Search of human proteins with 8923896

Search of human proteins with 8923896

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|8923896 acyl-CoA synthetase short-chain family member 2
isoform 1 [Homo sapiens]
         (701 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|8923896 acyl-CoA synthetase short-chain family member 2 isofo...  1470   0.0  
gi|253970489 acyl-CoA synthetase short-chain family member 2 iso...  1461   0.0  
gi|28416953 acyl-CoA synthetase short-chain family member 1 [Hom...   613   e-175
gi|13375727 acyl-CoA synthetase short-chain family member 3 [Hom...   363   e-100
gi|31982927 acetoacetyl-CoA synthetase [Homo sapiens]                 206   8e-53
gi|42544132 SA hypertension-associated homolog isoform 1 [Homo s...   186   6e-47
gi|122937307 acyl-CoA synthetase medium-chain family member 4 [H...   183   5e-46
gi|38505220 acyl-CoA synthetase medium-chain family member 5 [Ho...   179   6e-45
gi|115511026 acyl-CoA synthetase medium-chain family member 1 [H...   164   2e-40
gi|58082049 acyl-CoA synthetase medium-chain family member 2A [H...   153   6e-37
gi|157311624 acyl-CoA synthetase medium-chain family member 2B [...   141   2e-33
gi|157311622 acyl-CoA synthetase medium-chain family member 2B [...   141   2e-33
gi|239756507 PREDICTED: similar to Acyl-coenzyme A synthetase AC...   136   6e-32
gi|239756505 PREDICTED: similar to Acyl-coenzyme A synthetase AC...   136   6e-32
gi|42544134 SA hypertension-associated homolog isoform 2 [Homo s...   104   3e-22
gi|187761345 acyl-CoA synthetase family member 3 [Homo sapiens]       103   7e-22
gi|187761343 acyl-CoA synthetase family member 3 [Homo sapiens]       103   7e-22
gi|195947378 acyl-coenzyme A synthetase ACSM6, mitochondrial [Ho...    78   2e-14
gi|40807357 solute carrier family 27 (fatty acid transporter), m...    70   9e-12
gi|38524616 solute carrier family 27, member 1 [Homo sapiens]          66   1e-10
gi|156151445 acyl-CoA synthetase family member 2 [Homo sapiens]        57   6e-08
gi|13325057 solute carrier family 27 (fatty acid transporter), m...    57   8e-08
gi|13236579 solute carrier family 27 member 3 [Homo sapiens]           51   3e-06
gi|62865631 solute carrier family 27 (fatty acid transporter), m...    50   7e-06
gi|13325055 solute carrier family 27 (fatty acid transporter), m...    50   7e-06
gi|45580730 aminoadipate-semialdehyde dehydrogenase [Homo sapiens]     47   6e-05
gi|227499619 solute carrier family 27 (fatty acid transporter), ...    43   0.001
gi|4758332 acyl-CoA synthetase long-chain family member 4 isofor...    39   0.021
gi|12669909 acyl-CoA synthetase long-chain family member 4 isofo...    39   0.021
gi|27477105 lipidosin [Homo sapiens]                                   36   0.11 

>gi|8923896 acyl-CoA synthetase short-chain family member 2 isoform
           1 [Homo sapiens]
          Length = 701

 Score = 1470 bits (3806), Expect = 0.0
 Identities = 701/701 (100%), Positives = 701/701 (100%)

Query: 1   MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE 60
           MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE
Sbjct: 1   MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE 60

Query: 61  FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK 120
           FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK
Sbjct: 61  FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK 120

Query: 121 VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC 180
           VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC
Sbjct: 121 VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC 180

Query: 181 ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK 240
           ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK
Sbjct: 181 ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK 240

Query: 241 GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDEC 300
           GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDEC
Sbjct: 241 GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDEC 300

Query: 301 EPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIG 360
           EPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIG
Sbjct: 301 EPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIG 360

Query: 361 WITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFG 420
           WITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFG
Sbjct: 361 WITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFG 420

Query: 421 DEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPG 480
           DEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPG
Sbjct: 421 DEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPG 480

Query: 481 ATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTY 540
           ATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTY
Sbjct: 481 ATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTY 540

Query: 541 FKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVV 600
           FKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVV
Sbjct: 541 FKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVV 600

Query: 601 GHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSG 660
           GHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSG
Sbjct: 601 GHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSG 660

Query: 661 KIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ 701
           KIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ
Sbjct: 661 KIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ 701


>gi|253970489 acyl-CoA synthetase short-chain family member 2
           isoform 2 [Homo sapiens]
          Length = 714

 Score = 1461 bits (3782), Expect = 0.0
 Identities = 701/714 (98%), Positives = 701/714 (98%), Gaps = 13/714 (1%)

Query: 1   MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE 60
           MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE
Sbjct: 1   MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE 60

Query: 61  FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK 120
           FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK
Sbjct: 61  FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK 120

Query: 121 VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC 180
           VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC
Sbjct: 121 VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC 180

Query: 181 ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK 240
           ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK
Sbjct: 181 ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK 240

Query: 241 GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQ-------------ISWNQGIDL 287
           GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQ             ISWNQGIDL
Sbjct: 241 GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQGKLKEKSKRVQPQISWNQGIDL 300

Query: 288 WWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDF 347
           WWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDF
Sbjct: 301 WWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDF 360

Query: 348 HAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFY 407
           HAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFY
Sbjct: 361 HAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFY 420

Query: 408 TAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQ 467
           TAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQ
Sbjct: 421 TAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQ 480

Query: 468 TETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMR 527
           TETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMR
Sbjct: 481 TETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMR 540

Query: 528 TVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESA 587
           TVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESA
Sbjct: 541 TVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESA 600

Query: 588 LVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDY 647
           LVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDY
Sbjct: 601 LVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDY 660

Query: 648 IQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ 701
           IQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ
Sbjct: 661 IQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ 714


>gi|28416953 acyl-CoA synthetase short-chain family member 1 [Homo
           sapiens]
          Length = 689

 Score =  613 bits (1581), Expect = e-175
 Identities = 320/696 (45%), Positives = 429/696 (61%), Gaps = 45/696 (6%)

Query: 8   VRSGSGSRGQEEAGAGGRARSWSPP----PEVSRSAHVPSLQRYRELHRRSVEEPREFWG 63
           +R  SG   +   G     R+ S P    P V+ +A  P    Y  L  ++  EP  FWG
Sbjct: 17  LRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPG--SYPALSAQAAREPAAFWG 74

Query: 64  DIAKE-FYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDKVA 122
            +A++   W TP       ++ D + GKI   W  G   N+  N LD+  H +K  + VA
Sbjct: 75  PLARDTLVWDTPY---HTVWDCDFSTGKI--GWFLGGQLNVSVNCLDQ--HVRKSPESVA 127

Query: 123 FYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACAR 182
             WE +EPG   +ITY +LL   C+ +N L++ G+ +GDRVAIYMP+ P  V AMLACAR
Sbjct: 128 LIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACAR 187

Query: 183 IGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEKGF 242
           IGA+H+++FAGFS+ESL  RI D+ C ++IT +   RG ++V LK++ DEA++ C     
Sbjct: 188 IGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHC----- 242

Query: 243 PVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDECEP 302
           P    ++V H    ++ MGD                      +D+   + M +    C P
Sbjct: 243 PTVQHVLVAHRTDNKVHMGD----------------------LDVPLEQEMAKEDPVCAP 280

Query: 303 EWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWI 362
           E   +ED LF+LYTSGSTG PKG+VHT  GY+LY A T K VFD    D+F C ADIGWI
Sbjct: 281 ESMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWI 340

Query: 363 TGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDE 422
           TGHSYV YGPL NGATSVLFE  P YP+  R W  V++ K+ +FY APTA+RLL+K+GD 
Sbjct: 341 TGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDA 400

Query: 423 PVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPG-- 480
            V K+ R+SL+ LG+VGEPIN EAW W HRVVG  RC +VDT+WQTETGG  + P P   
Sbjct: 401 WVKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEE 460

Query: 481 ATPMKPGSATFPFFGVAPAILNESGEELEG-EAEGYLVFKQPWPGIMRTVYGNHERFETT 539
              + P  A  PFFG+ P +++E G  +EG    G L   Q WPG+ RT+YG+H+RF   
Sbjct: 461 GAEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDA 520

Query: 540 YFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAV 599
           YFK +PGYY TGDG  R + GYY ITGR+DD++N+SGH L TAE+E A+ +H AV E+AV
Sbjct: 521 YFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAV 580

Query: 600 VGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRS 659
           +G+PH +KGE  + F+ + D    S  + +ELK  +  KI   A PD I     LPKTRS
Sbjct: 581 IGYPHDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRS 640

Query: 660 GKIMRRVLRKIAQND-HDLGDMSTVADPSVISHLFS 694
           GK+MRR+LRKI  ++  +LGD +T+ DPS+I+ + S
Sbjct: 641 GKVMRRLLRKIITSEAQELGDTTTLEDPSIIAEILS 676


>gi|13375727 acyl-CoA synthetase short-chain family member 3 [Homo
           sapiens]
          Length = 686

 Score =  363 bits (931), Expect = e-100
 Identities = 237/690 (34%), Positives = 346/690 (50%), Gaps = 61/690 (8%)

Query: 13  GSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPREFWGDIAKEFYWK 72
           G RG    G GGR           R+    S   Y+     SV +P  FWG  A++  W 
Sbjct: 41  GPRG----GLGGRG---------CRALSSGSGSEYKTHFAASVTDPERFWGKAAEQISWY 87

Query: 73  TPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGE 132
            P        +   T+      W      NICYN +DR++   K GDK+A  ++      
Sbjct: 88  KPWTKTLENKHSPSTR------WFVEGMLNICYNAVDRHIENGK-GDKIAIIYDSPVTNT 140

Query: 133 TTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFA 192
               TY ++L QV + + VL K GI+KGD V IYMPMIP+ +  MLACARIGA+HS++F 
Sbjct: 141 KATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFG 200

Query: 193 GFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKH 252
           GF+S+ L  RI      +++T        + V    L +EAL+  Q K  P +  I  + 
Sbjct: 201 GFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQHK--PDKILIYNR- 257

Query: 253 LGRAELGMGDSTSQSPPIKRSCPDVQ-ISWNQGIDLWWHELMQEA-GDECEPEWCDAEDP 310
                                 P+++ +    G DL W E M +A   +C P    +E P
Sbjct: 258 ----------------------PNMEAVPLAPGRDLDWDEEMAKAQSHDCVPVL--SEHP 293

Query: 311 LFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTY 370
           L+ILYTSG+TG PKGV+   GGY + +  +   ++     +V+W  +D+GW+ GHSY+ Y
Sbjct: 294 LYILYTSGTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICY 353

Query: 371 GPLANGATSVLFEGIPT-YPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKF--GDEPVTKH 427
           GPL +G T+VL+EG P   PD    + ++ ++ V   +TAPTAIR + +   G     ++
Sbjct: 354 GPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQY 413

Query: 428 SRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGATPMK-- 485
           S    + L   GE  + E   W   V    R P++D +WQTETG  +     G    K  
Sbjct: 414 SLTRFKTLFVAGERCDVETLEWSKNVF---RVPVLDHWWQTETGSPITASCVGLGNSKTP 470

Query: 486 -PGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPW-PGIMRTVYGNHERFETTYFKK 543
            PG A     G    IL+++ ++L+    G +V K P  PG    ++ N E F+  YF+K
Sbjct: 471 PPGQAGKSVPGYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEK 530

Query: 544 FPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHP 603
           FPGYY T D    D++GY ++  R+DD++NV+GH +S   +E +++ H  VA+ AVVG  
Sbjct: 531 FPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKE 590

Query: 604 HPVKGEC-LYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKI 662
            P+KG   L   V   D +    ++ EE+ K +R+ IGP+A          LPKTRSGKI
Sbjct: 591 DPLKGHVPLALCVLRKDINATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKI 650

Query: 663 MRRVLRKIAQNDHDLGDMSTVADPSVISHL 692
            R  L  I  N       ST+ DPS+  H+
Sbjct: 651 PRSALSAIV-NGKPYKITSTIEDPSIFGHV 679


>gi|31982927 acetoacetyl-CoA synthetase [Homo sapiens]
          Length = 672

 Score =  206 bits (523), Expect = 8e-53
 Identities = 168/640 (26%), Positives = 289/640 (45%), Gaps = 52/640 (8%)

Query: 43  SLQRYRELHRRSVEEPREFWGDIAKEFYWKTPCPGPFLRYN--FDVTKGKIFI-EWMKGA 99
           +L+ Y +L+  SVE   +FW +     +WK         Y+   D +KG   + EW KG+
Sbjct: 43  ALESYDDLYHWSVESYSDFWAE-----FWKFSGIVFSRVYDEVVDTSKGIADVPEWFKGS 97

Query: 100 TTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQK 159
             N   N+L       K  D+VA Y       E  ++T+ +L  +V  F+  +RK G++K
Sbjct: 98  RLNYAENLL-----RHKENDRVALYIAREGKEEIVKVTFEELRQEVALFAAAMRKMGVKK 152

Query: 160 GDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAF-Y 218
           GDRV  Y+P     V AMLA A IGA+ S     F    + +R       L+ + +A  Y
Sbjct: 153 GDRVVGYLPNSEHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVY 212

Query: 219 RGEKLVNLKELADEALQKCQEKGFP-VRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDV 277
            G++  ++++L          KG P ++  +V+ ++   E               +    
Sbjct: 213 NGKEHNHMEKLQQVV------KGLPDLKKVVVIPYVSSRE---------------NIDLS 251

Query: 278 QISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYV 337
           +I  +  +D +      E   + E E      PLFI+++SG+TG PK +VH+ GG ++  
Sbjct: 252 KIPNSVFLDDFLATGTSEQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQH 311

Query: 338 ATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSI 397
                   +  + D+  C   +GW+  +  V+   LA GA  VL++G P  P  N LW +
Sbjct: 312 LKEHLLHGNMTSSDILLCYTTVGWMMWNWMVSL--LATGAAMVLYDGSPLVPTPNVLWDL 369

Query: 398 VDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQ 457
           VD+  +T   T    + +L +   +PV  HS   L  + + G P+  +++ + +R + + 
Sbjct: 370 VDRIGITVLVTGAKWLSVLEEKAMKPVETHSLQMLHTILSTGSPLKAQSYEYVYRCIKSS 429

Query: 458 RCPIVDTFWQTETGGHMLTPLPG---ATPMKPGSATFPFFGVAPAILNESGEELEGEAEG 514
                        G  +++   G   + P+  G       G+A    NE G+ + GE+ G
Sbjct: 430 -----ILLGSISGGTDIISCFMGHNFSLPVYKGEIQARNLGMAVEAWNEEGKAVWGES-G 483

Query: 515 YLVFKQPWPGIMRTVYGNHE---RFETTYFKKFPGYYVTGDGCQ-RDQDGYYWITGRIDD 570
            LV  +P P    T + N E   ++   YF KFPG +  GD C+   + G   + GR D 
Sbjct: 484 ELVCTKPIP-CQPTHFWNDENGNKYRKAYFSKFPGIWAHGDYCRINPKTGGIVMLGRSDG 542

Query: 571 MLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEE 630
            LN +G    ++E+ + +   E V ++  V   +  + E +  F+ +  GH F P L + 
Sbjct: 543 TLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILFLKMASGHAFQPDLVKR 602

Query: 631 LKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKI 670
           ++  IR  +     P  I    G+P T +GK +   +++I
Sbjct: 603 IRDAIRMGLSARHVPSLILETKGIPYTLNGKKVEVAVKQI 642


>gi|42544132 SA hypertension-associated homolog isoform 1 [Homo
           sapiens]
          Length = 586

 Score =  186 bits (472), Expect = 6e-47
 Identities = 159/578 (27%), Positives = 260/578 (44%), Gaps = 66/578 (11%)

Query: 102 NICYNVLDRNVHEKKLGDKV---AFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQ-GI 157
           N   +VLD+   ++K G K    AF+W  N  GE  + ++ +L     +F+N+L +   +
Sbjct: 59  NFAKDVLDQWTDKEKAGKKPSNPAFWWI-NRNGEEMRWSFEELGSLSRKFANILSEACSL 117

Query: 158 QKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAF 217
           Q+GDRV + +P +PE  +A +AC R G +        + + +  R+  S  + +IT D  
Sbjct: 118 QRGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKANCIITNDV- 176

Query: 218 YRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDV 277
                   L    D    KC+     +   ++V    R   G G+               
Sbjct: 177 --------LAPAVDAVASKCEN----LHSKLIVSENSRE--GWGNLK------------- 209

Query: 278 QISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYV 337
                        ELM+ A D          + + I +TSG++G PK   HT   + L +
Sbjct: 210 -------------ELMKHASDSHTCVKTKHNEIMAIFFTSGTSGYPKMTAHTHSSFGLGL 256

Query: 338 ATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSI 397
           +   ++  D    DV W T+D GW        + P   GA  V    +P +   + L ++
Sbjct: 257 SVNGRFWLDLTPSDVMWNTSDTGWAKSAWSSVFSPWIQGAC-VFTHHLPRFEPTSILQTL 315

Query: 398 VDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQ 457
             KY +T F +APT  R+L++     +T +   SL+   + GEPI P+    +    G  
Sbjct: 316 -SKYPITVFCSAPTVYRMLVQ---NDITSYKFKSLKHCVSAGEPITPDVTEKWRNKTGLD 371

Query: 458 RCPIVDTFWQTETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEEL----EGEAE 513
              I + + QTET   ++        +KPGS   P       I++ +G  L    EG+  
Sbjct: 372 ---IYEGYGQTETV--LICGNFKGMKIKPGSMGKPSPAFDVKIVDVNGNVLPPGQEGDIG 426

Query: 514 GYLVFKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLN 573
             ++  +P+ G+      N  +  +T    F   Y+TGD    D+DGY+W   R DD++ 
Sbjct: 427 IQVLPNRPF-GLFTHYVDNPSKTASTLRGNF---YITGDRGYMDKDGYFWFVARADDVIL 482

Query: 574 VSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTF--SPKLTEEL 631
            SG+ +   EVE+AL EH +VAE+AVV  P P++GE +  FV L   +      +L +E+
Sbjct: 483 SSGYRIGPFEVENALNEHPSVAESAVVSSPDPIRGEVVKAFVVLNPDYKSHDQEQLIKEI 542

Query: 632 KKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRK 669
           ++ +++   P   P  ++    LPKT SGK  R  LRK
Sbjct: 543 QEHVKKTTAPYKYPRKVEFIQELPKTISGKTKRNELRK 580


>gi|122937307 acyl-CoA synthetase medium-chain family member 4 [Homo
           sapiens]
          Length = 580

 Score =  183 bits (464), Expect = 5e-46
 Identities = 158/576 (27%), Positives = 260/576 (45%), Gaps = 64/576 (11%)

Query: 102 NICYNVLDRNVHEKKLGDKVA--FYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQ-GIQ 158
           N   +VLD+   ++K G++ A    W  N  G+  + ++ +L     + +NVL K  G+Q
Sbjct: 53  NFAADVLDQWSQKEKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAANVLTKPCGLQ 112

Query: 159 KGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFY 218
           +GDR+A+ +P IPE  +  +AC R G +        +++ +  R+  S    ++ ++   
Sbjct: 113 RGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASE--- 169

Query: 219 RGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQ 278
                    E+A            P    IV+               + P +K       
Sbjct: 170 ---------EVA------------PAVESIVL---------------ECPDLKTKLLVSP 193

Query: 279 ISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVA 338
            SWN  +   + EL Q A +E       +++P+ I +TSG+TG PK   H+     +   
Sbjct: 194 QSWNGWLS--FQELFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKMAQHSQSSLGIGFT 251

Query: 339 TTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIV 398
              +Y  D  + D+ W  +D GW+       +     GA   +F       D +     +
Sbjct: 252 LCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGAC--VFVHRMAQFDTDTFLDTL 309

Query: 399 DKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQR 458
             Y +T   + PT  R+L++   + + ++   SL+   T GEP+NPE    +    G + 
Sbjct: 310 TTYPITTLCSPPTVYRMLVQ---KDLKRYKFKSLRHCLTGGEPLNPEVLEQWRVQTGLE- 365

Query: 459 CPIVDTFWQTETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVF 518
             + + + QTE G  M+        +KPGS           I++E+G  L    EG +  
Sbjct: 366 --LYEGYGQTEVG--MICANQKGQEIKPGSMGKGMLPYDVQIIDENGNVLPPGKEGEIAL 421

Query: 519 K----QPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNV 574
           +    +P+    + V  N ++   T    F   YVTGD    D DGY+W  GR DD++  
Sbjct: 422 RLKPTRPFCFFSKYV-DNPQKTAATIRGDF---YVTGDRGVMDSDGYFWFVGRADDVIIS 477

Query: 575 SGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTL-CDGHTFSP-KLTEELK 632
           SG+ +   EVESAL+EH AV E+AVV  P  ++GE +  FV L     +++P KLT EL+
Sbjct: 478 SGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSYNPEKLTLELQ 537

Query: 633 KQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLR 668
             +++   P   P  ++    LPKT +GKI R VLR
Sbjct: 538 DHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVLR 573


>gi|38505220 acyl-CoA synthetase medium-chain family member 5 [Homo
           sapiens]
          Length = 579

 Score =  179 bits (455), Expect = 6e-45
 Identities = 162/576 (28%), Positives = 264/576 (45%), Gaps = 65/576 (11%)

Query: 102 NICYNVLDRNVHEKKLGDKV---AFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQ-GI 157
           N  ++VLD     ++ G +    AF+W  N  G   + ++ +L  Q  + +NVL    G+
Sbjct: 54  NFAHDVLDVWSRLEEAGHRPPNPAFWWV-NGTGAEIKWSFEELGKQSRKAANVLGGACGL 112

Query: 158 QKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAF 217
           Q GDR+ + +P +PE  +  +AC R G +        + + L  R+  S    +IT+D+ 
Sbjct: 113 QPGDRMMLVLPRLPEWWLVSVACMRTGTVMIPGVTQLTEKDLKYRLQASRAKSIITSDS- 171

Query: 218 YRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDV 277
                   L    D    +C                 + +L + DS+             
Sbjct: 172 --------LAPRVDAISAECPSL--------------QTKLLVSDSSRPG---------- 199

Query: 278 QISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYML-Y 336
              W     L + EL++EA  E       + DPL I +TSG+TG PK V H+   Y L +
Sbjct: 200 ---W-----LNFRELLREASTEHNCMRTKSRDPLAIYFTSGTTGAPKMVEHSQSSYGLGF 251

Query: 337 VATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWS 396
           VA+  ++V      D+FW T D GW+   ++  +    NG+   + E +P   D   + +
Sbjct: 252 VASGRRWVA-LTESDIFWNTTDTGWVKA-AWTLFSAWPNGSCIFVHE-LPRV-DAKVILN 307

Query: 397 IVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGA 456
            + K+ +T     PT  RLL++   E +T++   SL+   T GE +NP+    +    G 
Sbjct: 308 TLSKFPITTLCCVPTIFRLLVQ---EDLTRYQFQSLRHCLTGGEALNPDVREKWKHQTGV 364

Query: 457 QRCPIVDTFWQTETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYL 516
           +   + + + Q+ET   ++   P    +K GS           I+++ G  L    EG +
Sbjct: 365 E---LYEGYGQSETV--VICANPKGMKIKSGSMGKASPPYDVQIVDDEGNVLPPGEEGNV 419

Query: 517 V--FKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNV 574
               +   P      Y ++   E T   +   +Y+TGD  + D+DGY+W  GR DD++N 
Sbjct: 420 AVRIRPTRPFCFFNCYLDNP--EKTAASEQGDFYITGDRARMDKDGYFWFMGRNDDVINS 477

Query: 575 SGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGH-TFSPK-LTEELK 632
           S + +   EVESAL EH AV E+AVV  P P++GE +  F+ L   + +  P+ LT EL+
Sbjct: 478 SSYRIGPVEVESALAEHPAVLESAVVSSPDPIRGEVVKAFIVLTPAYSSHDPEALTRELQ 537

Query: 633 KQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLR 668
           + ++    P   P  +     LPKT SGKI R  LR
Sbjct: 538 EHVKRVTAPYKYPRKVAFVSELPKTVSGKIQRSKLR 573


>gi|115511026 acyl-CoA synthetase medium-chain family member 1 [Homo
           sapiens]
          Length = 577

 Score =  164 bits (416), Expect = 2e-40
 Identities = 163/622 (26%), Positives = 263/622 (42%), Gaps = 69/622 (11%)

Query: 59  REFWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLD---RNVHEK 115
           R  WG I K F+   P P      +        + ++      N    VLD   +   E 
Sbjct: 8   RTLWG-IHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLDYWAQKEKEG 66

Query: 116 KLGDKVAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQ-GIQKGDRVAIYMPMIPELV 174
           K G   AF+W  N  G+  + ++ ++     + +NV  +  G+Q+GD +A+ +P +PE  
Sbjct: 67  KRGPNPAFWWV-NGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEWW 125

Query: 175 VAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEAL 234
           +  + C R G +         ++ +  R+  S    ++T DA            LA E  
Sbjct: 126 LVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDA------------LASE-- 171

Query: 235 QKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQ 294
                                    +    SQ P +K        S    +D  +  L++
Sbjct: 172 -------------------------VDSIASQCPSLKTKLLVSDHSREGWLD--FRSLVK 204

Query: 295 EAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFW 354
            A  E         DP+ I +TSG+TG PK   H+ G  +       + +      DV W
Sbjct: 205 SASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSLKTSDVSW 264

Query: 355 CTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIR 414
           C +D GWI    +    P   G T V    +P + D   +   + KY +  F+   +  R
Sbjct: 265 CLSDSGWIVATIWTLVEPWTAGCT-VFIHHLPQF-DTKVIIQTLLKYPINHFWGVSSIYR 322

Query: 415 LLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHM 474
           ++++   +  T     +L+   T GE + P+    + R  G     + + + Q+ETG  +
Sbjct: 323 MILQ---QDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTGLL---LYENYGQSETG--L 374

Query: 475 LTPLPGATPMKPG---SATFPFFGVAPAILNESGEELEGEAEGYLVF--KQPWPGIMRTV 529
           +        +KPG    AT P+      ++++ G  L    EG +    K   P  +   
Sbjct: 375 ICATYWGMKIKPGFMGKATPPY---DVQVIDDKGSILPPNTEGNIGIRIKPVRPVSLFMC 431

Query: 530 YGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALV 589
           Y      E T   +   +Y TGD  + D++GY    GR DD++N SG+ +  AEVESALV
Sbjct: 432 YEGDP--EKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVESALV 489

Query: 590 EHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPK--LTEELKKQIREKIGPIATPDY 647
           EH AVAE+AVVG P P++GE +  F+ L        K  LT+EL++ ++    P   P  
Sbjct: 490 EHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRK 549

Query: 648 IQNAPGLPKTRSGKIMRRVLRK 669
           ++    LPKT +GKI R+ LRK
Sbjct: 550 VEFVSELPKTITGKIERKELRK 571


>gi|58082049 acyl-CoA synthetase medium-chain family member 2A [Homo
           sapiens]
          Length = 577

 Score =  153 bits (386), Expect = 6e-37
 Identities = 152/587 (25%), Positives = 248/587 (42%), Gaps = 81/587 (13%)

Query: 99  ATTNICYNVLDRNVHEKKLGDKV---AFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQ 155
           A  N   +VLD     +K G ++   A +W  N  G+     + +L     Q +NVL   
Sbjct: 42  AKFNFASDVLDHWADMEKAGKRLPSPALWWV-NGKGKELMWNFRELSENSQQAANVLSGA 100

Query: 156 -GIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITT 214
            G+Q+GDRVA+ +P +PE  + +L C R G +         S  +  R+  S    ++  
Sbjct: 101 CGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVA- 159

Query: 215 DAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSC 274
                           DE +Q+                                 +   C
Sbjct: 160 ---------------GDEVIQEVDT------------------------------VASEC 174

Query: 275 PDVQISW---NQGIDLW--WHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHT 329
           P ++I      +  D W  + +L+ EA          +++   I +TSG++G PK   H+
Sbjct: 175 PSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHS 234

Query: 330 VGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYP 389
                L       +     A D+ W  +D GWI         P A GA + +   +P + 
Sbjct: 235 YSSLGLKAKMDAGWT-GLQASDIMWTISDTGWILNILCSLMEPWALGACTFVHL-LPKF- 291

Query: 390 DVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLW 449
           D   +   +  Y +     AP   R+L++   + ++ +    LQ   TVGE + PE    
Sbjct: 292 DPLVILKTLSSYPIKSMMGAPIVYRMLLQ---QDLSSYKFPHLQNCVTVGESLLPETLEN 348

Query: 450 YHRVVGAQRCPIVDTFWQTETGGHMLTPLPGAT-PMKPGSATFPFFGVAPA-----ILNE 503
           +    G     I +++ QTETG   LT +   T  +KPG     + G A +     I+++
Sbjct: 349 WRAQTGLD---IRESYGQTETG---LTCMVSKTMKIKPG-----YMGTAASCYDVQIIDD 397

Query: 504 SGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYW 563
            G  L    EG +  +      +    G  +  + T       +++ GD   +D+DGY+ 
Sbjct: 398 KGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLGDRGIKDEDGYFQ 457

Query: 564 ITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGH-T 622
             GR DD++N SG+ +  +EVE+AL+EH AV E AV+  P PV+GE +  FV L     +
Sbjct: 458 FMGRADDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVVKAFVVLASQFLS 517

Query: 623 FSP-KLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLR 668
             P +LT+EL++ ++    P   P  I+    LPKT +GKI R  LR
Sbjct: 518 HDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRAKLR 564


>gi|157311624 acyl-CoA synthetase medium-chain family member 2B
           [Homo sapiens]
          Length = 577

 Score =  141 bits (355), Expect = 2e-33
 Identities = 147/589 (24%), Positives = 242/589 (41%), Gaps = 85/589 (14%)

Query: 99  ATTNICYNVLDRNVHEKKLGDKV---AFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQ 155
           A  N   +VLD     +K G ++   A +W  N  G+     + +L     Q +N+L   
Sbjct: 42  AKFNFASDVLDHWADMEKAGKRLPSPALWWV-NGKGKELMWNFRELSENSQQAANILSGA 100

Query: 156 -GIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITT 214
            G+Q+GDRVA+ +P +PE  + +L C R G +         S  +  R+  S    ++  
Sbjct: 101 CGLQRGDRVAVMLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVA- 159

Query: 215 DAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSC 274
                           DE +Q+                                 +   C
Sbjct: 160 ---------------GDEVIQEVDT------------------------------VASEC 174

Query: 275 PDVQISW---NQGIDLW--WHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHT 329
           P ++I      +  D W  + +L+ EA          +++   I +TSG++G PK   H+
Sbjct: 175 PSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHS 234

Query: 330 VGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYP 389
                L       +     A D+ W  +D GWI        G L    T      +   P
Sbjct: 235 YSSLGLKAKMDAGWT-GLQASDIMWTISDTGWILN----ILGSLLESWTLGACTFVHLLP 289

Query: 390 DVNRLWSI--VDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAW 447
             + L  +  +  Y +     AP   R+L++   + ++ +    LQ     GE + PE  
Sbjct: 290 KFDPLVILKTLSSYPIKSMMGAPIVYRMLLQ---QDLSSYKFPHLQNCLAGGESLLPETL 346

Query: 448 LWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGAT-PMKPGSATFPFFGVAPA-----IL 501
             +    G     I + + QTETG   LT +   T  +KPG     + G A +     ++
Sbjct: 347 ENWRAQTGLD---IREFYGQTETG---LTCMVSKTMKIKPG-----YMGTAASCYDVQVI 395

Query: 502 NESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGY 561
           ++ G  L    EG +  +      +    G  E  + T       +++ GD   +D+DGY
Sbjct: 396 DDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVENPDKTAANIRGDFWLLGDRGIKDEDGY 455

Query: 562 YWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGH 621
           +   GR DD++N SG+ +  +EVE+AL++H AV E AV+  P PV+GE +  FV L    
Sbjct: 456 FQFMGRADDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQF 515

Query: 622 -TFSP-KLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLR 668
            +  P +LT+EL++ ++    P   P  I+    LPKT +GKI R  LR
Sbjct: 516 LSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLR 564


>gi|157311622 acyl-CoA synthetase medium-chain family member 2B
           [Homo sapiens]
          Length = 577

 Score =  141 bits (355), Expect = 2e-33
 Identities = 147/589 (24%), Positives = 242/589 (41%), Gaps = 85/589 (14%)

Query: 99  ATTNICYNVLDRNVHEKKLGDKV---AFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQ 155
           A  N   +VLD     +K G ++   A +W  N  G+     + +L     Q +N+L   
Sbjct: 42  AKFNFASDVLDHWADMEKAGKRLPSPALWWV-NGKGKELMWNFRELSENSQQAANILSGA 100

Query: 156 -GIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITT 214
            G+Q+GDRVA+ +P +PE  + +L C R G +         S  +  R+  S    ++  
Sbjct: 101 CGLQRGDRVAVMLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVA- 159

Query: 215 DAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSC 274
                           DE +Q+                                 +   C
Sbjct: 160 ---------------GDEVIQEVDT------------------------------VASEC 174

Query: 275 PDVQISW---NQGIDLW--WHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHT 329
           P ++I      +  D W  + +L+ EA          +++   I +TSG++G PK   H+
Sbjct: 175 PSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHS 234

Query: 330 VGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYP 389
                L       +     A D+ W  +D GWI        G L    T      +   P
Sbjct: 235 YSSLGLKAKMDAGWT-GLQASDIMWTISDTGWILN----ILGSLLESWTLGACTFVHLLP 289

Query: 390 DVNRLWSI--VDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAW 447
             + L  +  +  Y +     AP   R+L++   + ++ +    LQ     GE + PE  
Sbjct: 290 KFDPLVILKTLSSYPIKSMMGAPIVYRMLLQ---QDLSSYKFPHLQNCLAGGESLLPETL 346

Query: 448 LWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGAT-PMKPGSATFPFFGVAPA-----IL 501
             +    G     I + + QTETG   LT +   T  +KPG     + G A +     ++
Sbjct: 347 ENWRAQTGLD---IREFYGQTETG---LTCMVSKTMKIKPG-----YMGTAASCYDVQVI 395

Query: 502 NESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGY 561
           ++ G  L    EG +  +      +    G  E  + T       +++ GD   +D+DGY
Sbjct: 396 DDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVENPDKTAANIRGDFWLLGDRGIKDEDGY 455

Query: 562 YWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGH 621
           +   GR DD++N SG+ +  +EVE+AL++H AV E AV+  P PV+GE +  FV L    
Sbjct: 456 FQFMGRADDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQF 515

Query: 622 -TFSP-KLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLR 668
            +  P +LT+EL++ ++    P   P  I+    LPKT +GKI R  LR
Sbjct: 516 LSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLR 564


>gi|239756507 PREDICTED: similar to Acyl-coenzyme A synthetase
           ACSM2B, mitochondrial isoform 2 [Homo sapiens]
          Length = 571

 Score =  136 bits (343), Expect = 6e-32
 Identities = 148/591 (25%), Positives = 240/591 (40%), Gaps = 95/591 (16%)

Query: 99  ATTNICYNVLDRNVHEKKLGDKV---AFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQ 155
           A  N   +VLD     +K G ++   A +W  N  G+     + +L     Q +NVL   
Sbjct: 42  AKFNFASDVLDHWADMEKAGKRLPSPALWWV-NGKGKELMWNFRELSENSQQAANVLSGA 100

Query: 156 -GIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITT 214
            G+Q+GDRVA+ +P +PE  + +L C R G +         S  +  R+  S    ++  
Sbjct: 101 CGLQRGDRVAVMLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVA- 159

Query: 215 DAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSC 274
                           DE +Q+                                 +   C
Sbjct: 160 ---------------GDEVIQEVDT------------------------------VASEC 174

Query: 275 PDVQISW---NQGIDLW--WHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHT 329
           P ++I      +  D W  + +L+ EA          +++   I +TSG++G PK   H+
Sbjct: 175 PSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHS 234

Query: 330 VGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYP 389
                L       +     A D+ W  +D GWI        G L    T      +   P
Sbjct: 235 YSSLGLKAKMDAGWT-GLQASDIMWTISDTGWILN----ILGSLLESWTLGACTFVHLLP 289

Query: 390 DVNRLWSI--VDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAW 447
             + L  +  +  Y +     AP   R+L++   + ++ +    LQ     GE + PE  
Sbjct: 290 KFDPLVILKTLSSYPIKSMMGAPIVYRMLLQ---QDLSSYKFPHLQNCLAGGESLLPETL 346

Query: 448 LWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGAT-PMKPGSATFPFFGVAPAILNES-- 504
             +    G     I + + QTETG   LT +   T  +KPG     + G A +  +    
Sbjct: 347 ENWRAQTGLD---IREFYGQTETG---LTCMVSKTMKIKPG-----YMGTAASCYDVQVI 395

Query: 505 ----GEELEGEAEGYLVFKQPWPGIMRTVY-GNHERFETTYFKKFPGYYVTGDGCQRDQD 559
               G    G+          + G M   + G+ E  + T       +++ GD   +D+D
Sbjct: 396 AFVHGSPRAGDLG--------FAGTMTLSFCGHQENPDKTAANIRGDFWLLGDRGIKDED 447

Query: 560 GYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCD 619
           GY+   GR DD++N SG+ +  +EVE+AL++H AV E AV+  P PV+GE +  FV L  
Sbjct: 448 GYFQFMGRADDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILAS 507

Query: 620 GH-TFSP-KLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLR 668
              +  P +LT+EL++ ++    P   P  I+    LPKT +GKI R  LR
Sbjct: 508 QFLSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLR 558


>gi|239756505 PREDICTED: similar to Acyl-coenzyme A synthetase
           ACSM2B, mitochondrial isoform 1 [Homo sapiens]
          Length = 571

 Score =  136 bits (343), Expect = 6e-32
 Identities = 148/591 (25%), Positives = 240/591 (40%), Gaps = 95/591 (16%)

Query: 99  ATTNICYNVLDRNVHEKKLGDKV---AFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQ 155
           A  N   +VLD     +K G ++   A +W  N  G+     + +L     Q +NVL   
Sbjct: 42  AKFNFASDVLDHWADMEKAGKRLPSPALWWV-NGKGKELMWNFRELSENSQQAANVLSGA 100

Query: 156 -GIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITT 214
            G+Q+GDRVA+ +P +PE  + +L C R G +         S  +  R+  S    ++  
Sbjct: 101 CGLQRGDRVAVMLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVA- 159

Query: 215 DAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSC 274
                           DE +Q+                                 +   C
Sbjct: 160 ---------------GDEVIQEVDT------------------------------VASEC 174

Query: 275 PDVQISW---NQGIDLW--WHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHT 329
           P ++I      +  D W  + +L+ EA          +++   I +TSG++G PK   H+
Sbjct: 175 PSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHS 234

Query: 330 VGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYP 389
                L       +     A D+ W  +D GWI        G L    T      +   P
Sbjct: 235 YSSLGLKAKMDAGWT-GLQASDIMWTISDTGWILN----ILGSLLESWTLGACTFVHLLP 289

Query: 390 DVNRLWSI--VDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAW 447
             + L  +  +  Y +     AP   R+L++   + ++ +    LQ     GE + PE  
Sbjct: 290 KFDPLVILKTLSSYPIKSMMGAPIVYRMLLQ---QDLSSYKFPHLQNCLAGGESLLPETL 346

Query: 448 LWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGAT-PMKPGSATFPFFGVAPAILNES-- 504
             +    G     I + + QTETG   LT +   T  +KPG     + G A +  +    
Sbjct: 347 ENWRAQTGLD---IREFYGQTETG---LTCMVSKTMKIKPG-----YMGTAASCYDVQVI 395

Query: 505 ----GEELEGEAEGYLVFKQPWPGIMRTVY-GNHERFETTYFKKFPGYYVTGDGCQRDQD 559
               G    G+          + G M   + G+ E  + T       +++ GD   +D+D
Sbjct: 396 AFVHGSPRAGDLG--------FAGTMTLSFCGHQENPDKTAANIRGDFWLLGDRGIKDED 447

Query: 560 GYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCD 619
           GY+   GR DD++N SG+ +  +EVE+AL++H AV E AV+  P PV+GE +  FV L  
Sbjct: 448 GYFQFMGRADDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILAS 507

Query: 620 GH-TFSP-KLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLR 668
              +  P +LT+EL++ ++    P   P  I+    LPKT +GKI R  LR
Sbjct: 508 QFLSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLR 558


>gi|42544134 SA hypertension-associated homolog isoform 2 [Homo
           sapiens]
          Length = 438

 Score =  104 bits (259), Expect = 3e-22
 Identities = 95/373 (25%), Positives = 158/373 (42%), Gaps = 54/373 (14%)

Query: 102 NICYNVLDRNVHEKKLGDKV---AFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQ-GI 157
           N   +VLD+   ++K G K    AF+W  N  GE  + ++ +L     +F+N+L +   +
Sbjct: 59  NFAKDVLDQWTDKEKAGKKPSNPAFWWI-NRNGEEMRWSFEELGSLSRKFANILSEACSL 117

Query: 158 QKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAF 217
           Q+GDRV + +P +PE  +A +AC R G +        + + +  R+  S  + +IT D  
Sbjct: 118 QRGDRVILILPRVPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKANCIITNDV- 176

Query: 218 YRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDV 277
                   L    D    KC+     +   ++V    R   G G+               
Sbjct: 177 --------LAPAVDAVASKCEN----LHSKLIVSENSRE--GWGNLK------------- 209

Query: 278 QISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYV 337
                        ELM+ A D          + + I +TSG++G PK   HT   + L +
Sbjct: 210 -------------ELMKHASDSHTCVKTKHNEIMAIFFTSGTSGYPKMTAHTHSSFGLGL 256

Query: 338 ATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSI 397
           +   ++  D    DV W T+D GW        + P   GA  V    +P +   + L ++
Sbjct: 257 SVNGRFWLDLTPSDVMWNTSDTGWAKSAWSSVFSPWIQGA-CVFTHHLPRFEPTSILQTL 315

Query: 398 VDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQ 457
             KY +T F +APT  R+L++     +T +   SL+   + GEPI P+    +    G  
Sbjct: 316 -SKYPITVFCSAPTVYRMLVQ---NDITSYKFKSLKHCVSAGEPITPDVTEKWRNKTGLD 371

Query: 458 RCPIVDTFWQTET 470
              I + + QTET
Sbjct: 372 ---IYEGYGQTET 381


>gi|187761345 acyl-CoA synthetase family member 3 [Homo sapiens]
          Length = 576

 Score =  103 bits (256), Expect = 7e-22
 Identities = 102/385 (26%), Positives = 168/385 (43%), Gaps = 44/385 (11%)

Query: 313 ILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGP 372
           I+YTSG+TG+PKGV+ T       V T   + + +  +DV      +  + G       P
Sbjct: 199 IIYTSGTTGRPKGVLSTHQNIRA-VVTGLVHKWAWTKDDVILHVLPLHHVHGVVNALLCP 257

Query: 373 LANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTK------ 426
           L  GAT V+           +  S  +  ++  F   PT    LM++ D   T+      
Sbjct: 258 LWVGATCVMMPEFSPQQVWEKFLSS-ETPRINVFMAVPTIYTKLMEYYDRHFTQPHAQDF 316

Query: 427 -----HSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGA 481
                  +  L V G+   P+ P    W + + G     +++ +  TE G  +  PL  A
Sbjct: 317 LRAVCEEKIRLMVSGSAALPL-PVLEKWKN-ITGHT---LLERYGMTEIGMALSGPLTTA 371

Query: 482 TPMKPGSATFPFFGVAPAILNESGEE--------LEGEAEGYLV---FKQP-------WP 523
             + PGS   P  GV   I++E+ +          EG+  G  V   F++         P
Sbjct: 372 VRL-PGSVGTPLPGVQVRIVSENPQREACSYTIHAEGDERGTKVTPGFEEKEGELLVRGP 430

Query: 524 GIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRID-DMLNVSGHLLSTA 582
            + R  +   E  ++ +     G++ TGD     +DG YWI GR   D++   G+ +S  
Sbjct: 431 SVFREYWNKPEETKSAF--TLDGWFKTGDTVVF-KDGQYWIRGRTSVDIIKTGGYKVSAL 487

Query: 583 EVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPI 642
           EVE  L+ H ++ + AV+G P    G+ +   VTL +GH+ S +   ELK+  R  + P 
Sbjct: 488 EVEWHLLAHPSITDVAVIGVPDMTWGQRVTAVVTLREGHSLSHR---ELKEWARNVLAPY 544

Query: 643 ATPDYIQNAPGLPKTRSGKIMRRVL 667
           A P  +     +P+ + GKI ++ L
Sbjct: 545 AVPSELVLVEEIPRNQMGKIDKKAL 569


>gi|187761343 acyl-CoA synthetase family member 3 [Homo sapiens]
          Length = 576

 Score =  103 bits (256), Expect = 7e-22
 Identities = 102/385 (26%), Positives = 168/385 (43%), Gaps = 44/385 (11%)

Query: 313 ILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGP 372
           I+YTSG+TG+PKGV+ T       V T   + + +  +DV      +  + G       P
Sbjct: 199 IIYTSGTTGRPKGVLSTHQNIRA-VVTGLVHKWAWTKDDVILHVLPLHHVHGVVNALLCP 257

Query: 373 LANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTK------ 426
           L  GAT V+           +  S  +  ++  F   PT    LM++ D   T+      
Sbjct: 258 LWVGATCVMMPEFSPQQVWEKFLSS-ETPRINVFMAVPTIYTKLMEYYDRHFTQPHAQDF 316

Query: 427 -----HSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGA 481
                  +  L V G+   P+ P    W + + G     +++ +  TE G  +  PL  A
Sbjct: 317 LRAVCEEKIRLMVSGSAALPL-PVLEKWKN-ITGHT---LLERYGMTEIGMALSGPLTTA 371

Query: 482 TPMKPGSATFPFFGVAPAILNESGEE--------LEGEAEGYLV---FKQP-------WP 523
             + PGS   P  GV   I++E+ +          EG+  G  V   F++         P
Sbjct: 372 VRL-PGSVGTPLPGVQVRIVSENPQREACSYTIHAEGDERGTKVTPGFEEKEGELLVRGP 430

Query: 524 GIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRID-DMLNVSGHLLSTA 582
            + R  +   E  ++ +     G++ TGD     +DG YWI GR   D++   G+ +S  
Sbjct: 431 SVFREYWNKPEETKSAF--TLDGWFKTGDTVVF-KDGQYWIRGRTSVDIIKTGGYKVSAL 487

Query: 583 EVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPI 642
           EVE  L+ H ++ + AV+G P    G+ +   VTL +GH+ S +   ELK+  R  + P 
Sbjct: 488 EVEWHLLAHPSITDVAVIGVPDMTWGQRVTAVVTLREGHSLSHR---ELKEWARNVLAPY 544

Query: 643 ATPDYIQNAPGLPKTRSGKIMRRVL 667
           A P  +     +P+ + GKI ++ L
Sbjct: 545 AVPSELVLVEEIPRNQMGKIDKKAL 569


>gi|195947378 acyl-coenzyme A synthetase ACSM6, mitochondrial [Homo
           sapiens]
          Length = 480

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 107/486 (22%), Positives = 194/486 (39%), Gaps = 63/486 (12%)

Query: 102 NICYNVLDRNVHEKKLGDKVAF--YWEGNEPGETTQITYHQLLVQVCQFSNVLRKQ-GIQ 158
           N   +VLD+    +K G +  +   W+ +  GE  + ++ ++     + +++L     + 
Sbjct: 50  NFAKDVLDQWSQLEKDGLRGPYPALWKVSAKGEEDKWSFERMTQLSKKAASILSDTCALS 109

Query: 159 KGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFY 218
            GDR+ I +P  PE     LAC R+G    I F   S +   ++I               
Sbjct: 110 HGDRLMIILPPTPEAYWICLACVRLG----ITFVPGSPQLTAKKI--------------- 150

Query: 219 RGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQ 278
                            + Q +    +C +  + +      +  + S  P +K       
Sbjct: 151 -----------------RYQLRMSKAQCIVANEAMAPV---VNSAVSDCPTLKTKLLVSD 190

Query: 279 ISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVA 338
            S++  +D  + +L+Q A  +       ++DP+ I +T G+TG PK V ++  G  +  +
Sbjct: 191 KSYDGWLD--FKKLIQVAPPKQTYMRTKSQDPMAIFFTKGTTGAPKMVEYSQYGLGMGFS 248

Query: 339 TTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIV 398
              +   D    DV W   D    +       G    GA   L   +PT+     L +++
Sbjct: 249 QASRRWMDLQPTDVLWSLGDAFGGSLSLSAVLGTWFQGACVFLCH-MPTFCPETVL-NVL 306

Query: 399 DKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQR 458
            ++ +T     P   + L++   +  T +   SL+     G PI+P     + R+    +
Sbjct: 307 SRFPITTLSANPEMYQELLQH--KCFTSYRFKSLKQCVAAGGPISPGVIEDWKRIT---K 361

Query: 459 CPIVDTFWQTETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVF 518
             I + + QTETG  +L        +KP S   P       I++E+   L    EG +  
Sbjct: 362 LDIYEGYGQTETG--LLCATSKTIKLKPSSLGKPLPPYIVQIVDENSNLLPPGEEGNIAI 419

Query: 519 K----QPWPGIMRTVYGNHE-RFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLN 573
           +    QP      ++Y  H   +E     +    Y+TGD    D+DGY+W +GR+DD+ N
Sbjct: 420 RIKLNQP-----ASLYCPHMVSWEEYASARGHMLYLTGDRGIMDEDGYFWWSGRVDDVAN 474

Query: 574 VSGHLL 579
             G  L
Sbjct: 475 ALGQRL 480


>gi|40807357 solute carrier family 27 (fatty acid transporter),
           member 4 [Homo sapiens]
          Length = 643

 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 122/571 (21%), Positives = 202/571 (35%), Gaps = 76/571 (13%)

Query: 119 DKVAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAML 178
           DK A  +EG +    T  T+ QL       +N L+ +G+  GD  AI+M    E V   L
Sbjct: 89  DKTALIFEGTD----THWTFRQLDEYSSSVANFLQARGLASGDVAAIFMENRNEFVGLWL 144

Query: 179 ACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQK-C 237
             A++G   +++      ++L   +  S    L+          +  +    D +L   C
Sbjct: 145 GMAKLGVEAALINTNLRRDALLHCLTTSRARALVFGSEM--ASAICEVHASLDPSLSLFC 202

Query: 238 QEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAG 297
                P       +HL      + D+    P    SCPD   +                 
Sbjct: 203 SGSWEPGAVPPSTEHLDPL---LKDAPKHLP----SCPDKGFT----------------- 238

Query: 298 DECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTA 357
                      D LF +YTSG+TG PK  +     Y    A  + Y F     D+ +   
Sbjct: 239 -----------DKLFYIYTSGTTGLPKAAIVVHSRYYRMAALVY-YGFRMRPNDIVYDCL 286

Query: 358 DIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLM 417
            +    G+       L +G T V+ +        +R W    KY  T         R L+
Sbjct: 287 PLYHSAGNIVGIGQCLLHGMTVVIRKKF----SASRFWDDCIKYNCTIVQYIGELCRYLL 342

Query: 418 KFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYH---------RVVGAQRCPIVDTFWQT 468
              ++P  + +    QV   +G  +    W  +             GA  C      + +
Sbjct: 343 ---NQP-PREAENQHQVRMALGNGLRQSIWTNFSSRFHIPQVAEFYGATECNCSLGNFDS 398

Query: 469 ETGG-----HMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQP-- 521
           + G       +L+ +     ++    T         +         G+  G ++ K P  
Sbjct: 399 QVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGEPGQLVGRIIQKDPLR 458

Query: 522 -WPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLS 580
            + G +     N+++     FKK    Y+TGD    D+ GY +   R  D     G  +S
Sbjct: 459 RFDGYLNQG-ANNKKIAKDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVS 517

Query: 581 TAEVESALVEHEAVAEAAVVGHPHP-VKGECLYCFVTLCDGHTFSPKLTEELKKQIREKI 639
           T EVE  L     +A+ AV G   P  +G      V    G+    +  + L+K++    
Sbjct: 518 TTEVEGTLSRLLDMADVAVYGVEVPGTEGRAGMAAVASPTGNCDLERFAQVLEKEL---- 573

Query: 640 GPI-ATPDYIQNAPGLPKTRSGKIMRRVLRK 669
            P+ A P +++  P L KT + K  +  LRK
Sbjct: 574 -PLYARPIFLRLLPELHKTGTYKFQKTELRK 603


>gi|38524616 solute carrier family 27, member 1 [Homo sapiens]
          Length = 646

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 127/570 (22%), Positives = 212/570 (37%), Gaps = 105/570 (18%)

Query: 137 TYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSS 196
           T+ QL       +N+ R+ G   GD VAI++   PE V   L  A+ G   +++      
Sbjct: 105 TFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRR 164

Query: 197 ESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRA 256
           E L   +  S    LI     + GE +  + E++                     HLG++
Sbjct: 165 EPLAFCLGTSGAKALI-----FGGEMVAAVAEVSG--------------------HLGKS 199

Query: 257 -------ELG----MGDSTSQSPPIKRS--CPDVQISWNQGIDLWWHELMQEAGDECEPE 303
                  +LG    + D+    P +K +   P  QI  ++G+D                 
Sbjct: 200 LIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIP-SKGMD----------------- 241

Query: 304 WCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWIT 363
                D LF +YTSG+TG PK  +     Y   +A    + +   A DV +    +    
Sbjct: 242 -----DRLFYIYTSGTTGLPKAAIVVHSRYYR-MAAFGHHAYRMQAADVLYDCLPLYHSA 295

Query: 364 GHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEP 423
           G+       L  G T VL +        +R W    KY  T         R L+K   +P
Sbjct: 296 GNIIGVGQCLIYGLTVVLRKKF----SASRFWDDCIKYNCTVVQYIGEICRYLLK---QP 348

Query: 424 VTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGATP 483
           V +  R   +V   VG  + P  W  +    G ++   +  F+        +  + G   
Sbjct: 349 VREAERRH-RVRLAVGNGLRPAIWEEFTERFGVRQ---IGEFYGATECNCSIANMDG--- 401

Query: 484 MKPGSATFP------FFGVAPAILNESGEELEGEAEGYLVFKQPW-PGIMRTVYGNHE-- 534
            K GS  F        + +    +NE   EL  +A+G  +  Q   PG++       +  
Sbjct: 402 -KVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPL 460

Query: 535 -RFET-------------TYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLS 580
            RF+              + F K    Y++GD    D+ GY +   R  D     G  +S
Sbjct: 461 RRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVS 520

Query: 581 TAEVESALVEHEAVAEAAVVGHPHP-VKGECLYCFVTLCDGHTFSPKLTEELKKQIREKI 639
           T EVE  L       + AV G   P V+G+       + D H+        + +++++ +
Sbjct: 521 TTEVEGVLSRLLGQTDVAVYGVAVPGVEGKA--GMAAVADPHSLLD--PNAIYQELQKVL 576

Query: 640 GPIATPDYIQNAPGLPKTRSGKIMRRVLRK 669
            P A P +++  P +  T + KI +  L++
Sbjct: 577 APYARPIFLRLLPQVDTTGTFKIQKTRLQR 606


>gi|156151445 acyl-CoA synthetase family member 2 [Homo sapiens]
          Length = 615

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 41/123 (33%), Positives = 55/123 (44%), Gaps = 3/123 (2%)

Query: 547 YYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPV 606
           +Y TGD    ++ G+  I GR  DM+   G  +  AE+E     H  V E  VVG     
Sbjct: 488 WYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDR 547

Query: 607 KGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRV 666
            GE +   + L DG   +    EE+K   + KI     P YI      P T SGKI +  
Sbjct: 548 MGEEICACIRLKDGEETT---VEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFK 604

Query: 667 LRK 669
           LR+
Sbjct: 605 LRE 607


>gi|13325057 solute carrier family 27 (fatty acid transporter),
           member 5 [Homo sapiens]
          Length = 690

 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 86/380 (22%), Positives = 143/380 (37%), Gaps = 37/380 (9%)

Query: 310 PLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVT 369
           P   +YTSG+TG PK  + T     +   +    +    A+DV +    +  + G     
Sbjct: 289 PALFIYTSGTTGLPKPAILT--HERVLQMSKMLSLSGATADDVVYTVLPLYHVMGLVVGI 346

Query: 370 YGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSR 429
            G L  GAT VL     T    +  W    ++ VT        +R L     +P  +   
Sbjct: 347 LGCLDLGATCVLAPKFST----SCFWDDCRQHGVTVILYVGELLRYLCNIPQQPEDRTHT 402

Query: 430 ASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETG-------------GHMLT 476
             L     +G  +  + W  + +  G  R  I + +  TE               G M  
Sbjct: 403 VRL----AMGNGLRADVWETFQQRFGPIR--IWEVYGSTEGNMGLVNYVGRCGALGKMSC 456

Query: 477 PLPGATPMKPGSATFPFFGVAPAILNES-----GEELEGEAEGYLVFKQPWPGIMRTVYG 531
            L   +P +     F      P   N+      G    G     +V +QP+ G       
Sbjct: 457 LLRMLSPFE--LVQFDMEAAEPVRDNQGFCIPVGLGEPGLLLTKVVSQQPFVGYRGPREL 514

Query: 532 NHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEH 591
           +  +      +    YY TGD    D++G+ +   R+ D     G  +ST EVE  L + 
Sbjct: 515 SERKLVRNVRQSGDVYYNTGDVLAMDREGFLYFRDRLGDTFRWKGENVSTHEVEGVLSQV 574

Query: 592 EAVAEAAVVGHPHP-VKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQN 650
           + + +  V G   P  +G+     V L  G TF     E+L + +R  +   ATP +I+ 
Sbjct: 575 DFLQQVNVYGVCVPGCEGKVGMAAVQLAPGQTFD---GEKLYQHVRAWLPAYATPHFIRI 631

Query: 651 APGLPKTRSGKIMR-RVLRK 669
              +  T + K+M+ R++R+
Sbjct: 632 QDAMEVTSTFKLMKTRLVRE 651


>gi|13236579 solute carrier family 27 member 3 [Homo sapiens]
          Length = 730

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 85/404 (21%), Positives = 150/404 (37%), Gaps = 38/404 (9%)

Query: 309 DPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYV 368
           D    ++TSG+TG PK     +    +     F  +   H EDV +    +  ++G    
Sbjct: 328 DTCLYIFTSGTTGLPKAA--RISHLKILQCQGFYQLCGVHQEDVIYLALPLYHMSGSLLG 385

Query: 369 TYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHS 428
             G +  GAT VL           + W    +++VT F       R L+   ++P +K  
Sbjct: 386 IVGCMGIGATVVLKSKF----SAGQFWEDCQQHRVTVFQYIGELCRYLV---NQPPSKAE 438

Query: 429 RASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGATPMKPGS 488
           R   +V   VG  + P+ W  + R  G  +  +++T+  TE  G++ T          G 
Sbjct: 439 RGH-KVRLAVGSGLRPDTWERFVRRFGPLQ--VLETYGLTE--GNVATINYTGQRGAVGR 493

Query: 489 ATFPFFGVAPAILNE----SGEELEGEAEGYLVFKQPW-PGIMRTVYGNHERF------- 536
           A++ +  + P  L      +GE +  + +G+ +   P  PG++         F       
Sbjct: 494 ASWLYKHIFPFSLIRYDVTTGEPIR-DPQGHCMATSPGEPGLLVAPVSQQSPFLGYAGGP 552

Query: 537 -------ETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALV 589
                      F+    ++ TGD    D  G+     R  D     G  ++T EV     
Sbjct: 553 ELAQGKLLKDVFRPGDVFFNTGDLLVCDDQGFLRFHDRTGDTFRWKGENVATTEVAEVFE 612

Query: 590 EHEAVAEAAVVGHPHP-VKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYI 648
             + + E  V G   P  +G      + L   H        +L   + E + P A P ++
Sbjct: 613 ALDFLQEVNVYGVTVPGHEGRAGMAALVLRPPHALD---LMQLYTHVSENLPPYARPRFL 669

Query: 649 QNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDMSTVADPSVISHL 692
           +    L  T + K  +  +     +   L D   V D +V ++L
Sbjct: 670 RLQESLATTETFKQQKVRMANEGFDPSTLSDPLYVLDQAVGAYL 713


>gi|62865631 solute carrier family 27 (fatty acid transporter),
           member 6 [Homo sapiens]
          Length = 619

 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 111/517 (21%), Positives = 184/517 (35%), Gaps = 81/517 (15%)

Query: 107 VLDRNV-HEKKLGDKVAFYWEGNEPGETTQITYHQLLVQVCQFSNV-LRKQGIQKGDRVA 164
           VLD+ + H K+   K    +EG+        TY  +  +  + ++V L    ++KGD VA
Sbjct: 56  VLDKFLSHAKRQPRKPFIIYEGDI------YTYQDVDKRSSRVAHVFLNHSSLKKGDTVA 109

Query: 165 IYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSC---SLLITTDAFYRGE 221
           + M   P+ V      A++G + + +     S SL   I   +C   +L++  D     E
Sbjct: 110 LLMSNEPDFVHVWFGLAKLGCVVAFLNTNIRSNSLLNCI--RACGPRALVVGADLLGTVE 167

Query: 222 KLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISW 281
           ++  L  L++       +   P     + + L         STS   P+ RS        
Sbjct: 168 EI--LPSLSENISVWGMKDSVPQGVISLKEKL---------STSPDEPVPRS-------- 208

Query: 282 NQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTF 341
                   H ++      C             ++TSG+TG PK  V  +    +   +  
Sbjct: 209 --------HHVVSLLKSTC-----------LYIFTSGTTGLPKAAV--ISQLQVLRGSAV 247

Query: 342 KYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKY 401
            + F   A D+ + T  +   +       G +  GAT VL +        ++ WS   KY
Sbjct: 248 LWAFGCTAHDIVYITLPLYHSSAAILGISGCVELGATCVLKKKF----SASQFWSDCKKY 303

Query: 402 KVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPI 461
            VT F       R L K       K  +  L     +G  I  + W  +    G     +
Sbjct: 304 DVTVFQYIGELCRYLCKQSKREGEKDHKVRL----AIGNGIRSDVWREFLDRFG--NIKV 357

Query: 462 VDTFWQTETGGHMLT------PLPGATPMKPGSATFPF----FGVAPAILNESG---EEL 508
            + +  TE+    +        +          +TF      F     + NE G      
Sbjct: 358 CELYAATESSISFMNYTGRIGAIGRTNLFYKLLSTFDLIKYDFQKDEPMRNEQGWCIHVK 417

Query: 509 EGEAEGYLV----FKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWI 564
           +GE  G L+     K P+ G         ++     FKK   Y  TGD   +DQD + + 
Sbjct: 418 KGE-PGLLISRVNAKNPFFGYAGPYKHTKDKLLCDVFKKGDVYLNTGDLIVQDQDNFLYF 476

Query: 565 TGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVG 601
             R  D     G  ++T EV   +   + + EA V G
Sbjct: 477 WDRTGDTFRWKGENVATTEVADVIGMLDFIQEANVYG 513


>gi|13325055 solute carrier family 27 (fatty acid transporter),
           member 6 [Homo sapiens]
          Length = 619

 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 111/517 (21%), Positives = 184/517 (35%), Gaps = 81/517 (15%)

Query: 107 VLDRNV-HEKKLGDKVAFYWEGNEPGETTQITYHQLLVQVCQFSNV-LRKQGIQKGDRVA 164
           VLD+ + H K+   K    +EG+        TY  +  +  + ++V L    ++KGD VA
Sbjct: 56  VLDKFLSHAKRQPRKPFIIYEGDI------YTYQDVDKRSSRVAHVFLNHSSLKKGDTVA 109

Query: 165 IYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSC---SLLITTDAFYRGE 221
           + M   P+ V      A++G + + +     S SL   I   +C   +L++  D     E
Sbjct: 110 LLMSNEPDFVHVWFGLAKLGCVVAFLNTNIRSNSLLNCI--RACGPRALVVGADLLGTVE 167

Query: 222 KLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISW 281
           ++  L  L++       +   P     + + L         STS   P+ RS        
Sbjct: 168 EI--LPSLSENISVWGMKDSVPQGVISLKEKL---------STSPDEPVPRS-------- 208

Query: 282 NQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTF 341
                   H ++      C             ++TSG+TG PK  V  +    +   +  
Sbjct: 209 --------HHVVSLLKSTC-----------LYIFTSGTTGLPKAAV--ISQLQVLRGSAV 247

Query: 342 KYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKY 401
            + F   A D+ + T  +   +       G +  GAT VL +        ++ WS   KY
Sbjct: 248 LWAFGCTAHDIVYITLPLYHSSAAILGISGCVELGATCVLKKKF----SASQFWSDCKKY 303

Query: 402 KVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPI 461
            VT F       R L K       K  +  L     +G  I  + W  +    G     +
Sbjct: 304 DVTVFQYIGELCRYLCKQSKREGEKDHKVRL----AIGNGIRSDVWREFLDRFG--NIKV 357

Query: 462 VDTFWQTETGGHMLT------PLPGATPMKPGSATFPF----FGVAPAILNESG---EEL 508
            + +  TE+    +        +          +TF      F     + NE G      
Sbjct: 358 CELYAATESSISFMNYTGRIGAIGRTNLFYKLLSTFDLIKYDFQKDEPMRNEQGWCIHVK 417

Query: 509 EGEAEGYLV----FKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWI 564
           +GE  G L+     K P+ G         ++     FKK   Y  TGD   +DQD + + 
Sbjct: 418 KGE-PGLLISRVNAKNPFFGYAGPYKHTKDKLLCDVFKKGDVYLNTGDLIVQDQDNFLYF 476

Query: 565 TGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVG 601
             R  D     G  ++T EV   +   + + EA V G
Sbjct: 477 WDRTGDTFRWKGENVATTEVADVIGMLDFIQEANVYG 513


>gi|45580730 aminoadipate-semialdehyde dehydrogenase [Homo sapiens]
          Length = 1098

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 89/376 (23%), Positives = 153/376 (40%), Gaps = 44/376 (11%)

Query: 312 FILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYG 371
           ++L+TSG+TG PK +V      ++     F+ +FD   EDV +  + + +      + + 
Sbjct: 194 YVLHTSGTTGIPK-IVRVPHKCIVPNIQHFRVLFDITQEDVLFLASPLTFDPSVVEI-FL 251

Query: 372 PLANGATSVLFEGIPTYPDV--NRLWSIV-DKYKVTKFYTAPTAIRLLMKFGDEPVTK-- 426
            L++GA+ ++   +PT   +  ++L S++   ++VT     PT   LL +FG + +    
Sbjct: 252 ALSSGASLLI---VPTSVKLLPSKLASVLFSHHRVTVLQATPT---LLRRFGSQLIKSTV 305

Query: 427 -HSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHM-LTPLPGATPM 484
             +  SL+VL   GE       L   R  G  +  I + +  TE      +  +P  T  
Sbjct: 306 LSATTSLRVLALGGEAFPSLTVLRSWRGEG-NKTQIFNVYGITEVSSWATIYRIPEKTLN 364

Query: 485 K------PGSATFPFFGVAPAILNESGEEL-EGEAEGYLVFKQPWPGIMRTVYGNHERFE 537
                  P    FP  G    + + +G  + EG  + +L       G  R  + + E   
Sbjct: 365 STLKCELPVQLGFPLLGTVVEVRDTNGFTIQEGSGQVFL------GGRNRVCFLDDEVTV 418

Query: 538 TTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEA 597
                +  G +VT       +DG  +  GR D  +   G  L+   V+    E + V   
Sbjct: 419 PLGTMRATGDFVTV------KDGEIFFLGRKDSQIKRHGKRLNIELVQQVAEELQQVESC 472

Query: 598 AVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKT 657
           AV  +      E L  F+   D       + E + K++++ +   A PD +     LP T
Sbjct: 473 AVTWYNQ----EKLILFMVSKDA-----SVKEYIFKELQKYLPSHAVPDELVLIDSLPFT 523

Query: 658 RSGKIMRRVLRKIAQN 673
             GKI    L KI  N
Sbjct: 524 SHGKIDVSELNKIYLN 539


>gi|227499619 solute carrier family 27 (fatty acid transporter),
           member 2 isoform 1 [Homo sapiens]
          Length = 620

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 75/358 (20%), Positives = 131/358 (36%), Gaps = 34/358 (9%)

Query: 310 PLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVT 369
           P   +YTSG+TG PK  + T     ++  T   +V    A+DV + T             
Sbjct: 219 PALYIYTSGTTGLPKAAMIT--HQRIWYGTGLTFVSGLKADDVIYITLPFYHSAALLIGI 276

Query: 370 YGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSR 429
           +G +  GAT  L     T    ++ W    KY VT        +R L     +P  +  +
Sbjct: 277 HGCIVAGATLAL----RTKFSASQFWDDCRKYNVTVIQYIGELLRYLCNSPQKPNDRDHK 332

Query: 430 ASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETG------GHMLTPLPGATP 483
             L     +G  +  + W  + +  G   C I + +  TE           +  +     
Sbjct: 333 VRL----ALGNGLRGDVWRQFVKRFG-DIC-IYEFYAATEGNIGFMNYARKVGAVGRVNY 386

Query: 484 MKPGSATFPFFGV----APAILNESG---EELEGEAEGYLVFK----QPWPGIMRTVYGN 532
           ++    T+            + +E+G      +GE  G LV K     P+ G        
Sbjct: 387 LQKKIITYDLIKYDVEKDEPVRDENGYCVRVPKGEV-GLLVCKITQLTPFNGYAGAKAQT 445

Query: 533 HERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHE 592
            ++     FKK   Y+ +GD    D + + +   R+ D     G  ++T EV   +   +
Sbjct: 446 EKKKLRDVFKKGDLYFNSGDLLMVDHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVD 505

Query: 593 AVAEAAVVG-HPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQ 649
            V E  V G H    +G      + + + H F  K   +L + I + +   A P +++
Sbjct: 506 FVQEVNVYGVHVPDHEGRIGMASIKMKENHEFDGK---KLFQHIADYLPSYARPRFLR 560


>gi|4758332 acyl-CoA synthetase long-chain family member 4 isoform 1
           [Homo sapiens]
          Length = 670

 Score = 38.5 bits (88), Expect = 0.021
 Identities = 41/207 (19%), Positives = 78/207 (37%), Gaps = 48/207 (23%)

Query: 131 GETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACARIGALHSIV 190
           G    + Y ++  +V  F + L   G++  + +AI+     E ++A   C +       +
Sbjct: 80  GNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTL 139

Query: 191 FAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELA---------DEALQKCQ-EK 240
           +A    E++   + +S  S LIT+      +    L +++         ++A+ K +  +
Sbjct: 140 YATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPE 199

Query: 241 GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDEC 300
           GF +     V+ LG     +G   S+  P                               
Sbjct: 200 GFEIHSMQSVEELGSNPENLGIPPSRPTP------------------------------- 228

Query: 301 EPEWCDAEDPLFILYTSGSTGKPKGVV 327
                   D   ++YTSGSTG+PKGV+
Sbjct: 229 -------SDMAIVMYTSGSTGRPKGVM 248


>gi|12669909 acyl-CoA synthetase long-chain family member 4 isoform
           2 [Homo sapiens]
          Length = 711

 Score = 38.5 bits (88), Expect = 0.021
 Identities = 41/207 (19%), Positives = 78/207 (37%), Gaps = 48/207 (23%)

Query: 131 GETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACARIGALHSIV 190
           G    + Y ++  +V  F + L   G++  + +AI+     E ++A   C +       +
Sbjct: 121 GNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTL 180

Query: 191 FAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELA---------DEALQKCQ-EK 240
           +A    E++   + +S  S LIT+      +    L +++         ++A+ K +  +
Sbjct: 181 YATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPE 240

Query: 241 GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDEC 300
           GF +     V+ LG     +G   S+  P                               
Sbjct: 241 GFEIHSMQSVEELGSNPENLGIPPSRPTP------------------------------- 269

Query: 301 EPEWCDAEDPLFILYTSGSTGKPKGVV 327
                   D   ++YTSGSTG+PKGV+
Sbjct: 270 -------SDMAIVMYTSGSTGRPKGVM 289


>gi|27477105 lipidosin [Homo sapiens]
          Length = 724

 Score = 36.2 bits (82), Expect = 0.11
 Identities = 49/220 (22%), Positives = 90/220 (40%), Gaps = 49/220 (22%)

Query: 116 KLGDKVAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVV 175
           K GD +A  ++  +  E   I+Y Q  +   + +    K G+++   VAI     PE   
Sbjct: 115 KYGDLIALGFKRQDKWE--HISYSQYYLLARRAAKGFLKLGLKQAHSVAILGFNSPEWFF 172

Query: 176 AMLACARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNL-KELADEAL 234
           + +     G + + ++   S E+ C+ I    C+ +I  D   + EK++ + K+L     
Sbjct: 173 SAVGTVFAGGIVTGIYTTSSPEA-CQYIAYDCCANVIMVDTQKQLEKILKIWKQLPH--- 228

Query: 235 QKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQ 294
                    ++  ++ K              + PP            N+  +++  E   
Sbjct: 229 ---------LKAVVIYK--------------EPPP------------NKMANVYTMEEFM 253

Query: 295 EAGDECEPEWCDA----EDP---LFILYTSGSTGKPKGVV 327
           E G+E   E  DA    + P     ++YTSG+TG PKGV+
Sbjct: 254 ELGNEVPEEALDAIIDTQQPNQCCVLVYTSGTTGNPKGVM 293



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 17/58 (29%), Positives = 33/58 (56%), Gaps = 2/58 (3%)

Query: 546 GYYVTGDGCQRDQDGYYWITGRIDDM-LNVSGHLLSTAEVESAL-VEHEAVAEAAVVG 601
           G+  TGD  + D DG+ +ITGR+ ++ +   G  +    +E A+ +E   ++ A ++G
Sbjct: 544 GWLHTGDAGRLDADGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISNAMLIG 601


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.440 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,316,087
Number of Sequences: 37866
Number of extensions: 1476179
Number of successful extensions: 3817
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 3694
Number of HSP's gapped (non-prelim): 75
length of query: 701
length of database: 18,247,518
effective HSP length: 109
effective length of query: 592
effective length of database: 14,120,124
effective search space: 8359113408
effective search space used: 8359113408
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.