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Search of human proteins with 59853352
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|59853352 myosin VIIA and Rab interacting protein [Homo
sapiens]
(859 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|59853352 myosin VIIA and Rab interacting protein [Homo sapiens] 1712 0.0
gi|109826351 melanophilin isoform 2 [Homo sapiens] 171 2e-42
gi|13129108 melanophilin isoform 1 [Homo sapiens] 171 2e-42
gi|33636771 myelin-associated oligodendrocyte basic protein [Hom... 81 4e-15
gi|110227631 synaptotagmin-like 3 [Homo sapiens] 80 1e-14
gi|193804862 synaptotagmin-like 4 [Homo sapiens] 72 2e-12
gi|193804860 synaptotagmin-like 4 [Homo sapiens] 72 2e-12
gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens] 68 3e-11
gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens] 68 3e-11
gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens] 68 3e-11
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 63 1e-09
gi|154354983 regulating synaptic membrane exocytosis 2 isoform a... 57 1e-07
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 54 6e-07
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 53 1e-06
gi|5902064 rabphilin 3A-like (without C2 domains) [Homo sapiens] 52 2e-06
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 52 2e-06
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens] 50 1e-05
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens] 50 1e-05
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 49 2e-05
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 49 3e-05
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 49 3e-05
gi|55741849 WD repeat domain 22 [Homo sapiens] 48 4e-05
gi|239754474 PREDICTED: similar to mucin [Homo sapiens] 47 8e-05
gi|239743051 PREDICTED: hypothetical protein XP_002342747 [Homo ... 47 8e-05
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 46 1e-04
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 46 1e-04
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 46 1e-04
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 46 1e-04
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 46 1e-04
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 46 1e-04
>gi|59853352 myosin VIIA and Rab interacting protein [Homo sapiens]
Length = 859
Score = 1712 bits (4435), Expect = 0.0
Identities = 859/859 (100%), Positives = 859/859 (100%)
Query: 1 MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFV 60
MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFV
Sbjct: 1 MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFV 60
Query: 61 EHCCMRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQSLEW 120
EHCCMRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQSLEW
Sbjct: 61 EHCCMRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQSLEW 120
Query: 121 FYNNVKSRFKRFGSAKVLKNLYRKHRLESGACFDILGGSLFESNLENEGSISGSDSTFYR 180
FYNNVKSRFKRFGSAKVLKNLYRKHRLESGACFDILGGSLFESNLENEGSISGSDSTFYR
Sbjct: 121 FYNNVKSRFKRFGSAKVLKNLYRKHRLESGACFDILGGSLFESNLENEGSISGSDSTFYR 180
Query: 181 QSEGHSVMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATTI 240
QSEGHSVMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATTI
Sbjct: 181 QSEGHSVMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATTI 240
Query: 241 LQKIIRKQKSKSEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSAFSIT 300
LQKIIRKQKSKSEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSAFSIT
Sbjct: 241 LQKIIRKQKSKSEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSAFSIT 300
Query: 301 GEEALKTPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVALKD 360
GEEALKTPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVALKD
Sbjct: 301 GEEALKTPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVALKD 360
Query: 361 GAPPPTRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRN 420
GAPPPTRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRN
Sbjct: 361 GAPPPTRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRN 420
Query: 421 PQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAP 480
PQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAP
Sbjct: 421 PQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAP 480
Query: 481 RNPAAEKMRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSKE 540
RNPAAEKMRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSKE
Sbjct: 481 RNPAAEKMRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSKE 540
Query: 541 PSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETS 600
PSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETS
Sbjct: 541 PSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETS 600
Query: 601 SGEDQESEPKTESENQKESLSSEDNSQSVQEELKKKFSAVSLCNISTEVLKVINATEELI 660
SGEDQESEPKTESENQKESLSSEDNSQSVQEELKKKFSAVSLCNISTEVLKVINATEELI
Sbjct: 601 SGEDQESEPKTESENQKESLSSEDNSQSVQEELKKKFSAVSLCNISTEVLKVINATEELI 660
Query: 661 AGSTGPWESPQVPPDRQKGMFPRGTDQVRLDEQLTSLEENVYLAAGTVYGLETQLTELED 720
AGSTGPWESPQVPPDRQKGMFPRGTDQVRLDEQLTSLEENVYLAAGTVYGLETQLTELED
Sbjct: 661 AGSTGPWESPQVPPDRQKGMFPRGTDQVRLDEQLTSLEENVYLAAGTVYGLETQLTELED 720
Query: 721 AARCIHSGTDETHLADLEDQVATAAAQVHHAELQISDIESRISALTIAGLNIAPCVRFTR 780
AARCIHSGTDETHLADLEDQVATAAAQVHHAELQISDIESRISALTIAGLNIAPCVRFTR
Sbjct: 721 AARCIHSGTDETHLADLEDQVATAAAQVHHAELQISDIESRISALTIAGLNIAPCVRFTR 780
Query: 781 RRDQKQRTQVQTIDTSRQQRRKLPAPPVKAEKIETSSVTTIKTFNHNFILQGSSTNRTKE 840
RRDQKQRTQVQTIDTSRQQRRKLPAPPVKAEKIETSSVTTIKTFNHNFILQGSSTNRTKE
Sbjct: 781 RRDQKQRTQVQTIDTSRQQRRKLPAPPVKAEKIETSSVTTIKTFNHNFILQGSSTNRTKE 840
Query: 841 RKGTTKDLMEPALESAVMY 859
RKGTTKDLMEPALESAVMY
Sbjct: 841 RKGTTKDLMEPALESAVMY 859
>gi|109826351 melanophilin isoform 2 [Homo sapiens]
Length = 572
Score = 171 bits (434), Expect = 2e-42
Identities = 110/291 (37%), Positives = 159/291 (54%), Gaps = 16/291 (5%)
Query: 1 MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFV 60
MG+KLDLS LTD+E +HVL+VVQRDF+LR+KEEERL LK K+ +E SK +LS
Sbjct: 1 MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN 60
Query: 61 EHCCMRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQSLEW 120
E C RC P+ LVN+KRQC +C CKSC E+ W+C C AR+++ SLEW
Sbjct: 61 ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW 120
Query: 121 FYNNVKSRFKRFGSAKVLKNLYRKHRLESGACFDILGGSLF-ESNLENEGSISGSDSTFY 179
+Y +VK+RFKRFGSAKV+++L+ RL+ GA +++ +S+ +E GS++
Sbjct: 121 YYEHVKARFKRFGSAKVIRSLH--GRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQ 178
Query: 180 RQSEGHSVMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATT 239
Q G L+V E + ++ + + L EA RD + LT+E +
Sbjct: 179 AQPFGSKKKRLLSVH-DFDFEGDSDDSTQPQGHSLHLSSVPEA---RDSPQSLTDESCSE 234
Query: 240 ILQKIIRKQKSKSEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAAL 290
+ K+E E + G C + ++ TS SP + A A L
Sbjct: 235 ------KAAPHKAEGLEEADTG---ASGCHSHPEEQPTSISPSRHGALAEL 276
Score = 53.1 bits (126), Expect = 1e-06
Identities = 85/389 (21%), Positives = 150/389 (38%), Gaps = 66/389 (16%)
Query: 483 PAAEKMRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSKEPS 542
P + L + +PQ T +S + APH + A P ++P+
Sbjct: 207 PQGHSLHLSSVPEARDSPQSL---TDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPT 263
Query: 543 SPSAQ----LRDL----DTHQVS----DDLSETDISNEARDPQTLTDT-TEEKRRNRLYE 589
S S L +L +H+++ L I NE Q L D T ++ R +
Sbjct: 264 SISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHV 323
Query: 590 LAMKMSEKETSSGEDQESEPKTESENQKESLSSEDNSQSVQEELKKKFSAVSLCNISTEV 649
+A S++ + SE+Q + +E L++K ++
Sbjct: 324 MASHHSKRRG----------RASSESQGLGAGVRTEADVEEEALRRKLEELTS------- 366
Query: 650 LKVINATEELIAGSTGPWESPQVPPDRQKGMFPRGTDQVRLDEQLTSLEENVYLAAGTVY 709
N +++ + + + P+R K + P L + V AA
Sbjct: 367 ----NVSDQETSSEEEEAKDEKAEPNRDKSVGP-----------LPQADPEVGTAAHQTN 411
Query: 710 GLETQLTELEDAARCIHSGTDETHLADLEDQVATAAAQVHHAELQISDIESRISALTIAG 769
E + D + ++ T + L++LED+VA A++V AE ++SDIESRI+AL AG
Sbjct: 412 RQEKSPQDPGDPVQ--YNRTTDEELSELEDRVAVTASEVQQAESEVSDIESRIAALRAAG 469
Query: 770 LNIAPCVRFTRRRDQK-----------QRTQVQTIDTSRQQRRKLPAPPVKAEKIETSSV 818
L + P + R+ + +R + D S + + + P + K S
Sbjct: 470 LTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPS-SEAKAMAVPYLLRRKFSNSLK 528
Query: 819 TTIK---TFNHNFILQGSSTNRT-KERKG 843
+ K +F+ + +GS T R RKG
Sbjct: 529 SQGKDDDSFDRKSVYRGSLTQRNPNARKG 557
>gi|13129108 melanophilin isoform 1 [Homo sapiens]
Length = 600
Score = 171 bits (434), Expect = 2e-42
Identities = 110/291 (37%), Positives = 159/291 (54%), Gaps = 16/291 (5%)
Query: 1 MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFV 60
MG+KLDLS LTD+E +HVL+VVQRDF+LR+KEEERL LK K+ +E SK +LS
Sbjct: 1 MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN 60
Query: 61 EHCCMRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQSLEW 120
E C RC P+ LVN+KRQC +C CKSC E+ W+C C AR+++ SLEW
Sbjct: 61 ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW 120
Query: 121 FYNNVKSRFKRFGSAKVLKNLYRKHRLESGACFDILGGSLF-ESNLENEGSISGSDSTFY 179
+Y +VK+RFKRFGSAKV+++L+ RL+ GA +++ +S+ +E GS++
Sbjct: 121 YYEHVKARFKRFGSAKVIRSLH--GRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQ 178
Query: 180 RQSEGHSVMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATT 239
Q G L+V E + ++ + + L EA RD + LT+E +
Sbjct: 179 AQPFGSKKKRLLSVH-DFDFEGDSDDSTQPQGHSLHLSSVPEA---RDSPQSLTDESCSE 234
Query: 240 ILQKIIRKQKSKSEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAAL 290
+ K+E E + G C + ++ TS SP + A A L
Sbjct: 235 ------KAAPHKAEGLEEADTG---ASGCHSHPEEQPTSISPSRHGALAEL 276
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/133 (30%), Positives = 66/133 (49%), Gaps = 16/133 (12%)
Query: 726 HSGTDETHLADLEDQVATAAAQVHHAELQISDIESRISALTIAGLNIAPCVRFTRRRDQK 785
++ T + L++LED+VA A++V AE ++SDIESRI+AL AGL + P + R+ +
Sbjct: 454 YNRTTDEELSELEDRVAVTASEVQQAESEVSDIESRIAALRAAGLTVKPSGKPRRKSNLP 513
Query: 786 -----------QRTQVQTIDTSRQQRRKLPAPPVKAEKIETSSVTTIK---TFNHNFILQ 831
+R + D S + + + P + K S + K +F+ + +
Sbjct: 514 IFLPRVAGKLGKRPEDPNADPS-SEAKAMAVPYLLRRKFSNSLKSQGKDDDSFDRKSVYR 572
Query: 832 GSSTNRT-KERKG 843
GS T R RKG
Sbjct: 573 GSLTQRNPNARKG 585
>gi|33636771 myelin-associated oligodendrocyte basic protein [Homo
sapiens]
Length = 81
Score = 81.3 bits (199), Expect = 4e-15
Identities = 37/76 (48%), Positives = 53/76 (69%), Gaps = 4/76 (5%)
Query: 39 LKQKLDEEGSKCSILSKHQQFVEHCCMRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKH 98
+ QK +EG + LSK+Q++ EH + CC PFTFL N+K++ D K+++CKS C YQK
Sbjct: 1 MSQKPAKEGPR---LSKNQKYSEHFSIHCCPPFTFL-NSKKEIVDRKYSICKSGCFYQKK 56
Query: 99 EKAWVCCVCQQARLLR 114
E+ W+CC CQ+ RL R
Sbjct: 57 EEDWICCACQKTRLKR 72
>gi|110227631 synaptotagmin-like 3 [Homo sapiens]
Length = 542
Score = 79.7 bits (195), Expect = 1e-14
Identities = 46/136 (33%), Positives = 69/136 (50%), Gaps = 7/136 (5%)
Query: 1 MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELK---QKLDEEGSKCSILSKHQ 57
M +++DLS L + E E +LQV+ RD ++ EEER +LK Q L +G+K +
Sbjct: 1 MAQEIDLSALKELEREAILQVLYRDQAVQNTEEERTRKLKTHLQHLRWKGAK----NTDW 56
Query: 58 QFVEHCCMRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQS 117
+ E CC RC FL++ C C VC C + + AW C VC + R ++ ++
Sbjct: 57 EHKEKCCARCQQVLGFLLHRGAVCRGCSHRVCAQCRVFLRGTHAWKCTVCFEDRNVKIKT 116
Query: 118 LEWFYNNVKSRFKRFG 133
EWFY +F G
Sbjct: 117 GEWFYEERAKKFPTGG 132
>gi|193804862 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 72.0 bits (175), Expect = 2e-12
Identities = 47/145 (32%), Positives = 70/145 (48%), Gaps = 3/145 (2%)
Query: 1 MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFV 60
M LDLS L+++E + +L V+QRD +RK +E+R+ LK +L E K Q +
Sbjct: 1 MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRK-GAKRGSQHYS 59
Query: 61 EHCCMRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQSLEW 120
+ C RC L C C VC+ C Q+ W C VC + L+ + +W
Sbjct: 60 DRTCARCQESLGRLSPKTNTCRGCNHLVCRD-CRIQESNGTWRCKVCAKEIELKKATGDW 118
Query: 121 FYNNVKSRFK-RFGSAKVLKNLYRK 144
FY+ +RF R GS + +L K
Sbjct: 119 FYDQKVNRFAYRTGSEIIRMSLRHK 143
>gi|193804860 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 72.0 bits (175), Expect = 2e-12
Identities = 47/145 (32%), Positives = 70/145 (48%), Gaps = 3/145 (2%)
Query: 1 MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFV 60
M LDLS L+++E + +L V+QRD +RK +E+R+ LK +L E K Q +
Sbjct: 1 MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRK-GAKRGSQHYS 59
Query: 61 EHCCMRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQSLEW 120
+ C RC L C C VC+ C Q+ W C VC + L+ + +W
Sbjct: 60 DRTCARCQESLGRLSPKTNTCRGCNHLVCRD-CRIQESNGTWRCKVCAKEIELKKATGDW 118
Query: 121 FYNNVKSRFK-RFGSAKVLKNLYRK 144
FY+ +RF R GS + +L K
Sbjct: 119 FYDQKVNRFAYRTGSEIIRMSLRHK 143
>gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 68.2 bits (165), Expect = 3e-11
Identities = 43/143 (30%), Positives = 69/143 (48%), Gaps = 7/143 (4%)
Query: 5 LDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFVEHCC 64
++LS L D E E +L V++RD L+K E++R+ +LK +L E + K QQ C
Sbjct: 8 INLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRS---GKTQQEASRVC 64
Query: 65 MRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQSLEWFYNN 124
+ C + + C C VC+ C +W C VC + LR + EWF+
Sbjct: 65 VHCHRNLGLIFDRGDPCQACSLRVCRE-CRVAGPNGSWKCTVCDKIAQLRIITGEWFFEE 123
Query: 125 VKSRFKR---FGSAKVLKNLYRK 144
RFK+ G+ V +++ R+
Sbjct: 124 KAKRFKQVNVLGTDVVRQSILRR 146
>gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens]
Length = 752
Score = 68.2 bits (165), Expect = 3e-11
Identities = 43/143 (30%), Positives = 69/143 (48%), Gaps = 7/143 (4%)
Query: 5 LDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFVEHCC 64
++LS L D E E +L V++RD L+K E++R+ +LK +L E + K QQ C
Sbjct: 8 INLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRS---GKTQQEASRVC 64
Query: 65 MRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQSLEWFYNN 124
+ C + + C C VC+ C +W C VC + LR + EWF+
Sbjct: 65 VHCHRNLGLIFDRGDPCQACSLRVCRE-CRVAGPNGSWKCTVCDKIAQLRIITGEWFFEE 123
Query: 125 VKSRFKR---FGSAKVLKNLYRK 144
RFK+ G+ V +++ R+
Sbjct: 124 KAKRFKQVNVLGTDVVRQSILRR 146
>gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 68.2 bits (165), Expect = 3e-11
Identities = 43/143 (30%), Positives = 69/143 (48%), Gaps = 7/143 (4%)
Query: 5 LDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFVEHCC 64
++LS L D E E +L V++RD L+K E++R+ +LK +L E + K QQ C
Sbjct: 8 INLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRS---GKTQQEASRVC 64
Query: 65 MRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQSLEWFYNN 124
+ C + + C C VC+ C +W C VC + LR + EWF+
Sbjct: 65 VHCHRNLGLIFDRGDPCQACSLRVCRE-CRVAGPNGSWKCTVCDKIAQLRIITGEWFFEE 123
Query: 125 VKSRFKR---FGSAKVLKNLYRK 144
RFK+ G+ V +++ R+
Sbjct: 124 KAKRFKQVNVLGTDVVRQSILRR 146
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 62.8 bits (151), Expect = 1e-09
Identities = 109/476 (22%), Positives = 191/476 (40%), Gaps = 49/476 (10%)
Query: 165 LENEGSISGSDSTFYRQSEGHSVMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASY 224
LE E G + EG + +++ ++V E + + K+E +++Q E +
Sbjct: 406 LEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQ 465
Query: 225 LRDHKEELTEELATTILQKIIRKQKSKSEQQVEEEPGWPHPQSCSTKVADEGTSASPGGY 284
+ EE+TEE ++++K E+ EEE G + + +E T + P
Sbjct: 466 VT---EEVTEE----------EEKEAKEEEGKEEEGG----EEEEAEGGEEETKSPP--- 505
Query: 285 RAPAALWRSQSAFSITGEEALKTPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETNL 344
A A + A S EEA K+P A ++ P + AE P +E
Sbjct: 506 -AEEAASPEKEAKSPVKEEA-KSP---AEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKS 560
Query: 345 APVLQSPDGNWVALKDGAPPPTRLLAKPKSGTFQALEVASSVASAYDEMGSDS---EEDF 401
P +SP+ K+ A P + P+ A E A S A A + S EE
Sbjct: 561 PPEAKSPE------KEEAKSPAE-VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAK 613
Query: 402 DWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAG 461
+EA S + +++ P+ ++ + ++ A SP A SP E S + S
Sbjct: 614 SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEE---AKSPEKAKSPEKEEAKSPEKAKSPV 670
Query: 462 SSREVGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLA-SRETSDSSEPEEAPHTT 520
+ + S ++ +A ++P K + E +P+ A S ++ PE+A
Sbjct: 671 KAEAKSPEKAKSPVKAEA-KSPEKAKSPVKEEAK---SPEKAKSPVKEEAKSPEKAKSPV 726
Query: 521 DRRARRWRRARLGSEEPSKEPSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTE 580
A+ +A+ +E +K P + T V ++T EAR P D
Sbjct: 727 KEEAKTPEKAKSPVKEEAKSPEKAKSP-EKAKTLDVKSPEAKTPAKEEARSP---ADKFP 782
Query: 581 EKRRNRLYELAMKMSEKETSSGEDQESEPKTESENQKESLSSEDNSQSVQEELKKK 636
EK ++ + E +K EK S ++ P+ E +KE + S + +E+K K
Sbjct: 783 EKAKSPVKE-EVKSPEKAKSPLKEDAKAPEKEIP-KKEEVKSPVKEEEKPQEVKVK 836
Score = 48.1 bits (113), Expect = 3e-05
Identities = 94/457 (20%), Positives = 167/457 (36%), Gaps = 39/457 (8%)
Query: 203 EEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATTILQKIIRKQKSKSEQQVEEEPGW 262
EE E S + AS ++ K + EE + K K+++KS +V+
Sbjct: 491 EEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKA 550
Query: 263 PHPQSCSTKVADEGTSASPGGYRAPAALWRSQSAFSITGEEALKTPPVEAPSRQPRDQGQ 322
P K E S ++PA + + A S EEA K+P A ++ P
Sbjct: 551 KSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA-KSP---AEAKSPEKAKS 606
Query: 323 HPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVALKDGAPPPTRLLAK-PKSGTFQALE 381
+ E+ P+ +E ++SP + A PT+ AK P+ E
Sbjct: 607 PVKEEAKSPAEAKSPVKEEAKSPAEVKSP--------EKAKSPTKEEAKSPEKAKSPEKE 658
Query: 382 VASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPI---AA 438
A S A + ++++ + +++ K +S ++P + ++ + P+ A
Sbjct: 659 EAKSPEKAKSPVKAEAKSP-EKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK 717
Query: 439 SPSSALSPNPEAMCSDSETSS-----AGSSREVGHQARLSWLQRKAP--RNPAAEKMRLH 491
SP A SP E + + S A S + + L K+P + PA E+ R
Sbjct: 718 SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777
Query: 492 GELDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEE---PSKEPSSP-SAQ 547
+ F + S + PE+A A+ + EE P KE P +
Sbjct: 778 AD---KFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVK 834
Query: 548 LRDLDTHQVSDDLSETDISNEARD--------PQTLTDTTEEKRRNRLYELAMKMSEKET 599
+++ + T + E +D + EEK+ + + E +
Sbjct: 835 VKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKK 894
Query: 600 SSGEDQESEPKTESENQKESLSSEDNSQSVQEELKKK 636
ED++ P E E + ED + E+ KK
Sbjct: 895 EEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKK 931
Score = 43.5 bits (101), Expect = 8e-04
Identities = 96/474 (20%), Positives = 187/474 (39%), Gaps = 48/474 (10%)
Query: 203 EEAISKAEAYGDSLDK---QNEASYLRDHKEELTEELATTILQKIIRKQKSKSEQQVEEE 259
EEA S AE K + EA + K EE + K K KS ++++ +
Sbjct: 536 EEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSP 595
Query: 260 PGWPHPQSCSTKVADEGTSASPGGY------RAPAALWRSQSAFSITGEEALKTPPVEAP 313
P+ + V +E S + ++PA + + A S T EEA ++P
Sbjct: 596 AEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSP 655
Query: 314 SRQPRDQGQHPRAESALPSWKSVDRLDETNLAPV---LQSPDGNWVALKDGAPPPTRLLA 370
++ + + P E A K+ + E +PV +SP+ +K+ A P + +
Sbjct: 656 EKE---EAKSP--EKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKS 710
Query: 371 KPKSGTFQALEVASSV---ASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQ 427
K + S V A ++ S +E+ E +K +++ L T
Sbjct: 711 PVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEK-AKSPEKAKTLDVKSPEAKTP 769
Query: 428 AQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAAEK 487
A+ + P P A SP E + S + S + + +++ ++P E+
Sbjct: 770 AKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIP--KKEEVKSPVKEE 827
Query: 488 MRLHGELDVNFNPQLASRETSDS---------SEPEEAPHTTDRRARRWRRARLGSEEPS 538
+ E+ V P+ A E + + S+ EEAP + + + E+P
Sbjct: 828 EKPQ-EVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKP- 885
Query: 539 KEPSSPSAQLRDLDTHQVSDDLSETDISNEARD---PQTLTDTTEEKRRNRLYELAMKMS 595
KE + + D +V E E ++ P+ T+ +++ + + K +
Sbjct: 886 KESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPA 945
Query: 596 EKETSSGEDQ----------ESEPKTESENQKESLS-SEDNSQSVQEELKKKFS 638
EK+ ++ E + E +PKTE++ +++ + S++ S+ E+ +K S
Sbjct: 946 EKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSS 999
>gi|154354983 regulating synaptic membrane exocytosis 2 isoform a
[Homo sapiens]
Length = 1349
Score = 56.6 bits (135), Expect = 1e-07
Identities = 59/269 (21%), Positives = 106/269 (39%), Gaps = 24/269 (8%)
Query: 6 DLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLD---EEGSKCSILSKHQQFVEH 62
DLS LT++E + +L V+ R +KE+ L +L Q+ + E+ K S+ QQ +
Sbjct: 28 DLSHLTEEERKIILAVMDRQKKEEEKEQSVLKKLHQQFEMYKEQVKKMGEESQQQQEQKG 87
Query: 63 CCMRC--CSPFTFLVNTKRQCGDCKFNVCKSC---CSYQKHEKAWVCCVCQQARLLRAQS 117
C C F C C+ C C S + ++ WVC +C++ + + +S
Sbjct: 88 DAPTCGICHKTKFADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEILTKS 147
Query: 118 LEWFYNNVKSRFKRFGSAKVLKNL-------YRKHRLESGACFDILGGSLFESNLENEGS 170
WFYN+ S + KVL+ L +K +L F G L +E S
Sbjct: 148 GAWFYNS-GSNTPQQPDQKVLRGLRNEEAPQEKKPKLHEQTQFQGPSGDLSVPAVEKSRS 206
Query: 171 ISGSDSTFYRQSEGHSVMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKE 230
+ + HS+ + V +A + + D + ++ ++ +
Sbjct: 207 --------HGLTRQHSIKNGSGVKHHIASDIASDRKRSPSVSRDQNRRYDQREEREEYSQ 258
Query: 231 ELTEELATTILQKIIRKQKSKSEQQVEEE 259
T + A ++S+ E Q E+
Sbjct: 259 YATSDTAMPRSPSDYADRRSQHEPQFYED 287
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 53.9 bits (128), Expect = 6e-07
Identities = 52/255 (20%), Positives = 107/255 (41%), Gaps = 23/255 (9%)
Query: 374 SGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQ 433
S + + + + S S+ SDS + D S++ S + + + ++SSD
Sbjct: 645 SNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDS 704
Query: 434 GPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAAEKMRLHGE 493
+ S SS S + + SDS++S++ S + + + S + + +++
Sbjct: 705 SDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNS 764
Query: 494 LDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSKEPSSPSAQLRDLDT 553
D S ++SDSS+ ++ +++D + S SS S+ +
Sbjct: 765 SD--------SSDSSDSSDSSDSSNSSD--------SNDSSNSSDSSDSSNSSDSSNSSD 808
Query: 554 HQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTES 613
S D S++D SN + D +D+++ + ++S G D +S +++S
Sbjct: 809 SSDSSDSSDSDSSNSS-DSSNSSDSSDSSNSSD------SSDSSDSSDGSDSDSSNRSDS 861
Query: 614 ENQKESLSSEDNSQS 628
N +S S D+S S
Sbjct: 862 SNSSDSSDSSDSSNS 876
Score = 47.4 bits (111), Expect = 6e-05
Identities = 55/316 (17%), Positives = 122/316 (38%), Gaps = 17/316 (5%)
Query: 314 SRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVALKDGAPPPTRLLAKPK 373
S + + + + + S S D D +N + S D + + + +
Sbjct: 923 SSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNS 982
Query: 374 SGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQ 433
S + + + + S S+ SDS + D S++ + + + N + SSD
Sbjct: 983 SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDS 1042
Query: 434 GPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAAEKMRLHGE 493
+ S S+ S N S++S + S + + S + + +++
Sbjct: 1043 SDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDS 1102
Query: 494 LDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSKEPSSPSAQLRDLDT 553
D + S ++SDSS+ ++ +++D S+ SS S+ D
Sbjct: 1103 SDSS-----DSSDSSDSSDSSDSSNSSD-----------SSDSSDSSDSSDSSNSSDSSD 1146
Query: 554 HQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETS-SGEDQESEPKTE 612
S D S++ S+++ D +D+++ + + + ++S S + +S ++
Sbjct: 1147 SSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSD 1206
Query: 613 SENQKESLSSEDNSQS 628
S + +S S D+S S
Sbjct: 1207 SSDSSDSSDSSDSSDS 1222
Score = 42.0 bits (97), Expect = 0.002
Identities = 41/206 (19%), Positives = 85/206 (41%), Gaps = 6/206 (2%)
Query: 427 QAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREV----GHQARLSWLQRKAPRN 482
++ SSD +S SS S + ++ SDS +SS S + + S + +
Sbjct: 546 KSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSS 605
Query: 483 PAAEKMRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSKEPS 542
+++ D + + +S+ SDSS+ + ++D + S+ + S
Sbjct: 606 DSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNS 665
Query: 543 SPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSSG 602
S S+ D S D S + S+++ D +++++ + + S+ S+
Sbjct: 666 SDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSD--SDSSDSSDSSNSNS 723
Query: 603 EDQESEPKTESENQKESLSSEDNSQS 628
D +S ++S + S S D+S S
Sbjct: 724 SDSDSSNSSDSSDSSNSSDSSDSSDS 749
Score = 40.8 bits (94), Expect = 0.005
Identities = 48/238 (20%), Positives = 86/238 (36%), Gaps = 24/238 (10%)
Query: 391 DEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALSPNPEA 450
D SDS D S++ + + SD +S SS + +
Sbjct: 551 DSDSSDSSNSSDSSDSSD-----------SDSSDSNSSSDSDSSDSDSSDSSDSDSSDSS 599
Query: 451 MCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLASRETSDS 510
SDS SS S + S + +++ D N + + ++SDS
Sbjct: 600 NSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDS 659
Query: 511 SEPEEAPHTTDRRARRWRRARLGSEEPSKEPSSPSAQLRDLDTHQVSDDLSETDISNEAR 570
S + ++D S+ SS S+ D S + SE+ S+++
Sbjct: 660 SNSSNSSDSSD-----------SSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSS 708
Query: 571 DPQTLTDTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESENQKESLSSEDNSQS 628
D + +D+++ N + S+ SS S+ ++S N +S S D+S S
Sbjct: 709 DSDS-SDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSD-SSDSSNSSDSSDSSDSSNS 764
Score = 40.8 bits (94), Expect = 0.005
Identities = 52/253 (20%), Positives = 104/253 (41%), Gaps = 27/253 (10%)
Query: 383 ASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSS 442
+S+ + + D SDS + S++ S S + + + SSD + S S
Sbjct: 557 SSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDS 616
Query: 443 ALSPNPEAMCSDSETSSAGS-SREVGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQ 501
+ S + ++ S SE+ S+ S S+ + S + + ++ N +
Sbjct: 617 SDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSS--------NSSDS 668
Query: 502 LASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSKEPSSPSAQLRDLDTHQVSD--- 558
S ++SDSS ++ +++D + S+ + SS S+ D D+ SD
Sbjct: 669 SDSSDSSDSSSSSDSSNSSD--------SSDSSDSSNSSESSDSSDSSDSDSSDSSDSSN 720
Query: 559 -DLSETDISN--EARDPQTLTDTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESEN 615
+ S++D SN ++ D +D+++ + + S+ SS S+ S++
Sbjct: 721 SNSSDSDSSNSSDSSDSSNSSDSSDSSDSSN----SSDSSDSSDSSNSSDSSDSSDSSDS 776
Query: 616 QKESLSSEDNSQS 628
S SS+ N S
Sbjct: 777 SDSSNSSDSNDSS 789
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 52.8 bits (125), Expect = 1e-06
Identities = 99/461 (21%), Positives = 160/461 (34%), Gaps = 86/461 (18%)
Query: 247 KQKSKSEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSAFSITGEEALK 306
KQKSK+ + PHP+ S +G+ SP R +S F + + LK
Sbjct: 824 KQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQR-RSCFESSPDPELK 882
Query: 307 TPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETN------LAPVLQSPDGNWVALKD 360
+ PSR PR +S+ P +S R ++P +S G+
Sbjct: 883 S---RTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGS------ 933
Query: 361 GAPPPTRLLAKPKSGTFQALEVASSVAS----AYDEMGSDSEEDFDWSEALSKLCPRSRA 416
+P P+R+ ++ +++ S+V S Y GS S P ++
Sbjct: 934 SSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSS--------------PDTKV 979
Query: 417 LPRNPQPQPTQAQSSD------QGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQA 470
P P Q S Q P S S + SP P+ DS S S
Sbjct: 980 KPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGS------- 1032
Query: 471 RLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLASRETSDSSEPE------EAPHTTDRRA 524
LS P E L + Q + SD+S PE E+P +
Sbjct: 1033 -LSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQ 1091
Query: 525 RRWRRARLGSEEPSKEPSSPSAQLRDLDTHQV----------------SDDLSETDISNE 568
+ R S P E +S S +D SD S + +
Sbjct: 1092 TSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSN 1151
Query: 569 ARDPQTLTDTTEEKRRNRLYELAMKMSEKETSSGEDQESE--PKTESENQKESLSSED-- 624
+ Q+ +T E K + +A+ E T+S Q+ + P + + SL +D
Sbjct: 1152 SLLGQSRLETAESKEK-----MALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTL 1206
Query: 625 -------NSQSVQEELKKKFSAVSLCNISTEVLKVINATEE 658
+ E K++ SA+ + E+++V+ +EE
Sbjct: 1207 RTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEE 1247
Score = 46.2 bits (108), Expect = 1e-04
Identities = 94/448 (20%), Positives = 165/448 (36%), Gaps = 67/448 (14%)
Query: 207 SKAEAYGDSLDKQNEASYLRDHKEELTEELATTILQKIIR---KQKSKSEQQVEEEPGWP 263
S +E D+++K +S + +++ +L + R +++S S E + G P
Sbjct: 1382 SSSELSPDAVEKAGMSS---------NQSISSPVLDAVPRTPSRERSSSASSPEMKDGLP 1432
Query: 264 HPQSCSTKVADEGTSASPGGYRAPAALWRSQSAFSITGEEALKTPPVEAPSR-----QPR 318
S ++ + +SPG R + S G + + P S +P+
Sbjct: 1433 RTPSRRSR-----SGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPK 1487
Query: 319 DQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVALKDGAPPPTRLLAKPKSGTFQ 378
Q PR S PS L+ L P + G+ ++ T L + +SG+ Q
Sbjct: 1488 ALPQTPRPRSRSPS---SPELNNKCLTPQRER-SGSESSVDQKTVARTPLGQRSRSGSSQ 1543
Query: 379 ALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRA-----LPRNPQPQPTQAQSSDQ 433
L+V S AS + SDS D ++ + L RSR+ + + P +++S
Sbjct: 1544 ELDVKPS-ASPQERSESDSSPDSK-AKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSS 1601
Query: 434 GPIAASPSSA--------LSPNPEAMCSDS---ETSSAGSSREVGHQARLSWLQRKAPRN 482
+ P +A SP P+A + + S SS+ G S +P +
Sbjct: 1602 PEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEH 1661
Query: 483 PAAEKMRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSKEPS 542
P + G + P+ SR +P T R+AR RR+R S S
Sbjct: 1662 PPKSRTARRGSRS-SPEPKTKSRTPPRRRSSRSSPELT-RKARLSRRSRSAS-------S 1712
Query: 543 SPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSSG 602
SP + R H+ R P + EK R+ + +T+S
Sbjct: 1713 SPETRSRTPPRHR--------------RSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSR 1758
Query: 603 EDQESEPKTESENQKESLSSEDNSQSVQ 630
+ PK + S S + +++ +
Sbjct: 1759 RGRSPSPKPRGLQRSRSRSRREKTRTTR 1786
Score = 37.0 bits (84), Expect = 0.078
Identities = 49/216 (22%), Positives = 83/216 (38%), Gaps = 34/216 (15%)
Query: 363 PPPTRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWS-----EALSKLCPRSRAL 417
P R + S + + +SS +S+ GS S + S E K P
Sbjct: 2526 PAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPA 2585
Query: 418 P-------RNPQPQPTQ-------------AQSSDQGPIAASPSSALSPNPEAMCSDSET 457
P R P+P P + + SS ++S SS+ S + + S S +
Sbjct: 2586 PKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2645
Query: 458 SSAGSSREVGHQARLSWLQRKAP-------RNPAAEKMRLHGELDVNFNPQLASRETSDS 510
SS+ S + G QA K P R+P L ++++P R +
Sbjct: 2646 SSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQP 2705
Query: 511 SEPEEAPHTTDRRARRWRR--ARLGSEEPSKEPSSP 544
S ++ +++R +RR +R +R S + +E SP
Sbjct: 2706 SPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSP 2741
Score = 36.6 bits (83), Expect = 0.10
Identities = 96/470 (20%), Positives = 156/470 (33%), Gaps = 64/470 (13%)
Query: 200 EAIEEAISKAEAY--GDSLDKQNEASYLRDHKEE------LTEELAT----TILQKIIRK 247
E + A +++Y G S D Q A + E L E ++ T QK +K
Sbjct: 133 ERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKK 192
Query: 248 QKSKSEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSAFSITGEEALKT 307
+K + + P +S K + + +R+P + +S ++ K
Sbjct: 193 KKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSK-----DKKRKR 247
Query: 308 PPVEAPSRQPRDQGQHPRAESALPSWKSVDR-------LDETNLAPVLQSPDGNWVALKD 360
P+ + R + A+SA S S R T LA SP D
Sbjct: 248 SRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGD 307
Query: 361 G--APPPTRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALP 418
+ P T +P S +S Y++ D +E + S RS P
Sbjct: 308 APFSEPGTTSTQRPSSPE----TATKQPSSPYEDKDKDKKEKSATRPSPSP--ERSSTGP 361
Query: 419 RNPQPQPTQAQ--SSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQ 476
P P P A+ P+A +P S NP + S + S S E Q+ S
Sbjct: 362 EPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSS--- 418
Query: 477 RKAPRNPAAEKMRLH---------------GELDVNFNPQLASRETSDSSEPEEAPHTTD 521
+P +P K+ H +++ +P +R + + HT
Sbjct: 419 ESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPS 478
Query: 522 RRARRWR------RARLGSEEPSK--EPSSPSAQLRDLDTHQVSDDLSETDISNEARDPQ 573
RR R R R R S P+K S S Q R + Q +R PQ
Sbjct: 479 RRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQ 538
Query: 574 ----TLTDTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESENQKES 619
+ + T+ + R+R S + G + P ++ +
Sbjct: 539 RPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRT 588
Score = 36.2 bits (82), Expect = 0.13
Identities = 65/319 (20%), Positives = 114/319 (35%), Gaps = 39/319 (12%)
Query: 306 KTPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVALKDGAPPP 365
+TPP APS+ + P S + S ++ L P P +P P
Sbjct: 2408 RTPP-SAPSQSRMTSERAPSPSSRMGQAPS-----QSLLPPAQDQPR---------SPVP 2452
Query: 366 TRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQP 425
+ + + Q VA S + + + + + D + LS P +P + +P
Sbjct: 2453 SAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAP---GVPHSDVGEP 2509
Query: 426 TQAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAA 485
+ + Q S +AL P E S S +SS+ SS + S + +
Sbjct: 2510 PASTGAQQ----PSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEG 2565
Query: 486 EKMRLHGELDVNF--NPQLASRET-SDSSEPEEAPHTTDRRARRWRRARLGSEEPSKEPS 542
+ + E+ + +P A +E + PE P A+R RR+ S S S
Sbjct: 2566 SSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTP------AKRKRRSSSSSSSSSSSSS 2619
Query: 543 SPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSSG 602
S S+ + S S + S+ + P + L S K+ G
Sbjct: 2620 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQ--------ALPKPASPKKPPPG 2671
Query: 603 EDQESEPKTESENQKESLS 621
E + P+ ++ ++S S
Sbjct: 2672 ERRSRSPRKPIDSLRDSRS 2690
Score = 35.0 bits (79), Expect = 0.30
Identities = 85/390 (21%), Positives = 128/390 (32%), Gaps = 52/390 (13%)
Query: 269 STKVADEGTSASPG----GYRAPAALWRSQSAFSITGEEALKTPPVEAPSRQPRDQGQHP 324
+ +AD T +P G R PAAL +A S+TG TPP A Q P
Sbjct: 2281 AVNLADPRTPTAPAVNLAGARTPAAL----AALSLTGSG---TPPTAANYPSSSRTPQAP 2333
Query: 325 RAESALPSWKSVDRLDETNLAPVLQSPDGNWVALKDGAPPPTRLLAKPKSGTFQALEVAS 384
A + L +S N+A G+ A A P L + + + S
Sbjct: 2334 -ASANLVGPRSAHATAPVNIA-------GSRTA---AALAPASLTSARMAPALSGANLTS 2382
Query: 385 SVA--SAYDEM-GSDSEEDFDWSEALSKLCPRSRAL---PRNPQPQPTQAQSSDQGPIAA 438
SAY+ + G S D + + + S++ R P P Q+ Q +
Sbjct: 2383 PRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPP 2442
Query: 439 SPSSALSPNPEAM-----CSDSETSSAGSSREVG-------------HQARLSWLQRKAP 480
+ SP P A C ++T+ S+ + H LS P
Sbjct: 2443 AQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVP 2502
Query: 481 RNPAAEKMRLHGELDVNFNPQL--ASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPS 538
+ E G + L A S SS + ++ + + GS
Sbjct: 2503 HSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSD 2562
Query: 539 KEPSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKE 598
E SS Q S + + E R P + T KR+ R + S
Sbjct: 2563 SEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPP----EPTPAKRKRRSSSSSSSSSSSS 2618
Query: 599 TSSGEDQESEPKTESENQKESLSSEDNSQS 628
+SS S + S + S SS +S S
Sbjct: 2619 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2648
Score = 33.9 bits (76), Expect = 0.66
Identities = 97/471 (20%), Positives = 164/471 (34%), Gaps = 63/471 (13%)
Query: 166 ENEGSISGSDS-TFYRQSEGHSVMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASY 224
E GS S D T R G + L V A + S++++ DS K
Sbjct: 1515 ERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLR 1574
Query: 225 LRDHKEELTEELATTILQKIIRKQKSKSEQQVEEEPGWPHPQSCSTKVADEGTSASPGGY 284
R E + + L R+ +S S +V+++P + A G+ +SP
Sbjct: 1575 QRSRSGSSPEVDSKSRLSP--RRSRSGSSPEVKDKPR-------AAPRAQSGSDSSPEP- 1624
Query: 285 RAPAALWRSQSAFSITGEEALKTPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETNL 344
+APA R+ S +G + P S +HP P ++ R ++
Sbjct: 1625 KAPAP--RALPRRSRSGSSSKGRGPSPEGSSSTESSPEHP------PKSRTARRGSRSSP 1676
Query: 345 APVLQSPDGNWVALKDGAPPPTRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWS 404
P +S PP R ++ + ++ SA
Sbjct: 1677 EPKTKS-----------RTPPRRRSSRSSPELTRKARLSRRSRSASSS-----------P 1714
Query: 405 EALSKLCPRSRALPRNPQPQPTQ-AQSSDQGPIAASPSS--------ALSPNPEAMCSDS 455
E S+ PR R P P+P + ++SS + A+SP + + SP P +
Sbjct: 1715 ETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSR 1774
Query: 456 ETSSAGSSREVGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLASRETSDSSEPEE 515
S +R + R Q + R + R V + S S S +E
Sbjct: 1775 SRSRREKTRTTRRRDRSGSSQSTSRR-----RQRSRSRSRVTRRRRGGSGYHSRSPARQE 1829
Query: 516 APHTTDRRARRWRRARLGSEEPSKEPSSPSAQLRDLD-----THQVSDDLSETDISNEAR 570
+ T+ RR R R S + S+ +SP+ R TH+ S S T + + R
Sbjct: 1830 SSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRS--RSRTPLISRRR 1887
Query: 571 DPQTLTDTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESENQKESLS 621
+ + + R+R + + S S + S +T ++ S S
Sbjct: 1888 SRSRTSPVSRRRSRSRT-SVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRS 1937
Score = 32.7 bits (73), Expect = 1.5
Identities = 53/221 (23%), Positives = 89/221 (40%), Gaps = 19/221 (8%)
Query: 246 RKQKSKSEQQVEEEPGWPHPQSCSTKVADEGTSASPGGY-RAPAALWRSQSAFSITGEEA 304
RK KS++ Q+ P + + +SP ++ +L RS S S ++
Sbjct: 730 RKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQK 789
Query: 305 LKTPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVALKDGAPP 364
+TPP R+ R P+A+S P +S ++ P +S + + +P
Sbjct: 790 SQTPP-----RRSRSGSSQPKAKSRTPPRRS---RSSSSPPPKQKSKTPSRQSHSSSSPH 841
Query: 365 PTRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQ 424
P K KSGT +S + + F+ S +L R+ +
Sbjct: 842 P-----KVKSGTPPRQGSITSPQANEQSVTPQRRSCFE-SSPDPELKSRTPSRHSCSGSS 895
Query: 425 PTQAQSSDQGPIAASPSSALSPNP--EAMCSDSETSSAGSS 463
P + +SS P SPS + SP P +A+ S + S +GSS
Sbjct: 896 PPRVKSST--PPRQSPSRSSSPQPKVKAIISPRQRSHSGSS 934
>gi|5902064 rabphilin 3A-like (without C2 domains) [Homo sapiens]
Length = 315
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/119 (27%), Positives = 56/119 (47%), Gaps = 9/119 (7%)
Query: 10 LTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFVEHCCMRCCS 69
L+ E E +LQV+QR L E++R+ L ++L E + +++ C+ C
Sbjct: 47 LSPAEVEAILQVIQRAERLDVLEQQRIGRLVERL--ETMRRNVMGNGLS----QCLLCGE 100
Query: 70 PFTFLVNTKRQCGDCKFNVCKSC---CSYQKHEKAWVCCVCQQARLLRAQSLEWFYNNV 125
FL ++ C DC+ VC C S + W+C +C + R + +S WFY +
Sbjct: 101 VLGFLGSSSVFCKDCRKKVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGL 159
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 52.0 bits (123), Expect = 2e-06
Identities = 116/534 (21%), Positives = 181/534 (33%), Gaps = 84/534 (15%)
Query: 196 RVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATTILQKIIRKQKSKSEQQ 255
+ A +A E + S+ + D + Q + + K + A K + S S+
Sbjct: 118 KAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPP---KKAKSSDSDSDSS 174
Query: 256 VEEEPG-------WPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSAFSITG-----EE 303
E+EP P TK + A+P AA S S+ S + E+
Sbjct: 175 SEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEK 234
Query: 304 ALKTPPVEAPSRQ-----PRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVAL 358
A TP P +Q P P +S+ S D +E P+ P
Sbjct: 235 AAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDE-EEEQKKPMKNKPGPYSSVP 293
Query: 359 KDGAPPPTRLLAK--PKSGTFQALEVASSVASAYDEMGSDSEEDFD------WSEALSKL 410
APPP + L PK + V SS S+ DE S SEE+ S+A +K
Sbjct: 294 PPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSS-DESDSSSEEEKKPPTKAVVSKATTKP 352
Query: 411 CPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSDSET--SSAGSSREVGH 468
P +A + + + D+ P + ++ S N A+ + S +A + VG
Sbjct: 353 PPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGG 412
Query: 469 QARLSWLQRKAPRNPAAEKMRLHGE---------------------LDVNFNPQLA--SR 505
+L L RKA + + E+ E L PQ + S
Sbjct: 413 GQKL--LTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSS 470
Query: 506 ETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSKEPSSPSAQLRDLDTHQVSDDLSETDI 565
SDSS EE T + A + + ++ +P+S + SDD SE +
Sbjct: 471 SDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEE- 529
Query: 566 SNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESENQKESLSSEDN 625
EEK + + TS+ Q + SE ++E
Sbjct: 530 --------------EEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAV 575
Query: 626 SQSVQEELKKKFSAVSLCNISTEVLKVINATEELIAGSTGPWESPQVPPDRQKG 679
S LKK+ + T K I ++P P R+KG
Sbjct: 576 VVSKSGSLKKRKQNEAAKEAETPQAKKIKL------------QTPNTFPKRKKG 617
Score = 46.6 bits (109), Expect = 1e-04
Identities = 75/372 (20%), Positives = 136/372 (36%), Gaps = 40/372 (10%)
Query: 269 STKVADEGTSAS-PGGYRAPAALWRSQSAFSITGEEALKTPPVEAPSRQPRDQGQHPRAE 327
S KV + A+ P +A S S S EE ++ PP + + P
Sbjct: 60 SAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAK--------KAAVPAKR 111
Query: 328 SALPSWKSVDRLDETNLAPVLQSPDGNWVALKDGAPPPTRLLAKPKSGTFQALEVASSVA 387
LP K+ + E++ + D +D P + KP++ +A + A
Sbjct: 112 VGLPPGKAAAKASESSSSEESSDDDDE----EDQKKQPVQKGVKPQA---KAAKAPPKKA 164
Query: 388 SAYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALSPN 447
+ D S ED K+ P + P+P +A AAS SS+ S +
Sbjct: 165 KSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSS 224
Query: 448 PEAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLASRET 507
+ S+ E ++A + V + ++ KAP A R + +S E
Sbjct: 225 SSSDDSEEEKAAATPKKTVPKKQVVA----KAPVKAATTPTR-----------KSSSSED 269
Query: 508 SDSSEPEEAPHTTDRRARRWRRARLGSEEPSKE------PSSPSAQLRDLDTHQVSDDLS 561
S S E EE + + S P K+ P + + +++ + S D S
Sbjct: 270 SSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDES 329
Query: 562 ETDISNEARDPQTLT---DTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESENQKE 618
++ E + P TT+ + E + S+ ++S ++ S+P ++N
Sbjct: 330 DSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSN 389
Query: 619 SLSSEDNSQSVQ 630
+ S +V+
Sbjct: 390 KPAVTTKSPAVK 401
>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
Length = 694
Score = 49.7 bits (117), Expect = 1e-05
Identities = 30/115 (26%), Positives = 53/115 (46%), Gaps = 8/115 (6%)
Query: 10 LTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFVEHCCMRCCS 69
LTD+E E + +V+ R + + E+ER+ L +L+ + ++ C+ C
Sbjct: 50 LTDEEKEIINRVIARAEKMEEMEQERIGRLVDRLENMRKNVAGDGVNR------CILCGE 103
Query: 70 PFTFLVNTKRQCGDCKFNVCKSCC--SYQKHEKAWVCCVCQQARLLRAQSLEWFY 122
L + C DCK NVC C + + W+C +C + R + +S WF+
Sbjct: 104 QLGMLGSACVVCEDCKKNVCTKCGVETNNRLHSVWLCKICIEQREVWKRSGAWFF 158
>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
Length = 690
Score = 49.7 bits (117), Expect = 1e-05
Identities = 30/115 (26%), Positives = 53/115 (46%), Gaps = 8/115 (6%)
Query: 10 LTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFVEHCCMRCCS 69
LTD+E E + +V+ R + + E+ER+ L +L+ + ++ C+ C
Sbjct: 46 LTDEEKEIINRVIARAEKMEEMEQERIGRLVDRLENMRKNVAGDGVNR------CILCGE 99
Query: 70 PFTFLVNTKRQCGDCKFNVCKSCC--SYQKHEKAWVCCVCQQARLLRAQSLEWFY 122
L + C DCK NVC C + + W+C +C + R + +S WF+
Sbjct: 100 QLGMLGSACVVCEDCKKNVCTKCGVETNNRLHSVWLCKICIEQREVWKRSGAWFF 154
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 48.9 bits (115), Expect = 2e-05
Identities = 98/511 (19%), Positives = 183/511 (35%), Gaps = 77/511 (15%)
Query: 301 GEEALKTPPV------EAPSRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGN 354
G E +PP+ ++P R + + P+ P WK + L E + A S
Sbjct: 466 GLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAA----SLSLQ 521
Query: 355 WVALKDGAPPPTRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRS 414
++ AP P K K QA +E+G EE D E +
Sbjct: 522 LSLQREQAPSPPAACEKGKEQHSQA-----------EELGPGQEEAEDPEEKV------- 563
Query: 415 RALPRNPQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSW 474
A+ P P + P +AL EA+ E Q ++
Sbjct: 564 -AVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLE--SKQEKMQQ 620
Query: 475 LQRKAPRNPAAEKMRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRARR--WRRARL 532
L+ K + E +RLH + + + + + RE + EE + ++R W RA++
Sbjct: 621 LREKLCQEEEEEILRLHQQKEQSLS---SLRERLQKAIEEEEARMREEESQRLSWLRAQV 677
Query: 533 GSEEPSKEPSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAM 592
S + E + Q + ++ ++L + A + E+K R L +L
Sbjct: 678 QSSTQADEDQIRAEQ--EASLQKLREELESQQKAERA--------SLEQKNRQMLEQLKE 727
Query: 593 KMSEKETSSGEDQESEPKTESENQKESLSSEDNSQSVQEELKKKFSAVSLC-NISTEVLK 651
++ E S + + + +E L E E + LC ++ + +
Sbjct: 728 EIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHRE 787
Query: 652 VINATEELIAGSTGPWESPQVPPDRQKGMFPRGTDQVRLDEQLTSLEENVYLAAGTVYGL 711
V+++ ++ ++ +QK ++ +L + L +E V+ + V G
Sbjct: 788 VVSSLQK------------KIQEAQQK-------EEAQLQKCLGQVEHRVHQKSYHVAGY 828
Query: 712 ETQLTELEDAARCIHSGTDETHLADLEDQVATAAAQVHHAELQISDIESRISALTIAGLN 771
E +L+ L R G E L D++ QV + + E R + G
Sbjct: 829 EHELSSLLREKRQEVEGEHERRL----DKMKEEHQQVMAKAREQYEAEERKQRAELLG-- 882
Query: 772 IAPCVRFTRRRDQKQRTQVQTIDTSRQQRRK 802
T ++ QR + ++T RQ++ K
Sbjct: 883 -----HLTGELERLQRAHERELETVRQEQHK 908
Score = 40.0 bits (92), Expect = 0.009
Identities = 58/242 (23%), Positives = 90/242 (37%), Gaps = 31/242 (12%)
Query: 400 DFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSDSETSS 459
DF++ E+L R QP+ + S D AA P + P+ +DS SS
Sbjct: 251 DFEYEESL-----------RTSQPEEKKDVSLDSD--AAGPPTPCKPSSPG--ADSSLSS 295
Query: 460 AGSSREVGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLASRETSDSSEPEEAPHT 519
A G AR +++ N +E + +P E + +SE E T
Sbjct: 296 AVGKGRQGSGARPGLPEKE--ENEKSEPKICRNLVTPKADP--TGSEPAKASEKEAPEDT 351
Query: 520 TDRRARRWRRARLGSEEPSKEPSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTT 579
D RR EE +KEP ++ L + SD E +IS ++PQ
Sbjct: 352 VDAGEEGSRR-----EEAAKEPKKKASALEEGS----SDASQELEISEHMKEPQLSDSIA 402
Query: 580 EEKRRNRLYELAMKMSEKETSSGEDQESEP---KTESENQKESLSSEDNSQSVQEELKKK 636
+ + + + E D S Q + +D+SQS Q+EL+ K
Sbjct: 403 SDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSK 462
Query: 637 FS 638
S
Sbjct: 463 QS 464
Score = 30.4 bits (67), Expect = 7.3
Identities = 50/253 (19%), Positives = 94/253 (37%), Gaps = 24/253 (9%)
Query: 389 AYDEMGSDSEEDFDWS--EALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALSP 446
A +G + ++D S E SK +S+ L P + + P + +
Sbjct: 440 AQQPLGIEDKDDSQSSQDELQSK---QSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQ 496
Query: 447 NPEAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAA-EKMRLHGELDVNFNPQLASR 505
PE E G +LS + +AP PAA EK + P +
Sbjct: 497 GPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGP---GQ 553
Query: 506 ETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSKEPSSPSAQLRDLDTHQVSDDLSETDI 565
E ++ E + A T + E S EP +P QL + + + +++
Sbjct: 554 EEAEDPEEKVAVSPT---------PPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQV-- 602
Query: 566 SNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESENQKESLSSEDN 625
+D + L ++ +EK + +L + E+E Q+ E S ++ + E+
Sbjct: 603 --LEQDQRHLLESKQEKMQQLREKLCQE--EEEEILRLHQQKEQSLSSLRERLQKAIEEE 658
Query: 626 SQSVQEELKKKFS 638
++EE ++ S
Sbjct: 659 EARMREEESQRLS 671
>gi|48255931 hepatoma-derived growth factor-related protein 2
isoform 1 [Homo sapiens]
Length = 671
Score = 48.5 bits (114), Expect = 3e-05
Identities = 67/284 (23%), Positives = 103/284 (36%), Gaps = 38/284 (13%)
Query: 386 VASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALS 445
VA A S S S+ K PR R P P+P + + P ++S S
Sbjct: 248 VAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSD--- 304
Query: 446 PNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLASR 505
SDS+ S + +AR L+ + R E RL + + R
Sbjct: 305 -------SDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLR---EQEKEEKERRR 354
Query: 506 ETSDSSEPEEAP--------HTTDRRARRWRRARLGSEEPSKEPSSPSAQLRDLDTHQVS 557
E +D E E D ++ R G PS S P A+L
Sbjct: 355 ERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAEL--------- 405
Query: 558 DDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESENQK 617
E + A+ PQ + +TE R+ E ++ EK+ + E K
Sbjct: 406 ----EREAKKSAKKPQ--SSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSM 459
Query: 618 ESLSSEDNSQSVQEELKKKFSAV--SLCNISTEVLKVINATEEL 659
+ + SV+E+L+K S + +L S +V + +NA EEL
Sbjct: 460 DRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEEL 503
Score = 30.4 bits (67), Expect = 7.3
Identities = 29/112 (25%), Positives = 47/112 (41%), Gaps = 7/112 (6%)
Query: 534 SEEPSKEPSSPSAQLRDLDTHQVSDDLSETDISNEAR-----DPQTLTDTTEEKRRNRLY 588
SE P P+ S D + V + T + R D +D + KR+
Sbjct: 103 SEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPAL 162
Query: 589 ELAMKMSEKETSSGEDQESEPKTESENQKESLSSEDNSQSVQEELKKKFSAV 640
++++ ++ SS DQ S +E EN + S SE S Q+ +K +AV
Sbjct: 163 KMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSD--QDFTPEKKAAV 212
>gi|14249158 hepatoma-derived growth factor-related protein 2
isoform 2 [Homo sapiens]
Length = 670
Score = 48.5 bits (114), Expect = 3e-05
Identities = 67/284 (23%), Positives = 103/284 (36%), Gaps = 38/284 (13%)
Query: 386 VASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALS 445
VA A S S S+ K PR R P P+P + + P ++S S
Sbjct: 248 VAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSD--- 304
Query: 446 PNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLASR 505
SDS+ S + +AR L+ + R E RL + + R
Sbjct: 305 -------SDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLR---EQEKEEKERRR 354
Query: 506 ETSDSSEPEEAP--------HTTDRRARRWRRARLGSEEPSKEPSSPSAQLRDLDTHQVS 557
E +D E E D ++ R G PS S P A+L
Sbjct: 355 ERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAEL--------- 405
Query: 558 DDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESENQK 617
E + A+ PQ + +TE R+ E ++ EK+ + E K
Sbjct: 406 ----EREAKKSAKKPQ--SSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSM 459
Query: 618 ESLSSEDNSQSVQEELKKKFSAV--SLCNISTEVLKVINATEEL 659
+ + SV+E+L+K S + +L S +V + +NA EEL
Sbjct: 460 DRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEEL 503
Score = 30.4 bits (67), Expect = 7.3
Identities = 29/112 (25%), Positives = 47/112 (41%), Gaps = 7/112 (6%)
Query: 534 SEEPSKEPSSPSAQLRDLDTHQVSDDLSETDISNEAR-----DPQTLTDTTEEKRRNRLY 588
SE P P+ S D + V + T + R D +D + KR+
Sbjct: 103 SEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPAL 162
Query: 589 ELAMKMSEKETSSGEDQESEPKTESENQKESLSSEDNSQSVQEELKKKFSAV 640
++++ ++ SS DQ S +E EN + S SE S Q+ +K +AV
Sbjct: 163 KMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSD--QDFTPEKKAAV 212
>gi|55741849 WD repeat domain 22 [Homo sapiens]
Length = 942
Score = 47.8 bits (112), Expect = 4e-05
Identities = 61/252 (24%), Positives = 108/252 (42%), Gaps = 52/252 (20%)
Query: 414 SRALPRNPQPQPTQAQSSDQ----GPIAASPSSALSPNPEA-MCSDSETSSAGSSREVGH 468
S +LPR+P P T +S+D GP+ + ++ ++ P C D+ +
Sbjct: 462 SASLPRSPPP--TVDESADNAFHLGPLRVTTTNTVASTPPTPTCEDAAS----------R 509
Query: 469 QARLSWLQRKAPRNPAA-------EKMRLHGELDVNF-------NPQLASRETSDSSEPE 514
Q RLS L+R + A E+ ELD + +P+ S +S SS E
Sbjct: 510 QQRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSE 569
Query: 515 EAPHTTDRRARRWRRARLGSEEPSKEPSSPSAQLRDLDTH---------QVS-DDLSETD 564
+ +RRA W+R + + + PSA ++ +T+ Q+ DDLS +
Sbjct: 570 DEEELNERRASTWQRNAMRRRQKTTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSP 629
Query: 565 ISNEARDPQTL-------TDTTE-EKRRNRLYELA--MKMSEKETSSGEDQESEPKT-ES 613
S+ R TL + T++ E ++Y+ ++ S S+ +D E+ T E+
Sbjct: 630 TSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGETSLVTGEA 689
Query: 614 ENQKESLSSEDN 625
+ + S +DN
Sbjct: 690 DEGRAGTSHKDN 701
>gi|239754474 PREDICTED: similar to mucin [Homo sapiens]
Length = 417
Score = 47.0 bits (110), Expect = 8e-05
Identities = 73/344 (21%), Positives = 129/344 (37%), Gaps = 26/344 (7%)
Query: 300 TGEEALKTPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVALK 359
TG+ A + +D+ + A A ++ DR +E APV S K
Sbjct: 47 TGQRRGSGSSPSADQQGAQDREEEAAAAPAADQQRAQDREEEAAAAPVPTSSGHRTEKRK 106
Query: 360 DGAPPPTRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRA--L 417
+L +P GT Q SS SA + D EE EA + P SR
Sbjct: 107 R-----LQLQCQPAGGTGQRRGSRSS-PSADQQRAQDREE-----EAAAAPVPTSRGHRT 155
Query: 418 PRNPQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQR 477
+ + QP + + G S SS + A + E ++A + GH+ ++
Sbjct: 156 EKRKRQQPQRRPAGGTGQRRGSGSSPSADQQGAQDREEEAAAAPAPTSRGHRT-----EK 210
Query: 478 KAPRNPAAEKMRLHGELDVNFNPQLASRETSDSSEPEEA--PHTTDRRARRWRRARLGSE 535
+ P+ P G+ + + A ++ + E E A P T R R +R +
Sbjct: 211 RKPQQPQCRPAGGTGQRRGSRSSPSADQQRAQDREEEAAAAPAPTSRGHRTEKRK---PQ 267
Query: 536 EPSKEPSSPSAQLRDLDTHQVSDDLSETDISNEAR---DPQTLTDTTEEKRRNRLYELAM 592
+P + P+ + Q R +D D EA P + TE+++R +L
Sbjct: 268 QPQRRPAGGTGQRRGSGYSPSADQQGAQDREEEAAAAPAPTSSGHRTEKRKRLQLQCQPA 327
Query: 593 KMSEKETSSGEDQESEPKTESENQKESLSSEDNSQSVQEELKKK 636
+ + SG + + + ++E+ ++ + S K+K
Sbjct: 328 GGTGQRRGSGCSSSANQQGAQDREEEAAAAPVPTSSGHRTEKRK 371
>gi|239743051 PREDICTED: hypothetical protein XP_002342747 [Homo
sapiens]
Length = 306
Score = 47.0 bits (110), Expect = 8e-05
Identities = 61/251 (24%), Positives = 100/251 (39%), Gaps = 25/251 (9%)
Query: 341 ETNLAPVLQSPDGN-WVALKDGAP--PPTRLLAKPKSGTFQALEVASSVASAYDEMGSDS 397
+T L + +S +G+ W+ + P P + +P GT Q SS ++ D+ G+
Sbjct: 9 DTRLRKLRESSEGDQWLENEKTKPLRPQQQPQCQPAGGTGQRRGSGSSPSA--DQQGAQD 66
Query: 398 EEDFDWSEALSKLCPRSRAL---PRNPQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSD 454
E+ EA + P SR R PQ QP + + G S SS+ + A +
Sbjct: 67 REE----EAAAAPAPTSRGHRTEKRKPQ-QPQRRPAGGTGQRRGSRSSSSADQQGAQDRE 121
Query: 455 SETSSAGSSREVGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLAS---RETSDSS 511
E ++A + GH+ Q+ R A R + + Q A E + +
Sbjct: 122 EEAAAAPAPTSSGHRTEKRKPQQPQCRPAAGTGQRRGSGCSPSADQQRAQDREEEATAAP 181
Query: 512 EPEEAPHTTDRRARRWRRA--------RLGSEE-PSKEPSSPSAQLRDLDTHQVSDDLSE 562
P + H T++R R + R GS PS++P+ + Q R + +D
Sbjct: 182 VPTSSGHRTEKRKRLQLQCQPAGGTGQRRGSRSSPSRQPAGGTGQRRGSRSSPSADQQRA 241
Query: 563 TDISNEARDPQ 573
D EA PQ
Sbjct: 242 QDREEEAAQPQ 252
Score = 36.2 bits (82), Expect = 0.13
Identities = 46/244 (18%), Positives = 89/244 (36%), Gaps = 16/244 (6%)
Query: 396 DSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSDS 455
+S E W E + P PQ QP + G S SS + A +
Sbjct: 17 ESSEGDQWLE-------NEKTKPLRPQQQPQCQPAGGTGQRRGSGSSPSADQQGAQDREE 69
Query: 456 ETSSAGSSREVGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLASRETSDSSEPEE 515
E ++A + GH+ Q + R PA + G + Q +++ + +
Sbjct: 70 EAAAAPAPTSRGHRTEKRKPQ-QPQRRPAGGTGQRRGSRSSSSADQQGAQDREEEAAAAP 128
Query: 516 APHTTDRRARRWRRARLGSEEPSKEPSSPSAQLRDLDTHQVSDDLSETDISNEARD---P 572
AP ++ R + + ++P P++ + Q R +D D EA P
Sbjct: 129 APTSSGHRTEKRK-----PQQPQCRPAAGTGQRRGSGCSPSADQQRAQDREEEATAAPVP 183
Query: 573 QTLTDTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESENQKESLSSEDNSQSVQEE 632
+ TE+++R +L + + S +P + ++ S SS Q ++
Sbjct: 184 TSSGHRTEKRKRLQLQCQPAGGTGQRRGSRSSPSRQPAGGTGQRRGSRSSPSADQQRAQD 243
Query: 633 LKKK 636
+++
Sbjct: 244 REEE 247
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 46.2 bits (108), Expect = 1e-04
Identities = 98/450 (21%), Positives = 170/450 (37%), Gaps = 75/450 (16%)
Query: 273 ADEGTSASPGGYRAPAALWRSQSAFSITGEEALKTPPVEAPSR--QPRDQGQHPRAESAL 330
+ E +S S A AL +++++ + A P E+P + P G+ A +
Sbjct: 265 SSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKA 324
Query: 331 PSWK-------SVDRLDETNLAPVLQSPDGNWVALKDGAPPPTRLLAKPKSGTFQALEVA 383
+ K S + D AP P G ++ + P P+ G A
Sbjct: 325 QAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKE---SPRKGAAPAPPRK 381
Query: 384 SSVASAYDEMG-------SDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPI 436
+ A+A ++G S SEE EAL+ + ++ P PQ A + GP+
Sbjct: 382 TGPAAAQVQVGKQEEDSRSSSEESDSDREALAAM-NAAQVKPLGKSPQVKPASTMGMGPL 440
Query: 437 A-------------ASPSSALSPNPEAMCSDSETSSAGSSREVG-------HQARLSWLQ 476
A+PS+ + E S SE SS S EV ++ + LQ
Sbjct: 441 GKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQ 500
Query: 477 RKAPRNPAAEKMRLHGELDVNFNPQL------ASRETSDSSEPEEAPHT-TDRRARRWRR 529
K +PA + G + V + +S E+SDS++ EEAP T +A+ +
Sbjct: 501 AKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALK 560
Query: 530 ARLGSEEPSKEPSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYE 589
P K ++ SA++ + + + T S P T
Sbjct: 561 IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQR--------- 611
Query: 590 LAMKMSEKETSSGEDQESEPKTESENQKESLS-SEDNSQSVQEELKKKFSAVSLCNISTE 648
ED S +++SE +K L+ + ++SV + L+ K ++V +
Sbjct: 612 -----------PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG---- 656
Query: 649 VLKVINATEELIAGSTGPWESPQVPPDRQK 678
+ T ++ G TGP + QV ++Q+
Sbjct: 657 --SLGQGTAPVLPGKTGPTVT-QVKAEKQE 683
Score = 38.5 bits (88), Expect = 0.027
Identities = 83/424 (19%), Positives = 156/424 (36%), Gaps = 56/424 (13%)
Query: 239 TILQKIIRKQKSK--SEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSA 296
T+ Q KQ+ SE++ + E P T V A+P RAP+A +
Sbjct: 673 TVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP 732
Query: 297 FSI--TGEEALKTPP--VEAPSRQPRDQGQHPRAESALPS-WKSVDRLDETNLAPVLQSP 351
+ +A + P V+ P R P++ R +++PS K+V + P +
Sbjct: 733 GKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP--EED 790
Query: 352 DGNWVALKDGAPPPTRLLAKPKSGTFQALEVA-----------------------SSVAS 388
G+ D L SG + A ++ A
Sbjct: 791 SGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAG 850
Query: 389 AYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALSPNP 448
D+ GS SEE EA + + P P + S GP AA+P+ A + +
Sbjct: 851 KQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNR---SPAGP-AATPAQAQAAST 906
Query: 449 EAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLASRET- 507
SE+++ SS E + + Q P +R + +P++A + +
Sbjct: 907 PRKARASESTARSSSSESEDEDVIPATQCLTP------GIRTNVVTMPTAHPRIAPKASM 960
Query: 508 SDSSEPEEAPHTTDRRARRWRRARLGSEEPSKEPSSPSA-QLRDLDTHQVSDDLSETDIS 566
+ +S +E+ +D + + ++ + P+ P + +A ++ + ++ T S
Sbjct: 961 AGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPS 1020
Query: 567 N---------EARDPQTLT---DTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESE 614
+ A PQ+ + T + R+ +L E+ E+S + S+ + SE
Sbjct: 1021 SGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSE 1080
Query: 615 NQKE 618
E
Sbjct: 1081 EDGE 1084
Score = 37.4 bits (85), Expect = 0.060
Identities = 82/355 (23%), Positives = 134/355 (37%), Gaps = 52/355 (14%)
Query: 293 SQSAFSITGEEALKTPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETNLA-PVLQSP 351
S A G+ A PP +A + + + P +S S +S D +ET A +LQ+
Sbjct: 227 SAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAK 286
Query: 352 DGNWVALKDGAPPPTRLLAKPKSGTFQA------LEVASSVASAYDEMGSDSEEDFDWSE 405
+ A P + P+ G A VA + A +E S E+ D E
Sbjct: 287 ASGKTSQVGAASAPAK--ESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEE 344
Query: 406 ALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSRE 465
++A P PQ A + P SP +P P +T A + +
Sbjct: 345 EAP-----AQAKPSGKAPQVRAASA----PAKESPRKGAAPAP-----PRKTGPAAAQVQ 390
Query: 466 VGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRAR 525
VG Q S R + +++ L P P+ P +T
Sbjct: 391 VGKQEEDS---RSSSEESDSDREALAAMNAAQVKPL--------GKSPQVKPASTMGMGP 439
Query: 526 RWRRARLGSEEPSK-EPSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRR 584
+ A G P K P++PSAQ+ + D S ++ S+++ D + T + +
Sbjct: 440 LGKGA--GPVPPGKVGPATPSAQVGKWE----EDSESSSEESSDSSDGEVPTAVAPAQEK 493
Query: 585 NRLYELAMKMSEKETSS---GEDQESEP---KTESENQKE-SLSSEDNSQSVQEE 632
+ L + K TSS G Q++ P + ++E + S SSE++S S E
Sbjct: 494 S----LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE 544
Score = 30.4 bits (67), Expect = 7.3
Identities = 81/447 (18%), Positives = 159/447 (35%), Gaps = 67/447 (14%)
Query: 246 RKQKSKSEQQVEEEPG-WPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSAFSITGEEA 304
+KQ+ + Q ++ P P Q+ +A + + A P P A R+Q + + + A
Sbjct: 976 KKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP-----PVA--RTQPSSGV--DSA 1026
Query: 305 LKTPPVEAP-SRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVALKDGAP 363
+ T P +P S + +G + + LP + + E++ S D + + +DG
Sbjct: 1027 VGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESS-DDSEDSSDSSSGSEEDGEG 1085
Query: 364 PP----TRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPR 419
P L P + L ++ S+ D++ + S+ S+A
Sbjct: 1086 PQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKA 1145
Query: 420 NPQPQPTQAQSSDQGPIAAS--PSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQR 477
P+ + + SS +AA P P+ + G G + S +
Sbjct: 1146 TPKLDSSPSVSST---LAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPK 1202
Query: 478 KAPRNPAAEKMRLHG--------------ELDVNFNPQLASRETSDSSEPEEAPHTTDRR 523
K NP A + L E V + E + + T +
Sbjct: 1203 KGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESS 1262
Query: 524 ARRW--RRARLGSEEPSKEPSSPSAQLRDLDTHQ-----VSDDLSETDISNEARDPQTLT 576
+ W R+ +L ++P+ + S + + L + VS + + T +A+ +
Sbjct: 1263 RKGWESRKRKLSGDQPAAR-TPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASG 1321
Query: 577 DTTEEKRRNRLYELAMK------------------------MSEKETSSGEDQESEPKTE 612
D E+K + L K EK+ S ++ E K +
Sbjct: 1322 DVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEK 1381
Query: 613 SENQKESLSSEDNSQSVQEELKKKFSA 639
+ K++ + + S S +++ KKK +A
Sbjct: 1382 KKKAKKASTKDSESPSQKKKKKKKKTA 1408
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 46.2 bits (108), Expect = 1e-04
Identities = 98/450 (21%), Positives = 170/450 (37%), Gaps = 75/450 (16%)
Query: 273 ADEGTSASPGGYRAPAALWRSQSAFSITGEEALKTPPVEAPSR--QPRDQGQHPRAESAL 330
+ E +S S A AL +++++ + A P E+P + P G+ A +
Sbjct: 342 SSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKA 401
Query: 331 PSWK-------SVDRLDETNLAPVLQSPDGNWVALKDGAPPPTRLLAKPKSGTFQALEVA 383
+ K S + D AP P G ++ + P P+ G A
Sbjct: 402 QAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKE---SPRKGAAPAPPRK 458
Query: 384 SSVASAYDEMG-------SDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPI 436
+ A+A ++G S SEE EAL+ + ++ P PQ A + GP+
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALAAM-NAAQVKPLGKSPQVKPASTMGMGPL 517
Query: 437 A-------------ASPSSALSPNPEAMCSDSETSSAGSSREVG-------HQARLSWLQ 476
A+PS+ + E S SE SS S EV ++ + LQ
Sbjct: 518 GKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQ 577
Query: 477 RKAPRNPAAEKMRLHGELDVNFNPQL------ASRETSDSSEPEEAPHT-TDRRARRWRR 529
K +PA + G + V + +S E+SDS++ EEAP T +A+ +
Sbjct: 578 AKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALK 637
Query: 530 ARLGSEEPSKEPSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYE 589
P K ++ SA++ + + + T S P T
Sbjct: 638 IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQR--------- 688
Query: 590 LAMKMSEKETSSGEDQESEPKTESENQKESLS-SEDNSQSVQEELKKKFSAVSLCNISTE 648
ED S +++SE +K L+ + ++SV + L+ K ++V +
Sbjct: 689 -----------PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG---- 733
Query: 649 VLKVINATEELIAGSTGPWESPQVPPDRQK 678
+ T ++ G TGP + QV ++Q+
Sbjct: 734 --SLGQGTAPVLPGKTGPTVT-QVKAEKQE 760
Score = 40.4 bits (93), Expect = 0.007
Identities = 89/393 (22%), Positives = 146/393 (37%), Gaps = 60/393 (15%)
Query: 263 PHPQSCSTKVADEGTSASPGGYRAPAALWR--------SQSAFSITGEEALKTPPVEAPS 314
P +S S++ E +P G R+ S A G+ A PP +A +
Sbjct: 266 PEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGA 325
Query: 315 RQPRDQGQHPRAESALPSWKSVDRLDETNLA-PVLQSPDGNWVALKDGAPPPTRLLAKPK 373
+ + P +S S +S D +ET A +LQ+ + A P + P+
Sbjct: 326 VASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAK--ESPR 383
Query: 374 SGTFQA------LEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQ 427
G A VA + A +E S E+ D E ++A P PQ
Sbjct: 384 KGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP-----AQAKPSGKAPQVRA 438
Query: 428 AQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAAEK 487
A + P SP +P P +T A + +VG Q S R + +++
Sbjct: 439 ASA----PAKESPRKGAAPAP-----PRKTGPAAAQVQVGKQEEDS---RSSSEESDSDR 486
Query: 488 MRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSK-EPSSPSA 546
L P P+ P +T + A G P K P++PSA
Sbjct: 487 EALAAMNAAQVKPL--------GKSPQVKPASTMGMGPLGKGA--GPVPPGKVGPATPSA 536
Query: 547 QLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSS---GE 603
Q+ + D S ++ S+++ D + T + ++ L + K TSS G
Sbjct: 537 QVGKWE----EDSESSSEESSDSSDGEVPTAVAPAQEKS----LGNILQAKPTSSPAKGP 588
Query: 604 DQESEP---KTESENQKE-SLSSEDNSQSVQEE 632
Q++ P + ++E + S SSE++S S E
Sbjct: 589 PQKAGPVAVQVKAEKPMDNSESSEESSDSADSE 621
Score = 37.7 bits (86), Expect = 0.046
Identities = 84/414 (20%), Positives = 139/414 (33%), Gaps = 74/414 (17%)
Query: 239 TILQKIIRKQKSK--SEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSA 296
T+ Q KQ+ SE++ + E P T V A+P RAP+A +
Sbjct: 750 TVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSA----KGT 805
Query: 297 FSITGEEALKTPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWV 356
S G+ + T +A R P + + P +++P + V
Sbjct: 806 ISAPGK--VVTAAAQAKQRSP------------------------SKVKPPVRNPQNSTV 839
Query: 357 ALKDGAPPPTRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCP---- 412
+ A P+ + K + QA + S E SDSEE+ +E L+++ P
Sbjct: 840 LARGPASVPS--VGKAVATAAQA-QTGPEEDSGSSEEESDSEEE---AETLAQVKPSGKT 893
Query: 413 ---RSRALPRNPQPQ----PTQAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSRE 465
R+ P P+ PT + A + E SD E +A +S +
Sbjct: 894 HQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ 953
Query: 466 VGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLA------SRETSDSSEPEEAPHT 519
V + ++P PAA + P+ A +R +S SE E+
Sbjct: 954 VIKPPLIFVDPNRSPAGPAATP----AQAQAASTPRKARASESTARSSSSESEDEDVIPA 1009
Query: 520 TD---------------RRARRWRRARLGSEEPSKEPSSPSAQLRDLDTHQVSDDLSETD 564
T R +A + SKE S S + D T
Sbjct: 1010 TQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTL 1069
Query: 565 ISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESENQKE 618
+ + T + R+ +L E+ E+S + S+ + SE E
Sbjct: 1070 PATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGE 1123
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 46.2 bits (108), Expect = 1e-04
Identities = 98/450 (21%), Positives = 170/450 (37%), Gaps = 75/450 (16%)
Query: 273 ADEGTSASPGGYRAPAALWRSQSAFSITGEEALKTPPVEAPSR--QPRDQGQHPRAESAL 330
+ E +S S A AL +++++ + A P E+P + P G+ A +
Sbjct: 342 SSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKA 401
Query: 331 PSWK-------SVDRLDETNLAPVLQSPDGNWVALKDGAPPPTRLLAKPKSGTFQALEVA 383
+ K S + D AP P G ++ + P P+ G A
Sbjct: 402 QAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKE---SPRKGAAPAPPRK 458
Query: 384 SSVASAYDEMG-------SDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPI 436
+ A+A ++G S SEE EAL+ + ++ P PQ A + GP+
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALAAM-NAAQVKPLGKSPQVKPASTMGMGPL 517
Query: 437 A-------------ASPSSALSPNPEAMCSDSETSSAGSSREVG-------HQARLSWLQ 476
A+PS+ + E S SE SS S EV ++ + LQ
Sbjct: 518 GKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQ 577
Query: 477 RKAPRNPAAEKMRLHGELDVNFNPQL------ASRETSDSSEPEEAPHT-TDRRARRWRR 529
K +PA + G + V + +S E+SDS++ EEAP T +A+ +
Sbjct: 578 AKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALK 637
Query: 530 ARLGSEEPSKEPSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYE 589
P K ++ SA++ + + + T S P T
Sbjct: 638 IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQR--------- 688
Query: 590 LAMKMSEKETSSGEDQESEPKTESENQKESLS-SEDNSQSVQEELKKKFSAVSLCNISTE 648
ED S +++SE +K L+ + ++SV + L+ K ++V +
Sbjct: 689 -----------PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG---- 733
Query: 649 VLKVINATEELIAGSTGPWESPQVPPDRQK 678
+ T ++ G TGP + QV ++Q+
Sbjct: 734 --SLGQGTAPVLPGKTGPTVT-QVKAEKQE 760
Score = 40.8 bits (94), Expect = 0.005
Identities = 89/476 (18%), Positives = 175/476 (36%), Gaps = 56/476 (11%)
Query: 239 TILQKIIRKQKSK--SEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSA 296
T+ Q KQ+ SE++ + E P T V A+P RAP+A +
Sbjct: 750 TVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP 809
Query: 297 FSI--TGEEALKTPP--VEAPSRQPRDQGQHPRAESALPS-WKSVDRLDETNLAPVLQSP 351
+ +A + P V+ P R P++ R +++PS K+V + P +
Sbjct: 810 GKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP--EED 867
Query: 352 DGNWVALKDGAPPPTRLLAKPKSGTFQALEVA-----------------------SSVAS 388
G+ D L SG + A ++ A
Sbjct: 868 SGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAG 927
Query: 389 AYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALSPNP 448
D+ GS SEE EA + + P P + S GP AA+P+ A + +
Sbjct: 928 KQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNR---SPAGP-AATPAQAQAAST 983
Query: 449 EAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLASRET- 507
SE+++ SS E + + Q P +R + +P++A + +
Sbjct: 984 PRKARASESTARSSSSESEDEDVIPATQCLTP------GIRTNVVTMPTAHPRIAPKASM 1037
Query: 508 SDSSEPEEAPHTTDRRARRWRRARLGSEEPSKEPSSPSA-QLRDLDTHQVSDDLSETDIS 566
+ +S +E+ +D + + ++ + P+ P + +A ++ + ++ T S
Sbjct: 1038 AGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPS 1097
Query: 567 N---------EARDPQTLT---DTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESE 614
+ A PQ+ + T + R+ +L E+ E+S + S+ + SE
Sbjct: 1098 SGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSE 1157
Query: 615 NQKESLSSEDNSQSVQEELKKKFSAVSLCNISTEVLKVINATEELIAGSTGPWESP 670
E ++ ++ + + V + V+ ++ L++G P +P
Sbjct: 1158 EDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTP 1213
Score = 40.4 bits (93), Expect = 0.007
Identities = 89/393 (22%), Positives = 146/393 (37%), Gaps = 60/393 (15%)
Query: 263 PHPQSCSTKVADEGTSASPGGYRAPAALWR--------SQSAFSITGEEALKTPPVEAPS 314
P +S S++ E +P G R+ S A G+ A PP +A +
Sbjct: 266 PEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGA 325
Query: 315 RQPRDQGQHPRAESALPSWKSVDRLDETNLA-PVLQSPDGNWVALKDGAPPPTRLLAKPK 373
+ + P +S S +S D +ET A +LQ+ + A P + P+
Sbjct: 326 VASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAK--ESPR 383
Query: 374 SGTFQA------LEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQ 427
G A VA + A +E S E+ D E ++A P PQ
Sbjct: 384 KGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP-----AQAKPSGKAPQVRA 438
Query: 428 AQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAAEK 487
A + P SP +P P +T A + +VG Q S R + +++
Sbjct: 439 ASA----PAKESPRKGAAPAP-----PRKTGPAAAQVQVGKQEEDS---RSSSEESDSDR 486
Query: 488 MRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSK-EPSSPSA 546
L P P+ P +T + A G P K P++PSA
Sbjct: 487 EALAAMNAAQVKPL--------GKSPQVKPASTMGMGPLGKGA--GPVPPGKVGPATPSA 536
Query: 547 QLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSS---GE 603
Q+ + D S ++ S+++ D + T + ++ L + K TSS G
Sbjct: 537 QVGKWE----EDSESSSEESSDSSDGEVPTAVAPAQEKS----LGNILQAKPTSSPAKGP 588
Query: 604 DQESEP---KTESENQKE-SLSSEDNSQSVQEE 632
Q++ P + ++E + S SSE++S S E
Sbjct: 589 PQKAGPVAVQVKAEKPMDNSESSEESSDSADSE 621
Score = 30.0 bits (66), Expect = 9.6
Identities = 85/442 (19%), Positives = 159/442 (35%), Gaps = 66/442 (14%)
Query: 246 RKQKSKSEQQVEEEPG-WPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSAFSITGEEA 304
+KQ+ + Q ++ P P Q+ +A + + A P P A R+Q + + + A
Sbjct: 1053 KKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP-----PVA--RTQPSSGV--DSA 1103
Query: 305 LKTPPVEAP-SRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVALKDGAP 363
+ T P +P S + +G + + LP + + E++ S D + + +DG
Sbjct: 1104 VGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESS-DDSEDSSDSSSGSEEDGEG 1162
Query: 364 PPTRLLAK---PKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRN 420
P A P + L ++ S+ D++ + S+ S+A
Sbjct: 1163 PQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKAT 1222
Query: 421 PQPQPTQAQSSDQGPIAAS--PSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRK 478
P+ + + SS +AA P P+ + G G + S +K
Sbjct: 1223 PKLDSSPSVSST---LAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKK 1279
Query: 479 APRNPAAEKMRLHG--------------ELDVNFNPQLASRETSDSSEPEEAPHTTDRRA 524
NP A + L E V + E + + T +
Sbjct: 1280 GAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSR 1339
Query: 525 RRW--RRARLGSEEPSKEPSSPSAQLRDLDTHQ-----VSDDLSETDISNEARDPQTLTD 577
+ W R+ +L ++P+ + S + + L + VS + + T +A+ + D
Sbjct: 1340 KGWESRKRKLSGDQPAAR-TPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGD 1398
Query: 578 TTEEKRRNRLYELAMKMSEKE-------TSSGEDQESEPKTESENQKESLSSED------ 624
E+K + L K +E T G DQ S PK++ E +K +D
Sbjct: 1399 VKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQ-SNPKSKKEKKKSDKRKKDKEKKEK 1457
Query: 625 ----------NSQSVQEELKKK 636
+S+S ++ KKK
Sbjct: 1458 KKKAKKASTKDSESPSQKKKKK 1479
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 46.2 bits (108), Expect = 1e-04
Identities = 98/450 (21%), Positives = 170/450 (37%), Gaps = 75/450 (16%)
Query: 273 ADEGTSASPGGYRAPAALWRSQSAFSITGEEALKTPPVEAPSR--QPRDQGQHPRAESAL 330
+ E +S S A AL +++++ + A P E+P + P G+ A +
Sbjct: 265 SSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKA 324
Query: 331 PSWK-------SVDRLDETNLAPVLQSPDGNWVALKDGAPPPTRLLAKPKSGTFQALEVA 383
+ K S + D AP P G ++ + P P+ G A
Sbjct: 325 QAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKE---SPRKGAAPAPPRK 381
Query: 384 SSVASAYDEMG-------SDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPI 436
+ A+A ++G S SEE EAL+ + ++ P PQ A + GP+
Sbjct: 382 TGPAAAQVQVGKQEEDSRSSSEESDSDREALAAM-NAAQVKPLGKSPQVKPASTMGMGPL 440
Query: 437 A-------------ASPSSALSPNPEAMCSDSETSSAGSSREVG-------HQARLSWLQ 476
A+PS+ + E S SE SS S EV ++ + LQ
Sbjct: 441 GKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQ 500
Query: 477 RKAPRNPAAEKMRLHGELDVNFNPQL------ASRETSDSSEPEEAPHT-TDRRARRWRR 529
K +PA + G + V + +S E+SDS++ EEAP T +A+ +
Sbjct: 501 AKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALK 560
Query: 530 ARLGSEEPSKEPSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYE 589
P K ++ SA++ + + + T S P T
Sbjct: 561 IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQR--------- 611
Query: 590 LAMKMSEKETSSGEDQESEPKTESENQKESLS-SEDNSQSVQEELKKKFSAVSLCNISTE 648
ED S +++SE +K L+ + ++SV + L+ K ++V +
Sbjct: 612 -----------PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG---- 656
Query: 649 VLKVINATEELIAGSTGPWESPQVPPDRQK 678
+ T ++ G TGP + QV ++Q+
Sbjct: 657 --SLGQGTAPVLPGKTGPTVT-QVKAEKQE 683
Score = 40.8 bits (94), Expect = 0.005
Identities = 89/476 (18%), Positives = 175/476 (36%), Gaps = 56/476 (11%)
Query: 239 TILQKIIRKQKSK--SEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSA 296
T+ Q KQ+ SE++ + E P T V A+P RAP+A +
Sbjct: 673 TVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP 732
Query: 297 FSI--TGEEALKTPP--VEAPSRQPRDQGQHPRAESALPS-WKSVDRLDETNLAPVLQSP 351
+ +A + P V+ P R P++ R +++PS K+V + P +
Sbjct: 733 GKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP--EED 790
Query: 352 DGNWVALKDGAPPPTRLLAKPKSGTFQALEVA-----------------------SSVAS 388
G+ D L SG + A ++ A
Sbjct: 791 SGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAG 850
Query: 389 AYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALSPNP 448
D+ GS SEE EA + + P P + S GP AA+P+ A + +
Sbjct: 851 KQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNR---SPAGP-AATPAQAQAAST 906
Query: 449 EAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLASRET- 507
SE+++ SS E + + Q P +R + +P++A + +
Sbjct: 907 PRKARASESTARSSSSESEDEDVIPATQCLTP------GIRTNVVTMPTAHPRIAPKASM 960
Query: 508 SDSSEPEEAPHTTDRRARRWRRARLGSEEPSKEPSSPSA-QLRDLDTHQVSDDLSETDIS 566
+ +S +E+ +D + + ++ + P+ P + +A ++ + ++ T S
Sbjct: 961 AGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPS 1020
Query: 567 N---------EARDPQTLT---DTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESE 614
+ A PQ+ + T + R+ +L E+ E+S + S+ + SE
Sbjct: 1021 SGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSE 1080
Query: 615 NQKESLSSEDNSQSVQEELKKKFSAVSLCNISTEVLKVINATEELIAGSTGPWESP 670
E ++ ++ + + V + V+ ++ L++G P +P
Sbjct: 1081 EDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTP 1136
Score = 37.4 bits (85), Expect = 0.060
Identities = 82/355 (23%), Positives = 134/355 (37%), Gaps = 52/355 (14%)
Query: 293 SQSAFSITGEEALKTPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETNLA-PVLQSP 351
S A G+ A PP +A + + + P +S S +S D +ET A +LQ+
Sbjct: 227 SAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAK 286
Query: 352 DGNWVALKDGAPPPTRLLAKPKSGTFQA------LEVASSVASAYDEMGSDSEEDFDWSE 405
+ A P + P+ G A VA + A +E S E+ D E
Sbjct: 287 ASGKTSQVGAASAPAK--ESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEE 344
Query: 406 ALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSRE 465
++A P PQ A + P SP +P P +T A + +
Sbjct: 345 EAP-----AQAKPSGKAPQVRAASA----PAKESPRKGAAPAP-----PRKTGPAAAQVQ 390
Query: 466 VGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRAR 525
VG Q S R + +++ L P P+ P +T
Sbjct: 391 VGKQEEDS---RSSSEESDSDREALAAMNAAQVKPL--------GKSPQVKPASTMGMGP 439
Query: 526 RWRRARLGSEEPSK-EPSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRR 584
+ A G P K P++PSAQ+ + D S ++ S+++ D + T + +
Sbjct: 440 LGKGA--GPVPPGKVGPATPSAQVGKWE----EDSESSSEESSDSSDGEVPTAVAPAQEK 493
Query: 585 NRLYELAMKMSEKETSS---GEDQESEP---KTESENQKE-SLSSEDNSQSVQEE 632
+ L + K TSS G Q++ P + ++E + S SSE++S S E
Sbjct: 494 S----LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE 544
Score = 30.0 bits (66), Expect = 9.6
Identities = 85/442 (19%), Positives = 159/442 (35%), Gaps = 66/442 (14%)
Query: 246 RKQKSKSEQQVEEEPG-WPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSAFSITGEEA 304
+KQ+ + Q ++ P P Q+ +A + + A P P A R+Q + + + A
Sbjct: 976 KKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP-----PVA--RTQPSSGV--DSA 1026
Query: 305 LKTPPVEAP-SRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVALKDGAP 363
+ T P +P S + +G + + LP + + E++ S D + + +DG
Sbjct: 1027 VGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESS-DDSEDSSDSSSGSEEDGEG 1085
Query: 364 PPTRLLAK---PKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRN 420
P A P + L ++ S+ D++ + S+ S+A
Sbjct: 1086 PQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKAT 1145
Query: 421 PQPQPTQAQSSDQGPIAAS--PSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRK 478
P+ + + SS +AA P P+ + G G + S +K
Sbjct: 1146 PKLDSSPSVSST---LAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKK 1202
Query: 479 APRNPAAEKMRLHG--------------ELDVNFNPQLASRETSDSSEPEEAPHTTDRRA 524
NP A + L E V + E + + T +
Sbjct: 1203 GAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSR 1262
Query: 525 RRW--RRARLGSEEPSKEPSSPSAQLRDLDTHQ-----VSDDLSETDISNEARDPQTLTD 577
+ W R+ +L ++P+ + S + + L + VS + + T +A+ + D
Sbjct: 1263 KGWESRKRKLSGDQPAAR-TPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGD 1321
Query: 578 TTEEKRRNRLYELAMKMSEKE-------TSSGEDQESEPKTESENQKESLSSED------ 624
E+K + L K +E T G DQ S PK++ E +K +D
Sbjct: 1322 VKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQ-SNPKSKKEKKKSDKRKKDKEKKEK 1380
Query: 625 ----------NSQSVQEELKKK 636
+S+S ++ KKK
Sbjct: 1381 KKKAKKASTKDSESPSQKKKKK 1402
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 46.2 bits (108), Expect = 1e-04
Identities = 98/450 (21%), Positives = 170/450 (37%), Gaps = 75/450 (16%)
Query: 273 ADEGTSASPGGYRAPAALWRSQSAFSITGEEALKTPPVEAPSR--QPRDQGQHPRAESAL 330
+ E +S S A AL +++++ + A P E+P + P G+ A +
Sbjct: 342 SSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKA 401
Query: 331 PSWK-------SVDRLDETNLAPVLQSPDGNWVALKDGAPPPTRLLAKPKSGTFQALEVA 383
+ K S + D AP P G ++ + P P+ G A
Sbjct: 402 QAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKE---SPRKGAAPAPPRK 458
Query: 384 SSVASAYDEMG-------SDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPI 436
+ A+A ++G S SEE EAL+ + ++ P PQ A + GP+
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALAAM-NAAQVKPLGKSPQVKPASTMGMGPL 517
Query: 437 A-------------ASPSSALSPNPEAMCSDSETSSAGSSREVG-------HQARLSWLQ 476
A+PS+ + E S SE SS S EV ++ + LQ
Sbjct: 518 GKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQ 577
Query: 477 RKAPRNPAAEKMRLHGELDVNFNPQL------ASRETSDSSEPEEAPHT-TDRRARRWRR 529
K +PA + G + V + +S E+SDS++ EEAP T +A+ +
Sbjct: 578 AKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALK 637
Query: 530 ARLGSEEPSKEPSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYE 589
P K ++ SA++ + + + T S P T
Sbjct: 638 IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQR--------- 688
Query: 590 LAMKMSEKETSSGEDQESEPKTESENQKESLS-SEDNSQSVQEELKKKFSAVSLCNISTE 648
ED S +++SE +K L+ + ++SV + L+ K ++V +
Sbjct: 689 -----------PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG---- 733
Query: 649 VLKVINATEELIAGSTGPWESPQVPPDRQK 678
+ T ++ G TGP + QV ++Q+
Sbjct: 734 --SLGQGTAPVLPGKTGPTVT-QVKAEKQE 760
Score = 40.4 bits (93), Expect = 0.007
Identities = 89/393 (22%), Positives = 146/393 (37%), Gaps = 60/393 (15%)
Query: 263 PHPQSCSTKVADEGTSASPGGYRAPAALWR--------SQSAFSITGEEALKTPPVEAPS 314
P +S S++ E +P G R+ S A G+ A PP +A +
Sbjct: 266 PEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGA 325
Query: 315 RQPRDQGQHPRAESALPSWKSVDRLDETNLA-PVLQSPDGNWVALKDGAPPPTRLLAKPK 373
+ + P +S S +S D +ET A +LQ+ + A P + P+
Sbjct: 326 VASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAK--ESPR 383
Query: 374 SGTFQA------LEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQ 427
G A VA + A +E S E+ D E ++A P PQ
Sbjct: 384 KGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP-----AQAKPSGKAPQVRA 438
Query: 428 AQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAAEK 487
A + P SP +P P +T A + +VG Q S R + +++
Sbjct: 439 ASA----PAKESPRKGAAPAP-----PRKTGPAAAQVQVGKQEEDS---RSSSEESDSDR 486
Query: 488 MRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSK-EPSSPSA 546
L P P+ P +T + A G P K P++PSA
Sbjct: 487 EALAAMNAAQVKPL--------GKSPQVKPASTMGMGPLGKGA--GPVPPGKVGPATPSA 536
Query: 547 QLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSS---GE 603
Q+ + D S ++ S+++ D + T + ++ L + K TSS G
Sbjct: 537 QVGKWE----EDSESSSEESSDSSDGEVPTAVAPAQEKS----LGNILQAKPTSSPAKGP 588
Query: 604 DQESEP---KTESENQKE-SLSSEDNSQSVQEE 632
Q++ P + ++E + S SSE++S S E
Sbjct: 589 PQKAGPVAVQVKAEKPMDNSESSEESSDSADSE 621
Score = 40.0 bits (92), Expect = 0.009
Identities = 90/466 (19%), Positives = 158/466 (33%), Gaps = 74/466 (15%)
Query: 239 TILQKIIRKQKSK--SEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSA 296
T+ Q KQ+ SE++ + E P T V A+P RAP+A +
Sbjct: 750 TVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSA----KGT 805
Query: 297 FSITGEEALKTPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWV 356
S G+ + T +A R P + + P +++P + V
Sbjct: 806 ISAPGK--VVTAAAQAKQRSP------------------------SKVKPPVRNPQNSTV 839
Query: 357 ALKDGAPPPTRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCP---- 412
+ A P+ + K + QA + S E SDSEE+ +E L+++ P
Sbjct: 840 LARGPASVPS--VGKAVATAAQA-QTGPEEDSGSSEEESDSEEE---AETLAQVKPSGKT 893
Query: 413 ---RSRALPRNPQPQ----PTQAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSRE 465
R+ P P+ PT + A + E SD E +A +S +
Sbjct: 894 HQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ 953
Query: 466 VGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLA------SRETSDSSEPEEAPHT 519
V + ++P PAA + P+ A +R +S SE E+
Sbjct: 954 VIKPPLIFVDPNRSPAGPAATP----AQAQAASTPRKARASESTARSSSSESEDEDVIPA 1009
Query: 520 TD---------------RRARRWRRARLGSEEPSKEPSSPSAQLRDLDTHQVSDDLSETD 564
T R +A + SKE S S + D T
Sbjct: 1010 TQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTL 1069
Query: 565 ISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESENQKESLSSED 624
+ + T + R+ +L E+ E+S + S+ + SE E
Sbjct: 1070 PATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAK 1129
Query: 625 NSQSVQEELKKKFSAVSLCNISTEVLKVINATEELIAGSTGPWESP 670
++ ++ + + V + V+ ++ L++G P +P
Sbjct: 1130 SAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTP 1175
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 46.2 bits (108), Expect = 1e-04
Identities = 98/450 (21%), Positives = 170/450 (37%), Gaps = 75/450 (16%)
Query: 273 ADEGTSASPGGYRAPAALWRSQSAFSITGEEALKTPPVEAPSR--QPRDQGQHPRAESAL 330
+ E +S S A AL +++++ + A P E+P + P G+ A +
Sbjct: 342 SSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKA 401
Query: 331 PSWK-------SVDRLDETNLAPVLQSPDGNWVALKDGAPPPTRLLAKPKSGTFQALEVA 383
+ K S + D AP P G ++ + P P+ G A
Sbjct: 402 QAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKE---SPRKGAAPAPPRK 458
Query: 384 SSVASAYDEMG-------SDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPI 436
+ A+A ++G S SEE EAL+ + ++ P PQ A + GP+
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALAAM-NAAQVKPLGKSPQVKPASTMGMGPL 517
Query: 437 A-------------ASPSSALSPNPEAMCSDSETSSAGSSREVG-------HQARLSWLQ 476
A+PS+ + E S SE SS S EV ++ + LQ
Sbjct: 518 GKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQ 577
Query: 477 RKAPRNPAAEKMRLHGELDVNFNPQL------ASRETSDSSEPEEAPHT-TDRRARRWRR 529
K +PA + G + V + +S E+SDS++ EEAP T +A+ +
Sbjct: 578 AKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALK 637
Query: 530 ARLGSEEPSKEPSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYE 589
P K ++ SA++ + + + T S P T
Sbjct: 638 IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQR--------- 688
Query: 590 LAMKMSEKETSSGEDQESEPKTESENQKESLS-SEDNSQSVQEELKKKFSAVSLCNISTE 648
ED S +++SE +K L+ + ++SV + L+ K ++V +
Sbjct: 689 -----------PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG---- 733
Query: 649 VLKVINATEELIAGSTGPWESPQVPPDRQK 678
+ T ++ G TGP + QV ++Q+
Sbjct: 734 --SLGQGTAPVLPGKTGPTVT-QVKAEKQE 760
Score = 40.4 bits (93), Expect = 0.007
Identities = 89/393 (22%), Positives = 146/393 (37%), Gaps = 60/393 (15%)
Query: 263 PHPQSCSTKVADEGTSASPGGYRAPAALWR--------SQSAFSITGEEALKTPPVEAPS 314
P +S S++ E +P G R+ S A G+ A PP +A +
Sbjct: 266 PEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGA 325
Query: 315 RQPRDQGQHPRAESALPSWKSVDRLDETNLA-PVLQSPDGNWVALKDGAPPPTRLLAKPK 373
+ + P +S S +S D +ET A +LQ+ + A P + P+
Sbjct: 326 VASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAK--ESPR 383
Query: 374 SGTFQA------LEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQ 427
G A VA + A +E S E+ D E ++A P PQ
Sbjct: 384 KGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP-----AQAKPSGKAPQVRA 438
Query: 428 AQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAAEK 487
A + P SP +P P +T A + +VG Q S R + +++
Sbjct: 439 ASA----PAKESPRKGAAPAP-----PRKTGPAAAQVQVGKQEEDS---RSSSEESDSDR 486
Query: 488 MRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSK-EPSSPSA 546
L P P+ P +T + A G P K P++PSA
Sbjct: 487 EALAAMNAAQVKPL--------GKSPQVKPASTMGMGPLGKGA--GPVPPGKVGPATPSA 536
Query: 547 QLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSS---GE 603
Q+ + D S ++ S+++ D + T + ++ L + K TSS G
Sbjct: 537 QVGKWE----EDSESSSEESSDSSDGEVPTAVAPAQEKS----LGNILQAKPTSSPAKGP 588
Query: 604 DQESEP---KTESENQKE-SLSSEDNSQSVQEE 632
Q++ P + ++E + S SSE++S S E
Sbjct: 589 PQKAGPVAVQVKAEKPMDNSESSEESSDSADSE 621
Score = 33.1 bits (74), Expect = 1.1
Identities = 50/229 (21%), Positives = 85/229 (37%), Gaps = 42/229 (18%)
Query: 239 TILQKIIRKQKSK--SEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSA 296
T+ Q KQ+ SE++ + E P T V A+P RAP+A +
Sbjct: 750 TVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSA----KGT 805
Query: 297 FSITGEEALKTPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWV 356
S G+ + T +A R P + + P +++P + V
Sbjct: 806 ISAPGK--VVTAAAQAKQRSP------------------------SKVKPPVRNPQNSTV 839
Query: 357 ALKDGAPPPTRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRA 416
+ A P+ + K + QA + S E SDSEE+ +E L+++ P
Sbjct: 840 LARGPASVPS--VGKAVATAAQA-QTGPEEDSGSSEEESDSEEE---AETLAQVKPSG-- 891
Query: 417 LPRNPQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSRE 465
+ Q + A + + A+P+ P A + + S SS E
Sbjct: 892 --KTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEE 938
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,385,348
Number of Sequences: 37866
Number of extensions: 1721586
Number of successful extensions: 11992
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 115
Number of HSP's successfully gapped in prelim test: 662
Number of HSP's that attempted gapping in prelim test: 9868
Number of HSP's gapped (non-prelim): 2433
length of query: 859
length of database: 18,247,518
effective HSP length: 111
effective length of query: 748
effective length of database: 14,044,392
effective search space: 10505205216
effective search space used: 10505205216
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.