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Search of human proteins with 7657265
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7657265 fem-1 homolog b [Homo sapiens]
(627 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7657265 fem-1 homolog b [Homo sapiens] 1260 0.0
gi|17864094 feminization 1 homolog a [Homo sapiens] 426 e-119
gi|24308163 fem-1 homolog a [Homo sapiens] 374 e-103
gi|169218177 PREDICTED: similar to fem-1 homolog a, partial [Hom... 131 2e-30
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 119 6e-27
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 119 6e-27
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 119 6e-27
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 119 6e-27
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 119 6e-27
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 118 2e-26
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 113 6e-25
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 113 6e-25
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 113 6e-25
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 104 3e-22
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 104 3e-22
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 103 6e-22
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 102 1e-21
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 102 1e-21
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 97 6e-20
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 97 6e-20
gi|34304381 inversin isoform a [Homo sapiens] 97 6e-20
gi|34304379 inversin isoform b [Homo sapiens] 97 6e-20
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 96 8e-20
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 95 2e-19
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 95 2e-19
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 94 5e-19
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 93 8e-19
gi|140161500 ankyrin repeat and sterile alpha motif domain conta... 91 2e-18
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 91 2e-18
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 91 2e-18
>gi|7657265 fem-1 homolog b [Homo sapiens]
Length = 627
Score = 1260 bits (3261), Expect = 0.0
Identities = 627/627 (100%), Positives = 627/627 (100%)
Query: 1 MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAK 60
MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAK
Sbjct: 1 MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAK 60
Query: 61 VVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVT 120
VVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVT
Sbjct: 61 VVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVT 120
Query: 121 NSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADP 180
NSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADP
Sbjct: 121 NSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADP 180
Query: 181 NAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLS 240
NAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLS
Sbjct: 181 NAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLS 240
Query: 241 HADCDRRSRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIH 300
HADCDRRSRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIH
Sbjct: 241 HADCDRRSRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIH 300
Query: 301 AYGNRTECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEF 360
AYGNRTECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEF
Sbjct: 301 AYGNRTECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEF 360
Query: 361 EQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQ 420
EQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQ
Sbjct: 361 EQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQ 420
Query: 421 SMNRVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPR 480
SMNRVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPR
Sbjct: 421 SMNRVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPR 480
Query: 481 TREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIV 540
TREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIV
Sbjct: 481 TREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIV 540
Query: 541 QYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCL 600
QYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCL
Sbjct: 541 QYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCL 600
Query: 601 AARAVRANDINYQDQIPRTLEEFVGFH 627
AARAVRANDINYQDQIPRTLEEFVGFH
Sbjct: 601 AARAVRANDINYQDQIPRTLEEFVGFH 627
>gi|17864094 feminization 1 homolog a [Homo sapiens]
Length = 617
Score = 426 bits (1095), Expect = e-119
Identities = 254/632 (40%), Positives = 374/632 (59%), Gaps = 34/632 (5%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
V+ AA +GK+ L LL ++S+ ++ L+ + +TPL++AAR GH +V LLE
Sbjct: 7 VFNAARDGKLRLLTKLLASKSKEEVSSLIS----EKTNGATPLLMAARYGHLDMVEFLLE 62
Query: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
+ G+V FDG I+GA LW A+ AGH +VV+ L++HGA+VN+TT+TNSTPLRA
Sbjct: 63 QCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRA 122
Query: 128 ACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCG 187
ACFDG L+IVKYLVE+ A++ ++N++ +TCLMI+ YKGH ++ +YLLE+ AD N K+ G
Sbjct: 123 ACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKG 182
Query: 188 ATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRR 247
TALH AE+G +DI+K L+ + A + +G+GMTPL A+ + ++V+ L HA +
Sbjct: 183 NTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKT 242
Query: 248 SRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPP-IHAYGNRT 306
RI ALELLGA+F + + D++ Y AM R+ D NI+ K V I AY
Sbjct: 243 ERINALELLGATFVDKKR--DLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAK 300
Query: 307 ECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKL 366
E + +ELE + D D + M+ L++RERILG + D S+ I YRGAVYAD+ F++CI L
Sbjct: 301 EVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINL 360
Query: 367 WLHALHLRQKG----NRNTHKDLLRFAQVFSQMIH------LNETVKAPDIECVLRCSVL 416
W +AL ++Q + T LL FA++FS M+ L TV D+ +L SVL
Sbjct: 361 WKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVL 420
Query: 417 EIEQSMNRVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIH 476
EIE+++ + + +D N L L+L+C+ K C+ E + IY +
Sbjct: 421 EIERAIKQTQCPADPLQLNKA------LSIILHLICLLEKVPCTLEQDHFKKQTIYRFLK 474
Query: 477 LDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSAL 536
L PR + F+ LHLAV+ NT + VC FP+ VT +L++CGA+VN D++ NS L
Sbjct: 475 LHPRGKNNFSPLHLAVDKNTTCVGRY--PVCKFPSLQVTAILIECGADVNVRDSDDNSPL 532
Query: 537 HIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLD-KSTTGVSEILLKTQMKM 595
HI N P D + L L+++GAH D TN +T D +++ L++
Sbjct: 533 HIAALNNHP--DIMNL------LIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHT 584
Query: 596 SLKCLAARAVRANDINYQDQIPRTLEEFVGFH 627
+L+CLAAR + + I Y+ IP LE FV H
Sbjct: 585 TLQCLAARVIVNHRIYYKGHIPEKLETFVSLH 616
>gi|24308163 fem-1 homolog a [Homo sapiens]
Length = 669
Score = 374 bits (960), Expect = e-103
Identities = 244/688 (35%), Positives = 370/688 (53%), Gaps = 93/688 (13%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
VY AA +GK+ L LL RS ++ L G V+ G TPL+IAAR GH VV L++
Sbjct: 7 VYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGG----TPLLIAARYGHLDVVEYLVD 62
Query: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
+ G+V FDG I+GA LW A+ AGH +VV+ L+ GA+VN TT TNSTPLRA
Sbjct: 63 RCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRA 122
Query: 128 ACFDGRLDIVKYLV-ENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHC 186
ACFDG L++V+YLV E+ A++ +AN++ +TCLMI+ YKGH ++ RYLLEQ A N ++
Sbjct: 123 ACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAK 182
Query: 187 GATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLL------- 239
G TALH AE+G ++I++ L+ +A + +G+GMTPL A+ + ++VE L+
Sbjct: 183 GNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQE 242
Query: 240 ------------------------------------------SHADC---DRRSRIEALE 254
S+ C R + +EALE
Sbjct: 243 QVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEALE 302
Query: 255 LLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQEL 314
LLGA++ + + D++ + AM R Q G+ + + E + AY E +EL
Sbjct: 303 LLGATYVDKKR--DLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYSREVNTTEEL 360
Query: 315 ESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLR 374
E++ D D + M+ L++RERILG + D S+ I YRGAVYAD+ FE+CI+LW +AL ++
Sbjct: 361 EALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQ 420
Query: 375 QKG----NRNTHKDLLRFAQVFSQMIH-------LNETVKAPDIECVLRCSVLEIEQSMN 423
Q + T L FA++FS ++ L + D+ VL V E+E+++
Sbjct: 421 QSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQ 480
Query: 424 RVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTRE 483
+ D+ + L L+L+ + K +C+ + ++ +Y L+ PR +
Sbjct: 481 LPREPGDS------AQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKN 534
Query: 484 GFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYN 543
GFT LH+AV+ +T + V FP+ V K+LLDCGA+ ++ D + N+ LHI Q N
Sbjct: 535 GFTPLHMAVDKDT--TNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNN 592
Query: 544 RPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMK----MSLKC 599
P +I+ +L+EAGAH D TN KT + ++L + M+ ++L+C
Sbjct: 593 CP--------AIMNALIEAGAHMDATNAFKKTAYELLD---EKLLARGTMQPFNYVTLQC 641
Query: 600 LAARAVRANDINYQDQIPRTLEEFVGFH 627
LAARA+ N I Y+ IP LE F+ H
Sbjct: 642 LAARALDKNKIPYKGFIPEDLEAFIELH 669
>gi|169218177 PREDICTED: similar to fem-1 homolog a, partial [Homo
sapiens]
Length = 287
Score = 131 bits (330), Expect = 2e-30
Identities = 97/301 (32%), Positives = 152/301 (50%), Gaps = 34/301 (11%)
Query: 342 DVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKG----NRNTHKDLLRFAQVFSQMIH 397
D S+ I YRGAVYAD+ E I+LW +AL ++Q + L FA++FS ++
Sbjct: 6 DTSYCIRYRGAVYADSGNIECYIRLWKYALDMQQSNLEPLTPMSASSFLSFAELFSYVLQ 65
Query: 398 -------LNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDNYECNLYTFLYL 450
L + D+ VL V E+E ++ ++ D+ N L L+L
Sbjct: 66 DPAAKGSLGTQIGFADLMGVLTKRVREVEWALQLLREPRDSAQFNKA------LAIILHL 119
Query: 451 VCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFP 510
+ + K +C+ + ++ IY L+ PR + GFT LH+AV+ +T + V FP
Sbjct: 120 LYLLEKVECTPSQEHLKHQTIYRLLKCAPRGKNGFTPLHMAVDKDT--TNVGRYPVGRFP 177
Query: 511 NALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTN 570
+ V K+L DCGA+ ++ D + N+ LHI Q N P +I+ +L EAGAH D TN
Sbjct: 178 SLHVVKVLFDCGADRDSRDFDNNTPLHIAAQNNCP--------AIVNALTEAGAHMDATN 229
Query: 571 KQNKTPLDKSTTGVSEILLKTQMK----MSLKCLAARAVRANDINYQDQIPRTLEEFVGF 626
KT + ++L + M+ ++L+CLAA+A+ N I Y+ IP LE F+
Sbjct: 230 AFKKTAYELLE---EKLLARGTMQPFNYVTLQCLAAQALDKNKIPYKGFIPEDLEAFIEL 286
Query: 627 H 627
H
Sbjct: 287 H 287
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 119 bits (299), Expect = 6e-27
Identities = 83/228 (36%), Positives = 116/228 (50%), Gaps = 18/228 (7%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL IA + H +V+ LLL+ TG D G T L A+ GH +VK L
Sbjct: 406 TPLHIACKKNHVRVMELLLK--------TGA-SIDAVTESGLTPLHVASFMGHLPIVKNL 456
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ GA+ N + V TPL A G ++ KYL++N A ++ K D T L AA GHT
Sbjct: 457 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 516
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAA-IVVNGHGMTPLKVA 226
++V+ LLE A+PN G T LH AA GH++ V L++ A+ + G TPL VA
Sbjct: 517 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 576
Query: 227 AESCKADVVELLL---SHADCDRRSRIEALELLGASFANDRENYDIIK 271
A+ K V ELLL +H + ++ + L + A N DI+K
Sbjct: 577 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHV-----AVHHNNLDIVK 619
Score = 108 bits (270), Expect = 1e-23
Identities = 133/558 (23%), Positives = 219/558 (39%), Gaps = 88/558 (15%)
Query: 48 TPLIIAARNGHAKVVRLLLEH----------------YRVQTQQTGTVRF--------DG 83
TPL AARNGH ++ +LL+H Q VR D
Sbjct: 307 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 366
Query: 84 YVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVEN 143
+D T L AA GH V K+L+ GA N + TPL AC + +++ L++
Sbjct: 367 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 426
Query: 144 NANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIV 203
A+I + T L +A++ GH +V+ LL++ A PN T LH AA AGH ++
Sbjct: 427 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 486
Query: 204 KELIKWRAAIVVNG-HGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFAN 262
K L++ +A + TPL AA ++V+LLL + A L + +
Sbjct: 487 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN---------NANPNLATTAGH 537
Query: 263 DRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRD 322
+ + + LA+LE+ + + K+ P+H + R + L +
Sbjct: 538 TPLHIAAREGHVETVLALLEK-EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 596
Query: 323 ALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLW--LHALHLRQKGNRN 380
A GL + +N+D+ ++ RG W LH+ K N+
Sbjct: 597 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGG--------SPHSPAWNGYTPLHIAAKQNQ- 647
Query: 381 THKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDNY 440
+V ++ + A ++ V + E V + + + N
Sbjct: 648 --------VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK 699
Query: 441 ECNLYTFLYLVCISTKTQCSEEDQCKI-NKQIYNLIHLDPRTREGFTLLHLAVNSNTPVD 499
+ T L+LV ++E + + I + + +D TR G+T LH+A +
Sbjct: 700 --SGLTPLHLV--------AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH------ 743
Query: 500 DFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISL 559
+ N + K LL A+VNA G S LH Q +D +TL L
Sbjct: 744 ---------YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH--TDIVTL------L 786
Query: 560 VEAGAHTDMTNKQNKTPL 577
++ GA + + TPL
Sbjct: 787 LKNGASPNEVSSDGTTPL 804
Score = 105 bits (261), Expect = 2e-22
Identities = 78/236 (33%), Positives = 120/236 (50%), Gaps = 20/236 (8%)
Query: 18 LTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEH-YRVQTQQT 76
L +A LLLNR S + + Q G TPL IA+R G+ +VRLLL+ +++T+
Sbjct: 252 LNVAQLLLNRGAS-----VNFTPQNG---ITPLHIASRRGNVIMVRLLLDRGAQIETKTK 303
Query: 77 GTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDI 136
D T L CAA GH + ++L+ HGA + T +P+ A LD
Sbjct: 304 ----------DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 353
Query: 137 VKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAE 196
V+ L++ +A I T L +AA+ GH V + LL++ A PN++A G T LH A +
Sbjct: 354 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 413
Query: 197 AGHIDIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIE 251
H+ +++ L+K A+I V G+TPL VA+ +V+ LL S ++
Sbjct: 414 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 469
Score = 94.7 bits (234), Expect = 2e-19
Identities = 72/234 (30%), Positives = 115/234 (49%), Gaps = 19/234 (8%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
++ AA G LL N+++ V+ + TPL AAR GH +V+LLLE
Sbjct: 474 LHMAARAGHTEVAKYLLQNKAK---------VNAKAKDDQTPLHCAARIGHTNMVKLLLE 524
Query: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
+ T G T L AA GH E V L+ A+ T TPL
Sbjct: 525 NNANPNLATTA---------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 575
Query: 128 ACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCG 187
A G++ + + L+E +A+ + A K T L +A + + D+V+ LL + P++ A G
Sbjct: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 635
Query: 188 ATALHFAAEAGHIDIVKELIKW-RAAIVVNGHGMTPLKVAAESCKADVVELLLS 240
T LH AA+ +++ + L+++ +A + G+TPL +AA+ A++V LLLS
Sbjct: 636 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 689
Score = 94.7 bits (234), Expect = 2e-19
Identities = 63/192 (32%), Positives = 98/192 (51%), Gaps = 10/192 (5%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL IAA+ +V R LL++ ++ + G T L AA GH E+V LL
Sbjct: 637 TPLHIAAKQNQVEVARSLLQYGGSANAES---------VQGVTPLHLAAQEGHAEMVALL 687
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+S AN N + TPL +G + + L+++ + + T L +A++ G+
Sbjct: 688 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 747
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAA-IVVNGHGMTPLKVA 226
+V++LL+ +AD NAK G + LH AA+ GH DIV L+K A+ V+ G TPL +A
Sbjct: 748 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807
Query: 227 AESCKADVVELL 238
V ++L
Sbjct: 808 KRLGYISVTDVL 819
Score = 87.8 bits (216), Expect = 3e-17
Identities = 73/230 (31%), Positives = 109/230 (47%), Gaps = 13/230 (5%)
Query: 12 ASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRV 71
A+E LA L E+ + +L+ Y +G R L IAARN + +LL++
Sbjct: 173 ATEDGFTPLAVALQQGHENVVAHLINY-GTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 231
Query: 72 QTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFD 131
+ T G T L AA + V +LL++ GA+VN T TPL A
Sbjct: 232 PDVLSKT---------GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 282
Query: 132 GRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATAL 191
G + +V+ L++ A I K + T L AA GH + LL+ A AK G + +
Sbjct: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 342
Query: 192 HFAAEAGHIDIVKELIKWRAAI--VVNGHGMTPLKVAAESCKADVVELLL 239
H AA+ H+D V+ L+++ A I + H +TPL VAA V ++LL
Sbjct: 343 HMAAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLL 391
Score = 87.8 bits (216), Expect = 3e-17
Identities = 75/256 (29%), Positives = 110/256 (42%), Gaps = 34/256 (13%)
Query: 11 AASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE--- 67
AA EG V T+ ALL + G+ TPL +AA+ G +V LLLE
Sbjct: 543 AAREGHVETVLALLEKEASQACMTKKGF---------TPLHVAAKYGKVRVAELLLERDA 593
Query: 68 -------------HYRVQTQQTGTVRF--------DGYVIDGATALWCAAGAGHFEVVKL 106
H V V+ +G T L AA EV +
Sbjct: 594 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 653
Query: 107 LVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGH 166
L+ +G + N +V TPL A +G ++V L+ AN ++ NK T L + A +GH
Sbjct: 654 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 713
Query: 167 TDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGH-GMTPLKV 225
V L++ +A G T LH A+ G+I +VK L++ +A + G +PL
Sbjct: 714 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 773
Query: 226 AAESCKADVVELLLSH 241
AA+ D+V LLL +
Sbjct: 774 AAQQGHTDIVTLLLKN 789
Score = 87.0 bits (214), Expect = 5e-17
Identities = 72/232 (31%), Positives = 113/232 (48%), Gaps = 44/232 (18%)
Query: 50 LIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVS 109
L +A++ GH K+V LL H + + T G TAL AA AG EVV+ LV+
Sbjct: 82 LHLASKEGHVKMVVELL-HKEIILETTTK--------KGNTALHIAALAGQDEVVRELVN 132
Query: 110 HGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDV 169
+GANVN + TPL A + L++VK+L+EN AN ++A + T L +A +GH +V
Sbjct: 133 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 192
Query: 170 VRY-----------------------------LLEQRADPNAKAHCGATALHFAAEAGHI 200
V + LL+ +P+ + G T LH AA ++
Sbjct: 193 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 252
Query: 201 DIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIE 251
++ + L+ A++ +G+TPL +A+ +V LLL DR ++IE
Sbjct: 253 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL-----DRGAQIE 299
Score = 84.3 bits (207), Expect = 3e-16
Identities = 116/523 (22%), Positives = 210/523 (40%), Gaps = 78/523 (14%)
Query: 87 DGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNAN 146
D AT+ AA +G+ + + +G ++N L A +G + +V L+
Sbjct: 44 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 103
Query: 147 ISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKEL 206
+ K NT L IAA G +VVR L+ A+ NA++ G T L+ AA+ H+++VK L
Sbjct: 104 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 163
Query: 207 IKWRA-AIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRE 265
++ A V G TPL VA + +VV L+++ + R+ AL + +
Sbjct: 164 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG-TKGKVRLPALHIAARN------ 216
Query: 266 NYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRDALH 325
D +T A+L + ++L K P+H + Q L + +
Sbjct: 217 --DDTRT-----AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 269
Query: 326 MEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDL 385
G+ N+ + ++ RGA + E K L LH + ++
Sbjct: 270 QNGITPLHIASRRGNVIMVRLLLDRGA------QIETKTKDELTPLHCAARNGHVRISEI 323
Query: 386 LR------FAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDN 439
L A+ + + ++ + ++CV R+ DA++ +
Sbjct: 324 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV-------------RLLLQYDAEIDD---- 366
Query: 440 YECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTPVD 499
T +L + C K+ + + R GFT LH+A N
Sbjct: 367 -----ITLDHLTPLHVAAHCGHHRVAKV--LLDKGAKPNSRALNGFTPLHIACKKN---- 415
Query: 500 DFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISL 559
+ V +LLL GA ++AV G + LH ++ F+ I+ +L
Sbjct: 416 -----------HVRVMELLLKTGASIDAVTESGLTPLH--------VASFMGHLPIVKNL 456
Query: 560 VEAGAHTDMTNKQNKTPLDKST----TGVSEILLKTQMKMSLK 598
++ GA +++N + +TPL + T V++ LL+ + K++ K
Sbjct: 457 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 499
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 119 bits (299), Expect = 6e-27
Identities = 83/228 (36%), Positives = 116/228 (50%), Gaps = 18/228 (7%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL IA + H +V+ LLL+ TG D G T L A+ GH +VK L
Sbjct: 373 TPLHIACKKNHVRVMELLLK--------TGA-SIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ GA+ N + V TPL A G ++ KYL++N A ++ K D T L AA GHT
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAA-IVVNGHGMTPLKVA 226
++V+ LLE A+PN G T LH AA GH++ V L++ A+ + G TPL VA
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 227 AESCKADVVELLL---SHADCDRRSRIEALELLGASFANDRENYDIIK 271
A+ K V ELLL +H + ++ + L + A N DI+K
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHV-----AVHHNNLDIVK 586
Score = 108 bits (270), Expect = 1e-23
Identities = 133/558 (23%), Positives = 219/558 (39%), Gaps = 88/558 (15%)
Query: 48 TPLIIAARNGHAKVVRLLLEH----------------YRVQTQQTGTVRF--------DG 83
TPL AARNGH ++ +LL+H Q VR D
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 84 YVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVEN 143
+D T L AA GH V K+L+ GA N + TPL AC + +++ L++
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 144 NANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIV 203
A+I + T L +A++ GH +V+ LL++ A PN T LH AA AGH ++
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
Query: 204 KELIKWRAAIVVNG-HGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFAN 262
K L++ +A + TPL AA ++V+LLL + A L + +
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN---------NANPNLATTAGH 504
Query: 263 DRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRD 322
+ + + LA+LE+ + + K+ P+H + R + L +
Sbjct: 505 TPLHIAAREGHVETVLALLEK-EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 323 ALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLW--LHALHLRQKGNRN 380
A GL + +N+D+ ++ RG W LH+ K N+
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGG--------SPHSPAWNGYTPLHIAAKQNQ- 614
Query: 381 THKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDNY 440
+V ++ + A ++ V + E V + + + N
Sbjct: 615 --------VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK 666
Query: 441 ECNLYTFLYLVCISTKTQCSEEDQCKI-NKQIYNLIHLDPRTREGFTLLHLAVNSNTPVD 499
+ T L+LV ++E + + I + + +D TR G+T LH+A +
Sbjct: 667 --SGLTPLHLV--------AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH------ 710
Query: 500 DFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISL 559
+ N + K LL A+VNA G S LH Q +D +TL L
Sbjct: 711 ---------YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH--TDIVTL------L 753
Query: 560 VEAGAHTDMTNKQNKTPL 577
++ GA + + TPL
Sbjct: 754 LKNGASPNEVSSDGTTPL 771
Score = 105 bits (261), Expect = 2e-22
Identities = 78/236 (33%), Positives = 120/236 (50%), Gaps = 20/236 (8%)
Query: 18 LTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEH-YRVQTQQT 76
L +A LLLNR S + + Q G TPL IA+R G+ +VRLLL+ +++T+
Sbjct: 219 LNVAQLLLNRGAS-----VNFTPQNG---ITPLHIASRRGNVIMVRLLLDRGAQIETKTK 270
Query: 77 GTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDI 136
D T L CAA GH + ++L+ HGA + T +P+ A LD
Sbjct: 271 ----------DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 137 VKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAE 196
V+ L++ +A I T L +AA+ GH V + LL++ A PN++A G T LH A +
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 197 AGHIDIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIE 251
H+ +++ L+K A+I V G+TPL VA+ +V+ LL S ++
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
Score = 94.7 bits (234), Expect = 2e-19
Identities = 72/234 (30%), Positives = 115/234 (49%), Gaps = 19/234 (8%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
++ AA G LL N+++ V+ + TPL AAR GH +V+LLLE
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAK---------VNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
+ T G T L AA GH E V L+ A+ T TPL
Sbjct: 492 NNANPNLATTA---------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 128 ACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCG 187
A G++ + + L+E +A+ + A K T L +A + + D+V+ LL + P++ A G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 188 ATALHFAAEAGHIDIVKELIKW-RAAIVVNGHGMTPLKVAAESCKADVVELLLS 240
T LH AA+ +++ + L+++ +A + G+TPL +AA+ A++V LLLS
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Score = 94.7 bits (234), Expect = 2e-19
Identities = 63/192 (32%), Positives = 98/192 (51%), Gaps = 10/192 (5%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL IAA+ +V R LL++ ++ + G T L AA GH E+V LL
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES---------VQGVTPLHLAAQEGHAEMVALL 654
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+S AN N + TPL +G + + L+++ + + T L +A++ G+
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAA-IVVNGHGMTPLKVA 226
+V++LL+ +AD NAK G + LH AA+ GH DIV L+K A+ V+ G TPL +A
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Query: 227 AESCKADVVELL 238
V ++L
Sbjct: 775 KRLGYISVTDVL 786
Score = 87.8 bits (216), Expect = 3e-17
Identities = 73/230 (31%), Positives = 109/230 (47%), Gaps = 13/230 (5%)
Query: 12 ASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRV 71
A+E LA L E+ + +L+ Y +G R L IAARN + +LL++
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINY-GTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198
Query: 72 QTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFD 131
+ T G T L AA + V +LL++ GA+VN T TPL A
Sbjct: 199 PDVLSKT---------GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Query: 132 GRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATAL 191
G + +V+ L++ A I K + T L AA GH + LL+ A AK G + +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
Query: 192 HFAAEAGHIDIVKELIKWRAAI--VVNGHGMTPLKVAAESCKADVVELLL 239
H AA+ H+D V+ L+++ A I + H +TPL VAA V ++LL
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLL 358
Score = 87.8 bits (216), Expect = 3e-17
Identities = 75/256 (29%), Positives = 110/256 (42%), Gaps = 34/256 (13%)
Query: 11 AASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE--- 67
AA EG V T+ ALL + G+ TPL +AA+ G +V LLLE
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGF---------TPLHVAAKYGKVRVAELLLERDA 560
Query: 68 -------------HYRVQTQQTGTVRF--------DGYVIDGATALWCAAGAGHFEVVKL 106
H V V+ +G T L AA EV +
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Query: 107 LVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGH 166
L+ +G + N +V TPL A +G ++V L+ AN ++ NK T L + A +GH
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 167 TDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGH-GMTPLKV 225
V L++ +A G T LH A+ G+I +VK L++ +A + G +PL
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
Query: 226 AAESCKADVVELLLSH 241
AA+ D+V LLL +
Sbjct: 741 AAQQGHTDIVTLLLKN 756
Score = 87.0 bits (214), Expect = 5e-17
Identities = 72/232 (31%), Positives = 113/232 (48%), Gaps = 44/232 (18%)
Query: 50 LIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVS 109
L +A++ GH K+V LL H + + T G TAL AA AG EVV+ LV+
Sbjct: 49 LHLASKEGHVKMVVELL-HKEIILETTTK--------KGNTALHIAALAGQDEVVRELVN 99
Query: 110 HGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDV 169
+GANVN + TPL A + L++VK+L+EN AN ++A + T L +A +GH +V
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 159
Query: 170 VRY-----------------------------LLEQRADPNAKAHCGATALHFAAEAGHI 200
V + LL+ +P+ + G T LH AA ++
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 201 DIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIE 251
++ + L+ A++ +G+TPL +A+ +V LLL DR ++IE
Sbjct: 220 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL-----DRGAQIE 266
Score = 84.3 bits (207), Expect = 3e-16
Identities = 116/523 (22%), Positives = 210/523 (40%), Gaps = 78/523 (14%)
Query: 87 DGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNAN 146
D AT+ AA +G+ + + +G ++N L A +G + +V L+
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70
Query: 147 ISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKEL 206
+ K NT L IAA G +VVR L+ A+ NA++ G T L+ AA+ H+++VK L
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 207 IKWRA-AIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRE 265
++ A V G TPL VA + +VV L+++ + R+ AL + +
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG-TKGKVRLPALHIAARN------ 183
Query: 266 NYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRDALH 325
D +T A+L + ++L K P+H + Q L + +
Sbjct: 184 --DDTRT-----AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 326 MEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDL 385
G+ N+ + ++ RGA + E K L LH + ++
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGA------QIETKTKDELTPLHCAARNGHVRISEI 290
Query: 386 LR------FAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDN 439
L A+ + + ++ + ++CV R+ DA++ +
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV-------------RLLLQYDAEIDD---- 333
Query: 440 YECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTPVD 499
T +L + C K+ + + R GFT LH+A N
Sbjct: 334 -----ITLDHLTPLHVAAHCGHHRVAKV--LLDKGAKPNSRALNGFTPLHIACKKN---- 382
Query: 500 DFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISL 559
+ V +LLL GA ++AV G + LH ++ F+ I+ +L
Sbjct: 383 -----------HVRVMELLLKTGASIDAVTESGLTPLH--------VASFMGHLPIVKNL 423
Query: 560 VEAGAHTDMTNKQNKTPLDKST----TGVSEILLKTQMKMSLK 598
++ GA +++N + +TPL + T V++ LL+ + K++ K
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 119 bits (299), Expect = 6e-27
Identities = 83/228 (36%), Positives = 116/228 (50%), Gaps = 18/228 (7%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL IA + H +V+ LLL+ TG D G T L A+ GH +VK L
Sbjct: 373 TPLHIACKKNHVRVMELLLK--------TGA-SIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ GA+ N + V TPL A G ++ KYL++N A ++ K D T L AA GHT
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAA-IVVNGHGMTPLKVA 226
++V+ LLE A+PN G T LH AA GH++ V L++ A+ + G TPL VA
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 227 AESCKADVVELLL---SHADCDRRSRIEALELLGASFANDRENYDIIK 271
A+ K V ELLL +H + ++ + L + A N DI+K
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHV-----AVHHNNLDIVK 586
Score = 108 bits (270), Expect = 1e-23
Identities = 133/558 (23%), Positives = 219/558 (39%), Gaps = 88/558 (15%)
Query: 48 TPLIIAARNGHAKVVRLLLEH----------------YRVQTQQTGTVRF--------DG 83
TPL AARNGH ++ +LL+H Q VR D
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 84 YVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVEN 143
+D T L AA GH V K+L+ GA N + TPL AC + +++ L++
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 144 NANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIV 203
A+I + T L +A++ GH +V+ LL++ A PN T LH AA AGH ++
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
Query: 204 KELIKWRAAIVVNG-HGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFAN 262
K L++ +A + TPL AA ++V+LLL + A L + +
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN---------NANPNLATTAGH 504
Query: 263 DRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRD 322
+ + + LA+LE+ + + K+ P+H + R + L +
Sbjct: 505 TPLHIAAREGHVETVLALLEK-EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 323 ALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLW--LHALHLRQKGNRN 380
A GL + +N+D+ ++ RG W LH+ K N+
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGG--------SPHSPAWNGYTPLHIAAKQNQ- 614
Query: 381 THKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDNY 440
+V ++ + A ++ V + E V + + + N
Sbjct: 615 --------VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK 666
Query: 441 ECNLYTFLYLVCISTKTQCSEEDQCKI-NKQIYNLIHLDPRTREGFTLLHLAVNSNTPVD 499
+ T L+LV ++E + + I + + +D TR G+T LH+A +
Sbjct: 667 --SGLTPLHLV--------AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH------ 710
Query: 500 DFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISL 559
+ N + K LL A+VNA G S LH Q +D +TL L
Sbjct: 711 ---------YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH--TDIVTL------L 753
Query: 560 VEAGAHTDMTNKQNKTPL 577
++ GA + + TPL
Sbjct: 754 LKNGASPNEVSSDGTTPL 771
Score = 105 bits (261), Expect = 2e-22
Identities = 78/236 (33%), Positives = 120/236 (50%), Gaps = 20/236 (8%)
Query: 18 LTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEH-YRVQTQQT 76
L +A LLLNR S + + Q G TPL IA+R G+ +VRLLL+ +++T+
Sbjct: 219 LNVAQLLLNRGAS-----VNFTPQNG---ITPLHIASRRGNVIMVRLLLDRGAQIETKTK 270
Query: 77 GTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDI 136
D T L CAA GH + ++L+ HGA + T +P+ A LD
Sbjct: 271 ----------DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 137 VKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAE 196
V+ L++ +A I T L +AA+ GH V + LL++ A PN++A G T LH A +
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 197 AGHIDIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIE 251
H+ +++ L+K A+I V G+TPL VA+ +V+ LL S ++
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
Score = 94.7 bits (234), Expect = 2e-19
Identities = 72/234 (30%), Positives = 115/234 (49%), Gaps = 19/234 (8%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
++ AA G LL N+++ V+ + TPL AAR GH +V+LLLE
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAK---------VNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
+ T G T L AA GH E V L+ A+ T TPL
Sbjct: 492 NNANPNLATTA---------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 128 ACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCG 187
A G++ + + L+E +A+ + A K T L +A + + D+V+ LL + P++ A G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 188 ATALHFAAEAGHIDIVKELIKW-RAAIVVNGHGMTPLKVAAESCKADVVELLLS 240
T LH AA+ +++ + L+++ +A + G+TPL +AA+ A++V LLLS
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Score = 94.7 bits (234), Expect = 2e-19
Identities = 63/192 (32%), Positives = 98/192 (51%), Gaps = 10/192 (5%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL IAA+ +V R LL++ ++ + G T L AA GH E+V LL
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES---------VQGVTPLHLAAQEGHAEMVALL 654
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+S AN N + TPL +G + + L+++ + + T L +A++ G+
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAA-IVVNGHGMTPLKVA 226
+V++LL+ +AD NAK G + LH AA+ GH DIV L+K A+ V+ G TPL +A
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Query: 227 AESCKADVVELL 238
V ++L
Sbjct: 775 KRLGYISVTDVL 786
Score = 87.8 bits (216), Expect = 3e-17
Identities = 73/230 (31%), Positives = 109/230 (47%), Gaps = 13/230 (5%)
Query: 12 ASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRV 71
A+E LA L E+ + +L+ Y +G R L IAARN + +LL++
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINY-GTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198
Query: 72 QTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFD 131
+ T G T L AA + V +LL++ GA+VN T TPL A
Sbjct: 199 PDVLSKT---------GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Query: 132 GRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATAL 191
G + +V+ L++ A I K + T L AA GH + LL+ A AK G + +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
Query: 192 HFAAEAGHIDIVKELIKWRAAI--VVNGHGMTPLKVAAESCKADVVELLL 239
H AA+ H+D V+ L+++ A I + H +TPL VAA V ++LL
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLL 358
Score = 87.8 bits (216), Expect = 3e-17
Identities = 75/256 (29%), Positives = 110/256 (42%), Gaps = 34/256 (13%)
Query: 11 AASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE--- 67
AA EG V T+ ALL + G+ TPL +AA+ G +V LLLE
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGF---------TPLHVAAKYGKVRVAELLLERDA 560
Query: 68 -------------HYRVQTQQTGTVRF--------DGYVIDGATALWCAAGAGHFEVVKL 106
H V V+ +G T L AA EV +
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Query: 107 LVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGH 166
L+ +G + N +V TPL A +G ++V L+ AN ++ NK T L + A +GH
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 167 TDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGH-GMTPLKV 225
V L++ +A G T LH A+ G+I +VK L++ +A + G +PL
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
Query: 226 AAESCKADVVELLLSH 241
AA+ D+V LLL +
Sbjct: 741 AAQQGHTDIVTLLLKN 756
Score = 87.0 bits (214), Expect = 5e-17
Identities = 72/232 (31%), Positives = 113/232 (48%), Gaps = 44/232 (18%)
Query: 50 LIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVS 109
L +A++ GH K+V LL H + + T G TAL AA AG EVV+ LV+
Sbjct: 49 LHLASKEGHVKMVVELL-HKEIILETTTK--------KGNTALHIAALAGQDEVVRELVN 99
Query: 110 HGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDV 169
+GANVN + TPL A + L++VK+L+EN AN ++A + T L +A +GH +V
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 159
Query: 170 VRY-----------------------------LLEQRADPNAKAHCGATALHFAAEAGHI 200
V + LL+ +P+ + G T LH AA ++
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 201 DIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIE 251
++ + L+ A++ +G+TPL +A+ +V LLL DR ++IE
Sbjct: 220 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL-----DRGAQIE 266
Score = 84.3 bits (207), Expect = 3e-16
Identities = 116/523 (22%), Positives = 210/523 (40%), Gaps = 78/523 (14%)
Query: 87 DGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNAN 146
D AT+ AA +G+ + + +G ++N L A +G + +V L+
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70
Query: 147 ISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKEL 206
+ K NT L IAA G +VVR L+ A+ NA++ G T L+ AA+ H+++VK L
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 207 IKWRA-AIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRE 265
++ A V G TPL VA + +VV L+++ + R+ AL + +
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG-TKGKVRLPALHIAARN------ 183
Query: 266 NYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRDALH 325
D +T A+L + ++L K P+H + Q L + +
Sbjct: 184 --DDTRT-----AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 326 MEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDL 385
G+ N+ + ++ RGA + E K L LH + ++
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGA------QIETKTKDELTPLHCAARNGHVRISEI 290
Query: 386 LR------FAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDN 439
L A+ + + ++ + ++CV R+ DA++ +
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV-------------RLLLQYDAEIDD---- 333
Query: 440 YECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTPVD 499
T +L + C K+ + + R GFT LH+A N
Sbjct: 334 -----ITLDHLTPLHVAAHCGHHRVAKV--LLDKGAKPNSRALNGFTPLHIACKKN---- 382
Query: 500 DFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISL 559
+ V +LLL GA ++AV G + LH ++ F+ I+ +L
Sbjct: 383 -----------HVRVMELLLKTGASIDAVTESGLTPLH--------VASFMGHLPIVKNL 423
Query: 560 VEAGAHTDMTNKQNKTPLDKST----TGVSEILLKTQMKMSLK 598
++ GA +++N + +TPL + T V++ LL+ + K++ K
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 119 bits (299), Expect = 6e-27
Identities = 83/228 (36%), Positives = 116/228 (50%), Gaps = 18/228 (7%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL IA + H +V+ LLL+ TG D G T L A+ GH +VK L
Sbjct: 373 TPLHIACKKNHVRVMELLLK--------TGA-SIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ GA+ N + V TPL A G ++ KYL++N A ++ K D T L AA GHT
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAA-IVVNGHGMTPLKVA 226
++V+ LLE A+PN G T LH AA GH++ V L++ A+ + G TPL VA
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 227 AESCKADVVELLL---SHADCDRRSRIEALELLGASFANDRENYDIIK 271
A+ K V ELLL +H + ++ + L + A N DI+K
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHV-----AVHHNNLDIVK 586
Score = 108 bits (270), Expect = 1e-23
Identities = 133/558 (23%), Positives = 219/558 (39%), Gaps = 88/558 (15%)
Query: 48 TPLIIAARNGHAKVVRLLLEH----------------YRVQTQQTGTVRF--------DG 83
TPL AARNGH ++ +LL+H Q VR D
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 84 YVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVEN 143
+D T L AA GH V K+L+ GA N + TPL AC + +++ L++
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 144 NANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIV 203
A+I + T L +A++ GH +V+ LL++ A PN T LH AA AGH ++
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
Query: 204 KELIKWRAAIVVNG-HGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFAN 262
K L++ +A + TPL AA ++V+LLL + A L + +
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN---------NANPNLATTAGH 504
Query: 263 DRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRD 322
+ + + LA+LE+ + + K+ P+H + R + L +
Sbjct: 505 TPLHIAAREGHVETVLALLEK-EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 323 ALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLW--LHALHLRQKGNRN 380
A GL + +N+D+ ++ RG W LH+ K N+
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGG--------SPHSPAWNGYTPLHIAAKQNQ- 614
Query: 381 THKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDNY 440
+V ++ + A ++ V + E V + + + N
Sbjct: 615 --------VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK 666
Query: 441 ECNLYTFLYLVCISTKTQCSEEDQCKI-NKQIYNLIHLDPRTREGFTLLHLAVNSNTPVD 499
+ T L+LV ++E + + I + + +D TR G+T LH+A +
Sbjct: 667 --SGLTPLHLV--------AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH------ 710
Query: 500 DFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISL 559
+ N + K LL A+VNA G S LH Q +D +TL L
Sbjct: 711 ---------YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH--TDIVTL------L 753
Query: 560 VEAGAHTDMTNKQNKTPL 577
++ GA + + TPL
Sbjct: 754 LKNGASPNEVSSDGTTPL 771
Score = 105 bits (261), Expect = 2e-22
Identities = 78/236 (33%), Positives = 120/236 (50%), Gaps = 20/236 (8%)
Query: 18 LTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEH-YRVQTQQT 76
L +A LLLNR S + + Q G TPL IA+R G+ +VRLLL+ +++T+
Sbjct: 219 LNVAQLLLNRGAS-----VNFTPQNG---ITPLHIASRRGNVIMVRLLLDRGAQIETKTK 270
Query: 77 GTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDI 136
D T L CAA GH + ++L+ HGA + T +P+ A LD
Sbjct: 271 ----------DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 137 VKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAE 196
V+ L++ +A I T L +AA+ GH V + LL++ A PN++A G T LH A +
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 197 AGHIDIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIE 251
H+ +++ L+K A+I V G+TPL VA+ +V+ LL S ++
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
Score = 94.7 bits (234), Expect = 2e-19
Identities = 72/234 (30%), Positives = 115/234 (49%), Gaps = 19/234 (8%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
++ AA G LL N+++ V+ + TPL AAR GH +V+LLLE
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAK---------VNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
+ T G T L AA GH E V L+ A+ T TPL
Sbjct: 492 NNANPNLATTA---------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 128 ACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCG 187
A G++ + + L+E +A+ + A K T L +A + + D+V+ LL + P++ A G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 188 ATALHFAAEAGHIDIVKELIKW-RAAIVVNGHGMTPLKVAAESCKADVVELLLS 240
T LH AA+ +++ + L+++ +A + G+TPL +AA+ A++V LLLS
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Score = 94.7 bits (234), Expect = 2e-19
Identities = 63/192 (32%), Positives = 98/192 (51%), Gaps = 10/192 (5%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL IAA+ +V R LL++ ++ + G T L AA GH E+V LL
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES---------VQGVTPLHLAAQEGHAEMVALL 654
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+S AN N + TPL +G + + L+++ + + T L +A++ G+
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAA-IVVNGHGMTPLKVA 226
+V++LL+ +AD NAK G + LH AA+ GH DIV L+K A+ V+ G TPL +A
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Query: 227 AESCKADVVELL 238
V ++L
Sbjct: 775 KRLGYISVTDVL 786
Score = 87.8 bits (216), Expect = 3e-17
Identities = 73/230 (31%), Positives = 109/230 (47%), Gaps = 13/230 (5%)
Query: 12 ASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRV 71
A+E LA L E+ + +L+ Y +G R L IAARN + +LL++
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINY-GTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198
Query: 72 QTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFD 131
+ T G T L AA + V +LL++ GA+VN T TPL A
Sbjct: 199 PDVLSKT---------GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Query: 132 GRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATAL 191
G + +V+ L++ A I K + T L AA GH + LL+ A AK G + +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
Query: 192 HFAAEAGHIDIVKELIKWRAAI--VVNGHGMTPLKVAAESCKADVVELLL 239
H AA+ H+D V+ L+++ A I + H +TPL VAA V ++LL
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLL 358
Score = 87.8 bits (216), Expect = 3e-17
Identities = 75/256 (29%), Positives = 110/256 (42%), Gaps = 34/256 (13%)
Query: 11 AASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE--- 67
AA EG V T+ ALL + G+ TPL +AA+ G +V LLLE
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGF---------TPLHVAAKYGKVRVAELLLERDA 560
Query: 68 -------------HYRVQTQQTGTVRF--------DGYVIDGATALWCAAGAGHFEVVKL 106
H V V+ +G T L AA EV +
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Query: 107 LVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGH 166
L+ +G + N +V TPL A +G ++V L+ AN ++ NK T L + A +GH
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 167 TDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGH-GMTPLKV 225
V L++ +A G T LH A+ G+I +VK L++ +A + G +PL
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
Query: 226 AAESCKADVVELLLSH 241
AA+ D+V LLL +
Sbjct: 741 AAQQGHTDIVTLLLKN 756
Score = 87.0 bits (214), Expect = 5e-17
Identities = 72/232 (31%), Positives = 113/232 (48%), Gaps = 44/232 (18%)
Query: 50 LIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVS 109
L +A++ GH K+V LL H + + T G TAL AA AG EVV+ LV+
Sbjct: 49 LHLASKEGHVKMVVELL-HKEIILETTTK--------KGNTALHIAALAGQDEVVRELVN 99
Query: 110 HGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDV 169
+GANVN + TPL A + L++VK+L+EN AN ++A + T L +A +GH +V
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 159
Query: 170 VRY-----------------------------LLEQRADPNAKAHCGATALHFAAEAGHI 200
V + LL+ +P+ + G T LH AA ++
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 201 DIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIE 251
++ + L+ A++ +G+TPL +A+ +V LLL DR ++IE
Sbjct: 220 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL-----DRGAQIE 266
Score = 84.3 bits (207), Expect = 3e-16
Identities = 116/523 (22%), Positives = 210/523 (40%), Gaps = 78/523 (14%)
Query: 87 DGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNAN 146
D AT+ AA +G+ + + +G ++N L A +G + +V L+
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70
Query: 147 ISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKEL 206
+ K NT L IAA G +VVR L+ A+ NA++ G T L+ AA+ H+++VK L
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 207 IKWRA-AIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRE 265
++ A V G TPL VA + +VV L+++ + R+ AL + +
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG-TKGKVRLPALHIAARN------ 183
Query: 266 NYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRDALH 325
D +T A+L + ++L K P+H + Q L + +
Sbjct: 184 --DDTRT-----AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 326 MEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDL 385
G+ N+ + ++ RGA + E K L LH + ++
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGA------QIETKTKDELTPLHCAARNGHVRISEI 290
Query: 386 LR------FAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDN 439
L A+ + + ++ + ++CV R+ DA++ +
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV-------------RLLLQYDAEIDD---- 333
Query: 440 YECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTPVD 499
T +L + C K+ + + R GFT LH+A N
Sbjct: 334 -----ITLDHLTPLHVAAHCGHHRVAKV--LLDKGAKPNSRALNGFTPLHIACKKN---- 382
Query: 500 DFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISL 559
+ V +LLL GA ++AV G + LH ++ F+ I+ +L
Sbjct: 383 -----------HVRVMELLLKTGASIDAVTESGLTPLH--------VASFMGHLPIVKNL 423
Query: 560 VEAGAHTDMTNKQNKTPLDKST----TGVSEILLKTQMKMSLK 598
++ GA +++N + +TPL + T V++ LL+ + K++ K
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 119 bits (299), Expect = 6e-27
Identities = 83/228 (36%), Positives = 116/228 (50%), Gaps = 18/228 (7%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL IA + H +V+ LLL+ TG D G T L A+ GH +VK L
Sbjct: 373 TPLHIACKKNHVRVMELLLK--------TGA-SIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ GA+ N + V TPL A G ++ KYL++N A ++ K D T L AA GHT
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAA-IVVNGHGMTPLKVA 226
++V+ LLE A+PN G T LH AA GH++ V L++ A+ + G TPL VA
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Query: 227 AESCKADVVELLL---SHADCDRRSRIEALELLGASFANDRENYDIIK 271
A+ K V ELLL +H + ++ + L + A N DI+K
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHV-----AVHHNNLDIVK 586
Score = 108 bits (270), Expect = 1e-23
Identities = 133/558 (23%), Positives = 219/558 (39%), Gaps = 88/558 (15%)
Query: 48 TPLIIAARNGHAKVVRLLLEH----------------YRVQTQQTGTVRF--------DG 83
TPL AARNGH ++ +LL+H Q VR D
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 84 YVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVEN 143
+D T L AA GH V K+L+ GA N + TPL AC + +++ L++
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 144 NANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIV 203
A+I + T L +A++ GH +V+ LL++ A PN T LH AA AGH ++
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
Query: 204 KELIKWRAAIVVNG-HGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFAN 262
K L++ +A + TPL AA ++V+LLL + A L + +
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN---------NANPNLATTAGH 504
Query: 263 DRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRD 322
+ + + LA+LE+ + + K+ P+H + R + L +
Sbjct: 505 TPLHIAAREGHVETVLALLEK-EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 323 ALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLW--LHALHLRQKGNRN 380
A GL + +N+D+ ++ RG W LH+ K N+
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGG--------SPHSPAWNGYTPLHIAAKQNQ- 614
Query: 381 THKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDNY 440
+V ++ + A ++ V + E V + + + N
Sbjct: 615 --------VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK 666
Query: 441 ECNLYTFLYLVCISTKTQCSEEDQCKI-NKQIYNLIHLDPRTREGFTLLHLAVNSNTPVD 499
+ T L+LV ++E + + I + + +D TR G+T LH+A +
Sbjct: 667 --SGLTPLHLV--------AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH------ 710
Query: 500 DFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISL 559
+ N + K LL A+VNA G S LH Q +D +TL L
Sbjct: 711 ---------YGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH--TDIVTL------L 753
Query: 560 VEAGAHTDMTNKQNKTPL 577
++ GA + + TPL
Sbjct: 754 LKNGASPNEVSSDGTTPL 771
Score = 105 bits (261), Expect = 2e-22
Identities = 78/236 (33%), Positives = 120/236 (50%), Gaps = 20/236 (8%)
Query: 18 LTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEH-YRVQTQQT 76
L +A LLLNR S + + Q G TPL IA+R G+ +VRLLL+ +++T+
Sbjct: 219 LNVAQLLLNRGAS-----VNFTPQNG---ITPLHIASRRGNVIMVRLLLDRGAQIETKTK 270
Query: 77 GTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDI 136
D T L CAA GH + ++L+ HGA + T +P+ A LD
Sbjct: 271 ----------DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 137 VKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAE 196
V+ L++ +A I T L +AA+ GH V + LL++ A PN++A G T LH A +
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 197 AGHIDIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIE 251
H+ +++ L+K A+I V G+TPL VA+ +V+ LL S ++
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
Score = 94.7 bits (234), Expect = 2e-19
Identities = 72/234 (30%), Positives = 115/234 (49%), Gaps = 19/234 (8%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
++ AA G LL N+++ V+ + TPL AAR GH +V+LLLE
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAK---------VNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
+ T G T L AA GH E V L+ A+ T TPL
Sbjct: 492 NNANPNLATTA---------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 128 ACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCG 187
A G++ + + L+E +A+ + A K T L +A + + D+V+ LL + P++ A G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 188 ATALHFAAEAGHIDIVKELIKW-RAAIVVNGHGMTPLKVAAESCKADVVELLLS 240
T LH AA+ +++ + L+++ +A + G+TPL +AA+ A++V LLLS
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Score = 94.7 bits (234), Expect = 2e-19
Identities = 63/192 (32%), Positives = 98/192 (51%), Gaps = 10/192 (5%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL IAA+ +V R LL++ ++ + G T L AA GH E+V LL
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES---------VQGVTPLHLAAQEGHAEMVALL 654
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+S AN N + TPL +G + + L+++ + + T L +A++ G+
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAA-IVVNGHGMTPLKVA 226
+V++LL+ +AD NAK G + LH AA+ GH DIV L+K A+ V+ G TPL +A
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Query: 227 AESCKADVVELL 238
V ++L
Sbjct: 775 KRLGYISVTDVL 786
Score = 87.8 bits (216), Expect = 3e-17
Identities = 73/230 (31%), Positives = 109/230 (47%), Gaps = 13/230 (5%)
Query: 12 ASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRV 71
A+E LA L E+ + +L+ Y +G R L IAARN + +LL++
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINY-GTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198
Query: 72 QTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFD 131
+ T G T L AA + V +LL++ GA+VN T TPL A
Sbjct: 199 PDVLSKT---------GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Query: 132 GRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATAL 191
G + +V+ L++ A I K + T L AA GH + LL+ A AK G + +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
Query: 192 HFAAEAGHIDIVKELIKWRAAI--VVNGHGMTPLKVAAESCKADVVELLL 239
H AA+ H+D V+ L+++ A I + H +TPL VAA V ++LL
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLL 358
Score = 87.8 bits (216), Expect = 3e-17
Identities = 75/256 (29%), Positives = 110/256 (42%), Gaps = 34/256 (13%)
Query: 11 AASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE--- 67
AA EG V T+ ALL + G+ TPL +AA+ G +V LLLE
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGF---------TPLHVAAKYGKVRVAELLLERDA 560
Query: 68 -------------HYRVQTQQTGTVRF--------DGYVIDGATALWCAAGAGHFEVVKL 106
H V V+ +G T L AA EV +
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Query: 107 LVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGH 166
L+ +G + N +V TPL A +G ++V L+ AN ++ NK T L + A +GH
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 167 TDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGH-GMTPLKV 225
V L++ +A G T LH A+ G+I +VK L++ +A + G +PL
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
Query: 226 AAESCKADVVELLLSH 241
AA+ D+V LLL +
Sbjct: 741 AAQQGHTDIVTLLLKN 756
Score = 87.0 bits (214), Expect = 5e-17
Identities = 72/232 (31%), Positives = 113/232 (48%), Gaps = 44/232 (18%)
Query: 50 LIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVS 109
L +A++ GH K+V LL H + + T G TAL AA AG EVV+ LV+
Sbjct: 49 LHLASKEGHVKMVVELL-HKEIILETTTK--------KGNTALHIAALAGQDEVVRELVN 99
Query: 110 HGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDV 169
+GANVN + TPL A + L++VK+L+EN AN ++A + T L +A +GH +V
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 159
Query: 170 VRY-----------------------------LLEQRADPNAKAHCGATALHFAAEAGHI 200
V + LL+ +P+ + G T LH AA ++
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 201 DIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIE 251
++ + L+ A++ +G+TPL +A+ +V LLL DR ++IE
Sbjct: 220 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL-----DRGAQIE 266
Score = 84.3 bits (207), Expect = 3e-16
Identities = 116/523 (22%), Positives = 210/523 (40%), Gaps = 78/523 (14%)
Query: 87 DGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNAN 146
D AT+ AA +G+ + + +G ++N L A +G + +V L+
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70
Query: 147 ISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKEL 206
+ K NT L IAA G +VVR L+ A+ NA++ G T L+ AA+ H+++VK L
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 207 IKWRA-AIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRE 265
++ A V G TPL VA + +VV L+++ + R+ AL + +
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG-TKGKVRLPALHIAARN------ 183
Query: 266 NYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRDALH 325
D +T A+L + ++L K P+H + Q L + +
Sbjct: 184 --DDTRT-----AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 326 MEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDL 385
G+ N+ + ++ RGA + E K L LH + ++
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGA------QIETKTKDELTPLHCAARNGHVRISEI 290
Query: 386 LR------FAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDN 439
L A+ + + ++ + ++CV R+ DA++ +
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV-------------RLLLQYDAEIDD---- 333
Query: 440 YECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTPVD 499
T +L + C K+ + + R GFT LH+A N
Sbjct: 334 -----ITLDHLTPLHVAAHCGHHRVAKV--LLDKGAKPNSRALNGFTPLHIACKKN---- 382
Query: 500 DFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISL 559
+ V +LLL GA ++AV G + LH ++ F+ I+ +L
Sbjct: 383 -----------HVRVMELLLKTGASIDAVTESGLTPLH--------VASFMGHLPIVKNL 423
Query: 560 VEAGAHTDMTNKQNKTPLDKST----TGVSEILLKTQMKMSLK 598
++ GA +++N + +TPL + T V++ LL+ + K++ K
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 118 bits (295), Expect = 2e-26
Identities = 124/506 (24%), Positives = 199/506 (39%), Gaps = 81/506 (16%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
+PL +A + H V+LLL+H V D D TAL AA GH++V K+L
Sbjct: 336 SPLHMATQGDHLNCVQLLLQH---------NVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ AN N + TPL AC R+ +++ L+++ A+I + T + +AA+ GH
Sbjct: 387 LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHV 446
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNG-HGMTPLKVA 226
++V L+ A PN G TALH AA +G ++V+ L++ A + TPL ++
Sbjct: 447 NIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHIS 506
Query: 227 AESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQD 286
A KAD+V+ LL + L S RE ++ + + + A L
Sbjct: 507 ARLGKADIVQQLLQQGASPNAATTSGYTPLHLS---AREGHEDVAAFLLDHGASL----- 558
Query: 287 GDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHP 346
+I K+ P+H + L DA GL DN V+
Sbjct: 559 --SITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALL 616
Query: 347 IIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNETVKAPD 406
++ +GA K LH+ K N
Sbjct: 617 LLDQGA------SPHAAAKNGYTPLHIAAKKN---------------------------- 642
Query: 407 IECVLRCSVLEIEQSMNRVKNISDADVHNAMDNYECNLYTFLY----LVCISTKT----- 457
+ + ++LE N V A VH A ++ + L V +S K+
Sbjct: 643 -QMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPL 701
Query: 458 -QCSEEDQCKINKQIYNL-IHLDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVT 515
++ED+ + + + N H+D +T+ G+T LH+ C + N +
Sbjct: 702 HLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVG---------------CHYGNIKIV 746
Query: 516 KLLLDCGAEVNAVDNEGNSALHIIVQ 541
LL A+VNA G + LH Q
Sbjct: 747 NFLLQHSAKVNAKTKNGYTPLHQAAQ 772
Score = 108 bits (271), Expect = 1e-23
Identities = 78/244 (31%), Positives = 126/244 (51%), Gaps = 21/244 (8%)
Query: 1 MEGLAGY--VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGH 58
+E +G+ ++ AA G + +A LLLNR+ + V TPL +A++ G+
Sbjct: 230 VESKSGFTPLHIAAHYGNI-NVATLLLNRAAA--------VDFTARNDITPLHVASKRGN 280
Query: 59 AKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTT 118
A +V+LLL+ + D DG T L C A +GH +VV++L+ A + T
Sbjct: 281 ANMVKLLLDR---------GAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKT 331
Query: 119 VTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRA 178
+PL A L+ V+ L+++N + T L +AA+ GH V + LL+++A
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA 391
Query: 179 DPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVEL 237
+PNAKA G T LH A + I +++ L+K A+I V G+TP+ VAA ++V
Sbjct: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQ 451
Query: 238 LLSH 241
L+ H
Sbjct: 452 LMHH 455
Score = 99.4 bits (246), Expect = 9e-21
Identities = 78/239 (32%), Positives = 114/239 (47%), Gaps = 13/239 (5%)
Query: 32 IRYLL---GYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDG 88
+RYL+ V + TPL I+AR G A +V+ LL+ Q GY
Sbjct: 482 VRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ----QGASPNAATTSGY---- 533
Query: 89 ATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANIS 148
T L +A GH +V L+ HGA+++ TT TPL A G+L++ L++ +A+
Sbjct: 534 -TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD 592
Query: 149 IANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIK 208
A K T L +AA+ + V LL+Q A P+A A G T LH AA+ +DI L++
Sbjct: 593 AAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLE 652
Query: 209 WRA-AIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDREN 266
+ A A V G+ + +AA+ D+V LLL S L L + DR N
Sbjct: 653 YGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVN 711
Score = 90.1 bits (222), Expect = 5e-18
Identities = 121/513 (23%), Positives = 207/513 (40%), Gaps = 97/513 (18%)
Query: 95 AAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYD 154
AA AGH E + +G ++N L A +G +++V L++ AN+ A K
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 155 NTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAA-I 213
NT L IA+ G +VV+ L+ A+ NA++ G T L+ AA+ H+++VK L+ A+
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167
Query: 214 VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDIIKTY 273
+ G TPL VA + VV LLL + D + R+ AL + A+ +D +
Sbjct: 168 LATEDGFTPLAVALQQGHDQVVSLLLEN-DTKGKVRLPALHI--AARKDDTK-------- 216
Query: 274 HYLYLAMLERFQDGDNILEKEVLPPIHA---YGNRTEC-----RNPQELESIRQDRDALH 325
A+L + + ++ K P+H YGN R + R D LH
Sbjct: 217 ---AAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLH 273
Query: 326 MEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDL 385
+ N ++ ++ RGA + + + L LH G R+ H+ +
Sbjct: 274 VAS--------KRGNANMVKLLLDRGA------KIDAKTRDGLTPLHC---GARSGHEQV 316
Query: 386 L-----RFAQVFSQ----MIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNA 436
+ R A + S+ + L+ + + CV + N+ DV N
Sbjct: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCV----------QLLLQHNVPVDDVTND 366
Query: 437 MDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNT 496
YL + C K+ + + + + GFT LH+A N
Sbjct: 367 ------------YLTALHVAAHCGHYKVAKV--LLDKKANPNAKALNGFTPLHIACKKN- 411
Query: 497 PVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSII 556
V +LLL GA + AV G + +H ++ F+ +I+
Sbjct: 412 --------------RIKVMELLLKHGASIQAVTESGLTPIH--------VAAFMGHVNIV 449
Query: 557 ISLVEAGAHTDMTNKQNKTPLDKST-TGVSEIL 588
L+ GA + TN + +T L + +G +E++
Sbjct: 450 SQLMHHGASPNTTNVRGETALHMAARSGQAEVV 482
Score = 86.7 bits (213), Expect = 6e-17
Identities = 68/235 (28%), Positives = 112/235 (47%), Gaps = 23/235 (9%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
+Y AA E + + LL N + + G+ TPL +A + GH +VV LLLE
Sbjct: 144 LYMAAQENHLEVVKFLLDNGASQSLATEDGF---------TPLAVALQQGHDQVVSLLLE 194
Query: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
+ G VR AL AA + LL+ + N + + + TPL
Sbjct: 195 N-----DTKGKVRLP--------ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHI 241
Query: 128 ACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCG 187
A G +++ L+ A + + D T L +A+ +G+ ++V+ LL++ A +AK G
Sbjct: 242 AAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDG 301
Query: 188 ATALHFAAEAGHIDIVKELIKWRAAIV-VNGHGMTPLKVAAESCKADVVELLLSH 241
T LH A +GH +V+ L+ A I+ +G++PL +A + + V+LLL H
Sbjct: 302 LTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQH 356
Score = 85.9 bits (211), Expect = 1e-16
Identities = 71/235 (30%), Positives = 109/235 (46%), Gaps = 19/235 (8%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
++ AA GK L +A LLL +S S G TPL +AA + KV LLL+
Sbjct: 569 LHVAAKYGK-LEVANLLLQKSASP--------DAAGKSGLTPLHVAAHYDNQKVALLLLD 619
Query: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
Q +GY T L AA ++ L+ +GA+ N T +
Sbjct: 620 ----QGASPHAAAKNGY-----TPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHL 670
Query: 128 ACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCG 187
A +G +D+V L+ NAN++++NK T L +AA + +V L+ Q A +A+ G
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 730
Query: 188 ATALHFAAEAGHIDIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLLSH 241
T LH G+I IV L++ A + +G TPL AA+ ++ +LL +
Sbjct: 731 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQN 785
Score = 85.9 bits (211), Expect = 1e-16
Identities = 61/194 (31%), Positives = 93/194 (47%), Gaps = 14/194 (7%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL IAA+ + LLE+ T G ++ AA GH ++V LL
Sbjct: 633 TPLHIAAKKNQMDIATTLLEYGADANAVTR---------QGIASVHLAAQEGHVDMVSLL 683
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ ANVN + + TPL A + R+++ + LV A++ K T L + + G+
Sbjct: 684 LGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNI 743
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAA---IVVNGHGMTPLK 224
+V +LL+ A NAK G T LH AA+ GH I+ L++ A+ + VNG+ T L
Sbjct: 744 KIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGN--TALG 801
Query: 225 VAAESCKADVVELL 238
+A VV+ L
Sbjct: 802 IARRLGYISVVDTL 815
Score = 82.8 bits (203), Expect = 9e-16
Identities = 75/256 (29%), Positives = 106/256 (41%), Gaps = 72/256 (28%)
Query: 50 LIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVS 109
L +A++ GH +VV LL+ D G TAL A+ AG EVVK+LV+
Sbjct: 78 LHLASKEGHVEVVSELLQR---------EANVDAATKKGNTALHIASLAGQAEVVKVLVT 128
Query: 110 HGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDV 169
+GANVN + TPL A + L++VK+L++N A+ S+A + T L +A +GH V
Sbjct: 129 NGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQV 188
Query: 170 VRYLLEQ---------------------------RADPNA--KAHCGATALHFAAEAGHI 200
V LLE + D NA ++ G T LH AA G+I
Sbjct: 189 VSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNI 248
Query: 201 DIVKELIKWRAAIVVNGH----------------------------------GMTPLKVA 226
++ L+ AA+ G+TPL
Sbjct: 249 NVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG 308
Query: 227 AESCKADVVELLLSHA 242
A S VVE+LL A
Sbjct: 309 ARSGHEQVVEMLLDRA 324
Score = 77.8 bits (190), Expect = 3e-14
Identities = 65/218 (29%), Positives = 99/218 (45%), Gaps = 38/218 (17%)
Query: 87 DGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNAN 146
+G AL A+ GH EVV L+ ANV+ T +T L A G+ ++VK LV N AN
Sbjct: 73 NGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGAN 132
Query: 147 ISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKEL 206
++ ++ T L +AA + H +VV++LL+ A + G T L A + GH +V L
Sbjct: 133 VNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192
Query: 207 I----------------------KWRAAIVVNGH--------GMTPLKVAAESCKADVVE 236
+ K A ++ N + G TPL +AA +V
Sbjct: 193 LENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVAT 252
Query: 237 LLLSHA---DCDRRSRIEALELLGASFANDRENYDIIK 271
LLL+ A D R+ I L + A+ R N +++K
Sbjct: 253 LLLNRAAAVDFTARNDITPLHV-----ASKRGNANMVK 285
Score = 35.0 bits (79), Expect = 0.21
Identities = 29/112 (25%), Positives = 52/112 (46%), Gaps = 27/112 (24%)
Query: 482 REGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQ 541
+ G+T LH+A N +D + LL+ GA+ NAV +G +++H+ Q
Sbjct: 629 KNGYTPLHIAAKKNQ-MD--------------IATTLLEYGADANAVTRQGIASVHLAAQ 673
Query: 542 YNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPL----DKSTTGVSEILL 589
D ++L L+ A+ +++NK TPL + V+E+L+
Sbjct: 674 EGH--VDMVSL------LLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV 717
Score = 33.9 bits (76), Expect = 0.46
Identities = 29/97 (29%), Positives = 38/97 (39%), Gaps = 23/97 (23%)
Query: 481 TREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIV 540
TR+G +HLA H + V LLL A VN + G + LH+
Sbjct: 661 TRQGIASVHLAAQEG------HVDMV---------SLLLGRNANVNLSNKSGLTPLHLAA 705
Query: 541 QYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPL 577
Q +R ++ LV GAH D K TPL
Sbjct: 706 QEDRV--------NVAEVLVNQGAHVDAQTKMGYTPL 734
Score = 30.8 bits (68), Expect = 3.9
Identities = 26/95 (27%), Positives = 38/95 (40%), Gaps = 23/95 (24%)
Query: 478 DPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALH 537
D + G T LH+A + + N V LLLD GA +A G + LH
Sbjct: 592 DAAGKSGLTPLHVAAH---------------YDNQKVALLLLDQGASPHAAAKNGYTPLH 636
Query: 538 IIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQ 572
I + N+ I +L+E GA + +Q
Sbjct: 637 IAAKKNQ--------MDIATTLLEYGADANAVTRQ 663
Score = 30.0 bits (66), Expect = 6.7
Identities = 25/97 (25%), Positives = 38/97 (39%), Gaps = 23/97 (23%)
Query: 481 TREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIV 540
T G+T LHL+ DV +F LLD GA ++ +G + LH+
Sbjct: 529 TTSGYTPLHLSAREGH-------EDVAAF--------LLDHGASLSITTKKGFTPLHVAA 573
Query: 541 QYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPL 577
+Y + + L++ A D K TPL
Sbjct: 574 KYGK--------LEVANLLLQKSASPDAAGKSGLTPL 602
Score = 30.0 bits (66), Expect = 6.7
Identities = 24/97 (24%), Positives = 36/97 (37%), Gaps = 23/97 (23%)
Query: 481 TREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIV 540
T++GFT LH+A + V LLL A +A G + LH+
Sbjct: 562 TKKGFTPLHVAAK---------------YGKLEVANLLLQKSASPDAAGKSGLTPLHVAA 606
Query: 541 QYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPL 577
Y+ + + L++ GA K TPL
Sbjct: 607 HYDN--------QKVALLLLDQGASPHAAAKNGYTPL 635
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 113 bits (282), Expect = 6e-25
Identities = 82/255 (32%), Positives = 120/255 (47%), Gaps = 33/255 (12%)
Query: 12 ASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE---- 67
AS+ + LLL+R G + + TPL AAR+GH +VV LLLE
Sbjct: 252 ASKRGNTNMVKLLLDRG--------GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 303
Query: 68 ------------HYRVQTQQTGTVRF--------DGYVIDGATALWCAAGAGHFEVVKLL 107
H Q V+ D +D TAL AA GH+ V KLL
Sbjct: 304 LLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 363
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ AN N + TPL AC R+ +++ LV+ A+I + T + +AA+ GH
Sbjct: 364 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 423
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNG-HGMTPLKVA 226
++V LL+ A P+ G TALH AA AG +++V+ L++ A + TPL +A
Sbjct: 424 NIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA 483
Query: 227 AESCKADVVELLLSH 241
+ K ++V+LLL H
Sbjct: 484 SRLGKTEIVQLLLQH 498
Score = 103 bits (258), Expect = 4e-22
Identities = 124/532 (23%), Positives = 212/532 (39%), Gaps = 101/532 (18%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
++ AA G LL R+ + R L G+ TPL IA + KV+ LL++
Sbjct: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGF---------TPLHIACKKNRIKVMELLVK 398
Query: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
+ G T + AA GH +V LL+ +GA+ + T + T L
Sbjct: 399 Y---------GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 449
Query: 128 ACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCG 187
A G++++V+ L+ N A + + + T L IA+ G T++V+ LL+ A P+A G
Sbjct: 450 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 509
Query: 188 ATALHFAAEAGHIDIVKELIKWRAA-IVVNGHGMTPLKVAAESCKADVVELLLSHADCDR 246
T LH +A G +D+ L++ AA + G TPL VAA+ DV +LLL R
Sbjct: 510 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL-----QR 564
Query: 247 RSRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRT 306
R+ ++ G + + +YD K + L +LE+ + K P+H +
Sbjct: 565 RAAADSAGKNGLTPLHVAAHYDNQK----VALLLLEK-GASPHATAKNGYTPLHIAAKKN 619
Query: 307 ECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKL 366
+ + L + + + + +G+ + D+ ++ +GA K
Sbjct: 620 QMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA------NIHMSTKS 673
Query: 367 WLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVK 426
L +LHL + ++ D+L K
Sbjct: 674 GLTSLHLAAQEDKVNVADIL--------------------------------------TK 695
Query: 427 NISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFT 486
+ +D D H + YT L + C + +N + +++ +T+ G+T
Sbjct: 696 HGADQDAHTKLG------YTPLIVACHYGNVK-------MVNFLLKQGANVNAKTKNGYT 742
Query: 487 LLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHI 538
LH A HT+ + +LL GA+ NA GN+AL I
Sbjct: 743 PLHQAAQQG------HTH---------IINVLLQHGAKPNATTANGNTALAI 779
Score = 92.0 bits (227), Expect = 1e-18
Identities = 139/560 (24%), Positives = 210/560 (37%), Gaps = 59/560 (10%)
Query: 19 TLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGT 78
T A+ L + + +L +G R L IAAR K LLL++ Q+
Sbjct: 144 TPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQS-K 202
Query: 79 VRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVK 138
+ + G T L AA G+ V LL++ GA V+ T TPL A G ++VK
Sbjct: 203 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 262
Query: 139 YLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAG 198
L++ I + T L AA GH VV LLE+ A A+ G + LH AA+
Sbjct: 263 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 322
Query: 199 HIDIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLG 257
H++ VK L++ +A + V +T L VAA V +LLL D+R+ A L G
Sbjct: 323 HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL-----DKRANPNARALNG 377
Query: 258 ASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESI 317
+ + + IK + +L ++ + + L PIH L
Sbjct: 378 FTPLHIACKKNRIKV-----MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN 432
Query: 318 RQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKG 377
D ++ G A ++V ++ GA+ EQ LH+ +
Sbjct: 433 GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT------PLHIASRL 486
Query: 378 NRNTHKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAM 437
+ LL M H PD + L I +V S A
Sbjct: 487 GKTEIVQLL-----LQHMAH-------PDAATTNGYTPLHISAREGQVDVASVLLEAGAA 534
Query: 438 DNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTP 497
+L T + + D K+ Q D + G T LH+A +
Sbjct: 535 H----SLATKKGFTPLHVAAKYGSLDVAKLLLQ--RRAAADSAGKNGLTPLHVAAH---- 584
Query: 498 VDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIII 557
+ N V LLL+ GA +A G + LHI + N+ I
Sbjct: 585 -----------YDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQ--------MQIAS 625
Query: 558 SLVEAGAHTDMTNKQNKTPL 577
+L+ GA T++ KQ TPL
Sbjct: 626 TLLNYGAETNIVTKQGVTPL 645
Score = 82.8 bits (203), Expect = 9e-16
Identities = 59/192 (30%), Positives = 95/192 (49%), Gaps = 10/192 (5%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL IAA+ ++ LL +Y +T G T L A+ GH ++V LL
Sbjct: 610 TPLHIAAKKNQMQIASTLL-NYGAETNIVTK--------QGVTPLHLASQEGHTDMVTLL 660
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ GAN++ +T + T L A + ++++ L ++ A+ K T L++A + G+
Sbjct: 661 LDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNV 720
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRA-AIVVNGHGMTPLKVA 226
+V +LL+Q A+ NAK G T LH AA+ GH I+ L++ A +G T L +A
Sbjct: 721 KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 780
Query: 227 AESCKADVVELL 238
VV+ L
Sbjct: 781 KRLGYISVVDTL 792
Score = 77.8 bits (190), Expect = 3e-14
Identities = 94/318 (29%), Positives = 141/318 (44%), Gaps = 55/318 (17%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
++ AA EG V L LL R S V + +T L IA+ G A+VV++L++
Sbjct: 47 LHLAAKEGHV-GLVQELLGRGSS--------VDSATKKGNTALHIASLAGQAEVVKVLVK 97
Query: 68 ---HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTP 124
+ Q+Q +G T L+ AA H +VVK L+ +GAN + T TP
Sbjct: 98 EGANINAQSQ------------NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 145
Query: 125 LRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLL--EQRADPNA 182
L A G V L+EN+ K L IAA K T LL + AD +
Sbjct: 146 LAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQS 201
Query: 183 K------AHCGATALHFAAEAGHIDIVKELIKWRAAIVVNG-HGMTPLKVAAESCKADVV 235
K G T LH AA G++++ L+ AA+ +G+TPL VA++ ++V
Sbjct: 202 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 261
Query: 236 ELLLSHADCDRRSRIEALELLGAS--FANDRENYD-IIKTYHYLYLAMLERFQDGDNILE 292
+LLL DR +I+A G + R +D +++ +L R ++G
Sbjct: 262 KLLL-----DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG----- 311
Query: 293 KEVLPPIH--AYGNRTEC 308
L P+H A G+ EC
Sbjct: 312 ---LSPLHMAAQGDHVEC 326
Score = 76.3 bits (186), Expect = 8e-14
Identities = 51/162 (31%), Positives = 84/162 (51%), Gaps = 2/162 (1%)
Query: 95 AAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYD 154
AA AG+ + V + G ++N L A +G + +V+ L+ +++ A K
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 155 NTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRA-AI 213
NT L IA+ G +VV+ L+++ A+ NA++ G T L+ AA+ HID+VK L++ A
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136
Query: 214 VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALEL 255
G TPL VA + V +LL + D + R+ AL +
Sbjct: 137 TATEDGFTPLAVALQQGHNQAVAILLEN-DTKGKVRLPALHI 177
Score = 76.3 bits (186), Expect = 8e-14
Identities = 66/226 (29%), Positives = 99/226 (43%), Gaps = 46/226 (20%)
Query: 87 DGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNAN 146
+G AL AA GH +V+ L+ G++V+ T +T L A G+ ++VK LV+ AN
Sbjct: 42 NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 101
Query: 147 ISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIV--- 203
I+ ++ T L +AA + H DVV+YLLE A+ + G T L A + GH V
Sbjct: 102 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 161
Query: 204 -------------------KELIKWRAAIVVNGH----------------GMTPLKVAAE 228
K+ K A ++ N H G TPL +AA
Sbjct: 162 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 221
Query: 229 SCKADVVELLLSH---ADCDRRSRIEALELLGASFANDRENYDIIK 271
+V LLL+ D R+ I L + A+ R N +++K
Sbjct: 222 YGNVNVATLLLNRGAAVDFTARNGITPLHV-----ASKRGNTNMVK 262
Score = 54.3 bits (129), Expect = 3e-07
Identities = 109/485 (22%), Positives = 191/485 (39%), Gaps = 110/485 (22%)
Query: 155 NTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI- 213
N + AA G+ D V L+ D N G ALH AA+ GH+ +V+EL+ +++
Sbjct: 11 NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 70
Query: 214 VVNGHGMTPLKVAAESCKADVVELLLSH-ADCDRRSRIEALELLGASFANDRENYDIIKT 272
G T L +A+ + +A+VV++L+ A+ + +S+ L A+ N + D++K
Sbjct: 71 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQEN---HIDVVK- 126
Query: 273 YHYL--------------YLAMLERFQDGDN-----ILEKEV-----LPPIHAYGNRTEC 308
YL + + Q G N +LE + LP +H + +
Sbjct: 127 --YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDT 184
Query: 309 RNPQELESIRQDRDALHMEGLIVRERILGA----------DNIDVSHPIIYRGAVYADNM 358
++ L ++ D +A ++V N++V+ ++ RGA
Sbjct: 185 KSAALL--LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA----- 237
Query: 359 EFEQCIKLWLHALHLRQK-GNRNTHKDLL-RFAQVFSQMIHLNETVKAPDIECVLRCSV- 415
+ + + LH+ K GN N K LL R Q+ K D L C+
Sbjct: 238 -VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI---------DAKTRDGLTPLHCAAR 287
Query: 416 --------LEIEQS---MNRVKN-ISDADVHNAMDNYECNLY-----------TFLYLVC 452
L +E+ + R KN +S + D+ EC + T YL
Sbjct: 288 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347
Query: 453 ISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNA 512
+ C K+ + + + R GFT LH+A N
Sbjct: 348 LHVAAHCGHYRVTKL--LLDKRANPNARALNGFTPLHIACKKN---------------RI 390
Query: 513 LVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQ 572
V +LL+ GA + A+ G + +H ++ F+ +I++ L++ GA D+TN +
Sbjct: 391 KVMELLVKYGASIQAITESGLTPIH--------VAAFMGHLNIVLLLLQNGASPDVTNIR 442
Query: 573 NKTPL 577
+T L
Sbjct: 443 GETAL 447
Score = 36.2 bits (82), Expect = 0.093
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 27/113 (23%)
Query: 482 REGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQ 541
+ G+T LH+A N + LL+ GAE N V +G + LH+ Q
Sbjct: 606 KNGYTPLHIAAKKN---------------QMQIASTLLNYGAETNIVTKQGVTPLHLASQ 650
Query: 542 YNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPL----DKSTTGVSEILLK 590
+D +TL L++ GA+ M+ K T L + V++IL K
Sbjct: 651 EGH--TDMVTL------LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 695
Score = 32.7 bits (73), Expect = 1.0
Identities = 31/134 (23%), Positives = 51/134 (38%), Gaps = 26/134 (19%)
Query: 468 NKQIYNLIHLDPRTREGFTLLHLA------------VNSNTPVDDFHTNDVCSFP----- 510
N + + + ++ T GFT LH+A +N VD N +
Sbjct: 196 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 255
Query: 511 -NALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMT 569
N + KLLLD G +++A +G + LH + ++ L+E GA
Sbjct: 256 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH--------DQVVELLLERGAPLLAR 307
Query: 570 NKQNKTPLDKSTTG 583
K +PL + G
Sbjct: 308 TKNGLSPLHMAAQG 321
Score = 31.6 bits (70), Expect = 2.3
Identities = 34/122 (27%), Positives = 45/122 (36%), Gaps = 30/122 (24%)
Query: 475 IHLDPRTREGFTLLHLAVNSNT-----------PVDDFHTN-------DVCSFPNALVTK 516
IH+ T+ G T LHLA + D HT C + N +
Sbjct: 667 IHMS--TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 724
Query: 517 LLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIIS-LVEAGAHTDMTNKQNKT 575
LL GA VNA G + LH Q H+ II+ L++ GA + T T
Sbjct: 725 FLLKQGANVNAKTKNGYTPLHQAAQQG---------HTHIINVLLQHGAKPNATTANGNT 775
Query: 576 PL 577
L
Sbjct: 776 AL 777
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 113 bits (282), Expect = 6e-25
Identities = 82/255 (32%), Positives = 120/255 (47%), Gaps = 33/255 (12%)
Query: 12 ASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE---- 67
AS+ + LLL+R G + + TPL AAR+GH +VV LLLE
Sbjct: 273 ASKRGNTNMVKLLLDRG--------GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324
Query: 68 ------------HYRVQTQQTGTVRF--------DGYVIDGATALWCAAGAGHFEVVKLL 107
H Q V+ D +D TAL AA GH+ V KLL
Sbjct: 325 LLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ AN N + TPL AC R+ +++ LV+ A+I + T + +AA+ GH
Sbjct: 385 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 444
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNG-HGMTPLKVA 226
++V LL+ A P+ G TALH AA AG +++V+ L++ A + TPL +A
Sbjct: 445 NIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA 504
Query: 227 AESCKADVVELLLSH 241
+ K ++V+LLL H
Sbjct: 505 SRLGKTEIVQLLLQH 519
Score = 103 bits (258), Expect = 4e-22
Identities = 124/532 (23%), Positives = 212/532 (39%), Gaps = 101/532 (18%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
++ AA G LL R+ + R L G+ TPL IA + KV+ LL++
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARALNGF---------TPLHIACKKNRIKVMELLVK 419
Query: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
+ G T + AA GH +V LL+ +GA+ + T + T L
Sbjct: 420 Y---------GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 470
Query: 128 ACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCG 187
A G++++V+ L+ N A + + + T L IA+ G T++V+ LL+ A P+A G
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530
Query: 188 ATALHFAAEAGHIDIVKELIKWRAA-IVVNGHGMTPLKVAAESCKADVVELLLSHADCDR 246
T LH +A G +D+ L++ AA + G TPL VAA+ DV +LLL R
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL-----QR 585
Query: 247 RSRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRT 306
R+ ++ G + + +YD K + L +LE+ + K P+H +
Sbjct: 586 RAAADSAGKNGLTPLHVAAHYDNQK----VALLLLEK-GASPHATAKNGYTPLHIAAKKN 640
Query: 307 ECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKL 366
+ + L + + + + +G+ + D+ ++ +GA K
Sbjct: 641 QMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA------NIHMSTKS 694
Query: 367 WLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVK 426
L +LHL + ++ D+L K
Sbjct: 695 GLTSLHLAAQEDKVNVADIL--------------------------------------TK 716
Query: 427 NISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFT 486
+ +D D H + YT L + C + +N + +++ +T+ G+T
Sbjct: 717 HGADQDAHTKLG------YTPLIVACHYGNVK-------MVNFLLKQGANVNAKTKNGYT 763
Query: 487 LLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHI 538
LH A HT+ + +LL GA+ NA GN+AL I
Sbjct: 764 PLHQAAQQG------HTH---------IINVLLQHGAKPNATTANGNTALAI 800
Score = 92.0 bits (227), Expect = 1e-18
Identities = 139/560 (24%), Positives = 210/560 (37%), Gaps = 59/560 (10%)
Query: 19 TLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGT 78
T A+ L + + +L +G R L IAAR K LLL++ Q+
Sbjct: 165 TPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQS-K 223
Query: 79 VRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVK 138
+ + G T L AA G+ V LL++ GA V+ T TPL A G ++VK
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283
Query: 139 YLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAG 198
L++ I + T L AA GH VV LLE+ A A+ G + LH AA+
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343
Query: 199 HIDIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLG 257
H++ VK L++ +A + V +T L VAA V +LLL D+R+ A L G
Sbjct: 344 HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL-----DKRANPNARALNG 398
Query: 258 ASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESI 317
+ + + IK + +L ++ + + L PIH L
Sbjct: 399 FTPLHIACKKNRIKV-----MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN 453
Query: 318 RQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKG 377
D ++ G A ++V ++ GA+ EQ LH+ +
Sbjct: 454 GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT------PLHIASRL 507
Query: 378 NRNTHKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAM 437
+ LL M H PD + L I +V S A
Sbjct: 508 GKTEIVQLL-----LQHMAH-------PDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 438 DNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTP 497
+L T + + D K+ Q D + G T LH+A +
Sbjct: 556 H----SLATKKGFTPLHVAAKYGSLDVAKLLLQ--RRAAADSAGKNGLTPLHVAAH---- 605
Query: 498 VDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIII 557
+ N V LLL+ GA +A G + LHI + N+ I
Sbjct: 606 -----------YDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQ--------MQIAS 646
Query: 558 SLVEAGAHTDMTNKQNKTPL 577
+L+ GA T++ KQ TPL
Sbjct: 647 TLLNYGAETNIVTKQGVTPL 666
Score = 82.8 bits (203), Expect = 9e-16
Identities = 59/192 (30%), Positives = 95/192 (49%), Gaps = 10/192 (5%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL IAA+ ++ LL +Y +T G T L A+ GH ++V LL
Sbjct: 631 TPLHIAAKKNQMQIASTLL-NYGAETNIVTK--------QGVTPLHLASQEGHTDMVTLL 681
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ GAN++ +T + T L A + ++++ L ++ A+ K T L++A + G+
Sbjct: 682 LDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNV 741
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRA-AIVVNGHGMTPLKVA 226
+V +LL+Q A+ NAK G T LH AA+ GH I+ L++ A +G T L +A
Sbjct: 742 KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
Query: 227 AESCKADVVELL 238
VV+ L
Sbjct: 802 KRLGYISVVDTL 813
Score = 77.8 bits (190), Expect = 3e-14
Identities = 94/318 (29%), Positives = 141/318 (44%), Gaps = 55/318 (17%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
++ AA EG V L LL R S V + +T L IA+ G A+VV++L++
Sbjct: 68 LHLAAKEGHV-GLVQELLGRGSS--------VDSATKKGNTALHIASLAGQAEVVKVLVK 118
Query: 68 ---HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTP 124
+ Q+Q +G T L+ AA H +VVK L+ +GAN + T TP
Sbjct: 119 EGANINAQSQ------------NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166
Query: 125 LRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLL--EQRADPNA 182
L A G V L+EN+ K L IAA K T LL + AD +
Sbjct: 167 LAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQS 222
Query: 183 K------AHCGATALHFAAEAGHIDIVKELIKWRAAIVVNG-HGMTPLKVAAESCKADVV 235
K G T LH AA G++++ L+ AA+ +G+TPL VA++ ++V
Sbjct: 223 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 282
Query: 236 ELLLSHADCDRRSRIEALELLGAS--FANDRENYD-IIKTYHYLYLAMLERFQDGDNILE 292
+LLL DR +I+A G + R +D +++ +L R ++G
Sbjct: 283 KLLL-----DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG----- 332
Query: 293 KEVLPPIH--AYGNRTEC 308
L P+H A G+ EC
Sbjct: 333 ---LSPLHMAAQGDHVEC 347
Score = 76.3 bits (186), Expect = 8e-14
Identities = 51/162 (31%), Positives = 84/162 (51%), Gaps = 2/162 (1%)
Query: 95 AAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYD 154
AA AG+ + V + G ++N L A +G + +V+ L+ +++ A K
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 155 NTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRA-AI 213
NT L IA+ G +VV+ L+++ A+ NA++ G T L+ AA+ HID+VK L++ A
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 214 VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALEL 255
G TPL VA + V +LL + D + R+ AL +
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLEN-DTKGKVRLPALHI 198
Score = 76.3 bits (186), Expect = 8e-14
Identities = 66/226 (29%), Positives = 99/226 (43%), Gaps = 46/226 (20%)
Query: 87 DGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNAN 146
+G AL AA GH +V+ L+ G++V+ T +T L A G+ ++VK LV+ AN
Sbjct: 63 NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 122
Query: 147 ISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIV--- 203
I+ ++ T L +AA + H DVV+YLLE A+ + G T L A + GH V
Sbjct: 123 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Query: 204 -------------------KELIKWRAAIVVNGH----------------GMTPLKVAAE 228
K+ K A ++ N H G TPL +AA
Sbjct: 183 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242
Query: 229 SCKADVVELLLSH---ADCDRRSRIEALELLGASFANDRENYDIIK 271
+V LLL+ D R+ I L + A+ R N +++K
Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHV-----ASKRGNTNMVK 283
Score = 54.3 bits (129), Expect = 3e-07
Identities = 109/485 (22%), Positives = 191/485 (39%), Gaps = 110/485 (22%)
Query: 155 NTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI- 213
N + AA G+ D V L+ D N G ALH AA+ GH+ +V+EL+ +++
Sbjct: 32 NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 91
Query: 214 VVNGHGMTPLKVAAESCKADVVELLLSH-ADCDRRSRIEALELLGASFANDRENYDIIKT 272
G T L +A+ + +A+VV++L+ A+ + +S+ L A+ N + D++K
Sbjct: 92 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQEN---HIDVVK- 147
Query: 273 YHYL--------------YLAMLERFQDGDN-----ILEKEV-----LPPIHAYGNRTEC 308
YL + + Q G N +LE + LP +H + +
Sbjct: 148 --YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDT 205
Query: 309 RNPQELESIRQDRDALHMEGLIVRERILGA----------DNIDVSHPIIYRGAVYADNM 358
++ L ++ D +A ++V N++V+ ++ RGA
Sbjct: 206 KSAALL--LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA----- 258
Query: 359 EFEQCIKLWLHALHLRQK-GNRNTHKDLL-RFAQVFSQMIHLNETVKAPDIECVLRCSV- 415
+ + + LH+ K GN N K LL R Q+ K D L C+
Sbjct: 259 -VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI---------DAKTRDGLTPLHCAAR 308
Query: 416 --------LEIEQS---MNRVKN-ISDADVHNAMDNYECNLY-----------TFLYLVC 452
L +E+ + R KN +S + D+ EC + T YL
Sbjct: 309 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 368
Query: 453 ISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNA 512
+ C K+ + + + R GFT LH+A N
Sbjct: 369 LHVAAHCGHYRVTKL--LLDKRANPNARALNGFTPLHIACKKN---------------RI 411
Query: 513 LVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQ 572
V +LL+ GA + A+ G + +H ++ F+ +I++ L++ GA D+TN +
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIH--------VAAFMGHLNIVLLLLQNGASPDVTNIR 463
Query: 573 NKTPL 577
+T L
Sbjct: 464 GETAL 468
Score = 36.2 bits (82), Expect = 0.093
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 27/113 (23%)
Query: 482 REGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQ 541
+ G+T LH+A N + LL+ GAE N V +G + LH+ Q
Sbjct: 627 KNGYTPLHIAAKKN---------------QMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671
Query: 542 YNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPL----DKSTTGVSEILLK 590
+D +TL L++ GA+ M+ K T L + V++IL K
Sbjct: 672 EGH--TDMVTL------LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716
Score = 32.7 bits (73), Expect = 1.0
Identities = 31/134 (23%), Positives = 51/134 (38%), Gaps = 26/134 (19%)
Query: 468 NKQIYNLIHLDPRTREGFTLLHLA------------VNSNTPVDDFHTNDVCSFP----- 510
N + + + ++ T GFT LH+A +N VD N +
Sbjct: 217 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 276
Query: 511 -NALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMT 569
N + KLLLD G +++A +G + LH + ++ L+E GA
Sbjct: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH--------DQVVELLLERGAPLLAR 328
Query: 570 NKQNKTPLDKSTTG 583
K +PL + G
Sbjct: 329 TKNGLSPLHMAAQG 342
Score = 31.6 bits (70), Expect = 2.3
Identities = 34/122 (27%), Positives = 45/122 (36%), Gaps = 30/122 (24%)
Query: 475 IHLDPRTREGFTLLHLAVNSNT-----------PVDDFHTN-------DVCSFPNALVTK 516
IH+ T+ G T LHLA + D HT C + N +
Sbjct: 688 IHMS--TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 745
Query: 517 LLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIIS-LVEAGAHTDMTNKQNKT 575
LL GA VNA G + LH Q H+ II+ L++ GA + T T
Sbjct: 746 FLLKQGANVNAKTKNGYTPLHQAAQQG---------HTHIINVLLQHGAKPNATTANGNT 796
Query: 576 PL 577
L
Sbjct: 797 AL 798
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 113 bits (282), Expect = 6e-25
Identities = 82/255 (32%), Positives = 120/255 (47%), Gaps = 33/255 (12%)
Query: 12 ASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE---- 67
AS+ + LLL+R G + + TPL AAR+GH +VV LLLE
Sbjct: 273 ASKRGNTNMVKLLLDRG--------GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324
Query: 68 ------------HYRVQTQQTGTVRF--------DGYVIDGATALWCAAGAGHFEVVKLL 107
H Q V+ D +D TAL AA GH+ V KLL
Sbjct: 325 LLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ AN N + TPL AC R+ +++ LV+ A+I + T + +AA+ GH
Sbjct: 385 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 444
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNG-HGMTPLKVA 226
++V LL+ A P+ G TALH AA AG +++V+ L++ A + TPL +A
Sbjct: 445 NIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA 504
Query: 227 AESCKADVVELLLSH 241
+ K ++V+LLL H
Sbjct: 505 SRLGKTEIVQLLLQH 519
Score = 103 bits (258), Expect = 4e-22
Identities = 124/532 (23%), Positives = 212/532 (39%), Gaps = 101/532 (18%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
++ AA G LL R+ + R L G+ TPL IA + KV+ LL++
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARALNGF---------TPLHIACKKNRIKVMELLVK 419
Query: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
+ G T + AA GH +V LL+ +GA+ + T + T L
Sbjct: 420 Y---------GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 470
Query: 128 ACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCG 187
A G++++V+ L+ N A + + + T L IA+ G T++V+ LL+ A P+A G
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530
Query: 188 ATALHFAAEAGHIDIVKELIKWRAA-IVVNGHGMTPLKVAAESCKADVVELLLSHADCDR 246
T LH +A G +D+ L++ AA + G TPL VAA+ DV +LLL R
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL-----QR 585
Query: 247 RSRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRT 306
R+ ++ G + + +YD K + L +LE+ + K P+H +
Sbjct: 586 RAAADSAGKNGLTPLHVAAHYDNQK----VALLLLEK-GASPHATAKNGYTPLHIAAKKN 640
Query: 307 ECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKL 366
+ + L + + + + +G+ + D+ ++ +GA K
Sbjct: 641 QMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA------NIHMSTKS 694
Query: 367 WLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVK 426
L +LHL + ++ D+L K
Sbjct: 695 GLTSLHLAAQEDKVNVADIL--------------------------------------TK 716
Query: 427 NISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFT 486
+ +D D H + YT L + C + +N + +++ +T+ G+T
Sbjct: 717 HGADQDAHTKLG------YTPLIVACHYGNVK-------MVNFLLKQGANVNAKTKNGYT 763
Query: 487 LLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHI 538
LH A HT+ + +LL GA+ NA GN+AL I
Sbjct: 764 PLHQAAQQG------HTH---------IINVLLQHGAKPNATTANGNTALAI 800
Score = 92.0 bits (227), Expect = 1e-18
Identities = 139/560 (24%), Positives = 210/560 (37%), Gaps = 59/560 (10%)
Query: 19 TLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGT 78
T A+ L + + +L +G R L IAAR K LLL++ Q+
Sbjct: 165 TPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQS-K 223
Query: 79 VRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVK 138
+ + G T L AA G+ V LL++ GA V+ T TPL A G ++VK
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283
Query: 139 YLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAG 198
L++ I + T L AA GH VV LLE+ A A+ G + LH AA+
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343
Query: 199 HIDIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLG 257
H++ VK L++ +A + V +T L VAA V +LLL D+R+ A L G
Sbjct: 344 HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL-----DKRANPNARALNG 398
Query: 258 ASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESI 317
+ + + IK + +L ++ + + L PIH L
Sbjct: 399 FTPLHIACKKNRIKV-----MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN 453
Query: 318 RQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKG 377
D ++ G A ++V ++ GA+ EQ LH+ +
Sbjct: 454 GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT------PLHIASRL 507
Query: 378 NRNTHKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAM 437
+ LL M H PD + L I +V S A
Sbjct: 508 GKTEIVQLL-----LQHMAH-------PDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 438 DNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTP 497
+L T + + D K+ Q D + G T LH+A +
Sbjct: 556 H----SLATKKGFTPLHVAAKYGSLDVAKLLLQ--RRAAADSAGKNGLTPLHVAAH---- 605
Query: 498 VDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIII 557
+ N V LLL+ GA +A G + LHI + N+ I
Sbjct: 606 -----------YDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQ--------MQIAS 646
Query: 558 SLVEAGAHTDMTNKQNKTPL 577
+L+ GA T++ KQ TPL
Sbjct: 647 TLLNYGAETNIVTKQGVTPL 666
Score = 82.8 bits (203), Expect = 9e-16
Identities = 59/192 (30%), Positives = 95/192 (49%), Gaps = 10/192 (5%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL IAA+ ++ LL +Y +T G T L A+ GH ++V LL
Sbjct: 631 TPLHIAAKKNQMQIASTLL-NYGAETNIVTK--------QGVTPLHLASQEGHTDMVTLL 681
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ GAN++ +T + T L A + ++++ L ++ A+ K T L++A + G+
Sbjct: 682 LDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNV 741
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRA-AIVVNGHGMTPLKVA 226
+V +LL+Q A+ NAK G T LH AA+ GH I+ L++ A +G T L +A
Sbjct: 742 KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
Query: 227 AESCKADVVELL 238
VV+ L
Sbjct: 802 KRLGYISVVDTL 813
Score = 77.8 bits (190), Expect = 3e-14
Identities = 94/318 (29%), Positives = 141/318 (44%), Gaps = 55/318 (17%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
++ AA EG V L LL R S V + +T L IA+ G A+VV++L++
Sbjct: 68 LHLAAKEGHV-GLVQELLGRGSS--------VDSATKKGNTALHIASLAGQAEVVKVLVK 118
Query: 68 ---HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTP 124
+ Q+Q +G T L+ AA H +VVK L+ +GAN + T TP
Sbjct: 119 EGANINAQSQ------------NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166
Query: 125 LRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLL--EQRADPNA 182
L A G V L+EN+ K L IAA K T LL + AD +
Sbjct: 167 LAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQS 222
Query: 183 K------AHCGATALHFAAEAGHIDIVKELIKWRAAIVVNG-HGMTPLKVAAESCKADVV 235
K G T LH AA G++++ L+ AA+ +G+TPL VA++ ++V
Sbjct: 223 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 282
Query: 236 ELLLSHADCDRRSRIEALELLGAS--FANDRENYD-IIKTYHYLYLAMLERFQDGDNILE 292
+LLL DR +I+A G + R +D +++ +L R ++G
Sbjct: 283 KLLL-----DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG----- 332
Query: 293 KEVLPPIH--AYGNRTEC 308
L P+H A G+ EC
Sbjct: 333 ---LSPLHMAAQGDHVEC 347
Score = 76.3 bits (186), Expect = 8e-14
Identities = 51/162 (31%), Positives = 84/162 (51%), Gaps = 2/162 (1%)
Query: 95 AAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYD 154
AA AG+ + V + G ++N L A +G + +V+ L+ +++ A K
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 155 NTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRA-AI 213
NT L IA+ G +VV+ L+++ A+ NA++ G T L+ AA+ HID+VK L++ A
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 214 VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALEL 255
G TPL VA + V +LL + D + R+ AL +
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLEN-DTKGKVRLPALHI 198
Score = 76.3 bits (186), Expect = 8e-14
Identities = 66/226 (29%), Positives = 99/226 (43%), Gaps = 46/226 (20%)
Query: 87 DGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNAN 146
+G AL AA GH +V+ L+ G++V+ T +T L A G+ ++VK LV+ AN
Sbjct: 63 NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 122
Query: 147 ISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIV--- 203
I+ ++ T L +AA + H DVV+YLLE A+ + G T L A + GH V
Sbjct: 123 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Query: 204 -------------------KELIKWRAAIVVNGH----------------GMTPLKVAAE 228
K+ K A ++ N H G TPL +AA
Sbjct: 183 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242
Query: 229 SCKADVVELLLSH---ADCDRRSRIEALELLGASFANDRENYDIIK 271
+V LLL+ D R+ I L + A+ R N +++K
Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHV-----ASKRGNTNMVK 283
Score = 54.3 bits (129), Expect = 3e-07
Identities = 109/485 (22%), Positives = 191/485 (39%), Gaps = 110/485 (22%)
Query: 155 NTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI- 213
N + AA G+ D V L+ D N G ALH AA+ GH+ +V+EL+ +++
Sbjct: 32 NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 91
Query: 214 VVNGHGMTPLKVAAESCKADVVELLLSH-ADCDRRSRIEALELLGASFANDRENYDIIKT 272
G T L +A+ + +A+VV++L+ A+ + +S+ L A+ N + D++K
Sbjct: 92 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQEN---HIDVVK- 147
Query: 273 YHYL--------------YLAMLERFQDGDN-----ILEKEV-----LPPIHAYGNRTEC 308
YL + + Q G N +LE + LP +H + +
Sbjct: 148 --YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDT 205
Query: 309 RNPQELESIRQDRDALHMEGLIVRERILGA----------DNIDVSHPIIYRGAVYADNM 358
++ L ++ D +A ++V N++V+ ++ RGA
Sbjct: 206 KSAALL--LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA----- 258
Query: 359 EFEQCIKLWLHALHLRQK-GNRNTHKDLL-RFAQVFSQMIHLNETVKAPDIECVLRCSV- 415
+ + + LH+ K GN N K LL R Q+ K D L C+
Sbjct: 259 -VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI---------DAKTRDGLTPLHCAAR 308
Query: 416 --------LEIEQS---MNRVKN-ISDADVHNAMDNYECNLY-----------TFLYLVC 452
L +E+ + R KN +S + D+ EC + T YL
Sbjct: 309 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 368
Query: 453 ISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNA 512
+ C K+ + + + R GFT LH+A N
Sbjct: 369 LHVAAHCGHYRVTKL--LLDKRANPNARALNGFTPLHIACKKN---------------RI 411
Query: 513 LVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQ 572
V +LL+ GA + A+ G + +H ++ F+ +I++ L++ GA D+TN +
Sbjct: 412 KVMELLVKYGASIQAITESGLTPIH--------VAAFMGHLNIVLLLLQNGASPDVTNIR 463
Query: 573 NKTPL 577
+T L
Sbjct: 464 GETAL 468
Score = 36.2 bits (82), Expect = 0.093
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 27/113 (23%)
Query: 482 REGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQ 541
+ G+T LH+A N + LL+ GAE N V +G + LH+ Q
Sbjct: 627 KNGYTPLHIAAKKN---------------QMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671
Query: 542 YNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPL----DKSTTGVSEILLK 590
+D +TL L++ GA+ M+ K T L + V++IL K
Sbjct: 672 EGH--TDMVTL------LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716
Score = 32.7 bits (73), Expect = 1.0
Identities = 31/134 (23%), Positives = 51/134 (38%), Gaps = 26/134 (19%)
Query: 468 NKQIYNLIHLDPRTREGFTLLHLA------------VNSNTPVDDFHTNDVCSFP----- 510
N + + + ++ T GFT LH+A +N VD N +
Sbjct: 217 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 276
Query: 511 -NALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMT 569
N + KLLLD G +++A +G + LH + ++ L+E GA
Sbjct: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH--------DQVVELLLERGAPLLAR 328
Query: 570 NKQNKTPLDKSTTG 583
K +PL + G
Sbjct: 329 TKNGLSPLHMAAQG 342
Score = 31.6 bits (70), Expect = 2.3
Identities = 34/122 (27%), Positives = 45/122 (36%), Gaps = 30/122 (24%)
Query: 475 IHLDPRTREGFTLLHLAVNSNT-----------PVDDFHTN-------DVCSFPNALVTK 516
IH+ T+ G T LHLA + D HT C + N +
Sbjct: 688 IHMS--TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVN 745
Query: 517 LLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIIS-LVEAGAHTDMTNKQNKT 575
LL GA VNA G + LH Q H+ II+ L++ GA + T T
Sbjct: 746 FLLKQGANVNAKTKNGYTPLHQAAQQG---------HTHIINVLLQHGAKPNATTANGNT 796
Query: 576 PL 577
L
Sbjct: 797 AL 798
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 104 bits (259), Expect = 3e-22
Identities = 75/226 (33%), Positives = 113/226 (50%), Gaps = 10/226 (4%)
Query: 39 VSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGA 98
++ Q +T L AA+ GH VVR L +T DG TAL A+
Sbjct: 72 INLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTK---------DGGTALLAASQY 122
Query: 99 GHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCL 158
GH +VV+ L+ HGAN++ +T L A G LD+++ L+ + A ++ + L
Sbjct: 123 GHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPL 182
Query: 159 MIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGH 218
IA+ GH++VVR +L + AD +A + G TAL AA G+ D++KEL+K+ + + +
Sbjct: 183 WIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKN 242
Query: 219 GMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDR 264
G + L A S V LLL A D R +A EL N+R
Sbjct: 243 GTSALHAAVLSGNIKTVALLL-EAGADPSLRNKANELPAELTKNER 287
Score = 90.9 bits (224), Expect = 3e-18
Identities = 77/233 (33%), Positives = 116/233 (49%), Gaps = 17/233 (7%)
Query: 45 QRSTPL----IIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGH 100
++ TPL AAR G+ +++LLL +G V D G T L AA AGH
Sbjct: 7 KKETPLANAAFWAARRGNLALLKLLLN--------SGRVDVDCRDSHGTTLLMVAAYAGH 58
Query: 101 FEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMI 160
+ V+ LV GA++N + +T L A G D+V++L A+ K T L+
Sbjct: 59 IDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLA 118
Query: 161 AAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI-VVNGHG 219
A+ GH VV LL+ A+ + + + GATAL AA+ G++D+++ L+ A + G
Sbjct: 119 ASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDG 178
Query: 220 MTPLKVAAESCKADVVE-LLLSHADCDRRSRIEALELLGASFANDRENYDIIK 271
PL +A++ ++VV +LL AD D LL A AN N D+IK
Sbjct: 179 TAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKA--ANKGYN-DVIK 228
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 104 bits (259), Expect = 3e-22
Identities = 67/194 (34%), Positives = 105/194 (54%), Gaps = 10/194 (5%)
Query: 49 PLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLV 108
P I+A++ GH V++LLE+ Q+ GY DG AL AA GH ++V+LL
Sbjct: 883 PFILASQEGHYDCVQILLENKSNIDQR-------GY--DGRNALRVAALEGHRDIVELLF 933
Query: 109 SHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTD 168
SHGA+VN L + +L + +Y +EN AN+ ++ T L ++ ++GH +
Sbjct: 934 SHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHME 993
Query: 169 VVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI-VVNGHGMTPLKVAA 227
+V+ L+ AD NA + +AL AA GH+ +V+ LI+ A + G T L +AA
Sbjct: 994 MVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAA 1053
Query: 228 ESCKADVVELLLSH 241
+ DVV++LL H
Sbjct: 1054 QEGHIDVVQVLLEH 1067
Score = 98.6 bits (244), Expect = 2e-20
Identities = 86/264 (32%), Positives = 127/264 (48%), Gaps = 27/264 (10%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGY---VSQQGGQRSTPLIIAA-----RNGHA 59
V KA +EG+ +AA + E + +LL + V+ + T L +AA GHA
Sbjct: 670 VNKADNEGRTALIAAAYMGHREI-VEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHA 728
Query: 60 KVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTV 119
VV LL++ D DG T L AA GH +VV LL+ GA+V+HT
Sbjct: 729 SVVSLLIDR---------GAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDN 779
Query: 120 TNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRAD 179
TPL AA G +V L+ A + + T L IA+ +G+ +VVR LL++ D
Sbjct: 780 NGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLD 839
Query: 180 PNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELL 238
N + G T LH AA GH I + LI+ A ++ G P +A++ D V++L
Sbjct: 840 ENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 899
Query: 239 LSH-ADCDRRS-------RIEALE 254
L + ++ D+R R+ ALE
Sbjct: 900 LENKSNIDQRGYDGRNALRVAALE 923
Score = 95.1 bits (235), Expect = 2e-19
Identities = 73/237 (30%), Positives = 111/237 (46%), Gaps = 34/237 (14%)
Query: 11 AASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEH-- 68
A+ EG + LL N+S D Q+G L +AA GH +V LL H
Sbjct: 887 ASQEGHYDCVQILLENKSNID---------QRGYDGRNALRVAALEGHRDIVELLFSHGA 937
Query: 69 ---------------YRVQTQQTGTVRF-------DGYVIDGATALWCAAGAGHFEVVKL 106
++ Q T F + +G TAL + GH E+V++
Sbjct: 938 DVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQV 997
Query: 107 LVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGH 166
L+++ A+VN + L++A + G + +V+ L+E+ A + T L IAA +GH
Sbjct: 998 LIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGH 1057
Query: 167 TDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPL 223
DVV+ LLE ADPN G TA+ AA+ GH I+K L K+ A+ +NG +P+
Sbjct: 1058 IDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS-SLNGCSPSPV 1113
Score = 88.2 bits (217), Expect = 2e-17
Identities = 88/274 (32%), Positives = 113/274 (41%), Gaps = 52/274 (18%)
Query: 29 ESDIRYLL---GYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYV 85
E IR LL V+Q T L AA +G VV LL+ +
Sbjct: 525 EDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDA-------- 576
Query: 86 IDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNA 145
G T L AA GH +VV L+ GAN+NHT T LR+A + G ++V L+
Sbjct: 577 -HGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGV 635
Query: 146 NISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKE 205
+ A+ T L AA+ GH D+V LL+ A+ N + G TAL AA GH +IV+
Sbjct: 636 KVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEH 695
Query: 206 L-----------IKWRAAIVV--------NGH--------------------GMTPLKVA 226
L + R A+ V GH GMTPL VA
Sbjct: 696 LLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVA 755
Query: 227 AESCKADVVELLL-SHADCDRRSRIEALELLGAS 259
A DVV+LLL AD D LL A+
Sbjct: 756 AYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAA 789
Score = 82.8 bits (203), Expect = 9e-16
Identities = 69/234 (29%), Positives = 102/234 (43%), Gaps = 21/234 (8%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVID-----GATALWCAAGAGHFE 102
TPL+ AA GHA VV LL F G +D G T L A+ G+ E
Sbjct: 783 TPLLAAASMGHASVVNTLL--------------FWGAAVDSIDSEGRTVLSIASAQGNVE 828
Query: 103 VVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAA 162
VV+ L+ G + NH TPL A F+G I + L+E A + + ++A+
Sbjct: 829 VVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILAS 888
Query: 163 YKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI-VVNGHGMT 221
+GH D V+ LLE +++ + + + G AL AA GH DIV+ L A + + G
Sbjct: 889 QEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRP 948
Query: 222 PLKVAAESCKADVVELLLSHADCDRRSRIEALELLGAS-FANDRENYDIIKTYH 274
L + A + + E L + S E L S + E ++ YH
Sbjct: 949 TLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYH 1002
Score = 79.3 bits (194), Expect = 1e-14
Identities = 56/195 (28%), Positives = 91/195 (46%), Gaps = 10/195 (5%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL +AA GH + L+E Q T D DG A+ GH++ V++L
Sbjct: 849 TPLHMAAFEGHRLICEALIE------QGARTNEIDN---DGRIPFILASQEGHYDCVQIL 899
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ + +N++ LR A +G DIV+ L + A+++ + L I A +
Sbjct: 900 LENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQL 959
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI-VVNGHGMTPLKVA 226
+ Y LE A+ A G TALH + GH+++V+ LI + A + + + L+ A
Sbjct: 960 TMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSA 1019
Query: 227 AESCKADVVELLLSH 241
A VV+LL+ H
Sbjct: 1020 AWQGHVKVVQLLIEH 1034
Score = 63.9 bits (154), Expect = 4e-10
Identities = 55/158 (34%), Positives = 76/158 (48%), Gaps = 9/158 (5%)
Query: 102 EVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIA 161
EV++LLV GA+VN S +R A R D ++ L++N A+++ + T L A
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQAL--EREDSIRTLLDNGASVNQCDSNGRTLLANA 552
Query: 162 AYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI-VVNGHGM 220
AY G DVV L+ + AD + G T L AA GH +V LI A I + G
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612
Query: 221 TPLKVAAESCKADVVELLL------SHADCDRRSRIEA 252
T L+ AA +VV LL AD D R+ + A
Sbjct: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650
Score = 35.8 bits (81), Expect = 0.12
Identities = 22/67 (32%), Positives = 35/67 (52%), Gaps = 8/67 (11%)
Query: 511 NALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTN 570
+A V LL+D GAEV+ D +G + L ++ Y + ++ L+E GA D T+
Sbjct: 727 HASVVSLLIDRGAEVDHCDKDGMTPL-LVAAYEGHV-------DVVDLLLEGGADVDHTD 778
Query: 571 KQNKTPL 577
+TPL
Sbjct: 779 NNGRTPL 785
Score = 33.1 bits (74), Expect = 0.79
Identities = 24/65 (36%), Positives = 35/65 (53%), Gaps = 5/65 (7%)
Query: 514 VTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIIS-LVEAGAHTDMTNKQ 572
+ + LLD GAEVN D +G +AL + P S H+ ++S L++ GA D +K
Sbjct: 692 IVEHLLDHGAEVNHEDVDGRTALS-VAALCVPASKG---HASVVSLLIDRGAEVDHCDKD 747
Query: 573 NKTPL 577
TPL
Sbjct: 748 GMTPL 752
Score = 31.6 bits (70), Expect = 2.3
Identities = 24/74 (32%), Positives = 34/74 (45%), Gaps = 3/74 (4%)
Query: 518 LLDCGAEVNAVDNEGNSALHIIVQY--NRPISDFLTLHSIIISLVEAGAHTDMTNKQNKT 575
LL GAEVN DNEG +AL I Y +R I + L H ++ + T ++
Sbjct: 663 LLQHGAEVNKADNEGRTAL-IAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCV 721
Query: 576 PLDKSTTGVSEILL 589
P K V +L+
Sbjct: 722 PASKGHASVVSLLI 735
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 103 bits (256), Expect = 6e-22
Identities = 68/203 (33%), Positives = 99/203 (48%), Gaps = 8/203 (3%)
Query: 39 VSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGA 98
VS QG PL AA GH +V+LL +Q G V + +DG T L AA
Sbjct: 563 VSLQGKDAWLPLHYAAWQGHLPIVKLL-------AKQPG-VSVNAQTLDGRTPLHLAAQR 614
Query: 99 GHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCL 158
GH+ V ++L+ ++VN ++ TPL A G + L+ A T L
Sbjct: 615 GHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTAL 674
Query: 159 MIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGH 218
+AA GH V+ L+E++AD A+ TALH AA GH ++V+EL+ + +
Sbjct: 675 HLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQ 734
Query: 219 GMTPLKVAAESCKADVVELLLSH 241
G++ L +AA+ A VE LL H
Sbjct: 735 GLSALHLAAQGRHAQTVETLLRH 757
Score = 77.8 bits (190), Expect = 3e-14
Identities = 71/237 (29%), Positives = 104/237 (43%), Gaps = 20/237 (8%)
Query: 5 AGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRL 64
A ++ A G+ LLLN + ++ G STPL +A VV L
Sbjct: 439 ASLLHLAVEAGQEECAKWLLLNNANPNLSNRRG---------STPLHMAVERRVRGVVEL 489
Query: 65 LLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTP 124
LL + + D TAL AA G +LL+ A+VN TP
Sbjct: 490 LLAR---------KISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTP 540
Query: 125 LRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQ-RADPNAK 183
+ AC G+ +IV+ L+ ++S+ K L AA++GH +V+ L +Q NA+
Sbjct: 541 MHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQ 600
Query: 184 AHCGATALHFAAEAGHIDIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLL 239
G T LH AA+ GH + + LI + + V + TPL VAAE+ LLL
Sbjct: 601 TLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLL 657
Score = 58.2 bits (139), Expect = 2e-08
Identities = 46/152 (30%), Positives = 69/152 (45%), Gaps = 1/152 (0%)
Query: 88 GATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANI 147
GA+ L A AG E K L+ + AN N + STPL A +V+ L+ ++
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
Query: 148 SIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELI 207
+ ++ T L AA G R LLE+ A N G T +H A + G +IV+ L+
Sbjct: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557
Query: 208 KWRAAIVVNG-HGMTPLKVAAESCKADVVELL 238
+ + + G PL AA +V+LL
Sbjct: 558 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL 589
Score = 37.7 bits (86), Expect = 0.032
Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 2/84 (2%)
Query: 158 LMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRA-AIVVN 216
L+ A G T + +L+ + D + GA+ LH A EAG + K L+ A + N
Sbjct: 410 LVDAIVSGDTSKLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSN 468
Query: 217 GHGMTPLKVAAESCKADVVELLLS 240
G TPL +A E VVELLL+
Sbjct: 469 RRGSTPLHMAVERRVRGVVELLLA 492
Score = 32.3 bits (72), Expect = 1.3
Identities = 24/95 (25%), Positives = 42/95 (44%), Gaps = 1/95 (1%)
Query: 146 NISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKE 205
++ +A + L +A G + ++LL A+PN G+T LH A E +V+
Sbjct: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
Query: 206 LIKWRAAIVVNGHGM-TPLKVAAESCKADVVELLL 239
L+ + ++ T L AA++ LLL
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLL 524
Score = 32.3 bits (72), Expect = 1.3
Identities = 19/63 (30%), Positives = 30/63 (47%), Gaps = 8/63 (12%)
Query: 515 TKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNK 574
T+LLL+ A VN VD EG + +H+ Q+ + +I+ L+ G + K
Sbjct: 520 TRLLLEKNASVNEVDFEGRTPMHVACQHGQ--------ENIVRILLRRGVDVSLQGKDAW 571
Query: 575 TPL 577
PL
Sbjct: 572 LPL 574
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 102 bits (254), Expect = 1e-21
Identities = 75/218 (34%), Positives = 105/218 (48%), Gaps = 26/218 (11%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRF-------DGYVI-------------- 86
TPL+ AA GH K+V+LLL H Q+ T GYV
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 87 ---DGATALWCAAGAGHFEVVKLLVSHGANVN-HTTVTNSTPLRAACFDGRLDIVKYLVE 142
+G T L A AGH EV +LL+ +GA +N H+ + L AC+ G L++V++L+E
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 143 NNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDI 202
A+ +T LM A GH +V R LL+ A N A + L AA GH+++
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
Query: 203 VKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLL 239
LI+ A++ VN G TPL AA ++V LLL
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL 520
Score = 100 bits (248), Expect = 5e-21
Identities = 96/301 (31%), Positives = 141/301 (46%), Gaps = 33/301 (10%)
Query: 11 AASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYR 70
A S G+ + LL + + R + Y TPL +AA G+ ++++LL
Sbjct: 1157 ACSGGRQEVVELLLARGANKEHRNVSDY---------TPLSLAASGGYVNIIKILLNAGA 1207
Query: 71 VQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTN-STPLRAAC 129
+TG+ G + L AA GH VKLL+ G+++N TN +T L AC
Sbjct: 1208 EINSRTGSKL-------GISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1260
Query: 130 FDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGA- 188
F GR ++V L++ AN+ K T LM AA G+ +V R LL++ AD NA +
Sbjct: 1261 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1320
Query: 189 -TALHFAAEAGHIDIVKELIKWRAAIVV-NGHGMTPLKVAAESCKADVVELLL-SHADCD 245
TAL AA+ GH + LI A I V N G TPL +AA DVV+LL+ + AD D
Sbjct: 1321 DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD 1380
Query: 246 RRSRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGD------NILEKEVLPPI 299
+ L+ A R+ + +K YL + + D + I +KE+L
Sbjct: 1381 AADNRKITPLMAAF----RKGH--VKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKC 1434
Query: 300 H 300
H
Sbjct: 1435 H 1435
Score = 90.9 bits (224), Expect = 3e-18
Identities = 70/199 (35%), Positives = 102/199 (51%), Gaps = 18/199 (9%)
Query: 48 TPLIIAARNGHAKVVRLLLEH---YRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVV 104
TPLI+AA GH VV +LL++ Q+++T T L A G EVV
Sbjct: 1118 TPLILAATAGHVGVVEILLDNGADIEAQSERTKD-----------TPLSLACSGGRQEVV 1166
Query: 105 KLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANIS--IANKYDNTCLMIAA 162
+LL++ GAN H V++ TPL A G ++I+K L+ A I+ +K + LM+AA
Sbjct: 1167 ELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAA 1226
Query: 163 YKGHTDVVRYLLEQRADPNAKAHCGA-TALHFAAEAGHIDIVKELIKWRAAIVVNGH-GM 220
GHT V+ LL+ +D NA+ TAL A G ++V L+ +A + G+
Sbjct: 1227 MNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGL 1286
Query: 221 TPLKVAAESCKADVVELLL 239
TPL AA A+V +LL
Sbjct: 1287 TPLMEAASGGYAEVGRVLL 1305
Score = 89.0 bits (219), Expect = 1e-17
Identities = 83/254 (32%), Positives = 122/254 (48%), Gaps = 32/254 (12%)
Query: 12 ASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLL---EH 68
A+ G + LAALL+ R S L V+ +G TPL+ AAR GH ++V LLL +
Sbjct: 474 AACGGHVELAALLIERGAS-----LEEVNDEG---YTPLMEAAREGHEEMVALLLGQGAN 525
Query: 69 YRVQTQQT-----------GTVRFDGYVIDG--------ATALWCAAGAGHFEVVKLLVS 109
QT++T G + ++I +T L AA GH E+VK L++
Sbjct: 526 INAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLA 585
Query: 110 HGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDV 169
GANV+ TT T T L AC +G D+ L++ A++ ++ T LM AA GH
Sbjct: 586 AGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCT 645
Query: 170 VRYLLEQRADPN-AKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVN-GHGMTPLKVAA 227
V++L+ + A+ N A+ T L A GH+ +V+ L+ A G T L AA
Sbjct: 646 VQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 705
Query: 228 ESCKADVVELLLSH 241
+ VV LL +
Sbjct: 706 KGGHTSVVCYLLDY 719
Score = 85.5 bits (210), Expect = 1e-16
Identities = 64/201 (31%), Positives = 103/201 (51%), Gaps = 20/201 (9%)
Query: 10 KAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE-H 68
+A SEG V + LL+ V++ + + L +A G+ ++ ++LL H
Sbjct: 240 EACSEGDVNAVRKLLIEGRS---------VNEHTEEGESLLCLACSAGYYELAQVLLAMH 290
Query: 69 YRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAA 128
V+ D + T L AA GH ++VKLL++H A+VN + T +T L A
Sbjct: 291 ANVE---------DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341
Query: 129 CFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAH-CG 187
C G +D+VK L+E+ A+I N+ +T LM A GH +V R LLE A N ++
Sbjct: 342 CAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK 401
Query: 188 ATALHFAAEAGHIDIVKELIK 208
+AL A GH+++V+ L++
Sbjct: 402 ESALTLACYKGHLEMVRFLLE 422
Score = 82.0 bits (201), Expect = 1e-15
Identities = 65/196 (33%), Positives = 96/196 (48%), Gaps = 12/196 (6%)
Query: 46 RSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVK 105
+ + L +A GH ++VR LLE Q +T + TAL A GH EV +
Sbjct: 401 KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMH---------TALMEACMDGHVEVAR 451
Query: 106 LLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKG 165
LL+ GA VN + +PL A G +++ L+E A++ N T LM AA +G
Sbjct: 452 LLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREG 511
Query: 166 HTDVVRYLLEQRADPNAKA-HCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLK 224
H ++V LL Q A+ NA+ TAL A G +++ LIK A I + TPL
Sbjct: 512 HEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELG--CSTPLM 569
Query: 225 VAAESCKADVVELLLS 240
AA+ ++V+ LL+
Sbjct: 570 EAAQEGHLELVKYLLA 585
Score = 82.0 bits (201), Expect = 1e-15
Identities = 67/217 (30%), Positives = 105/217 (48%), Gaps = 19/217 (8%)
Query: 40 SQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAG 99
+Q T L +A GH ++V+ LLE + G T L AA AG
Sbjct: 1077 AQTESNHDTALTLACAGGHEELVQTLLER---------GASIEHRDKKGFTPLILAATAG 1127
Query: 100 HFEVVKLLVSHGANVN-HTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCL 158
H VV++L+ +GA++ + T TPL AC GR ++V+ L+ AN N D T L
Sbjct: 1128 HVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL 1187
Query: 159 MIAAYKGHTDVVRYLLEQRADPNAK--AHCGATALHFAAEAGHIDIVKELIKWRAAI--V 214
+AA G+ ++++ LL A+ N++ + G + L AA GH VK L+ + I
Sbjct: 1188 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ 1247
Query: 215 VNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIE 251
+ + T L +A + +VV LLL DR++ +E
Sbjct: 1248 IETNRNTALTLACFQGRTEVVSLLL-----DRKANVE 1279
Score = 72.8 bits (177), Expect = 9e-13
Identities = 66/236 (27%), Positives = 105/236 (44%), Gaps = 21/236 (8%)
Query: 21 AALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVR 80
AAL R+ES + G + L A G VR LL R + T
Sbjct: 217 AALTRMRAES--------TANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTE--- 265
Query: 81 FDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNS-TPLRAACFDGRLDIVKY 139
+G + L A AG++E+ ++L++ ANV + TPL AA G + IVK
Sbjct: 266 ------EGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKL 319
Query: 140 LVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGH 199
L+ + A+++ + NT L A G+ DVV+ LLE A G T L A AGH
Sbjct: 320 LLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGH 379
Query: 200 IDIVKELIKWRAAIVVNGHGM--TPLKVAAESCKADVVELLLSHADCDRRSRIEAL 253
+++ + L++ A I + + + L +A ++V LL A D+ + + +
Sbjct: 380 VEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL-EAGADQEHKTDEM 434
Score = 50.4 bits (119), Expect = 5e-06
Identities = 39/117 (33%), Positives = 54/117 (46%), Gaps = 10/117 (8%)
Query: 42 QGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHF 101
+GG+ TPL+ AAR GH V+ L+ + T + T L A GH
Sbjct: 628 EGGR--TPLMKAARAGHVCTVQFLISKGANVNRTTAN--------NDHTVLSLACAGGHL 677
Query: 102 EVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCL 158
VV+LL++HGA+ H ST L A G +V YL++ N+ A D T L
Sbjct: 678 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQL 734
Score = 33.1 bits (74), Expect = 0.79
Identities = 23/72 (31%), Positives = 35/72 (48%), Gaps = 6/72 (8%)
Query: 512 ALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNK 571
A V ++LLD GA+VNA + + + ++ F L L+ GAH D+ NK
Sbjct: 1298 AEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL------LIGRGAHIDVRNK 1351
Query: 572 QNKTPLDKSTTG 583
+ TPL + G
Sbjct: 1352 KGNTPLWLAANG 1363
Score = 31.6 bits (70), Expect = 2.3
Identities = 26/93 (27%), Positives = 40/93 (43%), Gaps = 10/93 (10%)
Query: 487 LLHLAVNSNTPVDDFHTN--DVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNR 544
LL + D+ HT + C + V +LLLD GA+VN + S L +
Sbjct: 420 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA---- 475
Query: 545 PISDFLTLHSIIISLVEAGAHTDMTNKQNKTPL 577
+ L ++ L+E GA + N + TPL
Sbjct: 476 -CGGHVELAAL---LIERGASLEEVNDEGYTPL 504
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 102 bits (254), Expect = 1e-21
Identities = 75/218 (34%), Positives = 105/218 (48%), Gaps = 26/218 (11%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRF-------DGYVI-------------- 86
TPL+ AA GH K+V+LLL H Q+ T GYV
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 87 ---DGATALWCAAGAGHFEVVKLLVSHGANVN-HTTVTNSTPLRAACFDGRLDIVKYLVE 142
+G T L A AGH EV +LL+ +GA +N H+ + L AC+ G L++V++L+E
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 143 NNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDI 202
A+ +T LM A GH +V R LL+ A N A + L AA GH+++
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
Query: 203 VKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLL 239
LI+ A++ VN G TPL AA ++V LLL
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL 520
Score = 100 bits (248), Expect = 5e-21
Identities = 96/301 (31%), Positives = 141/301 (46%), Gaps = 33/301 (10%)
Query: 11 AASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYR 70
A S G+ + LL + + R + Y TPL +AA G+ ++++LL
Sbjct: 906 ACSGGRQEVVELLLARGANKEHRNVSDY---------TPLSLAASGGYVNIIKILLNAGA 956
Query: 71 VQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTN-STPLRAAC 129
+TG+ G + L AA GH VKLL+ G+++N TN +T L AC
Sbjct: 957 EINSRTGSKL-------GISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009
Query: 130 FDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGA- 188
F GR ++V L++ AN+ K T LM AA G+ +V R LL++ AD NA +
Sbjct: 1010 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1069
Query: 189 -TALHFAAEAGHIDIVKELIKWRAAIVV-NGHGMTPLKVAAESCKADVVELLL-SHADCD 245
TAL AA+ GH + LI A I V N G TPL +AA DVV+LL+ + AD D
Sbjct: 1070 DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD 1129
Query: 246 RRSRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGD------NILEKEVLPPI 299
+ L+ A R+ + +K YL + + D + I +KE+L
Sbjct: 1130 AADNRKITPLMAAF----RKGH--VKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKC 1183
Query: 300 H 300
H
Sbjct: 1184 H 1184
Score = 90.9 bits (224), Expect = 3e-18
Identities = 70/199 (35%), Positives = 102/199 (51%), Gaps = 18/199 (9%)
Query: 48 TPLIIAARNGHAKVVRLLLEH---YRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVV 104
TPLI+AA GH VV +LL++ Q+++T T L A G EVV
Sbjct: 867 TPLILAATAGHVGVVEILLDNGADIEAQSERTKD-----------TPLSLACSGGRQEVV 915
Query: 105 KLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANIS--IANKYDNTCLMIAA 162
+LL++ GAN H V++ TPL A G ++I+K L+ A I+ +K + LM+AA
Sbjct: 916 ELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAA 975
Query: 163 YKGHTDVVRYLLEQRADPNAKAHCGA-TALHFAAEAGHIDIVKELIKWRAAIVVNGH-GM 220
GHT V+ LL+ +D NA+ TAL A G ++V L+ +A + G+
Sbjct: 976 MNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGL 1035
Query: 221 TPLKVAAESCKADVVELLL 239
TPL AA A+V +LL
Sbjct: 1036 TPLMEAASGGYAEVGRVLL 1054
Score = 89.0 bits (219), Expect = 1e-17
Identities = 83/254 (32%), Positives = 122/254 (48%), Gaps = 32/254 (12%)
Query: 12 ASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLL---EH 68
A+ G + LAALL+ R S L V+ +G TPL+ AAR GH ++V LLL +
Sbjct: 474 AACGGHVELAALLIERGAS-----LEEVNDEG---YTPLMEAAREGHEEMVALLLGQGAN 525
Query: 69 YRVQTQQT-----------GTVRFDGYVIDG--------ATALWCAAGAGHFEVVKLLVS 109
QT++T G + ++I +T L AA GH E+VK L++
Sbjct: 526 INAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLA 585
Query: 110 HGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDV 169
GANV+ TT T T L AC +G D+ L++ A++ ++ T LM AA GH
Sbjct: 586 AGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCT 645
Query: 170 VRYLLEQRADPN-AKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVN-GHGMTPLKVAA 227
V++L+ + A+ N A+ T L A GH+ +V+ L+ A G T L AA
Sbjct: 646 VQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 705
Query: 228 ESCKADVVELLLSH 241
+ VV LL +
Sbjct: 706 KGGHTSVVCYLLDY 719
Score = 85.5 bits (210), Expect = 1e-16
Identities = 64/201 (31%), Positives = 103/201 (51%), Gaps = 20/201 (9%)
Query: 10 KAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE-H 68
+A SEG V + LL+ V++ + + L +A G+ ++ ++LL H
Sbjct: 240 EACSEGDVNAVRKLLIEGRS---------VNEHTEEGESLLCLACSAGYYELAQVLLAMH 290
Query: 69 YRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAA 128
V+ D + T L AA GH ++VKLL++H A+VN + T +T L A
Sbjct: 291 ANVE---------DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341
Query: 129 CFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAH-CG 187
C G +D+VK L+E+ A+I N+ +T LM A GH +V R LLE A N ++
Sbjct: 342 CAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK 401
Query: 188 ATALHFAAEAGHIDIVKELIK 208
+AL A GH+++V+ L++
Sbjct: 402 ESALTLACYKGHLEMVRFLLE 422
Score = 82.0 bits (201), Expect = 1e-15
Identities = 65/196 (33%), Positives = 96/196 (48%), Gaps = 12/196 (6%)
Query: 46 RSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVK 105
+ + L +A GH ++VR LLE Q +T + TAL A GH EV +
Sbjct: 401 KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMH---------TALMEACMDGHVEVAR 451
Query: 106 LLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKG 165
LL+ GA VN + +PL A G +++ L+E A++ N T LM AA +G
Sbjct: 452 LLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREG 511
Query: 166 HTDVVRYLLEQRADPNAKA-HCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLK 224
H ++V LL Q A+ NA+ TAL A G +++ LIK A I + TPL
Sbjct: 512 HEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELG--CSTPLM 569
Query: 225 VAAESCKADVVELLLS 240
AA+ ++V+ LL+
Sbjct: 570 EAAQEGHLELVKYLLA 585
Score = 82.0 bits (201), Expect = 1e-15
Identities = 67/217 (30%), Positives = 105/217 (48%), Gaps = 19/217 (8%)
Query: 40 SQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAG 99
+Q T L +A GH ++V+ LLE + G T L AA AG
Sbjct: 826 AQTESNHDTALTLACAGGHEELVQTLLER---------GASIEHRDKKGFTPLILAATAG 876
Query: 100 HFEVVKLLVSHGANVN-HTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCL 158
H VV++L+ +GA++ + T TPL AC GR ++V+ L+ AN N D T L
Sbjct: 877 HVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL 936
Query: 159 MIAAYKGHTDVVRYLLEQRADPNAK--AHCGATALHFAAEAGHIDIVKELIKWRAAI--V 214
+AA G+ ++++ LL A+ N++ + G + L AA GH VK L+ + I
Sbjct: 937 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQ 996
Query: 215 VNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIE 251
+ + T L +A + +VV LLL DR++ +E
Sbjct: 997 IETNRNTALTLACFQGRTEVVSLLL-----DRKANVE 1028
Score = 72.8 bits (177), Expect = 9e-13
Identities = 66/236 (27%), Positives = 105/236 (44%), Gaps = 21/236 (8%)
Query: 21 AALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVR 80
AAL R+ES + G + L A G VR LL R + T
Sbjct: 217 AALTRMRAES--------TANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTE--- 265
Query: 81 FDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNS-TPLRAACFDGRLDIVKY 139
+G + L A AG++E+ ++L++ ANV + TPL AA G + IVK
Sbjct: 266 ------EGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKL 319
Query: 140 LVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGH 199
L+ + A+++ + NT L A G+ DVV+ LLE A G T L A AGH
Sbjct: 320 LLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGH 379
Query: 200 IDIVKELIKWRAAIVVNGHGM--TPLKVAAESCKADVVELLLSHADCDRRSRIEAL 253
+++ + L++ A I + + + L +A ++V LL A D+ + + +
Sbjct: 380 VEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL-EAGADQEHKTDEM 434
Score = 50.4 bits (119), Expect = 5e-06
Identities = 39/117 (33%), Positives = 54/117 (46%), Gaps = 10/117 (8%)
Query: 42 QGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHF 101
+GG+ TPL+ AAR GH V+ L+ + T + T L A GH
Sbjct: 628 EGGR--TPLMKAARAGHVCTVQFLISKGANVNRTTAN--------NDHTVLSLACAGGHL 677
Query: 102 EVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCL 158
VV+LL++HGA+ H ST L A G +V YL++ N+ A D T L
Sbjct: 678 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQL 734
Score = 33.1 bits (74), Expect = 0.79
Identities = 23/72 (31%), Positives = 35/72 (48%), Gaps = 6/72 (8%)
Query: 512 ALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNK 571
A V ++LLD GA+VNA + + + ++ F L L+ GAH D+ NK
Sbjct: 1047 AEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL------LIGRGAHIDVRNK 1100
Query: 572 QNKTPLDKSTTG 583
+ TPL + G
Sbjct: 1101 KGNTPLWLAANG 1112
Score = 31.6 bits (70), Expect = 2.3
Identities = 26/93 (27%), Positives = 40/93 (43%), Gaps = 10/93 (10%)
Query: 487 LLHLAVNSNTPVDDFHTN--DVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNR 544
LL + D+ HT + C + V +LLLD GA+VN + S L +
Sbjct: 420 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA---- 475
Query: 545 PISDFLTLHSIIISLVEAGAHTDMTNKQNKTPL 577
+ L ++ L+E GA + N + TPL
Sbjct: 476 -CGGHVELAAL---LIERGASLEEVNDEGYTPL 504
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 96.7 bits (239), Expect = 6e-20
Identities = 81/267 (30%), Positives = 128/267 (47%), Gaps = 31/267 (11%)
Query: 50 LIIAARNGHAKVVRLLL---EHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKL 106
L AA GH+ VV+ LL + + V+ T T+ G TAL AAG G EV +L
Sbjct: 1037 LTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLW-------GETALTAAAGRGKLEVCEL 1089
Query: 107 LVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGH 166
L+ HGA V+ T PL A G IV+ L+E ++++++K T LM+AA +GH
Sbjct: 1090 LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGH 1149
Query: 167 TDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI-VVNGHGMTPLKV 225
V +LL + A ++ G +AL +A GH +V+ L++ AAI + +G TPL +
Sbjct: 1150 LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDL 1209
Query: 226 AAESCKADVVELL------LSHAD------------CDRRSRIEALELLGASFANDRENY 267
AA A+ V L + H D C S + AL GA N +
Sbjct: 1210 AAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGN--AAW 1267
Query: 268 DIIKTYHYLYLAMLERFQDGDNILEKE 294
+ + + + +L++ + N++ K+
Sbjct: 1268 AMATSKPDILIILLQKLMEEGNVMYKK 1294
Score = 74.3 bits (181), Expect = 3e-13
Identities = 64/201 (31%), Positives = 89/201 (44%), Gaps = 24/201 (11%)
Query: 11 AASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEH-- 68
AA GK L + LLL + VS+ + PL AAR GH ++VRLLLE
Sbjct: 1078 AAGRGK-LEVCELLLGHGAA--------VSRTNRRGVPPLFCAARQGHWQIVRLLLERGC 1128
Query: 69 -YRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
+ +Q G T L AA GH V+ L+S GA ++ + L
Sbjct: 1129 DVNLSDKQ------------GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSW 1176
Query: 128 ACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCG 187
AC G +V+YLVE A I +K T L +AA+ G + V YL+E+ A H G
Sbjct: 1177 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1236
Query: 188 ATALHFAAEAGHIDIVKELIK 208
L A + +V L++
Sbjct: 1237 MRPLDRAIGCRNTSVVVALLR 1257
Score = 67.8 bits (164), Expect = 3e-11
Identities = 55/176 (31%), Positives = 81/176 (46%), Gaps = 13/176 (7%)
Query: 79 VRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVK 138
V + V++ A L + GH EVV LL+ GA ++ T+ T L A G + +V
Sbjct: 918 VNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVC 977
Query: 139 YLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPN-------AKAHCGATAL 191
L + + +K L+ +A +GH D+++YLL P K+H AL
Sbjct: 978 LLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQAL 1037
Query: 192 HFAAEAGHIDIVKELI--KWRAAIVVNG----HGMTPLKVAAESCKADVVELLLSH 241
AA GH +V+ L+ + + VNG G T L AA K +V ELLL H
Sbjct: 1038 TAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGH 1093
Score = 64.3 bits (155), Expect = 3e-10
Identities = 65/211 (30%), Positives = 89/211 (42%), Gaps = 27/211 (12%)
Query: 50 LIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVS 109
L + + GH +VV LLLE DG +G TAL AA AGH ++V LL
Sbjct: 931 LCVQSHLGHEEVVTLLLEF---------GACLDGTSENGMTALCYAAAAGHMKLVCLLTK 981
Query: 110 HGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNT---------CLMI 160
G V+H L + G DI++YL+ S T L
Sbjct: 982 KGVRVDHLDKKGQCALVHSALRGHGDILQYLL--TCEWSPGPPQPGTLRKSHALQQALTA 1039
Query: 161 AAYKGHTDVVRYLLEQRADPNAKAH-----CGATALHFAAEAGHIDIVKELIKWRAAIV- 214
AA GH+ VV+ LL + + + G TAL AA G +++ + L+ AA+
Sbjct: 1040 AASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSR 1099
Query: 215 VNGHGMTPLKVAAESCKADVVELLLSHADCD 245
N G+ PL AA +V LLL CD
Sbjct: 1100 TNRRGVPPLFCAARQGHWQIVRLLLERG-CD 1129
Score = 34.7 bits (78), Expect = 0.27
Identities = 22/63 (34%), Positives = 32/63 (50%), Gaps = 8/63 (12%)
Query: 516 KLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKT 575
+ LL GA ++++D EG SAL +++ LVE GA D T+K +T
Sbjct: 1154 EFLLSKGAALSSLDKEGLSALSWACLKGH--------RAVVQYLVEEGAAIDQTDKNGRT 1205
Query: 576 PLD 578
PLD
Sbjct: 1206 PLD 1208
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 96.7 bits (239), Expect = 6e-20
Identities = 81/267 (30%), Positives = 128/267 (47%), Gaps = 31/267 (11%)
Query: 50 LIIAARNGHAKVVRLLL---EHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKL 106
L AA GH+ VV+ LL + + V+ T T+ G TAL AAG G EV +L
Sbjct: 1045 LTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLW-------GETALTAAAGRGKLEVCEL 1097
Query: 107 LVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGH 166
L+ HGA V+ T PL A G IV+ L+E ++++++K T LM+AA +GH
Sbjct: 1098 LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGH 1157
Query: 167 TDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI-VVNGHGMTPLKV 225
V +LL + A ++ G +AL +A GH +V+ L++ AAI + +G TPL +
Sbjct: 1158 LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDL 1217
Query: 226 AAESCKADVVELL------LSHAD------------CDRRSRIEALELLGASFANDRENY 267
AA A+ V L + H D C S + AL GA N +
Sbjct: 1218 AAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGN--AAW 1275
Query: 268 DIIKTYHYLYLAMLERFQDGDNILEKE 294
+ + + + +L++ + N++ K+
Sbjct: 1276 AMATSKPDILIILLQKLMEEGNVMYKK 1302
Score = 74.3 bits (181), Expect = 3e-13
Identities = 64/201 (31%), Positives = 89/201 (44%), Gaps = 24/201 (11%)
Query: 11 AASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEH-- 68
AA GK L + LLL + VS+ + PL AAR GH ++VRLLLE
Sbjct: 1086 AAGRGK-LEVCELLLGHGAA--------VSRTNRRGVPPLFCAARQGHWQIVRLLLERGC 1136
Query: 69 -YRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
+ +Q G T L AA GH V+ L+S GA ++ + L
Sbjct: 1137 DVNLSDKQ------------GRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSW 1184
Query: 128 ACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCG 187
AC G +V+YLVE A I +K T L +AA+ G + V YL+E+ A H G
Sbjct: 1185 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1244
Query: 188 ATALHFAAEAGHIDIVKELIK 208
L A + +V L++
Sbjct: 1245 MRPLDRAIGCRNTSVVVALLR 1265
Score = 67.8 bits (164), Expect = 3e-11
Identities = 55/176 (31%), Positives = 81/176 (46%), Gaps = 13/176 (7%)
Query: 79 VRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVK 138
V + V++ A L + GH EVV LL+ GA ++ T+ T L A G + +V
Sbjct: 926 VNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVC 985
Query: 139 YLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPN-------AKAHCGATAL 191
L + + +K L+ +A +GH D+++YLL P K+H AL
Sbjct: 986 LLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQAL 1045
Query: 192 HFAAEAGHIDIVKELI--KWRAAIVVNG----HGMTPLKVAAESCKADVVELLLSH 241
AA GH +V+ L+ + + VNG G T L AA K +V ELLL H
Sbjct: 1046 TAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGH 1101
Score = 64.3 bits (155), Expect = 3e-10
Identities = 65/211 (30%), Positives = 89/211 (42%), Gaps = 27/211 (12%)
Query: 50 LIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVS 109
L + + GH +VV LLLE DG +G TAL AA AGH ++V LL
Sbjct: 939 LCVQSHLGHEEVVTLLLEF---------GACLDGTSENGMTALCYAAAAGHMKLVCLLTK 989
Query: 110 HGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNT---------CLMI 160
G V+H L + G DI++YL+ S T L
Sbjct: 990 KGVRVDHLDKKGQCALVHSALRGHGDILQYLL--TCEWSPGPPQPGTLRKSHALQQALTA 1047
Query: 161 AAYKGHTDVVRYLLEQRADPNAKAH-----CGATALHFAAEAGHIDIVKELIKWRAAIV- 214
AA GH+ VV+ LL + + + G TAL AA G +++ + L+ AA+
Sbjct: 1048 AASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSR 1107
Query: 215 VNGHGMTPLKVAAESCKADVVELLLSHADCD 245
N G+ PL AA +V LLL CD
Sbjct: 1108 TNRRGVPPLFCAARQGHWQIVRLLLERG-CD 1137
Score = 34.7 bits (78), Expect = 0.27
Identities = 22/63 (34%), Positives = 32/63 (50%), Gaps = 8/63 (12%)
Query: 516 KLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKT 575
+ LL GA ++++D EG SAL +++ LVE GA D T+K +T
Sbjct: 1162 EFLLSKGAALSSLDKEGLSALSWACLKGH--------RAVVQYLVEEGAAIDQTDKNGRT 1213
Query: 576 PLD 578
PLD
Sbjct: 1214 PLD 1216
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 96.7 bits (239), Expect = 6e-20
Identities = 74/244 (30%), Positives = 118/244 (48%), Gaps = 20/244 (8%)
Query: 1 MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAK 60
+EG +++ AA +G L +L +S+ DI Y GG T L AA +GH
Sbjct: 320 LEGRTSFMW-AAGKGSDDVLRTMLSLKSDIDINMADKY----GG---TALHAAALSGHVS 371
Query: 61 VVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVT 120
V+LLLE+ Q T ++ T L+ A GH +V++ L+ GA V+
Sbjct: 372 TVKLLLEN-NAQVDATDVMKH--------TPLFRACEMGHKDVIQTLIKGGARVDLVDQD 422
Query: 121 NSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADP 180
+ L A G D+ + L+EN N ++ + T L AAY G+ + + L+E ADP
Sbjct: 423 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482
Query: 181 NAKAHCGATALHFAAEAGHIDIVKELIKWRA---AIVVNGHGMTPLKVAAESCKADVVEL 237
N + G TALH++ G++D +K L+ + A + N TPL A + +V++
Sbjct: 483 NIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQF 542
Query: 238 LLSH 241
+L H
Sbjct: 543 MLEH 546
Score = 88.2 bits (217), Expect = 2e-17
Identities = 67/225 (29%), Positives = 109/225 (48%), Gaps = 27/225 (12%)
Query: 45 QRSTPLIIAARNGHAKVVRLLLEHYRVQTQQT--GTVRF--------------------- 81
Q +TPL AA++ A+ V++ L+H V+ G F
Sbjct: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347
Query: 82 -DGYVID--GATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVK 138
D + D G TAL AA +GH VKLL+ + A V+ T V TPL AC G D+++
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407
Query: 139 YLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAG 198
L++ A + + ++ ++ L AA G+ DV + L+E + +PN + + G T L AA G
Sbjct: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467
Query: 199 HIDIVKELIKWRA-AIVVNGHGMTPLKVAAESCKADVVELLLSHA 242
+I+ + L++ A + + G T L + + D ++LLL A
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFA 512
Score = 87.4 bits (215), Expect = 4e-17
Identities = 66/197 (33%), Positives = 103/197 (52%), Gaps = 11/197 (5%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL AA GHA++V LLLE ++GT+ D GAT L AA + E VK+
Sbjct: 257 TPLHWAALLGHAQIVHLLLER-----NKSGTIPSDS---QGATPLHYAAQSNFAETVKVF 308
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYL--VENNANISIANKYDNTCLMIAAYKG 165
+ H + + + + T A G D+++ + ++++ +I++A+KY T L AA G
Sbjct: 309 LKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSG 368
Query: 166 HTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI-VVNGHGMTPLK 224
H V+ LLE A +A T L A E GH D+++ LIK A + +V+ G + L
Sbjct: 369 HVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLH 428
Query: 225 VAAESCKADVVELLLSH 241
AA ADV ++L+ +
Sbjct: 429 WAALGGNADVCQILIEN 445
Score = 53.1 bits (126), Expect = 7e-07
Identities = 62/223 (27%), Positives = 94/223 (42%), Gaps = 22/223 (9%)
Query: 41 QQGGQRSTPLIIAARNGHAKVVRLLLEHY---RVQTQQTGTVRFDGYVIDGATALWCAAG 97
Q+ + TPL + R+ K + LLL+ V TQ TAL +A
Sbjct: 109 QKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNK----------QTALHWSAY 158
Query: 98 AGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFD---GRLDIVKYLVENNANISIANKYD 154
+ E VKLL+ H +N+ V PL A + V+ +++ S+ N D
Sbjct: 159 YNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQD 218
Query: 155 ---NTCLMIAAYKGHTDVVRYLLE-QRADPNAKAHCGATALHFAAEAGHIDIVKELIKWR 210
T L A G+ VV L + + + + T LH+AA GH IV L++
Sbjct: 219 YEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERN 278
Query: 211 AA--IVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIE 251
+ I + G TPL AA+S A+ V++ L H S +E
Sbjct: 279 KSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLE 321
Score = 43.9 bits (102), Expect = 4e-04
Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 18/197 (9%)
Query: 138 KYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEA 197
+ +V N+A +++ T LM D LL+ AD N H TALH AA+
Sbjct: 32 RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQK 91
Query: 198 GHIDIVKELIKWRAAIVVNG-HGMTPLKVAAESCKADVVELLL---SHADCDRRSRIEAL 253
G+ +K L+ RA + MTPL + + LLL + + D + + +
Sbjct: 92 GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQT 151
Query: 254 ELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQE 313
L +++ N+ E ++ +L + I + E P+H N ++P
Sbjct: 152 ALHWSAYYNNPE-----------HVKLLIKHDSNIGIPDVEGKIPLHWAANH---KDPSA 197
Query: 314 LESIRQDRDALHMEGLI 330
+ ++R DA E L+
Sbjct: 198 VHTVRCILDAAPTESLL 214
Score = 40.0 bits (92), Expect = 0.006
Identities = 41/170 (24%), Positives = 69/170 (40%), Gaps = 19/170 (11%)
Query: 90 TALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNA--NI 147
TAL AA G++ +KLL++ AN + TPL + L++ A +
Sbjct: 83 TALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEV 142
Query: 148 SIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIV---- 203
+K T L +AY + + V+ L++ ++ G LH+AA V
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVR 202
Query: 204 --------KELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCD 245
+ L+ W+ + G TPL A VV++L S+ C+
Sbjct: 203 CILDAAPTESLLNWQ-----DYEGRTPLHFAVADGNVTVVDVLTSYESCN 247
Score = 37.0 bits (84), Expect = 0.055
Identities = 36/140 (25%), Positives = 61/140 (43%), Gaps = 3/140 (2%)
Query: 105 KLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYK 164
+L+V + A + TPL RLD L++ A+++ + T L +AA K
Sbjct: 32 RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQK 91
Query: 165 GHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVV---NGHGMT 221
G+ ++ LL +RA+ K T LH + L+K+ A V + + T
Sbjct: 92 GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQT 151
Query: 222 PLKVAAESCKADVVELLLSH 241
L +A + V+LL+ H
Sbjct: 152 ALHWSAYYNNPEHVKLLIKH 171
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 96.7 bits (239), Expect = 6e-20
Identities = 74/244 (30%), Positives = 118/244 (48%), Gaps = 20/244 (8%)
Query: 1 MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAK 60
+EG +++ AA +G L +L +S+ DI Y GG T L AA +GH
Sbjct: 320 LEGRTSFMW-AAGKGSDDVLRTMLSLKSDIDINMADKY----GG---TALHAAALSGHVS 371
Query: 61 VVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVT 120
V+LLLE+ Q T ++ T L+ A GH +V++ L+ GA V+
Sbjct: 372 TVKLLLEN-NAQVDATDVMKH--------TPLFRACEMGHKDVIQTLIKGGARVDLVDQD 422
Query: 121 NSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADP 180
+ L A G D+ + L+EN N ++ + T L AAY G+ + + L+E ADP
Sbjct: 423 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482
Query: 181 NAKAHCGATALHFAAEAGHIDIVKELIKWRA---AIVVNGHGMTPLKVAAESCKADVVEL 237
N + G TALH++ G++D +K L+ + A + N TPL A + +V++
Sbjct: 483 NIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQF 542
Query: 238 LLSH 241
+L H
Sbjct: 543 MLEH 546
Score = 88.2 bits (217), Expect = 2e-17
Identities = 67/225 (29%), Positives = 109/225 (48%), Gaps = 27/225 (12%)
Query: 45 QRSTPLIIAARNGHAKVVRLLLEHYRVQTQQT--GTVRF--------------------- 81
Q +TPL AA++ A+ V++ L+H V+ G F
Sbjct: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347
Query: 82 -DGYVID--GATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVK 138
D + D G TAL AA +GH VKLL+ + A V+ T V TPL AC G D+++
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407
Query: 139 YLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAG 198
L++ A + + ++ ++ L AA G+ DV + L+E + +PN + + G T L AA G
Sbjct: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467
Query: 199 HIDIVKELIKWRA-AIVVNGHGMTPLKVAAESCKADVVELLLSHA 242
+I+ + L++ A + + G T L + + D ++LLL A
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFA 512
Score = 87.4 bits (215), Expect = 4e-17
Identities = 66/197 (33%), Positives = 103/197 (52%), Gaps = 11/197 (5%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL AA GHA++V LLLE ++GT+ D GAT L AA + E VK+
Sbjct: 257 TPLHWAALLGHAQIVHLLLER-----NKSGTIPSDS---QGATPLHYAAQSNFAETVKVF 308
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYL--VENNANISIANKYDNTCLMIAAYKG 165
+ H + + + + T A G D+++ + ++++ +I++A+KY T L AA G
Sbjct: 309 LKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSG 368
Query: 166 HTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI-VVNGHGMTPLK 224
H V+ LLE A +A T L A E GH D+++ LIK A + +V+ G + L
Sbjct: 369 HVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLH 428
Query: 225 VAAESCKADVVELLLSH 241
AA ADV ++L+ +
Sbjct: 429 WAALGGNADVCQILIEN 445
Score = 53.1 bits (126), Expect = 7e-07
Identities = 62/223 (27%), Positives = 94/223 (42%), Gaps = 22/223 (9%)
Query: 41 QQGGQRSTPLIIAARNGHAKVVRLLLEHY---RVQTQQTGTVRFDGYVIDGATALWCAAG 97
Q+ + TPL + R+ K + LLL+ V TQ TAL +A
Sbjct: 109 QKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNK----------QTALHWSAY 158
Query: 98 AGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFD---GRLDIVKYLVENNANISIANKYD 154
+ E VKLL+ H +N+ V PL A + V+ +++ S+ N D
Sbjct: 159 YNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQD 218
Query: 155 ---NTCLMIAAYKGHTDVVRYLLE-QRADPNAKAHCGATALHFAAEAGHIDIVKELIKWR 210
T L A G+ VV L + + + + T LH+AA GH IV L++
Sbjct: 219 YEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERN 278
Query: 211 AA--IVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIE 251
+ I + G TPL AA+S A+ V++ L H S +E
Sbjct: 279 KSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLE 321
Score = 43.9 bits (102), Expect = 4e-04
Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 18/197 (9%)
Query: 138 KYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEA 197
+ +V N+A +++ T LM D LL+ AD N H TALH AA+
Sbjct: 32 RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQK 91
Query: 198 GHIDIVKELIKWRAAIVVNG-HGMTPLKVAAESCKADVVELLL---SHADCDRRSRIEAL 253
G+ +K L+ RA + MTPL + + LLL + + D + + +
Sbjct: 92 GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQT 151
Query: 254 ELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQE 313
L +++ N+ E ++ +L + I + E P+H N ++P
Sbjct: 152 ALHWSAYYNNPE-----------HVKLLIKHDSNIGIPDVEGKIPLHWAANH---KDPSA 197
Query: 314 LESIRQDRDALHMEGLI 330
+ ++R DA E L+
Sbjct: 198 VHTVRCILDAAPTESLL 214
Score = 40.0 bits (92), Expect = 0.006
Identities = 41/170 (24%), Positives = 69/170 (40%), Gaps = 19/170 (11%)
Query: 90 TALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNA--NI 147
TAL AA G++ +KLL++ AN + TPL + L++ A +
Sbjct: 83 TALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEV 142
Query: 148 SIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIV---- 203
+K T L +AY + + V+ L++ ++ G LH+AA V
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVR 202
Query: 204 --------KELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCD 245
+ L+ W+ + G TPL A VV++L S+ C+
Sbjct: 203 CILDAAPTESLLNWQ-----DYEGRTPLHFAVADGNVTVVDVLTSYESCN 247
Score = 37.0 bits (84), Expect = 0.055
Identities = 36/140 (25%), Positives = 61/140 (43%), Gaps = 3/140 (2%)
Query: 105 KLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYK 164
+L+V + A + TPL RLD L++ A+++ + T L +AA K
Sbjct: 32 RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQK 91
Query: 165 GHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVV---NGHGMT 221
G+ ++ LL +RA+ K T LH + L+K+ A V + + T
Sbjct: 92 GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQT 151
Query: 222 PLKVAAESCKADVVELLLSH 241
L +A + V+LL+ H
Sbjct: 152 ALHWSAYYNNPEHVKLLIKH 171
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 96.3 bits (238), Expect = 8e-20
Identities = 71/191 (37%), Positives = 96/191 (50%), Gaps = 13/191 (6%)
Query: 39 VSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGA 98
VS + G+ T L AA +GH ++V+LLL + + A+ AA
Sbjct: 135 VSDRAGR--TALHHAAFSGHGEMVKLLLSR---------GANINAFDKKDRRAIHWAAYM 183
Query: 99 GHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCL 158
GH EVVKLLVSHGA V + TPL AA G + +VKYL++ +++ N Y NT L
Sbjct: 184 GHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPL 243
Query: 159 MIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIV--VN 216
+A Y G VV L++ A N K G T LHFAA + H + EL+ A V +
Sbjct: 244 HVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKS 303
Query: 217 GHGMTPLKVAA 227
G TPL + A
Sbjct: 304 KDGKTPLHMTA 314
Score = 84.3 bits (207), Expect = 3e-16
Identities = 68/226 (30%), Positives = 111/226 (49%), Gaps = 15/226 (6%)
Query: 19 TLAALLLNRSESDIRYLLGY---VSQQGGQRSTPLIIAARNGHAKVVRLL-LEHYRVQTQ 74
+L + N ++R L+ V+ Q ++ TPL AA G A+++ LL L RV +
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 75 QTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRL 134
+ + T L A + E V++L+ H A+VN TPL A + +
Sbjct: 71 DSKWL----------TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAV 120
Query: 135 DIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFA 194
+ LV +N++++++ T L AA+ GH ++V+ LL + A+ NA A+H+A
Sbjct: 121 KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWA 180
Query: 195 AEAGHIDIVKELIKWRAAIVV-NGHGMTPLKVAAESCKADVVELLL 239
A GHI++VK L+ A + + TPL AA S VV+ LL
Sbjct: 181 AYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLL 226
Score = 80.9 bits (198), Expect = 3e-15
Identities = 72/266 (27%), Positives = 116/266 (43%), Gaps = 26/266 (9%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
++ AA G L L+ + + D+R G TPL +AA GH + V +L+
Sbjct: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSG---------RTPLDLAAFKGHVECVDVLIN 604
Query: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNS---TP 124
Q ++ Y++ T + AA GH E ++LL+ + N + + TP
Sbjct: 605 -------QGASILVKDYILK-RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTP 656
Query: 125 LRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKA 184
L + +G D V L+ AN+ +K+ T L A GH + V LL+ A +
Sbjct: 657 LMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRD 716
Query: 185 HCGATALHFAAEAGHIDIVKELIKWRAAIVVN-----GHGMTPLKVAAESCKADVVELLL 239
G T +H +A GHI ++ L++ A++ N HG T L A + VELLL
Sbjct: 717 SRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLL 776
Query: 240 SHADCDRRSRIEALELLGASFANDRE 265
+ +++ A L + ND E
Sbjct: 777 EQ-EVFQKTEGNAFSPLHCAVINDNE 801
Score = 77.0 bits (188), Expect = 5e-14
Identities = 79/267 (29%), Positives = 114/267 (42%), Gaps = 42/267 (15%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
++ +A+ G + L ALL + + D + T L A NGH V LLLE
Sbjct: 723 IHLSAACGHIGVLGALLQSAASMDAN-----PATADNHGYTALHWACYNGHETCVELLLE 777
Query: 68 ---------------HYRVQTQQTGTVRFDGYVID-------------GATALWCAAGAG 99
H V G +ID G T L AA
Sbjct: 778 QEVFQKTEGNAFSPLHCAVINDNEGAAEM---LIDTLGASIVNATDSKGRTPLHAAAFTD 834
Query: 100 HFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVEN-NANISIANKYDNTCL 158
H E ++LL+SH A VN T TPL A +G+ + V+ LV + +A +++ + NT L
Sbjct: 835 HVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTAL 894
Query: 159 MIAAYKGHTDVVRYLLEQRADPNAKAHCGA---TALHFAAEAGHIDIVKELI-KWRAAIV 214
+A KGH +LE+ D N A T LH AA G +V+EL+ K + +
Sbjct: 895 HLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLA 954
Query: 215 VNGHGMTP-LKVAAESCKADVVELLLS 240
V+ +G TP L A AD + L+L+
Sbjct: 955 VDENGYTPALACAPNKDVADCLALILA 981
Score = 76.6 bits (187), Expect = 6e-14
Identities = 76/277 (27%), Positives = 114/277 (41%), Gaps = 54/277 (19%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
++ AA+ G L L+ N + V Q G TPL+++ NGH V LL
Sbjct: 621 IHAAATNGHSECLRLLIGNAEPQNA------VDIQDGNGQTPLMLSVLNGHTDCVYSLLN 674
Query: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
D G TAL A GH E V L+ HGA TP+
Sbjct: 675 K---------GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHL 725
Query: 128 ACFDGRLDIVKYLVEN----NANISIANKYDNTCLMIAAYKGHTDVVRYLLEQ----RAD 179
+ G + ++ L+++ +AN + A+ + T L A Y GH V LLEQ + +
Sbjct: 726 SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTE 785
Query: 180 PNAKA--HC----------------------------GATALHFAAEAGHIDIVKELIKW 209
NA + HC G T LH AA H++ ++ L+
Sbjct: 786 GNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSH 845
Query: 210 RAAI-VVNGHGMTPLKVAAESCKADVVELLLSHADCD 245
A + V+ G TPL +AAE+ + + VE+L+S A +
Sbjct: 846 NAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAE 882
Score = 71.2 bits (173), Expect = 3e-12
Identities = 65/226 (28%), Positives = 105/226 (46%), Gaps = 15/226 (6%)
Query: 30 SDIRYLLGY---VSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVI 86
S ++YLL +++ +TPL +A NG VV L++ + Q+
Sbjct: 220 SVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEK-------- 271
Query: 87 DGATALWCAAGAGHFEV-VKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNA 145
G T L AA + H + ++LLV +GA+VN + TPL GR + ++++ A
Sbjct: 272 -GFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGA 330
Query: 146 NISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKE 205
I +K NT L IAA GH ++ L+ AD + G LH AA +G D ++
Sbjct: 331 VIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRK 390
Query: 206 LIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLL-SHADCDRRSR 249
L+ I + G T L AA + + LLL + AD +++ +
Sbjct: 391 LLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDK 436
Score = 62.8 bits (151), Expect = 9e-10
Identities = 62/229 (27%), Positives = 102/229 (44%), Gaps = 19/229 (8%)
Query: 2 EGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKV 61
+G + AAS L L L+ N ++ +++ S+ G TPL + A +G
Sbjct: 271 KGFTPLHFAAASTHGALCLELLVGNGADVNMK------SKDG---KTPLHMTALHGRFSR 321
Query: 62 VRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTN 121
+ ++ Q+G V D +G T L AA GH ++ L++ GA+ +
Sbjct: 322 SQTII--------QSGAV-IDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHG 372
Query: 122 STPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPN 181
PL A G D + L+ + +I + + TCL AA G+ + + LL AD N
Sbjct: 373 MFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN 432
Query: 182 AKAHCGATALHFAAEAGHIDIVKELIKWRAAI-VVNGHGMTPLKVAAES 229
K G + LH+AA + + L+ A++ ++ G TPL AA S
Sbjct: 433 KKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATS 481
Score = 54.3 bits (129), Expect = 3e-07
Identities = 64/236 (27%), Positives = 98/236 (41%), Gaps = 46/236 (19%)
Query: 47 STPLIIAARNGHAKVVRLLLEHYRVQTQQTGT--------------------VRFDGYVI 86
+TPL IAAR GH ++ L+ T + G + G+ I
Sbjct: 340 NTPLHIAARYGHELLINTLITS-GADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDI 398
Query: 87 D-----GATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLV 141
D G T L AA G+ E + LL++ GA+ N +PL A + + LV
Sbjct: 399 DTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALV 458
Query: 142 ENNANISIANKYDNTCLMIAAYKGHTD--VVRYLLEQRADPNAKAHCGATALHFAAEAGH 199
+ A+++ ++ T L AA TD + YLL A+P + G A+H++A GH
Sbjct: 459 GSGASVNDLDERGCTPLHYAA-TSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH 517
Query: 200 IDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALEL 255
+ +LI TPL V E+ D++ +D D R+ I L L
Sbjct: 518 -RLCLQLIA----------SETPLDVLMETSGTDML------SDSDNRATISPLHL 556
Score = 54.3 bits (129), Expect = 3e-07
Identities = 37/123 (30%), Positives = 62/123 (50%), Gaps = 5/123 (4%)
Query: 123 TPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNA 182
+PL A + G ++ LV++ ++ + N T L +AA+KGH + V L+ Q A
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
Query: 183 KAH-CGATALHFAAEAGHIDIVKELI----KWRAAIVVNGHGMTPLKVAAESCKADVVEL 237
K + T +H AA GH + ++ LI A + +G+G TPL ++ + D V
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671
Query: 238 LLS 240
LL+
Sbjct: 672 LLN 674
Score = 47.8 bits (112), Expect = 3e-05
Identities = 33/98 (33%), Positives = 51/98 (52%), Gaps = 2/98 (2%)
Query: 154 DNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI 213
D L+ A + G D VR L+ ++ D N + + T LH AA G +I++ LI A +
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
Query: 214 -VVNGHGMTPLKVAAESCKADVVELLLSH-ADCDRRSR 249
+ +TPL A SC + V++LL H AD + R +
Sbjct: 68 NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDK 105
Score = 38.9 bits (89), Expect = 0.014
Identities = 30/115 (26%), Positives = 50/115 (43%), Gaps = 22/115 (19%)
Query: 477 LDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSAL 536
++ + +GFT LH A S AL +LL+ GA+VN +G + L
Sbjct: 265 VNQKNEKGFTPLHFAAASTH--------------GALCLELLVGNGADVNMKSKDGKTPL 310
Query: 537 HIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDKSTTGVSEILLKT 591
H+ + R S +++++GA D +K TPL + E+L+ T
Sbjct: 311 HMTALHGR--------FSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINT 357
Score = 34.3 bits (77), Expect = 0.36
Identities = 30/95 (31%), Positives = 42/95 (44%), Gaps = 13/95 (13%)
Query: 487 LLHLAVNSNTPVDDFHT--NDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNR 544
LL L V+ N P +T + C +V L+DCGA VN + +G + LH
Sbjct: 225 LLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAA---- 280
Query: 545 PISDFLTLHSIII--SLVEAGAHTDMTNKQNKTPL 577
+ H + LV GA +M +K KTPL
Sbjct: 281 -----ASTHGALCLELLVGNGADVNMKSKDGKTPL 310
Score = 33.9 bits (76), Expect = 0.46
Identities = 18/64 (28%), Positives = 32/64 (50%), Gaps = 8/64 (12%)
Query: 514 VTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQN 573
V K LLD G ++N + GN+ LH+ + + ++ L++ GA + N++
Sbjct: 221 VVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDV--------VVNELIDCGAIVNQKNEKG 272
Query: 574 KTPL 577
TPL
Sbjct: 273 FTPL 276
Score = 32.0 bits (71), Expect = 1.8
Identities = 46/191 (24%), Positives = 76/191 (39%), Gaps = 36/191 (18%)
Query: 389 AQVFSQMIHLNETVKAPDIECV--LRCSVLEIEQSMNRVKNISDADVHNAMDNYECNLYT 446
A++ +I V A D + + L +V + +V ADV NA D N T
Sbjct: 54 AEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADV-NARDK---NWQT 109
Query: 447 FLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTPVDDFHTNDV 506
L++ + +C+E + L +++ R G T LH A S
Sbjct: 110 PLHIAAANKAVKCAEA-------LVPLLSNVNVSDRAGRTALHHAAFSG----------- 151
Query: 507 CSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHT 566
+ + KLLL GA +NA D + A+H + ++ ++ LV GA
Sbjct: 152 ----HGEMVKLLLSRGANINAFDKKDRRAIH--------WAAYMGHIEVVKLLVSHGAEV 199
Query: 567 DMTNKQNKTPL 577
+K++ TPL
Sbjct: 200 TCKDKKSYTPL 210
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 95.1 bits (235), Expect = 2e-19
Identities = 72/233 (30%), Positives = 110/233 (47%), Gaps = 19/233 (8%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
V E + L ALL + D R G TPL+IAA G+ ++V+ L++
Sbjct: 9 VINYVEEENIPALKALLEKCKDVDERNECG---------QTPLMIAAEQGNLEIVKELIK 59
Query: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
+ + +D TAL A+ GH +V+ L+ G N+ H + T L
Sbjct: 60 NGANCNLED---------LDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMW 110
Query: 128 ACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCG 187
AC+ GR D+V+ L+ + AN S+ Y ++ AA +GH D+V LL+ A N G
Sbjct: 111 ACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYG 170
Query: 188 ATALHFAAEAGHIDIVKELIKWRAAIVVNG-HGMTPLKVAAESCKADVVELLL 239
T L +AA GH++ VK L+ A + G + MT L VA + V+ +L
Sbjct: 171 TTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEIL 223
Score = 94.4 bits (233), Expect = 3e-19
Identities = 71/230 (30%), Positives = 117/230 (50%), Gaps = 19/230 (8%)
Query: 11 AASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYR 70
AA +G + + L+ N + ++ L + T LI A++ GH +V LL+
Sbjct: 45 AAEQGNLEIVKELIKNGANCNLEDLDNW---------TALISASKEGHVHIVEELLKC-- 93
Query: 71 VQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACF 130
V + + G TAL A G +VV+LL+SHGAN + T + + P+ A
Sbjct: 94 -------GVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAG 146
Query: 131 DGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATA 190
G DIV L++N A ++ ++KY T L+ AA KGH + V++LL AD + + TA
Sbjct: 147 RGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTA 206
Query: 191 LHFAAEAGHIDIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLL 239
L A + G+ VKE++K + + + G T L +A++ ++V+ LL
Sbjct: 207 LIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256
Score = 93.6 bits (231), Expect = 5e-19
Identities = 69/193 (35%), Positives = 100/193 (51%), Gaps = 12/193 (6%)
Query: 49 PLIIAARNGHAKVVRLLLEH-YRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
P+I AA GHA +V LLL++ +V D Y G T L AA GH E VK L
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGAKVNCS-------DKY---GTTPLVWAARKGHLECVKHL 189
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
++ GA+V+ + T L A G VK +++ N N+++ +K NT LMIA+ +GHT
Sbjct: 190 LAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHT 249
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGH-GMTPLKVA 226
++V+ LL+ N G T L A GH++IV+ L++ A I + G T L A
Sbjct: 250 EIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWA 309
Query: 227 AESCKADVVELLL 239
E A +V +L
Sbjct: 310 VEKGNATMVRDIL 322
Score = 89.0 bits (219), Expect = 1e-17
Identities = 70/236 (29%), Positives = 118/236 (50%), Gaps = 19/236 (8%)
Query: 27 RSESDIRYLL----GYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFD 82
R +DI +LL V+ +TPL+ AAR GH + V+ LL Q G
Sbjct: 147 RGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLA-MGADVDQEGA---- 201
Query: 83 GYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVE 142
+ TAL A G+ + VK ++ NVN T +T L A +G +IV+ L++
Sbjct: 202 ----NSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLD 257
Query: 143 NNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDI 202
++I ++ +T L+ A GH ++VR LL++ AD + + TAL++A E G+ +
Sbjct: 258 AGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATM 317
Query: 203 VKELIKWRA-AIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLG 257
V+++++ + G TPL A + +VVELLL D+ +++ A++ G
Sbjct: 318 VRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLL-----DKGAKVSAVDKKG 368
Score = 57.0 bits (136), Expect = 5e-08
Identities = 39/106 (36%), Positives = 60/106 (56%), Gaps = 1/106 (0%)
Query: 137 VKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAE 196
+K L+E ++ N+ T LMIAA +G+ ++V+ L++ A+ N + TAL A++
Sbjct: 21 LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
Query: 197 AGHIDIVKELIKWRAAIVVNGHG-MTPLKVAAESCKADVVELLLSH 241
GH+ IV+EL+K + G T L A + DVVELLLSH
Sbjct: 81 EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSH 126
Score = 53.9 bits (128), Expect = 4e-07
Identities = 53/199 (26%), Positives = 88/199 (44%), Gaps = 21/199 (10%)
Query: 47 STPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVI----DGATALWCAAGAGHFE 102
+T L+IA++ GH ++V+ LL+ GT YV G T L A GH E
Sbjct: 237 NTALMIASKEGHTEIVQDLLD--------AGT-----YVNIPDRSGDTVLIGAVRGGHVE 283
Query: 103 VVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAA 162
+V+ L+ A+++ N T L A G +V+ +++ N + I K T L+ A
Sbjct: 284 IVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKAT 343
Query: 163 YKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIK----WRAAIVVNGH 218
+ +VV LL++ A +A G T LH A + + L++ R N
Sbjct: 344 KMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKA 403
Query: 219 GMTPLKVAAESCKADVVEL 237
G TP + K+ + ++
Sbjct: 404 GETPYNIDCSHQKSILTQI 422
Score = 35.0 bits (79), Expect = 0.21
Identities = 16/31 (51%), Positives = 24/31 (77%)
Query: 511 NALVTKLLLDCGAEVNAVDNEGNSALHIIVQ 541
N V +LLLD GA+V+AVD +G++ LHI ++
Sbjct: 347 NIEVVELLLDKGAKVSAVDKKGDTPLHIAIR 377
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 94.7 bits (234), Expect = 2e-19
Identities = 66/194 (34%), Positives = 101/194 (52%), Gaps = 2/194 (1%)
Query: 50 LIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGY-VIDGATALWCAAGAGHFEVVKLLV 108
LI AA G+ ++V LL+ ++ + + + + G TAL AAG G EV +LL+
Sbjct: 995 LIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLL 1054
Query: 109 SHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTD 168
GA V + PL + G IV L+ + A++++A+K T LM+AA +GH
Sbjct: 1055 EQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLG 1114
Query: 169 VVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI-VVNGHGMTPLKVAA 227
V +LL Q A G TAL +A GH+ +V+ L+ AA + +G TPL +AA
Sbjct: 1115 TVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAA 1174
Query: 228 ESCKADVVELLLSH 241
A+VV+ L+ H
Sbjct: 1175 FYGDAEVVQFLVDH 1188
Score = 87.0 bits (214), Expect = 5e-17
Identities = 67/193 (34%), Positives = 90/193 (46%), Gaps = 10/193 (5%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
T L AA G +V RLLLE Q GA L+ GH+++V LL
Sbjct: 1036 TALTAAAGRGKLEVCRLLLEQGAAVAQPNRR---------GAVPLFSTVRQGHWQIVDLL 1086
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
++HGA+VN TPL A +G L V +L+ A+I++ +K T L A KGH
Sbjct: 1087 LTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHL 1146
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIV-VNGHGMTPLKVA 226
VVR L++ A + G T L AA G ++V+ L+ A I V+ GM PL A
Sbjct: 1147 SVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRA 1206
Query: 227 AESCKADVVELLL 239
VV LL
Sbjct: 1207 VGCRNTSVVVTLL 1219
Score = 75.9 bits (185), Expect = 1e-13
Identities = 69/232 (29%), Positives = 102/232 (43%), Gaps = 29/232 (12%)
Query: 11 AASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYR 70
AA GK L + LLL + + V+Q + + PL R GH ++V LLL H
Sbjct: 1041 AAGRGK-LEVCRLLLEQGAA--------VAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGA 1091
Query: 71 VQTQQTGTVRFDGYVID--GATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAA 128
D + D G T L AA GH V L++ GA++ T L A
Sbjct: 1092 -----------DVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWA 1140
Query: 129 CFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGA 188
C G L +V+ LV+N A A+K T L +AA+ G +VV++L++ A + G
Sbjct: 1141 CLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGM 1200
Query: 189 TALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLS 240
L A + +V L+K G + P A + K D++ +LLS
Sbjct: 1201 RPLDRAVGCRNTSVVVTLLK-------KGAKIGPATWAMATSKPDIMIILLS 1245
Score = 62.0 bits (149), Expect = 2e-09
Identities = 55/173 (31%), Positives = 82/173 (47%), Gaps = 18/173 (10%)
Query: 85 VIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENN 144
V++ A L + G+ E+V LL+ GANV+ ++ + TPL A G L IV L +
Sbjct: 882 VLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKR 941
Query: 145 ANISIANKYDNTCLMIAAYKGHTDVVRYLLE-------QRADPNAKAHCGATALHFAAEA 197
A + +K L+ AA +GH +VV++L++ Q+ K+H AL AA
Sbjct: 942 AKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASM 1001
Query: 198 GHIDIVKELIKW---------RAAI--VVNGHGMTPLKVAAESCKADVVELLL 239
G+ +IV L+ RA I + G T L AA K +V LLL
Sbjct: 1002 GYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLL 1054
Score = 53.9 bits (128), Expect = 4e-07
Identities = 51/173 (29%), Positives = 85/173 (49%), Gaps = 18/173 (10%)
Query: 100 HFEVVKLLVSHGANVNH-TTVTNSTPLRAACFDGRL---DIVKYLVENNANISIANKYDN 155
+ +V +LL+ GAN+N+ T V N+ P+ C L ++V L+E AN+ +++
Sbjct: 862 NIKVSRLLILGGANINYRTEVLNNAPI--LCVQSHLGYTEMVALLLEFGANVDASSESGL 919
Query: 156 TCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIK--WRAA- 212
T L AA G+ +V L ++RA + G AL AA GH+++VK LI+ W A
Sbjct: 920 TPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAG 979
Query: 213 ----IVVNGHGMTPLKVAAESC-KADVVELLLSHADCD----RRSRIEALELL 256
+ H + +AA S ++V LL + D R++I + + L
Sbjct: 980 QQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSL 1032
Score = 32.7 bits (73), Expect = 1.0
Identities = 26/90 (28%), Positives = 36/90 (40%), Gaps = 25/90 (27%)
Query: 514 VTKLLLDCGAEVNAVDNEGNSALHIIVQYNR-PISDFLTLH------------------- 553
+ LLL GA+VN D +G + L + DFL
Sbjct: 1082 IVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWAC 1141
Query: 554 -----SIIISLVEAGAHTDMTNKQNKTPLD 578
S++ SLV+ GA TD +K +TPLD
Sbjct: 1142 LKGHLSVVRSLVDNGAATDHADKNGRTPLD 1171
Score = 30.8 bits (68), Expect = 3.9
Identities = 21/68 (30%), Positives = 36/68 (52%), Gaps = 6/68 (8%)
Query: 510 PNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMT 569
PN V++LL+ GA +N N+A + VQ + ++ + L L+E GA+ D +
Sbjct: 861 PNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVAL------LLEFGANVDAS 914
Query: 570 NKQNKTPL 577
++ TPL
Sbjct: 915 SESGLTPL 922
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 93.6 bits (231), Expect = 5e-19
Identities = 69/191 (36%), Positives = 95/191 (49%), Gaps = 13/191 (6%)
Query: 39 VSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGA 98
VS +GG+ T L AA NGH ++V LLL + + AL AA
Sbjct: 110 VSDRGGR--TALHHAALNGHVEMVNLLL---------AKGANINAFDKKDRRALHWAAYM 158
Query: 99 GHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCL 158
GH +VV LL++HGA V TPL AA +G++++VK+L+ I N Y NT L
Sbjct: 159 GHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTAL 218
Query: 159 MIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIV--VN 216
IA Y G VV L++ A+ N + G T LHFAA + H + EL+ A V +
Sbjct: 219 HIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQS 278
Query: 217 GHGMTPLKVAA 227
G +PL + A
Sbjct: 279 KDGKSPLHMTA 289
Score = 91.7 bits (226), Expect = 2e-18
Identities = 74/231 (32%), Positives = 111/231 (48%), Gaps = 24/231 (10%)
Query: 23 LLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFD 82
LLL R+ S G+ G +PL +AA NGH + + +LL+ V D
Sbjct: 525 LLLERTNS------GFEESDSGATKSPLHLAAYNGHHQALEVLLQ---------SLVDLD 569
Query: 83 GYVIDGATALWCAAGAGHFEVVKLLVSHGANV-NHTTVTNSTPLRAACFDGRLDIVKYLV 141
G TAL AA GH E V+ L++ GA++ VT TPL A+ +G ++ L+
Sbjct: 570 IRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLL 629
Query: 142 E---NNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAG 198
E N + + + T LM+A GH D V LLE+ A+ + G TALH G
Sbjct: 630 EIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTG 689
Query: 199 HIDIVKELIKWRAAIVV-NGHGMTPLKVAAESCKA----DVVELLLSHADC 244
H + V+ L++ +I+ + G TPL AA A +++++ LS DC
Sbjct: 690 HEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDC 740
Score = 79.7 bits (195), Expect = 7e-15
Identities = 61/204 (29%), Positives = 102/204 (50%), Gaps = 12/204 (5%)
Query: 39 VSQQGGQRSTPLIIAARNGHAKVVRLL-LEHYRVQTQQTGTVRFDGYVIDGATALWCAAG 97
V+ ++ TPL +AA G A+++ LL L RV + + T L A
Sbjct: 9 VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWL----------TPLHRAVA 58
Query: 98 AGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTC 157
+ E V++L+ H A+VN TPL A + + + ++ ++++++++ T
Sbjct: 59 SRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTA 118
Query: 158 LMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVV-N 216
L AA GH ++V LL + A+ NA ALH+AA GH+D+V LI A + +
Sbjct: 119 LHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKD 178
Query: 217 GHGMTPLKVAAESCKADVVELLLS 240
G TPL AA + + +VV+ LL+
Sbjct: 179 KKGYTPLHAAASNGQINVVKHLLN 202
Score = 68.2 bits (165), Expect = 2e-11
Identities = 64/226 (28%), Positives = 95/226 (42%), Gaps = 25/226 (11%)
Query: 87 DGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNAN 146
DG T L AA GH ++ L + GA+ + + PL A + D + L+ +
Sbjct: 313 DGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFE 372
Query: 147 ISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKEL 206
I +K+ TCL AA G+ + ++ L AD + K CG T LH+AA H ++ L
Sbjct: 373 IDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETL 432
Query: 207 IKWRAAI-VVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRE 265
+ A + + G T L AA S D DR I LG + N E
Sbjct: 433 VTTGANVNETDDWGRTALHYAAAS-------------DMDRNKTI-----LGNAHDNSEE 474
Query: 266 ---NYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIH---AYGNR 305
++ + L L L + +I +KE IH AYG+R
Sbjct: 475 LERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHR 520
Score = 66.6 bits (161), Expect = 6e-11
Identities = 57/201 (28%), Positives = 84/201 (41%), Gaps = 9/201 (4%)
Query: 46 RSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVK 105
+ TPL + NGH +RLLLE D G T L A GH + V
Sbjct: 609 KRTPLHASVINGHTLCLRLLLEI------ADNPEAVDVKDAKGQTPLMLAVAYGHIDAVS 662
Query: 106 LLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKG 165
LL+ ANV+ + T L G + V+ L+E +I + T L AA +G
Sbjct: 663 LLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARG 722
Query: 166 HTDVVRYLLEQ---RADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTP 222
H + LL+ D K + G T LH+A G+ + ++ L++ + G+ TP
Sbjct: 723 HATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTP 782
Query: 223 LKVAAESCKADVVELLLSHAD 243
L A + + LLL D
Sbjct: 783 LHCAIINDHGNCASLLLGAID 803
Score = 64.7 bits (156), Expect = 2e-10
Identities = 103/398 (25%), Positives = 151/398 (37%), Gaps = 92/398 (23%)
Query: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
++ AAS G++ + LL E D + G +T L IA NG VV L++
Sbjct: 185 LHAAASNGQINVVKHLLNLGVEIDEINVYG---------NTALHIACYNGQDAVVNELID 235
Query: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEV-VKLLVSHGANVNHTTVTNSTPLR 126
Y Q +G T L AA + H + ++LLV++GA+VN + +PL
Sbjct: 236 -YGANVNQPNN--------NGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLH 286
Query: 127 AACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADP------ 180
GR + L++N I +K NT L +AA GH ++ L AD
Sbjct: 287 MTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIH 346
Query: 181 ----------NAKAHC-----------------GATALHFAAEAGHIDIVKELIKWRAAI 213
NA + C G T LH AA G+++ +K L A
Sbjct: 347 SMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADF 406
Query: 214 VVNGH-GMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDIIKT 272
G TPL AA +C H C +E L + AN E D +T
Sbjct: 407 HKKDKCGRTPLHYAAANC----------HFHC--------IETLVTTGANVNETDDWGRT 448
Query: 273 -YHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRDALHMEGLIV 331
HY + ++R K +L H N +ELE R+ ++ E +
Sbjct: 449 ALHYAAASDMDR--------NKTILGNAH--------DNSEELERARELKE---KEATLC 489
Query: 332 RERILGAD-NIDVSHPIIYRGAVYADNMEFEQCIKLWL 368
E +L D N + Y YA QC++L L
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLL 527
Score = 60.1 bits (144), Expect = 6e-09
Identities = 48/181 (26%), Positives = 89/181 (49%), Gaps = 14/181 (7%)
Query: 87 DGATALWCAAGAGHFEVVKLLVSH---GANVNHTTVTNSTPLRAACFDGRLDIVKYLVEN 143
+G ++ AA GH + ++LL+ G + + T S PL A ++G ++ L+++
Sbjct: 506 EGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKS-PLHLAAYNGHHQALEVLLQS 564
Query: 144 NANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAH-CGATALHFAAEAGHIDI 202
++ I ++ T L +AA+KGHT+ V L+ A K + T LH + GH
Sbjct: 565 LVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLC 624
Query: 203 VKELIKW----RAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGA 258
++ L++ A V + G TPL +A D V LLL ++ + ++ +++LG
Sbjct: 625 LRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL-----EKEANVDTVDILGC 679
Query: 259 S 259
+
Sbjct: 680 T 680
Score = 59.7 bits (143), Expect = 8e-09
Identities = 47/153 (30%), Positives = 72/153 (47%), Gaps = 1/153 (0%)
Query: 90 TALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISI 149
T L AA G E+++LL+ GA VN TPL A + V+ L++++A+++
Sbjct: 18 TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77
Query: 150 ANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKW 209
+K T L +AA ++ + N G TALH AA GH+++V L+
Sbjct: 78 RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137
Query: 210 RAAI-VVNGHGMTPLKVAAESCKADVVELLLSH 241
A I + L AA DVV LL++H
Sbjct: 138 GANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
Score = 58.9 bits (141), Expect = 1e-08
Identities = 67/254 (26%), Positives = 101/254 (39%), Gaps = 51/254 (20%)
Query: 49 PLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVID-----GATALWCAAGAGHFEV 103
PL +AA N H+ R LL G+ ID G T L AA G+ E
Sbjct: 350 PLHLAALNAHSDCCRKLLS--------------SGFEIDTPDKFGRTCLHAAAAGGNVEC 395
Query: 104 VKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAY 163
+KLL S GA+ + TPL A + ++ LV AN++ + + T L AA
Sbjct: 396 IKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAA 455
Query: 164 ----------------------------KGHTDVVRYLLEQRADPNAKAHCGATALHFAA 195
K T + +LL+ A+P+ + G ++H+AA
Sbjct: 456 SDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAA 515
Query: 196 EAGHIDIVKELI-KWRAAIVVNGHGMT--PLKVAAESCKADVVELLL-SHADCDRRSRIE 251
GH ++ L+ + + + G T PL +AA + +E+LL S D D R
Sbjct: 516 AYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKG 575
Query: 252 ALELLGASFANDRE 265
L A+F E
Sbjct: 576 RTALDLAAFKGHTE 589
Score = 53.1 bits (126), Expect = 7e-07
Identities = 60/224 (26%), Positives = 92/224 (41%), Gaps = 40/224 (17%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
T L AA G+ + ++LL Q+ F G T L AA HF ++ L
Sbjct: 382 TCLHAAAAGGNVECIKLL---------QSSGADFHKKDKCGRTPLHYAAANCHFHCIETL 432
Query: 108 VSHGANVNHTTVTNSTPLRAAC--------------FDGRLDI--------------VKY 139
V+ GANVN T T L A D ++ +++
Sbjct: 433 VTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEF 492
Query: 140 LVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGAT--ALHFAAEA 197
L++N+AN SI +K + AA GH + LLE+ ++ GAT LH AA
Sbjct: 493 LLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYN 552
Query: 198 GHIDIVKELIKWRAAIVVNGH-GMTPLKVAAESCKADVVELLLS 240
GH ++ L++ + + G T L +AA + VE L++
Sbjct: 553 GHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALIN 596
Score = 50.1 bits (118), Expect = 6e-06
Identities = 44/142 (30%), Positives = 63/142 (44%), Gaps = 18/142 (12%)
Query: 44 GQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVID-----GATALWCAAGA 98
G TPL A N H LLL G + D ++ G T L AA A
Sbjct: 777 GNPFTPLHCAIINDHGNCASLLL----------GAI--DSSIVSCRDDKGRTPLRAAAFA 824
Query: 99 GHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVEN-NANISIANKYDNTC 157
H E ++LL+ H A VN + T L A +G+ V LV + A++++ +K NT
Sbjct: 825 DHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTP 884
Query: 158 LMIAAYKGHTDVVRYLLEQRAD 179
L +A KGH +L++ D
Sbjct: 885 LHLACSKGHEKCALLILDKIQD 906
Score = 46.6 bits (109), Expect = 7e-05
Identities = 37/136 (27%), Positives = 64/136 (47%), Gaps = 1/136 (0%)
Query: 106 LLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKG 165
+L+ +VN TPL A F G +I++ L+ + A ++ + T L A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 166 HTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGH-GMTPLK 224
+ V+ L++ AD NA+ T LH AA + + +I +++ V+ G T L
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 225 VAAESCKADVVELLLS 240
AA + ++V LLL+
Sbjct: 121 HAALNGHVEMVNLLLA 136
Score = 43.9 bits (102), Expect = 4e-04
Identities = 62/260 (23%), Positives = 91/260 (35%), Gaps = 81/260 (31%)
Query: 39 VSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGA 98
V + + TPL++A GH V LLLE D I G TAL
Sbjct: 638 VDVKDAKGQTPLMLAVAYGHIDAVSLLLEK---------EANVDTVDILGCTALHRGIMT 688
Query: 99 GHFEVVKLLVSHGANV-----------------NHTTVTNS------------------- 122
GH E V++L+ ++ H T +
Sbjct: 689 GHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGY 748
Query: 123 TPLRAACFDGRLDIVKYLVENNA------------NISIANKYDN--------------- 155
TPL AC++G + ++ L+E + +I N + N
Sbjct: 749 TPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVS 808
Query: 156 -------TCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELI- 207
T L AA+ H + ++ LL A NA + G TAL AAE G V L+
Sbjct: 809 CRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN 868
Query: 208 KWRAAIVVNGHGM-TPLKVA 226
+A + V + TPL +A
Sbjct: 869 SAQADLTVKDKDLNTPLHLA 888
Score = 36.6 bits (83), Expect = 0.072
Identities = 39/136 (28%), Positives = 59/136 (43%), Gaps = 16/136 (11%)
Query: 21 AALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVR 80
A+LLL +S I VS + + TPL AA H + ++LLL H +
Sbjct: 795 ASLLLGAIDSSI------VSCRDDKGRTPLRAAAFADHVECLQLLLRH---------SAP 839
Query: 81 FDGYVIDGATALWCAAGAGHFEVVKLLV-SHGANVNHTTVTNSTPLRAACFDGRLDIVKY 139
+ G TAL AA G V +LV S A++ +TPL AC G
Sbjct: 840 VNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALL 899
Query: 140 LVENNANISIANKYDN 155
+++ + S+ N+ +N
Sbjct: 900 ILDKIQDESLINEKNN 915
Score = 36.2 bits (82), Expect = 0.093
Identities = 28/98 (28%), Positives = 47/98 (47%), Gaps = 23/98 (23%)
Query: 480 RTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHII 539
+ ++G+T LH A SN ++ V K LL+ G E++ ++ GN+ALHI
Sbjct: 177 KDKKGYTPLHAAA-SNGQIN--------------VVKHLLNLGVEIDEINVYGNTALHIA 221
Query: 540 VQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPL 577
YN +++ L++ GA+ + N TPL
Sbjct: 222 C-YNGQ-------DAVVNELIDYGANVNQPNNNGFTPL 251
Score = 32.3 bits (72), Expect = 1.3
Identities = 41/192 (21%), Positives = 70/192 (36%), Gaps = 32/192 (16%)
Query: 441 ECNLY--TFLYLVCISTKTQCSEE------DQCKINKQIYNLIHLDPRTREGFTLLHLAV 492
E N+Y T L++ C + + E + + N + +H + G L L V
Sbjct: 209 EINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLV 268
Query: 493 NSNTPVDDFHTNDVCSFPNALV------TKLLLDCGAEVNAVDNEGNSALHIIVQYNRPI 546
N+ V+ + V ++ L+ G E++ VD +GN+ LH+ +Y +
Sbjct: 269 NNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHEL 328
Query: 547 SDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDKSTTGV----------SEILLKTQMKMS 596
+I +L +GA T + PL + S + T K
Sbjct: 329 --------LINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFG 380
Query: 597 LKCLAARAVRAN 608
CL A A N
Sbjct: 381 RTCLHAAAAGGN 392
Score = 30.0 bits (66), Expect = 6.7
Identities = 26/97 (26%), Positives = 43/97 (44%), Gaps = 14/97 (14%)
Query: 517 LLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTP 576
+L+ +VN +D+E + LH+ FL II L+ +GA + + TP
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAA--------FLGDAEIIELLILSGARVNAKDNMWLTP 52
Query: 577 LDKSTTGVSEILLKTQMKMSLKCLAARAVRANDINYQ 613
L ++ SE ++ +K S V A D N+Q
Sbjct: 53 LHRAVASRSEEAVQVLIKHSAD------VNARDKNWQ 83
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 92.8 bits (229), Expect = 8e-19
Identities = 79/277 (28%), Positives = 123/277 (44%), Gaps = 35/277 (12%)
Query: 32 IRYLLGYVS-----QQGGQRSTPLIIAARNGHAKVVRLLLEH-YRVQTQQTG-------- 77
+++LLG +S Q + PL+IAA G+ ++++LL++ R+ Q G
Sbjct: 360 LQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWA 419
Query: 78 -------TVRF--------DGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNS 122
T++F D G AL AA GH +V +LL S G+N N
Sbjct: 420 ARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEE 479
Query: 123 TPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNA 182
TPL A + G + K L E N++I N+ T L+ A+ +G+ D+V L E AD NA
Sbjct: 480 TPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNA 539
Query: 183 KAHCGATALHFAAEAGHIDIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLLSH 241
G ALH A ++++K L+ + + HG TPL VA + +V L
Sbjct: 540 CDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVAL--- 596
Query: 242 ADCDRRSRIEALELLGASFANDRENYDIIKTYHYLYL 278
C+ ++ G + + N I+ YL L
Sbjct: 597 --CEANCNLDISNKYGRTPLHLAANNGILDVVRYLCL 631
Score = 82.0 bits (201), Expect = 1e-15
Identities = 59/172 (34%), Positives = 78/172 (45%), Gaps = 9/172 (5%)
Query: 39 VSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGA 98
V+ + + TPL+ A+ G+ +V L EH + DG AL A
Sbjct: 504 VNIKNREGETPLLTASARGYHDIVECLAEH---------GADLNACDKDGHIALHLAVRR 554
Query: 99 GHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCL 158
EV+K L+S G V++ +TPL AC DG + IV L E N N+ I+NKY T L
Sbjct: 555 CQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPL 614
Query: 159 MIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWR 210
+AA G DVVRYL A A G TA A H + L + R
Sbjct: 615 HLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLR 666
Score = 38.9 bits (89), Expect = 0.014
Identities = 37/137 (27%), Positives = 59/137 (43%), Gaps = 27/137 (19%)
Query: 482 REGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQ 541
++G LHLAV C V K LL G V+ D GN+ LH+ +
Sbjct: 542 KDGHIALHLAVRR------------CQME---VIKTLLSQGCFVDYQDRHGNTPLHVACK 586
Query: 542 Y-NRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLD-KSTTGVSEIL-LKTQMKMSLK 598
N PI +++L EA + D++NK +TPL + G+ +++ M S++
Sbjct: 587 DGNMPI---------VVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVE 637
Query: 599 CLAARAVRANDINYQDQ 615
L A D+ +Q
Sbjct: 638 ALTTDGKTAEDLARSEQ 654
Score = 33.9 bits (76), Expect = 0.46
Identities = 26/105 (24%), Positives = 44/105 (41%), Gaps = 23/105 (21%)
Query: 473 NLIHLDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEG 532
N LD + + G LH+A + +A V +LL G+ N D E
Sbjct: 434 NKCPLDVKDKSGEMALHVAAR---------------YGHADVAQLLCSFGSNPNIQDKEE 478
Query: 533 NSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPL 577
+ LH + +S+ +L EAG + ++ N++ +TPL
Sbjct: 479 ETPLHCAAWHG--------YYSVAKALCEAGCNVNIKNREGETPL 515
>gi|140161500 ankyrin repeat and sterile alpha motif domain
containing 1 [Homo sapiens]
Length = 1134
Score = 91.3 bits (225), Expect = 2e-18
Identities = 73/210 (34%), Positives = 102/210 (48%), Gaps = 18/210 (8%)
Query: 49 PLIIAARNGHAKVVRLLLE----HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVV 104
PL +AA G A++VRLL+ H RV Q D TAL CAA GH EVV
Sbjct: 116 PLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNN----------DNETALHCAAQYGHTEVV 165
Query: 105 KLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYK 164
K+L+ + TPL A GRL++VK L+ + N+ N +T L +AA
Sbjct: 166 KVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARN 225
Query: 165 GHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI-VVNGHGMTPL 223
GH VV+ LL+ D N + G +ALH AA G D+V+ L+ + + + HG+T L
Sbjct: 226 GHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
Query: 224 KVAAE--SCKADVVELLLSHADCDRRSRIE 251
E S K+ + L+ +RS E
Sbjct: 285 DTVRELPSQKSQQIAALIEDHMTGKRSTKE 314
Score = 72.8 bits (177), Expect = 9e-13
Identities = 64/201 (31%), Positives = 94/201 (46%), Gaps = 14/201 (6%)
Query: 50 LIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAG------HFEV 103
L+ AAR GH V LL R+ + G G G G G H
Sbjct: 7 LLEAARTGHLPAVEKLLSGKRLSSGFGG----GGGGGSGGGGGGSGGGGGGLGSSSHPLS 62
Query: 104 VKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAY 163
L + G NVN T TPL A +G D+V+ L+ N+A ++A+ L +AA+
Sbjct: 63 SLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAW 122
Query: 164 KGHTDVVRYLLEQ---RADPNAKAHCGATALHFAAEAGHIDIVKELI-KWRAAIVVNGHG 219
KG +VR L+ Q N + + TALH AA+ GH ++VK L+ + + N
Sbjct: 123 KGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKF 182
Query: 220 MTPLKVAAESCKADVVELLLS 240
TPL +AA + +VV++LL+
Sbjct: 183 ETPLDLAALYGRLEVVKMLLN 203
Score = 63.5 bits (153), Expect = 5e-10
Identities = 55/177 (31%), Positives = 83/177 (46%), Gaps = 15/177 (8%)
Query: 20 LAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTV 79
+ LL+++ S R V++Q T L AA+ GH +VV++LLE T +
Sbjct: 128 IVRLLIHQGPSHTR-----VNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN-- 180
Query: 80 RFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKY 139
+F+ T L AA G EVVK+L++ N+ TPL A +G +V+
Sbjct: 181 KFE-------TPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQV 233
Query: 140 LVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAE 196
L++ + + + + L AA G TDVV+ LL D N K + G TAL E
Sbjct: 234 LLDAGMDSNYQTEM-GSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRE 289
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
sapiens]
Length = 2542
Score = 91.3 bits (225), Expect = 2e-18
Identities = 83/250 (33%), Positives = 116/250 (46%), Gaps = 31/250 (12%)
Query: 40 SQQGGQRSTPLIIAARNGHAKVVRLLL------EHYRVQTQQTGTVRFDGYVID------ 87
+Q + TPL +A G +VV LLL EH V ++ G ++
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 88 --------------GATALWCAAGAGHFEVVKLLVSHGANVNHTTVTN-STPLRAACFDG 132
G + L AA GH VKLL+ G+++N TN +T L ACF G
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
Query: 133 RLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGA--TA 190
R ++V L++ AN+ K T LM AA G+ +V R LL++ AD NA + TA
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
Query: 191 LHFAAEAGHIDIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLL-SHADCDRRS 248
L AA+ GH + LI A I V N G TPL +A+ DVV+LL+ + AD D
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
Query: 249 RIEALELLGA 258
+ L+ A
Sbjct: 1356 NRKITPLMSA 1365
Score = 87.8 bits (216), Expect = 3e-17
Identities = 82/254 (32%), Positives = 122/254 (48%), Gaps = 32/254 (12%)
Query: 12 ASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE---H 68
A+ G + LAALL+ R + L V+ +G TPL+ AAR GH ++V LLL +
Sbjct: 445 AACGGHVELAALLIERGAN-----LEEVNDEG---YTPLMEAAREGHEEMVALLLAQGAN 496
Query: 69 YRVQTQQTGTVRF------------DGYVIDGA-------TALWCAAGAGHFEVVKLLVS 109
QT++T D + GA T L A+ GH E+VK L++
Sbjct: 497 INAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLA 556
Query: 110 HGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDV 169
GANV+ TT T T L AC +G D+ L++ A++ ++ T LM AA GH
Sbjct: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCT 616
Query: 170 VRYLLEQRADPN-AKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVN-GHGMTPLKVAA 227
V++L+ + A+ N A A+ T + A GH+ +V+ L+ A G T L AA
Sbjct: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 676
Query: 228 ESCKADVVELLLSH 241
+ +VV LL +
Sbjct: 677 KGGHTNVVSYLLDY 690
Score = 82.8 bits (203), Expect = 9e-16
Identities = 84/285 (29%), Positives = 124/285 (43%), Gaps = 50/285 (17%)
Query: 10 KAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHY 69
+AAS G V +A +LL+ G + + + L +A GH +VR LLE
Sbjct: 344 EAASAGHV-EVARVLLDHGA-------GINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
Query: 70 RVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAAC 129
Q +T + TAL A GH EV +LL+ GA VN + +PL A
Sbjct: 396 ADQEHKTDEMH---------TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 446
Query: 130 FDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAK------ 183
G +++ L+E AN+ N T LM AA +GH ++V LL Q A+ NA+
Sbjct: 447 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE 506
Query: 184 -----AHCG--------------------ATALHFAAEAGHIDIVKELIKWRAAI-VVNG 217
A CG +T L A++ GH+++VK L+ A +
Sbjct: 507 TALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTA 566
Query: 218 HGMTPLKVAAESCKADVVELLL-SHADCDRRSRIEALELLGASFA 261
G T L A E+ DV ++LL + AD + S L+ A+ A
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARA 611
Score = 81.6 bits (200), Expect = 2e-15
Identities = 48/120 (40%), Positives = 70/120 (58%), Gaps = 1/120 (0%)
Query: 90 TALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISI 149
T L A+ G+ ++VKLL+ H A+VN + T +T L AC G +DIVK L+ ANI
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 150 ANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAH-CGATALHFAAEAGHIDIVKELIK 208
N+ +T LM AA GH +V R LL+ A N ++ +AL A GH+D+V+ L++
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Score = 79.7 bits (195), Expect = 7e-15
Identities = 64/209 (30%), Positives = 102/209 (48%), Gaps = 19/209 (9%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
T L +A GH ++V +L+ + + G T L AA AGH VV++L
Sbjct: 1057 TALTLACAGGHEELVSVLIAR---------DAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107
Query: 108 VSHGANVN-HTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGH 166
+ G ++ + T TPL AC GR ++V L+ AN N D T L +AA G+
Sbjct: 1108 LDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGY 1167
Query: 167 TDVVRYLLEQRADPNAK--AHCGATALHFAAEAGHIDIVKELIKWRAAI--VVNGHGMTP 222
++++ LL A+ N++ + G + L AA GH+ VK L+ + I + + T
Sbjct: 1168 VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTA 1227
Query: 223 LKVAAESCKADVVELLLSHADCDRRSRIE 251
L +A +A+VV LLL DR++ +E
Sbjct: 1228 LTLACFQGRAEVVSLLL-----DRKANVE 1251
Score = 79.0 bits (193), Expect = 1e-14
Identities = 57/165 (34%), Positives = 83/165 (50%), Gaps = 11/165 (6%)
Query: 46 RSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVK 105
R+T L +A G A+VV LLL+ + T G T L AA G+ EV +
Sbjct: 1224 RNTALTLACFQGRAEVVSLLLDRKANVEHRAKT---------GLTPLMEAASGGYAEVGR 1274
Query: 106 LLVSHGANVNHTTVTNS--TPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAY 163
+L+ GA+VN V +S T L A G + L+ A+I + NK NT L +A+
Sbjct: 1275 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASN 1334
Query: 164 KGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIK 208
GH DVV+ L++ AD +A + T L A GH+ +V+ L+K
Sbjct: 1335 GGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 76.6 bits (187), Expect = 6e-14
Identities = 65/218 (29%), Positives = 104/218 (47%), Gaps = 14/218 (6%)
Query: 40 SQQGGQRST-PLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGA 98
S GQ T L A +G VR LL+ R + T +G + L A A
Sbjct: 198 SHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE---------EGESLLCLACSA 248
Query: 99 GHFEVVKLLVSHGANV-NHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTC 157
G++E+ ++L++ ANV + + TPL AA G LDIVK L+ ++A+++ + NT
Sbjct: 249 GYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA 308
Query: 158 LMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNG 217
L A G D+V+ LL + A+ G T L AA AGH+++ + L+ A I +
Sbjct: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368
Query: 218 HGM--TPLKVAAESCKADVVELLLSHADCDRRSRIEAL 253
+ + L +A D+V LL A D+ + + +
Sbjct: 369 NEFKESALTLACYKGHLDMVRFLL-EAGADQEHKTDEM 405
Score = 75.1 bits (183), Expect = 2e-13
Identities = 50/166 (30%), Positives = 82/166 (49%), Gaps = 8/166 (4%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL+ AA GH +V R+LL+H + + +AL A GH ++V+ L
Sbjct: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFK--------ESALTLACYKGHLDMVRFL 391
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ GA+ H T T L AC DG +++ + L+++ A +++ + L +AA GH
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI 213
++ L+E+ A+ G T L AA GH ++V L+ A I
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
Score = 69.3 bits (168), Expect = 1e-11
Identities = 45/129 (34%), Positives = 69/129 (53%), Gaps = 7/129 (5%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL+ AA G+A+V R+LL+ + V TAL AA GH++ +LL
Sbjct: 1259 TPLMEAASGGYAEVGRVLLD-------KGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1311
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ GA+++ +TPL A G D+V+ LV+ A++ A+ T LM A KGH
Sbjct: 1312 IHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHV 1371
Query: 168 DVVRYLLEQ 176
VV+YL+++
Sbjct: 1372 KVVQYLVKE 1380
Score = 52.8 bits (125), Expect = 1e-06
Identities = 40/128 (31%), Positives = 63/128 (49%), Gaps = 4/128 (3%)
Query: 116 HTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLE 175
HT + T L AC G ++V L+ +A I +K T L++AA GH VV LL+
Sbjct: 1050 HTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD 1109
Query: 176 QRADPNAKA-HCGATALHFAAEAGHIDIVKELIKWRAAIVV--NGHGMTPLKVAAESCKA 232
+ D A++ T L A G ++V +L+ R A N TPL +AA
Sbjct: 1110 KGGDIEAQSERTKDTPLSLACSGGRQEVV-DLLLARGANKEHRNVSDYTPLSLAASGGYV 1168
Query: 233 DVVELLLS 240
+++++LL+
Sbjct: 1169 NIIKILLN 1176
Score = 49.7 bits (117), Expect = 8e-06
Identities = 34/106 (32%), Positives = 51/106 (48%), Gaps = 10/106 (9%)
Query: 42 QGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHF 101
+GG+ TPL+ AAR GH V+ L+ + T + T + A GH
Sbjct: 599 EGGR--TPLMKAARAGHLCTVQFLISKGANVNRATAN--------NDHTVVSLACAGGHL 648
Query: 102 EVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANI 147
VV+LL++HGA+ H ST L A G ++V YL++ N+
Sbjct: 649 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694
Score = 34.3 bits (77), Expect = 0.36
Identities = 26/78 (33%), Positives = 35/78 (44%), Gaps = 9/78 (11%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
T + +A GH VV LLL H T + + DG+T L AA GH VV L
Sbjct: 637 TVVSLACAGGHLAVVELLLAHGADPTHR---------LKDGSTMLIEAAKGGHTNVVSYL 687
Query: 108 VSHGANVNHTTVTNSTPL 125
+ + NV T+ + L
Sbjct: 688 LDYPNNVLSVPTTDVSQL 705
Score = 34.3 bits (77), Expect = 0.36
Identities = 23/72 (31%), Positives = 36/72 (50%), Gaps = 6/72 (8%)
Query: 512 ALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNK 571
A V ++LLD GA+VNA + + + ++ F L L+ GAH D+ NK
Sbjct: 1270 AEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL------LIHRGAHIDVRNK 1323
Query: 572 QNKTPLDKSTTG 583
+ TPL ++ G
Sbjct: 1324 KGNTPLWLASNG 1335
Score = 32.3 bits (72), Expect = 1.3
Identities = 26/93 (27%), Positives = 41/93 (44%), Gaps = 10/93 (10%)
Query: 487 LLHLAVNSNTPVDDFHTN--DVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNR 544
LL + D+ HT + C + V +LLLD GA+VN + S L +
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA---- 446
Query: 545 PISDFLTLHSIIISLVEAGAHTDMTNKQNKTPL 577
+ L ++ L+E GA+ + N + TPL
Sbjct: 447 -CGGHVELAAL---LIERGANLEEVNDEGYTPL 475
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 91.3 bits (225), Expect = 2e-18
Identities = 83/250 (33%), Positives = 116/250 (46%), Gaps = 31/250 (12%)
Query: 40 SQQGGQRSTPLIIAARNGHAKVVRLLL------EHYRVQTQQTGTVRFDGYVID------ 87
+Q + TPL +A G +VV LLL EH V ++ G ++
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 88 --------------GATALWCAAGAGHFEVVKLLVSHGANVNHTTVTN-STPLRAACFDG 132
G + L AA GH VKLL+ G+++N TN +T L ACF G
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
Query: 133 RLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGA--TA 190
R ++V L++ AN+ K T LM AA G+ +V R LL++ AD NA + TA
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
Query: 191 LHFAAEAGHIDIVKELIKWRAAI-VVNGHGMTPLKVAAESCKADVVELLL-SHADCDRRS 248
L AA+ GH + LI A I V N G TPL +A+ DVV+LL+ + AD D
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
Query: 249 RIEALELLGA 258
+ L+ A
Sbjct: 1356 NRKITPLMSA 1365
Score = 87.8 bits (216), Expect = 3e-17
Identities = 82/254 (32%), Positives = 122/254 (48%), Gaps = 32/254 (12%)
Query: 12 ASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE---H 68
A+ G + LAALL+ R + L V+ +G TPL+ AAR GH ++V LLL +
Sbjct: 445 AACGGHVELAALLIERGAN-----LEEVNDEG---YTPLMEAAREGHEEMVALLLAQGAN 496
Query: 69 YRVQTQQTGTVRF------------DGYVIDGA-------TALWCAAGAGHFEVVKLLVS 109
QT++T D + GA T L A+ GH E+VK L++
Sbjct: 497 INAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLA 556
Query: 110 HGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDV 169
GANV+ TT T T L AC +G D+ L++ A++ ++ T LM AA GH
Sbjct: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCT 616
Query: 170 VRYLLEQRADPN-AKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVN-GHGMTPLKVAA 227
V++L+ + A+ N A A+ T + A GH+ +V+ L+ A G T L AA
Sbjct: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 676
Query: 228 ESCKADVVELLLSH 241
+ +VV LL +
Sbjct: 677 KGGHTNVVSYLLDY 690
Score = 82.8 bits (203), Expect = 9e-16
Identities = 84/285 (29%), Positives = 124/285 (43%), Gaps = 50/285 (17%)
Query: 10 KAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHY 69
+AAS G V +A +LL+ G + + + L +A GH +VR LLE
Sbjct: 344 EAASAGHV-EVARVLLDHGA-------GINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
Query: 70 RVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAAC 129
Q +T + TAL A GH EV +LL+ GA VN + +PL A
Sbjct: 396 ADQEHKTDEMH---------TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 446
Query: 130 FDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAK------ 183
G +++ L+E AN+ N T LM AA +GH ++V LL Q A+ NA+
Sbjct: 447 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE 506
Query: 184 -----AHCG--------------------ATALHFAAEAGHIDIVKELIKWRAAI-VVNG 217
A CG +T L A++ GH+++VK L+ A +
Sbjct: 507 TALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTA 566
Query: 218 HGMTPLKVAAESCKADVVELLL-SHADCDRRSRIEALELLGASFA 261
G T L A E+ DV ++LL + AD + S L+ A+ A
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARA 611
Score = 81.6 bits (200), Expect = 2e-15
Identities = 48/120 (40%), Positives = 70/120 (58%), Gaps = 1/120 (0%)
Query: 90 TALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISI 149
T L A+ G+ ++VKLL+ H A+VN + T +T L AC G +DIVK L+ ANI
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 150 ANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAH-CGATALHFAAEAGHIDIVKELIK 208
N+ +T LM AA GH +V R LL+ A N ++ +AL A GH+D+V+ L++
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Score = 79.7 bits (195), Expect = 7e-15
Identities = 64/209 (30%), Positives = 102/209 (48%), Gaps = 19/209 (9%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
T L +A GH ++V +L+ + + G T L AA AGH VV++L
Sbjct: 1057 TALTLACAGGHEELVSVLIAR---------DAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107
Query: 108 VSHGANVN-HTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGH 166
+ G ++ + T TPL AC GR ++V L+ AN N D T L +AA G+
Sbjct: 1108 LDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGY 1167
Query: 167 TDVVRYLLEQRADPNAK--AHCGATALHFAAEAGHIDIVKELIKWRAAI--VVNGHGMTP 222
++++ LL A+ N++ + G + L AA GH+ VK L+ + I + + T
Sbjct: 1168 VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTA 1227
Query: 223 LKVAAESCKADVVELLLSHADCDRRSRIE 251
L +A +A+VV LLL DR++ +E
Sbjct: 1228 LTLACFQGRAEVVSLLL-----DRKANVE 1251
Score = 79.0 bits (193), Expect = 1e-14
Identities = 57/165 (34%), Positives = 83/165 (50%), Gaps = 11/165 (6%)
Query: 46 RSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVK 105
R+T L +A G A+VV LLL+ + T G T L AA G+ EV +
Sbjct: 1224 RNTALTLACFQGRAEVVSLLLDRKANVEHRAKT---------GLTPLMEAASGGYAEVGR 1274
Query: 106 LLVSHGANVNHTTVTNS--TPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAY 163
+L+ GA+VN V +S T L A G + L+ A+I + NK NT L +A+
Sbjct: 1275 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASN 1334
Query: 164 KGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIK 208
GH DVV+ L++ AD +A + T L A GH+ +V+ L+K
Sbjct: 1335 GGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 76.6 bits (187), Expect = 6e-14
Identities = 65/218 (29%), Positives = 104/218 (47%), Gaps = 14/218 (6%)
Query: 40 SQQGGQRST-PLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGA 98
S GQ T L A +G VR LL+ R + T +G + L A A
Sbjct: 198 SHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE---------EGESLLCLACSA 248
Query: 99 GHFEVVKLLVSHGANV-NHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTC 157
G++E+ ++L++ ANV + + TPL AA G LDIVK L+ ++A+++ + NT
Sbjct: 249 GYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA 308
Query: 158 LMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNG 217
L A G D+V+ LL + A+ G T L AA AGH+++ + L+ A I +
Sbjct: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368
Query: 218 HGM--TPLKVAAESCKADVVELLLSHADCDRRSRIEAL 253
+ + L +A D+V LL A D+ + + +
Sbjct: 369 NEFKESALTLACYKGHLDMVRFLL-EAGADQEHKTDEM 405
Score = 75.1 bits (183), Expect = 2e-13
Identities = 50/166 (30%), Positives = 82/166 (49%), Gaps = 8/166 (4%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL+ AA GH +V R+LL+H + + +AL A GH ++V+ L
Sbjct: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFK--------ESALTLACYKGHLDMVRFL 391
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ GA+ H T T L AC DG +++ + L+++ A +++ + L +AA GH
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
Query: 168 DVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI 213
++ L+E+ A+ G T L AA GH ++V L+ A I
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
Score = 69.3 bits (168), Expect = 1e-11
Identities = 45/129 (34%), Positives = 69/129 (53%), Gaps = 7/129 (5%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
TPL+ AA G+A+V R+LL+ + V TAL AA GH++ +LL
Sbjct: 1259 TPLMEAASGGYAEVGRVLLD-------KGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1311
Query: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
+ GA+++ +TPL A G D+V+ LV+ A++ A+ T LM A KGH
Sbjct: 1312 IHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHV 1371
Query: 168 DVVRYLLEQ 176
VV+YL+++
Sbjct: 1372 KVVQYLVKE 1380
Score = 52.8 bits (125), Expect = 1e-06
Identities = 40/128 (31%), Positives = 63/128 (49%), Gaps = 4/128 (3%)
Query: 116 HTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLE 175
HT + T L AC G ++V L+ +A I +K T L++AA GH VV LL+
Sbjct: 1050 HTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD 1109
Query: 176 QRADPNAKA-HCGATALHFAAEAGHIDIVKELIKWRAAIVV--NGHGMTPLKVAAESCKA 232
+ D A++ T L A G ++V +L+ R A N TPL +AA
Sbjct: 1110 KGGDIEAQSERTKDTPLSLACSGGRQEVV-DLLLARGANKEHRNVSDYTPLSLAASGGYV 1168
Query: 233 DVVELLLS 240
+++++LL+
Sbjct: 1169 NIIKILLN 1176
Score = 49.7 bits (117), Expect = 8e-06
Identities = 34/106 (32%), Positives = 51/106 (48%), Gaps = 10/106 (9%)
Query: 42 QGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHF 101
+GG+ TPL+ AAR GH V+ L+ + T + T + A GH
Sbjct: 599 EGGR--TPLMKAARAGHLCTVQFLISKGANVNRATAN--------NDHTVVSLACAGGHL 648
Query: 102 EVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANI 147
VV+LL++HGA+ H ST L A G ++V YL++ N+
Sbjct: 649 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694
Score = 34.3 bits (77), Expect = 0.36
Identities = 26/78 (33%), Positives = 35/78 (44%), Gaps = 9/78 (11%)
Query: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
T + +A GH VV LLL H T + + DG+T L AA GH VV L
Sbjct: 637 TVVSLACAGGHLAVVELLLAHGADPTHR---------LKDGSTMLIEAAKGGHTNVVSYL 687
Query: 108 VSHGANVNHTTVTNSTPL 125
+ + NV T+ + L
Sbjct: 688 LDYPNNVLSVPTTDVSQL 705
Score = 34.3 bits (77), Expect = 0.36
Identities = 23/72 (31%), Positives = 36/72 (50%), Gaps = 6/72 (8%)
Query: 512 ALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNK 571
A V ++LLD GA+VNA + + + ++ F L L+ GAH D+ NK
Sbjct: 1270 AEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL------LIHRGAHIDVRNK 1323
Query: 572 QNKTPLDKSTTG 583
+ TPL ++ G
Sbjct: 1324 KGNTPLWLASNG 1335
Score = 32.3 bits (72), Expect = 1.3
Identities = 26/93 (27%), Positives = 41/93 (44%), Gaps = 10/93 (10%)
Query: 487 LLHLAVNSNTPVDDFHTN--DVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNR 544
LL + D+ HT + C + V +LLLD GA+VN + S L +
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA---- 446
Query: 545 PISDFLTLHSIIISLVEAGAHTDMTNKQNKTPL 577
+ L ++ L+E GA+ + N + TPL
Sbjct: 447 -CGGHVELAAL---LIERGANLEEVNDEGYTPL 475
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,984,595
Number of Sequences: 37866
Number of extensions: 929849
Number of successful extensions: 6417
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 319
Number of HSP's successfully gapped in prelim test: 54
Number of HSP's that attempted gapping in prelim test: 1948
Number of HSP's gapped (non-prelim): 2298
length of query: 627
length of database: 18,247,518
effective HSP length: 108
effective length of query: 519
effective length of database: 14,157,990
effective search space: 7347996810
effective search space used: 7347996810
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.