Search of human proteins with 109637757

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|109637757 calpastatin isoform e [Homo sapiens]
         (756 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|109637757 calpastatin isoform e [Homo sapiens]                    1490   0.0  
gi|109637763 calpastatin isoform h [Homo sapiens]                    1481   0.0  
gi|109637753 calpastatin isoform a [Homo sapiens]                    1468   0.0  
gi|109637759 calpastatin isoform f [Homo sapiens]                    1431   0.0  
gi|109637761 calpastatin isoform g [Homo sapiens]                    1421   0.0  
gi|109637769 calpastatin isoform k [Homo sapiens]                    1333   0.0  
gi|27765085 calpastatin isoform b [Homo sapiens]                     1324   0.0  
gi|109637765 calpastatin isoform i [Homo sapiens]                    1311   0.0  
gi|109637771 calpastatin isoform l [Homo sapiens]                    1284   0.0  
gi|109637767 calpastatin isoform j [Homo sapiens]                    1274   0.0  
gi|27765087 calpastatin isoform c [Homo sapiens]                      781   0.0  
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     93   1e-18
gi|150170670 piccolo isoform 2 [Homo sapiens]                          75   2e-13
gi|150378539 piccolo isoform 1 [Homo sapiens]                          75   2e-13
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]                    69   1e-11
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    69   2e-11
gi|104526627 triadin [Homo sapiens]                                    68   4e-11
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    67   6e-11
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    67   6e-11
gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa...    67   8e-11
gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa...    67   8e-11
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    65   2e-10
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   63   1e-09
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   63   1e-09
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   63   1e-09
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    63   1e-09
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    63   1e-09
gi|109637791 transcription factor-like nuclear regulator [Homo s...    63   1e-09
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ...    62   2e-09
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    61   3e-09

>gi|109637757 calpastatin isoform e [Homo sapiens]
          Length = 756

 Score = 1490 bits (3858), Expect = 0.0
 Identities = 756/756 (100%), Positives = 756/756 (100%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
           YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120

Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
           HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA
Sbjct: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180

Query: 181 ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 240
           ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG
Sbjct: 181 ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 240

Query: 241 PEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTE 300
           PEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTE
Sbjct: 241 PEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTE 300

Query: 301 KEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSI 360
           KEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSI
Sbjct: 301 KEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSI 360

Query: 361 KEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDEL 420
           KEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDEL
Sbjct: 361 KEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDEL 420

Query: 421 SEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDD 480
           SEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDD
Sbjct: 421 SEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDD 480

Query: 481 AVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGK 540
           AVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGK
Sbjct: 481 AVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGK 540

Query: 541 PLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQ 600
           PLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQ
Sbjct: 541 PLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQ 600

Query: 601 AGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDD 660
           AGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDD
Sbjct: 601 AGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDD 660

Query: 661 TIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTA 720
           TIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTA
Sbjct: 661 TIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTA 720

Query: 721 KDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 756
           KDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 721 KDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 756


>gi|109637763 calpastatin isoform h [Homo sapiens]
          Length = 769

 Score = 1481 bits (3834), Expect = 0.0
 Identities = 756/769 (98%), Positives = 756/769 (98%), Gaps = 13/769 (1%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
           YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120

Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
           HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA
Sbjct: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180

Query: 181 ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 240
           ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG
Sbjct: 181 ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 240

Query: 241 PEVSDPMSSTYIEELGKREVTIPPKYRELLAK-------------PIGPDDAIDALSSDF 287
           PEVSDPMSSTYIEELGKREVTIPPKYRELLAK             PIGPDDAIDALSSDF
Sbjct: 241 PEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDF 300

Query: 288 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG 347
           TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG
Sbjct: 301 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG 360

Query: 348 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 407
           TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK
Sbjct: 361 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 420

Query: 408 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 467
           PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP
Sbjct: 421 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 480

Query: 468 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 527
           PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP
Sbjct: 481 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 540

Query: 528 DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 587
           DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI
Sbjct: 541 DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 600

Query: 588 SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA 647
           SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA
Sbjct: 601 SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA 660

Query: 648 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 707
           KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD
Sbjct: 661 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 720

Query: 708 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 756
           SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 721 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 769


>gi|109637753 calpastatin isoform a [Homo sapiens]
          Length = 791

 Score = 1468 bits (3801), Expect = 0.0
 Identities = 756/791 (95%), Positives = 756/791 (95%), Gaps = 35/791 (4%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 61  YAGGTASATKVSASSGATSKSSSMNPTETKA----------------------VKTEPEK 98
           YAGGTASATKVSASSGATSKSSSMNPTETKA                      VKTEPEK
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK 120

Query: 99  KSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKST 158
           KSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKST
Sbjct: 121 KSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKST 180

Query: 159 EPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAAL 218
           EPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAAL
Sbjct: 181 EPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAAL 240

Query: 219 DDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK------ 272
           DDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK      
Sbjct: 241 DDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITG 300

Query: 273 -------PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEK 325
                  PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEK
Sbjct: 301 PPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEK 360

Query: 326 KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPS 385
           KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPS
Sbjct: 361 KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPS 420

Query: 386 EYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKA 445
           EYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKA
Sbjct: 421 EYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKA 480

Query: 446 AAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK 505
           AAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK
Sbjct: 481 AAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK 540

Query: 506 VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE 565
           VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE
Sbjct: 541 VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE 600

Query: 566 DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDS 625
           DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDS
Sbjct: 601 DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDS 660

Query: 626 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK 685
           LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK
Sbjct: 661 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK 720

Query: 686 SEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAK 745
           SEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAK
Sbjct: 721 SEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAK 780

Query: 746 TTEETSKPKDD 756
           TTEETSKPKDD
Sbjct: 781 TTEETSKPKDD 791


>gi|109637759 calpastatin isoform f [Homo sapiens]
          Length = 750

 Score = 1431 bits (3705), Expect = 0.0
 Identities = 737/769 (95%), Positives = 737/769 (95%), Gaps = 32/769 (4%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
           YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTK                
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTK---------------- 104

Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
              PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA
Sbjct: 105 ---PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 161

Query: 181 ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 240
           ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG
Sbjct: 162 ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 221

Query: 241 PEVSDPMSSTYIEELGKREVTIPPKYRELLAK-------------PIGPDDAIDALSSDF 287
           PEVSDPMSSTYIEELGKREVTIPPKYRELLAK             PIGPDDAIDALSSDF
Sbjct: 222 PEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDF 281

Query: 288 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG 347
           TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG
Sbjct: 282 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG 341

Query: 348 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 407
           TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK
Sbjct: 342 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 401

Query: 408 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 467
           PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP
Sbjct: 402 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 461

Query: 468 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 527
           PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP
Sbjct: 462 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 521

Query: 528 DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 587
           DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI
Sbjct: 522 DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 581

Query: 588 SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA 647
           SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA
Sbjct: 582 SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA 641

Query: 648 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 707
           KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD
Sbjct: 642 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 701

Query: 708 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 756
           SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 702 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 750


>gi|109637761 calpastatin isoform g [Homo sapiens]
          Length = 772

 Score = 1421 bits (3679), Expect = 0.0
 Identities = 729/772 (94%), Positives = 737/772 (95%), Gaps = 16/772 (2%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEK---KSQEGK 117
           YAGGTASATKVSASSGATSKSSSMNPTETKA+    + +         H+K   K++  K
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK 120

Query: 118 PKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 177
             + T+PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG
Sbjct: 121 KSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 180

Query: 178 ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT 237
           ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT
Sbjct: 181 ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT 240

Query: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK-------------PIGPDDAIDALS 284
           YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK             PIGPDDAIDALS
Sbjct: 241 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS 300

Query: 285 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA 344
           SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA
Sbjct: 301 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA 360

Query: 345 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 404
           SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP
Sbjct: 361 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 420

Query: 405 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 464
           EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ
Sbjct: 421 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 480

Query: 465 SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET 524
           SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET
Sbjct: 481 SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET 540

Query: 525 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA 584
           IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA
Sbjct: 541 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA 600

Query: 585 AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK 644
           AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK
Sbjct: 601 AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK 660

Query: 645 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 704
           EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG
Sbjct: 661 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 720

Query: 705 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 756
           DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 721 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 772


>gi|109637769 calpastatin isoform k [Homo sapiens]
          Length = 673

 Score = 1333 bits (3451), Expect = 0.0
 Identities = 673/673 (100%), Positives = 673/673 (100%)

Query: 84  MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 143
           MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK
Sbjct: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60

Query: 144 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 203
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120

Query: 204 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 263
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180

Query: 264 PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 323
           PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ
Sbjct: 181 PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 240

Query: 324 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 383
           EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI
Sbjct: 241 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 300

Query: 384 PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES 443
           PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES
Sbjct: 301 PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES 360

Query: 444 KAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVM 503
           KAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVM
Sbjct: 361 KAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVM 420

Query: 504 DKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDAL 563
           DKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDAL
Sbjct: 421 DKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDAL 480

Query: 564 SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLS 623
           SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLS
Sbjct: 481 SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLS 540

Query: 624 DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT 683
           DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT
Sbjct: 541 DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT 600

Query: 684 KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDS 743
           KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDS
Sbjct: 601 KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDS 660

Query: 744 AKTTEETSKPKDD 756
           AKTTEETSKPKDD
Sbjct: 661 AKTTEETSKPKDD 673



 Score =  218 bits (555), Expect = 2e-56
 Identities = 194/659 (29%), Positives = 313/659 (47%), Gaps = 63/659 (9%)

Query: 3   QPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYA 62
           +P +       P++A+       H  +  S S  +   +K ++ K       S    + A
Sbjct: 34  KPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVA 93

Query: 63  GGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKL-SVVHEKKSQEGKPKEH 121
           G TA    +S   G   K    + T    V+++P+K S  + + + + +     G P+E 
Sbjct: 94  GITA----ISGKPG-DKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEET 148

Query: 122 TEPKS--LPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK-TKPQDMISA-GGESVAG 177
            E  +     + SD  S+  + ++   R     P  +    K   P D I A   +   G
Sbjct: 149 EEENTTYTGPEVSDPMSS-TYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCG 207

Query: 178 ITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPE 229
               +GK  +K++  +        ++  A P + K  K    +  D AL+ L  +L G  
Sbjct: 208 SPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL-GTR 266

Query: 230 ETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR----------------ELLAK 272
           + E E    +  EV +  +    +E+ G+ + TIP +YR                E   K
Sbjct: 267 QAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPK 326

Query: 273 PIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLKAQSAGTVRSAAPP 322
           P    + ID LS DF        P+   +KTE+ ++      +E +   S  +++SA P 
Sbjct: 327 PRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP- 385

Query: 323 QEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDET 382
              +    K T+ D A+EAL+ SLG ++A+PE D + + +  + KAKEE  EK GE +ET
Sbjct: 386 ---EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEET 441

Query: 383 IPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE 441
           IP +YRL+   DKDGKPLLP E +E+  P SE  L+D LSEDF   +     +  + K E
Sbjct: 442 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFE 496

Query: 442 ESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEADPEDGK 500
           ++K A  A +SE V +T   + Q+ APP   +      DDA++ L+DSLG+++ DP++ K
Sbjct: 497 DAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENK 554

Query: 501 PVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDF 558
           P+ DKVKEKAK E R+KLGE+++TIPP+YR     +   KP+ P  K+S++   P  +  
Sbjct: 555 PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 614

Query: 559 LLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 617
            +DALS D     + +      AK     +   S+ P +  +A    + T ++ K  DD
Sbjct: 615 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 673



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 83/359 (23%), Positives = 142/359 (39%), Gaps = 30/359 (8%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 318 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 375

Query: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
                 SA    A+   T    ++        K E + +     +  V EK  +E + K 
Sbjct: 376 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 435

Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
             + +++P         D   K  + + +++Q    S +          +G ++ + +  
Sbjct: 436 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 495

Query: 181 ISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEENTT 237
              K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +EN  
Sbjct: 496 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKP 555

Query: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELL-------------------AKPIGPDD 278
               +V +   + + ++LG+R+ TIPP+YR LL                    KP    D
Sbjct: 556 ME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 614

Query: 279 AIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 332
            IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K + D
Sbjct: 615 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 673


>gi|27765085 calpastatin isoform b [Homo sapiens]
          Length = 686

 Score = 1324 bits (3427), Expect = 0.0
 Identities = 673/686 (98%), Positives = 673/686 (98%), Gaps = 13/686 (1%)

Query: 84  MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 143
           MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK
Sbjct: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60

Query: 144 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 203
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120

Query: 204 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 263
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180

Query: 264 PKYRELLAK-------------PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 310
           PKYRELLAK             PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 181 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 240

Query: 311 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 370
           QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 241 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 300

Query: 371 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 430
           EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 301 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 360

Query: 431 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 490
           EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 361 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 420

Query: 491 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 550
           KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 421 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 480

Query: 551 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 610
           LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 481 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 540

Query: 611 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 670
           SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 541 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 600

Query: 671 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 730
           DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 601 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 660

Query: 731 SKAPKNGGKAKDSAKTTEETSKPKDD 756
           SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 661 SKAPKNGGKAKDSAKTTEETSKPKDD 686



 Score =  216 bits (550), Expect = 6e-56
 Identities = 194/672 (28%), Positives = 316/672 (47%), Gaps = 76/672 (11%)

Query: 3   QPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYA 62
           +P +       P++A+       H  +  S S  +   +K ++ K       S    + A
Sbjct: 34  KPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVA 93

Query: 63  GGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKL-SVVHEKKSQEGKPKE- 120
           G TA    +S   G   K    + T    V+++P+K S  + + + + +     G P+E 
Sbjct: 94  GITA----ISGKPG-DKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEET 148

Query: 121 ------HTEPKSLPKQAS----DTGSNDA-----HNKKAVSRSAEQQPSEKSTEPKTKPQ 165
                 +T P+     +S    + G  +      + +    +     P   S++P   P 
Sbjct: 149 EEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP-IGPD 207

Query: 166 DMISA-GGESVAGITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDA 216
           D I A   +   G    +GK  +K++  +        ++  A P + K  K    +  D 
Sbjct: 208 DAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQ 267

Query: 217 ALDDLIDTLGGPEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR-------- 267
           AL+ L  +L G  + E E    +  EV +  +    +E+ G+ + TIP +YR        
Sbjct: 268 ALEALSASL-GTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKD 326

Query: 268 --------ELLAKPIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLK 309
                   E   KP    + ID LS DF        P+   +KTE+ ++      +E + 
Sbjct: 327 GKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVC 386

Query: 310 AQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAK 369
             S  +++SA P    +    K T+ D A+EAL+ SLG ++A+PE D + + +  + KAK
Sbjct: 387 RTSMCSIQSAPP----EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAK 441

Query: 370 EEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSE 428
           EE  EK GE +ETIP +YRL+   DKDGKPLLP E +E+  P SE  L+D LSEDF   +
Sbjct: 442 EEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ 501

Query: 429 CKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALAD 487
                +  + K E++K A  A +SE V +T   + Q+ APP   +      DDA++ L+D
Sbjct: 502 -----NASSLKFEDAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSD 554

Query: 488 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--K 545
           SLG+++ DP++ KP+ DKVKEKAK E R+KLGE+++TIPP+YR     +   KP+ P  K
Sbjct: 555 SLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTK 614

Query: 546 ESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPP 605
           +S++   P  +   +DALS D     + +      AK     +   S+ P +  +A    
Sbjct: 615 KSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSA 674

Query: 606 RDTSQSDKDLDD 617
           + T ++ K  DD
Sbjct: 675 KTTEETSKPKDD 686



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 83/359 (23%), Positives = 142/359 (39%), Gaps = 30/359 (8%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 331 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 388

Query: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
                 SA    A+   T    ++        K E + +     +  V EK  +E + K 
Sbjct: 389 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 448

Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
             + +++P         D   K  + + +++Q    S +          +G ++ + +  
Sbjct: 449 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 508

Query: 181 ISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEENTT 237
              K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +EN  
Sbjct: 509 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKP 568

Query: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELL-------------------AKPIGPDD 278
               +V +   + + ++LG+R+ TIPP+YR LL                    KP    D
Sbjct: 569 ME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 627

Query: 279 AIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 332
            IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K + D
Sbjct: 628 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 686


>gi|109637765 calpastatin isoform i [Homo sapiens]
          Length = 708

 Score = 1311 bits (3394), Expect = 0.0
 Identities = 673/708 (95%), Positives = 673/708 (95%), Gaps = 35/708 (4%)

Query: 84  MNPTETKA----------------------VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 121
           MNPTETKA                      VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH
Sbjct: 1   MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60

Query: 122 TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 181
           TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 61  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 120

Query: 182 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 241
           SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 121 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180

Query: 242 EVSDPMSSTYIEELGKREVTIPPKYRELLAK-------------PIGPDDAIDALSSDFT 288
           EVSDPMSSTYIEELGKREVTIPPKYRELLAK             PIGPDDAIDALSSDFT
Sbjct: 181 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240

Query: 289 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 348
           CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 241 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300

Query: 349 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 408
           RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 301 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360

Query: 409 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 468
           KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 361 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420

Query: 469 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 528
           EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 421 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480

Query: 529 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 588
           YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 481 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 540

Query: 589 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 648
           EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 541 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 600

Query: 649 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 708
           AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 601 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660

Query: 709 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 756
           CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 661 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708



 Score =  216 bits (550), Expect = 6e-56
 Identities = 194/672 (28%), Positives = 316/672 (47%), Gaps = 76/672 (11%)

Query: 3   QPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYA 62
           +P +       P++A+       H  +  S S  +   +K ++ K       S    + A
Sbjct: 56  KPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVA 115

Query: 63  GGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKL-SVVHEKKSQEGKPKE- 120
           G TA    +S   G   K    + T    V+++P+K S  + + + + +     G P+E 
Sbjct: 116 GITA----ISGKPG-DKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEET 170

Query: 121 ------HTEPKSLPKQAS----DTGSNDA-----HNKKAVSRSAEQQPSEKSTEPKTKPQ 165
                 +T P+     +S    + G  +      + +    +     P   S++P   P 
Sbjct: 171 EEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP-IGPD 229

Query: 166 DMISA-GGESVAGITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDA 216
           D I A   +   G    +GK  +K++  +        ++  A P + K  K    +  D 
Sbjct: 230 DAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQ 289

Query: 217 ALDDLIDTLGGPEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR-------- 267
           AL+ L  +L G  + E E    +  EV +  +    +E+ G+ + TIP +YR        
Sbjct: 290 ALEALSASL-GTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKD 348

Query: 268 --------ELLAKPIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLK 309
                   E   KP    + ID LS DF        P+   +KTE+ ++      +E + 
Sbjct: 349 GKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVC 408

Query: 310 AQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAK 369
             S  +++SA P    +    K T+ D A+EAL+ SLG ++A+PE D + + +  + KAK
Sbjct: 409 RTSMCSIQSAPP----EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAK 463

Query: 370 EEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSE 428
           EE  EK GE +ETIP +YRL+   DKDGKPLLP E +E+  P SE  L+D LSEDF   +
Sbjct: 464 EEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ 523

Query: 429 CKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALAD 487
                +  + K E++K A  A +SE V +T   + Q+ APP   +      DDA++ L+D
Sbjct: 524 -----NASSLKFEDAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSD 576

Query: 488 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--K 545
           SLG+++ DP++ KP+ DKVKEKAK E R+KLGE+++TIPP+YR     +   KP+ P  K
Sbjct: 577 SLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTK 636

Query: 546 ESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPP 605
           +S++   P  +   +DALS D     + +      AK     +   S+ P +  +A    
Sbjct: 637 KSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSA 696

Query: 606 RDTSQSDKDLDD 617
           + T ++ K  DD
Sbjct: 697 KTTEETSKPKDD 708



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 83/359 (23%), Positives = 142/359 (39%), Gaps = 30/359 (8%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 353 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 410

Query: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
                 SA    A+   T    ++        K E + +     +  V EK  +E + K 
Sbjct: 411 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 470

Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
             + +++P         D   K  + + +++Q    S +          +G ++ + +  
Sbjct: 471 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 530

Query: 181 ISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEENTT 237
              K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +EN  
Sbjct: 531 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKP 590

Query: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELL-------------------AKPIGPDD 278
               +V +   + + ++LG+R+ TIPP+YR LL                    KP    D
Sbjct: 591 ME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 649

Query: 279 AIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 332
            IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K + D
Sbjct: 650 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708


>gi|109637771 calpastatin isoform l [Homo sapiens]
          Length = 654

 Score = 1284 bits (3322), Expect = 0.0
 Identities = 654/673 (97%), Positives = 654/673 (97%), Gaps = 19/673 (2%)

Query: 84  MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 143
           MNPTETKAVKTEPEKKSQSTK                   PKSLPKQASDTGSNDAHNKK
Sbjct: 1   MNPTETKAVKTEPEKKSQSTK-------------------PKSLPKQASDTGSNDAHNKK 41

Query: 144 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 203
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 42  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 101

Query: 204 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 263
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 102 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 161

Query: 264 PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 323
           PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ
Sbjct: 162 PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 221

Query: 324 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 383
           EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI
Sbjct: 222 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 281

Query: 384 PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES 443
           PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES
Sbjct: 282 PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES 341

Query: 444 KAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVM 503
           KAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVM
Sbjct: 342 KAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVM 401

Query: 504 DKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDAL 563
           DKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDAL
Sbjct: 402 DKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDAL 461

Query: 564 SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLS 623
           SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLS
Sbjct: 462 SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLS 521

Query: 624 DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT 683
           DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT
Sbjct: 522 DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT 581

Query: 684 KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDS 743
           KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDS
Sbjct: 582 KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDS 641

Query: 744 AKTTEETSKPKDD 756
           AKTTEETSKPKDD
Sbjct: 642 AKTTEETSKPKDD 654



 Score =  218 bits (554), Expect = 2e-56
 Identities = 193/648 (29%), Positives = 310/648 (47%), Gaps = 63/648 (9%)

Query: 14  PRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSA 73
           P++A+       H  +  S S  +   +K ++ K       S    + AG TA    +S 
Sbjct: 26  PKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA----ISG 81

Query: 74  SSGATSKSSSMNPTETKAVKTEPEKKSQSTKL-SVVHEKKSQEGKPKEHTEPKS--LPKQ 130
             G   K    + T    V+++P+K S  + + + + +     G P+E  E  +     +
Sbjct: 82  KPG-DKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPE 140

Query: 131 ASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK-TKPQDMISA-GGESVAGITAISGKPGDK 188
            SD  S+  + ++   R     P  +    K   P D I A   +   G    +GK  +K
Sbjct: 141 VSDPMSS-TYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEK 199

Query: 189 KKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 240
           ++  +        ++  A P + K  K    +  D AL+ L  +L G  + E E    + 
Sbjct: 200 EESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL-GTRQAEPELDLRSI 258

Query: 241 PEVSDPMS-STYIEELGKREVTIPPKYR----------------ELLAKPIGPDDAIDAL 283
            EV +  +    +E+ G+ + TIP +YR                E   KP    + ID L
Sbjct: 259 KEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDEL 318

Query: 284 SSDFTCG----SPTAAGKKTEKEES------TEVLKAQSAGTVRSAAPPQEKKRKVEKDT 333
           S DF        P+   +KTE+ ++      +E +   S  +++SA P    +    K T
Sbjct: 319 SEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP----EPATLKGT 374

Query: 334 MSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPAT 393
           + D A+EAL+ SLG ++A+PE D + + +  + KAKEE  EK GE +ETIP +YRL+   
Sbjct: 375 VPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVK 433

Query: 394 DKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVS 452
           DKDGKPLLP E +E+  P SE  L+D LSEDF   +     +  + K E++K A  A +S
Sbjct: 434 DKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA--AAIS 486

Query: 453 EAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAK 511
           E V +T   + Q+ APP   +      DDA++ L+DSLG+++ DP++ KP+ DKVKEKAK
Sbjct: 487 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 546

Query: 512 EEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSEDFSG 569
            E R+KLGE+++TIPP+YR     +   KP+ P  K+S++   P  +   +DALS D   
Sbjct: 547 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 606

Query: 570 PQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 617
             + +      AK     +   S+ P +  +A    + T ++ K  DD
Sbjct: 607 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 654



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 83/359 (23%), Positives = 142/359 (39%), Gaps = 30/359 (8%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 299 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 356

Query: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
                 SA    A+   T    ++        K E + +     +  V EK  +E + K 
Sbjct: 357 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 416

Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
             + +++P         D   K  + + +++Q    S +          +G ++ + +  
Sbjct: 417 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 476

Query: 181 ISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEENTT 237
              K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +EN  
Sbjct: 477 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKP 536

Query: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELL-------------------AKPIGPDD 278
               +V +   + + ++LG+R+ TIPP+YR LL                    KP    D
Sbjct: 537 ME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 595

Query: 279 AIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 332
            IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K + D
Sbjct: 596 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 654


>gi|109637767 calpastatin isoform j [Homo sapiens]
          Length = 667

 Score = 1275 bits (3298), Expect = 0.0
 Identities = 654/686 (95%), Positives = 654/686 (95%), Gaps = 32/686 (4%)

Query: 84  MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 143
           MNPTETKAVKTEPEKKSQSTK                   PKSLPKQASDTGSNDAHNKK
Sbjct: 1   MNPTETKAVKTEPEKKSQSTK-------------------PKSLPKQASDTGSNDAHNKK 41

Query: 144 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 203
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 42  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 101

Query: 204 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 263
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 102 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 161

Query: 264 PKYRELLAK-------------PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 310
           PKYRELLAK             PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 162 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 221

Query: 311 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 370
           QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 222 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 281

Query: 371 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 430
           EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 282 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 341

Query: 431 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 490
           EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 342 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 401

Query: 491 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 550
           KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 402 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 461

Query: 551 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 610
           LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 462 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 521

Query: 611 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 670
           SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 522 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 581

Query: 671 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 730
           DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 582 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 641

Query: 731 SKAPKNGGKAKDSAKTTEETSKPKDD 756
           SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 642 SKAPKNGGKAKDSAKTTEETSKPKDD 667



 Score =  216 bits (549), Expect = 8e-56
 Identities = 193/661 (29%), Positives = 313/661 (47%), Gaps = 76/661 (11%)

Query: 14  PRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSA 73
           P++A+       H  +  S S  +   +K ++ K       S    + AG TA    +S 
Sbjct: 26  PKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA----ISG 81

Query: 74  SSGATSKSSSMNPTETKAVKTEPEKKSQSTKL-SVVHEKKSQEGKPKE-------HTEPK 125
             G   K    + T    V+++P+K S  + + + + +     G P+E       +T P+
Sbjct: 82  KPG-DKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPE 140

Query: 126 SLPKQAS----DTGSNDA-----HNKKAVSRSAEQQPSEKSTEPKTKPQDMISA-GGESV 175
                +S    + G  +      + +    +     P   S++P   P D I A   +  
Sbjct: 141 VSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP-IGPDDAIDALSSDFT 199

Query: 176 AGITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGG 227
            G    +GK  +K++  +        ++  A P + K  K    +  D AL+ L  +L G
Sbjct: 200 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL-G 258

Query: 228 PEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR----------------ELL 270
             + E E    +  EV +  +    +E+ G+ + TIP +YR                E  
Sbjct: 259 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 318

Query: 271 AKPIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLKAQSAGTVRSAA 320
            KP    + ID LS DF        P+   +KTE+ ++      +E +   S  +++SA 
Sbjct: 319 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 378

Query: 321 PPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDD 380
           P    +    K T+ D A+EAL+ SLG ++A+PE D + + +  + KAKEE  EK GE +
Sbjct: 379 P----EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKE 433

Query: 381 ETIPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK 439
           ETIP +YRL+   DKDGKPLLP E +E+  P SE  L+D LSEDF   +     +  + K
Sbjct: 434 ETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLK 488

Query: 440 TEESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEADPED 498
            E++K A  A +SE V +T   + Q+ APP   +      DDA++ L+DSLG+++ DP++
Sbjct: 489 FEDAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDE 546

Query: 499 GKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSE 556
            KP+ DKVKEKAK E R+KLGE+++TIPP+YR     +   KP+ P  K+S++   P  +
Sbjct: 547 NKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADD 606

Query: 557 DFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLD 616
              +DALS D     + +      AK     +   S+ P +  +A    + T ++ K  D
Sbjct: 607 QDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKD 666

Query: 617 D 617
           D
Sbjct: 667 D 667



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 83/359 (23%), Positives = 142/359 (39%), Gaps = 30/359 (8%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 312 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 369

Query: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
                 SA    A+   T    ++        K E + +     +  V EK  +E + K 
Sbjct: 370 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 429

Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
             + +++P         D   K  + + +++Q    S +          +G ++ + +  
Sbjct: 430 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 489

Query: 181 ISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEENTT 237
              K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +EN  
Sbjct: 490 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKP 549

Query: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELL-------------------AKPIGPDD 278
               +V +   + + ++LG+R+ TIPP+YR LL                    KP    D
Sbjct: 550 ME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 608

Query: 279 AIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 332
            IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K + D
Sbjct: 609 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 667


>gi|27765087 calpastatin isoform c [Homo sapiens]
          Length = 430

 Score =  781 bits (2017), Expect = 0.0
 Identities = 391/393 (99%), Positives = 392/393 (99%), Gaps = 1/393 (0%)

Query: 364 DEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 423
           D+AKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED
Sbjct: 39  DQAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 98

Query: 424 FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 483
           FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE
Sbjct: 99  FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 158

Query: 484 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 543
           ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL
Sbjct: 159 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 218

Query: 544 PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA 603
           PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA
Sbjct: 219 PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA 278

Query: 604 PPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP 663
           PPRDTS SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP
Sbjct: 279 PPRDTS-SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP 337

Query: 664 PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK 723
           PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK
Sbjct: 338 PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK 397

Query: 724 CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 756
           CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 398 CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 430



 Score =  200 bits (508), Expect = 5e-51
 Identities = 142/396 (35%), Positives = 207/396 (52%), Gaps = 43/396 (10%)

Query: 252 IEELGKREVTIPPKYR----------------ELLAKPIGPDDAIDALSSDFTCGSPTAA 295
           +E+ G+ + TIP +YR                E   KP    + ID LS DF        
Sbjct: 48  LEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSE--CK 105

Query: 296 GKKTEKEESTEVLKAQSAGTVRSA-----------APPQEKKRKVEKDTMSDQALEALSA 344
            K ++  E TE  KA +   V  A           APP+    K    T+ D A+EAL+ 
Sbjct: 106 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLK---GTVPDDAVEALAD 162

Query: 345 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP-E 403
           SLG ++A+PE D + + +  + KAKEE  EK GE +ETIP +YRL+   DKDGKPLLP E
Sbjct: 163 SLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE 221

Query: 404 PEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSI 463
            +E+  P SE  L+D LSEDF   +     +  + K E++K A  A +SE V +T   + 
Sbjct: 222 SKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA--AAISEVVSQTPASTT 274

Query: 464 QSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEE 523
           Q+  P   T      DDA++ L+DSLG+++ DP++ KP+ DKVKEKAK E R+KLGE+++
Sbjct: 275 QAGAPPRDTSSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDD 334

Query: 524 TIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDA 581
           TIPP+YR     +   KP+ P  K+S++   P  +   +DALS D     + +      A
Sbjct: 335 TIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTA 394

Query: 582 KLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 617
           K     +   S+ P +  +A    + T ++ K  DD
Sbjct: 395 KDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 430



 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 83/358 (23%), Positives = 139/358 (38%), Gaps = 29/358 (8%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 76  LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 133

Query: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120
                 SA    A+   T    ++        K E + +     +  V EK  +E + K 
Sbjct: 134 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 193

Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
             + +++P         D   K  + + +++Q    S +          +G ++ + +  
Sbjct: 194 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 253

Query: 181 ISGKPGDKKKEKKSLTPAVPVE--SKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTY 238
              K      E  S TPA   +  + P   S    +D ALD L D+LG  +   +EN   
Sbjct: 254 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSSDKDLDDALDKLSDSLGQRQPDPDENKPM 313

Query: 239 TGPEVSDPMSSTYIEELGKREVTIPPKYRELL-------------------AKPIGPDDA 279
              +V +   + + ++LG+R+ TIPP+YR LL                    KP    D 
Sbjct: 314 E-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDP 372

Query: 280 IDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 332
           IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K + D
Sbjct: 373 IDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 430


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 120/550 (21%), Positives = 217/550 (39%), Gaps = 46/550 (8%)

Query: 23  THEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSS 82
           T E   E+  E+  + G+++   E++ A  G  ++    A   AS  K + S     K  
Sbjct: 467 TEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSP---VKEE 523

Query: 83  SMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNK 142
           + +P E K+ + E E KS +   S    K   + + K   E KS  K+ + + +     +
Sbjct: 524 AKSPAEAKSPEKE-EAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPE 582

Query: 143 KAVSRSAEQ--QPSEKSTEPKTKP--QDMISAGGESVAGITAISGKPGDKKKEKKSLTPA 198
           KA S + E+   P+E  +  K K   ++   +  E+ + +   +  P + K  +K+ +P 
Sbjct: 583 KAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPT 642

Query: 199 VPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKR 258
                 P+K       +A   +   +    E    E      P  ++  S    +   K 
Sbjct: 643 KEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAK--SPVKAEAKSPEKAKSPVKE 700

Query: 259 EVTIPPKYRELLAKPI-GPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVR 317
           E   P K +  + +    P+ A   +  +        +  K E +   +    + A T+ 
Sbjct: 701 EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLD 760

Query: 318 SAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCG 377
             +P  +   K E  + +D+  E   + +      PE     +KE  +AKA E+++ K  
Sbjct: 761 VKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKE--DAKAPEKEIPKKE 818

Query: 378 E-----DDETIPSEYRLKPATDK---DGKPLLPEPEEKPKPRSESELIDELSEDFDRSEC 429
           E      +E  P E ++K    K   +  P  P+ EEK   + E    +   ++  + + 
Sbjct: 819 EVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKE----EAPKKEAPKPKV 874

Query: 430 KEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSL 489
           +EK     EK +ESK                     A  E A  K  VP    EA A   
Sbjct: 875 EEKKEPAVEKPKESKV-------------------EAKKEEAEDKKKVPTPEKEAPAKVE 915

Query: 490 GKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIP--PDYRLEEVKDKDGKPLLPKES 547
            K++A P++   V  K  + AK ++  K  EK+E  P   D + E+ K  + KP    ++
Sbjct: 916 VKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKA 975

Query: 548 KEQLPPMSED 557
           KE    +S++
Sbjct: 976 KEDDKTLSKE 985



 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 136/590 (23%), Positives = 221/590 (37%), Gaps = 58/590 (9%)

Query: 197 PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELG 256
           P +P  S   K   +  +        +T+   E+TEE   T    EV++       EE G
Sbjct: 427 PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVT---EEVTEEEEKEAKEEEG 483

Query: 257 KREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPT-------AAGKKTEKEESTEVLK 309
           K E     +  E   +      A +A S +    SP        A  K  EKEE+    +
Sbjct: 484 KEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAE 543

Query: 310 AQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAK 369
            +S    +S A  + K     K    ++A          +   P  +    K   EAK+ 
Sbjct: 544 VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKE--EAKSPAEAKSP 601

Query: 370 EEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSEC 429
           E+      E+ ++ P+E +     +      +  PE+   P  E     E ++  ++ E 
Sbjct: 602 EKAKSPVKEEAKS-PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEA 660

Query: 430 K--EKPSKPTEKTEESKAAAPAPV-SEAVCRTSMCS-IQSAPPEPATLKGTVPDDAVEA- 484
           K  EK   P +   +S   A +PV +EA       S ++     P   K  V ++A    
Sbjct: 661 KSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE 720

Query: 485 LADSLGKKEAD-PEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 543
            A S  K+EA  PE  K     VKE+AK  ++ K  EK +T+       +VK  + K   
Sbjct: 721 KAKSPVKEEAKTPEKAK---SPVKEEAKSPEKAKSPEKAKTL-------DVKSPEAKTPA 770

Query: 544 PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAA--------AISEVVSQTP 595
            +E++       E      + E+   P+ A S   EDAK             S V  +  
Sbjct: 771 KEEARSPADKFPEK-AKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK 829

Query: 596 ASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA-------K 648
               +   PP+   +         ++  DS  +  P  +  KP  ++ KE A       K
Sbjct: 830 PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESK 889

Query: 649 AEHRDKLGERDDTIP-PEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD--DQDPIDALSGD 705
            E + +  E    +P PE         ++ P K   K+    K+  +   ++P DA + +
Sbjct: 890 VEAKKEEAEDKKKVPTPE---------KEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKE 940

Query: 706 LDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKT-TEETSKPK 754
                   E +      K +KA    + PK   KAK+  KT ++E SKPK
Sbjct: 941 PSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPK 990



 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 141/628 (22%), Positives = 239/628 (38%), Gaps = 68/628 (10%)

Query: 86   PTETKAVKTEPEKK----SQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHN 141
            P+ +  +K + E+K     +S K +V+ E++++E +  E    +   +   + G  +   
Sbjct: 430  PSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGG 489

Query: 142  KKAVSRSAEQQ----PSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTP 197
            ++  +   E++    P+E++  P+ + +  +    +S A       K  +K++ K     
Sbjct: 490  EEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPA-----EAKSPEKEEAKSPAEV 544

Query: 198  AVPVESK-PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELG 256
              P ++K P K   KS  +A   +  +     E    E       E +   +     E  
Sbjct: 545  KSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKA 604

Query: 257  KREVTIPPKYRELLAKPIGPDDAIDA-LSSDFTCGSPTAA-GKKTEKEESTEVLKAQSAG 314
            K  V    K       P+  +    A + S     SPT    K  EK +S E  +A+S  
Sbjct: 605  KSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE 664

Query: 315  TVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA--EPELDLRSIKEVDEAKAKEEK 372
              +S    + K  +  K  +  +A     A    ++    PE     +KE  EAK+ E+ 
Sbjct: 665  KAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKE--EAKSPEKA 722

Query: 373  LEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEK 432
                 E+ +T   E    P  ++   P      EK K   +++ +D  S +  ++  KE+
Sbjct: 723  KSPVKEEAKT--PEKAKSPVKEEAKSP------EKAKSPEKAKTLDVKSPEA-KTPAKEE 773

Query: 433  PSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKK 492
               P +K  E    A +PV E V              P   K  + +DA +A    + KK
Sbjct: 774  ARSPADKFPEK---AKSPVKEEV------------KSPEKAKSPLKEDA-KAPEKEIPKK 817

Query: 493  EADP----EDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESK 548
            E       E+ KP   KVKE  K+ + EK        P   + EE KD   K   PK  K
Sbjct: 818  EEVKSPVKEEEKPQEVKVKEPPKKAEEEKA-------PATPKTEEKKDSK-KEEAPK--K 867

Query: 549  EQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT 608
            E   P  E+    A+ +       A   + ED K      E  +       +   P   T
Sbjct: 868  EAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPT-PEKEAPAKVEVKEDAKPKEKT 926

Query: 609  SQSDKDLDDALDKLSDSLGQRQPDPDENKPM--------EDKVKEKAKAEHRDKLGERDD 660
              + K+ DDA  K      +++    E K          E+K K +AKA+  DK   ++ 
Sbjct: 927  EVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEP 986

Query: 661  TIPPEYRHLLDDNGQDKPVKPPTKKSED 688
            + P   +     +   K  KPP K +ED
Sbjct: 987  SKPKAEKAEKSSSTDQKDSKPPEKATED 1014



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 110/473 (23%), Positives = 188/473 (39%), Gaps = 46/473 (9%)

Query: 308 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 367
           +K +S   ++     +++   VE+ T   Q  E ++        E E       E +EA+
Sbjct: 436 IKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAE 495

Query: 368 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 427
             EE+ +    ++   P +    P  ++   P   +  EK + +S +E+    S +  +S
Sbjct: 496 GGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV---KSPEKAKS 552

Query: 428 ECKEKPSKPTE--KTEESKAAAPAPVSEAVCRTSMCSIQSAPP----EPATLKGTVPDDA 481
             KE+   P E    E+ +A +PA V       S    ++  P     P   K  V ++A
Sbjct: 553 PAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEA 612

Query: 482 VE-ALADSLGKKEA-------DPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEE 533
              A A S  K+EA        PE  K      KE+AK  ++ K  EKEE   P+     
Sbjct: 613 KSPAEAKSPVKEEAKSPAEVKSPEKAK---SPTKEEAKSPEKAKSPEKEEAKSPEKAKSP 669

Query: 534 VKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQ 593
           VK +   P   K S  +    S +     + E+   P+ A S   E+AK        V +
Sbjct: 670 VKAEAKSPEKAK-SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728

Query: 594 TPASTTQAGAPPRDTSQSD---------KDLDDALDKLSDSLGQRQPDPDENKPMEDK-- 642
              +  +A +P ++ ++S          K LD    +      +    P +  P + K  
Sbjct: 729 EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSP 788

Query: 643 VKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDAL 702
           VKE+ K+  + K   ++D   PE      +  + + VK P K+ E  ++    + P  A 
Sbjct: 789 VKEEVKSPEKAKSPLKEDAKAPE-----KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKA- 842

Query: 703 SGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKD 755
             + +  P+T +T +   KD  K+ A   +AP    K K   K      KPK+
Sbjct: 843 --EEEKAPATPKTEEK--KDSKKEEAPKKEAP----KPKVEEKKEPAVEKPKE 887



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 101/473 (21%), Positives = 183/473 (38%), Gaps = 52/473 (10%)

Query: 4    PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAG 63
            P ++ A SP   ++    ++      K+      P + K   +++A S   ++S      
Sbjct: 567  PEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEA 626

Query: 64   GTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQE-GKPKEHT 122
             + +  K    + + +K  + +P + K+ + E  K  +  K  V  E KS E  K     
Sbjct: 627  KSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKA 686

Query: 123  EPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAIS 182
            E KS  K  S         +KA S   E+  S +  +   K +       +S     A S
Sbjct: 687  EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKS 746

Query: 183  GKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDA----ALDDLIDTLGGPEETE---EEN 235
             +     ++ K+L    P    P K   +S  D     A   + + +  PE+ +   +E+
Sbjct: 747  PEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKED 806

Query: 236  TTYTGPEV--SDPMSSTYIEELGKREVTI--PPKYRELLAKPIGPDDAIDALSSDFTCGS 291
                  E+   + + S   EE   +EV +  PPK  E    P                 +
Sbjct: 807  AKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAP----------------AT 850

Query: 292  PTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA 351
            P    KK  K+E     +A          P  EK ++ + +   ++A +        ++A
Sbjct: 851  PKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEA 910

Query: 352  EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKP--------LLPE 403
              +++++     ++AK KE K E   ++ +   ++   KPA  K+  P           +
Sbjct: 911  PAKVEVK-----EDAKPKE-KTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKK 964

Query: 404  PEEKPKPRSESELIDE-LSEDFDR---------SECKEKPSKPTEKTEESKAA 446
            PEEKPK  ++++  D+ LS++  +         S   +K SKP EK  E KAA
Sbjct: 965  PEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAA 1017



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 59/270 (21%), Positives = 103/270 (38%), Gaps = 46/270 (17%)

Query: 498 DGKPVMDKVKE--KAKEEDREKLGEK--------EETIPPDYRLEEVKDKDGKPLLPKES 547
           +G P +  V    K K E++ K+ EK        EE        EEV +++ K    +E 
Sbjct: 424 EGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEG 483

Query: 548 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 607
           KE+     E        E   G +   S   E+A              +   +A +P ++
Sbjct: 484 KEEEGGEEE--------EAEGGEEETKSPPAEEAA-------------SPEKEAKSPVKE 522

Query: 608 TSQSDKDLDDALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEY 666
            ++S  +              + P+ +E K P E K  EKAK+  +++     +   PE 
Sbjct: 523 EAKSPAEA-------------KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK 569

Query: 667 RHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKK 726
                      P K  +   E++K PA+ + P  A S   +   S  E +++  K++ K 
Sbjct: 570 EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAE-AKSPVKEEAKS 628

Query: 727 AASSSKAPKNGGKAKDSAKTTEETSKPKDD 756
            A      K     K+ AK+ E+   P+ +
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 185/832 (22%), Positives = 297/832 (35%), Gaps = 124/832 (14%)

Query: 10   ASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASAT 69
            +SP+P+   A   T   VS K+S  P +   KK +  K+   L  +   +         T
Sbjct: 655  SSPQPKLKTAPVTTTSAVS-KSSPQPQQTSPKKDAAPKQ--DLSKAPEPKKPPPLVKQPT 711

Query: 70   KVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPK 129
               + S    +    +     A   EP   S+  K  V  +K  Q    K  T+   L  
Sbjct: 712  LHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTD---LVS 768

Query: 130  QASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGIT--AISGKPGD 187
             +S T   D  + K  S++ E+      T+   KP       GE V+     AI     D
Sbjct: 769  SSSATTKPDIPSSKVQSQAEEKTTPPLKTD-SAKPSQSFPPTGEKVSPFDSKAIPRPASD 827

Query: 188  KK--------KEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 239
             K         E K      PV+ K +    ++ M    D      G P       T   
Sbjct: 828  SKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTA-- 885

Query: 240  GPEVSDPMSSTYIEELGKR------EVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPT 293
            G  V  P  S   +E  +R       +T  PK     ++P  P + +      F      
Sbjct: 886  GQTVPTPQQSPKPQEQSRRFSLNLGSITDAPK-----SQPTTPQETVTGKLFGF------ 934

Query: 294  AAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEP 353
              G     + S  +  A   G    + P    K+         Q   +      T QA P
Sbjct: 935  --GASIFSQASNLISTAGQPGPHSQSGPGAPMKQA----PAPSQPPTSQGPPKSTGQAPP 988

Query: 354  ELDLRSIKEVDEAKAKE-EKLEKCGEDDETIP-SEYRLKPATDKDGKPLLPEP------- 404
                +SI    E KA   EKLE   E   T+  +E   KP   KD K L  EP       
Sbjct: 989  A-PAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPT 1047

Query: 405  --EEKPKPRSESELI-DELS------EDFDR-SECKEKPS-----KPT-EKTEESKAAAP 448
              E+ PKP S   L   EL+       +F+  +ECK +        PT   TE  +    
Sbjct: 1048 KLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCL 1107

Query: 449  APVSEAVCRTSMCSIQSAPPEPATLKGT---VPDD------AVEALADSLGKKEAD--PE 497
               ++      +  I+  PP P+  K +   VP +      AV      + K+E +   E
Sbjct: 1108 NCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTE 1167

Query: 498  DGKPVMDKVKEKAK-------------------EEDREKLGEKEETIPPDYRL----EEV 534
              K +++KVKE                      E+D+    ++++ +P + +L    E++
Sbjct: 1168 AEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKI 1227

Query: 535  KDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQT 594
            + ++ KPLL    +E+ P   +  LL          Q    LK   +++  A  ++  + 
Sbjct: 1228 RSEEKKPLL----EEKKPTPEDKKLLPEAKTSAPEEQKHDLLK---SQVQIAEEKLEGRV 1280

Query: 595  PASTTQAGAPPRD-----TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKE-KAK 648
               T Q G  P+       S + + L    DK + ++ ++   P   KP  D+V+  K K
Sbjct: 1281 APKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKP--DQVEPGKEK 1338

Query: 649  AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 708
             E  D   +   +  P+    L D G        +     S  P D++D +  L  D  S
Sbjct: 1339 TEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFS 1398

Query: 709  CPSTTETSQNTAKDKCK-----KAASSSKAPKNGGKAKDSAKTTEETSKPKD 755
              S+  +  + AK +       +A +S+ A +   K     + + E  +PKD
Sbjct: 1399 QESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPE--QPKD 1448



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 127/640 (19%), Positives = 216/640 (33%), Gaps = 116/640 (18%)

Query: 4    PGQKPAASPRPRRAAAAR----RTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSR 59
            PG+ PA    P + +A +    +    +       P +PG  K   ++  ++   SQ   
Sbjct: 446  PGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQP- 504

Query: 60   TYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPK 119
                    +TK        +K S   P  TK    +P     S          +Q+  P 
Sbjct: 505  -------GSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPS----------AQQPSPA 547

Query: 120  EHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSE---KSTEPKTKPQDMISAGGE--- 173
            + +  +S  K  S TGS        VS SA+Q PS+   K+  P     +++    E   
Sbjct: 548  KPSAQQST-KPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKAN 606

Query: 174  ------------SVAG---------------------------ITAISGKPGDKKKEKKS 194
                        S+ G                           +  +   P  K K    
Sbjct: 607  FNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPV 666

Query: 195  LTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETE---EENTTYTGPEV---SDPMS 248
             T +   +S P         DAA    +     P++     ++ T +  P       P +
Sbjct: 667  TTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEA 726

Query: 249  STYIEELGKREVTIP------PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTE-- 300
             +  +    +E ++P      P   +   +P       D +SS      P     K +  
Sbjct: 727  DSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQ 786

Query: 301  -KEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRS 359
             +E++T  LK  SA   +S  P  EK    +   +   A ++   S       P  + + 
Sbjct: 787  AEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIIS----HPGPSSESKG 842

Query: 360  IKEVDEAKAKEEKLEKCGE-----DDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSES 414
             K+VD  + KEE  +   +     D + +P      P         +P P++ PKP+ +S
Sbjct: 843  QKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQS 902

Query: 415  ELIDELSEDFDRSECKEKPSKPTEKTEE-----------------SKAAAPAPVSEAVCR 457
                 L+        K +P+ P E                     S A  P P S++   
Sbjct: 903  RRF-SLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPG 961

Query: 458  TSMCSIQSAPPEPATLKGTVPD--DAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 515
              M     AP +P T +G       A  A A S+  K+   E   P  +K++ KA++   
Sbjct: 962  APM-KQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKK---ETKAPAAEKLEPKAEQAPT 1017

Query: 516  EKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMS 555
             K  E E+  PP    + +  +  K +LP + ++   P S
Sbjct: 1018 VKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPES 1057



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 141/759 (18%), Positives = 251/759 (33%), Gaps = 94/759 (12%)

Query: 1    MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPG-----------------EKKG 43
            +  P + P   P P +  A +  HE      ++ P++P                  +  G
Sbjct: 298  LPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPG 357

Query: 44   SDEKKAASLGSSQSSRTYAGGTASAT-----KVSASSGATSKSSSMNPTETKAVKTE--- 95
            + +  A  LG ++      G    ++     K  A      K+ +  P   K    +   
Sbjct: 358  TTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGT 417

Query: 96   PEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAH--------------- 140
            P+  +Q   L    +       P +   P  +P Q +  G   A                
Sbjct: 418  PKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPA 477

Query: 141  ----NKKAVSRSAEQQPSEK--------STEPKTKPQDMISAGGESVAGITAISGKPGDK 188
                 +   ++   QQP           ST+P  +         +        S +PG  
Sbjct: 478  KPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSA 537

Query: 189  KKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMS 248
            K   +  +PA P   +  KP  ++G    L     +    +   +       P  +    
Sbjct: 538  KPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTEL 597

Query: 249  STYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSS--DFTCGSPTAAGKKTEKEESTE 306
              ++ E          +          P+  +  +       C    A G       S+ 
Sbjct: 598  LLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSP 657

Query: 307  VLKAQSAGTVRSAA----PPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKE 362
              K ++A    ++A     PQ ++   +KD    Q    LS +   ++  P +   ++  
Sbjct: 658  QPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQ---DLSKAPEPKKPPPLVKQPTLHG 714

Query: 363  VDEAKAKE----EKLEKCGEDDE-TIPSEYRLKP-ATDKDGKPLLPEPEEKPKPRSESEL 416
               AKAK+    + L K     E ++PSE    P A DK  +P + +P       S +  
Sbjct: 715  SPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATT 774

Query: 417  IDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGT 476
              ++     +S+ +EK + P +      + +  P  E V          A P PA+    
Sbjct: 775  KPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFD----SKAIPRPASDSKI 830

Query: 477  VPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKD 536
            +        ++S G+K+ DP   K    K + K   +   K   K    PP  R    + 
Sbjct: 831  ISHPGPS--SESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQT 888

Query: 537  KDGKPLLPK-ESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF--EDAKLAAAISEVVSQ 593
                   PK + + +   ++   + DA     + PQ   + K     A + +  S ++S 
Sbjct: 889  VPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLIST 948

Query: 594  T----PASTTQAGAPPRDT-SQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 648
                 P S +  GAP +   + S         K   S GQ  P P ++ P    VK++ K
Sbjct: 949  AGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPK---STGQAPPAPAKSIP----VKKETK 1001

Query: 649  AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSE 687
            A   +KL  + +  P   R       + KP  PP K S+
Sbjct: 1002 APAAEKLEPKAEQAPTVKR----TETEKKP--PPIKDSK 1034



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 99/493 (20%), Positives = 185/493 (37%), Gaps = 91/493 (18%)

Query: 37   KPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEP 96
            +PG++K   E   +   SSQ  ++  G + +       S +  +  S+ PT+ K +    
Sbjct: 1333 EPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGL 1392

Query: 97   EK----------------KSQSTKLSVVH-----------EKKSQ-----EGKPKEHTEP 124
            +K                K +ST LS++            EKK+Q       +PK+  + 
Sbjct: 1393 KKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKT 1452

Query: 125  KSLPKQASDTGSNDAHNKKAVSR-------SAEQQPSEKSTEPKTKPQDMISAGGE---S 174
            +SL +    T S +   +    R       S +  PS K  + K++  D I+   E   S
Sbjct: 1453 QSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDS 1512

Query: 175  VAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGK-SGMDAALDDLIDTLGGPEETEE 233
            V   +     P  ++K + S+  +   E K +   G     D     +I+     + +  
Sbjct: 1513 VEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGS 1572

Query: 234  ENTTYTGPEVSDPMSSTYI----EELGKREVTIPPKYRELLAK-------PIGPDDAIDA 282
            E+  +   ++ +  SST      E  GK ++T   K+R L  K         G   +   
Sbjct: 1573 EDDEFIRNQLKEISSSTESQKKEETKGKGKIT-AGKHRRLTRKSSTSIDEDAGRRHSWHD 1631

Query: 283  LSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEAL 342
               +    SP    ++T+ +ES E++     G  R         + +E ++       A 
Sbjct: 1632 EDDEAFDESPELKYRETKSQESEELVVTGGGGLRRF--------KTIELNSTIADKYSAE 1683

Query: 343  SASLGTR---QAEPELDLRSIKEVDEAKAKEE-----------------KLEKCGEDDET 382
            S+   T      EPEL++ S+ +  E +++ E                  +    ED ++
Sbjct: 1684 SSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDS 1743

Query: 383  IPSEYR-----LKPATDKDGKPLLP---EPEEKPKPRSESELIDELSEDFDRSECKEKPS 434
             PS  +      + A  +   PLLP   +  E+ + R E EL+ E  +  +  + + K S
Sbjct: 1744 SPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSS 1803

Query: 435  KPTEKTEESKAAA 447
                K ++ +  A
Sbjct: 1804 SKKSKKDKDELRA 1816



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 146/696 (20%), Positives = 247/696 (35%), Gaps = 99/696 (14%)

Query: 56   QSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEK-----KSQSTKLSVVHE 110
            Q+ R  +G      K+  +      S    PTE+ + KT         K Q  ++    E
Sbjct: 1110 QTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAE 1169

Query: 111  KKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISA 170
            K   E K KE    + +P   +     +    +    SA Q+      E K  P++    
Sbjct: 1170 KVILE-KVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIR 1228

Query: 171  GGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTL----- 225
              E    +      P DKK   ++ T A P E K D    KS +  A + L   +     
Sbjct: 1229 SEEKKPLLEEKKPTPEDKKLLPEAKTSA-PEEQKHDLL--KSQVQIAEEKLEGRVAPKTV 1285

Query: 226  --GGPEETEEEN----TTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDA 279
              G   +T+ E     T  + P+  D  + T  E+        P +      K    DD 
Sbjct: 1286 QEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDK 1345

Query: 280  IDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKK--RKVEKDTMSDQ 337
             D  SS      P +    ++   S++ + + S G + S  P  EK   + ++KD+ S +
Sbjct: 1346 SDTSSSQ----QPKSPQGLSDTGYSSDGISS-SLGEIPSLIPTDEKDILKGLKKDSFSQE 1400

Query: 338  ALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDG 397
            +  +  + L    A+ E  + SI E   +   +EK EK  +  E  P + + +  T    
Sbjct: 1401 SSPSSPSDL----AKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLS 1456

Query: 398  KPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCR 457
            + L     E+    S+ E  D   +D  +     K  K  EK+E         V +   R
Sbjct: 1457 ETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHK--EKSEF--------VDDITTR 1506

Query: 458  TSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREK 517
                                P D+VE  ++S        +    V     ++ K+ED + 
Sbjct: 1507 RE------------------PYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQG 1548

Query: 518  LGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLK 577
             GE+E+ I     +E   D+D                 ++F+ + L E  S  ++    +
Sbjct: 1549 SGEEEDFIRKQI-IEMSADEDAS-----------GSEDDEFIRNQLKEISSSTESQKKEE 1596

Query: 578  FE-DAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDEN 636
             +   K+ A     +++  +++    A  R  S  D+D D+A D+ S  L  R+    E+
Sbjct: 1597 TKGKGKITAGKHRRLTRKSSTSIDEDAGRRH-SWHDED-DEAFDE-SPELKYRETKSQES 1653

Query: 637  KPMEDKVKEKAKAEHRDKLGERDDTIPPEY--------RHLLDDNGQDKPVKPPTKKSED 688
               E+ V        R K  E + TI  +Y          L  D   +  ++  T   ED
Sbjct: 1654 ---EELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPED 1710

Query: 689  SKK-------------PADDQDPIDALSGDLDSCPS 711
              +             P      + +L  D DS PS
Sbjct: 1711 RSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPS 1746



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 64/276 (23%), Positives = 103/276 (37%), Gaps = 48/276 (17%)

Query: 56   QSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTE--PEKKSQSTKLSVVHEKKS 113
            QS   Y   +   T+  A  G  S  S +  T+   VK E  P+K+S   K+   ++   
Sbjct: 3369 QSQGWYTVQSDGVTQYIAPPGILSTVSEIPLTDV-VVKEEKQPKKRSSGAKVRGQYDDMG 3427

Query: 114  QEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGE 173
             E    +    K +      T   DA ++  VSR    + S   T  +T  +D       
Sbjct: 3428 -ENMTDDPRSFKKIVDSGVQTDDEDATDRSYVSRRRRTKKSV-DTSVQTDDEDQDEWDMP 3485

Query: 174  SVAGITAISGKPGDKKKEKKSLTPA-------------VPVESKP----DKPSGKSGMDA 216
            + +   A  GK GD   E     P              + V+++P      PS ++ +DA
Sbjct: 3486 TRSRRKARVGKYGDSMTEADKTKPLSKVSSIAVQTVAEISVQTEPVGTIRTPSIRARVDA 3545

Query: 217  ALDDLIDTLGGPEETEEENTTYTGPEV-SDPMSSTYIE--------------ELG----- 256
             ++ +I  +  PE+T +  +     E  SD  S  Y+               E+G     
Sbjct: 3546 KVE-IIKHISAPEKTYKGGSLGCQTEADSDTQSPQYLSATSPPKDKKRPTPLEIGYSSHL 3604

Query: 257  KREVTI-----PPKYRELLAKPIGPDDAIDALSSDF 287
            + + T+     PPK  ++L  PI P     AL S F
Sbjct: 3605 RADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAF 3640


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 185/832 (22%), Positives = 297/832 (35%), Gaps = 124/832 (14%)

Query: 10   ASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASAT 69
            +SP+P+   A   T   VS K+S  P +   KK +  K+   L  +   +         T
Sbjct: 655  SSPQPKLKTAPVTTTSAVS-KSSPQPQQTSPKKDAAPKQ--DLSKAPEPKKPPPLVKQPT 711

Query: 70   KVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPK 129
               + S    +    +     A   EP   S+  K  V  +K  Q    K  T+   L  
Sbjct: 712  LHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTD---LVS 768

Query: 130  QASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGIT--AISGKPGD 187
             +S T   D  + K  S++ E+      T+   KP       GE V+     AI     D
Sbjct: 769  SSSATTKPDIPSSKVQSQAEEKTTPPLKTD-SAKPSQSFPPTGEKVSPFDSKAIPRPASD 827

Query: 188  KK--------KEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 239
             K         E K      PV+ K +    ++ M    D      G P       T   
Sbjct: 828  SKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTA-- 885

Query: 240  GPEVSDPMSSTYIEELGKR------EVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPT 293
            G  V  P  S   +E  +R       +T  PK     ++P  P + +      F      
Sbjct: 886  GQTVPTPQQSPKPQEQSRRFSLNLGSITDAPK-----SQPTTPQETVTGKLFGF------ 934

Query: 294  AAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEP 353
              G     + S  +  A   G    + P    K+         Q   +      T QA P
Sbjct: 935  --GASIFSQASNLISTAGQPGPHSQSGPGAPMKQA----PAPSQPPTSQGPPKSTGQAPP 988

Query: 354  ELDLRSIKEVDEAKAKE-EKLEKCGEDDETIP-SEYRLKPATDKDGKPLLPEP------- 404
                +SI    E KA   EKLE   E   T+  +E   KP   KD K L  EP       
Sbjct: 989  A-PAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPT 1047

Query: 405  --EEKPKPRSESELI-DELS------EDFDR-SECKEKPS-----KPT-EKTEESKAAAP 448
              E+ PKP S   L   EL+       +F+  +ECK +        PT   TE  +    
Sbjct: 1048 KLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCL 1107

Query: 449  APVSEAVCRTSMCSIQSAPPEPATLKGT---VPDD------AVEALADSLGKKEAD--PE 497
               ++      +  I+  PP P+  K +   VP +      AV      + K+E +   E
Sbjct: 1108 NCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTE 1167

Query: 498  DGKPVMDKVKEKAK-------------------EEDREKLGEKEETIPPDYRL----EEV 534
              K +++KVKE                      E+D+    ++++ +P + +L    E++
Sbjct: 1168 AEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKI 1227

Query: 535  KDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQT 594
            + ++ KPLL    +E+ P   +  LL          Q    LK   +++  A  ++  + 
Sbjct: 1228 RSEEKKPLL----EEKKPTPEDKKLLPEAKTSAPEEQKHDLLK---SQVQIAEEKLEGRV 1280

Query: 595  PASTTQAGAPPRD-----TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKE-KAK 648
               T Q G  P+       S + + L    DK + ++ ++   P   KP  D+V+  K K
Sbjct: 1281 APKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKP--DQVEPGKEK 1338

Query: 649  AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 708
             E  D   +   +  P+    L D G        +     S  P D++D +  L  D  S
Sbjct: 1339 TEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFS 1398

Query: 709  CPSTTETSQNTAKDKCK-----KAASSSKAPKNGGKAKDSAKTTEETSKPKD 755
              S+  +  + AK +       +A +S+ A +   K     + + E  +PKD
Sbjct: 1399 QESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPE--QPKD 1448



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 127/640 (19%), Positives = 216/640 (33%), Gaps = 116/640 (18%)

Query: 4    PGQKPAASPRPRRAAAAR----RTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSR 59
            PG+ PA    P + +A +    +    +       P +PG  K   ++  ++   SQ   
Sbjct: 446  PGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQP- 504

Query: 60   TYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPK 119
                    +TK        +K S   P  TK    +P     S          +Q+  P 
Sbjct: 505  -------GSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPS----------AQQPSPA 547

Query: 120  EHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSE---KSTEPKTKPQDMISAGGE--- 173
            + +  +S  K  S TGS        VS SA+Q PS+   K+  P     +++    E   
Sbjct: 548  KPSAQQST-KPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKAN 606

Query: 174  ------------SVAG---------------------------ITAISGKPGDKKKEKKS 194
                        S+ G                           +  +   P  K K    
Sbjct: 607  FNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPV 666

Query: 195  LTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETE---EENTTYTGPEV---SDPMS 248
             T +   +S P         DAA    +     P++     ++ T +  P       P +
Sbjct: 667  TTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEA 726

Query: 249  STYIEELGKREVTIP------PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTE-- 300
             +  +    +E ++P      P   +   +P       D +SS      P     K +  
Sbjct: 727  DSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQ 786

Query: 301  -KEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRS 359
             +E++T  LK  SA   +S  P  EK    +   +   A ++   S       P  + + 
Sbjct: 787  AEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIIS----HPGPSSESKG 842

Query: 360  IKEVDEAKAKEEKLEKCGE-----DDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSES 414
             K+VD  + KEE  +   +     D + +P      P         +P P++ PKP+ +S
Sbjct: 843  QKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQS 902

Query: 415  ELIDELSEDFDRSECKEKPSKPTEKTEE-----------------SKAAAPAPVSEAVCR 457
                 L+        K +P+ P E                     S A  P P S++   
Sbjct: 903  RRF-SLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPG 961

Query: 458  TSMCSIQSAPPEPATLKGTVPD--DAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 515
              M     AP +P T +G       A  A A S+  K+   E   P  +K++ KA++   
Sbjct: 962  APM-KQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKK---ETKAPAAEKLEPKAEQAPT 1017

Query: 516  EKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMS 555
             K  E E+  PP    + +  +  K +LP + ++   P S
Sbjct: 1018 VKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPES 1057



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 141/759 (18%), Positives = 251/759 (33%), Gaps = 94/759 (12%)

Query: 1    MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPG-----------------EKKG 43
            +  P + P   P P +  A +  HE      ++ P++P                  +  G
Sbjct: 298  LPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPG 357

Query: 44   SDEKKAASLGSSQSSRTYAGGTASAT-----KVSASSGATSKSSSMNPTETKAVKTE--- 95
            + +  A  LG ++      G    ++     K  A      K+ +  P   K    +   
Sbjct: 358  TTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGT 417

Query: 96   PEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAH--------------- 140
            P+  +Q   L    +       P +   P  +P Q +  G   A                
Sbjct: 418  PKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPA 477

Query: 141  ----NKKAVSRSAEQQPSEK--------STEPKTKPQDMISAGGESVAGITAISGKPGDK 188
                 +   ++   QQP           ST+P  +         +        S +PG  
Sbjct: 478  KPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSA 537

Query: 189  KKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMS 248
            K   +  +PA P   +  KP  ++G    L     +    +   +       P  +    
Sbjct: 538  KPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTEL 597

Query: 249  STYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSS--DFTCGSPTAAGKKTEKEESTE 306
              ++ E          +          P+  +  +       C    A G       S+ 
Sbjct: 598  LLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSP 657

Query: 307  VLKAQSAGTVRSAA----PPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKE 362
              K ++A    ++A     PQ ++   +KD    Q    LS +   ++  P +   ++  
Sbjct: 658  QPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQ---DLSKAPEPKKPPPLVKQPTLHG 714

Query: 363  VDEAKAKE----EKLEKCGEDDE-TIPSEYRLKP-ATDKDGKPLLPEPEEKPKPRSESEL 416
               AKAK+    + L K     E ++PSE    P A DK  +P + +P       S +  
Sbjct: 715  SPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATT 774

Query: 417  IDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGT 476
              ++     +S+ +EK + P +      + +  P  E V          A P PA+    
Sbjct: 775  KPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFD----SKAIPRPASDSKI 830

Query: 477  VPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKD 536
            +        ++S G+K+ DP   K    K + K   +   K   K    PP  R    + 
Sbjct: 831  ISHPGPS--SESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQT 888

Query: 537  KDGKPLLPK-ESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF--EDAKLAAAISEVVSQ 593
                   PK + + +   ++   + DA     + PQ   + K     A + +  S ++S 
Sbjct: 889  VPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLIST 948

Query: 594  T----PASTTQAGAPPRDT-SQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 648
                 P S +  GAP +   + S         K   S GQ  P P ++ P    VK++ K
Sbjct: 949  AGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPK---STGQAPPAPAKSIP----VKKETK 1001

Query: 649  AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSE 687
            A   +KL  + +  P   R       + KP  PP K S+
Sbjct: 1002 APAAEKLEPKAEQAPTVKR----TETEKKP--PPIKDSK 1034



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 99/493 (20%), Positives = 185/493 (37%), Gaps = 91/493 (18%)

Query: 37   KPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEP 96
            +PG++K   E   +   SSQ  ++  G + +       S +  +  S+ PT+ K +    
Sbjct: 1333 EPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGL 1392

Query: 97   EK----------------KSQSTKLSVVH-----------EKKSQ-----EGKPKEHTEP 124
            +K                K +ST LS++            EKK+Q       +PK+  + 
Sbjct: 1393 KKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKT 1452

Query: 125  KSLPKQASDTGSNDAHNKKAVSR-------SAEQQPSEKSTEPKTKPQDMISAGGE---S 174
            +SL +    T S +   +    R       S +  PS K  + K++  D I+   E   S
Sbjct: 1453 QSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDS 1512

Query: 175  VAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGK-SGMDAALDDLIDTLGGPEETEE 233
            V   +     P  ++K + S+  +   E K +   G     D     +I+     + +  
Sbjct: 1513 VEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGS 1572

Query: 234  ENTTYTGPEVSDPMSSTYI----EELGKREVTIPPKYRELLAK-------PIGPDDAIDA 282
            E+  +   ++ +  SST      E  GK ++T   K+R L  K         G   +   
Sbjct: 1573 EDDEFIRNQLKEISSSTESQKKEETKGKGKIT-AGKHRRLTRKSSTSIDEDAGRRHSWHD 1631

Query: 283  LSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEAL 342
               +    SP    ++T+ +ES E++     G  R         + +E ++       A 
Sbjct: 1632 EDDEAFDESPELKYRETKSQESEELVVTGGGGLRRF--------KTIELNSTIADKYSAE 1683

Query: 343  SASLGTR---QAEPELDLRSIKEVDEAKAKEE-----------------KLEKCGEDDET 382
            S+   T      EPEL++ S+ +  E +++ E                  +    ED ++
Sbjct: 1684 SSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDS 1743

Query: 383  IPSEYR-----LKPATDKDGKPLLP---EPEEKPKPRSESELIDELSEDFDRSECKEKPS 434
             PS  +      + A  +   PLLP   +  E+ + R E EL+ E  +  +  + + K S
Sbjct: 1744 SPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSS 1803

Query: 435  KPTEKTEESKAAA 447
                K ++ +  A
Sbjct: 1804 SKKSKKDKDELRA 1816



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 146/696 (20%), Positives = 247/696 (35%), Gaps = 99/696 (14%)

Query: 56   QSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEK-----KSQSTKLSVVHE 110
            Q+ R  +G      K+  +      S    PTE+ + KT         K Q  ++    E
Sbjct: 1110 QTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAE 1169

Query: 111  KKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISA 170
            K   E K KE    + +P   +     +    +    SA Q+      E K  P++    
Sbjct: 1170 KVILE-KVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIR 1228

Query: 171  GGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTL----- 225
              E    +      P DKK   ++ T A P E K D    KS +  A + L   +     
Sbjct: 1229 SEEKKPLLEEKKPTPEDKKLLPEAKTSA-PEEQKHDLL--KSQVQIAEEKLEGRVAPKTV 1285

Query: 226  --GGPEETEEEN----TTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDA 279
              G   +T+ E     T  + P+  D  + T  E+        P +      K    DD 
Sbjct: 1286 QEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDK 1345

Query: 280  IDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKK--RKVEKDTMSDQ 337
             D  SS      P +    ++   S++ + + S G + S  P  EK   + ++KD+ S +
Sbjct: 1346 SDTSSSQ----QPKSPQGLSDTGYSSDGISS-SLGEIPSLIPTDEKDILKGLKKDSFSQE 1400

Query: 338  ALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDG 397
            +  +  + L    A+ E  + SI E   +   +EK EK  +  E  P + + +  T    
Sbjct: 1401 SSPSSPSDL----AKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLS 1456

Query: 398  KPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCR 457
            + L     E+    S+ E  D   +D  +     K  K  EK+E         V +   R
Sbjct: 1457 ETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHK--EKSEF--------VDDITTR 1506

Query: 458  TSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREK 517
                                P D+VE  ++S        +    V     ++ K+ED + 
Sbjct: 1507 RE------------------PYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQG 1548

Query: 518  LGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLK 577
             GE+E+ I     +E   D+D                 ++F+ + L E  S  ++    +
Sbjct: 1549 SGEEEDFIRKQI-IEMSADEDAS-----------GSEDDEFIRNQLKEISSSTESQKKEE 1596

Query: 578  FE-DAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDEN 636
             +   K+ A     +++  +++    A  R  S  D+D D+A D+ S  L  R+    E+
Sbjct: 1597 TKGKGKITAGKHRRLTRKSSTSIDEDAGRRH-SWHDED-DEAFDE-SPELKYRETKSQES 1653

Query: 637  KPMEDKVKEKAKAEHRDKLGERDDTIPPEY--------RHLLDDNGQDKPVKPPTKKSED 688
               E+ V        R K  E + TI  +Y          L  D   +  ++  T   ED
Sbjct: 1654 ---EELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPED 1710

Query: 689  SKK-------------PADDQDPIDALSGDLDSCPS 711
              +             P      + +L  D DS PS
Sbjct: 1711 RSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPS 1746



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 64/276 (23%), Positives = 103/276 (37%), Gaps = 48/276 (17%)

Query: 56   QSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTE--PEKKSQSTKLSVVHEKKS 113
            QS   Y   +   T+  A  G  S  S +  T+   VK E  P+K+S   K+   ++   
Sbjct: 3369 QSQGWYTVQSDGVTQYIAPPGILSTVSEIPLTDV-VVKEEKQPKKRSSGAKVRGQYDDMG 3427

Query: 114  QEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGE 173
             E    +    K +      T   DA ++  VSR    + S   T  +T  +D       
Sbjct: 3428 -ENMTDDPRSFKKIVDSGVQTDDEDATDRSYVSRRRRTKKSV-DTSVQTDDEDQDEWDMP 3485

Query: 174  SVAGITAISGKPGDKKKEKKSLTPA-------------VPVESKP----DKPSGKSGMDA 216
            + +   A  GK GD   E     P              + V+++P      PS ++ +DA
Sbjct: 3486 TRSRRKARVGKYGDSMTEADKTKPLSKVSSIAVQTVAEISVQTEPVGTIRTPSIRARVDA 3545

Query: 217  ALDDLIDTLGGPEETEEENTTYTGPEV-SDPMSSTYIE--------------ELG----- 256
             ++ +I  +  PE+T +  +     E  SD  S  Y+               E+G     
Sbjct: 3546 KVE-IIKHISAPEKTYKGGSLGCQTEADSDTQSPQYLSATSPPKDKKRPTPLEIGYSSHL 3604

Query: 257  KREVTI-----PPKYRELLAKPIGPDDAIDALSSDF 287
            + + T+     PPK  ++L  PI P     AL S F
Sbjct: 3605 RADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAF 3640


>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
          Length = 1163

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 158/828 (19%), Positives = 291/828 (35%), Gaps = 121/828 (14%)

Query: 24  HEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSA---------S 74
           H    + +  +P  P       +K+++ L S  SS+  + G++S T  S          +
Sbjct: 99  HGGSHQSSKWTPVGPAPSTSQSQKRSSGLQSGHSSQRTSAGSSSGTNSSGQRHDRESYNN 158

Query: 75  SGATSKSSSMNPTE-TKAVKTEPEKKSQSTKLSVVHEKK-SQEGKPKEHTEPKSL--PKQ 130
           SG++S+    + +E +K+  + P K    + L+  H +    +   KEH   KS   P  
Sbjct: 159 SGSSSRKKGQHGSEHSKSRSSSPGKPQAVSSLNSSHSRSHGNDHHSKEHQRSKSPRDPDA 218

Query: 131 ASDTGS-----NDAHNKKAV-------SRSAEQQPS--------EKSTEPKTKPQDMISA 170
             D+ S     +  H+ ++        S S  Q+P+        ++S EPK   +   S 
Sbjct: 219 NWDSPSRVPFSSGQHSTQSFPPSLMSKSNSMLQKPTAYVRPMDGQESMEPKLSSEHYSSQ 278

Query: 171 G-GESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDL-------I 222
             G S+  +     KP  K    K   P+ P+++        S +D  L ++       +
Sbjct: 279 SHGNSMTEL-----KPSSKAHLTKLKIPSQPLDASAS--GDVSCVDEILKEMTHSWPPPL 331

Query: 223 DTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKP----IGPDD 278
             +  P +TE     +   E       T  ++      T      + + K        +D
Sbjct: 332 TAIHTPCKTEPSKFPFPTKESQQSNFGTGEQKRYNPSKTSNGHQSKSMLKDDLKLSSSED 391

Query: 279 AIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQA 338
           +      D T    T          ++E   A ++    S+    E     + ++ S  +
Sbjct: 392 SDGEQDCDKTMPRSTPGSNSEPSHHNSE--GADNSRDDSSSHSGSESSSGSDSESESSSS 449

Query: 339 LEALSASLGTRQAEPELDLRSIKEVDE--AKAKEEKLEKCGEDDETIPSEYRLKPA---- 392
               +    +   EPE    +  ++D    K    K+      D  IPS    K      
Sbjct: 450 DSEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGREQ 509

Query: 393 ------TDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 446
                 TD  G    P+      P  +S+ I + SE     +     S  T +       
Sbjct: 510 GTGNSYTDTSG----PKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKK 565

Query: 447 APAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGK---KEADPEDGKPVM 503
            P    +A        ++     P  L  ++P    +A      K   K+      +P  
Sbjct: 566 QPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESKSSPRPTA 625

Query: 504 DKVKEKAKEEDREKLGE------------KEETIPPDYRLEEVKDKDGKPLLPKESKEQ- 550
           +K K K+  +  +K  E            + E++PP  +  +  + +  P+ P   +E+ 
Sbjct: 626 EKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSSVEEED 685

Query: 551 -------LPPMSEDFLLDALSEDFSGPQNASSL--KFEDAKLAAAISEVVSQT-PASTTQ 600
                    PM E  LL  LSE    P +   L  K +   L     +   +T P    +
Sbjct: 686 SFFRQRMFSPMEEKELLSPLSE----PDDRYPLIVKIDLNLLTRIPGKPYKETEPPKGEK 741

Query: 601 AGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDD 660
              P + T ++ K    A +K+S+   ++  + D+N+  E K   K K E ++  G +  
Sbjct: 742 KNVPEKHTREAQKQ---ASEKVSNKGKRKHKNEDDNRASESK---KPKTEDKNSAGHKPS 795

Query: 661 T-------IPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTT 713
           +          + + LL       P K P  +    K+       + + S        ++
Sbjct: 796 SNRESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSS 855

Query: 714 ETSQNTAKDKCKKAASSS-------KAPKNGGKAKDSAKTTEETSKPK 754
           + S +T+K K  +  +SS       KAP +      SA T  ++SKP+
Sbjct: 856 KNSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTL-DSSKPR 902



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 166/768 (21%), Positives = 271/768 (35%), Gaps = 138/768 (17%)

Query: 5   GQKPAASPRPRRAAAARRTHEHVSEKT---SESPSKPGEKKGSDEKKAASLGSSQSSRTY 61
           GQ+          +++R+  +H SE +   S SP KP      +   + S G+   S+ +
Sbjct: 148 GQRHDRESYNNSGSSSRKKGQHGSEHSKSRSSSPGKPQAVSSLNSSHSRSHGNDHHSKEH 207

Query: 62  AGGTA---------SATKVSASSGA----------TSKSSSMNPTETKAVKTEPEKKSQS 102
               +         S ++V  SSG            SKS+SM    T  V+    ++S  
Sbjct: 208 QRSKSPRDPDANWDSPSRVPFSSGQHSTQSFPPSLMSKSNSMLQKPTAYVRPMDGQESME 267

Query: 103 TKLSVVHEKKSQEG------KP--KEHTEPKSLPKQASDTGSND------------AHN- 141
            KLS  H      G      KP  K H     +P Q  D  ++              H+ 
Sbjct: 268 PKLSSEHYSSQSHGNSMTELKPSSKAHLTKLKIPSQPLDASASGDVSCVDEILKEMTHSW 327

Query: 142 ---KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPA 198
                A+    + +PS+     K   Q     G +     +  S     K   K  L  +
Sbjct: 328 PPPLTAIHTPCKTEPSKFPFPTKESQQSNFGTGEQKRYNPSKTSNGHQSKSMLKDDLKLS 387

Query: 199 VPVESKP----DKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEE 254
              +S      DK   +S   +  +       G + + +++++++G E S    S     
Sbjct: 388 SSEDSDGEQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESS 447

Query: 255 LGKREVTIPPKYRELLAKP--------------IGPDDAIDALSSDFTCGSPTAAG-KKT 299
               E   P +      +P              + P     A S D     P++ G KK 
Sbjct: 448 SSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVD--SNIPSSQGYKKE 505

Query: 300 EKEESTEVLKAQSAGTVR-SAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLR 358
            +E+ T      ++G    S+A P    + ++K + S +  +   A   +      +  +
Sbjct: 506 GREQGTGNSYTDTSGPKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKK 565

Query: 359 SIKEVDEAKAKEE----KLEKCGEDD--ETIPSEYRLKPATDKDGKP-LLPEPEEKPKPR 411
             K+ ++A A+E     K+E     D   ++PS  R K AT    KP +  E +  P+P 
Sbjct: 566 QPKKAEKAAAEEPRGGLKIESETPVDLASSMPSS-RHKAATKGSRKPNIKKESKSSPRPT 624

Query: 412 SES--------------ELI--DELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAV 455
           +E               E+I  D  S D D SE    PS  T K  ES      P S   
Sbjct: 625 AEKKKYKSTSKSSQKSREIIETDTSSSDSDESE-SLPPSSQTPKYPESNRTPVKPSSVEE 683

Query: 456 CRTSMCSIQSAPPEPATLKGTV--PDDA--------VEALADSLGK--KEADPEDG--KP 501
             +       +P E   L   +  PDD         +  L    GK  KE +P  G  K 
Sbjct: 684 EDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPYKETEPPKGEKKN 743

Query: 502 VMDKVKEKAKEEDREKL---GEKEETIPPDYRLEEVK-----DKDG---KPLLPKESKEQ 550
           V +K   +A+++  EK+   G+++     D R  E K     DK+    KP   +ES +Q
Sbjct: 744 VPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKPKTEDKNSAGHKPSSNRESSKQ 803

Query: 551 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEV---------------VSQTP 595
                +D L        +GP  +   K E       IS+                 S+  
Sbjct: 804 SAAKEKDLLPSP-----AGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSKNS 858

Query: 596 ASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKV 643
           +ST++       TS S K++ +     S +     P  D +KP   K+
Sbjct: 859 SSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTLDSSKPRRTKL 906


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 94/454 (20%), Positives = 167/454 (36%), Gaps = 58/454 (12%)

Query: 10  ASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTY----AGGT 65
           A P+P RAA      +  S  +S S S   +   S+E+KAA+       +      A   
Sbjct: 198 APPKPARAAPKIANGKAASSSSSSSSSSSSDD--SEEEKAAATPKKTVPKKQVVAKAPVK 255

Query: 66  ASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK 125
           A+ T    SS +   SS     + K +K +P   S     S    KKS   +P +    K
Sbjct: 256 AATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEK 315

Query: 126 SLPKQASDTGSNDAHN----------KKAVSRSAEQQP-SEKSTEPKTKPQDMISAGGES 174
             P ++S+  S+++ +          K  VS++  + P ++K+ E  +   D  S+  + 
Sbjct: 316 QQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDE 375

Query: 175 VAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEE 234
                A + K    K    + +PAV   + P +P G          L+        +EEE
Sbjct: 376 APSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGG------QKLLTRKADSSSSEEE 429

Query: 235 NTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTA 294
           +++    +    +++T  +   K  +++P K       P G  D+    SSD    S   
Sbjct: 430 SSSSEEEKTKKMVATTKPKATAKAALSLPAKQA-----PQGSRDS----SSDSDSSSSEE 480

Query: 295 AGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPE 354
             +KT K  + +    + AG    + P   KK K E    S                   
Sbjct: 481 EEEKTSKS-AVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSD---------------- 523

Query: 355 LDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSES 414
                    D ++ +EEKL+  G      P        T ++GK      EE+ + +  +
Sbjct: 524 ---------DSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAA 574

Query: 415 ELIDELSEDFDRSECKEKPSKPTEKTEESKAAAP 448
            ++ +      R + +      T + ++ K   P
Sbjct: 575 VVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTP 608



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 130/610 (21%), Positives = 215/610 (35%), Gaps = 131/610 (21%)

Query: 63  GGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHT 122
           G  A   K  ASS  +  SS     E + V+  P KK+      V        G P    
Sbjct: 72  GPVAKKAKKKASSSDSEDSSE----EEEEVQGPPAKKAAVPAKRV--------GLP---- 115

Query: 123 EPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAIS 182
            P     +AS++ S++  +        ++QP +K  +P+ K         +S    +  S
Sbjct: 116 -PGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSS 174

Query: 183 GKPGDKKKEKKSLTPA-VPVESK-PDKPSGKS-----GMDAALDDLIDTLGGPEETEEEN 235
            +    K +K  +TP  V  ++K P KP+  +     G  A+      +    +++EEE 
Sbjct: 175 SEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEK 234

Query: 236 TTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAA 295
              T  +                  T+P K  +++AK       + A ++     S +  
Sbjct: 235 AAATPKK------------------TVPKK--QVVAKA-----PVKAATTPTRKSSSSED 269

Query: 296 GKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPEL 355
               E+EE  + +K    G   S  PP     K                SLGT+  +   
Sbjct: 270 SSSDEEEEQKKPMK-NKPGPYSSVPPPSAPPPK---------------KSLGTQPPK--- 310

Query: 356 DLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESE 415
                K V++ +  E   +   E D +  SE   KP T    K ++ +   KP P  ++ 
Sbjct: 311 -----KAVEKQQPVESSEDSSDESDSS--SEEEKKPPT----KAVVSKATTKPPPAKKAA 359

Query: 416 LIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKG 475
                S D D SE  E PSKP   T+ S +  PA  +++               PA    
Sbjct: 360 ESSSDSSDSDSSEDDEAPSKPAGTTKNS-SNKPAVTTKS---------------PAVKPA 403

Query: 476 TVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVK 535
             P   V                G+ ++ +  + +  E+     E+E+T      +   K
Sbjct: 404 AAPKQPVGG--------------GQKLLTRKADSSSSEEESSSSEEEKT---KKMVATTK 446

Query: 536 DKDGKPLLPKESKEQLPPMSEDFLLD---ALSEDFSGPQNASSLKFEDAKLAAAISEVVS 592
            K           +Q P  S D   D   + SE+     + S++K +  K+A        
Sbjct: 447 PKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGG---AAP 503

Query: 593 QTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDEN-------------KPM 639
             PAS  +  A   ++S SD   ++  +KL      R   P  N             K  
Sbjct: 504 SKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNS 563

Query: 640 EDKVKEKAKA 649
           E++ +EK KA
Sbjct: 564 EEEEEEKKKA 573



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 84/379 (22%), Positives = 139/379 (36%), Gaps = 67/379 (17%)

Query: 426 RSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEAL 485
           +++ K   S   + +EE +     P  +A        +   PP  A  K +    + E+ 
Sbjct: 77  KAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGL---PPGKAAAKASESSSSEESS 133

Query: 486 ADSLGKKEADPEDGK--PVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 543
            D       D ED K  PV   VK +AK         K      D   E+   K+ KP +
Sbjct: 134 DDD------DEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKI 187

Query: 544 -----------PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVS 592
                      P +     P ++      A S   S   ++SS   E+ K AA   + V 
Sbjct: 188 TPVTVKAQTKAPPKPARAAPKIANG---KAASSSSSSSSSSSSDDSEEEKAAATPKKTVP 244

Query: 593 Q----TPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQ-----------PDPDEN- 636
           +      A    A  P R +S S+    D  ++    +  +            P P ++ 
Sbjct: 245 KKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSL 304

Query: 637 --KPMEDKVKEKAKAEHRDKLGERDDTIPPEYRH----LLDDNGQDKPVKPPTKKSEDSK 690
             +P +  V+++   E  +   +  D+   E +      +      KP  PP KK+ +S 
Sbjct: 305 GTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKP--PPAKKAAESS 362

Query: 691 KPADDQDPIDALSGDLDSCPS----TTETSQN----TAKDKCKKAASSSKAPKNGG---- 738
             + D D     S + D  PS    TT+ S N    T K    K A++ K P  GG    
Sbjct: 363 SDSSDSD-----SSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLL 417

Query: 739 -KAKDSAKTTEETSKPKDD 756
            +  DS+ + EE+S  +++
Sbjct: 418 TRKADSSSSEEESSSSEEE 436



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 114/549 (20%), Positives = 185/549 (33%), Gaps = 67/549 (12%)

Query: 30  KTSESPSKPGEKKGSDEKKAASLGSSQSSRTYA-------GGTASATKVSAS-------S 75
           K+++ P +  +  G   KKA    SS  S   +       G  A    V A         
Sbjct: 59  KSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGK 118

Query: 76  GATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTG 135
            A   S S +  E+     E ++K Q  +  V  + K+ +  PK+     S     SD+ 
Sbjct: 119 AAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDS----DSDSS 174

Query: 136 SNDA---HNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEK 192
           S D    + K  ++    +  ++   +P      + +    S +  ++ S    D ++EK
Sbjct: 175 SEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEK 234

Query: 193 KSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYI 252
            + TP   V  K  +   K+ + AA                  TT T    S   SS+  
Sbjct: 235 AAATPKKTVPKK--QVVAKAPVKAA------------------TTPTRKSSSSEDSSSDE 274

Query: 253 EELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQS 312
           EE  K+ +   P     +  P  P               P  A +K +  ES+E    +S
Sbjct: 275 EEEQKKPMKNKPGPYSSVPPPSAPPP-----KKSLGTQPPKKAVEKQQPVESSEDSSDES 329

Query: 313 AGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEK 372
             +      P  K    +  T    A +A  +S  +  ++   D       DEA +K   
Sbjct: 330 DSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSED-------DEAPSKPAG 382

Query: 373 LEKCGEDDETIPSEY-RLKPATDK-----DGKPLLPEPEEKPKPRSESELIDELSEDFDR 426
             K   +   + ++   +KPA         G+ LL    +      ES   +E  E   +
Sbjct: 383 TTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEE--EKTKK 440

Query: 427 SECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALA 486
                KP K T K   S  A  AP       +   S  S   E  T K  V     +   
Sbjct: 441 MVATTKP-KATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAG 499

Query: 487 DSLGKKEADPEDGKPVM--DKVKEKAKEEDREKL---GEKEETIPPDYRLEEVKDKDGKP 541
            +   K A  + GK         + + EE+ EKL   G      P       +  ++GK 
Sbjct: 500 GAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKA 559

Query: 542 LLPKESKEQ 550
               E +E+
Sbjct: 560 AKNSEEEEE 568



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 41/174 (23%), Positives = 70/174 (40%), Gaps = 21/174 (12%)

Query: 4   PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAG 63
           P  KPAA+P+       +         +SE  S   E++ + +  A +   + +    + 
Sbjct: 398 PAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSL 457

Query: 64  GTASATKVSASSGATSKSSSMNPTETK----AVKTEPEK----------------KSQST 103
               A + S  S + S SSS    E K    AVK +P+K                K++S+
Sbjct: 458 PAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESS 517

Query: 104 KLSVVHE-KKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEK 156
             S   +  + +E K K    P+    +A+ T +  A N KA   S E++  +K
Sbjct: 518 NSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKK 571



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 34/141 (24%), Positives = 54/141 (38%), Gaps = 13/141 (9%)

Query: 6   QKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGT 65
           QK A    P + A+A++     S  +S   S   E     E+K    GS +     A GT
Sbjct: 495 QKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEE-----EEKLKGKGSPRPQAPKANGT 549

Query: 66  ASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK 125
           ++ T   A +G  +K+S     E K       K       S+   K+++  K  E  + K
Sbjct: 550 SALT---AQNGKAAKNSEEEEEEKKKAAVVVSKSG-----SLKKRKQNEAAKEAETPQAK 601

Query: 126 SLPKQASDTGSNDAHNKKAVS 146
            +  Q  +T       +K  S
Sbjct: 602 KIKLQTPNTFPKRKKGEKRAS 622


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 120/620 (19%), Positives = 226/620 (36%), Gaps = 89/620 (14%)

Query: 104 KLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTK 163
           K  +  +K  ++ KP+   + K   K+           +K   ++  ++  EK  +P+TK
Sbjct: 140 KKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETK 199

Query: 164 P---QDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDD 220
               +   +   E     T    K G ++K K++      V+  P KP  K   + A   
Sbjct: 200 TLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAA-- 257

Query: 221 LIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAI 280
                       E+   Y        +      + G+     PP   E  ++P     A+
Sbjct: 258 --------VSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPAL 309

Query: 281 DALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALE 340
           +    +          KK EK+ ++E  K +           ++ K+K EK+T  D   +
Sbjct: 310 EEKEGE---------KKKAEKKVTSETKKKEK----------EDIKKKSEKETAIDVEKK 350

Query: 341 ALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPL 400
               +  T+Q   ++  ++  + DE K   +K +K        P+E        ++ K  
Sbjct: 351 EPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKK--------PAEVEQPKGKKQEKKEK 402

Query: 401 LPEPEEKPKPRSESELIDELSEDFDRS-ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTS 459
             EP + PK         E S   D+  + K + +K        K A P    E   +T 
Sbjct: 403 HVEPAKSPK--------KEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTV 454

Query: 460 MCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLG 519
              I+         K       ++      GK+E  P   K   +K  E  K+E   K G
Sbjct: 455 EQEIRKE-------KSGKTSSILKDKEPIKGKEEKVPASLK---EKEPETKKDEKMSKAG 504

Query: 520 EKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFE 579
           ++ +  PP  +L+  K++  +P + KE+K   P +SE   +    +D   P+   S    
Sbjct: 505 KEVKPKPP--QLQGKKEEKPEPQIKKEAK---PAISEKVQIH--KQDIVKPEKTVSHGKP 557

Query: 580 DAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPM 639
           + K       V+ Q  A T +  A P+ T +++       ++   S+   +P P      
Sbjct: 558 EEK-------VLKQVKAVTIEKTAKPKPTKKAEH-----REREPPSIKTDKPKPTPKGTS 605

Query: 640 EDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPI 699
           E     K K E    + E++     + +HL ++    +           ++KPA      
Sbjct: 606 EVTESGKKKTE----ISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPA------ 655

Query: 700 DALSGDLDSCPSTTETSQNT 719
             +S D++  P++ +  + T
Sbjct: 656 -RVSKDVEDVPASKKAKEGT 674



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 139/606 (22%), Positives = 230/606 (37%), Gaps = 98/606 (16%)

Query: 7   KPAASPRPRRAAAARRTH-------EHVSEKTSESPSKPGEKKGSDEKK----AASLGSS 55
           K     +P R    + TH       E V EK  E P K    K   EKK      +L   
Sbjct: 147 KTEKQEKPERKIQTKVTHKEKEKGKEKVREK--EKPEKKATHKEKIEKKEKPETKTLAKE 204

Query: 56  QSSRTYAGGTASATKVSASSGATS--KSSSMNPTETKAVKTEPEKKSQSTKLSV-VHEKK 112
           Q     A  +   TK     G     K ++    E +   ++P++K    K +V  HE+K
Sbjct: 205 QKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQK 264

Query: 113 SQ------------EGKPKEHTEPKSLPKQASDTGSNDAHNKKAV-SRSAEQQPSEK--S 157
            Q             G  K    P   P   ++  S       A+  +  E++ +EK  +
Sbjct: 265 DQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVT 324

Query: 158 TEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKK-SLTPAVPVESKPDKPSGKSGMDA 216
           +E K K ++ I    E    I     +PG   + K+ ++  A    +K D+    S    
Sbjct: 325 SETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTK 384

Query: 217 ALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGP 276
              ++    G  +E +E++         +P  S       K+E ++P   +++ AK    
Sbjct: 385 KPAEVEQPKGKKQEKKEKHV--------EPAKSP------KKEHSVPSD-KQVKAKTERA 429

Query: 277 DDAIDALSSDFTCGSPTAAGKKTEKEEST---EVLKAQSAGTVRSAAPPQEKKRKVEKDT 333
            + I A+S           GKK EK   T   E+ K +S  T       +  K K EK  
Sbjct: 430 KEEIGAVSI-----KKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEK-- 482

Query: 334 MSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPAT 393
                   + ASL  ++ E + D +  K   E K K  +L+  G+ +E      + +P  
Sbjct: 483 --------VPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQ--GKKEE------KPEPQI 526

Query: 394 DKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSE 453
            K+ KP + E     K +   + I +  +     + +EK  K  +     K A P P  +
Sbjct: 527 KKEAKPAISE-----KVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKK 581

Query: 454 AVCR-TSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKE 512
           A  R     SI++  P+P T KGT   +  E+     GKK+ +  + +    K K   K 
Sbjct: 582 AEHREREPPSIKTDKPKP-TPKGT--SEVTES-----GKKKTEISEKE---SKEKADMKH 630

Query: 513 EDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQN 572
              EK+  ++E++    +L  V  K  KP    +  E +P   +       +ED S  + 
Sbjct: 631 LREEKVSTRKESL----QLHNV-TKAEKPARVSKDVEDVPASKK---AKEGTEDVSPTKQ 682

Query: 573 ASSLKF 578
            S + F
Sbjct: 683 KSPISF 688



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 88/433 (20%), Positives = 158/433 (36%), Gaps = 81/433 (18%)

Query: 3   QPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYA 62
           +PGQ PA  P      A+R T    + +  E   K  EKK + E K       +      
Sbjct: 283 KPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKE 342

Query: 63  GGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTK--LSVVHEKKSQEGKPKE 120
                  K    +  T + +     +  A K E ++ S+ TK    V   K  ++ K ++
Sbjct: 343 TAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEK 402

Query: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180
           H EP   PK+                      PS+K  + KT+         E +  ++ 
Sbjct: 403 HVEPAKSPKKEHSV------------------PSDKQVKAKTE------RAKEEIGAVSI 438

Query: 181 ISGKPGDK------------KKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGP 228
               PG K            +KEK   T ++  + +P K   +  + A+L +       P
Sbjct: 439 KKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIK-GKEEKVPASLKE-----KEP 492

Query: 229 EETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFT 288
           E  ++E  +  G EV            GK+E    P+ ++  AKP    + +     D  
Sbjct: 493 ETKKDEKMSKAGKEVKPKPPQLQ----GKKEEKPEPQIKK-EAKP-AISEKVQIHKQDIV 546

Query: 289 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKR-----------KVEKDTMSDQ 337
               T +  K E+    +VLK   A T+   A P+  K+           K +K   + +
Sbjct: 547 KPEKTVSHGKPEE----KVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPK 602

Query: 338 ALEALSAS------LGTRQAEPELDLRSIKEVDEAKAKE----------EKLEKCGEDDE 381
               ++ S      +  ++++ + D++ ++E   +  KE          EK  +  +D E
Sbjct: 603 GTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVE 662

Query: 382 TIPSEYRLKPATD 394
            +P+  + K  T+
Sbjct: 663 DVPASKKAKEGTE 675



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 65/307 (21%), Positives = 110/307 (35%), Gaps = 59/307 (19%)

Query: 472 TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRL 531
           T KG + +  +        K E   +  + +  KV  K KE+ +EK+ EKE+        
Sbjct: 128 TDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHK 187

Query: 532 EEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVV 591
           E+++ K+ KP     +KEQ    + +   +   ++  G       K E  K  AA  + V
Sbjct: 188 EKIEKKE-KPETKTLAKEQKKAKTAEKSEEKTKKEVKGG------KQEKVKQTAAKVKEV 240

Query: 592 SQTPASTTQAGAPPRDTSQSDKDLD---------------DALDKLSDSLGQRQPDPDEN 636
            +TP+   +     +      +  D               D     S ++    P    +
Sbjct: 241 QKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS 300

Query: 637 KP------MEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK--SED 688
           +P      +E+K  EK KAE                          K V   TKK   ED
Sbjct: 301 RPTPASPALEEKEGEKKKAE--------------------------KKVTSETKKKEKED 334

Query: 689 SKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTE 748
            KK ++ +  ID    +       +ET Q T K   + AA   +  ++  K K  A+  +
Sbjct: 335 IKKKSEKETAIDV---EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQ 391

Query: 749 ETSKPKD 755
              K ++
Sbjct: 392 PKGKKQE 398


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 101/401 (25%), Positives = 155/401 (38%), Gaps = 65/401 (16%)

Query: 294 AAGKKTEKEESTEVLKAQSAGTVRSAAPP-------------QEKKRKVEKDTMSDQALE 340
           AA +K E+ E+ E   A     V++ AP              QE++ + ++   SDQA E
Sbjct: 491 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 550

Query: 341 ALSASLGT------RQAEPELDLRSIKEVDEAK---AKEEKLEKCGEDDETIPSEYRLKP 391
             S   G+       Q E E +  +  E  EAK     EEK E+    +E +      KP
Sbjct: 551 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 610

Query: 392 ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE-ESKAAAPAP 450
              K   P  P  E+   P  +S + ++      +S  +EK   P  K+  E K  +P  
Sbjct: 611 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV- 669

Query: 451 VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD--SLGKKEADPEDGKPVMDKVKE 508
                         S  P     K  VP   VE       +GK E   E+ K    +VKE
Sbjct: 670 --------------SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK----EVKE 711

Query: 509 KAKEEDREKLGEKEETIPPDYRLEE-VKD----------KDGKPLLPKESKEQLPPMSED 557
             KEE  EK  EK + +P   + E  VK+          K  K  L KE+KE+  P+ ++
Sbjct: 712 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 771

Query: 558 FLLDAL-----SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSD 612
              +       SE+    + A   + ED  +   + E   +    T + G+      +  
Sbjct: 772 KEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV-EGKEEVEQETKEKGS---GREEEK 827

Query: 613 KDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 653
             + + LD LS +  ++  D  E K +  K  EK  +E  D
Sbjct: 828 GVVTNGLD-LSPADEKKGGDKSEEKVVVTKTVEKITSEGGD 867



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 89/391 (22%), Positives = 138/391 (35%), Gaps = 52/391 (13%)

Query: 281 DALSSDFTCGSPTAAGKKTEKEESTE--VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQA 338
           D L+         AA +K  + E T          G + +  PP     K++K  +    
Sbjct: 386 DLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPK 445

Query: 339 LEAL---------SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 389
           L+              +   ++E E  L +I E      KEEK E   E +E   +E   
Sbjct: 446 LKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE 505

Query: 390 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK---------- 439
             A     K   PE +E+   + E E  +E  E+ + ++  +     +EK          
Sbjct: 506 VAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE 565

Query: 440 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDG 499
            EE +  A A   EA  +     ++    E AT +  V D  VE       +K   P   
Sbjct: 566 QEEGETEAEAEGEEAEAKEEK-KVEEKSEEVATKEELVADAKVEK-----PEKAKSPVPK 619

Query: 500 KPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFL 559
            PV +K K    +   E   EK ++  P   +EE K K   P  P E K + P       
Sbjct: 620 SPVEEKGKSPVPKSPVE---EKGKSPVPKSPVEE-KGKSPVPKSPVEEKGKSPVSK---- 671

Query: 560 LDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDAL 619
              + E    P   S +  E+AK  A + +   Q      +    P++     K+     
Sbjct: 672 -SPVEEKAKSPVPKSPV--EEAKSKAEVGK-GEQKEEEEKEVKEAPKEEKVEKKE----- 722

Query: 620 DKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 650
                   ++  D  E K  E  VKE+A AE
Sbjct: 723 --------EKPKDVPEKKKAESPVKEEAVAE 745



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 94/410 (22%), Positives = 149/410 (36%), Gaps = 69/410 (16%)

Query: 69  TKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVH----EKKSQEGKPKEHTEP 124
           T ++     + K       E K  + E E++  + K S V     E K +EG+ +E  E 
Sbjct: 474 TAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEE--EE 531

Query: 125 KSLPKQASDTGSNDAHNKKAVSRSAEQQPSEK---------------------STEPKTK 163
               ++  D G        A S  AE+  SEK                       E + K
Sbjct: 532 GQEEEEEEDEG--------AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK 583

Query: 164 PQDMISAGGESVAGITAISGKPGDKKKEK-KSLTPAVPVESKPDKPSGKSGMDAALDDLI 222
            +  +    E VA    +      +K EK KS  P  PVE K   P  KS ++      +
Sbjct: 584 EEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 643

Query: 223 DTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDA 282
                P+   EE       +   P+  + +EE GK  V+  P   E  AK   P   ++ 
Sbjct: 644 -----PKSPVEE-------KGKSPVPKSPVEEKGKSPVSKSPV--EEKAKSPVPKSPVEE 689

Query: 283 LSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEAL 342
             S    G      K+ E++E  E  K +             +K+K E     +   E +
Sbjct: 690 AKSKAEVGK--GEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVV 747

Query: 343 SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGED--DETIPSEYRLKPATDKD---- 396
           +    T+  +  L+ +  KE  +   +E++ EK G +   E   S+   K +  +D    
Sbjct: 748 TI---TKSVKVHLE-KETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVN 803

Query: 397 ----GKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEE 442
               GK  + E E K K     E    ++   D S   EK  K  +K+EE
Sbjct: 804 GEVEGKEEV-EQETKEKGSGREEEKGVVTNGLDLSPADEK--KGGDKSEE 850



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 46/221 (20%), Positives = 74/221 (33%), Gaps = 17/221 (7%)

Query: 4   PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAG 63
           P  K     +           E    K+ ++     EK+GS EK+       ++     G
Sbjct: 518 PEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEG 577

Query: 64  GTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEK------------ 111
             A A +       + + ++       A   +PEK       S V EK            
Sbjct: 578 EEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 637

Query: 112 KSQEGKPKEHTEPKS---LPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMI 168
           K +   PK   E K    +PK   +       +K  V   A + P  KS   + K +  +
Sbjct: 638 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKA-KSPVPKSPVEEAKSKAEV 696

Query: 169 SAGGESVAGITAISGKPGDKKKEKKSLTPA-VPVESKPDKP 208
             G +       +   P ++K EKK   P  VP + K + P
Sbjct: 697 GKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESP 737



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 77/380 (20%), Positives = 133/380 (35%), Gaps = 46/380 (12%)

Query: 25  EHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSM 84
           E V+ K S   +   E K  + +K    G  +      G  +   +   S    S     
Sbjct: 504 EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 563

Query: 85  NPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKS---LPKQASDTGSNDAHN 141
              E    + E E +    K     E+KS+E   KE     +    P++A          
Sbjct: 564 GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVE 623

Query: 142 KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 201
           +K  S   +    EK   P   P+  +   G+S      +   P ++K   KS     PV
Sbjct: 624 EKGKSPVPKSPVEEKGKSP--VPKSPVEEKGKS-----PVPKSPVEEK--GKSPVSKSPV 674

Query: 202 ESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVT 261
           E K   P  KS ++ A       +G  E+ EEE                      ++EV 
Sbjct: 675 EEKAKSPVPKSPVEEAKSKA--EVGKGEQKEEE----------------------EKEVK 710

Query: 262 IPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP 321
             PK  ++  K   P D  +   ++    SP       E    T+ +K       +    
Sbjct: 711 EAPKEEKVEKKEEKPKDVPEKKKAE----SPVKEEAVAEVVTITKSVKVHLEKETKEEGK 766

Query: 322 PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCG---- 377
           P +++++ EK    +   E   +  G + +  E D+    EV+  +  E++ ++ G    
Sbjct: 767 PLQQEKEKEK-AGGEGGSEEEGSDKGAKGSRKE-DIAVNGEVEGKEEVEQETKEKGSGRE 824

Query: 378 EDDETIPSEYRLKPATDKDG 397
           E+   + +   L PA +K G
Sbjct: 825 EEKGVVTNGLDLSPADEKKG 844


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 101/401 (25%), Positives = 155/401 (38%), Gaps = 65/401 (16%)

Query: 294 AAGKKTEKEESTEVLKAQSAGTVRSAAPP-------------QEKKRKVEKDTMSDQALE 340
           AA +K E+ E+ E   A     V++ AP              QE++ + ++   SDQA E
Sbjct: 115 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174

Query: 341 ALSASLGT------RQAEPELDLRSIKEVDEAK---AKEEKLEKCGEDDETIPSEYRLKP 391
             S   G+       Q E E +  +  E  EAK     EEK E+    +E +      KP
Sbjct: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234

Query: 392 ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE-ESKAAAPAP 450
              K   P  P  E+   P  +S + ++      +S  +EK   P  K+  E K  +P  
Sbjct: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV- 293

Query: 451 VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD--SLGKKEADPEDGKPVMDKVKE 508
                         S  P     K  VP   VE       +GK E   E+ K    +VKE
Sbjct: 294 --------------SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK----EVKE 335

Query: 509 KAKEEDREKLGEKEETIPPDYRLEE-VKD----------KDGKPLLPKESKEQLPPMSED 557
             KEE  EK  EK + +P   + E  VK+          K  K  L KE+KE+  P+ ++
Sbjct: 336 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 395

Query: 558 FLLDAL-----SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSD 612
              +       SE+    + A   + ED  +   + E   +    T + G+      +  
Sbjct: 396 KEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV-EGKEEVEQETKEKGS---GREEEK 451

Query: 613 KDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 653
             + + LD LS +  ++  D  E K +  K  EK  +E  D
Sbjct: 452 GVVTNGLD-LSPADEKKGGDKSEEKVVVTKTVEKITSEGGD 491



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 89/391 (22%), Positives = 138/391 (35%), Gaps = 52/391 (13%)

Query: 281 DALSSDFTCGSPTAAGKKTEKEESTE--VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQA 338
           D L+         AA +K  + E T          G + +  PP     K++K  +    
Sbjct: 10  DLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPK 69

Query: 339 LEAL---------SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 389
           L+              +   ++E E  L +I E      KEEK E   E +E   +E   
Sbjct: 70  LKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE 129

Query: 390 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK---------- 439
             A     K   PE +E+   + E E  +E  E+ + ++  +     +EK          
Sbjct: 130 VAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE 189

Query: 440 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDG 499
            EE +  A A   EA  +     ++    E AT +  V D  VE       +K   P   
Sbjct: 190 QEEGETEAEAEGEEAEAKEEK-KVEEKSEEVATKEELVADAKVEK-----PEKAKSPVPK 243

Query: 500 KPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFL 559
            PV +K K    +   E   EK ++  P   +EE K K   P  P E K + P       
Sbjct: 244 SPVEEKGKSPVPKSPVE---EKGKSPVPKSPVEE-KGKSPVPKSPVEEKGKSPVSK---- 295

Query: 560 LDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDAL 619
              + E    P   S +  E+AK  A + +   Q      +    P++     K+     
Sbjct: 296 -SPVEEKAKSPVPKSPV--EEAKSKAEVGK-GEQKEEEEKEVKEAPKEEKVEKKE----- 346

Query: 620 DKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 650
                   ++  D  E K  E  VKE+A AE
Sbjct: 347 --------EKPKDVPEKKKAESPVKEEAVAE 369



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 94/410 (22%), Positives = 149/410 (36%), Gaps = 69/410 (16%)

Query: 69  TKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVH----EKKSQEGKPKEHTEP 124
           T ++     + K       E K  + E E++  + K S V     E K +EG+ +E  E 
Sbjct: 98  TAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEE--EE 155

Query: 125 KSLPKQASDTGSNDAHNKKAVSRSAEQQPSEK---------------------STEPKTK 163
               ++  D G        A S  AE+  SEK                       E + K
Sbjct: 156 GQEEEEEEDEG--------AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK 207

Query: 164 PQDMISAGGESVAGITAISGKPGDKKKEK-KSLTPAVPVESKPDKPSGKSGMDAALDDLI 222
            +  +    E VA    +      +K EK KS  P  PVE K   P  KS ++      +
Sbjct: 208 EEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 267

Query: 223 DTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDA 282
                P+   EE       +   P+  + +EE GK  V+  P   E  AK   P   ++ 
Sbjct: 268 -----PKSPVEE-------KGKSPVPKSPVEEKGKSPVSKSPV--EEKAKSPVPKSPVEE 313

Query: 283 LSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEAL 342
             S    G      K+ E++E  E  K +             +K+K E     +   E +
Sbjct: 314 AKSKAEVGK--GEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVV 371

Query: 343 SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGED--DETIPSEYRLKPATDKD---- 396
           +    T+  +  L+ +  KE  +   +E++ EK G +   E   S+   K +  +D    
Sbjct: 372 TI---TKSVKVHLE-KETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVN 427

Query: 397 ----GKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEE 442
               GK  + E E K K     E    ++   D S   EK  K  +K+EE
Sbjct: 428 GEVEGKEEV-EQETKEKGSGREEEKGVVTNGLDLSPADEK--KGGDKSEE 474



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 46/221 (20%), Positives = 74/221 (33%), Gaps = 17/221 (7%)

Query: 4   PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAG 63
           P  K     +           E    K+ ++     EK+GS EK+       ++     G
Sbjct: 142 PEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEG 201

Query: 64  GTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEK------------ 111
             A A +       + + ++       A   +PEK       S V EK            
Sbjct: 202 EEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 261

Query: 112 KSQEGKPKEHTEPKS---LPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMI 168
           K +   PK   E K    +PK   +       +K  V   A + P  KS   + K +  +
Sbjct: 262 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKA-KSPVPKSPVEEAKSKAEV 320

Query: 169 SAGGESVAGITAISGKPGDKKKEKKSLTPA-VPVESKPDKP 208
             G +       +   P ++K EKK   P  VP + K + P
Sbjct: 321 GKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESP 361



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 77/380 (20%), Positives = 133/380 (35%), Gaps = 46/380 (12%)

Query: 25  EHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSM 84
           E V+ K S   +   E K  + +K    G  +      G  +   +   S    S     
Sbjct: 128 EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 187

Query: 85  NPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKS---LPKQASDTGSNDAHN 141
              E    + E E +    K     E+KS+E   KE     +    P++A          
Sbjct: 188 GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVE 247

Query: 142 KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 201
           +K  S   +    EK   P   P+  +   G+S      +   P ++K   KS     PV
Sbjct: 248 EKGKSPVPKSPVEEKGKSP--VPKSPVEEKGKS-----PVPKSPVEEK--GKSPVSKSPV 298

Query: 202 ESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVT 261
           E K   P  KS ++ A       +G  E+ EEE                      ++EV 
Sbjct: 299 EEKAKSPVPKSPVEEAKSKA--EVGKGEQKEEE----------------------EKEVK 334

Query: 262 IPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP 321
             PK  ++  K   P D  +   ++    SP       E    T+ +K       +    
Sbjct: 335 EAPKEEKVEKKEEKPKDVPEKKKAE----SPVKEEAVAEVVTITKSVKVHLEKETKEEGK 390

Query: 322 PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCG---- 377
           P +++++ EK    +   E   +  G + +  E D+    EV+  +  E++ ++ G    
Sbjct: 391 PLQQEKEKEK-AGGEGGSEEEGSDKGAKGSRKE-DIAVNGEVEGKEEVEQETKEKGSGRE 448

Query: 378 EDDETIPSEYRLKPATDKDG 397
           E+   + +   L PA +K G
Sbjct: 449 EEKGVVTNGLDLSPADEKKG 468


>gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
            sapiens]
          Length = 1782

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 145/699 (20%), Positives = 262/699 (37%), Gaps = 117/699 (16%)

Query: 28   SEKTSESPSKPGEKK-GSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNP 86
            + + S S  + G K  G D +KA   G  + + T  G  A + +     G++S   + +P
Sbjct: 692  ARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGT-DGILAGSQEHDPGQGSSSPEQAGSP 750

Query: 87   TETKAVKT--------EPEKKSQSTKLSVVHEKKSQE---GKPKEHTEPKSLPKQASDTG 135
            TE + V T         P KKS+S KL    E+KS++   G   EH+ P + P +     
Sbjct: 751  TEGEGVSTWESFKRLVTPRKKSKS-KL----EEKSEDSIAGSGVEHSTPDTEPGKEESWV 805

Query: 136  SND----AHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKE 191
            S         KK      EQ P E +        D        ++   A+  +  + ++ 
Sbjct: 806  SIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQA 865

Query: 192  KKSLT-PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPM--- 247
            +KS   P     ++  K   +S +      + D        EE + ++    V++P+   
Sbjct: 866  QKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQV 925

Query: 248  ---SSTYIEELGKREVTI---PPKYRELL---------------------------AKPI 274
               ++   EE+ +REV     PP   E L                           A P+
Sbjct: 926  EAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPL 985

Query: 275  GPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTM 334
            G ++  +A +++ T    +A  + T+  ++TE  +A     V    P  E++ +  ++ +
Sbjct: 986  GAEEGTEASAAEETTEMVSAVSQLTDSPDTTE--EATPVQEVEGGVPDIEEQERRTQEVL 1043

Query: 335  SDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATD 394
               A +    S       PE  L+ ++   EA+  EE+ E  G           LK  TD
Sbjct: 1044 QAVAEKVKEESQLPGTGGPEDVLQPVQRA-EAERPEEQAEASG-----------LKKETD 1091

Query: 395  KDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEA 454
               K  +   E K +P ++ +++ + +      E  EK  + TE  E          SE 
Sbjct: 1092 VVLK--VDAQEAKTEPFTQGKVVGQTT-----PESFEKAPQVTESIES---------SEL 1135

Query: 455  VCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPED----GKPVMDKVKEKA 510
            V      ++     +   ++  +P D+VE   DS         D    G    D++ E  
Sbjct: 1136 VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIH 1195

Query: 511  KEED----REKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ------LPPMSEDFLL 560
            +E +     +  G + E +P     +E        +  +E+KEQ      L    ++  +
Sbjct: 1196 EENEVASGTQSGGTEAEAVPAQ---KERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSV 1252

Query: 561  DALS--EDFSGPQNASSLKFEDAK-------LAAAISEVVSQTPASTTQAGAPPRDTSQS 611
            + +S      G Q A     E  K       L  +I   ++ +    T+       T ++
Sbjct: 1253 ETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEA 1312

Query: 612  DKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 650
            +   DDAL+  S +  +  P P E + +    +EK +AE
Sbjct: 1313 ECKKDDALELQSHA--KSPPSPVEREMVVQVEREKTEAE 1349



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 119/697 (17%), Positives = 259/697 (37%), Gaps = 78/697 (11%)

Query: 2   SQPGQKPAASPRPRRAAAARRTHEHVSEKTS-----ESPSKPGEKKGSDEKKAASLGSSQ 56
           S+  +   ++ +P       ++H  +S         E   + GE+K   E   ++   + 
Sbjct: 227 SKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTS 286

Query: 57  SSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKK---- 112
              +  G T         +G   K+S   P E +   +E +K+ +  K+    + K    
Sbjct: 287 PVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVA 346

Query: 113 ------SQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRS---AEQQPSEKSTEPKTK 163
                 S++  P+E  E    P+ +++    +  +++ VS S   +E++P+  +TE   +
Sbjct: 347 SEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDE 406

Query: 164 PQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLID 223
             ++      +   ++ +  +  ++K E +    +VP E                 +L++
Sbjct: 407 KIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE-----------------ELVE 449

Query: 224 TLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDAL 283
               P+E E         E+     +    E   +   + P  + L   P G    ++ L
Sbjct: 450 MDAEPQEAE------PAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEML 503

Query: 284 SSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALS 343
           SS           ++  K + + + K  ++  ++  +  ++K ++   D  S +  +  +
Sbjct: 504 SS-----------QERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPA 552

Query: 344 ASLGTRQAEP-ELDLRSIKEVDEAKAKEEKLEKCGEDDE-----TIPSEYRLKPATDKDG 397
            S  +++ +  E    S +E +E    E+ L +  +D E     T   E + +  T    
Sbjct: 553 DSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWAS 612

Query: 398 KPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAP------- 450
              +  P+++ +  SES+  DEL +    +      S  +E  EE K +   P       
Sbjct: 613 FKKMVTPKKRVRRPSESDKEDEL-DKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKR 671

Query: 451 -VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEK 509
            V  +V   ++  + S+         +  +   +A+     K +   +D +   D +   
Sbjct: 672 KVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAG 731

Query: 510 AKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL---PKESKEQLPPMSEDFLLDALSED 566
           ++E D  +     E        E V   +    L    K+SK +L   SED +  +   +
Sbjct: 732 SQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGS-GVE 790

Query: 567 FSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD----ALDKL 622
            S P      +     +   I     + P    Q  AP  D   +  + DD    A+  L
Sbjct: 791 HSTPDTEPGKEESWVSIKKFIPGRRKKRP-DGKQEQAPVEDAGPTGANEDDSDVPAVVPL 849

Query: 623 S--DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGE 657
           S  D++ + + +  + +   ++ ++KA  E   +L E
Sbjct: 850 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSE 886



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 151/812 (18%), Positives = 289/812 (35%), Gaps = 125/812 (15%)

Query: 8    PAASPRPRRAAAARRTHEHVS--EKTSESPSKPGEKKGSDEKKAASLG-SSQSSRTYAGG 64
            P  +     A+AA  T E VS   + ++SP    E     E +        Q  RT    
Sbjct: 984  PLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVL 1043

Query: 65   TASATKVSASS---GATSKSSSMNPTETKAVKTEPEKKSQSTKLS----VVHEKKSQEGK 117
             A A KV   S   G       + P + +A    PE++++++ L     VV +  +QE K
Sbjct: 1044 QAVAEKVKEESQLPGTGGPEDVLQPVQ-RAEAERPEEQAEASGLKKETDVVLKVDAQEAK 1102

Query: 118  PKEHTE--------PKSLPKQASDTGSNDAHN--------------------KKAVSRSA 149
             +  T+        P+S  K    T S ++                      ++A+   +
Sbjct: 1103 TEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDS 1162

Query: 150  EQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPS 209
             + P++  T+  T   D  + G      I  I  +       +   T A  V ++ ++P 
Sbjct: 1163 VETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPP 1222

Query: 210  GKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYREL 269
              S        +       +   E+   +T  EVS    S   +  G +E     +Y + 
Sbjct: 1223 APSSF------VFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEAD---QYADE 1273

Query: 270  LAKPIGPDDAIDALSSDFTCGSPTAAGKKTE---KEESTEVLKAQSAGTVR----SAAPP 322
              K +      + L      G   +  K TE   K E TE  + +    +     + +PP
Sbjct: 1274 KTKDV---PFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPP 1330

Query: 323  -----------QEKKRKVEKDTMSDQALEALSASLGTRQAEPEL----DLRSIKEVDEAK 367
                       + +K + E   ++++ LE  +A   + +   +L    ++  I    E  
Sbjct: 1331 SPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVS 1390

Query: 368  AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 427
            + E     C   +E + ++ +++ +   +    L    E+ K   E+  I E  E  + +
Sbjct: 1391 SLEGSPPPCLGQEEAVCTKIQVQSS---EASFTLTAAAEEEKVLGETANILETGETLEPA 1447

Query: 428  ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP-EPATLKGTVPDDAVEALA 486
                   + + +  E  AA P    +AV     C  +S P    AT K  +  D      
Sbjct: 1448 GAHLVLEEKSSEKNEDFAAHPG--EDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKT 1505

Query: 487  DSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE 546
             SL K ++D  D +    +VK     ED E          P+  + E++ K  K      
Sbjct: 1506 TSL-KWKSDEVDEQVACQEVKVSVAIEDLE----------PENGILELETKSSK------ 1548

Query: 547  SKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQA-GAPP 605
                   + ++ +  A+ +     + A+ +   + +  A + +  SQ     T+  G  P
Sbjct: 1549 -------LVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEP 1601

Query: 606  RDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMED------------------KVKEKA 647
            + ++Q +  +  A ++ S+S    Q   D +K M +                  +++E  
Sbjct: 1602 QASAQDETPITSAKEE-SESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVV 1660

Query: 648  KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 707
                 +  G    ++P +  H L     +K +  P  K ++     DD +  ++   D D
Sbjct: 1661 LPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEP--KEDEKGDDVDDPENQNSALADTD 1718

Query: 708  SCPSTTETSQNTAKDKCKKAASSSKAPKNGGK 739
            +    T+ S +T   K K+   + +     GK
Sbjct: 1719 ASGGLTKESPDTNGPKQKEKEDAQEVELQEGK 1750



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 147/734 (20%), Positives = 237/734 (32%), Gaps = 117/734 (15%)

Query: 72  SASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQA 131
           +AS  +  K S+  P ET   +    + S   +     E+  +EG+ K+  EP       
Sbjct: 225 AASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEP------- 277

Query: 132 SDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKE 191
                         S+SAE   S  ++E  +  +   + G       T+       K KE
Sbjct: 278 --------------SKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFR-----KPKE 318

Query: 192 KKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTY 251
            +        E +P+K      +D   D      G  E   E+ T        +P  S +
Sbjct: 319 DEVEASEKKKEQEPEK------VDTEED------GKAEVASEKLTASEQAHPQEPAESAH 366

Query: 252 IEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEE--STEVLK 309
              L      +     E ++   GP +   A         P A     EK E    EV+ 
Sbjct: 367 EPRLSAEYEKVELPSEEQVSGSQGPSEEKPA---------PLATEVFDEKIEVHQEEVVA 417

Query: 310 AQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEV------ 363
                TV      +E+K +VE+   S  A E +      ++AEP  +L  +KE       
Sbjct: 418 EVHVSTVEERT--EEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGED 475

Query: 364 --------DEAKAKEEKLEKCGEDDETIPSEYR-------LKPATDKDGKPLLPEPEEKP 408
                    + K   +  E    + E + S+ R       LK      G   L   ++K 
Sbjct: 476 PTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKG 535

Query: 409 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVC-RTSMCSIQ--S 465
           K     E   E ++        + P    E+  ES A++P    E  C    +  +Q   
Sbjct: 536 KRGGGDEESGEHTQ-----VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDG 590

Query: 466 APPEPATLKGTVPDDAVEALADSLGKKEADPE---------DGKPVMDKVK--------E 508
              E AT  G    + V   A    KK   P+         D +  +DKVK         
Sbjct: 591 EAEEGATSDGEKKREGVTPWASF--KKMVTPKKRVRRPSESDKEDELDKVKSATLSSTES 648

Query: 509 KAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL----PKESKEQLPPMSEDFLLDALS 564
            A E   E  G  EE  P + + +       + L+     K+   +     E+    A+ 
Sbjct: 649 TASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMG 708

Query: 565 EDFSGPQNASSLK--FEDAKLAAAISEVVSQTPASTTQAGAPPR----DTSQSDKDLDDA 618
            D      A   K    D  LA +      Q  +S  QAG+P       T +S K L   
Sbjct: 709 GDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTP 768

Query: 619 LDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKP 678
             K    L ++  D      +E    +    +    +  +   IP   +   D   +  P
Sbjct: 769 RKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIK-KFIPGRRKKRPDGKQEQAP 827

Query: 679 VKP--PTKKSEDSKK-----PADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSS 731
           V+   PT  +ED        P  + D ++    +      + E  +  A  +  K  S S
Sbjct: 828 VEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSES 887

Query: 732 KAPKNGGKAKDSAK 745
           +         D  +
Sbjct: 888 QVHMMAAAVADGTR 901



 Score = 34.3 bits (77), Expect = 0.44
 Identities = 79/353 (22%), Positives = 132/353 (37%), Gaps = 61/353 (17%)

Query: 25   EHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSM 84
            E  SEK  +  + PGE        A   G    +++     ++ TK   SS    + ++ 
Sbjct: 1455 EKSSEKNEDFAAHPGED-------AVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTS 1507

Query: 85   NPTETKAVKTEPEKKSQSTKLSV-VHEKKSQEGKPKEHTEPKSLPKQASDTG-------- 135
               + K+ + + +   Q  K+SV + + + + G  +  T+   L +    T         
Sbjct: 1508 --LKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTE 1565

Query: 136  -----------SNDAHNKKAVSRSAEQQPSEKSTEPKTKPQD---MISAGGESVAGITAI 181
                          AH  KA S+ A Q+  ++  EP+   QD   + SA  ES +  TA+
Sbjct: 1566 ETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESES--TAV 1623

Query: 182  SGKPGDKKK---EKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTY 238
                 D  K   E    T  V VE       G +  D  L++++  L   EE     T  
Sbjct: 1624 GQAHSDISKDMSEASEKTMTVEVE-------GSTVNDQQLEEVV--LPSEEEGGGAGTKS 1674

Query: 239  TGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDAL-----SSDFTCGSPT 293
               +    + +  IE     +  + PK  E       P++   AL     S   T  SP 
Sbjct: 1675 VPEDDGHALLAERIE-----KSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPD 1729

Query: 294  AAG-KKTEKEESTEVL----KAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEA 341
              G K+ EKE++ EV     K  S          QE+ +K E+++   +  E+
Sbjct: 1730 TNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES 1782


>gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
            sapiens]
          Length = 1684

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 145/699 (20%), Positives = 262/699 (37%), Gaps = 117/699 (16%)

Query: 28   SEKTSESPSKPGEKK-GSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNP 86
            + + S S  + G K  G D +KA   G  + + T  G  A + +     G++S   + +P
Sbjct: 594  ARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGT-DGILAGSQEHDPGQGSSSPEQAGSP 652

Query: 87   TETKAVKT--------EPEKKSQSTKLSVVHEKKSQE---GKPKEHTEPKSLPKQASDTG 135
            TE + V T         P KKS+S KL    E+KS++   G   EH+ P + P +     
Sbjct: 653  TEGEGVSTWESFKRLVTPRKKSKS-KL----EEKSEDSIAGSGVEHSTPDTEPGKEESWV 707

Query: 136  SND----AHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKE 191
            S         KK      EQ P E +        D        ++   A+  +  + ++ 
Sbjct: 708  SIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQA 767

Query: 192  KKSLT-PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPM--- 247
            +KS   P     ++  K   +S +      + D        EE + ++    V++P+   
Sbjct: 768  QKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQV 827

Query: 248  ---SSTYIEELGKREVTI---PPKYRELL---------------------------AKPI 274
               ++   EE+ +REV     PP   E L                           A P+
Sbjct: 828  EAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPL 887

Query: 275  GPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTM 334
            G ++  +A +++ T    +A  + T+  ++TE  +A     V    P  E++ +  ++ +
Sbjct: 888  GAEEGTEASAAEETTEMVSAVSQLTDSPDTTE--EATPVQEVEGGVPDIEEQERRTQEVL 945

Query: 335  SDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATD 394
               A +    S       PE  L+ ++   EA+  EE+ E  G           LK  TD
Sbjct: 946  QAVAEKVKEESQLPGTGGPEDVLQPVQRA-EAERPEEQAEASG-----------LKKETD 993

Query: 395  KDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEA 454
               K  +   E K +P ++ +++ + +      E  EK  + TE  E          SE 
Sbjct: 994  VVLK--VDAQEAKTEPFTQGKVVGQTT-----PESFEKAPQVTESIES---------SEL 1037

Query: 455  VCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPED----GKPVMDKVKEKA 510
            V      ++     +   ++  +P D+VE   DS         D    G    D++ E  
Sbjct: 1038 VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIH 1097

Query: 511  KEED----REKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ------LPPMSEDFLL 560
            +E +     +  G + E +P     +E        +  +E+KEQ      L    ++  +
Sbjct: 1098 EENEVASGTQSGGTEAEAVPAQ---KERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSV 1154

Query: 561  DALS--EDFSGPQNASSLKFEDAK-------LAAAISEVVSQTPASTTQAGAPPRDTSQS 611
            + +S      G Q A     E  K       L  +I   ++ +    T+       T ++
Sbjct: 1155 ETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEA 1214

Query: 612  DKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 650
            +   DDAL+  S +  +  P P E + +    +EK +AE
Sbjct: 1215 ECKKDDALELQSHA--KSPPSPVEREMVVQVEREKTEAE 1251



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 119/697 (17%), Positives = 259/697 (37%), Gaps = 78/697 (11%)

Query: 2   SQPGQKPAASPRPRRAAAARRTHEHVSEKTS-----ESPSKPGEKKGSDEKKAASLGSSQ 56
           S+  +   ++ +P       ++H  +S         E   + GE+K   E   ++   + 
Sbjct: 129 SKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTS 188

Query: 57  SSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKK---- 112
              +  G T         +G   K+S   P E +   +E +K+ +  K+    + K    
Sbjct: 189 PVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVA 248

Query: 113 ------SQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRS---AEQQPSEKSTEPKTK 163
                 S++  P+E  E    P+ +++    +  +++ VS S   +E++P+  +TE   +
Sbjct: 249 SEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDE 308

Query: 164 PQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLID 223
             ++      +   ++ +  +  ++K E +    +VP E                 +L++
Sbjct: 309 KIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE-----------------ELVE 351

Query: 224 TLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDAL 283
               P+E E         E+     +    E   +   + P  + L   P G    ++ L
Sbjct: 352 MDAEPQEAE------PAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEML 405

Query: 284 SSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALS 343
           SS           ++  K + + + K  ++  ++  +  ++K ++   D  S +  +  +
Sbjct: 406 SS-----------QERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPA 454

Query: 344 ASLGTRQAEP-ELDLRSIKEVDEAKAKEEKLEKCGEDDE-----TIPSEYRLKPATDKDG 397
            S  +++ +  E    S +E +E    E+ L +  +D E     T   E + +  T    
Sbjct: 455 DSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWAS 514

Query: 398 KPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAP------- 450
              +  P+++ +  SES+  DEL +    +      S  +E  EE K +   P       
Sbjct: 515 FKKMVTPKKRVRRPSESDKEDEL-DKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKR 573

Query: 451 -VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEK 509
            V  +V   ++  + S+         +  +   +A+     K +   +D +   D +   
Sbjct: 574 KVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAG 633

Query: 510 AKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL---PKESKEQLPPMSEDFLLDALSED 566
           ++E D  +     E        E V   +    L    K+SK +L   SED +  +   +
Sbjct: 634 SQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGS-GVE 692

Query: 567 FSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD----ALDKL 622
            S P      +     +   I     + P    Q  AP  D   +  + DD    A+  L
Sbjct: 693 HSTPDTEPGKEESWVSIKKFIPGRRKKRP-DGKQEQAPVEDAGPTGANEDDSDVPAVVPL 751

Query: 623 S--DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGE 657
           S  D++ + + +  + +   ++ ++KA  E   +L E
Sbjct: 752 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSE 788



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 151/812 (18%), Positives = 289/812 (35%), Gaps = 125/812 (15%)

Query: 8    PAASPRPRRAAAARRTHEHVS--EKTSESPSKPGEKKGSDEKKAASLG-SSQSSRTYAGG 64
            P  +     A+AA  T E VS   + ++SP    E     E +        Q  RT    
Sbjct: 886  PLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVL 945

Query: 65   TASATKVSASS---GATSKSSSMNPTETKAVKTEPEKKSQSTKLS----VVHEKKSQEGK 117
             A A KV   S   G       + P + +A    PE++++++ L     VV +  +QE K
Sbjct: 946  QAVAEKVKEESQLPGTGGPEDVLQPVQ-RAEAERPEEQAEASGLKKETDVVLKVDAQEAK 1004

Query: 118  PKEHTE--------PKSLPKQASDTGSNDAHN--------------------KKAVSRSA 149
             +  T+        P+S  K    T S ++                      ++A+   +
Sbjct: 1005 TEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDS 1064

Query: 150  EQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPS 209
             + P++  T+  T   D  + G      I  I  +       +   T A  V ++ ++P 
Sbjct: 1065 VETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPP 1124

Query: 210  GKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYREL 269
              S        +       +   E+   +T  EVS    S   +  G +E     +Y + 
Sbjct: 1125 APSSF------VFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEAD---QYADE 1175

Query: 270  LAKPIGPDDAIDALSSDFTCGSPTAAGKKTE---KEESTEVLKAQSAGTVR----SAAPP 322
              K +      + L      G   +  K TE   K E TE  + +    +     + +PP
Sbjct: 1176 KTKDV---PFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPP 1232

Query: 323  -----------QEKKRKVEKDTMSDQALEALSASLGTRQAEPEL----DLRSIKEVDEAK 367
                       + +K + E   ++++ LE  +A   + +   +L    ++  I    E  
Sbjct: 1233 SPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVS 1292

Query: 368  AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 427
            + E     C   +E + ++ +++ +   +    L    E+ K   E+  I E  E  + +
Sbjct: 1293 SLEGSPPPCLGQEEAVCTKIQVQSS---EASFTLTAAAEEEKVLGETANILETGETLEPA 1349

Query: 428  ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP-EPATLKGTVPDDAVEALA 486
                   + + +  E  AA P    +AV     C  +S P    AT K  +  D      
Sbjct: 1350 GAHLVLEEKSSEKNEDFAAHPG--EDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKT 1407

Query: 487  DSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE 546
             SL K ++D  D +    +VK     ED E          P+  + E++ K  K      
Sbjct: 1408 TSL-KWKSDEVDEQVACQEVKVSVAIEDLE----------PENGILELETKSSK------ 1450

Query: 547  SKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQA-GAPP 605
                   + ++ +  A+ +     + A+ +   + +  A + +  SQ     T+  G  P
Sbjct: 1451 -------LVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEP 1503

Query: 606  RDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMED------------------KVKEKA 647
            + ++Q +  +  A ++ S+S    Q   D +K M +                  +++E  
Sbjct: 1504 QASAQDETPITSAKEE-SESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVV 1562

Query: 648  KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 707
                 +  G    ++P +  H L     +K +  P  K ++     DD +  ++   D D
Sbjct: 1563 LPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEP--KEDEKGDDVDDPENQNSALADTD 1620

Query: 708  SCPSTTETSQNTAKDKCKKAASSSKAPKNGGK 739
            +    T+ S +T   K K+   + +     GK
Sbjct: 1621 ASGGLTKESPDTNGPKQKEKEDAQEVELQEGK 1652



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 147/734 (20%), Positives = 237/734 (32%), Gaps = 117/734 (15%)

Query: 72  SASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQA 131
           +AS  +  K S+  P ET   +    + S   +     E+  +EG+ K+  EP       
Sbjct: 127 AASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEP------- 179

Query: 132 SDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKE 191
                         S+SAE   S  ++E  +  +   + G       T+       K KE
Sbjct: 180 --------------SKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFR-----KPKE 220

Query: 192 KKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTY 251
            +        E +P+K      +D   D      G  E   E+ T        +P  S +
Sbjct: 221 DEVEASEKKKEQEPEK------VDTEED------GKAEVASEKLTASEQAHPQEPAESAH 268

Query: 252 IEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEE--STEVLK 309
              L      +     E ++   GP +   A         P A     EK E    EV+ 
Sbjct: 269 EPRLSAEYEKVELPSEEQVSGSQGPSEEKPA---------PLATEVFDEKIEVHQEEVVA 319

Query: 310 AQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEV------ 363
                TV      +E+K +VE+   S  A E +      ++AEP  +L  +KE       
Sbjct: 320 EVHVSTVEERT--EEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGED 377

Query: 364 --------DEAKAKEEKLEKCGEDDETIPSEYR-------LKPATDKDGKPLLPEPEEKP 408
                    + K   +  E    + E + S+ R       LK      G   L   ++K 
Sbjct: 378 PTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKG 437

Query: 409 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVC-RTSMCSIQ--S 465
           K     E   E ++        + P    E+  ES A++P    E  C    +  +Q   
Sbjct: 438 KRGGGDEESGEHTQ-----VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDG 492

Query: 466 APPEPATLKGTVPDDAVEALADSLGKKEADPE---------DGKPVMDKVK--------E 508
              E AT  G    + V   A    KK   P+         D +  +DKVK         
Sbjct: 493 EAEEGATSDGEKKREGVTPWASF--KKMVTPKKRVRRPSESDKEDELDKVKSATLSSTES 550

Query: 509 KAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL----PKESKEQLPPMSEDFLLDALS 564
            A E   E  G  EE  P + + +       + L+     K+   +     E+    A+ 
Sbjct: 551 TASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMG 610

Query: 565 EDFSGPQNASSLK--FEDAKLAAAISEVVSQTPASTTQAGAPPR----DTSQSDKDLDDA 618
            D      A   K    D  LA +      Q  +S  QAG+P       T +S K L   
Sbjct: 611 GDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTP 670

Query: 619 LDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKP 678
             K    L ++  D      +E    +    +    +  +   IP   +   D   +  P
Sbjct: 671 RKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIK-KFIPGRRKKRPDGKQEQAP 729

Query: 679 VKP--PTKKSEDSKK-----PADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSS 731
           V+   PT  +ED        P  + D ++    +      + E  +  A  +  K  S S
Sbjct: 730 VEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSES 789

Query: 732 KAPKNGGKAKDSAK 745
           +         D  +
Sbjct: 790 QVHMMAAAVADGTR 803



 Score = 34.3 bits (77), Expect = 0.44
 Identities = 79/353 (22%), Positives = 132/353 (37%), Gaps = 61/353 (17%)

Query: 25   EHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSM 84
            E  SEK  +  + PGE        A   G    +++     ++ TK   SS    + ++ 
Sbjct: 1357 EKSSEKNEDFAAHPGED-------AVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTS 1409

Query: 85   NPTETKAVKTEPEKKSQSTKLSV-VHEKKSQEGKPKEHTEPKSLPKQASDTG-------- 135
               + K+ + + +   Q  K+SV + + + + G  +  T+   L +    T         
Sbjct: 1410 --LKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTE 1467

Query: 136  -----------SNDAHNKKAVSRSAEQQPSEKSTEPKTKPQD---MISAGGESVAGITAI 181
                          AH  KA S+ A Q+  ++  EP+   QD   + SA  ES +  TA+
Sbjct: 1468 ETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESES--TAV 1525

Query: 182  SGKPGDKKK---EKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTY 238
                 D  K   E    T  V VE       G +  D  L++++  L   EE     T  
Sbjct: 1526 GQAHSDISKDMSEASEKTMTVEVE-------GSTVNDQQLEEVV--LPSEEEGGGAGTKS 1576

Query: 239  TGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDAL-----SSDFTCGSPT 293
               +    + +  IE     +  + PK  E       P++   AL     S   T  SP 
Sbjct: 1577 VPEDDGHALLAERIE-----KSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPD 1631

Query: 294  AAG-KKTEKEESTEVL----KAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEA 341
              G K+ EKE++ EV     K  S          QE+ +K E+++   +  E+
Sbjct: 1632 TNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES 1684


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 110/746 (14%), Positives = 244/746 (32%), Gaps = 28/746 (3%)

Query: 28   SEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPT 87
            ++   +S S  G+   SD   + S  SS SS +    ++ +   S S  + S SS  + +
Sbjct: 534  NDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDS 593

Query: 88   ETK-----AVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNK 142
            ++      +  ++    S S+  S   + KS   K +  +        +SD+ S+D+ + 
Sbjct: 594  DSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDN 653

Query: 143  KAVSRSAEQQPSEKSTE-----PKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTP 197
               S S+    S  S++       +   D  ++   S +  ++ S +  D      S + 
Sbjct: 654  SDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSS 713

Query: 198  AVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGK 257
                 S  +     S   +   D  ++    + ++  N++ +        SS   +    
Sbjct: 714  DSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDS 773

Query: 258  REVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVR 317
             + +      +        D +  + SSD +  S ++    +   +S+    + ++    
Sbjct: 774  SDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSS 833

Query: 318  SAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCG 377
             ++   +     +    SD      S S  +  +    D  +  +  ++    E      
Sbjct: 834  DSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSD 893

Query: 378  EDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPT 437
              D +         ++D D        +      S        S D   S      S  +
Sbjct: 894  SSDSS--------NSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSS 945

Query: 438  EKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPD--DAVEALADSLGKKEAD 495
            + ++ S ++  +  S++   +      S+    ++      D  D+ ++   S     +D
Sbjct: 946  DSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSD 1005

Query: 496  PEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMS 555
              D     D           +     + +   D   +     D        +       S
Sbjct: 1006 SSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSD-SSDSSDSSDSSDSSDSSNSSDSSDSS 1064

Query: 556  EDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQS--DK 613
            +       S+      ++ S    D+  ++  S+    + +S +   +   D+S S    
Sbjct: 1065 DSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSS 1124

Query: 614  DLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLD-D 672
            D  D+ D    S      D  ++    D       ++  D     D +   +  +  D  
Sbjct: 1125 DSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSS 1184

Query: 673  NGQDKPVKPPTKKSEDSKKPADDQDPIDA--LSGDLDSCPSTTETSQNTAKDKCKKAASS 730
            +  D      +  S DS   +D  D  D+   S   DS  S+  +  N + D    + SS
Sbjct: 1185 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSS 1244

Query: 731  SKAPKNGGKAKDSAKTTEETSKPKDD 756
              +  N   + DS+ +++ TS   D+
Sbjct: 1245 DSS--NSSDSSDSSDSSDSTSDSNDE 1268



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 109/723 (15%), Positives = 227/723 (31%), Gaps = 38/723 (5%)

Query: 28   SEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPT 87
            S  +S+S         SD K  +S   S SS + +   +S +  S SS  +  S S N +
Sbjct: 604  SSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSS 663

Query: 88   ETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSR 147
             +       +    S+     +   S +     ++   S    +SD+ S+D+      S 
Sbjct: 664  NSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDS------SD 717

Query: 148  SAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDK 207
            S+    S+  +   +   D  ++   S +  ++ S    D      S   +   +S    
Sbjct: 718  SSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSS 777

Query: 208  PSGKSGMDAALDDLIDTLGGPEETEEENTTYT--GPEVSDPMSSTYIEELGKREVTIPPK 265
             S  S       +  D+      ++  N++ +    + SD  SS   +     +      
Sbjct: 778  DSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSD------ 831

Query: 266  YRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEK 325
                 +      D+ D  SSD + GS + +  +++   S++   +  +     ++   + 
Sbjct: 832  ----SSDSSNSSDSSD--SSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDS 885

Query: 326  KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPS 385
                     SD +  + S S  +  +    D  +  +  E+            D+     
Sbjct: 886  NESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSN--------SSDNSNSSD 937

Query: 386  EYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKA 445
                  ++D        +        + S+  D  S D   S      S  ++ ++ S +
Sbjct: 938  SSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDS 997

Query: 446  AAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK 505
            +  +  S++   +      ++     +   +   D+ ++   S     +D  D     + 
Sbjct: 998  SDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNS 1057

Query: 506  VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE 565
                   +  +     + +   D    E  D          S       S D    + S 
Sbjct: 1058 SDSSDSSDSSDSSDSSDSSDSSD--SSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1115

Query: 566  DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDS 625
            D S   N+S          ++ S   S +  S+  + +     S    D  D+ D    S
Sbjct: 1116 DSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSS 1175

Query: 626  LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK 685
                  D  ++    D       ++  D     D +           +  D      +  
Sbjct: 1176 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD--------SSDSSDSSDSSDSSD 1227

Query: 686  SEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAK 745
            S DS + +D  D  D+      S  S +  S ++  D   ++ S SK+        DS  
Sbjct: 1228 SSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDS 1287

Query: 746  TTE 748
             +E
Sbjct: 1288 DSE 1290



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 121/743 (16%), Positives = 236/743 (31%), Gaps = 60/743 (8%)

Query: 28   SEKTSESPSKPGEKKGSDEKKAASLGS-SQSSRTYAGGTASATKVSASSGATSKSSSMNP 86
            SE  + S S+      SDE K    GS S+ +      + S T  S S+G  +  +  N 
Sbjct: 479  SESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDN- 537

Query: 87   TETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVS 146
                        KS S K      K          +   S    +SD+ S+D+ N  + S
Sbjct: 538  -----------DKSDSGK-----GKSDSSDSDSSDSSNSSDSSDSSDSDSSDS-NSSSDS 580

Query: 147  RSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKE-KKSLTPAVPVESKP 205
             S++   S+ S    +   +   +   S +  ++ S    D K +  KS + +   +SK 
Sbjct: 581  DSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKS 640

Query: 206  DKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPK 265
            D     S   +   D  D+      ++  +++ +    S   SS   +     + +   +
Sbjct: 641  DSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSE 700

Query: 266  YRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEK 325
                        D+ D+  SD +  S ++    ++ + S     + S+ +  S+      
Sbjct: 701  ----------SSDSSDSSDSDSSDSSDSSNSNSSDSDSSN---SSDSSDSSNSSDSSDSS 747

Query: 326  KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPS 385
                  D+         S S  +  +    D  +  + +++    +  +     D +  S
Sbjct: 748  DSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSS 807

Query: 386  EYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKA 445
            +     +   D               S+S      S+  D S+  +     +    +S  
Sbjct: 808  D----SSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSN 863

Query: 446  AAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK 505
            ++ +  S     +S  S  S   E +    +         +DS    ++D  D     D 
Sbjct: 864  SSDSSDSSDSSNSSDSSDSSDSNESSNSSDS---------SDSSNSSDSDSSDSSNSSDS 914

Query: 506  VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE 565
                   +  E     + +   D                 +S       +     D+ S 
Sbjct: 915  SDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSS 974

Query: 566  DFSGPQNAS----------SLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDL 615
            D S   N+S          S    D+  ++  S+    + +S +   +   D+S S  D 
Sbjct: 975  DSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNS-SDS 1033

Query: 616  DDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLD-DNG 674
             D+ D    S      D  ++    D       ++  D     D +   E     D  N 
Sbjct: 1034 SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNS 1093

Query: 675  QDKPVKPPTKKSEDSKKPADDQDPIDA--LSGDLDSCPSTTETSQNTAKDKCKKAASSSK 732
             D      +  S DS   +D  D  D+   S   DS  S+  +  + + D    + SS  
Sbjct: 1094 SDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDS 1153

Query: 733  APKNGGKAKDSAKTTEETSKPKD 755
            +  +       +  + ++S   D
Sbjct: 1154 SDSSDSSDSSDSSDSSDSSDSSD 1176


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 151/747 (20%), Positives = 243/747 (32%), Gaps = 73/747 (9%)

Query: 31  TSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETK 90
           TS+  S    K+ + E K  +  + Q+S      T SA +  +    ++K   + PT   
Sbjct: 136 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD--LAPTSKV 193

Query: 91  AVKTEPEKKSQSTKLSVVHEKKSQEGKPKE--HTEPKS-LPKQASDTGSNDAHNKKAVSR 147
             K  P+ ++ +   ++   K+     PKE   T PK   P       +         ++
Sbjct: 194 LAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTK 253

Query: 148 SAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDK 207
           SA   P E +  P T  +   +   E     T    +P     +    TP  P  + P K
Sbjct: 254 SAPTTPKEPA--PTTTKEPAPTTPKEPAPTTTK---EPAPTTTKSAPTTPKEPAPTTPKK 308

Query: 208 PSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYR 267
           P+  +  + A          P+E          P   +P  +T  E       T P K  
Sbjct: 309 PAPTTPKEPAPTT-------PKEPTPTTPKEPAPTTKEPAPTTPKEPAP----TAPKKPA 357

Query: 268 ELLAK---PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQE 324
               K   P  P +     + + +  +P      T K   T   +     T  +   P+E
Sbjct: 358 PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 417

Query: 325 KKRKVEKD----TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDD 380
                 K+    T  + A         T   EP     + KE      K+       E  
Sbjct: 418 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKPAPTTPKEPA 475

Query: 381 ETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDRSECKEKPSK 435
            T P E    P T K   P  PE       EKP P +  EL     E+         P+ 
Sbjct: 476 PTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE-------PTPTT 526

Query: 436 PTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEALADSLGKK 492
           P E    + KAAAP    E    T      + P EPA  T K T P    +  A +  K+
Sbjct: 527 PEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KGTAPTTLKE 585

Query: 493 EADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES----- 547
            A     KP   ++     +E      +K     P         K   P  PKE      
Sbjct: 586 PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTPKEPAPTTP 636

Query: 548 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 607
           KE  P   +      L E    P   +  K    +LA   ++  + T +       P   
Sbjct: 637 KEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKET 692

Query: 608 TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR 667
              + K+      K         P P  ++       ++    H+      D++ P    
Sbjct: 693 APTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----DESTPELSA 748

Query: 668 HLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETSQNTAKDKC 724
                  ++ P +P  PT K+  + KP       D  +  DL + P TT  +    K+  
Sbjct: 749 EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETA 808

Query: 725 KKAASSSKAPKNGGKAKDSAKTTEETS 751
                ++++       + ++ TT++T+
Sbjct: 809 TTTEKTTESKITATTTQVTSTTTQDTT 835



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 126/612 (20%), Positives = 203/612 (33%), Gaps = 70/612 (11%)

Query: 11  SPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATK 70
           +P   +  A   T E     T  +P+ P E   +  KK A     + + T        T 
Sbjct: 271 APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTP---KEPTP 327

Query: 71  VSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK-SLPK 129
            +    A +       T  +   T P+K + +T          +E  P    EP  + PK
Sbjct: 328 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPK 386

Query: 130 QASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKK 189
           + + T +     K A + + E  P+   + P T P++      +  A  T     P   K
Sbjct: 387 EPAPTTT-----KSAPTTTKEPAPTTTKSAPTT-PKEPSPTTTKEPAPTTPKEPAPTTPK 440

Query: 190 KEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSS 249
           K   + TP  P  + P +P+  +    A          P+E        T P     ++ 
Sbjct: 441 KPAPT-TPKEPAPTTPKEPAPTTTKKPAPTT-------PKEPAPTTPKETAPTTPKKLTP 492

Query: 250 TYIEELGKREVTIP-PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVL 308
           T  E+L       P P   E LA P  P++       +    +P AA   T KE +    
Sbjct: 493 TTPEKLAPTTPEKPAPTTPEELA-PTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTP 551

Query: 309 KAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKA 368
           K  +  T +  AP   K  +    T    A   L     T   +P     + KE+     
Sbjct: 552 KEPAPTTPKEPAPTTPK--ETAPTTPKGTAPTTLKEPAPTTPKKP-----APKELAPTTT 604

Query: 369 KEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSE 428
           KE     C +   T P      P T K+  P  P+      P+  +              
Sbjct: 605 KEPTSTTCDKPAPTTPK--GTAPTTPKEPAPTTPKEPAPTTPKGTA------------PT 650

Query: 429 CKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADS 488
             ++P+  T K    K  AP         T      S  P P T K T P    E  A +
Sbjct: 651 TLKEPAPTTPKKPAPKELAPTTTKGPTSTT------SDKPAPTTPKETAPTTPKEP-APT 703

Query: 489 LGKKEA--DPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDY-------RLEEVKDKDG 539
             KK A   PE   P   +V      ++   + +  +   P+         LE    + G
Sbjct: 704 TPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPG 763

Query: 540 KPL--LPKESKEQLPPMSEDFLLD----------ALSEDFSGPQNASSLKFEDAKLAAAI 587
            P    P  +K ++   ++D   +            +   +     ++ K  ++K+ A  
Sbjct: 764 VPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATT 823

Query: 588 SEVVSQTPASTT 599
           ++V S T   TT
Sbjct: 824 TQVTSTTTQDTT 835



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 101/497 (20%), Positives = 164/497 (32%), Gaps = 36/497 (7%)

Query: 272 KPIGPDDAIDALSS-DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE 330
           KP   D+A   L + DF   +P  +  +  K  ++  +        R + PP     K  
Sbjct: 81  KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 140

Query: 331 KDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 389
             T++ +  +E    +   +Q   +      KE   +  + + +EK    D    S+   
Sbjct: 141 SLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLA 195

Query: 390 KPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 446
           KP    +     P L  P+E P P +  E      ++   +  K  P+ P E    +  +
Sbjct: 196 KPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKS 254

Query: 447 APAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKV 506
           AP    E    T+     + P EPA      P       A +  K+ A     KP     
Sbjct: 255 APTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 314

Query: 507 KEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLPPMSEDFLL 560
           KE A    +E      +E  P          K+  P  PK+      KE  P   ++   
Sbjct: 315 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAP 374

Query: 561 DALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS-QSDKDLDD 617
               E       + +   E A      +   ++ PA TT   AP  P++ S  + K+   
Sbjct: 375 TTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 428

Query: 618 ALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 676
              K       ++P P   K P     KE A    +    +   T P E           
Sbjct: 429 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAPTTPKETAP 484

Query: 677 KPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKN 736
              K  T  + +   P   + P      +L   P+T E    T  ++       + AP  
Sbjct: 485 TTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTTPKAAAPNT 542

Query: 737 GGKAKDSAKTTEETSKP 753
               K+ A TT +   P
Sbjct: 543 ---PKEPAPTTPKEPAP 556



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 127/614 (20%), Positives = 206/614 (33%), Gaps = 92/614 (14%)

Query: 7    KPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTA 66
            K  A   P+  A         +     +P+ P E   +  KK A     + + T    TA
Sbjct: 424  KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETA 483

Query: 67   SATKVSASSGATSKSSSMNP------TETKAVKTEPEKKSQST--KLSVVHEKKSQEGKP 118
              T    +     K +   P      T  +   T PE+ + +T  + +    K +    P
Sbjct: 484  PTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP 543

Query: 119  KEH--TEPK----SLPKQASDTGSNDAH--NKKAVSRSAEQQPSEKSTEPKTKPQDMISA 170
            KE   T PK    + PK+ + T   +      K  + +  ++P+  +T  K  P+++   
Sbjct: 544  KEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP-TTPKKPAPKELAPT 602

Query: 171  GGESVAGITAISGKP----GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 226
              +     T     P    G      K   P  P E  P  P G +      +    T  
Sbjct: 603  TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPK 661

Query: 227  GPEETEEENTTYTGPE--VSDPMSSTYIEELG----KREVTIPPKYRELLAKPIGPDDAI 280
             P   E   TT  GP    SD  + T  +E      K      PK +     P  P    
Sbjct: 662  KPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPK-KPAPTTPETPPPTT 720

Query: 281  DALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP-----PQEKKRKVEKDTMS 335
              +S+  T   PT   K  +  EST  L A+        +P     P  K     K  M+
Sbjct: 721  SEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMT 778

Query: 336  DQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEY-----RLK 390
              A +  +          E DLR+  E   A  K  K E     ++T  S+      ++ 
Sbjct: 779  TTAKDKTT----------ERDLRTTPETTTAAPKMTK-ETATTTEKTTESKITATTTQVT 827

Query: 391  PATDKDGKP----------LLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKT 440
              T +D  P          L P+     K  + +E++++           E+ +KP ++ 
Sbjct: 828  STTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK----------PEETAKPKDRA 877

Query: 441  EESKAAAPAPVSEAVCRTSMCSIQ-----------SAPPEPATLKGTVPD-DAVEALADS 488
              SKA  P P           S +              P P  +  T+P+ +    +A++
Sbjct: 878  TNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEA 937

Query: 489  LGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET-----IPPDYRLEEVKDKDGKPLL 543
            + +    P    P    V+   K ED    G + ET      P  +  E   D D  P +
Sbjct: 938  MLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHMLLRPHVFMPEVTPDMDYLPRV 994

Query: 544  PKESKEQLPPMSED 557
            P +     P +S++
Sbjct: 995  PNQGIIINPMLSDE 1008



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 72/343 (20%), Positives = 114/343 (33%), Gaps = 45/343 (13%)

Query: 189 KKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPE-ETEEENTTYTGPEVSDPM 247
           K  KK+ T   P    P      SG+D   D  + T   P+  T + N   T P+++   
Sbjct: 67  KDNKKNRTKKKPTPKPPVVDEAGSGLDNG-DFKVTT---PDTSTTQHNKVSTSPKITT-- 120

Query: 248 SSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 307
                                  AKPI P  ++   S      S T   + T + + T  
Sbjct: 121 -----------------------AKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTT 157

Query: 308 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 367
              Q++   +      ++ + +EK +  D A  +   +  T +AE      ++    E  
Sbjct: 158 TNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPT 217

Query: 368 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPL------------LPEPEEKPKPRSESE 415
               K        E  P+  +  P T K+  P              P   ++P P +  E
Sbjct: 218 PTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKE 277

Query: 416 LIDELSEDFDRSECKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA-TL 473
                +++   +  K  P+ P E    + K  AP    E    T      + P EPA T 
Sbjct: 278 PAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTT 337

Query: 474 KGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDRE 516
           K   P    E  A +  KK A     +P     KE A    +E
Sbjct: 338 KEPAPTTPKEP-APTAPKKPAPTTPKEPAPTTPKEPAPTTTKE 379



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 54/255 (21%), Positives = 93/255 (36%), Gaps = 21/255 (8%)

Query: 508 EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDF 567
           E+ +E D +   +K +   PDY     + KD K    K+     PP+        + E  
Sbjct: 38  ERGRECDCDAQCKKYDKCCPDYESFCAEVKDNKKNRTKKKPTPKPPV--------VDEAG 89

Query: 568 SGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT--SQSDKDLDDALDKLSDS 625
           SG  N    K      +      VS +P  TT     PR +    SD   + +L    ++
Sbjct: 90  SGLDN-GDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKET 148

Query: 626 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDT--IPPEYRHLLDDNGQ-DKPVKPP 682
             + +     NK      KEK  +    +  E+     + P  + L     + +   K P
Sbjct: 149 TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP 208

Query: 683 TKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKC----KKAASSSKAPKNGG 738
              +     P   ++P  A +   +  P+T +++  T K+      K A ++ K P    
Sbjct: 209 ALTTPKEPTPTTPKEP--ASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA-PT 265

Query: 739 KAKDSAKTTEETSKP 753
             K+ A TT +   P
Sbjct: 266 TTKEPAPTTPKEPAP 280



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 62/329 (18%), Positives = 109/329 (33%), Gaps = 33/329 (10%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           + +P       P P+  A         +     +P+ P     +  K+ A     + + T
Sbjct: 583 LKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 642

Query: 61  YAGGTASATKVSASSGATSK--------SSSMNPTETKAVKTEPEKKSQSTKLSVVHEKK 112
              GTA  T    +     K        +++  PT T + K  P    ++   +      
Sbjct: 643 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 702

Query: 113 SQEGKPKEHTEPKSLPKQASDTGS-NDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAG 171
           +   KP   T P++ P   S+  +         + +S ++   E S EP  K  +     
Sbjct: 703 TTPKKPAP-TTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKE 761

Query: 172 GESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEET 231
                  T  + KP +     K  T    + + P+  +    M        +T    E+T
Sbjct: 762 PGVPTTKTPAATKP-EMTTTAKDKTTERDLRTTPETTTAAPKMTK------ETATTTEKT 814

Query: 232 EEENTTYTGPEVSD--PMSSTYIEELGKREVTIPPKY---------RELLAKP---IGPD 277
            E   T T  +V+      +T  +    +  T+ PK           E++ KP     P 
Sbjct: 815 TESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPK 874

Query: 278 DAIDALSSDFTCGSPTAAGKKTEKEESTE 306
           D   A +S  T   P    K  +K  ST+
Sbjct: 875 DR--ATNSKATTPKPQKPTKAPKKPTSTK 901


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 151/747 (20%), Positives = 243/747 (32%), Gaps = 73/747 (9%)

Query: 31  TSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETK 90
           TS+  S    K+ + E K  +  + Q+S      T SA +  +    ++K   + PT   
Sbjct: 177 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD--LAPTSKV 234

Query: 91  AVKTEPEKKSQSTKLSVVHEKKSQEGKPKE--HTEPKS-LPKQASDTGSNDAHNKKAVSR 147
             K  P+ ++ +   ++   K+     PKE   T PK   P       +         ++
Sbjct: 235 LAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTK 294

Query: 148 SAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDK 207
           SA   P E +  P T  +   +   E     T    +P     +    TP  P  + P K
Sbjct: 295 SAPTTPKEPA--PTTTKEPAPTTPKEPAPTTTK---EPAPTTTKSAPTTPKEPAPTTPKK 349

Query: 208 PSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYR 267
           P+  +  + A          P+E          P   +P  +T  E       T P K  
Sbjct: 350 PAPTTPKEPAPTT-------PKEPTPTTPKEPAPTTKEPAPTTPKEPAP----TAPKKPA 398

Query: 268 ELLAK---PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQE 324
               K   P  P +     + + +  +P      T K   T   +     T  +   P+E
Sbjct: 399 PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 458

Query: 325 KKRKVEKD----TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDD 380
                 K+    T  + A         T   EP     + KE      K+       E  
Sbjct: 459 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKPAPTTPKEPA 516

Query: 381 ETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDRSECKEKPSK 435
            T P E    P T K   P  PE       EKP P +  EL     E+         P+ 
Sbjct: 517 PTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE-------PTPTT 567

Query: 436 PTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEALADSLGKK 492
           P E    + KAAAP    E    T      + P EPA  T K T P    +  A +  K+
Sbjct: 568 PEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KGTAPTTLKE 626

Query: 493 EADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES----- 547
            A     KP   ++     +E      +K     P         K   P  PKE      
Sbjct: 627 PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTPKEPAPTTP 677

Query: 548 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 607
           KE  P   +      L E    P   +  K    +LA   ++  + T +       P   
Sbjct: 678 KEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKET 733

Query: 608 TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR 667
              + K+      K         P P  ++       ++    H+      D++ P    
Sbjct: 734 APTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----DESTPELSA 789

Query: 668 HLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETSQNTAKDKC 724
                  ++ P +P  PT K+  + KP       D  +  DL + P TT  +    K+  
Sbjct: 790 EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETA 849

Query: 725 KKAASSSKAPKNGGKAKDSAKTTEETS 751
                ++++       + ++ TT++T+
Sbjct: 850 TTTEKTTESKITATTTQVTSTTTQDTT 876



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 126/612 (20%), Positives = 203/612 (33%), Gaps = 70/612 (11%)

Query: 11  SPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATK 70
           +P   +  A   T E     T  +P+ P E   +  KK A     + + T        T 
Sbjct: 312 APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTP---KEPTP 368

Query: 71  VSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK-SLPK 129
            +    A +       T  +   T P+K + +T          +E  P    EP  + PK
Sbjct: 369 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPK 427

Query: 130 QASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKK 189
           + + T +     K A + + E  P+   + P T P++      +  A  T     P   K
Sbjct: 428 EPAPTTT-----KSAPTTTKEPAPTTTKSAPTT-PKEPSPTTTKEPAPTTPKEPAPTTPK 481

Query: 190 KEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSS 249
           K   + TP  P  + P +P+  +    A          P+E        T P     ++ 
Sbjct: 482 KPAPT-TPKEPAPTTPKEPAPTTTKKPAPTT-------PKEPAPTTPKETAPTTPKKLTP 533

Query: 250 TYIEELGKREVTIP-PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVL 308
           T  E+L       P P   E LA P  P++       +    +P AA   T KE +    
Sbjct: 534 TTPEKLAPTTPEKPAPTTPEELA-PTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTP 592

Query: 309 KAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKA 368
           K  +  T +  AP   K  +    T    A   L     T   +P     + KE+     
Sbjct: 593 KEPAPTTPKEPAPTTPK--ETAPTTPKGTAPTTLKEPAPTTPKKP-----APKELAPTTT 645

Query: 369 KEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSE 428
           KE     C +   T P      P T K+  P  P+      P+  +              
Sbjct: 646 KEPTSTTCDKPAPTTPK--GTAPTTPKEPAPTTPKEPAPTTPKGTA------------PT 691

Query: 429 CKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADS 488
             ++P+  T K    K  AP         T      S  P P T K T P    E  A +
Sbjct: 692 TLKEPAPTTPKKPAPKELAPTTTKGPTSTT------SDKPAPTTPKETAPTTPKEP-APT 744

Query: 489 LGKKEA--DPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDY-------RLEEVKDKDG 539
             KK A   PE   P   +V      ++   + +  +   P+         LE    + G
Sbjct: 745 TPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPG 804

Query: 540 KPL--LPKESKEQLPPMSEDFLLD----------ALSEDFSGPQNASSLKFEDAKLAAAI 587
            P    P  +K ++   ++D   +            +   +     ++ K  ++K+ A  
Sbjct: 805 VPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATT 864

Query: 588 SEVVSQTPASTT 599
           ++V S T   TT
Sbjct: 865 TQVTSTTTQDTT 876



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 101/497 (20%), Positives = 164/497 (32%), Gaps = 36/497 (7%)

Query: 272 KPIGPDDAIDALSS-DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE 330
           KP   D+A   L + DF   +P  +  +  K  ++  +        R + PP     K  
Sbjct: 122 KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 181

Query: 331 KDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 389
             T++ +  +E    +   +Q   +      KE   +  + + +EK    D    S+   
Sbjct: 182 SLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLA 236

Query: 390 KPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 446
           KP    +     P L  P+E P P +  E      ++   +  K  P+ P E    +  +
Sbjct: 237 KPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKS 295

Query: 447 APAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKV 506
           AP    E    T+     + P EPA      P       A +  K+ A     KP     
Sbjct: 296 APTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 355

Query: 507 KEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLPPMSEDFLL 560
           KE A    +E      +E  P          K+  P  PK+      KE  P   ++   
Sbjct: 356 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAP 415

Query: 561 DALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS-QSDKDLDD 617
               E       + +   E A      +   ++ PA TT   AP  P++ S  + K+   
Sbjct: 416 TTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 469

Query: 618 ALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 676
              K       ++P P   K P     KE A    +    +   T P E           
Sbjct: 470 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAPTTPKETAP 525

Query: 677 KPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKN 736
              K  T  + +   P   + P      +L   P+T E    T  ++       + AP  
Sbjct: 526 TTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTTPKAAAPNT 583

Query: 737 GGKAKDSAKTTEETSKP 753
               K+ A TT +   P
Sbjct: 584 ---PKEPAPTTPKEPAP 597



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 127/614 (20%), Positives = 206/614 (33%), Gaps = 92/614 (14%)

Query: 7    KPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTA 66
            K  A   P+  A         +     +P+ P E   +  KK A     + + T    TA
Sbjct: 465  KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETA 524

Query: 67   SATKVSASSGATSKSSSMNP------TETKAVKTEPEKKSQST--KLSVVHEKKSQEGKP 118
              T    +     K +   P      T  +   T PE+ + +T  + +    K +    P
Sbjct: 525  PTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP 584

Query: 119  KEH--TEPK----SLPKQASDTGSNDAH--NKKAVSRSAEQQPSEKSTEPKTKPQDMISA 170
            KE   T PK    + PK+ + T   +      K  + +  ++P+  +T  K  P+++   
Sbjct: 585  KEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP-TTPKKPAPKELAPT 643

Query: 171  GGESVAGITAISGKP----GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 226
              +     T     P    G      K   P  P E  P  P G +      +    T  
Sbjct: 644  TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPK 702

Query: 227  GPEETEEENTTYTGPE--VSDPMSSTYIEELG----KREVTIPPKYRELLAKPIGPDDAI 280
             P   E   TT  GP    SD  + T  +E      K      PK +     P  P    
Sbjct: 703  KPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPK-KPAPTTPETPPPTT 761

Query: 281  DALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP-----PQEKKRKVEKDTMS 335
              +S+  T   PT   K  +  EST  L A+        +P     P  K     K  M+
Sbjct: 762  SEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMT 819

Query: 336  DQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEY-----RLK 390
              A +  +          E DLR+  E   A  K  K E     ++T  S+      ++ 
Sbjct: 820  TTAKDKTT----------ERDLRTTPETTTAAPKMTK-ETATTTEKTTESKITATTTQVT 868

Query: 391  PATDKDGKP----------LLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKT 440
              T +D  P          L P+     K  + +E++++           E+ +KP ++ 
Sbjct: 869  STTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK----------PEETAKPKDRA 918

Query: 441  EESKAAAPAPVSEAVCRTSMCSIQ-----------SAPPEPATLKGTVPD-DAVEALADS 488
              SKA  P P           S +              P P  +  T+P+ +    +A++
Sbjct: 919  TNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEA 978

Query: 489  LGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET-----IPPDYRLEEVKDKDGKPLL 543
            + +    P    P    V+   K ED    G + ET      P  +  E   D D  P +
Sbjct: 979  MLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHMLLRPHVFMPEVTPDMDYLPRV 1035

Query: 544  PKESKEQLPPMSED 557
            P +     P +S++
Sbjct: 1036 PNQGIIINPMLSDE 1049



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 72/343 (20%), Positives = 114/343 (33%), Gaps = 45/343 (13%)

Query: 189 KKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPE-ETEEENTTYTGPEVSDPM 247
           K  KK+ T   P    P      SG+D   D  + T   P+  T + N   T P+++   
Sbjct: 108 KDNKKNRTKKKPTPKPPVVDEAGSGLDNG-DFKVTT---PDTSTTQHNKVSTSPKITT-- 161

Query: 248 SSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 307
                                  AKPI P  ++   S      S T   + T + + T  
Sbjct: 162 -----------------------AKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTT 198

Query: 308 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 367
              Q++   +      ++ + +EK +  D A  +   +  T +AE      ++    E  
Sbjct: 199 TNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPT 258

Query: 368 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPL------------LPEPEEKPKPRSESE 415
               K        E  P+  +  P T K+  P              P   ++P P +  E
Sbjct: 259 PTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKE 318

Query: 416 LIDELSEDFDRSECKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA-TL 473
                +++   +  K  P+ P E    + K  AP    E    T      + P EPA T 
Sbjct: 319 PAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTT 378

Query: 474 KGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDRE 516
           K   P    E  A +  KK A     +P     KE A    +E
Sbjct: 379 KEPAPTTPKEP-APTAPKKPAPTTPKEPAPTTPKEPAPTTTKE 420



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 54/255 (21%), Positives = 93/255 (36%), Gaps = 21/255 (8%)

Query: 508 EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDF 567
           E+ +E D +   +K +   PDY     + KD K    K+     PP+        + E  
Sbjct: 79  ERGRECDCDAQCKKYDKCCPDYESFCAEVKDNKKNRTKKKPTPKPPV--------VDEAG 130

Query: 568 SGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT--SQSDKDLDDALDKLSDS 625
           SG  N    K      +      VS +P  TT     PR +    SD   + +L    ++
Sbjct: 131 SGLDN-GDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKET 189

Query: 626 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDT--IPPEYRHLLDDNGQ-DKPVKPP 682
             + +     NK      KEK  +    +  E+     + P  + L     + +   K P
Sbjct: 190 TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP 249

Query: 683 TKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKC----KKAASSSKAPKNGG 738
              +     P   ++P  A +   +  P+T +++  T K+      K A ++ K P    
Sbjct: 250 ALTTPKEPTPTTPKEP--ASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA-PT 306

Query: 739 KAKDSAKTTEETSKP 753
             K+ A TT +   P
Sbjct: 307 TTKEPAPTTPKEPAP 321



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 62/329 (18%), Positives = 109/329 (33%), Gaps = 33/329 (10%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           + +P       P P+  A         +     +P+ P     +  K+ A     + + T
Sbjct: 624 LKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 683

Query: 61  YAGGTASATKVSASSGATSK--------SSSMNPTETKAVKTEPEKKSQSTKLSVVHEKK 112
              GTA  T    +     K        +++  PT T + K  P    ++   +      
Sbjct: 684 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 743

Query: 113 SQEGKPKEHTEPKSLPKQASDTGS-NDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAG 171
           +   KP   T P++ P   S+  +         + +S ++   E S EP  K  +     
Sbjct: 744 TTPKKPAP-TTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKE 802

Query: 172 GESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEET 231
                  T  + KP +     K  T    + + P+  +    M        +T    E+T
Sbjct: 803 PGVPTTKTPAATKP-EMTTTAKDKTTERDLRTTPETTTAAPKMTK------ETATTTEKT 855

Query: 232 EEENTTYTGPEVSD--PMSSTYIEELGKREVTIPPKY---------RELLAKP---IGPD 277
            E   T T  +V+      +T  +    +  T+ PK           E++ KP     P 
Sbjct: 856 TESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPK 915

Query: 278 DAIDALSSDFTCGSPTAAGKKTEKEESTE 306
           D   A +S  T   P    K  +K  ST+
Sbjct: 916 DR--ATNSKATTPKPQKPTKAPKKPTSTK 942


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 147/758 (19%), Positives = 243/758 (32%), Gaps = 76/758 (10%)

Query: 8   PAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTAS 67
           P + P  ++A       + +   T  SP  P +KK     ++  +    S          
Sbjct: 69  PTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHS---------V 119

Query: 68  ATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSL 127
           +    +SS ++S SSS    + K+ K     +    KL V   KK+   + K+   PK  
Sbjct: 120 SENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKN---RTKKKPTPKPP 176

Query: 128 PKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGD 187
               + +G ++   K     ++  Q ++ ST PK                          
Sbjct: 177 VVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPK-------------------------- 210

Query: 188 KKKEKKSLTPAVPVESKPD-KPSGKSGMDAALDDLIDTLGGPEETEEEN--TTYTGPEVS 244
                  +T A P+  +P   P+  +  + +L    +T    +ET   N  T+  G E +
Sbjct: 211 -------ITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKT 263

Query: 245 DPMSSTY-IEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEE 303
                T  IE+   +++    K   +LAKP    +      +  T   PT     T KE 
Sbjct: 264 TSAKETQSIEKTSAKDLAPTSK---VLAKPTPKAETTTKGPALTTPKEPTPT---TPKEP 317

Query: 304 STEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEV 363
           ++   K  +  T++SA  P   K      T S        A   T++  P          
Sbjct: 318 ASTTPKEPTPTTIKSA--PTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT 375

Query: 364 DEAKAKEEKLEKCGEDDETIP-SEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSE 422
            +  A            E  P +  +  P T K+  P  P+      P+  +    E + 
Sbjct: 376 TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP 435

Query: 423 DFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPA-TLKGTVPDDA 481
              +      P KP   T   K  AP    E    T+     + P EPA T   + P   
Sbjct: 436 TTPKEPAPTAPKKPAPTT--PKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 493

Query: 482 VEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKP 541
            E    +       P++  P     KE A    +E      +   P    E       +P
Sbjct: 494 KEPAPTTTKSAPTTPKEPSPT--TTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 551

Query: 542 LLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSL-KFEDAKLAAAISEVVSQTPASTTQ 600
             P  +K+  P   ++       E  + P     L      KLA    E  + T      
Sbjct: 552 -APTTTKKPAPTTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELA 608

Query: 601 AGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERD 659
              P   T  + ++      K +     ++P P   K P     KE A    ++      
Sbjct: 609 PTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP 668

Query: 660 DTIPPEYRHLLDDNGQDKPVKPPTKK--SEDSKKPADDQDPIDALSGDLDSCPSTTETSQ 717
               P     L +     P KP  K+     +K+P        A +    + P+T +   
Sbjct: 669 KGTAPT---TLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 725

Query: 718 NTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKD 755
            T   +         AP      K+ A TT +   PK+
Sbjct: 726 PTTPKEPAPTTPKGTAPTT---LKEPAPTTPKKPAPKE 760



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 151/747 (20%), Positives = 243/747 (32%), Gaps = 73/747 (9%)

Query: 31  TSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETK 90
           TS+  S    K+ + E K  +  + Q+S      T SA +  +    ++K   + PT   
Sbjct: 229 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD--LAPTSKV 286

Query: 91  AVKTEPEKKSQSTKLSVVHEKKSQEGKPKE--HTEPKS-LPKQASDTGSNDAHNKKAVSR 147
             K  P+ ++ +   ++   K+     PKE   T PK   P       +         ++
Sbjct: 287 LAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTK 346

Query: 148 SAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDK 207
           SA   P E +  P T  +   +   E     T    +P     +    TP  P  + P K
Sbjct: 347 SAPTTPKEPA--PTTTKEPAPTTPKEPAPTTTK---EPAPTTTKSAPTTPKEPAPTTPKK 401

Query: 208 PSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYR 267
           P+  +  + A          P+E          P   +P  +T  E       T P K  
Sbjct: 402 PAPTTPKEPAPTT-------PKEPTPTTPKEPAPTTKEPAPTTPKEPAP----TAPKKPA 450

Query: 268 ELLAK---PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQE 324
               K   P  P +     + + +  +P      T K   T   +     T  +   P+E
Sbjct: 451 PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 510

Query: 325 KKRKVEKD----TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDD 380
                 K+    T  + A         T   EP     + KE      K+       E  
Sbjct: 511 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKPAPTTPKEPA 568

Query: 381 ETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDRSECKEKPSK 435
            T P E    P T K   P  PE       EKP P +  EL     E+         P+ 
Sbjct: 569 PTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE-------PTPTT 619

Query: 436 PTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEALADSLGKK 492
           P E    + KAAAP    E    T      + P EPA  T K T P    +  A +  K+
Sbjct: 620 PEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KGTAPTTLKE 678

Query: 493 EADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES----- 547
            A     KP   ++     +E      +K     P         K   P  PKE      
Sbjct: 679 PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTPKEPAPTTP 729

Query: 548 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 607
           KE  P   +      L E    P   +  K    +LA   ++  + T +       P   
Sbjct: 730 KEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKET 785

Query: 608 TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR 667
              + K+      K         P P  ++       ++    H+      D++ P    
Sbjct: 786 APTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----DESTPELSA 841

Query: 668 HLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETSQNTAKDKC 724
                  ++ P +P  PT K+  + KP       D  +  DL + P TT  +    K+  
Sbjct: 842 EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETA 901

Query: 725 KKAASSSKAPKNGGKAKDSAKTTEETS 751
                ++++       + ++ TT++T+
Sbjct: 902 TTTEKTTESKITATTTQVTSTTTQDTT 928



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 127/614 (20%), Positives = 206/614 (33%), Gaps = 92/614 (14%)

Query: 7    KPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTA 66
            K  A   P+  A         +     +P+ P E   +  KK A     + + T    TA
Sbjct: 517  KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETA 576

Query: 67   SATKVSASSGATSKSSSMNP------TETKAVKTEPEKKSQST--KLSVVHEKKSQEGKP 118
              T    +     K +   P      T  +   T PE+ + +T  + +    K +    P
Sbjct: 577  PTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP 636

Query: 119  KEH--TEPK----SLPKQASDTGSNDAH--NKKAVSRSAEQQPSEKSTEPKTKPQDMISA 170
            KE   T PK    + PK+ + T   +      K  + +  ++P+  +T  K  P+++   
Sbjct: 637  KEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP-TTPKKPAPKELAPT 695

Query: 171  GGESVAGITAISGKP----GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 226
              +     T     P    G      K   P  P E  P  P G +      +    T  
Sbjct: 696  TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPK 754

Query: 227  GPEETEEENTTYTGPE--VSDPMSSTYIEELG----KREVTIPPKYRELLAKPIGPDDAI 280
             P   E   TT  GP    SD  + T  +E      K      PK +     P  P    
Sbjct: 755  KPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPK-KPAPTTPETPPPTT 813

Query: 281  DALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP-----PQEKKRKVEKDTMS 335
              +S+  T   PT   K  +  EST  L A+        +P     P  K     K  M+
Sbjct: 814  SEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMT 871

Query: 336  DQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEY-----RLK 390
              A +  +          E DLR+  E   A  K  K E     ++T  S+      ++ 
Sbjct: 872  TTAKDKTT----------ERDLRTTPETTTAAPKMTK-ETATTTEKTTESKITATTTQVT 920

Query: 391  PATDKDGKP----------LLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKT 440
              T +D  P          L P+     K  + +E++++           E+ +KP ++ 
Sbjct: 921  STTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK----------PEETAKPKDRA 970

Query: 441  EESKAAAPAPVSEAVCRTSMCSIQ-----------SAPPEPATLKGTVPD-DAVEALADS 488
              SKA  P P           S +              P P  +  T+P+ +    +A++
Sbjct: 971  TNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEA 1030

Query: 489  LGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET-----IPPDYRLEEVKDKDGKPLL 543
            + +    P    P    V+   K ED    G + ET      P  +  E   D D  P +
Sbjct: 1031 MLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHMLLRPHVFMPEVTPDMDYLPRV 1087

Query: 544  PKESKEQLPPMSED 557
            P +     P +S++
Sbjct: 1088 PNQGIIINPMLSDE 1101



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 62/329 (18%), Positives = 109/329 (33%), Gaps = 33/329 (10%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           + +P       P P+  A         +     +P+ P     +  K+ A     + + T
Sbjct: 676 LKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 735

Query: 61  YAGGTASATKVSASSGATSK--------SSSMNPTETKAVKTEPEKKSQSTKLSVVHEKK 112
              GTA  T    +     K        +++  PT T + K  P    ++   +      
Sbjct: 736 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 795

Query: 113 SQEGKPKEHTEPKSLPKQASDTGS-NDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAG 171
           +   KP   T P++ P   S+  +         + +S ++   E S EP  K  +     
Sbjct: 796 TTPKKPAP-TTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKE 854

Query: 172 GESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEET 231
                  T  + KP +     K  T    + + P+  +    M        +T    E+T
Sbjct: 855 PGVPTTKTPAATKP-EMTTTAKDKTTERDLRTTPETTTAAPKMTK------ETATTTEKT 907

Query: 232 EEENTTYTGPEVSD--PMSSTYIEELGKREVTIPPKY---------RELLAKP---IGPD 277
            E   T T  +V+      +T  +    +  T+ PK           E++ KP     P 
Sbjct: 908 TESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPK 967

Query: 278 DAIDALSSDFTCGSPTAAGKKTEKEESTE 306
           D   A +S  T   P    K  +K  ST+
Sbjct: 968 DR--ATNSKATTPKPQKPTKAPKKPTSTK 994


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 147/758 (19%), Positives = 243/758 (32%), Gaps = 76/758 (10%)

Query: 8   PAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTAS 67
           P + P  ++A       + +   T  SP  P +KK     ++  +    S          
Sbjct: 110 PTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHS---------V 160

Query: 68  ATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSL 127
           +    +SS ++S SSS    + K+ K     +    KL V   KK+   + K+   PK  
Sbjct: 161 SENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKN---RTKKKPTPKPP 217

Query: 128 PKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGD 187
               + +G ++   K     ++  Q ++ ST PK                          
Sbjct: 218 VVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPK-------------------------- 251

Query: 188 KKKEKKSLTPAVPVESKPD-KPSGKSGMDAALDDLIDTLGGPEETEEEN--TTYTGPEVS 244
                  +T A P+  +P   P+  +  + +L    +T    +ET   N  T+  G E +
Sbjct: 252 -------ITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKT 304

Query: 245 DPMSSTY-IEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEE 303
                T  IE+   +++    K   +LAKP    +      +  T   PT     T KE 
Sbjct: 305 TSAKETQSIEKTSAKDLAPTSK---VLAKPTPKAETTTKGPALTTPKEPTPT---TPKEP 358

Query: 304 STEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEV 363
           ++   K  +  T++SA  P   K      T S        A   T++  P          
Sbjct: 359 ASTTPKEPTPTTIKSA--PTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT 416

Query: 364 DEAKAKEEKLEKCGEDDETIP-SEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSE 422
            +  A            E  P +  +  P T K+  P  P+      P+  +    E + 
Sbjct: 417 TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP 476

Query: 423 DFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPA-TLKGTVPDDA 481
              +      P KP   T   K  AP    E    T+     + P EPA T   + P   
Sbjct: 477 TTPKEPAPTAPKKPAPTT--PKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 534

Query: 482 VEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKP 541
            E    +       P++  P     KE A    +E      +   P    E       +P
Sbjct: 535 KEPAPTTTKSAPTTPKEPSPT--TTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 592

Query: 542 LLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSL-KFEDAKLAAAISEVVSQTPASTTQ 600
             P  +K+  P   ++       E  + P     L      KLA    E  + T      
Sbjct: 593 -APTTTKKPAPTTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELA 649

Query: 601 AGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERD 659
              P   T  + ++      K +     ++P P   K P     KE A    ++      
Sbjct: 650 PTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP 709

Query: 660 DTIPPEYRHLLDDNGQDKPVKPPTKK--SEDSKKPADDQDPIDALSGDLDSCPSTTETSQ 717
               P     L +     P KP  K+     +K+P        A +    + P+T +   
Sbjct: 710 KGTAPT---TLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 766

Query: 718 NTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKD 755
            T   +         AP      K+ A TT +   PK+
Sbjct: 767 PTTPKEPAPTTPKGTAPTT---LKEPAPTTPKKPAPKE 801



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 151/747 (20%), Positives = 243/747 (32%), Gaps = 73/747 (9%)

Query: 31  TSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETK 90
           TS+  S    K+ + E K  +  + Q+S      T SA +  +    ++K   + PT   
Sbjct: 270 TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD--LAPTSKV 327

Query: 91  AVKTEPEKKSQSTKLSVVHEKKSQEGKPKE--HTEPKS-LPKQASDTGSNDAHNKKAVSR 147
             K  P+ ++ +   ++   K+     PKE   T PK   P       +         ++
Sbjct: 328 LAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTK 387

Query: 148 SAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDK 207
           SA   P E +  P T  +   +   E     T    +P     +    TP  P  + P K
Sbjct: 388 SAPTTPKEPA--PTTTKEPAPTTPKEPAPTTTK---EPAPTTTKSAPTTPKEPAPTTPKK 442

Query: 208 PSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYR 267
           P+  +  + A          P+E          P   +P  +T  E       T P K  
Sbjct: 443 PAPTTPKEPAPTT-------PKEPTPTTPKEPAPTTKEPAPTTPKEPAP----TAPKKPA 491

Query: 268 ELLAK---PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQE 324
               K   P  P +     + + +  +P      T K   T   +     T  +   P+E
Sbjct: 492 PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 551

Query: 325 KKRKVEKD----TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDD 380
                 K+    T  + A         T   EP     + KE      K+       E  
Sbjct: 552 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKPAPTTPKEPA 609

Query: 381 ETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDRSECKEKPSK 435
            T P E    P T K   P  PE       EKP P +  EL     E+         P+ 
Sbjct: 610 PTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE-------PTPTT 660

Query: 436 PTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEALADSLGKK 492
           P E    + KAAAP    E    T      + P EPA  T K T P    +  A +  K+
Sbjct: 661 PEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KGTAPTTLKE 719

Query: 493 EADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES----- 547
            A     KP   ++     +E      +K     P         K   P  PKE      
Sbjct: 720 PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTPKEPAPTTP 770

Query: 548 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 607
           KE  P   +      L E    P   +  K    +LA   ++  + T +       P   
Sbjct: 771 KEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKET 826

Query: 608 TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR 667
              + K+      K         P P  ++       ++    H+      D++ P    
Sbjct: 827 APTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----DESTPELSA 882

Query: 668 HLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETSQNTAKDKC 724
                  ++ P +P  PT K+  + KP       D  +  DL + P TT  +    K+  
Sbjct: 883 EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETA 942

Query: 725 KKAASSSKAPKNGGKAKDSAKTTEETS 751
                ++++       + ++ TT++T+
Sbjct: 943 TTTEKTTESKITATTTQVTSTTTQDTT 969



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 127/614 (20%), Positives = 206/614 (33%), Gaps = 92/614 (14%)

Query: 7    KPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTA 66
            K  A   P+  A         +     +P+ P E   +  KK A     + + T    TA
Sbjct: 558  KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETA 617

Query: 67   SATKVSASSGATSKSSSMNP------TETKAVKTEPEKKSQST--KLSVVHEKKSQEGKP 118
              T    +     K +   P      T  +   T PE+ + +T  + +    K +    P
Sbjct: 618  PTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP 677

Query: 119  KEH--TEPK----SLPKQASDTGSNDAH--NKKAVSRSAEQQPSEKSTEPKTKPQDMISA 170
            KE   T PK    + PK+ + T   +      K  + +  ++P+  +T  K  P+++   
Sbjct: 678  KEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP-TTPKKPAPKELAPT 736

Query: 171  GGESVAGITAISGKP----GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 226
              +     T     P    G      K   P  P E  P  P G +      +    T  
Sbjct: 737  TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPK 795

Query: 227  GPEETEEENTTYTGPE--VSDPMSSTYIEELG----KREVTIPPKYRELLAKPIGPDDAI 280
             P   E   TT  GP    SD  + T  +E      K      PK +     P  P    
Sbjct: 796  KPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPK-KPAPTTPETPPPTT 854

Query: 281  DALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP-----PQEKKRKVEKDTMS 335
              +S+  T   PT   K  +  EST  L A+        +P     P  K     K  M+
Sbjct: 855  SEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMT 912

Query: 336  DQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEY-----RLK 390
              A +  +          E DLR+  E   A  K  K E     ++T  S+      ++ 
Sbjct: 913  TTAKDKTT----------ERDLRTTPETTTAAPKMTK-ETATTTEKTTESKITATTTQVT 961

Query: 391  PATDKDGKP----------LLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKT 440
              T +D  P          L P+     K  + +E++++           E+ +KP ++ 
Sbjct: 962  STTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK----------PEETAKPKDRA 1011

Query: 441  EESKAAAPAPVSEAVCRTSMCSIQ-----------SAPPEPATLKGTVPD-DAVEALADS 488
              SKA  P P           S +              P P  +  T+P+ +    +A++
Sbjct: 1012 TNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEA 1071

Query: 489  LGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET-----IPPDYRLEEVKDKDGKPLL 543
            + +    P    P    V+   K ED    G + ET      P  +  E   D D  P +
Sbjct: 1072 MLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHMLLRPHVFMPEVTPDMDYLPRV 1128

Query: 544  PKESKEQLPPMSED 557
            P +     P +S++
Sbjct: 1129 PNQGIIINPMLSDE 1142



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 62/329 (18%), Positives = 109/329 (33%), Gaps = 33/329 (10%)

Query: 1    MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
            + +P       P P+  A         +     +P+ P     +  K+ A     + + T
Sbjct: 717  LKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 776

Query: 61   YAGGTASATKVSASSGATSK--------SSSMNPTETKAVKTEPEKKSQSTKLSVVHEKK 112
               GTA  T    +     K        +++  PT T + K  P    ++   +      
Sbjct: 777  TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 836

Query: 113  SQEGKPKEHTEPKSLPKQASDTGS-NDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAG 171
            +   KP   T P++ P   S+  +         + +S ++   E S EP  K  +     
Sbjct: 837  TTPKKPAP-TTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKE 895

Query: 172  GESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEET 231
                   T  + KP +     K  T    + + P+  +    M        +T    E+T
Sbjct: 896  PGVPTTKTPAATKP-EMTTTAKDKTTERDLRTTPETTTAAPKMTK------ETATTTEKT 948

Query: 232  EEENTTYTGPEVSD--PMSSTYIEELGKREVTIPPKY---------RELLAKP---IGPD 277
             E   T T  +V+      +T  +    +  T+ PK           E++ KP     P 
Sbjct: 949  TESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPK 1008

Query: 278  DAIDALSSDFTCGSPTAAGKKTEKEESTE 306
            D   A +S  T   P    K  +K  ST+
Sbjct: 1009 DR--ATNSKATTPKPQKPTKAPKKPTSTK 1035


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 135/652 (20%), Positives = 232/652 (35%), Gaps = 107/652 (16%)

Query: 30  KTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTET 89
           K  E     G+KK   EKK          +     +  A  + A     +   + N  E 
Sbjct: 33  KEQEPQKSKGKKK--KEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTEN-NEE 89

Query: 90  KAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSL-PKQASDTGSNDAHN-----KK 143
           +    + +KK Q  K     +  S+E + K+    K+  PK    +GS+D  +     KK
Sbjct: 90  EFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKK 149

Query: 144 AVSRSAEQQPS------EKSTEPKTKPQDMISAGGESV-AGITAISGKPGDKKKEKKSLT 196
           A  ++ +          ++    K K +  I++ GES       +  + G KK +K    
Sbjct: 150 AKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPG 209

Query: 197 PAVPVESKPDKPSGKSGMDAAL------------DDLIDTLGGPEETEEENTTYTGPEVS 244
           P +   ++ D  S K    A              D+    L   +E EE  T        
Sbjct: 210 PNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQ 269

Query: 245 DPMSSTYIEELGKREVTIP----PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTE 300
                 + EE  K +VT+     P   E    P   +D  +        G      KK +
Sbjct: 270 KESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNE--------GDKKKKDKKKK 321

Query: 301 KEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMS--DQALEALSASLGTRQAEPELDLR 358
           K E  E  K              EKK+   K T+    +AL  L      ++ E E  ++
Sbjct: 322 KGEKEEKEK--------------EKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIK 367

Query: 359 SIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELID 418
            ++E++  + +EE+LE+  + +     E   K    K+GK LL + + + + R+E+ L  
Sbjct: 368 RLEELEAKRKEEERLEQ-EKRERKKQKEKERKERLKKEGK-LLTKSQREARARAEATLKL 425

Query: 419 ELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSM--CSIQSAPPEPATLKGT 476
             ++  +       P K     ++ +   P  +       SM  C+              
Sbjct: 426 LQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCA-------------- 471

Query: 477 VPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKD 536
               AVE +   + +KE  P   +P  ++  E A  +D E +   EET   +     ++ 
Sbjct: 472 ----AVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEV 527

Query: 537 KDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPA 596
           K+     P+E +E+     ED   +   E+  G    S    ED K++            
Sbjct: 528 KEN----PEEEEEEEEEEEEDEESEE-EEEEEGESEGSEGDEEDEKVS------------ 570

Query: 597 STTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 648
                     D   S K LD    K   S    + D D+++  E++  +KAK
Sbjct: 571 ----------DEKDSGKTLDKKPSKEMSS--DSEYDSDDDRTKEERAYDKAK 610



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 120/643 (18%), Positives = 232/643 (36%), Gaps = 107/643 (16%)

Query: 110 EKKSQEGKPKEHTEPKSLPKQASDTGS--NDAHNKKAVSRSAEQQPSEKSTEPKTKPQDM 167
           +K   E   K+  +  +L  +    G+       K    +  E++  +   +   K  + 
Sbjct: 5   QKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE 64

Query: 168 ISAGGESV-AGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 226
           +S   + + A    ++ KP +  +E+ +        SK  K  G+ G   + DD      
Sbjct: 65  LSLEAQGIKADRETVAVKPTENNEEEFT--------SKDKKKKGQKGKKQSFDD-----N 111

Query: 227 GPEETEEENTTY---TGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDAL 283
             EE E++++       P+V     S   ++  K       K ++   K  G ++  D  
Sbjct: 112 DSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNS 171

Query: 284 SSDFTCGSPTAAGKK-TEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEAL 342
                     ++G+   E +E  +  K Q         P  E   + +  +   + +   
Sbjct: 172 KKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQK 231

Query: 343 SASLGTRQA----EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGK 398
            A    R+     E +  LR +KE +E +  ++   K  E       E      T   G 
Sbjct: 232 KAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTG- 290

Query: 399 PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 458
            ++P  EEK +  + +E  D+   D  + + K+K  +  EK +E K              
Sbjct: 291 -VIPASEEKAETPTAAE--DDNEGDKKKKDKKKKKGEKEEKEKEKKKG------------ 335

Query: 459 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 518
                    P  AT+K     +A+  L +   +++ + E+    +++++ K KEE+R + 
Sbjct: 336 ---------PSKATVKAM--QEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQ 384

Query: 519 GEKEETIPPDYRLEEVKDKDGKPLLPKE----------------------SKEQLP---P 553
            ++E     +   +E   K+GK L   +                      SK+ LP   P
Sbjct: 385 EKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRP 444

Query: 554 MSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAS--TTQAGAPPRDTSQS 611
           + ED     + +     + + S++     L AA+  +    P    T     P  +    
Sbjct: 445 IYEDKKRKKIPQQLESKEVSESME-----LCAAVEVMEQGVPEKEETPPPVEPEEEEDTE 499

Query: 612 DKDLDDALDKLSDSLGQR---------------QPDPDENKPMEDKVKEKAKAEHRDKLG 656
           D  LDD     SD   ++               + + +E +  ED+  E+ + E  +  G
Sbjct: 500 DAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEG 559

Query: 657 ----ERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADD 695
               E D+ +  E      D+G+    KP  + S DS+  +DD
Sbjct: 560 SEGDEEDEKVSDE-----KDSGKTLDKKPSKEMSSDSEYDSDD 597



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 100/479 (20%), Positives = 169/479 (35%), Gaps = 68/479 (14%)

Query: 30  KTSESPSKPGEKK--GSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPT 87
           K ++  ++   KK  GS+E +  S    + SR  + G +             +  +    
Sbjct: 148 KKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNK 207

Query: 88  ETKAVKTEPEKKSQSTKLSVVHEKKSQ--EGKPKEHTEPKSL-----PKQASDTGSNDAH 140
               +++  E    S K+  V +KK++  E + K+  E K+       K+  +TG  D  
Sbjct: 208 PGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQS 267

Query: 141 NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISG-KPGDKKKEKKSLTPAV 199
            +K   R  E++  +      T    +I A  E     TA      GDKKK+ K      
Sbjct: 268 KQKESQRKFEEETVKSKVTVDT---GVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGE 324

Query: 200 PVESKPDKPSGKSGMDA-ALDDLIDTLGGPEET--------------------EEENTTY 238
             E + +K  G S     A+ + +  L   EE                     EEE    
Sbjct: 325 KEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQ 384

Query: 239 TGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGS------P 292
              E          E L K    +    RE  A+       + A   +           P
Sbjct: 385 EKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRP 444

Query: 293 TAAGKKTEK----------EESTEVLKA-----QSAGTVRSAAPPQEKKRKVEKDTMSDQ 337
               KK +K           ES E+  A     Q         PP E + + + +     
Sbjct: 445 IYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLD 504

Query: 338 ALEALSASLGTRQAE-----------PELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSE 386
             EA+++   T + E           PE +    +E +E +  EE+ E+ GE + +   E
Sbjct: 505 DWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDE 564

Query: 387 YRLKPATDKD-GKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESK 444
              K + +KD GK L  +P ++    SE +  D+ +++ +R+  K K      + E SK
Sbjct: 565 EDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKE-ERAYDKAKRRIEKRRLEHSK 622



 Score = 37.0 bits (84), Expect = 0.068
 Identities = 40/168 (23%), Positives = 77/168 (45%), Gaps = 26/168 (15%)

Query: 607 DTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY 666
           D+++ D DLD    ++  +   ++ +P ++K  + K K+K   +  D L E ++ +  E 
Sbjct: 11  DSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE-LSLEA 69

Query: 667 RHL-----------LDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTET 715
           + +            ++N ++   K   KK +  KK + D +  + L  D DS       
Sbjct: 70  QGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELE-DKDS------K 122

Query: 716 SQNTAKDKCKKAASS------SKAPKNG-GKAKDSAKTTEETSKPKDD 756
           S+ TAK K +  + S      +K PK   GKA+ S K  + + + +D+
Sbjct: 123 SKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN 170


>gi|109637791 transcription factor-like nuclear regulator [Homo
            sapiens]
          Length = 2624

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 123/592 (20%), Positives = 225/592 (38%), Gaps = 67/592 (11%)

Query: 74   SSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASD 133
            S G T   S  + ++T   K   EK   +T L ++  + ++   P+  T      K    
Sbjct: 633  SQGKTESESKNSHSKTSVEKNHVEKDKMNT-LDILRMETTERENPEAETVSVLGEKNCLQ 691

Query: 134  TGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGIT-------AISGKPG 186
             GS     +    R   Q+P   + +   + + +IS   E  A +        A    P 
Sbjct: 692  EGSQLKALRPVQVRGRLQKPKPNAGKAAERKEILISQE-EIGANVEKNENESCADRDTPQ 750

Query: 187  DKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDP 246
              + + +       V  +P+K      +      +++     +E  + N     P +   
Sbjct: 751  HMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTR 810

Query: 247  MSS---TYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEE 303
                        G+RE++      E+L K +   +   AL    T    T+  +    E 
Sbjct: 811  FQKPKPNIGRGTGRREIS---SKEEVLEKILVSGEMAAALRE--TVRLDTSPKEMVPAEI 865

Query: 304  STEVLKAQSAGTVRSAAPPQEKKRKVEKDTMS-DQALEALSASLGTRQAEPELDLRSIKE 362
            +T+ +++    T R A  P+EK   V  DT+  +  L+A+   +  R+  PE+       
Sbjct: 866  NTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEV------- 918

Query: 363  VDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSE 422
            +D  +  ++ LE+ G          R + +  K+G      PEE  KP  E E   +L  
Sbjct: 919  IDATEEIDKDLEEAG----------RREISPQKNG------PEEV-KPLGEVET--DLKA 959

Query: 423  DFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAV 482
              + S  +EK  + T+ TEE        + + +  T    I      P  +K   P D +
Sbjct: 960  TGNESSPREKTPEVTDATEE--------IDKNLEETGRRKISPRENGPEEVK---PVDEM 1008

Query: 483  EALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDK-DGKP 541
            E   ++ G++ +  E    V+D  +E   EE       + E  P +  LEEVK   + + 
Sbjct: 1009 ETDLNATGRESSPREKTPEVIDATEEIDLEET------EREVSPQENGLEEVKPLGEMET 1062

Query: 542  LLPKESKEQLPPMSEDFLLDALSE---DFSGPQNASSLKFEDAKLAAAISEVVSQTPAST 598
             L    ++  P      ++DA+ E   D    +   S +    +    + E+  QT    
Sbjct: 1063 DLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEM--QTDLKA 1120

Query: 599  TQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 650
            T     PR+ +    D  + +DK  +  G+R+  P+EN P E K  ++ + +
Sbjct: 1121 TGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETD 1172


>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
           homolog 2 [Homo sapiens]
          Length = 1210

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 118/561 (21%), Positives = 202/561 (36%), Gaps = 84/561 (14%)

Query: 28  SEKTSESP----SKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSS 83
           SE+T E P    + P   +   E  A++  SS  S + +   +S+   S SS  +S S  
Sbjct: 437 SEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESS--SSDSEE 494

Query: 84  MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDT-GSNDAHNK 142
             P ET A + EP   +   +L     K SQ   P E       P++  ++ GS+D+   
Sbjct: 495 NEPLETPAPEPEP-PTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATS 553

Query: 143 KAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVE 202
           +  S S +  P   S  P+  P+           G  +    P  ++  ++  T      
Sbjct: 554 QEHSESKDPPPKSSSKAPRAPPE-------APHPGKRSCQKSPAQQEPPQRQ-TVGTKQP 605

Query: 203 SKPDKPSGKSGMDAAL----DDLIDTLGGPEETEEEN-----------TTYTGPEVSDPM 247
            KP K S ++G   +L    +  +   G  ++T ++                 P+ + P 
Sbjct: 606 KKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPP 665

Query: 248 SSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTC-------GSP-TAAGKKT 299
           SS    E  K + ++P   + L       D+  D     F         G P + +G +T
Sbjct: 666 SS----EKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRT 721

Query: 300 EKEESTEVLKAQS--------------AGTVRSAAPPQEKKRKVEKDTMSDQALEALSAS 345
                  V++  S                 +R   PPQ    K+  D +S          
Sbjct: 722 SGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLS---RIPQPPG 778

Query: 346 LGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPA-TDKDGKPLLPEP 404
            G+RQ       R  ++      K+   EK   D  +  ++ R   A  D D K +  E 
Sbjct: 779 KGSRQ-------RKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEK 831

Query: 405 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 464
           E K +  S S    E S        K KPS+P+ ++ + +   P PVS +  + +  +++
Sbjct: 832 EIKSQSSSSSSSHKESS--------KTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALK 883

Query: 465 SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET 524
            +  E  T     P  A          K    +   P   +V+ K      E  G   +T
Sbjct: 884 RSRREADTCGQDPPKSASST-------KSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDT 936

Query: 525 IPPDYRLEEVKDKDGKPLLPK 545
             P + +  + + + KP  P+
Sbjct: 937 ANP-FPVPSLPNGNSKPGKPQ 956



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 125/637 (19%), Positives = 212/637 (33%), Gaps = 92/637 (14%)

Query: 66  ASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK 125
           +S T+       +SK+ S +   T ++  +  + S S         +         + P+
Sbjct: 396 SSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQ 455

Query: 126 SLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKP 185
           SLP+  +      AH+  A S S     S   +E ++   D  S   E +         P
Sbjct: 456 SLPEPVA-----SAHSSSAESESTSDSDSSSDSESESSSSD--SEENEPLETPAPEPEPP 508

Query: 186 GDKKKE-----KKSLTPAVPVE----SKPDK--PSGKSGMDAALDDLIDTLGGPEETEEE 234
              K +      K   PA P E    ++P +  P  K   D+A          P      
Sbjct: 509 TTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSS 568

Query: 235 NTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRE-LLAKPIGPDDAIDALSSDFTCGSPT 293
                 PE   P         GKR     P  +E    + +G       + +    GS T
Sbjct: 569 KAPRAPPEAPHP---------GKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRT 619

Query: 294 AAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEP 353
           +   + E+E     L    +    S   P+ K +   +   S++   A+  S   ++ + 
Sbjct: 620 SL--QGEREPG---LLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKS 674

Query: 354 ELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSE 413
            L   S K +   +  ++ +E      +  P  + L P T+  G P              
Sbjct: 675 SLPAPS-KALSGPEPAKDNVE------DRTPEHFALVPLTESQGPP-------------- 713

Query: 414 SELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATL 473
                        S C++       + +  K   P P+ +    T + S     P P +L
Sbjct: 714 -----HSGSGSRTSGCRQ---AVVVQEDSRKDRLPLPLRD----TKLLSPLRDTPPPQSL 761

Query: 474 KGTVPDDAVEALADSLGK--KEADPEDGKPVMDK--VKEKAKEEDREKLGEKEETIPPDY 529
              +  D +  +    GK  ++   ED +P   K    EK   +   KL +K +      
Sbjct: 762 MVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKG----- 816

Query: 530 RLEEVKDKDGKPL-LPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 588
             E  +D D K + L KE K Q    S      + ++  S P + SS K           
Sbjct: 817 --EAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKP-SRPSSQSSKK----------- 862

Query: 589 EVVSQTPASTTQAGAPPRDTSQSDKDLDD-ALDKLSDSLGQRQPDPDENKPMEDKVKEKA 647
           E++   P S++          +S ++ D    D    +   +    D + P + +V+ K 
Sbjct: 863 EMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKG 922

Query: 648 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTK 684
                +  G   DT  P     L  NG  KP KP  K
Sbjct: 923 SRSSSEHKGSSGDTANPFPVPSL-PNGNSKPGKPQVK 958



 Score = 35.0 bits (79), Expect = 0.26
 Identities = 46/202 (22%), Positives = 69/202 (34%), Gaps = 41/202 (20%)

Query: 571 QNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPP----------------RDTSQSDKD 614
           Q  SS+  +D +L+ +      QTP     + APP                   S+S  D
Sbjct: 417 QGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSD 476

Query: 615 LDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNG 674
            D + D  S+S      D +EN+P+E    E                 PP       DN 
Sbjct: 477 SDSSSDSESES---SSSDSEENEPLETPAPEPE---------------PPTTNKWQLDNW 518

Query: 675 QDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAP 734
             K  +P              + P    S D       + TSQ  ++ K     SSSKAP
Sbjct: 519 LTKVSQPAAPPEGPRSTEPPRRHPESKGSSD-------SATSQEHSESKDPPPKSSSKAP 571

Query: 735 KNGGKAKDSAKTTEETSKPKDD 756
           +   +A    K + + S  + +
Sbjct: 572 RAPPEAPHPGKRSCQKSPAQQE 593


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
            [Homo sapiens]
          Length = 1451

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 167/828 (20%), Positives = 304/828 (36%), Gaps = 107/828 (12%)

Query: 4    PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAAS---LGSSQSSRT 60
            PG+    +P  +  A A +T     E+ SES S+  E   S+E+  A+   L +  S +T
Sbjct: 311  PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSE--ESSDSEEETPAAKALLQAKASGKT 368

Query: 61   YAGGTASA-TKVSASSGAT-SKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKS----- 113
               G ASA  K S   GA  +      P   KA   + E+ SQS+      E+++     
Sbjct: 369  SQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAK 428

Query: 114  QEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGE 173
              GK  +     +  K++   G+  A  +K    +A+ Q  ++  + ++  ++   +  E
Sbjct: 429  PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES-DSDRE 487

Query: 174  SVAGITAISGKPGDKKKEKKSLTPAVPVESKP------DKPSGKSGMDAALDDLIDTLGG 227
            ++A + A   KP  K  + K   PA  +   P        P GK G       +      
Sbjct: 488  ALAAMNAAQVKPLGKSPQVK---PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEED 544

Query: 228  PEETEEENTTYTGPEVSDPMSSTYIEELGK----REVTIPPKYRELLAKPI--------- 274
             E + EE++  +  EV   ++    + LG     +  + P K     A P+         
Sbjct: 545  SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKP 604

Query: 275  -----GPDDAIDALSSDFTCGSPTAA-GKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRK 328
                   +++ D+  S+    + TAA  K   K   T+    ++  T  +   P     +
Sbjct: 605  MDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQ 664

Query: 329  VEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE------EKLEKCGEDDET 382
              +   +  +    S ++      P  D  S +E D  + K        + +  G+  + 
Sbjct: 665  APRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQV 724

Query: 383  IPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEE 442
              +   +K +  +   P+LP    K  P + +++  E  ED + SE         E   E
Sbjct: 725  KAASVPVKGSLGQGTAPVLP---GKTGP-TVTQVKAEKQEDSESSE--------EESDSE 772

Query: 443  SKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTV--PDDAVEALADSLGKKEAD----- 495
              AA+PA V  +V +T   +  +A   P+  KGT+  P   V A A +  +  +      
Sbjct: 773  EAAASPAQVKTSVKKTQAKANPAAARAPSA-KGTISAPGKVVTAAAQAKQRSPSKVKPPV 831

Query: 496  ----------------PEDGKPVMDKVK-EKAKEEDREKLGEKEETIPPDYRLEEVKDKD 538
                            P  GK V    + +   EED     E+ ++      L +VK   
Sbjct: 832  RNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVK-PS 890

Query: 539  GKPLLPKESKEQLPPMSEDFLLDA--LSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPA 596
            GK     + +  L P  E     A       +GP  A + K +D+  ++  S+   + PA
Sbjct: 891  GK---THQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPA 947

Query: 597  STTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLG 656
            + T A          D +   A    + +  Q    P + +  E   +  +     + + 
Sbjct: 948  AVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVI 1007

Query: 657  ERDDTIPPEYRHLLDDNGQDKPVKPP------------TKKSEDSKKPADDQDPIDALSG 704
                 + P  R  +       P   P            + +  D KK       +D+  G
Sbjct: 1008 PATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVG 1067

Query: 705  DL--DSCPSTTETSQNT---AKDKCKKAASSSKAPKNGGKAKDSAKTT 747
             L   S  ST+  ++ T    K K  +   ++KAP++   ++DS+ ++
Sbjct: 1068 TLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSS 1115



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 155/774 (20%), Positives = 257/774 (33%), Gaps = 117/774 (15%)

Query: 35   PSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKT 94
            P+ P  + G  E+ + S  SS+ S   + G        A   +        PT + A   
Sbjct: 531  PATPSAQVGKWEEDSES--SSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPA--K 586

Query: 95   EPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPS 154
             P +K+    + V  EK      P +++E     +++SD  S D+    A   +A+ +P+
Sbjct: 587  GPPQKAGPVAVQVKAEK------PMDNSESS---EESSD--SADSEEAPAAMTAAQAKPA 635

Query: 155  EKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKP------DKP 208
             K  + K  P+   +     VA +   +  P      +K+ T   P  S P       +P
Sbjct: 636  LKIPQTKACPKKTNTTASAKVAPVRVGTQAP------RKAGTATSPAGSSPAVAGGTQRP 689

Query: 209  SGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRE 268
            +  S      D   +  G      +  +   G +V    S      LG+    + P    
Sbjct: 690  AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVK-AASVPVKGSLGQGTAPVLPGKTG 748

Query: 269  LLAKPIGPDDAIDALSSDFTCGSPTAAG---------KKTEKEESTEVLKAQSA-GTVRS 318
                 +  +   D+ SS+    S  AA          KKT+ + +    +A SA GT+ +
Sbjct: 749  PTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA 808

Query: 319  -----AAPPQEKKR---KVEKDTMSDQALEALS-------------ASLGTRQAEPELDL 357
                  A  Q K+R   KV+    + Q    L+             A+    Q  PE D 
Sbjct: 809  PGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDS 868

Query: 358  RSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELI 417
             S +E  +++ + E L +     +T      L PA +   K   P P  K  P +     
Sbjct: 869  GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQA-- 926

Query: 418  DELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTV 477
                        K+  S  + +  +S   APA V+ A         Q   P P       
Sbjct: 927  -----------GKQDDSGSSSEESDSDGEAPAAVTSA---------QVIKP-PLIFVDPN 965

Query: 478  PDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDK 537
               A  A   +  +  + P   +      +  + E + E +    + + P  R   V   
Sbjct: 966  RSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMP 1025

Query: 538  DGKP-LLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPA 596
               P + PK S        E      +S+       A+ +      L A   +  S    
Sbjct: 1026 TAHPRIAPKASMAGASSSKES---SRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAK 1082

Query: 597  STTQAGAPP----RDTSQSDKDLDDALDKLSDSLGQRQPD--PDENKPMEDKV-----KE 645
             T +   P     +  +++ +  DD+ D    S G  +    P   K     V     + 
Sbjct: 1083 GTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRT 1142

Query: 646  KAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGD 705
            +   E        DD + P    L   +G   P   P         P             
Sbjct: 1143 ETLVEETAAESSEDDVVAPSQSLL---SGYMTPGLTPANSQASKATPK------------ 1187

Query: 706  LDSCPSTTET----SQNTAKDKCK-KAASSSKAPKNGGKAKDSAKTTEETSKPK 754
            LDS PS + T         K + K + A+   +PK GGK   S  T +++ KPK
Sbjct: 1188 LDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPK 1241



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 83/394 (21%), Positives = 144/394 (36%), Gaps = 76/394 (19%)

Query: 2    SQPGQKPAASPRPR--RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQ--- 56
            S  G  PA SP+    +A    +  +    +  ++   P     S++   +S GS +   
Sbjct: 1064 SAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGE 1123

Query: 57   ------SSRTYAGGTASATKVSASSGATSKSSS-----------------MNPTETKAVK 93
                  S+ T  G T S T+      A   S                   + P  ++A K
Sbjct: 1124 GPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASK 1183

Query: 94   TEPEKKSQSTKLSVVHEKKS----QEGKPKEHT---EPKSLPKQASDTGSNDAHNKKAVS 146
              P+  S  +  S +  K      QE KP++      PK+  K+A+ +G+    ++K   
Sbjct: 1184 ATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAA-SGTTPQKSRKPKK 1242

Query: 147  RSAEQQPSEKSTE------------PKTKPQ----------DMISAGGESVAGITAISGK 184
             +   Q S  + +            P  + Q          +++    + V   T  S +
Sbjct: 1243 GAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSR 1302

Query: 185  PG--DKKKEKKSLTPAV--PVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 240
             G   +K++     PA   P   K  K     G +A++         PE+T   +TT  G
Sbjct: 1303 KGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVS--------PEKT---STTSKG 1351

Query: 241  PEVSDPMSSTYIEELGKREVT---IPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGK 297
                D  S    E+ GK  +       +  E L K +G  +  D  +         +  +
Sbjct: 1352 KAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR 1411

Query: 298  KTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEK 331
            K +KE+  +  KA+ A T  S +P Q+KK+K +K
Sbjct: 1412 KKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKK 1445



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 93/447 (20%), Positives = 159/447 (35%), Gaps = 53/447 (11%)

Query: 340 EALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLE-KCGEDDETIPSEYRLKPATDKDGK 398
           +A S+S  T  +  E D+     V  A+ K   +  K     +  P+  ++   T +   
Sbjct: 195 QADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKG 254

Query: 399 PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPS-KPTEKTEESKAA-APAPVSEAVC 456
             LP  +   KP  ESE  +E SE  + +    +   K +EK  + +AA APA  +    
Sbjct: 255 GALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPG-- 312

Query: 457 RTSMCSIQSAPPEPATLKGTVPDDA----VEALADSLGKKEADPEDGKPVMDKVKEKAKE 512
                  + A P P    G V         E  ++S  ++ +D E+  P    + +    
Sbjct: 313 -------KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 365

Query: 513 EDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQN 572
               ++G          R        GK   P  +K Q     ED    +   D      
Sbjct: 366 GKTSQVGAASAPAKESPRKGAAPAPPGK-TGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424

Query: 573 ASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTS------QSDKDLDDALDKLSDSL 626
           A +     A    A S    ++P     A APPR T       Q  K  +D+     +S 
Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGA-APAPPRKTGPAAAQVQVGKQEEDSRSSSEESD 483

Query: 627 GQRQP----DPDENKPMEDKVKEK-AKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKP 681
             R+     +  + KP+    + K A       LG+    +PP         G+  P  P
Sbjct: 484 SDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPP---------GKVGPATP 534

Query: 682 PT---KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPK--- 735
                K  EDS+  +++    D+  G++ +  +  +        + K  +S +K P    
Sbjct: 535 SAQVGKWEEDSESSSEESS--DSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA 592

Query: 736 -------NGGKAKDSAKTTEETSKPKD 755
                     K  D+++++EE+S   D
Sbjct: 593 GPVAVQVKAEKPMDNSESSEESSDSAD 619



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 142/750 (18%), Positives = 251/750 (33%), Gaps = 82/750 (10%)

Query: 28   SEKTSESPSKPGEKKGSDEKKAASLGSSQSS--RTYAGGTASATKVSASSGATSKSSSMN 85
            +EK  +S S   E++   E+ AAS    ++S  +T A    +A +  ++ G  S    + 
Sbjct: 756  AEKQEDSESS--EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVV 813

Query: 86   PTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAV 145
                +A +  P K     +             P+  T     P      G       KAV
Sbjct: 814  TAAAQAKQRSPSKVKPPVR------------NPQNSTVLARGPASVPSVG-------KAV 854

Query: 146  SRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKE-KKSLTPAV--PVE 202
            + +A+ Q   +     ++ +       E++A +     KP  K  + + +L PA   P +
Sbjct: 855  ATAAQAQTGPEEDSGSSEEESDSEEEAETLAQV-----KPSGKTHQIRAALAPAKESPRK 909

Query: 203  SKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTI 262
                 P GK+G  AA     D  G   E  + +          P + T  + +    + +
Sbjct: 910  GAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDG-------EAPAAVTSAQVIKPPLIFV 962

Query: 263  PPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGT----VRS 318
             P  R        P  A  A +      S + A   + + E  +V+ A    T       
Sbjct: 963  DPN-RSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNV 1021

Query: 319  AAPPQEKKRKVEKDTMS--DQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKC 376
               P    R   K +M+    + E+   S G +Q  P        +VD A          
Sbjct: 1022 VTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPAT------QVDSA---------V 1066

Query: 377  GEDDETIPSEYRLKP-ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSK 435
            G    T P    ++   T+K  KP LPE ++  K    S+  ++ S+    SE   +  +
Sbjct: 1067 GTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQ 1126

Query: 436  PTEKTEESKAAAPAPVSEAVCRTSMCSIQS--APPEPATLKGTVPDDAVEALADSLGKKE 493
              +         P+     V  T+  S +     P  + L G +      A  +S   K 
Sbjct: 1127 GAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPA--NSQASKA 1184

Query: 494  ADPEDGKPVMDKVKEKAKEEDREKLGEKEET---IPPDYRLEEVKDKDGKPLLPKESKEQ 550
                D  P +        + D ++  + ++    + P    +E           K  K  
Sbjct: 1185 TPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGA 1244

Query: 551  LPPMSEDFLLDA-LSEDFSG---PQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPR 606
              P +    L + +++   G   P N + ++    K+   + E   +    TT+  +   
Sbjct: 1245 GNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKG 1304

Query: 607  DTSQSDKDLDDA------LDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDD 660
              S+  K   D         K    LG  +       P +     K KA+ RDK     D
Sbjct: 1305 WESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAK-RDKAS--GD 1361

Query: 661  TIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTA 720
                + +  L   G     +   +K   + +  D  +P  +      S     +  +   
Sbjct: 1362 VKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNP-KSKKEKKKSDKRKKDKEKKEK 1420

Query: 721  KDKCKKAASSSKAPKNGGKAKDSAKTTEET 750
            K K KKA++      +  K K   KT E+T
Sbjct: 1421 KKKAKKASTKDSESPSQKKKKKKKKTAEQT 1450


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.298    0.120    0.320 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,210,518
Number of Sequences: 37866
Number of extensions: 1890935
Number of successful extensions: 14858
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 162
Number of HSP's successfully gapped in prelim test: 1100
Number of HSP's that attempted gapping in prelim test: 9195
Number of HSP's gapped (non-prelim): 4826
length of query: 756
length of database: 18,247,518
effective HSP length: 110
effective length of query: 646
effective length of database: 14,082,258
effective search space: 9097138668
effective search space used: 9097138668
T: 11
A: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.