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Search of human proteins with 7669518
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]
(296 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens] 603 e-173
gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens] 160 1e-39
gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens] 160 1e-39
gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens] 160 1e-39
gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens] 139 3e-33
gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens] 139 3e-33
gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens] 139 3e-33
gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens] 139 3e-33
gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens] 139 3e-33
gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens] 139 3e-33
gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens] 138 7e-33
gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens] 109 3e-24
gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens] 109 3e-24
gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens] 108 7e-24
gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens] 96 3e-20
gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens] 96 3e-20
gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens] 95 6e-20
gi|66730481 neuregulin 3 [Homo sapiens] 78 8e-15
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens] 61 1e-09
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens] 61 1e-09
gi|7669530 neuregulin 2 isoform 3 [Homo sapiens] 53 4e-07
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens] 53 4e-07
gi|91982772 mucin 17 [Homo sapiens] 46 4e-05
gi|20070380 neuregulin 4 [Homo sapiens] 46 4e-05
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 41 0.001
gi|24041035 notch 2 preproprotein [Homo sapiens] 39 0.005
gi|93102379 low density lipoprotein-related protein 1B precursor... 39 0.007
gi|88702793 slit-like 2 [Homo sapiens] 38 0.009
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 38 0.012
gi|4502199 amphiregulin preproprotein [Homo sapiens] 37 0.016
>gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]
Length = 296
Score = 603 bits (1555), Expect = e-173
Identities = 296/296 (100%), Positives = 296/296 (100%)
Query: 1 MEIYSPDMSEVAAERSSSPSTQLSADPSLDGLPAAEDMPEPQTEDGRTPGLVGLAVPCCA 60
MEIYSPDMSEVAAERSSSPSTQLSADPSLDGLPAAEDMPEPQTEDGRTPGLVGLAVPCCA
Sbjct: 1 MEIYSPDMSEVAAERSSSPSTQLSADPSLDGLPAAEDMPEPQTEDGRTPGLVGLAVPCCA 60
Query: 61 CLEAERLRGCLNSEKICIVPILACLVSLCLCIAGLKWVFVDKIFEYDSPTHLDPGGLGQD 120
CLEAERLRGCLNSEKICIVPILACLVSLCLCIAGLKWVFVDKIFEYDSPTHLDPGGLGQD
Sbjct: 61 CLEAERLRGCLNSEKICIVPILACLVSLCLCIAGLKWVFVDKIFEYDSPTHLDPGGLGQD 120
Query: 121 PIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPTPKNRIFA 180
PIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPTPKNRIFA
Sbjct: 121 PIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPTPKNRIFA 180
Query: 181 FSFLPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAPKLSTSTSTTGTSHLVKCAEK 240
FSFLPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAPKLSTSTSTTGTSHLVKCAEK
Sbjct: 181 FSFLPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAPKLSTSTSTTGTSHLVKCAEK 240
Query: 241 EKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSLPE 296
EKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSLPE
Sbjct: 241 EKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSLPE 296
>gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens]
Length = 207
Score = 160 bits (405), Expect = 1e-39
Identities = 74/86 (86%), Positives = 77/86 (89%)
Query: 211 TTETNLQTAPKLSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE 270
+ N+ +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE
Sbjct: 122 SASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE 181
Query: 271 FTGDRCQNYVMASFYSTSTPFLSLPE 296
FTGDRCQNYVMASFYSTSTPFLSLPE
Sbjct: 182 FTGDRCQNYVMASFYSTSTPFLSLPE 207
>gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens]
Length = 241
Score = 160 bits (405), Expect = 1e-39
Identities = 74/74 (100%), Positives = 74/74 (100%)
Query: 223 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 282
STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA
Sbjct: 168 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 227
Query: 283 SFYSTSTPFLSLPE 296
SFYSTSTPFLSLPE
Sbjct: 228 SFYSTSTPFLSLPE 241
>gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]
Length = 422
Score = 160 bits (405), Expect = 1e-39
Identities = 74/86 (86%), Positives = 77/86 (89%)
Query: 211 TTETNLQTAPKLSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE 270
+ N+ +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE
Sbjct: 337 SASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE 396
Query: 271 FTGDRCQNYVMASFYSTSTPFLSLPE 296
FTGDRCQNYVMASFYSTSTPFLSLPE
Sbjct: 397 FTGDRCQNYVMASFYSTSTPFLSLPE 422
>gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]
Length = 459
Score = 139 bits (350), Expect = 3e-33
Identities = 63/63 (100%), Positives = 63/63 (100%)
Query: 223 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 282
STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA
Sbjct: 168 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 227
Query: 283 SFY 285
SFY
Sbjct: 228 SFY 230
>gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]
Length = 420
Score = 139 bits (350), Expect = 3e-33
Identities = 63/63 (100%), Positives = 63/63 (100%)
Query: 223 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 282
STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA
Sbjct: 168 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 227
Query: 283 SFY 285
SFY
Sbjct: 228 SFY 230
>gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]
Length = 590
Score = 139 bits (350), Expect = 3e-33
Identities = 63/75 (84%), Positives = 66/75 (88%)
Query: 211 TTETNLQTAPKLSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE 270
+ N+ +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE
Sbjct: 101 SASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNE 160
Query: 271 FTGDRCQNYVMASFY 285
FTGDRCQNYVMASFY
Sbjct: 161 FTGDRCQNYVMASFY 175
>gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]
Length = 624
Score = 139 bits (350), Expect = 3e-33
Identities = 63/63 (100%), Positives = 63/63 (100%)
Query: 223 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 282
STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA
Sbjct: 147 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 206
Query: 283 SFY 285
SFY
Sbjct: 207 SFY 209
>gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]
Length = 637
Score = 139 bits (350), Expect = 3e-33
Identities = 63/63 (100%), Positives = 63/63 (100%)
Query: 223 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 282
STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA
Sbjct: 168 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 227
Query: 283 SFY 285
SFY
Sbjct: 228 SFY 230
>gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
Length = 645
Score = 139 bits (350), Expect = 3e-33
Identities = 63/63 (100%), Positives = 63/63 (100%)
Query: 223 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 282
STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA
Sbjct: 168 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 227
Query: 283 SFY 285
SFY
Sbjct: 228 SFY 230
>gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]
Length = 607
Score = 138 bits (347), Expect = 7e-33
Identities = 62/63 (98%), Positives = 63/63 (100%)
Query: 223 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 282
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA
Sbjct: 130 ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 189
Query: 283 SFY 285
SFY
Sbjct: 190 SFY 192
>gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]
Length = 640
Score = 109 bits (272), Expect = 3e-24
Identities = 51/58 (87%), Positives = 51/58 (87%)
Query: 223 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 280
STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG RC V
Sbjct: 168 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 225
>gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]
Length = 462
Score = 109 bits (272), Expect = 3e-24
Identities = 51/58 (87%), Positives = 51/58 (87%)
Query: 223 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 280
STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG RC V
Sbjct: 168 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 225
>gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]
Length = 308
Score = 108 bits (269), Expect = 7e-24
Identities = 50/58 (86%), Positives = 51/58 (87%)
Query: 223 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 280
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG RC V
Sbjct: 14 ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
>gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens]
Length = 177
Score = 96.3 bits (238), Expect = 3e-20
Identities = 44/56 (78%), Positives = 47/56 (83%)
Query: 211 TTETNLQTAPKLSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 266
+ N+ +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 122 SASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 177
>gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens]
Length = 211
Score = 96.3 bits (238), Expect = 3e-20
Identities = 44/44 (100%), Positives = 44/44 (100%)
Query: 223 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 266
STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 168 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 211
>gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens]
Length = 194
Score = 95.1 bits (235), Expect = 6e-20
Identities = 43/44 (97%), Positives = 44/44 (100%)
Query: 223 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 266
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 151 ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 194
>gi|66730481 neuregulin 3 [Homo sapiens]
Length = 696
Score = 78.2 bits (191), Expect = 8e-15
Identities = 82/341 (24%), Positives = 128/341 (37%), Gaps = 77/341 (22%)
Query: 8 MSEVAAERSSSPSTQLSADPSLDGLPAAEDMPEPQTEDGRTPGLVGLAVP-----CCACL 62
MSE AA S + +A + +G AA G G G A P C C+
Sbjct: 1 MSEGAAAASPPGAASAAAASAEEGTAAAA--AAAAAGGGPDGGGEGAAEPPRELRCSDCI 58
Query: 63 EAERLRGCLNSEKICIVPILACLVSLCLCIAGLKWVFVDKIFEYDSPTHLDPGGLGQDPI 122
R + L C+VP+ + L L + LKW+ V + EY +D G+GQDP
Sbjct: 59 VWNRQQTWL-----CVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDLVDSKGMGQDPF 113
Query: 123 ISLDATA---ASAVWVSSEAYTSPV---------SRAQSESEVQVTV--------QGDKA 162
++ A ++ + TSP SR + ++T G +
Sbjct: 114 FLSKPSSFPKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTTITRAPTRFPGHRV 173
Query: 163 VVSFEPSAAPTPKNRIFAFSFLPSTAPSFPSPT---RNPEVRTPKSATQPQ--------- 210
+ P + T +N + +TAP F S T R P TP + P
Sbjct: 174 PIRASPRST-TARNTAAPATVPSTTAPFFSSSTLGSRPPVPGTPSTQAMPSWPTAAYATS 232
Query: 211 ------------------------------TTETNLQTAPKLSTST-STTGTSHLVKCAE 239
TT T+PK T+T ST + H C +
Sbjct: 233 SYLHDSTPSWTLSPFQDAASSSSSSSSSATTTTPETSTSPKFHTTTYSTERSEHFKPCRD 292
Query: 240 KEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 280
K+ +C+N GECF+++ L+ ++ C+C + G RC ++
Sbjct: 293 KDLAYCLNDGECFVIETLTGSHKH-CRCKEGYQGVRCDQFL 332
>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
Length = 844
Score = 60.8 bits (146), Expect = 1e-09
Identities = 25/61 (40%), Positives = 40/61 (65%), Gaps = 3/61 (4%)
Query: 224 TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMAS 283
++T ++ + H KC E K++CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +
Sbjct: 332 STTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVN 388
Query: 284 F 284
F
Sbjct: 389 F 389
>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
Length = 852
Score = 60.8 bits (146), Expect = 1e-09
Identities = 25/61 (40%), Positives = 40/61 (65%), Gaps = 3/61 (4%)
Query: 224 TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMAS 283
++T ++ + H KC E K++CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +
Sbjct: 332 STTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVN 388
Query: 284 F 284
F
Sbjct: 389 F 389
>gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]
Length = 858
Score = 52.8 bits (125), Expect = 4e-07
Identities = 22/53 (41%), Positives = 34/53 (64%), Gaps = 3/53 (5%)
Query: 224 TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRC 276
++T ++ + H KC E K++CVNGG C+ ++ ++ S CKCPN F G RC
Sbjct: 332 STTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPNGFFGQRC 381
>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
Length = 850
Score = 52.8 bits (125), Expect = 4e-07
Identities = 22/53 (41%), Positives = 34/53 (64%), Gaps = 3/53 (5%)
Query: 224 TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRC 276
++T ++ + H KC E K++CVNGG C+ ++ ++ S CKCPN F G RC
Sbjct: 332 STTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPNGFFGQRC 381
>gi|91982772 mucin 17 [Homo sapiens]
Length = 4493
Score = 45.8 bits (107), Expect = 4e-05
Identities = 44/158 (27%), Positives = 66/158 (41%), Gaps = 18/158 (11%)
Query: 128 TAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPTPKNRIFAFSFLPST 187
+A S S+ T PV+ + SES T+ +F P+ + TP P+T
Sbjct: 4029 SATSTPHTSTSVTTRPVTPS-SESSRPSTITSHTIPPTFPPAHSSTP----------PTT 4077
Query: 188 APSFPSPTRNPE-VRTPKSATQPQTTETNLQTAPKLSTSTSTTGTSHLVKCAEKEKTFCV 246
+ S S T NPE V T + T+P T T+ T + T+TT S+ +T
Sbjct: 4078 SAS--STTVNPEAVTTMTTRTKPSTRTTSFPTVTTTAVPTNTTIKSNPTSTPTVPRTTTC 4135
Query: 247 NGGEC----FMVKDLSNPSRYLCKCPNEFTGDRCQNYV 280
G C K+ C+CPN + G+ C+ V
Sbjct: 4136 FGDGCQNTASRCKNGGTWDGLKCQCPNLYYGELCEEVV 4173
Score = 34.3 bits (77), Expect = 0.13
Identities = 30/124 (24%), Positives = 52/124 (41%), Gaps = 9/124 (7%)
Query: 118 GQDPIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAA-PTPKN 176
G P+ SL + + + VSSEA T + S+++V + + + + S TP
Sbjct: 1571 GSTPLTSLPVS--TMLVVSSEANTLSTTPIDSKTQVTASTEASSSTTAEGSSMTISTPSE 1628
Query: 177 RIFAFSFLPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAP------KLSTSTSTTG 230
+ +P + SP + TP + P T T + ++P + TST T G
Sbjct: 1629 GSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPTPAEGTSMPTSTYTEG 1688
Query: 231 TSHL 234
+ L
Sbjct: 1689 RTPL 1692
Score = 33.9 bits (76), Expect = 0.18
Identities = 32/134 (23%), Positives = 58/134 (43%), Gaps = 20/134 (14%)
Query: 114 PGGLGQDPIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAP- 172
P G P+ S+ + + + VSSEA T + S+++V + + + E ++ P
Sbjct: 1154 PPSEGTTPLASMPVS--TTLVVSSEANTLSTTPVDSKTQVATSTEASSPPPTAEVTSMPT 1211
Query: 173 -TPKNRIFAFSFLP-----------STAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAP 220
TP R + +P ST + P T P + ++++ P T E
Sbjct: 1212 STPGERSTPLTSMPVRHTPVASSEASTLSTSPVDTSTPVTTSAETSSSPTTAE-----GT 1266
Query: 221 KLSTSTSTTGTSHL 234
L TST++ G++ L
Sbjct: 1267 SLPTSTTSEGSTLL 1280
Score = 33.5 bits (75), Expect = 0.23
Identities = 28/129 (21%), Positives = 52/129 (40%), Gaps = 11/129 (8%)
Query: 108 SPTHLDPGGL-------GQDPIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGD 160
SPT D + G P+ S+ + + SSEA T + + + + + +
Sbjct: 728 SPTTADGASMPTSTPSEGSTPLTSMPVS--KTLLTSSEASTLSTTPLDTSTHITTSTEAS 785
Query: 161 KAVVSFEPSAAP--TPKNRIFAFSFLPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQT 218
+ + E ++ P TP + +P + SP + TP + P TT T + +
Sbjct: 786 CSPTTTEGTSMPISTPSEGSPLLTSIPVSITPVTSPEASTLSTTPVDSNSPVTTSTEVSS 845
Query: 219 APKLSTSTS 227
+P + TS
Sbjct: 846 SPTPAEGTS 854
Score = 31.6 bits (70), Expect = 0.87
Identities = 34/144 (23%), Positives = 58/144 (40%), Gaps = 15/144 (10%)
Query: 108 SPTHLDPGGL-------GQDPIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGD 160
SPT D + G+ P+ S+ + + SSE T + A + + V Q
Sbjct: 1907 SPTTADGSSMPTSTPREGRPPLTSIPVSTTTVA--SSEINTLSTTLADTRTPVTTYSQAS 1964
Query: 161 KAVVSFEPSAAPTPKNRIFAFSFLPSTAPSFP-SPTRNPEVRTPKSATQPQTTETNLQTA 219
+ + + ++ PTP A+S + S P S T +T P T T T+
Sbjct: 1965 SSPTTADGTSMPTP-----AYSEGSTPLTSMPLSTTLVVSSEASTLSTTPVDTSTPATTS 2019
Query: 220 PKLSTSTSTTGTSHLVKCAEKEKT 243
+ S+S +T G + + E+T
Sbjct: 2020 TEGSSSPTTAGGTSIQTSTPSERT 2043
Score = 31.2 bits (69), Expect = 1.1
Identities = 23/105 (21%), Positives = 41/105 (39%), Gaps = 4/105 (3%)
Query: 118 GQDPIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPT--PK 175
G P+ S+ + V SSEA T + + + V + + + + E ++ PT P
Sbjct: 2395 GSTPLTSVPVSTMPVV--SSEASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPS 2452
Query: 176 NRIFAFSFLPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAP 220
+ +P + S TP + P TT T ++P
Sbjct: 2453 EGTTPLASMPVSTTPVVSSEAGTLSTTPVDTSTPMTTSTEASSSP 2497
Score = 30.8 bits (68), Expect = 1.5
Identities = 26/126 (20%), Positives = 52/126 (41%), Gaps = 8/126 (6%)
Query: 119 QDPIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAP------ 172
++ I S A ++A S EAYTS + + + + Q + + E + P
Sbjct: 154 EESISSTMAFVSTAPLPSFEAYTSLTYKVDMSTPLTTSTQASSSPTTPESTTIPKSTNSE 213
Query: 173 --TPKNRIFAFSFLPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAPKLSTSTSTTG 230
TP + A + +++ + T E+ TP + + ++ P LS S + G
Sbjct: 214 GSTPLTSMPASTMKVASSEAITLLTTPVEISTPVTISAQASSSPTTAEGPSLSNSAPSGG 273
Query: 231 TSHLVK 236
++ L +
Sbjct: 274 STPLTR 279
Score = 30.4 bits (67), Expect = 1.9
Identities = 27/99 (27%), Positives = 42/99 (42%), Gaps = 11/99 (11%)
Query: 121 PIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPTPKNRIFA 180
P+ S +A+ S V + PV+ + S T +G +S PS TP I
Sbjct: 2880 PVASSEASTLSTTPVDTSI---PVTTSTEGSSSPTTAEGTSMPIS-TPSEVSTPLTSILV 2935
Query: 181 FSFLP------STAPSFPSPTRNPEVRTPKSATQPQTTE 213
S +P ST + P TR P + ++++ P T E
Sbjct: 2936 -STVPVAGSEASTLSTTPVDTRTPVTTSAEASSSPTTAE 2973
Score = 30.0 bits (66), Expect = 2.5
Identities = 35/140 (25%), Positives = 50/140 (35%), Gaps = 31/140 (22%)
Query: 121 PIISLDATAASA--------VWVSSEAYTSPVSR--------AQSESEVQVT-------- 156
P++S +A SA V S+EA +SP + SE +T
Sbjct: 935 PVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPSEGTTPLTSTPVSHTL 994
Query: 157 -VQGDKAVVSFEPSAAPTPKNRIFAFSFLPSTAPSFPSPTRNPE------VRTPKSATQP 209
+ + +S P + TP S P TA PT P R P S T
Sbjct: 995 VANSEASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPVSTTMV 1054
Query: 210 QTTETNLQTAPKLSTSTSTT 229
++ET+ + TST T
Sbjct: 1055 ASSETSTLSTTPADTSTPVT 1074
Score = 30.0 bits (66), Expect = 2.5
Identities = 24/114 (21%), Positives = 45/114 (39%), Gaps = 4/114 (3%)
Query: 116 GLGQDPIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAP--T 173
G + P+ S+ + SSEA T + A + + V + + + + E + P T
Sbjct: 2983 GERRTPLTSMSVSTMPVA--SSEASTLSRTPADTSTPVTTSTEASSSPTTAEGTGIPIST 3040
Query: 174 PKNRIFAFSFLPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAPKLSTSTS 227
P + +P + P + TP + P T T + ++P + TS
Sbjct: 3041 PSEGSTPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVSSSPTPAEGTS 3094
Score = 30.0 bits (66), Expect = 2.5
Identities = 25/82 (30%), Positives = 33/82 (40%), Gaps = 7/82 (8%)
Query: 157 VQGDKAVVSFEPSAAPTPKNRIFAFSFLPSTAPSFPSPTRNPEVRTPKSATQPQTT---- 212
V + + +S P TP S P+TA PT +P T A+ P +T
Sbjct: 3353 VSSEASTLSTTPVDTSTPVTTSTEASLSPTTAEGTSIPTSSPSEGTTPLASMPVSTTPVV 3412
Query: 213 --ETN-LQTAPKLSTSTSTTGT 231
E N L T P S + TT T
Sbjct: 3413 SSEVNTLSTTPVDSNTLVTTST 3434
Score = 29.6 bits (65), Expect = 3.3
Identities = 25/107 (23%), Positives = 42/107 (39%), Gaps = 10/107 (9%)
Query: 121 PIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPTPKNRIFA 180
P+ + +A+ S V S SPV + + S +G +S TP A
Sbjct: 1466 PVANSEASTLSTTPVDSN---SPVVTSTAVSSSPTPAEGTSIAIS-------TPSEGSTA 1515
Query: 181 FSFLPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAPKLSTSTS 227
+ +P + + S N TP + P TT + ++P + TS
Sbjct: 1516 LTSIPVSTTTVASSEINSLSTTPAVTSTPVTTYSQASSSPTTADGTS 1562
Score = 29.6 bits (65), Expect = 3.3
Identities = 31/130 (23%), Positives = 49/130 (37%), Gaps = 5/130 (3%)
Query: 107 DSPTHLDPGGLGQDPIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVT----VQGDKA 162
DS P S +AT+++ +S ++P + V V+ + +
Sbjct: 3181 DSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPVASSEAS 3240
Query: 163 VVSFEPSAAPTPKNRIFAFSFLPSTAPSFPSPTRNP-EVRTPKSATQPQTTETNLQTAPK 221
++S P + TP S P TA PT P E TP ++ TT
Sbjct: 3241 ILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASSETST 3300
Query: 222 LSTSTSTTGT 231
LST+ + T T
Sbjct: 3301 LSTTPADTST 3310
Score = 29.3 bits (64), Expect = 4.3
Identities = 30/117 (25%), Positives = 46/117 (39%), Gaps = 12/117 (10%)
Query: 124 SLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPTPKNRIFAFSF 183
+L AT+A + ++ TS +E+ T ++ + P TP S
Sbjct: 875 TLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPGEGSTPLT-----SM 929
Query: 184 LPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAP------KLSTSTSTTGTSHL 234
ST P S R TP + P TT T ++P + TST + GT+ L
Sbjct: 930 PDSTTPVVSSEARTLSA-TPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPSEGTTPL 985
Score = 29.3 bits (64), Expect = 4.3
Identities = 32/140 (22%), Positives = 48/140 (34%), Gaps = 31/140 (22%)
Query: 121 PIISLDATAASA--------VWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAP 172
P+++ +A+ SA V S+EA +SP + + +G + S S
Sbjct: 2231 PVVTSEASTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGTTPLTSIPVSHTL 2290
Query: 173 TPKNRIFAFSFLP---------STAPSFPSPT--------------RNPEVRTPKSATQP 209
+ + S P ST S P PT P R P S T
Sbjct: 2291 VANSEVSTLSTTPVDSNTPFTTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMV 2350
Query: 210 QTTETNLQTAPKLSTSTSTT 229
+ ET+ + TST T
Sbjct: 2351 ASFETSTLSTTPADTSTPVT 2370
Score = 29.3 bits (64), Expect = 4.3
Identities = 25/107 (23%), Positives = 44/107 (41%), Gaps = 10/107 (9%)
Query: 121 PIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPTPKNRIFA 180
P+ S +A+ S V S +P++ + S T +G S PS TP
Sbjct: 3233 PVASSEASILSTTPVDSN---TPLTTSTEASSSPPTAEGTSMPTS-TPSEGSTP------ 3282
Query: 181 FSFLPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAPKLSTSTS 227
+ +P + + S + TP + P TT + ++P ++ TS
Sbjct: 3283 LTSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTS 3329
Score = 28.9 bits (63), Expect = 5.7
Identities = 27/112 (24%), Positives = 40/112 (35%), Gaps = 13/112 (11%)
Query: 133 VWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPTPKNRIFAFSFLP------- 185
V +SEA +SP + + +G + S S P + S P
Sbjct: 424 VTTASEASSSPTTAEDTSIATSTPSEGSTPLTSMPVSTTPVASSEASNLSTTPVDSKTQV 483
Query: 186 --STAPSFPSPT---RNPEVRTPKSATQPQTTETNLQTAPKLSTSTSTTGTS 232
ST S PT + TP + P T ++ T P S+ ST T+
Sbjct: 484 TTSTEASSSPPTAEVNSMPTSTPSEGSTP-LTSMSVSTMPVASSEASTLSTT 534
Score = 28.9 bits (63), Expect = 5.7
Identities = 28/117 (23%), Positives = 50/117 (42%), Gaps = 9/117 (7%)
Query: 118 GQDPIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPTP--K 175
G P+ ++ + + + VSSEA T+ + A S + V + + + + E ++ PT
Sbjct: 568 GSTPLTNMPVS--TRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTSTYS 625
Query: 176 NRIFAFSFLPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAPKLSTSTSTTGTS 232
R + + + S + TP + P TT T S+ST+ GTS
Sbjct: 626 ERGTTITSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTE-----ATSSSTTAEGTS 677
Score = 28.9 bits (63), Expect = 5.7
Identities = 28/118 (23%), Positives = 49/118 (41%), Gaps = 7/118 (5%)
Query: 121 PIISLDATAASAVWV--SSEAYTSPVSRAQSESEVQVTV----QGDKAVVSFEPSAAPTP 174
P+++ A ++S +S A ++P + + + + V+ + +S P+ TP
Sbjct: 1838 PVVTSTAVSSSPTPAEGTSIATSTPSEGSTALTSIPVSTTTVASSETNTLSTTPAVTSTP 1897
Query: 175 KNRIFAFSFLPSTAPSFPSPTRNP-EVRTPKSATQPQTTETNLQTAPKLSTSTSTTGT 231
S P+TA PT P E R P ++ TT LST+ + T T
Sbjct: 1898 VTTYAQVSSSPTTADGSSMPTSTPREGRPPLTSIPVSTTTVASSEINTLSTTLADTRT 1955
Score = 28.5 bits (62), Expect = 7.4
Identities = 34/148 (22%), Positives = 49/148 (33%), Gaps = 3/148 (2%)
Query: 127 ATAASAVWVSSEAYTSPVSRAQSES-EVQVTVQGDKAVVSFEPSAAPTPKNRIFAFSFLP 185
+T A + + YT + S + + + +S P TP S P
Sbjct: 670 STTAEGTSMPTSTYTEGSTPLTSMPVNTTLVASSEASTLSTTPVDTSTPVTTSTEASSSP 729
Query: 186 STAPSFPSPTRNP-EVRTPKSATQPQTTETNLQTAPKLSTSTSTTGTSHLVKCAEKEKTF 244
+TA PT P E TP ++ T A LST+ T T H+ E +
Sbjct: 730 TTADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLSTTPLDTST-HITTSTEASCSP 788
Query: 245 CVNGGECFMVKDLSNPSRYLCKCPNEFT 272
G + S S L P T
Sbjct: 789 TTTEGTSMPISTPSEGSPLLTSIPVSIT 816
Score = 28.1 bits (61), Expect = 9.7
Identities = 33/122 (27%), Positives = 49/122 (40%), Gaps = 18/122 (14%)
Query: 123 ISLDATAASAVWVSSEA---YTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPTPKNRIF 179
+S A+SA+ S ++PV+ + T +G S PS TP
Sbjct: 2168 VSTTVVASSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTS-TPSEGSTP----- 2221
Query: 180 AFSFLP-STAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAP------KLSTSTSTTGTS 232
F+ +P ST P S TP + P TT T ++P + TST + GT+
Sbjct: 2222 -FTSMPVSTMPVVTSEASTLSA-TPVDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGTT 2279
Query: 233 HL 234
L
Sbjct: 2280 PL 2281
>gi|20070380 neuregulin 4 [Homo sapiens]
Length = 115
Score = 45.8 bits (107), Expect = 4e-05
Identities = 17/47 (36%), Positives = 27/47 (57%), Gaps = 3/47 (6%)
Query: 231 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQ 277
T H C K+FC+NGG C+++ + +P C+C +TG RC+
Sbjct: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSP---FCRCVENYTGARCE 46
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 40.8 bits (94), Expect = 0.001
Identities = 20/49 (40%), Positives = 26/49 (53%), Gaps = 7/49 (14%)
Query: 230 GTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQN 278
G SH C ++ C NGG+C S S Y+C CP FTG RC++
Sbjct: 3841 GISHCPTCRDRP---CQNGGQCHD----SESSSYVCVCPAGFTGSRCEH 3882
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 38.9 bits (89), Expect = 0.005
Identities = 14/34 (41%), Positives = 23/34 (67%), Gaps = 2/34 (5%)
Query: 245 CVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQN 278
C+NGG C + ++ P ++C+CP F+G RCQ+
Sbjct: 1313 CLNGGTCAVASNM--PDGFICRCPPGFSGARCQS 1344
Score = 36.2 bits (82), Expect = 0.035
Identities = 23/56 (41%), Positives = 28/56 (50%), Gaps = 11/56 (19%)
Query: 241 EKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTP-FLSLP 295
EK C NGG C L + C+C + FTG+ CQ YSTS P F+S P
Sbjct: 69 EKNRCQNGGTCVAQAMLGKAT---CRCASGFTGEDCQ-------YSTSHPCFVSRP 114
Score = 33.1 bits (74), Expect = 0.30
Identities = 14/34 (41%), Positives = 18/34 (52%), Gaps = 5/34 (14%)
Query: 245 CVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQN 278
C +GG C L+ P Y C+CP FTG C +
Sbjct: 192 CQHGGTC-----LNLPGSYQCQCPQGFTGQYCDS 220
Score = 32.3 bits (72), Expect = 0.51
Identities = 14/33 (42%), Positives = 18/33 (54%), Gaps = 5/33 (15%)
Query: 245 CVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQ 277
CVN G+C + +R+ C CP FTG CQ
Sbjct: 503 CVNNGQC-----VDKVNRFQCLCPPGFTGPVCQ 530
Score = 32.0 bits (71), Expect = 0.67
Identities = 15/52 (28%), Positives = 25/52 (48%), Gaps = 5/52 (9%)
Query: 229 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 280
TG + + T C+NG +C + +P+ Y C+C FTG C+ +
Sbjct: 525 TGPVCQIDIDDCSSTPCLNGAKC-----IDHPNGYECQCATGFTGVLCEENI 571
Score = 31.2 bits (69), Expect = 1.1
Identities = 14/33 (42%), Positives = 17/33 (51%), Gaps = 4/33 (12%)
Query: 245 CVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQ 277
C+NGG C M+ + Y C C FTG CQ
Sbjct: 115 CLNGGTCHML----SRDTYECTCQVGFTGKECQ 143
Score = 31.2 bits (69), Expect = 1.1
Identities = 13/35 (37%), Positives = 18/35 (51%), Gaps = 3/35 (8%)
Query: 245 CVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNY 279
C +GG C + P Y C+C F+G RC+ Y
Sbjct: 1383 CQHGGSCHPQRQ---PPYYSCQCAPPFSGSRCELY 1414
Score = 30.8 bits (68), Expect = 1.5
Identities = 17/47 (36%), Positives = 25/47 (53%), Gaps = 5/47 (10%)
Query: 232 SHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQN 278
+H ++C + + CVN G C N + Y CKCP F G+ CQ+
Sbjct: 23 AHALQCRDGYEP-CVNEGMCVTYH---NGTGY-CKCPEGFLGEYCQH 64
Score = 30.8 bits (68), Expect = 1.5
Identities = 12/33 (36%), Positives = 18/33 (54%), Gaps = 5/33 (15%)
Query: 245 CVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQ 277
C+NGG+C + Y C+C F G+RC+
Sbjct: 1235 CLNGGQC-----MDRIGGYSCRCLPGFAGERCE 1262
Score = 30.4 bits (67), Expect = 1.9
Identities = 13/33 (39%), Positives = 17/33 (51%), Gaps = 5/33 (15%)
Query: 245 CVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQ 277
C NGG C + + + C C FTGD+CQ
Sbjct: 920 CQNGGSC-----MDGVNTFSCLCLPGFTGDKCQ 947
Score = 30.0 bits (66), Expect = 2.5
Identities = 17/52 (32%), Positives = 22/52 (42%), Gaps = 5/52 (9%)
Query: 229 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 280
TG+ L + E C+N G C + Y C CP +TG CQ V
Sbjct: 1018 TGSFCLHEINECSSHPCLNEGTC-----VDGLGTYRCSCPLGYTGKNCQTLV 1064
Score = 29.6 bits (65), Expect = 3.3
Identities = 13/36 (36%), Positives = 18/36 (50%), Gaps = 5/36 (13%)
Query: 245 CVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 280
C NG C V + ++ CKC FTG +C+ V
Sbjct: 153 CANGSTCTTVAN-----QFSCKCLTGFTGQKCETDV 183
Score = 29.3 bits (64), Expect = 4.3
Identities = 12/32 (37%), Positives = 17/32 (53%), Gaps = 5/32 (15%)
Query: 245 CVNGGECFMVKDLSNPSRYLCKCPNEFTGDRC 276
C NGG C + + Y C+CP ++TG C
Sbjct: 269 CQNGGVC-----VDGVNTYNCRCPPQWTGQFC 295
Score = 29.3 bits (64), Expect = 4.3
Identities = 14/46 (30%), Positives = 21/46 (45%), Gaps = 5/46 (10%)
Query: 245 CVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTP 290
C NGG C + Y C C N ++GD C + +++ TP
Sbjct: 309 CQNGGTC-----ANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTP 349
Score = 29.3 bits (64), Expect = 4.3
Identities = 15/36 (41%), Positives = 17/36 (47%), Gaps = 5/36 (13%)
Query: 245 CVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 280
C NGG C D N Y CKC F G C+N +
Sbjct: 958 CKNGGTC---SDYVNS--YTCKCQAGFDGVHCENNI 988
Score = 28.5 bits (62), Expect = 7.4
Identities = 13/33 (39%), Positives = 16/33 (48%), Gaps = 5/33 (15%)
Query: 245 CVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQ 277
C+N G CF + S Y C C +TG CQ
Sbjct: 804 CLNQGTCF-----DDISGYTCHCVLPYTGKNCQ 831
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 38.5 bits (88), Expect = 0.007
Identities = 17/37 (45%), Positives = 21/37 (56%), Gaps = 4/37 (10%)
Query: 244 FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 280
FC NGG C + ++ C C E+TGDRCQ YV
Sbjct: 4292 FCQNGGTCIVTAG----NQPYCHCQPEYTGDRCQYYV 4324
>gi|88702793 slit-like 2 [Homo sapiens]
Length = 673
Score = 38.1 bits (87), Expect = 0.009
Identities = 30/117 (25%), Positives = 45/117 (38%), Gaps = 12/117 (10%)
Query: 185 PSTAPSFPSPTRNPEVRTPKSATQP------QTTETNLQTAPKLSTSTSTTGTSHLVKCA 238
P+T + PT P VR P + + TE + ST+ T G + +
Sbjct: 350 PATTTTATVPTTRPVVREPTALSSSLAPTWLSPTEPATEAPSPPSTAPPTVGP--VPQPQ 407
Query: 239 EKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSLP 295
+ + C+NGG C L C CP FTG C++ + + TP P
Sbjct: 408 DCPPSTCLNGGTCH----LGTRHHLACLCPEGFTGLYCESQMGQGTRPSPTPVTPRP 460
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 37.7 bits (86), Expect = 0.012
Identities = 31/109 (28%), Positives = 44/109 (40%), Gaps = 15/109 (13%)
Query: 187 TAPSFPSPTRNPEVRTPKSAT----QPQTTETNLQTAPKLSTSTSTTGTS-HLVKCAEKE 241
T PSPT P+ P + + N + PK TG L +C E
Sbjct: 4181 TCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEH- 4239
Query: 242 KTFCVNGGECFMVKDLSNPSRY-LCKCPNEFTGDRCQNYVMASFYSTST 289
C NGG C ++PS C+CP FTG +C V A + + ++
Sbjct: 4240 ---CRNGGTC-----AASPSGMPTCRCPTGFTGPKCTQQVCAGYCANNS 4280
Score = 32.7 bits (73), Expect = 0.39
Identities = 14/38 (36%), Positives = 19/38 (50%), Gaps = 4/38 (10%)
Query: 245 CVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 282
C NGG C M + C+CP TG RC+ +V +
Sbjct: 4381 CSNGGSCTMNSKMMPE----CQCPPHMTGPRCEEHVFS 4414
Score = 31.2 bits (69), Expect = 1.1
Identities = 26/96 (27%), Positives = 34/96 (35%), Gaps = 15/96 (15%)
Query: 193 SPTRNPEVRTPKSATQPQTTETNLQT-APKLSTSTSTTGTSHLVKCA----------EKE 241
SP+ P R P T P+ T+ ST T G +C +
Sbjct: 4249 SPSGMPTCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQC 4308
Query: 242 KTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQ 277
+C N G C M D S C+C F G RC+
Sbjct: 4309 SGYCENFGTCQMAADGSRQ----CRCTAYFEGSRCE 4340
>gi|4502199 amphiregulin preproprotein [Homo sapiens]
Length = 252
Score = 37.4 bits (85), Expect = 0.016
Identities = 30/120 (25%), Positives = 47/120 (39%), Gaps = 11/120 (9%)
Query: 164 VSFEPSAAPTPKNRIFAFSFLPSTAPSFPSPTRNPEVRTPKSATQPQ--TTETNLQTAPK 221
VS PS++ + +S P P + VR + PQ T N PK
Sbjct: 66 VSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENTSDKPK 125
Query: 222 LSTSTSTTGTSHLVK-----CAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRC 276
G + + C + + FC++G EC ++ L + CKC E+ G+RC
Sbjct: 126 RKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHG-ECKYIEHLEAVT---CKCQQEYFGERC 181
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,007,225
Number of Sequences: 37866
Number of extensions: 676570
Number of successful extensions: 4434
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 194
Number of HSP's that attempted gapping in prelim test: 3288
Number of HSP's gapped (non-prelim): 1215
length of query: 296
length of database: 18,247,518
effective HSP length: 102
effective length of query: 194
effective length of database: 14,385,186
effective search space: 2790726084
effective search space used: 2790726084
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.