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Search of human proteins with 5901892
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform
1 [Homo sapiens]
(1129 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1... 2293 0.0
gi|56550086 WD repeat and HMG-box DNA binding protein 1 isoform ... 2040 0.0
gi|16554629 WD repeat domain 5 [Homo sapiens] 78 4e-14
gi|16554627 WD repeat domain 5 [Homo sapiens] 78 4e-14
gi|23199987 WD repeat domain 5B [Homo sapiens] 73 2e-12
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens] 71 5e-12
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens] 71 5e-12
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 64 1e-09
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 63 1e-09
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 63 1e-09
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 63 1e-09
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 63 1e-09
gi|4757988 WD repeat domain 39 [Homo sapiens] 62 3e-09
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 61 5e-09
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 61 7e-09
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 61 7e-09
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 61 7e-09
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 61 7e-09
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 61 7e-09
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 61 7e-09
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 61 7e-09
gi|19913367 transducin beta-like 1Y [Homo sapiens] 60 9e-09
gi|19913365 transducin beta-like 1Y [Homo sapiens] 60 9e-09
gi|15150805 transducin beta-like 1Y [Homo sapiens] 60 9e-09
gi|26665869 WD repeat domain 51B [Homo sapiens] 60 1e-08
gi|32189425 WD repeat domain 69 [Homo sapiens] 60 2e-08
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 60 2e-08
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 59 2e-08
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 58 6e-08
gi|21071067 TBP-associated factor 5 [Homo sapiens] 58 6e-08
>gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1
[Homo sapiens]
Length = 1129
Score = 2293 bits (5942), Expect = 0.0
Identities = 1129/1129 (100%), Positives = 1129/1129 (100%)
Query: 1 MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSC 60
MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSC
Sbjct: 1 MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSC 60
Query: 61 ALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKI 120
ALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKI
Sbjct: 61 ALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKI 120
Query: 121 VDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKC 180
VDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKC
Sbjct: 121 VDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKC 180
Query: 181 NDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSP 240
NDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSP
Sbjct: 181 NDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSP 240
Query: 241 CGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLL 300
CGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLL
Sbjct: 241 CGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLL 300
Query: 301 ENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDD 360
ENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDD
Sbjct: 301 ENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDD 360
Query: 361 EDLMMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPF 420
EDLMMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPF
Sbjct: 361 EDLMMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPF 420
Query: 421 YDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATH 480
YDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATH
Sbjct: 421 YDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATH 480
Query: 481 LSNTLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICL 540
LSNTLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICL
Sbjct: 481 LSNTLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICL 540
Query: 541 GQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLG 600
GQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLG
Sbjct: 541 GQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLG 600
Query: 601 VQLLELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTP 660
VQLLELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTP
Sbjct: 601 VQLLELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTP 660
Query: 661 ICNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIAT 720
ICNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIAT
Sbjct: 661 ICNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIAT 720
Query: 721 EKGQMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFR 780
EKGQMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFR
Sbjct: 721 EKGQMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFR 780
Query: 781 CVELADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKK 840
CVELADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKK
Sbjct: 781 CVELADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKK 840
Query: 841 LNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKS 900
LNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKS
Sbjct: 841 LNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKS 900
Query: 901 GAVTFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPI 960
GAVTFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPI
Sbjct: 901 GAVTFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPI 960
Query: 961 IKPLIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKT 1020
IKPLIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKT
Sbjct: 961 IKPLIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKT 1020
Query: 1021 GFQMWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEA 1080
GFQMWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEA
Sbjct: 1021 GFQMWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEA 1080
Query: 1081 KKRKRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE 1129
KKRKRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE
Sbjct: 1081 KKRKRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE 1129
>gi|56550086 WD repeat and HMG-box DNA binding protein 1 isoform 2
[Homo sapiens]
Length = 1006
Score = 2040 bits (5285), Expect = 0.0
Identities = 1006/1006 (100%), Positives = 1006/1006 (100%)
Query: 124 MDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDV 183
MDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDV
Sbjct: 1 MDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDV 60
Query: 184 INAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQ 243
INAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQ
Sbjct: 61 INAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQ 120
Query: 244 YLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLLENV 303
YLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLLENV
Sbjct: 121 YLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLLENV 180
Query: 304 CDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDDEDL 363
CDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDDEDL
Sbjct: 181 CDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDDEDL 240
Query: 364 MMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPFYDG 423
MMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPFYDG
Sbjct: 241 MMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPFYDG 300
Query: 424 PMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATHLSN 483
PMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATHLSN
Sbjct: 301 PMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATHLSN 360
Query: 484 TLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICLGQG 543
TLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICLGQG
Sbjct: 361 TLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICLGQG 420
Query: 544 WAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLGVQL 603
WAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLGVQL
Sbjct: 421 WAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLGVQL 480
Query: 604 LELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTPICN 663
LELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTPICN
Sbjct: 481 LELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTPICN 540
Query: 664 TREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIATEKG 723
TREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIATEKG
Sbjct: 541 TREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIATEKG 600
Query: 724 QMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFRCVE 783
QMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFRCVE
Sbjct: 601 QMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFRCVE 660
Query: 784 LADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKKLNA 843
LADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKKLNA
Sbjct: 661 LADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKKLNA 720
Query: 844 GYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKSGAV 903
GYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKSGAV
Sbjct: 721 GYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKSGAV 780
Query: 904 TFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPIIKP 963
TFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPIIKP
Sbjct: 781 TFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPIIKP 840
Query: 964 LIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKTGFQ 1023
LIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKTGFQ
Sbjct: 841 LIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKTGFQ 900
Query: 1024 MWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEAKKR 1083
MWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEAKKR
Sbjct: 901 MWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEAKKR 960
Query: 1084 KRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE 1129
KRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE
Sbjct: 961 KRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE 1006
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 78.2 bits (191), Expect = 4e-14
Identities = 66/281 (23%), Positives = 127/281 (45%), Gaps = 18/281 (6%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFIN---VGEKAYSCALKSGKL 67
GHT+ + V F +G ++ + +D ++IW D K I+ +G + + S L
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
Query: 68 VTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVV---FNGDGTKIAAGSSDFLVKIVDVM 124
V+A + T+++ G L ++N+V FN I +GS D V+I DV
Sbjct: 103 VSASDDKTLKIWDVSSGK---CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 125 DSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVI 184
KT H PV ++ F+ + S+S DG R+W + C + L+ N +
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKT--LIDDDNPPV 217
Query: 185 NAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCG-Q 243
+ + + P +LA ++ ++KL+ + + + +S G +
Sbjct: 218 SF-----VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 272
Query: 244 YLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPT 284
++ +GS + L+ +WN++TK+ +++++ I A HPT
Sbjct: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI-STACHPT 312
Score = 55.5 bits (132), Expect = 3e-07
Identities = 40/177 (22%), Positives = 83/177 (46%), Gaps = 10/177 (5%)
Query: 90 LTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDI 149
L T + V F+ +G +A+ S+D L+KI D +KT GH + +++
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 150 FLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKS 209
L SAS D ++++W +S C L+ N C + P+S +++ ++S
Sbjct: 101 LLVSASDDKTLKIWDVSSGKC------LKTLKGHSNYVFCCN--FNPQSNLIVSGSFDES 152
Query: 210 VKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCME 266
V+++ ++ L + S ++ V ++ G + + S +GL +W+ + C++
Sbjct: 153 VRIWDVKTGKCLKTLPAH--SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207
Score = 47.8 bits (112), Expect = 6e-05
Identities = 45/171 (26%), Positives = 82/171 (47%), Gaps = 27/171 (15%)
Query: 12 HTEGHTEVCFDDSGSFIVTCGSDGDVRIWED---------LDDDDPKFINVGEKAYSCAL 62
H++ + V F+ GS IV+ DG RIW+ +DDD+P ++
Sbjct: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV------SFVKFS 223
Query: 63 KSGKLVTAVS-NNTIQVHTFPEGVPDGILTRFTTNANHVV-----FNGDGTK-IAAGSSD 115
+GK + A + +NT+++ + +G L +T + N F+ G K I +GS D
Sbjct: 224 PNGKYILAATLDNTLKLWDYSKGK---CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 280
Query: 116 FLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASC--DGSVRVWQ 164
LV I ++ + +GH V+S + P + +ASA+ D ++++W+
Sbjct: 281 NLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 44.3 bits (103), Expect = 7e-04
Identities = 33/138 (23%), Positives = 61/138 (44%), Gaps = 14/138 (10%)
Query: 131 TFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAK--S 188
T GH V S+ F P +LAS+S D +++W D K I+
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD----------GKFEKTISGHKLG 89
Query: 189 ICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAG 248
I +AW S L++ +K++K++ S L + S + ++P + +G
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH--SNYVFCCNFNPQSNLIVSG 147
Query: 249 SINGLIIVWNVETKDCME 266
S + + +W+V+T C++
Sbjct: 148 SFDESVRIWDVKTGKCLK 165
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 78.2 bits (191), Expect = 4e-14
Identities = 66/281 (23%), Positives = 127/281 (45%), Gaps = 18/281 (6%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFIN---VGEKAYSCALKSGKL 67
GHT+ + V F +G ++ + +D ++IW D K I+ +G + + S L
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
Query: 68 VTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVV---FNGDGTKIAAGSSDFLVKIVDVM 124
V+A + T+++ G L ++N+V FN I +GS D V+I DV
Sbjct: 103 VSASDDKTLKIWDVSSGK---CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 125 DSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVI 184
KT H PV ++ F+ + S+S DG R+W + C + L+ N +
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKT--LIDDDNPPV 217
Query: 185 NAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCG-Q 243
+ + + P +LA ++ ++KL+ + + + +S G +
Sbjct: 218 SF-----VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 272
Query: 244 YLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPT 284
++ +GS + L+ +WN++TK+ +++++ I A HPT
Sbjct: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI-STACHPT 312
Score = 55.5 bits (132), Expect = 3e-07
Identities = 40/177 (22%), Positives = 83/177 (46%), Gaps = 10/177 (5%)
Query: 90 LTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDI 149
L T + V F+ +G +A+ S+D L+KI D +KT GH + +++
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 150 FLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKS 209
L SAS D ++++W +S C L+ N C + P+S +++ ++S
Sbjct: 101 LLVSASDDKTLKIWDVSSGKC------LKTLKGHSNYVFCCN--FNPQSNLIVSGSFDES 152
Query: 210 VKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCME 266
V+++ ++ L + S ++ V ++ G + + S +GL +W+ + C++
Sbjct: 153 VRIWDVKTGKCLKTLPAH--SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207
Score = 47.8 bits (112), Expect = 6e-05
Identities = 45/171 (26%), Positives = 82/171 (47%), Gaps = 27/171 (15%)
Query: 12 HTEGHTEVCFDDSGSFIVTCGSDGDVRIWED---------LDDDDPKFINVGEKAYSCAL 62
H++ + V F+ GS IV+ DG RIW+ +DDD+P ++
Sbjct: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV------SFVKFS 223
Query: 63 KSGKLVTAVS-NNTIQVHTFPEGVPDGILTRFTTNANHVV-----FNGDGTK-IAAGSSD 115
+GK + A + +NT+++ + +G L +T + N F+ G K I +GS D
Sbjct: 224 PNGKYILAATLDNTLKLWDYSKGK---CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 280
Query: 116 FLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASC--DGSVRVWQ 164
LV I ++ + +GH V+S + P + +ASA+ D ++++W+
Sbjct: 281 NLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 44.3 bits (103), Expect = 7e-04
Identities = 33/138 (23%), Positives = 61/138 (44%), Gaps = 14/138 (10%)
Query: 131 TFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAK--S 188
T GH V S+ F P +LAS+S D +++W D K I+
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD----------GKFEKTISGHKLG 89
Query: 189 ICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAG 248
I +AW S L++ +K++K++ S L + S + ++P + +G
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH--SNYVFCCNFNPQSNLIVSG 147
Query: 249 SINGLIIVWNVETKDCME 266
S + + +W+V+T C++
Sbjct: 148 SFDESVRIWDVKTGKCLK 165
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 72.8 bits (177), Expect = 2e-12
Identities = 66/283 (23%), Positives = 125/283 (44%), Gaps = 22/283 (7%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFI-----NVGEKAYSCALKSG 65
GHTE + V F +G ++ + +D + IW D K + + + A+S S
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSS--DSS 96
Query: 66 KLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVV---FNGDGTKIAAGSSDFLVKIVD 122
+LV+A + T+++ G L ++N+V FN I +GS D VKI +
Sbjct: 97 RLVSASDDKTLKLWDVRSGK---CLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
Query: 123 VMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCND 182
V KT H PV ++ F+ + S S DG R+W + C + L+ N
Sbjct: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKT--LVDDDNP 211
Query: 183 VINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCG 242
++ + + P +L ++ ++KL+ + + + +S G
Sbjct: 212 PVSF-----VKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTG 266
Query: 243 -QYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPT 284
+++ +GS + L+ +WN++TK+ +++++ I A HPT
Sbjct: 267 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI-SAACHPT 308
Score = 57.0 bits (136), Expect = 1e-07
Identities = 46/207 (22%), Positives = 94/207 (45%), Gaps = 13/207 (6%)
Query: 63 KSGKLVTAVSNNTIQVHTFPEGVPDGI---LTRFTTNANHVVFNGDGTKIAAGSSDFLVK 119
+ K A+S++ Q PE + L T + V F+ +G +A+ S+D L+
Sbjct: 7 RDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLII 66
Query: 120 IVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQK 179
I D +KT GH+ + +++ L SAS D ++++W + C L+
Sbjct: 67 IWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKC------LKT 120
Query: 180 CNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWS 239
N C + P S +++ +++VK++ ++ LS + S ++ V ++
Sbjct: 121 LKGHSNYVFCCN--FNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAH--SDPVSAVHFN 176
Query: 240 PCGQYLAAGSINGLIIVWNVETKDCME 266
G + +GS +GL +W+ + C++
Sbjct: 177 CSGSLIVSGSYDGLCRIWDAASGQCLK 203
Score = 48.1 bits (113), Expect = 5e-05
Identities = 47/170 (27%), Positives = 82/170 (48%), Gaps = 27/170 (15%)
Query: 12 HTEGHTEVCFDDSGSFIVTCGSDGDVRIWED---------LDDDDPKFINVGEKAYSCAL 62
H++ + V F+ SGS IV+ DG RIW+ +DDD+P ++
Sbjct: 166 HSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV------SFVKFS 219
Query: 63 KSGK-LVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVV-----FNGDGTK-IAAGSSD 115
+GK ++TA +NT+++ + G L +T + N F+ G K I +GS D
Sbjct: 220 PNGKYILTATLDNTLKLWDYSRG---RCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 276
Query: 116 FLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASC--DGSVRVW 163
LV I ++ + +GH V+S + P + +ASA+ D ++++W
Sbjct: 277 NLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
Length = 607
Score = 71.2 bits (173), Expect = 5e-12
Identities = 75/325 (23%), Positives = 120/325 (36%), Gaps = 71/325 (21%)
Query: 1 MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSC 60
+PAT + H V F + T G D V++WE GEK C
Sbjct: 310 VPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVF----------GEK---C 356
Query: 61 ALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKI 120
K G L+ + F+ G+ + A S+DF +I
Sbjct: 357 EFK------------------------GSLSGSNAGITSIEFDSAGSYLLAASNDFASRI 392
Query: 121 VDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKC 180
V D + T GH VLS F + + S S D ++++W + + C + C
Sbjct: 393 WTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSC 452
Query: 181 NDVINAKSICRLA---------WQPKS----------GKLLAI---PVEKSVKLYRRESW 218
ND++ + C ++ W +S GK+ A+ P + R+
Sbjct: 453 NDIVCTEQ-CVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRDDL 511
Query: 219 SHQFDLSDNFISQTLNI-----------VTWSPCGQYLAAGSINGLIIVWNVETKDCMER 267
DL N I QT + V +SP G Y+AAGS G + +W+V T +
Sbjct: 512 LKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKV 571
Query: 268 VKHEKGYAICGLAWHPTCGRISYTD 292
+ + +I +AW P+ + D
Sbjct: 572 LSKQHSSSINAVAWSPSGSHVVSVD 596
>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
Length = 588
Score = 71.2 bits (173), Expect = 5e-12
Identities = 75/325 (23%), Positives = 120/325 (36%), Gaps = 71/325 (21%)
Query: 1 MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSC 60
+PAT + H V F + T G D V++WE GEK C
Sbjct: 291 VPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVF----------GEK---C 337
Query: 61 ALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKI 120
K G L+ + F+ G+ + A S+DF +I
Sbjct: 338 EFK------------------------GSLSGSNAGITSIEFDSAGSYLLAASNDFASRI 373
Query: 121 VDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKC 180
V D + T GH VLS F + + S S D ++++W + + C + C
Sbjct: 374 WTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSC 433
Query: 181 NDVINAKSICRLA---------WQPKS----------GKLLAI---PVEKSVKLYRRESW 218
ND++ + C ++ W +S GK+ A+ P + R+
Sbjct: 434 NDIVCTEQ-CVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRDDL 492
Query: 219 SHQFDLSDNFISQTLNI-----------VTWSPCGQYLAAGSINGLIIVWNVETKDCMER 267
DL N I QT + V +SP G Y+AAGS G + +W+V T +
Sbjct: 493 LKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKV 552
Query: 268 VKHEKGYAICGLAWHPTCGRISYTD 292
+ + +I +AW P+ + D
Sbjct: 553 LSKQHSSSINAVAWSPSGSHVVSVD 577
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 63.5 bits (153), Expect = 1e-09
Identities = 40/160 (25%), Positives = 70/160 (43%), Gaps = 5/160 (3%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGKLVTA 70
GHT+ T V F S + + D +RIW + + + E A +
Sbjct: 262 GHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYL 321
Query: 71 VSNNTIQVHTFPEGVPDGILTRFTTNANH-----VVFNGDGTKIAAGSSDFLVKIVDVMD 125
+S++ Q F + +LT+ T + F+ DG G+ D +KI D+ +
Sbjct: 322 LSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKE 381
Query: 126 SSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQI 165
+ F GH P+ S++F +LA+A+ D SV++W +
Sbjct: 382 RTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDL 421
Score = 43.9 bits (102), Expect = 9e-04
Identities = 21/66 (31%), Positives = 32/66 (48%)
Query: 105 DGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQ 164
D KI G +D V + D T +GH V S+ F P + SAS D ++R+W
Sbjct: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292
Query: 165 ISDQTC 170
+ + +C
Sbjct: 293 VPNASC 298
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 63.2 bits (152), Expect = 1e-09
Identities = 47/206 (22%), Positives = 97/206 (47%), Gaps = 21/206 (10%)
Query: 105 DGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQ 164
+ T A+ S+D + + + KTF+GH V ++ +DP + LAS S D ++++W
Sbjct: 330 NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 389
Query: 165 ISDQTCAISWPLLQKCNDVINAKSICRLAWQP---------KSGKLLAIPVEKSVKLYRR 215
+ + C LQ N K I + W P + L + + +V+L+
Sbjct: 390 MKQEVCIHD---LQAHN-----KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 441
Query: 216 ESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYA 275
E L+ + + + V +SP G+YLA+GS + + +WN ++ + + + G
Sbjct: 442 ERGVCTHTLTKH--QEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGG-- 497
Query: 276 ICGLAWHPTCGRISYTDAEGNLGLLE 301
I + W+ ++ + ++G++ +L+
Sbjct: 498 IFEVCWNARGDKVGASASDGSVCVLD 523
Score = 47.0 bits (110), Expect = 1e-04
Identities = 37/150 (24%), Positives = 70/150 (46%), Gaps = 13/150 (8%)
Query: 126 SSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPL-LQKC---- 180
SS+ RGH++ V +++P LAS S D + R+W +++ + S L L+ C
Sbjct: 171 SSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 230
Query: 181 -NDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQ--TLNIVT 237
+DV + K + L W +G LLA S + R W+ +L+ + +
Sbjct: 231 GHDVPSNKDVTSLDWN-TNGTLLA---TGSYDGFAR-IWTEDGNLASTLGQHKGPIFALK 285
Query: 238 WSPCGQYLAAGSINGLIIVWNVETKDCMER 267
W+ G Y+ + ++ I+W+ T + ++
Sbjct: 286 WNRKGNYILSAGVDKTTIIWDAHTGEAKQQ 315
Score = 45.1 bits (105), Expect = 4e-04
Identities = 37/164 (22%), Positives = 70/164 (42%), Gaps = 13/164 (7%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWE--------DLDDDDPKFINVGEKAYSCAL 62
GHT + +D SG + +C D ++IW DL + + + A
Sbjct: 359 GHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPAT 418
Query: 63 KSGK----LVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLV 118
+ L +A ++T+++ GV LT+ V F+ DG +A+GS D V
Sbjct: 419 SNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCV 478
Query: 119 KIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRV 162
I + + ++RG + + ++ + + +++ DGSV V
Sbjct: 479 HIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCV 521
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 63.2 bits (152), Expect = 1e-09
Identities = 47/206 (22%), Positives = 97/206 (47%), Gaps = 21/206 (10%)
Query: 105 DGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQ 164
+ T A+ S+D + + + KTF+GH V ++ +DP + LAS S D ++++W
Sbjct: 330 NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 389
Query: 165 ISDQTCAISWPLLQKCNDVINAKSICRLAWQP---------KSGKLLAIPVEKSVKLYRR 215
+ + C LQ N K I + W P + L + + +V+L+
Sbjct: 390 MKQEVCIHD---LQAHN-----KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 441
Query: 216 ESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYA 275
E L+ + + + V +SP G+YLA+GS + + +WN ++ + + + G
Sbjct: 442 ERGVCTHTLTKH--QEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGG-- 497
Query: 276 ICGLAWHPTCGRISYTDAEGNLGLLE 301
I + W+ ++ + ++G++ +L+
Sbjct: 498 IFEVCWNARGDKVGASASDGSVCVLD 523
Score = 47.0 bits (110), Expect = 1e-04
Identities = 37/150 (24%), Positives = 70/150 (46%), Gaps = 13/150 (8%)
Query: 126 SSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPL-LQKC---- 180
SS+ RGH++ V +++P LAS S D + R+W +++ + S L L+ C
Sbjct: 171 SSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 230
Query: 181 -NDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQ--TLNIVT 237
+DV + K + L W +G LLA S + R W+ +L+ + +
Sbjct: 231 GHDVPSNKDVTSLDWN-TNGTLLA---TGSYDGFAR-IWTEDGNLASTLGQHKGPIFALK 285
Query: 238 WSPCGQYLAAGSINGLIIVWNVETKDCMER 267
W+ G Y+ + ++ I+W+ T + ++
Sbjct: 286 WNRKGNYILSAGVDKTTIIWDAHTGEAKQQ 315
Score = 45.1 bits (105), Expect = 4e-04
Identities = 37/164 (22%), Positives = 70/164 (42%), Gaps = 13/164 (7%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWE--------DLDDDDPKFINVGEKAYSCAL 62
GHT + +D SG + +C D ++IW DL + + + A
Sbjct: 359 GHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPAT 418
Query: 63 KSGK----LVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLV 118
+ L +A ++T+++ GV LT+ V F+ DG +A+GS D V
Sbjct: 419 SNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCV 478
Query: 119 KIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRV 162
I + + ++RG + + ++ + + +++ DGSV V
Sbjct: 479 HIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCV 521
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 63.2 bits (152), Expect = 1e-09
Identities = 47/206 (22%), Positives = 97/206 (47%), Gaps = 21/206 (10%)
Query: 105 DGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQ 164
+ T A+ S+D + + + KTF+GH V ++ +DP + LAS S D ++++W
Sbjct: 381 NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 440
Query: 165 ISDQTCAISWPLLQKCNDVINAKSICRLAWQP---------KSGKLLAIPVEKSVKLYRR 215
+ + C LQ N K I + W P + L + + +V+L+
Sbjct: 441 MKQEVCIHD---LQAHN-----KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 492
Query: 216 ESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYA 275
E L+ + + + V +SP G+YLA+GS + + +WN ++ + + + G
Sbjct: 493 ERGVCTHTLTKH--QEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGG-- 548
Query: 276 ICGLAWHPTCGRISYTDAEGNLGLLE 301
I + W+ ++ + ++G++ +L+
Sbjct: 549 IFEVCWNARGDKVGASASDGSVCVLD 574
Score = 47.0 bits (110), Expect = 1e-04
Identities = 37/150 (24%), Positives = 70/150 (46%), Gaps = 13/150 (8%)
Query: 126 SSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPL-LQKC---- 180
SS+ RGH++ V +++P LAS S D + R+W +++ + S L L+ C
Sbjct: 222 SSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 281
Query: 181 -NDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQ--TLNIVT 237
+DV + K + L W +G LLA S + R W+ +L+ + +
Sbjct: 282 GHDVPSNKDVTSLDWN-TNGTLLA---TGSYDGFAR-IWTEDGNLASTLGQHKGPIFALK 336
Query: 238 WSPCGQYLAAGSINGLIIVWNVETKDCMER 267
W+ G Y+ + ++ I+W+ T + ++
Sbjct: 337 WNRKGNYILSAGVDKTTIIWDAHTGEAKQQ 366
Score = 45.1 bits (105), Expect = 4e-04
Identities = 37/164 (22%), Positives = 70/164 (42%), Gaps = 13/164 (7%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWE--------DLDDDDPKFINVGEKAYSCAL 62
GHT + +D SG + +C D ++IW DL + + + A
Sbjct: 410 GHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPAT 469
Query: 63 KSGK----LVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLV 118
+ L +A ++T+++ GV LT+ V F+ DG +A+GS D V
Sbjct: 470 SNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCV 529
Query: 119 KIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRV 162
I + + ++RG + + ++ + + +++ DGSV V
Sbjct: 530 HIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCV 572
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 63.2 bits (152), Expect = 1e-09
Identities = 47/206 (22%), Positives = 97/206 (47%), Gaps = 21/206 (10%)
Query: 105 DGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQ 164
+ T A+ S+D + + + KTF+GH V ++ +DP + LAS S D ++++W
Sbjct: 381 NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWS 440
Query: 165 ISDQTCAISWPLLQKCNDVINAKSICRLAWQP---------KSGKLLAIPVEKSVKLYRR 215
+ + C LQ N K I + W P + L + + +V+L+
Sbjct: 441 MKQEVCIHD---LQAHN-----KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 492
Query: 216 ESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYA 275
E L+ + + + V +SP G+YLA+GS + + +WN ++ + + + G
Sbjct: 493 ERGVCTHTLTKH--QEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGG-- 548
Query: 276 ICGLAWHPTCGRISYTDAEGNLGLLE 301
I + W+ ++ + ++G++ +L+
Sbjct: 549 IFEVCWNARGDKVGASASDGSVCVLD 574
Score = 47.0 bits (110), Expect = 1e-04
Identities = 37/150 (24%), Positives = 70/150 (46%), Gaps = 13/150 (8%)
Query: 126 SSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPL-LQKC---- 180
SS+ RGH++ V +++P LAS S D + R+W +++ + S L L+ C
Sbjct: 222 SSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREG 281
Query: 181 -NDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQ--TLNIVT 237
+DV + K + L W +G LLA S + R W+ +L+ + +
Sbjct: 282 GHDVPSNKDVTSLDWN-TNGTLLA---TGSYDGFAR-IWTEDGNLASTLGQHKGPIFALK 336
Query: 238 WSPCGQYLAAGSINGLIIVWNVETKDCMER 267
W+ G Y+ + ++ I+W+ T + ++
Sbjct: 337 WNRKGNYILSAGVDKTTIIWDAHTGEAKQQ 366
Score = 45.1 bits (105), Expect = 4e-04
Identities = 37/164 (22%), Positives = 70/164 (42%), Gaps = 13/164 (7%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWE--------DLDDDDPKFINVGEKAYSCAL 62
GHT + +D SG + +C D ++IW DL + + + A
Sbjct: 410 GHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPAT 469
Query: 63 KSGK----LVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLV 118
+ L +A ++T+++ GV LT+ V F+ DG +A+GS D V
Sbjct: 470 SNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCV 529
Query: 119 KIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRV 162
I + + ++RG + + ++ + + +++ DGSV V
Sbjct: 530 HIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCV 572
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 62.0 bits (149), Expect = 3e-09
Identities = 64/269 (23%), Positives = 111/269 (41%), Gaps = 56/269 (20%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGKLVTA 70
GH V + SG+ + TC D V +WE ++D+ Y C
Sbjct: 103 GHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDE----------YECV--------- 143
Query: 71 VSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQ- 129
+L T + HVV++ +A+ S D VK+ +
Sbjct: 144 -----------------SVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVC 186
Query: 130 -KTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQI----SDQTCAI-----SWPLLQK 179
T GH++ V SL+FDP LAS S D +VR+W+ ++Q A SW +
Sbjct: 187 CATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICT 246
Query: 180 CNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSH----QFDLSDNF---ISQT 232
+ ++++I +AW +G L + ++++++ + S F L+ + SQ
Sbjct: 247 LSG-FHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQD 305
Query: 233 LNIVTWSPCGQ-YLAAGSINGLIIVWNVE 260
+N V W+P LA+ S +G + W +
Sbjct: 306 VNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334
Score = 47.4 bits (111), Expect = 8e-05
Identities = 32/107 (29%), Positives = 53/107 (49%), Gaps = 14/107 (13%)
Query: 192 LAWQPKSGKLLAIPVEKSVKLYRRE--SWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGS 249
LAW P L + ++ ++++ E SW + LS+ +T+ V WSPCG YLA+ S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGH-QRTVRKVAWSPCGNYLASAS 80
Query: 250 INGLIIVW--NVETKDCMERVK-HEKGYAICGLAWHP------TCGR 287
+ +W N + +C+ ++ HE + +AW P TC R
Sbjct: 81 FDATTCIWKKNQDDFECVTTLEGHEN--EVKSVAWAPSGNLLATCSR 125
Score = 43.9 bits (102), Expect = 9e-04
Identities = 32/148 (21%), Positives = 63/148 (42%), Gaps = 13/148 (8%)
Query: 142 LSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINA---KSICRLAWQPKS 198
L+++P LAS D +R+W SW C V++ +++ ++AW P
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGD----SWI----CKSVLSEGHQRTVRKVAWSPCG 73
Query: 199 GKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWN 258
L + + + ++++ + + + V W+P G LA S + + VW
Sbjct: 74 NYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
Query: 259 VETKDCMERVKHEKGYA--ICGLAWHPT 284
V+ +D E V + + + WHP+
Sbjct: 134 VDEEDEYECVSVLNSHTQDVKHVVWHPS 161
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 61.2 bits (147), Expect = 5e-09
Identities = 71/302 (23%), Positives = 126/302 (41%), Gaps = 36/302 (11%)
Query: 17 TEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGE-KAYSCALKSGK-----LVTA 70
T + ++ G+ + T DG RIW D +G+ K ALK K L
Sbjct: 229 TSLDWNSEGTLLATGSYDGFARIWTK---DGNLASTLGQHKGPIFALKWNKKGNFILSAG 285
Query: 71 VSNNTI--QVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQ 128
V TI HT G + A V + + T A+ S+D + + +
Sbjct: 286 VDKTTIIWDAHT---GEAKQQFPFHSAPALDVDWQSNNT-FASCSTDMCIHVCKLGQDRP 341
Query: 129 QKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKS 188
KTF+GH V ++ +DP LAS S D ++++W + C LQ N K
Sbjct: 342 IKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHD---LQAHN-----KE 393
Query: 189 ICRLAWQPKSG---------KLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWS 239
I + W P L + + +V+L+ + L+ + + + V +S
Sbjct: 394 IYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKH--QEPVYSVAFS 451
Query: 240 PCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGL 299
P G+YLA+GS + + +WN +T + + G I + W+ ++ + ++G++ +
Sbjct: 452 PDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGG--IFEVCWNAAGDKVGASASDGSVCV 509
Query: 300 LE 301
L+
Sbjct: 510 LD 511
Score = 45.1 bits (105), Expect = 4e-04
Identities = 43/174 (24%), Positives = 79/174 (45%), Gaps = 15/174 (8%)
Query: 103 NGDGTKIAAGSSDFLVKIVDV-MDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVR 161
NG T IA +D + DV + ++ RGH++ V +++P LAS S D + R
Sbjct: 136 NGAHT-IANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTAR 194
Query: 162 VWQISDQTCAISWPL-LQKC-----NDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRR 215
+W +S+ + + S L L+ C DV + K + L W G LLA S + R
Sbjct: 195 IWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWN-SEGTLLA---TGSYDGFAR 250
Query: 216 ESWSHQFDLSDNFISQ--TLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMER 267
W+ +L+ + + W+ G ++ + ++ I+W+ T + ++
Sbjct: 251 -IWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQ 303
Score = 44.7 bits (104), Expect = 5e-04
Identities = 38/153 (24%), Positives = 62/153 (40%), Gaps = 30/153 (19%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGKLVTA 70
GHT + +D +G+ + +C D ++IW ++K V
Sbjct: 347 GHTNEVNAIKWDPTGNLLASCSDDMTLKIW--------------------SMKQDNCVHD 386
Query: 71 VSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQK 130
+ + +++T + P G T NAN +A+ S D V++ DV
Sbjct: 387 LQAHNKEIYTI-KWSPTGPGTN-NPNAN--------LMLASASFDSTVRLWDVDRGICIH 436
Query: 131 TFRGHDAPVLSLSFDPKDIFLASASCDGSVRVW 163
T H PV S++F P +LAS S D V +W
Sbjct: 437 TLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIW 469
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 60.8 bits (146), Expect = 7e-09
Identities = 42/164 (25%), Positives = 71/164 (43%), Gaps = 19/164 (11%)
Query: 12 HTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGK---LV 68
HT+ CF + G I +CG+D +++++ + I E C S +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 69 TAVSNNTIQ---------VHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVK 119
T + ++ VHT+ E FT +++H++ +A GSSD +K
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL-------LATGSSDCFLK 726
Query: 120 IVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVW 163
+ D+ + T GH V F P D LAS S DG++++W
Sbjct: 727 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 770
Score = 42.0 bits (97), Expect = 0.003
Identities = 57/274 (20%), Positives = 109/274 (39%), Gaps = 49/274 (17%)
Query: 10 YGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGKLVT 69
+GHT F + +C +DG +++W+ ++ K INV K + L+
Sbjct: 740 FGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINV--KQFFLNLED----- 792
Query: 70 AVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQ 129
P+ + I+ + +A DG +I + + + + + S+
Sbjct: 793 ------------PQEDMEVIVKCCSWSA-------DGARIMVAAKN-KIFLWNTDSRSKV 832
Query: 130 KTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSI 189
RGH + V + F P ++S D ++R+W+ + + C S +L++ DV+
Sbjct: 833 ADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE-TKKVCKNSAVMLKQEVDVV----- 886
Query: 190 CRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGS 249
+Q +LA+ + ++L + D ++ SP QY+A G
Sbjct: 887 ----FQENEVMVLAVDHIRRLQLINGRTGQ-----IDYLTEAQVSCCCLSPHLQYIAFGD 937
Query: 250 INGLI-IVWNVETKDCMERVKHEKGYAICGLAWH 282
NG I I+ V + R +H+K WH
Sbjct: 938 ENGAIEILELVNNRIFQSRFQHKK------TVWH 965
Score = 36.6 bits (83), Expect = 0.14
Identities = 31/161 (19%), Positives = 65/161 (40%), Gaps = 3/161 (1%)
Query: 9 RYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSC--ALKSGK 66
R+ H + + F +++ D ++++W + D F+ ++ LK+ +
Sbjct: 956 RFQHKKTVWHIQFTADEKTLISSSDDAEIQVW-NWQLDKCIFLRGHQETVKDFRLLKNSR 1014
Query: 67 LVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDS 126
L++ + T++V G + + D TK ++ S+D KI
Sbjct: 1015 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1074
Query: 127 SQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISD 167
RGH+ V +F LA+ +G +R+W +S+
Sbjct: 1075 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1115
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 60.8 bits (146), Expect = 7e-09
Identities = 42/164 (25%), Positives = 71/164 (43%), Gaps = 19/164 (11%)
Query: 12 HTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGK---LV 68
HT+ CF + G I +CG+D +++++ + I E C S +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 69 TAVSNNTIQ---------VHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVK 119
T + ++ VHT+ E FT +++H++ +A GSSD +K
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL-------LATGSSDCFLK 726
Query: 120 IVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVW 163
+ D+ + T GH V F P D LAS S DG++++W
Sbjct: 727 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 770
Score = 55.8 bits (133), Expect = 2e-07
Identities = 59/290 (20%), Positives = 111/290 (38%), Gaps = 38/290 (13%)
Query: 10 YGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGE-------------- 55
+GHT F + +C +DG +++W+ ++ K INV +
Sbjct: 740 FGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEV 799
Query: 56 --KAYSCALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGS 113
K S + +++ A N G+ I T + + F+
Sbjct: 800 IVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVAL 859
Query: 114 SDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAIS 173
S + V++ + S+ RGH + V + F P ++S D ++R+W+ + + C S
Sbjct: 860 SQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE-TKKVCKNS 918
Query: 174 WPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTL 233
+L++ DV+ +Q +LA+ + ++L + D +
Sbjct: 919 AVMLKQEVDVV---------FQENEVMVLAVDHIRRLQLINGRTGQ-----IDYLTEAQV 964
Query: 234 NIVTWSPCGQYLAAGSINGLI-IVWNVETKDCMERVKHEKGYAICGLAWH 282
+ SP QY+A G NG I I+ V + R +H+K WH
Sbjct: 965 SCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKK------TVWH 1008
Score = 36.6 bits (83), Expect = 0.14
Identities = 31/161 (19%), Positives = 65/161 (40%), Gaps = 3/161 (1%)
Query: 9 RYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSC--ALKSGK 66
R+ H + + F +++ D ++++W + D F+ ++ LK+ +
Sbjct: 999 RFQHKKTVWHIQFTADEKTLISSSDDAEIQVW-NWQLDKCIFLRGHQETVKDFRLLKNSR 1057
Query: 67 LVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDS 126
L++ + T++V G + + D TK ++ S+D KI
Sbjct: 1058 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1117
Query: 127 SQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISD 167
RGH+ V +F LA+ +G +R+W +S+
Sbjct: 1118 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1158
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 60.8 bits (146), Expect = 7e-09
Identities = 42/164 (25%), Positives = 71/164 (43%), Gaps = 19/164 (11%)
Query: 12 HTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGK---LV 68
HT+ CF + G I +CG+D +++++ + I E C S +
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
Query: 69 TAVSNNTIQ---------VHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVK 119
T + ++ VHT+ E FT +++H++ +A GSSD +K
Sbjct: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL-------LATGSSDCFLK 715
Query: 120 IVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVW 163
+ D+ + T GH V F P D LAS S DG++++W
Sbjct: 716 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 759
Score = 42.0 bits (97), Expect = 0.003
Identities = 57/274 (20%), Positives = 109/274 (39%), Gaps = 49/274 (17%)
Query: 10 YGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGKLVT 69
+GHT F + +C +DG +++W+ ++ K INV K + L+
Sbjct: 729 FGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINV--KQFFLNLED----- 781
Query: 70 AVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQ 129
P+ + I+ + +A DG +I + + + + + S+
Sbjct: 782 ------------PQEDMEVIVKCCSWSA-------DGARIMVAAKN-KIFLWNTDSRSKV 821
Query: 130 KTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSI 189
RGH + V + F P ++S D ++R+W+ + + C S +L++ DV+
Sbjct: 822 ADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE-TKKVCKNSAVMLKQEVDVV----- 875
Query: 190 CRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGS 249
+Q +LA+ + ++L + D ++ SP QY+A G
Sbjct: 876 ----FQENEVMVLAVDHIRRLQLINGRTGQ-----IDYLTEAQVSCCCLSPHLQYIAFGD 926
Query: 250 INGLI-IVWNVETKDCMERVKHEKGYAICGLAWH 282
NG I I+ V + R +H+K WH
Sbjct: 927 ENGAIEILELVNNRIFQSRFQHKK------TVWH 954
Score = 36.6 bits (83), Expect = 0.14
Identities = 31/161 (19%), Positives = 65/161 (40%), Gaps = 3/161 (1%)
Query: 9 RYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSC--ALKSGK 66
R+ H + + F +++ D ++++W + D F+ ++ LK+ +
Sbjct: 945 RFQHKKTVWHIQFTADEKTLISSSDDAEIQVW-NWQLDKCIFLRGHQETVKDFRLLKNSR 1003
Query: 67 LVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDS 126
L++ + T++V G + + D TK ++ S+D KI
Sbjct: 1004 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1063
Query: 127 SQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISD 167
RGH+ V +F LA+ +G +R+W +S+
Sbjct: 1064 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1104
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 60.8 bits (146), Expect = 7e-09
Identities = 42/164 (25%), Positives = 71/164 (43%), Gaps = 19/164 (11%)
Query: 12 HTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGK---LV 68
HT+ CF + G I +CG+D +++++ + I E C S +
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
Query: 69 TAVSNNTIQ---------VHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVK 119
T + ++ VHT+ E FT +++H++ +A GSSD +K
Sbjct: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL-------LATGSSDCFLK 715
Query: 120 IVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVW 163
+ D+ + T GH V F P D LAS S DG++++W
Sbjct: 716 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 759
Score = 55.8 bits (133), Expect = 2e-07
Identities = 59/290 (20%), Positives = 111/290 (38%), Gaps = 38/290 (13%)
Query: 10 YGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGE-------------- 55
+GHT F + +C +DG +++W+ ++ K INV +
Sbjct: 729 FGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEV 788
Query: 56 --KAYSCALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGS 113
K S + +++ A N G+ I T + + F+
Sbjct: 789 IVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVAL 848
Query: 114 SDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAIS 173
S + V++ + S+ RGH + V + F P ++S D ++R+W+ + + C S
Sbjct: 849 SQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE-TKKVCKNS 907
Query: 174 WPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTL 233
+L++ DV+ +Q +LA+ + ++L + D +
Sbjct: 908 AVMLKQEVDVV---------FQENEVMVLAVDHIRRLQLINGRTGQ-----IDYLTEAQV 953
Query: 234 NIVTWSPCGQYLAAGSINGLI-IVWNVETKDCMERVKHEKGYAICGLAWH 282
+ SP QY+A G NG I I+ V + R +H+K WH
Sbjct: 954 SCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKK------TVWH 997
Score = 36.6 bits (83), Expect = 0.14
Identities = 31/161 (19%), Positives = 65/161 (40%), Gaps = 3/161 (1%)
Query: 9 RYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSC--ALKSGK 66
R+ H + + F +++ D ++++W + D F+ ++ LK+ +
Sbjct: 988 RFQHKKTVWHIQFTADEKTLISSSDDAEIQVW-NWQLDKCIFLRGHQETVKDFRLLKNSR 1046
Query: 67 LVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDS 126
L++ + T++V G + + D TK ++ S+D KI
Sbjct: 1047 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1106
Query: 127 SQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISD 167
RGH+ V +F LA+ +G +R+W +S+
Sbjct: 1107 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1147
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 60.8 bits (146), Expect = 7e-09
Identities = 58/221 (26%), Positives = 98/221 (44%), Gaps = 18/221 (8%)
Query: 86 PDGILTRFTTNANHVV---FNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSL 142
P RFT + + V F+ G +A+GS D V+I + FR H A V S+
Sbjct: 12 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSV 71
Query: 143 SFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLL 202
F +AS D +V+VW Q S L Q N V AK + P ++
Sbjct: 72 HFCSDGQSFVTASDDKTVKVWATHRQKFLFS--LSQHINWVRCAK------FSPDGRLIV 123
Query: 203 AIPVEKSVKLYRRESWS--HQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVE 260
+ +K+VKL+ + S H + F++ V + P G +AA ++ + VW+V
Sbjct: 124 SASDDKTVKLWDKSSRECVHSYCEHGGFVT----YVDFHPSGTCIAAAGMDNTVKVWDVR 179
Query: 261 TKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLLE 301
T ++ + A+ GL++HP+ + ++ L +L+
Sbjct: 180 THRLLQHYQLHSA-AVNGLSFHPSGNYLITASSDSTLKILD 219
Score = 56.2 bits (134), Expect = 2e-07
Identities = 61/271 (22%), Positives = 110/271 (40%), Gaps = 37/271 (13%)
Query: 2 PATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIW-EDLDDDDPKFINVGEKAYSC 60
P +R GH + T V F SG + + D VRIW ++ + F +A++
Sbjct: 12 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF-----RAHTA 66
Query: 61 ALKS-------GKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGS 113
++S VTA + T++V L++ F+ DG I + S
Sbjct: 67 TVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 126
Query: 114 SDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAIS 173
D VK+ D ++ H V + F P +A+A D +V+VW +
Sbjct: 127 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR---- 182
Query: 174 WPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTL 233
LLQ +++ ++ L++ P L+ + ++K+ DL + + TL
Sbjct: 183 --LLQHYQ--LHSAAVNGLSFHPSGNYLITASSDSTLKI---------LDLMEGRLLYTL 229
Query: 234 N-------IVTWSPCGQYLAAGSINGLIIVW 257
+ V +S G+Y A+G + ++VW
Sbjct: 230 HGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 46.2 bits (108), Expect = 2e-04
Identities = 36/147 (24%), Positives = 59/147 (40%), Gaps = 3/147 (2%)
Query: 21 FDDSGSFIVTCGSDGDVRIWEDLDDDDPKFI--NVGEKAYSCALKSGKLVTAVS-NNTIQ 77
F G IV+ D V++W+ + + G Y SG + A +NT++
Sbjct: 115 FSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVK 174
Query: 78 VHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDA 137
V + N + F+ G + SSD +KI+D+M+ T GH
Sbjct: 175 VWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQG 234
Query: 138 PVLSLSFDPKDIFLASASCDGSVRVWQ 164
P +++F + AS D V VW+
Sbjct: 235 PATTVAFSRTGEYFASGGSDEQVMVWK 261
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 60.8 bits (146), Expect = 7e-09
Identities = 58/221 (26%), Positives = 98/221 (44%), Gaps = 18/221 (8%)
Query: 86 PDGILTRFTTNANHVV---FNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSL 142
P RFT + + V F+ G +A+GS D V+I + FR H A V S+
Sbjct: 50 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSV 109
Query: 143 SFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLL 202
F +AS D +V+VW Q S L Q N V AK + P ++
Sbjct: 110 HFCSDGQSFVTASDDKTVKVWATHRQKFLFS--LSQHINWVRCAK------FSPDGRLIV 161
Query: 203 AIPVEKSVKLYRRESWS--HQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVE 260
+ +K+VKL+ + S H + F++ V + P G +AA ++ + VW+V
Sbjct: 162 SASDDKTVKLWDKSSRECVHSYCEHGGFVT----YVDFHPSGTCIAAAGMDNTVKVWDVR 217
Query: 261 TKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLLE 301
T ++ + A+ GL++HP+ + ++ L +L+
Sbjct: 218 THRLLQHYQLHSA-AVNGLSFHPSGNYLITASSDSTLKILD 257
Score = 56.2 bits (134), Expect = 2e-07
Identities = 61/271 (22%), Positives = 110/271 (40%), Gaps = 37/271 (13%)
Query: 2 PATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIW-EDLDDDDPKFINVGEKAYSC 60
P +R GH + T V F SG + + D VRIW ++ + F +A++
Sbjct: 50 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF-----RAHTA 104
Query: 61 ALKS-------GKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGS 113
++S VTA + T++V L++ F+ DG I + S
Sbjct: 105 TVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 164
Query: 114 SDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAIS 173
D VK+ D ++ H V + F P +A+A D +V+VW +
Sbjct: 165 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR---- 220
Query: 174 WPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTL 233
LLQ +++ ++ L++ P L+ + ++K+ DL + + TL
Sbjct: 221 --LLQHYQ--LHSAAVNGLSFHPSGNYLITASSDSTLKI---------LDLMEGRLLYTL 267
Query: 234 N-------IVTWSPCGQYLAAGSINGLIIVW 257
+ V +S G+Y A+G + ++VW
Sbjct: 268 HGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 46.2 bits (108), Expect = 2e-04
Identities = 36/147 (24%), Positives = 59/147 (40%), Gaps = 3/147 (2%)
Query: 21 FDDSGSFIVTCGSDGDVRIWEDLDDDDPKFI--NVGEKAYSCALKSGKLVTAVS-NNTIQ 77
F G IV+ D V++W+ + + G Y SG + A +NT++
Sbjct: 153 FSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVK 212
Query: 78 VHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDA 137
V + N + F+ G + SSD +KI+D+M+ T GH
Sbjct: 213 VWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQG 272
Query: 138 PVLSLSFDPKDIFLASASCDGSVRVWQ 164
P +++F + AS D V VW+
Sbjct: 273 PATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 32.3 bits (72), Expect = 2.6
Identities = 36/194 (18%), Positives = 70/194 (36%), Gaps = 37/194 (19%)
Query: 125 DSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVI 184
D S ++ F+GH V + F LAS S D + VW + Q+ A + + +
Sbjct: 8 DPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCV 67
Query: 185 NAKSICRLAWQPKSGKLLAIPV----------------------------------EKSV 210
N L K + I V +K+V
Sbjct: 68 NFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTV 127
Query: 211 KLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKH 270
K++ F LS + + +SP G+ + + S + + +W+ +++C+
Sbjct: 128 KVWATHRQKFLFSLSQHI--NWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE 185
Query: 271 EKGYAICGLAWHPT 284
G+ + + +HP+
Sbjct: 186 HGGF-VTYVDFHPS 198
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 60.8 bits (146), Expect = 7e-09
Identities = 58/221 (26%), Positives = 98/221 (44%), Gaps = 18/221 (8%)
Query: 86 PDGILTRFTTNANHVV---FNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSL 142
P RFT + + V F+ G +A+GS D V+I + FR H A V S+
Sbjct: 50 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSV 109
Query: 143 SFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLL 202
F +AS D +V+VW Q S L Q N V AK + P ++
Sbjct: 110 HFCSDGQSFVTASDDKTVKVWATHRQKFLFS--LSQHINWVRCAK------FSPDGRLIV 161
Query: 203 AIPVEKSVKLYRRESWS--HQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVE 260
+ +K+VKL+ + S H + F++ V + P G +AA ++ + VW+V
Sbjct: 162 SASDDKTVKLWDKSSRECVHSYCEHGGFVT----YVDFHPSGTCIAAAGMDNTVKVWDVR 217
Query: 261 TKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLLE 301
T ++ + A+ GL++HP+ + ++ L +L+
Sbjct: 218 THRLLQHYQLHSA-AVNGLSFHPSGNYLITASSDSTLKILD 257
Score = 56.2 bits (134), Expect = 2e-07
Identities = 61/271 (22%), Positives = 110/271 (40%), Gaps = 37/271 (13%)
Query: 2 PATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIW-EDLDDDDPKFINVGEKAYSC 60
P +R GH + T V F SG + + D VRIW ++ + F +A++
Sbjct: 50 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF-----RAHTA 104
Query: 61 ALKS-------GKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGS 113
++S VTA + T++V L++ F+ DG I + S
Sbjct: 105 TVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 164
Query: 114 SDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAIS 173
D VK+ D ++ H V + F P +A+A D +V+VW +
Sbjct: 165 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR---- 220
Query: 174 WPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTL 233
LLQ +++ ++ L++ P L+ + ++K+ DL + + TL
Sbjct: 221 --LLQHYQ--LHSAAVNGLSFHPSGNYLITASSDSTLKI---------LDLMEGRLLYTL 267
Query: 234 N-------IVTWSPCGQYLAAGSINGLIIVW 257
+ V +S G+Y A+G + ++VW
Sbjct: 268 HGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 46.2 bits (108), Expect = 2e-04
Identities = 36/147 (24%), Positives = 59/147 (40%), Gaps = 3/147 (2%)
Query: 21 FDDSGSFIVTCGSDGDVRIWEDLDDDDPKFI--NVGEKAYSCALKSGKLVTAVS-NNTIQ 77
F G IV+ D V++W+ + + G Y SG + A +NT++
Sbjct: 153 FSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVK 212
Query: 78 VHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDA 137
V + N + F+ G + SSD +KI+D+M+ T GH
Sbjct: 213 VWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQG 272
Query: 138 PVLSLSFDPKDIFLASASCDGSVRVWQ 164
P +++F + AS D V VW+
Sbjct: 273 PATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 32.3 bits (72), Expect = 2.6
Identities = 36/194 (18%), Positives = 70/194 (36%), Gaps = 37/194 (19%)
Query: 125 DSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVI 184
D S ++ F+GH V + F LAS S D + VW + Q+ A + + +
Sbjct: 8 DPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCV 67
Query: 185 NAKSICRLAWQPKSGKLLAIPV----------------------------------EKSV 210
N L K + I V +K+V
Sbjct: 68 NFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTV 127
Query: 211 KLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKH 270
K++ F LS + + +SP G+ + + S + + +W+ +++C+
Sbjct: 128 KVWATHRQKFLFSLSQHI--NWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE 185
Query: 271 EKGYAICGLAWHPT 284
G+ + + +HP+
Sbjct: 186 HGGF-VTYVDFHPS 198
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 60.5 bits (145), Expect = 9e-09
Identities = 46/201 (22%), Positives = 93/201 (46%), Gaps = 21/201 (10%)
Query: 110 AAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQT 169
A+ S+D + + + KTF+GH V ++ +DP + LAS S D ++++W +
Sbjct: 333 ASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDA 392
Query: 170 CAISWPLLQKCNDVINAKSICRLAWQP---------KSGKLLAIPVEKSVKLYRRESWSH 220
C LQ ++K I + W P S L + + +V+L+ E
Sbjct: 393 CVHD---LQ-----AHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVC 444
Query: 221 QFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLA 280
L + + + V +SP G+YLA+GS + + +WN ++ + + G I +
Sbjct: 445 THTLMKH--QEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGG--IFEVC 500
Query: 281 WHPTCGRISYTDAEGNLGLLE 301
W+ ++ + ++G++ +L+
Sbjct: 501 WNARGDKVGASASDGSVCVLD 521
Score = 47.4 bits (111), Expect = 8e-05
Identities = 38/153 (24%), Positives = 63/153 (41%), Gaps = 30/153 (19%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGKLVTA 70
GHT + +D SG + +C D ++IW ++K V
Sbjct: 357 GHTNEVNAIKWDPSGMLLASCSDDMTLKIW--------------------SMKQDACVHD 396
Query: 71 VSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQK 130
+ ++ +++T + P G T +N N + +A+ S D V++ DV
Sbjct: 397 LQAHSKEIYTI-KWSPTGPAT---SNPNSSIM------LASASFDSTVRLWDVEQGVCTH 446
Query: 131 TFRGHDAPVLSLSFDPKDIFLASASCDGSVRVW 163
T H PV S++F P +LAS S D V +W
Sbjct: 447 TLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 45.1 bits (105), Expect = 4e-04
Identities = 35/143 (24%), Positives = 67/143 (46%), Gaps = 13/143 (9%)
Query: 133 RGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPL-LQKC-----NDVINA 186
RGH++ V +++P LAS S D + R+W +++ + S L L+ C +DV +
Sbjct: 176 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235
Query: 187 KSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQ--TLNIVTWSPCGQY 244
K + L W G LLA+ S + R W+ +L+ + + W+ G Y
Sbjct: 236 KDVTSLDWN-SDGTLLAM---GSYDGFAR-IWTENGNLASTLGQHKGPIFALKWNKKGNY 290
Query: 245 LAAGSINGLIIVWNVETKDCMER 267
+ + ++ I+W+ T + ++
Sbjct: 291 VLSAGVDKTTIIWDAHTGEAKQQ 313
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 60.5 bits (145), Expect = 9e-09
Identities = 46/201 (22%), Positives = 93/201 (46%), Gaps = 21/201 (10%)
Query: 110 AAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQT 169
A+ S+D + + + KTF+GH V ++ +DP + LAS S D ++++W +
Sbjct: 333 ASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDA 392
Query: 170 CAISWPLLQKCNDVINAKSICRLAWQP---------KSGKLLAIPVEKSVKLYRRESWSH 220
C LQ ++K I + W P S L + + +V+L+ E
Sbjct: 393 CVHD---LQ-----AHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVC 444
Query: 221 QFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLA 280
L + + + V +SP G+YLA+GS + + +WN ++ + + G I +
Sbjct: 445 THTLMKH--QEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGG--IFEVC 500
Query: 281 WHPTCGRISYTDAEGNLGLLE 301
W+ ++ + ++G++ +L+
Sbjct: 501 WNARGDKVGASASDGSVCVLD 521
Score = 47.4 bits (111), Expect = 8e-05
Identities = 38/153 (24%), Positives = 63/153 (41%), Gaps = 30/153 (19%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGKLVTA 70
GHT + +D SG + +C D ++IW ++K V
Sbjct: 357 GHTNEVNAIKWDPSGMLLASCSDDMTLKIW--------------------SMKQDACVHD 396
Query: 71 VSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQK 130
+ ++ +++T + P G T +N N + +A+ S D V++ DV
Sbjct: 397 LQAHSKEIYTI-KWSPTGPAT---SNPNSSIM------LASASFDSTVRLWDVEQGVCTH 446
Query: 131 TFRGHDAPVLSLSFDPKDIFLASASCDGSVRVW 163
T H PV S++F P +LAS S D V +W
Sbjct: 447 TLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 45.1 bits (105), Expect = 4e-04
Identities = 35/143 (24%), Positives = 67/143 (46%), Gaps = 13/143 (9%)
Query: 133 RGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPL-LQKC-----NDVINA 186
RGH++ V +++P LAS S D + R+W +++ + S L L+ C +DV +
Sbjct: 176 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235
Query: 187 KSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQ--TLNIVTWSPCGQY 244
K + L W G LLA+ S + R W+ +L+ + + W+ G Y
Sbjct: 236 KDVTSLDWN-SDGTLLAM---GSYDGFAR-IWTENGNLASTLGQHKGPIFALKWNKKGNY 290
Query: 245 LAAGSINGLIIVWNVETKDCMER 267
+ + ++ I+W+ T + ++
Sbjct: 291 VLSAGVDKTTIIWDAHTGEAKQQ 313
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 60.5 bits (145), Expect = 9e-09
Identities = 46/201 (22%), Positives = 93/201 (46%), Gaps = 21/201 (10%)
Query: 110 AAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQT 169
A+ S+D + + + KTF+GH V ++ +DP + LAS S D ++++W +
Sbjct: 333 ASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDA 392
Query: 170 CAISWPLLQKCNDVINAKSICRLAWQP---------KSGKLLAIPVEKSVKLYRRESWSH 220
C LQ ++K I + W P S L + + +V+L+ E
Sbjct: 393 CVHD---LQ-----AHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVC 444
Query: 221 QFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLA 280
L + + + V +SP G+YLA+GS + + +WN ++ + + G I +
Sbjct: 445 THTLMKH--QEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGG--IFEVC 500
Query: 281 WHPTCGRISYTDAEGNLGLLE 301
W+ ++ + ++G++ +L+
Sbjct: 501 WNARGDKVGASASDGSVCVLD 521
Score = 47.4 bits (111), Expect = 8e-05
Identities = 38/153 (24%), Positives = 63/153 (41%), Gaps = 30/153 (19%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGKLVTA 70
GHT + +D SG + +C D ++IW ++K V
Sbjct: 357 GHTNEVNAIKWDPSGMLLASCSDDMTLKIW--------------------SMKQDACVHD 396
Query: 71 VSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQK 130
+ ++ +++T + P G T +N N + +A+ S D V++ DV
Sbjct: 397 LQAHSKEIYTI-KWSPTGPAT---SNPNSSIM------LASASFDSTVRLWDVEQGVCTH 446
Query: 131 TFRGHDAPVLSLSFDPKDIFLASASCDGSVRVW 163
T H PV S++F P +LAS S D V +W
Sbjct: 447 TLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 45.1 bits (105), Expect = 4e-04
Identities = 35/143 (24%), Positives = 67/143 (46%), Gaps = 13/143 (9%)
Query: 133 RGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPL-LQKC-----NDVINA 186
RGH++ V +++P LAS S D + R+W +++ + S L L+ C +DV +
Sbjct: 176 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235
Query: 187 KSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQ--TLNIVTWSPCGQY 244
K + L W G LLA+ S + R W+ +L+ + + W+ G Y
Sbjct: 236 KDVTSLDWN-SDGTLLAM---GSYDGFAR-IWTENGNLASTLGQHKGPIFALKWNKKGNY 290
Query: 245 LAAGSINGLIIVWNVETKDCMER 267
+ + ++ I+W+ T + ++
Sbjct: 291 VLSAGVDKTTIIWDAHTGEAKQQ 313
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 60.1 bits (144), Expect = 1e-08
Identities = 49/202 (24%), Positives = 94/202 (46%), Gaps = 11/202 (5%)
Query: 100 VVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGS 159
V F+ G +A+ S D V++ + F+ H APV S+ F FLA+AS D S
Sbjct: 66 VQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKS 125
Query: 160 VRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWS 219
++VW + Q S L + + V AK + P +++ +K++K++ +
Sbjct: 126 IKVWSMYRQRFLYS--LYRHTHWVRCAK------FSPDGRLIVSCSEDKTIKIWDTTNKQ 177
Query: 220 HQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGL 279
+ SD+ N V ++P G +A+ + + VW+V ++ + G C +
Sbjct: 178 CVNNFSDSV--GFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNC-I 234
Query: 280 AWHPTCGRISYTDAEGNLGLLE 301
++HP+ + ++G L +L+
Sbjct: 235 SFHPSGNYLITASSDGTLKILD 256
Score = 52.8 bits (125), Expect = 2e-06
Identities = 43/164 (26%), Positives = 73/164 (44%), Gaps = 15/164 (9%)
Query: 10 YGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFIN-----VGEKAYSCALKS 64
Y HT F G IV+C D ++IW D + + +N VG + S
Sbjct: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW---DTTNKQCVNNFSDSVGFANFVDFNPS 197
Query: 65 GKLV-TAVSNNTIQVHTFPEGVPDGILTRFTTNA---NHVVFNGDGTKIAAGSSDFLVKI 120
G + +A S+ T++V + +L + ++ N + F+ G + SSD +KI
Sbjct: 198 GTCIASAGSDQTVKVWDVRV---NKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKI 254
Query: 121 VDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQ 164
+D+++ T +GH PV ++SF AS D V +W+
Sbjct: 255 LDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWR 298
Score = 52.4 bits (124), Expect = 2e-06
Identities = 42/154 (27%), Positives = 67/154 (43%), Gaps = 3/154 (1%)
Query: 12 HTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKS--GKLVT 69
HT V F G F+ T D +++W + CA S G+L+
Sbjct: 101 HTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIV 160
Query: 70 AVSNN-TIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQ 128
+ S + TI++ + AN V FN GT IA+ SD VK+ DV +
Sbjct: 161 SCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKL 220
Query: 129 QKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRV 162
+ ++ H V +SF P +L +AS DG++++
Sbjct: 221 LQHYQVHSGGVNCISFHPSGNYLITASSDGTLKI 254
Score = 50.4 bits (119), Expect = 9e-06
Identities = 61/270 (22%), Positives = 107/270 (39%), Gaps = 35/270 (12%)
Query: 2 PATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCA 61
P R GH + T V F G+ + + D VR+W + D KF KA++
Sbjct: 49 PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLW--IPDKRGKFSEF--KAHTAP 104
Query: 62 LKSGK-------LVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSS 114
++S L TA + +I+V + L R T F+ DG I + S
Sbjct: 105 VRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSE 164
Query: 115 DFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISW 174
D +KI D + F + F+P +ASA D +V+VW +
Sbjct: 165 DKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVN------ 218
Query: 175 PLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLN 234
LLQ +++ + +++ P L+ + ++K+ DL + + TL
Sbjct: 219 KLLQHYQ--VHSGGVNCISFHPSGNYLITASSDGTLKI---------LDLLEGRLIYTLQ 267
Query: 235 -------IVTWSPCGQYLAAGSINGLIIVW 257
V++S G+ A+G + +++W
Sbjct: 268 GHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 43.1 bits (100), Expect = 0.001
Identities = 42/172 (24%), Positives = 75/172 (43%), Gaps = 12/172 (6%)
Query: 105 DGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQ 164
+G ++A S D + + + ++ + GH V S+ F P LASAS D +VR+W
Sbjct: 29 NGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLW- 87
Query: 165 ISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVE-KSVKLYRRESWSHQFD 223
I D+ K ++ + R G+ LA E KS+K++ + +F
Sbjct: 88 IPDKR--------GKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW--SMYRQRFL 137
Query: 224 LSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYA 275
S + + +SP G+ + + S + I +W+ K C+ G+A
Sbjct: 138 YSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFA 189
Score = 36.2 bits (82), Expect = 0.18
Identities = 30/135 (22%), Positives = 58/135 (42%), Gaps = 10/135 (7%)
Query: 125 DSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVI 184
D ++ F+GH A + SL P LA+AS D + +W A + V
Sbjct: 7 DPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRY--------VG 58
Query: 185 NAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQY 244
+ + + + P L + +++V+L+ + + + + + V +S GQ+
Sbjct: 59 HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAH--TAPVRSVDFSADGQF 116
Query: 245 LAAGSINGLIIVWNV 259
LA S + I VW++
Sbjct: 117 LATASEDKSIKVWSM 131
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 59.7 bits (143), Expect = 2e-08
Identities = 58/269 (21%), Positives = 114/269 (42%), Gaps = 30/269 (11%)
Query: 17 TEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEK--AYSCALKS---GKLVTAV 71
T V + SGS +T D ++W+ ++ + G + Y+ A + K+ T
Sbjct: 96 TNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLE-GHRNVVYAIAFNNPYGDKIATGS 154
Query: 72 SNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKT 131
+ T ++ + G T + FN T +A GS D K+ D+ + + T
Sbjct: 155 FDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYT 214
Query: 132 FRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICR 191
RGH A ++SLSF+ + + S D +V VW +D ++ L+ C ++ +A
Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD-ADTGRKVN-ILIGHCAEISSAS---- 268
Query: 192 LAWQPKSGKLLAIPVEKSVKLYRRES-------WSHQFDLSDNFISQTLNIVTWSPCGQY 244
W +L ++K+ KL+ + H ++ D+ T G+
Sbjct: 269 FNWD--CSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT---------GKL 317
Query: 245 LAAGSINGLIIVWNVETKDCMERVKHEKG 273
+A S +G +++ T+ C+ +++ +G
Sbjct: 318 IATASADGTARIFSAATRKCIAKLEGHEG 346
Score = 58.9 bits (141), Expect = 3e-08
Identities = 46/207 (22%), Positives = 87/207 (42%), Gaps = 13/207 (6%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALK----SGK 66
GHT + F+ + + T D ++W D+ + + + G A +L +
Sbjct: 175 GHTAEIVCLSFNPQSTLVATGSMDTTAKLW-DIQNGEEVYTLRGHSAEIISLSFNTSGDR 233
Query: 67 LVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDS 126
++T ++T+ V G IL + FN D + I GS D K+ D +
Sbjct: 234 IITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNG 293
Query: 127 SQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINA 186
T GHD +L FD +A+AS DG+ R++ + + C + K +
Sbjct: 294 KCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKC------IAKLEG--HE 345
Query: 187 KSICRLAWQPKSGKLLAIPVEKSVKLY 213
I ++++ P+ LL +K+ +++
Sbjct: 346 GEISKISFNPQGNHLLTGSSDKTARIW 372
Score = 46.6 bits (109), Expect = 1e-04
Identities = 40/168 (23%), Positives = 64/168 (38%), Gaps = 13/168 (7%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKA--------YSCAL 62
GH+ + F+ SG I+T D V +W D D I +G A + C+L
Sbjct: 217 GHSAEIISLSFNTSGDRIITGSFDHTVVVW-DADTGRKVNILIGHCAEISSASFNWDCSL 275
Query: 63 KSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVD 122
++T + T ++ G LT F+ G IA S+D +I
Sbjct: 276 ----ILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFS 331
Query: 123 VMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTC 170
GH+ + +SF+P+ L + S D + R+W C
Sbjct: 332 AATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQC 379
Score = 44.7 bits (104), Expect = 5e-04
Identities = 37/163 (22%), Positives = 66/163 (40%), Gaps = 15/163 (9%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWE--------DLDDDDPKFINVGEKAYSCAL 62
GH + F+ S I+T D ++W+ L D + ++ SC
Sbjct: 259 GHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILD------SCFD 312
Query: 63 KSGKLV-TAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIV 121
+GKL+ TA ++ T ++ + L + + FN G + GSSD +I
Sbjct: 313 YTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
Query: 122 DVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQ 164
D + GH + S +F+ K + + S D + R+W+
Sbjct: 373 DAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 59.7 bits (143), Expect = 2e-08
Identities = 62/278 (22%), Positives = 112/278 (40%), Gaps = 52/278 (18%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAY--SC--ALKSGK 66
GH+ E+ ++ GS + + +D V +W+ + K + G ++ SC A + +
Sbjct: 107 GHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLK-GHTSFVNSCYPARRGPQ 165
Query: 67 LV-TAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMD 125
LV T + T+++ + T V FN +I +G D +K+ D+
Sbjct: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ 224
Query: 126 SSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVIN 185
+ T RGH V LS + +L S + D +VRVW +
Sbjct: 225 NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFA---------------- 268
Query: 186 AKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYL 245
P E+ VK+++ H F+ + L +WSP G +
Sbjct: 269 -------------------PKERCVKIFQGNV--HNFE-------KNLLRCSWSPDGSKI 300
Query: 246 AAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHP 283
AAGS + + VW+ ++ + ++ G +I +A+HP
Sbjct: 301 AAGSADRFVYVWDTTSRRILYKLPGHAG-SINEVAFHP 337
Score = 50.8 bits (120), Expect = 7e-06
Identities = 40/159 (25%), Positives = 70/159 (44%), Gaps = 13/159 (8%)
Query: 19 VCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEK----AYSCALKSGKLVTAVSNN 74
V F+D+ I++ G D D+++W DL + + G S + + L++ +N
Sbjct: 199 VTFNDTSDQIISGGIDNDIKVW-DLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDN 257
Query: 75 TIQVHTFPEGVP--------DGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDS 126
T++V P G + F N ++ DG+KIAAGS+D V + D
Sbjct: 258 TVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSR 317
Query: 127 SQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQI 165
GH + ++F P + + SAS D + + +I
Sbjct: 318 RILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEI 356
Score = 36.6 bits (83), Expect = 0.14
Identities = 20/63 (31%), Positives = 33/63 (52%), Gaps = 1/63 (1%)
Query: 102 FNGDGTKIAAGSSDFLVKIVDVM-DSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSV 160
F+ +G+ +A+ D L+ + +V D T +GH V+ L ++ L SAS D +V
Sbjct: 74 FHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTV 133
Query: 161 RVW 163
VW
Sbjct: 134 AVW 136
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 59.3 bits (142), Expect = 2e-08
Identities = 44/172 (25%), Positives = 73/172 (42%), Gaps = 5/172 (2%)
Query: 4 TRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALK 63
T + GH ++ + + D R+W D P I G A +K
Sbjct: 375 TNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWS-FDRTYPLRIYAGHLADVDCVK 433
Query: 64 ----SGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVK 119
S L T ++ T+++ + +G + T + F+ +G +A+ D +K
Sbjct: 434 FHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLK 493
Query: 120 IVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCA 171
+ D+ + K RGH + SL+F P +ASAS D SVRVW I + C+
Sbjct: 494 LWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCS 545
Score = 46.6 bits (109), Expect = 1e-04
Identities = 45/217 (20%), Positives = 92/217 (42%), Gaps = 14/217 (6%)
Query: 102 FNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVR 161
F D + + + S D ++ D+ + ++GH PV L P ++ AS S D + R
Sbjct: 350 FLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTAR 409
Query: 162 VWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQ 221
+W D+T +PL + + + + P S L +K+V+L+ + +
Sbjct: 410 LWSF-DRT----YPLRIYAGHLADVDCV---KFHPNSNYLATGSTDKTVRLWSAQQ-GNS 460
Query: 222 FDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAW 281
L L++ +SP G+YLA+ + + +W++ + + ++ I L +
Sbjct: 461 VRLFTGHRGPVLSL-AFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTD-NITSLTF 518
Query: 282 HPTCGRISYTDAEGNL---GLLENVCDPSGKTSSSKV 315
P G I+ + ++ + C SSS++
Sbjct: 519 SPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSEL 555
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 57.8 bits (138), Expect = 6e-08
Identities = 51/212 (24%), Positives = 97/212 (45%), Gaps = 13/212 (6%)
Query: 64 SGKLVTAVSNNTIQVHTFPEGVPDGI--LTRFTTNANHVVFNGDGTKIAAGSSDFLVKIV 121
SG+L+ A + +V+ + P+ I LT T+ V N I AGS +++
Sbjct: 32 SGRLL-ATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVW 90
Query: 122 DVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCN 181
D+ + +T GH A + SL F P F+AS S D ++++W I + C +
Sbjct: 91 DLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYR------ 144
Query: 182 DVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPC 241
+++++ L + P L + + +VKL+ + + + + +N+V + P
Sbjct: 145 --GHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGH--TGPVNVVEFHPN 200
Query: 242 GQYLAAGSINGLIIVWNVETKDCMERVKHEKG 273
LA+GS + I W++E + ++ E G
Sbjct: 201 EYLLASGSSDRTIRFWDLEKFQVVSCIEGEPG 232
Score = 57.8 bits (138), Expect = 6e-08
Identities = 46/162 (28%), Positives = 72/162 (44%), Gaps = 11/162 (6%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKS---GKL 67
GHT V + IV G +R+W DL+ +G KA C+L G+
Sbjct: 61 GHTSPVESVRLNTPEELIVAGSQSGSIRVW-DLEAAKILRTLMGHKANICSLDFHPYGEF 119
Query: 68 VTAVSNNT-IQVHTFPEGVPDGILTRFTTNANHVV---FNGDGTKIAAGSSDFLVKIVDV 123
V + S +T I++ G + R+ ++ V F+ DG +A+ + D VK+ D+
Sbjct: 120 VASGSQDTNIKLWDIRR---KGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDL 176
Query: 124 MDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQI 165
F GH PV + F P + LAS S D ++R W +
Sbjct: 177 TAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL 218
Score = 44.3 bits (103), Expect = 7e-04
Identities = 47/183 (25%), Positives = 76/183 (41%), Gaps = 13/183 (7%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGE-KAYSCALKS--GK- 66
GH + F G F+ + D ++++W D+ F G +A C S GK
Sbjct: 103 GHKANICSLDFHPYGEFVASGSQDTNIKLW-DIRRKGCVFRYRGHSQAVRCLRFSPDGKW 161
Query: 67 LVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDS 126
L +A ++T+++ G T N V F+ + +A+GSSD ++ D+
Sbjct: 162 LASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKF 221
Query: 127 SQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTC----AISWPL---LQK 179
G PV S+ F+P L S C S+RV+ + C ++W L
Sbjct: 222 QVVSCIEGEPGPVRSVLFNPDGCCLYS-GCQDSLRVYGWEPERCFDVVLVNWGKVADLAI 280
Query: 180 CND 182
CND
Sbjct: 281 CND 283
Score = 42.7 bits (99), Expect = 0.002
Identities = 37/176 (21%), Positives = 77/176 (43%), Gaps = 14/176 (7%)
Query: 100 VVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGS 159
V+ G +A G D V + + + + GH +PV S+ + + + + S GS
Sbjct: 27 VLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGS 86
Query: 160 VRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLY--RRES 217
+RVW + + I L+ + +IC L + P + + + ++KL+ RR+
Sbjct: 87 IRVWDL--EAAKILRTLMG------HKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKG 138
Query: 218 WSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKG 273
++ SQ + + +SP G++LA+ + + + +W++ M G
Sbjct: 139 CVFRY----RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG 190
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 57.8 bits (138), Expect = 6e-08
Identities = 41/170 (24%), Positives = 74/170 (43%), Gaps = 11/170 (6%)
Query: 3 ATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCAL 62
A+ + YGH+ F +++++ DG VR+W VG K ++ +
Sbjct: 533 ASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL----QTFTCLVGYKGHNYPV 588
Query: 63 KSGKL-------VTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSD 115
+ V+ + ++ P I + N F+ + +A GS+D
Sbjct: 589 WDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSAD 648
Query: 116 FLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQI 165
V++ DV++ + + F GH P+ SL+F P FLA+ + DG V +W I
Sbjct: 649 RTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI 698
Score = 55.5 bits (132), Expect = 3e-07
Identities = 46/191 (24%), Positives = 82/191 (42%), Gaps = 12/191 (6%)
Query: 113 SSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAI 172
S D L +I+D +S+ K GH PV SF P +L S+S DG+VR+W + TC +
Sbjct: 520 SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLV 579
Query: 173 SWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQT 232
+ + + + P ++ ++ +L+ + + + +
Sbjct: 580 GYK--------GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLAD-- 629
Query: 233 LNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTD 292
+N + P Y+A GS + + +W+V +C+ KG I L + P GR T
Sbjct: 630 VNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKG-PIHSLTFSPN-GRFLATG 687
Query: 293 AEGNLGLLENV 303
A LL ++
Sbjct: 688 ATDGRVLLWDI 698
Score = 48.1 bits (113), Expect = 5e-05
Identities = 42/157 (26%), Positives = 65/157 (41%), Gaps = 5/157 (3%)
Query: 11 GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKA-YSCAL---KSGK 66
GH + F G + V+ G D R+W D P I G A +C S
Sbjct: 583 GHNYPVWDTQFSPYGYYFVSGGHDRVARLWAT-DHYQPLRIFAGHLADVNCTRFHPNSNY 641
Query: 67 LVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDS 126
+ T ++ T+++ G I T + + F+ +G +A G++D V + D+
Sbjct: 642 VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701
Query: 127 SQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVW 163
+GH V SL F LAS S D +VR+W
Sbjct: 702 LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 34.7 bits (78), Expect = 0.53
Identities = 18/69 (26%), Positives = 31/69 (44%)
Query: 102 FNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVR 161
F+ G +G D + ++ + F GH A V F P ++A+ S D +VR
Sbjct: 593 FSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVR 652
Query: 162 VWQISDQTC 170
+W + + C
Sbjct: 653 LWDVLNGNC 661
Score = 33.9 bits (76), Expect = 0.90
Identities = 40/180 (22%), Positives = 77/180 (42%), Gaps = 31/180 (17%)
Query: 6 KPMRY--GHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALK 63
+P+R GH F + +++ T +D VR+W+ L+ + + I G K +L
Sbjct: 618 QPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVR-IFTGHKGPIHSLT 676
Query: 64 ---SGK-LVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVK 119
+G+ L T ++ + + G+ G L T + F+ DG +A+GS D V+
Sbjct: 677 FSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVR 736
Query: 120 IVDVM---------------------DSSQQ---KTFRGHDAPVLSLSFDPKDIFLASAS 155
+ D + ++SQ+ T+ PV+ L F +++ LA+ +
Sbjct: 737 LWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAGA 796
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,414,022
Number of Sequences: 37866
Number of extensions: 2222846
Number of successful extensions: 10769
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 153
Number of HSP's successfully gapped in prelim test: 435
Number of HSP's that attempted gapping in prelim test: 8091
Number of HSP's gapped (non-prelim): 2408
length of query: 1129
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1016
effective length of database: 13,968,660
effective search space: 14192158560
effective search space used: 14192158560
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.