------ASLG 363
A SA GT+ + A Q K+R KV+ + Q L+ A+
Sbjct: 799 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 858
Query: 364 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 423
Q PE D S +E +++ + E L + +T L PA + K P P K
Sbjct: 859 QAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGK 918
Query: 424 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 483
P + K+ S + + +S APA V+ A Q
Sbjct: 919 TGPSAAQA-------------GKQDDSGSSSEESDSDGEAPAAVTSA---------QVIK 956
Query: 484 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 543
P P A A + + + P + + + E + E + + + P
Sbjct: 957 P-PLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTP 1015
Query: 544 DYRLEEVKDKDGKP-LLPKESKEQLPPMSEDFLL-DALSEDFSGPQ----NASSLKFEDA 597
R V P + PK S E + D ++ Q N +SL A
Sbjct: 1016 GIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQA 1075
Query: 598 KLAAAISEVV-SQTPASTTQAGA------------PPRDTSQSDKDLDDALDKLSDSLGQ 644
L + +Q P + TQ + P+ TS K + + Q
Sbjct: 1076 ALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQ 1135
Query: 645 RQPDPDENKPMEDKVKEKAKAEHRDK----------LGERDDTIPPEYRHLLDDNGQDKP 694
P+ + ED + +E + LG ++ +D
Sbjct: 1136 ATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDV 1195
Query: 695 VKPPTKKSEDSKKPA--DDQDPIDALSGDLDSCPSTTET----SQNTAKDKCK-KAASSS 747
V P P + LDS PS + T K + K + A+
Sbjct: 1196 VAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGM 1255
Query: 748 KAPKNGGKAKDSAKTTEETSKPK 770
+PK GGK S T +++ KPK
Sbjct: 1256 LSPKTGGKEAASGTTPQKSRKPK 1278
Score = 53.5 bits (127), Expect = 7e-07
Identities = 143/683 (20%), Positives = 226/683 (33%), Gaps = 108/683 (15%)
Query: 154 QQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSG 213
QQ SE + K + + A V+ + S + E++ A ++ P S
Sbjct: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTS-----ESSEEEEEAEAETAKATPRLAST 108
Query: 214 KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEEL--GK--REVTIPPKY 269
S + A DL ++ + E E TG + P + + L GK R+ P
Sbjct: 109 NSSVLGA--DLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSAN 166
Query: 270 RELLAKKEGITGPPA--DSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQ 327
L+++ E PA ++KP + A +D + +++ +T+ E V AQ
Sbjct: 167 TTLVSETEEEGSVPAFGAAAKP----GMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQ 222
Query: 328 SAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL--GTRQAEPELDLRSIKEVDEAKAK 385
+ S +K + D + +L R +PE + S +E E+
Sbjct: 223 VKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSES--- 279
Query: 386 EEKLEKCGEDDETIPSEYRLK------PATDKDGKPLLPEPEEKPKPRSESELIDELSED 439
E+ G + SE L+ PA GK P P K + + ED
Sbjct: 280 -EEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEED 338
Query: 440 FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 499
+ S E+ S E+T +KA A S +TS SAP + + KG P
Sbjct: 339 SESSS--EESSDSEEETPAAKALLQAKASG---KTSQVGAASAPAKESPRKGAAP----- 388
Query: 500 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEK---EETIP---------PDYRL 547
A P P + K + +EED + E+ EE P P R
Sbjct: 389 ----------APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA 438
Query: 548 EEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVV 607
K+ P++ PP + + SS + D+ A +
Sbjct: 439 ASAPAKES----PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNA 494
Query: 608 SQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEH 667
+Q P T A +G P K ED E + E
Sbjct: 495 AQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEED--SESSSEES 552
Query: 668 RDKL-GERDDTIPPEYRHLLDDNGQDKPVKPPTK-----------------------KSE 703
D GE + P L + Q KP P K SE
Sbjct: 553 SDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSE 612
Query: 704 DSKKPADDQDPIDALSG----------DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNG 753
+S AD ++ A++ +CP T T TA K ++AP+
Sbjct: 613 ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNT---TASAKVAPVRVGTQAPRKA 669
Query: 754 GKAKDSAKTTEE----TSKPKDD 772
G A A ++ T +P +D
Sbjct: 670 GTATSPAGSSPAVAGGTQRPAED 692
Score = 42.0 bits (97), Expect = 0.002
Identities = 158/880 (17%), Positives = 300/880 (34%), Gaps = 133/880 (15%)
Query: 1 MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
M+ KPA P+ A ++T+ S K + P + G + + K + + SS
Sbjct: 627 MTAAQAKPALKI-PQTKACPKKTNTTASAKVA--PVRVGTQ--APRKAGTATSPAGSSPA 681
Query: 61 YAGGTASATKVSASSGATSKSS-----SMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVK 115
AGGT + S+SS + ++ + K++ Q++ +P K +
Sbjct: 682 VAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAP 741
Query: 116 TEPEKKSQS-TKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKP------- 167
P K + T+ K+ ++ S++ ++ +++A + A+ + S K T+ K P
Sbjct: 742 VLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPS 801
Query: 168 -QDMISAGGESVAGI---------------------TAISGKPGDKKKEKKSLTPAVPVE 205
+ ISA G+ V T ++ P K++ A +
Sbjct: 802 AKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQ 861
Query: 206 SKPDKPSGKSGMDAALDDLIDTLGG----------------PEETEEENTTYTGPEVSDP 249
+ P++ SG S ++ ++ +TL +E+ + T P + P
Sbjct: 862 TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP 921
Query: 250 M---------SSTYIEE----------LGKREVTIPPKYRELLAKKEGITGPPADSSKPI 290
S + EE + +V PP + GP A ++
Sbjct: 922 SAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLI--FVDPNRSPAGPAATPAQAQ 979
Query: 291 GPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVL--------------------KAQSAG 330
A +S+ T S ++ + + +T+ L KA AG
Sbjct: 980 AASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAG 1039
Query: 331 TVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLE 390
S + K +++ + Q + ASL QA ++ + E A+ +
Sbjct: 1040 ASSSKESSRISDGK-KQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSS 1098
Query: 391 KCGEDDETIPSEYRLKPA-----TDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSEC 445
T+P+ + T+K KP LPE ++ K S D+ + D S
Sbjct: 1099 GVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESS---DDSEDSSDSSSG 1155
Query: 446 KEKPSKPTEKTEESKAAAPAP------VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 499
E+ + + + + P P V E +S + + P + L G +
Sbjct: 1156 SEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVA--PSQSLLSGYMTPGLTP 1213
Query: 500 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET---IPPDYRLEEVKDKDGK 556
A +S K D P + + D ++ + ++ + P +E
Sbjct: 1214 A--NSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTP 1271
Query: 557 PLLPKESKEQLPPMSEDFLLDA-LSEDFSG---PQNASSLKFEDAKLAAAISEVVSQTPA 612
K K P + L + +++ G P N + ++ K+ + E +
Sbjct: 1272 QKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVV 1331
Query: 613 STTQAGAPPRDTSQSDKDLDDA------LDKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 666
TT+ + S+ K D K LG + P + K KA+
Sbjct: 1332 DTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAK 1391
Query: 667 HRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCP 726
RDK D + + L G + +K + + D +P + S
Sbjct: 1392 -RDKAS--GDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNP-KSKKEKKKSDK 1447
Query: 727 STTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEET 766
+ + K K KKA++ + K K KT E+T
Sbjct: 1448 RKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQT 1487
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.299 0.120 0.322
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,221,210
Number of Sequences: 37866
Number of extensions: 1949962
Number of successful extensions: 14972
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 135
Number of HSP's successfully gapped in prelim test: 1085
Number of HSP's that attempted gapping in prelim test: 9450
Number of HSP's gapped (non-prelim): 4688
length of query: 772
length of database: 18,247,518
effective HSP length: 110
effective length of query: 662
effective length of database: 14,082,258
effective search space: 9322454796
effective search space used: 9322454796
T: 11
A: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.