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Search of human proteins with 7706379
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7706379 ankyrin repeat and SOCS box-containing protein 4
isoform a [Homo sapiens]
(426 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isof... 887 0.0
gi|22208964 ankyrin repeat and SOCS box-containing protein 4 iso... 675 0.0
gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo sap... 243 2e-64
gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3... 213 3e-55
gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1... 210 2e-54
gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [H... 196 3e-50
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 174 2e-43
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 99 1e-20
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 96 5e-20
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 96 5e-20
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 96 5e-20
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 96 5e-20
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 96 5e-20
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 94 2e-19
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 92 7e-19
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 92 7e-19
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 92 7e-19
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 92 1e-18
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 91 2e-18
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 91 2e-18
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 89 1e-17
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 87 2e-17
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 86 5e-17
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 85 1e-16
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 85 1e-16
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 85 1e-16
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 85 1e-16
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 84 3e-16
gi|13129098 ankyrin repeat and SOCS box-containing 8 [Homo sapiens] 80 4e-15
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 79 8e-15
>gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isoform
a [Homo sapiens]
Length = 426
Score = 887 bits (2293), Expect = 0.0
Identities = 426/426 (100%), Positives = 426/426 (100%)
Query: 1 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASY 60
MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASY
Sbjct: 1 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASY 60
Query: 61 KQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANV 120
KQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANV
Sbjct: 61 KQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANV 120
Query: 121 DCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLH 180
DCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLH
Sbjct: 121 DCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLH 180
Query: 181 TAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLD 240
TAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLD
Sbjct: 181 TAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLD 240
Query: 241 YKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRP 300
YKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRP
Sbjct: 241 YKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRP 300
Query: 301 AAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPD 360
AAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPD
Sbjct: 301 AAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPD 360
Query: 361 DDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLE 420
DDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLE
Sbjct: 361 DDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLE 420
Query: 421 PEGIIY 426
PEGIIY
Sbjct: 421 PEGIIY 426
>gi|22208964 ankyrin repeat and SOCS box-containing protein 4
isoform b [Homo sapiens]
Length = 349
Score = 675 bits (1742), Expect = 0.0
Identities = 327/327 (100%), Positives = 327/327 (100%)
Query: 1 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASY 60
MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASY
Sbjct: 1 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASY 60
Query: 61 KQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANV 120
KQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANV
Sbjct: 61 KQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANV 120
Query: 121 DCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLH 180
DCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLH
Sbjct: 121 DCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLH 180
Query: 181 TAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLD 240
TAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLD
Sbjct: 181 TAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLD 240
Query: 241 YKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRP 300
YKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRP
Sbjct: 241 YKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRP 300
Query: 301 AAQPEICYQLLLNHGAARIYPPQFHKV 327
AAQPEICYQLLLNHGAARIYPPQFHKV
Sbjct: 301 AAQPEICYQLLLNHGAARIYPPQFHKV 327
>gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo
sapiens]
Length = 466
Score = 243 bits (620), Expect = 2e-64
Identities = 146/404 (36%), Positives = 208/404 (51%), Gaps = 13/404 (3%)
Query: 29 DFGKLKAILIQRQIDVDTVFEVEDENMVLASYK------QGYWLPSYKLKSSWATGLHLS 82
D LK ++ Q D + VFE+ + M G W YK + + T L ++
Sbjct: 70 DLDHLKPLMDQFFQDANVVFEINKDEMEWQVKSPATFGLSGLWTLEYKRELT--TPLCIA 127
Query: 83 VLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHT 142
GH C+ LL A + P G+ LH AC + CV++L A + S G
Sbjct: 128 AAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLLQHRADPDLLSAEGLA 187
Query: 143 ALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVD 202
LH C T +S+ CA+ L+ GA+V + +TPLH AA GL E Y+ GA VD
Sbjct: 188 PLHLCRTAASLGCAQALLEHGASVQ-RVGGTGRDTPLHVAAQRGLDEHARLYLGRGAHVD 246
Query: 203 SVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWN 262
+ N ET L+ A A R E +C +LL AE +ARD+D +SPLHKA +
Sbjct: 247 ARNGRGETALSAACGAARRPDEHGRCLR---LCALLLRRGAEADARDEDERSPLHKACGH 303
Query: 263 CDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPP 322
H L ++L GA+A +D G + + VL+ S A P+ Q LLNHG+ ++P
Sbjct: 304 ASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQALLNHGSPTVWPD 363
Query: 323 QFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSPR 382
F KV++ C S P IEV+ N+Y + + W+ IP++ + + FY SLF + +PR
Sbjct: 364 AFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEVFQMHKPFYQSLFALAL-TPR 422
Query: 383 TLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGIIY 426
L HL RCA+RR RC IPLL LP L+ YLLLEP+G+++
Sbjct: 423 CLQHLCRCALRRLFGKRCFDLIPLLPLPKPLQNYLLLEPQGVLH 466
>gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3
[Homo sapiens]
Length = 452
Score = 213 bits (542), Expect = 3e-55
Identities = 137/405 (33%), Positives = 205/405 (50%), Gaps = 7/405 (1%)
Query: 24 ALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASYKQGYWLPSYKLKSSWATGLHLSV 83
AL + D +L+ L D + E +S+++G W +Y+ T LH++
Sbjct: 53 ALYTGDLARLQE-LFPPHSTADLLLESRAAEPRWSSHQRGLWSLTYE--EELTTPLHVAA 109
Query: 84 LFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTA 143
GH E L +LL A + P G+T LH AC + CV +L GA N G
Sbjct: 110 SRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRP 169
Query: 144 LHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDS 203
LH C P ++ CA+ L+ GA V+ ++ ++EETPLH AA G EL + GA D+
Sbjct: 170 LHLCRGPGTLECAELLLRFGARVDGRSE-EEEETPLHVAARLGHVELADLLLRRGACPDA 228
Query: 204 VNAHMETPLAIAAYWALR-FKEQEYSTEHHL-VCRMLLDYKAEVNARDDDFKSPLHKAAW 261
NA TPL A + + E +T L +C +LL A+ +A D D + PLH A
Sbjct: 229 RNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACR 288
Query: 262 NCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYP 321
++ ++L G AN MD G + L+ + A PE + LLNHGA R++P
Sbjct: 289 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWP 348
Query: 322 PQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSP 381
KV++ +CP+ IEV++N Y ++ + + + L+K+ FY SLF + P
Sbjct: 349 GALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFAL-VRQP 407
Query: 382 RTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGIIY 426
R+L HLSRCA+R L +A+P L LP L +YL L+ EG++Y
Sbjct: 408 RSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 452
>gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1
[Homo sapiens]
Length = 512
Score = 210 bits (535), Expect = 2e-54
Identities = 143/430 (33%), Positives = 211/430 (49%), Gaps = 15/430 (3%)
Query: 10 KSGAAKLVKRN-------FLEALKSNDFGKLKAILIQRQIDV--DTVFEVEDENMV--LA 58
KSG +V R F +A+ + D G + IL + D+VF+ D
Sbjct: 85 KSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFR 144
Query: 59 SYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMA 118
+ L S + T LH++ GH E L +LL A + P G+T LH AC
Sbjct: 145 FNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAG 204
Query: 119 NVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETP 178
+ CV +L GA N G LH C P ++ CA+ L+ GA V+ ++ ++EETP
Sbjct: 205 HTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSE-EEEETP 263
Query: 179 LHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALR-FKEQEYSTEHHL-VCR 236
LH AA G EL + GA D+ NA TPL A + + E +T L +C
Sbjct: 264 LHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCS 323
Query: 237 MLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVT 296
+LL A+ +A D D + PLH A ++ ++L G AN MD G + L+
Sbjct: 324 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 383
Query: 297 SVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRR 356
+ A PE + LLNHGA R++P KV++ +CP+ IEV++N Y ++ +
Sbjct: 384 AAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVG 443
Query: 357 AIPDDDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKY 416
+ + L+K+ FY SLF + PR+L HLSRCA+R L +A+P L LP L +Y
Sbjct: 444 LVTPETLQKHQRFYSSLFAL-VRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRY 502
Query: 417 LLLEPEGIIY 426
L L+ EG++Y
Sbjct: 503 LQLDFEGVLY 512
>gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [Homo
sapiens]
Length = 453
Score = 196 bits (498), Expect = 3e-50
Identities = 134/403 (33%), Positives = 204/403 (50%), Gaps = 13/403 (3%)
Query: 23 EALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASYKQGYWLPSYKLKSSWATGLHLS 82
+AL S + +++A L Q + + + E N + S +QG+W+ + K K + L ++
Sbjct: 63 QALFSGNLQQVQA-LFQDEEAANMIVETVS-NQLAWSAEQGFWVLTPKTKQT--APLAIA 118
Query: 83 VLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHT 142
G+ +C L+ A ++ R G+ LH AC A DCV++L GAK N + G T
Sbjct: 119 TARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTT 178
Query: 143 ALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVD 202
LH CT P S+ CAK L+ GA VN+ + +ETPLH AA GL + VA Y+EHGA V
Sbjct: 179 PLHLCTIPESLQCAKLLLEAGATVNLAA-GESQETPLHVAAARGLEQHVALYLEHGADVG 237
Query: 203 SVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWN 262
+ ET L A A + H R LL+ A+ A +PLH A N
Sbjct: 238 LRTSQGETALNTACAGA---EGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACAN 294
Query: 263 CDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPP 322
L ++L GA A + + G + L+ P +PE+ + LL++GA + P
Sbjct: 295 GCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRP- 353
Query: 323 QFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSPR 382
++++ C + P+A+EV++NAY + W A+ + +++ FY S + N PR
Sbjct: 354 ---EMLKHCANFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCM-VNQPR 409
Query: 383 TLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGII 425
L HL+R A+R L +RC + L LP L+ YLLL EG I
Sbjct: 410 QLQHLARLAVRARLGSRCRQGATRLPLPPLLRDYLLLRVEGCI 452
>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
[Homo sapiens]
Length = 474
Score = 174 bits (440), Expect = 2e-43
Identities = 135/430 (31%), Positives = 191/430 (44%), Gaps = 53/430 (12%)
Query: 10 KSGAAKLVKRN-------FLEALKSNDFGKLKAILIQRQIDV--DTVFEVEDENMV--LA 58
KSG +V R F +A+ + D G + IL + D+VF+ D
Sbjct: 85 KSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFR 144
Query: 59 SYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMA 118
+ L S + T LH++ GH E L +LL A + P G+T LH AC
Sbjct: 145 FNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAG 204
Query: 119 NVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETP 178
+ CV +L GA N G LH C P ++ CA+ L+ GA V+ + + ++EETP
Sbjct: 205 HTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGR-SEEEEETP 263
Query: 179 LHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAA-YWALRFKEQEYSTEHHL-VCR 236
LH AA G EL + GA D+ NA TPL A + E +T L +C
Sbjct: 264 LHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCS 323
Query: 237 MLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVT 296
+LL A+ +A D D + PLH A ++ ++L G AN MD G + L+
Sbjct: 324 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 383
Query: 297 SVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRR 356
+ A PE + LLNHGA R+ W
Sbjct: 384 AAALAQSPEHVVRALLNHGAVRV----------------------------------WPG 409
Query: 357 AIPDDDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKY 416
A+P +K+ FY SLF + PR+L HLSRCA+R L +A+P L LP L +Y
Sbjct: 410 ALP----KKHQRFYSSLFAL-VRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRY 464
Query: 417 LLLEPEGIIY 426
L L+ EG++Y
Sbjct: 465 LQLDFEGVLY 474
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 98.6 bits (244), Expect = 1e-20
Identities = 74/245 (30%), Positives = 113/245 (46%), Gaps = 20/245 (8%)
Query: 73 SSWATGLHLSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCVKILCDRGA 131
S W T LH +V E + VLL H+A +N R N +TPLH+A V C + L +
Sbjct: 72 SKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLS 131
Query: 132 KLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELV 191
+N +G TALH K L+ RGAN+N ++ + +H AA+ G E+V
Sbjct: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANIN--AFDKKDRRAIHWAAYMGHIEVV 189
Query: 192 AFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDD 251
V HGA V + TPL AA S+ V + LLD ++N +
Sbjct: 190 KLLVSHGAEVTCKDKKSYTPLHAAA-----------SSGMISVVKYLLDLGVDMNEPNAY 238
Query: 252 FKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLL 311
+PLH A +N V+++ +++ GA N + G + + T +C +LL
Sbjct: 239 GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAAST------HGALCLELL 292
Query: 312 LNHGA 316
+ +GA
Sbjct: 293 VGNGA 297
Score = 84.7 bits (208), Expect = 1e-16
Identities = 77/271 (28%), Positives = 109/271 (40%), Gaps = 57/271 (21%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPN--GKTPLHVACEMANVDCVKILCDRGAKLN 134
T LH + G + + LLD +N PN G TPLHVAC V L D GA +N
Sbjct: 208 TPLHAAASSGMISVVKYLLDLGVDMN-EPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266
Query: 135 CYSLSGHTALHFCTTPS-SILCAKQLVWRGANVNMKTNN--------------------- 172
+ G T LHF + LC + LV GA+VNMK+ +
Sbjct: 267 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII 326
Query: 173 ----------QDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWAL-- 220
++ TPLH AA +G L+ + GA H PL +AA
Sbjct: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386
Query: 221 -------------------RFKEQEYSTEHHLVC-RMLLDYKAEVNARDDDFKSPLHKAA 260
R + +L C +LL+ A+ N +D +SPLH AA
Sbjct: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
Query: 261 WNCDHVLMHMMLEAGAEANLMDINGCAAIQY 291
NC++ + ++ +GA N +D GC + Y
Sbjct: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHY 477
Score = 69.3 bits (168), Expect = 6e-12
Identities = 76/289 (26%), Positives = 130/289 (44%), Gaps = 38/289 (13%)
Query: 16 LVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDEN---MVLASYKQGYWLPSYKL- 71
++KR + A +N + +LI + V +++D N ++ S G+ Y L
Sbjct: 615 ILKRTPIHAAATNGHSECLRLLIGNAEPQNAV-DIQDGNGQTPLMLSVLNGHTDCVYSLL 673
Query: 72 --------KSSWA-TGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVD 121
K W T LH + GH EC+ LL H A R + G+TP+H++ ++
Sbjct: 674 NKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIG 733
Query: 122 CVKILCDRGAKLNCYSLS----GHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEET 177
+ L A ++ + G+TALH+ C + L+ + V KT + +
Sbjct: 734 VLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ--EVFQKTEG-NAFS 790
Query: 178 PLHTAA---HFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLV 234
PLH A + G +E++ + +IV++ ++ TPL AA+ T+H
Sbjct: 791 PLHCAVINDNEGAAEMLIDTLG-ASIVNATDSKGRTPLHAAAF-----------TDHVEC 838
Query: 235 CRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMML-EAGAEANLMD 282
++LL + A+VN+ D K+PL AA N + M++ A AE L D
Sbjct: 839 LQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQD 887
Score = 68.9 bits (167), Expect = 8e-12
Identities = 63/241 (26%), Positives = 104/241 (43%), Gaps = 35/241 (14%)
Query: 77 TGLHLSVLFGHVECLLVLLDH----NATINCRPNGKTPLHVACEMANVDCVKILCDRGAK 132
T +H + GH ECL +L+ + NA NG+TPL ++ + DCV L ++GA
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGAN 678
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
++ G TALH C L+ GA ++ + TP+H +A G ++
Sbjct: 679 VDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSR--GRTPIHLSAACGHIGVLG 736
Query: 193 FYVEHGAIVDSVNAHMETPLAIAAYWALR---------------FKEQEYSTEHHLVCRM 237
++ A +D+ A + A +WA F++ E + L C +
Sbjct: 737 ALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAV 796
Query: 238 LLDYKAE------------VNARDDDFKSPLHKAAWNCDHV-LMHMMLEAGAEANLMDIN 284
+ D + VNA D ++PLH AA+ DHV + ++L A+ N +D
Sbjct: 797 INDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFT-DHVECLQLLLSHNAQVNSVDST 855
Query: 285 G 285
G
Sbjct: 856 G 856
Score = 67.0 bits (162), Expect = 3e-11
Identities = 50/147 (34%), Positives = 72/147 (48%), Gaps = 3/147 (2%)
Query: 73 SSWATGLHLSVLFGHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKIL-CDRG 130
S T LH + HVECL +LL HNA +N GKTPL +A E + V++L
Sbjct: 821 SKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSAS 880
Query: 131 AKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNM-KTNNQDEETPLHTAAHFGLSE 189
A+L S +TALH + A ++ + + N+ N +TPLH AA GL+
Sbjct: 881 AELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTM 940
Query: 190 LVAFYVEHGAIVDSVNAHMETPLAIAA 216
+V + GA V +V+ + TP A
Sbjct: 941 VVQELLGKGASVLAVDENGYTPALACA 967
Score = 64.7 bits (156), Expect = 2e-10
Identities = 64/254 (25%), Positives = 111/254 (43%), Gaps = 37/254 (14%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH + G++ECL +LL+ A N + G++PLH A N C+ L GA +N
Sbjct: 407 TCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVND 466
Query: 136 YSLSGHTALHF-CTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFG---LSELV 191
G T LH+ T+ + C + L+ AN ++ ++ +H +A +G +L+
Sbjct: 467 LDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIR--DKQGYNAVHYSAAYGHRLCLQLI 524
Query: 192 AFYVEHGAIV---------DSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYK 242
A ++ DS N +PL +AAY HH +L+
Sbjct: 525 ASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHG-----------HHQALEVLVQSL 573
Query: 243 AEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAA 302
+++ R+ ++PL AA+ + +++ GA + D Y+LK T + AA
Sbjct: 574 LDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD--------YILKRTPIHAAA 625
Query: 303 Q--PEICYQLLLNH 314
C +LL+ +
Sbjct: 626 TNGHSECLRLLIGN 639
Score = 64.3 bits (155), Expect = 2e-10
Identities = 64/241 (26%), Positives = 108/241 (44%), Gaps = 34/241 (14%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRP-----NGKTPLHVACEMANVDCVKILCDRGA 131
T +HLS GH+ L LL A+++ P +G T LH AC + CV++L ++
Sbjct: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV 780
Query: 132 KLNCYSLSGHTALHFCTTPSSILCAKQLV-WRGANVNMKTNNQDEETPLHTAAHFGLSEL 190
+ + LH + A+ L+ GA++ T+++ TPLH AA E
Sbjct: 781 FQKTEG-NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGR-TPLHAAAFTDHVEC 838
Query: 191 VAFYVEHGAIVDSVNAHMETPLAIAAYWA---------------LRFKEQEYSTEHHLVC 235
+ + H A V+SV++ +TPL +AA L ++ +T HL C
Sbjct: 839 LQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLAC 898
Query: 236 R--------MLLDYKAE---VNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDIN 284
++L+ + +NA + ++PLH AA N +++ +L GA +D N
Sbjct: 899 SKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDEN 958
Query: 285 G 285
G
Sbjct: 959 G 959
Score = 52.0 bits (123), Expect = 1e-06
Identities = 50/192 (26%), Positives = 81/192 (42%), Gaps = 18/192 (9%)
Query: 79 LHLSVLF---GHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNC 135
LH +V+ G E L+ L + G+TPLH A +V+C+++L A++N
Sbjct: 792 LHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS 851
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTA---AHFGLSELVA 192
+G T L + LV A+ + + + T LH A H + L+
Sbjct: 852 VDSTGKTPLMMAAENGQTNTVEMLV-SSASAELTLQDNSKNTALHLACSKGHETSALLIL 910
Query: 193 FYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDF 252
+ ++++ NA ++TPL +AA L QE LL A V A D++
Sbjct: 911 EKITDRNLINATNAALQTPLHVAARNGLTMVVQE-----------LLGKGASVLAVDENG 959
Query: 253 KSPLHKAAWNCD 264
+P A N D
Sbjct: 960 YTPALACAPNKD 971
Score = 37.4 bits (85), Expect = 0.026
Identities = 23/81 (28%), Positives = 41/81 (50%), Gaps = 7/81 (8%)
Query: 236 RMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKV 295
R L+ K +VN +D++ ++PLH AA+ D ++ +++ +GA N D + +
Sbjct: 25 RALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAV-- 82
Query: 296 TSVRPAAQPEICYQLLLNHGA 316
A+ E Q+LL H A
Sbjct: 83 -----ASCSEEAVQVLLKHSA 98
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 96.3 bits (238), Expect = 5e-20
Identities = 72/241 (29%), Positives = 115/241 (47%), Gaps = 23/241 (9%)
Query: 79 LHLSVLFGHVECLLVLLDHNATINC-RPNGKTPLHVACEMANVDCVKILCDRGAKLNCYS 137
LH++ VLL ++ + G TPLH+A N++ ++L +RGA +N
Sbjct: 210 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 269
Query: 138 LSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEH 197
+G T LH + +++ + L+ RGA + KT +DE TPLH AA G + ++H
Sbjct: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKT--KDELTPLHCAARNGHVRISEILLDH 327
Query: 198 GAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVC-RMLLDYKAEVNARDDDFKSPL 256
GA + + + +P+ +AA HL C R+LL Y AE++ D +PL
Sbjct: 328 GAPIQAKTKNGLSPIHMAA------------QGDHLDCVRLLLQYDAEIDDITLDHLTPL 375
Query: 257 HKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGA 316
H AA H + ++L+ GA+ N +NG + K VR +LLL GA
Sbjct: 376 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR-------VMELLLKTGA 428
Query: 317 A 317
+
Sbjct: 429 S 429
Score = 93.2 bits (230), Expect = 4e-19
Identities = 73/243 (30%), Positives = 110/243 (45%), Gaps = 47/243 (19%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCV------------ 123
T LH + GHV +LLDH A I + NG +P+H+A + ++DCV
Sbjct: 307 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 366
Query: 124 ---------------------KILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWR 162
K+L D+GAK N +L+G T LH + + + L+
Sbjct: 367 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 426
Query: 163 GANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRF 222
GA+++ T + TPLH A+ G +V ++ GA + N +ETPL +AA
Sbjct: 427 GASIDAVT--ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA------ 478
Query: 223 KEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMD 282
H V + LL KA+VNA+ D ++PLH AA ++ ++LE A NL
Sbjct: 479 -----RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 533
Query: 283 ING 285
G
Sbjct: 534 TAG 536
Score = 89.4 bits (220), Expect = 6e-18
Identities = 71/226 (31%), Positives = 105/226 (46%), Gaps = 14/226 (6%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ GH VLLD A N R NG TPLH+AC+ +V +++L GA ++
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
+ SG T LH + + K L+ RGA+ N+ +N ETPLH AA G +E+ + +
Sbjct: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNV--SNVKVETPLHMAARAGHTEVAKYLL 490
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
++ A V++ +TPL AA H + ++LL+ A N +P
Sbjct: 491 QNKAKVNAKAKDDQTPLHCAA-----------RIGHTNMVKLLLENNANPNLATTAGHTP 539
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPA 301
LH AA + +LE A M G + K VR A
Sbjct: 540 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 585
Score = 86.3 bits (212), Expect = 5e-17
Identities = 72/274 (26%), Positives = 120/274 (43%), Gaps = 52/274 (18%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ +G V +LL+ +A N NG TPLHVA N+D VK+L RG +
Sbjct: 571 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 630
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFY- 194
+ +G+T LH + + A+ L+ G + N ++ TPLH AA G +E+VA
Sbjct: 631 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES--VQGVTPLHLAAQEGHAEMVALLL 688
Query: 195 --------------------------------VEHGAIVDSVNAHMETPLAIAAYWALRF 222
++HG +VD+ TPL +A+++
Sbjct: 689 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG--- 745
Query: 223 KEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMD 282
+ + + LL ++A+VNA+ SPLH+AA ++ ++L+ GA N +
Sbjct: 746 --------NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVS 797
Query: 283 INGCAAIQYV-----LKVTSVRPAAQPEICYQLL 311
+G + + VT V E + L+
Sbjct: 798 SDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLV 831
Score = 82.8 bits (203), Expect = 5e-16
Identities = 70/240 (29%), Positives = 102/240 (42%), Gaps = 21/240 (8%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH + GH + +LL++NA N G TPLH+A +V+ V L ++ A C
Sbjct: 505 TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 564
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
+ G T LH + A+ L+ R A+ N N TPLH A H ++V +
Sbjct: 565 MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN--GLTPLHVAVHHNNLDIVKLLL 622
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
G S + TPL IAA K+ + V R LL Y NA +P
Sbjct: 623 PRGGSPHSPAWNGYTPLHIAA------KQNQVE-----VARSLLQYGGSANAESVQGVTP 671
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHG 315
LH AA ++ ++L A NL + +G + V + V A +L+ HG
Sbjct: 672 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA-------DVLIKHG 724
Score = 67.4 bits (163), Expect = 2e-11
Identities = 71/255 (27%), Positives = 106/255 (41%), Gaps = 25/255 (9%)
Query: 70 KLKSSWATGLHLSVLFGHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCD 128
K K+ AT + G+++ L L + IN C NG LH+A + +V V L
Sbjct: 40 KKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 99
Query: 129 RGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLS 188
+ L + G+TALH ++LV GANVN +Q TPL+ AA
Sbjct: 100 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN--AQSQKGFTPLYMAAQENHL 157
Query: 189 ELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNAR 248
E+V F +E+GA + TPLA+A H V L++Y + R
Sbjct: 158 EVVKFLLENGANQNVATEDGFTPLAVA-----------LQQGHENVVAHLINYGTKGKVR 206
Query: 249 DDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICY 308
LH AA N D ++L+ +++ G + ++ A
Sbjct: 207 ----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA------- 255
Query: 309 QLLLNHGAARIYPPQ 323
QLLLN GA+ + PQ
Sbjct: 256 QLLLNRGASVNFTPQ 270
Score = 67.4 bits (163), Expect = 2e-11
Identities = 64/230 (27%), Positives = 93/230 (40%), Gaps = 16/230 (6%)
Query: 74 SWATGLHLSVLFGHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAK 132
S T LH++ GH+ + LL A+ N +TPLH+A + + K L AK
Sbjct: 436 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 495
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
+N + T LH K L+ AN N+ T TPLH AA G E V
Sbjct: 496 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT--AGHTPLHIAAREGHVETVL 553
Query: 193 FYVEHGAIVDSVNAHMETPLAIAA-YWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDD 251
+E A + TPL +AA Y +R V +LL+ A NA +
Sbjct: 554 ALLEKEASQACMTKKGFTPLHVAAKYGKVR------------VAELLLERDAHPNAAGKN 601
Query: 252 FKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPA 301
+PLH A + + ++ ++L G + NG + K V A
Sbjct: 602 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 651
Score = 51.6 bits (122), Expect = 1e-06
Identities = 41/143 (28%), Positives = 58/143 (40%), Gaps = 36/143 (25%)
Query: 74 SWATGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAK 132
S T LHL GHV VL+ H ++ G TPLHVA N+ VK L A
Sbjct: 700 SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD 759
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
+N + G+ +PLH AA G +++V
Sbjct: 760 VNAKTKLGY-----------------------------------SPLHQAAQQGHTDIVT 784
Query: 193 FYVEHGAIVDSVNAHMETPLAIA 215
+++GA + V++ TPLAIA
Sbjct: 785 LLLKNGASPNEVSSDGTTPLAIA 807
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 96.3 bits (238), Expect = 5e-20
Identities = 72/241 (29%), Positives = 115/241 (47%), Gaps = 23/241 (9%)
Query: 79 LHLSVLFGHVECLLVLLDHNATINC-RPNGKTPLHVACEMANVDCVKILCDRGAKLNCYS 137
LH++ VLL ++ + G TPLH+A N++ ++L +RGA +N
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 138 LSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEH 197
+G T LH + +++ + L+ RGA + KT +DE TPLH AA G + ++H
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKT--KDELTPLHCAARNGHVRISEILLDH 294
Query: 198 GAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVC-RMLLDYKAEVNARDDDFKSPL 256
GA + + + +P+ +AA HL C R+LL Y AE++ D +PL
Sbjct: 295 GAPIQAKTKNGLSPIHMAA------------QGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Query: 257 HKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGA 316
H AA H + ++L+ GA+ N +NG + K VR +LLL GA
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR-------VMELLLKTGA 395
Query: 317 A 317
+
Sbjct: 396 S 396
Score = 93.2 bits (230), Expect = 4e-19
Identities = 73/243 (30%), Positives = 110/243 (45%), Gaps = 47/243 (19%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCV------------ 123
T LH + GHV +LLDH A I + NG +P+H+A + ++DCV
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 124 ---------------------KILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWR 162
K+L D+GAK N +L+G T LH + + + L+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 163 GANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRF 222
GA+++ T + TPLH A+ G +V ++ GA + N +ETPL +AA
Sbjct: 394 GASIDAVT--ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA------ 445
Query: 223 KEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMD 282
H V + LL KA+VNA+ D ++PLH AA ++ ++LE A NL
Sbjct: 446 -----RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 283 ING 285
G
Sbjct: 501 TAG 503
Score = 89.4 bits (220), Expect = 6e-18
Identities = 71/226 (31%), Positives = 105/226 (46%), Gaps = 14/226 (6%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ GH VLLD A N R NG TPLH+AC+ +V +++L GA ++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
+ SG T LH + + K L+ RGA+ N+ +N ETPLH AA G +E+ + +
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNV--SNVKVETPLHMAARAGHTEVAKYLL 457
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
++ A V++ +TPL AA H + ++LL+ A N +P
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAA-----------RIGHTNMVKLLLENNANPNLATTAGHTP 506
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPA 301
LH AA + +LE A M G + K VR A
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Score = 86.3 bits (212), Expect = 5e-17
Identities = 72/274 (26%), Positives = 120/274 (43%), Gaps = 52/274 (18%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ +G V +LL+ +A N NG TPLHVA N+D VK+L RG +
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFY- 194
+ +G+T LH + + A+ L+ G + N ++ TPLH AA G +E+VA
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES--VQGVTPLHLAAQEGHAEMVALLL 655
Query: 195 --------------------------------VEHGAIVDSVNAHMETPLAIAAYWALRF 222
++HG +VD+ TPL +A+++
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG--- 712
Query: 223 KEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMD 282
+ + + LL ++A+VNA+ SPLH+AA ++ ++L+ GA N +
Sbjct: 713 --------NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVS 764
Query: 283 INGCAAIQYV-----LKVTSVRPAAQPEICYQLL 311
+G + + VT V E + L+
Sbjct: 765 SDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLV 798
Score = 82.8 bits (203), Expect = 5e-16
Identities = 70/240 (29%), Positives = 102/240 (42%), Gaps = 21/240 (8%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH + GH + +LL++NA N G TPLH+A +V+ V L ++ A C
Sbjct: 472 TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 531
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
+ G T LH + A+ L+ R A+ N N TPLH A H ++V +
Sbjct: 532 MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN--GLTPLHVAVHHNNLDIVKLLL 589
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
G S + TPL IAA K+ + V R LL Y NA +P
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAA------KQNQVE-----VARSLLQYGGSANAESVQGVTP 638
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHG 315
LH AA ++ ++L A NL + +G + V + V A +L+ HG
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA-------DVLIKHG 691
Score = 67.4 bits (163), Expect = 2e-11
Identities = 64/230 (27%), Positives = 93/230 (40%), Gaps = 16/230 (6%)
Query: 74 SWATGLHLSVLFGHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAK 132
S T LH++ GH+ + LL A+ N +TPLH+A + + K L AK
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
+N + T LH K L+ AN N+ T TPLH AA G E V
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT--AGHTPLHIAAREGHVETVL 520
Query: 193 FYVEHGAIVDSVNAHMETPLAIAA-YWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDD 251
+E A + TPL +AA Y +R V +LL+ A NA +
Sbjct: 521 ALLEKEASQACMTKKGFTPLHVAAKYGKVR------------VAELLLERDAHPNAAGKN 568
Query: 252 FKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPA 301
+PLH A + + ++ ++L G + NG + K V A
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618
Score = 65.1 bits (157), Expect = 1e-10
Identities = 69/249 (27%), Positives = 103/249 (41%), Gaps = 25/249 (10%)
Query: 76 ATGLHLSVLFGHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAKLN 134
AT + G+++ L L + IN C NG LH+A + +V V L + L
Sbjct: 13 ATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72
Query: 135 CYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFY 194
+ G+TALH ++LV GANVN +Q TPL+ AA E+V F
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVN--AQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 195 VEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKS 254
+E+GA + TPLA+A H V L++Y + R
Sbjct: 131 LENGANQNVATEDGFTPLAVA-----------LQQGHENVVAHLINYGTKGKVR----LP 175
Query: 255 PLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNH 314
LH AA N D ++L+ +++ G + ++ A QLLLN
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA-------QLLLNR 228
Query: 315 GAARIYPPQ 323
GA+ + PQ
Sbjct: 229 GASVNFTPQ 237
Score = 51.6 bits (122), Expect = 1e-06
Identities = 41/143 (28%), Positives = 58/143 (40%), Gaps = 36/143 (25%)
Query: 74 SWATGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAK 132
S T LHL GHV VL+ H ++ G TPLHVA N+ VK L A
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD 726
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
+N + G+ +PLH AA G +++V
Sbjct: 727 VNAKTKLGY-----------------------------------SPLHQAAQQGHTDIVT 751
Query: 193 FYVEHGAIVDSVNAHMETPLAIA 215
+++GA + V++ TPLAIA
Sbjct: 752 LLLKNGASPNEVSSDGTTPLAIA 774
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 96.3 bits (238), Expect = 5e-20
Identities = 72/241 (29%), Positives = 115/241 (47%), Gaps = 23/241 (9%)
Query: 79 LHLSVLFGHVECLLVLLDHNATINC-RPNGKTPLHVACEMANVDCVKILCDRGAKLNCYS 137
LH++ VLL ++ + G TPLH+A N++ ++L +RGA +N
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 138 LSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEH 197
+G T LH + +++ + L+ RGA + KT +DE TPLH AA G + ++H
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKT--KDELTPLHCAARNGHVRISEILLDH 294
Query: 198 GAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVC-RMLLDYKAEVNARDDDFKSPL 256
GA + + + +P+ +AA HL C R+LL Y AE++ D +PL
Sbjct: 295 GAPIQAKTKNGLSPIHMAA------------QGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Query: 257 HKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGA 316
H AA H + ++L+ GA+ N +NG + K VR +LLL GA
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR-------VMELLLKTGA 395
Query: 317 A 317
+
Sbjct: 396 S 396
Score = 93.2 bits (230), Expect = 4e-19
Identities = 73/243 (30%), Positives = 110/243 (45%), Gaps = 47/243 (19%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCV------------ 123
T LH + GHV +LLDH A I + NG +P+H+A + ++DCV
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 124 ---------------------KILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWR 162
K+L D+GAK N +L+G T LH + + + L+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 163 GANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRF 222
GA+++ T + TPLH A+ G +V ++ GA + N +ETPL +AA
Sbjct: 394 GASIDAVT--ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA------ 445
Query: 223 KEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMD 282
H V + LL KA+VNA+ D ++PLH AA ++ ++LE A NL
Sbjct: 446 -----RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 283 ING 285
G
Sbjct: 501 TAG 503
Score = 89.4 bits (220), Expect = 6e-18
Identities = 71/226 (31%), Positives = 105/226 (46%), Gaps = 14/226 (6%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ GH VLLD A N R NG TPLH+AC+ +V +++L GA ++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
+ SG T LH + + K L+ RGA+ N+ +N ETPLH AA G +E+ + +
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNV--SNVKVETPLHMAARAGHTEVAKYLL 457
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
++ A V++ +TPL AA H + ++LL+ A N +P
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAA-----------RIGHTNMVKLLLENNANPNLATTAGHTP 506
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPA 301
LH AA + +LE A M G + K VR A
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Score = 86.3 bits (212), Expect = 5e-17
Identities = 72/274 (26%), Positives = 120/274 (43%), Gaps = 52/274 (18%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ +G V +LL+ +A N NG TPLHVA N+D VK+L RG +
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFY- 194
+ +G+T LH + + A+ L+ G + N ++ TPLH AA G +E+VA
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES--VQGVTPLHLAAQEGHAEMVALLL 655
Query: 195 --------------------------------VEHGAIVDSVNAHMETPLAIAAYWALRF 222
++HG +VD+ TPL +A+++
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG--- 712
Query: 223 KEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMD 282
+ + + LL ++A+VNA+ SPLH+AA ++ ++L+ GA N +
Sbjct: 713 --------NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVS 764
Query: 283 INGCAAIQYV-----LKVTSVRPAAQPEICYQLL 311
+G + + VT V E + L+
Sbjct: 765 SDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLV 798
Score = 82.8 bits (203), Expect = 5e-16
Identities = 70/240 (29%), Positives = 102/240 (42%), Gaps = 21/240 (8%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH + GH + +LL++NA N G TPLH+A +V+ V L ++ A C
Sbjct: 472 TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 531
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
+ G T LH + A+ L+ R A+ N N TPLH A H ++V +
Sbjct: 532 MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN--GLTPLHVAVHHNNLDIVKLLL 589
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
G S + TPL IAA K+ + V R LL Y NA +P
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAA------KQNQVE-----VARSLLQYGGSANAESVQGVTP 638
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHG 315
LH AA ++ ++L A NL + +G + V + V A +L+ HG
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA-------DVLIKHG 691
Score = 67.4 bits (163), Expect = 2e-11
Identities = 64/230 (27%), Positives = 93/230 (40%), Gaps = 16/230 (6%)
Query: 74 SWATGLHLSVLFGHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAK 132
S T LH++ GH+ + LL A+ N +TPLH+A + + K L AK
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
+N + T LH K L+ AN N+ T TPLH AA G E V
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT--AGHTPLHIAAREGHVETVL 520
Query: 193 FYVEHGAIVDSVNAHMETPLAIAA-YWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDD 251
+E A + TPL +AA Y +R V +LL+ A NA +
Sbjct: 521 ALLEKEASQACMTKKGFTPLHVAAKYGKVR------------VAELLLERDAHPNAAGKN 568
Query: 252 FKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPA 301
+PLH A + + ++ ++L G + NG + K V A
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618
Score = 65.1 bits (157), Expect = 1e-10
Identities = 69/249 (27%), Positives = 103/249 (41%), Gaps = 25/249 (10%)
Query: 76 ATGLHLSVLFGHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAKLN 134
AT + G+++ L L + IN C NG LH+A + +V V L + L
Sbjct: 13 ATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72
Query: 135 CYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFY 194
+ G+TALH ++LV GANVN +Q TPL+ AA E+V F
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVN--AQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 195 VEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKS 254
+E+GA + TPLA+A H V L++Y + R
Sbjct: 131 LENGANQNVATEDGFTPLAVA-----------LQQGHENVVAHLINYGTKGKVR----LP 175
Query: 255 PLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNH 314
LH AA N D ++L+ +++ G + ++ A QLLLN
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA-------QLLLNR 228
Query: 315 GAARIYPPQ 323
GA+ + PQ
Sbjct: 229 GASVNFTPQ 237
Score = 51.6 bits (122), Expect = 1e-06
Identities = 41/143 (28%), Positives = 58/143 (40%), Gaps = 36/143 (25%)
Query: 74 SWATGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAK 132
S T LHL GHV VL+ H ++ G TPLHVA N+ VK L A
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD 726
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
+N + G+ +PLH AA G +++V
Sbjct: 727 VNAKTKLGY-----------------------------------SPLHQAAQQGHTDIVT 751
Query: 193 FYVEHGAIVDSVNAHMETPLAIA 215
+++GA + V++ TPLAIA
Sbjct: 752 LLLKNGASPNEVSSDGTTPLAIA 774
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 96.3 bits (238), Expect = 5e-20
Identities = 72/241 (29%), Positives = 115/241 (47%), Gaps = 23/241 (9%)
Query: 79 LHLSVLFGHVECLLVLLDHNATINC-RPNGKTPLHVACEMANVDCVKILCDRGAKLNCYS 137
LH++ VLL ++ + G TPLH+A N++ ++L +RGA +N
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 138 LSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEH 197
+G T LH + +++ + L+ RGA + KT +DE TPLH AA G + ++H
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKT--KDELTPLHCAARNGHVRISEILLDH 294
Query: 198 GAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVC-RMLLDYKAEVNARDDDFKSPL 256
GA + + + +P+ +AA HL C R+LL Y AE++ D +PL
Sbjct: 295 GAPIQAKTKNGLSPIHMAA------------QGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Query: 257 HKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGA 316
H AA H + ++L+ GA+ N +NG + K VR +LLL GA
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR-------VMELLLKTGA 395
Query: 317 A 317
+
Sbjct: 396 S 396
Score = 93.2 bits (230), Expect = 4e-19
Identities = 73/243 (30%), Positives = 110/243 (45%), Gaps = 47/243 (19%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCV------------ 123
T LH + GHV +LLDH A I + NG +P+H+A + ++DCV
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 124 ---------------------KILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWR 162
K+L D+GAK N +L+G T LH + + + L+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 163 GANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRF 222
GA+++ T + TPLH A+ G +V ++ GA + N +ETPL +AA
Sbjct: 394 GASIDAVT--ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA------ 445
Query: 223 KEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMD 282
H V + LL KA+VNA+ D ++PLH AA ++ ++LE A NL
Sbjct: 446 -----RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 283 ING 285
G
Sbjct: 501 TAG 503
Score = 89.4 bits (220), Expect = 6e-18
Identities = 71/226 (31%), Positives = 105/226 (46%), Gaps = 14/226 (6%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ GH VLLD A N R NG TPLH+AC+ +V +++L GA ++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
+ SG T LH + + K L+ RGA+ N+ +N ETPLH AA G +E+ + +
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNV--SNVKVETPLHMAARAGHTEVAKYLL 457
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
++ A V++ +TPL AA H + ++LL+ A N +P
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAA-----------RIGHTNMVKLLLENNANPNLATTAGHTP 506
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPA 301
LH AA + +LE A M G + K VR A
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Score = 86.3 bits (212), Expect = 5e-17
Identities = 72/274 (26%), Positives = 120/274 (43%), Gaps = 52/274 (18%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ +G V +LL+ +A N NG TPLHVA N+D VK+L RG +
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFY- 194
+ +G+T LH + + A+ L+ G + N ++ TPLH AA G +E+VA
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES--VQGVTPLHLAAQEGHAEMVALLL 655
Query: 195 --------------------------------VEHGAIVDSVNAHMETPLAIAAYWALRF 222
++HG +VD+ TPL +A+++
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG--- 712
Query: 223 KEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMD 282
+ + + LL ++A+VNA+ SPLH+AA ++ ++L+ GA N +
Sbjct: 713 --------NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVS 764
Query: 283 INGCAAIQYV-----LKVTSVRPAAQPEICYQLL 311
+G + + VT V E + L+
Sbjct: 765 SDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLV 798
Score = 82.8 bits (203), Expect = 5e-16
Identities = 70/240 (29%), Positives = 102/240 (42%), Gaps = 21/240 (8%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH + GH + +LL++NA N G TPLH+A +V+ V L ++ A C
Sbjct: 472 TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 531
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
+ G T LH + A+ L+ R A+ N N TPLH A H ++V +
Sbjct: 532 MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN--GLTPLHVAVHHNNLDIVKLLL 589
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
G S + TPL IAA K+ + V R LL Y NA +P
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAA------KQNQVE-----VARSLLQYGGSANAESVQGVTP 638
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHG 315
LH AA ++ ++L A NL + +G + V + V A +L+ HG
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA-------DVLIKHG 691
Score = 67.4 bits (163), Expect = 2e-11
Identities = 64/230 (27%), Positives = 93/230 (40%), Gaps = 16/230 (6%)
Query: 74 SWATGLHLSVLFGHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAK 132
S T LH++ GH+ + LL A+ N +TPLH+A + + K L AK
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
+N + T LH K L+ AN N+ T TPLH AA G E V
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT--AGHTPLHIAAREGHVETVL 520
Query: 193 FYVEHGAIVDSVNAHMETPLAIAA-YWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDD 251
+E A + TPL +AA Y +R V +LL+ A NA +
Sbjct: 521 ALLEKEASQACMTKKGFTPLHVAAKYGKVR------------VAELLLERDAHPNAAGKN 568
Query: 252 FKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPA 301
+PLH A + + ++ ++L G + NG + K V A
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618
Score = 65.1 bits (157), Expect = 1e-10
Identities = 69/249 (27%), Positives = 103/249 (41%), Gaps = 25/249 (10%)
Query: 76 ATGLHLSVLFGHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAKLN 134
AT + G+++ L L + IN C NG LH+A + +V V L + L
Sbjct: 13 ATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72
Query: 135 CYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFY 194
+ G+TALH ++LV GANVN +Q TPL+ AA E+V F
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVN--AQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 195 VEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKS 254
+E+GA + TPLA+A H V L++Y + R
Sbjct: 131 LENGANQNVATEDGFTPLAVA-----------LQQGHENVVAHLINYGTKGKVR----LP 175
Query: 255 PLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNH 314
LH AA N D ++L+ +++ G + ++ A QLLLN
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA-------QLLLNR 228
Query: 315 GAARIYPPQ 323
GA+ + PQ
Sbjct: 229 GASVNFTPQ 237
Score = 51.6 bits (122), Expect = 1e-06
Identities = 41/143 (28%), Positives = 58/143 (40%), Gaps = 36/143 (25%)
Query: 74 SWATGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAK 132
S T LHL GHV VL+ H ++ G TPLHVA N+ VK L A
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD 726
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
+N + G+ +PLH AA G +++V
Sbjct: 727 VNAKTKLGY-----------------------------------SPLHQAAQQGHTDIVT 751
Query: 193 FYVEHGAIVDSVNAHMETPLAIA 215
+++GA + V++ TPLAIA
Sbjct: 752 LLLKNGASPNEVSSDGTTPLAIA 774
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 96.3 bits (238), Expect = 5e-20
Identities = 72/241 (29%), Positives = 115/241 (47%), Gaps = 23/241 (9%)
Query: 79 LHLSVLFGHVECLLVLLDHNATINC-RPNGKTPLHVACEMANVDCVKILCDRGAKLNCYS 137
LH++ VLL ++ + G TPLH+A N++ ++L +RGA +N
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 138 LSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEH 197
+G T LH + +++ + L+ RGA + KT +DE TPLH AA G + ++H
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKT--KDELTPLHCAARNGHVRISEILLDH 294
Query: 198 GAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVC-RMLLDYKAEVNARDDDFKSPL 256
GA + + + +P+ +AA HL C R+LL Y AE++ D +PL
Sbjct: 295 GAPIQAKTKNGLSPIHMAA------------QGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Query: 257 HKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGA 316
H AA H + ++L+ GA+ N +NG + K VR +LLL GA
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR-------VMELLLKTGA 395
Query: 317 A 317
+
Sbjct: 396 S 396
Score = 93.2 bits (230), Expect = 4e-19
Identities = 73/243 (30%), Positives = 110/243 (45%), Gaps = 47/243 (19%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCV------------ 123
T LH + GHV +LLDH A I + NG +P+H+A + ++DCV
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 124 ---------------------KILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWR 162
K+L D+GAK N +L+G T LH + + + L+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 163 GANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRF 222
GA+++ T + TPLH A+ G +V ++ GA + N +ETPL +AA
Sbjct: 394 GASIDAVT--ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA------ 445
Query: 223 KEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMD 282
H V + LL KA+VNA+ D ++PLH AA ++ ++LE A NL
Sbjct: 446 -----RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 283 ING 285
G
Sbjct: 501 TAG 503
Score = 89.4 bits (220), Expect = 6e-18
Identities = 71/226 (31%), Positives = 105/226 (46%), Gaps = 14/226 (6%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ GH VLLD A N R NG TPLH+AC+ +V +++L GA ++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
+ SG T LH + + K L+ RGA+ N+ +N ETPLH AA G +E+ + +
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNV--SNVKVETPLHMAARAGHTEVAKYLL 457
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
++ A V++ +TPL AA H + ++LL+ A N +P
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAA-----------RIGHTNMVKLLLENNANPNLATTAGHTP 506
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPA 301
LH AA + +LE A M G + K VR A
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Score = 86.3 bits (212), Expect = 5e-17
Identities = 72/274 (26%), Positives = 120/274 (43%), Gaps = 52/274 (18%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ +G V +LL+ +A N NG TPLHVA N+D VK+L RG +
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFY- 194
+ +G+T LH + + A+ L+ G + N ++ TPLH AA G +E+VA
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES--VQGVTPLHLAAQEGHAEMVALLL 655
Query: 195 --------------------------------VEHGAIVDSVNAHMETPLAIAAYWALRF 222
++HG +VD+ TPL +A+++
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYG--- 712
Query: 223 KEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMD 282
+ + + LL ++A+VNA+ SPLH+AA ++ ++L+ GA N +
Sbjct: 713 --------NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVS 764
Query: 283 INGCAAIQYV-----LKVTSVRPAAQPEICYQLL 311
+G + + VT V E + L+
Sbjct: 765 SDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLV 798
Score = 82.8 bits (203), Expect = 5e-16
Identities = 70/240 (29%), Positives = 102/240 (42%), Gaps = 21/240 (8%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH + GH + +LL++NA N G TPLH+A +V+ V L ++ A C
Sbjct: 472 TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 531
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
+ G T LH + A+ L+ R A+ N N TPLH A H ++V +
Sbjct: 532 MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN--GLTPLHVAVHHNNLDIVKLLL 589
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
G S + TPL IAA K+ + V R LL Y NA +P
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAA------KQNQVE-----VARSLLQYGGSANAESVQGVTP 638
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHG 315
LH AA ++ ++L A NL + +G + V + V A +L+ HG
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA-------DVLIKHG 691
Score = 67.4 bits (163), Expect = 2e-11
Identities = 64/230 (27%), Positives = 93/230 (40%), Gaps = 16/230 (6%)
Query: 74 SWATGLHLSVLFGHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAK 132
S T LH++ GH+ + LL A+ N +TPLH+A + + K L AK
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
+N + T LH K L+ AN N+ T TPLH AA G E V
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT--AGHTPLHIAAREGHVETVL 520
Query: 193 FYVEHGAIVDSVNAHMETPLAIAA-YWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDD 251
+E A + TPL +AA Y +R V +LL+ A NA +
Sbjct: 521 ALLEKEASQACMTKKGFTPLHVAAKYGKVR------------VAELLLERDAHPNAAGKN 568
Query: 252 FKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPA 301
+PLH A + + ++ ++L G + NG + K V A
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618
Score = 65.1 bits (157), Expect = 1e-10
Identities = 69/249 (27%), Positives = 103/249 (41%), Gaps = 25/249 (10%)
Query: 76 ATGLHLSVLFGHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAKLN 134
AT + G+++ L L + IN C NG LH+A + +V V L + L
Sbjct: 13 ATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72
Query: 135 CYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFY 194
+ G+TALH ++LV GANVN +Q TPL+ AA E+V F
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVN--AQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 195 VEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKS 254
+E+GA + TPLA+A H V L++Y + R
Sbjct: 131 LENGANQNVATEDGFTPLAVA-----------LQQGHENVVAHLINYGTKGKVR----LP 175
Query: 255 PLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNH 314
LH AA N D ++L+ +++ G + ++ A QLLLN
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA-------QLLLNR 228
Query: 315 GAARIYPPQ 323
GA+ + PQ
Sbjct: 229 GASVNFTPQ 237
Score = 51.6 bits (122), Expect = 1e-06
Identities = 41/143 (28%), Positives = 58/143 (40%), Gaps = 36/143 (25%)
Query: 74 SWATGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAK 132
S T LHL GHV VL+ H ++ G TPLHVA N+ VK L A
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQAD 726
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
+N + G+ +PLH AA G +++V
Sbjct: 727 VNAKTKLGY-----------------------------------SPLHQAAQQGHTDIVT 751
Query: 193 FYVEHGAIVDSVNAHMETPLAIA 215
+++GA + V++ TPLAIA
Sbjct: 752 LLLKNGASPNEVSSDGTTPLAIA 774
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 94.0 bits (232), Expect = 2e-19
Identities = 69/243 (28%), Positives = 112/243 (46%), Gaps = 20/243 (8%)
Query: 75 WATGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKL 133
W T LH +V E + VL+ H+A +N R N +TPLHVA V C +++ + +
Sbjct: 49 WLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSV 108
Query: 134 NCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAF 193
N G TALH + L+ +GAN+N ++ + LH AA+ G ++VA
Sbjct: 109 NVSDRGGRTALHHAALNGHVEMVNLLLAKGANIN--AFDKKDRRALHWAAYMGHLDVVAL 166
Query: 194 YVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFK 253
+ HGA V + TPL AA S V + LL+ E++ +
Sbjct: 167 LINHGAEVTCKDKKGYTPLHAAA-----------SNGQINVVKHLLNLGVEIDEINVYGN 215
Query: 254 SPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLN 313
+ LH A +N +++ +++ GA N + NG + + T +C +LL+N
Sbjct: 216 TALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAST------HGALCLELLVN 269
Query: 314 HGA 316
+GA
Sbjct: 270 NGA 272
Score = 87.0 bits (214), Expect = 3e-17
Identities = 65/210 (30%), Positives = 99/210 (47%), Gaps = 13/210 (6%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINC-RPNGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH + L GHVE + +LL A IN + LH A M ++D V +L + GA++ C
Sbjct: 117 TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC 176
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
G+T LH + I K L+ G ++ N T LH A + G +V +
Sbjct: 177 KDKKGYTPLHAAASNGQINVVKHLLNLGVEID--EINVYGNTALHIACYNGQDAVVNELI 234
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
++GA V+ N + TPL AA ST L +L++ A+VN + D KSP
Sbjct: 235 DYGANVNQPNNNGFTPLHFAAA----------STHGALCLELLVNNGADVNIQSKDGKSP 284
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDING 285
LH A + +++ G E + +D +G
Sbjct: 285 LHMTAVHGRFTRSQTLIQNGGEIDCVDKDG 314
Score = 82.0 bits (201), Expect = 9e-16
Identities = 60/214 (28%), Positives = 99/214 (46%), Gaps = 15/214 (7%)
Query: 74 SWATGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAK 132
+W T LH++ V+C V++ +++N G+T LH A +V+ V +L +GA
Sbjct: 81 NWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGAN 140
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
+N + ALH+ + L+ GA V K ++ TPLH AA G +V
Sbjct: 141 INAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK--DKKGYTPLHAAASNGQINVVK 198
Query: 193 FYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDF 252
+ G +D +N + T L IA Y V L+DY A VN +++
Sbjct: 199 HLLNLGVEIDEINVYGNTALHIACY-----------NGQDAVVNELIDYGANVNQPNNNG 247
Query: 253 KSPLHKAAWNCDHVL-MHMMLEAGAEANLMDING 285
+PLH AA + L + +++ GA+ N+ +G
Sbjct: 248 FTPLHFAAASTHGALCLELLVNNGADVNIQSKDG 281
Score = 79.7 bits (195), Expect = 5e-15
Identities = 67/230 (29%), Positives = 111/230 (48%), Gaps = 20/230 (8%)
Query: 50 VEDENMVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPN-GK 108
VE N++LA +G + ++ K A LH + GH++ + +L++H A + C+ G
Sbjct: 128 VEMVNLLLA---KGANINAFDKKDRRA--LHWAAYMGHLDVVALLINHGAEVTCKDKKGY 182
Query: 109 TPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNM 168
TPLH A ++ VK L + G +++ ++ G+TALH +L+ GANVN
Sbjct: 183 TPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQ 242
Query: 169 KTNNQDEETPLHTAAHFGLSEL-VAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEY 227
NN TPLH AA L + V +GA V+ + ++PL + A RF +
Sbjct: 243 PNNN--GFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHG-RFTRSQ- 298
Query: 228 STEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAE 277
L+ E++ D D +PLH AA +L++ + +GA+
Sbjct: 299 ---------TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD 339
Score = 68.6 bits (166), Expect = 1e-11
Identities = 67/259 (25%), Positives = 111/259 (42%), Gaps = 29/259 (11%)
Query: 79 LHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAKLNCYS 137
LHL+ L H +C LL I+ G+T LH A NV+C+K+L GA +
Sbjct: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410
Query: 138 LSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSE---LVAFY 194
G T LH+ C + LV GANVN + T LH AA + ++
Sbjct: 411 KCGRTPLHYAAANCHFHCIETLVTTGANVN--ETDDWGRTALHYAAASDMDRNKTILGNA 468
Query: 195 VEHGAIVDSVNAHMETPLAIAAYWALR------FKEQE-YSTEH------HLVCRMLLDY 241
++ ++ E + + L+ +++E Y++ H H C LL
Sbjct: 469 HDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLE 528
Query: 242 KAEVNARDDD---FKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSV 298
+ + D KSPLH AA+N H + ++L++ + ++ D G A L + +
Sbjct: 529 RTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTA----LDLAAF 584
Query: 299 RPAAQPEICYQLLLNHGAA 317
+ + C + L+N GA+
Sbjct: 585 KGHTE---CVEALINPGAS 600
Score = 59.7 bits (143), Expect = 5e-09
Identities = 57/222 (25%), Positives = 96/222 (43%), Gaps = 30/222 (13%)
Query: 67 PSYKLKSSWATGLHLSVLFGHVECLLVLLDH-NATINCRPNG--KTPLHVACEMANVDCV 123
PS + K + +H + +GH +CL +LL+ N+ +G K+PLH+A + +
Sbjct: 500 PSIRDKEGY-NSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQAL 558
Query: 124 KILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTA- 182
++L L+ G TAL C + L+ GA++ +K +N + TPLH +
Sbjct: 559 EVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVK-DNVTKRTPLHASV 617
Query: 183 --AHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWA-------LRFKEQEYSTEHHL 233
H L+ ++ VD +A +TPL +A + L KE T L
Sbjct: 618 INGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDIL 677
Query: 234 VC---------------RMLLDYKAEVNARDDDFKSPLHKAA 260
C +MLL+ + + +D ++PLH AA
Sbjct: 678 GCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA 719
Score = 59.7 bits (143), Expect = 5e-09
Identities = 69/245 (28%), Positives = 107/245 (43%), Gaps = 36/245 (14%)
Query: 77 TGLHLSVLFGHVECLLVLL---DHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAK 132
T LH SV+ GH CL +LL D+ ++ + G+TPL +A ++D V +L ++ A
Sbjct: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFG----LS 188
++ + G TALH C + L+ + ++ K + TPLH AA G LS
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSR--GRTPLHYAAARGHATWLS 728
Query: 189 ELVAFYVEHGAIVDSVNAHMETPLAIAAY--------------WALRFKEQEYSTEH--- 231
EL+ + N TPL A Y +F ++ H
Sbjct: 729 ELLQMALSEEDCCFKDNQGY-TPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAI 787
Query: 232 ---HLVCRMLLDYKAE---VNARDDDFKSPLHKAAWNCDHV-LMHMMLEAGAEANLMDIN 284
H C LL + V+ RDD ++PL AA+ DHV + ++L A N +D +
Sbjct: 788 INDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAF-ADHVECLQLLLRHSAPVNAVDNS 846
Query: 285 GCAAI 289
G A+
Sbjct: 847 GKTAL 851
Score = 55.1 bits (131), Expect = 1e-07
Identities = 53/204 (25%), Positives = 93/204 (45%), Gaps = 24/204 (11%)
Query: 108 KTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVN 167
+TPLHVA + + + +++L GA++N T LH S + L+ A+VN
Sbjct: 17 RTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVN 76
Query: 168 MKTNNQDEETPLHTAA---HFGLSELVAFYVEHGAIVD----------SVNAHMETPLAI 214
+ N +TPLH AA +E++ + + D ++N H+E +
Sbjct: 77 ARDKNW--QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 134
Query: 215 AAYWA--LRFKEQEYSTEH------HL-VCRMLLDYKAEVNARDDDFKSPLHKAAWNCDH 265
A A F +++ H HL V +L+++ AEV +D +PLH AA N
Sbjct: 135 LAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQI 194
Query: 266 VLMHMMLEAGAEANLMDINGCAAI 289
++ +L G E + +++ G A+
Sbjct: 195 NVVKHLLNLGVEIDEINVYGNTAL 218
Score = 52.4 bits (124), Expect = 8e-07
Identities = 36/140 (25%), Positives = 69/140 (49%), Gaps = 7/140 (5%)
Query: 77 TGLHLSVLFGHVECLLVLLD--HNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAKL 133
T LH +++ H C +LL ++ ++CR + G+TPL A +V+C+++L A +
Sbjct: 781 TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPV 840
Query: 134 NCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTA---AHFGLSEL 190
N SG TAL + A ++ A ++ ++D TPLH A H + L
Sbjct: 841 NAVDNSGKTAL-MMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALL 899
Query: 191 VAFYVEHGAIVDSVNAHMET 210
+ ++ ++++ N ++T
Sbjct: 900 ILDKIQDESLINEKNNALQT 919
Score = 52.0 bits (123), Expect = 1e-06
Identities = 36/125 (28%), Positives = 65/125 (52%), Gaps = 11/125 (8%)
Query: 167 NMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQE 226
++ T + ++ TPLH AA G +E++ + GA V++ + TPL A A R +E
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAV--ASRSEE-- 63
Query: 227 YSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGC 286
++L+ + A+VNARD ++++PLH AA N +++ + N+ D G
Sbjct: 64 -------AVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGR 116
Query: 287 AAIQY 291
A+ +
Sbjct: 117 TALHH 121
Score = 52.0 bits (123), Expect = 1e-06
Identities = 49/220 (22%), Positives = 85/220 (38%), Gaps = 48/220 (21%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPN------------------------------ 106
T LH ++ GH EC+ +LL+ +I C+ +
Sbjct: 680 TALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEED 739
Query: 107 -------GKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQL 159
G TPLH AC N +C+++L ++ + + T LH CA L
Sbjct: 740 CCFKDNQGYTPLHWACYNGNENCIEVLLEQKC-FRKFIGNPFTPLHCAIINDHGNCASLL 798
Query: 160 VWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWA 219
+ + + + TPL AA E + + H A V++V+ +T L +AA
Sbjct: 799 LGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAA--- 855
Query: 220 LRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKA 259
+ + V ++ +A++ +D D +PLH A
Sbjct: 856 -------ENGQAGAVDILVNSAQADLTVKDKDLNTPLHLA 888
Score = 45.8 bits (107), Expect = 7e-05
Identities = 58/271 (21%), Positives = 101/271 (37%), Gaps = 76/271 (28%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH + G+VEC+ +L A + + G+TPLH A + C++ L GA +N
Sbjct: 382 TCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNE 441
Query: 136 YSLSGHTALHFCTTPS----------------------------SILCAKQLVWRGANVN 167
G TALH+ + LC + L+ AN +
Sbjct: 442 TDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPS 501
Query: 168 MK--------------------------TNNQDEET-------PLHTAAHFGLSELVAFY 194
++ TN+ EE+ PLH AA+ G + +
Sbjct: 502 IRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVL 561
Query: 195 VEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVC-RMLLDYKAEVNARDDDFK 253
++ +D + T L +AA+ + H C L++ A + +D+ K
Sbjct: 562 LQSLVDLDIRDEKGRTALDLAAF------------KGHTECVEALINPGASIFVKDNVTK 609
Query: 254 -SPLHKAAWNCDHVLMHMMLEAGAEANLMDI 283
+PLH + N + + ++LE +D+
Sbjct: 610 RTPLHASVINGHTLCLRLLLEIADNPEAVDV 640
Score = 35.8 bits (81), Expect = 0.076
Identities = 28/109 (25%), Positives = 50/109 (45%), Gaps = 10/109 (9%)
Query: 237 MLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVT 296
ML+ +VN D + ++PLH AA+ D ++ +++ +GA N D + +
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAV--- 57
Query: 297 SVRPAAQPEICYQLLLNHGA---ARIYPPQFHKVIQACHSCPKAIEVVV 342
A++ E Q+L+ H A AR Q + A + K EV++
Sbjct: 58 ----ASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVII 102
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 92.4 bits (228), Expect = 7e-19
Identities = 77/262 (29%), Positives = 122/262 (46%), Gaps = 30/262 (11%)
Query: 29 DFGKLKAILIQRQIDVDTVFEVEDENMVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHV 88
D K A+L+Q + D V+ + MV + + G+ T LH++ +G+V
Sbjct: 182 DDTKSAALLLQNDHNAD----VQSKMMVNRTTESGF------------TPLHIAAHYGNV 225
Query: 89 ECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFC 147
+LL+ A ++ NG TPLHVA + N + VK+L DRG +++ + G T LH
Sbjct: 226 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 285
Query: 148 TTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAH 207
+ L+ RGA + +T N +PLH AA E V ++H A VD V
Sbjct: 286 ARSGHDQVVELLLERGAPLLARTKN--GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLD 343
Query: 208 METPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVL 267
T L +AA+ H+ V ++LLD +A NAR + +PLH A +
Sbjct: 344 YLTALHVAAHCG-----------HYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 392
Query: 268 MHMMLEAGAEANLMDINGCAAI 289
M ++++ GA + +G I
Sbjct: 393 MELLVKYGASIQAITESGLTPI 414
Score = 87.4 bits (215), Expect = 2e-17
Identities = 73/244 (29%), Positives = 114/244 (46%), Gaps = 21/244 (8%)
Query: 75 WATGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKL 133
+ T LH++ GH +LLD A N R NG TPLH+AC+ + +++L GA +
Sbjct: 344 YLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 403
Query: 134 NCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAF 193
+ SG T +H + L+ GA+ ++ N ET LH AA G E+V
Sbjct: 404 QAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV--TNIRGETALHMAARAGQVEVVRC 461
Query: 194 YVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFK 253
+ +GA+VD+ +TPL IA+ R + E + ++LL + A +A +
Sbjct: 462 LLRNGALVDARAREEQTPLHIAS----RLGKTE-------IVQLLLQHMAHPDAATTNGY 510
Query: 254 SPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLN 313
+PLH +A + ++LEAGA +L G + K S+ A +LLL
Sbjct: 511 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA-------KLLLQ 563
Query: 314 HGAA 317
AA
Sbjct: 564 RRAA 567
Score = 82.4 bits (202), Expect = 7e-16
Identities = 68/263 (25%), Positives = 122/263 (46%), Gaps = 32/263 (12%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINC-RPNGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ ++ + +L+ + A+I +G TP+HVA M +++ V +L GA +
Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
++ G TALH + + L+ GA V+ + ++E+TPLH A+ G +E+V +
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARA--REEQTPLHIASRLGKTEIVQLLL 496
Query: 196 EHGAIVDSVNAHMETPLAIAAY--------------WALRFKEQEYSTEHHL-------- 233
+H A D+ + TPL I+A A ++ T H+
Sbjct: 497 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 556
Query: 234 VCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVL 293
V ++LL +A ++ + +PLH AA + + ++LE GA + NG +
Sbjct: 557 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAA 616
Query: 294 KVTSVRPAAQPEICYQLLLNHGA 316
K ++ A+ LLN+GA
Sbjct: 617 KKNQMQIAS-------TLLNYGA 632
Score = 82.0 bits (201), Expect = 9e-16
Identities = 67/235 (28%), Positives = 112/235 (47%), Gaps = 29/235 (12%)
Query: 91 LLVLLDHNATINCR-------PNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTA 143
LL+ DHNA + + +G TPLH+A NV+ +L +RGA ++ + +G T
Sbjct: 189 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 248
Query: 144 LHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDS 203
LH + + K L+ RG ++ KT +D TPLH AA G ++V +E GA + +
Sbjct: 249 LHVASKRGNTNMVKLLLDRGGQIDAKT--RDGLTPLHCAARSGHDQVVELLLERGAPLLA 306
Query: 204 VNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNC 263
+ +PL +AA +H + LL +KA V+ D+ + LH AA +C
Sbjct: 307 RTKNGLSPLHMAA-----------QGDHVECVKHLLQHKAPVDDVTLDYLTALHVAA-HC 354
Query: 264 DHV-LMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAA 317
H + ++L+ A N +NG + K ++ +LL+ +GA+
Sbjct: 355 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIK-------VMELLVKYGAS 402
Score = 77.8 bits (190), Expect = 2e-14
Identities = 59/214 (27%), Positives = 100/214 (46%), Gaps = 14/214 (6%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ + + + L+LL+ A+ + NG TPLH+A + + L + GA+ N
Sbjct: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 636
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
+ G T LH + L+ +GAN++M T + T LH AA +
Sbjct: 637 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG--LTSLHLAAQEDKVNVADILT 694
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
+HGA D+ TPL +A ++ + + LL A VNA+ + +P
Sbjct: 695 KHGADQDAHTKLGYTPLIVACHYG-----------NVKMVNFLLKQGANVNAKTKNGYTP 743
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAI 289
LH+AA +++++L+ GA+ N NG A+
Sbjct: 744 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 777
Score = 75.5 bits (184), Expect = 9e-14
Identities = 53/162 (32%), Positives = 81/162 (50%), Gaps = 3/162 (1%)
Query: 55 MVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHV 113
M +AS Y + + T LHL+ GH + + +LLD A I+ +G T LH+
Sbjct: 621 MQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 680
Query: 114 ACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQ 173
A + V+ IL GA + ++ G+T L ++ L+ +GANVN KT N
Sbjct: 681 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 740
Query: 174 DEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIA 215
TPLH AA G + ++ ++HGA ++ A+ T LAIA
Sbjct: 741 --YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 780
Score = 65.1 bits (157), Expect = 1e-10
Identities = 62/243 (25%), Positives = 102/243 (41%), Gaps = 21/243 (8%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T L+++ H++ + LL++ A + +G TPL VA + + V IL + K
Sbjct: 111 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV 170
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEE--TPLHTAAHFGLSELVAF 193
+ H A T S+ L + M N E TPLH AAH+G +
Sbjct: 171 RLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATL 230
Query: 194 YVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFK 253
+ GA VD + TPL +A+ + + ++LLD +++A+ D
Sbjct: 231 LLNRGAAVDFTARNGITPLHVAS-----------KRGNTNMVKLLLDRGGQIDAKTRDGL 279
Query: 254 SPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLN 313
+PLH AA + ++ ++LE GA NG + + + V C + LL
Sbjct: 280 TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE-------CVKHLLQ 332
Query: 314 HGA 316
H A
Sbjct: 333 HKA 335
Score = 63.9 bits (154), Expect = 3e-10
Identities = 42/131 (32%), Positives = 68/131 (51%), Gaps = 3/131 (2%)
Query: 86 GHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTAL 144
G+++ ++ L IN C NG LH+A + +V V+ L RG+ ++ + G+TAL
Sbjct: 21 GNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTAL 80
Query: 145 HFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSV 204
H + K LV GAN+N +Q+ TPL+ AA ++V + +E+GA +
Sbjct: 81 HIASLAGQAEVVKVLVKEGANIN--AQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTA 138
Query: 205 NAHMETPLAIA 215
TPLA+A
Sbjct: 139 TEDGFTPLAVA 149
Score = 48.5 bits (114), Expect = 1e-05
Identities = 38/119 (31%), Positives = 49/119 (41%), Gaps = 3/119 (2%)
Query: 74 SWATGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAK 132
S T LHL+ V +L H A + G TPL VAC NV V L +GA
Sbjct: 673 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN 732
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELV 191
+N + +G+T LH L+ GA N T N + T L A G +V
Sbjct: 733 VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGN--TALAIAKRLGYISVV 789
Score = 47.0 bits (110), Expect = 3e-05
Identities = 42/161 (26%), Positives = 75/161 (46%), Gaps = 15/161 (9%)
Query: 114 ACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQ 173
A N+D V G +N + +G ALH + ++L+ RG++V+ T
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 174 DEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHL 233
+ T LH A+ G +E+V V+ GA +++ + + TPL +AA E+H+
Sbjct: 77 N--TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA------------QENHI 122
Query: 234 -VCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLE 273
V + LL+ A + +D +PL A + + ++LE
Sbjct: 123 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE 163
Score = 34.7 bits (78), Expect = 0.17
Identities = 33/129 (25%), Positives = 55/129 (42%), Gaps = 11/129 (8%)
Query: 166 VNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQ 225
+++ T NQ+ LH AA G LV + G+ VDS T L IA+
Sbjct: 34 IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASL-------- 85
Query: 226 EYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDING 285
V ++L+ A +NA+ + +PL+ AA ++ +LE GA + +G
Sbjct: 86 ---AGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 142
Query: 286 CAAIQYVLK 294
+ L+
Sbjct: 143 FTPLAVALQ 151
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 92.4 bits (228), Expect = 7e-19
Identities = 77/262 (29%), Positives = 122/262 (46%), Gaps = 30/262 (11%)
Query: 29 DFGKLKAILIQRQIDVDTVFEVEDENMVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHV 88
D K A+L+Q + D V+ + MV + + G+ T LH++ +G+V
Sbjct: 203 DDTKSAALLLQNDHNAD----VQSKMMVNRTTESGF------------TPLHIAAHYGNV 246
Query: 89 ECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFC 147
+LL+ A ++ NG TPLHVA + N + VK+L DRG +++ + G T LH
Sbjct: 247 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 306
Query: 148 TTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAH 207
+ L+ RGA + +T N +PLH AA E V ++H A VD V
Sbjct: 307 ARSGHDQVVELLLERGAPLLARTKN--GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLD 364
Query: 208 METPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVL 267
T L +AA+ H+ V ++LLD +A NAR + +PLH A +
Sbjct: 365 YLTALHVAAHCG-----------HYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 413
Query: 268 MHMMLEAGAEANLMDINGCAAI 289
M ++++ GA + +G I
Sbjct: 414 MELLVKYGASIQAITESGLTPI 435
Score = 87.4 bits (215), Expect = 2e-17
Identities = 73/244 (29%), Positives = 114/244 (46%), Gaps = 21/244 (8%)
Query: 75 WATGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKL 133
+ T LH++ GH +LLD A N R NG TPLH+AC+ + +++L GA +
Sbjct: 365 YLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 424
Query: 134 NCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAF 193
+ SG T +H + L+ GA+ ++ N ET LH AA G E+V
Sbjct: 425 QAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV--TNIRGETALHMAARAGQVEVVRC 482
Query: 194 YVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFK 253
+ +GA+VD+ +TPL IA+ R + E + ++LL + A +A +
Sbjct: 483 LLRNGALVDARAREEQTPLHIAS----RLGKTE-------IVQLLLQHMAHPDAATTNGY 531
Query: 254 SPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLN 313
+PLH +A + ++LEAGA +L G + K S+ A +LLL
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA-------KLLLQ 584
Query: 314 HGAA 317
AA
Sbjct: 585 RRAA 588
Score = 82.4 bits (202), Expect = 7e-16
Identities = 68/263 (25%), Positives = 122/263 (46%), Gaps = 32/263 (12%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINC-RPNGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ ++ + +L+ + A+I +G TP+HVA M +++ V +L GA +
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
++ G TALH + + L+ GA V+ + ++E+TPLH A+ G +E+V +
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARA--REEQTPLHIASRLGKTEIVQLLL 517
Query: 196 EHGAIVDSVNAHMETPLAIAAY--------------WALRFKEQEYSTEHHL-------- 233
+H A D+ + TPL I+A A ++ T H+
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 577
Query: 234 VCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVL 293
V ++LL +A ++ + +PLH AA + + ++LE GA + NG +
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAA 637
Query: 294 KVTSVRPAAQPEICYQLLLNHGA 316
K ++ A+ LLN+GA
Sbjct: 638 KKNQMQIAS-------TLLNYGA 653
Score = 82.0 bits (201), Expect = 9e-16
Identities = 67/235 (28%), Positives = 112/235 (47%), Gaps = 29/235 (12%)
Query: 91 LLVLLDHNATINCR-------PNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTA 143
LL+ DHNA + + +G TPLH+A NV+ +L +RGA ++ + +G T
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269
Query: 144 LHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDS 203
LH + + K L+ RG ++ KT +D TPLH AA G ++V +E GA + +
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKT--RDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
Query: 204 VNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNC 263
+ +PL +AA +H + LL +KA V+ D+ + LH AA +C
Sbjct: 328 RTKNGLSPLHMAA-----------QGDHVECVKHLLQHKAPVDDVTLDYLTALHVAA-HC 375
Query: 264 DHV-LMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAA 317
H + ++L+ A N +NG + K ++ +LL+ +GA+
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIK-------VMELLVKYGAS 423
Score = 77.8 bits (190), Expect = 2e-14
Identities = 59/214 (27%), Positives = 100/214 (46%), Gaps = 14/214 (6%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ + + + L+LL+ A+ + NG TPLH+A + + L + GA+ N
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
+ G T LH + L+ +GAN++M T + T LH AA +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG--LTSLHLAAQEDKVNVADILT 715
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
+HGA D+ TPL +A ++ + + LL A VNA+ + +P
Sbjct: 716 KHGADQDAHTKLGYTPLIVACHYG-----------NVKMVNFLLKQGANVNAKTKNGYTP 764
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAI 289
LH+AA +++++L+ GA+ N NG A+
Sbjct: 765 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Score = 75.5 bits (184), Expect = 9e-14
Identities = 53/162 (32%), Positives = 81/162 (50%), Gaps = 3/162 (1%)
Query: 55 MVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHV 113
M +AS Y + + T LHL+ GH + + +LLD A I+ +G T LH+
Sbjct: 642 MQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 701
Query: 114 ACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQ 173
A + V+ IL GA + ++ G+T L ++ L+ +GANVN KT N
Sbjct: 702 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 761
Query: 174 DEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIA 215
TPLH AA G + ++ ++HGA ++ A+ T LAIA
Sbjct: 762 --YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
Score = 65.1 bits (157), Expect = 1e-10
Identities = 62/243 (25%), Positives = 102/243 (41%), Gaps = 21/243 (8%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T L+++ H++ + LL++ A + +G TPL VA + + V IL + K
Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV 191
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEE--TPLHTAAHFGLSELVAF 193
+ H A T S+ L + M N E TPLH AAH+G +
Sbjct: 192 RLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATL 251
Query: 194 YVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFK 253
+ GA VD + TPL +A+ + + ++LLD +++A+ D
Sbjct: 252 LLNRGAAVDFTARNGITPLHVAS-----------KRGNTNMVKLLLDRGGQIDAKTRDGL 300
Query: 254 SPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLN 313
+PLH AA + ++ ++LE GA NG + + + V C + LL
Sbjct: 301 TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE-------CVKHLLQ 353
Query: 314 HGA 316
H A
Sbjct: 354 HKA 356
Score = 63.9 bits (154), Expect = 3e-10
Identities = 42/131 (32%), Positives = 68/131 (51%), Gaps = 3/131 (2%)
Query: 86 GHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTAL 144
G+++ ++ L IN C NG LH+A + +V V+ L RG+ ++ + G+TAL
Sbjct: 42 GNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTAL 101
Query: 145 HFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSV 204
H + K LV GAN+N +Q+ TPL+ AA ++V + +E+GA +
Sbjct: 102 HIASLAGQAEVVKVLVKEGANIN--AQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTA 159
Query: 205 NAHMETPLAIA 215
TPLA+A
Sbjct: 160 TEDGFTPLAVA 170
Score = 48.5 bits (114), Expect = 1e-05
Identities = 38/119 (31%), Positives = 49/119 (41%), Gaps = 3/119 (2%)
Query: 74 SWATGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAK 132
S T LHL+ V +L H A + G TPL VAC NV V L +GA
Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN 753
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELV 191
+N + +G+T LH L+ GA N T N + T L A G +V
Sbjct: 754 VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGN--TALAIAKRLGYISVV 810
Score = 47.0 bits (110), Expect = 3e-05
Identities = 42/161 (26%), Positives = 75/161 (46%), Gaps = 15/161 (9%)
Query: 114 ACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQ 173
A N+D V G +N + +G ALH + ++L+ RG++V+ T
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 174 DEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHL 233
+ T LH A+ G +E+V V+ GA +++ + + TPL +AA E+H+
Sbjct: 98 N--TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA------------QENHI 143
Query: 234 -VCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLE 273
V + LL+ A + +D +PL A + + ++LE
Sbjct: 144 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE 184
Score = 34.7 bits (78), Expect = 0.17
Identities = 33/129 (25%), Positives = 55/129 (42%), Gaps = 11/129 (8%)
Query: 166 VNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQ 225
+++ T NQ+ LH AA G LV + G+ VDS T L IA+
Sbjct: 55 IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASL-------- 106
Query: 226 EYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDING 285
V ++L+ A +NA+ + +PL+ AA ++ +LE GA + +G
Sbjct: 107 ---AGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 163
Query: 286 CAAIQYVLK 294
+ L+
Sbjct: 164 FTPLAVALQ 172
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 92.4 bits (228), Expect = 7e-19
Identities = 77/262 (29%), Positives = 122/262 (46%), Gaps = 30/262 (11%)
Query: 29 DFGKLKAILIQRQIDVDTVFEVEDENMVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHV 88
D K A+L+Q + D V+ + MV + + G+ T LH++ +G+V
Sbjct: 203 DDTKSAALLLQNDHNAD----VQSKMMVNRTTESGF------------TPLHIAAHYGNV 246
Query: 89 ECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFC 147
+LL+ A ++ NG TPLHVA + N + VK+L DRG +++ + G T LH
Sbjct: 247 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 306
Query: 148 TTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAH 207
+ L+ RGA + +T N +PLH AA E V ++H A VD V
Sbjct: 307 ARSGHDQVVELLLERGAPLLARTKN--GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLD 364
Query: 208 METPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVL 267
T L +AA+ H+ V ++LLD +A NAR + +PLH A +
Sbjct: 365 YLTALHVAAHCG-----------HYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 413
Query: 268 MHMMLEAGAEANLMDINGCAAI 289
M ++++ GA + +G I
Sbjct: 414 MELLVKYGASIQAITESGLTPI 435
Score = 87.4 bits (215), Expect = 2e-17
Identities = 73/244 (29%), Positives = 114/244 (46%), Gaps = 21/244 (8%)
Query: 75 WATGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKL 133
+ T LH++ GH +LLD A N R NG TPLH+AC+ + +++L GA +
Sbjct: 365 YLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 424
Query: 134 NCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAF 193
+ SG T +H + L+ GA+ ++ N ET LH AA G E+V
Sbjct: 425 QAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV--TNIRGETALHMAARAGQVEVVRC 482
Query: 194 YVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFK 253
+ +GA+VD+ +TPL IA+ R + E + ++LL + A +A +
Sbjct: 483 LLRNGALVDARAREEQTPLHIAS----RLGKTE-------IVQLLLQHMAHPDAATTNGY 531
Query: 254 SPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLN 313
+PLH +A + ++LEAGA +L G + K S+ A +LLL
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA-------KLLLQ 584
Query: 314 HGAA 317
AA
Sbjct: 585 RRAA 588
Score = 82.4 bits (202), Expect = 7e-16
Identities = 68/263 (25%), Positives = 122/263 (46%), Gaps = 32/263 (12%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINC-RPNGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ ++ + +L+ + A+I +G TP+HVA M +++ V +L GA +
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
++ G TALH + + L+ GA V+ + ++E+TPLH A+ G +E+V +
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARA--REEQTPLHIASRLGKTEIVQLLL 517
Query: 196 EHGAIVDSVNAHMETPLAIAAY--------------WALRFKEQEYSTEHHL-------- 233
+H A D+ + TPL I+A A ++ T H+
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 577
Query: 234 VCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVL 293
V ++LL +A ++ + +PLH AA + + ++LE GA + NG +
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAA 637
Query: 294 KVTSVRPAAQPEICYQLLLNHGA 316
K ++ A+ LLN+GA
Sbjct: 638 KKNQMQIAS-------TLLNYGA 653
Score = 82.0 bits (201), Expect = 9e-16
Identities = 67/235 (28%), Positives = 112/235 (47%), Gaps = 29/235 (12%)
Query: 91 LLVLLDHNATINCR-------PNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTA 143
LL+ DHNA + + +G TPLH+A NV+ +L +RGA ++ + +G T
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269
Query: 144 LHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDS 203
LH + + K L+ RG ++ KT +D TPLH AA G ++V +E GA + +
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKT--RDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
Query: 204 VNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNC 263
+ +PL +AA +H + LL +KA V+ D+ + LH AA +C
Sbjct: 328 RTKNGLSPLHMAA-----------QGDHVECVKHLLQHKAPVDDVTLDYLTALHVAA-HC 375
Query: 264 DHV-LMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAA 317
H + ++L+ A N +NG + K ++ +LL+ +GA+
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIK-------VMELLVKYGAS 423
Score = 77.8 bits (190), Expect = 2e-14
Identities = 59/214 (27%), Positives = 100/214 (46%), Gaps = 14/214 (6%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ + + + L+LL+ A+ + NG TPLH+A + + L + GA+ N
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
+ G T LH + L+ +GAN++M T + T LH AA +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG--LTSLHLAAQEDKVNVADILT 715
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
+HGA D+ TPL +A ++ + + LL A VNA+ + +P
Sbjct: 716 KHGADQDAHTKLGYTPLIVACHYG-----------NVKMVNFLLKQGANVNAKTKNGYTP 764
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAI 289
LH+AA +++++L+ GA+ N NG A+
Sbjct: 765 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Score = 75.5 bits (184), Expect = 9e-14
Identities = 53/162 (32%), Positives = 81/162 (50%), Gaps = 3/162 (1%)
Query: 55 MVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHV 113
M +AS Y + + T LHL+ GH + + +LLD A I+ +G T LH+
Sbjct: 642 MQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 701
Query: 114 ACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQ 173
A + V+ IL GA + ++ G+T L ++ L+ +GANVN KT N
Sbjct: 702 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 761
Query: 174 DEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIA 215
TPLH AA G + ++ ++HGA ++ A+ T LAIA
Sbjct: 762 --YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
Score = 65.1 bits (157), Expect = 1e-10
Identities = 62/243 (25%), Positives = 102/243 (41%), Gaps = 21/243 (8%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T L+++ H++ + LL++ A + +G TPL VA + + V IL + K
Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV 191
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEE--TPLHTAAHFGLSELVAF 193
+ H A T S+ L + M N E TPLH AAH+G +
Sbjct: 192 RLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATL 251
Query: 194 YVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFK 253
+ GA VD + TPL +A+ + + ++LLD +++A+ D
Sbjct: 252 LLNRGAAVDFTARNGITPLHVAS-----------KRGNTNMVKLLLDRGGQIDAKTRDGL 300
Query: 254 SPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLN 313
+PLH AA + ++ ++LE GA NG + + + V C + LL
Sbjct: 301 TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE-------CVKHLLQ 353
Query: 314 HGA 316
H A
Sbjct: 354 HKA 356
Score = 63.9 bits (154), Expect = 3e-10
Identities = 42/131 (32%), Positives = 68/131 (51%), Gaps = 3/131 (2%)
Query: 86 GHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTAL 144
G+++ ++ L IN C NG LH+A + +V V+ L RG+ ++ + G+TAL
Sbjct: 42 GNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTAL 101
Query: 145 HFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSV 204
H + K LV GAN+N +Q+ TPL+ AA ++V + +E+GA +
Sbjct: 102 HIASLAGQAEVVKVLVKEGANIN--AQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTA 159
Query: 205 NAHMETPLAIA 215
TPLA+A
Sbjct: 160 TEDGFTPLAVA 170
Score = 48.5 bits (114), Expect = 1e-05
Identities = 38/119 (31%), Positives = 49/119 (41%), Gaps = 3/119 (2%)
Query: 74 SWATGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAK 132
S T LHL+ V +L H A + G TPL VAC NV V L +GA
Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN 753
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELV 191
+N + +G+T LH L+ GA N T N + T L A G +V
Sbjct: 754 VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGN--TALAIAKRLGYISVV 810
Score = 47.0 bits (110), Expect = 3e-05
Identities = 42/161 (26%), Positives = 75/161 (46%), Gaps = 15/161 (9%)
Query: 114 ACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQ 173
A N+D V G +N + +G ALH + ++L+ RG++V+ T
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 174 DEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHL 233
+ T LH A+ G +E+V V+ GA +++ + + TPL +AA E+H+
Sbjct: 98 N--TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA------------QENHI 143
Query: 234 -VCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLE 273
V + LL+ A + +D +PL A + + ++LE
Sbjct: 144 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE 184
Score = 34.7 bits (78), Expect = 0.17
Identities = 33/129 (25%), Positives = 55/129 (42%), Gaps = 11/129 (8%)
Query: 166 VNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQ 225
+++ T NQ+ LH AA G LV + G+ VDS T L IA+
Sbjct: 55 IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASL-------- 106
Query: 226 EYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDING 285
V ++L+ A +NA+ + +PL+ AA ++ +LE GA + +G
Sbjct: 107 ---AGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 163
Query: 286 CAAIQYVLK 294
+ L+
Sbjct: 164 FTPLAVALQ 172
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 91.7 bits (226), Expect = 1e-18
Identities = 67/230 (29%), Positives = 107/230 (46%), Gaps = 14/230 (6%)
Query: 66 LPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVK 124
+P + + + T LH++ GH + VLLD A N + NG TPLH+AC+ + ++
Sbjct: 358 VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVME 417
Query: 125 ILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAH 184
+L GA + + SG T +H + QL+ GA+ N T N ET LH AA
Sbjct: 418 LLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPN--TTNVRGETALHMAAR 475
Query: 185 FGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAE 244
G +E+V + V+ GA V++ +TPL I+A R + + + + LL A
Sbjct: 476 SGQAEVVRYLVQDGAQVEAKAKDDQTPLHISA----RLGKAD-------IVQQLLQQGAS 524
Query: 245 VNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLK 294
NA +PLH +A + +L+ GA ++ G + K
Sbjct: 525 PNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK 574
Score = 88.6 bits (218), Expect = 1e-17
Identities = 71/242 (29%), Positives = 111/242 (45%), Gaps = 21/242 (8%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ +G++ +LL+ A ++ N TPLHVA + N + VK+L DRGAK++
Sbjct: 237 TPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDA 296
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
+ G T LH + L+ R A + KT N +PLH A V +
Sbjct: 297 KTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKN--GLSPLHMATQGDHLNCVQLLL 354
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
+H VD V T L +AA+ H+ V ++LLD KA NA+ + +P
Sbjct: 355 QHNVPVDDVTNDYLTALHVAAHCG-----------HYKVAKVLLDKKANPNAKALNGFTP 403
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHG 315
LH A +M ++L+ GA + +G I + V +Q L++HG
Sbjct: 404 LHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQ-------LMHHG 456
Query: 316 AA 317
A+
Sbjct: 457 AS 458
Score = 87.8 bits (216), Expect = 2e-17
Identities = 61/217 (28%), Positives = 103/217 (47%), Gaps = 14/217 (6%)
Query: 74 SWATGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAK 132
S T LH++ + + + L+LLD A+ + NG TPLH+A + +D L + GA
Sbjct: 597 SGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD 656
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
N + G ++H + L+ R ANVN+ +N+ TPLH AA +
Sbjct: 657 ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNL--SNKSGLTPLHLAAQEDRVNVAE 714
Query: 193 FYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDF 252
V GA VD+ TPL + ++ + + LL + A+VNA+ +
Sbjct: 715 VLVNQGAHVDAQTKMGYTPLHVGCHYG-----------NIKIVNFLLQHSAKVNAKTKNG 763
Query: 253 KSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAI 289
+PLH+AA +++++L+ A N + +NG A+
Sbjct: 764 YTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTAL 800
Score = 77.4 bits (189), Expect = 2e-14
Identities = 63/229 (27%), Positives = 110/229 (48%), Gaps = 25/229 (10%)
Query: 91 LLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTP 150
LL+ D+NA + + +G TPLH+A N++ +L +R A ++ + + T LH +
Sbjct: 220 LLLQNDNNADVESK-SGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKR 278
Query: 151 SSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMET 210
+ K L+ RGA ++ KT +D TPLH A G ++V ++ A + S + +
Sbjct: 279 GNANMVKLLLDRGAKIDAKT--RDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS 336
Query: 211 PLAIAAYWALRFKEQEYSTEHHLVC-RMLLDYKAEVNARDDDFKSPLHKAAWNCDHV-LM 268
PL +A + HL C ++LL + V+ +D+ + LH AA +C H +
Sbjct: 337 PLHMA------------TQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAA-HCGHYKVA 383
Query: 269 HMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAA 317
++L+ A N +NG + K ++ +LLL HGA+
Sbjct: 384 KVLLDKKANPNAKALNGFTPLHIACKKNRIK-------VMELLLKHGAS 425
Score = 73.2 bits (178), Expect = 4e-13
Identities = 63/241 (26%), Positives = 104/241 (43%), Gaps = 21/241 (8%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH+S G + + LL A+ N +G TPLH++ + D L D GA L+
Sbjct: 501 TPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI 560
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
+ G T LH + A L+ + A+ + + TPLH AAH+ ++ +
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPD--AAGKSGLTPLHVAAHYDNQKVALLLL 618
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
+ GA + + TPL IAA K+ + + LL+Y A+ NA +
Sbjct: 619 DQGASPHAAAKNGYTPLHIAA------KKNQMD-----IATTLLEYGADANAVTRQGIAS 667
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHG 315
+H AA ++ ++L A NL + +G + + V A ++L+N G
Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVA-------EVLVNQG 720
Query: 316 A 316
A
Sbjct: 721 A 721
Score = 71.6 bits (174), Expect = 1e-12
Identities = 44/138 (31%), Positives = 73/138 (52%), Gaps = 3/138 (2%)
Query: 79 LHLSVLFGHVECLLVLLDHNATINC-RPNGKTPLHVACEMANVDCVKILCDRGAKLNCYS 137
+HL+ GHV+ + +LL NA +N +G TPLH+A + V+ ++L ++GA ++ +
Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 727
Query: 138 LSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEH 197
G+T LH +I L+ A VN KT N TPLH AA G + ++ +++
Sbjct: 728 KMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKN--GYTPLHQAAQQGHTHIINVLLQN 785
Query: 198 GAIVDSVNAHMETPLAIA 215
A + + + T L IA
Sbjct: 786 NASPNELTVNGNTALGIA 803
Score = 70.1 bits (170), Expect = 4e-12
Identities = 66/233 (28%), Positives = 98/233 (42%), Gaps = 25/233 (10%)
Query: 86 GHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTAL 144
GH+E L + + IN C NG LH+A + +V+ V L R A ++ + G+TAL
Sbjct: 52 GHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTAL 111
Query: 145 HFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSV 204
H + K LV GANVN +Q+ TPL+ AA E+V F +++GA
Sbjct: 112 HIASLAGQAEVVKVLVTNGANVN--AQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLA 169
Query: 205 NAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCD 264
TPLA+A H V +LL+ + R LH AA D
Sbjct: 170 TEDGFTPLAVA-----------LQQGHDQVVSLLLENDTKGKVR----LPALHIAARKDD 214
Query: 265 HVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAA 317
++L+ A++ +G + ++ A LLLN AA
Sbjct: 215 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVAT-------LLLNRAAA 260
Score = 69.7 bits (169), Expect = 5e-12
Identities = 72/288 (25%), Positives = 119/288 (41%), Gaps = 61/288 (21%)
Query: 79 LHLSVLFGHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYS 137
LHL+ GHVE + LL A ++ G T LH+A + VK+L GA +N S
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137
Query: 138 LSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEH 197
+G T L+ + + K L+ GA+ ++ T +D TPL A G ++V+ +E+
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGASQSLAT--EDGFTPLAVALQQGHDQVVSLLLEN 195
Query: 198 GA------------------------IVDSVNAHME-----TPLAIAAYW---------- 218
+ + NA +E TPL IAA++
Sbjct: 196 DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLL 255
Query: 219 ----ALRFKEQEYSTEHHL--------VCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHV 266
A+ F + T H+ + ++LLD A+++A+ D +PLH A +
Sbjct: 256 NRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQ 315
Query: 267 LMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNH 314
++ M+L+ A NG + + + + C QLLL H
Sbjct: 316 VVEMLLDRAAPILSKTKNGLSPLHMATQGDHLN-------CVQLLLQH 356
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 90.9 bits (224), Expect = 2e-18
Identities = 83/287 (28%), Positives = 134/287 (46%), Gaps = 30/287 (10%)
Query: 11 SGAAKLVKRNFLEALKSNDFGKLKAILIQ-RQIDVDTVFEVEDENMVLASYKQGYWLPSY 69
+ A + R+ EA D ++ +LI+ R ++ T E E+++ + GY+ +
Sbjct: 228 ANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTE---EGESLLCLACSAGYYELAQ 284
Query: 70 KLKSSWA-----------TGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEM 117
L + A T L + GHV+ + +LL H A +N + + G T L AC
Sbjct: 285 VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344
Query: 118 ANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEET 177
VD VK+L + GA + ++ +GHT L + + A+ L+ GA +N +N+ +E+
Sbjct: 345 GYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH-SNEFKES 403
Query: 178 PLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRM 237
L A + G E+V F +E GA + M T L A H V R+
Sbjct: 404 ALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEAC-----------MDGHVEVARL 452
Query: 238 LLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDIN 284
LLD A+VN D F+SPL AA L +++E G A+L ++N
Sbjct: 453 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG--ASLEEVN 497
Score = 66.2 bits (160), Expect = 5e-11
Identities = 58/206 (28%), Positives = 98/206 (47%), Gaps = 14/206 (6%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPNGK--TPLHVACEMANVDCVKILCDRGAKLN 134
T L L+ GHV + +LLD+ A I + TPL +AC + V++L RGA
Sbjct: 1118 TPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKE 1177
Query: 135 CYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFY 194
++S +T L + + K L+ GA +N +T ++ +PL AA G + V
Sbjct: 1178 HRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 1237
Query: 195 VEHGAIVDS-VNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFK 253
++ G+ +++ + + T L +A + + TE V +LLD KA V R
Sbjct: 1238 LDMGSDINAQIETNRNTALTLACF--------QGRTE---VVSLLLDRKANVEHRAKTGL 1286
Query: 254 SPLHKAAWNCDHVLMHMMLEAGAEAN 279
+PL +AA + ++L+ GA+ N
Sbjct: 1287 TPLMEAASGGYAEVGRVLLDKGADVN 1312
Score = 65.5 bits (158), Expect = 9e-11
Identities = 61/205 (29%), Positives = 96/205 (46%), Gaps = 20/205 (9%)
Query: 86 GHVECLLVLLDHNATINCRPNG--KTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTA 143
GHVE +LL++ A IN N ++ L +AC +++ V+ L + GA + HTA
Sbjct: 378 GHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTA 437
Query: 144 LHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDS 203
L + A+ L+ GA VNM ++ E+PL AA G EL A +E GA ++
Sbjct: 438 LMEACMDGHVEVARLLLDSGAQVNMPADSF--ESPLTLAACGGHVELAALLIERGASLEE 495
Query: 204 VNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDF-KSPLHKAAWN 262
VN TPL AA H + +LL A +NA+ ++ ++ L A
Sbjct: 496 VNDEGYTPLMEAA-----------REGHEEMVALLLGQGANINAQTEETQETALTLACCG 544
Query: 263 CDHVLMHMMLEAGAEANLMDINGCA 287
+ +++AGA+ L GC+
Sbjct: 545 GFLEVADFLIKAGADIEL----GCS 565
Score = 60.8 bits (146), Expect = 2e-09
Identities = 60/213 (28%), Positives = 99/213 (46%), Gaps = 21/213 (9%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPNGK---TPLHVACEMANVDCVKILCDRGAKL 133
T L L+ G+V + +LL+ A IN R K +PL +A + VK+L D G+ +
Sbjct: 1185 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDI 1244
Query: 134 NCY-SLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
N + +TAL L+ R ANV + TPL AA G +E+
Sbjct: 1245 NAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG--LTPLMEAASGGYAEVGR 1302
Query: 193 FYVEHGAIVDS--VNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDD 250
++ GA V++ V + +T L IAA H+ C +L+ A ++ R+
Sbjct: 1303 VLLDKGADVNAPPVPSSRDTALTIAA-----------DKGHYKFCELLIGRGAHIDVRNK 1351
Query: 251 DFKSPLHKAAWNCDHV-LMHMMLEAGAEANLMD 282
+PL AA N H+ ++ ++++AGA+ + D
Sbjct: 1352 KGNTPLWLAA-NGGHLDVVQLLVQAGADVDAAD 1383
Score = 59.3 bits (142), Expect = 6e-09
Identities = 75/307 (24%), Positives = 115/307 (37%), Gaps = 56/307 (18%)
Query: 49 EVEDENMVLASYKQGYWLPSYKLKSS---------WATGLHLSVLFGHVECLLVLLDHNA 99
E ++ + LA YK + + L++ T L + + GHVE +LLD A
Sbjct: 399 EFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 458
Query: 100 TINCRPNG-KTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQ 158
+N + ++PL +A +V+ +L +RGA L + G+T L
Sbjct: 459 QVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVAL 518
Query: 159 LVWRGANVNMKTNNQDE-----------------------------ETPLHTAAHFGLSE 189
L+ +GAN+N +T E TPL AA G E
Sbjct: 519 LLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLE 578
Query: 190 LVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARD 249
LV + + GA V + A +T L A H V +LL A++
Sbjct: 579 LVKYLLAAGANVHATTATGDTALTYAC-----------ENGHTDVADVLLQAGADLEHES 627
Query: 250 DDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQ 309
+ ++PL KAA + ++ GA N N V S+ A +
Sbjct: 628 EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT------VLSLACAGGHLAVVE 681
Query: 310 LLLNHGA 316
LLL HGA
Sbjct: 682 LLLAHGA 688
Score = 58.5 bits (140), Expect = 1e-08
Identities = 54/190 (28%), Positives = 85/190 (44%), Gaps = 14/190 (7%)
Query: 79 LHLSVLFGHVECLLVLLDHNATINCR--PNGKTPLHVACEMANVDCVKILCDRGAKLNCY 136
L L+ + GH + +LLD + IN + N T L +AC + V +L DR A +
Sbjct: 1222 LMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHR 1281
Query: 137 SLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVE 196
+ +G T L + + L+ +GA+VN +T L AA G + +
Sbjct: 1282 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIG 1341
Query: 197 HGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPL 256
GA +D N TPL +AA + H V ++L+ A+V+A D+ +PL
Sbjct: 1342 RGAHIDVRNKKGNTPLWLAA-----------NGGHLDVVQLLVQAGADVDAADNRKITPL 1390
Query: 257 HKAAWNCDHV 266
AA+ HV
Sbjct: 1391 -MAAFRKGHV 1399
Score = 57.8 bits (138), Expect = 2e-08
Identities = 48/176 (27%), Positives = 82/176 (46%), Gaps = 14/176 (7%)
Query: 106 NGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGAN 165
N T L +AC + + V+ L +RGA + G T L T + + L+ GA+
Sbjct: 1082 NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD 1141
Query: 166 VNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQ 225
+ + + + ++TPL A G E+V + GA + N TPL++AA
Sbjct: 1142 IEAQ-SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA--------- 1191
Query: 226 EYSTEHHLVCRMLLDYKAEVNARDDDFK--SPLHKAAWNCDHVLMHMMLEAGAEAN 279
S + + ++LL+ AE+N+R SPL AA N + ++L+ G++ N
Sbjct: 1192 --SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN 1245
Score = 43.1 bits (100), Expect = 5e-04
Identities = 63/244 (25%), Positives = 103/244 (42%), Gaps = 34/244 (13%)
Query: 32 KLKAILIQRQIDVDTVFEVEDEN--------------MVLASYKQGYWLPSYKLKSSWAT 77
+L A+LI+R ++ EV DE MV QG + + + + + T
Sbjct: 481 ELAALLIERGASLE---EVNDEGYTPLMEAAREGHEEMVALLLGQGANINA-QTEETQET 536
Query: 78 GLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYS 137
L L+ G +E L+ A I TPL A + +++ VK L GA ++ +
Sbjct: 537 ALTLACCGGFLEVADFLIKAGADIEL--GCSTPLMEAAQEGHLELVKYLLAAGANVHATT 594
Query: 138 LSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEH 197
+G TAL + A L+ GA +++ ++ TPL AA G V F +
Sbjct: 595 ATGDTALTYACENGHTDVADVLLQAGA--DLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
Query: 198 GAIVDSVNAHME-TPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPL 256
GA V+ A+ + T L++A + H V +LL + A+ R D + L
Sbjct: 653 GANVNRTTANNDHTVLSLAC-----------AGGHLAVVELLLAHGADPTHRLKDGSTML 701
Query: 257 HKAA 260
+AA
Sbjct: 702 IEAA 705
Score = 29.6 bits (65), Expect = 5.5
Identities = 43/179 (24%), Positives = 74/179 (41%), Gaps = 21/179 (11%)
Query: 139 SGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHG 198
S + +L + + ++L+ G +VN T ++ E+ L A G EL +
Sbjct: 233 SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHT--EEGESLLCLACSAGYYELAQVLLAMH 290
Query: 199 AIVDSVNAHME-TPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLH 257
A V+ + TPL AA + H + ++LL +KA+VNA+ + L
Sbjct: 291 ANVEDRGIKGDITPLMAAA-----------NGGHVKIVKLLLAHKADVNAQSSTGNTALT 339
Query: 258 KAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGA 316
A ++ ++LE+GA + NG + V A +LLL +GA
Sbjct: 340 YACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVA-------RLLLENGA 391
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 90.9 bits (224), Expect = 2e-18
Identities = 83/287 (28%), Positives = 134/287 (46%), Gaps = 30/287 (10%)
Query: 11 SGAAKLVKRNFLEALKSNDFGKLKAILIQ-RQIDVDTVFEVEDENMVLASYKQGYWLPSY 69
+ A + R+ EA D ++ +LI+ R ++ T E E+++ + GY+ +
Sbjct: 228 ANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTE---EGESLLCLACSAGYYELAQ 284
Query: 70 KLKSSWA-----------TGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEM 117
L + A T L + GHV+ + +LL H A +N + + G T L AC
Sbjct: 285 VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344
Query: 118 ANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEET 177
VD VK+L + GA + ++ +GHT L + + A+ L+ GA +N +N+ +E+
Sbjct: 345 GYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTH-SNEFKES 403
Query: 178 PLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRM 237
L A + G E+V F +E GA + M T L A H V R+
Sbjct: 404 ALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEAC-----------MDGHVEVARL 452
Query: 238 LLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDIN 284
LLD A+VN D F+SPL AA L +++E G A+L ++N
Sbjct: 453 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG--ASLEEVN 497
Score = 66.2 bits (160), Expect = 5e-11
Identities = 58/206 (28%), Positives = 98/206 (47%), Gaps = 14/206 (6%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPNGK--TPLHVACEMANVDCVKILCDRGAKLN 134
T L L+ GHV + +LLD+ A I + TPL +AC + V++L RGA
Sbjct: 867 TPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKE 926
Query: 135 CYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFY 194
++S +T L + + K L+ GA +N +T ++ +PL AA G + V
Sbjct: 927 HRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLL 986
Query: 195 VEHGAIVDS-VNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFK 253
++ G+ +++ + + T L +A + + TE V +LLD KA V R
Sbjct: 987 LDMGSDINAQIETNRNTALTLACF--------QGRTE---VVSLLLDRKANVEHRAKTGL 1035
Query: 254 SPLHKAAWNCDHVLMHMMLEAGAEAN 279
+PL +AA + ++L+ GA+ N
Sbjct: 1036 TPLMEAASGGYAEVGRVLLDKGADVN 1061
Score = 65.5 bits (158), Expect = 9e-11
Identities = 61/205 (29%), Positives = 96/205 (46%), Gaps = 20/205 (9%)
Query: 86 GHVECLLVLLDHNATINCRPNG--KTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTA 143
GHVE +LL++ A IN N ++ L +AC +++ V+ L + GA + HTA
Sbjct: 378 GHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTA 437
Query: 144 LHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDS 203
L + A+ L+ GA VNM ++ E+PL AA G EL A +E GA ++
Sbjct: 438 LMEACMDGHVEVARLLLDSGAQVNMPADSF--ESPLTLAACGGHVELAALLIERGASLEE 495
Query: 204 VNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDF-KSPLHKAAWN 262
VN TPL AA H + +LL A +NA+ ++ ++ L A
Sbjct: 496 VNDEGYTPLMEAA-----------REGHEEMVALLLGQGANINAQTEETQETALTLACCG 544
Query: 263 CDHVLMHMMLEAGAEANLMDINGCA 287
+ +++AGA+ L GC+
Sbjct: 545 GFLEVADFLIKAGADIEL----GCS 565
Score = 60.8 bits (146), Expect = 2e-09
Identities = 60/213 (28%), Positives = 99/213 (46%), Gaps = 21/213 (9%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPNGK---TPLHVACEMANVDCVKILCDRGAKL 133
T L L+ G+V + +LL+ A IN R K +PL +A + VK+L D G+ +
Sbjct: 934 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDI 993
Query: 134 NCY-SLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
N + +TAL L+ R ANV + TPL AA G +E+
Sbjct: 994 NAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG--LTPLMEAASGGYAEVGR 1051
Query: 193 FYVEHGAIVDS--VNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDD 250
++ GA V++ V + +T L IAA H+ C +L+ A ++ R+
Sbjct: 1052 VLLDKGADVNAPPVPSSRDTALTIAA-----------DKGHYKFCELLIGRGAHIDVRNK 1100
Query: 251 DFKSPLHKAAWNCDHV-LMHMMLEAGAEANLMD 282
+PL AA N H+ ++ ++++AGA+ + D
Sbjct: 1101 KGNTPLWLAA-NGGHLDVVQLLVQAGADVDAAD 1132
Score = 59.3 bits (142), Expect = 6e-09
Identities = 75/307 (24%), Positives = 115/307 (37%), Gaps = 56/307 (18%)
Query: 49 EVEDENMVLASYKQGYWLPSYKLKSS---------WATGLHLSVLFGHVECLLVLLDHNA 99
E ++ + LA YK + + L++ T L + + GHVE +LLD A
Sbjct: 399 EFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 458
Query: 100 TINCRPNG-KTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQ 158
+N + ++PL +A +V+ +L +RGA L + G+T L
Sbjct: 459 QVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVAL 518
Query: 159 LVWRGANVNMKTNNQDE-----------------------------ETPLHTAAHFGLSE 189
L+ +GAN+N +T E TPL AA G E
Sbjct: 519 LLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLE 578
Query: 190 LVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARD 249
LV + + GA V + A +T L A H V +LL A++
Sbjct: 579 LVKYLLAAGANVHATTATGDTALTYAC-----------ENGHTDVADVLLQAGADLEHES 627
Query: 250 DDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQ 309
+ ++PL KAA + ++ GA N N V S+ A +
Sbjct: 628 EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT------VLSLACAGGHLAVVE 681
Query: 310 LLLNHGA 316
LLL HGA
Sbjct: 682 LLLAHGA 688
Score = 58.5 bits (140), Expect = 1e-08
Identities = 54/190 (28%), Positives = 85/190 (44%), Gaps = 14/190 (7%)
Query: 79 LHLSVLFGHVECLLVLLDHNATINCR--PNGKTPLHVACEMANVDCVKILCDRGAKLNCY 136
L L+ + GH + +LLD + IN + N T L +AC + V +L DR A +
Sbjct: 971 LMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHR 1030
Query: 137 SLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVE 196
+ +G T L + + L+ +GA+VN +T L AA G + +
Sbjct: 1031 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIG 1090
Query: 197 HGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPL 256
GA +D N TPL +AA + H V ++L+ A+V+A D+ +PL
Sbjct: 1091 RGAHIDVRNKKGNTPLWLAA-----------NGGHLDVVQLLVQAGADVDAADNRKITPL 1139
Query: 257 HKAAWNCDHV 266
AA+ HV
Sbjct: 1140 -MAAFRKGHV 1148
Score = 57.8 bits (138), Expect = 2e-08
Identities = 48/176 (27%), Positives = 82/176 (46%), Gaps = 14/176 (7%)
Query: 106 NGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGAN 165
N T L +AC + + V+ L +RGA + G T L T + + L+ GA+
Sbjct: 831 NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD 890
Query: 166 VNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQ 225
+ + + + ++TPL A G E+V + GA + N TPL++AA
Sbjct: 891 IEAQ-SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA--------- 940
Query: 226 EYSTEHHLVCRMLLDYKAEVNARDDDFK--SPLHKAAWNCDHVLMHMMLEAGAEAN 279
S + + ++LL+ AE+N+R SPL AA N + ++L+ G++ N
Sbjct: 941 --SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN 994
Score = 43.1 bits (100), Expect = 5e-04
Identities = 63/244 (25%), Positives = 103/244 (42%), Gaps = 34/244 (13%)
Query: 32 KLKAILIQRQIDVDTVFEVEDEN--------------MVLASYKQGYWLPSYKLKSSWAT 77
+L A+LI+R ++ EV DE MV QG + + + + + T
Sbjct: 481 ELAALLIERGASLE---EVNDEGYTPLMEAAREGHEEMVALLLGQGANINA-QTEETQET 536
Query: 78 GLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYS 137
L L+ G +E L+ A I TPL A + +++ VK L GA ++ +
Sbjct: 537 ALTLACCGGFLEVADFLIKAGADIEL--GCSTPLMEAAQEGHLELVKYLLAAGANVHATT 594
Query: 138 LSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEH 197
+G TAL + A L+ GA +++ ++ TPL AA G V F +
Sbjct: 595 ATGDTALTYACENGHTDVADVLLQAGA--DLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
Query: 198 GAIVDSVNAHME-TPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPL 256
GA V+ A+ + T L++A + H V +LL + A+ R D + L
Sbjct: 653 GANVNRTTANNDHTVLSLAC-----------AGGHLAVVELLLAHGADPTHRLKDGSTML 701
Query: 257 HKAA 260
+AA
Sbjct: 702 IEAA 705
Score = 29.6 bits (65), Expect = 5.5
Identities = 43/179 (24%), Positives = 74/179 (41%), Gaps = 21/179 (11%)
Query: 139 SGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHG 198
S + +L + + ++L+ G +VN T ++ E+ L A G EL +
Sbjct: 233 SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHT--EEGESLLCLACSAGYYELAQVLLAMH 290
Query: 199 AIVDSVNAHME-TPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLH 257
A V+ + TPL AA + H + ++LL +KA+VNA+ + L
Sbjct: 291 ANVEDRGIKGDITPLMAAA-----------NGGHVKIVKLLLAHKADVNAQSSTGNTALT 339
Query: 258 KAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGA 316
A ++ ++LE+GA + NG + V A +LLL +GA
Sbjct: 340 YACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVA-------RLLLENGA 391
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 88.6 bits (218), Expect = 1e-17
Identities = 59/188 (31%), Positives = 85/188 (45%), Gaps = 13/188 (6%)
Query: 106 NGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGAN 165
NG++P H+A +C+ IL GA +N + G TALH T C K L+ GAN
Sbjct: 53 NGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGAN 112
Query: 166 VNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQ 225
+ + + +PLH AA G + V +H A +D ++ TPL IA+
Sbjct: 113 ED--AVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGG------ 164
Query: 226 EYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDING 285
H +C LL A VN D + KS L A + ++L GA+A +D G
Sbjct: 165 -----HAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTG 219
Query: 286 CAAIQYVL 293
A+ Y L
Sbjct: 220 HDALHYAL 227
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 87.4 bits (215), Expect = 2e-17
Identities = 64/210 (30%), Positives = 100/210 (47%), Gaps = 13/210 (6%)
Query: 74 SWATGLHLSVLFGHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAK 132
S + LH +V GH+E + +LL+ A++N C + PLH A + +++ +K+L RGA
Sbjct: 139 SGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGAD 198
Query: 133 LNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
L C G+ LH I K L+ GA ++ N T LH A + G +
Sbjct: 199 LGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEID--EPNAFGNTALHIACYLGQDAVAI 256
Query: 193 FYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDF 252
V GA V+ N TPL +AA ST L +L++ A+VN + +
Sbjct: 257 ELVNAGANVNQPNDKGFTPLHVAA----------VSTNGALCLELLVNNGADVNYQSKEG 306
Query: 253 KSPLHKAAWNCDHVLMHMMLEAGAEANLMD 282
KSPLH AA + ++++ G+E + D
Sbjct: 307 KSPLHMAAIHGRFTRSQILIQNGSEIDCAD 336
Score = 68.2 bits (165), Expect = 1e-11
Identities = 56/221 (25%), Positives = 96/221 (43%), Gaps = 12/221 (5%)
Query: 90 CLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCT 148
CL +L+++ A +N + GK+PLH+A +IL G++++C G+T LH
Sbjct: 288 CLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAA 347
Query: 149 TPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHM 208
L L+ GA+ + + PLH A FG S+ + G + S+ + +
Sbjct: 348 RYGHELLISTLMTNGADTARR--GIHDMFPLHLAVLFGFSDCCRKLLSSGQLY-SIVSSL 404
Query: 209 ETPLAIAAYWALRFKEQEYSTEHHLVC--------RMLLDYKAEVNARDDDFKSPLHKAA 260
++A + + + T H +LL A++ RD ++PLH AA
Sbjct: 405 SNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAA 464
Query: 261 WNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPA 301
N + ++ AGA N D GC+ + Y + R A
Sbjct: 465 ANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRA 505
Score = 67.8 bits (164), Expect = 2e-11
Identities = 58/218 (26%), Positives = 96/218 (44%), Gaps = 17/218 (7%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T L L+++ GHV+C+ +LL+ +T + G+T LH DC+ L D A + C
Sbjct: 690 TPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLC 749
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEE--TPLHTAAHFGLSELVAF 193
G T +H + + L+ + + D +P+H A++ G + +
Sbjct: 750 RDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLEL 809
Query: 194 YVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAE--VNARDDD 251
+EH + + TPL A Q+ +TE MLL VN+RD
Sbjct: 810 LLEHSPF-SYLEGNPFTPLHCAV-----INNQDSTTE------MLLGALGAKIVNSRDAK 857
Query: 252 FKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAI 289
++PLH AA+ + + M+L+ AE N D G A+
Sbjct: 858 GRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTAL 895
Score = 57.0 bits (136), Expect = 3e-08
Identities = 66/286 (23%), Positives = 101/286 (35%), Gaps = 61/286 (21%)
Query: 79 LHLSVLFGHVECLLVLLDHNAT------------------INCRPN-GKTPLHVACEMAN 119
LHL+VLFG +C LL IN N G+T LH A N
Sbjct: 376 LHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGN 435
Query: 120 VDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVN------------ 167
V+C+ +L GA L G T LH+ S CA LV GA VN
Sbjct: 436 VECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHY 495
Query: 168 --------------MKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLA 213
+++ +E+ PL + + F +++GA + T +
Sbjct: 496 AAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVH 555
Query: 214 IAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLE 273
AA Y +L + + + + SPLH AA+N + + E
Sbjct: 556 YAA---------AYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAE 606
Query: 274 AGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARI 319
++ D G A+ + S C ++L HGA+ +
Sbjct: 607 TLVNLDVRDHKGRTALFLATERGSTE-------CVEVLTAHGASAL 645
Score = 57.0 bits (136), Expect = 3e-08
Identities = 50/193 (25%), Positives = 90/193 (46%), Gaps = 24/193 (12%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPNGKT-----PLHVACEMANVDCVKILCDRGA 131
T +H + +G+ + L +LL+ + NC + ++ PLH+A + + +K L +
Sbjct: 552 TAVHYAAAYGNRQNLELLLE--MSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLV 609
Query: 132 KLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELV 191
L+ G TAL T S C + L GA+ +K + + TPLH AA G ++ +
Sbjct: 610 NLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR-KWTPLHAAAASGHTDSL 668
Query: 192 AFYVEHGA---IVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVC-RMLLDYKAEVNA 247
++ G I D ++A+ +TPL +A H+ C +LL+ + +A
Sbjct: 669 HLLIDSGERADITDVMDAYGQTPLMLAI------------MNGHVDCVHLLLEKGSTADA 716
Query: 248 RDDDFKSPLHKAA 260
D ++ LH+ A
Sbjct: 717 ADLRGRTALHRGA 729
Score = 52.8 bits (125), Expect = 6e-07
Identities = 57/215 (26%), Positives = 92/215 (42%), Gaps = 23/215 (10%)
Query: 79 LHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVK--ILCDRGAKL-NC 135
+H + GH +CL +LL+H+ N TPLH A + N D +L GAK+ N
Sbjct: 795 MHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAV-INNQDSTTEMLLGALGAKIVNS 853
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
G T LH ++ + L+ A VN + T L TAA G + V F +
Sbjct: 854 RDAKGRTPLHAAAFADNVSGLRMLLQHQAEVN--ATDHTGRTALMTAAENGQTAAVEFLL 911
Query: 196 EHG-AIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAE----VNARDD 250
G A + ++ + T L +A ++ H C +++ + + +NA +
Sbjct: 912 YRGKADLTVLDENKNTALHLAC------------SKGHEKCALMILAETQDLGLINATNS 959
Query: 251 DFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDING 285
+ PLH AA N ++ +L GA +D G
Sbjct: 960 ALQMPLHIAARNGLASVVQALLSHGATVLAVDEEG 994
Score = 52.4 bits (124), Expect = 8e-07
Identities = 42/151 (27%), Positives = 71/151 (47%), Gaps = 18/151 (11%)
Query: 167 NMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQE 226
N+ +Q+ TPLH AA+ G ++ + GA V++ + TPL AA
Sbjct: 33 NINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAA---------- 82
Query: 227 YSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGC 286
++ + V +LL + A+VNARD +++PLH AA N + + N+ D +G
Sbjct: 83 -ASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGR 141
Query: 287 AAIQYVLKVTSVRPAAQPEICYQLLLNHGAA 317
+A+ + + + LLLN GA+
Sbjct: 142 SALHHAVHSGHLETV-------NLLLNKGAS 165
Score = 50.1 bits (118), Expect = 4e-06
Identities = 51/204 (25%), Positives = 88/204 (43%), Gaps = 18/204 (8%)
Query: 67 PSYKLKSSWATGLHLSVLFGH---VECLLVLLDHNATINCRPNGKTPLHVACEMANVDCV 123
P L+ + T LH +V+ E LL L + G+TPLH A NV +
Sbjct: 815 PFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGL 874
Query: 124 KILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTA- 182
++L A++N +G TAL + L++RG ++ ++++ T LH A
Sbjct: 875 RMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG-KADLTVLDENKNTALHLAC 933
Query: 183 --AHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLD 240
H + ++ + ++++ N+ ++ PL IAA L V + LL
Sbjct: 934 SKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLA-----------SVVQALLS 982
Query: 241 YKAEVNARDDDFKSPLHKAAWNCD 264
+ A V A D++ +P A N D
Sbjct: 983 HGATVLAVDEEGHTPALACAPNKD 1006
Score = 46.6 bits (109), Expect = 4e-05
Identities = 50/198 (25%), Positives = 81/198 (40%), Gaps = 24/198 (12%)
Query: 110 PLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMK 169
PL A +V+ V+ L + +N T LH + + L+ GANVN K
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 170 TNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAA------------- 216
TPLH AA +++ + H A V++ + +TPL +AA
Sbjct: 71 DTLW--LTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAP 128
Query: 217 -YWALRFKEQE-YSTEHHLV-------CRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVL 267
+L ++ S HH V +LL+ A +N D + PLH AA+ +
Sbjct: 129 LLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEV 188
Query: 268 MHMMLEAGAEANLMDING 285
+ +++ GA+ D G
Sbjct: 189 LKLLVARGADLGCKDRKG 206
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 86.3 bits (212), Expect = 5e-17
Identities = 69/241 (28%), Positives = 111/241 (46%), Gaps = 25/241 (10%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ FGHV + +L A ++ + N +TPLH+A E V ++ L GA +
Sbjct: 496 TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDA 555
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
SG+ LH L K L+ GA++ + T+ TPLH AA+ G E++
Sbjct: 556 LDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQG--WTPLHLAAYKGHLEIIHLLA 613
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRF--------------KEQEYSTEHHLVCRM---- 237
E A + ++ A TPL +AA EQ T HL +
Sbjct: 614 ESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFL 673
Query: 238 ----LLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVL 293
LL++ A V+AR+ +P H AA + ++ +++EAGA+ ++ D C +Q L
Sbjct: 674 SVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLAL 733
Query: 294 K 294
+
Sbjct: 734 R 734
Score = 73.9 bits (180), Expect = 3e-13
Identities = 65/246 (26%), Positives = 106/246 (43%), Gaps = 21/246 (8%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH V G VE + +LL H ++C+ +G TPL +A + D +L GA N
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
G LHF A+ L+ GA V+ ++ TPLH AA + V
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVD--AQEREGWTPLHLAAQNNFENVARLLV 481
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
A + A +TPL +AAY+ H + ++L AE++A+ + ++P
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFG-----------HVSLVKLLTSQGAELDAQQRNLRTP 530
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHG 315
LH A + +L++GA + +D +G + A + ++LL +G
Sbjct: 531 LHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLH-------TAAARGKYLICKMLLRYG 583
Query: 316 AARIYP 321
A+ P
Sbjct: 584 ASLELP 589
Score = 70.1 bits (170), Expect = 4e-12
Identities = 59/215 (27%), Positives = 94/215 (43%), Gaps = 15/215 (6%)
Query: 72 KSSWATGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRG 130
+ W T LHL+ +L+ A N GKTPLHVA +V VK+L +G
Sbjct: 459 REGW-TPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQG 517
Query: 131 AKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSEL 190
A+L+ + T LH + + L+ GA + +Q PLHTAA G +
Sbjct: 518 AELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPD--ALDQSGYGPLHTAAARGKYLI 575
Query: 191 VAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDD 250
+ +GA ++ TPL +AAY H + +L + A + A
Sbjct: 576 CKMLLRYGASLELPTHQGWTPLHLAAY-----------KGHLEIIHLLAESHANMGALGA 624
Query: 251 DFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDING 285
+PLH AA + + ++ +L+ GA+ N + +G
Sbjct: 625 VNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
Score = 65.9 bits (159), Expect = 7e-11
Identities = 50/179 (27%), Positives = 78/179 (43%), Gaps = 13/179 (7%)
Query: 106 NGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGAN 165
N TPLH +V+ V++L ++C + SG+T L L+ GA+
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
Query: 166 VNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQ 225
N ++D PLH AA G ++HGA VD+ TPL +AA
Sbjct: 421 ANRV--DEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAA--------- 469
Query: 226 EYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDIN 284
V R+L+ +A+ N + + K+PLH AA+ L+ ++ GAE + N
Sbjct: 470 --QNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRN 526
Score = 47.8 bits (112), Expect = 2e-05
Identities = 36/113 (31%), Positives = 53/113 (46%), Gaps = 11/113 (9%)
Query: 173 QDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHH 232
+++ TPLH G E V + H VD A TPL IAA Q+ +
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAA--------QDQQPD-- 409
Query: 233 LVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDING 285
+C +LL + A+ N D+D +PLH AA N D ++L+ GA + + G
Sbjct: 410 -LCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREG 461
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 84.7 bits (208), Expect = 1e-16
Identities = 80/285 (28%), Positives = 133/285 (46%), Gaps = 30/285 (10%)
Query: 13 AAKLVKRNFLEALKSNDFGKLKAILIQ-RQIDVDTVFEVEDENMVLASYKQGYWLPSYKL 71
A ++ R+ EA D ++ +L + R ++ T E E+++ + GY+ + L
Sbjct: 201 AGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE---EGESLLCLACSAGYYELAQVL 257
Query: 72 KSSWA-----------TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMAN 119
+ A T L + G+++ + +LL H+A +N + G T L AC
Sbjct: 258 LAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 317
Query: 120 VDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPL 179
VD VK+L + GA + ++ +GHT L + + A+ L+ GA +N +N + +E+ L
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN-EFKESAL 376
Query: 180 HTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLL 239
A + G ++V F +E GA + M T L A H V R+LL
Sbjct: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM-----------DGHVEVARLLL 425
Query: 240 DYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDIN 284
D A+VN D F+SPL AA L +++E G ANL ++N
Sbjct: 426 DSGAQVNMPADSFESPLTLAACGGHVELAALLIERG--ANLEEVN 468
Score = 72.4 bits (176), Expect = 7e-13
Identities = 65/205 (31%), Positives = 96/205 (46%), Gaps = 20/205 (9%)
Query: 86 GHVECLLVLLDHNATINCRPNG--KTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTA 143
GHVE VLLDH A IN N ++ L +AC ++D V+ L + GA + HTA
Sbjct: 349 GHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTA 408
Query: 144 LHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDS 203
L + A+ L+ GA VNM ++ E+PL AA G EL A +E GA ++
Sbjct: 409 LMEACMDGHVEVARLLLDSGAQVNMPADSF--ESPLTLAACGGHVELAALLIERGANLEE 466
Query: 204 VNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDF-KSPLHKAAWN 262
VN TPL AA H + +LL A +NA+ ++ ++ L A
Sbjct: 467 VNDEGYTPLMEAA-----------REGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
Query: 263 CDHVLMHMMLEAGAEANLMDINGCA 287
+ +++AGA+ L GC+
Sbjct: 516 GFSEVADFLIKAGADIEL----GCS 536
Score = 48.1 bits (113), Expect = 1e-05
Identities = 51/204 (25%), Positives = 80/204 (39%), Gaps = 41/204 (20%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPNG-KTPLHVACEMANVDCVKILCDRGAKLNC 135
T L + + GHVE +LLD A +N + ++PL +A +V+ +L +RGA L
Sbjct: 407 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE 466
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDE-------------------- 175
+ G+T L L+ +GAN+N +T E
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIK 526
Query: 176 ---------ETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQE 226
TPL A+ G ELV + + GA V + A +T L A
Sbjct: 527 AGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC---------- 576
Query: 227 YSTEHHLVCRMLLDYKAEVNARDD 250
H V +LL A+++ ++D
Sbjct: 577 -ENGHTDVADVLLQAGADLDKQED 599
Score = 29.6 bits (65), Expect = 5.5
Identities = 38/150 (25%), Positives = 64/150 (42%), Gaps = 20/150 (13%)
Query: 32 KLKAILIQRQIDVDTVFEVEDEN--------------MVLASYKQGYWLPSYKLKSSWAT 77
+L A+LI+R +++ EV DE MV QG + + + + + T
Sbjct: 452 ELAALLIERGANLE---EVNDEGYTPLMEAAREGHEEMVALLLAQGANINA-QTEETQET 507
Query: 78 GLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYS 137
L L+ G E L+ A I TPL A + +++ VK L GA ++ +
Sbjct: 508 ALTLACCGGFSEVADFLIKAGADIEL--GCSTPLMEASQEGHLELVKYLLASGANVHATT 565
Query: 138 LSGHTALHFCTTPSSILCAKQLVWRGANVN 167
+G TAL + A L+ GA+++
Sbjct: 566 ATGDTALTYACENGHTDVADVLLQAGADLD 595
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 84.7 bits (208), Expect = 1e-16
Identities = 80/285 (28%), Positives = 133/285 (46%), Gaps = 30/285 (10%)
Query: 13 AAKLVKRNFLEALKSNDFGKLKAILIQ-RQIDVDTVFEVEDENMVLASYKQGYWLPSYKL 71
A ++ R+ EA D ++ +L + R ++ T E E+++ + GY+ + L
Sbjct: 190 AGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE---EGESLLCLACSAGYYELAQVL 246
Query: 72 KSSWA-----------TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMAN 119
+ A T L + G+++ + +LL H+A +N + G T L AC
Sbjct: 247 LAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 306
Query: 120 VDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPL 179
VD VK+L + GA + ++ +GHT L + + A+ L+ GA +N +N + +E+ L
Sbjct: 307 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN-EFKESAL 365
Query: 180 HTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLL 239
A + G ++V F +E GA + M T L A H V R+LL
Sbjct: 366 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM-----------DGHVEVARLLL 414
Query: 240 DYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDIN 284
D A+VN D F+SPL AA L +++E G ANL ++N
Sbjct: 415 DSGAQVNMPADSFESPLTLAACGGHVELAALLIERG--ANLEEVN 457
Score = 72.4 bits (176), Expect = 7e-13
Identities = 65/205 (31%), Positives = 96/205 (46%), Gaps = 20/205 (9%)
Query: 86 GHVECLLVLLDHNATINCRPNG--KTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTA 143
GHVE VLLDH A IN N ++ L +AC ++D V+ L + GA + HTA
Sbjct: 338 GHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTA 397
Query: 144 LHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDS 203
L + A+ L+ GA VNM ++ E+PL AA G EL A +E GA ++
Sbjct: 398 LMEACMDGHVEVARLLLDSGAQVNMPADSF--ESPLTLAACGGHVELAALLIERGANLEE 455
Query: 204 VNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDF-KSPLHKAAWN 262
VN TPL AA H + +LL A +NA+ ++ ++ L A
Sbjct: 456 VNDEGYTPLMEAA-----------REGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
Query: 263 CDHVLMHMMLEAGAEANLMDINGCA 287
+ +++AGA+ L GC+
Sbjct: 505 GFSEVADFLIKAGADIEL----GCS 525
Score = 48.1 bits (113), Expect = 1e-05
Identities = 51/204 (25%), Positives = 80/204 (39%), Gaps = 41/204 (20%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPNG-KTPLHVACEMANVDCVKILCDRGAKLNC 135
T L + + GHVE +LLD A +N + ++PL +A +V+ +L +RGA L
Sbjct: 396 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE 455
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDE-------------------- 175
+ G+T L L+ +GAN+N +T E
Sbjct: 456 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIK 515
Query: 176 ---------ETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQE 226
TPL A+ G ELV + + GA V + A +T L A
Sbjct: 516 AGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC---------- 565
Query: 227 YSTEHHLVCRMLLDYKAEVNARDD 250
H V +LL A+++ ++D
Sbjct: 566 -ENGHTDVADVLLQAGADLDKQED 588
Score = 29.6 bits (65), Expect = 5.5
Identities = 38/150 (25%), Positives = 64/150 (42%), Gaps = 20/150 (13%)
Query: 32 KLKAILIQRQIDVDTVFEVEDEN--------------MVLASYKQGYWLPSYKLKSSWAT 77
+L A+LI+R +++ EV DE MV QG + + + + + T
Sbjct: 441 ELAALLIERGANLE---EVNDEGYTPLMEAAREGHEEMVALLLAQGANINA-QTEETQET 496
Query: 78 GLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYS 137
L L+ G E L+ A I TPL A + +++ VK L GA ++ +
Sbjct: 497 ALTLACCGGFSEVADFLIKAGADIEL--GCSTPLMEASQEGHLELVKYLLASGANVHATT 554
Query: 138 LSGHTALHFCTTPSSILCAKQLVWRGANVN 167
+G TAL + A L+ GA+++
Sbjct: 555 ATGDTALTYACENGHTDVADVLLQAGADLD 584
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 84.7 bits (208), Expect = 1e-16
Identities = 80/285 (28%), Positives = 133/285 (46%), Gaps = 30/285 (10%)
Query: 13 AAKLVKRNFLEALKSNDFGKLKAILIQ-RQIDVDTVFEVEDENMVLASYKQGYWLPSYKL 71
A ++ R+ EA D ++ +L + R ++ T E E+++ + GY+ + L
Sbjct: 201 AGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE---EGESLLCLACSAGYYELAQVL 257
Query: 72 KSSWA-----------TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMAN 119
+ A T L + G+++ + +LL H+A +N + G T L AC
Sbjct: 258 LAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 317
Query: 120 VDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPL 179
VD VK+L + GA + ++ +GHT L + + A+ L+ GA +N +N + +E+ L
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN-EFKESAL 376
Query: 180 HTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLL 239
A + G ++V F +E GA + M T L A H V R+LL
Sbjct: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM-----------DGHVEVARLLL 425
Query: 240 DYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDIN 284
D A+VN D F+SPL AA L +++E G ANL ++N
Sbjct: 426 DSGAQVNMPADSFESPLTLAACGGHVELAALLIERG--ANLEEVN 468
Score = 72.4 bits (176), Expect = 7e-13
Identities = 65/205 (31%), Positives = 96/205 (46%), Gaps = 20/205 (9%)
Query: 86 GHVECLLVLLDHNATINCRPNG--KTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTA 143
GHVE VLLDH A IN N ++ L +AC ++D V+ L + GA + HTA
Sbjct: 349 GHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTA 408
Query: 144 LHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDS 203
L + A+ L+ GA VNM ++ E+PL AA G EL A +E GA ++
Sbjct: 409 LMEACMDGHVEVARLLLDSGAQVNMPADSF--ESPLTLAACGGHVELAALLIERGANLEE 466
Query: 204 VNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDF-KSPLHKAAWN 262
VN TPL AA H + +LL A +NA+ ++ ++ L A
Sbjct: 467 VNDEGYTPLMEAA-----------REGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
Query: 263 CDHVLMHMMLEAGAEANLMDINGCA 287
+ +++AGA+ L GC+
Sbjct: 516 GFSEVADFLIKAGADIEL----GCS 536
Score = 62.0 bits (149), Expect = 1e-09
Identities = 58/212 (27%), Positives = 97/212 (45%), Gaps = 19/212 (8%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPNGK---TPLHVACEMANVDCVKILCDRGAKL 133
T L L+ G+V + +LL+ A IN R K +PL +A +V VK+L D G+ +
Sbjct: 1157 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDI 1216
Query: 134 NCY-SLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
N + +TAL L+ R ANV + TPL AA G +E+
Sbjct: 1217 NAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTG--LTPLMEAASGGYAEVGR 1274
Query: 193 FYVEHGAIVDS--VNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDD 250
++ GA V++ V + +T L IAA H+ C +L+ A ++ R+
Sbjct: 1275 VLLDKGADVNAPPVPSSRDTALTIAA-----------DKGHYKFCELLIHRGAHIDVRNK 1323
Query: 251 DFKSPLHKAAWNCDHVLMHMMLEAGAEANLMD 282
+PL A+ ++ ++++AGA+ + D
Sbjct: 1324 KGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
Score = 61.2 bits (147), Expect = 2e-09
Identities = 59/205 (28%), Positives = 90/205 (43%), Gaps = 12/205 (5%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPNGK--TPLHVACEMANVDCVKILCDRGAKLN 134
T L L+ GHV + +LLD I + TPL +AC + V +L RGA
Sbjct: 1090 TPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKE 1149
Query: 135 CYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFY 194
++S +T L + + K L+ GA +N +T ++ +PL AA G V
Sbjct: 1150 HRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLL 1209
Query: 195 VEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKS 254
++ G+ +NA +ET A A E V +LLD KA V R +
Sbjct: 1210 LDMGS---DINAQIETNRNTALTLACFQGRAE-------VVSLLLDRKANVEHRAKTGLT 1259
Query: 255 PLHKAAWNCDHVLMHMMLEAGAEAN 279
PL +AA + ++L+ GA+ N
Sbjct: 1260 PLMEAASGGYAEVGRVLLDKGADVN 1284
Score = 59.7 bits (143), Expect = 5e-09
Identities = 51/183 (27%), Positives = 82/183 (44%), Gaps = 13/183 (7%)
Query: 79 LHLSVLFGHVECLLVLLDHNATINCR--PNGKTPLHVACEMANVDCVKILCDRGAKLNCY 136
L L+ + GHV + +LLD + IN + N T L +AC + V +L DR A +
Sbjct: 1194 LMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHR 1253
Query: 137 SLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVE 196
+ +G T L + + L+ +GA+VN +T L AA G + +
Sbjct: 1254 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIH 1313
Query: 197 HGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPL 256
GA +D N TPL +A+ + H V ++L+ A+V+A D+ +PL
Sbjct: 1314 RGAHIDVRNKKGNTPLWLAS-----------NGGHFDVVQLLVQAGADVDAADNRKITPL 1362
Query: 257 HKA 259
A
Sbjct: 1363 MSA 1365
Score = 54.3 bits (129), Expect = 2e-07
Identities = 47/176 (26%), Positives = 81/176 (46%), Gaps = 14/176 (7%)
Query: 106 NGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGAN 165
N T L +AC + + V +L R AK+ G T L T + + L+ +G +
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113
Query: 166 VNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQ 225
+ + + + ++TPL A G E+V + GA + N TPL++AA
Sbjct: 1114 IEAQ-SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAA--------- 1163
Query: 226 EYSTEHHLVCRMLLDYKAEVNARDDDFK--SPLHKAAWNCDHVLMHMMLEAGAEAN 279
S + + ++LL+ AE+N+R SPL AA N + ++L+ G++ N
Sbjct: 1164 --SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN 1217
Score = 50.8 bits (120), Expect = 2e-06
Identities = 37/115 (32%), Positives = 50/115 (43%), Gaps = 2/115 (1%)
Query: 86 GHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTAL 144
GH+E + LL A ++ G T L ACE + D +L GA L S G T L
Sbjct: 546 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 605
Query: 145 HFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGA 199
+ + L+ +GANVN T N D T + A G +V + HGA
Sbjct: 606 MKAARAGHLCTVQFLISKGANVNRATANND-HTVVSLACAGGHLAVVELLLAHGA 659
Score = 42.4 bits (98), Expect = 8e-04
Identities = 74/311 (23%), Positives = 122/311 (39%), Gaps = 51/311 (16%)
Query: 32 KLKAILIQRQIDVDTVFEVEDEN--------------MVLASYKQGYWLPSYKLKSSWAT 77
+L A+LI+R +++ EV DE MV QG + + + + + T
Sbjct: 452 ELAALLIERGANLE---EVNDEGYTPLMEAAREGHEEMVALLLAQGANINA-QTEETQET 507
Query: 78 GLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYS 137
L L+ G E L+ A I TPL A + +++ VK L GA ++ +
Sbjct: 508 ALTLACCGGFSEVADFLIKAGADIEL--GCSTPLMEASQEGHLELVKYLLASGANVHATT 565
Query: 138 LSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEH 197
+G TAL + A L+ GA +++ ++ TPL AA G V F +
Sbjct: 566 ATGDTALTYACENGHTDVADVLLQAGA--DLEHESEGGRTPLMKAARAGHLCTVQFLISK 623
Query: 198 GAIVDSVNAHME-TPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPL 256
GA V+ A+ + T +++A + H V +LL + A+ R D + L
Sbjct: 624 GANVNRATANNDHTVVSLAC-----------AGGHLAVVELLLAHGADPTHRLKDGSTML 672
Query: 257 HKAAWNCDHVLMHMMLEAGAEAN----LMDINGCAAIQYVLKVTSVRPAAQPEICYQLLL 312
+AA G N L+D V+ + P +Q + +
Sbjct: 673 IEAA-------------KGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVP 719
Query: 313 NHGAARIYPPQ 323
H A + PPQ
Sbjct: 720 THTLAMVVPPQ 730
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 84.7 bits (208), Expect = 1e-16
Identities = 80/285 (28%), Positives = 133/285 (46%), Gaps = 30/285 (10%)
Query: 13 AAKLVKRNFLEALKSNDFGKLKAILIQ-RQIDVDTVFEVEDENMVLASYKQGYWLPSYKL 71
A ++ R+ EA D ++ +L + R ++ T E E+++ + GY+ + L
Sbjct: 201 AGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE---EGESLLCLACSAGYYELAQVL 257
Query: 72 KSSWA-----------TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMAN 119
+ A T L + G+++ + +LL H+A +N + G T L AC
Sbjct: 258 LAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 317
Query: 120 VDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPL 179
VD VK+L + GA + ++ +GHT L + + A+ L+ GA +N +N + +E+ L
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN-EFKESAL 376
Query: 180 HTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLL 239
A + G ++V F +E GA + M T L A H V R+LL
Sbjct: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM-----------DGHVEVARLLL 425
Query: 240 DYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDIN 284
D A+VN D F+SPL AA L +++E G ANL ++N
Sbjct: 426 DSGAQVNMPADSFESPLTLAACGGHVELAALLIERG--ANLEEVN 468
Score = 72.4 bits (176), Expect = 7e-13
Identities = 65/205 (31%), Positives = 96/205 (46%), Gaps = 20/205 (9%)
Query: 86 GHVECLLVLLDHNATINCRPNG--KTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTA 143
GHVE VLLDH A IN N ++ L +AC ++D V+ L + GA + HTA
Sbjct: 349 GHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTA 408
Query: 144 LHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDS 203
L + A+ L+ GA VNM ++ E+PL AA G EL A +E GA ++
Sbjct: 409 LMEACMDGHVEVARLLLDSGAQVNMPADSF--ESPLTLAACGGHVELAALLIERGANLEE 466
Query: 204 VNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDF-KSPLHKAAWN 262
VN TPL AA H + +LL A +NA+ ++ ++ L A
Sbjct: 467 VNDEGYTPLMEAA-----------REGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
Query: 263 CDHVLMHMMLEAGAEANLMDINGCA 287
+ +++AGA+ L GC+
Sbjct: 516 GFSEVADFLIKAGADIEL----GCS 536
Score = 62.0 bits (149), Expect = 1e-09
Identities = 58/212 (27%), Positives = 97/212 (45%), Gaps = 19/212 (8%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPNGK---TPLHVACEMANVDCVKILCDRGAKL 133
T L L+ G+V + +LL+ A IN R K +PL +A +V VK+L D G+ +
Sbjct: 1157 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDI 1216
Query: 134 NCY-SLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVA 192
N + +TAL L+ R ANV + TPL AA G +E+
Sbjct: 1217 NAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTG--LTPLMEAASGGYAEVGR 1274
Query: 193 FYVEHGAIVDS--VNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDD 250
++ GA V++ V + +T L IAA H+ C +L+ A ++ R+
Sbjct: 1275 VLLDKGADVNAPPVPSSRDTALTIAA-----------DKGHYKFCELLIHRGAHIDVRNK 1323
Query: 251 DFKSPLHKAAWNCDHVLMHMMLEAGAEANLMD 282
+PL A+ ++ ++++AGA+ + D
Sbjct: 1324 KGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
Score = 61.2 bits (147), Expect = 2e-09
Identities = 59/205 (28%), Positives = 90/205 (43%), Gaps = 12/205 (5%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPNGK--TPLHVACEMANVDCVKILCDRGAKLN 134
T L L+ GHV + +LLD I + TPL +AC + V +L RGA
Sbjct: 1090 TPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKE 1149
Query: 135 CYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFY 194
++S +T L + + K L+ GA +N +T ++ +PL AA G V
Sbjct: 1150 HRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLL 1209
Query: 195 VEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKS 254
++ G+ +NA +ET A A E V +LLD KA V R +
Sbjct: 1210 LDMGS---DINAQIETNRNTALTLACFQGRAE-------VVSLLLDRKANVEHRAKTGLT 1259
Query: 255 PLHKAAWNCDHVLMHMMLEAGAEAN 279
PL +AA + ++L+ GA+ N
Sbjct: 1260 PLMEAASGGYAEVGRVLLDKGADVN 1284
Score = 59.7 bits (143), Expect = 5e-09
Identities = 51/183 (27%), Positives = 82/183 (44%), Gaps = 13/183 (7%)
Query: 79 LHLSVLFGHVECLLVLLDHNATINCR--PNGKTPLHVACEMANVDCVKILCDRGAKLNCY 136
L L+ + GHV + +LLD + IN + N T L +AC + V +L DR A +
Sbjct: 1194 LMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHR 1253
Query: 137 SLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVE 196
+ +G T L + + L+ +GA+VN +T L AA G + +
Sbjct: 1254 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIH 1313
Query: 197 HGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPL 256
GA +D N TPL +A+ + H V ++L+ A+V+A D+ +PL
Sbjct: 1314 RGAHIDVRNKKGNTPLWLAS-----------NGGHFDVVQLLVQAGADVDAADNRKITPL 1362
Query: 257 HKA 259
A
Sbjct: 1363 MSA 1365
Score = 54.3 bits (129), Expect = 2e-07
Identities = 47/176 (26%), Positives = 81/176 (46%), Gaps = 14/176 (7%)
Query: 106 NGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGAN 165
N T L +AC + + V +L R AK+ G T L T + + L+ +G +
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113
Query: 166 VNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQ 225
+ + + + ++TPL A G E+V + GA + N TPL++AA
Sbjct: 1114 IEAQ-SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAA--------- 1163
Query: 226 EYSTEHHLVCRMLLDYKAEVNARDDDFK--SPLHKAAWNCDHVLMHMMLEAGAEAN 279
S + + ++LL+ AE+N+R SPL AA N + ++L+ G++ N
Sbjct: 1164 --SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN 1217
Score = 50.8 bits (120), Expect = 2e-06
Identities = 37/115 (32%), Positives = 50/115 (43%), Gaps = 2/115 (1%)
Query: 86 GHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTAL 144
GH+E + LL A ++ G T L ACE + D +L GA L S G T L
Sbjct: 546 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 605
Query: 145 HFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGA 199
+ + L+ +GANVN T N D T + A G +V + HGA
Sbjct: 606 MKAARAGHLCTVQFLISKGANVNRATANND-HTVVSLACAGGHLAVVELLLAHGA 659
Score = 42.4 bits (98), Expect = 8e-04
Identities = 74/311 (23%), Positives = 122/311 (39%), Gaps = 51/311 (16%)
Query: 32 KLKAILIQRQIDVDTVFEVEDEN--------------MVLASYKQGYWLPSYKLKSSWAT 77
+L A+LI+R +++ EV DE MV QG + + + + + T
Sbjct: 452 ELAALLIERGANLE---EVNDEGYTPLMEAAREGHEEMVALLLAQGANINA-QTEETQET 507
Query: 78 GLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYS 137
L L+ G E L+ A I TPL A + +++ VK L GA ++ +
Sbjct: 508 ALTLACCGGFSEVADFLIKAGADIEL--GCSTPLMEASQEGHLELVKYLLASGANVHATT 565
Query: 138 LSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEH 197
+G TAL + A L+ GA +++ ++ TPL AA G V F +
Sbjct: 566 ATGDTALTYACENGHTDVADVLLQAGA--DLEHESEGGRTPLMKAARAGHLCTVQFLISK 623
Query: 198 GAIVDSVNAHME-TPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPL 256
GA V+ A+ + T +++A + H V +LL + A+ R D + L
Sbjct: 624 GANVNRATANNDHTVVSLAC-----------AGGHLAVVELLLAHGADPTHRLKDGSTML 672
Query: 257 HKAAWNCDHVLMHMMLEAGAEAN----LMDINGCAAIQYVLKVTSVRPAAQPEICYQLLL 312
+AA G N L+D V+ + P +Q + +
Sbjct: 673 IEAA-------------KGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVP 719
Query: 313 NHGAARIYPPQ 323
H A + PPQ
Sbjct: 720 THTLAMVVPPQ 730
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 83.6 bits (205), Expect = 3e-16
Identities = 63/202 (31%), Positives = 96/202 (47%), Gaps = 14/202 (6%)
Query: 89 ECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFC 147
+ + LLD+ A++N C NG+T L A ++D V +L RGA L GHT L
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585
Query: 148 TTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAH 207
L+ GAN+N +QD T L +AA G +E+V+ + G VD +A
Sbjct: 586 ARQGHTKVVNCLIGCGANIN--HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADAD 643
Query: 208 METPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVL 267
T L AA+ H + LL + AEVN D++ ++ L AA+ +
Sbjct: 644 SRTALRAAAWGG-----------HEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREI 692
Query: 268 MHMMLEAGAEANLMDINGCAAI 289
+ +L+ GAE N D++G A+
Sbjct: 693 VEHLLDHGAEVNHEDVDGRTAL 714
Score = 79.3 bits (194), Expect = 6e-15
Identities = 68/222 (30%), Positives = 102/222 (45%), Gaps = 19/222 (8%)
Query: 70 KLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVA-----CEMANVDCV 123
K + T L + GH E + LLDH A +N +G+T L VA + V
Sbjct: 672 KADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVV 731
Query: 124 KILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAA 183
+L DRGA+++ G T L + L+ GA+V+ NN TPL AA
Sbjct: 732 SLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNN--GRTPLLAAA 789
Query: 184 HFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKA 243
G + +V + GA VDS+++ T L+IA+ + + V R LLD
Sbjct: 790 SMGHASVVNTLLFWGAAVDSIDSEGRTVLSIAS-----------AQGNVEVVRTLLDRGL 838
Query: 244 EVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDING 285
+ N RDD +PLH AA+ ++ ++E GA N +D +G
Sbjct: 839 DENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
Score = 72.8 bits (177), Expect = 6e-13
Identities = 62/249 (24%), Positives = 109/249 (43%), Gaps = 21/249 (8%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ GH L++ A N N G+ P +A + + DCV+IL + + ++
Sbjct: 849 TPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQ 908
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
G AL + L GA+VN K + D L+ A + +++
Sbjct: 909 RGYDGRNALRVAALEGHRDIVELLFSHGADVNCK--DADGRPTLYILALENQLTMAEYFL 966
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
E+GA V++ +A T L ++ + H + ++L+ Y A+VNA D++ +S
Sbjct: 967 ENGANVEASDAEGRTALHVSCWQG-----------HMEMVQVLIAYHADVNAADNEKRSA 1015
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHG 315
L AAW ++ +++E GA + G A+ + + Q+LL HG
Sbjct: 1016 LQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHID-------VVQVLLEHG 1068
Query: 316 AARIYPPQF 324
A + QF
Sbjct: 1069 ADPNHADQF 1077
Score = 71.2 bits (173), Expect = 2e-12
Identities = 63/210 (30%), Positives = 93/210 (44%), Gaps = 9/210 (4%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATIN-CRPNGKTPLHVACEMANVDCVKILCDRGAKLNC 135
T L L+ GH + + L+ A IN +G T L A + + V L G K++C
Sbjct: 580 TPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDC 639
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
TAL L+ GA VN N + T L AA+ G E+V +
Sbjct: 640 ADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADN--EGRTALIAAAYMGHREIVEHLL 697
Query: 196 EHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSP 255
+HGA V+ + T L++AA S H V +L+D AEV+ D D +P
Sbjct: 698 DHGAEVNHEDVDGRTALSVAALCV------PASKGHASVVSLLIDRGAEVDHCDKDGMTP 751
Query: 256 LHKAAWNCDHVLMHMMLEAGAEANLMDING 285
L AA+ ++ ++LE GA+ + D NG
Sbjct: 752 LLVAAYEGHVDVVDLLLEGGADVDHTDNNG 781
Score = 68.2 bits (165), Expect = 1e-11
Identities = 56/213 (26%), Positives = 97/213 (45%), Gaps = 20/213 (9%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAKLNC 135
T L ++ GHV+ + +LL+ A ++ N G+TPL A M + V L GA ++
Sbjct: 750 TPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDS 809
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEE--TPLHTAAHFGLSELVAF 193
G T L + ++ + L+ RG + N++D+ TPLH AA G +
Sbjct: 810 IDSEGRTVLSIASAQGNVEVVRTLLDRG----LDENHRDDAGWTPLHMAAFEGHRLICEA 865
Query: 194 YVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVC-RMLLDYKAEVNARDDDF 252
+E GA + ++ P +A S E H C ++LL+ K+ ++ R D
Sbjct: 866 LIEQGARTNEIDNDGRIPFILA------------SQEGHYDCVQILLENKSNIDQRGYDG 913
Query: 253 KSPLHKAAWNCDHVLMHMMLEAGAEANLMDING 285
++ L AA ++ ++ GA+ N D +G
Sbjct: 914 RNALRVAALEGHRDIVELLFSHGADVNCKDADG 946
Score = 67.0 bits (162), Expect = 3e-11
Identities = 53/210 (25%), Positives = 99/210 (47%), Gaps = 14/210 (6%)
Query: 86 GHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTAL 144
GH +C+ +LL++ + I+ R +G+ L VA + D V++L GA +NC G L
Sbjct: 891 GHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTL 950
Query: 145 HFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSV 204
+ + + A+ + GANV + ++ + T LH + G E+V + + A V++
Sbjct: 951 YILALENQLTMAEYFLENGANV--EASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAA 1008
Query: 205 NAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCD 264
+ + L AA+ H V ++L+++ A V+ + + L AA
Sbjct: 1009 DNEKRSALQSAAWQG-----------HVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGH 1057
Query: 265 HVLMHMMLEAGAEANLMDINGCAAIQYVLK 294
++ ++LE GA+ N D G A++ K
Sbjct: 1058 IDVVQVLLEHGADPNHADQFGRTAMRVAAK 1087
Score = 47.4 bits (111), Expect = 3e-05
Identities = 38/134 (28%), Positives = 60/134 (44%), Gaps = 13/134 (9%)
Query: 157 KQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAA 216
+ L+ GA+VN +N T L AA+ G ++V V GA ++ +AH TPL +AA
Sbjct: 529 RTLLDNGASVNQCDSNG--RTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAA 586
Query: 217 YWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGA 276
H V L+ A +N D D + L AAW ++ +L AG
Sbjct: 587 RQG-----------HTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGV 635
Query: 277 EANLMDINGCAAIQ 290
+ + D + A++
Sbjct: 636 KVDCADADSRTALR 649
Score = 40.8 bits (94), Expect = 0.002
Identities = 30/106 (28%), Positives = 49/106 (46%), Gaps = 5/106 (4%)
Query: 86 GHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTAL 144
GHV+ + +L++H A ++ N G T L +A + ++D V++L + GA N G TA+
Sbjct: 1023 GHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAM 1082
Query: 145 HFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSEL 190
K L GA+ + N +P+HT L L
Sbjct: 1083 RVAAKNGHSQIIKLLEKYGAS----SLNGCSPSPVHTMEQKPLQSL 1124
Score = 32.3 bits (72), Expect = 0.84
Identities = 19/57 (33%), Positives = 31/57 (54%), Gaps = 1/57 (1%)
Query: 76 ATGLHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGA 131
AT L ++ GH++ + VLL+H A N G+T + VA + + +K+L GA
Sbjct: 1046 ATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
>gi|13129098 ankyrin repeat and SOCS box-containing 8 [Homo sapiens]
Length = 288
Score = 80.1 bits (196), Expect = 4e-15
Identities = 64/220 (29%), Positives = 106/220 (48%), Gaps = 22/220 (10%)
Query: 94 LLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSI 153
L+ A +NC PLH AC +++ DCV++L ++GA++N TALH+
Sbjct: 40 LIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE- 98
Query: 154 LCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLA 213
C + L+ GAN N N+D TPLH AA +E V +E GA V++++ + +TPL+
Sbjct: 99 ACVEVLLEYGANPNALDGNRD--TPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLS 156
Query: 214 IAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLE 273
A A++ + S +LLDY AEV + ++P+ + L+ L
Sbjct: 157 WA---AMKGNLESVS--------ILLDYGAEVRVINLIGQTPISRLV-----ALLVRGLG 200
Query: 274 AGAEANLMDINGCAAIQYVLKVTSVRP---AAQPEICYQL 310
E + ++ A + L+ P A P++C +L
Sbjct: 201 TEKEDSCFELLHRAVGHFELRKNGTMPREVARDPQLCEKL 240
Score = 68.6 bits (166), Expect = 1e-11
Identities = 76/280 (27%), Positives = 120/280 (42%), Gaps = 48/280 (17%)
Query: 157 KQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAA 216
+ L+ GA+VN PLH A ++ V +E GA V++++ + T L
Sbjct: 38 EDLIRGGADVNCTHGTLK---PLHCACMVSDADCVELLLEKGAEVNALDGYNRTAL---- 90
Query: 217 YWALRFKEQEYSTEHHLVC-RMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAG 275
Y+ E C +LL+Y A NA D + +PLH AA+ + + +LE+G
Sbjct: 91 ---------HYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESG 141
Query: 276 AEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAA-----RIYPPQFHKVIQA 330
A N +D N + + ++ + +LL++GA I +++
Sbjct: 142 ASVNALDYNNDTPLSWAAMKGNLESVS-------ILLDYGAEVRVINLIGQTPISRLVAL 194
Query: 331 C---------HSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDL-EKYWDFYHSLFTVCCNS 380
SC + + V +E + T R D L EK TV C++
Sbjct: 195 LVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREVARDPQLCEK--------LTVLCSA 246
Query: 381 PRTLMHLSRCAIRRTLH-NRCHRAIPLLSLPLSLKKYLLL 419
P TL L+R A+RR+L A+ L LP SLK+YLLL
Sbjct: 247 PGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLL 286
Score = 64.7 bits (156), Expect = 2e-10
Identities = 43/136 (31%), Positives = 69/136 (50%), Gaps = 4/136 (2%)
Query: 79 LHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAKLNCYS 137
LH + + +C+ +LL+ A +N +T LH A E CV++L + GA N
Sbjct: 57 LHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALD 115
Query: 138 LSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEH 197
+ T LH+ ++ C + L+ GA+VN N D TPL AA G E V+ +++
Sbjct: 116 GNRDTPLHWAAFKNNAECVRALLESGASVNALDYNND--TPLSWAAMKGNLESVSILLDY 173
Query: 198 GAIVDSVNAHMETPLA 213
GA V +N +TP++
Sbjct: 174 GAEVRVINLIGQTPIS 189
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 79.0 bits (193), Expect = 8e-15
Identities = 62/234 (26%), Positives = 103/234 (44%), Gaps = 29/234 (12%)
Query: 77 TGLHLSVLFGHVECLLVLLDHNATINCRPNGK-TPLHVACEMANVDCVKILCDRGAKLNC 135
T LH++ + GH+E VLL H A +N + TPLH+A + ++L GA +N
Sbjct: 136 TALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNV 195
Query: 136 YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV 195
G LH + + AK L+ G+ ++ + ++ PLH + FG ++V + +
Sbjct: 196 SGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLL 255
Query: 196 EHGAIVDS--VNAHMETPLAIAAY---------------WALRFKEQEYS-TEHHLVC-- 235
+ V VN + +TPL +A Y KE +S T H C
Sbjct: 256 QSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTY 315
Query: 236 -------RMLLDYKA-EVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLM 281
+ LLD +N + D + LH A ++ L+ +L+ GA+ NL+
Sbjct: 316 GKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLV 369
Score = 65.9 bits (159), Expect = 7e-11
Identities = 54/183 (29%), Positives = 87/183 (47%), Gaps = 19/183 (10%)
Query: 106 NGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGAN 165
NG T LH+A N + + L GA + G TALH T + A L+ GAN
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 159
Query: 166 VNMKTNNQDEE--TPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFK 223
VN+ QD TPLH AA++G ++ ++ GA V+ + PL +A+ A F
Sbjct: 160 VNI----QDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLAS--AKGFL 213
Query: 224 EQEYSTEHHLVCRMLLD--YKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLM 281
+ ++L++ KA+VNA+D++ PLH + H ++ +L++ E
Sbjct: 214 N---------IAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPH 264
Query: 282 DIN 284
+N
Sbjct: 265 VVN 267
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.135 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,927,587
Number of Sequences: 37866
Number of extensions: 752379
Number of successful extensions: 5754
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 277
Number of HSP's successfully gapped in prelim test: 63
Number of HSP's that attempted gapping in prelim test: 2063
Number of HSP's gapped (non-prelim): 1561
length of query: 426
length of database: 18,247,518
effective HSP length: 105
effective length of query: 321
effective length of database: 14,271,588
effective search space: 4581179748
effective search space used: 4581179748
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.