Search of human proteins with 71773106

Search of human proteins with 71773106

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|71773106 adaptor-related protein complex 2, beta 1 subunit
isoform a [Homo sapiens]
         (951 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|71773106 adaptor-related protein complex 2, beta 1 subunit is...  1881   0.0  
gi|4557469 adaptor-related protein complex 2, beta 1 subunit iso...  1843   0.0  
gi|22027651 adaptor-related protein complex 1 beta 1 subunit iso...  1569   0.0  
gi|22027653 adaptor-related protein complex 1 beta 1 subunit iso...  1563   0.0  
gi|166197671 adaptor-related protein complex 4, beta 1 subunit [...   301   1e-81
gi|34482047 adaptor-related protein complex 3, beta 2 subunit [H...   280   6e-75
gi|32484979 adaptor-related protein complex 3, beta 1 subunit [H...   270   5e-72
gi|27477041 adaptor-related protein complex 2, alpha 2 subunit [...    96   2e-19
gi|19913416 adaptor-related protein complex 2, alpha 1 subunit i...    91   5e-18
gi|19913414 adaptor-related protein complex 2, alpha 1 subunit i...    89   3e-17
gi|117553580 adaptor-related protein complex 3, delta 1 subunit ...    88   3e-17
gi|221316632 coatomer protein complex, subunit beta 1 [Homo sapi...    79   2e-14
gi|221316630 coatomer protein complex, subunit beta 1 [Homo sapi...    79   2e-14
gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens]     79   2e-14
gi|71772942 adaptor-related protein complex 1, gamma 1 subunit i...    78   4e-14
gi|71773010 adaptor-related protein complex 1, gamma 1 subunit i...    76   2e-13
gi|109134349 coatomer protein complex, subunit gamma 2 [Homo sap...    65   2e-10
gi|11559929 coatomer protein complex, subunit gamma 1 [Homo sapi...    62   2e-09
gi|37675283 adaptor-related protein complex 4, epsilon 1 subunit...    60   7e-09
gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [H...    54   5e-07
gi|117553584 adaptor-related protein complex 3, delta 1 subunit ...    50   8e-06
gi|7662228 synaptosomal-associated protein, 91kDa homolog [Homo ...    39   0.030
gi|91984781 ArfGAP with FG repeats 2 [Homo sapiens]                    37   0.11 
gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]         36   0.20 
gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]        36   0.20 
gi|156104874 envoplakin [Homo sapiens]                                 35   0.25 
gi|157694494 MYB binding protein 1a isoform 1 [Homo sapiens]           35   0.33 
gi|157694492 MYB binding protein 1a isoform 2 [Homo sapiens]           35   0.33 
gi|45356151 non-SMC condensin II complex, subunit D3 [Homo sapiens]    35   0.43 
gi|44680122 tripartite motif-containing 7 isoform 1 [Homo sapiens]     34   0.57 

>gi|71773106 adaptor-related protein complex 2, beta 1 subunit
           isoform a [Homo sapiens]
          Length = 951

 Score = 1881 bits (4873), Expect = 0.0
 Identities = 951/951 (100%), Positives = 951/951 (100%)

Query: 1   MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT 60
           MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT
Sbjct: 1   MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT 60

Query: 61  DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120
           DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE
Sbjct: 61  DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120

Query: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA 180
           YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA
Sbjct: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA 180

Query: 181 VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI 240
           VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI
Sbjct: 181 VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI 240

Query: 241 CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY 300
           CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY
Sbjct: 241 CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY 300

Query: 301 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360
           VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE
Sbjct: 301 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360

Query: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK 420
           YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK
Sbjct: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK 420

Query: 421 YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480
           YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV
Sbjct: 421 YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480

Query: 481 QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV 540
           QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV
Sbjct: 481 QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV 540

Query: 541 VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST 600
           VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST
Sbjct: 541 VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST 600

Query: 601 DAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGL 660
           DAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGL
Sbjct: 601 DAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGL 660

Query: 661 DSLLGSDLGGGIGGSPAVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGG 720
           DSLLGSDLGGGIGGSPAVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGG
Sbjct: 661 DSLLGSDLGGGIGGSPAVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGG 720

Query: 721 YVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIP 780
           YVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIP
Sbjct: 721 YVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIP 780

Query: 781 STPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLF 840
           STPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLF
Sbjct: 781 STPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLF 840

Query: 841 VEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDM 900
           VEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDM
Sbjct: 841 VEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDM 900

Query: 901 LYQSLKLTNGIWILAELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN 951
           LYQSLKLTNGIWILAELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN
Sbjct: 901 LYQSLKLTNGIWILAELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN 951


>gi|4557469 adaptor-related protein complex 2, beta 1 subunit
           isoform b [Homo sapiens]
          Length = 937

 Score = 1843 bits (4775), Expect = 0.0
 Identities = 937/951 (98%), Positives = 937/951 (98%), Gaps = 14/951 (1%)

Query: 1   MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT 60
           MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT
Sbjct: 1   MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT 60

Query: 61  DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120
           DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE
Sbjct: 61  DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120

Query: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA 180
           YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA
Sbjct: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA 180

Query: 181 VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI 240
           VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI
Sbjct: 181 VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI 240

Query: 241 CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY 300
           CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY
Sbjct: 241 CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY 300

Query: 301 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360
           VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE
Sbjct: 301 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360

Query: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK 420
           YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK
Sbjct: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK 420

Query: 421 YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480
           YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV
Sbjct: 421 YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480

Query: 481 QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV 540
           QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV
Sbjct: 481 QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV 540

Query: 541 VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST 600
           VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST
Sbjct: 541 VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST 600

Query: 601 DAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGL 660
           DAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGL
Sbjct: 601 DAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGL 660

Query: 661 DSLLGSDLGGGIGGSPAVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGG 720
           DSL              VGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGG
Sbjct: 661 DSL--------------VGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGG 706

Query: 721 YVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIP 780
           YVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIP
Sbjct: 707 YVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIP 766

Query: 781 STPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLF 840
           STPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLF
Sbjct: 767 STPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLF 826

Query: 841 VEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDM 900
           VEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDM
Sbjct: 827 VEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDM 886

Query: 901 LYQSLKLTNGIWILAELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN 951
           LYQSLKLTNGIWILAELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN
Sbjct: 887 LYQSLKLTNGIWILAELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN 937


>gi|22027651 adaptor-related protein complex 1 beta 1 subunit
           isoform a [Homo sapiens]
          Length = 949

 Score = 1569 bits (4062), Expect = 0.0
 Identities = 797/957 (83%), Positives = 874/957 (91%), Gaps = 14/957 (1%)

Query: 1   MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT 60
           MTDSKYFTT KKGEIFELKAELN++KKEK+KEAVKKVIA+MTVGKDVS+LFPDVVNCMQT
Sbjct: 1   MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQT 60

Query: 61  DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120
           DNLELKKLVYLYLMNYAKSQPDMAIMAVN+FVKDCEDPNPLIRALAVRTMGCIRVDKITE
Sbjct: 61  DNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120

Query: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA 180
           YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQ+VEDQGFLD+L+DLI+DSNPMVVANA
Sbjct: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA 180

Query: 181 VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI 240
           VAALSEI+ESHP+SNLLDLNPQ+INKLLTALNECTEWGQIFILDCL+NY PKDDREAQSI
Sbjct: 181 VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSI 240

Query: 241 CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY 300
           CERVTPRLSHANSAVVLSAVKVLMKF+E+L KD DYY  LLKKLAPPLVTLLS EPE+QY
Sbjct: 241 CERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQY 300

Query: 301 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360
           VALRNINLIVQKRPEILK E+KVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE
Sbjct: 301 VALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360

Query: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK 420
           YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVI+DIFRK
Sbjct: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRK 420

Query: 421 YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480
           YPNKYES+IATLCENLDSLDEP+ARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV
Sbjct: 421 YPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480

Query: 481 QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV 540
           QL LLTAIVKLFLKKP+ETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPV AKEV
Sbjct: 481 QLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEV 540

Query: 541 VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST 600
           VL+EKPLISEETDLIEPTLLDELIC+IG+LASVYHKPP+AFVEG  G+  K LP    S+
Sbjct: 541 VLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASS 600

Query: 601 DAGDSP-VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQV--SSMQMGAVDLLG 657
           ++ +SP    T A   EQP VIP+QGDLLGDLLNLDLGPPV+ P +  SS+QMGAVDLLG
Sbjct: 601 ESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLG 660

Query: 658 GGLDSLLGSDLGGGIGGSPAVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMA 717
           GGLDSL+G D   GIGG+  V       + P    P+   A + SGL+DLF+L++G+G  
Sbjct: 661 GGLDSLMG-DEPEGIGGTNFV-------APPTAAVPANLGAPIGSGLSDLFDLTSGVGTL 712

Query: 718 PGGYVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFG 777
            G YVAPKAVWLPA+KAKGLEISGTFT + G I M++  TNKALQ MTDFAIQFN+NSFG
Sbjct: 713 SGSYVAPKAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFG 772

Query: 778 VIPSTPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLN 837
           + P+TPL +H PL PNQ++++SLPL+T+G VMKMEPLNNLQVAVKNNIDVFYFS L PL+
Sbjct: 773 LAPATPLQVHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLH 832

Query: 838 VLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEG 897
           +LFVEDGKM+RQ+FLATWKDIPNENE QFQI++C LNA+  SSKLQ++N++T+AKRNVEG
Sbjct: 833 ILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEG 892

Query: 898 QDMLYQSLKLTNGIWILAELRIQPGNPNYT---LSLKCRAPEVSQYIYQVYDSILKN 951
           QDMLYQSLKLTNGIW+LAELRIQPGNP+ T   LSLKCRAPEVSQ++YQ Y++ILKN
Sbjct: 893 QDMLYQSLKLTNGIWVLAELRIQPGNPSCTDLELSLKCRAPEVSQHVYQAYETILKN 949


>gi|22027653 adaptor-related protein complex 1 beta 1 subunit
           isoform b [Homo sapiens]
          Length = 942

 Score = 1563 bits (4048), Expect = 0.0
 Identities = 793/957 (82%), Positives = 871/957 (91%), Gaps = 21/957 (2%)

Query: 1   MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT 60
           MTDSKYFTT KKGEIFELKAELN++KKEK+KEAVKKVIA+MTVGKDVS+LFPDVVNCMQT
Sbjct: 1   MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQT 60

Query: 61  DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120
           DNLELKKLVYLYLMNYAKSQPDMAIMAVN+FVKDCEDPNPLIRALAVRTMGCIRVDKITE
Sbjct: 61  DNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120

Query: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA 180
           YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQ+VEDQGFLD+L+DLI+DSNPMVVANA
Sbjct: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA 180

Query: 181 VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI 240
           VAALSEI+ESHP+SNLLDLNPQ+INKLLTALNECTEWGQIFILDCL+NY PKDDREAQSI
Sbjct: 181 VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSI 240

Query: 241 CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY 300
           CERVTPRLSHANSAVVLSAVKVLMKF+E+L KD DYY  LLKKLAPPLVTLLS EPE+QY
Sbjct: 241 CERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQY 300

Query: 301 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360
           VALRNINLIVQKRPEILK E+KVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE
Sbjct: 301 VALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360

Query: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK 420
           YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVI+DIFRK
Sbjct: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRK 420

Query: 421 YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480
           YPNKYES+IATLCENLDSLDEP+ARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV
Sbjct: 421 YPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480

Query: 481 QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV 540
           QL LLTAIVKLFLKKP+ETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPV AKEV
Sbjct: 481 QLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEV 540

Query: 541 VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST 600
           VL+EKPLISEETDLIEPTLLDELIC+IG+LASVYHKPP+AFVEG  G+  K LP    S+
Sbjct: 541 VLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASS 600

Query: 601 DAGDSP-VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQV--SSMQMGAVDLLG 657
           ++ +SP    T A   EQP VIP+QGDLLGDLLNLDLGPPV+ P +  SS+QMGAVDLLG
Sbjct: 601 ESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLG 660

Query: 658 GGLDSLLGSDLGGGIGGSPAVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMA 717
           GGLDSL+G             G +F+  + P    P+   A + SGL+DLF+L++G+G  
Sbjct: 661 GGLDSLIG-------------GTNFV--APPTAAVPANLGAPIGSGLSDLFDLTSGVGTL 705

Query: 718 PGGYVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFG 777
            G YVAPKAVWLPA+KAKGLEISGTFT + G I M++  TNKALQ MTDFAIQFN+NSFG
Sbjct: 706 SGSYVAPKAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFG 765

Query: 778 VIPSTPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLN 837
           + P+TPL +H PL PNQ++++SLPL+T+G VMKMEPLNNLQVAVKNNIDVFYFS L PL+
Sbjct: 766 LAPATPLQVHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLH 825

Query: 838 VLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEG 897
           +LFVEDGKM+RQ+FLATWKDIPNENE QFQI++C LNA+  SSKLQ++N++T+AKRNVEG
Sbjct: 826 ILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEG 885

Query: 898 QDMLYQSLKLTNGIWILAELRIQPGNPNYT---LSLKCRAPEVSQYIYQVYDSILKN 951
           QDMLYQSLKLTNGIW+LAELRIQPGNP+ T   LSLKCRAPEVSQ++YQ Y++ILKN
Sbjct: 886 QDMLYQSLKLTNGIWVLAELRIQPGNPSCTDLELSLKCRAPEVSQHVYQAYETILKN 942


>gi|166197671 adaptor-related protein complex 4, beta 1 subunit
           [Homo sapiens]
          Length = 739

 Score =  301 bits (772), Expect = 1e-81
 Identities = 184/619 (29%), Positives = 325/619 (52%), Gaps = 18/619 (2%)

Query: 17  ELKAELNNEKKE----KRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLY 72
           ELK  L N   +    + +  +++VI  MT G D+S +F ++V    T ++  KKLVYLY
Sbjct: 12  ELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVYLY 71

Query: 73  LMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKD 132
           +  YA  +PD+A++A+N+  KDC DPNP++R LA+R+M  +R+  + EY+ +P+   L+D
Sbjct: 72  MCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRD 131

Query: 133 EDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHP 192
           +  YVR+ A +  AK+H+++     D   ++ L  L+ D +P+VV N + +L EI +   
Sbjct: 132 KASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEG 191

Query: 193 NSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHAN 252
               + +N    + LL  +++  +WGQ  +L+ L  Y P+ + E   I   +   L  ++
Sbjct: 192 G---VVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLLDSFLKSSS 248

Query: 253 SAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQK 312
             VV+ A K+ +   ++ P      ++L++   P L    S   E+ +VAL ++  I+  
Sbjct: 249 PGVVMGATKLFLILAKMFPHVQT--DVLVRVKGPLLAACSSESRELCFVALCHVRQILHS 306

Query: 313 RPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRK 372
            P       K FF  Y++P Y+KL+K++++  L +  N+ QVL EL+ Y T+V  DF + 
Sbjct: 307 LPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQA 366

Query: 373 AVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATL 432
           A+ AIG  A       ++CV  L +L+  +  ++    +   RD+    P   E++   L
Sbjct: 367 AIFAIGGIA---RTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQAL 423

Query: 433 CENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDES-TQVQLTLLTAIVKL 491
               +++ + + + A+IW++G + ERI NA  +LE F+E    E+   V++ LLTA+++L
Sbjct: 424 PGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTALLRL 483

Query: 492 FLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEK--PLIS 549
           FL +P+E Q+++ ++L    ++  +  +RDRG  Y+RLL       K ++ S K  P + 
Sbjct: 484 FLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDPTLG 543

Query: 550 EETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGT 609
              D  E   ++       +L  VY K   A +    G  R    +   S+ A   P+  
Sbjct: 544 LLEDPAERP-VNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL-- 600

Query: 610 TTATNLEQPQVIPSQGDLL 628
               N E+ Q +P  G L+
Sbjct: 601 IPEENKERVQELPDSGALM 619



 Score = 30.8 bits (68), Expect = 6.3
 Identities = 24/95 (25%), Positives = 41/95 (43%), Gaps = 2/95 (2%)

Query: 838 VLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEG 897
           ++ V + ++    F  TW  +   ++ Q        + DT+   LQ  N+ TIA      
Sbjct: 618 LMLVPNRQLTADYFEKTWLSLKVAHQ-QVLPWRGEFHPDTLQMALQVVNIQTIAMSRAGS 676

Query: 898 QDM-LYQSLKLTNGIWILAELRIQPGNPNYTLSLK 931
           +    Y S +   G   L EL ++PGN    +S+K
Sbjct: 677 RPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVK 711


>gi|34482047 adaptor-related protein complex 3, beta 2 subunit [Homo
           sapiens]
          Length = 1082

 Score =  280 bits (715), Expect = 6e-75
 Identities = 188/621 (30%), Positives = 313/621 (50%), Gaps = 75/621 (12%)

Query: 17  ELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNY 76
           +LK  L+  K   + EA+K+++A +  GK+ S LFP VV  +   N+E+KKLVY+YL+ Y
Sbjct: 41  DLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRY 100

Query: 77  AKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPY 136
           A+ Q D+A++++++F +  +DPN LIRA A+R +  IRV  I   +   +++   D  PY
Sbjct: 101 AEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPY 160

Query: 137 VRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNL 196
           VRKTAA  + KL+ +++   +DQ  ++ +  L+AD   +V  + V A  E+         
Sbjct: 161 VRKTAAHAIPKLYSLDSDQ-KDQ-LIEVIEKLLADKTTLVAGSVVMAFEEVCPER----- 213

Query: 197 LDLNPQNINKLLTALNECTEWGQIFILDCLSNY-------------------------NP 231
           +DL  +N  KL   L +  EWGQ+ I+  L+ Y                         + 
Sbjct: 214 IDLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENAEKAFYGSE 273

Query: 232 KDDREAQSICE----------------------RVTPRLSHANSAVVLSAVKVLMKFLEL 269
           +D+ +     E                      R T  L  + SA V+ AV  L  +  L
Sbjct: 274 EDEAKGAGSEETAAAAAPSRKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQL--YFHL 331

Query: 270 LPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYN 329
            PK        +  +A  LV LL    EVQYV L+N+  +  KR  + +  +K F+++  
Sbjct: 332 APKAE------VGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIRST 385

Query: 330 DPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAE 389
           DP  +K+ KL+++  LA++ NI  VL E + Y   +D DFV   ++AIGRCA  + +  +
Sbjct: 386 DPTQIKILKLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRD 445

Query: 390 RCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMI 449
            C++ L+ L+  +   VV E++VVI+ + +  P ++  II  L +  D++  P ARA+++
Sbjct: 446 TCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASIL 505

Query: 450 WIVGEYAERIDN-ADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLS 508
           W++GEY E +   A ++L    + F  E   V+L ++    KL+L    +T+ L Q VLS
Sbjct: 506 WLIGEYCEHVPRIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLS 565

Query: 509 LATQDSDNPDLRDRGYIYWRLLSTDPV------TAKEVVLSEKPLISEETDLIEPTLLDE 562
           LA  D  N D+RDR     +L+            AK++ L+ KP       ++E +  D 
Sbjct: 566 LAKYD-QNYDIRDRARFTRQLIVPSEQGGALSRHAKKLFLAPKP-----APVLESSFKDR 619

Query: 563 LICHIGSLASVYHKPPNAFVE 583
               +GSL+ + +     + E
Sbjct: 620 DHFQLGSLSHLLNAKATGYQE 640


>gi|32484979 adaptor-related protein complex 3, beta 1 subunit [Homo
           sapiens]
          Length = 1094

 Score =  270 bits (690), Expect = 5e-72
 Identities = 179/621 (28%), Positives = 314/621 (50%), Gaps = 69/621 (11%)

Query: 11  KKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVY 70
           KK E  +LK  L + K   + +A+K+++  +  GK+ S LFP VV  + + N+E+KKLVY
Sbjct: 42  KKNE--DLKQMLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVY 99

Query: 71  LYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
           +YL+ YA+ Q D+A++++++F +  +DPN LIRA A+R +  IRV  I   +   +++  
Sbjct: 100 VYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAS 159

Query: 131 KDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISES 190
            D  PYVRK AA  + KL+ ++ +  E    ++ +  L+ D + +V  + V A  E+   
Sbjct: 160 ADLSPYVRKNAAHAIQKLYSLDPEQKEM--LIEVIEKLLKDKSTLVAGSVVMAFEEVCPD 217

Query: 191 HPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNY--------------------- 229
                 +DL  +N  KL   L +  EWGQ+ I+  L+ Y                     
Sbjct: 218 R-----IDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPWKEGDELEDNGKN 272

Query: 230 --NPKDDREAQS---------------ICERVTPRLSHANSAVVLSAVKVLMKFLELLPK 272
                DD++ ++               +     P L   N+AVV++  ++   +  + PK
Sbjct: 273 FYESDDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQL---YWHISPK 329

Query: 273 DSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYNDPI 332
                      ++  LV LL    EVQY+ L+NI  +  +R  + +  +K F+V+  DP 
Sbjct: 330 SEAGI------ISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPT 383

Query: 333 YVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCV 392
            +K  KL+I+  LA++ANI+ +L E + Y    D  F    ++ IGRCA  + +  + C+
Sbjct: 384 MIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCL 443

Query: 393 STLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIV 452
           + L+ L+  +   VV E++VVI+ + +  P ++  II  + + LDS+  P ARA+++W++
Sbjct: 444 NGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLI 503

Query: 453 GEYAERIDN-ADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLAT 511
           GE  ER+   A ++L    + F  E   V+L +L    KL+L    +T+ L Q +L+L  
Sbjct: 504 GENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLGK 563

Query: 512 QDSDNPDLRDRGYIYWRLLSTDPVT------AKEVVLSEKPLISEETDLIEPTLLDELIC 565
            D  N D+RDR     +L+  +  +      AK++ L++KP       L+E    D    
Sbjct: 564 YD-QNYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKP-----APLLESPFKDRDHF 617

Query: 566 HIGSLASVYHKPPNAFVEGSH 586
            +G+L+   +     ++E S+
Sbjct: 618 QLGTLSHTLNIKATGYLELSN 638


>gi|27477041 adaptor-related protein complex 2, alpha 2 subunit
           [Homo sapiens]
          Length = 939

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 127/596 (21%), Positives = 247/596 (41%), Gaps = 59/596 (9%)

Query: 10  NKKGEIFELKAELNNEKKE----------KRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQ 59
           +K+ EI  +  EL N + +           +K+ V K++    +G D+     + VN + 
Sbjct: 25  SKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLS 84

Query: 60  TDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKIT 119
           ++    K++ YL++     S  ++  +  N+   D    NP    LA+  +  +   ++ 
Sbjct: 85  SNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMA 144

Query: 120 EYLCEPLRKCLKDEDPY--VRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVV 177
           E     + K L   D    V+++AA+C+ +L+  +  +V    +   +  L+ D +  VV
Sbjct: 145 EAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHLLNDQHLGVV 204

Query: 178 ANAVAALSEISESHPN--SNLLDLNPQNINKLLTA----LNECT------EWGQIFILDC 225
             A + ++ +++ +P      + L    +++++T+    L + T       W  + +L  
Sbjct: 205 TAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRL 264

Query: 226 LSNYNPKDDREAQSICERVTPRLSHANSAVVLSAVK-------VLMKFLELLPKDSDYYN 278
           L  Y P D      + E +   L+ A        V+       VL + + L+       N
Sbjct: 265 LQCYPPPDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPN 324

Query: 279 MLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKR--PEILKQEIKVFF--VKYNDPIYV 334
           +L++        L   E  ++Y+AL ++  +       E +K  I+     +K    + V
Sbjct: 325 LLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSV 384

Query: 335 KLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVST 394
           +   +D++  +  ++N  Q++AE+  Y    D     + V  +   A K        V T
Sbjct: 385 RQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDT 444

Query: 395 LLDLIQTKVNYVVQEA------IVVIRDIFRKYPNK--YESIIATLC-ENLDSLDEPDAR 445
           +L+LI+   +YV +E       IV+ RD  + Y  K  +E++ A  C ENL  +      
Sbjct: 445 ILNLIRIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGG---- 500

Query: 446 AAMIWIVGEYAERI---DNADELLESFL--EGFHDESTQVQLTLLTAIVKLFLKKPSETQ 500
               +I+GE+   I     +  L++  L    FH  S   +  LL+  +K F+    E +
Sbjct: 501 ----YILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALLLSTYIK-FVNLFPEVK 555

Query: 501 ELVQQVLSLATQ-DSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEKPLISEETDLI 555
             +Q VL   +Q  + + +L+ R   Y RL +         VL E P   E    I
Sbjct: 556 PTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSI 611


>gi|19913416 adaptor-related protein complex 2, alpha 1 subunit
           isoform 2 [Homo sapiens]
          Length = 955

 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 203/1008 (20%), Positives = 392/1008 (38%), Gaps = 155/1008 (15%)

Query: 10  NKKGEIFELKAELNNEKKE----------KRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQ 59
           +K+ EI  +  EL N + +           +K+ V K++    +G D+     + VN + 
Sbjct: 25  SKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLS 84

Query: 60  TDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKIT 119
           ++    K++ YL++     S  ++  +  N+   D    NP    LA+  +  +   ++ 
Sbjct: 85  SNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHCIANVGSREMG 144

Query: 120 EYLCEPLRKCL--KDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVV 177
           E     + + L   D    V+++AA+C+ +L+  +  +V    +   +  L+ D +  VV
Sbjct: 145 EAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLLNDQHMGVV 204

Query: 178 ANAVAALSEISESHPN--SNLLDLNPQNINKLL----TALNECT------EWGQIFILDC 225
             AV+ ++ + + +P+     + L    +++++    T L + T       W  + +L  
Sbjct: 205 TAAVSLITCLCKKNPDDFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSVKLLRL 264

Query: 226 LSNYNPKDD---------------REAQSICERVTPRLSHANSAVVLSAVKVLMKFLELL 270
           L  Y P +D                +AQ   +    + S+A +A++   + +++ +    
Sbjct: 265 LQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFETISLIIHY---- 320

Query: 271 PKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKR--PEILKQEIKVFF--V 326
             DS+  N+L++        L   E  ++Y+AL ++  +       E +K  I      +
Sbjct: 321 --DSE-PNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINAL 377

Query: 327 KYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQ 386
           K    + V+    D++  +  ++N  Q+++E+  Y    D     + V  +   A K   
Sbjct: 378 KTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAEKYAV 437

Query: 387 SAERCVSTLLDLIQTKVNYVVQEA------IVVIRDIFRKYPNK--YESIIATLC-ENLD 437
                V T+L+LI+   +YV +E       IV  RD  + Y  K  +E++ A  C EN+ 
Sbjct: 438 DYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDDVQGYAAKTVFEALQAPACHENMV 497

Query: 438 SLDEPDARAAMIWIVGEYAERI----DNADELLESFLEG-FHDESTQVQLTLLTAIVKLF 492
            +          +I+GE+   I     ++  +  S L   FH  S   +  LL+  +K F
Sbjct: 498 KVGG--------YILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRALLLSTYIK-F 548

Query: 493 LKKPSETQELVQQVLSLATQ-DSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEKPLISEE 551
           +    ET+  +Q VL   +Q  + + +L+ R   Y  L S         VL E P   E 
Sbjct: 549 INLFPETKATIQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPER 608

Query: 552 TDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGTTT 611
              I   L  +     GS      + P++                    + G  P  +T 
Sbjct: 609 ESSILAKLKRKKGPGAGSALDDGRRDPSS-----------------NDINGGMEPTPSTV 651

Query: 612 ATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLLGSDLGGG 671
           +T        PS      DLL L   PP   P  S+   GA +LL          D+  G
Sbjct: 652 ST--------PSPS---ADLLGLRAAPPPAAPPASA---GAGNLL---------VDVFDG 688

Query: 672 IGGSPAVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLPA 731
               P++G +      P     SP P  +   + +  EL         G +    +    
Sbjct: 689 PAAQPSLGPT------PEEAFLSPGPEDIGPPIPEADELLNKFVCKNNGVLFENQLLQIG 742

Query: 732 VKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIP----STPLAIH 787
           VK++       F    G +Y  + + NK        ++QF   S  V+      T LA+ 
Sbjct: 743 VKSE-------FRQNLGRMY--LFYGNKT-------SVQFQNFSPTVVHPGDLQTQLAVQ 786

Query: 788 TPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFY------FSCLIPLNV-LF 840
           T  +  Q +D    +     V+ +E L +       ++   Y       +  +P+ +  F
Sbjct: 787 TKRVAAQ-VDGGAQVQ---QVLNIECLRDFLTPPLLSVRFRYGGAPQALTLKLPVTINKF 842

Query: 841 VEDGKMERQVFLATWKDIP-NENELQFQIKECH-LNADTVSSKLQNNNVYTIAKRNVEGQ 898
            +  +M  Q F   WK +   + E Q   K  H ++A+   +KL       +   +   +
Sbjct: 843 FQPTEMAAQDFFQRWKQLSLPQQEAQKIFKANHPMDAEVTKAKLLGFGSALLDNVDPNPE 902

Query: 899 DMLYQSLKLTNGIWILAELRIQPG--NPNYTLSLKCRAPEVSQYIYQV 944
           + +   +  T  + +   LR++P      Y L+L+     VS+++ ++
Sbjct: 903 NFVGAGIIQTKALQVGCLLRLEPNAQAQMYRLTLRTSKEPVSRHLCEL 950


>gi|19913414 adaptor-related protein complex 2, alpha 1 subunit
           isoform 1 [Homo sapiens]
          Length = 977

 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 206/1020 (20%), Positives = 400/1020 (39%), Gaps = 157/1020 (15%)

Query: 10  NKKGEIFELKAELNNEKKE----------KRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQ 59
           +K+ EI  +  EL N + +           +K+ V K++    +G D+     + VN + 
Sbjct: 25  SKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLS 84

Query: 60  TDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKIT 119
           ++    K++ YL++     S  ++  +  N+   D    NP    LA+  +  +   ++ 
Sbjct: 85  SNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHCIANVGSREMG 144

Query: 120 EYLCEPLRKCL--KDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVV 177
           E     + + L   D    V+++AA+C+ +L+  +  +V    +   +  L+ D +  VV
Sbjct: 145 EAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLLNDQHMGVV 204

Query: 178 ANAVAALSEISESHPN--SNLLDLNPQNINKLL----TALNECT------EWGQIFILDC 225
             AV+ ++ + + +P+     + L    +++++    T L + T       W  + +L  
Sbjct: 205 TAAVSLITCLCKKNPDDFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSVKLLRL 264

Query: 226 LSNYNPKDD---------------REAQSICERVTPRLSHANSAVVLSAVKVLMKFLELL 270
           L  Y P +D                +AQ   +    + S+A +A++   + +++ +    
Sbjct: 265 LQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFETISLIIHY---- 320

Query: 271 PKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKR--PEILKQEIKVFF--V 326
             DS+  N+L++        L   E  ++Y+AL ++  +       E +K  I      +
Sbjct: 321 --DSE-PNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINAL 377

Query: 327 KYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQ 386
           K    + V+    D++  +  ++N  Q+++E+  Y    D     + V  +   A K   
Sbjct: 378 KTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAEKYAV 437

Query: 387 SAERCVSTLLDLIQTKVNYVVQEA------IVVIRDIFRKYPNK--YESIIATLC-ENLD 437
                V T+L+LI+   +YV +E       IV  RD  + Y  K  +E++ A  C EN+ 
Sbjct: 438 DYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDDVQGYAAKTVFEALQAPACHENMV 497

Query: 438 SLDEPDARAAMIWIVGEYAERI----DNADELLESFLEG-FHDESTQVQLTLLTAIVKLF 492
            +          +I+GE+   I     ++  +  S L   FH  S   +  LL+  +K F
Sbjct: 498 KVGG--------YILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRALLLSTYIK-F 548

Query: 493 LKKPSETQELVQQVLSLATQ-DSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEKPLISEE 551
           +    ET+  +Q VL   +Q  + + +L+ R   Y  L S         VL E P   E 
Sbjct: 549 INLFPETKATIQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPER 608

Query: 552 TDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGTTT 611
              I   L  +     GS      + P++                    + G  P  +T 
Sbjct: 609 ESSILAKLKRKKGPGAGSALDDGRRDPSS-----------------NDINGGMEPTPSTV 651

Query: 612 ATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLLGSDLGGG 671
           +T        PS      DLL L   PP   P  S+   GA +LL   +D   G      
Sbjct: 652 ST--------PSPS---ADLLGLRAAPPPAAPPASA---GAGNLL---VDVFDGPAAQPS 694

Query: 672 IGGSPAVGQSFI----------PSSVPATFAPS--PTPAVVSSGLNDLFELSTGIGMAPG 719
           +G +P   ++F+          P ++ A  AP+  P P  +   + +  EL         
Sbjct: 695 LGPTPE--EAFLSELEPPAPESPMALLADPAPAADPGPEDIGPPIPEADELLNKFVCKNN 752

Query: 720 GYVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVI 779
           G +    +    VK++       F    G +Y  + + NK        ++QF   S  V+
Sbjct: 753 GVLFENQLLQIGVKSE-------FRQNLGRMY--LFYGNKT-------SVQFQNFSPTVV 796

Query: 780 P----STPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFY------ 829
                 T LA+ T  +  Q +D    +     V+ +E L +       ++   Y      
Sbjct: 797 HPGDLQTQLAVQTKRVAAQ-VDGGAQVQ---QVLNIECLRDFLTPPLLSVRFRYGGAPQA 852

Query: 830 FSCLIPLNV-LFVEDGKMERQVFLATWKDIP-NENELQFQIKECH-LNADTVSSKLQNNN 886
            +  +P+ +  F +  +M  Q F   WK +   + E Q   K  H ++A+   +KL    
Sbjct: 853 LTLKLPVTINKFFQPTEMAAQDFFQRWKQLSLPQQEAQKIFKANHPMDAEVTKAKLLGFG 912

Query: 887 VYTIAKRNVEGQDMLYQSLKLTNGIWILAELRIQPG--NPNYTLSLKCRAPEVSQYIYQV 944
              +   +   ++ +   +  T  + +   LR++P      Y L+L+     VS+++ ++
Sbjct: 913 SALLDNVDPNPENFVGAGIIQTKALQVGCLLRLEPNAQAQMYRLTLRTSKEPVSRHLCEL 972


>gi|117553580 adaptor-related protein complex 3, delta 1 subunit
           isoform 2 [Homo sapiens]
          Length = 1153

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 97/478 (20%), Positives = 198/478 (41%), Gaps = 32/478 (6%)

Query: 15  IFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLM 74
           I E+K EL  +    +  AV K+     +G D+S    +++  M       K++ YL   
Sbjct: 40  IDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAAS 99

Query: 75  NYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDED 134
                  D+ ++  N   KD   P+     +A+  + C     +   L   +   +    
Sbjct: 100 QSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTK 159

Query: 135 PYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNS 194
           PY+RK A + + K+     + +        L++ + D +P V + AV  + E++  +P  
Sbjct: 160 PYIRKKAVLIMYKVFLKYPESLRPA--FPRLKEKLEDPDPGVQSAAVNVICELARRNP-K 216

Query: 195 NLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHANSA 254
           N L L P     + ++ N    W  I I+       P + R  + + E +T  L H+ SA
Sbjct: 217 NYLSLAPLFFKLMTSSTN---NWVLIKIIKLFGALTPLEPRLGKKLIEPLT-NLIHSTSA 272

Query: 255 VVL------SAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINL 308
           + L      + + VL+     +P  S    + ++KL    + +   +  ++Y+ L  ++ 
Sbjct: 273 MSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLR---ILIEDSDQNLKYLGLLAMSK 329

Query: 309 IVQKRPEILKQEIKVFFVKYND-PIYVKLEKLDIMIRLASQANIAQVLAEL-----KEYA 362
           I++  P+ ++    +     +D    ++L  LD++  + S+ N+ +++ +L     K   
Sbjct: 330 ILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEG 389

Query: 363 TEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQ---TKVNYVV--QEAIVVIR-D 416
           T    + + K +    +   +   + E  +S L++L +   T+  +++  Q   V IR  
Sbjct: 390 TTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVK 449

Query: 417 IFRKYPNKYESIIATLCENLDSLDEP----DARAAMIWIVGEYAERIDNADELLESFL 470
             RK+     S +      L S  +     +   A  WI GE++E +      LE+ L
Sbjct: 450 AIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAML 507


>gi|221316632 coatomer protein complex, subunit beta 1 [Homo
           sapiens]
          Length = 953

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 122/622 (19%), Positives = 244/622 (39%), Gaps = 105/622 (16%)

Query: 18  LKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVN-CMQTDNLELKKLVYLYLMNY 76
           LK +L     + + EA+KKVI  +  G+ +  L   ++   +   +  +KKL+ ++    
Sbjct: 26  LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85

Query: 77  AKSQPD-----MAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131
            K+ PD       I+  +++ KD + PN  IR   +R +  ++  ++ E L   +R CL+
Sbjct: 86  PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145

Query: 132 DEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRD-LIADSNPMVVANAVAALSEISES 190
               YVR+ A + +  ++     ++ D   L  + D L+ + +     NA   L    + 
Sbjct: 146 HRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IHDFLVNEKDASCKRNAFMMLIHADQD 203

Query: 191 HPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSH 250
                      + ++ L T +++   +G I                 Q +   +  ++ H
Sbjct: 204 -----------RALDYLSTCIDQVQTFGDIL----------------QLVIVELIYKVCH 236

Query: 251 ANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQ-----YVAL-- 303
           AN +     ++ +   L+       Y      + A  LVTL S    ++     Y+ L  
Sbjct: 237 ANPSERARFIRCIYNLLQSSSPAVKY------EAAGTLVTLSSAPTAIKAAAQCYIDLII 290

Query: 304 ----RNINLIVQKRPEILKQE-----------IKVFFVKYNDPIYVKLEKLDIMIRLASQ 348
                N+ LIV  R   LK+            + +  V     + V+ + L + + L S 
Sbjct: 291 KESDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSS 350

Query: 349 ANIAQVLAELKEYATEV-------DVDFVRK-AVRAIGRCAIKVEQSAERCVSTLLDLIQ 400
            N+ +++  LK+   +        D D  R+  VR +  C+++    A   +  L++ + 
Sbjct: 351 RNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLS 410

Query: 401 TKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERID 460
                   + +  +R+  +++ N    I+  + E   ++         +WI+GEY     
Sbjct: 411 DNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYC---- 466

Query: 461 NADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQELVQQVLSLATQ-- 512
           +  E ++S +        ++ +       +    KP E       Q+LV ++ + ATQ  
Sbjct: 467 STKEDIQSVMTEIRRSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSA 526

Query: 513 ---------DSDNPDLR----DRGYIYWRLLSTDPVTAKEVVLSEKPLISEE----TDLI 555
                    + D P LR    D  +     L+T   T  ++ L    L+ E+    + + 
Sbjct: 527 LSSSRPTKKEEDRPPLRGFLLDGDFFVAASLAT---TLTKIALRYVALVQEKKKQNSFVA 583

Query: 556 EPTLLDELICHIGSLASVYHKP 577
           E  LL   I H+G  +S+  KP
Sbjct: 584 EAMLLMATILHLGK-SSLPKKP 604


>gi|221316630 coatomer protein complex, subunit beta 1 [Homo
           sapiens]
          Length = 953

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 122/622 (19%), Positives = 244/622 (39%), Gaps = 105/622 (16%)

Query: 18  LKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVN-CMQTDNLELKKLVYLYLMNY 76
           LK +L     + + EA+KKVI  +  G+ +  L   ++   +   +  +KKL+ ++    
Sbjct: 26  LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85

Query: 77  AKSQPD-----MAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131
            K+ PD       I+  +++ KD + PN  IR   +R +  ++  ++ E L   +R CL+
Sbjct: 86  PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145

Query: 132 DEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRD-LIADSNPMVVANAVAALSEISES 190
               YVR+ A + +  ++     ++ D   L  + D L+ + +     NA   L    + 
Sbjct: 146 HRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IHDFLVNEKDASCKRNAFMMLIHADQD 203

Query: 191 HPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSH 250
                      + ++ L T +++   +G I                 Q +   +  ++ H
Sbjct: 204 -----------RALDYLSTCIDQVQTFGDIL----------------QLVIVELIYKVCH 236

Query: 251 ANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQ-----YVAL-- 303
           AN +     ++ +   L+       Y      + A  LVTL S    ++     Y+ L  
Sbjct: 237 ANPSERARFIRCIYNLLQSSSPAVKY------EAAGTLVTLSSAPTAIKAAAQCYIDLII 290

Query: 304 ----RNINLIVQKRPEILKQE-----------IKVFFVKYNDPIYVKLEKLDIMIRLASQ 348
                N+ LIV  R   LK+            + +  V     + V+ + L + + L S 
Sbjct: 291 KESDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSS 350

Query: 349 ANIAQVLAELKEYATEV-------DVDFVRK-AVRAIGRCAIKVEQSAERCVSTLLDLIQ 400
            N+ +++  LK+   +        D D  R+  VR +  C+++    A   +  L++ + 
Sbjct: 351 RNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLS 410

Query: 401 TKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERID 460
                   + +  +R+  +++ N    I+  + E   ++         +WI+GEY     
Sbjct: 411 DNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYC---- 466

Query: 461 NADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQELVQQVLSLATQ-- 512
           +  E ++S +        ++ +       +    KP E       Q+LV ++ + ATQ  
Sbjct: 467 STKEDIQSVMTEIRRSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSA 526

Query: 513 ---------DSDNPDLR----DRGYIYWRLLSTDPVTAKEVVLSEKPLISEE----TDLI 555
                    + D P LR    D  +     L+T   T  ++ L    L+ E+    + + 
Sbjct: 527 LSSSRPTKKEEDRPPLRGFLLDGDFFVAASLAT---TLTKIALRYVALVQEKKKQNSFVA 583

Query: 556 EPTLLDELICHIGSLASVYHKP 577
           E  LL   I H+G  +S+  KP
Sbjct: 584 EAMLLMATILHLGK-SSLPKKP 604


>gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens]
          Length = 953

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 122/622 (19%), Positives = 244/622 (39%), Gaps = 105/622 (16%)

Query: 18  LKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVN-CMQTDNLELKKLVYLYLMNY 76
           LK +L     + + EA+KKVI  +  G+ +  L   ++   +   +  +KKL+ ++    
Sbjct: 26  LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85

Query: 77  AKSQPD-----MAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131
            K+ PD       I+  +++ KD + PN  IR   +R +  ++  ++ E L   +R CL+
Sbjct: 86  PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145

Query: 132 DEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRD-LIADSNPMVVANAVAALSEISES 190
               YVR+ A + +  ++     ++ D   L  + D L+ + +     NA   L    + 
Sbjct: 146 HRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IHDFLVNEKDASCKRNAFMMLIHADQD 203

Query: 191 HPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSH 250
                      + ++ L T +++   +G I                 Q +   +  ++ H
Sbjct: 204 -----------RALDYLSTCIDQVQTFGDIL----------------QLVIVELIYKVCH 236

Query: 251 ANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQ-----YVAL-- 303
           AN +     ++ +   L+       Y      + A  LVTL S    ++     Y+ L  
Sbjct: 237 ANPSERARFIRCIYNLLQSSSPAVKY------EAAGTLVTLSSAPTAIKAAAQCYIDLII 290

Query: 304 ----RNINLIVQKRPEILKQE-----------IKVFFVKYNDPIYVKLEKLDIMIRLASQ 348
                N+ LIV  R   LK+            + +  V     + V+ + L + + L S 
Sbjct: 291 KESDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSS 350

Query: 349 ANIAQVLAELKEYATEV-------DVDFVRK-AVRAIGRCAIKVEQSAERCVSTLLDLIQ 400
            N+ +++  LK+   +        D D  R+  VR +  C+++    A   +  L++ + 
Sbjct: 351 RNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLS 410

Query: 401 TKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERID 460
                   + +  +R+  +++ N    I+  + E   ++         +WI+GEY     
Sbjct: 411 DNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYC---- 466

Query: 461 NADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQELVQQVLSLATQ-- 512
           +  E ++S +        ++ +       +    KP E       Q+LV ++ + ATQ  
Sbjct: 467 STKEDIQSVMTEIRRSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSA 526

Query: 513 ---------DSDNPDLR----DRGYIYWRLLSTDPVTAKEVVLSEKPLISEE----TDLI 555
                    + D P LR    D  +     L+T   T  ++ L    L+ E+    + + 
Sbjct: 527 LSSSRPTKKEEDRPPLRGFLLDGDFFVAASLAT---TLTKIALRYVALVQEKKKQNSFVA 583

Query: 556 EPTLLDELICHIGSLASVYHKP 577
           E  LL   I H+G  +S+  KP
Sbjct: 584 EAMLLMATILHLGK-SSLPKKP 604


>gi|71772942 adaptor-related protein complex 1, gamma 1 subunit
           isoform b [Homo sapiens]
          Length = 822

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 145/676 (21%), Positives = 273/676 (40%), Gaps = 76/676 (11%)

Query: 66  KKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEP 125
           K++ YL  M     + D+ ++  N    D       ++ LA+ T+GC+   ++   L   
Sbjct: 82  KRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGE 141

Query: 126 LRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALS 185
           + K LK  + Y+RK AA+C   +H I       + FL + ++L+ + N  V+  +V  L+
Sbjct: 142 VEKLLKTSNSYLRKKAALCA--VHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLT 199

Query: 186 EISESHPN--SNLLDLNPQNINKLLTALNE-----------CTEWGQIFILDCLSNYNPK 232
           E+ E  P+  ++   L PQ +  L   +                + Q+ IL  L      
Sbjct: 200 EMCERSPDMLAHFRKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRILGRN 259

Query: 233 DDREAQSICERV------TPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAP 286
           DD  ++++ + +      T    +  +A++   V  +M     +  +S    + +  L  
Sbjct: 260 DDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMD----IKSESGLRVLAINILGR 315

Query: 287 PLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYND-PIYVKLEKLDIMIRL 345
               LL+ +  ++YVAL ++   VQ     +++          D  + +K   +++   L
Sbjct: 316 ---FLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFAL 372

Query: 346 ASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNY 405
            +  NI  ++ EL  +    + +F       I   A K   S    + T++ ++ T  +Y
Sbjct: 373 VNGNNIRGMMKELLYFLDSCEPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSY 432

Query: 406 VVQEAIVVIRDIFRKYPNKYESIIATLCENL--DSLDEPDARAAMIWIVGEYAERI---- 459
           V  +A+  +  +       +   +  L + +  D   +P  + A  W +GEY + +    
Sbjct: 433 VRDDAVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVA-AWCIGEYGDLLVSGQ 491

Query: 460 -----------DNADELLESFLEGFHDESTQV-QLTLLTAIVKLFLKKPSETQELVQQVL 507
                      D   ++LES L    + ST V +   LTAI+KL  +    T   +++V+
Sbjct: 492 CEEEEPIQVTEDEVLDILESVL--ISNMSTSVTRGYALTAIMKLSTRFTC-TVNRIKKVV 548

Query: 508 SLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEKPLISEETDLIEPTLLDELICHI 567
           S+     D  +L+ R   Y  L            L E+  + E+     PT   E++   
Sbjct: 549 SIYGSSID-VELQQRAVEYNALFK--KYDHMRSALLERMPVMEKVTTNGPT---EIVQTN 602

Query: 568 GSL--ASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGTTTATNLEQPQVIPSQG 625
           G    A +  KPP +  + +   +   L +  G+      P   T+  +    +++    
Sbjct: 603 GETEPAPLETKPPPSGPQPTSQAN-DLLDLLGGNDITPVIPTAPTSKPSSAGGELL---- 657

Query: 626 DLLGDLLNLDLGP-----PVNVPQVSSMQMGAVDLLGGGLDSLLGSDLGGGIGGSPAVGQ 680
           DLLGD +NL   P     P +VPQ+S        LL G     L +D+  GI    A  +
Sbjct: 658 DLLGD-INLTGAPAAAPAPASVPQISQPPF----LLDGLSSQPLFNDIAAGIPSITAYSK 712

Query: 681 SFIPSSVPATFAPSPT 696
           + +   +  TF  S T
Sbjct: 713 NGL--KIEFTFERSNT 726


>gi|71773010 adaptor-related protein complex 1, gamma 1 subunit
           isoform a [Homo sapiens]
          Length = 825

 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 145/679 (21%), Positives = 272/679 (40%), Gaps = 79/679 (11%)

Query: 66  KKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEP 125
           K++ YL  M     + D+ ++  N    D       ++ LA+ T+GC+   ++   L   
Sbjct: 82  KRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGE 141

Query: 126 LRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALS 185
           + K LK  + Y+RK AA+C   +H I       + FL + ++L+ + N  V+  +V  L+
Sbjct: 142 VEKLLKTSNSYLRKKAALCA--VHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLT 199

Query: 186 EISESHPNSNL-LDLNPQNINKLLTALNECTEWG---------------QIFILDCLSNY 229
           E+ E  P+       N + + +L+  L      G               Q+ IL  L   
Sbjct: 200 EMCERSPDMLAHFRKNEKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRIL 259

Query: 230 NPKDDREAQSICERV------TPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKK 283
              DD  ++++ + +      T    +  +A++   V  +M     +  +S    + +  
Sbjct: 260 GRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMD----IKSESGLRVLAINI 315

Query: 284 LAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYND-PIYVKLEKLDIM 342
           L      LL+ +  ++YVAL ++   VQ     +++          D  + +K   +++ 
Sbjct: 316 LGR---FLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELS 372

Query: 343 IRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTK 402
             L +  NI  ++ EL  +    + +F       I   A K   S    + T++ ++ T 
Sbjct: 373 FALVNGNNIRGMMKELLYFLDSCEPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTA 432

Query: 403 VNYVVQEAIVVIRDIFRKYPNKYESIIATLCENL--DSLDEPDARAAMIWIVGEYAERI- 459
            +YV  +A+  +  +       +   +  L + +  D   +P  + A  W +GEY + + 
Sbjct: 433 GSYVRDDAVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVA-AWCIGEYGDLLV 491

Query: 460 --------------DNADELLESFLEGFHDESTQV-QLTLLTAIVKLFLKKPSETQELVQ 504
                         D   ++LES L    + ST V +   LTAI+KL  +    T   ++
Sbjct: 492 SGQCEEEEPIQVTEDEVLDILESVL--ISNMSTSVTRGYALTAIMKLSTRFTC-TVNRIK 548

Query: 505 QVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEKPLISEETDLIEPTLLDELI 564
           +V+S+     D  +L+ R   Y  L            L E+  + E+     PT   E++
Sbjct: 549 KVVSIYGSSID-VELQQRAVEYNALFK--KYDHMRSALLERMPVMEKVTTNGPT---EIV 602

Query: 565 CHIGSL--ASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGTTTATNLEQPQVIP 622
              G    A +  KPP +  + +   +   L +  G+      P   T+  +    +++ 
Sbjct: 603 QTNGETEPAPLETKPPPSGPQPTSQAN-DLLDLLGGNDITPVIPTAPTSKPSSAGGELL- 660

Query: 623 SQGDLLGDLLNLDLGP-----PVNVPQVSSMQMGAVDLLGGGLDSLLGSDLGGGIGGSPA 677
              DLLGD +NL   P     P +VPQ+S        LL G     L +D+  GI    A
Sbjct: 661 ---DLLGD-INLTGAPAAAPAPASVPQISQPPF----LLDGLSSQPLFNDIAAGIPSITA 712

Query: 678 VGQSFIPSSVPATFAPSPT 696
             ++ +   +  TF  S T
Sbjct: 713 YSKNGL--KIEFTFERSNT 729


>gi|109134349 coatomer protein complex, subunit gamma 2 [Homo
           sapiens]
          Length = 871

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 86/493 (17%), Positives = 206/493 (41%), Gaps = 30/493 (6%)

Query: 46  DVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRAL 105
           + +  F  +    Q+++  L+++ YL +   A    D+ I+  +S  KD      + R  
Sbjct: 65  EATEAFFAMTRLFQSNDQTLRRMCYLTIKEMATISEDV-IIVTSSLTKDMTGKEDVYRGP 123

Query: 106 AVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSL 165
           A+R +  I    + + +   +++ + D+   V  +A V    +  I+  +V+   +++  
Sbjct: 124 AIRALCRITDGTMLQAIERYMKQAIVDKVSSVSSSALVSSLHMMKISYDVVKR--WINEA 181

Query: 166 RDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDC 225
           ++  +  N MV  +A+  L  + ++   +    LN    + L +    C     + I   
Sbjct: 182 QEAASSDNIMVQYHALGVLYHLRKNDRLAVSKMLNKFTKSGLKSQFAYC-----MLIRIA 236

Query: 226 LSNYNPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLA 285
                  +D     + + +   L + +  V+  A   ++     LP      N   ++LA
Sbjct: 237 SRLLKETEDGHESPLFDFIESCLRNKHEMVIYEAASAIIH----LP------NCTARELA 286

Query: 286 PPLVTLL----SGEPEVQYVALRNINLIVQKRPEIL---KQEIKVFFVKYNDPIYVKLEK 338
           P +  L     S +P ++Y A+R +N +  K P  +     +++      N  I      
Sbjct: 287 PAVSVLQLFCSSPKPALRYAAVRTLNKVAMKHPSAVTACNLDLENLITDSNRSIATL--A 344

Query: 339 LDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDL 398
           +  +++  S++++ +++ ++  + +E+  +F    V+AI     K  +     ++ L ++
Sbjct: 345 ITTLLKTGSESSVDRLMKQISSFVSEISDEFKVVVVQAISALCQKYPRKHSVMMTFLSNM 404

Query: 399 IQTKVNYVVQEAIV-VIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAE 457
           ++    +  + AIV  I  I  + P   E+ +A LCE ++  +       ++ ++G+   
Sbjct: 405 LRDDGGFEYKRAIVDCIISIVEENPESKEAGLAHLCEFIEDCEHTVLATKILHLLGKEGP 464

Query: 458 RIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNP 517
           R     + +         E+  V+   ++A+ K   +  S    ++  +L     D+D+ 
Sbjct: 465 RTPVPSKYIRFIFNRVVLENEAVRAAAVSALAKFGAQNESLLPSIL-VLLQRCMMDTDD- 522

Query: 518 DLRDRGYIYWRLL 530
           ++RDR   Y  +L
Sbjct: 523 EVRDRATFYLNVL 535


>gi|11559929 coatomer protein complex, subunit gamma 1 [Homo
           sapiens]
          Length = 874

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 90/500 (18%), Positives = 212/500 (42%), Gaps = 44/500 (8%)

Query: 46  DVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRAL 105
           + +  F  +    Q+++  L+++ YL +   +    D+ I+  +S  KD        R  
Sbjct: 65  EATEAFFAMTKLFQSNDPTLRRMCYLTIKEMSCIAEDV-IIVTSSLTKDMTGKEDNYRGP 123

Query: 106 AVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSL 165
           AVR +  I    + + +   +++ + D+ P V  +A   V+ LH +       + +++  
Sbjct: 124 AVRALCQITDSTMLQAIERYMKQAIVDKVPSVSSSA--LVSSLHLLKCSFDVVKRWVNEA 181

Query: 166 RDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNE---CTEWGQIFI 222
           ++  +  N MV  +A+  L  + +   N  L       +NK+++ +      + +    +
Sbjct: 182 QEAASSDNIMVQYHALGLLYHVRK---NDRLA------VNKMISKVTRHGLKSPFAYCMM 232

Query: 223 LDCLSNYNPKDDREAQS-ICERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLL 281
           +   S    ++D    S + + +   L + +  VV  A   ++     LP  S       
Sbjct: 233 IRVASKQLEEEDGSRDSPLFDFIESCLRNKHEMVVYEAASAIVN----LPGCS------A 282

Query: 282 KKLAPPLVTL----LSGEPEVQYVALRNINLIVQKRPEIL---KQEIKVFFVKYNDPIYV 334
           K+LAP +  L     S +  ++Y A+R +N +  K P  +     +++      N  I  
Sbjct: 283 KELAPAVSVLQLFCSSPKAALRYAAVRTLNKVAMKHPSAVTACNLDLENLVTDSNRSIAT 342

Query: 335 KLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVST 394
               +  +++  S+++I +++ ++  + +E+  +F    V+AI     K  +     ++ 
Sbjct: 343 L--AITTLLKTGSESSIDRLMKQISSFMSEISDEFKVVVVQAISALCQKYPRKHAVLMNF 400

Query: 395 LLDLIQTKVNYVVQEAIV-VIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVG 453
           L  +++ +  +  + AIV  I  I  +     E+ ++ LCE ++  +       ++ ++G
Sbjct: 401 LFTMLREEGGFEYKRAIVDCIISIIEENSESKETGLSHLCEFIEDCEFTVLATRILHLLG 460

Query: 454 EYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSL---A 510
           +   +  N  + +         E  +V+   ++A+ K      ++ +E++  +L L    
Sbjct: 461 QEGPKTTNPSKYIRFIYNRVVLEHEEVRAGAVSALAKF----GAQNEEMLPSILVLLKRC 516

Query: 511 TQDSDNPDLRDRGYIYWRLL 530
             D DN ++RDR   Y  +L
Sbjct: 517 VMDDDN-EVRDRATFYLNVL 535


>gi|37675283 adaptor-related protein complex 4, epsilon 1 subunit
           [Homo sapiens]
          Length = 1137

 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 99/467 (21%), Positives = 194/467 (41%), Gaps = 45/467 (9%)

Query: 14  EIFELKAELN--NEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYL 71
           E+  LKA ++      +  KE + ++I    +G D S  +   +   Q  NL  K++ YL
Sbjct: 59  ELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYL 118

Query: 72  YLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131
            +  +     ++ ++ VN+ VKD +  N +   +A+  +  I   ++   +   +   L+
Sbjct: 119 AVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQ 178

Query: 132 DEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAV-AALSEISES 190
                VR+ A + + K H I    V  Q      R  + D +  V+A ++   L  I E+
Sbjct: 179 HSKEIVRRKAVLALYKFHLIAPNQV--QHIHIKFRKALCDRDVGVMAASLHIYLRMIKEN 236

Query: 191 HPNSNLLDLNPQNI--------NKLLTALNECT---EWGQIFILDCLSNYNPKDDREAQS 239
             +S   DL    +         KL    N  +    W QI +L  L      D R ++ 
Sbjct: 237 --SSGYKDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRILGLLGKDDQRTSEL 294

Query: 240 ICERVTPRLSHA---NSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPL-VTLLSGE 295
           + + +   L  A   ++       + +     + PK       LL+K A  +   +LS +
Sbjct: 295 MYDVLDESLRRAELNHNVTYAILFECVHTVYSIYPKSE-----LLEKAAKCIGKFVLSPK 349

Query: 296 PEVQYVALRNINLIVQKRPEILKQEIKVFF--VKYNDPIYVKLEKLDIMIRLASQANIAQ 353
             ++Y+ L+ +  ++Q+ P +  Q        + + DPI +K E L+++ R+ +  NI  
Sbjct: 350 INLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPI-IKRETLELLYRITNAQNITV 408

Query: 354 VLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVV 413
           ++ ++ EY  +   ++V   V  +G    K+ + AE+        IQT     +     V
Sbjct: 409 IVQKMLEYLHQSKEEYV--IVNLVG----KIAELAEKYAPDNAWFIQT-----MNAVFSV 457

Query: 414 IRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERID 460
             D+   +P+   + +  L E  D  DE + +   ++ V  Y   +D
Sbjct: 458 GGDVM--HPDIPNNFLRLLAEGFD--DETEDQQLRLYAVQSYLTLLD 500


>gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [Homo
           sapiens]
          Length = 785

 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 93/493 (18%), Positives = 191/493 (38%), Gaps = 41/493 (8%)

Query: 66  KKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEP 125
           K++ YL  M     + D  ++  NS   D       ++ LA+ T+  +   ++   L   
Sbjct: 83  KRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLSTMGSAEMCRDLAPE 142

Query: 126 LRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALS 185
           + K L    PYVRK A   +  +H I         FL     L+ + +  ++   +  ++
Sbjct: 143 VEKLLLQPSPYVRKKA--ILTAVHMIRKVPELSSVFLPPCAQLLHERHHGILLGTITLIT 200

Query: 186 EISESHPNS--NLLDLNPQ--NINKLLTALNECTEWG---------QIFILDCLSNYNPK 232
           E+ E  P +  +   + PQ  +I + L  +   TE           Q+ IL  L      
Sbjct: 201 ELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPFLQVQILRLLRILGRN 260

Query: 233 DDREAQSICERV------TPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAP 286
            +  ++++ + +      T    +A +AV+   V  +M             N+L +    
Sbjct: 261 HEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDIRSAAGLRVLAVNILGR---- 316

Query: 287 PLVTLLSGEPEVQYVALRNINLIVQK-RPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRL 345
               LL+ +  ++YVAL ++  +VQ     + +    V          +    L++ + L
Sbjct: 317 ---FLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASLSRRALELSLAL 373

Query: 346 ASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNY 405
            + +N+  ++ EL+ +      D        I   A +   +    + T+L ++ T   +
Sbjct: 374 VNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKRWHIDTILHVLTTAGTH 433

Query: 406 VVQEAIVVIRDIFRKYPNKYESIIATLCENL--DSLDEPDARAAMIWIVGEYAERI--DN 461
           V  +A+  +  +       +   +  L   L  D   +P  + A  W +GEY + +   N
Sbjct: 434 VRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPLVQVA-AWCIGEYGDLLLAGN 492

Query: 462 ADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQ-DSDNPDLR 520
            +E     +E    +  +V L LL  +++  +  P+     +  ++ L+T+   DN  +R
Sbjct: 493 CEE-----IEPLQVDEEEV-LALLEKVLQSHMSLPATRGYALTALMKLSTRLCGDNNRIR 546

Query: 521 DRGYIYWRLLSTD 533
               IY   L  +
Sbjct: 547 QVVSIYGSCLDVE 559


>gi|117553584 adaptor-related protein complex 3, delta 1 subunit
           isoform 1 [Homo sapiens]
          Length = 1112

 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 43/207 (20%), Positives = 76/207 (36%), Gaps = 27/207 (13%)

Query: 15  IFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLM 74
           I E+K EL  +    +  AV K+     +G D+S    +++  M       K++ YL   
Sbjct: 40  IDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAAS 99

Query: 75  NYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDED 134
                  D+ ++  N   KD   P+     +A+  + C     +   L   +   +    
Sbjct: 100 QSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTK 159

Query: 135 PYVRKTA---------------------------AVCVAKLHDINAQMVEDQGFLDSLRD 167
           PY+RK A                           AV ++    +       Q  +  LR 
Sbjct: 160 PYIRKKAKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRI 219

Query: 168 LIADSNPMVVANAVAALSEISESHPNS 194
           LI DS+  +    + A+S+I ++HP S
Sbjct: 220 LIEDSDQNLKYLGLLAMSKILKTHPKS 246



 Score = 37.0 bits (84), Expect = 0.088
 Identities = 54/271 (19%), Positives = 120/271 (44%), Gaps = 27/271 (9%)

Query: 222 ILDCLSNYNPKDDREAQSICERVTPRLSHANSAVVL------SAVKVLMKFLELLPKDSD 275
           I+  +S+  P   ++A+ I E +T  L H+ SA+ L      + + VL+     +P  S 
Sbjct: 151 IMTLMSHTKPYIRKKAKLI-EPLT-NLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSA 208

Query: 276 YYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYNDPIY-V 334
              + ++KL    + +   +  ++Y+ L  ++ I++  P+ ++    +     +D    +
Sbjct: 209 SIQLCVQKLR---ILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESI 265

Query: 335 KLEKLDIMIRLASQANIAQVLAEL-----KEYATEVDVDFVRKAVRAIGRCAIKVEQSAE 389
           +L  LD++  + S+ N+ +++ +L     K   T    + + K +    +   +   + E
Sbjct: 266 RLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFE 325

Query: 390 RCVSTLLDLIQ---TKVNYVV--QEAIVVIR-DIFRKYPNKYESIIATLCENLDSLDEPD 443
             +S L++L +   T+  +++  Q   V IR    RK+     S +      L S  + +
Sbjct: 326 WYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRN 385

Query: 444 ARAAMI----WIVGEYAERIDNADELLESFL 470
               ++    WI GE++E +      LE+ L
Sbjct: 386 GICEVLYAAAWICGEFSEHLQEPHHTLEAML 416


>gi|7662228 synaptosomal-associated protein, 91kDa homolog [Homo
           sapiens]
          Length = 907

 Score = 38.5 bits (88), Expect = 0.030
 Identities = 51/199 (25%), Positives = 75/199 (37%), Gaps = 28/199 (14%)

Query: 574 YHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGTTTATNLEQPQVIPSQG--DLLGDL 631
           +  PP    +G+  +    L     S DA  +P   TTA+    P  + S G  DL GD 
Sbjct: 594 FSSPP----QGASPVPESSLTADLLSVDAFAAPSPATTAS----PAKVDSSGVIDLFGDA 645

Query: 632 LNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLLGSDLGGGIGGSPAVGQSFIPS------ 685
                  P    Q +S    + DLL G   S +          +PA      P+      
Sbjct: 646 FGSSASEPQPASQAASSSSASADLLAGFGGSFMAPSPS---PVTPAQNNLLQPNFEAAFG 702

Query: 686 SVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLP-----AVKAKGLEIS 740
           + P+T + S     V  GL DL   +    MAP G  AP ++  P     A KA G ++ 
Sbjct: 703 TTPSTSSSSSFDPSVFDGLGDLLMPT----MAPAGQPAPVSMVPPSPAMAASKALGSDLD 758

Query: 741 GTFTHRQGHIYMEMNFTNK 759
            +     G++ +    T K
Sbjct: 759 SSLASLVGNLGISGTTTKK 777


>gi|91984781 ArfGAP with FG repeats 2 [Homo sapiens]
          Length = 481

 Score = 36.6 bits (83), Expect = 0.11
 Identities = 39/135 (28%), Positives = 54/135 (40%), Gaps = 7/135 (5%)

Query: 594 PIHHGSTDAGDSPVGTTTATNLEQPQVIP-SQGDLLGDLLNLDLGPPVNVPQVSSMQMGA 652
           P    S  A  +P G++  T      + P SQ + L D+ +  LGP V    V S   G 
Sbjct: 279 PAGQASFQAQPTPAGSSQGTPFGATPLAPASQPNSLADVGSF-LGPGVPAAGVPSSLFG- 336

Query: 653 VDLLGGGLDSLLGSDLGGGIGGSPAVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELST 712
              + G +  L    +GGG G S  +      +   A  A SP P+      N L     
Sbjct: 337 ---MAGQVPPLQSVTMGGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAP-GP 392

Query: 713 GIGMAPGGYVAPKAV 727
           G GM+  G   P+AV
Sbjct: 393 GFGMSSAGPGFPQAV 407


>gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]
          Length = 509

 Score = 35.8 bits (81), Expect = 0.20
 Identities = 38/177 (21%), Positives = 78/177 (44%), Gaps = 15/177 (8%)

Query: 52  PDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFV----------KDCEDPNPL 101
           P +V C+Q   + LK++    L + AK  P++A   V++             D +  + +
Sbjct: 170 PLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQI 229

Query: 102 IRALAVRTMGCIRV-DKITEYLCEPL-RKCLKDEDPYVRKTAAVC---VAKLHDINAQMV 156
           + AL+  +   + + + + E    P+   CLKD+D YV+K A+     +AK     +Q+V
Sbjct: 230 LSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLV 289

Query: 157 EDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNE 213
            + G + ++ D I           +  L  ++    N  +  +  + + +L   L+E
Sbjct: 290 VNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSE 346


>gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]
          Length = 458

 Score = 35.8 bits (81), Expect = 0.20
 Identities = 38/177 (21%), Positives = 78/177 (44%), Gaps = 15/177 (8%)

Query: 52  PDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFV----------KDCEDPNPL 101
           P +V C+Q   + LK++    L + AK  P++A   V++             D +  + +
Sbjct: 170 PLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQI 229

Query: 102 IRALAVRTMGCIRV-DKITEYLCEPL-RKCLKDEDPYVRKTAAVC---VAKLHDINAQMV 156
           + AL+  +   + + + + E    P+   CLKD+D YV+K A+     +AK     +Q+V
Sbjct: 230 LSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLV 289

Query: 157 EDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNE 213
            + G + ++ D I           +  L  ++    N  +  +  + + +L   L+E
Sbjct: 290 VNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSE 346


>gi|156104874 envoplakin [Homo sapiens]
          Length = 2033

 Score = 35.4 bits (80), Expect = 0.25
 Identities = 84/410 (20%), Positives = 157/410 (38%), Gaps = 57/410 (13%)

Query: 132  DEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSE----I 187
            +ED   RK A   VAKL          Q  ++ L   I+   P V+   V  + +    +
Sbjct: 1100 EEDAARRKQAEEAVAKL----------QARIEDLERAISSVEPKVIVKEVKKVEQDPGLL 1149

Query: 188  SESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPR 247
             ES   S L  L  +   K  T   E +        D  S Y+  + +  +   +     
Sbjct: 1150 QES---SRLRSLLEEERTKNATLARELS--------DLHSKYSVVEKQRPKVQLQERVHE 1198

Query: 248  LSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNIN 307
            +   +        ++  K  E+  K S     + +KL P L  L + +P V+Y  +    
Sbjct: 1199 IFQVDPETEQEITRLKAKLQEMAGKRSGVEKEV-EKLLPDLEVLRAQKPTVEYKEVTQEV 1257

Query: 308  LIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQAN--------------IAQ 353
            +  ++ PE+L+ EI     + N+ +       + +IRL  + +                +
Sbjct: 1258 VRHERSPEVLR-EIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKE 1316

Query: 354  VLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVS--TLLDLIQTKVNYVVQEAI 411
            V+   K+   E + + +R+ VR   +     E +     S   LL+  + +   VVQE +
Sbjct: 1317 VVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVV 1376

Query: 412  VVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLE 471
            V  +D       K     + L  +LD  +E   R  +   V +    ++  + LL    +
Sbjct: 1377 VTQKD------PKLREEHSRLSGSLD--EEVGRRRQLELEVQQLRAGVEEQEGLLSFQED 1428

Query: 472  GFHDESTQVQLTLLTAIVKLFLKKPSETQE--LVQQVLSLATQDSDNPDL 519
                 + + +L  LT  ++   K+P   QE  ++++V+ L      +PDL
Sbjct: 1429 RSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKL----EKDPDL 1474


>gi|157694494 MYB binding protein 1a isoform 1 [Homo sapiens]
          Length = 1332

 Score = 35.0 bits (79), Expect = 0.33
 Identities = 33/117 (28%), Positives = 54/117 (46%), Gaps = 18/117 (15%)

Query: 261 KVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQE 320
           + LMK ++LL   + Y N L ++    LV +LS   EV    L+ I       PE+LK +
Sbjct: 154 EALMKSVKLLQALAQYQNHLQEQPRKALVDILS---EVSKATLQEI------LPEVLKAD 204

Query: 321 IKV---------FFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVD 368
           + +          F+     +  KL+KL   + L S  N+ +++  LK  A+ V  D
Sbjct: 205 LNIILSSPEQLELFLLAQQKVPSKLKKLVGSVNLFSDENVPRLVNVLKMAASSVKKD 261


>gi|157694492 MYB binding protein 1a isoform 2 [Homo sapiens]
          Length = 1328

 Score = 35.0 bits (79), Expect = 0.33
 Identities = 33/117 (28%), Positives = 54/117 (46%), Gaps = 18/117 (15%)

Query: 261 KVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQE 320
           + LMK ++LL   + Y N L ++    LV +LS   EV    L+ I       PE+LK +
Sbjct: 154 EALMKSVKLLQALAQYQNHLQEQPRKALVDILS---EVSKATLQEI------LPEVLKAD 204

Query: 321 IKV---------FFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVD 368
           + +          F+     +  KL+KL   + L S  N+ +++  LK  A+ V  D
Sbjct: 205 LNIILSSPEQLELFLLAQQKVPSKLKKLVGSVNLFSDENVPRLVNVLKMAASSVKKD 261


>gi|45356151 non-SMC condensin II complex, subunit D3 [Homo sapiens]
          Length = 1498

 Score = 34.7 bits (78), Expect = 0.43
 Identities = 27/102 (26%), Positives = 49/102 (48%), Gaps = 8/102 (7%)

Query: 82   DMAIMAVNSFVKD---CEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVR 138
            D+A  ++ + V++   CED       + V    CIR   + +     +  CLKD DP++R
Sbjct: 936  DLAKKSIPALVRELEVCEDVAVRNNVIIVMCDLCIRYTIMVDKYIPNISMCLKDSDPFIR 995

Query: 139  KTAAVCVAKLHDINAQMVEDQG--FLDSLRDLIADSNPMVVA 178
            K   + +  L  +  + V+ +G  F   +  LI DS+P + +
Sbjct: 996  KQTLILLTNL--LQEEFVKWKGSLFFRFVSTLI-DSHPDIAS 1034


>gi|44680122 tripartite motif-containing 7 isoform 1 [Homo sapiens]
          Length = 511

 Score = 34.3 bits (77), Expect = 0.57
 Identities = 41/188 (21%), Positives = 74/188 (39%), Gaps = 36/188 (19%)

Query: 210 ALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHAN---SAVVLSAVKVLMKF 266
           A   C + G+ F L C       D R    +C+R      HA       V  A ++L   
Sbjct: 126 AAARCGQHGEPFKLYCQD-----DGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESR 180

Query: 267 LELLPK---DSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKV 323
           L +L K   D + +    KK +  L+  ++ E               Q++     Q ++ 
Sbjct: 181 LRVLKKELEDCEVFRSTEKKESKELLKQMAAE---------------QEKVGAEFQALRA 225

Query: 324 FFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAEL----------KEYATEVDVDFVRKA 373
           F V+    +  +LE+L   +      N+AQ+  E+          +E A + D+DF+++ 
Sbjct: 226 FLVEQEGRLLGRLEELSREVAQKQNENLAQLGVEITQLSKLSSQIQETAQKPDLDFLQEF 285

Query: 374 VRAIGRCA 381
              + RC+
Sbjct: 286 KSTLSRCS 293


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,619,586
Number of Sequences: 37866
Number of extensions: 1603386
Number of successful extensions: 5150
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 5002
Number of HSP's gapped (non-prelim): 128
length of query: 951
length of database: 18,247,518
effective HSP length: 112
effective length of query: 839
effective length of database: 14,006,526
effective search space: 11751475314
effective search space used: 11751475314
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.