Search of human proteins with 70995130

Search of human proteins with 70995130

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
[Homo sapiens]
         (479 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   979   0.0  
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   496   e-140
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    338   8e-93
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   322   5e-88
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   316   3e-86
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   310   2e-84
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   306   2e-83
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   295   6e-80
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   293   3e-79
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   288   1e-77
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   286   3e-77
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     280   3e-75
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   275   5e-74
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   244   2e-64
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   234   2e-61
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   230   2e-60
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              229   4e-60
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   217   2e-56
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   214   2e-55
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   214   2e-55
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   200   3e-51
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              177   2e-44
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   169   7e-42
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   162   5e-40
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   144   1e-34
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p...    88   2e-17
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso...    87   3e-17
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is...    87   3e-17
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]        86   1e-16
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]          86   1e-16

>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  979 bits (2531), Expect = 0.0
 Identities = 479/479 (100%), Positives = 479/479 (100%)

Query: 1   MNWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTL 60
           MNWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTL
Sbjct: 1   MNWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTL 60

Query: 61  QITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLY 120
           QITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLY
Sbjct: 61  QITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLY 120

Query: 121 NKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNG 180
           NKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNG
Sbjct: 121 NKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNG 180

Query: 181 NQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFY 240
           NQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFY
Sbjct: 181 NQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFY 240

Query: 241 IVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIG 300
           IVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIG
Sbjct: 241 IVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIG 300

Query: 301 KYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLS 360
           KYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLS
Sbjct: 301 KYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLS 360

Query: 361 PHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQ 420
           PHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQ
Sbjct: 361 PHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQ 420

Query: 421 YKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD 479
           YKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD
Sbjct: 421 YKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD 479


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  496 bits (1278), Expect = e-140
 Identities = 250/453 (55%), Positives = 322/453 (71%), Gaps = 28/453 (6%)

Query: 26  ADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQ 85
           A+G+ A KLF DLF +Y++ALRPV DTD+ LNVTL++TLSQI DMDERNQ+LT YLWIRQ
Sbjct: 25  AEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQ 84

Query: 86  IWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITW 145
            W DAYL WD + Y GLD+IRIPS LVWRPDIVLYNKAD +     +TNVVLR+DG + W
Sbjct: 85  EWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRW 144

Query: 146 DAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEV 205
           DAPAIT+SSC VDV  FPFD Q C LTFGSWT+ G+Q+D+     +  L+DF+E+VEW V
Sbjct: 145 DAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRV 204

Query: 206 HGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAAS 265
            GMPA + V++YGCCSEPYPDVTFTLLL+RR++ Y+ NLL+PCVLIS LAPL+F+LPA S
Sbjct: 205 LGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADS 264

Query: 266 GEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHF 325
           GEKVSLGVT+LLA+TVFQL++AE MP +E+VPLIGKYY+ATM ++T STALTI++MN+H+
Sbjct: 265 GEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHY 324

Query: 326 CGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAA 385
           CG   RPVP WAR ++L +++R L V + GE C     SR  +      S  P+S     
Sbjct: 325 CGPSVRPVPAWARALLLGHLARGLCVRERGEPC---GQSRPPE-----LSPSPQSP---- 372

Query: 386 RNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKCLKDHKATNSKG 445
                          +   G       E    C Q + L  ++  IA   + H+A     
Sbjct: 373 ---------------EGGAGPPAGPCHEPRCLCRQ-EALLHHVATIANTFRSHRAAQRCH 416

Query: 446 SEWKKVAKVIDRFFMWIFFIMVFVMTILIIARA 478
            +WK++A+V+DRFF+ IFF M  VM++L++ +A
Sbjct: 417 EDWKRLARVMDRFFLAIFFSMALVMSLLVLVQA 449


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  338 bits (866), Expect = 8e-93
 Identities = 162/444 (36%), Positives = 264/444 (59%), Gaps = 13/444 (2%)

Query: 32  QKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAY 91
           ++LF+ LF  Y+  +RPVE+    + V  ++ ++Q+ ++DE NQI+   LW+R IW+D  
Sbjct: 35  ERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYK 94

Query: 92  LTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAIT 151
           L WD  +YDG++++R+P+D +W+PDIVLYN A  +      T  +L+Y+G+ITW  PAI 
Sbjct: 95  LRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIF 154

Query: 152 KSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAV 211
           KSSC +D+T+FPFD+Q C+L FGSWTY+  ++D+       D++DF E+ EWE+      
Sbjct: 155 KSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASGY 214

Query: 212 KNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSL 271
           K+ I Y CC E Y D+T++  ++R   FY +NL+IPC+ ISFL  L FYLP+  GEKV+L
Sbjct: 215 KHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTL 274

Query: 272 GVTILLAMTVFQLMVAEIMPA-SENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEA 330
            +++LL++TVF L++ E +P+ S  VPL+G+Y + TM  +T S  +T+ V+NIH+     
Sbjct: 275 CISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTT 334

Query: 331 RPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAARNKDL 390
             +P W + V LK + +VL +       L        D + +  ++ P     A+  +  
Sbjct: 335 HTMPRWVKTVFLKLLPQVLLM----RWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPR 390

Query: 391 SRKKDMNKRLKNDLGCQGKNPQ--------EAESYCAQYKVLTRNIEYIAKCLKDHKATN 442
             K+  +    N+L    +           E   +  + + +  ++++IA+ +K H  T 
Sbjct: 391 HLKECFHCHKSNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETK 450

Query: 443 SKGSEWKKVAKVIDRFFMWIFFIM 466
               +WK VA V+DR F+W+F I+
Sbjct: 451 EVEDDWKYVAMVVDRVFLWVFIIV 474


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  322 bits (825), Expect = 5e-88
 Identities = 179/497 (36%), Positives = 276/497 (55%), Gaps = 45/497 (9%)

Query: 12  WIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMD 71
           W+  AAS L  +    G++ +KL+ +L ++Y+   RPV +  + L V   ++L QI D+D
Sbjct: 9   WLALAASLLHVS--LQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVD 66

Query: 72  ERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPV 131
           E+NQ+LT  +W++  W D YL W+  +Y G+ ++R P   +W+PDI+LYN AD+      
Sbjct: 67  EKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATF 126

Query: 132 NTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDS 191
           +TNV++   G   +  P I KSSC +DV +FPFD Q C L FGSW+Y G  +D+   +  
Sbjct: 127 HTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL--QMQE 184

Query: 192 GDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLI 251
            D+S +I + EW++ G+P  ++   Y CC EPYPDVTFT+ ++RR+ +Y +NLLIPCVLI
Sbjct: 185 ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLI 244

Query: 252 SFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPA-SENVPLIGKYYIATMALI 310
           S LA L F LPA SGEK+SLG+T+LL++TVF L+VAEIMPA S++VPLI +Y+ +TM ++
Sbjct: 245 SALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIV 304

Query: 311 TASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSP--HHSRERD 368
             S  +T++V+  H    +   +P W RV++L + +  L +   GE  + P   H + R 
Sbjct: 305 GLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRC 364

Query: 369 HLTKVYSK---------------------------LPESNLKAARNKDLSRKKDMNKRLK 401
            L  V                               P+S +   R   ++     ++ L 
Sbjct: 365 SLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGR---MACSPTHDEHL- 420

Query: 402 NDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMW 461
                 G  P E +   A+   +   + YIA   +    + +  SEWK  A V+DR  + 
Sbjct: 421 ----LHGGQPPEGDPDLAK---ILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLM 473

Query: 462 IFFIMVFVMTILIIARA 478
            F +   + TI I+  A
Sbjct: 474 AFSVFTIICTIGILMSA 490


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  316 bits (809), Expect = 3e-86
 Identities = 168/471 (35%), Positives = 268/471 (56%), Gaps = 20/471 (4%)

Query: 18  SRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQIL 77
           S L  A  ++ ++  +LF  LFEDY+  +RPV +    + +  ++++SQ+  +DE NQI+
Sbjct: 24  SLLPVARASEAEH--RLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIM 81

Query: 78  TAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVL 137
              LW++QIW+D  L W+   Y G + +R+P+  +W+PDIVLYN A  +      T  +L
Sbjct: 82  ETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALL 141

Query: 138 RYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDF 197
           +Y G +TW  PAI KSSC +DVTYFPFD Q C + FGSW+Y+  ++D+     S +L D+
Sbjct: 142 KYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDY 201

Query: 198 IEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPL 257
            E  EW +   P  K+ I Y CC E YPD+T++L ++R   FY +NL+IPC+LISFL  L
Sbjct: 202 WESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVL 261

Query: 258 SFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENV-PLIGKYYIATMALITASTAL 316
            FYLP+  GEKV+L +++LL++TVF L++ E +P++  V PLIG+Y + TM  +T S  +
Sbjct: 262 VFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVI 321

Query: 317 TIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFV-----YDVGESCLSPHHSRERDHLT 371
           T+ V+N+H+       +P W + V L  + RV+F+      +       P +  E  +L 
Sbjct: 322 TVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNL- 380

Query: 372 KVYSKLPESNLKAARN-KDLSRKKDMNKRLK-NDLGCQGKNPQEAESYCA---------Q 420
             +S+      K     +D       ++R+K ++          +ES  A         +
Sbjct: 381 NCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPE 440

Query: 421 YKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMT 471
            K   ++++YIA+ +K          +WK VA VIDR F+W+F ++  + T
Sbjct: 441 IKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGT 491


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  310 bits (794), Expect = 2e-84
 Identities = 169/460 (36%), Positives = 260/460 (56%), Gaps = 23/460 (5%)

Query: 33  KLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYL 92
           +LF  LF  Y+   RPV +T  V+ V   ++++Q+ D+DE+NQ++T  +W++Q W D  L
Sbjct: 61  RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL 120

Query: 93  TWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITK 152
            W+   +  + S+R+PS+++W PDIVLYN AD E +    T   L   G + W  PAI K
Sbjct: 121 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK 180

Query: 153 SSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVK 212
           SSC +DVT+FPFD Q C + FGSWTY+  ++D+     + DL D+ E  EW +       
Sbjct: 181 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY 240

Query: 213 NVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLG 272
           N   Y CC+E YPDVT+  +++R   FY +NL+IPC+LIS L  L FYLP+  GEK++L 
Sbjct: 241 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC 300

Query: 273 VTILLAMTVFQLMVAEIMPASENV-PLIGKYYIATMALITASTALTIMVMNIHFCGAEAR 331
           +++LL++TVF L++ EI+P++  V PLIG+Y + TM  +T S  +T+ V+N+H       
Sbjct: 301 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH 360

Query: 332 PVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAARNKDLS 391
            +PHW R  +L  + R L +          H  R +  L+  Y  L ESN+ A   + + 
Sbjct: 361 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLK--LSPSYHWL-ESNVDAEEREVVV 417

Query: 392 RKKD---MNKRLKNDLGC--------QGKNPQEAESYCAQYKVL--------TRNIEYIA 432
            ++D       +   +G          G +  +AE+   + ++L           + YIA
Sbjct: 418 EEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIA 477

Query: 433 KCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTI 472
             L+   A +S   +WK VA VIDR F+W+F I+ F+ TI
Sbjct: 478 DHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTI 517


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  306 bits (785), Expect = 2e-83
 Identities = 167/453 (36%), Positives = 268/453 (59%), Gaps = 32/453 (7%)

Query: 29  KYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWH 88
           ++  +L   LF+DYS+ +RPVED  +V+ VT+ + L Q+ ++DE NQI+T  + ++Q W 
Sbjct: 22  EHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWV 81

Query: 89  DAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAP 148
           D  L W+ D Y G+  I IPS+ +WRPD+VLYN AD + +    T V+L+Y G ITW  P
Sbjct: 82  DYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPP 141

Query: 149 AITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGM 208
           AI KS C + VT+FPFD Q C++  G+WTY+G+ V I    D  DLS+F+E  EW +   
Sbjct: 142 AIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKES 201

Query: 209 PAVKNVISYGCCSE-PYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGE 267
              K+ ++Y CC + PY D+T+  +++R   ++IVN++IPC+L SFL  L FYLP  SGE
Sbjct: 202 RGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGE 261

Query: 268 KVSLGVTILLAMTVFQLMVAEIMPA-SENVPLIGKYYIATMALITASTALTIMVMNIHFC 326
           K++L +++LL++TVF L++ E++P+ S  VPLIGKY + TM  + AS  +T++V+N H  
Sbjct: 262 KMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHR 321

Query: 327 GAEARPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAAR 386
                 +P+W R V +  +  ++F   +         SRE+    K++++          
Sbjct: 322 SPSTHVMPNWVRKVFIDTIPNIMFFSTM------KRPSREKQD-KKIFTE---------- 364

Query: 387 NKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQY---KVLTRNIEYIAKCLKDHKATNS 443
           + D+S   D++       G  G  P    S   ++   K     I+YIA+ +K  + +N+
Sbjct: 365 DIDIS---DIS-------GKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNN 414

Query: 444 KGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIA 476
             +EWK VA V+D   + +F ++  + T+ + A
Sbjct: 415 AAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFA 447


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  295 bits (755), Expect = 6e-80
 Identities = 138/321 (42%), Positives = 204/321 (63%), Gaps = 1/321 (0%)

Query: 32  QKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAY 91
           ++L   LF  Y+   RPV +   V+ V   ++++Q+ D+DE+NQ++T  +W++Q WHD  
Sbjct: 38  ERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYK 97

Query: 92  LTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAIT 151
           L WD   Y+ + SIRIPS+L+WRPDIVLYN AD + +    T   L +DG + W  PAI 
Sbjct: 98  LRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIY 157

Query: 152 KSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAV 211
           KSSC +DVT+FPFD Q C + FGSWTY+  ++D+ N     D  DF E  EW +      
Sbjct: 158 KSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGT 217

Query: 212 KNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSL 271
            N   Y CC+E YPD+T+  +++R   FY +NL+IPC+LIS L  L FYLP+  GEK++L
Sbjct: 218 YNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITL 277

Query: 272 GVTILLAMTVFQLMVAEIMPASENV-PLIGKYYIATMALITASTALTIMVMNIHFCGAEA 330
            +++LL++TVF L++ EI+P++  V PLIG+Y + TM  +T S  +T+ V+N+H      
Sbjct: 278 CISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRT 337

Query: 331 RPVPHWARVVILKYMSRVLFV 351
             +P W R V L  + R+L +
Sbjct: 338 HTMPTWVRRVFLDIVPRLLLM 358



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 23/52 (44%), Positives = 30/52 (57%), Gaps = 3/52 (5%)

Query: 424 LTRNIE---YIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTI 472
           LTR +E   YIA  LK      S   +WK VA VIDR F+W+F I+  + T+
Sbjct: 564 LTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTV 615


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  293 bits (749), Expect = 3e-79
 Identities = 167/478 (34%), Positives = 268/478 (56%), Gaps = 57/478 (11%)

Query: 29  KYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQ--- 85
           ++  +L   LF+DYS+ +RPVED  +V+ VT+ + L Q+ ++DE NQI+T  + ++Q   
Sbjct: 22  EHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDM 81

Query: 86  ----------------------IWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKA 123
                                  W D  L W+ D Y G+  I IPS+ +WRPD+VLYN A
Sbjct: 82  VDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNA 141

Query: 124 DDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQV 183
           D + +    T V+L+Y G ITW  PAI KS C + VT+FPFD Q C++  G+WTY+G+ V
Sbjct: 142 DGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVV 201

Query: 184 DIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSE-PYPDVTFTLLLKRRSSFYIV 242
            I    D  DLS+F+E  EW +      K+ ++Y CC + PY D+T+  +++R   ++IV
Sbjct: 202 AINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIV 261

Query: 243 NLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPA-SENVPLIGK 301
           N++IPC+L SFL  L FYLP  SGEK++L +++LL++TVF L++ E++P+ S  VPLIGK
Sbjct: 262 NVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGK 321

Query: 302 YYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSP 361
           Y + TM  + AS  +T++V+N H        +P+W R V +  +  ++F   +       
Sbjct: 322 YMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTM------K 375

Query: 362 HHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQY 421
             SRE+    K++++          + D+S   D++       G  G  P    S   ++
Sbjct: 376 RPSREKQD-KKIFTE----------DIDIS---DIS-------GKPGPPPMGFHSPLIKH 414

Query: 422 ---KVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIA 476
              K     I+YIA+ +K  + +N+  +EWK VA V+D   + +F ++  + T+ + A
Sbjct: 415 PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFA 472


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  288 bits (736), Expect = 1e-77
 Identities = 153/448 (34%), Positives = 251/448 (56%), Gaps = 33/448 (7%)

Query: 34  LFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLT 93
           L   LF+ Y   +RPV  ++  + V   + +SQ+ D+DE+NQ++T  +W++Q W D  L 
Sbjct: 32  LLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHKLR 91

Query: 94  WDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKS 153
           W+ D Y G+ SI++PS+ +W PDIVL+  AD      + T V+++ +G + W  PA  KS
Sbjct: 92  WNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPPASYKS 151

Query: 154 SCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKN 213
           SC +DVT+FPFD Q C++ FGSWTY+G  VD+    ++ D  DF ++ EWE+     +K 
Sbjct: 152 SCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILNAKGMKG 211

Query: 214 VISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGV 273
               G  S  YP +T++ +L+R   FY + L+IPC+ +SFL  L FYLP+  GEK+SL  
Sbjct: 212 NRRDGVYS--YPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLST 269

Query: 274 TILLAMTVFQLMVAEIMPASENV-PLIGKYYIATMALITASTALTIMVMNIHFCGAEA-R 331
           ++L+++TVF L++ EI+P+S  V PLIG+Y +  M  +T S  +T+ V+N+H   +    
Sbjct: 270 SVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYH 329

Query: 332 PVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAARNKDLS 391
           P+  W + + L+ + ++L        C+       +DH+ +  S   E +    + K L 
Sbjct: 330 PMAPWVKRLFLQKLPKLL--------CM-------KDHVDRYSSPEKEESQPVVKGKVLE 374

Query: 392 RKKDMNKRLKNDLGCQGKNPQEAESYCAQY-KVLTRNIEYIAKCLKDHKATNSKGSEWKK 450
           +KK              K   + E     + +    +I YI++ +K     +    +WK 
Sbjct: 375 KKKQ-------------KQLSDGEKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWKF 421

Query: 451 VAKVIDRFFMWIFFIMVFVMTILIIARA 478
           VA+V+DR F+W+F I+    ++LI   A
Sbjct: 422 VAQVLDRIFLWLFLIVSVTGSVLIFTPA 449


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  286 bits (732), Expect = 3e-77
 Identities = 156/455 (34%), Positives = 245/455 (53%), Gaps = 48/455 (10%)

Query: 17  ASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQI 76
           A R  +  ++  K+   L  DLF+DY   +RPVE  +  + +   + +SQ+ D+DE+NQ+
Sbjct: 33  AQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQL 92

Query: 77  LTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVV 136
           +T  +W++Q W D  L W+ D Y G+  IR+PSD VW PDIVL++ AD    E  +T  V
Sbjct: 93  MTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRF-EGTSTKTV 151

Query: 137 LRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSD 196
           +RY+G +TW  PA  KSSC +DVT+FPFD Q C++ FGSWTY+G+QVDI       D  D
Sbjct: 152 IRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRD 211

Query: 197 FIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAP 256
           F ++ EWE+      K   +  CC  PY  VT++ ++KR   FY + L+IPC+ +SFL  
Sbjct: 212 FFDNGEWEIVSATGSKGNRTDSCCWYPY--VTYSFVIKRLPLFYTLFLIIPCIGLSFLTV 269

Query: 257 LSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENV-PLIGKYYIATMALITASTA 315
           L FYLP+  GEK+ L  ++L+++TVF L++ EI+P+S  V PLIG+Y + TM  +T S  
Sbjct: 270 LVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIM 329

Query: 316 LTIMVMNIHFCGAEA-RPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVY 374
           +T+  +NIH   +     +    R + L  + ++L        C+       R H+ + +
Sbjct: 330 VTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLL--------CM-------RSHVDRYF 374

Query: 375 SKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKC 434
           ++  E+                           G  P+ + +     +    +I YI + 
Sbjct: 375 TQKEETE-------------------------SGSGPKSSRN---TLEAALDSIRYITRH 406

Query: 435 LKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFV 469
           +           +WK +A+V+DR F+W F  +  V
Sbjct: 407 IMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIV 441


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  280 bits (715), Expect = 3e-75
 Identities = 152/459 (33%), Positives = 252/459 (54%), Gaps = 29/459 (6%)

Query: 32  QKLFNDLFED--YSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHD 89
           +KL +DL     Y+N +RP   + +++++ LQ++L+Q+  ++ER QI+T  +W++Q W D
Sbjct: 28  EKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTD 87

Query: 90  AYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPA 149
             LTW+  +Y+G++ +RIP+  +W PDIVLYN AD      V TN+++R +G + W  PA
Sbjct: 88  YRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPA 147

Query: 150 ITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMP 209
           I KS+C ++V YFPFD Q C L F SWTY+  ++D+     +  + DF    EW++  +P
Sbjct: 148 IYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALP 207

Query: 210 AVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKV 269
             + V         Y DVT+  ++KR+  FY +NL+IPCVL + LA L FYLP+  GEK+
Sbjct: 208 GRRTVNPQ---DPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKM 264

Query: 270 SLGVTILLAMTVFQLMVAEIM-PASENVPLIGKYYIATMALITASTALTIMVMNIHFCGA 328
           +L +++LLA+T F L++++I+ P S +VPLIGKY + TM L+T S   ++ V+N+H    
Sbjct: 265 TLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSP 324

Query: 329 EARPVPHWARVVILKYMSRVLFVYDVG-ESCLSPHHSRERDHLTKVYSKLPESNLKAARN 387
               +  W +   L  +   LF+   G +S  +      +  +TK     PE+    A +
Sbjct: 325 STHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTK-----PEA---TATS 376

Query: 388 KDLSRKKDMNKRLKNDLGCQGKNP--------------QEAESYCAQYKVLTRNIEYIAK 433
              S     +    N      K+P              + +  +    +     + +IA+
Sbjct: 377 TSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQ 436

Query: 434 CLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTI 472
            +K+     S   +WK VA V+DR F+W+F  +  + T+
Sbjct: 437 HMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTV 475


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  275 bits (704), Expect = 5e-74
 Identities = 148/441 (33%), Positives = 236/441 (53%), Gaps = 24/441 (5%)

Query: 42  YSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDG 101
           Y+  +RP  +  +++ V L ++L+Q+  + ER QI+T  +W+ Q W D  LTW  +++D 
Sbjct: 42  YNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDN 101

Query: 102 LDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTY 161
           +  +R+PS  +W PD+VLYN AD        +N V+ YDG I W  PAI KS+C ++V +
Sbjct: 102 MKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKH 161

Query: 162 FPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCS 221
           FPFD Q C + F SWTY+  ++D+    +   L DF    EW++  +P  +N        
Sbjct: 162 FPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRN---ENPDD 218

Query: 222 EPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTV 281
             Y D+T+  +++R+  FY +NL+IPCVLI+ LA L FYLP+  GEK++L +++LLA+TV
Sbjct: 219 STYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTV 278

Query: 282 FQLMVAEIM-PASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVV 340
           F L++++I+ P S +VPL+GKY + TM L+T S   ++ V+N+H        +  W +VV
Sbjct: 279 FLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVV 338

Query: 341 ILKYMSRVLFVYDVGESCLSP-----HHSRERDHLTKVYSKLPESNLKAARNKDLSRKKD 395
            L+ +  +LF+      C           RER+    ++        + A   D      
Sbjct: 339 FLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALF-------FREAPGADSCTCFV 391

Query: 396 MNKRLKNDLGCQGKNP-------QEAESYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEW 448
               ++   G  G  P       +  E      +     + +IA  ++      S   +W
Sbjct: 392 NRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDW 451

Query: 449 KKVAKVIDRFFMWIF-FIMVF 468
           K VA VIDR F+WIF F+ VF
Sbjct: 452 KYVAMVIDRLFLWIFVFVCVF 472


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  244 bits (622), Expect = 2e-64
 Identities = 145/463 (31%), Positives = 237/463 (51%), Gaps = 20/463 (4%)

Query: 32  QKLFNDLFED--YSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHD 89
           ++L   LF++  Y+  LRPV   ++ ++V L +TLS +  + E  + LT  +WI   W D
Sbjct: 26  ERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTD 85

Query: 90  AYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPA 149
             L W+ +++  +  +R+P D+VW P+IVL N  D       + NV++ + G + W  PA
Sbjct: 86  NRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPA 145

Query: 150 ITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSG------------DLSDF 197
           I +SSC + VTYFPFD Q C+L F S  Y   ++ +    D+             D   F
Sbjct: 146 IFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGF 205

Query: 198 IEDVEWEVHGMPAVKNVISYGCCSEP-YPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAP 256
            E+ EWE+   PA  NV        P   D+TF L+++R+  FYI+N+L+PCVLISF+  
Sbjct: 206 TENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVN 265

Query: 257 LSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPA-SENVPLIGKYYIATMALITASTA 315
           L FYLPA SGEK S+ +++LLA +VF L++++ +PA S  +PLIGK+ +  M L+T    
Sbjct: 266 LVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVV 325

Query: 316 LTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYS 375
           + ++V+NIHF       +    + + L+ +  +L +    E   SP     R       S
Sbjct: 326 ICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYIS 385

Query: 376 KLPESNLKAARN----KDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYI 431
           K  E  L  +R+    +  S +  + +RL         + Q  +    + K       +I
Sbjct: 386 KAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFI 445

Query: 432 AKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILI 474
              ++D    N +   W +VA+ +DR  +++   ++ V T  I
Sbjct: 446 VNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWI 488


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  234 bits (596), Expect = 2e-61
 Identities = 146/486 (30%), Positives = 250/486 (51%), Gaps = 37/486 (7%)

Query: 17  ASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQI 76
           A  +R +E A+G+  +KLF+     Y +++RP  +    + V++ + L+Q+  ++E+++ 
Sbjct: 18  APGVRGSE-AEGRLREKLFSG----YDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEE 72

Query: 77  LTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVV 136
           ++  +++   W D  L+WD  ++DG+DS+RI ++ VW PD+VL N  D      ++ +VV
Sbjct: 73  MSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVV 132

Query: 137 LRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDL-- 194
           +  DG + W  P I +SSC + VTYFPFD Q C + F S++Y+ ++V +   L       
Sbjct: 133 VSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGH 192

Query: 195 -------SDFIEDVEWEVHGMPAVKNVIS-----YGCCSEPYPDVTFTLLLKRRSSFYIV 242
                    FIE+ +WE+   P+   +I       G       +V F L+++R+  FY+V
Sbjct: 193 QEIHIHEGTFIENGQWEIIHKPS--RLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLV 250

Query: 243 NLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMP-ASENVPLIGK 301
           N++ PC+LI+ LA   FYLP  +GEK+ L +  LL +TVF L++A+ +P  S +VP+I K
Sbjct: 251 NVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIK 310

Query: 302 YYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVL---------FVY 352
           Y + TM L+T S  L+++V+N+H        +P W R + +  +   L          + 
Sbjct: 311 YLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPERDLM 370

Query: 353 DVGESCLSPHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQ 412
                C SP     R        K P   L    N+        + R   D       P 
Sbjct: 371 PEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFID------GPN 424

Query: 413 EAESYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTI 472
            A +   + + +  +I YIA+ L++ +  ++   +W+ VA V+DR F+W F I   V T+
Sbjct: 425 RAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTL 484

Query: 473 LIIARA 478
           +I   A
Sbjct: 485 VIFLDA 490


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  230 bits (587), Expect = 2e-60
 Identities = 136/458 (29%), Positives = 239/458 (52%), Gaps = 18/458 (3%)

Query: 33  KLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYL 92
           +L++ LF +Y    RPV + +  + ++L++TL+ +  ++E+ + LT  +WI   W D  L
Sbjct: 26  RLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRL 85

Query: 93  TWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITK 152
            + +D + G++++R+PS+LVW P+IVL N  D +     + NV++   G +TW  PAI +
Sbjct: 86  NYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYR 145

Query: 153 SSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSG---------DLSDFIEDVEW 203
           S C V+VTYFPFD Q C+L F S TYN  +V+   A+D+          D   + E+ EW
Sbjct: 146 SVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEW 205

Query: 204 EVHGMPAVKNVISYGCCSEP-YPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLP 262
            +   P V      G    P   DV ++L+++R+  FY++N+++PCVLIS L  L+++LP
Sbjct: 206 AIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLP 265

Query: 263 A-ASGEKVSLGVTILLAMTVFQLMVAEIMP-ASENVPLIGKYYIATMALITASTALTIMV 320
           A A G+K ++ + +LLA TVF  ++A+ +P  S +VPL+G++ I  M + T      ++V
Sbjct: 266 AQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIV 325

Query: 321 MNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPES 380
           +N+         +    R V+L+ + R+L      E+  +    R R     +  +  E 
Sbjct: 326 LNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPR-RASSVGLLLRAEEL 384

Query: 381 NLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKCLKDHKA 440
            LK  R++ +   +   +       CQ       E  C         + ++A+  +D +A
Sbjct: 385 ILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCC-----VDAVNFVAESTRDQEA 439

Query: 441 TNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARA 478
           T  + S+W ++   +D    W   ++  V + LI   A
Sbjct: 440 TGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGA 477


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  229 bits (584), Expect = 4e-60
 Identities = 137/386 (35%), Positives = 206/386 (53%), Gaps = 43/386 (11%)

Query: 123 ADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQ 182
           AD+      +TNV++   G   +  P I KSSC +DV +FPFD Q C L FGSW+Y G  
Sbjct: 28  ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS 87

Query: 183 VDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIV 242
           +D+   +   D+S +I + EW++ G+P  ++   Y CC EPYPDVTFT+ ++RR+ +Y +
Sbjct: 88  LDL--QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGL 145

Query: 243 NLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPA-SENVPLIGK 301
           NLLIPCVLIS LA L F LPA SGEK+SLG+T+LL++TVF L+VAEIMPA S++VPLI +
Sbjct: 146 NLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQ 205

Query: 302 YYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSP 361
           Y+ +TM ++  S  +T++V+  H    +   +P W RV++L + +  L +   GE  + P
Sbjct: 206 YFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRP 265

Query: 362 --HHSRERDHLTKVYSK---------------------------LPESNLKAARNKDLSR 392
              H + R  L  V                               P+S +   R   ++ 
Sbjct: 266 ACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGR---MAC 322

Query: 393 KKDMNKRLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEWKKVA 452
               ++ L       G  P E +   A+   +   + YIA   +    + +  SEWK  A
Sbjct: 323 SPTHDEHL-----LHGGQPPEGDPDLAK---ILEEVRYIANRFRCQDESEAVCSEWKFAA 374

Query: 453 KVIDRFFMWIFFIMVFVMTILIIARA 478
            V+DR  +  F +   + TI I+  A
Sbjct: 375 CVVDRLCLMAFSVFTIICTIGILMSA 400


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  217 bits (552), Expect = 2e-56
 Identities = 121/329 (36%), Positives = 185/329 (56%), Gaps = 11/329 (3%)

Query: 32  QKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAY 91
           ++L  DL ++Y   LRP E    V+NV+L++TL+ +  ++ER + LT  +WI   W D  
Sbjct: 27  ERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYR 86

Query: 92  LTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAIT 151
           L WD   Y+GL  +R+PS +VWRPDIVL N  D      +  NV++  DG I W  PAI 
Sbjct: 87  LRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIF 146

Query: 152 KSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSG--------DLSDFIEDVEW 203
           +S+C + VTYFPFD Q C+L F S TY+ N++D+  + + G        D   F E+ EW
Sbjct: 147 RSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAFTENGEW 206

Query: 204 EVHGMPAVKNVISYGCCSEP-YPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLP 262
            +   PA   +       E  +  V F LL++R+  FY++N++ PCVLIS +A L  +LP
Sbjct: 207 AIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLP 266

Query: 263 A-ASGEKVSLGVTILLAMTVFQLMVAEIMP-ASENVPLIGKYYIATMALITASTALTIMV 320
           A A G+K ++ + +LLA TVF  +VA+ +P  S+ VPLI KY    + +        ++V
Sbjct: 267 AKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVV 326

Query: 321 MNIHFCGAEARPVPHWARVVILKYMSRVL 349
           +N+         +    R V L+ + ++L
Sbjct: 327 LNVSLRSPHTHSMARGVRKVFLRLLPQLL 355


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  214 bits (544), Expect = 2e-55
 Identities = 131/449 (29%), Positives = 225/449 (50%), Gaps = 21/449 (4%)

Query: 33  KLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYL 92
           +L + L  +Y   +RPV D  K   V++ + +  I ++DE+NQ+LT Y+W RQ W D +L
Sbjct: 42  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 101

Query: 93  TWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITK 152
            W+ + +D +  + IP+D +W PDI L N+  D    P    V +R+ G +    P    
Sbjct: 102 QWNPEDFDNITKLSIPTDSIWVPDI-LINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVV 160

Query: 153 SSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDI----FNALDSGDLSDFIEDVEWEVHGM 208
           ++C +D+  FPFD Q C+LTF SW +    ++I           D S F+   EWE+ G+
Sbjct: 161 TACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGV 220

Query: 209 PAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEK 268
                  S    S  Y ++ F ++++RR  FY+V+LL+P + +  +  + FYLP  SGE+
Sbjct: 221 LPYFREFSME-SSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGER 279

Query: 269 VSLGVTILLAMTVFQLMVAEIMPASE-NVPLIGKYYIATMALITASTALTIMVMNIHFCG 327
           VS  +T+LL  +VF ++V++ +PA+    PLIG Y++  MAL+  S A TI ++ +    
Sbjct: 280 VSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQ 339

Query: 328 AEARPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAARN 387
              +PVP W R ++L+ ++ +L        CL    + +R   T   +K  + +      
Sbjct: 340 DLQQPVPAWLRHLVLERIAWLL--------CLREQSTSQRPPATSQATKTDDCSAMGNHC 391

Query: 388 KDLSRKKDMNKRLKNDLGCQGKNPQEAE-SYCAQYKVLTRNIEYIAKCLKDHKATNSKGS 446
             +   +D  K    D       P+EA  + C     L + +  I + L+          
Sbjct: 392 SHMGGPQDFEKS-PRDRCSPPPPPREASLAVCG----LLQELSSIRQFLEKRDEIREVAR 446

Query: 447 EWKKVAKVIDRFFMWIFFIMVFVMTILII 475
           +W +V  V+D+    I+ + V   +I ++
Sbjct: 447 DWLRVGSVLDKLLFHIYLLAVLAYSITLV 475


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  214 bits (544), Expect = 2e-55
 Identities = 131/449 (29%), Positives = 225/449 (50%), Gaps = 21/449 (4%)

Query: 33  KLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYL 92
           +L + L  +Y   +RPV D  K   V++ + +  I ++DE+NQ+LT Y+W RQ W D +L
Sbjct: 21  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 80

Query: 93  TWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITK 152
            W+ + +D +  + IP+D +W PDI L N+  D    P    V +R+ G +    P    
Sbjct: 81  QWNPEDFDNITKLSIPTDSIWVPDI-LINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVV 139

Query: 153 SSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDI----FNALDSGDLSDFIEDVEWEVHGM 208
           ++C +D+  FPFD Q C+LTF SW +    ++I           D S F+   EWE+ G+
Sbjct: 140 TACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGV 199

Query: 209 PAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEK 268
                  S    S  Y ++ F ++++RR  FY+V+LL+P + +  +  + FYLP  SGE+
Sbjct: 200 LPYFREFSME-SSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGER 258

Query: 269 VSLGVTILLAMTVFQLMVAEIMPASE-NVPLIGKYYIATMALITASTALTIMVMNIHFCG 327
           VS  +T+LL  +VF ++V++ +PA+    PLIG Y++  MAL+  S A TI ++ +    
Sbjct: 259 VSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQ 318

Query: 328 AEARPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAARN 387
              +PVP W R ++L+ ++ +L        CL    + +R   T   +K  + +      
Sbjct: 319 DLQQPVPAWLRHLVLERIAWLL--------CLREQSTSQRPPATSQATKTDDCSAMGNHC 370

Query: 388 KDLSRKKDMNKRLKNDLGCQGKNPQEAE-SYCAQYKVLTRNIEYIAKCLKDHKATNSKGS 446
             +   +D  K    D       P+EA  + C     L + +  I + L+          
Sbjct: 371 SHMGGPQDFEKS-PRDRCSPPPPPREASLAVCG----LLQELSSIRQFLEKRDEIREVAR 425

Query: 447 EWKKVAKVIDRFFMWIFFIMVFVMTILII 475
           +W +V  V+D+    I+ + V   +I ++
Sbjct: 426 DWLRVGSVLDKLLFHIYLLAVLAYSITLV 454


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  200 bits (508), Expect = 3e-51
 Identities = 132/481 (27%), Positives = 226/481 (46%), Gaps = 53/481 (11%)

Query: 33  KLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYL 92
           +L + L  +Y   +RPV D  K   V++ + +  I ++DE+NQ+LT Y+W RQ W D +L
Sbjct: 42  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 101

Query: 93  TWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITK 152
            W+ + +D +  + IP+D +W PDI L N+  D    P    V +R+ G +    P    
Sbjct: 102 QWNPEDFDNITKLSIPTDSIWVPDI-LINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVV 160

Query: 153 SSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDI----FNALDSGDLSDFIEDVEWEVHGM 208
           ++C +D+  FPFD Q C+LTF SW +    ++I           D S F+   EWE+ G+
Sbjct: 161 TACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGV 220

Query: 209 PAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEK 268
                  S    S  Y ++ F ++++RR  FY+V+LL+P + +  +  + FYLP  SGE+
Sbjct: 221 LPYFREFSME-SSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGER 279

Query: 269 VSLGVTILLAMTVFQLMVAEIMPASE-NVPLIGK-------------------------- 301
           VS  +T+LL  +VF ++V++ +PA+    PLIGK                          
Sbjct: 280 VSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASA 339

Query: 302 ------YYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVG 355
                 Y++  MAL+  S A TI ++ +       +PVP W R ++L+ ++ +L      
Sbjct: 340 LGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLL------ 393

Query: 356 ESCLSPHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAE 415
             CL    + +R   T   +K  + +        +   +D  K    D       P+EA 
Sbjct: 394 --CLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKS-PRDRCSPPPPPREAS 450

Query: 416 -SYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILI 474
            + C     L + +  I + L+          +W +V  V+D+    I+ + V   +I +
Sbjct: 451 LAVCG----LLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITL 506

Query: 475 I 475
           +
Sbjct: 507 V 507


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  177 bits (448), Expect = 2e-44
 Identities = 109/320 (34%), Positives = 168/320 (52%), Gaps = 41/320 (12%)

Query: 189 LDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPC 248
           +   D+S +I + EW++ G+P  ++   Y CC EPYPDVTFT+ ++RR+ +Y +NLLIPC
Sbjct: 1   MQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC 60

Query: 249 VLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPA-SENVPLIGKYYIATM 307
           VLIS LA L F LPA SGEK+SLG+T+LL++TVF L+VAEIMPA S++VPLI +Y+ +TM
Sbjct: 61  VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM 120

Query: 308 ALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSP--HHSR 365
            ++  S  +T++V+  H    +   +P W RV++L + +  L +   GE  + P   H +
Sbjct: 121 IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ 180

Query: 366 ERDHLTKVYSK---------------------------LPESNLKAARNKDLSRKKDMNK 398
            R  L  V                               P+S +   R   ++     ++
Sbjct: 181 RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGR---MACSPTHDE 237

Query: 399 RLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRF 458
            L       G  P E +   A+   +   + YIA   +    + +  SEWK  A V+DR 
Sbjct: 238 HL-----LHGGQPPEGDPDLAK---ILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRL 289

Query: 459 FMWIFFIMVFVMTILIIARA 478
            +  F +   + TI I+  A
Sbjct: 290 CLMAFSVFTIICTIGILMSA 309


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  169 bits (427), Expect = 7e-42
 Identities = 87/302 (28%), Positives = 161/302 (53%), Gaps = 10/302 (3%)

Query: 47  RPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIR 106
           RPV +      V +   +S I D++E+  +L+++LW+  +W + +++W+ ++ +G+  + 
Sbjct: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129

Query: 107 IPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDN 166
           + +  +W PDI +    D + + P      +  +G I +  P    S C +D+ YFPFD 
Sbjct: 130 MAAKNLWLPDIFIIELMDVDKT-PKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQ 188

Query: 167 QQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDV-----EWEVHGMPAVKNVISYGCCS 221
           Q C LTF S+ Y  + + +    +  +++D   ++     EWE+ G+      +S G   
Sbjct: 189 QNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRG--G 246

Query: 222 EPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTV 281
             Y  + F + ++RR S Y++NLL+P   +  +  LSFYLP  SG +V   +T+LL   V
Sbjct: 247 NLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNV 306

Query: 282 FQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMN-IHFCGAEARPVPHWARVV 340
           F LM+++++P S   PLIG Y+   ++L+  S   TI + + +H    +  P+P W   +
Sbjct: 307 FLLMMSDLLPTS-GTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSL 365

Query: 341 IL 342
           +L
Sbjct: 366 LL 367


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  162 bits (411), Expect = 5e-40
 Identities = 90/304 (29%), Positives = 157/304 (51%), Gaps = 10/304 (3%)

Query: 45  ALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDS 104
           A RP  +      V +  TLS I  +D + Q+LT++LW+  +W + ++ W+  +  G++ 
Sbjct: 53  AFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINK 112

Query: 105 IRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPF 164
           + + ++ +W PDI +    D + + P      +  +G I +D P    S C +D+ YFPF
Sbjct: 113 LTVLAENLWLPDIFIVESMDVDQT-PSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPF 171

Query: 165 DNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDV-----EWEVHGMPAVKNVISYGC 219
           D Q C  TF S+ Y  + + +    +  +++D    V     EWE+ G+      +S G 
Sbjct: 172 DQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMG- 230

Query: 220 CSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAM 279
            +  Y  + F + ++RR S YI+NLL+P   +  +  LSFYLPA S  +    +T+LL  
Sbjct: 231 -NNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGY 289

Query: 280 TVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMN-IHFCGAEARPVPHWAR 338
            VF LM+ +++PAS   PLI  Y+   ++L+  S   T+ +   +H    +  P+P W  
Sbjct: 290 NVFLLMMNDLLPAS-GTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLH 348

Query: 339 VVIL 342
            ++L
Sbjct: 349 SLLL 352


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  144 bits (364), Expect = 1e-34
 Identities = 83/293 (28%), Positives = 149/293 (50%), Gaps = 8/293 (2%)

Query: 34  LFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLT 93
           L   L + Y   +RPV +  K   V L + +  I D+D  NQIL   +W +++W+D +L+
Sbjct: 35  LSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLS 94

Query: 94  WDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKS 153
           W+   +D +  I +P   +W PDI++ N+  D    P    V +   G I    P    S
Sbjct: 95  WNSSMFDEIREISLPLSAIWAPDIII-NEFVDIERYPDLPYVYVNSSGTIENYKPIQVVS 153

Query: 154 SCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSD----FIEDVEWEVHGMP 209
           +C ++   FPFD Q C+LTF S  +    VD+       D+      F+ D EWE+  + 
Sbjct: 154 ACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVS 213

Query: 210 AVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKV 269
           +  +++     +  +  + F ++++R    Y+V+LLIP + +  +   SFYLP     ++
Sbjct: 214 STYSILQ--SSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARI 271

Query: 270 SLGVTILLAMTVFQLMVAEIMPAS-ENVPLIGKYYIATMALITASTALTIMVM 321
               ++L+  TVF++ ++  +P S  + PLIG ++   MA +  S A +I+++
Sbjct: 272 VFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLV 324


>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
           precursor [Homo sapiens]
          Length = 474

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 68/292 (23%), Positives = 135/292 (46%), Gaps = 9/292 (3%)

Query: 24  ETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWI 83
           E ++  Y ++  + L + Y   LRP +     ++V ++I ++ I  + E N   T  ++ 
Sbjct: 30  EPSNMSYVKETVDRLLKGYDIRLRP-DFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYF 88

Query: 84  RQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYN--KADDESSEPVNTNVVLRYDG 141
           +Q W D  L++     +     R+ +D +W PD    N  K+        N  + L  DG
Sbjct: 89  QQSWKDKRLSYSGIPLNLTLDNRV-ADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDG 147

Query: 142 LITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLS--DFIE 199
            + +     T ++C++D+  +P D Q C L   S+ Y  + ++ +     G ++  + IE
Sbjct: 148 TVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIE 207

Query: 200 DVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSF 259
             ++ +     V   + +   +  YP ++ +  LKR   ++I+   +P  LI+ L+ +SF
Sbjct: 208 LPQFSIVDYKMVSKKVEF--TTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSF 265

Query: 260 YLP-AASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALI 310
           ++   AS  +V+LG+T +L MT     + E +P    V  I  Y +     +
Sbjct: 266 WINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFV 317


>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 2 [Homo sapiens]
          Length = 474

 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 74/322 (22%), Positives = 141/322 (43%), Gaps = 9/322 (2%)

Query: 9   SFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIK 68
           SF  I  A       + ++    ++  + L + Y   LRP      V  V + I ++ I 
Sbjct: 14  SFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVA-VGMNIDIASID 72

Query: 69  DMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYN--KADDE 126
            + E N   T  ++ +Q W D  L+++    +     R+ +D +W PD    N  K+   
Sbjct: 73  MVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRV-ADQLWVPDTYFLNDKKSFVH 131

Query: 127 SSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIF 186
                N  + L  DG + +     T ++C++D+  +P D Q C L   S+ Y  + ++ +
Sbjct: 132 GVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFY 191

Query: 187 NALDSGDLSDF--IEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNL 244
              D   ++    IE  ++ +     +   + +   S  YP ++ +  LKR   ++I+  
Sbjct: 192 WRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGS--YPRLSLSFKLKRNIGYFILQT 249

Query: 245 LIPCVLISFLAPLSFYLP-AASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYY 303
            +P +LI+ L+ +SF++   AS  +V+LG+T +L MT     + E +P    V  I  Y 
Sbjct: 250 YMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYL 309

Query: 304 IATMALITASTALTIMVMNIHF 325
           +     +  +     +V  I F
Sbjct: 310 MGCFVFVFMALLEYALVNYIFF 331


>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 1 [Homo sapiens]
          Length = 512

 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 74/322 (22%), Positives = 141/322 (43%), Gaps = 9/322 (2%)

Query: 9   SFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIK 68
           SF  I  A       + ++    ++  + L + Y   LRP      V  V + I ++ I 
Sbjct: 14  SFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVA-VGMNIDIASID 72

Query: 69  DMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYN--KADDE 126
            + E N   T  ++ +Q W D  L+++    +     R+ +D +W PD    N  K+   
Sbjct: 73  MVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRV-ADQLWVPDTYFLNDKKSFVH 131

Query: 127 SSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIF 186
                N  + L  DG + +     T ++C++D+  +P D Q C L   S+ Y  + ++ +
Sbjct: 132 GVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFY 191

Query: 187 NALDSGDLSDF--IEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNL 244
              D   ++    IE  ++ +     +   + +   S  YP ++ +  LKR   ++I+  
Sbjct: 192 WRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGS--YPRLSLSFKLKRNIGYFILQT 249

Query: 245 LIPCVLISFLAPLSFYLP-AASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYY 303
            +P +LI+ L+ +SF++   AS  +V+LG+T +L MT     + E +P    V  I  Y 
Sbjct: 250 YMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYL 309

Query: 304 IATMALITASTALTIMVMNIHF 325
           +     +  +     +V  I F
Sbjct: 310 MGCFVFVFMALLEYALVNYIFF 331


>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 62/233 (26%), Positives = 108/233 (46%), Gaps = 13/233 (5%)

Query: 56  LNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRP 115
           +NVT  I ++    + E        +++RQ W+D+ L +     D LD      D +W+P
Sbjct: 71  VNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKP 130

Query: 116 DIVLYNKADDESSEPVNTNVVLRY--DGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTF 173
           D+   N+      +    N +LR   +G + +        SC +D+  FP D Q C +  
Sbjct: 131 DLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQL 190

Query: 174 GSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLL- 232
            S+ Y  N + IF  L  G     ++  E        +K     G C++ Y    FT + 
Sbjct: 191 ESFGYTMNDL-IFEWLSDGP----VQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIE 245

Query: 233 ----LKRRSSFYIVNLLIPCVLISFLAPLSFYLPA-ASGEKVSLGVTILLAMT 280
               L+R+  +Y++ + IP +LI  L+ +SF++   A+  +V+LG+T +L MT
Sbjct: 246 VKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMT 298


>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 62/233 (26%), Positives = 108/233 (46%), Gaps = 13/233 (5%)

Query: 56  LNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRP 115
           +NVT  I ++    + E        +++RQ W+D+ L +     D LD      D +W+P
Sbjct: 71  VNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKP 130

Query: 116 DIVLYNKADDESSEPVNTNVVLRY--DGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTF 173
           D+   N+      +    N +LR   +G + +        SC +D+  FP D Q C +  
Sbjct: 131 DLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQL 190

Query: 174 GSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLL- 232
            S+ Y  N + IF  L  G     ++  E        +K     G C++ Y    FT + 
Sbjct: 191 ESFGYTMNDL-IFEWLSDGP----VQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIE 245

Query: 233 ----LKRRSSFYIVNLLIPCVLISFLAPLSFYLPA-ASGEKVSLGVTILLAMT 280
               L+R+  +Y++ + IP +LI  L+ +SF++   A+  +V+LG+T +L MT
Sbjct: 246 VKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMT 298


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.136    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,108,457
Number of Sequences: 37866
Number of extensions: 722469
Number of successful extensions: 1826
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 1629
Number of HSP's gapped (non-prelim): 96
length of query: 479
length of database: 18,247,518
effective HSP length: 106
effective length of query: 373
effective length of database: 14,233,722
effective search space: 5309178306
effective search space used: 5309178306
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.