Search of human proteins with 14150035

Search of human proteins with 14150035

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo
sapiens]
         (771 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]   1550   0.0  
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]      628   e-180
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6...   625   e-179
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ...   598   e-171
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]    432   e-121
gi|4758968 cytohesin 3 [Homo sapiens]                                 112   1e-24
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]                     112   2e-24
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]                       112   2e-24
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]                     107   3e-23
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]                       107   3e-23
gi|7019505 cytohesin 4 [Homo sapiens]                                  99   2e-20
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti...    99   2e-20
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr...    92   1e-18
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]                  91   4e-18
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]       90   9e-18
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]        90   9e-18
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]        88   3e-17
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]        88   3e-17
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange...    85   3e-16
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [...    60   1e-08
gi|48928044 F-box only protein 8 [Homo sapiens]                        57   5e-08
gi|67782321 spectrin beta isoform a [Homo sapiens]                     57   8e-08
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]           55   2e-07
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]           55   3e-07
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]           54   4e-07
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ...    49   2e-05
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ...    46   1e-04
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap...    44   4e-04
gi|154146216 pleckstrin homology domain containing, family A (ph...    41   0.005
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]                38   0.031

>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
          Length = 771

 Score = 1550 bits (4014), Expect = 0.0
 Identities = 771/771 (100%), Positives = 771/771 (100%)

Query: 1   MEEDKLLSAVPEEGDATRDPGPEPEEEPGVRNGMASEGLNSSLCSPGHERRGTPADTEEP 60
           MEEDKLLSAVPEEGDATRDPGPEPEEEPGVRNGMASEGLNSSLCSPGHERRGTPADTEEP
Sbjct: 1   MEEDKLLSAVPEEGDATRDPGPEPEEEPGVRNGMASEGLNSSLCSPGHERRGTPADTEEP 60

Query: 61  TKDPDVAFHGLSLGLSLTNGLALGPDLNILEDSAESRPWRAGVLAEGDNASRSLYPDAED 120
           TKDPDVAFHGLSLGLSLTNGLALGPDLNILEDSAESRPWRAGVLAEGDNASRSLYPDAED
Sbjct: 61  TKDPDVAFHGLSLGLSLTNGLALGPDLNILEDSAESRPWRAGVLAEGDNASRSLYPDAED 120

Query: 121 PQLGLDGPGEPDVRDGFSATFEKILESELLRGTQYSSLDSLDGLSLTDESDSCVSFEAPL 180
           PQLGLDGPGEPDVRDGFSATFEKILESELLRGTQYSSLDSLDGLSLTDESDSCVSFEAPL
Sbjct: 121 PQLGLDGPGEPDVRDGFSATFEKILESELLRGTQYSSLDSLDGLSLTDESDSCVSFEAPL 180

Query: 181 TPLIQQRARDSPEPGAGLGIGDMAFEGDMGAAGGDGELGSPLRRSISSSRSENVLSRLSL 240
           TPLIQQRARDSPEPGAGLGIGDMAFEGDMGAAGGDGELGSPLRRSISSSRSENVLSRLSL
Sbjct: 181 TPLIQQRARDSPEPGAGLGIGDMAFEGDMGAAGGDGELGSPLRRSISSSRSENVLSRLSL 240

Query: 241 MAMPNGFHEDGPQGPGGDEDDDEEDTDKLLNSASDPSLKDGLSDSDSELSSSEGLEPGSA 300
           MAMPNGFHEDGPQGPGGDEDDDEEDTDKLLNSASDPSLKDGLSDSDSELSSSEGLEPGSA
Sbjct: 241 MAMPNGFHEDGPQGPGGDEDDDEEDTDKLLNSASDPSLKDGLSDSDSELSSSEGLEPGSA 300

Query: 301 DPLANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLT 360
           DPLANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLT
Sbjct: 301 DPLANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLT 360

Query: 361 LDGALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDL 420
           LDGALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDL
Sbjct: 361 LDGALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDL 420

Query: 421 HGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSEL 480
           HGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSEL
Sbjct: 421 HGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSEL 480

Query: 481 VDDKFGTGTKKVTRILDGGNPFLDVPQALSATTYKHGVLTRKTHADMDGKRTPRGRRGWK 540
           VDDKFGTGTKKVTRILDGGNPFLDVPQALSATTYKHGVLTRKTHADMDGKRTPRGRRGWK
Sbjct: 481 VDDKFGTGTKKVTRILDGGNPFLDVPQALSATTYKHGVLTRKTHADMDGKRTPRGRRGWK 540

Query: 541 KFYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATRASDYSKKSNVLKLKTADW 600
           KFYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATRASDYSKKSNVLKLKTADW
Sbjct: 541 KFYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATRASDYSKKSNVLKLKTADW 600

Query: 601 RVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRLCQEEQL 660
           RVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRLCQEEQL
Sbjct: 601 RVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRLCQEEQL 660

Query: 661 RSHENKLRQLTAELAEHRCHPVERGIKSKEAEEYRLKEHYLTFEKSRYETYIHLLAMKIK 720
           RSHENKLRQLTAELAEHRCHPVERGIKSKEAEEYRLKEHYLTFEKSRYETYIHLLAMKIK
Sbjct: 661 RSHENKLRQLTAELAEHRCHPVERGIKSKEAEEYRLKEHYLTFEKSRYETYIHLLAMKIK 720

Query: 721 VGSDDLERIEARLATLEGDDPSLRKTHSSPALSQGHVTGSKTTKDATGPDT 771
           VGSDDLERIEARLATLEGDDPSLRKTHSSPALSQGHVTGSKTTKDATGPDT
Sbjct: 721 VGSDDLERIEARLATLEGDDPSLRKTHSSPALSQGHVTGSKTTKDATGPDT 771


>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
          Length = 1024

 Score =  628 bits (1619), Expect = e-180
 Identities = 348/634 (54%), Positives = 425/634 (67%), Gaps = 41/634 (6%)

Query: 126 DGPGEPDVRDGFSATFEKILESELLRGTQYSSLDSLDGLSLTDESDS-CVSFEAPLTPLI 184
           DGP      D FS  FE ILES   +GT Y+SL SL+ L+    + S   +FE P  P  
Sbjct: 397 DGP------DSFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPA 450

Query: 185 QQRARDSPEPGAGLGIGDMAFEGDMG-AAGGDGELGSPLRRSISSSRSENVLSRLSLMAM 243
            +    +P P A L       E D G ++  DG          + +R++    R      
Sbjct: 451 PRPDPPAPAPLAPL-------EPDSGTSSAADGPWTQRGEEEEAEARAKLAPGR----EP 499

Query: 244 PNGFHEDGPQGPGGDEDDDEEDTDKLLNSASDPSLKDGLSDSDSELSSSEGLEPGSADPL 303
           P+  H +   G G                 S+P L   +SDSDSEL S+E L  GS D L
Sbjct: 500 PSPCHSEDSLGLGAAP------------LGSEPPLSQLVSDSDSELDSTERLALGSTDTL 547

Query: 304 ANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDG 363
           +NG +   EAA RLA+RLY L+GF++ DVAR LGKNN+FS+LVAGEYL FF F+G+TLD 
Sbjct: 548 SNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQ 607

Query: 364 ALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGH 423
           ALR FLK   LMGETQERERVL HFS+RY QCNP+  +SEDG HTLTCALMLLNTDLHGH
Sbjct: 608 ALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGH 667

Query: 424 NIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDD 483
           NIGK+M+C  FI NL+ LNDG DF ++LLK LY+SIKNEKL+WAIDE+ELR+SLSEL D 
Sbjct: 668 NIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADP 727

Query: 484 KFGTGTKKVTRILDGGN-----PFLDVPQALSATTYKHGVLTRKTHADMDGKRTPRGRRG 538
                  KV + + GG+     PFLD+     A  YKHG L RK HAD D ++TPRG+RG
Sbjct: 728 N-----PKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGKRG 782

Query: 539 WKKFYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATRASDYSKKSNVLKLKTA 598
           WK F+ +LKG ILYLQK+EY+P KALSE +LKNAI +HHALATRASDYSK+ +V  L+TA
Sbjct: 783 WKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLRTA 842

Query: 599 DWRVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRLCQEE 658
           DWRVFLFQAPS E+M SWI RIN+VAA+FSAP FPAAVSS KKF RPLLPS  TRL QEE
Sbjct: 843 DWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEE 902

Query: 659 QLRSHENKLRQLTAELAEHRCHPVERGIKSKEAEEYRLKEHYLTFEKSRYETYIHLLAMK 718
           Q+R+HE KL+ + +EL EHR   + +  + KEAEE R KE YL FEKSRY TY  LL +K
Sbjct: 903 QVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLRVK 962

Query: 719 IKVGSDDLERIEARLATLEGDDPSLRKTHSSPAL 752
           +K GS++L+ +EA LA     +  L  +HSSP+L
Sbjct: 963 LKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSL 996


>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
            isoform a [Homo sapiens]
          Length = 1047

 Score =  625 bits (1612), Expect = e-179
 Identities = 339/629 (53%), Positives = 434/629 (68%), Gaps = 45/629 (7%)

Query: 127  GPG-EPDVRDGFSATFEKILESELLRGTQYSSLDSLDGLSLTDESDSCVSFEAPLTPLIQ 185
            GPG   D  D +S+ FE IL++  L    Y S +SL+  +L  E DS  SFE PLTP+IQ
Sbjct: 430  GPGYTEDSTDVYSSQFETILDNTSL----YYSAESLE--TLYSEPDSYFSFEMPLTPMIQ 483

Query: 186  QRARDSPEPGAGLGIGDMAFEGDMGAAGGDGELGSPLRRSISSSRSENVLSRLSLMAMPN 245
            QR ++          G    E   G  GG  ++       +S S    ++   S   + N
Sbjct: 484  QRIKE----------GGQFLERTSG--GGHQDI-------LSVSADGGIVMGYS-SGVTN 523

Query: 246  GFHEDGPQGPGGDEDDDEEDTDKLLNSASDPSLKDGLSDSDSELSSSEGLEPGSADPLAN 305
            G ++         +    + T ++    S+  +K    ++ SE+ S+E LE  + + L+N
Sbjct: 524  GLND-------ASDSIYTKGTPEIAFWGSNAGVKTTRLEAHSEMGSTEILEKETPENLSN 576

Query: 306  GCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGAL 365
            G     EAA RLA+RLY L+ F+R DVA+ LGKNNEFS+LVA EYL FFDF+G+TLD +L
Sbjct: 577  GTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSL 636

Query: 366  RTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNI 425
            R F KAF L+GETQERERVL HFS RY  CNPD   S+DG+H LTCA+MLLNTDLHGHNI
Sbjct: 637  RYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNI 696

Query: 426  GKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDDKF 485
            GKKM+CQ+FIANL  +N+G DF+KDLLK LYNSIKNEKLEWA+D++E +KS SE  ++K 
Sbjct: 697  GKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKA 756

Query: 486  -GTGTKKVTRILDGGNPFLDVPQALSATTYKHGVLTRKTHADMDGKRTPRGRRGWKKFYA 544
             GT  K ++RI    NPFLD+P   +A  YK G L RK HADMDGK+TPRG+RGWK FYA
Sbjct: 757  NGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYA 816

Query: 545  VLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATRASDYSKKSNVLKLKTADWRVFL 604
            VLKGT+LYLQKDEY+P+KALSE DLKNA+ VHHALA++A+DY KK NV KLKTADWRV L
Sbjct: 817  VLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLL 876

Query: 605  FQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRLCQEEQLRSHE 664
            FQ  S EEM  WI +IN VAA+FSAP FPAA+ S KKF RPLLP+ TT+L QEEQL+SHE
Sbjct: 877  FQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHE 936

Query: 665  NKLRQLTAELAEHRCHPVERGIKSKEAEEYRLKEHYLTFEKSRYETYIHLLAMKIKVGSD 724
            +KL+Q+T ELAEHR +P ++ +K+K+ +EY+LK+HYL FEK+RYE Y+ +L    K G  
Sbjct: 937  SKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSIL----KEGGK 992

Query: 725  DLERIEARLATLEGDDPSLRKTHSSPALS 753
            +L      L+  E +   L+K+HSSP+L+
Sbjct: 993  EL------LSNDESEAAGLKKSHSSPSLN 1015


>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
           isoform b [Homo sapiens]
          Length = 513

 Score =  598 bits (1543), Expect = e-171
 Identities = 296/471 (62%), Positives = 367/471 (77%), Gaps = 11/471 (2%)

Query: 284 DSDSELSSSEGLEPGSADPLANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFS 343
           ++ SE+ S+E LE  + + L+NG     EAA RLA+RLY L+ F+R DVA+ LGKNNEFS
Sbjct: 21  EAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFS 80

Query: 344 RLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSE 403
           +LVA EYL FFDF+G+TLD +LR F KAF L+GETQERERVL HFS RY  CNPD   S+
Sbjct: 81  KLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQ 140

Query: 404 DGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEK 463
           DG+H LTCA+MLLNTDLHGHNIGKKM+CQ+FIANL  +N+G DF+KDLLK LYNSIKNEK
Sbjct: 141 DGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEK 200

Query: 464 LEWAIDEDELRKSLSELVDDKF-GTGTKKVTRILDGGNPFLDVPQALSATTYKHGVLTRK 522
           LEWA+D++E +KS SE  ++K  GT  K ++RI    NPFLD+P   +A  YK G L RK
Sbjct: 201 LEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARK 260

Query: 523 THADMDGKRTPRGRRGWKKFYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATR 582
            HADMDGK+TPRG+RGWK FYAVLKGT+LYLQKDEY+P+KALSE DLKNA+ VHHALA++
Sbjct: 261 IHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASK 320

Query: 583 ASDYSKKSNVLKLKTADWRVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKF 642
           A+DY KK NV KLKTADWRV LFQ  S EEM  WI +IN VAA+FSAP FPAA+ S KKF
Sbjct: 321 ATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKF 380

Query: 643 CRPLLPSCTTRLCQEEQLRSHENKLRQLTAELAEHRCHPVERGIKSKEAEEYRLKEHYLT 702
            RPLLP+ TT+L QEEQL+SHE+KL+Q+T ELAEHR +P ++ +K+K+ +EY+LK+HYL 
Sbjct: 381 SRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLE 440

Query: 703 FEKSRYETYIHLLAMKIKVGSDDLERIEARLATLEGDDPSLRKTHSSPALS 753
           FEK+RYE Y+ +L    K G  +L      L+  E +   L+K+HSSP+L+
Sbjct: 441 FEKTRYEMYVSIL----KEGGKEL------LSNDESEAAGLKKSHSSPSLN 481


>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
          Length = 1056

 Score =  432 bits (1112), Expect = e-121
 Identities = 245/525 (46%), Positives = 324/525 (61%), Gaps = 25/525 (4%)

Query: 244  PNGFHEDGPQGPGGDEDDDEEDTDKLLNSASDPSLKDGLSDS-------DSELSSSEGLE 296
            P    E   +G     +  +   D  L SA   +L+  ++ S           S  EG  
Sbjct: 512  PKPGEEVKSEGTARPAETGDVQPDIHLTSAEHENLRTPMNSSWLPGSPMPQAQSPEEGQR 571

Query: 297  PGSADPLANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDF 356
            P + D LANG +  ++ A  LA RLY LEGF++ +VA  L KNN+FSR VA EYLSFF F
Sbjct: 572  PPAGDKLANGVRN-NKVAWNLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQF 630

Query: 357  SGLTLDGALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLL 416
             G +LD ALR+FL+A  L GETQERER+L  FSRR+  CNP    S D +HTLTCA+MLL
Sbjct: 631  GGQSLDRALRSFLQALVLSGETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLL 690

Query: 417  NTDLHGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKS 476
            NTDLHG NIGK MSCQ+FI NL+ L DG +F K+LLK LY SI++EKLEWA+DE++  + 
Sbjct: 691  NTDLHGQNIGKSMSCQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTAR- 749

Query: 477  LSELVDDKFGTGTKKVTRILDGGNPFLDVPQALSATTYKHGVLTRKTHADMDGKRTPRGR 536
              E        G            PFL + Q  +  TYK G+L RK H D DGK+TP G+
Sbjct: 750  -PEKAQPSLPAGKM--------SKPFLQLAQDPTVPTYKQGILARKMHQDADGKKTPWGK 800

Query: 537  RGWKKFYAVLKGTILYLQK---DEYRPDKALSEGDLKNAIRVHHALATRASDYSKKSNVL 593
            RGWK F+ +L+G +LY  K   D     ++L    +   + VHH+LAT A+ Y+KK +V 
Sbjct: 801  RGWKMFHTLLRGMVLYFLKQGEDHCLEGESLVGQMVDEPVGVHHSLATPATHYTKKPHVF 860

Query: 594  KLKTADWRVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTR 653
            +L+TADWR++LFQAP+ +EM SWI RINL AA  SAP FPAAV S ++F RP+LP    +
Sbjct: 861  QLRTADWRLYLFQAPTAKEMSSWIARINLAAATHSAPPFPAAVGSQRRFVRPILPVGPAQ 920

Query: 654  LCQEEQLRSHENKLRQLTAELAEHRCHPVERGIKSKEAEEYRLKEHYLTFEKSRYETYIH 713
               EEQ RSHEN L     +L + + +  ER  + +E EE+RL++ YL +EK+RYETY+ 
Sbjct: 921  SSLEEQHRSHENCLDAAADDLLDLQRNLPERRGRGRELEEHRLRKEYLEYEKTRYETYVQ 980

Query: 714  LLAMKIKVGSDDLERIEARLATLEGD--DP--SLRKTHSSPALSQ 754
            LL  ++   SD L+  E +L    G   +P  SL+K+HSSP+L Q
Sbjct: 981  LLVARLHCPSDALDLWEEQLGREAGGTREPKLSLKKSHSSPSLHQ 1025


>gi|4758968 cytohesin 3 [Homo sapiens]
          Length = 399

 Score =  112 bits (281), Expect = 1e-24
 Identities = 61/156 (39%), Positives = 94/156 (60%), Gaps = 2/156 (1%)

Query: 317 LARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMG 376
           +A+ LY  EG  +  +   LG+ +EF+  V   ++   +F+ L L  ALR FL +F L G
Sbjct: 101 VAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPG 160

Query: 377 ETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIA 436
           E Q+ +R++  F+ RYC CNP    S D  + L+ A+++LNT LH HN+  K + ++FIA
Sbjct: 161 EAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIA 220

Query: 437 NLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDE 472
               +N+G D  ++LL+ LY SIKNE  +  I ED+
Sbjct: 221 MNRGINEGGDLPEELLRNLYESIKNEPFK--IPEDD 254


>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
          Length = 397

 Score =  112 bits (279), Expect = 2e-24
 Identities = 65/172 (37%), Positives = 99/172 (57%), Gaps = 9/172 (5%)

Query: 301 DPLANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLT 360
           D L N C+ +       A+ LY  EG  +  +   LG+ +EF+  V   ++   +F+ L 
Sbjct: 88  DLLKNTCEDI-------AQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLN 140

Query: 361 LDGALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDL 420
           L  ALR FL +F L GE Q+ +R++  F++RYCQCN     S D  + L+ A+++LNT L
Sbjct: 141 LVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSL 200

Query: 421 HGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDE 472
           H  N+  K + ++FIA    +NDG D  ++LL+ LY SIKNE  +  I ED+
Sbjct: 201 HNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFK--IPEDD 250


>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
          Length = 398

 Score =  112 bits (279), Expect = 2e-24
 Identities = 65/172 (37%), Positives = 99/172 (57%), Gaps = 9/172 (5%)

Query: 301 DPLANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLT 360
           D L N C+ +       A+ LY  EG  +  +   LG+ +EF+  V   ++   +F+ L 
Sbjct: 88  DLLKNTCEDI-------AQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLN 140

Query: 361 LDGALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDL 420
           L  ALR FL +F L GE Q+ +R++  F++RYCQCN     S D  + L+ A+++LNT L
Sbjct: 141 LVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSL 200

Query: 421 HGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDE 472
           H  N+  K + ++FIA    +NDG D  ++LL+ LY SIKNE  +  I ED+
Sbjct: 201 HNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFK--IPEDD 250


>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
          Length = 399

 Score =  107 bits (268), Expect = 3e-23
 Identities = 58/156 (37%), Positives = 92/156 (58%), Gaps = 2/156 (1%)

Query: 317 LARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMG 376
           +AR LY  EG  +  +   LG+  E +  V   ++   +F+ L L  ALR FL +F L G
Sbjct: 96  IARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPG 155

Query: 377 ETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIA 436
           E Q+ +R++  F++RYC CNP    S D  + L+ A+++LNT LH  N+  K   ++F+A
Sbjct: 156 EAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVA 215

Query: 437 NLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDE 472
               +N+G D  ++LL+ LY+SI+NE  +  I ED+
Sbjct: 216 MNRGINEGGDLPEELLRNLYDSIRNEPFK--IPEDD 249


>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
          Length = 400

 Score =  107 bits (268), Expect = 3e-23
 Identities = 58/156 (37%), Positives = 92/156 (58%), Gaps = 2/156 (1%)

Query: 317 LARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMG 376
           +AR LY  EG  +  +   LG+  E +  V   ++   +F+ L L  ALR FL +F L G
Sbjct: 96  IARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPG 155

Query: 377 ETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIA 436
           E Q+ +R++  F++RYC CNP    S D  + L+ A+++LNT LH  N+  K   ++F+A
Sbjct: 156 EAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVA 215

Query: 437 NLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDE 472
               +N+G D  ++LL+ LY+SI+NE  +  I ED+
Sbjct: 216 MNRGINEGGDLPEELLRNLYDSIRNEPFK--IPEDD 249


>gi|7019505 cytohesin 4 [Homo sapiens]
          Length = 394

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 53/156 (33%), Positives = 91/156 (58%), Gaps = 2/156 (1%)

Query: 317 LARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMG 376
           +AR LY  EG  +  +   LG+ +  +  V   ++   +F+ L L  ALR FL +F L G
Sbjct: 96  IARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPG 155

Query: 377 ETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIA 436
           E Q+ +R++  F+ RYC CNP    S D  + L+ ++++LNT LH  N+  +   ++F++
Sbjct: 156 EAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVS 215

Query: 437 NLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDE 472
               +N+G D  +D L+ L++SIK+E   ++I ED+
Sbjct: 216 MNRGINNGSDLPEDQLRNLFDSIKSE--PFSIPEDD 249


>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
           exchange factor 1 [Homo sapiens]
          Length = 1859

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 54/150 (36%), Positives = 87/150 (58%), Gaps = 16/150 (10%)

Query: 331 DVARQLGKNNEFSRLVAGEYLS-------------FFDFSGLTLDGALRTFLKAFPLMGE 377
           +VA+ L +N    + + GE++S              F F GL LD ALR +L+AF L GE
Sbjct: 735 EVAQWLRENPRLDKKMIGEFVSDRKNIDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGE 794

Query: 378 TQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNIGKK---MSCQQF 434
               +R+L  F+ R+  CN     + D   +L  A+++LNTD H HN+ K+   M+ ++F
Sbjct: 795 APVIQRLLEAFTERWMNCNGSPFANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEF 854

Query: 435 IANLDQLNDGQDFAKDLLKTLYNSIKNEKL 464
             NL  +N G+DF +D+L+ +Y++IKNE++
Sbjct: 855 RKNLKGVNGGKDFEQDILEDMYHAIKNEEI 884


>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
           protein 1 [Homo sapiens]
          Length = 1849

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 50/150 (33%), Positives = 82/150 (54%), Gaps = 2/150 (1%)

Query: 317 LARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMG 376
           +A+ L+  E      V   LG N++F++ V   Y+   DFSG     ALR FL+ F L G
Sbjct: 733 IAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPG 792

Query: 377 ETQERERVLTHFSRRYCQCNPDDS--TSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQF 434
           E Q+ +R++  F+ RY +CN   +   S D  + L  ++++L TDLH   +  KM+ +Q+
Sbjct: 793 EAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQY 852

Query: 435 IANLDQLNDGQDFAKDLLKTLYNSIKNEKL 464
           I     +ND +D  ++ L  +YN I  +K+
Sbjct: 853 IKMNRGINDSKDLPEEYLSAIYNEIAGKKI 882


>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
          Length = 759

 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 76/277 (27%), Positives = 121/277 (43%), Gaps = 61/277 (22%)

Query: 250 DGPQGPGGDEDDDEEDTDKLLNSASDPS-----LKDGLSDSDSELSSSEGLEPGSADPLA 304
           DG   P  +E+++EE+T ++   A   +     L    + + S  S SE     S D L 
Sbjct: 261 DGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDALQ 320

Query: 305 N--------------GCQGVSEAAHRLARRLYHL------------------EGF----- 327
                           C+  + +   L +RLY +                   GF     
Sbjct: 321 AMILSLPRYHCENPASCKSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTP 380

Query: 328 --------QRCDVARQL------GKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFP 373
                   QR  ++RQ+          +F+R V    +   DFS + LD ALR F     
Sbjct: 381 IGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIR 440

Query: 374 LMGETQERERVLTHFSRRYCQCNPD---DSTSEDGIHTLTCALMLLNTDLHGHNI--GKK 428
           + GE Q+ ER++  FS+RYC CNP+      + D I  L  A++LLNTD++  NI   +K
Sbjct: 441 VQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRK 500

Query: 429 MSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLE 465
           M  + FI NL  ++DG D  ++L+  +Y  I+ ++L+
Sbjct: 501 MMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELK 537


>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
          Length = 1114

 Score = 89.7 bits (221), Expect = 9e-18
 Identities = 58/179 (32%), Positives = 94/179 (52%), Gaps = 6/179 (3%)

Query: 317 LARRLYHLEGFQRCDVARQLG-KNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLM 375
           +A  L   +G  R  +   LG +  +F+R V    +   DFS + LD ALR F     + 
Sbjct: 545 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 604

Query: 376 GETQERERVLTHFSRRYCQCNPD---DSTSEDGIHTLTCALMLLNTDLHGHNI--GKKMS 430
           GE Q+ ER++  FS+RYC CNP       + D I  L  A++LLNTD++  N+   +KM 
Sbjct: 605 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 664

Query: 431 CQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDDKFGTGT 489
            + FI NL  ++DG+D  +++L  +Y  I+  +L+   D     + + +L+  K   G+
Sbjct: 665 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGS 723


>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
          Length = 963

 Score = 89.7 bits (221), Expect = 9e-18
 Identities = 58/179 (32%), Positives = 94/179 (52%), Gaps = 6/179 (3%)

Query: 317 LARRLYHLEGFQRCDVARQLG-KNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLM 375
           +A  L   +G  R  +   LG +  +F+R V    +   DFS + LD ALR F     + 
Sbjct: 559 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 618

Query: 376 GETQERERVLTHFSRRYCQCNPD---DSTSEDGIHTLTCALMLLNTDLHGHNI--GKKMS 430
           GE Q+ ER++  FS+RYC CNP       + D I  L  A++LLNTD++  N+   +KM 
Sbjct: 619 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 678

Query: 431 CQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDDKFGTGT 489
            + FI NL  ++DG+D  +++L  +Y  I+  +L+   D     + + +L+  K   G+
Sbjct: 679 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGS 737


>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
          Length = 949

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 61/203 (30%), Positives = 99/203 (48%), Gaps = 21/203 (10%)

Query: 310 VSEAAHRLARRLYHLEGFQRCDVARQLG-KNNEFSRLVAGEYLSFFDFSGLTLDGALRTF 368
           +S+    +A  +   +G  R  +   LG +  +F+R V    +   DFS + LD ALR F
Sbjct: 576 LSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKF 635

Query: 369 LKAFPLMGETQERERVLTHFSRRYCQCNP---DDSTSEDGIHTLTCALMLLNTDLHGHNI 425
                + GE Q+ ER++  FS+RYC CNP       + D I  L  A++LLNTD++  ++
Sbjct: 636 QSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSV 695

Query: 426 --GKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDD 483
              +KM    FI NL  +++G+D  +DLL  +Y  I+  +L                 +D
Sbjct: 696 KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELR---------------TND 740

Query: 484 KFGTGTKKVTRILDGGNPFLDVP 506
              +  + V R++ G  P L +P
Sbjct: 741 DHVSQVQAVERMIVGKKPVLSLP 763


>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
          Length = 1488

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 61/203 (30%), Positives = 99/203 (48%), Gaps = 21/203 (10%)

Query: 310 VSEAAHRLARRLYHLEGFQRCDVARQLG-KNNEFSRLVAGEYLSFFDFSGLTLDGALRTF 368
           +S+    +A  +   +G  R  +   LG +  +F+R V    +   DFS + LD ALR F
Sbjct: 781 LSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKF 840

Query: 369 LKAFPLMGETQERERVLTHFSRRYCQCNP---DDSTSEDGIHTLTCALMLLNTDLHGHNI 425
                + GE Q+ ER++  FS+RYC CNP       + D I  L  A++LLNTD++  ++
Sbjct: 841 QSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSV 900

Query: 426 --GKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDD 483
              +KM    FI NL  +++G+D  +DLL  +Y  I+  +L                 +D
Sbjct: 901 KAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELR---------------TND 945

Query: 484 KFGTGTKKVTRILDGGNPFLDVP 506
              +  + V R++ G  P L +P
Sbjct: 946 DHVSQVQAVERMIVGKKPVLSLP 968


>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
           factor 2 [Homo sapiens]
          Length = 1785

 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 47/150 (31%), Positives = 80/150 (53%), Gaps = 2/150 (1%)

Query: 317 LARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMG 376
           +A+ L+  E      V   LG +  F++ V   Y+   DF       ALRTFL+ F L G
Sbjct: 678 IAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPG 737

Query: 377 ETQERERVLTHFSRRYCQCNPDDS--TSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQF 434
           E Q+ +R++  F+ RY +CN   +   S D  + L  ++++L TDLH   +  KM+ +Q+
Sbjct: 738 EAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQY 797

Query: 435 IANLDQLNDGQDFAKDLLKTLYNSIKNEKL 464
           I     +ND +D  ++ L ++Y  I+ +K+
Sbjct: 798 IKMNRGINDSKDLPEEYLSSIYEEIEGKKI 827


>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
            sapiens]
          Length = 2564

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 39/112 (34%), Positives = 51/112 (45%), Gaps = 4/112 (3%)

Query: 506  PQALSATTYKHGVLTRKTHADMDGKRTPRGRRGWKKFYAVLKGTILYLQKDEYRPDKALS 565
            P   + T    G L RK   D + K +    R W   Y VL    L   KD   P    +
Sbjct: 2412 PPPPTHTVQHEGFLLRKRELDANRKSS---NRSWVSLYCVLSKGELGFYKDSKGPASGST 2468

Query: 566  EGDLKNAIRVHHALATRASDYSKKSNVLKLKTADWRVFLFQAPSKEEMLSWI 617
             G  +  + +H A +  ASDY KK +V KL+T D   FL QA  +EEM  W+
Sbjct: 2469 HGG-EPLLSLHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWL 2519


>gi|48928044 F-box only protein 8 [Homo sapiens]
          Length = 319

 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 39/121 (32%), Positives = 63/121 (52%), Gaps = 7/121 (5%)

Query: 344 RLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMGETQER-ERVLTHFSRRYCQCNPDD--- 399
           R V  + ++  +F    L  ALR F +      E  E  E ++T FS R+C CNPD    
Sbjct: 193 RDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRE 252

Query: 400 -STSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNS 458
              S D ++ L  +L+LL+ DL   ++  KMS ++FI N  +    Q+ ++D +  LY++
Sbjct: 253 LGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRA--AQNISEDFVGHLYDN 310

Query: 459 I 459
           I
Sbjct: 311 I 311


>gi|67782321 spectrin beta isoform a [Homo sapiens]
          Length = 2328

 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 42/150 (28%), Positives = 66/150 (44%), Gaps = 14/150 (9%)

Query: 469  DEDELRKSLSELVDDKFGTGTKKVTRILDGGNPFLDVPQALSATTYKHGVLTRKTHADMD 528
            DE    + L +++D     G +  T         L  P+    +    G L RK   D++
Sbjct: 2144 DERPTTEPLFKVLDTPLSEGDEPAT---------LPAPRDHGQSVQMEGYLGRKH--DLE 2192

Query: 529  GKRTPRGRRGWKKFYAVLKGTILYLQKDEYRPDKALS-EGDLKNAIRVHHALATRASDYS 587
            G       R W   Y VL+ + L   KD       +   G+   A+R  HA+   A++Y 
Sbjct: 2193 GPNKKASNRSWNNLYCVLRNSELTFYKDAKNLALGMPYHGEEPLALR--HAICEIAANYK 2250

Query: 588  KKSNVLKLKTADWRVFLFQAPSKEEMLSWI 617
            KK +V KL+ ++   +LF    +EEMLSW+
Sbjct: 2251 KKKHVFKLRLSNGSEWLFHGKDEEEMLSWL 2280


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 36/124 (29%), Positives = 56/124 (45%), Gaps = 7/124 (5%)

Query: 504 DVPQALSATTYKHGVLTRKTHADMDGKRTPRGRRGWKKFYAVLKGTILYLQKDEYRPDKA 563
           D+  A  +   + G L  K      GK+   G R WK+ YA L+   L L K+   P  A
Sbjct: 586 DLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPA 645

Query: 564 LSEGDLKNA-------IRVHHALATRASDYSKKSNVLKLKTADWRVFLFQAPSKEEMLSW 616
            +      A       + +   L   +   +K+ +V +L TAD+  +LFQA  +++ML W
Sbjct: 646 AAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGW 705

Query: 617 ILRI 620
           I  I
Sbjct: 706 IRAI 709


>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
          Length = 2390

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 44/144 (30%), Positives = 64/144 (44%), Gaps = 13/144 (9%)

Query: 510  SATTYKHGVLTRKTHADMDGKRTPRGRRGWKKFYAVLKGTILYLQKDEYRPDKALSEGDL 569
            SA     G+L RK   +  GK+     R W+  Y VL+   L   KD     KA S G  
Sbjct: 2216 SAQEQMEGMLCRKQEMEAFGKKA--ANRSWQNVYCVLRRGSLGFYKDA----KAASAGVP 2269

Query: 570  KNA---IRVHHALATRASDYSKKSNVLKLKTADWRVFLFQAPSKEEMLSWILRINLVAAI 626
             +    + +  A  + A DY K+ +V KL   D + +LFQA  + EM SW+  +N   A 
Sbjct: 2270 YHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIAT 2329

Query: 627  FSA----PAFPAAVSSMKKFCRPL 646
             S+    P  P   S+ +   R +
Sbjct: 2330 ASSASGEPEEPVVPSTTRGMTRAM 2353


>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
          Length = 1958

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 34/92 (36%), Positives = 48/92 (52%), Gaps = 4/92 (4%)

Query: 529  GKRTPRGRRGWKKFYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATRASDYSK 588
            GKR     R WK+ Y VL+G  LYL KD+        E   +  I V+  L   +   +K
Sbjct: 948  GKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTTPSEE---EQPISVNACLIDISYSETK 1004

Query: 589  KSNVLKLKTADWRVFLFQAPSKEEMLSWILRI 620
            + NV +L T+D    LFQA  +++ML+WI  I
Sbjct: 1005 RKNVFRLTTSDCEC-LFQAEDRDDMLAWIKTI 1035


>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a
           [Homo sapiens]
          Length = 1701

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 51/205 (24%), Positives = 88/205 (42%), Gaps = 31/205 (15%)

Query: 536 RRGWKKFYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATRASDYSKKSNVLKL 595
           RR WK+++  LKG  L L  + Y  +        + A+    ++     ++ KK NV  L
Sbjct: 532 RRKWKQYWVTLKGCTL-LFYETYGKNSMDQSSAPRCALFAEDSIVQSVPEHPKKENVFCL 590

Query: 596 KTADWRVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRLC 655
             +   V+LFQA S+ ++ +W      V A+ SA A   A    K+    LL + T  L 
Sbjct: 591 SNSFGDVYLFQATSQTDLENW------VTAVHSACASLFAKKHGKEDTLRLLKNQTKNLL 644

Query: 656 QEEQLRSHENKLRQLTAELAEHRCHPVERGIKSKEAEEYRLKEHYLTFEKSRYETYIHLL 715
           Q+  + S   K+ +L   +            K+++A E ++++     EK       H+ 
Sbjct: 645 QKIDMDSKMKKMAELQLSVVSDP--------KNRKAIENQIQQWEQNLEK------FHM- 689

Query: 716 AMKIKVGSDDLERIEARLATLEGDD 740
                    DL R+   LA+L+G +
Sbjct: 690 ---------DLFRMRCYLASLQGGE 705


>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
            sapiens]
          Length = 2364

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 31/105 (29%), Positives = 45/105 (42%), Gaps = 3/105 (2%)

Query: 517  GVLTRKTHADMDGKRTPRGRRGWKKFYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVH 576
            G L RK   +   K+     R W   Y V+    +   KD       +     +  + + 
Sbjct: 2202 GFLNRKHEWEAHNKKA--SSRSWHNVYCVINNQEMGFYKDAKTAASGIPYHS-EVPVSLK 2258

Query: 577  HALATRASDYSKKSNVLKLKTADWRVFLFQAPSKEEMLSWILRIN 621
             A+   A DY KK +V KL+  D   +LFQA   EEM +WI  I+
Sbjct: 2259 EAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAIS 2303


>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo
           sapiens]
          Length = 1591

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 37/136 (27%), Positives = 62/136 (45%), Gaps = 9/136 (6%)

Query: 536 RRGWKKFYAVLKGTILYLQKDEYRPDKALSEGDL-KNAIRVHHALATRASDYSKKSNVLK 594
           RR WK ++  LKG  L+  + + R    +    + K+A+ V +++     ++ KK  V  
Sbjct: 459 RRKWKHYWVSLKGCTLFFYESDGR--SGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFC 516

Query: 595 LKTADWRVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRL 654
           L  +    FLFQ  S+ E+ +WI       AI SA A   A    K+    LL S   +L
Sbjct: 517 LSNSLGDAFLFQTTSQTELENWI------TAIHSACATAVARHHHKEDTLRLLKSEIKKL 570

Query: 655 CQEEQLRSHENKLRQL 670
            Q+  +     K+ ++
Sbjct: 571 EQKIDMDEKMKKMGEM 586



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 72/316 (22%), Positives = 123/316 (38%), Gaps = 32/316 (10%)

Query: 186 QRARDSPEPGAGLGIGDMAFEGDMGAAGGDGELGSPLRRSISSSRSENVLSRLSLMAMPN 245
           +RA+ + +  AG G    +   D G  G   +     RRS +++ S +  +  + +   +
Sbjct: 315 RRAKTTQDVNAGEG----SEFADSGIEGATTDTDLLSRRSNATNSSYSPTTGRAFVGSDS 370

Query: 246 GFHEDGPQGPGGDEDDDEEDTDKLLNSASDPSLKDGLSDSDSELSSSEGLEPGSADPLAN 305
           G    G     G  ++   + +  +++ +  SL++  S    E SS     PG +D L  
Sbjct: 371 GSSSTGDAARQGVYENFRRELE--MSTTNSESLEEAGSAHSDEQSSGTLSSPGQSDILLT 428

Query: 306 GCQGVSEAAHRLARR--LYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDG 363
             QG    A  LA +  L H +  +     R+  K+   S  + G  L F++  G +  G
Sbjct: 429 AAQGTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVS--LKGCTLFFYESDGRS--G 484

Query: 364 ALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLN--TDLH 421
                +    +  E    + V  H  + +  C   +S  +  +   T    L N  T +H
Sbjct: 485 IDHNSIPKHAVWVENSIVQAVPEHPKKDFVFC-LSNSLGDAFLFQTTSQTELENWITAIH 543

Query: 422 GHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELV 481
                   +C   +A            +D L+ L + IK  KLE  ID DE  K + E+ 
Sbjct: 544 S-------ACATAVAR-------HHHKEDTLRLLKSEIK--KLEQKIDMDEKMKKMGEMQ 587

Query: 482 DDKFGTGTKKVTRILD 497
                T +KK   ILD
Sbjct: 588 LSSV-TDSKKKKTILD 602


>gi|154146216 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 2 [Homo
           sapiens]
          Length = 425

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 32/103 (31%), Positives = 53/103 (51%), Gaps = 7/103 (6%)

Query: 536 RRGWKK-FYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATRASDYSKKSNVLK 594
           R+ WK+ F+A+   TI Y + ++ R  + L    LK+ ++ H  L  ++ D   + N+ +
Sbjct: 212 RKSWKRRFFALDDFTICYFKCEQDR--EPLRTIFLKDVLKTHECLV-KSGDLLMRDNLFE 268

Query: 595 LKTADWRVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVS 637
           + T+  R F  QA S E+M SWI  I   AA+ +    P   S
Sbjct: 269 IITSS-RTFYVQADSPEDMHSWIKEIG--AAVQALKCHPRETS 308


>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
          Length = 1240

 Score = 38.1 bits (87), Expect = 0.031
 Identities = 23/53 (43%), Positives = 27/53 (50%), Gaps = 2/53 (3%)

Query: 254  GPGGDEDDDEEDTDKLLNSASDPSLKDGLSDSDSELSSSEGLEPGSADPLANG 306
            GPGGDED+DEEDT     SA D SL    S+     SS  G  P +    + G
Sbjct: 1167 GPGGDEDEDEEDTAP--ESALDTSLDKSFSEDAVTDSSGSGTLPRARGRASKG 1217


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.133    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,284,637
Number of Sequences: 37866
Number of extensions: 1609860
Number of successful extensions: 6763
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 48
Number of HSP's successfully gapped in prelim test: 113
Number of HSP's that attempted gapping in prelim test: 6238
Number of HSP's gapped (non-prelim): 486
length of query: 771
length of database: 18,247,518
effective HSP length: 110
effective length of query: 661
effective length of database: 14,082,258
effective search space: 9308372538
effective search space used: 9308372538
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.