Search of human proteins with 87567783

Search of human proteins with 87567783

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
precursor [Homo sapiens]
         (482 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   981   0.0  
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   915   0.0  
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   432   e-121
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   410   e-114
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    409   e-114
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   385   e-107
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   373   e-103
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   362   e-100
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   360   1e-99
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     358   8e-99
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   300   2e-81
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   300   2e-81
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   293   3e-79
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   288   1e-77
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   280   2e-75
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   248   1e-65
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   245   6e-65
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              225   8e-59
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   189   6e-48
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   187   2e-47
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   175   9e-44
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              174   2e-43
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   119   6e-27
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   115   7e-26
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   112   6e-25
gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1 ...    76   8e-14
gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]        64   2e-10
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]        64   2e-10
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]          64   2e-10
gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]        61   3e-09

>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  981 bits (2537), Expect = 0.0
 Identities = 482/482 (100%), Positives = 482/482 (100%)

Query: 1   MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL 60
           MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL
Sbjct: 1   MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL 60

Query: 61  INVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGV 120
           INVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGV
Sbjct: 61  INVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGV 120

Query: 121 KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF 180
           KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF
Sbjct: 121 KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF 180

Query: 181 PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD 240
           PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD
Sbjct: 181 PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD 240

Query: 241 TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV 300
           TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV
Sbjct: 241 TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV 300

Query: 301 FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV 360
           FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV
Sbjct: 301 FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV 360

Query: 361 FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA 420
           FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA
Sbjct: 361 FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA 420

Query: 421 IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ 480
           IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ
Sbjct: 421 IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ 480

Query: 481 QG 482
           QG
Sbjct: 481 QG 482


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  915 bits (2366), Expect = 0.0
 Identities = 457/482 (94%), Positives = 457/482 (94%), Gaps = 25/482 (5%)

Query: 1   MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL 60
           MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL
Sbjct: 1   MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL 60

Query: 61  INVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGV 120
           INVDEVNQIVTTNVRLKQ                         QWVDYNLKWNPDDYGGV
Sbjct: 61  INVDEVNQIVTTNVRLKQ-------------------------QWVDYNLKWNPDDYGGV 95

Query: 121 KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF 180
           KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF
Sbjct: 96  KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF 155

Query: 181 PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD 240
           PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD
Sbjct: 156 PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD 215

Query: 241 TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV 300
           TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV
Sbjct: 216 TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV 275

Query: 301 FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV 360
           FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV
Sbjct: 276 FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV 335

Query: 361 FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA 420
           FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA
Sbjct: 336 FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA 395

Query: 421 IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ 480
           IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ
Sbjct: 396 IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ 455

Query: 481 QG 482
           QG
Sbjct: 456 QG 457


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  432 bits (1110), Expect = e-121
 Identities = 233/510 (45%), Positives = 313/510 (61%), Gaps = 65/510 (12%)

Query: 1   MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL 60
           + P  LLLL  L    +   SE E RL  +LF+DY+ ++RPV +    V +   + + QL
Sbjct: 12  LSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQL 71

Query: 61  INVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGV 120
           + VDEVNQI+ TN+ LKQ                          W DY LKWNP DYGG 
Sbjct: 72  VKVDEVNQIMETNLWLKQ-------------------------IWNDYKLKWNPSDYGGA 106

Query: 121 KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF 180
           + + +P++KIW+PD+VLYNNA GDF +   TK LL+YTG +TW PPAIFKS C+I VT+F
Sbjct: 107 EFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYF 166

Query: 181 PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD 240
           PFD QNC+MK G+W+YD + + +       +L ++ ESGEW I ++ G+KH + Y+CC +
Sbjct: 167 PFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEE 226

Query: 241 TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV 300
             Y DITY   ++RLPL++ +N+IIPCLL SFLT LVFYLP+D GEK+TL ISVLLSLTV
Sbjct: 227 I-YPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTV 285

Query: 301 FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV 360
           FLLVI E IPSTS  +PLIG+Y+LFTM+FV  SI+ITV V+N H+R+P+TH MP+WV+ V
Sbjct: 286 FLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTV 345

Query: 361 FIDTIPNIMFFS--TMKRPSREKQDKKIFTEDIDISDISG------KPGPP----PMGF- 407
           F++ +P +MF +  T    + +K       E  +++  S       K G P      G+ 
Sbjct: 346 FLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYC 405

Query: 408 HSPLIK--------------------------HPEVKSAIEGIKYIAETMKSDQESNNAA 441
           H   IK                           PE+K AI+ +KYIAE MK+  E+    
Sbjct: 406 HHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQ 465

Query: 442 AEWKYVAMVMDHILLGVFMLVCIIGTLAVF 471
            +WKYVAMV+D I L VF LVCI+GT  +F
Sbjct: 466 DDWKYVAMVIDRIFLWVFTLVCILGTAGLF 495


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  410 bits (1055), Expect = e-114
 Identities = 214/491 (43%), Positives = 294/491 (59%), Gaps = 66/491 (13%)

Query: 21  SEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGD 80
           +E E RL   LF+ Y+   RPV +   VV V  GL + QLI+VDE NQ++TTNV LKQ  
Sbjct: 56  TETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQ-- 113

Query: 81  MVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNN 140
                                  +W DY L+WNP D+G +  + +PSE IW PD+VLYNN
Sbjct: 114 -----------------------EWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNN 150

Query: 141 ADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSV 200
           ADG+FA+   TK  L  TG + W PPAI+KS C I VT FPFD+QNC MK G+WTYD + 
Sbjct: 151 ADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAK 210

Query: 201 VAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFI 260
           + +       DL ++ ESGEW I  + G  +S  Y CC +  Y D+TY FV++RLPL++ 
Sbjct: 211 IDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEI-YPDVTYAFVIRRLPLFYT 269

Query: 261 VNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIG 320
           +N+IIPCLL S LT LVFYLP+D GEK+TL ISVLLSLTVFLL+I E+IPSTS  +PLIG
Sbjct: 270 INLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIG 329

Query: 321 KYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRP--- 377
           +Y+LFTM+FV  SI+ITV V+N HHRSPSTH MP+WVR   +  +P  +  +    P   
Sbjct: 330 EYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVEL 389

Query: 378 -----------------SREKQDKKIFTEDID-----------ISDI-------SGKPGP 402
                            + + +++++  E+ D           +  +       SG  GP
Sbjct: 390 CHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGP 449

Query: 403 PPMGF--HSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFM 460
                     L+  P ++ A+EG+ YIA+ ++S+   ++   +WKYVAMV+D I L +F+
Sbjct: 450 KAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFI 509

Query: 461 LVCIIGTLAVF 471
           +VC +GT+ +F
Sbjct: 510 IVCFLGTIGLF 520


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  409 bits (1051), Expect = e-114
 Identities = 211/486 (43%), Positives = 301/486 (61%), Gaps = 54/486 (11%)

Query: 19  LGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQ 78
           +G   E RL  KLF  Y+  +RPVE+    V V   + + QL NVDEVNQI+ TN+ L+ 
Sbjct: 29  VGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLR- 87

Query: 79  GDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLY 138
                               H+    W DY L+W+P +Y G++ + +P++KIW+PD+VLY
Sbjct: 88  --------------------HI----WNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLY 123

Query: 139 NNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDG 198
           NNA GDF +   TK LL+Y G ITWTPPAIFKS C + +T FPFD QNCS+K G+WTYD 
Sbjct: 124 NNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDK 183

Query: 199 SVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLY 258
           + + +     + D+++F E+ EW I ++ G+KH + Y+CC +  Y DITY F ++RLP++
Sbjct: 184 AEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDIKYNCCEEI-YTDITYSFYIRRLPMF 242

Query: 259 FIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPL 318
           + +N+IIPCL  SFLT LVFYLP+D GEK+TL ISVLLSLTVFLLVI E IPSTS  VPL
Sbjct: 243 YTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPL 302

Query: 319 IGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFF------- 371
           +G+Y+LFTM+FV  SI++TV V+N H+R+P+TH MP WV+ VF+  +P ++         
Sbjct: 303 VGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKT 362

Query: 372 ----------STMKRPSREK--------QDKKIF--TEDIDISDISGKPGPPPMGFHSPL 411
                        +RP++ K          K+ F   +  +++    +    P+ +    
Sbjct: 363 RGTGSDAVPRGLARRPAKGKLASHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWVVEN 422

Query: 412 IKH-PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAV 470
            +H PEV+  I  +++IAE MKS  E+     +WKYVAMV+D + L VF++VC+ GT  +
Sbjct: 423 SEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGL 482

Query: 471 FAGRLI 476
           F   L+
Sbjct: 483 FLQPLL 488


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  385 bits (990), Expect = e-107
 Identities = 206/409 (50%), Positives = 263/409 (64%), Gaps = 39/409 (9%)

Query: 5   PLLLLFSLCSAGLVLGSEH-------ETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQL 57
           PLLLL      GL+  S H       E RL+ KLF  Y+   RPV +   VV V  GL +
Sbjct: 14  PLLLLLG---TGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSI 70

Query: 58  IQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDY 117
            QLI+VDE NQ++TTNV +KQ                         +W DY L+W+P DY
Sbjct: 71  AQLIDVDEKNQMMTTNVWVKQ-------------------------EWHDYKLRWDPADY 105

Query: 118 GGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIV 177
             V  I IPSE IWRPD+VLYNNADGDFA+   TK  L + G + WTPPAI+KS C I V
Sbjct: 106 ENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDV 165

Query: 178 THFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSC 237
           T FPFD+QNC+MK G+WTYD + + +     + D  +F ESGEWVI ++ G  ++  Y C
Sbjct: 166 TFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYEC 225

Query: 238 CPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLS 297
           C +  Y DITY FV++RLPL++ +N+IIPCLL S LT LVFYLP++ GEK+TL ISVLLS
Sbjct: 226 CAEI-YPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLS 284

Query: 298 LTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWV 357
           LTVFLL+I E+IPSTS  +PLIG+Y+LFTM+FV  SI+ITV V+N HHRSP TH MP WV
Sbjct: 285 LTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWV 344

Query: 358 RKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMG 406
           R+VF+D +P ++    MKRPS  K + +   E +     + +  P P G
Sbjct: 345 RRVFLDIVPRLLL---MKRPSVVKDNCRRLIESMHKMASAPRFWPEPEG 390



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 30/70 (42%), Positives = 48/70 (68%), Gaps = 5/70 (7%)

Query: 402 PPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFML 461
           PPP   H PL   P +  A+EG++YIA+ +K++    +   +WKYVAMV+D I L +F++
Sbjct: 554 PPP---HLPL--SPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFII 608

Query: 462 VCIIGTLAVF 471
           VC++GT+ +F
Sbjct: 609 VCLLGTVGLF 618


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  373 bits (958), Expect = e-103
 Identities = 198/452 (43%), Positives = 278/452 (61%), Gaps = 49/452 (10%)

Query: 21  SEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGD 80
           ++HE  L+  LF+DY   VRPVE     +++  GL + QL++VDE NQ++TTNV LKQ  
Sbjct: 44  AKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQ-- 101

Query: 81  MVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNN 140
                                  +W+D  L+WNPDDYGG+K I +PS+ +W PD+VL++N
Sbjct: 102 -----------------------EWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDN 138

Query: 141 ADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSV 200
           ADG F     TK +++Y G +TWTPPA +KS C I VT FPFD QNCSMK G+WTYDGS 
Sbjct: 139 ADGRFEGTS-TKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQ 197

Query: 201 VAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFI 260
           V I  E    D  +F ++GEW I  + G K + T SCC    Y  +TY FV++RLPL++ 
Sbjct: 198 VDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCW---YPYVTYSFVIKRLPLFYT 254

Query: 261 VNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIG 320
           + +IIPC+  SFLT LVFYLP++ GEK+ L  SVL+SLTVFLLVI E+IPS+S  +PLIG
Sbjct: 255 LFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIG 314

Query: 321 KYMLFTMVFVIASIIITVIVINTHHRSPSTH-VMPNWVRKVFIDTIPNIMFFSTMKRPSR 379
           +Y++FTM+FV  SI++TV  IN HHRS STH  M   VRK+F+ T+P ++         R
Sbjct: 315 EYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCM-------R 367

Query: 380 EKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNN 439
              D + FT+  +    SG           P      +++A++ I+YI   +  + +   
Sbjct: 368 SHVD-RYFTQKEETESGSG-----------PKSSRNTLEAALDSIRYITRHIMKENDVRE 415

Query: 440 AAAEWKYVAMVMDHILLGVFMLVCIIGTLAVF 471
              +WK++A V+D + L  F+ V I+G+L +F
Sbjct: 416 VVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLF 447


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  362 bits (930), Expect = e-100
 Identities = 197/509 (38%), Positives = 296/509 (58%), Gaps = 65/509 (12%)

Query: 3   PWPLLL---LFSLCSAGLVLGSEHETRLVAKLFKD--YSSVVRPVEDHRQVVEVTVGLQL 57
           P  LLL   L  LCS   V G++ E RLV  L     Y+ ++RP  +  ++V V + + L
Sbjct: 7   PVALLLGFGLLRLCSG--VWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSL 64

Query: 58  IQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDY 117
            QLI+V E  QI+TTNV L Q                         +W DY L W P+++
Sbjct: 65  AQLISVHEREQIMTTNVWLTQ-------------------------EWEDYRLTWKPEEF 99

Query: 118 GGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIV 177
             +KK+ +PS+ IW PD+VLYNNADG + +  ++  ++ Y G I W PPAI+KS C+I V
Sbjct: 100 DNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEV 159

Query: 178 THFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSC 237
            HFPFD+QNC+MK  +WTYD + + +  +S+   L +F  SGEW I    G ++      
Sbjct: 160 KHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENP--- 216

Query: 238 CPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLS 297
             D+ Y+DITY F+++R PL++ +N+IIPC+L + L  LVFYLP+D GEKMTL ISVLL+
Sbjct: 217 -DDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLA 275

Query: 298 LTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWV 357
           LTVFLL+I +++P TS  VPL+GKY++FTMV V  SI+ +V V+N HHRSP+TH M  WV
Sbjct: 276 LTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWV 335

Query: 358 RKVFIDTIPNIMFFS-----------TMKRPSREKQDK--------------KIFTEDID 392
           + VF++ +P ++F              ++R  RE++                  F     
Sbjct: 336 KVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRAS 395

Query: 393 ISDISGKPGPPPMGFHSPLIKHPE----VKSAIEGIKYIAETMKSDQESNNAAAEWKYVA 448
           +  ++G  G  P     P          ++ A++G+++IA+ M+S+ +  + + +WKYVA
Sbjct: 396 VQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVA 455

Query: 449 MVMDHILLGVFMLVCIIGTLAVFAGRLIE 477
           MV+D + L +F+ VC+ GT+ +F   L +
Sbjct: 456 MVIDRLFLWIFVFVCVFGTIGMFLQPLFQ 484


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  360 bits (925), Expect = 1e-99
 Identities = 192/459 (41%), Positives = 279/459 (60%), Gaps = 38/459 (8%)

Query: 21  SEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGD 80
           +E+E  L+  LF+ Y   VRPV      ++V  GL++ QL++VDE NQ++TTNV LKQ  
Sbjct: 26  AENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQ-- 83

Query: 81  MVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNN 140
                                  +W D+ L+WNPDDYGG+  I +PSE +W PD+VL+ N
Sbjct: 84  -----------------------EWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFEN 120

Query: 141 ADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSV 200
           ADG F     TKV+++  G + WTPPA +KS C + VT FPFD QNCSMK G+WTYDG++
Sbjct: 121 ADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTM 180

Query: 201 VAINPESDQPDLSNFMESGEWVIKESRGWK---HSVTYSCCPDTPYLDITYHFVMQRLPL 257
           V +   ++  D  +F ++GEW I  ++G K       YS      Y  ITY FV++RLPL
Sbjct: 181 VDLILINENVDRKDFFDNGEWEILNAKGMKGNRRDGVYS------YPFITYSFVLRRLPL 234

Query: 258 YFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVP 317
           ++ + +IIPCL  SFLT LVFYLP+D GEK++LS SVL+SLTVFLLVI E+IPS+S  +P
Sbjct: 235 FYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIP 294

Query: 318 LIGKYMLFTMVFVIASIIITVIVINTHHRSPST-HVMPNWVRKVFIDTIPNIMFFSTMKR 376
           LIG+Y+LF M+FV  SII+TV VIN HHRS ST H M  WV+++F+  +P ++       
Sbjct: 295 LIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMK--DH 352

Query: 377 PSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQE 436
             R    +K  ++ +    +  K     +     ++    ++ A + I+YI+  +K +  
Sbjct: 353 VDRYSSPEKEESQPVVKGKVLEKKKQKQLSDGEKVLV-AFLEKAADSIRYISRHVKKEHF 411

Query: 437 SNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRL 475
            +    +WK+VA V+D I L +F++V + G++ +F   L
Sbjct: 412 ISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTPAL 450


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  358 bits (918), Expect = 8e-99
 Identities = 196/508 (38%), Positives = 287/508 (56%), Gaps = 68/508 (13%)

Query: 6   LLLLFSLCSAGLVLGSEHETRLVAKLFKD--YSSVVRPVEDHRQVVEVTVGLQLIQLINV 63
           L  L +LC  G    +  E +L+  L     Y++++RP     Q++ + + L L QLI+V
Sbjct: 9   LFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISV 68

Query: 64  DEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKI 123
           +E  QI+TTNV LKQ                         +W DY L WN   Y GV  +
Sbjct: 69  NEREQIMTTNVWLKQ-------------------------EWTDYRLTWNSSRYEGVNIL 103

Query: 124 HIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFD 183
            IP+++IW PD+VLYNNADG + +  +T ++++  G + W PPAI+KS C+I V +FPFD
Sbjct: 104 RIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFD 163

Query: 184 EQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPY 243
           +QNC++K  +WTYD + + +   +    + +F  SGEW I    G + +V      D  Y
Sbjct: 164 QQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPG-RRTVNPQ---DPSY 219

Query: 244 LDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLL 303
           +D+TY F+++R PL++ +N+IIPC+L + L  LVFYLP+D GEKMTL ISVLL+LT FLL
Sbjct: 220 VDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLL 279

Query: 304 VIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFID 363
           +I +++P TS  VPLIGKY++FTMV V  SI+ +V V+N HHRSPSTH M  WV++ F+ 
Sbjct: 280 LISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLH 339

Query: 364 TIPNIMFFSTMKRPSREKQDKKIF------TEDIDISDISGKP-----------GPPPMG 406
            +P  +F   MKRP  +    + F          + +  S  P            P    
Sbjct: 340 KLPTFLF---MKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAA 396

Query: 407 FHSPLIKHP-----------------EVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAM 449
             SP    P                 +V+ A+EG+ +IA+ MK+D E  +   +WKYVAM
Sbjct: 397 SKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAM 456

Query: 450 VMDHILLGVFMLVCIIGTLAVFAGRLIE 477
           V+D + L VFM VC++GT+ +F   L +
Sbjct: 457 VVDRLFLWVFMFVCVLGTVGLFLPPLFQ 484


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  300 bits (768), Expect = 2e-81
 Identities = 171/502 (34%), Positives = 266/502 (52%), Gaps = 87/502 (17%)

Query: 19  LGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQ 78
           L  E + +L  +L K+Y+ + RPV +  Q + V   L L+Q+++VDE NQ++TTN+ L+ 
Sbjct: 21  LQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQM 80

Query: 79  GDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLY 138
                                     W D+ L+WN  +Y GVK +  P  +IW+PD++LY
Sbjct: 81  S-------------------------WTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLY 115

Query: 139 NNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDG 198
           N+AD  F     T VL+  +GH  + PP IFKS C I V  FPFD Q+C +K G+W+Y G
Sbjct: 116 NSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGG 175

Query: 199 SVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLY 258
              +++ +  + D+S ++ +GEW +    G +    Y CC + PY D+T+   M+R  LY
Sbjct: 176 W--SLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKE-PYPDVTFTVTMRRRTLY 232

Query: 259 FIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPL 318
           + +N++IPC+L S L  LVF LP DSGEK++L I+VLLSLTVF+L++ E++P+TS +VPL
Sbjct: 233 YGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPL 292

Query: 319 IGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPS 378
           I +Y   TM+ V  S+++TVIV+  HH  P    MP W R + ++      +F  MKRP 
Sbjct: 293 IAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNW---CAWFLRMKRPG 349

Query: 379 REK-------QDKKIFTEDIDISDISGKPGPPP--------MGF---------------- 407
            +K       + ++     +++S ++    PPP        +GF                
Sbjct: 350 EDKVRPACQHKQRRCSLASVEMSAVA----PPPASNGNLLYIGFRGLDGVHCVPTPDSGV 405

Query: 408 ----------HSPLIKH--------PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAM 449
                     H   + H        P++   +E ++YIA   +   ES    +EWK+ A 
Sbjct: 406 VCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAAC 465

Query: 450 VMDHILL---GVFMLVCIIGTL 468
           V+D + L    VF ++C IG L
Sbjct: 466 VVDRLCLMAFSVFTIICTIGIL 487


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  300 bits (768), Expect = 2e-81
 Identities = 183/519 (35%), Positives = 274/519 (52%), Gaps = 80/519 (15%)

Query: 1   MEPWPLLLLFSLCSAGL---VLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQL 57
           M P  LL+L     A L   V GSE E RL  KLF  Y S VRP  +    V V+VGL L
Sbjct: 1   MTPGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLIL 60

Query: 58  IQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDY 117
            QLI+++E ++ ++T V L      DL                   +W DY L W+P ++
Sbjct: 61  AQLISLNEKDEEMSTKVYL------DL-------------------EWTDYRLSWDPAEH 95

Query: 118 GGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIV 177
            G+  + I +E +W PD+VL NN DG+F +     V++   G + W PP I++S C I V
Sbjct: 96  DGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQV 155

Query: 178 THFPFDEQNCSMKLGTWTYDGSVVAINPESDQPD----------LSNFMESGEWVI--KE 225
           T+FPFD QNC+M   +++YD S V++      PD             F+E+G+W I  K 
Sbjct: 156 TYFPFDWQNCTMVFSSYSYDSSEVSLQTGLG-PDGQGHQEIHIHEGTFIENGQWEIIHKP 214

Query: 226 SRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG 285
           SR  +         +    ++ ++ +++R PL+++VNVI PC+L + L   VFYLP D+G
Sbjct: 215 SRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAG 274

Query: 286 EKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHH 345
           EKM LSI  LL+LTVFLL++ + +P TS +VP+I KY++FTMV V  S+I++V+V+N HH
Sbjct: 275 EKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHH 334

Query: 346 RSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPG---- 401
           RSP TH MP WVR++FI  +P    +  +KRP   K ++ +  E    S      G    
Sbjct: 335 RSPHTHQMPLWVRQIFIHKLP---LYLRLKRP---KPERDLMPEPPHCSSPGSGWGRGTD 388

Query: 402 -----PPPMGFHSP------------------------LIKHPEVKSAIEGIKYIAETMK 432
                 PP  F  P                        +   PE++  +  I YIA  ++
Sbjct: 389 EYFIRKPPSDFLFPKPNRFQPELSAPDLRRFIDGPNRAVALLPELREVVSSISYIARQLQ 448

Query: 433 SDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVF 471
             ++ +    +W++VAMV+D + L  F++   +GTL +F
Sbjct: 449 EQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIF 487


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  293 bits (749), Expect = 3e-79
 Identities = 166/484 (34%), Positives = 260/484 (53%), Gaps = 69/484 (14%)

Query: 22  EHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDM 81
           ++  +L   LF+DYS+ +RPVED  +V+ VT+ + L Q+ ++DE NQI+T  + ++Q   
Sbjct: 29  KYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQ--- 85

Query: 82  VDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNA 141
                                  W D  L W+ D Y G+  I IPS+ +WRPD+VLYN A
Sbjct: 86  ----------------------IWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKA 123

Query: 142 DGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVV 201
           D + +    T V+L+Y G ITW  PAI KS C + VT+FPFD Q C++  G+WTY+G+ V
Sbjct: 124 DDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQV 183

Query: 202 AINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIV 261
            I    D  DLS+F+E  EW +      K+ ++Y CC + PY D+T+  +++R   ++IV
Sbjct: 184 DIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSE-PYPDVTFTLLLKRRSSFYIV 242

Query: 262 NVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGK 321
           N++IPC+L SFL  L FYLP  SGEK++L +++LL++TVF L++ E++P+ S  VPLIGK
Sbjct: 243 NLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPA-SENVPLIGK 301

Query: 322 YMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFF---------- 371
           Y + TM  + AS  +T++V+N H        +P+W R V +  +  ++F           
Sbjct: 302 YYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSP 361

Query: 372 -----------------------STMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFH 408
                                  +  K  SR+K   K    D+      G  G  P    
Sbjct: 362 HHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDL------GCQGKNPQEAE 415

Query: 409 SPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTL 468
           S   ++   K     I+YIA+ +K  + +N+  +EWK VA V+D   + +F ++  + T+
Sbjct: 416 SYCAQY---KVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTI 472

Query: 469 AVFA 472
            + A
Sbjct: 473 LIIA 476


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  288 bits (736), Expect = 1e-77
 Identities = 174/514 (33%), Positives = 268/514 (52%), Gaps = 78/514 (15%)

Query: 7   LLLFSLCSAGLVLGS---EHETRLVAKLF--KDYSSVVRPVEDHRQVVEVTVGLQLIQLI 61
           +L   L +A  V GS     E RL+  LF  K Y+  +RPV    + V+V + L L  LI
Sbjct: 5   VLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLI 64

Query: 62  NVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVK 121
           ++ EV + +TTNV ++ G                         W D  LKWN +++G + 
Sbjct: 65  SLKEVEETLTTNVWIEHG-------------------------WTDNRLKWNAEEFGNIS 99

Query: 122 KIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFP 181
            + +P + +W P++VL NN DG F I     VL+ + G + W PPAIF+S C I VT+FP
Sbjct: 100 VLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFP 159

Query: 182 FDEQNCSMKLGTWTYDGSVVAINPESDQP------------DLSNFMESGEWVIKESRGW 229
           FD QNCS+K  +  Y    + ++ + D              D   F E+GEW I   R  
Sbjct: 160 FDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVH-RPA 218

Query: 230 KHSVTYSCCPDTPYL-DITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKM 288
           + +V      D+P   DIT++ +++R PL++I+N+++PC+L SF+  LVFYLP DSGEK 
Sbjct: 219 RVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKT 278

Query: 289 TLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSP 348
           +++ISVLL+ +VFLL+I + +P+TS A+PLIGK++LF MV V   ++I VIV+N H R+P
Sbjct: 279 SVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTP 338

Query: 349 STHVMPNWVRKVFIDTIPNIMFFSTMKRPSRE-----------------KQDKKIF---- 387
           STHV+   V+K+F++T+P ++    M RP+ +                  + ++ F    
Sbjct: 339 STHVLSEGVKKLFLETLPELLH---MSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKS 395

Query: 388 TEDIDISDISGKPG----------PPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQES 437
             D+     S + G          PP     +      E+K A++G  +I   M+     
Sbjct: 396 RSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNY 455

Query: 438 NNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVF 471
           N     W  VA  +D + L V   V ++GT  +F
Sbjct: 456 NEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIF 489


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  280 bits (717), Expect = 2e-75
 Identities = 154/470 (32%), Positives = 248/470 (52%), Gaps = 31/470 (6%)

Query: 6   LLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDE 65
           LLLLF L +  L        +L   LF +Y+S +RPV D  Q + VT+ + L Q+I++DE
Sbjct: 12  LLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDE 71

Query: 66  VNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHI 125
            NQ++T  + ++Q                         +W D  L+W+P+ YGG+  I I
Sbjct: 72  RNQVLTLYLWIRQ-------------------------EWTDAYLRWDPNAYGGLDAIRI 106

Query: 126 PSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQ 185
           PS  +WRPD+VLYN AD        T V+L++ G + W  PAI +S C + V  FPFD Q
Sbjct: 107 PSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQ 166

Query: 186 NCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLD 245
           +C +  G+WT+ G  + + P      L++F+E+ EW +      +  +TY CC + PY D
Sbjct: 167 HCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSE-PYPD 225

Query: 246 ITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVI 305
           +T+  +++R    ++ N+++PC+L S L  L F+LP DSGEK++L ++VLL+LTVF L++
Sbjct: 226 VTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLL 285

Query: 306 VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTI 365
            E +P   S VPLIGKY + TM  V  S  +T++++N H+  PS   +P W R + +  +
Sbjct: 286 AESMPPAES-VPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHL 344

Query: 366 PNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIK 425
              +       P  + +  ++           G  GPP    H P     + ++ +  + 
Sbjct: 345 ARGLCVRERGEPCGQSRPPELSPSP---QSPEGGAGPPAGPCHEPRCLCRQ-EALLHHVA 400

Query: 426 YIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRL 475
            IA T +S + +     +WK +A VMD   L +F  + ++ +L V    L
Sbjct: 401 TIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL 450


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  248 bits (632), Expect = 1e-65
 Identities = 137/374 (36%), Positives = 207/374 (55%), Gaps = 34/374 (9%)

Query: 5   PLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVD 64
           PLLLL  L       G   E RL+A L ++Y   +RP E    VV V++ L L  LI+++
Sbjct: 7   PLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLN 66

Query: 65  EVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIH 124
           E  + +TTNV ++                          QW DY L+W+P DY G+  + 
Sbjct: 67  EREEALTTNVWIEM-------------------------QWCDYRLRWDPRDYEGLWVLR 101

Query: 125 IPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDE 184
           +PS  +WRPD+VL NN DG F +  +  VL+   G I W PPAIF+S C I VT+FPFD 
Sbjct: 102 VPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDW 161

Query: 185 QNCSMKLGTWTYDGSVV--AINPESDQP------DLSNFMESGEWVIKESRGWKHSVTYS 236
           QNCS+   + TY  + +   ++ E  Q       D   F E+GEW I+           +
Sbjct: 162 QNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAA 221

Query: 237 CCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDS-GEKMTLSISVL 295
              +  +  + ++ ++QR PL++++N+I PC+L S +  L+ +LP  + G+K T++I+VL
Sbjct: 222 PAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVL 281

Query: 296 LSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPN 355
           L+ TVFL ++ + +P TS AVPLI KY+ F +V  I  ++  V+V+N   RSP TH M  
Sbjct: 282 LAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMAR 341

Query: 356 WVRKVFIDTIPNIM 369
            VRKVF+  +P ++
Sbjct: 342 GVRKVFLRLLPQLL 355


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  245 bits (626), Expect = 6e-65
 Identities = 147/499 (29%), Positives = 248/499 (49%), Gaps = 55/499 (11%)

Query: 3   PWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLIN 62
           P  +LLL  L   G+  G   E RL   LF +Y    RPV +    V +++ + L  LI+
Sbjct: 5   PLGVLLLLGLLGRGV--GKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLIS 62

Query: 63  VDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKK 122
           ++E  + +TT+V                 +G+          W DY L ++ DD+GG++ 
Sbjct: 63  LNEKEETLTTSV----------------WIGI---------DWQDYRLNYSKDDFGGIET 97

Query: 123 IHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPF 182
           + +PSE +W P++VL NN DG F +     VL+   G +TW PPAI++S C + VT+FPF
Sbjct: 98  LRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPF 157

Query: 183 DEQNCSMKLGTWTYDGSVVAINPESDQP---------DLSNFMESGEWVIKESRGWKHSV 233
           D QNCS+   + TY+   V      D           D   + E+GEW I    G     
Sbjct: 158 DWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRH 217

Query: 234 TYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDS-GEKMTLSI 292
                      D+ Y  +++R PL++++N+I+PC+L S L  L ++LP  + G+K T+SI
Sbjct: 218 HGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSI 277

Query: 293 SVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHV 352
           +VLL+ TVFL +I + IP TS +VPL+G++++F MV     ++  VIV+N   R+P+TH 
Sbjct: 278 NVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHA 337

Query: 353 MPNWVRKVFIDTIPNIM----------FFSTMKRPS-------REKQDKKIFTEDIDISD 395
           M   +R V ++ +P ++            S  +R S        E+   K    ++    
Sbjct: 338 MSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEG 397

Query: 396 ISGKPGPPPMGFHSPL-IKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHI 454
              + G     F   L    PEV+  ++ + ++AE+ +  + +    ++W  +   +D+I
Sbjct: 398 QRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNI 457

Query: 455 LLGVFMLVCIIGTLAVFAG 473
                +++  +G+  +F G
Sbjct: 458 CFWAALVLFSVGSSLIFLG 476


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  225 bits (573), Expect = 8e-59
 Identities = 131/380 (34%), Positives = 201/380 (52%), Gaps = 62/380 (16%)

Query: 141 ADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSV 200
           AD  F     T VL+  +GH  + PP IFKS C I V  FPFD Q+C +K G+W+Y G  
Sbjct: 28  ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGW- 86

Query: 201 VAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFI 260
            +++ +  + D+S ++ +GEW +    G +    Y CC + PY D+T+   M+R  LY+ 
Sbjct: 87  -SLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKE-PYPDVTFTVTMRRRTLYYG 144

Query: 261 VNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIG 320
           +N++IPC+L S L  LVF LP DSGEK++L I+VLLSLTVF+L++ E++P+TS +VPLI 
Sbjct: 145 LNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIA 204

Query: 321 KYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSRE 380
           +Y   TM+ V  S+++TVIV+  HH  P    MP W R + ++      +F  MKRP  +
Sbjct: 205 QYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNW---CAWFLRMKRPGED 261

Query: 381 K-------QDKKIFTEDIDISDISGKPGPPP--------MGF------------------ 407
           K       + ++     +++S ++    PPP        +GF                  
Sbjct: 262 KVRPACQHKQRRCSLASVEMSAVA----PPPASNGNLLYIGFRGLDGVHCVPTPDSGVVC 317

Query: 408 --------HSPLIKH--------PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVM 451
                   H   + H        P++   +E ++YIA   +   ES    +EWK+ A V+
Sbjct: 318 GRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVV 377

Query: 452 DHILL---GVFMLVCIIGTL 468
           D + L    VF ++C IG L
Sbjct: 378 DRLCLMAFSVFTIICTIGIL 397


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  189 bits (479), Expect = 6e-48
 Identities = 126/486 (25%), Positives = 231/486 (47%), Gaps = 63/486 (12%)

Query: 7   LLLFSLCSAGLVLGSEHETR-----LVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLI 61
           LLL +L + G    S + TR     L   L  +Y   VRPV D R+   V++ + +  ++
Sbjct: 18  LLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAIL 77

Query: 62  NVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVK 121
           NVDE NQ++TT +  +Q                          W D  L+WNP+D+  + 
Sbjct: 78  NVDEKNQVLTTYIWYRQ-------------------------YWTDEFLQWNPEDFDNIT 112

Query: 122 KIHIPSEKIWRPDLVLYNNAD-GDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF 180
           K+ IP++ IW PD+++    D G    + +  V +++ G +    P    + C + + +F
Sbjct: 113 KLSIPTDSIWVPDILINEFVDVGKSPNIPY--VYIRHQGEVQNYKPLQVVTACSLDIYNF 170

Query: 181 PFDEQNCSMKLGTWTYDGSVVAIN----PESDQPDLSNFMESGEWVIKESRGWKHSVTYS 236
           PFD QNCS+   +W +    + I+    PE  + D S FM  GEW +     +     +S
Sbjct: 171 PFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFRE--FS 228

Query: 237 CCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLL 296
                 Y ++ ++ V++R PL+++V++++P +    +  + FYLP +SGE+++  I++LL
Sbjct: 229 MESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLL 288

Query: 297 SLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNW 356
             +VFL+++ + +P+T+   PLIG Y +  M  ++ S+  T+ ++   H+      +P W
Sbjct: 289 GYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAW 348

Query: 357 VRKVFIDTIPNIMFF---STMKRPSREKQDKKIFTEDIDI-----------SDISGKP-- 400
           +R + ++ I  ++     ST +RP    Q  K  T+D               D    P  
Sbjct: 349 LRHLVLERIAWLLCLREQSTSQRPPATSQATK--TDDCSAMGNHCSHMGGPQDFEKSPRD 406

Query: 401 --GPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGV 458
              PPP    + L     V   ++ +  I + ++   E    A +W  V  V+D +L  +
Sbjct: 407 RCSPPPPPREASL----AVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHI 462

Query: 459 FMLVCI 464
           ++L  +
Sbjct: 463 YLLAVL 468


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  187 bits (475), Expect = 2e-47
 Identities = 119/462 (25%), Positives = 221/462 (47%), Gaps = 58/462 (12%)

Query: 26  RLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLP 85
           RL   L  +Y   VRPV D R+   V++ + +  ++NVDE NQ++TT +  +Q       
Sbjct: 21  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQ------- 73

Query: 86  RPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNAD-GD 144
                              W D  L+WNP+D+  + K+ IP++ IW PD+++    D G 
Sbjct: 74  ------------------YWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGK 115

Query: 145 FAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAIN 204
              + +  V +++ G +    P    + C + + +FPFD QNCS+   +W +    + I+
Sbjct: 116 SPNIPY--VYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINIS 173

Query: 205 ----PESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFI 260
               PE  + D S FM  GEW +     +     +S      Y ++ ++ V++R PL+++
Sbjct: 174 LWRLPEKVKSDRSVFMNQGEWELLGVLPYFRE--FSMESSNYYAEMKFYVVIRRRPLFYV 231

Query: 261 VNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIG 320
           V++++P +    +  + FYLP +SGE+++  I++LL  +VFL+++ + +P+T+   PLIG
Sbjct: 232 VSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIG 291

Query: 321 KYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFF---STMKRP 377
            Y +  M  ++ S+  T+ ++   H+      +P W+R + ++ I  ++     ST +RP
Sbjct: 292 VYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRP 351

Query: 378 SREKQDKKIFTEDIDI-----------SDISGKP----GPPPMGFHSPLIKHPEVKSAIE 422
               Q  K  T+D               D    P     PPP    + L     V   ++
Sbjct: 352 PATSQATK--TDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASL----AVCGLLQ 405

Query: 423 GIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCI 464
            +  I + ++   E    A +W  V  V+D +L  +++L  +
Sbjct: 406 ELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVL 447


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  175 bits (443), Expect = 9e-44
 Identities = 127/518 (24%), Positives = 232/518 (44%), Gaps = 95/518 (18%)

Query: 7   LLLFSLCSAGLVLGSEHETR-----LVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLI 61
           LLL +L + G    S + TR     L   L  +Y   VRPV D R+   V++ + +  ++
Sbjct: 18  LLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAIL 77

Query: 62  NVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVK 121
           NVDE NQ++TT +  +Q                          W D  L+WNP+D+  + 
Sbjct: 78  NVDEKNQVLTTYIWYRQ-------------------------YWTDEFLQWNPEDFDNIT 112

Query: 122 KIHIPSEKIWRPDLVLYNNAD-GDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF 180
           K+ IP++ IW PD+++    D G    + +  V +++ G +    P    + C + + +F
Sbjct: 113 KLSIPTDSIWVPDILINEFVDVGKSPNIPY--VYIRHQGEVQNYKPLQVVTACSLDIYNF 170

Query: 181 PFDEQNCSMKLGTWTYDGSVVAIN----PESDQPDLSNFMESGEWVIKESRGWKHSVTYS 236
           PFD QNCS+   +W +    + I+    PE  + D S FM  GEW +     +     +S
Sbjct: 171 PFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFRE--FS 228

Query: 237 CCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLL 296
                 Y ++ ++ V++R PL+++V++++P +    +  + FYLP +SGE+++  I++LL
Sbjct: 229 MESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLL 288

Query: 297 SLTVFLLVIVELIPSTSSAVPLIGK--------------------------------YML 324
             +VFL+++ + +P+T+   PLIGK                                Y +
Sbjct: 289 GYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFV 348

Query: 325 FTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFF---STMKRPSREK 381
             M  ++ S+  T+ ++   H+      +P W+R + ++ I  ++     ST +RP    
Sbjct: 349 VCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATS 408

Query: 382 QDKKIFTEDIDI-----------SDISGKP----GPPPMGFHSPLIKHPEVKSAIEGIKY 426
           Q  K  T+D               D    P     PPP    + L     V   ++ +  
Sbjct: 409 QATK--TDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASL----AVCGLLQELSS 462

Query: 427 IAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCI 464
           I + ++   E    A +W  V  V+D +L  +++L  +
Sbjct: 463 IRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVL 500


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  174 bits (440), Expect = 2e-43
 Identities = 103/312 (33%), Positives = 162/312 (51%), Gaps = 60/312 (19%)

Query: 209 QPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCL 268
           + D+S ++ +GEW +    G +    Y CC + PY D+T+   M+R  LY+ +N++IPC+
Sbjct: 3   EADISGYIPNGEWDLVGIPGKRSERFYECCKE-PYPDVTFTVTMRRRTLYYGLNLLIPCV 61

Query: 269 LFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMV 328
           L S L  LVF LP DSGEK++L I+VLLSLTVF+L++ E++P+TS +VPLI +Y   TM+
Sbjct: 62  LISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMI 121

Query: 329 FVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREK------- 381
            V  S+++TVIV+  HH  P    MP W R + ++      +F  MKRP  +K       
Sbjct: 122 IVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNW---CAWFLRMKRPGEDKVRPACQH 178

Query: 382 QDKKIFTEDIDISDISGKPGPPP--------MGF-------------------------- 407
           + ++     +++S ++    PPP        +GF                          
Sbjct: 179 KQRRCSLASVEMSAVA----PPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPT 234

Query: 408 HSPLIKH--------PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILL--- 456
           H   + H        P++   +E ++YIA   +   ES    +EWK+ A V+D + L   
Sbjct: 235 HDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAF 294

Query: 457 GVFMLVCIIGTL 468
            VF ++C IG L
Sbjct: 295 SVFTIICTIGIL 306


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  119 bits (298), Expect = 6e-27
 Identities = 85/376 (22%), Positives = 166/376 (44%), Gaps = 48/376 (12%)

Query: 105 WVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYT---GHI 161
           W +  + WNP++  G+ K+ + ++ +W PD+ +    D D    K  K L  Y    G I
Sbjct: 110 WDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVD----KTPKGLTAYVSNEGRI 165

Query: 162 TWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLS----NFME 217
            +  P    S C + + +FPFD+QNC++   ++ Y    + ++ E +  +++    N ++
Sbjct: 166 RYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQ 225

Query: 218 S-GEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGL 276
           + GEW   E  G   +          Y  I ++  ++R P  +++N+++P      +  L
Sbjct: 226 THGEW---ELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDAL 282

Query: 277 VFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIII 336
            FYLP  SG ++   I++LL   VFLL++ +L+P  +S  PLIG Y    +  ++ S++ 
Sbjct: 283 SFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLP--TSGTPLIGVYFALCLSLMVGSLLE 340

Query: 337 TVIVIN-THHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISD 395
           T+ + +  H  +     +P W+  + +    N         P +E +             
Sbjct: 341 TIFITHLLHVATTQPPPLPRWLHSLLLHC--NSPGRCCPTAPQKENK------------- 385

Query: 396 ISGKPGPPPMGFHSPLIKHPEVKSA----------IEGIKYIAETMKSDQESNNAAAEWK 445
                GP     H P +K PEV +             G ++     + + +  ++   W 
Sbjct: 386 -----GPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWL 440

Query: 446 YVAMVMDHILLGVFML 461
             +  MD +L  +++L
Sbjct: 441 QFSHAMDAMLFRLYLL 456


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  115 bits (289), Expect = 7e-26
 Identities = 87/346 (25%), Positives = 152/346 (43%), Gaps = 43/346 (12%)

Query: 12  LCSAGLVLGSEHETR------LVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDE 65
           L +AG++    H  +      L  +L + Y   VRPV +  +   V + L +  +++VD 
Sbjct: 14  LVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDA 73

Query: 66  VNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHI 125
            NQI+ T+V  +                         E W D  L WN   +  +++I +
Sbjct: 74  ENQILKTSVWYQ-------------------------EVWNDEFLSWNSSMFDEIREISL 108

Query: 126 PSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQ 185
           P   IW PD+++    D +        V +  +G I    P    S C +    FPFD Q
Sbjct: 109 PLSAIWAPDIIINEFVDIE-RYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQ 167

Query: 186 NCSMKLGTWTYDGSVVAI----NPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDT 241
           NCS+   +  +    V +    +PE  Q D   F+   EW +        S TYS    +
Sbjct: 168 NCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSV-----SSTYSILQSS 222

Query: 242 P--YLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLT 299
              +  I ++ VM+R PL ++V+++IP +    +    FYLP +   ++    SVL+  T
Sbjct: 223 AGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYT 282

Query: 300 VFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHH 345
           VF + +   +P +  + PLIG +    M F++ S+  +++++   H
Sbjct: 283 VFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLH 328


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  112 bits (281), Expect = 6e-25
 Identities = 66/264 (25%), Positives = 124/264 (46%), Gaps = 12/264 (4%)

Query: 105 WVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWT 164
           W +  + WNP +  G+ K+ + +E +W PD+ +  + D D      T   +   G I + 
Sbjct: 95  WDNPFINWNPKECVGINKLTVLAENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYD 153

Query: 165 PPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSN-----FMESG 219
            P    S C + + +FPFD+QNC+    ++ Y    + +  + +  ++++         G
Sbjct: 154 KPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQG 213

Query: 220 EWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFY 279
           EW   E  G   +       +  Y  I ++  ++R P  +I+N+++P      +  L FY
Sbjct: 214 EW---ELLGINKATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFY 270

Query: 280 LPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITV- 338
           LP +S  +    I++LL   VFLL++ +L+P  +S  PLI  Y    +  ++ S++ TV 
Sbjct: 271 LPAESENRAPFKITLLLGYNVFLLMMNDLLP--ASGTPLISVYFALCLSLMVVSLLETVF 328

Query: 339 IVINTHHRSPSTHVMPNWVRKVFI 362
           I    H  +     MP W+  + +
Sbjct: 329 ITYLLHVATTQPPPMPRWLHSLLL 352


>gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1
           [Homo sapiens]
          Length = 404

 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 87/404 (21%), Positives = 154/404 (38%), Gaps = 78/404 (19%)

Query: 98  SHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNAD-------GDFAIVKF 150
           SHLQ      +   WNPD+ GG+KK  + +E +W  D+ +  + D          +IVK 
Sbjct: 24  SHLQLVTSFLWLNMWNPDECGGIKKSGMATENLWLSDVFIEESVDQTPAGLMASMSIVKA 83

Query: 151 TKVLLQYTG---HITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGT-----WTYDGSVVA 202
           T   +   G      WTP          I       E++ S    T     W        
Sbjct: 84  TSNTISQCGWSASANWTPS---------ISPSMDRGERSPSALSPTQVTRAWRRMSRSFQ 134

Query: 203 INPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRL--PLYFI 260
           I+  +      +F    EWV+   +     VT +      Y    +H  ++R   P  ++
Sbjct: 135 IHHRT------SFRTRREWVLLGIQKRTIKVTVAT---NQYEQAIFHVAIRRRCRPSPYV 185

Query: 261 VNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIP--STSSAVPL 318
           VN ++P  +   +  L FYLP +SG      ++VLL  +VFLL++ +L+P  STSS   L
Sbjct: 186 VNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASL 245

Query: 319 I----------GKYMLFTMVFVIASIIITVIVINTHHRSPSTHV-MPNWVRKVFIDTIPN 367
           +          G Y    +  ++ S++ T+ + +  H + +  + +P W+  + +     
Sbjct: 246 VRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQ 305

Query: 368 IMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA------- 420
                T  +                     G  GP     H P +K PEV +        
Sbjct: 306 GRCCPTAPQ--------------------KGNKGPGLTPTHLPGVKEPEVSAGQMPGPGE 345

Query: 421 ---IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFML 461
                G ++     + + +  ++   W   +  MD +L  +++L
Sbjct: 346 AELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLL 389


>gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]
          Length = 452

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 55/239 (23%), Positives = 114/239 (47%), Gaps = 11/239 (4%)

Query: 103 EQWVDYNLKWN--PDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYT-- 158
           +QW D  L ++  PDD   +    + S  IW+PDL   N    +F  V     LL+ +  
Sbjct: 100 QQWNDSRLAYSEYPDDSLDLDPSMLDS--IWKPDLFFANEKGANFHDVTTDNKLLRISKN 157

Query: 159 GHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQP-DLSNFME 217
           G + ++        C + + +FP D Q C+M+L ++ Y  + +     SD P  ++  + 
Sbjct: 158 GKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLT 217

Query: 218 SGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLV 277
             ++++KE +   +   +        +++ +H  ++R   Y+++ + IP LL   L+ + 
Sbjct: 218 LPQFILKEEKELGYCTKHYNTGKFTCIEVKFH--LERQMGYYLIQMYIPSLLIVILSWVS 275

Query: 278 FYLPTDSG-EKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASII 335
           F++  D+   ++ L I+ +L++T         +P   S V  I  +M   ++FV A+++
Sbjct: 276 FWINMDAAPARVALGITTVLTMTTQSSGSRASLPKV-SYVKAIDIWMAVCLLFVFAALL 333


>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 55/239 (23%), Positives = 114/239 (47%), Gaps = 11/239 (4%)

Query: 103 EQWVDYNLKWN--PDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYT-- 158
           +QW D  L ++  PDD   +    + S  IW+PDL   N    +F  V     LL+ +  
Sbjct: 100 QQWNDSRLAYSEYPDDSLDLDPSMLDS--IWKPDLFFANEKGANFHDVTTDNKLLRISKN 157

Query: 159 GHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQP-DLSNFME 217
           G + ++        C + + +FP D Q C+M+L ++ Y  + +     SD P  ++  + 
Sbjct: 158 GKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLT 217

Query: 218 SGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLV 277
             ++++KE +   +   +        +++ +H  ++R   Y+++ + IP LL   L+ + 
Sbjct: 218 LPQFILKEEKELGYCTKHYNTGKFTCIEVKFH--LERQMGYYLIQMYIPSLLIVILSWVS 275

Query: 278 FYLPTDSG-EKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASII 335
           F++  D+   ++ L I+ +L++T         +P   S V  I  +M   ++FV A+++
Sbjct: 276 FWINMDAAPARVALGITTVLTMTTQSSGSRASLPKV-SYVKAIDIWMAVCLLFVFAALL 333


>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 55/239 (23%), Positives = 114/239 (47%), Gaps = 11/239 (4%)

Query: 103 EQWVDYNLKWN--PDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYT-- 158
           +QW D  L ++  PDD   +    + S  IW+PDL   N    +F  V     LL+ +  
Sbjct: 100 QQWNDSRLAYSEYPDDSLDLDPSMLDS--IWKPDLFFANEKGANFHDVTTDNKLLRISKN 157

Query: 159 GHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQP-DLSNFME 217
           G + ++        C + + +FP D Q C+M+L ++ Y  + +     SD P  ++  + 
Sbjct: 158 GKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLT 217

Query: 218 SGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLV 277
             ++++KE +   +   +        +++ +H  ++R   Y+++ + IP LL   L+ + 
Sbjct: 218 LPQFILKEEKELGYCTKHYNTGKFTCIEVKFH--LERQMGYYLIQMYIPSLLIVILSWVS 275

Query: 278 FYLPTDSG-EKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASII 335
           F++  D+   ++ L I+ +L++T         +P   S V  I  +M   ++FV A+++
Sbjct: 276 FWINMDAAPARVALGITTVLTMTTQSSGSRASLPKV-SYVKAIDIWMAVCLLFVFAALL 333


>gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]
          Length = 449

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 51/239 (21%), Positives = 114/239 (47%), Gaps = 11/239 (4%)

Query: 103 EQWVDYNLKWN--PDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQY--T 158
           ++W D  L ++  PDD   +    + S  IW+PDL   N    +F  V     LL+    
Sbjct: 99  QKWNDPRLAYSEYPDDSLDLDPSMLDS--IWKPDLFFANEKGANFHEVTTDNKLLRIFKN 156

Query: 159 GHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQP-DLSNFME 217
           G++ ++        C + + +FP D Q C M+L ++ Y  + +    + + P  ++  + 
Sbjct: 157 GNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLT 216

Query: 218 SGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLV 277
             ++++KE +  ++   +        +++ +H  ++R   Y+++ + IP LL   L+ + 
Sbjct: 217 LPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFH--LERQMGYYLIQMYIPSLLIVILSWVS 274

Query: 278 FYLPTDSG-EKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASII 335
           F++  D+   ++ L I+ +L++T         +P   S V  I  +M   ++FV ++++
Sbjct: 275 FWINMDAAPARVALGITTVLTMTTQSSGSRASLPKV-SYVKAIDIWMAVCLLFVFSALL 332


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.430 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,751,598
Number of Sequences: 37866
Number of extensions: 850380
Number of successful extensions: 2101
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 1940
Number of HSP's gapped (non-prelim): 89
length of query: 482
length of database: 18,247,518
effective HSP length: 106
effective length of query: 376
effective length of database: 14,233,722
effective search space: 5351879472
effective search space used: 5351879472
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.