Search of human proteins with 13492973

Search of human proteins with 13492973

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13492973 potassium voltage-gated channel delayed-rectifier
protein S1 [Homo sapiens]
         (526 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13492973 potassium voltage-gated channel delayed-rectifier pr...  1058   0.0  
gi|45383011 potassium voltage-gated channel, delayed-rectifier, ...   467   e-131
gi|25952108 potassium voltage-gated channel delayed-rectifier pr...   431   e-120
gi|27436974 potassium voltage-gated channel, Shab-related subfam...   361   1e-99
gi|4826784 potassium voltage-gated channel, Shab-related subfami...   357   2e-98
gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]    316   4e-86
gi|19424136 potassium channel, subfamily V, member 2 [Homo sapiens]   295   7e-80
gi|6912444 potassium voltage-gated channel, subfamily G, member ...   287   2e-77
gi|27436988 potassium voltage-gated channel, subfamily G, member...   286   2e-77
gi|27436996 potassium voltage-gated channel, subfamily G, member...   281   1e-75
gi|20070166 potassium voltage-gated channel, subfamily F, member...   273   4e-73
gi|19071574 potassium voltage-gated channel, subfamily G, member...   256   3e-68
gi|25952092 potassium voltage-gated channel, shaker-related subf...   254   2e-67
gi|27436993 potassium voltage-gated channel, subfamily G, member...   253   3e-67
gi|4826786 Shaw-related voltage-gated potassium channel protein ...   237   2e-62
gi|163792201 Shaw-related voltage-gated potassium channel protei...   237   2e-62
gi|88758565 potassium voltage-gated channel, shaker-related subf...   236   5e-62
gi|119395748 potassium voltage-gated channel subfamily A member ...   235   7e-62
gi|4504817 potassium voltage-gated channel, shaker-related subfa...   232   6e-61
gi|88758576 Shaw-related voltage-gated potassium channel protein...   231   2e-60
gi|24497462 Shaw-related voltage-gated potassium channel protein...   231   2e-60
gi|24497464 Shaw-related voltage-gated potassium channel protein...   231   2e-60
gi|4826782 potassium voltage-gated channel, shaker-related subfa...   229   4e-60
gi|24497460 Shaw-related voltage-gated potassium channel protein...   228   8e-60
gi|27436981 potassium voltage-gated channel, Shal-related subfam...   226   4e-59
gi|5031819 potassium voltage-gated channel, shaker-related subfa...   224   2e-58
gi|21217561 Shaw-related voltage-gated potassium channel protein...   223   4e-58
gi|21217563 Shaw-related voltage-gated potassium channel protein...   223   4e-58
gi|24497458 Shaw-related voltage-gated potassium channel protein...   223   4e-58
gi|25952087 potassium voltage-gated channel, shaker-related subf...   222   7e-58

>gi|13492973 potassium voltage-gated channel delayed-rectifier
           protein S1 [Homo sapiens]
          Length = 526

 Score = 1058 bits (2736), Expect = 0.0
 Identities = 526/526 (100%), Positives = 526/526 (100%)

Query: 1   MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVR 60
           MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVR
Sbjct: 1   MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVR 60

Query: 61  RQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRT 120
           RQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRT
Sbjct: 61  RQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRT 120

Query: 121 GHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPC 180
           GHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPC
Sbjct: 121 GHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPC 180

Query: 181 PDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIH 240
           PDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIH
Sbjct: 181 PDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIH 240

Query: 241 SLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNF 300
           SLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNF
Sbjct: 241 SLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNF 300

Query: 301 FCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHST 360
           FCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHST
Sbjct: 301 FCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHST 360

Query: 361 GLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMT 420
           GLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMT
Sbjct: 361 GLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMT 420

Query: 421 TVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQ 480
           TVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQ
Sbjct: 421 TVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQ 480

Query: 481 EFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY 526
           EFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY
Sbjct: 481 EFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY 526


>gi|45383011 potassium voltage-gated channel, delayed-rectifier,
           subfamily S, member 2 [Homo sapiens]
          Length = 477

 Score =  467 bits (1202), Expect = e-131
 Identities = 241/472 (51%), Positives = 315/472 (66%), Gaps = 19/472 (4%)

Query: 49  DEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHP 108
           D  +R+NVGG +R+L +  L RFP TRLGRL    S E    LCDDYD+  REFYFDR+P
Sbjct: 16  DGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNP 75

Query: 109 GFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLT-QPHAW 167
             F  +LHFY TG LHV+ ELCVF+F QE +YWG+ E  + +CC   Y  R++  +   W
Sbjct: 76  ELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKW 135

Query: 168 DEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSI 227
           DE SD  S+     DEI     + +++     G  RR+LWL ++NPGYS+ S++FS +SI
Sbjct: 136 DEQSDQESTTSSF-DEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSI 194

Query: 228 SVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEV 287
            VV+ SI  MC++SLP++Q  +            S     +DP    +E+F IAWF+FE+
Sbjct: 195 LVVMGSIITMCLNSLPDFQIPD------------SQGNPGEDPRFEIVEHFGIAWFTFEL 242

Query: 288 SSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLM 347
            +R  +AP    FF + LNLID++S++PFY+TL+  + +  +      +LG+V QV RLM
Sbjct: 243 VARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVV--ESTPTLANLGRVAQVLRLM 300

Query: 348 RIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNT 407
           RIFR+LKLARHSTGLRSLGATLK+SY+EVG+LLLYL+VG+S+FS VAYT EKEE+ G  T
Sbjct: 301 RIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEGLAT 360

Query: 408 IPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQ 467
           IPACWWW TVSMTTVGYGDVVP T AGKL AS CIL GILVV LPIT+IFNKFSHFYRRQ
Sbjct: 361 IPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQ 420

Query: 468 KALEAAVRNSNHQEFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSE 519
           K LE+A+R+    +F D +  +  V+       +  S      ++   +PSE
Sbjct: 421 KQLESAMRSC---DFGDGMKEVPSVNLRDYYAHKVKSLMASLTNMSRSSPSE 469


>gi|25952108 potassium voltage-gated channel delayed-rectifier
           protein S3 [Homo sapiens]
          Length = 491

 Score =  431 bits (1107), Expect = e-120
 Identities = 217/427 (50%), Positives = 295/427 (69%), Gaps = 20/427 (4%)

Query: 47  RSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDR 106
           + +E + +NVGG ++ +    L RFP TRLG+L    SEE    LCDDY  A +E+YFDR
Sbjct: 12  QDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDR 71

Query: 107 HPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERR-LTQPH 165
           +P  F  +L+FY TG LHV++ELCVF+F QE +YWG+ E  + +CC  RY ER+      
Sbjct: 72  NPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHEK 131

Query: 166 AWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCV 225
            WD+ S   S+ D   +E S  ++EL ++   R G+LR+++W+ MENP Y L +KL +  
Sbjct: 132 DWDQKSHDVST-DSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAYCLSAKLIAIS 190

Query: 226 SISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSF 285
           S+SVVLASI AMC+HS+ E+Q               + +G  DDPVL  +E  CIAWF+ 
Sbjct: 191 SLSVVLASIVAMCVHSMSEFQ---------------NEDGEVDDPVLEGVEIACIAWFTG 235

Query: 286 EVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFR 345
           E++ RL  AP  + F+ +PLN+ID VS++PFY TL   V   ++  ++  ++GKVVQ+ R
Sbjct: 236 ELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATL--AVDTKEEESEDIENMGKVVQILR 293

Query: 346 LMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDV-G 404
           LMRIFR+LKLARHS GLRSLGATL+HSY EVG+LLL+L+VG+S+FS + Y+ EK++    
Sbjct: 294 LMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSS 353

Query: 405 FNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFY 464
             +IP CWWW T+SMTTVGYGD  PVT+AGKL AS CI+ GILVVALPITIIFNKFS +Y
Sbjct: 354 LTSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYY 413

Query: 465 RRQKALE 471
           ++QK ++
Sbjct: 414 QKQKDID 420


>gi|27436974 potassium voltage-gated channel, Shab-related
           subfamily, member 2 [Homo sapiens]
          Length = 911

 Score =  361 bits (926), Expect = 1e-99
 Identities = 193/511 (37%), Positives = 302/511 (59%), Gaps = 39/511 (7%)

Query: 21  PTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQ 80
           P  L  +++ + +S  P P   IR +     +++NVGG+  ++  R L R P TRLG+L+
Sbjct: 6   PPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLR 65

Query: 81  AAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADY 140
              + E    +CDDY+    E++FDRHPG F S+L+FYRTG LH+++E+C  +FGQE DY
Sbjct: 66  DCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDY 125

Query: 141 WGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCG 200
           WG+ E  L +CC+ARY +++         +++T              +RE   +    C 
Sbjct: 126 WGIDEIYLESCCQARYHQKKEQMNEELRREAETMR------------EREGEEFDNTCCP 173

Query: 201 RLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAG 260
             R++LW  +E P  S+ +K+ + VSI  ++ S  A+ +++LPE Q  +           
Sbjct: 174 DKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQ------- 226

Query: 261 RSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTL 320
                + D+  L  +E  CIAWF+ E   R L +P+   FF  PLN+ID++++LP+Y+T+
Sbjct: 227 -----LNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTI 281

Query: 321 LAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILL 380
              +   ++   +F ++ +VVQ+FR+MRI R+LKLARHSTGL+SLG TL+ SY E+G+L+
Sbjct: 282 F--LTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLI 339

Query: 381 LYLAVGVSVFSGVAYTAEKEED-VGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAAS 439
           L+LA+G+ +FS + + AEK+ED   F +IPA +WW T++MTTVGYGD+ P T+ GK+   
Sbjct: 340 LFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGG 399

Query: 440 GCILGGILVVALPITIIFNKFSHFYRRQK----------ALEAAVRNSN--HQEFEDLLS 487
            C + G+LV+ALPI II N FS FY+ QK          ALE A RN +      +D  +
Sbjct: 400 LCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFA 459

Query: 488 SIDGVSEASLETSRETSQEGQSADLESQAPS 518
               + + ++E + E++    SAD    +PS
Sbjct: 460 RSMELIDVAVEKAGESANTKDSADDNHLSPS 490


>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
           member 1 [Homo sapiens]
          Length = 858

 Score =  357 bits (915), Expect = 2e-98
 Identities = 183/455 (40%), Positives = 279/455 (61%), Gaps = 30/455 (6%)

Query: 22  TPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQA 81
           T  G RST +     P P   +R +     +R+NVGG+  ++  R L R P TRLG+L+ 
Sbjct: 6   TKHGSRSTSSLP---PEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRD 62

Query: 82  AASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYW 141
             + +    +CDDY     E++FDRHPG F S+L+FYRTG LH+++E+C  +F QE DYW
Sbjct: 63  CNTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYW 122

Query: 142 GLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGR 201
           G+ E  L +CC+ARY +++         +++T              +RE   +    C  
Sbjct: 123 GIDEIYLESCCQARYHQKKEQMNEELKREAETLR------------EREGEEFDNTCCAE 170

Query: 202 LRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGR 261
            R++LW  +E P  S+ +K+ + +SI  ++ S  A+ +++LPE Q+ +          G+
Sbjct: 171 KRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLD--------EFGQ 222

Query: 262 SPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLL 321
           S     D+P L  +E  CIAWF+ E   R L +P    FF  PLN ID++++LP+Y+T+ 
Sbjct: 223 S----TDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIF 278

Query: 322 AGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL 381
             +   ++   +F ++ +VVQ+FR+MRI R+LKLARHSTGL+SLG TL+ SY E+G+L+L
Sbjct: 279 --LTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLIL 336

Query: 382 YLAVGVSVFSGVAYTAEK-EEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASG 440
           +LA+G+ +FS + + AEK E+D  F +IPA +WW T++MTTVGYGD+ P T+ GK+    
Sbjct: 337 FLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGL 396

Query: 441 CILGGILVVALPITIIFNKFSHFYRRQKALEAAVR 475
           C + G+LV+ALPI II N FS FY+ QK  E A++
Sbjct: 397 CCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIK 431


>gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]
          Length = 500

 Score =  316 bits (809), Expect = 4e-86
 Identities = 190/475 (40%), Positives = 259/475 (54%), Gaps = 50/475 (10%)

Query: 17  KVVLPTPLGGRS-----TETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARF 71
           + +L +PL   S     +  F SE  G    +      +   VNVGG R  LS +AL+ F
Sbjct: 6   RALLDSPLDSGSLTSLDSSVFCSEGEGEPLAL-----GDCFTVNVGGSRFVLSQQALSCF 60

Query: 72  PGTRLGRLQ----------AAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTG 121
           P TRLG+L           A A+      LCDD +    E++FDR    F  +LH+YRTG
Sbjct: 61  PHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYFFDRSSQAFRYVLHYYRTG 120

Query: 122 HLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCP 181
            LHV+++LC  +F QE  YWG+ E ++ +CCR RY  R+        E S+T        
Sbjct: 121 RLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRK--------ELSETLDFKKDTE 172

Query: 182 DEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHS 241
           D+ S  + E   +    C  +R++LW  +E PG S  +++F  +SI  V+ SI  M + S
Sbjct: 173 DQESQHESE-QDFSQGPCPTVRQKLWNILEKPGSSTAARIFGVISIIFVVVSIINMALMS 231

Query: 242 LPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFF 301
                               +     D  +L  LEY CI+WF+ E   R L       F 
Sbjct: 232 --------------------AELSWLDLQLLEILEYVCISWFTGEFVLRFLCVRDRCRFL 271

Query: 302 CHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTG 361
               N+ID++++LPFY+TLL     G Q  +E  ++G++VQV RL+R  R+LKL RHSTG
Sbjct: 272 RKVPNIIDLLAILPFYITLLVESLSGSQTTQELENVGRIVQVLRLLRALRMLKLGRHSTG 331

Query: 362 LRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKE-EDVGFNTIPACWWWGTVSMT 420
           LRSLG T+   Y EVG+LLL+L+VG+S+FS V Y AE+   D  F ++P  WWW T SMT
Sbjct: 332 LRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTTFTSVPCAWWWATTSMT 391

Query: 421 TVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVR 475
           TVGYGD+ P T  GK+ A  CIL GILV+ALPI II ++FS  Y   K  EAAVR
Sbjct: 392 TVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTLKLKEAAVR 446


>gi|19424136 potassium channel, subfamily V, member 2 [Homo sapiens]
          Length = 545

 Score =  295 bits (755), Expect = 7e-80
 Identities = 173/428 (40%), Positives = 241/428 (56%), Gaps = 27/428 (6%)

Query: 52  LRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFF 111
           L VNVGG   QL    LA FP TRLGRL  + S  +   LCDDY+E   E++FDR P  F
Sbjct: 99  LNVNVGGHSYQLDYCELAGFPKTRLGRLATSTSRSRQLSLCDDYEEQTDEYFFDRDPAVF 158

Query: 112 LSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERR--LTQPHAWDE 169
             + +FY +G L VLD LC   F +E  YWG+       CCR  + ERR  L++      
Sbjct: 159 QLVYNFYLSGVLLVLDGLCPRRFLEELGYWGVRLKYTPRCCRICFEERRDELSERLKIQH 218

Query: 170 DSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISV 229
           +    + V    +E  ++ R++  YG       RRRLW  ME P  S+ +K     S + 
Sbjct: 219 ELRAQAQV----EEAEELFRDMRFYGPQ-----RRRLWNLMEKPFSSVAAKAIGVASSTF 269

Query: 230 VLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSS 289
           VL S+ A+ ++++ E Q            +G+   G    P+L  +E  C+ +F+ E   
Sbjct: 270 VLVSVVALALNTVEEMQQH----------SGQGEGGPDLRPILEHVEMLCMGFFTLEYLL 319

Query: 290 RLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGD--QGGKEFGHLGK---VVQVF 344
           RL   P  R F    LNL+D+V++LP YL LL     G+  Q G+  G +GK   V++V 
Sbjct: 320 RLASTPDLRRFARSALNLVDLVAILPLYLQLLLECFTGEGHQRGQTVGSVGKVGQVLRVM 379

Query: 345 RLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKE-EDV 403
           RLMRIFR+LKLARHSTGLR+ G TL+  Y++VG LLL++A+G+  FS   Y+ E +    
Sbjct: 380 RLMRIFRILKLARHSTGLRAFGFTLRQCYQQVGCLLLFIAMGIFTFSAAVYSVEHDVPST 439

Query: 404 GFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHF 463
            F TIP  WWW  VS++TVGYGD+ P T  G+  A  CI  GI++  +PI+I++NKFS +
Sbjct: 440 NFTTIPHSWWWAAVSISTVGYGDMYPETHLGRFFAFLCIAFGIILNGMPISILYNKFSDY 499

Query: 464 YRRQKALE 471
           Y + KA E
Sbjct: 500 YSKLKAYE 507


>gi|6912444 potassium voltage-gated channel, subfamily G, member 2
           [Homo sapiens]
          Length = 466

 Score =  287 bits (734), Expect = 2e-77
 Identities = 174/462 (37%), Positives = 247/462 (53%), Gaps = 27/462 (5%)

Query: 37  PGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYD 96
           PG   G R R     + +NVGG R +L+  ALAR P  RL RL+A    +   R+CDDYD
Sbjct: 8   PGGGGGTRARH----VIINVGGCRVRLAWAALARCPLARLERLRACRGHDDLLRVCDDYD 63

Query: 97  EAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARY 156
            +  EF+FDR P  F +++   R G L +L   C  AF  E  YWG+ E  L  CC  R 
Sbjct: 64  VSRDEFFFDRSPCAFRAIVALLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCCLRRL 123

Query: 157 LERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYS 216
             R      A    ++  +   P         R L   G  R  R RRRL   ++NP   
Sbjct: 124 RRREEEAAEARAGPTERGAQGSPA--------RALGPRG--RLQRGRRRLRDVVDNPHSG 173

Query: 217 LPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLE 276
           L  KLF+CVS+S V  +   +C+ ++P+ +A E     +                L  LE
Sbjct: 174 LAGKLFACVSVSFVAVTAVGLCLSTMPDIRAEEERGECSPKCRS-----------LFVLE 222

Query: 277 YFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGH 336
             C+AWFSFE   R L A S   F   PLN+IDI+++LPFY++LL G+A G  G K    
Sbjct: 223 TVCVAWFSFEFLLRSLQAESKCAFLRAPLNIIDILALLPFYVSLLLGLAAGPGGTKLLER 282

Query: 337 LGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYT 396
            G V+++ R +R+  V++LARHS GLRSLG T++   RE G+LLL+L V +++F+ + + 
Sbjct: 283 AGLVLRLLRALRVLYVMRLARHSLGLRSLGLTMRRCAREFGLLLLFLCVAMALFAPLVHL 342

Query: 397 AEKEEDV--GFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPIT 454
           AE+E      F+++PA +WW  +SMTTVGYGD+VP ++ G++ A   IL GIL++A P+T
Sbjct: 343 AERELGARRDFSSVPASYWWAVISMTTVGYGDMVPRSLPGQVVALSSILSGILLMAFPVT 402

Query: 455 IIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSIDGVSEAS 496
            IF+ FS  Y   K  +    +      ED   S     ++S
Sbjct: 403 SIFHTFSRSYSELKEQQQRAASPEPALQEDSTHSATATEDSS 444


>gi|27436988 potassium voltage-gated channel, subfamily G, member 1
           [Homo sapiens]
          Length = 513

 Score =  286 bits (733), Expect = 2e-77
 Identities = 160/427 (37%), Positives = 236/427 (55%), Gaps = 34/427 (7%)

Query: 54  VNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLS 113
           +NVGG++  L    L  FP TRLG+L+A  + +    +CDDYD    EF+FDR+PG F +
Sbjct: 67  INVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRNPGAFGT 126

Query: 114 LLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLER-----RLTQPHAWD 168
           +L F R G L +L E+C  +F +E  YWG+ E+ L  CC+ RYL++      + +    D
Sbjct: 127 ILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMVEREEED 186

Query: 169 EDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSIS 228
           +  D+       P E           G  R GR  RRL   +E P   LP K+F+C+S+ 
Sbjct: 187 DALDSEGRDSEGPAE-----------GEGRLGRCMRRLRDMVERPHSGLPGKVFACLSVL 235

Query: 229 VVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVS 288
            V  +   + + +LP  +  E     + +              +  +E  C+ WFS E  
Sbjct: 236 FVTVTAVNLSVSTLPSLREEEEQGHCSQMCHN-----------VFIVESVCVGWFSLEFL 284

Query: 289 SRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLA-GVALGDQ----GGKEFGHLGKVVQV 343
            RL+ APS   F   PL LID+V++LP+Y+TLL  G A G +    G      +G V++V
Sbjct: 285 LRLIQAPSKFAFLRSPLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRV 344

Query: 344 FRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKE--E 401
            R +RI  V++LARHS GL++LG T +   RE G+LLL+L V +++F+ + Y  E E  +
Sbjct: 345 LRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMAD 404

Query: 402 DVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFS 461
              F +IPAC+WW  ++MTTVGYGD+VP +  G++ A   IL GIL++A P+T IF+ FS
Sbjct: 405 SPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFS 464

Query: 462 HFYRRQK 468
             Y   K
Sbjct: 465 RSYLELK 471


>gi|27436996 potassium voltage-gated channel, subfamily G, member 4
           [Homo sapiens]
          Length = 519

 Score =  281 bits (718), Expect = 1e-75
 Identities = 167/436 (38%), Positives = 250/436 (57%), Gaps = 34/436 (7%)

Query: 54  VNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLS 113
           +NVGG R  L    L RFP +RL +L+   S E+  +LCDDYDE ++EF+FDR P  F  
Sbjct: 63  INVGGRRYLLPWSTLDRFPLSRLSKLRLCRSYEEIVQLCDDYDEDSQEFFFDRSPSAFGV 122

Query: 114 LLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDT 173
           ++ F   G L +L E+C  +F +E  YWG+ E  L  CC  R L R+L       E+ + 
Sbjct: 123 IVSFLAAGKLVLLQEMCALSFQEELAYWGIEEAHLERCC-LRKLLRKL-------EELEE 174

Query: 174 PSSVDPCPDEISDVQRELARYG--AARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVL 231
            + +    +++   QRE  R    ++R G    RL   +ENP   LP K+F+C+SI  V 
Sbjct: 175 LAKLH--REDVLRQQRETRRPASHSSRWGLCMNRLREMVENPQSGLPGKVFACLSILFVA 232

Query: 232 ASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRL 291
            +  ++C+ ++P+ +A E              E  R    +  +E  C+AWFS E   R 
Sbjct: 233 TTAVSLCVSTMPDLRAEEDQG-----------ECSRKCYYIFIVETICVAWFSLEFCLRF 281

Query: 292 LLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFG-----HLGKVVQVFRL 346
           + A     FF  PLN+IDI+++ P+Y++L       + G +  G      +G V++V R 
Sbjct: 282 VQAQDKCQFFQGPLNIIDILAISPYYVSLAVSEEPPEDGERPSGSSYLEKVGLVLRVLRA 341

Query: 347 MRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEED--VG 404
           +RI  V++LARHS GL++LG T++   RE G+LLL+LAV +++FS + Y AEKE    + 
Sbjct: 342 LRILYVMRLARHSLGLQTLGLTVRRCTREFGLLLLFLAVAITLFSPLVYVAEKESGRVLE 401

Query: 405 FNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFY 464
           F +IPA +WW  +SMTTVGYGD+VP +V G++ A   IL GIL++A P T IF+ FSH Y
Sbjct: 402 FTSIPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILIMAFPATSIFHTFSHSY 461

Query: 465 ----RRQKALEAAVRN 476
               + Q+ L+A +R+
Sbjct: 462 LELKKEQEQLQARLRH 477


>gi|20070166 potassium voltage-gated channel, subfamily F, member 1
           [Homo sapiens]
          Length = 494

 Score =  273 bits (697), Expect = 4e-73
 Identities = 169/493 (34%), Positives = 256/493 (51%), Gaps = 52/493 (10%)

Query: 37  PGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQ--AAASEEQARRLCDD 94
           P P +       D  + VNVGGVR+ L    L+++P TRL  L    A   +    LCDD
Sbjct: 10  PEPGSQSSAASDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDD 69

Query: 95  YDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRA 154
           YD   REFYFDR P  F  ++  Y  G +H+   +C   F  E D+W +    L  CC++
Sbjct: 70  YDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKS 129

Query: 155 RYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPG 214
              E+R       +E  +    V    D++     E       R  R ++ +W  +E P 
Sbjct: 130 HLSEKR-------EELEEIARRVQLILDDLGVDAAE------GRWRRCQKCVWKFLEKPE 176

Query: 215 YSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVR-DDPVLR 273
            S P+++ + +S  ++L S   MC+ ++PE Q  +A             EG R + P L 
Sbjct: 177 SSCPARVVAVLSFLLILVSSVVMCMGTIPELQVLDA-------------EGNRVEHPTLE 223

Query: 274 RLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGK- 332
            +E  CI WF+ E   RL  +P+  +F    +N++D++++LPFY++L     L   G + 
Sbjct: 224 NVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSL----TLTHLGARM 279

Query: 333 -EFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFS 391
            E  ++ + VQ  R+MRI R+ KLARHS+GL++L   LK S++E+G+LL+YLAVG+ VFS
Sbjct: 280 MELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFS 339

Query: 392 GVAYTAEKEE-DVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVA 450
            + YT E+   +  F +IP  +WW  ++MTTVGYGD+ P T  GKL A+   L G++ +A
Sbjct: 340 ALGYTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIA 399

Query: 451 LPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSIDGVSEASLETSRETSQEGQSA 510
           LPI  I N F  +Y +Q+ LE A +  +  E  +L SS  G              EG++ 
Sbjct: 400 LPIHPIINNFVRYYNKQRVLETAAK--HELELMELNSSSGG--------------EGKTG 443

Query: 511 DLESQAPSEPPHP 523
              S   + PP P
Sbjct: 444 GSRSDLDNLPPEP 456


>gi|19071574 potassium voltage-gated channel, subfamily G, member 3
           isoform 1 [Homo sapiens]
          Length = 436

 Score =  256 bits (655), Expect = 3e-68
 Identities = 160/446 (35%), Positives = 235/446 (52%), Gaps = 41/446 (9%)

Query: 54  VNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLS 113
           +NVGG R  LS   L  FP  R+ RL    SE     +CDDYD    E++FDRH   F  
Sbjct: 13  LNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGF 72

Query: 114 LLHFYRT-GHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSD 172
           +L + R  G L     +C  +F  E  YWGL    L  CC     +RRL      D  SD
Sbjct: 73  ILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCC-----QRRLD-----DRMSD 122

Query: 173 TPSSVDPCPDEISDVQRELARYGAARCGRLRR---RLWLTMENPGYSLPSKLFSCVSISV 229
           T +      DE   + R+ AR G A     RR   R+  T E P  SL +++ + VS+  
Sbjct: 123 TYTFYSA--DEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVF 180

Query: 230 VLASIAAMCIHSLPEYQAREAAA--------AVAAVAAGRSPEGVRDDPVLRRLEYFCIA 281
           V+ S+  +C  +LP++  R AAA        +  +   GR P G+        +E  CI 
Sbjct: 181 VIVSMVVLCASTLPDW--RNAAADNRSLDDRSRYSAGPGREPSGI--------IEAICIG 230

Query: 282 WFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVV 341
           WF+ E   R +++ +   F   PLN+ID++++ P+Y+++L  V  G+    +    G  +
Sbjct: 231 WFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENS--QLQRAGVTL 288

Query: 342 QVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEE 401
           +V R+MRIF V+KLARH  GL++LG TLK  YRE+ +LL+++ V +++FS ++   E   
Sbjct: 289 RVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGL 348

Query: 402 DV-----GFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITII 456
           D+      F +IPA  WW  +SMTTVGYGD+ P+TV G++    C++ GI+++ALPIT I
Sbjct: 349 DLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFI 408

Query: 457 FNKFSHFYRRQKALEAAVRNSNHQEF 482
           ++ F   Y   K   A    S   EF
Sbjct: 409 YHSFVQCYHELKFRSARYSRSLSTEF 434


>gi|25952092 potassium voltage-gated channel, shaker-related
           subfamily, member 7 [Homo sapiens]
          Length = 456

 Score =  254 bits (648), Expect = 2e-67
 Identities = 165/441 (37%), Positives = 243/441 (55%), Gaps = 60/441 (13%)

Query: 50  EALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPG 109
           E L +NV G+R +  AR L RFP T LG        + ARR    YD+A RE++FDRH  
Sbjct: 13  ERLVLNVAGLRFETRARTLGRFPDTLLG--------DPARR-GRFYDDARREYFFDRHRP 63

Query: 110 FFLSLLHFYRTG-HLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWD 168
            F ++L++Y++G  L     + +  F +E  ++GLG  ALA          RL +    D
Sbjct: 64  SFDAVLYYYQSGGRLRRPAHVPLDVFLEEVAFYGLGAAALA----------RLRE----D 109

Query: 169 EDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSIS 228
           E    P             +R L R   AR      +LWL  E P  S  +++ + VS+ 
Sbjct: 110 EGCPVPP------------ERPLPRRAFAR------QLWLLFEFPESSQAARVLAVVSVL 151

Query: 229 VVLASIAAMCIHSLPEYQA-REAAAAVAAVAAGRSPEGVR--------------DDPVLR 273
           V+L SI   C+ +LP+++  R+     AA AAG  P  +               +DP   
Sbjct: 152 VILVSIVVFCLETLPDFRDDRDGTGLAAAAAAGPFPAPLNGSSQMPGNPPRLPFNDPFFV 211

Query: 274 RLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKE 333
            +E  CI WFSFE+  RLL+ PS   FF + +NLID V++LP+++ L   +A     G++
Sbjct: 212 -VETLCICWFSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQRGVGQQ 270

Query: 334 FGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGV 393
              L  +++V RL+R+FR+ KL+RHS GL+ LG TL+ S RE+G+L+ +L +GV +FS  
Sbjct: 271 AMSLA-ILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSA 329

Query: 394 AYTAEKEE-DVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALP 452
            Y AE +  D  F +IP  +WW  V+MTTVGYGD+ PVTV GK+  S C + G+L ++LP
Sbjct: 330 VYFAEVDRVDSHFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLP 389

Query: 453 ITIIFNKFSHFYRRQKALEAA 473
           + +I + FS+FY R+   E A
Sbjct: 390 VPVIVSNFSYFYHRETEGEEA 410


>gi|27436993 potassium voltage-gated channel, subfamily G, member 3
           isoform 2 [Homo sapiens]
          Length = 425

 Score =  253 bits (646), Expect = 3e-67
 Identities = 158/438 (36%), Positives = 232/438 (52%), Gaps = 36/438 (8%)

Query: 54  VNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLS 113
           +NVGG R  LS   L  FP  R+ RL    SE     +CDDYD    E++FDRH   F  
Sbjct: 13  LNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGF 72

Query: 114 LLHFYRT-GHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSD 172
           +L + R  G L     +C  +F  E  YWGL    L  CC     +RRL      D  SD
Sbjct: 73  ILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCC-----QRRLD-----DRMSD 122

Query: 173 TPSSVDPCPDEISDVQRELARYGAARCGRLRR---RLWLTMENPGYSLPSKLFSCVSISV 229
           T +      DE   + R+ AR G A     RR   R+  T E P  SL +++ + VS+  
Sbjct: 123 TYTFYSA--DEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVF 180

Query: 230 VLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSS 289
           V+ S+  +C  +LP++  R AAA   ++           D   R +E  CI WF+ E   
Sbjct: 181 VIVSMVVLCASTLPDW--RNAAADNRSL-----------DDRSRIIEAICIGWFTAECIV 227

Query: 290 RLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRI 349
           R +++ +   F   PLN+ID++++ P+Y+++L  V  G+    +    G  ++V R+MRI
Sbjct: 228 RFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENS--QLQRAGVTLRVLRMMRI 285

Query: 350 FRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDV-----G 404
           F V+KLARH  GL++LG TLK  YRE+ +LL+++ V +++FS ++   E   D+      
Sbjct: 286 FWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKD 345

Query: 405 FNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFY 464
           F +IPA  WW  +SMTTVGYGD+ P+TV G++    C++ GI+++ALPIT I++ F   Y
Sbjct: 346 FTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCY 405

Query: 465 RRQKALEAAVRNSNHQEF 482
              K   A    S   EF
Sbjct: 406 HELKFRSARYSRSLSTEF 423


>gi|4826786 Shaw-related voltage-gated potassium channel protein 1
           isoform B [Homo sapiens]
          Length = 511

 Score =  237 bits (604), Expect = 2e-62
 Identities = 146/445 (32%), Positives = 217/445 (48%), Gaps = 39/445 (8%)

Query: 50  EALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPG 109
           E + +NVGG R Q     L   PGTRL  L    +         DYD  A EF+FDRHPG
Sbjct: 8   ERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRHPG 62

Query: 110 FFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQP----- 164
            F  +L++YRTG LH   ++C   + +E  +WG+ E  +  CC   Y + R  +      
Sbjct: 63  VFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSF 122

Query: 165 -------HAWDEDSDTPSSVDPCPDEISDVQR-ELARYGAARCG----RLRRRLWLTMEN 212
                   A D D+D P       DE+   +R  L+     R G    R + R+W   E+
Sbjct: 123 GGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFED 182

Query: 213 PGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRD---D 269
           P  S  ++  +  S+  +L SI   C+ +   +        +  V  G      R+   +
Sbjct: 183 PYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETE 242

Query: 270 PVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQ 329
             L  +E  C+ WF+FE   R++  P+   F  + LN+ID V++LPFYL     V L   
Sbjct: 243 AFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLE----VGLSGL 298

Query: 330 GGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSV 389
             K    +   ++V R +RI R+ KL RH  GLR LG TL+ S  E  +L+++LA+GV +
Sbjct: 299 SSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLI 358

Query: 390 FSGVAYTAEK----------EEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAAS 439
           F+ + Y AE+           E   F  IP  +WW  V+MTT+GYGD+ P T +G L  +
Sbjct: 359 FATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGA 418

Query: 440 GCILGGILVVALPITIIFNKFSHFY 464
            C L G+L +A+P+ +I N F  +Y
Sbjct: 419 LCALAGVLTIAMPVPVIVNNFGMYY 443


>gi|163792201 Shaw-related voltage-gated potassium channel protein 1
           isoform A [Homo sapiens]
          Length = 585

 Score =  237 bits (604), Expect = 2e-62
 Identities = 146/445 (32%), Positives = 217/445 (48%), Gaps = 39/445 (8%)

Query: 50  EALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPG 109
           E + +NVGG R Q     L   PGTRL  L    +         DYD  A EF+FDRHPG
Sbjct: 8   ERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRHPG 62

Query: 110 FFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQP----- 164
            F  +L++YRTG LH   ++C   + +E  +WG+ E  +  CC   Y + R  +      
Sbjct: 63  VFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSF 122

Query: 165 -------HAWDEDSDTPSSVDPCPDEISDVQR-ELARYGAARCG----RLRRRLWLTMEN 212
                   A D D+D P       DE+   +R  L+     R G    R + R+W   E+
Sbjct: 123 GGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFED 182

Query: 213 PGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRD---D 269
           P  S  ++  +  S+  +L SI   C+ +   +        +  V  G      R+   +
Sbjct: 183 PYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETE 242

Query: 270 PVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQ 329
             L  +E  C+ WF+FE   R++  P+   F  + LN+ID V++LPFYL     V L   
Sbjct: 243 AFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLE----VGLSGL 298

Query: 330 GGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSV 389
             K    +   ++V R +RI R+ KL RH  GLR LG TL+ S  E  +L+++LA+GV +
Sbjct: 299 SSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLI 358

Query: 390 FSGVAYTAEK----------EEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAAS 439
           F+ + Y AE+           E   F  IP  +WW  V+MTT+GYGD+ P T +G L  +
Sbjct: 359 FATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGA 418

Query: 440 GCILGGILVVALPITIIFNKFSHFY 464
            C L G+L +A+P+ +I N F  +Y
Sbjct: 419 LCALAGVLTIAMPVPVIVNNFGMYY 443


>gi|88758565 potassium voltage-gated channel, shaker-related
           subfamily, member 3 [Homo sapiens]
          Length = 575

 Score =  236 bits (601), Expect = 5e-62
 Identities = 150/468 (32%), Positives = 247/468 (52%), Gaps = 55/468 (11%)

Query: 50  EALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPG 109
           E + +N+ G+R +   + L +FP T LG           +R    +D    E++FDR+  
Sbjct: 104 ERVVINISGLRFETQLKTLCQFPETLLG---------DPKRRMRYFDPLRNEYFFDRNRP 154

Query: 110 FFLSLLHFYRTG-HLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWD 168
            F ++L++Y++G  +     + +  F +E  ++ LGE A+                  + 
Sbjct: 155 SFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAM----------------EKFR 198

Query: 169 EDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSIS 228
           ED             + + +R L R         +R++WL  E P  S P++  + VS+ 
Sbjct: 199 EDEGF----------LREEERPLPRRD------FQRQVWLLFEYPESSGPARGIAIVSVL 242

Query: 229 VVLASIAAMCIHSLPEYQAREAAAAVAAV----AAGRSPEGVR------DDPVLRRLEYF 278
           V+L SI   C+ +LPE++  +   A  +     AAG S  G R       DP    +E  
Sbjct: 243 VILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFV-VETL 301

Query: 279 CIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLG 338
           CI WFSFE+  R    PS   F  + +NLIDIV+++P+++TL   +A     G++   L 
Sbjct: 302 CIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLA 361

Query: 339 KVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAE 398
            +++V RL+R+FR+ KL+RHS GL+ LG TLK S RE+G+L+ +L +GV +FS   Y AE
Sbjct: 362 -ILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE 420

Query: 399 KEEDV-GFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIF 457
            ++   GF++IP  +WW  V+MTTVGYGD+ PVT+ GK+  S C + G+L +ALP+ +I 
Sbjct: 421 ADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIV 480

Query: 458 NKFSHFYRRQKALEAAVRNSNHQEFEDLLSSIDGVSEASLETSRETSQ 505
           + F++FY R+   E   +  +    + L SS + + +A   ++   S+
Sbjct: 481 SNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSE 528


>gi|119395748 potassium voltage-gated channel subfamily A member 1
           [Homo sapiens]
          Length = 495

 Score =  235 bits (600), Expect = 7e-62
 Identities = 147/462 (31%), Positives = 244/462 (52%), Gaps = 61/462 (13%)

Query: 22  TPLGGRSTETFVSEFPG-PDTGIRWRRSD-------EALRVNVGGVRRQLSARALARFPG 73
           T + G + +   S  PG P  G   R++D       E + +N+ G+R +   + LA+FP 
Sbjct: 2   TVMSGENVDE-ASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPN 60

Query: 74  TRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTG-HLHVLDELCVF 132
           T LG           ++    +D    E++FDR+   F ++L++Y++G  L     + + 
Sbjct: 61  TLLGN---------PKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLD 111

Query: 133 AFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELA 192
            F +E  ++ LGE A+           +  +   + ++ + P      P++         
Sbjct: 112 MFSEEIKFYELGEEAM----------EKFREDEGFIKEEERP-----LPEK--------- 147

Query: 193 RYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAA 252
                     +R++WL  E P  S P+++ + VS+ V+L SI   C+ +LPE +  +   
Sbjct: 148 --------EYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFT 199

Query: 253 AVAAVAAGRSP---EGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLID 309
                    +      +  DP    +E  CI WFSFE+  R    PS  +FF + +N ID
Sbjct: 200 GTVHRIDNTTVIYNSNIFTDPFFI-VETLCIIWFSFELVVRFFACPSKTDFFKNIMNFID 258

Query: 310 IVSVLPFYLTLLAGVALGDQGGKEFGHLGK---VVQVFRLMRIFRVLKLARHSTGLRSLG 366
           IV+++P+++TL  G  + +Q G + G       +++V RL+R+FR+ KL+RHS GL+ LG
Sbjct: 259 IVAIIPYFITL--GTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILG 316

Query: 367 ATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEE-DVGFNTIPACWWWGTVSMTTVGYG 425
            TLK S RE+G+L+ +L +GV +FS   Y AE EE +  F++IP  +WW  VSMTTVGYG
Sbjct: 317 QTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYG 376

Query: 426 DVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQ 467
           D+ PVT+ GK+  S C + G+L +ALP+ +I + F++FY R+
Sbjct: 377 DMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE 418


>gi|4504817 potassium voltage-gated channel, shaker-related
           subfamily, member 4 [Homo sapiens]
          Length = 653

 Score =  232 bits (592), Expect = 6e-61
 Identities = 147/450 (32%), Positives = 232/450 (51%), Gaps = 63/450 (14%)

Query: 38  GPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDE 97
           G  + +R+    E + +NV G+R +   + LA+FP T LG            +    +D 
Sbjct: 164 GGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLG---------DPEKRTQYFDP 214

Query: 98  AAREFYFDRHPGFFLSLLHFYRTG-HLHVLDELCVFAFGQEADYWGLGENALAACCRARY 156
              E++FDR+   F ++L++Y++G  L     +    F +E  ++ LGE AL        
Sbjct: 215 LRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEG 274

Query: 157 LERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYS 216
             R        +ED   P +                          ++++WL  E P  S
Sbjct: 275 FVRE-------EEDRALPEN------------------------EFKKQIWLLFEYPESS 303

Query: 217 LPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAG---------------R 261
            P++  + VS+ V+L SI   C+ +LPE+  R+    V A++AG                
Sbjct: 304 SPARGIAIVSVLVILISIVIFCLETLPEF--RDDRDLVMALSAGGHGGLLNDTSAPHLEN 361

Query: 262 SPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTL- 320
           S   + +DP    +E  CI WFSFE   R    PS   FF + +N+IDIVS+LP+++TL 
Sbjct: 362 SGHTIFNDPFFI-VETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLG 420

Query: 321 --LAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGI 378
             LA    G  G ++      ++++ RL+R+FR+ KL+RHS GL+ LG TL+ S RE+G+
Sbjct: 421 TDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGL 480

Query: 379 LLLYLAVGVSVFSGVAYTAEKEEDVG-FNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLA 437
           L+ +L +GV +FS   Y AE +E    F +IP  +WW  V+MTTVGYGD+ P+TV GK+ 
Sbjct: 481 LIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIV 540

Query: 438 ASGCILGGILVVALPITIIFNKFSHFYRRQ 467
            S C + G+L +ALP+ +I + F++FY R+
Sbjct: 541 GSLCAIAGVLTIALPVPVIVSNFNYFYHRE 570


>gi|88758576 Shaw-related voltage-gated potassium channel protein 4
           isoform c [Homo sapiens]
          Length = 626

 Score =  231 bits (588), Expect = 2e-60
 Identities = 147/453 (32%), Positives = 221/453 (48%), Gaps = 43/453 (9%)

Query: 48  SDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAR------- 100
           + E + +NVGG R +     L   PGTRL  L  A  +   R   D     +        
Sbjct: 34  ASEKIIINVGGTRHETYRSTLRTLPGTRLAWL--ADPDGGGRPETDGGGVGSSGSSGGGG 91

Query: 101 -EFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLER 159
            EF+FDRHPG F  +L++YRTG LH   ++C   F +E  +WG+ E  +  CC   Y + 
Sbjct: 92  CEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQH 151

Query: 160 RLTQPHAWD--EDSDTPSSVDPCPDEISDVQRELARY-------------GAARCGRLRR 204
           R  +  A D  E  D   S     DE  D +RELA               G+  C   + 
Sbjct: 152 RDAE-EALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQP 210

Query: 205 RLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPE 264
           R+W   E+P  S  +++ +  S+  +L SI   C+ +   +        +  V    S  
Sbjct: 211 RMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVH 270

Query: 265 GVRD---DPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLL 321
             R+   +P+L  +E  C+ WF+ E   R++  P T +F  + LN+ID V++LPFYL   
Sbjct: 271 FRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLE-- 328

Query: 322 AGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL 381
             V L     K    +   ++V R +RI R+ KL RH  GLR LG TL+ S  E  +L++
Sbjct: 329 --VGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLII 386

Query: 382 YLAVGVSVFSGVAYTAEK----------EEDVGFNTIPACWWWGTVSMTTVGYGDVVPVT 431
           +LA+GV +F+ + Y AE+           +   F  IP  +WW  V+MTT+GYGD+ P T
Sbjct: 387 FLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKT 446

Query: 432 VAGKLAASGCILGGILVVALPITIIFNKFSHFY 464
            +G L  + C L G+L +A+P+ +I N F  +Y
Sbjct: 447 WSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479


>gi|24497462 Shaw-related voltage-gated potassium channel protein 4
           isoform a [Homo sapiens]
          Length = 635

 Score =  231 bits (588), Expect = 2e-60
 Identities = 147/453 (32%), Positives = 221/453 (48%), Gaps = 43/453 (9%)

Query: 48  SDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAR------- 100
           + E + +NVGG R +     L   PGTRL  L  A  +   R   D     +        
Sbjct: 34  ASEKIIINVGGTRHETYRSTLRTLPGTRLAWL--ADPDGGGRPETDGGGVGSSGSSGGGG 91

Query: 101 -EFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLER 159
            EF+FDRHPG F  +L++YRTG LH   ++C   F +E  +WG+ E  +  CC   Y + 
Sbjct: 92  CEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQH 151

Query: 160 RLTQPHAWD--EDSDTPSSVDPCPDEISDVQRELARY-------------GAARCGRLRR 204
           R  +  A D  E  D   S     DE  D +RELA               G+  C   + 
Sbjct: 152 RDAE-EALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQP 210

Query: 205 RLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPE 264
           R+W   E+P  S  +++ +  S+  +L SI   C+ +   +        +  V    S  
Sbjct: 211 RMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVH 270

Query: 265 GVRD---DPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLL 321
             R+   +P+L  +E  C+ WF+ E   R++  P T +F  + LN+ID V++LPFYL   
Sbjct: 271 FRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLE-- 328

Query: 322 AGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL 381
             V L     K    +   ++V R +RI R+ KL RH  GLR LG TL+ S  E  +L++
Sbjct: 329 --VGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLII 386

Query: 382 YLAVGVSVFSGVAYTAEK----------EEDVGFNTIPACWWWGTVSMTTVGYGDVVPVT 431
           +LA+GV +F+ + Y AE+           +   F  IP  +WW  V+MTT+GYGD+ P T
Sbjct: 387 FLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKT 446

Query: 432 VAGKLAASGCILGGILVVALPITIIFNKFSHFY 464
            +G L  + C L G+L +A+P+ +I N F  +Y
Sbjct: 447 WSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479


>gi|24497464 Shaw-related voltage-gated potassium channel protein 4
           isoform b [Homo sapiens]
          Length = 582

 Score =  231 bits (588), Expect = 2e-60
 Identities = 147/453 (32%), Positives = 221/453 (48%), Gaps = 43/453 (9%)

Query: 48  SDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAR------- 100
           + E + +NVGG R +     L   PGTRL  L  A  +   R   D     +        
Sbjct: 34  ASEKIIINVGGTRHETYRSTLRTLPGTRLAWL--ADPDGGGRPETDGGGVGSSGSSGGGG 91

Query: 101 -EFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLER 159
            EF+FDRHPG F  +L++YRTG LH   ++C   F +E  +WG+ E  +  CC   Y + 
Sbjct: 92  CEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQH 151

Query: 160 RLTQPHAWD--EDSDTPSSVDPCPDEISDVQRELARY-------------GAARCGRLRR 204
           R  +  A D  E  D   S     DE  D +RELA               G+  C   + 
Sbjct: 152 RDAE-EALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQP 210

Query: 205 RLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPE 264
           R+W   E+P  S  +++ +  S+  +L SI   C+ +   +        +  V    S  
Sbjct: 211 RMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVH 270

Query: 265 GVRD---DPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLL 321
             R+   +P+L  +E  C+ WF+ E   R++  P T +F  + LN+ID V++LPFYL   
Sbjct: 271 FRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLE-- 328

Query: 322 AGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL 381
             V L     K    +   ++V R +RI R+ KL RH  GLR LG TL+ S  E  +L++
Sbjct: 329 --VGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLII 386

Query: 382 YLAVGVSVFSGVAYTAEK----------EEDVGFNTIPACWWWGTVSMTTVGYGDVVPVT 431
           +LA+GV +F+ + Y AE+           +   F  IP  +WW  V+MTT+GYGD+ P T
Sbjct: 387 FLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKT 446

Query: 432 VAGKLAASGCILGGILVVALPITIIFNKFSHFY 464
            +G L  + C L G+L +A+P+ +I N F  +Y
Sbjct: 447 WSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479


>gi|4826782 potassium voltage-gated channel, shaker-related
           subfamily, member 2 [Homo sapiens]
          Length = 499

 Score =  229 bits (585), Expect = 4e-60
 Identities = 150/479 (31%), Positives = 244/479 (50%), Gaps = 62/479 (12%)

Query: 50  EALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPG 109
           E + +N+ G+R +   + LA+FP T LG           ++    +D    E++FDR+  
Sbjct: 33  ERVVINISGLRFETQLKTLAQFPETLLG---------DPKKRMRYFDPLRNEYFFDRNRP 83

Query: 110 FFLSLLHFYRTG-HLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWD 168
            F ++L++Y++G  L     + +  F +E  ++ LGE A+           R  + +  +
Sbjct: 84  SFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMF--------REDEGYIKE 135

Query: 169 EDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSIS 228
           E+   P +                          +R++WL  E P  S P+++ + VS+ 
Sbjct: 136 EERPLPEN------------------------EFQRQVWLLFEYPESSGPARIIAIVSVM 171

Query: 229 VVLASIAAMCIHSLPEYQAREA---AAAVAAVAAGRSPEGVRD-----DPVLRRLEYFCI 280
           V+L SI + C+ +LP ++        + V       S  G +      DP    +E  CI
Sbjct: 172 VILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFI-VETLCI 230

Query: 281 AWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTL---LAGVALGDQGGKEFGHL 337
            WFSFE   R    PS   FF + +N+IDIV+++P+++TL   LA      Q G++   L
Sbjct: 231 IWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSL 290

Query: 338 GKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTA 397
             +++V RL+R+FR+ KL+RHS GL+ LG TLK S RE+G+L+ +L +GV +FS   Y A
Sbjct: 291 A-ILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFA 349

Query: 398 EKEE-DVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITII 456
           E +E +  F +IP  +WW  VSMTTVGYGD+VP T+ GK+  S C + G+L +ALP+ +I
Sbjct: 350 EADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVI 409

Query: 457 FNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSIDGVSEASLETSRETSQEGQSADLESQ 515
            + F++FY R+             ++  + S     S   L+ SR  S   +S  +E Q
Sbjct: 410 VSNFNYFYHRE------TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQ 462


>gi|24497460 Shaw-related voltage-gated potassium channel protein 3
           [Homo sapiens]
          Length = 757

 Score =  228 bits (582), Expect = 8e-60
 Identities = 155/483 (32%), Positives = 226/483 (46%), Gaps = 72/483 (14%)

Query: 54  VNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLS 113
           +NVGGVR +     L   PGTRL  L      E A R   DYD  A EF+FDRHPG F  
Sbjct: 92  INVGGVRHETYRSTLRTLPGTRLAGL---TEPEAAARF--DYDPGADEFFFDRHPGVFAY 146

Query: 114 LLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDT 173
           +L++YRTG LH   ++C   F +E  +WG+ E  + ACC   Y + R  +     E  D+
Sbjct: 147 VLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAE-----EALDS 201

Query: 174 PSSVDPC----------------PDE-------ISDVQRELARY--------------GA 196
             + DP                  DE       +     EL R               GA
Sbjct: 202 FEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGA 261

Query: 197 ARCG-----RLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEY-QAREA 250
              G     R + R+W   E+P  S  ++  +  S+  +L SI   C+ +   +      
Sbjct: 262 GGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNK 321

Query: 251 AAAVAAVAAGRSPEGVRD-----DPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPL 305
               A+   G  PE + +     +P L  +E  C+ WF+FE   R+   P    F    L
Sbjct: 322 TVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSL 381

Query: 306 NLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSL 365
           N+ID V++LPFYL     V L     K    +   ++V R +RI R+ KL RH  GLR L
Sbjct: 382 NIIDCVAILPFYLE----VGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVL 437

Query: 366 GATLKHSYREVGILLLYLAVGVSVFSGVAYTAEK-----EEDVG-----FNTIPACWWWG 415
           G TL+ S  E  +L+++LA+GV +F+ + Y AE+     ++ +G     F  IP  +WW 
Sbjct: 438 GHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWA 497

Query: 416 TVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVR 475
            V+MTT+GYGD+ P T +G L  + C L G+L +A+P+ +I N F  +Y    A +   +
Sbjct: 498 VVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPK 557

Query: 476 NSN 478
             N
Sbjct: 558 KKN 560


>gi|27436981 potassium voltage-gated channel, Shal-related
           subfamily, member 1 [Homo sapiens]
          Length = 647

 Score =  226 bits (576), Expect = 4e-59
 Identities = 148/432 (34%), Positives = 218/432 (50%), Gaps = 43/432 (9%)

Query: 39  PDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEA 98
           P  G++  R DE L VNV G R +     L R+P T LG     +SE++       YD  
Sbjct: 29  PAPGVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLG-----SSEKEFF-----YDAD 78

Query: 99  AREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLE 158
           + E++FDR P  F  +L+FYRTG LH   + C+ AF +E  ++GL    +  CC   Y +
Sbjct: 79  SGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRD 138

Query: 159 RRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGR-LRRRLWLTMENPGYSL 217
           R+        ED +   + D                 A   G  LR+RLW   ENP  S 
Sbjct: 139 RKKENAERLAEDEEAEQAGDG---------------PALPAGSSLRQRLWRAFENPHTST 183

Query: 218 PSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEY 277
            + +F  V+   +  S+ A  + ++P           A  ++   P G R       ++ 
Sbjct: 184 AALVFYYVTGFFIAVSVIANVVETIP-------CRGSARRSSREQPCGERFPQAFFCMDT 236

Query: 278 FCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHL 337
            C+  F+ E   RL  APS   F    ++LID+V++LP+Y+ LL  V   D     F  L
Sbjct: 237 ACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLL--VPKNDDVSGAFVTL 294

Query: 338 GKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTA 397
                  R+ R+FR+ K +RHS GLR LG TLK    E+G LL  L + + +F+ V + A
Sbjct: 295 -------RVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYA 347

Query: 398 EKEED-VGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITII 456
           EK  +   F +IPA +W+  V+MTT+GYGD+VP T+AGK+  S C L G+LV+ALP+ +I
Sbjct: 348 EKGTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVI 407

Query: 457 FNKFSHFYRRQK 468
            + FS  Y + +
Sbjct: 408 VSNFSRIYHQNQ 419


>gi|5031819 potassium voltage-gated channel, shaker-related
           subfamily, member 10 [Homo sapiens]
          Length = 511

 Score =  224 bits (570), Expect = 2e-58
 Identities = 137/459 (29%), Positives = 242/459 (52%), Gaps = 51/459 (11%)

Query: 37  PGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYD 96
           PGP+  +     ++ + +N+ G+R +   R L++FP T LG        ++ +R+   +D
Sbjct: 74  PGPEPVVL-NEGNQRVIINIAGLRFETQLRTLSQFPETLLG--------DREKRM-QFFD 123

Query: 97  EAAREFYFDRHPGFFLSLLHFYRTG-HLHVLDELCVFAFGQEADYWGLGENALAACCRAR 155
               E++FDR+   F  +L++Y++G  +     + +  F  E  ++ LG  A+       
Sbjct: 124 SMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMD------ 177

Query: 156 YLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGY 215
               +  +   + +D   P ++ P  D                   + R+ WL  E P  
Sbjct: 178 ----QFREDEGFIKD---PETLLPTND-------------------IHRQFWLLFEYPES 211

Query: 216 SLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSP----EGVRDDPV 271
           S  ++  + VS+ VV+ SI   C+ +LPE++       V       S     + +  DP 
Sbjct: 212 SSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPF 271

Query: 272 LRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGG 331
              +E  CI WF+FE+  R ++ PS  +FF + +N+IDI+S++P++ TL+  +    +  
Sbjct: 272 FM-VESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPS 330

Query: 332 KEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFS 391
            +      ++++ RL+R+FR+ KL+RHS GL+ LG TLK S RE+G+L+ +L +GV +FS
Sbjct: 331 AQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFS 390

Query: 392 GVAYTAEKEE-DVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVA 450
              Y AE +E +  F++IP  +WW  V+MTTVGYGD+ P T  GK+  + C + G+L +A
Sbjct: 391 SAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIA 450

Query: 451 LPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSI 489
           LP+ +I + F++FY R+   E   + +   E E +L+S+
Sbjct: 451 LPVPVIVSNFNYFYHRE--TENEEKQNIPGEIERILNSV 487


>gi|21217561 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2a [Homo sapiens]
          Length = 613

 Score =  223 bits (567), Expect = 4e-58
 Identities = 148/483 (30%), Positives = 225/483 (46%), Gaps = 74/483 (15%)

Query: 48  SDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRL---------------- 91
           ++E + +NVGG R +     L   PGTRL  L  A+SE     L                
Sbjct: 6   NNERVILNVGGTRHETYRSTLKTLPGTRLALL--ASSEPPGDCLTTAGDKLQPSPPPLSP 63

Query: 92  ----------------------------CDDYDEAAREFYFDRHPGFFLSLLHFYRTGHL 123
                                         D+    REF+FDRHPG F  +L++YRTG L
Sbjct: 64  PPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKL 123

Query: 124 HVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSV--DPCP 181
           H   ++C   F +E  +WG+ E  +  CC   Y + R  +     +  +TP  +  DP  
Sbjct: 124 HCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEAL--DIFETPDLIGGDPGD 181

Query: 182 DEISDVQR----ELARYG-----AARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLA 232
           DE    +R    + A  G     + R  RL+ R+W   E+P  S  ++  +  S+  +L 
Sbjct: 182 DEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILV 241

Query: 233 SIAAMCIHSLPEYQ-AREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRL 291
           SI   C+ +   +   +     V    +      +  DP L  +E  C+ WF+FE   R+
Sbjct: 242 SITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRI 301

Query: 292 LLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFR 351
           + +P+   F  + LN+ID V++LPFYL     V L     K    +   ++V R +RI R
Sbjct: 302 VFSPNKLEFIKNLLNIIDFVAILPFYLE----VGLSGLSSKAAKDVLGFLRVVRFVRILR 357

Query: 352 VLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEK----------EE 401
           + KL RH  GLR LG TL+ S  E  +L+++LA+GV +F+ + Y AE+           E
Sbjct: 358 IFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASE 417

Query: 402 DVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFS 461
              F  IP  +WW  V+MTT+GYGD+ P T +G L  + C L G+L +A+P+ +I N F 
Sbjct: 418 HTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFG 477

Query: 462 HFY 464
            +Y
Sbjct: 478 MYY 480


>gi|21217563 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2b [Homo sapiens]
          Length = 638

 Score =  223 bits (567), Expect = 4e-58
 Identities = 148/483 (30%), Positives = 225/483 (46%), Gaps = 74/483 (15%)

Query: 48  SDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRL---------------- 91
           ++E + +NVGG R +     L   PGTRL  L  A+SE     L                
Sbjct: 6   NNERVILNVGGTRHETYRSTLKTLPGTRLALL--ASSEPPGDCLTTAGDKLQPSPPPLSP 63

Query: 92  ----------------------------CDDYDEAAREFYFDRHPGFFLSLLHFYRTGHL 123
                                         D+    REF+FDRHPG F  +L++YRTG L
Sbjct: 64  PPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKL 123

Query: 124 HVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSV--DPCP 181
           H   ++C   F +E  +WG+ E  +  CC   Y + R  +     +  +TP  +  DP  
Sbjct: 124 HCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEAL--DIFETPDLIGGDPGD 181

Query: 182 DEISDVQR----ELARYG-----AARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLA 232
           DE    +R    + A  G     + R  RL+ R+W   E+P  S  ++  +  S+  +L 
Sbjct: 182 DEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILV 241

Query: 233 SIAAMCIHSLPEYQ-AREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRL 291
           SI   C+ +   +   +     V    +      +  DP L  +E  C+ WF+FE   R+
Sbjct: 242 SITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRI 301

Query: 292 LLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFR 351
           + +P+   F  + LN+ID V++LPFYL     V L     K    +   ++V R +RI R
Sbjct: 302 VFSPNKLEFIKNLLNIIDFVAILPFYLE----VGLSGLSSKAAKDVLGFLRVVRFVRILR 357

Query: 352 VLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEK----------EE 401
           + KL RH  GLR LG TL+ S  E  +L+++LA+GV +F+ + Y AE+           E
Sbjct: 358 IFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASE 417

Query: 402 DVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFS 461
              F  IP  +WW  V+MTT+GYGD+ P T +G L  + C L G+L +A+P+ +I N F 
Sbjct: 418 HTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFG 477

Query: 462 HFY 464
            +Y
Sbjct: 478 MYY 480


>gi|24497458 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2c [Homo sapiens]
          Length = 558

 Score =  223 bits (567), Expect = 4e-58
 Identities = 148/483 (30%), Positives = 225/483 (46%), Gaps = 74/483 (15%)

Query: 48  SDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRL---------------- 91
           ++E + +NVGG R +     L   PGTRL  L  A+SE     L                
Sbjct: 6   NNERVILNVGGTRHETYRSTLKTLPGTRLALL--ASSEPPGDCLTTAGDKLQPSPPPLSP 63

Query: 92  ----------------------------CDDYDEAAREFYFDRHPGFFLSLLHFYRTGHL 123
                                         D+    REF+FDRHPG F  +L++YRTG L
Sbjct: 64  PPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKL 123

Query: 124 HVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSV--DPCP 181
           H   ++C   F +E  +WG+ E  +  CC   Y + R  +     +  +TP  +  DP  
Sbjct: 124 HCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEAL--DIFETPDLIGGDPGD 181

Query: 182 DEISDVQR----ELARYG-----AARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLA 232
           DE    +R    + A  G     + R  RL+ R+W   E+P  S  ++  +  S+  +L 
Sbjct: 182 DEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILV 241

Query: 233 SIAAMCIHSLPEYQ-AREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRL 291
           SI   C+ +   +   +     V    +      +  DP L  +E  C+ WF+FE   R+
Sbjct: 242 SITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRI 301

Query: 292 LLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFR 351
           + +P+   F  + LN+ID V++LPFYL     V L     K    +   ++V R +RI R
Sbjct: 302 VFSPNKLEFIKNLLNIIDFVAILPFYLE----VGLSGLSSKAAKDVLGFLRVVRFVRILR 357

Query: 352 VLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEK----------EE 401
           + KL RH  GLR LG TL+ S  E  +L+++LA+GV +F+ + Y AE+           E
Sbjct: 358 IFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASE 417

Query: 402 DVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFS 461
              F  IP  +WW  V+MTT+GYGD+ P T +G L  + C L G+L +A+P+ +I N F 
Sbjct: 418 HTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFG 477

Query: 462 HFY 464
            +Y
Sbjct: 478 MYY 480


>gi|25952087 potassium voltage-gated channel, shaker-related
           subfamily, member 5 [Homo sapiens]
          Length = 613

 Score =  222 bits (565), Expect = 7e-58
 Identities = 143/448 (31%), Positives = 233/448 (52%), Gaps = 71/448 (15%)

Query: 50  EALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPG 109
           + + +N+ G+R +     LA+FP T LG        + A+RL   +D    E++FDR+  
Sbjct: 120 QRVHINISGLRFETQLGTLAQFPNTLLG--------DPAKRL-RYFDPLRNEYFFDRNRP 170

Query: 110 FFLSLLHFYRTG-HLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWD 168
            F  +L++Y++G  L     + +  F  E  ++ LG+ A+      R+ E         D
Sbjct: 171 SFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAME-----RFRE---------D 216

Query: 169 EDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSIS 228
           E              I + ++ L R         +R++WL  E P  S  ++  + VS+ 
Sbjct: 217 EGF------------IKEEEKPLPR------NEFQRQVWLIFEYPESSGSARAIAIVSVL 258

Query: 229 VVLASIAAMCIHSLPEYQAREA------------AAAVAAVAAG--RSPEGVRDDPVLRR 274
           V+L SI   C+ +LPE++                A A  A  +G    P G    P+L R
Sbjct: 259 VILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPR 318

Query: 275 --------LEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVAL 326
                   +E  C+ WF+FE+  R    PS   F  + +N+ID+V++ P+++TL   +A 
Sbjct: 319 TLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAE 378

Query: 327 GDQGGKEFGHLGK------VVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILL 380
              GG   G  G+      +++V RL+R+FR+ KL+RHS GL+ LG TL+ S RE+G+L+
Sbjct: 379 QQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLI 438

Query: 381 LYLAVGVSVFSGVAYTAEKE-EDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAAS 439
            +L +GV +FS   Y AE + +   F++IP  +WW  V+MTTVGYGD+ P+TV GK+  S
Sbjct: 439 FFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGS 498

Query: 440 GCILGGILVVALPITIIFNKFSHFYRRQ 467
            C + G+L +ALP+ +I + F++FY R+
Sbjct: 499 LCAIAGVLTIALPVPVIVSNFNYFYHRE 526


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,910,326
Number of Sequences: 37866
Number of extensions: 879201
Number of successful extensions: 2923
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 117
Number of HSP's successfully gapped in prelim test: 54
Number of HSP's that attempted gapping in prelim test: 2440
Number of HSP's gapped (non-prelim): 375
length of query: 526
length of database: 18,247,518
effective HSP length: 107
effective length of query: 419
effective length of database: 14,195,856
effective search space: 5948063664
effective search space used: 5948063664
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.