Search of human proteins with 7662270

Search of human proteins with 7662270

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7662270 synaptic vesicle protein 2B homolog [Homo sapiens]
         (683 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7662270 synaptic vesicle protein 2B homolog [Homo sapiens]        1404   0.0  
gi|216548223 synaptic vesicle glycoprotein 2 [Homo sapiens]           895   0.0  
gi|73695465 synaptic vesicle glycoprotein 2C [Homo sapiens]           847   0.0  
gi|24308167 SV2 related protein [Homo sapiens]                        120   4e-27
gi|213021148 SVOP-like isoform 1 [Homo sapiens]                       105   2e-22
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]            79   2e-14
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]        72   2e-12
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...    71   3e-12
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...    71   3e-12
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]           70   6e-12
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]           68   3e-11
gi|21361449 solute carrier family 2 (facilitated glucose transpo...    67   7e-11
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]            66   1e-10
gi|166064021 solute carrier family 22 (organic anion transporter...    65   3e-10
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...    61   3e-09
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...    61   3e-09
gi|203098995 solute carrier family 2 (facilitated glucose transp...    60   5e-09
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]        60   7e-09
gi|223029432 solute carrier family 2 (facilitated glucose transp...    60   9e-09
gi|223029430 solute carrier family 2 (facilitated glucose transp...    60   9e-09
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...    59   1e-08
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...    59   1e-08
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...    59   1e-08
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...    59   1e-08
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]           57   6e-08
gi|33457322 SVOP-like isoform 2 [Homo sapiens]                         56   1e-07
gi|157426885 organic cation transporter like 4 [Homo sapiens]          55   2e-07
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]           55   3e-07
gi|190684655 glucose transporter protein 10 isoform a [Homo sapi...    53   1e-06
gi|68226420 glucose transporter protein 10 isoform c [Homo sapiens]    53   1e-06

>gi|7662270 synaptic vesicle protein 2B homolog [Homo sapiens]
          Length = 683

 Score = 1404 bits (3634), Expect = 0.0
 Identities = 683/683 (100%), Positives = 683/683 (100%)

Query: 1   MDDYKYQDNYGGYAPSDGYYRGNESNPEEDAQSDVTEGHDEEDEIYEGEYQGIPHPDDVK 60
           MDDYKYQDNYGGYAPSDGYYRGNESNPEEDAQSDVTEGHDEEDEIYEGEYQGIPHPDDVK
Sbjct: 1   MDDYKYQDNYGGYAPSDGYYRGNESNPEEDAQSDVTEGHDEEDEIYEGEYQGIPHPDDVK 60

Query: 61  AKQAKMAPSRMDSLRGQTDLMAERLEDEEQLAHQYETIMDECGHGRFQWILFFVLGLALM 120
           AKQAKMAPSRMDSLRGQTDLMAERLEDEEQLAHQYETIMDECGHGRFQWILFFVLGLALM
Sbjct: 61  AKQAKMAPSRMDSLRGQTDLMAERLEDEEQLAHQYETIMDECGHGRFQWILFFVLGLALM 120

Query: 121 ADGVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSM 180
           ADGVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSM
Sbjct: 121 ADGVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSM 180

Query: 181 SLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLG 240
           SLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLG
Sbjct: 181 SLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLG 240

Query: 241 IFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPES 300
           IFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPES
Sbjct: 241 IFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPES 300

Query: 301 PRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWY 360
           PRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWY
Sbjct: 301 PRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWY 360

Query: 361 QRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQD 420
           QRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQD
Sbjct: 361 QRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQD 420

Query: 421 EEYKSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFE 480
           EEYKSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFE
Sbjct: 421 EEYKSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFE 480

Query: 481 DVTSTDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLEQDNDFLIYL 540
           DVTSTDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLEQDNDFLIYL
Sbjct: 481 DVTSTDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLEQDNDFLIYL 540

Query: 541 VSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFC 600
           VSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFC
Sbjct: 541 VSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFC 600

Query: 601 GTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLA 660
           GTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLA
Sbjct: 601 GTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLA 660

Query: 661 AASLVGGGLIALRLPETREQVLM 683
           AASLVGGGLIALRLPETREQVLM
Sbjct: 661 AASLVGGGLIALRLPETREQVLM 683


>gi|216548223 synaptic vesicle glycoprotein 2 [Homo sapiens]
          Length = 742

 Score =  895 bits (2314), Expect = 0.0
 Identities = 438/682 (64%), Positives = 528/682 (77%), Gaps = 13/682 (1%)

Query: 14  APSDGYYRGNESNPEED--AQSDVTEGHDEEDEIYEGEYQGIPHPDDVKAKQAKMAPSRM 71
           APSDGYYRG  +  EE+  A SD TEGHDE+DEIYEGEYQGIP  +     +     + +
Sbjct: 60  APSDGYYRGEGTQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPL 119

Query: 72  DSLRGQTDL---------MAERLEDEEQLAHQYETIMDECGHGRFQWILFFVLGLALMAD 122
             +RG              A+R ++ E+LA QYE I+ ECGHGRFQW L+FVLGLALMAD
Sbjct: 120 AGVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMAD 179

Query: 123 GVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSL 182
           GVEVFVV F LPSAEKDMCLS S KGMLG+IVYLGMM GAF+ GGLAD+LGR++ L +SL
Sbjct: 180 GVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISL 239

Query: 183 AVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIF 242
           +VN+ FA  SSFVQGYG FLFCRL+SG+GIGG++PIVF+YFSEFL++EKRGEHLSWL +F
Sbjct: 240 SVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMF 299

Query: 243 WMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPR 302
           WM GG+YA+AMAW+IIPHYGW F MG+ Y FHSWRVFV+VCA P   ++ AL   PESPR
Sbjct: 300 WMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPR 359

Query: 303 FLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQR 362
           F LE GKHDEAWM+LKQVHDTNMRAKG PE+VF+V++IKT  Q DE IEIQS TGTWYQR
Sbjct: 360 FFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQR 419

Query: 363 WLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQDEE 422
           W VR  ++  QVW N L C    YR  TL++  VWF M+FSYYGLTVWFPDMIR+ Q  +
Sbjct: 420 WGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVD 479

Query: 423 YKSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDV 482
           Y S+ KVF GE V   T NFT+ENQIH+ G+  NDKF  +  K V FED+ F+ECYFEDV
Sbjct: 480 YASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDV 539

Query: 483 TSTDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLEQDND--FLIYL 540
           TS++T+F+NCT  +T+FYNTDL+E+KF+N R INSTFL  KEGC +D+    +  +++Y 
Sbjct: 540 TSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYF 599

Query: 541 VSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFC 600
           VSFLG+L+VLPGNI+SALLMD+IGRL+M+ GS ++S V CFFL FGNSESAMI   CLF 
Sbjct: 600 VSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFG 659

Query: 601 GTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLA 660
           G SIA+WNALDV+TVELYP+++R TAFG LN LCK  A+LG +IF SFVGITK  PIL A
Sbjct: 660 GVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFA 719

Query: 661 AASLVGGGLIALRLPETREQVL 682
           +A+L  G  +AL+LPETR QVL
Sbjct: 720 SAALALGSSLALKLPETRGQVL 741


>gi|73695465 synaptic vesicle glycoprotein 2C [Homo sapiens]
          Length = 727

 Score =  847 bits (2189), Expect = 0.0
 Identities = 415/681 (60%), Positives = 509/681 (74%), Gaps = 3/681 (0%)

Query: 4   YKYQDNYGGYAPSDGYYRGNESNPEEDAQSDVTEGHDEEDEIYEGEYQGIPHPDDVKAKQ 63
           ++ +++   Y P+   Y G E+N +E + S+ TEGHDE+DEIYEGEYQGIP  +  K   
Sbjct: 49  FQDEEDDDDYYPAGETYNG-EANDDEGS-SEATEGHDEDDEIYEGEYQGIPSMNQAKDSI 106

Query: 64  AKMAPSRMDSLRGQTDLMAERLEDEEQLAHQYETIMDECGHGRFQWILFFVLGLALMADG 123
             +   + D  + + +L +ER  DEE+LA QYE I+ ECGHGRFQW LFFVLG+ALMADG
Sbjct: 107 VSVGQPKGDEYKDRRELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADG 166

Query: 124 VEVFVVSFALPSAEKDMCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSLA 183
           VEVFVV F LPSAE D+C+ +S  G LG IVYLGMM GAF  GGLADK+GRK+ L + ++
Sbjct: 167 VEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMS 226

Query: 184 VNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFW 243
           VN  FA LSSFVQGYG FLFCRL+SG GIGGA+P VF+YF+E L+REKRGEHLSWL +FW
Sbjct: 227 VNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFW 286

Query: 244 MTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRF 303
           M GG+YASAMAW+IIPHYGW FSMG+ Y FHSWRVFVIVCALPC  S+VAL FMPESPRF
Sbjct: 287 MIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRF 346

Query: 304 LLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRW 363
           LLE+GKHDEAWMILK +HDTNMRA+G PEKVFTV+ IKTPKQ+DE IEI+S TGTWY+R 
Sbjct: 347 LLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRC 406

Query: 364 LVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQDEEY 423
            VR +T    +W   + C   P R NT+ L +VWF ++F YYGL+VWFPD+I+  Q +EY
Sbjct: 407 FVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEY 466

Query: 424 KSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDVT 483
               +    +     TINFTMENQIH   +  N +F  + FK V F+D+ F  C FEDVT
Sbjct: 467 ALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVT 526

Query: 484 STDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLEQD-NDFLIYLVS 542
           S +TYFKNCT   T+F NTD   +KFI+  F N +F   K GC +  + D + + IY V+
Sbjct: 527 SVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVN 586

Query: 543 FLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGT 602
           FLG+L+VLPGNI+SALLMDRIGRL M+GGSM++S + CFFL+FG SES MIG  CL+ G 
Sbjct: 587 FLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGL 646

Query: 603 SIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAA 662
           +I+AWN+LDV+TVELYPT++RAT FG LN LCK  A+LGN IF S V ITK +PILLA+ 
Sbjct: 647 TISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLAST 706

Query: 663 SLVGGGLIALRLPETREQVLM 683
            LV GGL+ L LP+TR QVLM
Sbjct: 707 VLVCGGLVGLCLPDTRTQVLM 727


>gi|24308167 SV2 related protein [Homo sapiens]
          Length = 548

 Score =  120 bits (301), Expect = 4e-27
 Identities = 86/314 (27%), Positives = 146/314 (46%), Gaps = 48/314 (15%)

Query: 96  ETIMDECGHGRFQWILFFVLGLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVY 155
           E  ++  G G+FQW L  + GLA MAD +E+ ++S   P    +  L S +  +L  +V+
Sbjct: 71  EDAVEAIGFGKFQWKLSVLTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVF 130

Query: 156 LGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGA 215
           +GMM+ + + G ++D+ GRK  L +S+     +  LS+F   Y   L  R + G GIGG 
Sbjct: 131 VGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLVGFGIGG- 189

Query: 216 LPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHS 275
           +P     ++EFL  + R + +  + +FW  G ++   +A  ++P  G             
Sbjct: 190 VPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLG------------- 236

Query: 276 WRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVF 335
           WR  +I+ A+P  +  V   ++PES R+ +  G  ++A   LK++   N    G P  + 
Sbjct: 237 WRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATEN----GAPMPLG 292

Query: 336 TVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAV 395
            +            I  Q   G        + + +F              +R  TL+L  
Sbjct: 293 KL-----------IISRQEDRG--------KMRDLFTP-----------HFRWTTLLLWF 322

Query: 396 VWFAMAFSYYGLTV 409
           +WF+ AFSYYGL +
Sbjct: 323 IWFSNAFSYYGLVL 336



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 33/118 (27%), Positives = 56/118 (47%), Gaps = 2/118 (1%)

Query: 546 SLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIA 605
           +LS  PG +++  ++DR+GR K +    +I + C   LF     + +     +       
Sbjct: 380 TLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSFCSLLLFICVGRNVLTLLLFIARAFISG 439

Query: 606 AWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAAS 663
            + A  V T E+YPT  RA   G  +G+ + GA++  T F + V +   V + LA  S
Sbjct: 440 GFQAAYVYTPEVYPTATRALGLGTCSGMARVGALI--TPFIAQVMLESSVYLTLAVYS 495


>gi|213021148 SVOP-like isoform 1 [Homo sapiens]
          Length = 492

 Score =  105 bits (261), Expect = 2e-22
 Identities = 81/312 (25%), Positives = 137/312 (43%), Gaps = 48/312 (15%)

Query: 96  ETIMDECGHGRFQWILFFVLGLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVY 155
           E  ++  G GRF   LF ++G   + + +E+ +++   P    +  L + +  ++  +V+
Sbjct: 35  EDAVETIGFGRFHIALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVALVTTMVF 94

Query: 156 LGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGA 215
            G M  + + G LAD+ GR ++L +S    A F+ L+SF   Y  F+F R + G G+ G 
Sbjct: 95  FGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGH 154

Query: 216 LPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHS 275
              +    +EFL  + RG  L    +FW+ G L    +A  IIP  G             
Sbjct: 155 SQGLIIK-TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIG------------- 200

Query: 276 WRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVF 335
           WR  + V ++P  + +VA KF+PES RF +  G    A   L++V   N           
Sbjct: 201 WRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNR---------- 250

Query: 336 TVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAV 395
             S +   K ++  +E +            RF  +               Y   TL + V
Sbjct: 251 --SVMPEGKLVEPVLEKRG-----------RFADLLD-----------AKYLRTTLQIWV 286

Query: 396 VWFAMAFSYYGL 407
           +W  ++F+YYG+
Sbjct: 287 IWLGISFAYYGV 298



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 41/165 (24%), Positives = 77/165 (46%), Gaps = 8/165 (4%)

Query: 521 EQKEGCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCC 580
           E +  C+  +   +D+   ++S +G +++ P NI+    + R  RL +   S+ +     
Sbjct: 329 ESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGR--RLSL---SITMGCTAL 383

Query: 581 FFLFFG--NSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGA 638
           FFL      S + +IG+  +      A +N + + T E+YPT  RA   G    LC+ GA
Sbjct: 384 FFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGA 443

Query: 639 ILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLP-ETREQVL 682
           ++   I    +  + +  + L ++  V   + A  LP ET+ + L
Sbjct: 444 MVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRAL 488


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 61/275 (22%), Positives = 120/275 (43%), Gaps = 41/275 (14%)

Query: 140 MCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYG 199
           +C    K  +   + ++G++ G+FI G L+D+ GRK VL +++ +   F+ L  F + + 
Sbjct: 135 VCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFE 194

Query: 200 AFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIP 259
            F+   ++ G+G        F   +E L +  R        IF   G     A  + ++P
Sbjct: 195 MFVVLFVLVGMGQISNYVAAFVLGTEILGKSVR-------IIFSTLGVCIFYAFGYMVLP 247

Query: 260 HYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQ 319
            +         Y    WR+ ++   +P  + +    F+PESPR+L+  G+ +EA +I+++
Sbjct: 248 LFA--------YFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRK 299

Query: 320 VHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNAL 379
               N         +   S I  P ++ +     SS        L   +T     W+   
Sbjct: 300 AAKAN--------GIVVPSTIFDPSELQDL----SSKKQQSHNILDLLRT-----WN--- 339

Query: 380 YCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDM 414
                  RM T++  ++W  ++  Y+GL++  P++
Sbjct: 340 ------IRMVTIMSIMLWMTISVGYFGLSLDTPNL 368



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 30/142 (21%), Positives = 64/142 (45%), Gaps = 3/142 (2%)

Query: 538 IYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQC 597
           I++  FL ++  +P  +++ LL+  + R   +  ++ +      F+     +   +    
Sbjct: 372 IFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVL 431

Query: 598 LFCGTS--IAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVV 655
           +  G     AA++ + V T ELYPT  R    G+ +   + G+IL +  F       + +
Sbjct: 432 VMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSIL-SPYFVYLGAYDRFL 490

Query: 656 PILLAAASLVGGGLIALRLPET 677
           P +L  +  +   ++ L LPE+
Sbjct: 491 PYILMGSLTILTAILTLFLPES 512


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 72/302 (23%), Positives = 114/302 (37%), Gaps = 52/302 (17%)

Query: 119 LMADGVEV-----FVVSFALPSAEKDMCLSSSKK-GMLGMIVYLGMMAGAFILGGLADKL 172
           L A+G E+     F  SF   ++E  +  + S K        + G+  G    G L+D+ 
Sbjct: 77  LTANGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRF 136

Query: 173 GRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKR 232
           GRK+V     A++  FA  + F   Y  F   R + G+  GG   + F   +E +     
Sbjct: 137 GRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGT--- 193

Query: 233 GEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMV 292
                    +W   G          I  Y         Y   SWR   I+  L  TV  +
Sbjct: 194 --------AYWALAGSIGGLFFAVGIAQYAL-----LGYFIRSWRTLAILVNLQGTVVFL 240

Query: 293 ALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEI 352
              F+PESPR+L   G+  EA   L  +   N + K T       +  ++ ++   F++ 
Sbjct: 241 LSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTHPAN--RSCRETGSFLD- 297

Query: 353 QSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFP 412
                      L R++ +                  +TLIL  +WF  +  YYGLT+   
Sbjct: 298 -----------LFRYRVLLG----------------HTLILMFIWFVCSLVYYGLTLSAG 330

Query: 413 DM 414
           D+
Sbjct: 331 DL 332



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 39/156 (25%), Positives = 68/156 (43%), Gaps = 11/156 (7%)

Query: 538 IYLVSFLGSLSVLPGNIISALLMDR--IGRLKMIGGSMLISAVCCFFLFFGNSES----- 590
           IY    L  L  +P   +   L+++   GR + +   + +  + C  + F   +      
Sbjct: 336 IYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVF 395

Query: 591 AMIGWQCL-FCG--TSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFAS 647
           A++    L   G  T  AA+N + + T ELYPT  R    G  +   + G I+   I  S
Sbjct: 396 AVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFI-PS 454

Query: 648 FVGITKVVPILLAAASLVGGGLIALRLPETREQVLM 683
              +   +P ++  A+ +  GL++L LPET    L+
Sbjct: 455 LKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLL 490


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 65/255 (25%), Positives = 104/255 (40%), Gaps = 40/255 (15%)

Query: 155 YLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGG 214
           + G++ GA   G L+D+ GR+R+L ++          S+    Y  F   R ++G  + G
Sbjct: 152 FAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAG 211

Query: 215 ALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFH 274
              IV     E+L  E R         FW TGG+   A+                 Y   
Sbjct: 212 FTIIVMPLELEWLDVEHRTVAGVLSSTFW-TGGVMLLAL---------------VGYLIR 255

Query: 275 SWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKV 334
            WR  ++   LPC   +++L ++PES R+LL  G   EA   L  +H   +  +   E  
Sbjct: 256 DWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYL--LHCARLNGRPVCEDS 313

Query: 335 FTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILA 394
           F+   +      +  +   S        +L  F+T   ++   +L CV            
Sbjct: 314 FSQEAVSKVAAGERVVRRPS--------YLDLFRT--PRLRHISLCCV------------ 351

Query: 395 VVWFAMAFSYYGLTV 409
           VVWF + FSYYGL++
Sbjct: 352 VVWFGVNFSYYGLSL 366


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 65/255 (25%), Positives = 104/255 (40%), Gaps = 40/255 (15%)

Query: 155 YLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGG 214
           + G++ GA   G L+D+ GR+R+L ++          S+    Y  F   R ++G  + G
Sbjct: 150 FAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAG 209

Query: 215 ALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFH 274
              IV     E+L  E R         FW TGG+   A+                 Y   
Sbjct: 210 FTIIVMPLELEWLDVEHRTVAGVLSSTFW-TGGVMLLAL---------------VGYLIR 253

Query: 275 SWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKV 334
            WR  ++   LPC   +++L ++PES R+LL  G   EA   L  +H   +  +   E  
Sbjct: 254 DWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYL--LHCARLNGRPVCEDS 311

Query: 335 FTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILA 394
           F+   +      +  +   S        +L  F+T   ++   +L CV            
Sbjct: 312 FSQEAVSKVAAGERVVRRPS--------YLDLFRT--PRLRHISLCCV------------ 349

Query: 395 VVWFAMAFSYYGLTV 409
           VVWF + FSYYGL++
Sbjct: 350 VVWFGVNFSYYGLSL 364


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 54/212 (25%), Positives = 96/212 (45%), Gaps = 18/212 (8%)

Query: 140 MCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYG 199
           +C  + K  +   + ++G++ G+F+ G L+D+ GRK VL  ++AV   F+ L  F   + 
Sbjct: 135 VCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWE 194

Query: 200 AFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIP 259
            F    +I G+G      + F   +E L +  R        IF   G     A+ + ++P
Sbjct: 195 MFTVLFVIVGMGQISNYVVAFILGTEILGKSVR-------IIFSTLGVCTFFAVGYMLLP 247

Query: 260 HYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQ 319
            +         Y    WR+ ++   +P  + +    F+PESPR+L+   +  EA  I+++
Sbjct: 248 LFA--------YFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQK 299

Query: 320 VHDTNMRAKGTPEKVF-TVSNIKTPKQMDEFI 350
               N  A   P  +F +V  +   KQ   FI
Sbjct: 300 AAKMNNIA--VPAVIFDSVEELNPLKQQKAFI 329



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 41/146 (28%), Positives = 68/146 (46%), Gaps = 13/146 (8%)

Query: 539 YLVSFLGSLSVLPGNIISALLMDRIGRLKMI-------GGSMLISAVCCFFLFFGNSESA 591
           YL  FL +L  +P  I + LL+  + R  +I       GG +L   +     +F +    
Sbjct: 371 YLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLV 430

Query: 592 MIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGI 651
           M+G    F  TS  A++ L V T ELYPT  R  A G+ +   + G+I+    F      
Sbjct: 431 MLG---KFGITS--AFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIA-PYFVYLGAY 484

Query: 652 TKVVPILLAAASLVGGGLIALRLPET 677
            +++P ++  +  V  G++ L  PE+
Sbjct: 485 NRMLPYIVMGSLTVLIGILTLFFPES 510


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 65/270 (24%), Positives = 109/270 (40%), Gaps = 38/270 (14%)

Query: 140 MCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYG 199
           +C S+  K M   I   G++ G  +LG L+D+ GR+ +L+ S  + A+  S ++F   + 
Sbjct: 115 VCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFP 174

Query: 200 AFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIP 259
            ++  R + G GI G          E++    R    + LG        Y       I+P
Sbjct: 175 IYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALG--------YCYTFGQFILP 226

Query: 260 HYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQ 319
                   G  Y    WR   +  ++P  V  ++  + PES R+L+  GK  +A  IL++
Sbjct: 227 --------GLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRR 278

Query: 320 VHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNAL 379
           V   N   K    +  ++  +K   Q     EI  +   +    L R   +         
Sbjct: 279 VAVFN--GKKEEGERLSLEELKLNLQK----EISLAKAKYTASDLFRIPML--------- 323

Query: 380 YCVMGPYRMNTLILAVVWFAMAFSYYGLTV 409
                  R  T  L++ WFA  F+YY L +
Sbjct: 324 -------RRMTFCLSLAWFATGFAYYSLAM 346


>gi|21361449 solute carrier family 2 (facilitated glucose
           transporter), member 8 [Homo sapiens]
          Length = 477

 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 65/254 (25%), Positives = 109/254 (42%), Gaps = 26/254 (10%)

Query: 105 GRFQWILFFVLGLALMADGVEVFVVSFALPSAEKDMC----LSSSKKGMLGMIVYLGMMA 160
           GR  ++  F   L  ++ G  +   S A+PS ++       L  +     G +V LG  A
Sbjct: 23  GRRVFLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPPAPRLDDAAASWFGAVVTLGAAA 82

Query: 161 GAFILGGLADKLGRK-RVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIV 219
           G  + G L D+ GRK  +L  S+   A FA +++  Q     L  RL++G+  G A  + 
Sbjct: 83  GGVLGGWLVDRAGRKLSLLLCSVPFVAGFAVITA-AQDVWMLLGGRLLTGLACGVASLVA 141

Query: 220 FAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVF 279
             Y SE      RG   S + +  + G L A    W +                  WR  
Sbjct: 142 PVYISEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVL-----------------EWRWL 184

Query: 280 VIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTP---EKVFT 336
            ++  +P ++ ++ + FMPE+PRFLL   +  EA   L+ +  +    +  P   E+ F 
Sbjct: 185 AVLGCVPPSLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLWGSEQGWEDPPIGAEQSFH 244

Query: 337 VSNIKTPKQMDEFI 350
           ++ ++ P     FI
Sbjct: 245 LALLRQPGIYKPFI 258


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 69/272 (25%), Positives = 108/272 (39%), Gaps = 52/272 (19%)

Query: 140 MCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYG 199
           +C +S    +    V +G   G+  +G +AD+ GRK  L  ++ +NA+   L +    Y 
Sbjct: 142 VCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYT 201

Query: 200 AFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWM---TGGLYASAMAWS 256
             L  RLI G+       I +   +EF+ R  R      +GIF+    T GL   A    
Sbjct: 202 WMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRT----VGIFYQVAYTVGLLVLAGVAY 257

Query: 257 IIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMI 316
            +PH               WR      ALP    ++    +PESPR+L+   K+ EA  I
Sbjct: 258 ALPH---------------WRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRI 302

Query: 317 LKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWD 376
           +K +   N   K  P  +             + + ++  TG              K++  
Sbjct: 303 IKHIAKKN--GKSLPASL-------------QRLRLEEETG--------------KKLNP 333

Query: 377 NALYCVMGPY-RMNTLILAVVWFAMAFSYYGL 407
           + L  V  P  R +T+IL   WF  +  Y GL
Sbjct: 334 SFLDLVRTPQIRKHTMILMYNWFTSSVLYQGL 365



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 51/172 (29%), Positives = 76/172 (44%), Gaps = 7/172 (4%)

Query: 514 FINSTFLEQKEGCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSM 573
           +  S+ L Q    HM L  DN   IYL  F  +L   P   +  L +DRIGR      S 
Sbjct: 355 WFTSSVLYQGLIMHMGLAGDN---IYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASN 411

Query: 574 LISAVCCFFLFF--GNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILN 631
           +++   C    F  G+ +   I   CL       A+  + ++  ELYPT  R     I +
Sbjct: 412 MVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICS 471

Query: 632 GLCKFGAILGNTIFASFVGITKVVPILL-AAASLVGGGLIALRLPETREQVL 682
            +C  G I+   +      I   +P+++     LV GGL+ L LPET+ + L
Sbjct: 472 SMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLL-LPETKGKAL 522


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 63/285 (22%), Positives = 110/285 (38%), Gaps = 51/285 (17%)

Query: 133 LPSAEKDMCLSSSKKGMLGM---IVYLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFA 189
           LPS + +  L   +K +      +   G++ G  + G L D++GRK  +   L +     
Sbjct: 120 LPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIG 179

Query: 190 SLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLY 249
             ++FV  +  ++  R      + G      ++ +  L  E       W+G  W T  + 
Sbjct: 180 LATAFVPSFELYMALRFAVATAVAG-----LSFSNVTLLTE-------WVGPSWRTQAVV 227

Query: 250 ASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGK 309
            +   +S+    G     G  Y F +WR+  I    P  +       +PES R+LL  G+
Sbjct: 228 LAQCNFSL----GQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGR 283

Query: 310 HDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKT 369
            DEA  ++++    N R               +P+ M++ +  ++               
Sbjct: 284 MDEAIQLIQKAASVNRRK-------------LSPELMNQLVPEKTGPS------------ 318

Query: 370 IFKQVWDNALYCVMGP-YRMNTLILAVVWFAMAFSYYGLTVWFPD 413
                  NAL     P  R  TLI+  VWF  +  YYGL++   D
Sbjct: 319 ------GNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGD 357



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 37/148 (25%), Positives = 65/148 (43%), Gaps = 5/148 (3%)

Query: 538 IYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQC 597
           +YL   +     +P    S  +M R GR     G++++  + C  + F  ++  ++    
Sbjct: 362 VYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTML 421

Query: 598 LFCG--TSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVG-ITKV 654
              G   + AA+    V + EL+PT  R T  G++    + G IL  T     +G     
Sbjct: 422 AVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGIL--TPLVILLGEYHAA 479

Query: 655 VPILLAAASLVGGGLIALRLPETREQVL 682
           +P+L+  +  +  GL+   LPET  Q L
Sbjct: 480 LPMLIYGSLPIVAGLLCTLLPETHGQGL 507


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 60/268 (22%), Positives = 104/268 (38%), Gaps = 44/268 (16%)

Query: 140 MCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYG 199
           +C  S K  +    +  G + G+  +G  AD+ GRK  L  ++ VNA    L +F   Y 
Sbjct: 141 VCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYM 200

Query: 200 AFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIP 259
           + L  RL+ G+   G     +   +EF+    R        + +  G +  + +A++ +P
Sbjct: 201 SMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYA-LP 259

Query: 260 HYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQ 319
           H               WR   +  +LP  + ++    +PESPR+LL   ++ EA  I+  
Sbjct: 260 H---------------WRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDH 304

Query: 320 VHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNAL 379
           +   N +      K+ ++    T K    F ++              F+T          
Sbjct: 305 IAQKNGKLPPADLKMLSLEEDVTEKLSPSFADL--------------FRT---------- 340

Query: 380 YCVMGPYRMNTLILAVVWFAMAFSYYGL 407
                  R  T IL  +WF  +  Y GL
Sbjct: 341 ----PRLRKRTFILMYLWFTDSVLYQGL 364



 Score = 37.0 bits (84), Expect = 0.060
 Identities = 25/96 (26%), Positives = 45/96 (46%), Gaps = 5/96 (5%)

Query: 527 HMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFG 586
           HM     N +L +L S   +L  +PG  I+ + +DR+GR+  +  S L++   C  + F 
Sbjct: 367 HMGATSGNLYLDFLYS---ALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFI 423

Query: 587 NSESAMIGWQCLFCGTS--IAAWNALDVITVELYPT 620
           + +   +    +  G      A   + ++  ELYPT
Sbjct: 424 SPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPT 459


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 60/268 (22%), Positives = 104/268 (38%), Gaps = 44/268 (16%)

Query: 140 MCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYG 199
           +C  S K  +    +  G + G+  +G  AD+ GRK  L  ++ VNA    L +F   Y 
Sbjct: 141 VCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYM 200

Query: 200 AFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIP 259
           + L  RL+ G+   G     +   +EF+    R        + +  G +  + +A++ +P
Sbjct: 201 SMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYA-LP 259

Query: 260 HYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQ 319
           H               WR   +  +LP  + ++    +PESPR+LL   ++ EA  I+  
Sbjct: 260 H---------------WRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDH 304

Query: 320 VHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNAL 379
           +   N +      K+ ++    T K    F ++              F+T          
Sbjct: 305 IAQKNGKLPPADLKMLSLEEDVTEKLSPSFADL--------------FRT---------- 340

Query: 380 YCVMGPYRMNTLILAVVWFAMAFSYYGL 407
                  R  T IL  +WF  +  Y GL
Sbjct: 341 ----PRLRKRTFILMYLWFTDSVLYQGL 364



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 42/155 (27%), Positives = 71/155 (45%), Gaps = 7/155 (4%)

Query: 527 HMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFG 586
           HM     N +L +L S   +L  +PG  I+ + +DR+GR+  +  S L++   C  + F 
Sbjct: 367 HMGATSGNLYLDFLYS---ALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFI 423

Query: 587 NSESAMIGWQCLFCGTS--IAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTI 644
           + +   +    +  G      A   + ++  ELYPT  R     + + LC  G I+   I
Sbjct: 424 SPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFI 483

Query: 645 FASFVGITKVVP-ILLAAASLVGGGLIALRLPETR 678
                 + + +P IL A   L+  G + L LPET+
Sbjct: 484 VFRLREVWQALPLILFAVLGLLAAG-VTLLLPETK 517


>gi|203098995 solute carrier family 2 (facilitated glucose
           transporter), member 13 [Homo sapiens]
          Length = 648

 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 49/200 (24%), Positives = 89/200 (44%), Gaps = 15/200 (7%)

Query: 123 GVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSL 182
           G +  VVS A+   ++ + L +  + +L           A   G L    GR+  + ++ 
Sbjct: 96  GYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLAS 155

Query: 183 AVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIF 242
           A+  + +++ +        L  RL+ G+GIG A   V  Y +E      RG  ++   +F
Sbjct: 156 ALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLF 215

Query: 243 WMTGGLYASAM--AWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPES 300
              G  +AS +  A+S +   GW + +G             + A+P  +      F+PES
Sbjct: 216 ITGGQFFASVVDGAFSYLQKDGWRYMLG-------------LAAVPAVIQFFGFLFLPES 262

Query: 301 PRFLLEMGKHDEAWMILKQV 320
           PR+L++ G+  +A  IL Q+
Sbjct: 263 PRWLIQKGQTQKARRILSQM 282


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 61/270 (22%), Positives = 110/270 (40%), Gaps = 38/270 (14%)

Query: 140 MCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYG 199
           +C + + + +   +   G++ GA + G LAD+LG K  L  S    A+  + +++   + 
Sbjct: 129 VCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAATAYFSSFS 188

Query: 200 AFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIP 259
           A+   R + G+   G +    +   E++    R      LG  +  G L  + +A+ I P
Sbjct: 189 AYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILAGVAYLIRP 248

Query: 260 HYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQ 319
                           WR      + P  +  +   ++PES R+LL  GK   A   L++
Sbjct: 249 ----------------WRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQK 292

Query: 320 VHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNAL 379
           V   N R K   E++       T + M  +I+ + ++       L  F+T          
Sbjct: 293 VAAMNGR-KEEGERL-------TKEVMSSYIQSEFASVCTSNSILDLFRT---------- 334

Query: 380 YCVMGPYRMNTLILAVVWFAMAFSYYGLTV 409
                  R  T  L V+WF+ + +YYGL +
Sbjct: 335 ----PAIRKVTCCLMVIWFSNSVAYYGLAM 360



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 33/161 (20%), Positives = 67/161 (41%), Gaps = 4/161 (2%)

Query: 525 GCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLF 584
           G  MDL++     +YLV  L  +   P  +++   M  +GR   +   ++++ +      
Sbjct: 357 GLAMDLQKFG-LSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANM 415

Query: 585 FGNSESAMI--GWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGN 642
           F    + ++      L  G   +++  + + T ELYPT  R    G  +   + G +   
Sbjct: 416 FVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGGLTA- 474

Query: 643 TIFASFVGITKVVPILLAAASLVGGGLIALRLPETREQVLM 683
            +  +    + ++P +   A+ +  GL    L ETR   L+
Sbjct: 475 PLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLV 515


>gi|223029432 solute carrier family 2 (facilitated glucose
           transporter), member 6 isoform 1 [Homo sapiens]
          Length = 507

 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 55/217 (25%), Positives = 87/217 (40%), Gaps = 21/217 (9%)

Query: 113 FVLGLALMADGVEVFVVSFALPSAEK----DMCLSSSKKGMLGMIVYLGMMAGAFILGGL 168
           F   L   + G  +   S  +P+ E+    D+ L+ S+    G +  LG  AG      L
Sbjct: 43  FAAVLGNFSFGYALVYTSPVIPALERSLDPDLHLTKSQASWFGSVFTLGAAAGGLSAMIL 102

Query: 169 ADKLGRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLS 228
            D LGRK  +  S   +A+  +L +   G    L  R ++G   G     +  Y SE   
Sbjct: 103 NDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRTLTGFAGGLTAACIPVYVSEIAP 162

Query: 229 REKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCT 288
              RG   +   +  + G L   A+   ++P                WR   +    P  
Sbjct: 163 PGVRGALGATPQLMAVFGSLSLYALGL-LLP----------------WRWLAVAGEAPVL 205

Query: 289 VSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNM 325
           + ++ L FMP SPRFLL  G+ +EA   L  +  T++
Sbjct: 206 IMILLLSFMPNSPRFLLSRGRDEEALRALAWLRGTDV 242


>gi|223029430 solute carrier family 2 (facilitated glucose
           transporter), member 6 isoform 2 [Homo sapiens]
          Length = 445

 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 55/217 (25%), Positives = 87/217 (40%), Gaps = 21/217 (9%)

Query: 113 FVLGLALMADGVEVFVVSFALPSAEK----DMCLSSSKKGMLGMIVYLGMMAGAFILGGL 168
           F   L   + G  +   S  +P+ E+    D+ L+ S+    G +  LG  AG      L
Sbjct: 43  FAAVLGNFSFGYALVYTSPVIPALERSLDPDLHLTKSQASWFGSVFTLGAAAGGLSAMIL 102

Query: 169 ADKLGRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLS 228
            D LGRK  +  S   +A+  +L +   G    L  R ++G   G     +  Y SE   
Sbjct: 103 NDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRTLTGFAGGLTAACIPVYVSEIAP 162

Query: 229 REKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCT 288
              RG   +   +  + G L   A+   ++P                WR   +    P  
Sbjct: 163 PGVRGALGATPQLMAVFGSLSLYALGL-LLP----------------WRWLAVAGEAPVL 205

Query: 289 VSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNM 325
           + ++ L FMP SPRFLL  G+ +EA   L  +  T++
Sbjct: 206 IMILLLSFMPNSPRFLLSRGRDEEALRALAWLRGTDV 242


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 61/274 (22%), Positives = 110/274 (40%), Gaps = 39/274 (14%)

Query: 137 EKDMCLSSSKKGMLGMIVYL-GMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFV 195
           E D+  S      L   +Y+ G++ GA + G LAD+LGR++VL ++    A   + ++F 
Sbjct: 123 EWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFA 182

Query: 196 QGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAW 255
             +  +   RL+SG+ + G          E++    R    + +G  +  G    + +A+
Sbjct: 183 PNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAY 242

Query: 256 SIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWM 315
           + +PH               WR   ++ + P     +   F  ES R+    G+ D    
Sbjct: 243 A-VPH---------------WRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLR 286

Query: 316 ILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVW 375
            L++V   N + +   +    V      K      E+    G      L+R  T+     
Sbjct: 287 ALQRVARINGKREEGAKLSMEVLRASLQK------ELTMGKGQASAMELLRCPTL----- 335

Query: 376 DNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTV 409
                      R   L L+++WFA +F+YYGL +
Sbjct: 336 -----------RHLFLCLSMLWFATSFAYYGLVM 358



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 13/107 (12%)

Query: 525 GCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFF-- 582
           G  MDL Q     IYL+  +     LP  ++  L+++ +GR      ++L++ +C     
Sbjct: 355 GLVMDL-QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNG 413

Query: 583 -----LFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRA 624
                     +  A++G  CL      A++N + + T ELYPT  RA
Sbjct: 414 VIPQDQSIVRTSLAVLGKGCL-----AASFNCIFLYTGELYPTMIRA 455


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 61/274 (22%), Positives = 110/274 (40%), Gaps = 39/274 (14%)

Query: 137 EKDMCLSSSKKGMLGMIVYL-GMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFV 195
           E D+  S      L   +Y+ G++ GA + G LAD+LGR++VL ++    A   + ++F 
Sbjct: 123 EWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFA 182

Query: 196 QGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAW 255
             +  +   RL+SG+ + G          E++    R    + +G  +  G    + +A+
Sbjct: 183 PNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAY 242

Query: 256 SIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWM 315
           + +PH               WR   ++ + P     +   F  ES R+    G+ D    
Sbjct: 243 A-VPH---------------WRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLR 286

Query: 316 ILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVW 375
            L++V   N + +   +    V      K      E+    G      L+R  T+     
Sbjct: 287 ALQRVARINGKREEGAKLSMEVLRASLQK------ELTMGKGQASAMELLRCPTL----- 335

Query: 376 DNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTV 409
                      R   L L+++WFA +F+YYGL +
Sbjct: 336 -----------RHLFLCLSMLWFATSFAYYGLVM 358



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 13/107 (12%)

Query: 525 GCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFF-- 582
           G  MDL Q     IYL+  +     LP  ++  L+++ +GR      ++L++ +C     
Sbjct: 355 GLVMDL-QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNG 413

Query: 583 -----LFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRA 624
                     +  A++G  CL      A++N + + T ELYPT  RA
Sbjct: 414 VIPQDQSIVRTSLAVLGKGCL-----AASFNCIFLYTGELYPTMIRA 455


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 61/274 (22%), Positives = 110/274 (40%), Gaps = 39/274 (14%)

Query: 137 EKDMCLSSSKKGMLGMIVYL-GMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFV 195
           E D+  S      L   +Y+ G++ GA + G LAD+LGR++VL ++    A   + ++F 
Sbjct: 123 EWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFA 182

Query: 196 QGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAW 255
             +  +   RL+SG+ + G          E++    R    + +G  +  G    + +A+
Sbjct: 183 PNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAY 242

Query: 256 SIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWM 315
           + +PH               WR   ++ + P     +   F  ES R+    G+ D    
Sbjct: 243 A-VPH---------------WRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLR 286

Query: 316 ILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVW 375
            L++V   N + +   +    V      K      E+    G      L+R  T+     
Sbjct: 287 ALQRVARINGKREEGAKLSMEVLRASLQK------ELTMGKGQASAMELLRCPTL----- 335

Query: 376 DNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTV 409
                      R   L L+++WFA +F+YYGL +
Sbjct: 336 -----------RHLFLCLSMLWFATSFAYYGLVM 358



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 41/165 (24%), Positives = 76/165 (46%), Gaps = 14/165 (8%)

Query: 525 GCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFF-- 582
           G  MDL Q     IYL+  +     LP  ++  L+++ +GR      ++L++ +C     
Sbjct: 355 GLVMDL-QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNG 413

Query: 583 -----LFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFG 637
                     +  A++G  CL      A++N + + T ELYPT  R T  G+ + + + G
Sbjct: 414 VIPQDQSIVRTSLAVLGKGCL-----AASFNCIFLYTGELYPTMIRQTGMGMGSTMARVG 468

Query: 638 AILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLPETREQVL 682
           +I+ + + +    +   +P+ +  A  V    + + LPET  Q L
Sbjct: 469 SIV-SPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPL 512


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 61/274 (22%), Positives = 110/274 (40%), Gaps = 39/274 (14%)

Query: 137 EKDMCLSSSKKGMLGMIVYL-GMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFV 195
           E D+  S      L   +Y+ G++ GA + G LAD+LGR++VL ++    A   + ++F 
Sbjct: 123 EWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFA 182

Query: 196 QGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAW 255
             +  +   RL+SG+ + G          E++    R    + +G  +  G    + +A+
Sbjct: 183 PNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAY 242

Query: 256 SIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWM 315
           + +PH               WR   ++ + P     +   F  ES R+    G+ D    
Sbjct: 243 A-VPH---------------WRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLR 286

Query: 316 ILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVW 375
            L++V   N + +   +    V      K      E+    G      L+R  T+     
Sbjct: 287 ALQRVARINGKREEGAKLSMEVLRASLQK------ELTMGKGQASAMELLRCPTL----- 335

Query: 376 DNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTV 409
                      R   L L+++WFA +F+YYGL +
Sbjct: 336 -----------RHLFLCLSMLWFATSFAYYGLVM 358



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 41/165 (24%), Positives = 76/165 (46%), Gaps = 14/165 (8%)

Query: 525 GCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFF-- 582
           G  MDL Q     IYL+  +     LP  ++  L+++ +GR      ++L++ +C     
Sbjct: 355 GLVMDL-QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNG 413

Query: 583 -----LFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFG 637
                     +  A++G  CL      A++N + + T ELYPT  R T  G+ + + + G
Sbjct: 414 VIPQDQSIVRTSLAVLGKGCL-----AASFNCIFLYTGELYPTMIRQTGMGMGSTMARVG 468

Query: 638 AILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLPETREQVL 682
           +I+ + + +    +   +P+ +  A  V    + + LPET  Q L
Sbjct: 469 SIV-SPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPL 512


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 60/272 (22%), Positives = 107/272 (39%), Gaps = 50/272 (18%)

Query: 140 MCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYG 199
           +C+++    +   I+ LG + GAF LG  AD+ GR  +  +S         + +F   + 
Sbjct: 147 VCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFP 206

Query: 200 AFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIP 259
            F+  R + G+   G     +   +E +  ++R      + +F+  G +        I+P
Sbjct: 207 VFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGII--------ILP 258

Query: 260 HYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQ 319
                   G  Y   +W+   +   LP  + ++    +PESPR+L+   K D+A  IL++
Sbjct: 259 --------GIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRR 310

Query: 320 VHDTNMRAKGTPEKVFTVSN--IKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDN 377
           +   N +   +     TV++  +  P  +D                LVR   +       
Sbjct: 311 IAKCNGKYLSSNYSEITVTDEEVSNPSFLD----------------LVRTPQM------- 347

Query: 378 ALYCVMGPYRMNTLILAVVWFAMAFSYYGLTV 409
                    R  TLIL   WF  A  Y GL +
Sbjct: 348 ---------RKCTLILMFAWFTSAVVYQGLVM 370



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 37/145 (25%), Positives = 67/145 (46%), Gaps = 6/145 (4%)

Query: 538 IYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQC 597
           +Y+  F+  +  LPG ++  L ++R+GR      S +++ V C    F     A +    
Sbjct: 379 LYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTV 438

Query: 598 LFCGTS--IAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVV 655
              G      A+  + ++  ELYPT  R     + +GLC FG I+   +      +   +
Sbjct: 439 ATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLEL 498

Query: 656 PILL--AAASLVGGGLIALRLPETR 678
           P+++    AS+ GG  + + LPET+
Sbjct: 499 PLIIFGILASICGG--LVMLLPETK 521


>gi|33457322 SVOP-like isoform 2 [Homo sapiens]
          Length = 340

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 41/165 (24%), Positives = 77/165 (46%), Gaps = 8/165 (4%)

Query: 521 EQKEGCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCC 580
           E +  C+  +   +D+   ++S +G +++ P NI+    + R  RL +   S+ +     
Sbjct: 177 ESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGR--RLSL---SITMGCTAL 231

Query: 581 FFLFFG--NSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGA 638
           FFL      S + +IG+  +      A +N + + T E+YPT  RA   G    LC+ GA
Sbjct: 232 FFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGA 291

Query: 639 ILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLP-ETREQVL 682
           ++   I    +  + +  + L ++  V   + A  LP ET+ + L
Sbjct: 292 MVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRAL 336



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 47/184 (25%), Positives = 73/184 (39%), Gaps = 47/184 (25%)

Query: 224 SEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVC 283
           +EFL  + RG  L    +FW+ G L    +A  IIP  GW             R  + V 
Sbjct: 10  TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGW-------------RWLIRVA 56

Query: 284 ALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTP 343
           ++P  + +VA KF+PES RF +  G    A   L++V   N             S +   
Sbjct: 57  SIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNR------------SVMPEG 104

Query: 344 KQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFS 403
           K ++  +E +            RF  +               Y   TL + V+W  ++F+
Sbjct: 105 KLVEPVLEKRG-----------RFADLLD-----------AKYLRTTLQIWVIWLGISFA 142

Query: 404 YYGL 407
           YYG+
Sbjct: 143 YYGV 146


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 61/271 (22%), Positives = 115/271 (42%), Gaps = 47/271 (17%)

Query: 140 MCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYG 199
           +C   +KK    ++   G+  G+ I   + DK+GR   + +SL     F   ++F+  + 
Sbjct: 176 VCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFH 235

Query: 200 AFLFCRL-ISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSII 258
            +LF R  IS   +G A+  + +  +E+L  E R   +     F+  G +  + +A+S +
Sbjct: 236 LYLFFRFGISQSVVGYAISSI-SLATEWLVGEHRAHAIILGHCFFAVGAVLLTGIAYS-L 293

Query: 259 PHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILK 318
           PH               W++  +V  +     +  +  +PESPR+L+  GK  EA  +L 
Sbjct: 294 PH---------------WQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVL- 337

Query: 319 QVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNA 378
             +  ++  K  P  +           +DE               L R K     V D  
Sbjct: 338 -CYAASVNKKTIPSNL-----------LDEL-------------QLPRKKVTRASVLD-- 370

Query: 379 LYCVMGPYRMNTLILAVVWFAMAFSYYGLTV 409
            +C        TL+++ VWF ++++Y+ L++
Sbjct: 371 -FCKNRQLCKVTLVMSCVWFTVSYTYFTLSL 400



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 40/154 (25%), Positives = 66/154 (42%), Gaps = 20/154 (12%)

Query: 546 SLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFF--GNSESAMIGW-QC----- 597
           S+  +P  +    L+ +IGR   +  ++L + + C  L F     +   + W +C     
Sbjct: 417 SIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATEL 476

Query: 598 --------LFCGTSIAAW-NALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASF 648
                   +    S+AA      + T EL PT  RAT  G+++     GAIL  TI +  
Sbjct: 477 KSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAILSLTIISQ- 535

Query: 649 VGITKVVPILLAAASLVGGGLIALRLPETREQVL 682
                ++PI L     +    ++  LPETR+Q L
Sbjct: 536 --TPSLLPIFLCCVLAIVAFSLSSLLPETRDQPL 567


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 61/270 (22%), Positives = 110/270 (40%), Gaps = 43/270 (15%)

Query: 140 MCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYG 199
           +C S   K +   I   G++ G+FI G L+ + GRK +LS      A   + + F   + 
Sbjct: 135 VCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFV 194

Query: 200 AFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIP 259
            +   R ++  G+ G          E+ +  +R   ++ +G  +  G      +A+++  
Sbjct: 195 IYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFAL-- 252

Query: 260 HYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQ 319
                           WR   +  ++P     +   ++PES R+L+  GK D+A   L++
Sbjct: 253 --------------RDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRK 298

Query: 320 VHDTN--MRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDN 377
           V   N    AK    +V  +S++K         E+ S+                + V D 
Sbjct: 299 VARINGHKEAKNLTIEVL-MSSVKE--------EVASAKEP-------------RSVLD- 335

Query: 378 ALYCVMGPYRMNTLILAVVWFAMAFSYYGL 407
            L+CV    R  +  + VV F++  SYYGL
Sbjct: 336 -LFCV-PVLRWRSCAMLVVNFSLLISYYGL 363



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 43/166 (25%), Positives = 77/166 (46%), Gaps = 3/166 (1%)

Query: 515 INSTFLEQKEGCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSML 574
           +N + L    G   DL+     +  L +  G++  L G   +ALL+  +GR  +  GS  
Sbjct: 352 VNFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFL-GRATTALLLSFLGRRTIQAGSQA 410

Query: 575 IS--AVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNG 632
           ++  A+    L   + ++  + +  L  G    +   L +   EL+PT  R TA GIL+ 
Sbjct: 411 MAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHT 470

Query: 633 LCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLPETR 678
           + + GA++G  I  S   +  + P+L    S+    ++   LPET+
Sbjct: 471 VGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQ 516


>gi|190684655 glucose transporter protein 10 isoform a [Homo
           sapiens]
          Length = 503

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 44/153 (28%), Positives = 69/153 (45%), Gaps = 14/153 (9%)

Query: 156 LGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYGAF---LFCRLISGIGI 212
           LG + GA + G LA  LGRK+ L ++     S A L  F +  G+F   +  RL+ G+  
Sbjct: 83  LGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNA 142

Query: 213 GGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYH 272
           G ++ I   Y  E   +E RG       IF   G +    +        G    +G    
Sbjct: 143 GVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVV--------GLRELLGGP-- 192

Query: 273 FHSWRVFVIVCALPCTVSMVALKFMPESPRFLL 305
             +W + +  C +P  + + +L  +PESPR+LL
Sbjct: 193 -QAWPLLLASCLVPGALQLASLPLLPESPRYLL 224


>gi|68226420 glucose transporter protein 10 isoform c [Homo sapiens]
          Length = 496

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 44/153 (28%), Positives = 69/153 (45%), Gaps = 14/153 (9%)

Query: 156 LGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYGAF---LFCRLISGIGI 212
           LG + GA + G LA  LGRK+ L ++     S A L  F +  G+F   +  RL+ G+  
Sbjct: 76  LGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNA 135

Query: 213 GGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYH 272
           G ++ I   Y  E   +E RG       IF   G +    +        G    +G    
Sbjct: 136 GVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVV--------GLRELLGGP-- 185

Query: 273 FHSWRVFVIVCALPCTVSMVALKFMPESPRFLL 305
             +W + +  C +P  + + +L  +PESPR+LL
Sbjct: 186 -QAWPLLLASCLVPGALQLASLPLLPESPRYLL 217


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.140    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,932,042
Number of Sequences: 37866
Number of extensions: 1088338
Number of successful extensions: 4423
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 4173
Number of HSP's gapped (non-prelim): 181
length of query: 683
length of database: 18,247,518
effective HSP length: 109
effective length of query: 574
effective length of database: 14,120,124
effective search space: 8104951176
effective search space used: 8104951176
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.