Search of human proteins with 6005737

Search of human proteins with 6005737

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide
8 [Homo sapiens]
         (520 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...  1075   0.0  
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...   891   0.0  
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...   865   0.0  
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...   865   0.0  
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...   848   0.0  
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide...   832   0.0  
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide...   660   0.0  
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide...   415   e-116
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide...   409   e-114
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide...   405   e-113
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ...   391   e-109
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ...   387   e-107
gi|30023836 cytochrome P450 4Z1 [Homo sapiens]                        384   e-106
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   288   6e-78
gi|239757171 PREDICTED: similar to cytochrome P450, family 4, su...   244   2e-64
gi|239751683 PREDICTED: similar to cytochrome P450, family 4, su...   244   2e-64
gi|239746187 PREDICTED: similar to cytochrome P450, family 4, su...   244   2e-64
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   156   4e-38
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   156   5e-38
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   155   6e-38
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   154   1e-37
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   152   9e-37
gi|5729796 cytochrome P450, family 46 [Homo sapiens]                  136   4e-32
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H...   121   2e-27
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H...   121   2e-27
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ...   117   3e-26
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...   110   3e-24
gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide ...   105   1e-22
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ...   102   6e-22
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   100   4e-21

>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score = 1075 bits (2780), Expect = 0.0
 Identities = 520/520 (100%), Positives = 520/520 (100%)

Query: 1   MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF 60
           MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF
Sbjct: 1   MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF 60

Query: 61  LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK 120
           LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK
Sbjct: 61  LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK 120

Query: 121 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR 180
           DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR
Sbjct: 121 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR 180

Query: 181 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF 240
           LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF
Sbjct: 181 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF 240

Query: 241 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID 300
           RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID
Sbjct: 241 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID 300

Query: 301 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360
           VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
Sbjct: 301 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360

Query: 361 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC 420
           LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC
Sbjct: 361 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC 420

Query: 421 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV 480
           NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV
Sbjct: 421 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV 480

Query: 481 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG 520
           VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG
Sbjct: 481 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG 520


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score =  891 bits (2303), Expect = 0.0
 Identities = 422/519 (81%), Positives = 468/519 (90%)

Query: 1   MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF 60
           MS LSLSWLGL PVAASPWLLLL+VGASWLLA +LAWTYAFY N RRLRCFPQP ++NWF
Sbjct: 1   MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWF 60

Query: 61  LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK 120
            GH G+V PTEEG+RVLTQLVATYPQGF  W+GPI+P+++LCHPDI+RSVIN S AI  K
Sbjct: 61  WGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPK 120

Query: 121 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR 180
           D  FY  L+PWLGDGLLLS GDKW  HRR+LTPAFHFNILKPY+KIF++S NIMHAKWQ 
Sbjct: 121 DKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL 180

Query: 181 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF 240
           LA EGS CLD+FEHISLMTLDSLQKC+FSFDS+CQEKPSEYI AI+ELSALV KR+++  
Sbjct: 181 LASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEIL 240

Query: 241 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID 300
            + DFLY+LTP G+RF RACRLVHDFTDAVIQERRRTL SQGVDDFLQAKAKSKTLDFID
Sbjct: 241 LHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID 300

Query: 301 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360
           VLLLS+D++GK+LSDEDIRAEADTFMF GHDTTASGLSWVLY+LA+HPEYQERCRQEVQE
Sbjct: 301 VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE 360

Query: 361 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC 420
           LLKDREPKEIEWDDLA LPFLTMC+KESLRLHPP+P  +R  TQD+VLPD RVIPKG +C
Sbjct: 361 LLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIIC 420

Query: 421 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV 480
            I++F  HHNP+VWPDPEVYDPFRFDPEN ++RSP+AFIPFSAGPRNCIGQ FAMAEMKV
Sbjct: 421 LISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKV 480

Query: 481 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPL 519
           VLALTLLRFR+LPDH EPRR PE+VLRAE GLWLRVEPL
Sbjct: 481 VLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPL 519


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  865 bits (2236), Expect = 0.0
 Identities = 412/520 (79%), Positives = 454/520 (87%)

Query: 1   MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF 60
           M  LSLSWLGL PVAASPWLLLL+VG SWLLAR+LAWTY FY N RRL+CFPQP KQNWF
Sbjct: 1   MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWF 60

Query: 61  LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK 120
            GH GLVTPTEEG++ LTQLV TYPQGF  WLGP  P++ LCHPDI+R + + S A+  K
Sbjct: 61  WGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPK 120

Query: 121 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR 180
           D++FY  LKPWLGDGLLLS GDKW  HRR+LTPAFHFNILKPY+KIF+KS NIMH KWQR
Sbjct: 121 DMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQR 180

Query: 181 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF 240
           LA EGS  LD+FEHISLMTLDSLQKC+FSF+SNCQEKPSEYI AI+ELSA V KRN Q  
Sbjct: 181 LASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQIL 240

Query: 241 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID 300
            + DFLY+LTP G+RF RAC LVHDFTDAVIQERR TL +QG+DDFL+ KAKSKTLDFID
Sbjct: 241 LHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFID 300

Query: 301 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360
           VLLLS+D++GKELSDEDIRAEADTFMF GHDTTASGLSWVLY+LA+HPEYQE+CRQEVQE
Sbjct: 301 VLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQE 360

Query: 361 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC 420
           LLKDREP EIEWDDLAQLPFLTMC+KESLRLHPP+P  +R CTQD VLPD RVIPKG VC
Sbjct: 361 LLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVC 420

Query: 421 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV 480
            INI  IH+NP+VWPDPEVYDPFRFD EN ++RSP+AFIPFSAGPRNCIGQ FAMAEMKV
Sbjct: 421 LINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV 480

Query: 481 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG 520
           VLALTLL FRILP H EPRR PE++LRAE GLWLRVEPLG
Sbjct: 481 VLALTLLHFRILPTHTEPRRKPELILRAEGGLWLRVEPLG 520


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  865 bits (2236), Expect = 0.0
 Identities = 412/520 (79%), Positives = 454/520 (87%)

Query: 1   MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF 60
           M  LSLSWLGL PVAASPWLLLL+VG SWLLAR+LAWTY FY N RRL+CFPQP KQNWF
Sbjct: 1   MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWF 60

Query: 61  LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK 120
            GH GLVTPTEEG++ LTQLV TYPQGF  WLGP  P++ LCHPDI+R + + S A+  K
Sbjct: 61  WGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPK 120

Query: 121 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR 180
           D++FY  LKPWLGDGLLLS GDKW  HRR+LTPAFHFNILKPY+KIF+KS NIMH KWQR
Sbjct: 121 DMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQR 180

Query: 181 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF 240
           LA EGS  LD+FEHISLMTLDSLQKC+FSF+SNCQEKPSEYI AI+ELSA V KRN Q  
Sbjct: 181 LASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQIL 240

Query: 241 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID 300
            + DFLY+LTP G+RF RAC LVHDFTDAVIQERR TL +QG+DDFL+ KAKSKTLDFID
Sbjct: 241 LHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFID 300

Query: 301 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360
           VLLLS+D++GKELSDEDIRAEADTFMF GHDTTASGLSWVLY+LA+HPEYQE+CRQEVQE
Sbjct: 301 VLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQE 360

Query: 361 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC 420
           LLKDREP EIEWDDLAQLPFLTMC+KESLRLHPP+P  +R CTQD VLPD RVIPKG VC
Sbjct: 361 LLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVC 420

Query: 421 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV 480
            INI  IH+NP+VWPDPEVYDPFRFD EN ++RSP+AFIPFSAGPRNCIGQ FAMAEMKV
Sbjct: 421 LINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV 480

Query: 481 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG 520
           VLALTLL FRILP H EPRR PE++LRAE GLWLRVEPLG
Sbjct: 481 VLALTLLHFRILPTHTEPRRKPELILRAEGGLWLRVEPLG 520


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score =  848 bits (2191), Expect = 0.0
 Identities = 406/519 (78%), Positives = 451/519 (86%)

Query: 1   MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF 60
           MSLLSL WLGLRPVA SPWLLLL+V  SWLLARILAWTYAFY+N RRL+CFPQP K+NWF
Sbjct: 1   MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF 60

Query: 61  LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK 120
            GHLGL+TPTEEGL+  TQ+ ATY QGF  WLGPI P I LCHPD +RS+ N S AI  K
Sbjct: 61  WGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK 120

Query: 121 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR 180
           D +F + LKPWLG+G+LLS GDKW  HRR+LTPAFHFNILK YI IF+KSANIM  KWQ 
Sbjct: 121 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH 180

Query: 181 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF 240
           LA EGS+ LD+FEHISLMTLDSLQKCIFSFDS+CQE+PSEYI  I+ELSALV KR+    
Sbjct: 181 LASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL 240

Query: 241 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID 300
           ++ DFLY+L+  GRRFHRACRLVHDFTDAVI+ERRRTL +QG+DDF + KAKSKTLDFID
Sbjct: 241 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID 300

Query: 301 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360
           VLLLS+D++GK LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
Sbjct: 301 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360

Query: 361 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC 420
           LLKDR+PKEIEWDDLAQLPFLTMC+KESLRLHPP P  +R CTQD+VLPD RVIPKG  C
Sbjct: 361 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC 420

Query: 421 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV 480
            I+I  +HHNP+VWPDPEVYDPFRFDPEN++ RSP+AFIPFSAGPRNCIGQ FAMAEMKV
Sbjct: 421 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV 480

Query: 481 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPL 519
           VLAL LL FR LPDH EPRR  E+++RAE GLWLRVEPL
Sbjct: 481 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPL 519


>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
           [Homo sapiens]
          Length = 520

 Score =  832 bits (2150), Expect = 0.0
 Identities = 401/519 (77%), Positives = 445/519 (85%)

Query: 1   MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF 60
           M  LSLS LGL P+AASPWLLLL+VGASWLLARILAWTY FY N  RLRCFPQP K+NWF
Sbjct: 1   MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWF 60

Query: 61  LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK 120
           LGHLGL+  +EEGL     L  T+      W+GP   I+ + HP  ++ V+    AI  K
Sbjct: 61  LGHLGLIHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPK 120

Query: 121 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR 180
           D VFY  LKPWLGDGLLLS G+KW  HRR+LTPAFHFNILKPY+KIF++S NIMHAKWQ 
Sbjct: 121 DKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL 180

Query: 181 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF 240
           LA EGS  LD+FEHISLMTLDSLQKC+FSFDS+CQEKPSEYI AI+ELSALV KR+ Q  
Sbjct: 181 LASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQIL 240

Query: 241 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID 300
            Y DFLY+LTP G+RF RACRLVHDFTDAVIQERRRTL SQGVDDFLQAKAKSKTLDFID
Sbjct: 241 LYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID 300

Query: 301 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360
           VLLLS+D++GK+LSDEDIRAEADTFMF GHDTTASGLSWVLY+LA+HPEYQERCRQEVQE
Sbjct: 301 VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE 360

Query: 361 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC 420
           LLKDREPKEIEWDDLAQLPFLTMC+KESLRLHPP+P  +R CTQD+VLPD RVIPKG +C
Sbjct: 361 LLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIIC 420

Query: 421 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV 480
            I++F  HHNP+VWPDPEVYDPFRFDP+N ++RSP+AFIPFSAGPRNCIGQ FAMAEMKV
Sbjct: 421 LISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV 480

Query: 481 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPL 519
           VL LTLLRFR+LPDH EPRR PE+VLRAE GLWLRVEPL
Sbjct: 481 VLGLTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPL 519


>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
           [Homo sapiens]
          Length = 531

 Score =  660 bits (1703), Expect = 0.0
 Identities = 314/520 (60%), Positives = 404/520 (77%), Gaps = 2/520 (0%)

Query: 1   MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF 60
           + LL L     R  A S  LL L+     LL R L    +FY   RRLRCFPQP ++NW 
Sbjct: 9   LHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWL 68

Query: 61  LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK 120
           LGHLG+  P E GL+   +++       + W+GP+ P++ L HPD ++ ++  S AI  K
Sbjct: 69  LGHLGMYLPNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPK 128

Query: 121 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR 180
           D +FY  LKPWLGDGLLLS GDKW  HRRLLTPAFHF+ILKPY+KIF++SA+IMHAKW+ 
Sbjct: 129 DDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRH 188

Query: 181 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF 240
           LA   +  LD+FEHISLMTLDSLQKC+FS++SNCQEK S+YI+AI+ELSAL V+R  +  
Sbjct: 189 LAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLH 248

Query: 241 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID 300
            Y DF+Y+ +  GRRF +AC +VH FT  VIQERRR L  QG + +L+AK + KTLDFID
Sbjct: 249 HYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAK-QGKTLDFID 307

Query: 301 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360
           VLLL+ D++GKELSDEDIRAEADTFMF GHDTT+SG+SW+L+NLA++PEYQE+CR+E+QE
Sbjct: 308 VLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQE 367

Query: 361 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC 420
           ++K RE +E+EWDDL QLPF TMC+KESLR +PP+   +R CT+D+ LPD R+IPKG +C
Sbjct: 368 VMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIIC 427

Query: 421 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV 480
            ++I+  HHNP+VWPD +VY+P+RFDP+N Q+RSP+A++PFSAGPRNCIGQ FAMAE++V
Sbjct: 428 LVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRV 487

Query: 481 VLALTLLRFRILPDH-REPRRTPEIVLRAEDGLWLRVEPL 519
           V+ALTLLRFR+  D  R+ RR PE++LR E+GLWL+VEPL
Sbjct: 488 VVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPL 527


>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
           [Homo sapiens]
          Length = 519

 Score =  415 bits (1066), Expect = e-116
 Identities = 220/477 (46%), Positives = 303/477 (63%), Gaps = 16/477 (3%)

Query: 46  RRLRCFPQPRKQNWFLGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPD 105
           + L+ FP P   +W  GH+  +   +E L+ + + V T+P     WL      + L  PD
Sbjct: 46  KALQQFPCP-PSHWLFGHIQELQQDQE-LQRIQKWVETFPSACPHWLWGGKVRVQLYDPD 103

Query: 106 IVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIK 165
            ++ ++  SD    K    Y+ L PW+G GLLL  G  W  HRR+LTPAFH++ILKPY+ 
Sbjct: 104 YMKVILGRSDP---KSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVG 160

Query: 166 IFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQ--EKPSEYIT 223
           + + S  +M  KW+ L  + S  L+VF+H+SLMTLD++ KC FS   + Q       YI 
Sbjct: 161 LMADSVRVMLDKWEELLGQDSP-LEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQ 219

Query: 224 AIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGV 283
           AI +L+ LV  R    F   D +Y LT  GR  HRAC+L H  TD VIQ R+  L  +G 
Sbjct: 220 AISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGE 279

Query: 284 DDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYN 343
              L+   + + LDF+D+LLL++ +NG  LSD+D+RAE DTFMF GHDTTASG+SW+LY 
Sbjct: 280 ---LEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYA 336

Query: 344 LARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCT 403
           LA HP++QERCR+E+  LL D     I W+ L Q+P+ TMC+KE+LRL+PP+P   R  +
Sbjct: 337 LATHPKHQERCREEIHSLLGD--GASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELS 394

Query: 404 QDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSA 463
             V  PD R +PKG +  ++I+ +HHNP VWP+PEV+DPFRF P +AQ     AF+PFS 
Sbjct: 395 TPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSH--AFLPFSG 452

Query: 464 GPRNCIGQKFAMAEMKVVLALTLLRFRILPD-HREPRRTPEIVLRAEDGLWLRVEPL 519
           G RNCIG++FAM E+KV  ALTLLRF +LPD  R P     +VL++++G+ LR+  L
Sbjct: 453 GSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRLRRL 509


>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform b [Homo sapiens]
          Length = 511

 Score =  409 bits (1051), Expect = e-114
 Identities = 223/521 (42%), Positives = 321/521 (61%), Gaps = 20/521 (3%)

Query: 2   SLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFL 61
           S LSLS+  L   A+    L+LV+G   L+  +L          + +  FP P   +W  
Sbjct: 4   SFLSLSFSSLGLWASG---LILVLGFLKLIHLLLRRQTL----AKAMDKFPGP-PTHWLF 55

Query: 62  GHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKD 121
           GH   +  T   L  +      +P     W G     +N+  PD  ++V +  D    K 
Sbjct: 56  GHALEIQETGS-LDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDP---KA 111

Query: 122 IVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRL 181
              Y     W+G GLL+  G KW  HR+LLTP FH+++LKPY+ +F++S  IM  KW+  
Sbjct: 112 PDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEK 171

Query: 182 AMEGSTCLDVFEHISLMTLDSLQKCIFSF-DSNCQEKPSEYITAIMELSALVVKRNNQFF 240
           A EG +  D+F  +  M L++L KC F   D+    + S Y  A+ +L+ L+ +R   F 
Sbjct: 172 AREGKS-FDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQ 230

Query: 241 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID 300
            + DF+Y+LTP GRRF RAC++ HD TD VI+ER+  L  + V   +Q +   + LDF+D
Sbjct: 231 YHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNR---RHLDFLD 287

Query: 301 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE 360
           +LL + D++  +LSD D+RAE DTFMF GHDTT SG+SW LY +A +PE+Q RCR+EV+E
Sbjct: 288 ILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVRE 347

Query: 361 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC 420
           +L D++    +WDDL ++ +LTMC+KES RL+PP+P   R  ++ V   D R +P G++ 
Sbjct: 348 ILGDQD--FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLI 405

Query: 421 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV 480
           +++I+A+H N +VWPDPEV+D  RF  ENA KR P AF+PFSAGPRNCIGQ+FAM+EMKV
Sbjct: 406 SMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKV 465

Query: 481 VLALTLLRFRI-LPDHREPRRTPEIVLRAEDGLWLRVEPLG 520
           V A+ LLRF   L   R P + P++VLR+++G  L ++PLG
Sbjct: 466 VTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLG 506


>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform a [Homo sapiens]
          Length = 512

 Score =  405 bits (1042), Expect = e-113
 Identities = 222/522 (42%), Positives = 319/522 (61%), Gaps = 21/522 (4%)

Query: 2   SLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFL 61
           S LSLS+  L   A+    L+LV+G   L+  +L          + +  FP P   +W  
Sbjct: 4   SFLSLSFSSLGLWASG---LILVLGFLKLIHLLLRRQTL----AKAMDKFPGP-PTHWLF 55

Query: 62  GHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKD 121
           GH   +  T   L  +      +P     W G     +N+  PD  ++V +  D    K 
Sbjct: 56  GHALEIQETGS-LDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDP---KA 111

Query: 122 IVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRL 181
              Y     W+G GLL+  G KW  HR+LLTP FH+++LKPY+ +F++S  IM  KW+  
Sbjct: 112 PDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEK 171

Query: 182 AMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNC--QEKPSEYITAIMELSALVVKRNNQF 239
           A EG +  D+F  +  M L++L KC F          + S Y  A+ +L+ L+ +R   F
Sbjct: 172 AREGKS-FDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSF 230

Query: 240 FRYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFI 299
             + DF+Y+LTP GRRF RAC++ HD TD VI+ER+  L  + V   +Q +   + LDF+
Sbjct: 231 QYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNR---RHLDFL 287

Query: 300 DVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQ 359
           D+LL + D++  +LSD D+RAE DTFMF GHDTT SG+SW LY +A +PE+Q RCR+EV+
Sbjct: 288 DILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVR 347

Query: 360 ELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNV 419
           E+L D++    +WDDL ++ +LTMC+KES RL+PP+P   R  ++ V   D R +P G++
Sbjct: 348 EILGDQD--FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSL 405

Query: 420 CNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMK 479
            +++I+A+H N +VWPDPEV+D  RF  ENA KR P AF+PFSAGPRNCIGQ+FAM+EMK
Sbjct: 406 ISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMK 465

Query: 480 VVLALTLLRFRI-LPDHREPRRTPEIVLRAEDGLWLRVEPLG 520
           VV A+ LLRF   L   R P + P++VLR+++G  L ++PLG
Sbjct: 466 VVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLG 507


>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
           [Homo sapiens]
          Length = 519

 Score =  391 bits (1004), Expect = e-109
 Identities = 222/503 (44%), Positives = 306/503 (60%), Gaps = 24/503 (4%)

Query: 20  LLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFLGHLGLVTPTEEGLRVLTQ 79
           LLLL+  A   L R   W        + L+ FP P   +W  GH+      +E L+ + +
Sbjct: 28  LLLLIKAAQLYLHR--QWLL------KALQQFPCP-PSHWLFGHIQEFQHDQE-LQRIQE 77

Query: 80  LVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLS 139
            V T+P     W+      + L  PD ++ ++  SD    K    YK L P +G GLLL 
Sbjct: 78  RVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDP---KSHGSYKFLAPRIGYGLLLL 134

Query: 140 VGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMT 199
            G  W  HRR+LTPAFH +ILKPY+ + + S  +M  KW+ L  + S  L+VF+H+SLMT
Sbjct: 135 NGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSP-LEVFQHVSLMT 193

Query: 200 LDSLQKCIFSFDSNCQ--EKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFH 257
           LD++ K  FS   + Q       YI AI +L++LV       F   D +Y LT  GR  H
Sbjct: 194 LDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTH 253

Query: 258 RACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDED 317
           RAC+L H  TD VIQ R+  L  +G    L+   + + LDF+D+LLL++ +NG  LSD+D
Sbjct: 254 RACQLAHQHTDQVIQLRKAQLQKEGE---LEKIKRKRHLDFLDILLLAKMENGSILSDKD 310

Query: 318 IRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQ 377
           +RAE DTFMF GHDTTASG+SW+LY LA HP++QERCR+E+  LL D     I W+ L Q
Sbjct: 311 LRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGD--GASITWNHLDQ 368

Query: 378 LPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDP 437
           +P+ TMC+KE+LRL+PP+P   R  +  V  PD R +PKG +  ++I+ +HHNP VWP+ 
Sbjct: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNL 428

Query: 438 EVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPD-HR 496
           EV+DP RF P +AQ     AF+PFS G RNCIG++FAM ++KV  ALTLLRF +LPD  R
Sbjct: 429 EVFDPSRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTR 486

Query: 497 EPRRTPEIVLRAEDGLWLRVEPL 519
            P     +VL++++G+ LR+  L
Sbjct: 487 IPIPMARLVLKSKNGIHLRLRRL 509


>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
           [Homo sapiens]
          Length = 509

 Score =  387 bits (995), Expect = e-107
 Identities = 200/519 (38%), Positives = 308/519 (59%), Gaps = 16/519 (3%)

Query: 4   LSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFLGH 63
           +  SWL  R   A P+ L  V   +  L + +          R LR FP P   +WFLGH
Sbjct: 1   MEFSWLETR--WARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAP-PTHWFLGH 57

Query: 64  LGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIV 123
              +   ++ +  L +++  YP+ F  W+GP      +  PD  +++++ +D    K   
Sbjct: 58  QKFIQ--DDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDP---KSQY 112

Query: 124 FYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAM 183
             K   P LG GL    G KW  HRRLLTP FHFNILK YI++ + S  +M  KW+++  
Sbjct: 113 LQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICS 172

Query: 184 EGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSE--YITAIMELSALVVKRNNQFFR 241
              T ++V+EHI+ M+LD + KC FS ++NCQ   +   Y  AI ELS ++  R      
Sbjct: 173 TQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLY 232

Query: 242 YKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDV 301
           + D ++ L+P G RF +  R+++ +TD +IQER+++L +    D      K K  DF+D+
Sbjct: 233 HSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQD---NTPKRKYQDFLDI 289

Query: 302 LLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQEL 361
           +L ++D++G   SD D+ +E  TF+  GHDT A+ +SW+LY LA +PE+QERCR+EV+ +
Sbjct: 290 VLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGI 349

Query: 362 LKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCN 421
           L D     I WD L ++ + TMC+KE+ RL P +P+ +R  ++ +  PD   +P G    
Sbjct: 350 LGDGS--SITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVV 407

Query: 422 INIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVV 481
           ++I+ +HHNP+VW +P+V+DP RF  EN+ +R P A++PFSAG RNCIGQ+FAM E+KV 
Sbjct: 408 LSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVT 467

Query: 482 LALTLLRFRILPDHREPRRTP-EIVLRAEDGLWLRVEPL 519
           +AL LL FR+ PD   P   P   +L+ ++G++L ++ L
Sbjct: 468 IALILLHFRVTPDPTRPLTFPNHFILKPKNGMYLHLKKL 506


>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
          Length = 505

 Score =  384 bits (986), Expect = e-106
 Identities = 204/509 (40%), Positives = 312/509 (61%), Gaps = 18/509 (3%)

Query: 7   SWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFLGHLGL 66
           SWL  + + A P+LLL+++  S LL +++          R L  FP P   +WF GH   
Sbjct: 4   SWL--QELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAP-PAHWFYGHKEF 60

Query: 67  VTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYK 126
             P +E   V  +L+  YP     W+GP T   ++  PD  + ++   D    K  V +K
Sbjct: 61  Y-PVKE-FEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDP---KSAVSHK 115

Query: 127 TLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGS 186
            L+ W+G GL+   G KW+ HR+++ P F+ +ILK +I + S+S  +M  KW+    + S
Sbjct: 116 ILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNS 175

Query: 187 TCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPS--EYITAIMELSALVVKRNNQFFRYKD 244
             L++F+H+SLMTLDS+ KC FS   + Q   +   Y+ A+  LS +  +R N F  + D
Sbjct: 176 R-LELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHND 234

Query: 245 FLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLL 304
            ++  +  G+ F +  + +H FT+ VIQ+R+ +L     D   Q   + +  DF+D+LL 
Sbjct: 235 LVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLK----DKLKQDTTQKRRWDFLDILLS 290

Query: 305 SEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKD 364
           ++ +N K+ S+ D++AE  TFMF GHDTT+S +SW+LY LA++PE+Q+RCR E++ELL D
Sbjct: 291 AKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGD 350

Query: 365 REPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINI 424
                I W+ L+Q+P+ TMC+KE LRL+ P+   +R   + +  PD R +P G    INI
Sbjct: 351 GS--SITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINI 408

Query: 425 FAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLAL 484
           +A+HHNP  W DP+V++P RF  EN++K  P AFIPFSAG RNCIGQ FA+ E KV +AL
Sbjct: 409 WALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVAL 468

Query: 485 TLLRFRILPDH-REPRRTPEIVLRAEDGL 512
           TLLRF++ PDH R P+   ++VL++++G+
Sbjct: 469 TLLRFKLAPDHSRPPQPVRQVVLKSKNGI 497


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  288 bits (738), Expect = 6e-78
 Identities = 183/527 (34%), Positives = 289/527 (54%), Gaps = 30/527 (5%)

Query: 8   WLGLRPVAASPW---LLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFLGHL 64
           WLGL       W     L + GAS +L+ +L    ++    +++R  P   +    +GH 
Sbjct: 5   WLGLVWQKLLLWGAASALSLAGASLVLS-LLQRVASYARKWQQMRPIPTVARAYPLVGHA 63

Query: 65  GLVTPTEEGLRVLTQLVATYPQGFVR------WLGPITPIINLCHPDIVRSVINTSDAIT 118
            L+ P     R   Q +  Y + +        W+GP+ P++ L + + V  ++ +S  I 
Sbjct: 64  LLMKPDG---REFFQQIIEYTEEYRHMPLLKLWVGPV-PMVALYNAENVEVILTSSKQID 119

Query: 119 DKDIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKW 178
              +  YK L+PWLG GLL S G+KWR  R++LTP FHF IL+ ++ I ++ ANI+  K 
Sbjct: 120 KSSM--YKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKL 177

Query: 179 QR-LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKP-SEYITAIMELSALVVKRN 236
           ++ +  E   C   F +I+L  LD + +     +   Q    SEY+ A+  +S ++ +R 
Sbjct: 178 EKHINQEAFNC---FFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRI 234

Query: 237 NQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGV---DDFLQAKAKS 293
              + + D  Y +   G    ++ +++H FT++VI ER   + +      D    A +K+
Sbjct: 235 KMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKN 294

Query: 294 KTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQER 353
           K   F+D+LL   D  G  LS EDIR E DTFMF GHDTTA+ ++W LY L  +PE Q++
Sbjct: 295 KRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKK 354

Query: 354 CRQEVQELL-KDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSR 412
              E+ ++  K   P  +E  DL +L +L   +KE+LRL P +P FAR  ++D  +   R
Sbjct: 355 VDHELDDVFGKSDRPATVE--DLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYR 412

Query: 413 VIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQK 472
           V+ KG    I  +A+H +P  +P+PE + P RF PENAQ R P A++PFSAGPRNCIGQK
Sbjct: 413 VL-KGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQK 471

Query: 473 FAMAEMKVVLALTLLRFRILPDHR--EPRRTPEIVLRAEDGLWLRVE 517
           FA+ E K +L+  L  F I  + +  E     +++LR  +G+W++++
Sbjct: 472 FAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLK 518


>gi|239757171 PREDICTED: similar to cytochrome P450, family 4,
           subfamily F, polypeptide 2 [Homo sapiens]
          Length = 190

 Score =  244 bits (622), Expect = 2e-64
 Identities = 115/157 (73%), Positives = 133/157 (84%)

Query: 150 LLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFS 209
           +L PAFHFNILKPY+KIF +S NIMHAKW  L +E + CLD+FEH++LMTLDSLQKC+FS
Sbjct: 1   MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60

Query: 210 FDSNCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDA 269
           FDS CQEKPSEYI +++ELS+LV KRN Q   + DFLY+LT  GR FHRACRL HDF DA
Sbjct: 61  FDSQCQEKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFADA 120

Query: 270 VIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSE 306
            IQE+R TL SQGVDDFLQAKAKSKTLDFIDVLL+S+
Sbjct: 121 AIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLLISK 157


>gi|239751683 PREDICTED: similar to cytochrome P450, family 4,
           subfamily F, polypeptide 2 [Homo sapiens]
          Length = 190

 Score =  244 bits (622), Expect = 2e-64
 Identities = 115/157 (73%), Positives = 133/157 (84%)

Query: 150 LLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFS 209
           +L PAFHFNILKPY+KIF +S NIMHAKW  L +E + CLD+FEH++LMTLDSLQKC+FS
Sbjct: 1   MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60

Query: 210 FDSNCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDA 269
           FDS CQEKPSEYI +++ELS+LV KRN Q   + DFLY+LT  GR FHRACRL HDF DA
Sbjct: 61  FDSQCQEKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFADA 120

Query: 270 VIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSE 306
            IQE+R TL SQGVDDFLQAKAKSKTLDFIDVLL+S+
Sbjct: 121 AIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLLISK 157


>gi|239746187 PREDICTED: similar to cytochrome P450, family 4,
           subfamily F, polypeptide 2 [Homo sapiens]
          Length = 190

 Score =  244 bits (622), Expect = 2e-64
 Identities = 115/157 (73%), Positives = 133/157 (84%)

Query: 150 LLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFS 209
           +L PAFHFNILKPY+KIF +S NIMHAKW  L +E + CLD+FEH++LMTLDSLQKC+FS
Sbjct: 1   MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60

Query: 210 FDSNCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDA 269
           FDS CQEKPSEYI +++ELS+LV KRN Q   + DFLY+LT  GR FHRACRL HDF DA
Sbjct: 61  FDSQCQEKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFADA 120

Query: 270 VIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSE 306
            IQE+R TL SQGVDDFLQAKAKSKTLDFIDVLL+S+
Sbjct: 121 AIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLLISK 157


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  156 bits (395), Expect = 4e-38
 Identities = 116/411 (28%), Positives = 200/411 (48%), Gaps = 37/411 (9%)

Query: 97  PIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPW-----LGDGLLLSVGDKWRHHRRLL 151
           P++ +  PD++++V+        +    +   +P+     + + + ++  ++W+  R LL
Sbjct: 80  PMLAITDPDMIKTVL------VKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLL 133

Query: 152 TPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGS--TCLDVFEHISLMTLDSLQKCIFS 209
           +P F    LK  + I ++  +++    +R A  G   T   VF   S+  + S    + S
Sbjct: 134 SPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGV-S 192

Query: 210 FDS--NCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRAC---RLVH 264
            DS  N Q+   E    ++  + L     + F        FLTP     +      +++ 
Sbjct: 193 IDSLNNPQDPFVENTKKLLRFNPL-----DPFVLSIKVFPFLTPILEALNITVFPRKVIS 247

Query: 265 DFTDAV--IQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEA 322
             T +V  I+E R   T +   DFLQ          ID     + +  K LSD ++ A++
Sbjct: 248 FLTKSVKQIKEGRLKETQKHRVDFLQL--------MIDSQNSKDSETHKALSDLELMAQS 299

Query: 323 DTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLT 382
             F+F G++TT+S LS+++Y LA HP+ Q++ ++E+  +L ++ P    +D + QL +L 
Sbjct: 300 IIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPT--YDTVLQLEYLD 357

Query: 383 MCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDP 442
           M + E+LRL P      R C +DV + +   IPKG V  I  + +HH+P  W +PE + P
Sbjct: 358 MVVNETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLP 416

Query: 443 FRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILP 493
            RF  +N     P  + PF +GPRNCIG +FA+  MK+ L   L  F   P
Sbjct: 417 ERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKP 467


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  156 bits (394), Expect = 5e-38
 Identities = 106/407 (26%), Positives = 194/407 (47%), Gaps = 29/407 (7%)

Query: 97  PIINLCHPDIVRSVINTSDAITDKDIVFYKTLK----PWLGDGLLLSVGDKWRHHRRLLT 152
           P++ +  PD++++V+     + +   VF   +      +L   L  +  ++W+  R LL+
Sbjct: 80  PMLVIMDPDMIKTVL-----VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLS 134

Query: 153 PAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDS 212
           PAF     K  + I S+  +++  +  R   E S  +++ +     T+D +   +F  + 
Sbjct: 135 PAFTSVKFKEMVPIISQCGDML-VRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNL 193

Query: 213 NCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFH------RACRLVHDF 266
           +    P +     M+   L +   + F        FLTP     +           + + 
Sbjct: 194 DSLNNPQDPFLKNMK-KLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNS 252

Query: 267 TDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFM 326
            + + + R +      VD F Q          ID     E K+ K LSD ++ A++   +
Sbjct: 253 IERMKESRLKDKQKHRVDFFQQ---------MIDSQNSKETKSHKALSDLELVAQSIIII 303

Query: 327 FGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLK 386
           F  +DTT++ L +++Y LA HP+ Q++ ++E+  +L ++ P  + +D L Q+ +L M + 
Sbjct: 304 FAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP--VTYDALVQMEYLDMVVN 361

Query: 387 ESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFD 446
           E+LRL P +    R C +D+ + +   IPKG    + I+A+HH+P  W +PE + P RF 
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS 420

Query: 447 PENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILP 493
            +N        +IPF AGPRNCIG +FA+  +K+ +   L  F   P
Sbjct: 421 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKP 467


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  155 bits (393), Expect = 6e-38
 Identities = 135/502 (26%), Positives = 238/502 (47%), Gaps = 64/502 (12%)

Query: 14  VAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRC-FPQPRKQNWFLGHLGLVTPTEE 72
           +A   WLLL V       + +L + Y    +G   R   P P      L  LG V    +
Sbjct: 7   LAVETWLLLAV-------SLVLLYLYGTRTHGLFKRLGIPGPTP----LPLLGNVLSYRQ 55

Query: 73  GL-RVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVI--NTSDAITDKDIVFYKTLK 129
           GL +  T+    Y + +  + G + P++ +  PD++R+V+        T++     ++L 
Sbjct: 56  GLWKFDTECYKKYGKMWGTYEGQL-PVLAITDPDVIRTVLVKECYSVFTNR-----RSLG 109

Query: 130 P--WLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGS- 186
           P  ++   + L+  ++W+  R LL+P F    LK    I ++  +++    +R A +G  
Sbjct: 110 PVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKP 169

Query: 187 -TCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRYKDF 245
            T  D+F   S+   D +    F  + +    P +     +E +   +K     F + D 
Sbjct: 170 VTLKDIFGAYSM---DVITGTSFGVNIDSLNNPQD---PFVESTKKFLK-----FGFLDP 218

Query: 246 LY-------FLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKT--- 295
           L+       FLTP          +      ++  +      S+ V+   +++   K    
Sbjct: 219 LFLSIILFPFLTP----------VFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHR 268

Query: 296 LDFIDVLLLS----EDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQ 351
           LDF+ +++ S    E ++ K LSD ++ A++  F+F G++TT+S LS+ LY LA HP+ Q
Sbjct: 269 LDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQ 328

Query: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDS 411
           ++ ++E+  +L ++ P    +D + Q+ +L M + E+LRL P      R C +DV + + 
Sbjct: 329 QKLQKEIDAVLPNKAPP--TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI-NG 385

Query: 412 RVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQ 471
             IPKG++  I  +A+HH+P  W +PE + P RF  +      P  + PF  GPRNCIG 
Sbjct: 386 VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-KKKDSIDPYIYTPFGTGPRNCIGM 444

Query: 472 KFAMAEMKVVLALTLLRFRILP 493
           +FA+  MK+ L   L  F   P
Sbjct: 445 RFALMNMKLALIRVLQNFSFKP 466


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  154 bits (390), Expect = 1e-37
 Identities = 114/410 (27%), Positives = 201/410 (49%), Gaps = 35/410 (8%)

Query: 97  PIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSV-----GDKWRHHRRLL 151
           P++ +  PD++++V+        +    +   +P+   G + S       ++W+  R LL
Sbjct: 80  PVLAITDPDMIKTVL------VKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLL 133

Query: 152 TPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGS--TCLDVFEHISLMTLDSLQKCIFS 209
           +P F    LK  + I ++  +++    +R A  G   T  DVF   S+  + S    + +
Sbjct: 134 SPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGV-N 192

Query: 210 FDS--NCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFT 267
            DS  N Q+   E    ++    L     + FF       FL P     +  C    + T
Sbjct: 193 IDSLNNPQDPFVENTKKLLRFDFL-----DPFFLSITVFPFLIPILEVLN-ICVFPREVT 246

Query: 268 DAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLS----EDKNGKELSDEDIRAEAD 323
           + + +  +R   S+  D       +   +DF+ +++ S    E ++ K LSD ++ A++ 
Sbjct: 247 NFLRKSVKRMKESRLED------TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300

Query: 324 TFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTM 383
            F+F G++TT+S LS+++Y LA HP+ Q++ ++E+  +L ++ P    +D + Q+ +L M
Sbjct: 301 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT--YDTVLQMEYLDM 358

Query: 384 CLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPF 443
            + E+LRL P      R C +DV + +   IPKG V  I  +A+H +P  W +PE + P 
Sbjct: 359 VVNETLRLFPIAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPE 417

Query: 444 RFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILP 493
           RF  +N     P  + PF +GPRNCIG +FA+  MK+ L   L  F   P
Sbjct: 418 RFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  152 bits (383), Expect = 9e-37
 Identities = 106/408 (25%), Positives = 194/408 (47%), Gaps = 30/408 (7%)

Query: 97  PIINLCHPDIVRSVINTSDAITDKDIVFYKTLK----PWLGDGLLLSVGDKWRHHRRLLT 152
           P++ +  PD++++V+     + +   VF   +      +L   L  +  ++W+  R LL+
Sbjct: 80  PMLVIMDPDMIKTVL-----VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLS 134

Query: 153 PAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDS 212
           PAF     K  + I S+  +++  +  R   E S  +++ +     T+D +   +F  + 
Sbjct: 135 PAFTSVKFKEMVPIISQCGDML-VRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNL 193

Query: 213 NCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFH------RACRLVHDF 266
           +    P +     M+   L +   + F        FLTP     +           + + 
Sbjct: 194 DSLNNPQDPFLKNMK-KLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNS 252

Query: 267 TDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFM 326
            + + + R +      VD F Q          ID     E K+ K LSD ++ A++   +
Sbjct: 253 IERMKESRLKDKQKHRVDFFQQ---------MIDSQNSKETKSHKALSDLELVAQSIIII 303

Query: 327 FGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLK 386
           F  +DTT++ L +++Y LA HP+ Q++ ++E+  +L ++ P  + +D L Q+ +L M + 
Sbjct: 304 FAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP--VTYDALVQMEYLDMVVN 361

Query: 387 ESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDP-FRF 445
           E+LRL P +    R C +D+ + +   IPKG    + I+A+HH+P  W +PE + P  RF
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRF 420

Query: 446 DPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILP 493
             +N        +IPF AGPRNCIG +FA+  +K+ +   L  F   P
Sbjct: 421 SKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKP 468


>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
          Length = 500

 Score =  136 bits (343), Expect = 4e-32
 Identities = 138/507 (27%), Positives = 233/507 (45%), Gaps = 68/507 (13%)

Query: 17  SPWLLLLVVGASWLLARILAWTYAFYHNGR-RLRCFPQPRKQNWFLGHLGLVTPTEE-GL 74
           SP LLLL  G++ LLA  L  T  F H  R R    P P + ++ LGHL      +E G 
Sbjct: 2   SPGLLLL--GSAVLLAFGLCCT--FVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGG 57

Query: 75  RVLTQLVATYPQGFVRWLGPITPII--NLCHPDIVRSVINTSDAIT--------DKDIVF 124
           RVL  +       F+ W     P++  N+ H   V  ++ + +++         +KD   
Sbjct: 58  RVLQDV-------FLDWAKKYGPVVRVNVFHKTSV--IVTSPESVKKFLMSTKYNKDSKM 108

Query: 125 YKTLKPWLGD-----GLLLSVG-DKWRHHRRLLTPAFHFNILKPYIKIFSKSAN----IM 174
           Y+ L+   G+     GL+     ++W   RR++  AF  + L   ++ F++ A     I+
Sbjct: 109 YRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEIL 168

Query: 175 HAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNC---QEKPSEYITAIMELSAL 231
            AK      +G T + + + ++   +D L K  F  +++     +KP      +M L  +
Sbjct: 169 EAK-----ADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLM-LEGI 222

Query: 232 VVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKA 291
              RN        FL       R    + R +       +Q RR  L           + 
Sbjct: 223 TASRNT----LAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALK----------RG 268

Query: 292 KSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQ 351
           +    D +  +L +E+  G +  DE +     TF   GH+T+A+ L++ +  L+R PE  
Sbjct: 269 EEVPADILTQILKAEE--GAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIV 325

Query: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDS 411
            R + EV E++  +  + ++++DL +L +L+  LKESLRL+PP     R   ++ ++   
Sbjct: 326 ARLQAEVDEVIGSK--RYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGV 383

Query: 412 RVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQ 471
           RV P       + + +    + + DP  ++P RF P   + R    + PFS G R+CIGQ
Sbjct: 384 RV-PGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQ 440

Query: 472 KFAMAEMKVVLA--LTLLRFRILPDHR 496
           +FA  E+KVV+A  L  L FR++P  R
Sbjct: 441 QFAQMEVKVVMAKLLQRLEFRLVPGQR 467


>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  121 bits (303), Expect = 2e-27
 Identities = 107/426 (25%), Positives = 185/426 (43%), Gaps = 56/426 (13%)

Query: 132 LGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDV 191
           + D +L     +W   R  L  AF    L   + + S++ +++ A  +R A  G    D+
Sbjct: 121 VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDA-FDI 179

Query: 192 FEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRY--------- 242
                  T D +    F    +  + P +            VK   +FF +         
Sbjct: 180 QRCYCNYTTDVVASVAFGTPVDSWQAPEDPF----------VKHCKRFFEFCIPRPILVL 229

Query: 243 -KDFLYFLTPCGRR------------FHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQA 289
              F   + P  R             F++  R V    D    E RR    Q V D   +
Sbjct: 230 LLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHS 289

Query: 290 KAKSKTLDFIDVLLLSEDKNG---------------KELSDEDIRAEADTFMFGGHDTTA 334
            +     DF D++       G               + L+ ++I  +A  F+  G++   
Sbjct: 290 ASPMGVQDF-DIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT 348

Query: 335 SGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQ-LPFLTMCLKESLRLHP 393
           + LS+  Y LA +P+ QE+  +EV ++ K++     E+  L + LP+L M + E+LR++P
Sbjct: 349 NTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAP-EFCSLEEGLPYLDMVIAETLRMYP 406

Query: 394 PIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKR 453
           P   F R   QD  +   R IP G V  + + A+HH+P  WP PE ++P RF  E  Q+ 
Sbjct: 407 PAFRFTREAAQDCEVLGQR-IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQH 465

Query: 454 SPMAFIPFSAGPRNCIGQKFAMAEMKVVL--ALTLLRFRILPDHREP-RRTPEIVLRAED 510
            P  ++PF AGPR+C+G +  + E+K+ L   L   RF+  P+ + P +   +  L  ++
Sbjct: 466 RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKN 525

Query: 511 GLWLRV 516
           G+++++
Sbjct: 526 GVYIKI 531


>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  121 bits (303), Expect = 2e-27
 Identities = 107/426 (25%), Positives = 185/426 (43%), Gaps = 56/426 (13%)

Query: 132 LGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDV 191
           + D +L     +W   R  L  AF    L   + + S++ +++ A  +R A  G    D+
Sbjct: 121 VADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDA-FDI 179

Query: 192 FEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRY--------- 242
                  T D +    F    +  + P +            VK   +FF +         
Sbjct: 180 QRCYCNYTTDVVASVAFGTPVDSWQAPEDPF----------VKHCKRFFEFCIPRPILVL 229

Query: 243 -KDFLYFLTPCGRR------------FHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQA 289
              F   + P  R             F++  R V    D    E RR    Q V D   +
Sbjct: 230 LLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHS 289

Query: 290 KAKSKTLDFIDVLLLSEDKNG---------------KELSDEDIRAEADTFMFGGHDTTA 334
            +     DF D++       G               + L+ ++I  +A  F+  G++   
Sbjct: 290 ASPMGVQDF-DIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIIT 348

Query: 335 SGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQ-LPFLTMCLKESLRLHP 393
           + LS+  Y LA +P+ QE+  +EV ++ K++     E+  L + LP+L M + E+LR++P
Sbjct: 349 NTLSFATYLLATNPDCQEKLLREV-DVFKEKHMAP-EFCSLEEGLPYLDMVIAETLRMYP 406

Query: 394 PIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKR 453
           P   F R   QD  +   R IP G V  + + A+HH+P  WP PE ++P RF  E  Q+ 
Sbjct: 407 PAFRFTREAAQDCEVLGQR-IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQH 465

Query: 454 SPMAFIPFSAGPRNCIGQKFAMAEMKVVL--ALTLLRFRILPDHREP-RRTPEIVLRAED 510
            P  ++PF AGPR+C+G +  + E+K+ L   L   RF+  P+ + P +   +  L  ++
Sbjct: 466 RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKN 525

Query: 511 GLWLRV 516
           G+++++
Sbjct: 526 GVYIKI 531


>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 3 [Homo sapiens]
          Length = 420

 Score =  117 bits (293), Expect = 3e-26
 Identities = 87/358 (24%), Positives = 168/358 (46%), Gaps = 29/358 (8%)

Query: 97  PIINLCHPDIVRSVINTSDAITDKDIVFYKTLK----PWLGDGLLLSVGDKWRHHRRLLT 152
           P++ +  PD++++V+     + +   VF   +      +L   L  +  ++W+  R LL+
Sbjct: 80  PMLVIMDPDMIKTVL-----VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLS 134

Query: 153 PAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDS 212
           PAF     K  + I S+  +++  +  R   E S  +++ +     T+D +   +F  + 
Sbjct: 135 PAFTSVKFKEMVPIISQCGDML-VRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNL 193

Query: 213 NCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFH------RACRLVHDF 266
           +    P +     M+   L +   + F        FLTP     +           + + 
Sbjct: 194 DSLNNPQDPFLKNMK-KLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNS 252

Query: 267 TDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFM 326
            + + + R +      VD F Q          ID     E K+ K LSD ++ A++   +
Sbjct: 253 IERMKESRLKDKQKHRVDFFQQ---------MIDSQNSKETKSHKALSDLELVAQSIIII 303

Query: 327 FGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLK 386
           F  +DTT++ L +++Y LA HP+ Q++ ++E+  +L ++ P  + +D L Q+ +L M + 
Sbjct: 304 FAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP--VTYDALVQMEYLDMVVN 361

Query: 387 ESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFR 444
           E+LRL P +    R C +D+ + +   IPKG    + I+A+HH+P  W +PE + P R
Sbjct: 362 ETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score =  110 bits (275), Expect = 3e-24
 Identities = 99/418 (23%), Positives = 188/418 (44%), Gaps = 50/418 (11%)

Query: 99  INLCHPDIVRSVINTSDAITDKDIVFYKTLKPWL--------GDGLLLSVGDKWRHHRRL 150
           ++L  P ++ ++  T  A   +       +KPW         G GLL+  G+ W+  R  
Sbjct: 107 VHLGSPCLLEALYRTESAYPQR-----LEIKPWKAYRDYRKEGYGLLILEGEDWQRVRS- 160

Query: 151 LTPAFHFNILKP--YIKIFSKSANIMH---AKWQRLAMEGSTCLDVFEHISLMTLDSLQK 205
              AF   ++KP   +K+ +K   ++     +   L  E     D++  ++  + +S+  
Sbjct: 161 ---AFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICL 217

Query: 206 CIFSFDSNCQEKPS--EYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLV 263
            ++       +K +  E +  IM +  ++    + F R       +TP         ++ 
Sbjct: 218 VLYEKRFGLLQKNAGDEAVNFIMAIKTMM----STFGRM-----MVTPVELHKSLNTKVW 268

Query: 264 HDFT---DAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRA 320
            D T   D + +  +       +D+ L+  ++  + DF     L +  +   LS +++ A
Sbjct: 269 QDHTLAWDTIFKSVKAC-----IDNRLEKYSQQPSADF-----LCDIYHQNRLSKKELYA 318

Query: 321 EADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPF 380
                     +TTA+ L W+LYNL+R+P+ Q++  +E+Q +L + +    E  DL  +P+
Sbjct: 319 AVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAE--DLRNMPY 376

Query: 381 LTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVY 440
           L  CLKES+RL P +P   R   +  VL +   +PKG V  +N   +  +   + D   +
Sbjct: 377 LKACLKESMRLTPSVPFTTRTLDKATVLGE-YALPKGTVLMLNTQVLGSSEDNFEDSSQF 435

Query: 441 DPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREP 498
            P R+  E  +K +P A +PF  G R CIG++ A  ++ + L   + ++ I     EP
Sbjct: 436 RPERWLQEK-EKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEP 492


>gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide 1
           precursor [Homo sapiens]
          Length = 531

 Score =  105 bits (261), Expect = 1e-22
 Identities = 92/383 (24%), Positives = 173/383 (45%), Gaps = 40/383 (10%)

Query: 146 HHRRLLTPAFHFNILKP-----YIKIFSKSANIMHAKWQRLAME---GSTCLDVFEHISL 197
           HH   L  A +  +LKP     Y   F++  +    +  +L  E   G+   D+ +    
Sbjct: 152 HHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYY 211

Query: 198 MTLDSLQKCIFSFDSNCQEK--PSEYITAIMELSALVVKRNNQFFRYKDFLYFLT----P 251
             L+++   +F     C ++  P + +T +  +  +      Q   Y  FL   T    P
Sbjct: 212 FALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMF-----QNSLYATFLPKWTRPVLP 266

Query: 252 CGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKS--KTLDFIDVLLLSEDKN 309
             +R+      +  F   +I E+   + +Q     LQA      +   ++  LL S    
Sbjct: 267 FWKRYLDGWNAIFSFGKKLIDEKLEDMEAQ-----LQAAGPDGIQVSGYLHFLLASG--- 318

Query: 310 GKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKE 369
             +LS  +        +  G DTT++ L+W LY+L++ PE QE   +EV  ++   +  +
Sbjct: 319 --QLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQ 376

Query: 370 IEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHH 429
            +  D A +P L   LKE+LRL+P +PT +R   +++ + D  + PK        + +  
Sbjct: 377 HK--DFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEV-DGFLFPKNTQFVFCHYVVSR 433

Query: 430 NPSVWPDPEVYDPFRF----DPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALT 485
           +P+ + +PE + P R+     P   + + P   +PF  G R C+G++ A  EM+++LA  
Sbjct: 434 DPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARL 493

Query: 486 LLRFRIL--PDHREPRRTPEIVL 506
           + +++++  P+  E +    IVL
Sbjct: 494 IQKYKVVLAPETGELKSVARIVL 516


>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 508

 Score =  102 bits (255), Expect = 6e-22
 Identities = 59/184 (32%), Positives = 94/184 (51%), Gaps = 2/184 (1%)

Query: 311 KELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEI 370
           +EL  + I       +  G DT ++ LSW LY L+RHPE Q     E+   L        
Sbjct: 300 EELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYP 359

Query: 371 EWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHN 430
               L+QLP L   +KE LRL+P +P  +R   +D+ + D  +IPK  +  +  +A   +
Sbjct: 360 SATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGD-YIIPKNTLVTLCHYATSRD 418

Query: 431 PSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFR 490
           P+ +P+P  + P R+  E      P A +PF  G R+C+G++ A  E+++ LA  L  F 
Sbjct: 419 PAQFPEPNSFRPARWLGEGPTPH-PFASLPFGFGKRSCMGRRLAELELQMALAQILTHFE 477

Query: 491 ILPD 494
           + P+
Sbjct: 478 VQPE 481


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  100 bits (248), Expect = 4e-21
 Identities = 117/522 (22%), Positives = 214/522 (40%), Gaps = 51/522 (9%)

Query: 10  GLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFLGHLGLVTP 69
           G   +  + +LLL  +G   LL +            RR   FP       F+G++  +  
Sbjct: 10  GAAALGGALFLLLFALGVRQLLKQ------------RRPMGFPPGPPGLPFIGNIYSLAA 57

Query: 70  TEEGLRV-LTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIV--FYK 126
           + E   V + +    Y + F   LG I+ ++   +  +   +++ S+   D+  +  F K
Sbjct: 58  SSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMK 117

Query: 127 TLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGS 186
             K  +G  L    G  W  HRRL   +F +     Y +   +S  +   K+   A+E  
Sbjct: 118 MTK--MGGLLNSRYGRGWVDHRRLAVNSFRYF---GYGQKSFESKILEETKFFNDAIETY 172

Query: 187 TCLDV-FEHISLMTLDSLQKCI-----FSFDSNCQEKPSEYITAIMELSALVVKRNNQFF 240
                 F+ +    + ++   I     F+++    +   E  +  +EL+A     +   F
Sbjct: 173 KGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAA-----SASVF 227

Query: 241 RYKDFLYF-LTPCGR--RFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLD 297
            Y  F +  + P G+  +  R   +V+DF   +I++       Q    F+ A        
Sbjct: 228 LYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDA-------- 279

Query: 298 FIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQE 357
           ++D +   ++      S E++       +  G +TT + L W +  +A +P  Q + ++E
Sbjct: 280 YLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKE 339

Query: 358 VQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKG 417
           + +L+     K   WDD  ++P+    L E LR    +P      T +  +     IPKG
Sbjct: 340 I-DLIMGPNGKP-SWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKG 397

Query: 418 NVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAE 477
                N++++H +   W DPEV+ P RF   +       A +PFS G R+C+G+  A  E
Sbjct: 398 TTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARME 457

Query: 478 MKVVLALTLLRFRI-LPDHREPRRTPEIVLRAEDGLWLRVEP 518
           M +     L RF +  P    P   P +      G+ L+ +P
Sbjct: 458 MFLFFTALLQRFHLHFPHELVPDLKPRL------GMTLQPQP 493


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.140    0.450 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,045,053
Number of Sequences: 37866
Number of extensions: 969423
Number of successful extensions: 2921
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 2668
Number of HSP's gapped (non-prelim): 109
length of query: 520
length of database: 18,247,518
effective HSP length: 107
effective length of query: 413
effective length of database: 14,195,856
effective search space: 5862888528
effective search space used: 5862888528
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.