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Search of human proteins with 62988334
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62988334 cation channel, sperm associated 4 [Homo sapiens]
(472 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62988334 cation channel, sperm associated 4 [Homo sapiens] 939 0.0
gi|26051223 sperm-associated cation channel 2 isoform 2 [Homo sa... 98 1e-20
gi|16876443 sperm-associated cation channel 2 isoform 1 [Homo sa... 98 1e-20
gi|221316609 sperm-associated cation channel 1 [Homo sapiens] 92 1e-18
gi|29789451 cation channel, sperm associated 3 [Homo sapiens] 92 1e-18
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi... 91 2e-18
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo... 89 9e-18
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505280 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505278 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505270 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i... 89 1e-17
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor... 88 2e-17
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor... 88 2e-17
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor... 88 2e-17
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ... 86 6e-17
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo... 85 1e-16
gi|126362955 sodium channel, voltage-gated, type III, alpha isof... 84 2e-16
gi|126362947 sodium channel, voltage-gated, type III, alpha isof... 84 2e-16
gi|126362949 sodium channel, voltage-gated, type III, alpha isof... 84 2e-16
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s... 84 3e-16
>gi|62988334 cation channel, sperm associated 4 [Homo sapiens]
Length = 472
Score = 939 bits (2426), Expect = 0.0
Identities = 472/472 (100%), Positives = 472/472 (100%)
Query: 1 MRDNEKAWWQQWTSHTGLEGWGGTQEDRMGFGGAVAALRGRPSPLQSTIHESYGRPEEQV 60
MRDNEKAWWQQWTSHTGLEGWGGTQEDRMGFGGAVAALRGRPSPLQSTIHESYGRPEEQV
Sbjct: 1 MRDNEKAWWQQWTSHTGLEGWGGTQEDRMGFGGAVAALRGRPSPLQSTIHESYGRPEEQV 60
Query: 61 LINRQEITNKADAWDMQEFITHMYIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQK 120
LINRQEITNKADAWDMQEFITHMYIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQK
Sbjct: 61 LINRQEITNKADAWDMQEFITHMYIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQK 120
Query: 121 HYELFSTIDDIVLTILLCEVLLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPS 180
HYELFSTIDDIVLTILLCEVLLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPS
Sbjct: 121 HYELFSTIDDIVLTILLCEVLLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPS 180
Query: 181 INYTLRALRLVHVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFV 240
INYTLRALRLVHVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFV
Sbjct: 181 INYTLRALRLVHVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFV 240
Query: 241 PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGIN 300
PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGIN
Sbjct: 241 PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGIN 300
Query: 301 LFVIVVTTNLEQMMKAGEQGQQQRITFSETGAEEEEENDQLPLVHCVVARSEKSGLLQEP 360
LFVIVVTTNLEQMMKAGEQGQQQRITFSETGAEEEEENDQLPLVHCVVARSEKSGLLQEP
Sbjct: 301 LFVIVVTTNLEQMMKAGEQGQQQRITFSETGAEEEEENDQLPLVHCVVARSEKSGLLQEP 360
Query: 361 LAGGPLSNLSENTCDNFCLVLEAIQENLRQYKEIRDELNMIVEEVRAIRFNQEQESEVLN 420
LAGGPLSNLSENTCDNFCLVLEAIQENLRQYKEIRDELNMIVEEVRAIRFNQEQESEVLN
Sbjct: 361 LAGGPLSNLSENTCDNFCLVLEAIQENLRQYKEIRDELNMIVEEVRAIRFNQEQESEVLN 420
Query: 421 RRSSTSGSLETTSSKDIRQMSQQQDLLSALVSMEKVHDSSSQILLKKHKSSH 472
RRSSTSGSLETTSSKDIRQMSQQQDLLSALVSMEKVHDSSSQILLKKHKSSH
Sbjct: 421 RRSSTSGSLETTSSKDIRQMSQQQDLLSALVSMEKVHDSSSQILLKKHKSSH 472
>gi|26051223 sperm-associated cation channel 2 isoform 2 [Homo
sapiens]
Length = 530
Score = 98.2 bits (243), Expect = 1e-20
Identities = 64/248 (25%), Positives = 126/248 (50%), Gaps = 22/248 (8%)
Query: 88 LLRHPAFQLLLALLLVINAITIALRTN--SYLDQKHYELFSTIDD---IVLTILLCEVLL 142
+L P F+ + L+ +N I + + + K + L T++ +L I + E+LL
Sbjct: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
Query: 143 GWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLAR 202
WL+ F +FWK WN+ +F++ + LL + + + + L+ LR+ V +++ LA+
Sbjct: 164 KWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQ 223
Query: 203 ------IIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFV--PKH-------FQNI 247
II V+++++ M +++L+L F +F+V GV +F + P+ F ++
Sbjct: 224 FRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDL 283
Query: 248 QVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVT 307
+L T+FI T D W + D K I +IYF +++ +G+ I ++ V ++
Sbjct: 284 PNSLVTVFILFTLDHWYALLQD--VWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMV 341
Query: 308 TNLEQMMK 315
TN + + K
Sbjct: 342 TNFQNIRK 349
>gi|16876443 sperm-associated cation channel 2 isoform 1 [Homo
sapiens]
Length = 528
Score = 98.2 bits (243), Expect = 1e-20
Identities = 64/248 (25%), Positives = 126/248 (50%), Gaps = 22/248 (8%)
Query: 88 LLRHPAFQLLLALLLVINAITIALRTN--SYLDQKHYELFSTIDD---IVLTILLCEVLL 142
+L P F+ + L+ +N I + + + K + L T++ +L I + E+LL
Sbjct: 104 VLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILL 163
Query: 143 GWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLAR 202
WL+ F +FWK WN+ +F++ + LL + + + + L+ LR+ V +++ LA+
Sbjct: 164 KWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQ 223
Query: 203 ------IIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFV--PKH-------FQNI 247
II V+++++ M +++L+L F +F+V GV +F + P+ F ++
Sbjct: 224 FRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDL 283
Query: 248 QVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVT 307
+L T+FI T D W + D K I +IYF +++ +G+ I ++ V ++
Sbjct: 284 PNSLVTVFILFTLDHWYALLQD--VWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMV 341
Query: 308 TNLEQMMK 315
TN + + K
Sbjct: 342 TNFQNIRK 349
>gi|221316609 sperm-associated cation channel 1 [Homo sapiens]
Length = 780
Score = 92.0 bits (227), Expect = 1e-18
Identities = 71/269 (26%), Positives = 130/269 (48%), Gaps = 23/269 (8%)
Query: 74 WDMQEFITHMY---IKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDD 130
W+ F+ + I+ L + AF+ + ++ +N + + +T + ++ + F +D
Sbjct: 426 WEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDS 485
Query: 131 IVLTILLCEVLLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINY------- 183
I I + E LL + ++ D WN L+F I+ + +L F + + + +I +
Sbjct: 486 IFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRIL 545
Query: 184 ----TLRALRLVHVCMAVEPLARIIRV---ILQSVPDMANIMVLILFFMLVFSVFGVTLF 236
+LRALR + V + L + V + QS+P +A I++L+ + +FS LF
Sbjct: 546 KVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF 605
Query: 237 GAFVPKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAF 296
PK FQNI ++TLF +T D W IY D + + Y + I I+I I F
Sbjct: 606 RKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPI-----LVIYIIIQYF 660
Query: 297 IGINLFVIVVTTNLE-QMMKAGEQGQQQR 324
I +NL + V+ + + + K E+ +Q+R
Sbjct: 661 IFLNLVITVLVDSFQTALFKGLEKAKQER 689
>gi|29789451 cation channel, sperm associated 3 [Homo sapiens]
Length = 398
Score = 91.7 bits (226), Expect = 1e-18
Identities = 60/269 (22%), Positives = 138/269 (51%), Gaps = 16/269 (5%)
Query: 84 YIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLG 143
++K+++ F++++ + NA +AL T+ + + + L + ++I E+ +
Sbjct: 42 FVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMK 101
Query: 144 WLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYT-----LRALRLVHVCMAVE 198
+WK+G+N+L+ II+ ++ L + + ++ Y +++LR++ + +
Sbjct: 102 VYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQ 161
Query: 199 PLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGA---FVPKHFQNIQVALYTLF 255
+ +I + Q+V +A++++L+ M +F++ G LFG+ ++ N+ A +TLF
Sbjct: 162 GIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPDNGDHDNWGNLAAAFFTLF 221
Query: 256 ICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMK 315
T DGW D+ Q + RE+A+ + IFI + +FI +N+FV V+ + E ++
Sbjct: 222 SLATVDGWTDLQK--QLDNREFAL---SRAFTIIFILLASFIFLNMFVGVMIMHTEDSIR 276
Query: 316 AGEQG---QQQRITFSETGAEEEEENDQL 341
E+ +QQ + E + + +++
Sbjct: 277 KFERELMLEQQEMLMGEKQVILQRQQEEI 305
>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
Length = 1836
Score = 90.9 bits (224), Expect = 2e-18
Identities = 65/279 (23%), Positives = 127/279 (45%), Gaps = 51/279 (18%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHY--ELFSTIDDIVLTILLCEVLLGW 144
+++ H F+ + ++++++ +A + Y++Q+ + D + I + E+LL W
Sbjct: 1026 KIVEHNWFETFIVFMILLSSGALAFE-DIYIEQRRVIRTILEYADKVFTYIFIMEMLLKW 1084
Query: 145 LN-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSIN-----YTLRALRLVHVCMAVE 198
+ GF +++ + W L+F+IV + ++ N + + TLRALR + E
Sbjct: 1085 VAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFE 1144
Query: 199 PLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAF------------------ 239
+ ++ +L ++P + N++++ L F L+FS+ GV LF G F
Sbjct: 1145 GMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVN 1204
Query: 240 ------------------VPKHFQNIQVALYTLFICITQDGWVDIY-----SDFQTEKRE 276
V ++ N+ + +L T GW+DI S + E+ +
Sbjct: 1205 NKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQ 1264
Query: 277 YAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMK 315
Y + + +YF IFI G+F +NLF+ V+ N Q K
Sbjct: 1265 YEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1303
Score = 66.2 bits (160), Expect = 6e-11
Identities = 66/318 (20%), Positives = 138/318 (43%), Gaps = 53/318 (16%)
Query: 85 IKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLGW 144
+ L+ AF + + +L+ +N +T+ + T++ Q ++ I+ I + I E +L
Sbjct: 1346 VYDLVTKQAFDITIMILICLNMVTMMVETDNQ-SQLKVDILYNINMIFIIIFTGECVLKM 1404
Query: 145 LNGFWIFWKDGWNILNFIIVFI---------LLLRFFINEINIPSINYTLRALRLVHVCM 195
L ++ GWNI +F++V + L+ ++F++ P++ +R R+ V
Sbjct: 1405 LALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVS----PTLFRVIRLARIGRVLR 1460
Query: 196 AV---EPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPK--------HF 244
+ + + ++ ++ S+P + NI +L+ M ++S+FG++ F A+V K +F
Sbjct: 1461 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNF-AYVKKESGIDDMFNF 1519
Query: 245 QNIQVALYTLFICITQDGWVDIYSDF----------------QTEKREYAMEIGGAIYFT 288
+ ++ LF T GW + + + K + G +F
Sbjct: 1520 ETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFC 1579
Query: 289 IFITIGAFIGINLFVIVVTTNLEQMMKAGEQ--GQQQRITFSETGAEEEEENDQLPLVHC 346
+I I I +N+++ ++ N + + G+ F ET + + + Q
Sbjct: 1580 SYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQF----- 1634
Query: 347 VVARSEKSGL---LQEPL 361
+A S S LQEPL
Sbjct: 1635 -IAYSRLSDFVDTLQEPL 1651
Score = 61.2 bits (147), Expect = 2e-09
Identities = 55/262 (20%), Positives = 122/262 (46%), Gaps = 31/262 (11%)
Query: 85 IKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCEVLLG 143
I ++ P L + + +V+N + +A+ Y +H++ T+ ++V T I E++L
Sbjct: 571 IHLIVMDPFVDLGITICIVLNTLFMAME--HYPMTEHFDNVLTVGNLVFTGIFTAEMVLK 628
Query: 144 WLN-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLAR 202
+ + +++ GWNI + IIV + L+ + + S+ + R LR+ + + L
Sbjct: 629 LIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNM 688
Query: 203 IIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG-------------AFVPKHFQNIQV 249
+I++I SV + N+ +++ + +F+V G+ LFG +P+ +
Sbjct: 689 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFF 748
Query: 250 ALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG-AIYFTIFI---TIGAFIGINLFVIV 305
+ + I W++ D ME+ G A+ T+F+ IG + +NLF+ +
Sbjct: 749 HSFLIVFRILCGEWIETMWD--------CMEVAGQAMCLTVFLMVMVIGNLVVLNLFLAL 800
Query: 306 VTTNL--EQMMKAGEQGQQQRI 325
+ ++ + + + E G+ +
Sbjct: 801 LLSSFSADSLAASDEDGEMNNL 822
Score = 55.5 bits (132), Expect = 1e-07
Identities = 35/150 (23%), Positives = 75/150 (50%), Gaps = 3/150 (2%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLGWLN 146
++L H F + + + ++ N + + + + F+ I L+ + G+
Sbjct: 126 KVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGI--YTFESLIKILARGFCV 183
Query: 147 GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRV 206
+ F +D WN L+F ++ + L F++ NI ++ T R LR + + L I+
Sbjct: 184 DDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALR-TFRVLRALKTITVIPGLKTIVGA 242
Query: 207 ILQSVPDMANIMVLILFFMLVFSVFGVTLF 236
++QSV ++++M+L +F + VF++ G+ LF
Sbjct: 243 LIQSVKKLSDVMILTVFCLSVFALVGLQLF 272
Score = 32.3 bits (72), Expect = 0.96
Identities = 26/93 (27%), Positives = 40/93 (43%), Gaps = 16/93 (17%)
Query: 250 ALYTLFICITQDGWVDIYS-DFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTT 308
A LF +TQD W +++ + + Y I+F + I +G+F INL + VV
Sbjct: 395 AFLALFRLMTQDYWENLFQLTLRAAGKTYM------IFFVVIIFLGSFYLINLILAVV-- 446
Query: 309 NLEQMMKAGEQGQQQRITFSETGAEEEEENDQL 341
A +Q T +E +EEE L
Sbjct: 447 -------AMAYAEQNEATLAEDKEKEEEFQQML 472
>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
sapiens]
Length = 1791
Score = 89.0 bits (219), Expect = 9e-18
Identities = 70/268 (26%), Positives = 121/268 (45%), Gaps = 41/268 (15%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQ-KHYELFSTIDDIVLTILLCEVLLGWL 145
Q+++H F+ + ++++++ + +Q K EL + D I I + E++L W+
Sbjct: 1051 QIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWV 1110
Query: 146 N-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARII 204
GF ++ W L+FIIV I+ + IN + + S TLRALR + E + ++
Sbjct: 1111 AFGFGKYFTSAWCCLDFIIV-IVSVTTLINLMELKSFR-TLRALRPLRALSQFEGMKVVV 1168
Query: 205 RVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPK---------------------- 242
++ ++P + N++++ L F LVF + GV F K
Sbjct: 1169 NALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVINYTIITNKSQCES 1228
Query: 243 ----------HFQNIQVALYTLFICITQDGWVD-IYSDFQTEKREYAMEIG----GAIYF 287
+F N+ A L T GW+D IY+ + ++E E G IYF
Sbjct: 1229 GNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYF 1288
Query: 288 TIFITIGAFIGINLFVIVVTTNLEQMMK 315
+FI G+F +NLF+ V+ N Q K
Sbjct: 1289 VVFIIFGSFFTLNLFIGVIIDNFNQQQK 1316
Score = 60.1 bits (144), Expect = 4e-09
Identities = 59/295 (20%), Positives = 120/295 (40%), Gaps = 32/295 (10%)
Query: 94 FQLLLALLLVINAITIALRTNSYLDQKHYE-LFSTIDDIVLTILLCEVLLGWLNGFWIFW 152
F +++ L+++N I+ + SY K + + ++ + + I E L+ ++
Sbjct: 1368 FDIIIISLIILNMIS--MMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYF 1425
Query: 153 KDGWNILNFIIVFILLLRFFI----NEINIPSINYTLRALRLVHV------CMAVEPLAR 202
+GWN+ + ++V + ++ I N+ +IP R +RL + A +
Sbjct: 1426 TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRT 1485
Query: 203 IIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPK-------HFQNIQVALYTLF 255
++ ++ S+P + NI +L+ M ++++ G+ F P+ +F+ ++ LF
Sbjct: 1486 LLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLF 1545
Query: 256 ICITQDGWVDIYSDFQTEKREYAMEIGGA-------IYFTIFITIGAFIGINLFVIVVTT 308
T GW + S K YF +I I I +N+++ V+
Sbjct: 1546 QISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILE 1605
Query: 309 NLEQMMKAGEQ--GQQQRITFSETGAEEEEENDQLPLVHCVVARSEKSGLLQEPL 361
N + E G+ F E + + E Q A S+ + L EPL
Sbjct: 1606 NFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYS---ALSDFADALPEPL 1657
Score = 50.1 bits (118), Expect = 4e-06
Identities = 40/190 (21%), Positives = 94/190 (49%), Gaps = 10/190 (5%)
Query: 55 RPEEQVLINRQEITNKADAWDM--QEFITHMYIKQLLRHPAFQLLLALLLVINAITIALR 112
+ +E L + + +K W+ Q ++ ++ P +L + + ++IN + +A+
Sbjct: 538 KSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAME 597
Query: 113 TNSYLDQKHYELFSTIDDIVLT-ILLCEVLLGWLN-GFWIFWKDGWNILNFIIV---FIL 167
+ + +E I ++V T I + E+ L + + +++ GWNI + I+ F
Sbjct: 598 HHKM--EASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFAD 655
Query: 168 LLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLV 227
++ + + + P + + R LR+ + + L +I++I SV + ++ V+++ + +
Sbjct: 656 VMNCVLQKRSWPFLR-SFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFI 714
Query: 228 FSVFGVTLFG 237
FSV G+ LFG
Sbjct: 715 FSVVGMQLFG 724
Score = 36.2 bits (82), Expect = 0.066
Identities = 28/101 (27%), Positives = 47/101 (46%), Gaps = 8/101 (7%)
Query: 243 HFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
+F N + +F +TQD W +Y Y++ +F + I +G+F INL
Sbjct: 341 NFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSV-----FFFIVVIFLGSFYLINLT 395
Query: 303 VIVVTTNLEQMMK--AGEQGQQQRITFSETGAEEEEENDQL 341
+ VVT E+ K A E ++++ F E +EE + L
Sbjct: 396 LAVVTMAYEEQNKNVAAEIEAKEKM-FQEAQQLLKEEKEAL 435
>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
isoform 1 [Homo sapiens]
Length = 2377
Score = 88.6 bits (218), Expect = 1e-17
Identities = 68/284 (23%), Positives = 125/284 (44%), Gaps = 46/284 (16%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCE-----V 140
+++ H F ++ +++ +N ITIA+ +F T+ + + T + L E V
Sbjct: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330
Query: 141 LLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEIN--------IPSINYTLRALRLVH 192
LGW G + + WN+L+ ++V I ++ ++ ++ + + LR LR +
Sbjct: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390
Query: 193 VCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAFV----------- 240
V + L ++ ++ S+ + NI+V+ F ++F + GV LF G F
Sbjct: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450
Query: 241 ---------------PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG-- 283
+F N+ AL +LF+ ++DGWVDI D I
Sbjct: 1451 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1510
Query: 284 ---AIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQR 324
+YF F+ I AF +N+FV VV N + + E+ + +R
Sbjct: 1511 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1554
Score = 72.8 bits (177), Expect = 6e-13
Identities = 62/258 (24%), Positives = 116/258 (44%), Gaps = 43/258 (16%)
Query: 96 LLLALLLVINAITIALRTNSYLDQKHYELFSTIDD-------IVLTILLCEVLLGWLN-G 147
L + ++ +N +T+A+ +HY+ +D+ I I + E + + G
Sbjct: 1615 LFITGVIGLNVVTMAM--------EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1666
Query: 148 FWIFWKDGWNILNFIIVFILLLRFFINEINI-------PSINYTLRALRLVHVCMAVEP- 199
F F++D WN L+ IV + ++ + EI + P+I +R LR+ V ++
Sbjct: 1667 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1726
Query: 200 --LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAF----------VPKH--FQ 245
+ ++ ++Q++P + N+ +L + +F+ GV LFG + +H F+
Sbjct: 1727 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1786
Query: 246 NIQVALYTLFICITQDGW----VDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINL 301
N +A TLF T D W D D E Y I IYF F+ F+ +N+
Sbjct: 1787 NFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVIS-PIYFVSFVLTAQFVLVNV 1845
Query: 302 FVIVVTTNLEQMMKAGEQ 319
+ V+ +LE+ K ++
Sbjct: 1846 VIAVLMKHLEESNKEAKE 1863
Score = 64.7 bits (156), Expect = 2e-10
Identities = 51/227 (22%), Positives = 111/227 (48%), Gaps = 20/227 (8%)
Query: 98 LALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLC-EVLLGWL-NGFWIFWKDG 155
+ + +++N +++ + + ++ L I +IV T L E+LL L G + + K+
Sbjct: 749 IMIAILVNTLSMGIEYHEQPEELTNAL--EISNIVFTSLFALEMLLKLLVYGPFGYIKNP 806
Query: 156 WNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMA 215
+NI + +IV I + + S+ T R +R++ + + L R + V+++++ ++A
Sbjct: 807 YNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVA 866
Query: 216 NIMVLILFFMLVFSVFGVTLFGAFVP-----------KHFQNIQVALYTLFICITQDGWV 264
+L++ F+ +FS+ G+ LFG K+F ++ A+ T+F +TQ+ W
Sbjct: 867 TFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWN 926
Query: 265 DIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLE 311
+ + +A A+YF +T G ++ NL V ++ +
Sbjct: 927 KVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Score = 57.8 bits (138), Expect = 2e-08
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 16/169 (9%)
Query: 91 HPAFQLLLALLLVINAITIALRT---NSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNG 147
+P F+ + L++++N +T+ + + D + + DD + E+++ +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV-A 138
Query: 148 FWIFWK-----DGWNILNFIIVFILLLRFFINEINIP-SINYTLRALRLVHVCMAVEPLA 201
IF K D WN L+F IV +L + ++ N+ S T+R LR + V +
Sbjct: 139 LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMR 198
Query: 202 RIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG------AFVPKHF 244
++ ++L ++P + N+++L F +F + GV L+ F+P++F
Sbjct: 199 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENF 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 6/86 (6%)
Query: 243 HFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
+F NI A +F IT +GWVDI Y IYF + I +G+F INL
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF-----IYFILLIIVGSFFMINLC 390
Query: 303 VIVVTTNL-EQMMKAGEQGQQQRITF 327
++V+ T E + + ++QR+ F
Sbjct: 391 LVVIATQFSETKQRESQLMREQRVRF 416
>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
isoform 3 [Homo sapiens]
Length = 2343
Score = 88.6 bits (218), Expect = 1e-17
Identities = 68/284 (23%), Positives = 125/284 (44%), Gaps = 46/284 (16%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCE-----V 140
+++ H F ++ +++ +N ITIA+ +F T+ + + T + L E V
Sbjct: 1248 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1307
Query: 141 LLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEIN--------IPSINYTLRALRLVH 192
LGW G + + WN+L+ ++V I ++ ++ ++ + + LR LR +
Sbjct: 1308 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1367
Query: 193 VCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAFV----------- 240
V + L ++ ++ S+ + NI+V+ F ++F + GV LF G F
Sbjct: 1368 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1427
Query: 241 ---------------PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG-- 283
+F N+ AL +LF+ ++DGWVDI D I
Sbjct: 1428 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1487
Query: 284 ---AIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQR 324
+YF F+ I AF +N+FV VV N + + E+ + +R
Sbjct: 1488 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Score = 72.8 bits (177), Expect = 6e-13
Identities = 62/258 (24%), Positives = 116/258 (44%), Gaps = 43/258 (16%)
Query: 96 LLLALLLVINAITIALRTNSYLDQKHYELFSTIDD-------IVLTILLCEVLLGWLN-G 147
L + ++ +N +T+A+ +HY+ +D+ I I + E + + G
Sbjct: 1581 LFITGVIGLNVVTMAM--------EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1632
Query: 148 FWIFWKDGWNILNFIIVFILLLRFFINEINI-------PSINYTLRALRLVHVCMAVEP- 199
F F++D WN L+ IV + ++ + EI + P+I +R LR+ V ++
Sbjct: 1633 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1692
Query: 200 --LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAF----------VPKH--FQ 245
+ ++ ++Q++P + N+ +L + +F+ GV LFG + +H F+
Sbjct: 1693 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1752
Query: 246 NIQVALYTLFICITQDGW----VDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINL 301
N +A TLF T D W D D E Y I IYF F+ F+ +N+
Sbjct: 1753 NFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVIS-PIYFVSFVLTAQFVLVNV 1811
Query: 302 FVIVVTTNLEQMMKAGEQ 319
+ V+ +LE+ K ++
Sbjct: 1812 VIAVLMKHLEESNKEAKE 1829
Score = 64.7 bits (156), Expect = 2e-10
Identities = 51/227 (22%), Positives = 111/227 (48%), Gaps = 20/227 (8%)
Query: 98 LALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLC-EVLLGWL-NGFWIFWKDG 155
+ + +++N +++ + + ++ L I +IV T L E+LL L G + + K+
Sbjct: 749 IMIAILVNTLSMGIEYHEQPEELTNAL--EISNIVFTSLFALEMLLKLLVYGPFGYIKNP 806
Query: 156 WNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMA 215
+NI + +IV I + + S+ T R +R++ + + L R + V+++++ ++A
Sbjct: 807 YNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVA 866
Query: 216 NIMVLILFFMLVFSVFGVTLFGAFVP-----------KHFQNIQVALYTLFICITQDGWV 264
+L++ F+ +FS+ G+ LFG K+F ++ A+ T+F +TQ+ W
Sbjct: 867 TFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWN 926
Query: 265 DIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLE 311
+ + +A A+YF +T G ++ NL V ++ +
Sbjct: 927 KVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Score = 57.8 bits (138), Expect = 2e-08
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 16/169 (9%)
Query: 91 HPAFQLLLALLLVINAITIALRT---NSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNG 147
+P F+ + L++++N +T+ + + D + + DD + E+++ +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV-A 138
Query: 148 FWIFWK-----DGWNILNFIIVFILLLRFFINEINIP-SINYTLRALRLVHVCMAVEPLA 201
IF K D WN L+F IV +L + ++ N+ S T+R LR + V +
Sbjct: 139 LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMR 198
Query: 202 RIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG------AFVPKHF 244
++ ++L ++P + N+++L F +F + GV L+ F+P++F
Sbjct: 199 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENF 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 6/86 (6%)
Query: 243 HFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
+F NI A +F IT +GWVDI Y IYF + I +G+F INL
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF-----IYFILLIIVGSFFMINLC 390
Query: 303 VIVVTTNL-EQMMKAGEQGQQQRITF 327
++V+ T E + + ++QR+ F
Sbjct: 391 LVVIATQFSETKQRESQLMREQRVRF 416
>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
isoform 13 [Homo sapiens]
Length = 2243
Score = 88.6 bits (218), Expect = 1e-17
Identities = 68/284 (23%), Positives = 125/284 (44%), Gaps = 46/284 (16%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCE-----V 140
+++ H F ++ +++ +N ITIA+ +F T+ + + T + L E V
Sbjct: 1248 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1307
Query: 141 LLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEIN--------IPSINYTLRALRLVH 192
LGW G + + WN+L+ ++V I ++ ++ ++ + + LR LR +
Sbjct: 1308 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1367
Query: 193 VCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAFV----------- 240
V + L ++ ++ S+ + NI+V+ F ++F + GV LF G F
Sbjct: 1368 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1427
Query: 241 ---------------PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG-- 283
+F N+ AL +LF+ ++DGWVDI D I
Sbjct: 1428 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1487
Query: 284 ---AIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQR 324
+YF F+ I AF +N+FV VV N + + E+ + +R
Sbjct: 1488 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Score = 72.8 bits (177), Expect = 6e-13
Identities = 62/258 (24%), Positives = 116/258 (44%), Gaps = 43/258 (16%)
Query: 96 LLLALLLVINAITIALRTNSYLDQKHYELFSTIDD-------IVLTILLCEVLLGWLN-G 147
L + ++ +N +T+A+ +HY+ +D+ I I + E + + G
Sbjct: 1574 LFITGVIGLNVVTMAM--------EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1625
Query: 148 FWIFWKDGWNILNFIIVFILLLRFFINEINI-------PSINYTLRALRLVHVCMAVEP- 199
F F++D WN L+ IV + ++ + EI + P+I +R LR+ V ++
Sbjct: 1626 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1685
Query: 200 --LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAF----------VPKH--FQ 245
+ ++ ++Q++P + N+ +L + +F+ GV LFG + +H F+
Sbjct: 1686 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1745
Query: 246 NIQVALYTLFICITQDGW----VDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINL 301
N +A TLF T D W D D E Y I IYF F+ F+ +N+
Sbjct: 1746 NFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVIS-PIYFVSFVLTAQFVLVNV 1804
Query: 302 FVIVVTTNLEQMMKAGEQ 319
+ V+ +LE+ K ++
Sbjct: 1805 VIAVLMKHLEESNKEAKE 1822
Score = 64.7 bits (156), Expect = 2e-10
Identities = 51/227 (22%), Positives = 111/227 (48%), Gaps = 20/227 (8%)
Query: 98 LALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLC-EVLLGWL-NGFWIFWKDG 155
+ + +++N +++ + + ++ L I +IV T L E+LL L G + + K+
Sbjct: 749 IMIAILVNTLSMGIEYHEQPEELTNAL--EISNIVFTSLFALEMLLKLLVYGPFGYIKNP 806
Query: 156 WNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMA 215
+NI + +IV I + + S+ T R +R++ + + L R + V+++++ ++A
Sbjct: 807 YNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVA 866
Query: 216 NIMVLILFFMLVFSVFGVTLFGAFVP-----------KHFQNIQVALYTLFICITQDGWV 264
+L++ F+ +FS+ G+ LFG K+F ++ A+ T+F +TQ+ W
Sbjct: 867 TFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWN 926
Query: 265 DIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLE 311
+ + +A A+YF +T G ++ NL V ++ +
Sbjct: 927 KVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Score = 57.8 bits (138), Expect = 2e-08
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 16/169 (9%)
Query: 91 HPAFQLLLALLLVINAITIALRT---NSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNG 147
+P F+ + L++++N +T+ + + D + + DD + E+++ +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV-A 138
Query: 148 FWIFWK-----DGWNILNFIIVFILLLRFFINEINIP-SINYTLRALRLVHVCMAVEPLA 201
IF K D WN L+F IV +L + ++ N+ S T+R LR + V +
Sbjct: 139 LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMR 198
Query: 202 RIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG------AFVPKHF 244
++ ++L ++P + N+++L F +F + GV L+ F+P++F
Sbjct: 199 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENF 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 6/86 (6%)
Query: 243 HFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
+F NI A +F IT +GWVDI Y IYF + I +G+F INL
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF-----IYFILLIIVGSFFMINLC 390
Query: 303 VIVVTTNL-EQMMKAGEQGQQQRITF 327
++V+ T E + + ++QR+ F
Sbjct: 391 LVVIATQFSETKQRESQLMREQRVRF 416
>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
isoform 12 [Homo sapiens]
Length = 2250
Score = 88.6 bits (218), Expect = 1e-17
Identities = 68/284 (23%), Positives = 125/284 (44%), Gaps = 46/284 (16%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCE-----V 140
+++ H F ++ +++ +N ITIA+ +F T+ + + T + L E V
Sbjct: 1248 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1307
Query: 141 LLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEIN--------IPSINYTLRALRLVH 192
LGW G + + WN+L+ ++V I ++ ++ ++ + + LR LR +
Sbjct: 1308 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1367
Query: 193 VCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAFV----------- 240
V + L ++ ++ S+ + NI+V+ F ++F + GV LF G F
Sbjct: 1368 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1427
Query: 241 ---------------PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG-- 283
+F N+ AL +LF+ ++DGWVDI D I
Sbjct: 1428 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1487
Query: 284 ---AIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQR 324
+YF F+ I AF +N+FV VV N + + E+ + +R
Sbjct: 1488 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Score = 72.8 bits (177), Expect = 6e-13
Identities = 62/258 (24%), Positives = 116/258 (44%), Gaps = 43/258 (16%)
Query: 96 LLLALLLVINAITIALRTNSYLDQKHYELFSTIDD-------IVLTILLCEVLLGWLN-G 147
L + ++ +N +T+A+ +HY+ +D+ I I + E + + G
Sbjct: 1581 LFITGVIGLNVVTMAM--------EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1632
Query: 148 FWIFWKDGWNILNFIIVFILLLRFFINEINI-------PSINYTLRALRLVHVCMAVEP- 199
F F++D WN L+ IV + ++ + EI + P+I +R LR+ V ++
Sbjct: 1633 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1692
Query: 200 --LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAF----------VPKH--FQ 245
+ ++ ++Q++P + N+ +L + +F+ GV LFG + +H F+
Sbjct: 1693 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1752
Query: 246 NIQVALYTLFICITQDGW----VDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINL 301
N +A TLF T D W D D E Y I IYF F+ F+ +N+
Sbjct: 1753 NFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVIS-PIYFVSFVLTAQFVLVNV 1811
Query: 302 FVIVVTTNLEQMMKAGEQ 319
+ V+ +LE+ K ++
Sbjct: 1812 VIAVLMKHLEESNKEAKE 1829
Score = 64.7 bits (156), Expect = 2e-10
Identities = 51/227 (22%), Positives = 111/227 (48%), Gaps = 20/227 (8%)
Query: 98 LALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLC-EVLLGWL-NGFWIFWKDG 155
+ + +++N +++ + + ++ L I +IV T L E+LL L G + + K+
Sbjct: 749 IMIAILVNTLSMGIEYHEQPEELTNAL--EISNIVFTSLFALEMLLKLLVYGPFGYIKNP 806
Query: 156 WNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMA 215
+NI + +IV I + + S+ T R +R++ + + L R + V+++++ ++A
Sbjct: 807 YNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVA 866
Query: 216 NIMVLILFFMLVFSVFGVTLFGAFVP-----------KHFQNIQVALYTLFICITQDGWV 264
+L++ F+ +FS+ G+ LFG K+F ++ A+ T+F +TQ+ W
Sbjct: 867 TFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWN 926
Query: 265 DIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLE 311
+ + +A A+YF +T G ++ NL V ++ +
Sbjct: 927 KVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Score = 57.8 bits (138), Expect = 2e-08
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 16/169 (9%)
Query: 91 HPAFQLLLALLLVINAITIALRT---NSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNG 147
+P F+ + L++++N +T+ + + D + + DD + E+++ +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV-A 138
Query: 148 FWIFWK-----DGWNILNFIIVFILLLRFFINEINIP-SINYTLRALRLVHVCMAVEPLA 201
IF K D WN L+F IV +L + ++ N+ S T+R LR + V +
Sbjct: 139 LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMR 198
Query: 202 RIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG------AFVPKHF 244
++ ++L ++P + N+++L F +F + GV L+ F+P++F
Sbjct: 199 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENF 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 6/86 (6%)
Query: 243 HFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
+F NI A +F IT +GWVDI Y IYF + I +G+F INL
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF-----IYFILLIIVGSFFMINLC 390
Query: 303 VIVVTTNL-EQMMKAGEQGQQQRITF 327
++V+ T E + + ++QR+ F
Sbjct: 391 LVVIATQFSETKQRESQLMREQRVRF 416
>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
isoform 10 [Homo sapiens]
Length = 2266
Score = 88.6 bits (218), Expect = 1e-17
Identities = 68/284 (23%), Positives = 125/284 (44%), Gaps = 46/284 (16%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCE-----V 140
+++ H F ++ +++ +N ITIA+ +F T+ + + T + L E V
Sbjct: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330
Query: 141 LLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEIN--------IPSINYTLRALRLVH 192
LGW G + + WN+L+ ++V I ++ ++ ++ + + LR LR +
Sbjct: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390
Query: 193 VCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAFV----------- 240
V + L ++ ++ S+ + NI+V+ F ++F + GV LF G F
Sbjct: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450
Query: 241 ---------------PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG-- 283
+F N+ AL +LF+ ++DGWVDI D I
Sbjct: 1451 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1510
Query: 284 ---AIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQR 324
+YF F+ I AF +N+FV VV N + + E+ + +R
Sbjct: 1511 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1554
Score = 72.8 bits (177), Expect = 6e-13
Identities = 62/258 (24%), Positives = 116/258 (44%), Gaps = 43/258 (16%)
Query: 96 LLLALLLVINAITIALRTNSYLDQKHYELFSTIDD-------IVLTILLCEVLLGWLN-G 147
L + ++ +N +T+A+ +HY+ +D+ I I + E + + G
Sbjct: 1597 LFITGVIGLNVVTMAM--------EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1648
Query: 148 FWIFWKDGWNILNFIIVFILLLRFFINEINI-------PSINYTLRALRLVHVCMAVEP- 199
F F++D WN L+ IV + ++ + EI + P+I +R LR+ V ++
Sbjct: 1649 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1708
Query: 200 --LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAF----------VPKH--FQ 245
+ ++ ++Q++P + N+ +L + +F+ GV LFG + +H F+
Sbjct: 1709 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1768
Query: 246 NIQVALYTLFICITQDGW----VDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINL 301
N +A TLF T D W D D E Y I IYF F+ F+ +N+
Sbjct: 1769 NFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVIS-PIYFVSFVLTAQFVLVNV 1827
Query: 302 FVIVVTTNLEQMMKAGEQ 319
+ V+ +LE+ K ++
Sbjct: 1828 VIAVLMKHLEESNKEAKE 1845
Score = 64.7 bits (156), Expect = 2e-10
Identities = 51/227 (22%), Positives = 111/227 (48%), Gaps = 20/227 (8%)
Query: 98 LALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLC-EVLLGWL-NGFWIFWKDG 155
+ + +++N +++ + + ++ L I +IV T L E+LL L G + + K+
Sbjct: 749 IMIAILVNTLSMGIEYHEQPEELTNAL--EISNIVFTSLFALEMLLKLLVYGPFGYIKNP 806
Query: 156 WNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMA 215
+NI + +IV I + + S+ T R +R++ + + L R + V+++++ ++A
Sbjct: 807 YNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVA 866
Query: 216 NIMVLILFFMLVFSVFGVTLFGAFVP-----------KHFQNIQVALYTLFICITQDGWV 264
+L++ F+ +FS+ G+ LFG K+F ++ A+ T+F +TQ+ W
Sbjct: 867 TFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWN 926
Query: 265 DIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLE 311
+ + +A A+YF +T G ++ NL V ++ +
Sbjct: 927 KVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Score = 57.8 bits (138), Expect = 2e-08
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 16/169 (9%)
Query: 91 HPAFQLLLALLLVINAITIALRT---NSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNG 147
+P F+ + L++++N +T+ + + D + + DD + E+++ +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV-A 138
Query: 148 FWIFWK-----DGWNILNFIIVFILLLRFFINEINIP-SINYTLRALRLVHVCMAVEPLA 201
IF K D WN L+F IV +L + ++ N+ S T+R LR + V +
Sbjct: 139 LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMR 198
Query: 202 RIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG------AFVPKHF 244
++ ++L ++P + N+++L F +F + GV L+ F+P++F
Sbjct: 199 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENF 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 6/86 (6%)
Query: 243 HFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
+F NI A +F IT +GWVDI Y IYF + I +G+F INL
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF-----IYFILLIIVGSFFMINLC 390
Query: 303 VIVVTTNL-EQMMKAGEQGQQQRITF 327
++V+ T E + + ++QR+ F
Sbjct: 391 LVVIATQFSETKQRESQLMREQRVRF 416
>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
isoform 4 [Homo sapiens]
Length = 2332
Score = 88.6 bits (218), Expect = 1e-17
Identities = 68/284 (23%), Positives = 125/284 (44%), Gaps = 46/284 (16%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCE-----V 140
+++ H F ++ +++ +N ITIA+ +F T+ + + T + L E V
Sbjct: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330
Query: 141 LLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEIN--------IPSINYTLRALRLVH 192
LGW G + + WN+L+ ++V I ++ ++ ++ + + LR LR +
Sbjct: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390
Query: 193 VCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAFV----------- 240
V + L ++ ++ S+ + NI+V+ F ++F + GV LF G F
Sbjct: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450
Query: 241 ---------------PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG-- 283
+F N+ AL +LF+ ++DGWVDI D I
Sbjct: 1451 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1510
Query: 284 ---AIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQR 324
+YF F+ I AF +N+FV VV N + + E+ + +R
Sbjct: 1511 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1554
Score = 72.8 bits (177), Expect = 6e-13
Identities = 62/258 (24%), Positives = 116/258 (44%), Gaps = 43/258 (16%)
Query: 96 LLLALLLVINAITIALRTNSYLDQKHYELFSTIDD-------IVLTILLCEVLLGWLN-G 147
L + ++ +N +T+A+ +HY+ +D+ I I + E + + G
Sbjct: 1615 LFITGVIGLNVVTMAM--------EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1666
Query: 148 FWIFWKDGWNILNFIIVFILLLRFFINEINI-------PSINYTLRALRLVHVCMAVEP- 199
F F++D WN L+ IV + ++ + EI + P+I +R LR+ V ++
Sbjct: 1667 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1726
Query: 200 --LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAF----------VPKH--FQ 245
+ ++ ++Q++P + N+ +L + +F+ GV LFG + +H F+
Sbjct: 1727 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1786
Query: 246 NIQVALYTLFICITQDGW----VDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINL 301
N +A TLF T D W D D E Y I IYF F+ F+ +N+
Sbjct: 1787 NFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVIS-PIYFVSFVLTAQFVLVNV 1845
Query: 302 FVIVVTTNLEQMMKAGEQ 319
+ V+ +LE+ K ++
Sbjct: 1846 VIAVLMKHLEESNKEAKE 1863
Score = 64.7 bits (156), Expect = 2e-10
Identities = 51/227 (22%), Positives = 111/227 (48%), Gaps = 20/227 (8%)
Query: 98 LALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLC-EVLLGWL-NGFWIFWKDG 155
+ + +++N +++ + + ++ L I +IV T L E+LL L G + + K+
Sbjct: 749 IMIAILVNTLSMGIEYHEQPEELTNAL--EISNIVFTSLFALEMLLKLLVYGPFGYIKNP 806
Query: 156 WNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMA 215
+NI + +IV I + + S+ T R +R++ + + L R + V+++++ ++A
Sbjct: 807 YNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVA 866
Query: 216 NIMVLILFFMLVFSVFGVTLFGAFVP-----------KHFQNIQVALYTLFICITQDGWV 264
+L++ F+ +FS+ G+ LFG K+F ++ A+ T+F +TQ+ W
Sbjct: 867 TFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWN 926
Query: 265 DIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLE 311
+ + +A A+YF +T G ++ NL V ++ +
Sbjct: 927 KVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Score = 57.8 bits (138), Expect = 2e-08
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 16/169 (9%)
Query: 91 HPAFQLLLALLLVINAITIALRT---NSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNG 147
+P F+ + L++++N +T+ + + D + + DD + E+++ +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV-A 138
Query: 148 FWIFWK-----DGWNILNFIIVFILLLRFFINEINIP-SINYTLRALRLVHVCMAVEPLA 201
IF K D WN L+F IV +L + ++ N+ S T+R LR + V +
Sbjct: 139 LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMR 198
Query: 202 RIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG------AFVPKHF 244
++ ++L ++P + N+++L F +F + GV L+ F+P++F
Sbjct: 199 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENF 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 6/86 (6%)
Query: 243 HFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
+F NI A +F IT +GWVDI Y IYF + I +G+F INL
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF-----IYFILLIIVGSFFMINLC 390
Query: 303 VIVVTTNL-EQMMKAGEQGQQQRITF 327
++V+ T E + + ++QR+ F
Sbjct: 391 LVVIATQFSETKQRESQLMREQRVRF 416
>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
isoform 8 [Homo sapiens]
Length = 2284
Score = 88.6 bits (218), Expect = 1e-17
Identities = 68/284 (23%), Positives = 125/284 (44%), Gaps = 46/284 (16%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCE-----V 140
+++ H F ++ +++ +N ITIA+ +F T+ + + T + L E V
Sbjct: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330
Query: 141 LLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEIN--------IPSINYTLRALRLVH 192
LGW G + + WN+L+ ++V I ++ ++ ++ + + LR LR +
Sbjct: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390
Query: 193 VCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAFV----------- 240
V + L ++ ++ S+ + NI+V+ F ++F + GV LF G F
Sbjct: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450
Query: 241 ---------------PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG-- 283
+F N+ AL +LF+ ++DGWVDI D I
Sbjct: 1451 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1510
Query: 284 ---AIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQR 324
+YF F+ I AF +N+FV VV N + + E+ + +R
Sbjct: 1511 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1554
Score = 72.8 bits (177), Expect = 6e-13
Identities = 62/258 (24%), Positives = 116/258 (44%), Gaps = 43/258 (16%)
Query: 96 LLLALLLVINAITIALRTNSYLDQKHYELFSTIDD-------IVLTILLCEVLLGWLN-G 147
L + ++ +N +T+A+ +HY+ +D+ I I + E + + G
Sbjct: 1615 LFITGVIGLNVVTMAM--------EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1666
Query: 148 FWIFWKDGWNILNFIIVFILLLRFFINEINI-------PSINYTLRALRLVHVCMAVEP- 199
F F++D WN L+ IV + ++ + EI + P+I +R LR+ V ++
Sbjct: 1667 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1726
Query: 200 --LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAF----------VPKH--FQ 245
+ ++ ++Q++P + N+ +L + +F+ GV LFG + +H F+
Sbjct: 1727 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1786
Query: 246 NIQVALYTLFICITQDGW----VDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINL 301
N +A TLF T D W D D E Y I IYF F+ F+ +N+
Sbjct: 1787 NFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVIS-PIYFVSFVLTAQFVLVNV 1845
Query: 302 FVIVVTTNLEQMMKAGEQ 319
+ V+ +LE+ K ++
Sbjct: 1846 VIAVLMKHLEESNKEAKE 1863
Score = 64.7 bits (156), Expect = 2e-10
Identities = 51/227 (22%), Positives = 111/227 (48%), Gaps = 20/227 (8%)
Query: 98 LALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLC-EVLLGWL-NGFWIFWKDG 155
+ + +++N +++ + + ++ L I +IV T L E+LL L G + + K+
Sbjct: 749 IMIAILVNTLSMGIEYHEQPEELTNAL--EISNIVFTSLFALEMLLKLLVYGPFGYIKNP 806
Query: 156 WNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMA 215
+NI + +IV I + + S+ T R +R++ + + L R + V+++++ ++A
Sbjct: 807 YNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVA 866
Query: 216 NIMVLILFFMLVFSVFGVTLFGAFVP-----------KHFQNIQVALYTLFICITQDGWV 264
+L++ F+ +FS+ G+ LFG K+F ++ A+ T+F +TQ+ W
Sbjct: 867 TFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWN 926
Query: 265 DIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLE 311
+ + +A A+YF +T G ++ NL V ++ +
Sbjct: 927 KVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Score = 57.8 bits (138), Expect = 2e-08
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 16/169 (9%)
Query: 91 HPAFQLLLALLLVINAITIALRT---NSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNG 147
+P F+ + L++++N +T+ + + D + + DD + E+++ +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV-A 138
Query: 148 FWIFWK-----DGWNILNFIIVFILLLRFFINEINIP-SINYTLRALRLVHVCMAVEPLA 201
IF K D WN L+F IV +L + ++ N+ S T+R LR + V +
Sbjct: 139 LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMR 198
Query: 202 RIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG------AFVPKHF 244
++ ++L ++P + N+++L F +F + GV L+ F+P++F
Sbjct: 199 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENF 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 6/86 (6%)
Query: 243 HFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
+F NI A +F IT +GWVDI Y IYF + I +G+F INL
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF-----IYFILLIIVGSFFMINLC 390
Query: 303 VIVVTTNL-EQMMKAGEQGQQQRITF 327
++V+ T E + + ++QR+ F
Sbjct: 391 LVVIATQFSETKQRESQLMREQRVRF 416
>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
isoform 6 [Homo sapiens]
Length = 2306
Score = 88.6 bits (218), Expect = 1e-17
Identities = 68/284 (23%), Positives = 125/284 (44%), Gaps = 46/284 (16%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCE-----V 140
+++ H F ++ +++ +N ITIA+ +F T+ + + T + L E V
Sbjct: 1248 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1307
Query: 141 LLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEIN--------IPSINYTLRALRLVH 192
LGW G + + WN+L+ ++V I ++ ++ ++ + + LR LR +
Sbjct: 1308 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1367
Query: 193 VCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAFV----------- 240
V + L ++ ++ S+ + NI+V+ F ++F + GV LF G F
Sbjct: 1368 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1427
Query: 241 ---------------PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG-- 283
+F N+ AL +LF+ ++DGWVDI D I
Sbjct: 1428 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1487
Query: 284 ---AIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQR 324
+YF F+ I AF +N+FV VV N + + E+ + +R
Sbjct: 1488 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Score = 72.8 bits (177), Expect = 6e-13
Identities = 62/258 (24%), Positives = 116/258 (44%), Gaps = 43/258 (16%)
Query: 96 LLLALLLVINAITIALRTNSYLDQKHYELFSTIDD-------IVLTILLCEVLLGWLN-G 147
L + ++ +N +T+A+ +HY+ +D+ I I + E + + G
Sbjct: 1592 LFITGVIGLNVVTMAM--------EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1643
Query: 148 FWIFWKDGWNILNFIIVFILLLRFFINEINI-------PSINYTLRALRLVHVCMAVEP- 199
F F++D WN L+ IV + ++ + EI + P+I +R LR+ V ++
Sbjct: 1644 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1703
Query: 200 --LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAF----------VPKH--FQ 245
+ ++ ++Q++P + N+ +L + +F+ GV LFG + +H F+
Sbjct: 1704 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1763
Query: 246 NIQVALYTLFICITQDGW----VDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINL 301
N +A TLF T D W D D E Y I IYF F+ F+ +N+
Sbjct: 1764 NFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVIS-PIYFVSFVLTAQFVLVNV 1822
Query: 302 FVIVVTTNLEQMMKAGEQ 319
+ V+ +LE+ K ++
Sbjct: 1823 VIAVLMKHLEESNKEAKE 1840
Score = 64.7 bits (156), Expect = 2e-10
Identities = 51/227 (22%), Positives = 111/227 (48%), Gaps = 20/227 (8%)
Query: 98 LALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLC-EVLLGWL-NGFWIFWKDG 155
+ + +++N +++ + + ++ L I +IV T L E+LL L G + + K+
Sbjct: 749 IMIAILVNTLSMGIEYHEQPEELTNAL--EISNIVFTSLFALEMLLKLLVYGPFGYIKNP 806
Query: 156 WNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMA 215
+NI + +IV I + + S+ T R +R++ + + L R + V+++++ ++A
Sbjct: 807 YNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVA 866
Query: 216 NIMVLILFFMLVFSVFGVTLFGAFVP-----------KHFQNIQVALYTLFICITQDGWV 264
+L++ F+ +FS+ G+ LFG K+F ++ A+ T+F +TQ+ W
Sbjct: 867 TFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWN 926
Query: 265 DIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLE 311
+ + +A A+YF +T G ++ NL V ++ +
Sbjct: 927 KVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Score = 57.8 bits (138), Expect = 2e-08
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 16/169 (9%)
Query: 91 HPAFQLLLALLLVINAITIALRT---NSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNG 147
+P F+ + L++++N +T+ + + D + + DD + E+++ +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV-A 138
Query: 148 FWIFWK-----DGWNILNFIIVFILLLRFFINEINIP-SINYTLRALRLVHVCMAVEPLA 201
IF K D WN L+F IV +L + ++ N+ S T+R LR + V +
Sbjct: 139 LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMR 198
Query: 202 RIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG------AFVPKHF 244
++ ++L ++P + N+++L F +F + GV L+ F+P++F
Sbjct: 199 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENF 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 6/86 (6%)
Query: 243 HFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
+F NI A +F IT +GWVDI Y IYF + I +G+F INL
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF-----IYFILLIIVGSFFMINLC 390
Query: 303 VIVVTTNL-EQMMKAGEQGQQQRITF 327
++V+ T E + + ++QR+ F
Sbjct: 391 LVVIATQFSETKQRESQLMREQRVRF 416
>gi|38505278 voltage-dependent calcium channel alpha 1G subunit
isoform 11 [Homo sapiens]
Length = 2261
Score = 88.6 bits (218), Expect = 1e-17
Identities = 68/284 (23%), Positives = 125/284 (44%), Gaps = 46/284 (16%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCE-----V 140
+++ H F ++ +++ +N ITIA+ +F T+ + + T + L E V
Sbjct: 1248 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1307
Query: 141 LLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEIN--------IPSINYTLRALRLVH 192
LGW G + + WN+L+ ++V I ++ ++ ++ + + LR LR +
Sbjct: 1308 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1367
Query: 193 VCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAFV----------- 240
V + L ++ ++ S+ + NI+V+ F ++F + GV LF G F
Sbjct: 1368 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1427
Query: 241 ---------------PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG-- 283
+F N+ AL +LF+ ++DGWVDI D I
Sbjct: 1428 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1487
Query: 284 ---AIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQR 324
+YF F+ I AF +N+FV VV N + + E+ + +R
Sbjct: 1488 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Score = 72.8 bits (177), Expect = 6e-13
Identities = 62/258 (24%), Positives = 116/258 (44%), Gaps = 43/258 (16%)
Query: 96 LLLALLLVINAITIALRTNSYLDQKHYELFSTIDD-------IVLTILLCEVLLGWLN-G 147
L + ++ +N +T+A+ +HY+ +D+ I I + E + + G
Sbjct: 1592 LFITGVIGLNVVTMAM--------EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1643
Query: 148 FWIFWKDGWNILNFIIVFILLLRFFINEINI-------PSINYTLRALRLVHVCMAVEP- 199
F F++D WN L+ IV + ++ + EI + P+I +R LR+ V ++
Sbjct: 1644 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1703
Query: 200 --LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAF----------VPKH--FQ 245
+ ++ ++Q++P + N+ +L + +F+ GV LFG + +H F+
Sbjct: 1704 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1763
Query: 246 NIQVALYTLFICITQDGW----VDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINL 301
N +A TLF T D W D D E Y I IYF F+ F+ +N+
Sbjct: 1764 NFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVIS-PIYFVSFVLTAQFVLVNV 1822
Query: 302 FVIVVTTNLEQMMKAGEQ 319
+ V+ +LE+ K ++
Sbjct: 1823 VIAVLMKHLEESNKEAKE 1840
Score = 64.7 bits (156), Expect = 2e-10
Identities = 51/227 (22%), Positives = 111/227 (48%), Gaps = 20/227 (8%)
Query: 98 LALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLC-EVLLGWL-NGFWIFWKDG 155
+ + +++N +++ + + ++ L I +IV T L E+LL L G + + K+
Sbjct: 749 IMIAILVNTLSMGIEYHEQPEELTNAL--EISNIVFTSLFALEMLLKLLVYGPFGYIKNP 806
Query: 156 WNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMA 215
+NI + +IV I + + S+ T R +R++ + + L R + V+++++ ++A
Sbjct: 807 YNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVA 866
Query: 216 NIMVLILFFMLVFSVFGVTLFGAFVP-----------KHFQNIQVALYTLFICITQDGWV 264
+L++ F+ +FS+ G+ LFG K+F ++ A+ T+F +TQ+ W
Sbjct: 867 TFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWN 926
Query: 265 DIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLE 311
+ + +A A+YF +T G ++ NL V ++ +
Sbjct: 927 KVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Score = 57.8 bits (138), Expect = 2e-08
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 16/169 (9%)
Query: 91 HPAFQLLLALLLVINAITIALRT---NSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNG 147
+P F+ + L++++N +T+ + + D + + DD + E+++ +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV-A 138
Query: 148 FWIFWK-----DGWNILNFIIVFILLLRFFINEINIP-SINYTLRALRLVHVCMAVEPLA 201
IF K D WN L+F IV +L + ++ N+ S T+R LR + V +
Sbjct: 139 LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMR 198
Query: 202 RIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG------AFVPKHF 244
++ ++L ++P + N+++L F +F + GV L+ F+P++F
Sbjct: 199 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENF 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 6/86 (6%)
Query: 243 HFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
+F NI A +F IT +GWVDI Y IYF + I +G+F INL
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF-----IYFILLIIVGSFFMINLC 390
Query: 303 VIVVTTNL-EQMMKAGEQGQQQRITF 327
++V+ T E + + ++QR+ F
Sbjct: 391 LVVIATQFSETKQRESQLMREQRVRF 416
>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
isoform 5 [Homo sapiens]
Length = 2321
Score = 88.6 bits (218), Expect = 1e-17
Identities = 68/284 (23%), Positives = 125/284 (44%), Gaps = 46/284 (16%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCE-----V 140
+++ H F ++ +++ +N ITIA+ +F T+ + + T + L E V
Sbjct: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330
Query: 141 LLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEIN--------IPSINYTLRALRLVH 192
LGW G + + WN+L+ ++V I ++ ++ ++ + + LR LR +
Sbjct: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390
Query: 193 VCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAFV----------- 240
V + L ++ ++ S+ + NI+V+ F ++F + GV LF G F
Sbjct: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450
Query: 241 ---------------PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG-- 283
+F N+ AL +LF+ ++DGWVDI D I
Sbjct: 1451 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1510
Query: 284 ---AIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQR 324
+YF F+ I AF +N+FV VV N + + E+ + +R
Sbjct: 1511 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1554
Score = 72.8 bits (177), Expect = 6e-13
Identities = 62/258 (24%), Positives = 116/258 (44%), Gaps = 43/258 (16%)
Query: 96 LLLALLLVINAITIALRTNSYLDQKHYELFSTIDD-------IVLTILLCEVLLGWLN-G 147
L + ++ +N +T+A+ +HY+ +D+ I I + E + + G
Sbjct: 1604 LFITGVIGLNVVTMAM--------EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1655
Query: 148 FWIFWKDGWNILNFIIVFILLLRFFINEINI-------PSINYTLRALRLVHVCMAVEP- 199
F F++D WN L+ IV + ++ + EI + P+I +R LR+ V ++
Sbjct: 1656 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1715
Query: 200 --LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAF----------VPKH--FQ 245
+ ++ ++Q++P + N+ +L + +F+ GV LFG + +H F+
Sbjct: 1716 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1775
Query: 246 NIQVALYTLFICITQDGW----VDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINL 301
N +A TLF T D W D D E Y I IYF F+ F+ +N+
Sbjct: 1776 NFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVIS-PIYFVSFVLTAQFVLVNV 1834
Query: 302 FVIVVTTNLEQMMKAGEQ 319
+ V+ +LE+ K ++
Sbjct: 1835 VIAVLMKHLEESNKEAKE 1852
Score = 64.7 bits (156), Expect = 2e-10
Identities = 51/227 (22%), Positives = 111/227 (48%), Gaps = 20/227 (8%)
Query: 98 LALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLC-EVLLGWL-NGFWIFWKDG 155
+ + +++N +++ + + ++ L I +IV T L E+LL L G + + K+
Sbjct: 749 IMIAILVNTLSMGIEYHEQPEELTNAL--EISNIVFTSLFALEMLLKLLVYGPFGYIKNP 806
Query: 156 WNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMA 215
+NI + +IV I + + S+ T R +R++ + + L R + V+++++ ++A
Sbjct: 807 YNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVA 866
Query: 216 NIMVLILFFMLVFSVFGVTLFGAFVP-----------KHFQNIQVALYTLFICITQDGWV 264
+L++ F+ +FS+ G+ LFG K+F ++ A+ T+F +TQ+ W
Sbjct: 867 TFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWN 926
Query: 265 DIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLE 311
+ + +A A+YF +T G ++ NL V ++ +
Sbjct: 927 KVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Score = 57.8 bits (138), Expect = 2e-08
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 16/169 (9%)
Query: 91 HPAFQLLLALLLVINAITIALRT---NSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNG 147
+P F+ + L++++N +T+ + + D + + DD + E+++ +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV-A 138
Query: 148 FWIFWK-----DGWNILNFIIVFILLLRFFINEINIP-SINYTLRALRLVHVCMAVEPLA 201
IF K D WN L+F IV +L + ++ N+ S T+R LR + V +
Sbjct: 139 LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMR 198
Query: 202 RIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG------AFVPKHF 244
++ ++L ++P + N+++L F +F + GV L+ F+P++F
Sbjct: 199 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENF 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 6/86 (6%)
Query: 243 HFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
+F NI A +F IT +GWVDI Y IYF + I +G+F INL
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF-----IYFILLIIVGSFFMINLC 390
Query: 303 VIVVTTNL-EQMMKAGEQGQQQRITF 327
++V+ T E + + ++QR+ F
Sbjct: 391 LVVIATQFSETKQRESQLMREQRVRF 416
>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
isoform 7 [Homo sapiens]
Length = 2298
Score = 88.6 bits (218), Expect = 1e-17
Identities = 68/284 (23%), Positives = 125/284 (44%), Gaps = 46/284 (16%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCE-----V 140
+++ H F ++ +++ +N ITIA+ +F T+ + + T + L E V
Sbjct: 1248 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1307
Query: 141 LLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEIN--------IPSINYTLRALRLVH 192
LGW G + + WN+L+ ++V I ++ ++ ++ + + LR LR +
Sbjct: 1308 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1367
Query: 193 VCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAFV----------- 240
V + L ++ ++ S+ + NI+V+ F ++F + GV LF G F
Sbjct: 1368 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1427
Query: 241 ---------------PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG-- 283
+F N+ AL +LF+ ++DGWVDI D I
Sbjct: 1428 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1487
Query: 284 ---AIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQR 324
+YF F+ I AF +N+FV VV N + + E+ + +R
Sbjct: 1488 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Score = 72.8 bits (177), Expect = 6e-13
Identities = 62/258 (24%), Positives = 116/258 (44%), Gaps = 43/258 (16%)
Query: 96 LLLALLLVINAITIALRTNSYLDQKHYELFSTIDD-------IVLTILLCEVLLGWLN-G 147
L + ++ +N +T+A+ +HY+ +D+ I I + E + + G
Sbjct: 1581 LFITGVIGLNVVTMAM--------EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1632
Query: 148 FWIFWKDGWNILNFIIVFILLLRFFINEINI-------PSINYTLRALRLVHVCMAVEP- 199
F F++D WN L+ IV + ++ + EI + P+I +R LR+ V ++
Sbjct: 1633 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1692
Query: 200 --LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAF----------VPKH--FQ 245
+ ++ ++Q++P + N+ +L + +F+ GV LFG + +H F+
Sbjct: 1693 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1752
Query: 246 NIQVALYTLFICITQDGW----VDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINL 301
N +A TLF T D W D D E Y I IYF F+ F+ +N+
Sbjct: 1753 NFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVIS-PIYFVSFVLTAQFVLVNV 1811
Query: 302 FVIVVTTNLEQMMKAGEQ 319
+ V+ +LE+ K ++
Sbjct: 1812 VIAVLMKHLEESNKEAKE 1829
Score = 64.7 bits (156), Expect = 2e-10
Identities = 51/227 (22%), Positives = 111/227 (48%), Gaps = 20/227 (8%)
Query: 98 LALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLC-EVLLGWL-NGFWIFWKDG 155
+ + +++N +++ + + ++ L I +IV T L E+LL L G + + K+
Sbjct: 749 IMIAILVNTLSMGIEYHEQPEELTNAL--EISNIVFTSLFALEMLLKLLVYGPFGYIKNP 806
Query: 156 WNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMA 215
+NI + +IV I + + S+ T R +R++ + + L R + V+++++ ++A
Sbjct: 807 YNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVA 866
Query: 216 NIMVLILFFMLVFSVFGVTLFGAFVP-----------KHFQNIQVALYTLFICITQDGWV 264
+L++ F+ +FS+ G+ LFG K+F ++ A+ T+F +TQ+ W
Sbjct: 867 TFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWN 926
Query: 265 DIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLE 311
+ + +A A+YF +T G ++ NL V ++ +
Sbjct: 927 KVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Score = 57.8 bits (138), Expect = 2e-08
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 16/169 (9%)
Query: 91 HPAFQLLLALLLVINAITIALRT---NSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNG 147
+P F+ + L++++N +T+ + + D + + DD + E+++ +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV-A 138
Query: 148 FWIFWK-----DGWNILNFIIVFILLLRFFINEINIP-SINYTLRALRLVHVCMAVEPLA 201
IF K D WN L+F IV +L + ++ N+ S T+R LR + V +
Sbjct: 139 LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMR 198
Query: 202 RIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG------AFVPKHF 244
++ ++L ++P + N+++L F +F + GV L+ F+P++F
Sbjct: 199 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENF 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 6/86 (6%)
Query: 243 HFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
+F NI A +F IT +GWVDI Y IYF + I +G+F INL
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF-----IYFILLIIVGSFFMINLC 390
Query: 303 VIVVTTNL-EQMMKAGEQGQQQRITF 327
++V+ T E + + ++QR+ F
Sbjct: 391 LVVIATQFSETKQRESQLMREQRVRF 416
>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
isoform 9 [Homo sapiens]
Length = 2273
Score = 88.6 bits (218), Expect = 1e-17
Identities = 68/284 (23%), Positives = 125/284 (44%), Gaps = 46/284 (16%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCE-----V 140
+++ H F ++ +++ +N ITIA+ +F T+ + + T + L E V
Sbjct: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330
Query: 141 LLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEIN--------IPSINYTLRALRLVH 192
LGW G + + WN+L+ ++V I ++ ++ ++ + + LR LR +
Sbjct: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390
Query: 193 VCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAFV----------- 240
V + L ++ ++ S+ + NI+V+ F ++F + GV LF G F
Sbjct: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450
Query: 241 ---------------PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG-- 283
+F N+ AL +LF+ ++DGWVDI D I
Sbjct: 1451 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1510
Query: 284 ---AIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQR 324
+YF F+ I AF +N+FV VV N + + E+ + +R
Sbjct: 1511 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1554
Score = 72.8 bits (177), Expect = 6e-13
Identities = 62/258 (24%), Positives = 116/258 (44%), Gaps = 43/258 (16%)
Query: 96 LLLALLLVINAITIALRTNSYLDQKHYELFSTIDD-------IVLTILLCEVLLGWLN-G 147
L + ++ +N +T+A+ +HY+ +D+ I I + E + + G
Sbjct: 1604 LFITGVIGLNVVTMAM--------EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1655
Query: 148 FWIFWKDGWNILNFIIVFILLLRFFINEINI-------PSINYTLRALRLVHVCMAVEP- 199
F F++D WN L+ IV + ++ + EI + P+I +R LR+ V ++
Sbjct: 1656 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1715
Query: 200 --LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAF----------VPKH--FQ 245
+ ++ ++Q++P + N+ +L + +F+ GV LFG + +H F+
Sbjct: 1716 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1775
Query: 246 NIQVALYTLFICITQDGW----VDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINL 301
N +A TLF T D W D D E Y I IYF F+ F+ +N+
Sbjct: 1776 NFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVIS-PIYFVSFVLTAQFVLVNV 1834
Query: 302 FVIVVTTNLEQMMKAGEQ 319
+ V+ +LE+ K ++
Sbjct: 1835 VIAVLMKHLEESNKEAKE 1852
Score = 64.7 bits (156), Expect = 2e-10
Identities = 51/227 (22%), Positives = 111/227 (48%), Gaps = 20/227 (8%)
Query: 98 LALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLC-EVLLGWL-NGFWIFWKDG 155
+ + +++N +++ + + ++ L I +IV T L E+LL L G + + K+
Sbjct: 749 IMIAILVNTLSMGIEYHEQPEELTNAL--EISNIVFTSLFALEMLLKLLVYGPFGYIKNP 806
Query: 156 WNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMA 215
+NI + +IV I + + S+ T R +R++ + + L R + V+++++ ++A
Sbjct: 807 YNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVA 866
Query: 216 NIMVLILFFMLVFSVFGVTLFGAFVP-----------KHFQNIQVALYTLFICITQDGWV 264
+L++ F+ +FS+ G+ LFG K+F ++ A+ T+F +TQ+ W
Sbjct: 867 TFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWN 926
Query: 265 DIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLE 311
+ + +A A+YF +T G ++ NL V ++ +
Sbjct: 927 KVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Score = 57.8 bits (138), Expect = 2e-08
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 16/169 (9%)
Query: 91 HPAFQLLLALLLVINAITIALRT---NSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNG 147
+P F+ + L++++N +T+ + + D + + DD + E+++ +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV-A 138
Query: 148 FWIFWK-----DGWNILNFIIVFILLLRFFINEINIP-SINYTLRALRLVHVCMAVEPLA 201
IF K D WN L+F IV +L + ++ N+ S T+R LR + V +
Sbjct: 139 LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMR 198
Query: 202 RIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG------AFVPKHF 244
++ ++L ++P + N+++L F +F + GV L+ F+P++F
Sbjct: 199 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENF 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 6/86 (6%)
Query: 243 HFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
+F NI A +F IT +GWVDI Y IYF + I +G+F INL
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF-----IYFILLIIVGSFFMINLC 390
Query: 303 VIVVTTNL-EQMMKAGEQGQQQRITF 327
++V+ T E + + ++QR+ F
Sbjct: 391 LVVIATQFSETKQRESQLMREQRVRF 416
>gi|38505270 voltage-dependent calcium channel alpha 1G subunit
isoform 2 [Homo sapiens]
Length = 2354
Score = 88.6 bits (218), Expect = 1e-17
Identities = 68/284 (23%), Positives = 125/284 (44%), Gaps = 46/284 (16%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCE-----V 140
+++ H F ++ +++ +N ITIA+ +F T+ + + T + L E V
Sbjct: 1248 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1307
Query: 141 LLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEIN--------IPSINYTLRALRLVH 192
LGW G + + WN+L+ ++V I ++ ++ ++ + + LR LR +
Sbjct: 1308 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1367
Query: 193 VCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAFV----------- 240
V + L ++ ++ S+ + NI+V+ F ++F + GV LF G F
Sbjct: 1368 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1427
Query: 241 ---------------PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG-- 283
+F N+ AL +LF+ ++DGWVDI D I
Sbjct: 1428 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1487
Query: 284 ---AIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQR 324
+YF F+ I AF +N+FV VV N + + E+ + +R
Sbjct: 1488 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Score = 72.8 bits (177), Expect = 6e-13
Identities = 62/258 (24%), Positives = 116/258 (44%), Gaps = 43/258 (16%)
Query: 96 LLLALLLVINAITIALRTNSYLDQKHYELFSTIDD-------IVLTILLCEVLLGWLN-G 147
L + ++ +N +T+A+ +HY+ +D+ I I + E + + G
Sbjct: 1592 LFITGVIGLNVVTMAM--------EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1643
Query: 148 FWIFWKDGWNILNFIIVFILLLRFFINEINI-------PSINYTLRALRLVHVCMAVEP- 199
F F++D WN L+ IV + ++ + EI + P+I +R LR+ V ++
Sbjct: 1644 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1703
Query: 200 --LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAF----------VPKH--FQ 245
+ ++ ++Q++P + N+ +L + +F+ GV LFG + +H F+
Sbjct: 1704 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1763
Query: 246 NIQVALYTLFICITQDGW----VDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINL 301
N +A TLF T D W D D E Y I IYF F+ F+ +N+
Sbjct: 1764 NFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVIS-PIYFVSFVLTAQFVLVNV 1822
Query: 302 FVIVVTTNLEQMMKAGEQ 319
+ V+ +LE+ K ++
Sbjct: 1823 VIAVLMKHLEESNKEAKE 1840
Score = 64.7 bits (156), Expect = 2e-10
Identities = 51/227 (22%), Positives = 111/227 (48%), Gaps = 20/227 (8%)
Query: 98 LALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLC-EVLLGWL-NGFWIFWKDG 155
+ + +++N +++ + + ++ L I +IV T L E+LL L G + + K+
Sbjct: 749 IMIAILVNTLSMGIEYHEQPEELTNAL--EISNIVFTSLFALEMLLKLLVYGPFGYIKNP 806
Query: 156 WNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMA 215
+NI + +IV I + + S+ T R +R++ + + L R + V+++++ ++A
Sbjct: 807 YNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVA 866
Query: 216 NIMVLILFFMLVFSVFGVTLFGAFVP-----------KHFQNIQVALYTLFICITQDGWV 264
+L++ F+ +FS+ G+ LFG K+F ++ A+ T+F +TQ+ W
Sbjct: 867 TFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWN 926
Query: 265 DIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLE 311
+ + +A A+YF +T G ++ NL V ++ +
Sbjct: 927 KVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Score = 57.8 bits (138), Expect = 2e-08
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 16/169 (9%)
Query: 91 HPAFQLLLALLLVINAITIALRT---NSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNG 147
+P F+ + L++++N +T+ + + D + + DD + E+++ +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV-A 138
Query: 148 FWIFWK-----DGWNILNFIIVFILLLRFFINEINIP-SINYTLRALRLVHVCMAVEPLA 201
IF K D WN L+F IV +L + ++ N+ S T+R LR + V +
Sbjct: 139 LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMR 198
Query: 202 RIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG------AFVPKHF 244
++ ++L ++P + N+++L F +F + GV L+ F+P++F
Sbjct: 199 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENF 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 6/86 (6%)
Query: 243 HFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
+F NI A +F IT +GWVDI Y IYF + I +G+F INL
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF-----IYFILLIIVGSFFMINLC 390
Query: 303 VIVVTTNL-EQMMKAGEQGQQQRITF 327
++V+ T E + + ++QR+ F
Sbjct: 391 LVVIATQFSETKQRESQLMREQRVRF 416
>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
isoform 14 [Homo sapiens]
Length = 2171
Score = 88.6 bits (218), Expect = 1e-17
Identities = 68/284 (23%), Positives = 125/284 (44%), Gaps = 46/284 (16%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCE-----V 140
+++ H F ++ +++ +N ITIA+ +F T+ + + T + L E V
Sbjct: 1248 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1307
Query: 141 LLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEIN--------IPSINYTLRALRLVH 192
LGW G + + WN+L+ ++V I ++ ++ ++ + + LR LR +
Sbjct: 1308 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1367
Query: 193 VCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAFV----------- 240
V + L ++ ++ S+ + NI+V+ F ++F + GV LF G F
Sbjct: 1368 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1427
Query: 241 ---------------PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG-- 283
+F N+ AL +LF+ ++DGWVDI D I
Sbjct: 1428 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1487
Query: 284 ---AIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQR 324
+YF F+ I AF +N+FV VV N + + E+ + +R
Sbjct: 1488 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Score = 72.8 bits (177), Expect = 6e-13
Identities = 62/258 (24%), Positives = 116/258 (44%), Gaps = 43/258 (16%)
Query: 96 LLLALLLVINAITIALRTNSYLDQKHYELFSTIDD-------IVLTILLCEVLLGWLN-G 147
L + ++ +N +T+A+ +HY+ +D+ I I + E + + G
Sbjct: 1581 LFITGVIGLNVVTMAM--------EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1632
Query: 148 FWIFWKDGWNILNFIIVFILLLRFFINEINI-------PSINYTLRALRLVHVCMAVEP- 199
F F++D WN L+ IV + ++ + EI + P+I +R LR+ V ++
Sbjct: 1633 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1692
Query: 200 --LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAF----------VPKH--FQ 245
+ ++ ++Q++P + N+ +L + +F+ GV LFG + +H F+
Sbjct: 1693 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFR 1752
Query: 246 NIQVALYTLFICITQDGW----VDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINL 301
N +A TLF T D W D D E Y I IYF F+ F+ +N+
Sbjct: 1753 NFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVIS-PIYFVSFVLTAQFVLVNV 1811
Query: 302 FVIVVTTNLEQMMKAGEQ 319
+ V+ +LE+ K ++
Sbjct: 1812 VIAVLMKHLEESNKEAKE 1829
Score = 64.7 bits (156), Expect = 2e-10
Identities = 51/227 (22%), Positives = 111/227 (48%), Gaps = 20/227 (8%)
Query: 98 LALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLC-EVLLGWL-NGFWIFWKDG 155
+ + +++N +++ + + ++ L I +IV T L E+LL L G + + K+
Sbjct: 749 IMIAILVNTLSMGIEYHEQPEELTNAL--EISNIVFTSLFALEMLLKLLVYGPFGYIKNP 806
Query: 156 WNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMA 215
+NI + +IV I + + S+ T R +R++ + + L R + V+++++ ++A
Sbjct: 807 YNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVA 866
Query: 216 NIMVLILFFMLVFSVFGVTLFGAFVP-----------KHFQNIQVALYTLFICITQDGWV 264
+L++ F+ +FS+ G+ LFG K+F ++ A+ T+F +TQ+ W
Sbjct: 867 TFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWN 926
Query: 265 DIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLE 311
+ + +A A+YF +T G ++ NL V ++ +
Sbjct: 927 KVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Score = 57.8 bits (138), Expect = 2e-08
Identities = 39/169 (23%), Positives = 82/169 (48%), Gaps = 16/169 (9%)
Query: 91 HPAFQLLLALLLVINAITIALRT---NSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNG 147
+P F+ + L++++N +T+ + + D + + DD + E+++ +
Sbjct: 80 NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV-A 138
Query: 148 FWIFWK-----DGWNILNFIIVFILLLRFFINEINIP-SINYTLRALRLVHVCMAVEPLA 201
IF K D WN L+F IV +L + ++ N+ S T+R LR + V +
Sbjct: 139 LGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMR 198
Query: 202 RIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG------AFVPKHF 244
++ ++L ++P + N+++L F +F + GV L+ F+P++F
Sbjct: 199 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENF 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 6/86 (6%)
Query: 243 HFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
+F NI A +F IT +GWVDI Y IYF + I +G+F INL
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF-----IYFILLIIVGSFFMINLC 390
Query: 303 VIVVTTNL-EQMMKAGEQGQQQRITF 327
++V+ T E + + ++QR+ F
Sbjct: 391 LVVIATQFSETKQRESQLMREQRVRF 416
>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
[Homo sapiens]
Length = 2005
Score = 87.8 bits (216), Expect = 2e-17
Identities = 67/280 (23%), Positives = 125/280 (44%), Gaps = 52/280 (18%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHY--ELFSTIDDIVLTILLCEVLLGW 144
+++ H F+ + ++++++ +A + Y++Q+ + D + I + E+LL W
Sbjct: 1203 KIVEHNWFETFIVFMILLSSGALAFE-DIYIEQRKTIKTMLEYADKVFTYIFILEMLLKW 1261
Query: 145 LN-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINY-----TLRALRLVHVCMAVE 198
+ GF +++ + W L+F+IV + L+ N + + TLRALR + E
Sbjct: 1262 VAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFE 1321
Query: 199 PLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAF------------------ 239
+ ++ +L ++P + N++++ L F L+FS+ GV LF G F
Sbjct: 1322 GMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVN 1381
Query: 240 -------------------VPKHFQNIQVALYTLFICITQDGWVDI-YSDFQTEKRE--- 276
V +F N+ + +L T GW+DI Y+ + E
Sbjct: 1382 NYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQP 1441
Query: 277 -YAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMK 315
Y + +YF IFI G+F +NLF+ V+ N Q K
Sbjct: 1442 KYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1481
Score = 62.4 bits (150), Expect = 9e-10
Identities = 46/248 (18%), Positives = 115/248 (46%), Gaps = 34/248 (13%)
Query: 94 FQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNGFWIFWK 153
F + + +L+ +N +T+ + T+ Q+ + I+ + + + E +L ++ + ++
Sbjct: 1533 FDISIMILICLNMVTMMVETDDQ-SQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFT 1591
Query: 154 DGWNILNFIIVFILLLRFFINEIN-----IPSINYTLRALRLVHVCMAVEP---LARIIR 205
GWNI +F++V + ++ F+ E+ P++ +R R+ + ++ + ++
Sbjct: 1592 IGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1651
Query: 206 VILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPK--------HFQNIQVALYTLFIC 257
++ S+P + NI +L+ M ++++FG++ F A+V + +F+ ++ LF
Sbjct: 1652 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKREVGIDDMFNFETFGNSMICLFQI 1710
Query: 258 ITQDGWVDIYS--------DFQTEKREYAMEIG--------GAIYFTIFITIGAFIGINL 301
T GW + + D +K + G +F +I I + +N+
Sbjct: 1711 TTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNM 1770
Query: 302 FVIVVTTN 309
++ V+ N
Sbjct: 1771 YIAVILEN 1778
Score = 56.2 bits (134), Expect = 6e-08
Identities = 39/151 (25%), Positives = 78/151 (51%), Gaps = 5/151 (3%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLL-GWL 145
++L H F +L+ ++ N + + + +N K+ E T I L ++L G+
Sbjct: 124 KILVHSLFNMLIMCTILTNCVFMTM-SNPPDWTKNVEY--TFTGIYTFESLIKILARGFC 180
Query: 146 NGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIR 205
+ F +D WN L+F ++ + F+N N+ ++ T R LR + + L I+
Sbjct: 181 LEDFTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALR-TFRVLRALKTISVIPGLKTIVG 239
Query: 206 VILQSVPDMANIMVLILFFMLVFSVFGVTLF 236
++QSV ++++M+L +F + VF++ G+ LF
Sbjct: 240 ALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
Score = 52.4 bits (124), Expect = 9e-07
Identities = 34/155 (21%), Positives = 79/155 (50%), Gaps = 4/155 (2%)
Query: 85 IKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCEVLLG 143
+ ++ P L + + +V+N + +A+ +Q + ++ ++V T I E+ L
Sbjct: 752 VNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQ--FSSVLSVGNLVFTGIFTAEMFLK 809
Query: 144 WLN-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLAR 202
+ + ++++GWNI + IV + L+ + + S+ + R LR+ + + L
Sbjct: 810 IIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNM 869
Query: 203 IIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG 237
+I++I SV + N+ +++ + +F+V G+ LFG
Sbjct: 870 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 904
Score = 37.7 bits (86), Expect = 0.023
Identities = 49/208 (23%), Positives = 93/208 (44%), Gaps = 16/208 (7%)
Query: 244 FQNIQVALYTLFICITQDGWVDIYS-DFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
F A +LF +TQD W ++Y + + Y I+F + I +G+F INL
Sbjct: 367 FDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM------IFFVLVIFLGSFYLINLI 420
Query: 303 VIVVTTNLEQMMKAG-EQGQQQRITFSETGAEEEEENDQLPLVHCVVARSEKSGLLQEPL 361
+ VV E+ +A E+ +Q+ F + + +++ ++ A + S ++
Sbjct: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEE-----AQAAAAAASAESRDFS 475
Query: 362 AGGPLSNLSENTCDNFCLVLEAIQENLRQYKEIRDELNMIVEEVRAIRFNQEQESEVLNR 421
G + SE++ L ++ ++ L+ ++ + + EE + R ++ ESE R
Sbjct: 476 GAGGIGVFSESSSVASKLSSKS-EKELKNRRKKKKQKEQSGEEEKNDRV-RKSESEDSIR 533
Query: 422 RSSTSGSLE-TTSSKDIRQMSQQQDLLS 448
R SLE + + + R S Q LLS
Sbjct: 534 RKGFRFSLEGSRLTYEKRFSSPHQSLLS 561
>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 87.8 bits (216), Expect = 2e-17
Identities = 67/280 (23%), Positives = 125/280 (44%), Gaps = 52/280 (18%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHY--ELFSTIDDIVLTILLCEVLLGW 144
+++ H F+ + ++++++ +A + Y++Q+ + D + I + E+LL W
Sbjct: 1203 KIVEHNWFETFIVFMILLSSGALAFE-DIYIEQRKTIKTMLEYADKVFTYIFILEMLLKW 1261
Query: 145 LN-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINY-----TLRALRLVHVCMAVE 198
+ GF +++ + W L+F+IV + L+ N + + TLRALR + E
Sbjct: 1262 VAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFE 1321
Query: 199 PLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAF------------------ 239
+ ++ +L ++P + N++++ L F L+FS+ GV LF G F
Sbjct: 1322 GMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVN 1381
Query: 240 -------------------VPKHFQNIQVALYTLFICITQDGWVDI-YSDFQTEKRE--- 276
V +F N+ + +L T GW+DI Y+ + E
Sbjct: 1382 NYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQP 1441
Query: 277 -YAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMK 315
Y + +YF IFI G+F +NLF+ V+ N Q K
Sbjct: 1442 KYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1481
Score = 62.4 bits (150), Expect = 9e-10
Identities = 46/248 (18%), Positives = 115/248 (46%), Gaps = 34/248 (13%)
Query: 94 FQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNGFWIFWK 153
F + + +L+ +N +T+ + T+ Q+ + I+ + + + E +L ++ + ++
Sbjct: 1533 FDISIMILICLNMVTMMVETDDQ-SQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFT 1591
Query: 154 DGWNILNFIIVFILLLRFFINEIN-----IPSINYTLRALRLVHVCMAVEP---LARIIR 205
GWNI +F++V + ++ F+ E+ P++ +R R+ + ++ + ++
Sbjct: 1592 IGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1651
Query: 206 VILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPK--------HFQNIQVALYTLFIC 257
++ S+P + NI +L+ M ++++FG++ F A+V + +F+ ++ LF
Sbjct: 1652 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKREVGIDDMFNFETFGNSMICLFQI 1710
Query: 258 ITQDGWVDIYS--------DFQTEKREYAMEIG--------GAIYFTIFITIGAFIGINL 301
T GW + + D +K + G +F +I I + +N+
Sbjct: 1711 TTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNM 1770
Query: 302 FVIVVTTN 309
++ V+ N
Sbjct: 1771 YIAVILEN 1778
Score = 54.3 bits (129), Expect = 2e-07
Identities = 38/151 (25%), Positives = 78/151 (51%), Gaps = 5/151 (3%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLL-GWL 145
++L H F +L+ ++ N + + + +N K+ E T I L ++L G+
Sbjct: 124 KILVHSLFNMLIMCTILTNCVFMTM-SNPPDWTKNVEY--TFTGIYTFESLIKILARGFC 180
Query: 146 NGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIR 205
+ F +D WN L+F ++ + F++ N+ ++ T R LR + + L I+
Sbjct: 181 LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALR-TFRVLRALKTISVIPGLKTIVG 239
Query: 206 VILQSVPDMANIMVLILFFMLVFSVFGVTLF 236
++QSV ++++M+L +F + VF++ G+ LF
Sbjct: 240 ALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
Score = 52.4 bits (124), Expect = 9e-07
Identities = 34/155 (21%), Positives = 79/155 (50%), Gaps = 4/155 (2%)
Query: 85 IKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCEVLLG 143
+ ++ P L + + +V+N + +A+ +Q + ++ ++V T I E+ L
Sbjct: 752 VNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQ--FSSVLSVGNLVFTGIFTAEMFLK 809
Query: 144 WLN-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLAR 202
+ + ++++GWNI + IV + L+ + + S+ + R LR+ + + L
Sbjct: 810 IIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNM 869
Query: 203 IIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG 237
+I++I SV + N+ +++ + +F+V G+ LFG
Sbjct: 870 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 904
Score = 37.7 bits (86), Expect = 0.023
Identities = 49/208 (23%), Positives = 93/208 (44%), Gaps = 16/208 (7%)
Query: 244 FQNIQVALYTLFICITQDGWVDIYS-DFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
F A +LF +TQD W ++Y + + Y I+F + I +G+F INL
Sbjct: 367 FDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM------IFFVLVIFLGSFYLINLI 420
Query: 303 VIVVTTNLEQMMKAG-EQGQQQRITFSETGAEEEEENDQLPLVHCVVARSEKSGLLQEPL 361
+ VV E+ +A E+ +Q+ F + + +++ ++ A + S ++
Sbjct: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEE-----AQAAAAAASAESRDFS 475
Query: 362 AGGPLSNLSENTCDNFCLVLEAIQENLRQYKEIRDELNMIVEEVRAIRFNQEQESEVLNR 421
G + SE++ L ++ ++ L+ ++ + + EE + R ++ ESE R
Sbjct: 476 GAGGIGVFSESSSVASKLSSKS-EKELKNRRKKKKQKEQSGEEEKNDRV-RKSESEDSIR 533
Query: 422 RSSTSGSLE-TTSSKDIRQMSQQQDLLS 448
R SLE + + + R S Q LLS
Sbjct: 534 RKGFRFSLEGSRLTYEKRFSSPHQSLLS 561
>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 87.8 bits (216), Expect = 2e-17
Identities = 67/280 (23%), Positives = 125/280 (44%), Gaps = 52/280 (18%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHY--ELFSTIDDIVLTILLCEVLLGW 144
+++ H F+ + ++++++ +A + Y++Q+ + D + I + E+LL W
Sbjct: 1203 KIVEHNWFETFIVFMILLSSGALAFE-DIYIEQRKTIKTMLEYADKVFTYIFILEMLLKW 1261
Query: 145 LN-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINY-----TLRALRLVHVCMAVE 198
+ GF +++ + W L+F+IV + L+ N + + TLRALR + E
Sbjct: 1262 VAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFE 1321
Query: 199 PLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAF------------------ 239
+ ++ +L ++P + N++++ L F L+FS+ GV LF G F
Sbjct: 1322 GMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVN 1381
Query: 240 -------------------VPKHFQNIQVALYTLFICITQDGWVDI-YSDFQTEKRE--- 276
V +F N+ + +L T GW+DI Y+ + E
Sbjct: 1382 NYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQP 1441
Query: 277 -YAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMK 315
Y + +YF IFI G+F +NLF+ V+ N Q K
Sbjct: 1442 KYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1481
Score = 62.4 bits (150), Expect = 9e-10
Identities = 46/248 (18%), Positives = 115/248 (46%), Gaps = 34/248 (13%)
Query: 94 FQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNGFWIFWK 153
F + + +L+ +N +T+ + T+ Q+ + I+ + + + E +L ++ + ++
Sbjct: 1533 FDISIMILICLNMVTMMVETDDQ-SQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFT 1591
Query: 154 DGWNILNFIIVFILLLRFFINEIN-----IPSINYTLRALRLVHVCMAVEP---LARIIR 205
GWNI +F++V + ++ F+ E+ P++ +R R+ + ++ + ++
Sbjct: 1592 IGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1651
Query: 206 VILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPK--------HFQNIQVALYTLFIC 257
++ S+P + NI +L+ M ++++FG++ F A+V + +F+ ++ LF
Sbjct: 1652 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKREVGIDDMFNFETFGNSMICLFQI 1710
Query: 258 ITQDGWVDIYS--------DFQTEKREYAMEIG--------GAIYFTIFITIGAFIGINL 301
T GW + + D +K + G +F +I I + +N+
Sbjct: 1711 TTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNM 1770
Query: 302 FVIVVTTN 309
++ V+ N
Sbjct: 1771 YIAVILEN 1778
Score = 54.3 bits (129), Expect = 2e-07
Identities = 38/151 (25%), Positives = 78/151 (51%), Gaps = 5/151 (3%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLL-GWL 145
++L H F +L+ ++ N + + + +N K+ E T I L ++L G+
Sbjct: 124 KILVHSLFNMLIMCTILTNCVFMTM-SNPPDWTKNVEY--TFTGIYTFESLIKILARGFC 180
Query: 146 NGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIR 205
+ F +D WN L+F ++ + F++ N+ ++ T R LR + + L I+
Sbjct: 181 LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALR-TFRVLRALKTISVIPGLKTIVG 239
Query: 206 VILQSVPDMANIMVLILFFMLVFSVFGVTLF 236
++QSV ++++M+L +F + VF++ G+ LF
Sbjct: 240 ALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
Score = 52.4 bits (124), Expect = 9e-07
Identities = 34/155 (21%), Positives = 79/155 (50%), Gaps = 4/155 (2%)
Query: 85 IKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCEVLLG 143
+ ++ P L + + +V+N + +A+ +Q + ++ ++V T I E+ L
Sbjct: 752 VNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQ--FSSVLSVGNLVFTGIFTAEMFLK 809
Query: 144 WLN-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLAR 202
+ + ++++GWNI + IV + L+ + + S+ + R LR+ + + L
Sbjct: 810 IIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNM 869
Query: 203 IIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG 237
+I++I SV + N+ +++ + +F+V G+ LFG
Sbjct: 870 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 904
Score = 37.7 bits (86), Expect = 0.023
Identities = 49/208 (23%), Positives = 93/208 (44%), Gaps = 16/208 (7%)
Query: 244 FQNIQVALYTLFICITQDGWVDIYS-DFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
F A +LF +TQD W ++Y + + Y I+F + I +G+F INL
Sbjct: 367 FDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM------IFFVLVIFLGSFYLINLI 420
Query: 303 VIVVTTNLEQMMKAG-EQGQQQRITFSETGAEEEEENDQLPLVHCVVARSEKSGLLQEPL 361
+ VV E+ +A E+ +Q+ F + + +++ ++ A + S ++
Sbjct: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEE-----AQAAAAAASAESRDFS 475
Query: 362 AGGPLSNLSENTCDNFCLVLEAIQENLRQYKEIRDELNMIVEEVRAIRFNQEQESEVLNR 421
G + SE++ L ++ ++ L+ ++ + + EE + R ++ ESE R
Sbjct: 476 GAGGIGVFSESSSVASKLSSKS-EKELKNRRKKKKQKEQSGEEEKNDRV-RKSESEDSIR 533
Query: 422 RSSTSGSLE-TTSSKDIRQMSQQQDLLS 448
R SLE + + + R S Q LLS
Sbjct: 534 RKGFRFSLEGSRLTYEKRFSSPHQSLLS 561
>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
sapiens]
Length = 1998
Score = 86.3 bits (212), Expect = 6e-17
Identities = 67/280 (23%), Positives = 123/280 (43%), Gaps = 52/280 (18%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHY--ELFSTIDDIVLTILLCEVLLGW 144
+++ H F+ + ++++++ +A + Y+DQ+ + D + I + E+LL W
Sbjct: 1202 RIVEHNWFETFIVFMILLSSGALAFE-DIYIDQRKTIKTMLEYADKVFTYIFILEMLLKW 1260
Query: 145 LN-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINY-----TLRALRLVHVCMAVE 198
+ G+ ++ + W L+F+IV + L+ N + + TLRALR + E
Sbjct: 1261 VAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFE 1320
Query: 199 PLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAF------------------ 239
+ ++ +L ++P + N++++ L F L+FS+ GV LF G F
Sbjct: 1321 GMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVN 1380
Query: 240 -------------------VPKHFQNIQVALYTLFICITQDGWVDI-YSDFQTEKRE--- 276
V +F N+ +L T GW+DI Y+ + E
Sbjct: 1381 NHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQP 1440
Query: 277 -YAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMK 315
Y + +YF IFI G+F +NLF+ V+ N Q K
Sbjct: 1441 KYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1480
Score = 63.5 bits (153), Expect = 4e-10
Identities = 48/250 (19%), Positives = 115/250 (46%), Gaps = 38/250 (15%)
Query: 94 FQLLLALLLVINAITIALRTNSYLDQKHY--ELFSTIDDIVLTILLCEVLLGWLNGFWIF 151
F + + +L+ +N +T+ + T+ DQ Y + S I+ + + + E +L ++ +
Sbjct: 1532 FDISIMILICLNMVTMMVETD---DQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYY 1588
Query: 152 WKDGWNILNFIIVFILLLRFFINEIN-----IPSINYTLRALRLVHVCMAVEP---LARI 203
+ GWNI +F++V + ++ F+ E+ P++ +R R+ + ++ + +
Sbjct: 1589 FTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTL 1648
Query: 204 IRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPK--------HFQNIQVALYTLF 255
+ ++ S+P + NI +L+ M ++++FG++ F A+V + +F+ ++ LF
Sbjct: 1649 LFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKREVGIDDMFNFETFGNSMICLF 1707
Query: 256 ICITQDGWVDIYSDF----------------QTEKREYAMEIGGAIYFTIFITIGAFIGI 299
T GW + + + K + G +F +I I + +
Sbjct: 1708 QITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVV 1767
Query: 300 NLFVIVVTTN 309
N+++ V+ N
Sbjct: 1768 NMYIAVILEN 1777
Score = 60.5 bits (145), Expect = 3e-09
Identities = 54/258 (20%), Positives = 118/258 (45%), Gaps = 33/258 (12%)
Query: 74 WDMQEF---ITHMYIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDD 130
WD + + H+ + ++ P L + + +V+N + +A+ D H+ T+ +
Sbjct: 737 WDCSPYWLKVKHV-VNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTD--HFNNVLTVGN 793
Query: 131 IVLT-ILLCEVLLGWLN-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRAL 188
+V T I E+ L + + ++++GWNI + IV + L+ + + S+ + R L
Sbjct: 794 LVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLL 853
Query: 189 RLVHVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG----------- 237
R+ + + L +I++I SV + N+ +++ + +F+V G+ LFG
Sbjct: 854 RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIA 913
Query: 238 --AFVPKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG-AIYFTIF---I 291
+P+ N + + + W++ D ME+ G A+ T+F +
Sbjct: 914 SDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWD--------CMEVAGQAMCLTVFMMVM 965
Query: 292 TIGAFIGINLFVIVVTTN 309
IG + +NLF+ ++ ++
Sbjct: 966 VIGNLVVLNLFLALLLSS 983
Score = 54.7 bits (130), Expect = 2e-07
Identities = 34/150 (22%), Positives = 74/150 (49%), Gaps = 3/150 (2%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLGWLN 146
++L H F +L+ ++ N + + + + F+ I L+ + G+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGI--YTFESLIKIIARGFCL 180
Query: 147 GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRV 206
+ F +D WN L+F ++ + F++ N+ ++ T R LR + + L I+
Sbjct: 181 EDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALR-TFRVLRALKTISVIPGLKTIVGA 239
Query: 207 ILQSVPDMANIMVLILFFMLVFSVFGVTLF 236
++QSV ++++M+L +F + VF++ G+ LF
Sbjct: 240 LIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
Score = 45.8 bits (107), Expect = 8e-05
Identities = 56/208 (26%), Positives = 90/208 (43%), Gaps = 17/208 (8%)
Query: 244 FQNIQVALYTLFICITQDGWVDIYS-DFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
F A +LF +TQD W ++Y + + Y I+F + I +G+F INL
Sbjct: 365 FDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM------IFFVLVIFLGSFYLINLI 418
Query: 303 VIVVTTNLEQMMKAG-EQGQQQRITFSETGAEEEEENDQLPLVHCVVARSEKSGLLQEPL 361
+ VV E+ +A E+ +Q+ F + E+ ++ + SE S +EP
Sbjct: 419 LAVVAMAYEEQNQATLEEAEQKEAEFQQM-IEQLKKQQEAAQQAATATASEHS---REPS 474
Query: 362 AGGPLSNLSENTCDNFCLVLEAIQENLRQYKEIRDELNMIVEEVRAIRFNQEQESEVLNR 421
A G LS+ S L ++ +E + K+ + + EE F Q+ ESE R
Sbjct: 475 AAGRLSDSSSEASK---LSSKSAKERRNRRKKRKQKEQSGGEEKDEDEF-QKSESEDSIR 530
Query: 422 RSSTSGSLE-TTSSKDIRQMSQQQDLLS 448
R S+E + + R S Q LLS
Sbjct: 531 RKGFRFSIEGNRLTYEKRYSSPHQSLLS 558
>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
sapiens]
Length = 1980
Score = 85.1 bits (209), Expect = 1e-16
Identities = 67/280 (23%), Positives = 118/280 (42%), Gaps = 53/280 (18%)
Query: 88 LLRHPAFQLLLALLLVINAITIALRTNSYLDQKHY--ELFSTIDDIVLTILLCEVLLGWL 145
++ H F+ + ++++++ +A + Y++Q+ + D + I + E+LL W
Sbjct: 1194 IVEHNWFETFIIFMILLSSGALAFE-DIYIEQRKTIRTILEYADKVFTYIFILEMLLKWT 1252
Query: 146 N-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINY-----TLRALRLVHVCMAVEP 199
GF F+ + W L+F+IV + L+ N + + TLRALR + E
Sbjct: 1253 AYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEG 1312
Query: 200 LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGA--------------------- 238
+ ++ ++ ++P + N++++ L F L+FS+ GV LF
Sbjct: 1313 MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNN 1372
Query: 239 ------------------FVPKHFQNIQVALYTLFICITQDGWVDIY-----SDFQTEKR 275
V +F N+ L T GW+DI S E+
Sbjct: 1373 KTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQP 1432
Query: 276 EYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMK 315
+Y I IYF IFI G+F +NLF+ V+ N Q K
Sbjct: 1433 KYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1472
Score = 67.0 bits (162), Expect = 4e-11
Identities = 54/249 (21%), Positives = 115/249 (46%), Gaps = 35/249 (14%)
Query: 93 AFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNGFWIFW 152
AF +++ +L+ +N +T+ + T++ Q L+ I+ + + CE +L ++
Sbjct: 1523 AFDIVIMMLICLNMVTMMVETDTQSKQMENILY-WINLVFVIFFTCECVLKMFALRHYYF 1581
Query: 153 KDGWNILNFIIVFILLLRFFINEIN-----IPSINYTLRALRLVHVCMAVEP---LARII 204
GWNI +F++V + ++ F+ +I P++ +R R+ + ++ + ++
Sbjct: 1582 TIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLL 1641
Query: 205 RVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPKH---------FQNIQVALYTLF 255
++ S+P + NI +L+ M +FS+FG++ F A+V KH F+ ++ LF
Sbjct: 1642 FALMMSLPALFNIGLLLFLVMFIFSIFGMSNF-AYV-KHEAGIDDMFNFETFGNSMICLF 1699
Query: 256 ICITQDGW-----------VDIYSDFQTEKREYAMEIG----GAIYFTIFITIGAFIGIN 300
T GW D D + + + G G +F +I I I +N
Sbjct: 1700 QITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVN 1759
Query: 301 LFVIVVTTN 309
+++ ++ N
Sbjct: 1760 MYIAIILEN 1768
Score = 58.5 bits (140), Expect = 1e-08
Identities = 50/265 (18%), Positives = 118/265 (44%), Gaps = 31/265 (11%)
Query: 85 IKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCEVLLG 143
+ ++ P L + + +V+N + +A+ + Q +E + ++V T I E+ L
Sbjct: 746 VNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQ--FEHVLAVGNLVFTGIFTAEMFLK 803
Query: 144 WLN-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLAR 202
+ + ++++GWNI + IV + L+ + ++ S+ + R LR+ + + L
Sbjct: 804 LIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNM 863
Query: 203 IIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG-------------AFVPKHFQNIQV 249
+I++I SV + N+ +++ + +F+V G+ LFG +P+ +
Sbjct: 864 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFF 923
Query: 250 ALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG----AIYFTIFITIGAFIGINLFVIV 305
+ + + W++ D ME+ G I F + + IG + +NLF+ +
Sbjct: 924 HSFLIVFRVLCGEWIETMWD--------CMEVAGQAMCLIVFMMVMVIGNLVVLNLFLAL 975
Query: 306 VTTNL--EQMMKAGEQGQQQRITFS 328
+ ++ + + + G+ + S
Sbjct: 976 LLSSFSADNLAATDDDGEMNNLQIS 1000
Score = 57.0 bits (136), Expect = 4e-08
Identities = 34/150 (22%), Positives = 74/150 (49%), Gaps = 3/150 (2%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLGWLN 146
++L H F +++ ++ N + + + F+ I L+ + G+
Sbjct: 127 KILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGI--YTFESLVKIIARGFCI 184
Query: 147 GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRV 206
+ F +D WN L+F ++ + + F+N N+ ++ T R LR + + L I+
Sbjct: 185 DGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALR-TFRVLRALKTISVIPGLKTIVGA 243
Query: 207 ILQSVPDMANIMVLILFFMLVFSVFGVTLF 236
++QSV ++++M+L +F + VF++ G+ LF
Sbjct: 244 LIQSVKKLSDVMILTVFCLSVFALIGLQLF 273
Score = 35.0 bits (79), Expect = 0.15
Identities = 24/86 (27%), Positives = 40/86 (46%), Gaps = 8/86 (9%)
Query: 244 FQNIQVALYTLFICITQDGWVDIYS-DFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
F A LF +TQD W ++Y + + Y I+F + I +G+F +NL
Sbjct: 353 FDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYM------IFFVLVIFVGSFYLVNLI 406
Query: 303 VIVVTTNLEQMMKAG-EQGQQQRITF 327
+ VV E+ +A E+ +Q+ F
Sbjct: 407 LAVVAMAYEEQNQATLEEAEQKEAEF 432
>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
[Homo sapiens]
Length = 1951
Score = 84.3 bits (207), Expect = 2e-16
Identities = 66/276 (23%), Positives = 121/276 (43%), Gaps = 49/276 (17%)
Query: 88 LLRHPAFQLLLALLLVINAITIALRTNSYLDQKHY--ELFSTIDDIVLTILLCEVLLGWL 145
++ H F+ + ++++++ +A + Y++Q+ + D + I + E+LL W+
Sbjct: 1153 IVEHNWFETFIVFMILLSSGALAFE-DIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV 1211
Query: 146 N-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINY-----TLRALRLVHVCMAVEP 199
GF ++ + W L+F+IV + L+ N + + TLRALR + E
Sbjct: 1212 AYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEG 1271
Query: 200 LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAF------------------- 239
+ ++ ++ ++P + N++++ L F L+FS+ GV LF G F
Sbjct: 1272 MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNN 1331
Query: 240 ---------------VPKHFQNIQVALYTLFICITQDGWVDIY---SDFQTEKRE--YAM 279
V +F N+ L T GW+DI D + K + Y
Sbjct: 1332 LSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEE 1391
Query: 280 EIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMK 315
+ +YF IFI G+F +NLF+ V+ N Q K
Sbjct: 1392 NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1427
Score = 63.2 bits (152), Expect = 5e-10
Identities = 53/257 (20%), Positives = 118/257 (45%), Gaps = 33/257 (12%)
Query: 72 DAWDMQEFITHMYIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDI 131
DAW + + ++ + P L + + +V+N + +A+ +Q + T+ ++
Sbjct: 695 DAWLKVKHLVNLIVMD----PFVDLAITICIVLNTLFMAMEHYPMTEQ--FSSVLTVGNL 748
Query: 132 VLT-ILLCEVLLGWLN-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALR 189
V T I E++L + + ++++GWNI + IIV + L+ ++ + S+ + R LR
Sbjct: 749 VFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLR 808
Query: 190 LVHVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG------------ 237
+ + + L +I++I SV + N+ +++ + +F+V G+ LFG
Sbjct: 809 VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIND 868
Query: 238 -AFVPKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG----AIYFTIFIT 292
+P+ N + + + W++ D ME+ G I F + +
Sbjct: 869 DCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWD--------CMEVAGQTMCLIVFMLVMV 920
Query: 293 IGAFIGINLFVIVVTTN 309
IG + +NLF+ ++ ++
Sbjct: 921 IGNLVVLNLFLALLLSS 937
Score = 62.0 bits (149), Expect = 1e-09
Identities = 50/250 (20%), Positives = 114/250 (45%), Gaps = 38/250 (15%)
Query: 94 FQLLLALLLVINAITIALRTNSYLDQKHYE--LFSTIDDIVLTILLCEVLLGWLNGFWIF 151
F + + +L+ +N +T+ + T+ DQ Y + S I+ + + + E +L ++ +
Sbjct: 1479 FDISIMILICLNMVTMMVETD---DQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYY 1535
Query: 152 WKDGWNILNFIIVFILLLRFFINEIN-----IPSINYTLRALRLVHVCMAVEP---LARI 203
+ GWNI +F++V + ++ F+ E+ P++ +R R+ + ++ + +
Sbjct: 1536 FTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTL 1595
Query: 204 IRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPK--------HFQNIQVALYTLF 255
+ ++ S+P + NI +L+ M ++++FG++ F A+V K +F+ ++ LF
Sbjct: 1596 LFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKKEAGIDDMFNFETFGNSMICLF 1654
Query: 256 ICITQDGW----------------VDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGI 299
T GW D + K + G +F +I I + +
Sbjct: 1655 QITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVV 1714
Query: 300 NLFVIVVTTN 309
N+++ V+ N
Sbjct: 1715 NMYIAVILEN 1724
Score = 55.5 bits (132), Expect = 1e-07
Identities = 39/151 (25%), Positives = 79/151 (52%), Gaps = 5/151 (3%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLL-GWL 145
++L H F +L+ ++ N + + L +N K+ E T I L ++L G+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTL-SNPPDWTKNVEY--TFTGIYTFESLIKILARGFC 179
Query: 146 NGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIR 205
+ F +D WN L+F ++ + + F++ N+ ++ T R LR + + L I+
Sbjct: 180 LEDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALR-TFRVLRALKTISVIPGLKTIVG 238
Query: 206 VILQSVPDMANIMVLILFFMLVFSVFGVTLF 236
++QSV ++++M+L +F + VF++ G+ LF
Sbjct: 239 ALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
Score = 41.6 bits (96), Expect = 0.002
Identities = 53/211 (25%), Positives = 94/211 (44%), Gaps = 21/211 (9%)
Query: 244 FQNIQVALYTLFICITQDGWVDIYS-DFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
F A +LF +TQD W ++Y + + Y I+F + I +G+F +NL
Sbjct: 366 FDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYM------IFFVLVIFLGSFYLVNLI 419
Query: 303 VIVVTTNLEQMMKAG-EQGQQQRITFSETGAEEEEENDQLPLVHCVVARS-EKSGLLQEP 360
+ VV E+ +A E+ +Q+ F + + +++ ++ V A S + SG+
Sbjct: 420 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGI---- 475
Query: 361 LAGGPLSNLSENTCDNFCLVLEAIQE--NLRQYKEIRDELNMIVEEVRAIRFNQEQESEV 418
G L L E++ + L ++ +E N R+ + R+ L + R E E V
Sbjct: 476 ---GGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSV 532
Query: 419 LNRRSSTSGSLE-TTSSKDIRQMSQQQDLLS 448
+RSS S++ + D + S Q LLS
Sbjct: 533 --KRSSFLFSMDGNRLTSDKKFCSPHQSLLS 561
>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
[Homo sapiens]
Length = 1951
Score = 84.3 bits (207), Expect = 2e-16
Identities = 66/276 (23%), Positives = 121/276 (43%), Gaps = 49/276 (17%)
Query: 88 LLRHPAFQLLLALLLVINAITIALRTNSYLDQKHY--ELFSTIDDIVLTILLCEVLLGWL 145
++ H F+ + ++++++ +A + Y++Q+ + D + I + E+LL W+
Sbjct: 1153 IVEHNWFETFIVFMILLSSGALAFE-DIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV 1211
Query: 146 N-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINY-----TLRALRLVHVCMAVEP 199
GF ++ + W L+F+IV + L+ N + + TLRALR + E
Sbjct: 1212 AYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEG 1271
Query: 200 LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAF------------------- 239
+ ++ ++ ++P + N++++ L F L+FS+ GV LF G F
Sbjct: 1272 MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNN 1331
Query: 240 ---------------VPKHFQNIQVALYTLFICITQDGWVDIY---SDFQTEKRE--YAM 279
V +F N+ L T GW+DI D + K + Y
Sbjct: 1332 LSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEE 1391
Query: 280 EIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMK 315
+ +YF IFI G+F +NLF+ V+ N Q K
Sbjct: 1392 NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1427
Score = 63.2 bits (152), Expect = 5e-10
Identities = 53/257 (20%), Positives = 118/257 (45%), Gaps = 33/257 (12%)
Query: 72 DAWDMQEFITHMYIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDI 131
DAW + + ++ + P L + + +V+N + +A+ +Q + T+ ++
Sbjct: 695 DAWLKVKHLVNLIVMD----PFVDLAITICIVLNTLFMAMEHYPMTEQ--FSSVLTVGNL 748
Query: 132 VLT-ILLCEVLLGWLN-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALR 189
V T I E++L + + ++++GWNI + IIV + L+ ++ + S+ + R LR
Sbjct: 749 VFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLR 808
Query: 190 LVHVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG------------ 237
+ + + L +I++I SV + N+ +++ + +F+V G+ LFG
Sbjct: 809 VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIND 868
Query: 238 -AFVPKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG----AIYFTIFIT 292
+P+ N + + + W++ D ME+ G I F + +
Sbjct: 869 DCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWD--------CMEVAGQTMCLIVFMLVMV 920
Query: 293 IGAFIGINLFVIVVTTN 309
IG + +NLF+ ++ ++
Sbjct: 921 IGNLVVLNLFLALLLSS 937
Score = 62.0 bits (149), Expect = 1e-09
Identities = 50/250 (20%), Positives = 114/250 (45%), Gaps = 38/250 (15%)
Query: 94 FQLLLALLLVINAITIALRTNSYLDQKHYE--LFSTIDDIVLTILLCEVLLGWLNGFWIF 151
F + + +L+ +N +T+ + T+ DQ Y + S I+ + + + E +L ++ +
Sbjct: 1479 FDISIMILICLNMVTMMVETD---DQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYY 1535
Query: 152 WKDGWNILNFIIVFILLLRFFINEIN-----IPSINYTLRALRLVHVCMAVEP---LARI 203
+ GWNI +F++V + ++ F+ E+ P++ +R R+ + ++ + +
Sbjct: 1536 FTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTL 1595
Query: 204 IRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPK--------HFQNIQVALYTLF 255
+ ++ S+P + NI +L+ M ++++FG++ F A+V K +F+ ++ LF
Sbjct: 1596 LFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKKEAGIDDMFNFETFGNSMICLF 1654
Query: 256 ICITQDGW----------------VDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGI 299
T GW D + K + G +F +I I + +
Sbjct: 1655 QITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVV 1714
Query: 300 NLFVIVVTTN 309
N+++ V+ N
Sbjct: 1715 NMYIAVILEN 1724
Score = 55.5 bits (132), Expect = 1e-07
Identities = 39/151 (25%), Positives = 79/151 (52%), Gaps = 5/151 (3%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLL-GWL 145
++L H F +L+ ++ N + + L +N K+ E T I L ++L G+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTL-SNPPDWTKNVEY--TFTGIYTFESLIKILARGFC 179
Query: 146 NGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIR 205
+ F +D WN L+F ++ + + F++ N+ ++ T R LR + + L I+
Sbjct: 180 LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALR-TFRVLRALKTISVIPGLKTIVG 238
Query: 206 VILQSVPDMANIMVLILFFMLVFSVFGVTLF 236
++QSV ++++M+L +F + VF++ G+ LF
Sbjct: 239 ALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
Score = 41.6 bits (96), Expect = 0.002
Identities = 53/211 (25%), Positives = 94/211 (44%), Gaps = 21/211 (9%)
Query: 244 FQNIQVALYTLFICITQDGWVDIYS-DFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
F A +LF +TQD W ++Y + + Y I+F + I +G+F +NL
Sbjct: 366 FDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYM------IFFVLVIFLGSFYLVNLI 419
Query: 303 VIVVTTNLEQMMKAG-EQGQQQRITFSETGAEEEEENDQLPLVHCVVARS-EKSGLLQEP 360
+ VV E+ +A E+ +Q+ F + + +++ ++ V A S + SG+
Sbjct: 420 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGI---- 475
Query: 361 LAGGPLSNLSENTCDNFCLVLEAIQE--NLRQYKEIRDELNMIVEEVRAIRFNQEQESEV 418
G L L E++ + L ++ +E N R+ + R+ L + R E E V
Sbjct: 476 ---GGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSV 532
Query: 419 LNRRSSTSGSLE-TTSSKDIRQMSQQQDLLS 448
+RSS S++ + D + S Q LLS
Sbjct: 533 --KRSSFLFSMDGNRLTSDKKFCSPHQSLLS 561
>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
[Homo sapiens]
Length = 2000
Score = 84.3 bits (207), Expect = 2e-16
Identities = 66/276 (23%), Positives = 121/276 (43%), Gaps = 49/276 (17%)
Query: 88 LLRHPAFQLLLALLLVINAITIALRTNSYLDQKHY--ELFSTIDDIVLTILLCEVLLGWL 145
++ H F+ + ++++++ +A + Y++Q+ + D + I + E+LL W+
Sbjct: 1202 IVEHNWFETFIVFMILLSSGALAFE-DIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV 1260
Query: 146 N-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINY-----TLRALRLVHVCMAVEP 199
GF ++ + W L+F+IV + L+ N + + TLRALR + E
Sbjct: 1261 AYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEG 1320
Query: 200 LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAF------------------- 239
+ ++ ++ ++P + N++++ L F L+FS+ GV LF G F
Sbjct: 1321 MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNN 1380
Query: 240 ---------------VPKHFQNIQVALYTLFICITQDGWVDIY---SDFQTEKRE--YAM 279
V +F N+ L T GW+DI D + K + Y
Sbjct: 1381 LSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEE 1440
Query: 280 EIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMK 315
+ +YF IFI G+F +NLF+ V+ N Q K
Sbjct: 1441 NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1476
Score = 63.2 bits (152), Expect = 5e-10
Identities = 53/257 (20%), Positives = 118/257 (45%), Gaps = 33/257 (12%)
Query: 72 DAWDMQEFITHMYIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDI 131
DAW + + ++ + P L + + +V+N + +A+ +Q + T+ ++
Sbjct: 744 DAWLKVKHLVNLIVMD----PFVDLAITICIVLNTLFMAMEHYPMTEQ--FSSVLTVGNL 797
Query: 132 VLT-ILLCEVLLGWLN-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALR 189
V T I E++L + + ++++GWNI + IIV + L+ ++ + S+ + R LR
Sbjct: 798 VFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLR 857
Query: 190 LVHVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG------------ 237
+ + + L +I++I SV + N+ +++ + +F+V G+ LFG
Sbjct: 858 VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIND 917
Query: 238 -AFVPKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGG----AIYFTIFIT 292
+P+ N + + + W++ D ME+ G I F + +
Sbjct: 918 DCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWD--------CMEVAGQTMCLIVFMLVMV 969
Query: 293 IGAFIGINLFVIVVTTN 309
IG + +NLF+ ++ ++
Sbjct: 970 IGNLVVLNLFLALLLSS 986
Score = 62.0 bits (149), Expect = 1e-09
Identities = 50/250 (20%), Positives = 114/250 (45%), Gaps = 38/250 (15%)
Query: 94 FQLLLALLLVINAITIALRTNSYLDQKHYE--LFSTIDDIVLTILLCEVLLGWLNGFWIF 151
F + + +L+ +N +T+ + T+ DQ Y + S I+ + + + E +L ++ +
Sbjct: 1528 FDISIMILICLNMVTMMVETD---DQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYY 1584
Query: 152 WKDGWNILNFIIVFILLLRFFINEIN-----IPSINYTLRALRLVHVCMAVEP---LARI 203
+ GWNI +F++V + ++ F+ E+ P++ +R R+ + ++ + +
Sbjct: 1585 FTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTL 1644
Query: 204 IRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPK--------HFQNIQVALYTLF 255
+ ++ S+P + NI +L+ M ++++FG++ F A+V K +F+ ++ LF
Sbjct: 1645 LFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKKEAGIDDMFNFETFGNSMICLF 1703
Query: 256 ICITQDGW----------------VDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGI 299
T GW D + K + G +F +I I + +
Sbjct: 1704 QITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVV 1763
Query: 300 NLFVIVVTTN 309
N+++ V+ N
Sbjct: 1764 NMYIAVILEN 1773
Score = 55.5 bits (132), Expect = 1e-07
Identities = 39/151 (25%), Positives = 79/151 (52%), Gaps = 5/151 (3%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLL-GWL 145
++L H F +L+ ++ N + + L +N K+ E T I L ++L G+
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTL-SNPPDWTKNVEY--TFTGIYTFESLIKILARGFC 179
Query: 146 NGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIR 205
+ F +D WN L+F ++ + + F++ N+ ++ T R LR + + L I+
Sbjct: 180 LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALR-TFRVLRALKTISVIPGLKTIVG 238
Query: 206 VILQSVPDMANIMVLILFFMLVFSVFGVTLF 236
++QSV ++++M+L +F + VF++ G+ LF
Sbjct: 239 ALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
Score = 41.6 bits (96), Expect = 0.002
Identities = 53/211 (25%), Positives = 94/211 (44%), Gaps = 21/211 (9%)
Query: 244 FQNIQVALYTLFICITQDGWVDIYS-DFQTEKREYAMEIGGAIYFTIFITIGAFIGINLF 302
F A +LF +TQD W ++Y + + Y I+F + I +G+F +NL
Sbjct: 366 FDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYM------IFFVLVIFLGSFYLVNLI 419
Query: 303 VIVVTTNLEQMMKAG-EQGQQQRITFSETGAEEEEENDQLPLVHCVVARS-EKSGLLQEP 360
+ VV E+ +A E+ +Q+ F + + +++ ++ V A S + SG+
Sbjct: 420 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGI---- 475
Query: 361 LAGGPLSNLSENTCDNFCLVLEAIQE--NLRQYKEIRDELNMIVEEVRAIRFNQEQESEV 418
G L L E++ + L ++ +E N R+ + R+ L + R E E V
Sbjct: 476 ---GGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSV 532
Query: 419 LNRRSSTSGSLE-TTSSKDIRQMSQQQDLLS 448
+RSS S++ + D + S Q LLS
Sbjct: 533 --KRSSFLFSMDGNRLTSDKKFCSPHQSLLS 561
>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
sapiens]
Length = 1977
Score = 84.0 bits (206), Expect = 3e-16
Identities = 68/282 (24%), Positives = 127/282 (45%), Gaps = 56/282 (19%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYE--LFSTIDDIVLTILLCEVLLGW 144
+++ H F+ + L++++++ +A + Y+++K + D I I + E+LL W
Sbjct: 1176 KIVEHSWFESFIVLMILLSSGALAFE-DIYIERKKTIKIILEYADKIFTYIFILEMLLKW 1234
Query: 145 LN-GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSIN-----YTLRALRLVHVCMAVE 198
+ G+ ++ + W L+F+IV + L+ N + + TLRALR + E
Sbjct: 1235 IAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFE 1294
Query: 199 PLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAF----------------VP 241
+ ++ ++ ++P + N++++ L F L+FS+ GV LF G F VP
Sbjct: 1295 GMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVP 1354
Query: 242 K---------------------HFQNIQVALYTLFICITQDGW-------VDIYSDFQTE 273
+F N+ + +L T GW VD + +
Sbjct: 1355 NRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQP 1414
Query: 274 KREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMK 315
K EY++ + IYF +FI G+F +NLF+ V+ N Q K
Sbjct: 1415 KYEYSLYM--YIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKK 1454
Score = 63.9 bits (154), Expect = 3e-10
Identities = 51/257 (19%), Positives = 115/257 (44%), Gaps = 34/257 (13%)
Query: 85 IKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLGW 144
I L+ + AF + + +L+ +N +T+ + Q E+ I+ + + + E +L
Sbjct: 1497 IFDLVTNQAFDISIMVLICLNMVTMMVEKEGQ-SQHMTEVLYWINVVFIILFTGECVLKL 1555
Query: 145 LNGFWIFWKDGWNILNFIIVFILLLRFFINEIN-----IPSINYTLRALRLVHVCMAVEP 199
++ ++ GWNI +F++V I ++ F+ ++ P++ +R R+ + V+
Sbjct: 1556 ISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKG 1615
Query: 200 ---LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPK--------HFQNIQ 248
+ ++ ++ S+P + NI +L+ M ++++FG++ F A+V K +F+
Sbjct: 1616 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKKEDGINDMFNFETFG 1674
Query: 249 VALYTLFICITQDGWVDIYSDFQTEK----------------REYAMEIGGAIYFTIFIT 292
++ LF T GW + + K + G YF +I
Sbjct: 1675 NSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYII 1734
Query: 293 IGAFIGINLFVIVVTTN 309
I + +N+++ V+ N
Sbjct: 1735 ISFLVVVNMYIAVILEN 1751
Score = 63.5 bits (153), Expect = 4e-10
Identities = 42/161 (26%), Positives = 81/161 (50%), Gaps = 4/161 (2%)
Query: 87 QLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLGWLN 146
++L H F +L+ ++ N I + + + F+ I L+ + G+
Sbjct: 121 KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGI--YTFESLVKILARGFCV 178
Query: 147 GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRV 206
G + F +D WN L+F+++ L F+N N+ ++ T R LR + + L I+
Sbjct: 179 GEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALR-TFRVLRALKTISVIPGLKTIVGA 237
Query: 207 ILQSVPDMANIMVLILFFMLVFSVFGVTLF-GAFVPKHFQN 246
++QSV ++++M+L +F + VF++ G+ LF G K F+N
Sbjct: 238 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRN 278
Score = 58.5 bits (140), Expect = 1e-08
Identities = 48/241 (19%), Positives = 113/241 (46%), Gaps = 29/241 (12%)
Query: 88 LLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLT-ILLCEVLLGWLN 146
++ P L + + +V+N + +A+ + ++ ++ I ++V T I E++L +
Sbjct: 729 IVMDPFVDLAITICIVLNTLFMAMEHHPMTEE--FKNVLAIGNLVFTGIFAAEMVLKLIA 786
Query: 147 -GFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIR 205
+ +++ GWNI + +IV + L+ F+ ++ S+ + R LR+ + + L +I+
Sbjct: 787 MDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIK 846
Query: 206 VILQSVPDMANIMVLILFFMLVFSVFGVTLFG-------------AFVPKHFQNIQVALY 252
+I SV + N+ +++ + +F+V G+ LFG +P+ N +
Sbjct: 847 IIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSF 906
Query: 253 TLFICITQDGWVDIYSDFQTEKREYAMEIGG----AIYFTIFITIGAFIGINLFVIVVTT 308
+ + W++ D ME+ G I + + + IG + +NLF+ ++ +
Sbjct: 907 LIVFRVLCGEWIETMWD--------CMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLS 958
Query: 309 N 309
+
Sbjct: 959 S 959
Score = 46.2 bits (108), Expect = 6e-05
Identities = 49/219 (22%), Positives = 98/219 (44%), Gaps = 14/219 (6%)
Query: 244 FQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFV 303
F A LF +TQD W ++Y + M I+F + I +G+F INL +
Sbjct: 344 FDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYM-----IFFVVVIFLGSFYLINLIL 398
Query: 304 IVVTTNLEQMMKAG-EQGQQQRITFSETGAEEEEENDQLPLVHCVVARSEKSGLLQEPLA 362
VV E+ +A E+ +Q+ + F + ++E ++ + A +E + + + +
Sbjct: 399 AVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAI--AAAAAEYTSIRRSRIM 456
Query: 363 GGPLSNLSENTCDNFCLVLEAIQENL-RQYKEIRDELNMIVEEVRAIRFNQEQESEVLNR 421
G LSE++ + L ++ +E R+ K+ + +L+ E+ A + ++ + + + R
Sbjct: 457 G-----LSESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRR 511
Query: 422 RSSTSGSLETTSSKDIRQMSQQQDLLSALVSMEKVHDSS 460
+S G + + R + Q LS S+ SS
Sbjct: 512 KSFHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSS 550
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.138 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,803,054
Number of Sequences: 37866
Number of extensions: 666801
Number of successful extensions: 3472
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 62
Number of HSP's that attempted gapping in prelim test: 2586
Number of HSP's gapped (non-prelim): 521
length of query: 472
length of database: 18,247,518
effective HSP length: 106
effective length of query: 366
effective length of database: 14,233,722
effective search space: 5209542252
effective search space used: 5209542252
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.