Search of human proteins with 7949031

Search of human proteins with 7949031

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide
6 [Homo sapiens]
         (491 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   992   0.0  
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   549   e-156
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   530   e-150
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   527   e-150
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   503   e-142
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   496   e-140
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   496   e-140
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   490   e-138
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   490   e-138
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   479   e-135
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   464   e-131
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   435   e-122
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   406   e-113
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   382   e-106
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   343   2e-94
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   318   9e-87
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   306   2e-83
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   293   2e-79
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   290   2e-78
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   241   1e-63
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   233   3e-61
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   204   1e-52
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  182   5e-46
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   161   1e-39
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   140   3e-33
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   127   2e-29
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   126   5e-29
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   124   1e-28
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   122   6e-28
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   120   4e-27

>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  992 bits (2565), Expect = 0.0
 Identities = 491/491 (100%), Positives = 491/491 (100%)

Query: 1   MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE 60
           MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE
Sbjct: 1   MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE 60

Query: 61  KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR 120
           KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR
Sbjct: 61  KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR 120

Query: 121 WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC 180
           WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC
Sbjct: 121 WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC 180

Query: 181 SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE 240
           SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE
Sbjct: 181 SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE 240

Query: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300
           INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT
Sbjct: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300

Query: 301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360
           ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS
Sbjct: 301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360

Query: 361 DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420
           DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL
Sbjct: 361 DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420

Query: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI 480
           KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI
Sbjct: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI 480

Query: 481 PPTYQIRFLPR 491
           PPTYQIRFLPR
Sbjct: 481 PPTYQIRFLPR 491


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  549 bits (1414), Expect = e-156
 Identities = 261/489 (53%), Positives = 354/489 (72%)

Query: 3   LSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKY 62
           L ++  LA LT ++L+ V R   +  +LPPGP PLP +GN LQ++   +  S ++  E+Y
Sbjct: 6   LLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERY 65

Query: 63  GDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWK 122
           G VFT+HLGPR VV+LCG +A++EALVD+AE FSGRG+ A  D  F+GYGV F+NG R K
Sbjct: 66  GPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAK 125

Query: 123 VLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSI 182
            LRRFS+ T+R FG+GKR +EERIQEEA  LI+ LR + GA +DPTF      +N+I SI
Sbjct: 126 QLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSI 185

Query: 183 VFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEIN 242
           VFG RF Y+D+EFL +L +   +F   ++  GQL+E+FS  +K+ PG  +Q +K LQ + 
Sbjct: 186 VFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLE 245

Query: 243 AYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTET 302
            +I   VE ++ TLDP++P+D ID++L+ M++E+ N ++EF  +NL + TL+LFFAGTET
Sbjct: 246 DFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTET 305

Query: 303 TSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDL 362
            STTLRYGFLL++K+P V  +V+ EI++VIG +R P+  DRAKMPYTEAVI+EIQRF D+
Sbjct: 306 VSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDM 365

Query: 363 LPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK 422
           LPMG+ H V + T FR + +PK TEVF +L + L DP +F  P  FNP HFLD  G  KK
Sbjct: 366 LPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKK 425

Query: 423 TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPP 482
           ++AF+PFS+GKR C GEG+AR ELFLFFTTI+QNF   SP +P+DID++P+  G   IP 
Sbjct: 426 SDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPR 485

Query: 483 TYQIRFLPR 491
            Y + FLPR
Sbjct: 486 NYTMSFLPR 494


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  530 bits (1365), Expect = e-150
 Identities = 253/489 (51%), Positives = 350/489 (71%)

Query: 3   LSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKY 62
           L ++  LA LT ++L+ V +   +  +LPPGP PLP +GN LQ++   +  S ++F E Y
Sbjct: 6   LLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECY 65

Query: 63  GDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWK 122
           G VFT+HLGPR VV+LCG +A+REALVD+AE FSGRG+ A  D  F+GYGV F+NG R K
Sbjct: 66  GPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAK 125

Query: 123 VLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSI 182
            L RF++ T+RDFG+GKR +EERIQEE+  LIE +R + GA +DPTF      +N+I SI
Sbjct: 126 QLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSI 185

Query: 183 VFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEIN 242
           VFG RF Y+D+EFL +L++    F   S+  GQL+E+FS  +K+ PG  +Q +K LQ + 
Sbjct: 186 VFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLE 245

Query: 243 AYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTET 302
            +I   VE ++ TLDP++P+D ID++L+HM++E+ N ++EF  +NL ++TL+LF AGTET
Sbjct: 246 DFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTET 305

Query: 303 TSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDL 362
            STTLRYGFLL++K+P V  +V+ EI++VIG +R P+  DR KMPY EAVI+EIQRF D+
Sbjct: 306 VSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDV 365

Query: 363 LPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK 422
           +PM +   V + T FR + +PK TEVF +L + L DP +F  P  FNP HFLD  G  KK
Sbjct: 366 IPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKK 425

Query: 423 TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPP 482
           ++AF+PFS+GKR C GEG+AR ELFLFFTT++QNF + S  +P+DID++P+      IP 
Sbjct: 426 SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPR 485

Query: 483 TYQIRFLPR 491
            Y + FLPR
Sbjct: 486 NYTMSFLPR 494


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  527 bits (1358), Expect = e-150
 Identities = 250/487 (51%), Positives = 348/487 (71%)

Query: 5   VLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGD 64
           ++  L  LT ++L+ V +   +  +LPPGP PLP +GN LQ++   +  S ++  E+YG 
Sbjct: 8   LVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGP 67

Query: 65  VFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVL 124
           VFT+HLGPR VV+LCG +A+REALVD+AE FSGRG+ A  D  F+GYGV+F+NG R K L
Sbjct: 68  VFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQL 127

Query: 125 RRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVF 184
           RRFS+ T+RDFG+GKR +EERIQEEA  LI+ LR + GA +DPTF      +N+I SIVF
Sbjct: 128 RRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVF 187

Query: 185 GKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAY 244
           G RF Y+D+EFL +L +    F   S+  GQL+E+FS  +K+ PG  +Q ++ LQ +  +
Sbjct: 188 GDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDF 247

Query: 245 IGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTS 304
           I   VE ++ TLDP++P+D ID++L+ M++E+ N ++EF  +NL + TL+LF  GTET S
Sbjct: 248 IAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVS 307

Query: 305 TTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLP 364
           TTLRYGFLL++K+P V  +V+ EI++VIG +R P+  DRAKMPY EAVI+EIQRF D++P
Sbjct: 308 TTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIP 367

Query: 365 MGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTE 424
           M +   V + T FR + +PK TEV+ +L + L DP +F  P  FNP HFL+  G  KK++
Sbjct: 368 MSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSD 427

Query: 425 AFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTY 484
           AF+PFS+GKR C GEG+AR ELFLFFTT++QNF + S  +P+DID++P+  G   IP  Y
Sbjct: 428 AFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNY 487

Query: 485 QIRFLPR 491
            + FLPR
Sbjct: 488 TMSFLPR 494


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  503 bits (1296), Expect = e-142
 Identities = 247/490 (50%), Positives = 338/490 (68%), Gaps = 1/490 (0%)

Query: 1   MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE 60
           ME  V+L L L + +LL  + R      +LPPGP PLP++GN+LQ+D + + KSF  F +
Sbjct: 1   MEPFVVLVLCL-SFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSK 59

Query: 61  KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR 120
            YG VFTV+ G  P+V+  G EA++EAL+D  E FSGRG   +     +G G+I +NG R
Sbjct: 60  VYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKR 119

Query: 121 WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC 180
           WK +RRFS+TT+R+FGMGKRS+E+R+QEEA CL+EELRK+K +  DPTF+      N+IC
Sbjct: 120 WKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVIC 179

Query: 181 SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE 240
           S+VF KRF Y+DQ FL ++  F + F +++S + Q+   F   +  FPG H +V KN+  
Sbjct: 180 SVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVAL 239

Query: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300
             +YI   V++H+ +LD + P+D ID +L+ ME+EK N  SEF+ +NL      LF AGT
Sbjct: 240 TRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGT 299

Query: 301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360
           ETTSTTLRYG LL+LK+P V  +V  EI+ VIG HR P + DR+ MPYT+AV++EIQR+S
Sbjct: 300 ETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYS 359

Query: 361 DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420
           DL+P GVPH VT  T FR Y+IPK T +  +L++ LHD   F  P+ F+P HFLD NG  
Sbjct: 360 DLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNF 419

Query: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI 480
           KK++ F+PFS GKRIC GEG+AR ELFLF TTILQNF++ S    ++++ T    G+  +
Sbjct: 420 KKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSL 479

Query: 481 PPTYQIRFLP 490
           PP+YQI F+P
Sbjct: 480 PPSYQICFIP 489


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  496 bits (1277), Expect = e-140
 Identities = 235/490 (47%), Positives = 339/490 (69%), Gaps = 1/490 (0%)

Query: 1   MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE 60
           M+ +V L L L + L LL + R  +   RLP GP PLP++GN+LQ+D + + KS   F +
Sbjct: 1   MDPAVALVLCL-SCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSK 59

Query: 61  KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR 120
            YG VFTV+ G +P+V+L G EA++EAL+D  E FSGRG   + +   +G G++F+NG R
Sbjct: 60  VYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKR 119

Query: 121 WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC 180
           WK +RRF + T+R+FGMGKRS+E+R+QEEA+CL+EELRK+  +  DPTF+      N+IC
Sbjct: 120 WKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVIC 179

Query: 181 SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE 240
           S++F  RF Y+DQ FL ++  F +   ++SS + Q+   F   + Y PG+H ++ +N   
Sbjct: 180 SVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAY 239

Query: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300
           I +Y+   +++H+E+LD ++ +D ID +L+ ME+EK N  SEF+ ++L      +F AGT
Sbjct: 240 IKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGT 299

Query: 301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360
           ETTSTTLRYG LL+LKYP V  +V  EIE V+G +R P + DR+ MPYT+AV++EIQR+ 
Sbjct: 300 ETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYI 359

Query: 361 DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420
           DLLP  +PH VT    F+ Y+IPK T +   L++ LH+   F  P+ F+P HFLD +G  
Sbjct: 360 DLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNF 419

Query: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI 480
           KK++ F+PFS GKR+C+GEG+AR ELFLF TTILQNF++ S V P+DID+TP     G++
Sbjct: 420 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRV 479

Query: 481 PPTYQIRFLP 490
           PP YQ+ F+P
Sbjct: 480 PPLYQLCFIP 489


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  496 bits (1276), Expect = e-140
 Identities = 235/487 (48%), Positives = 341/487 (70%)

Query: 4   SVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYG 63
           S+++ +  L+ LLLL + R  +   +LPPGP PLP++GN+LQ+  + + KS     + YG
Sbjct: 3   SLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYG 62

Query: 64  DVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKV 123
            VFT++ G +P+V+L G EA++EAL+D  E FSGRG   + +   RG+G++F+NG +WK 
Sbjct: 63  PVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKE 122

Query: 124 LRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIV 183
           +RRFS+ T+R+FGMGKRS+E+R+QEEA+CL+EELRK+K +  DPTF+      N+ICSI+
Sbjct: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182

Query: 184 FGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINA 243
           F KRF Y+DQ+FL ++    +   ++SS + Q+   FS  + YFPG H ++ KN+  + +
Sbjct: 183 FHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKS 242

Query: 244 YIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETT 303
           YI   V++H+E++D + P+D ID +L+ MEKEK N  SEF+ ++L    + LF AGTETT
Sbjct: 243 YILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETT 302

Query: 304 STTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLL 363
           STTLRY  LL+LK+P V  +V  EIE+VIG +R P + DR+ MPYT+AV++E+QR+ DLL
Sbjct: 303 STTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLL 362

Query: 364 PMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKT 423
           P  +PH VT    FR Y+IPK T + + L++ LHD   F  P+ F+P HFLD  G  KK+
Sbjct: 363 PTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 422

Query: 424 EAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPT 483
           + F+PFS GKRIC+GE +A  ELFLF T+ILQNF++ S V P+++D TP   G   +PP 
Sbjct: 423 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPF 482

Query: 484 YQIRFLP 490
           YQ+ F+P
Sbjct: 483 YQLCFIP 489


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  490 bits (1261), Expect = e-138
 Identities = 237/490 (48%), Positives = 335/490 (68%), Gaps = 1/490 (0%)

Query: 1   MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE 60
           M+  V+L L L + LLLL + R  +   +LPPGP PLP++GN+LQ+D + + KS     +
Sbjct: 1   MDPFVVLVLCL-SCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSK 59

Query: 61  KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR 120
            YG VFT++ G   +V+L G E ++EAL+D  E FSGRG   + +   RG+G++F+NG R
Sbjct: 60  IYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKR 119

Query: 121 WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC 180
           WK +RRFS+ T+R+FGMGKRS+E+R+QEEA+CL+EELRK+K +  DPTF+      N+IC
Sbjct: 120 WKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVIC 179

Query: 181 SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE 240
           SI+F KRF Y+DQ+FL ++    +   ++S+ + Q+   F   + YFPG H ++ KNL  
Sbjct: 180 SIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAF 239

Query: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300
           + + I   V++H+E++D + P+D ID +L+ MEKEK N  SEF+ +NL +    L  AGT
Sbjct: 240 MESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGT 299

Query: 301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360
           ETTSTTLRY  LL+LK+P V  +V  EIE+VIG +R P + DR  MPYT+AV++E+QR+ 
Sbjct: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYI 359

Query: 361 DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420
           DL+P  +PH VT    FR Y+IPK T +   L++ LHD   F  P+ F+P HFLD  G  
Sbjct: 360 DLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNF 419

Query: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI 480
           KK+  F+PFS GKRIC+GEG+AR ELFLF T ILQNF++ S + P+D+D TP   G   +
Sbjct: 420 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASV 479

Query: 481 PPTYQIRFLP 490
           PP YQ+ F+P
Sbjct: 480 PPFYQLCFIP 489


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  490 bits (1261), Expect = e-138
 Identities = 238/488 (48%), Positives = 334/488 (68%), Gaps = 3/488 (0%)

Query: 4   SVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYG 63
           ++LL L  L  LLL L  R      +LPPGPRPL +LGNLL +  + +L S  +  ++YG
Sbjct: 7   AILLLLLALVCLLLTLSSRDKG---KLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYG 63

Query: 64  DVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKV 123
            ++TVHLGPR VV+L G +A++EALVD+ E FSGRG       F +G G+ F++G+RWKV
Sbjct: 64  SMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKV 123

Query: 124 LRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIV 183
           LR+FS+  +R+FGMGKRS+EERI EE   L+ ELRK++G   DPTF+     +NIICS++
Sbjct: 124 LRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVL 183

Query: 184 FGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINA 243
           FG RF Y D+  L ++ L    F ++SS +G+L+++F   L + PG H+++++N + +  
Sbjct: 184 FGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRD 243

Query: 244 YIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETT 303
            I HSV  H+ +LDP +P+D I  +L  M +EK +  S F    L + T +L F GT+T 
Sbjct: 244 LIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTV 303

Query: 304 STTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLL 363
           STTL + FL ++KYP V  RV  EI+ V+G  R P L DRA MPYT+AVI+E+QRF+D++
Sbjct: 304 STTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADII 363

Query: 364 PMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKT 423
           PM +PH VT+ T+FRG++IPK T+V  +L+T  +DP  F  P  FNP+HFLDAN + KK+
Sbjct: 364 PMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKS 423

Query: 424 EAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPT 483
            AF+PFS G+R+CLGE +AR ELFL+ T ILQ+FS+    APEDIDLTP   G+G +P  
Sbjct: 424 PAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRP 483

Query: 484 YQIRFLPR 491
           +Q+   PR
Sbjct: 484 FQLCLRPR 491


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  479 bits (1233), Expect = e-135
 Identities = 238/489 (48%), Positives = 335/489 (68%), Gaps = 4/489 (0%)

Query: 4   SVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYG 63
           ++LL LALL  LLL L          LPPGP PLPLLGNLLQ+    L    +R  +KYG
Sbjct: 8   ALLLALALL--LLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYG 65

Query: 64  DVFTVHLGP-RPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWK 122
            VFT++LGP RPVV+L G EA+REAL  +AE FSGRG +AM++  F G+GV F+NG RW+
Sbjct: 66  PVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWR 125

Query: 123 VLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSI 182
            LR+F++  +RD GMGKR  EE IQ EA+CL+E  + ++G   DP+ L    T+N++CS+
Sbjct: 126 QLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSL 185

Query: 183 VFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEIN 242
           +FG RF Y+D+EF  ++     T   +SS  GQ +E+FS FL+  PG H+Q+  ++  + 
Sbjct: 186 LFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLA 245

Query: 243 AYIGHSVEKHRETLDPSAP-KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTE 301
           A+    V++H+  LD S P +DL+D +LL M +E+ N  +EF+++N+ +  + L FAGT 
Sbjct: 246 AFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTM 305

Query: 302 TTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSD 361
           T STT+ Y  LL++KYPHV + V  E+ + +G  + P L DR ++PYT+AV++E QR   
Sbjct: 306 TVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLA 365

Query: 362 LLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALK 421
           L+PMG+P  + + T FRGY +P+ TEVF +L + LHDP+ F+ P+ FNPD FLDA+G  +
Sbjct: 366 LVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFR 425

Query: 422 KTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIP 481
           K EAF+PFSLGKR+CLGEG+A+AELFLFFTTILQ FS+ SP  P+ + L P   G+  IP
Sbjct: 426 KHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIP 485

Query: 482 PTYQIRFLP 490
           P +Q++  P
Sbjct: 486 PAFQLQVRP 494


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  464 bits (1195), Expect = e-131
 Identities = 224/477 (46%), Positives = 324/477 (67%), Gaps = 1/477 (0%)

Query: 15  LLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRP 74
           LLL+ + R  ++   LPPGP PLP++GNL Q++ + + KSF R  +++G VFT+++G + 
Sbjct: 17  LLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQR 76

Query: 75  VVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRD 134
           +V++ G +A++EAL+D  + FSGRG +       R  G+IF NG  WK +RRFS+TT+R+
Sbjct: 77  MVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAH-RDRGIIFNNGPTWKDIRRFSLTTLRN 135

Query: 135 FGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQE 194
           +GMGK+  E RIQ EA  L+E LRK++G   DPTFL      N+I  I+F K F Y D++
Sbjct: 136 YGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEK 195

Query: 195 FLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRE 254
           FL+++ LF + F L+S+ + QL+  F  FL Y PG+HR+V KN+ E+  Y+   V++H +
Sbjct: 196 FLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQ 255

Query: 255 TLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLM 314
           +LDP+ P+DL D  L+ MEKEK +A   ++   + +    LFFAGTETTSTTLRYG L++
Sbjct: 256 SLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLIL 315

Query: 315 LKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQH 374
           +KYP + E+++ EI++VIGP R P + DR +MPY +AV++EIQRF  L+P  +PH  T+ 
Sbjct: 316 MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRD 375

Query: 375 TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR 434
           T FRGY+IPK T V   L + L+D   F  P+ F P+HFL+ NG  K ++ F PFS GKR
Sbjct: 376 TIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKR 435

Query: 435 ICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491
           +C GEG+AR ELFL    ILQ+F++   V P+DIDL+P   G G IPP Y++  +PR
Sbjct: 436 VCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  435 bits (1118), Expect = e-122
 Identities = 217/489 (44%), Positives = 308/489 (62%), Gaps = 51/489 (10%)

Query: 3   LSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKY 62
           L ++  LA LT ++L+ V +   +  +LPPGP PLP +GN LQ++   +  S ++  +  
Sbjct: 6   LLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ-- 63

Query: 63  GDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWK 122
                                                            GV F+NG R K
Sbjct: 64  -------------------------------------------------GVAFSNGERAK 74

Query: 123 VLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSI 182
            L RF++ T+RDFG+GKR +EERIQEE+  LIE +R + GA +DPTF      +N+I SI
Sbjct: 75  QLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSI 134

Query: 183 VFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEIN 242
           VFG RF Y+D+EFL +L++    F   S+  GQL+E+FS  +K+ PG  +Q +K LQ + 
Sbjct: 135 VFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLE 194

Query: 243 AYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTET 302
            +I   VE ++ TLDP++P+D ID++L+HM++E+ N ++EF  +NL ++TL+LF AGTET
Sbjct: 195 DFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTET 254

Query: 303 TSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDL 362
            STTLRYGFLL++K+P V  +V+ EI++VIG +R P+  DR KMPY EAVI+EIQRF D+
Sbjct: 255 VSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDV 314

Query: 363 LPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK 422
           +PM +   V + T FR + +PK TEVF +L + L DP +F  P  FNP HFLD  G  KK
Sbjct: 315 IPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKK 374

Query: 423 TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPP 482
           ++AF+PFS+GKR C GEG+AR ELFLFFTT++QNF + S  +P+DID++P+      IP 
Sbjct: 375 SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPR 434

Query: 483 TYQIRFLPR 491
            Y + FLPR
Sbjct: 435 NYTMSFLPR 443


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  406 bits (1043), Expect = e-113
 Identities = 213/490 (43%), Positives = 294/490 (60%), Gaps = 60/490 (12%)

Query: 1   MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE 60
           M+ +V L L L + L LL + R  +   RLP GP PLP++GN+LQ+D + + KS   F +
Sbjct: 1   MDPAVALVLCL-SCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSK 59

Query: 61  KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR 120
            YG VFTV+ G +P+V+L G EA++EAL+D  E FSGRG   + +   +G G++F+NG R
Sbjct: 60  VYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKR 119

Query: 121 WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC 180
           WK +RRF + T+R+FGMGKRS+E+R+QEEA+CL+EELRK+  +  DPTF+      N+IC
Sbjct: 120 WKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVIC 179

Query: 181 SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE 240
           S++                  F+  F      F  L E F+  L+       Q       
Sbjct: 180 SVI------------------FHDRFDYKDQRFLNLMEKFNENLRILSSPWIQ------- 214

Query: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300
                                             EK N  SEF+ ++L      +F AGT
Sbjct: 215 ----------------------------------EKHNQQSEFTVESLIATVTDMFGAGT 240

Query: 301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360
           ETTSTTLRYG LL+LKYP V  +V  EIE V+G +R P + DR+ MPYT+AV++EIQR+ 
Sbjct: 241 ETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYI 300

Query: 361 DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420
           DLLP  +PH VT    F+ Y+IPK T +   L++ LH+   F  P+ F+P HFLD +G  
Sbjct: 301 DLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNF 360

Query: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI 480
           KK++ F+PFS GKR+C+GEG+AR ELFLF TTILQNF++ S V P+DID+TP     G++
Sbjct: 361 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRV 420

Query: 481 PPTYQIRFLP 490
           PP YQ+ F+P
Sbjct: 421 PPLYQLCFIP 430


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  382 bits (982), Expect = e-106
 Identities = 193/444 (43%), Positives = 275/444 (61%), Gaps = 4/444 (0%)

Query: 19  LVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVML 78
           L +R P  +   PPGP  LP LGN   +D          F +KYG++F++ LG    V++
Sbjct: 35  LKRRRPKNY---PPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLI 91

Query: 79  CGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMG 138
            G+  I+EAL+   + F  R    M +  F+  G+I ++G  WK  RRF++T +R+FG+G
Sbjct: 92  TGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLG 151

Query: 139 KRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKM 198
           K+S+EERIQEEAQ L E +++  G   DP F   +  +NIICSI FG+RF YQD  F ++
Sbjct: 152 KKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQL 211

Query: 199 LNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDP 258
           L L  +   L +S   QL+ +F   +K+ PG H+ ++ N +++  ++ H ++KHR+  +P
Sbjct: 212 LKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNP 271

Query: 259 SAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYP 318
           +  +D ID YL  M K   N  S F  +NL  +TL LFFAGTETTSTTLR+  L M  YP
Sbjct: 272 AETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYP 331

Query: 319 HVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR 378
            + E+V  EI++VIG  + P    R  MPYT AVI+E+QR  +++P+ VP  VT  T+  
Sbjct: 332 EIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLA 391

Query: 379 GYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLG 438
           GY +PK T +   L+    DP  +  PD FNPDHFL+ NG  KK EAF+PFS+GKR CLG
Sbjct: 392 GYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE-NGQFKKREAFMPFSIGKRACLG 450

Query: 439 EGIARAELFLFFTTILQNFSMASP 462
           E +AR ELF+FFT+++Q F+   P
Sbjct: 451 EQLARTELFIFFTSLMQKFTFRPP 474


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  343 bits (880), Expect = 2e-94
 Identities = 202/502 (40%), Positives = 284/502 (56%), Gaps = 16/502 (3%)

Query: 1   MELSVLLFLALLTGLLLLLVQ---RHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLR 57
           M L  L+ LA++  + LLLV    R      R PPGP PLP LGNLL +D +     F +
Sbjct: 1   MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60

Query: 58  FREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFF---RGYGVI 114
            R ++GDVF++ L   PVV+L G+ A+REALV   E  + R  + +        R  GV 
Sbjct: 61  LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120

Query: 115 FAN-GNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQS 173
            A  G  W+  RRFSV+T+R+ G+GK+S+E+ + EEA CL        G    P  L   
Sbjct: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180

Query: 174 ITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQ 233
             +N+I S+  G+RF Y D  FL++L+L  +     S    ++       L + P    +
Sbjct: 181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL-HIPALAGK 239

Query: 234 VYKNLQEINAYIGHSVEKHRETLDPSAP-KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNT 292
           V +  +     +   + +HR T DP+ P +DL + +L  MEK K N  S F+ +NL +  
Sbjct: 240 VLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVV 299

Query: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAV 352
             LF AG  TTSTTL +G LLM+ +P V  RV +EI+ VIG  R PE+ D+A MPYT AV
Sbjct: 300 ADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAV 359

Query: 353 IYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDH 412
           I+E+QRF D++P+GV H+ ++    +G+ IPK T +   LS+ L D   +EKP  F+P+H
Sbjct: 360 IHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEH 419

Query: 413 FLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTP 472
           FLDA G   K EAF+PFS G+R CLGE +AR ELFLFFT++LQ+FS + P         P
Sbjct: 420 FLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQP----RP 475

Query: 473 QECGVGKI---PPTYQIRFLPR 491
              GV      P  Y++  +PR
Sbjct: 476 SHHGVFAFLVTPSPYELCAVPR 497


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  318 bits (814), Expect = 9e-87
 Identities = 186/478 (38%), Positives = 275/478 (57%), Gaps = 13/478 (2%)

Query: 1   MELSVLLFLALLTGL--LLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRF 58
           M L +LLFL LL GL  LL    + P+   R PPGPRPLPL+GNL  +      +S +  
Sbjct: 1   MALLLLLFLGLL-GLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMEL 59

Query: 59  REKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANG 118
            E+YG VFTVHLG +  V+L G EA++EAL    +  + R  IA+     RG G+ F++G
Sbjct: 60  SERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSG 119

Query: 119 NRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANI 178
            RW+  R+F+V  +   G+G+  V ++I +E +CL  +L   +G    P  L     +NI
Sbjct: 120 ARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNI 178

Query: 179 ICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL 238
             +++FG+RF Y+D  F+ +L L  +   L+ S   QLF ++  +L      HR V + +
Sbjct: 179 TFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYP-WLGALLQLHRPVLRKI 237

Query: 239 QEINAYIGHSVEKHRETLDPSAPKDLIDTYL--LHMEKEKSNAHSEFSHQNLNLNTLSLF 296
           +E+ A +   +E  R  + P  P   + +Y+  L  + +  +    F+  N    TL + 
Sbjct: 238 EEVRAILRTLLEARRPHVCPGDP---VCSYVDALIQQGQGDDPEGLFAEANAVACTLDMV 294

Query: 297 FAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEI 356
            AGTETTS TL++  LLM ++P V  RV  E+++V+GP R P L D+  +PYT AV++E+
Sbjct: 295 MAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEV 354

Query: 357 QRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDA 416
           QRF  LLP  VP      T   G+++PK T V  +L++ L D   ++ P  FNP HFLDA
Sbjct: 355 QRFITLLPH-VPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDA 413

Query: 417 NGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP--VAPEDIDLTP 472
           NG   K EAF+PFS G+R+C+GE +AR ELFL F  +LQ + +  P  V+P  +D TP
Sbjct: 414 NGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTP 471


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  306 bits (785), Expect = 2e-83
 Identities = 176/463 (38%), Positives = 270/463 (58%), Gaps = 35/463 (7%)

Query: 30  LPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE---------------------------KY 62
           +PPGP P PL+GN   +    LL  FLR R                             Y
Sbjct: 59  IPPGPTPWPLVGNFGHV----LLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVY 114

Query: 63  GDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFAN-GNRW 121
           G +F+  +G   VV+L    ++REALV +AE FS R ++ ++    +  GV+FA+ G  W
Sbjct: 115 GSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYGPVW 174

Query: 122 KVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICS 181
           +  R+FS +T+R FG+GK S+E +I EE + +  E++K       P  +  +  +NIICS
Sbjct: 175 RQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICS 234

Query: 182 IVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFP-GAHRQVYKNLQE 240
           + FG+RF Y + EF KML    +   +  +    L  +   +L Y P G  +++ +  ++
Sbjct: 235 LCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICP-WLYYLPFGPFKELRQIEKD 293

Query: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKE-KSNAHSEFSHQNLNLNTLSLFFAG 299
           I +++   ++ H+E+LD   P+D ID YLLHME+E K+N++S F  + L      LF AG
Sbjct: 294 ITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAG 353

Query: 300 TETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRF 359
           T+TT+ +L +  L M   P V E+V+ EIE+VIG +R P L D+A+MPYTEA I E+QR 
Sbjct: 354 TDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRL 413

Query: 360 SDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGA 419
           + ++P+ +PH+ +++T  +GY IPK T +   L +   DP  +EKP+ F P+ FLD  G 
Sbjct: 414 TVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQ 473

Query: 420 LKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP 462
           L K E FIPF +GKR+C+GE +A+ ELFL F +++Q+F+ A P
Sbjct: 474 LIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALP 516


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  293 bits (751), Expect = 2e-79
 Identities = 166/462 (35%), Positives = 258/462 (55%), Gaps = 11/462 (2%)

Query: 7   LFLALLT-GLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREK--YG 63
           LFL L   G+  LL QR P      PPGP  LP +GN+  +     L      ++   YG
Sbjct: 18  LFLLLFALGVRQLLKQRRPMG---FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYG 74

Query: 64  DVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFAN-GNRWK 122
           ++F++ LG    V+L G + ++E LV ++E F+ R  + +     +  G++ +  G  W 
Sbjct: 75  EIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWV 134

Query: 123 VLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSI 182
             RR +V + R FG G++S E +I EE +   + +   KG   D   L  +  +NI   I
Sbjct: 135 DHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLI 194

Query: 183 VFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFS--GFLKYFPGAHRQVYKNLQE 240
           +FG+RF Y+D +F  M+ LF +   L +S    L+  F   G L +  G H+Q+++N   
Sbjct: 195 IFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF--GKHQQLFRNAAV 252

Query: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300
           +  ++   +EK      P  P+  +D YL  M++ K++  S FS +NL  +   L  AGT
Sbjct: 253 VYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGT 312

Query: 301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360
           ETT+  LR+  L M  YP++  +V +EI+ ++GP+  P   D+ KMPYTEAV++E+ RF 
Sbjct: 313 ETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFC 372

Query: 361 DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420
           +++P+G+ H  ++    RGY IPK T V   L +   D  Y+  P+ F+P+ FLD++G  
Sbjct: 373 NIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYF 432

Query: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP 462
            K EA +PFSLG+R CLGE +AR E+FLFFT +LQ F +  P
Sbjct: 433 AKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFP 474


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  290 bits (743), Expect = 2e-78
 Identities = 183/498 (36%), Positives = 259/498 (52%), Gaps = 59/498 (11%)

Query: 1   MELSVLLFLALLTGLLLLLVQ---RHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLR 57
           M L  L+ LA++  + LLLV    R      R PPGP PLP LGNLL +D +     F +
Sbjct: 1   MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60

Query: 58  FREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFAN 117
            R ++GDVF++ L   PVV+L G+ A+REALV   E  + R  +                
Sbjct: 61  LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVP--------------- 105

Query: 118 GNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITAN 177
                      +T +  FG                      +S+G    P  L     +N
Sbjct: 106 -----------ITQILGFGP---------------------RSQGRPFRPNGLLDKAVSN 133

Query: 178 IICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKN 237
           +I S+  G+RF Y D  FL++L+L  +     S    ++       L + P    +V + 
Sbjct: 134 VIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL-HIPALAGKVLRF 192

Query: 238 LQEINAYIGHSVEKHRETLDPSAP-KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLF 296
            +     +   + +HR T DP+ P +DL + +L  MEK K N  S F+ +NL +    LF
Sbjct: 193 QKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLF 252

Query: 297 FAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEI 356
            AG  TTSTTL +G LLM+ +P V  RV +EI+ VIG  R PE+ D+A MPYT AVI+E+
Sbjct: 253 SAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEV 312

Query: 357 QRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDA 416
           QRF D++P+GV H+ ++    +G+ IPK T +   LS+ L D   +EKP  F+P+HFLDA
Sbjct: 313 QRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDA 372

Query: 417 NGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECG 476
            G   K EAF+PFS G+R CLGE +AR ELFLFFT++LQ+FS + P         P   G
Sbjct: 373 QGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQP----RPSHHG 428

Query: 477 VGKI---PPTYQIRFLPR 491
           V      P  Y++  +PR
Sbjct: 429 VFAFLVTPSPYELCAVPR 446


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  241 bits (615), Expect = 1e-63
 Identities = 162/492 (32%), Positives = 265/492 (53%), Gaps = 27/492 (5%)

Query: 2   ELSVLLFLALLTGLLL---LLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRF 58
           + ++LL L++L  + +   LL QR        PPGP   PL+GN   + +   L SF R 
Sbjct: 20  QTTLLLLLSVLATVHVGQRLLRQRRRQLRSA-PPGPFAWPLIGNAAAVGQAAHL-SFARL 77

Query: 59  REKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFAN- 117
             +YGDVF + LG  P+V+L G  AI +ALV +  AF+ R   A       G  + F + 
Sbjct: 78  ARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHY 137

Query: 118 GNRWKVLRRFSVTTMRDF----GMGKRSVEERIQEEAQCLIEELRKSK--GALMDPTFLF 171
              WKV RR + + MR+F       ++ +E  +  EA+ L+  L +    GA +DP  L 
Sbjct: 138 SEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLT 197

Query: 172 QSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAH 231
               AN++ ++ FG R+ + D EF ++L+   +    + +  G L ++   +L+YFP   
Sbjct: 198 VVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGA--GSLVDVMP-WLQYFPNPV 254

Query: 232 RQVYKNLQEINA----YIGHSVEKHRETLDP-SAPKDLIDTYLLHMEKEKS-NAH---SE 282
           R V++  +++N     +I     +H E+L P +AP+D++D ++L  EK+ + ++H   + 
Sbjct: 255 RTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGAR 314

Query: 283 FSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHD 342
              +N+      +F A  +T ST L++  LL  +YP V  RV  E++QV+G  R P + D
Sbjct: 315 LDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGD 374

Query: 343 RAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYF 402
           +  +PY  A +YE  RFS  +P+ +PH  T +TS  GY IPKDT VF+   +  HDP  +
Sbjct: 375 QPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKW 434

Query: 403 EKPDAFNPDHFLDANGALKK--TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSM- 459
             P+ F+P  FLD +G + K  T   + FS+GKR C+GE +++ +LFLF + +       
Sbjct: 435 PNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFR 494

Query: 460 ASPVAPEDIDLT 471
           A+P  P  ++ +
Sbjct: 495 ANPNEPAKMNFS 506


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  233 bits (594), Expect = 3e-61
 Identities = 146/459 (31%), Positives = 243/459 (52%), Gaps = 23/459 (5%)

Query: 31  PPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVD 90
           PPGP   PL+G++L + +   L +  R  ++YGDV  + +G  PVV+L G++ IR+ALV 
Sbjct: 40  PPGPWGWPLIGHMLTLGKNPHL-ALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVR 98

Query: 91  KAEAFSGRGKIAMVDPFFRGYGVIFA--NGNRWKVLRRFSVTTMRDFGMGKRS------- 141
           + + F GR  +        G  + F+  +G  W   RR +   ++ F +           
Sbjct: 99  QGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCY 158

Query: 142 VEERIQEEAQCLI---EELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKM 198
           +EE + +EA+ LI   +EL    G      ++  S+T N+IC+I FG+R+ +  QE L +
Sbjct: 159 LEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVT-NVICAICFGRRYDHNHQELLSL 217

Query: 199 LNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE-INAYIGHSVEKHRETLD 257
           +NL      ++ S  G   + F   L+Y P      +K+L E   +++   V++H +T +
Sbjct: 218 VNLNNNFGEVVGS--GNPAD-FIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFE 274

Query: 258 PSAPKDLIDTYLLHMEKEK--SNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML 315
               +D+ D+ + H ++++   NA+ + S + +    L LF AG +T +T + +  + ++
Sbjct: 275 KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 334

Query: 316 KYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHT 375
             P V  ++  E++ VIG  R P L DR+ +PY EA I E  R S  +P  +PH  T+ T
Sbjct: 335 MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDT 394

Query: 376 SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK--TEAFIPFSLGK 433
           S +G+ IPK   VF+      HD   +  P  F P+ FL  +GA+ K  +E  I F +GK
Sbjct: 395 SLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGK 454

Query: 434 RICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTP 472
           R C+GE IAR E+FLF   +LQ    + P+  + +D+TP
Sbjct: 455 RKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTP 492


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  204 bits (519), Expect = 1e-52
 Identities = 134/457 (29%), Positives = 225/457 (49%), Gaps = 20/457 (4%)

Query: 31  PPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVD 90
           PP P   PLLG++L + +   L +  R  ++YGDV  + +G  PV++L  ++ IR+ALV 
Sbjct: 42  PPEPWGWPLLGHVLTLGKNPHL-ALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVR 100

Query: 91  KAEAFSGRGKIAMVDPFFRGYGVIFA--NGNRWKVLRRFSVTTMRDFGMGKRS------- 141
           + + F GR  +        G  + F+  +G  W   RR +   +  F +           
Sbjct: 101 QGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCY 160

Query: 142 VEERIQEEAQCLIEELRKSKGAL--MDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 199
           +EE + +EA+ LI  L++        DP        AN+I ++ FG+ F     E L ++
Sbjct: 161 LEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLV 220

Query: 200 NLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL-QEINAYIGHSVEKHRETLDP 258
              ++     SS  G   + F   L+Y P    Q +K   Q    ++  +V++H +  D 
Sbjct: 221 KNTHEFVETASS--GNPLDFFP-ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDK 277

Query: 259 SAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYP 318
           ++ +D+      H +K    + +    + +      +F AG +T +T + +  + ++  P
Sbjct: 278 NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKP 337

Query: 319 HVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR 378
            +  ++ +E++ VIG  R P L DR ++PY EA I E  R S  LP  +PH  T+ T+  
Sbjct: 338 EIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLN 397

Query: 379 GYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANG-ALKK--TEAFIPFSLGKRI 435
           G+ IPK   VF+      HDP  +E P  F P+ FL A+G A+ K  +E  + F +GKR 
Sbjct: 398 GFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRR 457

Query: 436 CLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTP 472
           C+GE +A+ E+FLF   +LQ    + P   + +DLTP
Sbjct: 458 CIGEVLAKWEIFLFLAILLQQLEFSVPPGVK-VDLTP 493


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  182 bits (463), Expect = 5e-46
 Identities = 138/473 (29%), Positives = 231/473 (48%), Gaps = 19/473 (4%)

Query: 2   ELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLL-KSFLRFRE 60
           EL  LL L L    L    +R P    + P     LPL+G+L  + R G +  +F + ++
Sbjct: 3   ELVALLLLTL--AYLFWPKRRCPGA--KYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQK 58

Query: 61  KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGY-GVIFAN-G 118
           KYG +++V +G +  V++   +  +E L+ K + FSGR ++A +D       G+ FA+ G
Sbjct: 59  KYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSG 118

Query: 119 NRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANI 178
             W++ RR ++ T   F  G + +E+ I +E   L + L    G  +D +F       N+
Sbjct: 119 AHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNV 178

Query: 179 ICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL 238
           I  I F   +   D E   + N        +S     L +L   +LK FP    +  K+ 
Sbjct: 179 ISLICFNTSYKNGDPELNVIQNYNEGIIDNLSK--DSLVDLVP-WLKIFPNKTLEKLKSH 235

Query: 239 QEI-NAYIGHSVEKHRETLDPSAPKDLIDTYL-LHMEKEKSNA----HSEFSHQNLNLNT 292
            +I N  +   +E ++E     +  +++DT +   M  +  NA     SE    N  L T
Sbjct: 236 VKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTT 295

Query: 293 LS-LFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEA 351
           +  +F AG ETT++ +++    +L  P V +++Y EI+Q +G  R P + DR ++   EA
Sbjct: 296 IGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEA 355

Query: 352 VIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPD 411
            I E+ R   + PM +PH     +S   + + K TEV + L    H+   + +PD F P+
Sbjct: 356 TIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPE 415

Query: 412 HFLDANGA--LKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP 462
            FL+  G   +  + +++PF  G R C+GE +AR ELFL    +LQ F +  P
Sbjct: 416 RFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  161 bits (407), Expect = 1e-39
 Identities = 144/507 (28%), Positives = 243/507 (47%), Gaps = 44/507 (8%)

Query: 3   LSVLLFLALLTGLLLL-----LVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLR 57
           L +LL L LL G  LL     L   H      LPP     P   +LLQ D   L    L 
Sbjct: 4   LGLLLLLPLLAGARLLWNWWKLRSLH------LPP---LAPGFLHLLQPD---LPIYLLG 51

Query: 58  FREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFAN 117
             +K+G ++ +HLG + VV+L     I EA+V K   F+GR +        R Y  +   
Sbjct: 52  LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLG 111

Query: 118 GNR--WKVLRRFSVTTMRDFGMGKR-SVEERIQEEAQCLIEELRKSKGALMDPTFLFQSI 174
                WK  ++ + + +    +G R S+E  +++  Q   E +R   G  +     F  +
Sbjct: 112 DYSLLWKAHKKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLL 168

Query: 175 TANIICSIVFGKRFHYQD--QEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAH- 231
           T +IIC + FG +    +    + K +    +T+S  S    Q+ ++   FL++FP    
Sbjct: 169 TCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSI---QIVDVIP-FLRFFPNPGL 224

Query: 232 RQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKS--NAHSEFSHQNLN 289
           R++ + +++ +  +   + +H+E+L     +D++D Y+L    + S      +    +++
Sbjct: 225 RRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMD-YMLQGVAQPSMEEGSGQLLEGHVH 283

Query: 290 LNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP----HRPPELHDRAK 345
           +  + L   GTETT+ TL +  + +L +P + +R+  E++  +GP     R P   DRA+
Sbjct: 284 MAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRAR 342

Query: 346 MPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKP 405
           +P   A I E+ R   ++P+ +PH  T+ +S  GY IP+ T +   L  A  D   +E+P
Sbjct: 343 LPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERP 402

Query: 406 DAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS-MASPVA 464
             F PD FL+      K    + F  G R+CLGE +AR ELF+  T +LQ F+ + S  A
Sbjct: 403 HEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDA 458

Query: 465 PEDIDLTPQECGVGKIPPTYQIRFLPR 491
              +   P    + K+ P +Q+R  PR
Sbjct: 459 LPSLQPLPHCSVILKMQP-FQVRLQPR 484


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  140 bits (352), Expect = 3e-33
 Identities = 134/505 (26%), Positives = 234/505 (46%), Gaps = 70/505 (13%)

Query: 3   LSVLLFLALLTGLLLL-----LVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLR 57
           L +LL L LL G  LL     L   H      LPP     P   +LLQ D   L    L 
Sbjct: 4   LGLLLLLPLLAGARLLWNWWKLRSLH------LPP---LAPGFLHLLQPD---LPIYLLG 51

Query: 58  FREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFAN 117
             +K+G ++ +HLG            +++ LV +       G  +++             
Sbjct: 52  LTQKFGPIYRLHLG------------LQDKLVSRNYPDLSLGDYSLL------------- 86

Query: 118 GNRWKVLRRFSVTTMRDFGMGKR-SVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITA 176
              WK  ++ + + +    +G R S+E  +++  Q   E +R   G  +     F  +T 
Sbjct: 87  ---WKAHKKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 140

Query: 177 NIICSIVFGKRFHYQD--QEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAH-RQ 233
           +IIC + FG +    +    + K +    +T+S  S    Q+ ++   FL++FP    R+
Sbjct: 141 SIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSI---QIVDVIP-FLRFFPNPGLRR 196

Query: 234 VYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKS--NAHSEFSHQNLNLN 291
           + + +++ +  +   + +H+E+L     +D++D Y+L    + S      +    ++++ 
Sbjct: 197 LKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMD-YMLQGVAQPSMEEGSGQLLEGHVHMA 255

Query: 292 TLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP----HRPPELHDRAKMP 347
            + L   GTETT+ TL +  + +L +P + +R+  E++  +GP     R P   DRA++P
Sbjct: 256 AVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLP 314

Query: 348 YTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDA 407
              A I E+ R   ++P+ +PH  T+ +S  GY IP+ T +   L  A  D   +E+P  
Sbjct: 315 LLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHE 374

Query: 408 FNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS-MASPVAPE 466
           F PD FL+      K    + F  G R+CLGE +AR ELF+  T +LQ F+ + S  A  
Sbjct: 375 FWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALP 430

Query: 467 DIDLTPQECGVGKIPPTYQIRFLPR 491
            +   P    + K+ P +Q+R  PR
Sbjct: 431 SLQPLPHCSVILKMQP-FQVRLQPR 454


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  127 bits (319), Expect = 2e-29
 Identities = 113/467 (24%), Positives = 204/467 (43%), Gaps = 35/467 (7%)

Query: 30  LPPGPRPLPLLGNLLQM--DRRGLLKSFLRFREKYGDVFTVHL--GPRPVVMLCGVEAIR 85
           +P   R  PL+G+ L M  D R   +  + + E+Y  +  + L  GP P+V L   E + 
Sbjct: 50  IPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENV- 108

Query: 86  EALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRR-----FSVTTMRDFGMGKR 140
           E ++  ++          ++P+  G G++ + GN+W+  R+     F  T + DF     
Sbjct: 109 EVILTSSKQIDKSSMYKFLEPWL-GLGLLTSTGNKWRSRRKMLTPTFHFTILEDF----- 162

Query: 141 SVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITA-NIICSIVFGKRFHYQDQEFLKML 199
              + + E+A  L+++L K         F + ++ A +IIC    GK    Q  +  + +
Sbjct: 163 --LDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYV 220

Query: 200 NLFYQTFSLI-SSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDP 258
              Y+   +I   +      L   +L +  G   +  K+LQ ++ +    + +    ++ 
Sbjct: 221 RAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHK--KSLQILHTFTNSVIAERANEMNA 278

Query: 259 ----------SAP-KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTL 307
                     SAP K+    +L  +     +  +  SH+++     +  F G +TT+  +
Sbjct: 279 NEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAI 338

Query: 308 RYGFLLMLKYPHVAERVYREIEQVIGPH-RPPELHDRAKMPYTEAVIYEIQRFSDLLPMG 366
            +   L+   P V ++V  E++ V G   RP  + D  K+ Y E VI E  R    +P+ 
Sbjct: 339 NWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPL- 397

Query: 367 VPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAF 426
               V++     GY + K TE  +I      DP YF  P+ F P+ F   N   +   A+
Sbjct: 398 FARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAY 457

Query: 427 IPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQ 473
           +PFS G R C+G+  A  E     + IL++F + S    E++ L  Q
Sbjct: 458 VPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQ 504


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  126 bits (316), Expect = 5e-29
 Identities = 122/465 (26%), Positives = 199/465 (42%), Gaps = 27/465 (5%)

Query: 7   LFLALLTGLLLLLVQRHPNTHDRLP-PGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDV 65
           L LA+   LL L   R      RL  PGP PLPLLGN+L   R+GL K      +KYG +
Sbjct: 13  LLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSY-RQGLWKFDTECYKKYGKM 71

Query: 66  FTVHLGPRPVVMLCGVEAIREALVDKA-EAFSGRGKIAMVDPFFRGYGVIFANGNRWKVL 124
           +  + G  PV+ +   + IR  LV +    F+ R  +  V   F    +  A    WK +
Sbjct: 72  WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVG--FMKSAISLAEDEEWKRI 129

Query: 125 RRFSVTTMRDFGMGK-RSVEERIQEEAQCLIEELRKS--KGALMDPTFLFQSITANIICS 181
           R     T   F  GK + +   I +    L+  LR+   KG  +    +F + + ++I  
Sbjct: 130 RSLLSPT---FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITG 186

Query: 182 IVFGKRF---HYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL 238
             FG      +     F++    F + F  +  +F  +  LF      F   +  ++   
Sbjct: 187 TSFGVNIDSLNNPQDPFVESTKKFLK-FGFLDPLFLSII-LFPFLTPVFEALNVSLFPK- 243

Query: 239 QEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSN---AHSEFSHQNLNLNTLSL 295
             IN ++  SV + +++      K  +D   L ++ + S    +H   S   L   ++  
Sbjct: 244 DTIN-FLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIF 302

Query: 296 FFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYE 355
            FAG ETTS+ L +    +  +P V +++ +EI+ V+    PP      +M Y + V+ E
Sbjct: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362

Query: 356 IQRFSDLLPMGV--PHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHF 413
             R   L P+ +       +     G  IPK + V +      HDP Y+ +P+ F P+ F
Sbjct: 363 TLR---LFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF 419

Query: 414 LDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS 458
                ++     + PF  G R C+G   A   + L    +LQNFS
Sbjct: 420 SKKKDSI-DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  124 bits (312), Expect = 1e-28
 Identities = 113/446 (25%), Positives = 199/446 (44%), Gaps = 39/446 (8%)

Query: 32  PGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDK 91
           PGP PLP LG +L    RGL        EKYG+++ ++ G +P++++   + I+  LV +
Sbjct: 39  PGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKE 97

Query: 92  A-EAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEA 150
               F+ +  +  +   F    + FA    WK +R     T+          +E +   +
Sbjct: 98  CYSVFTNQMPLGPMG--FLKSALSFAEDEEWKRIR-----TLLSPAFTSVKFKEMVPIIS 150

Query: 151 QC---LIEELRKS--KGALMDPTFLFQSITANIICSIVFGKRF----HYQD---QEFLKM 198
           QC   L+  LR+       ++    F + T ++I   +FG       + QD   +   K+
Sbjct: 151 QCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKL 210

Query: 199 LNL-FYQTFSLISSVFGQLFELFSGF-LKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL 256
           L L F   F L+ S+F  L  +F    +  FP          +++  ++ +S+E+ +E+ 
Sbjct: 211 LKLDFLDPFLLLISLFPFLTPVFEALNIGLFP----------KDVTHFLKNSIERMKESR 260

Query: 257 DPSAPKDLIDTYLLHMEKEKSN---AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLL 313
                K  +D +   ++ + S    +H   S   L   ++ + FA  +TTSTTL +    
Sbjct: 261 LKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYE 320

Query: 314 MLKYPHVAERVYREIEQVIGPHRPPELHDR-AKMPYTEAVIYEIQRFSDLLPMGVPHIVT 372
           +  +P V +++  EI+ V+ P++ P  +D   +M Y + V+ E  R   ++   V  +  
Sbjct: 321 LATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSR-VTRVCK 378

Query: 373 QHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLG 432
           +     G  IPK   V + +    HDP Y+ +P+ F P+ F   N        +IPF  G
Sbjct: 379 KDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAG 438

Query: 433 KRICLGEGIARAELFLFFTTILQNFS 458
            R C+G   A   + L     LQNFS
Sbjct: 439 PRNCIGMRFALTNIKLAVIRALQNFS 464


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  122 bits (307), Expect = 6e-28
 Identities = 119/444 (26%), Positives = 189/444 (42%), Gaps = 35/444 (7%)

Query: 32  PGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDK 91
           PGP PLP LGN+L    +G     +   +KYG V+  + G +PV+ +   + I+  LV +
Sbjct: 39  PGPTPLPFLGNILSY-HKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 97

Query: 92  A-EAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK-RSVEERIQEE 149
               F+ R     V   F    +  A    WK LR     T   F  GK + +   I + 
Sbjct: 98  CYSVFTNRRPFGPVG--FMKSAISIAEDEEWKRLRSLLSPT---FTSGKLKEMVPIIAQY 152

Query: 150 AQCLIEELRKSKGALMDPTF--LFQSITANIICSIVFGKRF----HYQD---QEFLKMLN 200
              L+  LR+        T   +F + + ++I S  FG       + QD   +   K+L 
Sbjct: 153 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 212

Query: 201 L-FYQTFSLISSVFGQLFELFSGF-LKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDP 258
             F   F L  +VF  L  +     +  FP          +E+  ++  SV++ +E+   
Sbjct: 213 FDFLDPFFLSITVFPFLIPILEVLNICVFP----------REVTNFLRKSVKRMKESRLE 262

Query: 259 SAPKDLIDTYLLHMEKEKSN---AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML 315
              K  +D   L ++ + S    +H   S   L   ++   FAG ETTS+ L +    + 
Sbjct: 263 DTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELA 322

Query: 316 KYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHT 375
            +P V +++  EI+ V+    PP      +M Y + V+ E  R    + M +  +  +  
Sbjct: 323 THPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDV 381

Query: 376 SFRGYIIPKDTEVFLILSTALH-DPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR 434
              G  IPK   V +I S ALH DP Y+ +P+ F P+ F   N        + PF  G R
Sbjct: 382 EINGMFIPKGV-VVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR 440

Query: 435 ICLGEGIARAELFLFFTTILQNFS 458
            C+G   A   + L    +LQNFS
Sbjct: 441 NCIGMRFALMNMKLALIRVLQNFS 464


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  120 bits (300), Expect = 4e-27
 Identities = 113/447 (25%), Positives = 199/447 (44%), Gaps = 40/447 (8%)

Query: 32  PGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDK 91
           PGP PLP LG +L    RGL        EKYG+++ ++ G +P++++   + I+  LV +
Sbjct: 39  PGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKE 97

Query: 92  A-EAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEA 150
               F+ +  +  +   F    + FA    WK +R     T+          +E +   +
Sbjct: 98  CYSVFTNQMPLGPMG--FLKSALSFAEDEEWKRIR-----TLLSPAFTSVKFKEMVPIIS 150

Query: 151 QC---LIEELRKS--KGALMDPTFLFQSITANIICSIVFGKRF----HYQD---QEFLKM 198
           QC   L+  LR+       ++    F + T ++I   +FG       + QD   +   K+
Sbjct: 151 QCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKL 210

Query: 199 LNL-FYQTFSLISSVFGQLFELFSGF-LKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL 256
           L L F   F L+ S+F  L  +F    +  FP          +++  ++ +S+E+ +E+ 
Sbjct: 211 LKLDFLDPFLLLISLFPFLTPVFEALNIGLFP----------KDVTHFLKNSIERMKESR 260

Query: 257 DPSAPKDLIDTYLLHMEKEKSN---AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLL 313
                K  +D +   ++ + S    +H   S   L   ++ + FA  +TTSTTL +    
Sbjct: 261 LKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYE 320

Query: 314 MLKYPHVAERVYREIEQVIGPHRPPELHDR-AKMPYTEAVIYEIQRFSDLLPMGVPHIVT 372
           +  +P V +++  EI+ V+ P++ P  +D   +M Y + V+ E  R   ++   V  +  
Sbjct: 321 LATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSR-VTRVCK 378

Query: 373 QHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPD-HFLDANGALKKTEAFIPFSL 431
           +     G  IPK   V + +    HDP Y+ +P+ F P+  F   N        +IPF  
Sbjct: 379 KDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGA 438

Query: 432 GKRICLGEGIARAELFLFFTTILQNFS 458
           G R C+G   A   + L     LQNFS
Sbjct: 439 GPRNCIGMRFALTNIKLAVIRALQNFS 465


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.142    0.427 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,149,125
Number of Sequences: 37866
Number of extensions: 868714
Number of successful extensions: 2949
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2736
Number of HSP's gapped (non-prelim): 102
length of query: 491
length of database: 18,247,518
effective HSP length: 106
effective length of query: 385
effective length of database: 14,233,722
effective search space: 5479982970
effective search space used: 5479982970
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.