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Search of human proteins with 5803121
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5803121 protein disulfide isomerase A5 [Homo sapiens]
(519 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5803121 protein disulfide isomerase A5 [Homo sapiens] 1087 0.0
gi|4758304 protein disulfide isomerase A4 [Homo sapiens] 138 1e-32
gi|42794771 thioredoxin domain containing 5 isoform 1 precursor ... 132 6e-31
gi|5031973 protein disulfide isomerase A6 [Homo sapiens] 124 3e-28
gi|224493972 thioredoxin domain containing 5 isoform 3 [Homo sap... 114 2e-25
gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo s... 111 2e-24
gi|94966757 protein disulfide isomerase A2 [Homo sapiens] 86 6e-17
gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo s... 77 5e-14
gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens] 75 1e-13
gi|151101292 thioredoxin domain containing 1 [Homo sapiens] 62 2e-09
gi|38505222 thioredoxin domain containing 10 [Homo sapiens] 59 1e-08
gi|52487191 thioredoxin domain containing 4 (endoplasmic reticul... 59 1e-08
gi|145580631 quiescin Q6 sulfhydryl oxidase 2 [Homo sapiens] 57 3e-08
gi|21361403 thioredoxin 2 precursor [Homo sapiens] 56 9e-08
gi|51873067 quiescin Q6 sulfhydryl oxidase 1 isoform b [Homo sap... 47 3e-05
gi|13325075 quiescin Q6 sulfhydryl oxidase 1 isoform a [Homo sap... 47 3e-05
gi|28372543 protein disulfide isomerase-like, testis expressed [... 47 6e-05
gi|50592994 thioredoxin [Homo sapiens] 44 5e-04
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap... 42 0.001
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap... 42 0.001
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi... 42 0.001
gi|54633317 thioredoxin domain containing 11 [Homo sapiens] 40 0.004
gi|95113651 glutaredoxin 3 [Homo sapiens] 39 0.009
gi|51510891 thioredoxin domain containing 8 [Homo sapiens] 39 0.009
gi|94421469 disulfide isomerase [Homo sapiens] 37 0.044
gi|40254947 thioredoxin-related transmembrane protein 4 [Homo sa... 36 0.097
gi|237648961 thioredoxin domain containing 16 isoform 2 [Homo sa... 35 0.13
gi|237648959 thioredoxin domain containing 16 isoform 1 [Homo sa... 35 0.13
gi|7705696 thioredoxin domain containing 12 [Homo sapiens] 35 0.22
gi|18104959 thioredoxin domain containing 9 [Homo sapiens] 31 2.4
>gi|5803121 protein disulfide isomerase A5 [Homo sapiens]
Length = 519
Score = 1087 bits (2810), Expect = 0.0
Identities = 519/519 (100%), Positives = 519/519 (100%)
Query: 1 MARAGPAWLLLAIWVVLPSWLSSAKVSSLIERISDPKDLKKLLRTRNNVLVLYSKSEVAA 60
MARAGPAWLLLAIWVVLPSWLSSAKVSSLIERISDPKDLKKLLRTRNNVLVLYSKSEVAA
Sbjct: 1 MARAGPAWLLLAIWVVLPSWLSSAKVSSLIERISDPKDLKKLLRTRNNVLVLYSKSEVAA 60
Query: 61 ENHLRLLSTVAQAVKGQGTICWVDCGDAESRKLCKKMKVDLSPKDKKVELFHYQDGAFHT 120
ENHLRLLSTVAQAVKGQGTICWVDCGDAESRKLCKKMKVDLSPKDKKVELFHYQDGAFHT
Sbjct: 61 ENHLRLLSTVAQAVKGQGTICWVDCGDAESRKLCKKMKVDLSPKDKKVELFHYQDGAFHT 120
Query: 121 EYNRAVTFKSIVAFLKDPKGPPLWEEDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAP 180
EYNRAVTFKSIVAFLKDPKGPPLWEEDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAP
Sbjct: 121 EYNRAVTFKSIVAFLKDPKGPPLWEEDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAP 180
Query: 181 WCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLF 240
WCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLF
Sbjct: 181 WCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLF 240
Query: 241 QYDNYGSTAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMF 300
QYDNYGSTAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMF
Sbjct: 241 QYDNYGSTAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMF 300
Query: 301 HAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKN 360
HAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKN
Sbjct: 301 HAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKN 360
Query: 361 GEKYAVPVLRTKKKFLEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNFRETLKKKKHTLVM 420
GEKYAVPVLRTKKKFLEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNFRETLKKKKHTLVM
Sbjct: 361 GEKYAVPVLRTKKKFLEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNFRETLKKKKHTLVM 420
Query: 421 FYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYH 480
FYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYH
Sbjct: 421 FYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYH 480
Query: 481 YGKFAEKYDSDRTELGFTNYIRALREGDHERLGKKKEEL 519
YGKFAEKYDSDRTELGFTNYIRALREGDHERLGKKKEEL
Sbjct: 481 YGKFAEKYDSDRTELGFTNYIRALREGDHERLGKKKEEL 519
>gi|4758304 protein disulfide isomerase A4 [Homo sapiens]
Length = 645
Score = 138 bits (347), Expect = 1e-32
Identities = 84/232 (36%), Positives = 118/232 (50%), Gaps = 16/232 (6%)
Query: 274 EGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLA 333
E V L D +FD FV + +VL+ F+APWCGHCK+ PE+EK A L + D +A
Sbjct: 60 EENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILK-DKDPPIPVA 118
Query: 334 AVDATVNKALAERFHISEFPTLKYFKNGEKYAVPVLRTKKKF---LEWMQNPEAPPPPEP 390
+DAT LA RF +S +PT+K K G+ RT+++ + + P+ PPPE
Sbjct: 119 KIDATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEV 178
Query: 391 TWEEQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHF-TATADAFKDDRKI 449
T L L +NF E + LV FYAPWC HCKK+ P + A + K I
Sbjct: 179 T--------LVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPI 230
Query: 450 ACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELGFTNYI 501
A VD + DL ++ V GYPT + G+ Y+ R + G +Y+
Sbjct: 231 PLAKVDATAE--TDLAKRFDVSGYPTLKIFRKGR-PYDYNGPREKYGIVDYM 279
Score = 130 bits (327), Expect = 3e-30
Identities = 78/223 (34%), Positives = 117/223 (52%), Gaps = 13/223 (5%)
Query: 169 EEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGH-AVLAGMNVYSSEFENIKEEYSVRGF 227
++ +L+ FYAPWC CK+ P ++K A L+ + + ++ + + V G+
Sbjct: 78 DKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGY 137
Query: 228 PTICYFEKGRFLFQYDNYGS-TAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDF 286
PTI +KG+ + D GS T E+IV ++ +V + W LT E+F
Sbjct: 138 PTIKILKKGQAV---DYEGSRTQEEIVAKVR-------EVSQPDWTPPPEVTLVLTKENF 187
Query: 287 DQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAER 346
D+ V + +LV F+APWCGHCKK+ PE+EKAA+ L + LA VDAT LA+R
Sbjct: 188 DEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKEL-SKRSPPIPLAKVDATAETDLAKR 246
Query: 347 FHISEFPTLKYFKNGEKYAVPVLRTKKKFLEWMQNPEAPPPPE 389
F +S +PTLK F+ G Y R K +++M PP E
Sbjct: 247 FDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKE 289
Score = 65.5 bits (158), Expect = 1e-10
Identities = 31/89 (34%), Positives = 52/89 (58%), Gaps = 3/89 (3%)
Query: 276 GSVYHLTDEDFDQFVKE-HSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAA 334
G V + + FD V + VL+ F+APWCGHCK+++P + A+ G+ V+A
Sbjct: 525 GPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQ--KGLVIAK 582
Query: 335 VDATVNKALAERFHISEFPTLKYFKNGEK 363
+DAT N ++R+ + FPT+ + +G+K
Sbjct: 583 MDATANDVPSDRYKVEGFPTIYFAPSGDK 611
Score = 57.0 bits (136), Expect = 4e-08
Identities = 37/116 (31%), Positives = 53/116 (45%), Gaps = 4/116 (3%)
Query: 394 EQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKD-DRKIACA 452
+++ VL L NF + K L+ FYAPWC HCK+ P + A+ KD D I A
Sbjct: 59 KEENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVA 118
Query: 453 AVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELGFTNYIRALREGD 508
+D L + V GYPT G+ A Y+ RT+ +R + + D
Sbjct: 119 KIDAT--SASVLASRFDVSGYPTIKILKKGQ-AVDYEGSRTQEEIVAKVREVSQPD 171
Score = 55.8 bits (133), Expect = 9e-08
Identities = 35/115 (30%), Positives = 57/115 (49%), Gaps = 7/115 (6%)
Query: 127 TFKSIVAFLKDPKGPPLWEEDPGAKD---VVHLDSEKDFRRLLKKEEKPLLIMFYAPWCS 183
T + V K K P+ + P K+ V + K F ++ +K +LI FYAPWC
Sbjct: 497 TLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCG 556
Query: 184 MCKRMMPHFQKAATQLRGH--AVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKG 236
CK++ P + A + +G V+A M+ +++ + + Y V GFPTI + G
Sbjct: 557 HCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPS--DRYKVEGFPTIYFAPSG 609
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/134 (27%), Positives = 63/134 (47%), Gaps = 8/134 (5%)
Query: 389 EPTWEEQQTSVLHLVGDNFRE-TLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDR 447
+P + + V +VG F + KK L+ FYAPWC HCK++ P + + A +K +
Sbjct: 517 QPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQK 576
Query: 448 KIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYG--KFAEKYDSDRTELGFTNYIRALR 505
+ A +D N + V+G+PT ++ G K K++ +L ++
Sbjct: 577 GLVIAKMDAT--ANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDL---EHLSKFI 631
Query: 506 EGDHERLGKKKEEL 519
E +L + KEEL
Sbjct: 632 EEHATKLSRTKEEL 645
>gi|42794771 thioredoxin domain containing 5 isoform 1 precursor
[Homo sapiens]
Length = 432
Score = 132 bits (333), Expect = 6e-31
Identities = 107/384 (27%), Positives = 175/384 (45%), Gaps = 47/384 (12%)
Query: 140 GPPLWE----EDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKA 195
GPP + +DP +K HL + F ++ +MF+APWC C+R+ P +
Sbjct: 48 GPPAADGEDGQDPHSK---HLYTADMFTHGIQSAAH--FVMFFAPWCGHCQRLQPTWNDL 102
Query: 196 ATQLRG--HAVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTAEDIV 253
+ A + V + ++ VRG+PT+ F+ G+ +Y + +
Sbjct: 103 GDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQG-PRDFQTLE 161
Query: 254 EWL-----KNPQPPQPQV--PETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCG 306
W+ + P P+P+V P P +G +Y L+ +F+ V + + F APWCG
Sbjct: 162 NWMLQTLNEEPVTPEPEVEPPSAPELKQG--LYELSASNFELHVAQGDH-FIKFFAPWCG 218
Query: 307 HCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGEK--- 363
HCK + P +E+ A L E + + VD T + L + +PTL +F++G+K
Sbjct: 219 HCKALAPTWEQLALGL--EHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQ 276
Query: 364 ------------YAVPVL-RTKKKFLEWMQNPEAPP-PPEPTWEEQQTSVLHLVGDNFRE 409
Y L RT+ E + EAP EP E + +VL L +NF +
Sbjct: 277 YKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEP--EADKGTVLALTENNFDD 334
Query: 410 TLKKKKHTLVMFYAPWCPHCKKVIPHF-TATADAFKDDRKIACAAVDCVKDKNQDLCQQE 468
T+ + T + FYAPWC HCK + P + + F + A VDC ++N +C +
Sbjct: 335 TIAEGI-TFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN--ICSKY 391
Query: 469 AVKGYPTFHYYHYGKFAEKYDSDR 492
+V+GYPT + GK ++ R
Sbjct: 392 SVRGYPTLLLFRGGKKVSEHSGGR 415
Score = 110 bits (276), Expect = 2e-24
Identities = 68/234 (29%), Positives = 106/234 (45%), Gaps = 15/234 (6%)
Query: 280 HLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATV 339
HL D + ++ VMF APWCGHC++++P + + + D+ +A VD T
Sbjct: 64 HLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTA 123
Query: 340 NKALAERFHISEFPTLKYFKNGE---KYAVPVLRTKKKFLEWMQNP--EAPPPPEPTWE- 393
+ + + +PTLK FK G+ KY P R + WM E P PEP E
Sbjct: 124 HSDVCSAQGVRGYPTLKLFKPGQEAVKYQGP--RDFQTLENWMLQTLNEEPVTPEPEVEP 181
Query: 394 ----EQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKI 449
E + + L NF + + H + F+APWC HCK + P + A + +
Sbjct: 182 PSAPELKQGLYELSASNFELHVAQGDH-FIKFFAPWCGHCKALAPTWEQLALGLEHSETV 240
Query: 450 ACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELGFTNYIRA 503
VDC ++ +LC V+GYPT ++ GK ++Y R Y+ +
Sbjct: 241 KIGKVDCT--QHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVES 292
>gi|5031973 protein disulfide isomerase A6 [Homo sapiens]
Length = 440
Score = 124 bits (310), Expect = 3e-28
Identities = 78/227 (34%), Positives = 119/227 (52%), Gaps = 21/227 (9%)
Query: 152 DVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVY 211
DV+ L + +F R + + + L+ FYAPWC C+R+ P ++KAAT L+ + ++
Sbjct: 26 DVIEL-TPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVD-- 82
Query: 212 SSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTAEDIVEWLKNPQPPQPQVPETPW 271
+ + ++ +Y V+GFPTI F + + G T E IV+ + + V +
Sbjct: 83 ADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSAL--RQLVKDRLG 140
Query: 272 ADEGG---------------SVYHLTDEDFDQFVKEHSSV-LVMFHAPWCGHCKKMKPEF 315
GG V LTD+ FD+ V + V +V F+APWCGHCK ++PE+
Sbjct: 141 GRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEW 200
Query: 316 EKAAEALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGE 362
AA + + LAAVDATVN+ LA R+ I FPT+K F+ GE
Sbjct: 201 AAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGE 247
Score = 103 bits (257), Expect = 4e-22
Identities = 72/237 (30%), Positives = 112/237 (47%), Gaps = 27/237 (11%)
Query: 278 VYHLTDEDFDQFVKEHSSV-LVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVD 336
V LT +F++ V + S+ LV F+APWCGHC+++ PE++KAA AL + AVD
Sbjct: 27 VIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVK----VGAVD 82
Query: 337 ATVNKALAERFHISEFPTLKYF-------------KNGEKYAVPVLRTKKKFLEWMQNPE 383
A + +L ++ + FPT+K F + GE L ++ ++
Sbjct: 83 ADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGR 142
Query: 384 APPPPEPTWEEQQTS----VLHLVGDNF-RETLKKKKHTLVMFYAPWCPHCKKVIPHFTA 438
+ +S V+ L D+F + L + +V FYAPWC HCK + P + A
Sbjct: 143 SGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAA 202
Query: 439 TADAFKDDR--KIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRT 493
A K+ K+ AAVD NQ L + ++G+PT + G+ YD RT
Sbjct: 203 AASEVKEQTKGKVKLAAVDAT--VNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRT 257
Score = 64.7 bits (156), Expect = 2e-10
Identities = 41/122 (33%), Positives = 61/122 (50%), Gaps = 13/122 (10%)
Query: 151 KDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAAT----QLRGHAVLA 206
KDV+ L + + +L E+ ++ FYAPWC CK + P + AA+ Q +G LA
Sbjct: 160 KDVIELTDDSFDKNVLDSEDV-WMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLA 218
Query: 207 GMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTAEDIVE-----WLKNPQP 261
++ ++ + Y +RGFPTI F+KG YD G T DIV + N P
Sbjct: 219 AVDATVNQV--LASRYGIRGFPTIKIFQKGESPVDYDG-GRTRSDIVSRALDLFSDNAPP 275
Query: 262 PQ 263
P+
Sbjct: 276 PE 277
Score = 62.4 bits (150), Expect = 1e-09
Identities = 45/118 (38%), Positives = 60/118 (50%), Gaps = 7/118 (5%)
Query: 399 VLHLVGDNF-RETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCV 457
V+ L NF RE ++ LV FYAPWC HC+++ P + A A KD K+ AVD
Sbjct: 27 VIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKV--GAVDA- 83
Query: 458 KDKNQDLCQQEAVKGYPTFHYYHYGK-FAEKYDSDRT-ELGFTNYIRALREGDHERLG 513
DK+ L Q V+G+PT + K E Y RT E + ALR+ +RLG
Sbjct: 84 -DKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLG 140
>gi|224493972 thioredoxin domain containing 5 isoform 3 [Homo
sapiens]
Length = 324
Score = 114 bits (285), Expect = 2e-25
Identities = 87/294 (29%), Positives = 139/294 (47%), Gaps = 36/294 (12%)
Query: 224 VRGFPTICYFEKGRFLFQYDNYGSTAEDIVEWL-----KNPQPPQPQV--PETPWADEGG 276
VRG+PT+ F+ G+ +Y + + W+ + P P+P+V P P +G
Sbjct: 25 VRGYPTLKLFKPGQEAVKYQG-PRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQG- 82
Query: 277 SVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVD 336
+Y L+ +F+ V + + F APWCGHCK + P +E+ A L E + + VD
Sbjct: 83 -LYELSASNFELHVAQGDH-FIKFFAPWCGHCKALAPTWEQLALGL--EHSETVKIGKVD 138
Query: 337 ATVNKALAERFHISEFPTLKYFKNGEK---------------YAVPVL-RTKKKFLEWMQ 380
T + L + +PTL +F++G+K Y L RT+ E +
Sbjct: 139 CTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVT 198
Query: 381 NPEAPP-PPEPTWEEQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHF-TA 438
EAP EP E + +VL L +NF +T+ + T + FYAPWC HCK + P +
Sbjct: 199 PSEAPVLAAEP--EADKGTVLALTENNFDDTI-AEGITFIKFYAPWCGHCKTLAPTWEEL 255
Query: 439 TADAFKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDR 492
+ F + A VDC ++N +C + +V+GYPT + GK ++ R
Sbjct: 256 SKKEFPGLAGVKIAEVDCTAERN--ICSKYSVRGYPTLLLFRGGKKVSEHSGGR 307
Score = 91.3 bits (225), Expect = 2e-18
Identities = 58/202 (28%), Positives = 99/202 (49%), Gaps = 17/202 (8%)
Query: 175 IMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYFE 234
I F+APWC CK + P +++ A L + V ++ + VRG+PT+ +F
Sbjct: 102 IKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFR 161
Query: 235 KGRFLFQYD---NYGSTAEDIVEWLKNPQ---------PPQPQVPETPWADEGGSVYHLT 282
G+ + QY + S E + L+ + P + P AD+ G+V LT
Sbjct: 162 DGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADK-GTVLALT 220
Query: 283 DEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGV-LAAVDATVNK 341
+ +FD + E + F+APWCGHCK + P +E+ ++ +GV +A VD T +
Sbjct: 221 ENNFDDTIAE-GITFIKFYAPWCGHCKTLAPTWEELSKKEF--PGLAGVKIAEVDCTAER 277
Query: 342 ALAERFHISEFPTLKYFKNGEK 363
+ ++ + +PTL F+ G+K
Sbjct: 278 NICSKYSVRGYPTLLLFRGGKK 299
Score = 80.1 bits (196), Expect = 4e-15
Identities = 54/187 (28%), Positives = 82/187 (43%), Gaps = 15/187 (8%)
Query: 327 DSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGE---KYAVPVLRTKKKFLEWMQNP- 382
D+ +A VD T + + + +PTLK FK G+ KY P R + WM
Sbjct: 3 DAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGP--RDFQTLENWMLQTL 60
Query: 383 -EAPPPPEPTWE-----EQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHF 436
E P PEP E E + + L NF + + H + F+APWC HCK + P +
Sbjct: 61 NEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDH-FIKFFAPWCGHCKALAPTW 119
Query: 437 TATADAFKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELG 496
A + + VDC ++ +LC V+GYPT ++ GK ++Y R
Sbjct: 120 EQLALGLEHSETVKIGKVDCT--QHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLES 177
Query: 497 FTNYIRA 503
Y+ +
Sbjct: 178 LREYVES 184
>gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo
sapiens]
Length = 793
Score = 111 bits (277), Expect = 2e-24
Identities = 88/361 (24%), Positives = 166/361 (45%), Gaps = 44/361 (12%)
Query: 169 EEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFP 228
+++P L+ F+APWC C+ ++P ++A+ L G ++ + E + Y+++ +P
Sbjct: 467 DKEPWLVDFFAPWCPPCRALLPELRRASNLLYGQLKFGTLD--CTVHEGLCNMYNIQAYP 524
Query: 229 TICYFEKGRFLFQYDNYGSTAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDFDQ 288
T F + + +Y+ + S AE I+E++++ P SV LT F++
Sbjct: 525 TTVVFNQSN-IHEYEGHHS-AEQILEFIEDLMNP--------------SVVSLTPTTFNE 568
Query: 289 FV--KEHSSV-LVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAE 345
V ++H+ V +V F++PWC C+ + PE+++ A L G + + ++D +
Sbjct: 569 LVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLIN----VGSIDCQQYHSFCA 624
Query: 346 RFHISEFPTLKYF--KNGEKYAVPVLRTKKKFLEWMQNPEAPPPPEPTWEEQQTSVLHLV 403
+ ++ +P +++F K+ + Y + W ++ + + Q ++ L
Sbjct: 625 QENVQRYPEIRFFPPKSNKAYHY------HSYNGWNRDAYSLRIWGLGFLPQVST--DLT 676
Query: 404 GDNFRE-TLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQ 462
F E L+ K H ++ FYAPWC C+ P F A K K+ VDC
Sbjct: 677 PQTFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELLARMIKG--KVKAGKVDC--QAYA 732
Query: 463 DLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELGFTNYIRALREGDHERL---GKK-KEE 518
CQ+ ++ YPT +Y Y + + ++ I AL E L GK+ K+E
Sbjct: 733 QTCQKAGIRAYPTVKFYFYERAKRNFQEEQINTRDAKAIAALISEKLETLRNQGKRNKDE 792
Query: 519 L 519
L
Sbjct: 793 L 793
Score = 68.2 bits (165), Expect = 2e-11
Identities = 56/242 (23%), Positives = 102/242 (42%), Gaps = 32/242 (13%)
Query: 121 EYNRAVTFKSIVAFLKDPKGPPLWEEDPGAKDVVHLDSEKDFRRLL--KKEEKPLLIMFY 178
EY + + I+ F++D P + P F L+ +K + ++ FY
Sbjct: 536 EYEGHHSAEQILEFIEDLMNPSVVSLTPTT-----------FNELVTQRKHNEVWMVDFY 584
Query: 179 APWCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYFE-KGR 237
+PWC C+ +MP +++ A L G + ++ ++ + + +V+ +P I +F K
Sbjct: 585 SPWCHPCQVLMPEWKRMARTLTGLINVGSIDC--QQYHSFCAQENVQRYPEIRFFPPKSN 642
Query: 238 FLFQYDNYGSTAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVL 297
+ Y +Y D PQV LT + F + V + +
Sbjct: 643 KAYHYHSYNGWNRDAYSLRIWGLGFLPQVSTD-----------LTPQTFSEKVLQGKNHW 691
Query: 298 VM-FHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAERFHISEFPTLK 356
V+ F+APWCG C+ PEFE A + G+ + VD ++ I +PT+K
Sbjct: 692 VIDFYAPWCGPCQNFAPEFELLARMIKGKVKA----GKVDCQAYAQTCQKAGIRAYPTVK 747
Query: 357 YF 358
++
Sbjct: 748 FY 749
Score = 43.1 bits (100), Expect = 6e-04
Identities = 24/82 (29%), Positives = 38/82 (46%), Gaps = 4/82 (4%)
Query: 419 VMFYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHY 478
V FY+P C HC + P + A D + AV+C D+ LC+ + V YP+
Sbjct: 151 VNFYSPGCSHCHDLAPTWRDFAKEV--DGLLRIGAVNCGDDRM--LCRMKGVNSYPSLFI 206
Query: 479 YHYGKFAEKYDSDRTELGFTNY 500
+ G KY DR++ ++
Sbjct: 207 FRSGMAPVKYHGDRSKESLVSF 228
Score = 38.1 bits (87), Expect = 0.020
Identities = 22/89 (24%), Positives = 40/89 (44%), Gaps = 4/89 (4%)
Query: 273 DEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVL 332
D+ + L +FD V V F++P C HC + P + A+ E D +
Sbjct: 126 DDDPEIITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAK----EVDGLLRI 181
Query: 333 AAVDATVNKALAERFHISEFPTLKYFKNG 361
AV+ ++ L ++ +P+L F++G
Sbjct: 182 GAVNCGDDRMLCRMKGVNSYPSLFIFRSG 210
>gi|94966757 protein disulfide isomerase A2 [Homo sapiens]
Length = 525
Score = 86.3 bits (212), Expect = 6e-17
Identities = 48/131 (36%), Positives = 74/131 (56%), Gaps = 14/131 (10%)
Query: 260 QPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAA 319
+PP+ ++P+ E G + L+ ++EH ++LV F+APWCGHC+ + PE+ KAA
Sbjct: 32 EPPEEEIPK-----EDG-ILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAA 85
Query: 320 EALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNG-----EKYAVPVLRTKKK 374
L E+ LA VD + LAE F ++E+PTLK+F+NG E+Y P R +
Sbjct: 86 AVLAAES-MVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGP--RDAEG 142
Query: 375 FLEWMQNPEAP 385
EW++ P
Sbjct: 143 IAEWLRRRVGP 153
Score = 69.3 bits (168), Expect = 8e-12
Identities = 66/233 (28%), Positives = 105/233 (45%), Gaps = 21/233 (9%)
Query: 174 LIMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRG--FPTI- 230
L++F + + ++ F +AA + RG + ++V +++ E++ + + ++ PT+
Sbjct: 279 LLLFVNQTLAAHRELLAGFGEAAPRFRGQVLFVVVDV-AADNEHVLQYFGLKAEAAPTLR 337
Query: 231 -CYFEKGRFLFQYDNYGSTAEDIVEW----LKNPQPPQPQVPETPWADEGGSVYHLTDED 285
E + D TA I + L P E P + V L ++
Sbjct: 338 LVNLETTKKYAPVDGGPVTAASITAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKN 397
Query: 286 FDQFV-KEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALA 344
F+Q E +V V F+APWC HCK+M P +E AE D ++A +DAT N+
Sbjct: 398 FEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDI--IIAELDATANE--L 453
Query: 345 ERFHISEFPTLKYFKNG------EKYAVPVLRTKKKFLE-WMQNPEAPPPPEP 390
+ F + FPTLKYF G E + L T KFL+ P PP EP
Sbjct: 454 DAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFLDNGGVLPTEEPPEEP 506
Score = 65.1 bits (157), Expect = 1e-10
Identities = 67/248 (27%), Positives = 113/248 (45%), Gaps = 34/248 (13%)
Query: 48 NVLVLYSKSEVAAENHLRLLSTVAQAV---KGQGTICWVD-CGDAESRKLCKKMKVDLSP 103
N L+L+ +AA H LL+ +A +GQ VD D E +K + +P
Sbjct: 277 NHLLLFVNQTLAA--HRELLAGFGEAAPRFRGQVLFVVVDVAADNEHVLQYFGLKAEAAP 334
Query: 104 KDKKVEL-----FHYQDG-----AFHTEYNRAVTFKSIVAFLKDPKGPPLWEEDPGAKDV 153
+ V L + DG A T + AV + +L + PP W++ P K +
Sbjct: 335 TLRLVNLETTKKYAPVDGGPVTAASITAFCHAVLNGQVKPYLLSQEIPPDWDQRP-VKTL 393
Query: 154 VHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGH--AVLAGMNVY 211
V K+F ++ E K + + FYAPWC+ CK M P ++ A + + H ++A ++
Sbjct: 394 VG----KNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDAT 449
Query: 212 SSEFENIKEEYSVRGFPTICYFE--KGRFLFQYDNYGSTAEDIVEWLKN----PQPPQPQ 265
++E + ++V GFPT+ YF GR + +Y + E ++L N P P+
Sbjct: 450 ANEL----DAFAVHGFPTLKYFPAGPGRKVIEYKS-TRDLETFSKFLDNGGVLPTEEPPE 504
Query: 266 VPETPWAD 273
P P+ +
Sbjct: 505 EPAAPFPE 512
Score = 63.2 bits (152), Expect = 6e-10
Identities = 38/115 (33%), Positives = 58/115 (50%), Gaps = 9/115 (7%)
Query: 390 PTWEEQQTSVLHLVGDNFRET-LKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRK 448
P W+ Q V LVG NF + + K+ V FYAPWC HCK++ P + A A+ ++D
Sbjct: 383 PDWD--QRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHED 440
Query: 449 IACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHY--GKFAEKYDSDRTELGFTNYI 501
I A +D ++ AV G+PT Y+ G+ +Y S R F+ ++
Sbjct: 441 IIIAELDATANE----LDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFL 491
Score = 59.3 bits (142), Expect = 8e-09
Identities = 38/129 (29%), Positives = 58/129 (44%), Gaps = 4/129 (3%)
Query: 136 KDPKGPPLWEEDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKA 195
+ P P EE P ++ L + L +E LL+ FYAPWC C+ + P + KA
Sbjct: 27 RSPSEEPPEEEIPKEDGILVLS--RHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKA 84
Query: 196 ATQLRGHAVLAGM-NVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYG-STAEDIV 253
A L +++ + V + EE+ V +PT+ +F G + G AE I
Sbjct: 85 AAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIA 144
Query: 254 EWLKNPQPP 262
EWL+ P
Sbjct: 145 EWLRRRVGP 153
Score = 52.8 bits (125), Expect = 8e-07
Identities = 37/131 (28%), Positives = 57/131 (43%), Gaps = 8/131 (6%)
Query: 378 WMQNPEAPPPPEPTWEEQ---QTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIP 434
W Q A P E EE+ + +L L L++ LV FYAPWC HC+ + P
Sbjct: 20 WGQEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAP 79
Query: 435 HFT-ATADAFKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGK--FAEKYDSD 491
++ A A + + A VD ++L ++ V YPT ++ G E+Y
Sbjct: 80 EYSKAAAVLAAESMVVTLAKVD--GPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGP 137
Query: 492 RTELGFTNYIR 502
R G ++R
Sbjct: 138 RDAEGIAEWLR 148
>gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo
sapiens]
Length = 508
Score = 76.6 bits (187), Expect = 5e-14
Identities = 38/90 (42%), Positives = 55/90 (61%), Gaps = 1/90 (1%)
Query: 273 DEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVL 332
+E V L +F + + H +LV F+APWCGHCK + PE+ KAA L E S L
Sbjct: 21 EEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEG-SEIRL 79
Query: 333 AAVDATVNKALAERFHISEFPTLKYFKNGE 362
A VDAT LA+++ + +PT+K+F+NG+
Sbjct: 80 AKVDATEESDLAQQYGVRGYPTIKFFRNGD 109
Score = 72.8 bits (177), Expect = 7e-13
Identities = 41/112 (36%), Positives = 59/112 (52%), Gaps = 5/112 (4%)
Query: 394 EQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFK-DDRKIACA 452
E++ VL L NF E L K+ LV FYAPWC HCK + P + A K + +I A
Sbjct: 21 EEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLA 80
Query: 453 AVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFA--EKYDSDRTELGFTNYIR 502
VD ++ DL QQ V+GYPT ++ G A ++Y + R N+++
Sbjct: 81 KVDATEE--SDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLK 130
Score = 68.6 bits (166), Expect = 1e-11
Identities = 41/117 (35%), Positives = 62/117 (52%), Gaps = 3/117 (2%)
Query: 148 PGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGH-AVLA 206
P +D V + + +F L K LL+ FYAPWC CK + P + KAA +L+ + +
Sbjct: 20 PEEEDHVLVLRKSNFAEALAAH-KYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIR 78
Query: 207 GMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYD-NYGSTAEDIVEWLKNPQPP 262
V ++E ++ ++Y VRG+PTI +F G + G A+DIV WLK P
Sbjct: 79 LAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRTGP 135
Score = 63.9 bits (154), Expect = 3e-10
Identities = 56/206 (27%), Positives = 87/206 (42%), Gaps = 25/206 (12%)
Query: 315 FEKAAEALHGE----------ADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGEKY 364
F+ AAE+ G+ D+ +L + A R E KY E+
Sbjct: 275 FKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEEL 334
Query: 365 -AVPVLRTKKKFLEWMQNPEAPPPPEPT-WEEQQTSVLHLVGDNFRET-LKKKKHTLVMF 421
A + +FLE P P W++Q VL VG NF + +KK+ V F
Sbjct: 335 TAERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVL--VGKNFEDVAFDEKKNVFVEF 392
Query: 422 YAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQQEAVK--GYPTFHYY 479
YAPWC HCK++ P + + +KD I A +D + + EAVK +PT ++
Sbjct: 393 YAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTAN------EVEAVKVHSFPTLKFF 446
Query: 480 --HYGKFAEKYDSDRTELGFTNYIRA 503
+ Y+ +RT GF ++ +
Sbjct: 447 PASADRTVIDYNGERTLDGFKKFLES 472
Score = 63.2 bits (152), Expect = 6e-10
Identities = 61/239 (25%), Positives = 107/239 (44%), Gaps = 27/239 (11%)
Query: 158 SEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFEN 217
+E+ ++ E K +++F S + +F+ AA +G + ++ ++ +
Sbjct: 241 TEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQR 300
Query: 218 IKEEYSVRGFPT----ICYFEKGRFLFQYDNYGSTAEDIVEW----LKNPQPPQPQVPET 269
I E + ++ + E+ ++ ++ TAE I E+ L+ P E
Sbjct: 301 ILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQEL 360
Query: 270 PWADEGGSVYHLTDEDFDQFV-KEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADS 328
P + V L ++F+ E +V V F+APWCGHCK++ P ++K E +
Sbjct: 361 PEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENI 420
Query: 329 SGVLAAVDATVNKALAERFHISEFPTLKYFK----------NGEKYAVPVLRTKKKFLE 377
V+A +D+T N+ A + H FPTLK+F NGE+ L KKFLE
Sbjct: 421 --VIAKMDSTANEVEAVKVH--SFPTLKFFPASADRTVIDYNGER----TLDGFKKFLE 471
>gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens]
Length = 505
Score = 75.5 bits (184), Expect = 1e-13
Identities = 38/89 (42%), Positives = 54/89 (60%), Gaps = 7/89 (7%)
Query: 278 VYHLTDEDFDQFVKEHSS---VLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAA 334
V LTD++F+ + + S +LV F APWCGHCK++ PE+E AA L G LA
Sbjct: 27 VLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVP----LAK 82
Query: 335 VDATVNKALAERFHISEFPTLKYFKNGEK 363
VD T N ++ +S +PTLK F++GE+
Sbjct: 83 VDCTANTNTCNKYGVSGYPTLKIFRDGEE 111
Score = 68.9 bits (167), Expect = 1e-11
Identities = 53/174 (30%), Positives = 82/174 (47%), Gaps = 20/174 (11%)
Query: 150 AKDVVHLDSEKDFRRLLKKEEKPLLIM-FYAPWCSMCKRMMPHFQKAATQLRGHAVLAGM 208
A DV+ L + R+ L+++ F+APWC CKR+ P ++ AAT+L+G LA +
Sbjct: 24 ASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKV 83
Query: 209 NVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTAEDIVEWLKNPQPPQPQVPE 268
+ ++ N +Y V G+PT+ F G YD TA+ IV LK P
Sbjct: 84 DCTAN--TNTCNKYGVSGYPTLKIFRDGEEAGAYDG-PRTADGIVSHLKKQAGP------ 134
Query: 269 TPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEAL 322
SV T+E+F +F+ + + +V F + + EF KAA L
Sbjct: 135 -------ASVPLRTEEEFKKFISDKDASIVGF---FDDSFSEAHSEFLKAASNL 178
Score = 68.9 bits (167), Expect = 1e-11
Identities = 38/109 (34%), Positives = 53/109 (48%), Gaps = 7/109 (6%)
Query: 397 TSVLHLVGDNFRETLKKKKHT---LVMFYAPWCPHCKKVIPHFTATADAFKDDRKIACAA 453
+ VL L DNF + LV F+APWC HCK++ P + A A K + A
Sbjct: 25 SDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKG--IVPLAK 82
Query: 454 VDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELGFTNYIR 502
VDC N + C + V GYPT + G+ A YD RT G ++++
Sbjct: 83 VDCT--ANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLK 129
Score = 66.6 bits (161), Expect = 5e-11
Identities = 40/117 (34%), Positives = 62/117 (52%), Gaps = 9/117 (7%)
Query: 276 GSVYHLTDEDFDQFVK-EHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAA 334
G V + E+FD+ V E+ VL+ F+APWCGHCK ++P++++ E L D + V+A
Sbjct: 376 GPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKL--SKDPNIVIAK 433
Query: 335 VDATVNKALAERFHISEFPTLKYFKNGEKYAVPVL----RTKKKFLEWMQNPEAPPP 387
+DAT N + + + FPT+ YF K P R F+ ++Q PP
Sbjct: 434 MDATAND-VPSPYEVRGFPTI-YFSPANKKLNPKKYEGGRELSDFISYLQREATNPP 488
Score = 63.9 bits (154), Expect = 3e-10
Identities = 99/464 (21%), Positives = 178/464 (38%), Gaps = 85/464 (18%)
Query: 71 AQAVKGQGTICWVDCGDAESRKLCKKMKVDLSPKDKKVELFHYQDGAFHTEYNRAVTFKS 130
A +KG + VDC + C K V P K ++DG Y+ T
Sbjct: 71 ATRLKGIVPLAKVDC--TANTNTCNKYGVSGYPTLKI-----FRDGEEAGAYDGPRTADG 123
Query: 131 IVAFLKDPKGPPLWEEDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMP 190
IV+ LK GP V L +E++F++ + ++ ++ F +
Sbjct: 124 IVSHLKKQAGPAS----------VPLRTEEEFKKFISDKDASIVGFFDDSF----SEAHS 169
Query: 191 HFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTAE 250
F KAA+ LR + A NV E++ EY G +G LF+ + + E
Sbjct: 170 EFLKAASNLRDNYRFAHTNV-----ESLVNEYDDNG--------EGIILFRPSHLTNKFE 216
Query: 251 DIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAP------- 303
D + ++ + + G H+T+++ D + +L+ ++
Sbjct: 217 DKTVAYTEQKMTSGKIKKFIQENIFGICPHMTEDNKDLI--QGKDLLIAYYDVDYEKNAK 274
Query: 304 ----WCGHCKKMKPEFEKAAEALH----------------GEADSSGVLAAVDATVNKAL 343
W + +F A L+ G ++G + V + A
Sbjct: 275 GSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVV--AIRTAK 332
Query: 344 AERFHISEFPTLKYFKNGEKYAVPVLRTKKKFLE--WMQNPEAPPPPEPTWEEQQTSVLH 401
E+F + E ++ ++G + ++FL+ + N + EP E V
Sbjct: 333 GEKFVMQE----EFSRDG--------KALERFLQDYFDGNLKRYLKSEPIPESNDGPVKV 380
Query: 402 LVGDNFRETLKKK-KHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDK 460
+V +NF E + + K L+ FYAPWC HCK + P + + D I A +D +
Sbjct: 381 VVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATAN- 439
Query: 461 NQDLCQQEAVKGYPTFHYYHYGK--FAEKYDSDRTELGFTNYIR 502
D+ V+G+PT ++ K +KY+ R F +Y++
Sbjct: 440 --DVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQ 481
Score = 59.7 bits (143), Expect = 6e-09
Identities = 40/134 (29%), Positives = 63/134 (47%), Gaps = 11/134 (8%)
Query: 139 KGPPLWEEDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQ 198
K P+ E + G VV ++ F ++ E K +LI FYAPWC CK + P +++ +
Sbjct: 366 KSEPIPESNDGPVKVVVAEN---FDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEK 422
Query: 199 LR--GHAVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNY--GSTAEDIVE 254
L + V+A M+ +++ + Y VRGFPTI YF Y G D +
Sbjct: 423 LSKDPNIVIAKMDATAND---VPSPYEVRGFPTI-YFSPANKKLNPKKYEGGRELSDFIS 478
Query: 255 WLKNPQPPQPQVPE 268
+L+ P + E
Sbjct: 479 YLQREATNPPVIQE 492
>gi|151101292 thioredoxin domain containing 1 [Homo sapiens]
Length = 280
Score = 61.6 bits (148), Expect = 2e-09
Identities = 39/115 (33%), Positives = 63/115 (54%), Gaps = 6/115 (5%)
Query: 270 PWAD-EGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADS 328
PW +V +TDE++ + ++ ++ F+APWC C+ ++PE+E AE GE D
Sbjct: 22 PWTHGRRSNVRVITDENWRELLE--GDWMIEFYAPWCPACQNLQPEWESFAE--WGE-DL 76
Query: 329 SGVLAAVDATVNKALAERFHISEFPTLKYFKNGEKYAVPVLRTKKKFLEWMQNPE 383
+A VD T L+ RF I+ PT+ + K+GE RTKK F+ ++ + E
Sbjct: 77 EVNIAKVDVTEQPGLSGRFIITALPTIYHCKDGEFRRYQGPRTKKDFINFISDKE 131
Score = 50.4 bits (119), Expect = 4e-06
Identities = 31/112 (27%), Positives = 59/112 (52%), Gaps = 6/112 (5%)
Query: 390 PTWEEQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKI 449
P ++++V + +N+RE L+ ++ FYAPWCP C+ + P + + A+ + +D ++
Sbjct: 22 PWTHGRRSNVRVITDENWRELLEGD--WMIEFYAPWCPACQNLQPEWESFAE-WGEDLEV 78
Query: 450 ACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELGFTNYI 501
A VD + L + + PT ++ G+F +Y RT+ F N+I
Sbjct: 79 NIAKVDVTEQPG--LSGRFIITALPTIYHCKDGEF-RRYQGPRTKKDFINFI 127
Score = 38.9 bits (89), Expect = 0.011
Identities = 25/91 (27%), Positives = 46/91 (50%), Gaps = 6/91 (6%)
Query: 149 GAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGHAV-LAG 207
G + V + +++++R LL E +I FYAPWC C+ + P ++ A V +A
Sbjct: 26 GRRSNVRVITDENWRELL---EGDWMIEFYAPWCPACQNLQPEWESFAEWGEDLEVNIAK 82
Query: 208 MNVYSSEFENIKEEYSVRGFPTICYFEKGRF 238
++V +E + + + PTI + + G F
Sbjct: 83 VDV--TEQPGLSGRFIITALPTIYHCKDGEF 111
>gi|38505222 thioredoxin domain containing 10 [Homo sapiens]
Length = 454
Score = 58.9 bits (141), Expect = 1e-08
Identities = 37/120 (30%), Positives = 57/120 (47%), Gaps = 8/120 (6%)
Query: 284 EDFDQFVKEHSSV---LVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVN 340
ED D+ KE+ + LV F+APWCGHCKK++P + + + S + +DAT
Sbjct: 29 EDLDESFKENRNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMK-SIGSPVKVGKMDATSY 87
Query: 341 KALAERFHISEFPTLKYFKNGEKYAVPVLRTKKKFLEWMQNPEA----PPPPEPTWEEQQ 396
++A F + +PT+K K Y RTK +E+ P P + +E Q
Sbjct: 88 SSIASEFGVRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQQMFEHMQ 147
Score = 50.4 bits (119), Expect = 4e-06
Identities = 28/84 (33%), Positives = 47/84 (55%), Gaps = 5/84 (5%)
Query: 174 LIMFYAPWCSMCKRMMPHFQKAATQLR--GHAVLAGMNVYSSEFENIKEEYSVRGFPTIC 231
L+ FYAPWC CK++ P + + +++ G V G + ++ + +I E+ VRG+PTI
Sbjct: 45 LVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVG-KMDATSYSSIASEFGVRGYPTIK 103
Query: 232 YFEKGRFLFQYDNYGSTAEDIVEW 255
KG + Y T +DI+E+
Sbjct: 104 LL-KGDLAYNYRG-PRTKDDIIEF 125
Score = 40.0 bits (92), Expect = 0.005
Identities = 27/94 (28%), Positives = 41/94 (43%), Gaps = 7/94 (7%)
Query: 405 DNFRETLKKKKHT---LVMFYAPWCPHCKKVIPHFTATADAFKD-DRKIACAAVDCVKDK 460
++ E+ K+ ++ LV FYAPWC HCKK+ P + K + +D
Sbjct: 29 EDLDESFKENRNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDAT--S 86
Query: 461 NQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTE 494
+ + V+GYPT G A Y RT+
Sbjct: 87 YSSIASEFGVRGYPTIKLLK-GDLAYNYRGPRTK 119
>gi|52487191 thioredoxin domain containing 4 (endoplasmic reticulum)
[Homo sapiens]
Length = 406
Score = 58.5 bits (140), Expect = 1e-08
Identities = 29/83 (34%), Positives = 47/83 (56%), Gaps = 2/83 (2%)
Query: 281 LTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSG--VLAAVDAT 338
L E+ D+ + LV F+A WC + + P FE+A++ + E + V A VD
Sbjct: 34 LDTENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCD 93
Query: 339 VNKALAERFHISEFPTLKYFKNG 361
+ +A+R+ IS++PTLK F+NG
Sbjct: 94 QHSDIAQRYRISKYPTLKLFRNG 116
Score = 53.5 bits (127), Expect = 5e-07
Identities = 32/111 (28%), Positives = 51/111 (45%), Gaps = 7/111 (6%)
Query: 397 TSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKD----DRKIACA 452
T + L +N E L LV FYA WC + + P F +D K+ + ++ A
Sbjct: 29 TEITSLDTENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFA 88
Query: 453 AVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEK-YDSDRTELGFTNYIR 502
VDC D++ D+ Q+ + YPT + G ++ Y R+ +YIR
Sbjct: 89 RVDC--DQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIR 137
Score = 37.0 bits (84), Expect = 0.044
Identities = 22/100 (22%), Positives = 45/100 (45%), Gaps = 6/100 (6%)
Query: 144 WEEDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGHA 203
W P ++ LD+E + +L + L + FYA WC + + P F++A+ ++
Sbjct: 22 WVFTPVTTEITSLDTE-NIDEILNNADVAL-VNFYADWCRFSQMLHPIFEEASDVIKEEF 79
Query: 204 VLAGMNVYS----SEFENIKEEYSVRGFPTICYFEKGRFL 239
V++ + +I + Y + +PT+ F G +
Sbjct: 80 PNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMM 119
>gi|145580631 quiescin Q6 sulfhydryl oxidase 2 [Homo sapiens]
Length = 698
Score = 57.4 bits (137), Expect = 3e-08
Identities = 30/90 (33%), Positives = 47/90 (52%), Gaps = 3/90 (3%)
Query: 418 LVMFYAPWCPHCKKVIPHFTATADAFKD-DRKIACAAVDCVKDKNQDLCQQEAVKGYPTF 476
LV FY+ WC HC P + A A +D I AA+DC+++KNQ +C + YPTF
Sbjct: 83 LVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDIHFYPTF 142
Query: 477 HYYHYGKFAEKYDSDRTELGFTNYIRALRE 506
Y+ F +++ + G +R +R+
Sbjct: 143 RYFK--AFTKEFTTGENFKGPDRELRTVRQ 170
Score = 46.2 bits (108), Expect = 7e-05
Identities = 43/155 (27%), Positives = 68/155 (43%), Gaps = 26/155 (16%)
Query: 271 WADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSG 330
W + GSV T ++ LV F++ WCGHC P + A + A +
Sbjct: 64 WVLDSGSVRGAT-------ANSSAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIR 116
Query: 331 VLAAVDA--TVNKALAERFHISEFPTLKYFK-------NGEKYAVP--VLRT-KKKFLEW 378
V AA+D N+A+ + I +PT +YFK GE + P LRT ++ +++
Sbjct: 117 V-AALDCMEEKNQAVCHDYDIHFYPTFRYFKAFTKEFTTGENFKGPDRELRTVRQTMIDF 175
Query: 379 MQN------PEAPPPPEPTWEEQQTSVLHLVGDNF 407
+QN P A P +P S+L G ++
Sbjct: 176 LQNHTEGSRPPACPRLDPIQPSDVLSLLDNRGSHY 210
Score = 34.3 bits (77), Expect = 0.28
Identities = 16/64 (25%), Positives = 31/64 (48%), Gaps = 3/64 (4%)
Query: 174 LIMFYAPWCSMCKRMMPHFQKAATQLRGHAV---LAGMNVYSSEFENIKEEYSVRGFPTI 230
L+ FY+ WC C P ++ A +R A +A ++ + + + +Y + +PT
Sbjct: 83 LVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDIHFYPTF 142
Query: 231 CYFE 234
YF+
Sbjct: 143 RYFK 146
>gi|21361403 thioredoxin 2 precursor [Homo sapiens]
Length = 166
Score = 55.8 bits (133), Expect = 9e-08
Identities = 29/76 (38%), Positives = 40/76 (52%), Gaps = 4/76 (5%)
Query: 287 DQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAER 346
D+ V + V+V FHA WCG CK + P EK HG+ V+A VD + LA
Sbjct: 72 DRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKV----VMAKVDIDDHTDLAIE 127
Query: 347 FHISEFPTLKYFKNGE 362
+ +S PT+ KNG+
Sbjct: 128 YEVSAVPTVLAMKNGD 143
Score = 46.6 bits (109), Expect = 6e-05
Identities = 21/76 (27%), Positives = 39/76 (51%), Gaps = 2/76 (2%)
Query: 161 DFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKE 220
DF+ + E P+++ F+A WC CK + P +K + G V+A +++ + ++
Sbjct: 69 DFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDI--DDHTDLAI 126
Query: 221 EYSVRGFPTICYFEKG 236
EY V PT+ + G
Sbjct: 127 EYEVSAVPTVLAMKNG 142
Score = 31.2 bits (69), Expect = 2.4
Identities = 26/96 (27%), Positives = 41/96 (42%), Gaps = 9/96 (9%)
Query: 404 GDNFRETLKKKKHTLVM-FYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQ 462
G +F++ + + +V+ F+A WC CK + P K K+ A VD D +
Sbjct: 67 GPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKM--VAKQHGKVVMAKVDI--DDHT 122
Query: 463 DLCQQEAVKGYPTFHYYHYGKFAEKY----DSDRTE 494
DL + V PT G +K+ D D+ E
Sbjct: 123 DLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLE 158
>gi|51873067 quiescin Q6 sulfhydryl oxidase 1 isoform b [Homo
sapiens]
Length = 604
Score = 47.4 bits (111), Expect = 3e-05
Identities = 36/118 (30%), Positives = 56/118 (47%), Gaps = 17/118 (14%)
Query: 294 SSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDAT--VNKALAERFHISE 351
S+ V F A WCGHC P ++ AE + + LAA+D N A+ F+I
Sbjct: 59 SAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPAL-YLAALDCAEETNSAVCRDFNIPG 117
Query: 352 FPTLKYF----KNGEKYAVPVL-----RTKKKFLEWMQN-----PEAPPPPEPTWEEQ 395
FPT+++F KNG PV +++ ++ +++ P A PP EP E+
Sbjct: 118 FPTVRFFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHHDTWPPACPPLEPAKLEE 175
Score = 46.2 bits (108), Expect = 7e-05
Identities = 21/62 (33%), Positives = 34/62 (54%), Gaps = 1/62 (1%)
Query: 419 VMFYAPWCPHCKKVIPHFTATADAFKDDRK-IACAAVDCVKDKNQDLCQQEAVKGYPTFH 477
V F+A WC HC P + A A+ K R + AA+DC ++ N +C+ + G+PT
Sbjct: 63 VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122
Query: 478 YY 479
++
Sbjct: 123 FF 124
Score = 35.4 bits (80), Expect = 0.13
Identities = 44/230 (19%), Positives = 73/230 (31%), Gaps = 63/230 (27%)
Query: 175 IMFYAPWCSMCKRMMPHFQKAATQL---RGHAVLAGMNVYSSEFENIKEEYSVRGFPTIC 231
+ F+A WC C P ++ A + R LA ++ + ++++ GFPT+
Sbjct: 63 VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTV- 121
Query: 232 YFEKGRFLFQYDNYGSTAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVK 291
RF + GS G+V+ + D +
Sbjct: 122 -----RFFKAFTKNGS----------------------------GAVFPVAGADVQTLRE 148
Query: 292 EHSSVLVMFHAPWCGHCKKMKPE--------------------FEKAAEALHGE-----A 326
L H W C ++P FEK L E +
Sbjct: 149 RLIDALESHHDTWPPACPPLEPAKLEEIDGFFARNNEEYLALIFEKGGSYLGREVALDLS 208
Query: 327 DSSGVLAAVDATVNKALAERFHISEFPT-LKYFKNGEKYAVPVLRTKKKF 375
GV + +F +++FP+ F+NG VPVL + F
Sbjct: 209 QHKGVAVRRVLNTEANVVRKFGVTDFPSCYLLFRNGSVSRVPVLMESRSF 258
>gi|13325075 quiescin Q6 sulfhydryl oxidase 1 isoform a [Homo
sapiens]
Length = 747
Score = 47.4 bits (111), Expect = 3e-05
Identities = 36/118 (30%), Positives = 56/118 (47%), Gaps = 17/118 (14%)
Query: 294 SSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDAT--VNKALAERFHISE 351
S+ V F A WCGHC P ++ AE + + LAA+D N A+ F+I
Sbjct: 59 SAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPAL-YLAALDCAEETNSAVCRDFNIPG 117
Query: 352 FPTLKYF----KNGEKYAVPVL-----RTKKKFLEWMQN-----PEAPPPPEPTWEEQ 395
FPT+++F KNG PV +++ ++ +++ P A PP EP E+
Sbjct: 118 FPTVRFFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHHDTWPPACPPLEPAKLEE 175
Score = 46.2 bits (108), Expect = 7e-05
Identities = 21/62 (33%), Positives = 34/62 (54%), Gaps = 1/62 (1%)
Query: 419 VMFYAPWCPHCKKVIPHFTATADAFKDDRK-IACAAVDCVKDKNQDLCQQEAVKGYPTFH 477
V F+A WC HC P + A A+ K R + AA+DC ++ N +C+ + G+PT
Sbjct: 63 VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122
Query: 478 YY 479
++
Sbjct: 123 FF 124
Score = 35.4 bits (80), Expect = 0.13
Identities = 44/230 (19%), Positives = 73/230 (31%), Gaps = 63/230 (27%)
Query: 175 IMFYAPWCSMCKRMMPHFQKAATQL---RGHAVLAGMNVYSSEFENIKEEYSVRGFPTIC 231
+ F+A WC C P ++ A + R LA ++ + ++++ GFPT+
Sbjct: 63 VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTV- 121
Query: 232 YFEKGRFLFQYDNYGSTAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVK 291
RF + GS G+V+ + D +
Sbjct: 122 -----RFFKAFTKNGS----------------------------GAVFPVAGADVQTLRE 148
Query: 292 EHSSVLVMFHAPWCGHCKKMKPE--------------------FEKAAEALHGE-----A 326
L H W C ++P FEK L E +
Sbjct: 149 RLIDALESHHDTWPPACPPLEPAKLEEIDGFFARNNEEYLALIFEKGGSYLGREVALDLS 208
Query: 327 DSSGVLAAVDATVNKALAERFHISEFPT-LKYFKNGEKYAVPVLRTKKKF 375
GV + +F +++FP+ F+NG VPVL + F
Sbjct: 209 QHKGVAVRRVLNTEANVVRKFGVTDFPSCYLLFRNGSVSRVPVLMESRSF 258
>gi|28372543 protein disulfide isomerase-like, testis expressed
[Homo sapiens]
Length = 584
Score = 46.6 bits (109), Expect = 6e-05
Identities = 37/130 (28%), Positives = 57/130 (43%), Gaps = 10/130 (7%)
Query: 396 QTSVLHLVGDNFRETL-KKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKIACAAV 454
Q V LVG NF + K+K VMFYAPW CK + P +++ I A +
Sbjct: 386 QGLVKQLVGKNFNVVVFDKEKDVFVMFYAPWSKKCKMLFPLLEELGRKYQNHSTIIIAKI 445
Query: 455 DCVKDKNQDLCQQEAVKGYPTFHYYHYG-KFAEKYDSDRTELGFTNY----IRALREGDH 509
D + Q + YP F + G + A Y + T GF+++ I+ E +
Sbjct: 446 DVTAND----IQLMYLDRYPFFRLFPSGSQQAVLYKGEHTLKGFSDFLESHIKTKIEDED 501
Query: 510 ERLGKKKEEL 519
E L ++ E+
Sbjct: 502 ELLSVEQNEV 511
Score = 43.9 bits (102), Expect = 4e-04
Identities = 41/197 (20%), Positives = 91/197 (46%), Gaps = 10/197 (5%)
Query: 29 LIERISDPKDLKKLLRTRNNVLVLYSKSEVAAENHLRLLSTVAQAVKGQGTICWVDCGDA 88
+IE ++ KDL L +++L+ SKS + ++ ++ + + VD +
Sbjct: 258 VIEYNTENKDLISELHIMSHMLLFVSKSSESYGIIIQHYKLASKEFQNKILFILVDADEP 317
Query: 89 ESRKLCKKMKVDLSPKDKKVELFHYQDGAFHTEYNRAVTFKSIVAF-----LKDPKGPPL 143
+ ++ K +V V++ + A + + +T++S+ F K+
Sbjct: 318 RNGRVFKYFRVT-EVDIPSVQILNLSSDARYKMPSDDITYESLKKFGRSFLSKNATKHQS 376
Query: 144 WEEDPGAKD--VVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRG 201
EE P D +V K+F ++ +EK + +MFYAPW CK + P ++ + +
Sbjct: 377 SEEIPKYWDQGLVKQLVGKNFNVVVFDKEKDVFVMFYAPWSKKCKMLFPLLEELGRKYQN 436
Query: 202 HA--VLAGMNVYSSEFE 216
H+ ++A ++V +++ +
Sbjct: 437 HSTIIIAKIDVTANDIQ 453
Score = 43.5 bits (101), Expect = 5e-04
Identities = 28/100 (28%), Positives = 47/100 (47%), Gaps = 5/100 (5%)
Query: 268 ETPWADEGGSVYHLTDEDFDQFV-KEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEA 326
E P + G V L ++F+ V + V VMF+APW CK + P E+
Sbjct: 379 EIPKYWDQGLVKQLVGKNFNVVVFDKEKDVFVMFYAPWSKKCKMLFPLLEELGRKYQNH- 437
Query: 327 DSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGEKYAV 366
S+ ++A +D T N + ++ +P + F +G + AV
Sbjct: 438 -STIIIAKIDVTAND--IQLMYLDRYPFFRLFPSGSQQAV 474
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/90 (28%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 274 EGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLA 333
E S+ LT Q + + ++V+FH P + + E KA E + G+ +
Sbjct: 41 EERSLLVLTPAGLTQMLNQTRFLMVLFHNPSSKQSRNLAEELGKAVEIM-GKGKNGIGFG 99
Query: 334 AVDATVNKALAERFHISEFPTLKYFKNGEK 363
VD T+ K L + F I++ P LK F G +
Sbjct: 100 KVDITIEKELQQEFGITKAPELKLFFEGNR 129
>gi|50592994 thioredoxin [Homo sapiens]
Length = 105
Score = 43.5 bits (101), Expect = 5e-04
Identities = 23/68 (33%), Positives = 34/68 (50%), Gaps = 5/68 (7%)
Query: 296 VLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAERFHISEFPTL 355
V+V F A WCG CK +KP F +E S+ + VD + +A + PT
Sbjct: 23 VVVDFSATWCGPCKMIKPFFHSLSEKY-----SNVIFLEVDVDDCQDVASECEVKCMPTF 77
Query: 356 KYFKNGEK 363
++FK G+K
Sbjct: 78 QFFKKGQK 85
Score = 37.4 bits (85), Expect = 0.033
Identities = 21/86 (24%), Positives = 44/86 (51%), Gaps = 4/86 (4%)
Query: 153 VVHLDSEKDFRRLLKKE-EKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVY 211
V ++S+ F+ L +K +++ F A WC CK + P F + + ++ + + V
Sbjct: 2 VKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEK---YSNVIFLEVD 58
Query: 212 SSEFENIKEEYSVRGFPTICYFEKGR 237
+ +++ E V+ PT +F+KG+
Sbjct: 59 VDDCQDVASECEVKCMPTFQFFKKGQ 84
Score = 37.4 bits (85), Expect = 0.033
Identities = 24/90 (26%), Positives = 40/90 (44%), Gaps = 7/90 (7%)
Query: 407 FRETLKKKKHTLVM--FYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDL 464
F+E L LV+ F A WC CK + P F + ++ + + + DC QD+
Sbjct: 11 FQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDC-----QDV 65
Query: 465 CQQEAVKGYPTFHYYHYGKFAEKYDSDRTE 494
+ VK PTF ++ G+ ++ E
Sbjct: 66 ASECEVKCMPTFQFFKKGQKVGEFSGANKE 95
>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 42.4 bits (98), Expect = 0.001
Identities = 32/104 (30%), Positives = 48/104 (46%), Gaps = 9/104 (8%)
Query: 262 PQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVM--FHAPWCGHCKKMKPEFEKAA 319
P+ + E P D+ + L+ EDF+ +KE LV F A WCG C+ ++P F A
Sbjct: 370 PEEETMEFPEGDKVKVI--LSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFH-AL 426
Query: 320 EALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGEK 363
H + V VDA + + I PT +++K EK
Sbjct: 427 SVKHEDV----VFLEVDADNCEEVVRECAIMCVPTFQFYKKEEK 466
Score = 37.0 bits (84), Expect = 0.044
Identities = 23/91 (25%), Positives = 43/91 (47%), Gaps = 4/91 (4%)
Query: 146 EDPGAKDVVHLDSEKDFRRLLKKE-EKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGHAV 204
E P V + S++DF LK+ E+ + + F A WC C+ + P F + + H
Sbjct: 376 EFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALSVK---HED 432
Query: 205 LAGMNVYSSEFENIKEEYSVRGFPTICYFEK 235
+ + V + E + E ++ PT +++K
Sbjct: 433 VVFLEVDADNCEEVVRECAIMCVPTFQFYKK 463
Score = 35.4 bits (80), Expect = 0.13
Identities = 30/107 (28%), Positives = 50/107 (46%), Gaps = 12/107 (11%)
Query: 387 PPEPTWEEQQTSVLHLV--GDNFRETLKKKKHTLVM--FYAPWCPHCKKVIPHFTATADA 442
P E T E + + ++ ++F +LK+ LV F A WC C+ + P F A +
Sbjct: 370 PEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALSVK 429
Query: 443 FKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYD 489
+D + VD D +++ ++ A+ PTF +Y K EK D
Sbjct: 430 HED---VVFLEVDA--DNCEEVVRECAIMCVPTFQFY---KKEEKVD 468
>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
sapiens]
Length = 553
Score = 42.4 bits (98), Expect = 0.001
Identities = 32/104 (30%), Positives = 48/104 (46%), Gaps = 9/104 (8%)
Query: 262 PQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVM--FHAPWCGHCKKMKPEFEKAA 319
P+ + E P D+ + L+ EDF+ +KE LV F A WCG C+ ++P F A
Sbjct: 437 PEEETMEFPEGDKVKVI--LSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFH-AL 493
Query: 320 EALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGEK 363
H + V VDA + + I PT +++K EK
Sbjct: 494 SVKHEDV----VFLEVDADNCEEVVRECAIMCVPTFQFYKKEEK 533
Score = 37.0 bits (84), Expect = 0.044
Identities = 23/91 (25%), Positives = 43/91 (47%), Gaps = 4/91 (4%)
Query: 146 EDPGAKDVVHLDSEKDFRRLLKKE-EKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGHAV 204
E P V + S++DF LK+ E+ + + F A WC C+ + P F + + H
Sbjct: 443 EFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALSVK---HED 499
Query: 205 LAGMNVYSSEFENIKEEYSVRGFPTICYFEK 235
+ + V + E + E ++ PT +++K
Sbjct: 500 VVFLEVDADNCEEVVRECAIMCVPTFQFYKK 530
Score = 35.4 bits (80), Expect = 0.13
Identities = 30/107 (28%), Positives = 50/107 (46%), Gaps = 12/107 (11%)
Query: 387 PPEPTWEEQQTSVLHLV--GDNFRETLKKKKHTLVM--FYAPWCPHCKKVIPHFTATADA 442
P E T E + + ++ ++F +LK+ LV F A WC C+ + P F A +
Sbjct: 437 PEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALSVK 496
Query: 443 FKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYD 489
+D + VD D +++ ++ A+ PTF +Y K EK D
Sbjct: 497 HED---VVFLEVDA--DNCEEVVRECAIMCVPTFQFY---KKEEKVD 535
>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 42.4 bits (98), Expect = 0.001
Identities = 32/104 (30%), Positives = 48/104 (46%), Gaps = 9/104 (8%)
Query: 262 PQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVM--FHAPWCGHCKKMKPEFEKAA 319
P+ + E P D+ + L+ EDF+ +KE LV F A WCG C+ ++P F A
Sbjct: 370 PEEETMEFPEGDKVKVI--LSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFH-AL 426
Query: 320 EALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGEK 363
H + V VDA + + I PT +++K EK
Sbjct: 427 SVKHEDV----VFLEVDADNCEEVVRECAIMCVPTFQFYKKEEK 466
Score = 37.0 bits (84), Expect = 0.044
Identities = 23/91 (25%), Positives = 43/91 (47%), Gaps = 4/91 (4%)
Query: 146 EDPGAKDVVHLDSEKDFRRLLKKE-EKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGHAV 204
E P V + S++DF LK+ E+ + + F A WC C+ + P F + + H
Sbjct: 376 EFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALSVK---HED 432
Query: 205 LAGMNVYSSEFENIKEEYSVRGFPTICYFEK 235
+ + V + E + E ++ PT +++K
Sbjct: 433 VVFLEVDADNCEEVVRECAIMCVPTFQFYKK 463
Score = 35.4 bits (80), Expect = 0.13
Identities = 30/107 (28%), Positives = 50/107 (46%), Gaps = 12/107 (11%)
Query: 387 PPEPTWEEQQTSVLHLV--GDNFRETLKKKKHTLVM--FYAPWCPHCKKVIPHFTATADA 442
P E T E + + ++ ++F +LK+ LV F A WC C+ + P F A +
Sbjct: 370 PEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALSVK 429
Query: 443 FKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYD 489
+D + VD D +++ ++ A+ PTF +Y K EK D
Sbjct: 430 HED---VVFLEVDA--DNCEEVVRECAIMCVPTFQFY---KKEEKVD 468
>gi|54633317 thioredoxin domain containing 11 [Homo sapiens]
Length = 958
Score = 40.4 bits (93), Expect = 0.004
Identities = 23/86 (26%), Positives = 42/86 (48%), Gaps = 4/86 (4%)
Query: 278 VYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDA 337
+ +T + F + V + VL++++APWCG C + F + A L + + +A +D
Sbjct: 665 ITEVTTDTFWEVVLQKQDVLLLYYAPWCGFCPSLNHIFIQLARNLPMD---TFTVARIDV 721
Query: 338 TVNKALAERFHISEFPTLKYFKNGEK 363
+ N L F + PT+ +F K
Sbjct: 722 SQND-LPWEFMVDRLPTVLFFPCNRK 746
Score = 37.0 bits (84), Expect = 0.044
Identities = 16/75 (21%), Positives = 39/75 (52%), Gaps = 1/75 (1%)
Query: 161 DFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKE 220
D+ ++++ + +L+ FYAPWC ++AA++L + +N + ++ + K+
Sbjct: 116 DYAEYVRRDSEVVLLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQ 175
Query: 221 EYSVRGFPTICYFEK 235
++ FP I + +
Sbjct: 176 KHFFY-FPVIYLYHR 189
Score = 35.4 bits (80), Expect = 0.13
Identities = 16/39 (41%), Positives = 24/39 (61%), Gaps = 1/39 (2%)
Query: 285 DFDQFVKEHSSV-LVMFHAPWCGHCKKMKPEFEKAAEAL 322
D+ ++V+ S V L+ F+APWCG + E E+AA L
Sbjct: 116 DYAEYVRRDSEVVLLFFYAPWCGQSIAARAEIEQAASRL 154
Score = 33.5 bits (75), Expect = 0.48
Identities = 12/34 (35%), Positives = 20/34 (58%)
Query: 396 QTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHC 429
Q + + D F E + +K+ L+++YAPWC C
Sbjct: 662 QHLITEVTTDTFWEVVLQKQDVLLLYYAPWCGFC 695
Score = 32.3 bits (72), Expect = 1.1
Identities = 18/70 (25%), Positives = 36/70 (51%), Gaps = 4/70 (5%)
Query: 169 EEKPLLIMFYAPWCSMCKRMMPHFQKAATQL-RGHAVLAGMNVYSSEFENIKEEYSVRGF 227
+++ +L+++YAPWC C + F + A L +A ++V ++ + E+ V
Sbjct: 679 QKQDVLLLYYAPWCGFCPSLNHIFIQLARNLPMDTFTVARIDVSQND---LPWEFMVDRL 735
Query: 228 PTICYFEKGR 237
PT+ +F R
Sbjct: 736 PTVLFFPCNR 745
>gi|95113651 glutaredoxin 3 [Homo sapiens]
Length = 335
Score = 39.3 bits (90), Expect = 0.009
Identities = 41/167 (24%), Positives = 75/167 (44%), Gaps = 22/167 (13%)
Query: 153 VVHLDSEKDFRRLLKKEEKPLLIM-FYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVY 211
V + S F LL+ + K LL++ F+APW C +M + A +L ++ + +
Sbjct: 13 VEEVGSAGQFEELLRLKAKSLLVVHFWAPWAPQCAQMNEVMAELAKEL---PQVSFVKLE 69
Query: 212 SSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTAEDIVEWLKNPQPPQPQVPETPW 271
+ + E+Y + PT +F+ + + + D G+ A ++ K Q P
Sbjct: 70 AEGVPEVSEKYEISSVPTFLFFKNSQKIDRLD--GAHAPELT---KKVQRHASSGSFLPS 124
Query: 272 ADEGGSVYHLTDEDFDQFVKE--HSSVLVMF-----HAPWCGHCKKM 311
A+E HL ED + +K+ H++ ++F P CG K+M
Sbjct: 125 ANE-----HL-KEDLNLRLKKLTHAAPCMLFMKGTPQEPRCGFSKQM 165
Score = 37.0 bits (84), Expect = 0.044
Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 5/74 (6%)
Query: 290 VKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAERFHI 349
+K S ++V F APW C +M + A+ L + ++A ++E++ I
Sbjct: 28 LKAKSLLVVHFWAPWAPQCAQMNEVMAELAKELPQVS-----FVKLEAEGVPEVSEKYEI 82
Query: 350 SEFPTLKYFKNGEK 363
S PT +FKN +K
Sbjct: 83 SSVPTFLFFKNSQK 96
>gi|51510891 thioredoxin domain containing 8 [Homo sapiens]
Length = 115
Score = 39.3 bits (90), Expect = 0.009
Identities = 23/71 (32%), Positives = 30/71 (42%), Gaps = 5/71 (7%)
Query: 293 HSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAERFHISEF 352
H +V F + CG CK+M P F + A VD + LAE HI
Sbjct: 20 HKLAVVQFSSKRCGPCKRMFPVFHAMSVKYQNV-----FFANVDVNNSPELAETCHIKTI 74
Query: 353 PTLKYFKNGEK 363
PT + FK +K
Sbjct: 75 PTFQMFKKSQK 85
>gi|94421469 disulfide isomerase [Homo sapiens]
Length = 360
Score = 37.0 bits (84), Expect = 0.044
Identities = 18/85 (21%), Positives = 38/85 (44%), Gaps = 3/85 (3%)
Query: 174 LIMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYF 233
L++FY PWC + PHF R L + + +S+ ++ + P I F
Sbjct: 212 LVLFYTPWCRFSASLAPHFNSLP---RAFPALHFLALDASQHSSLSTRFGTVAVPNILLF 268
Query: 234 EKGRFLFQYDNYGSTAEDIVEWLKN 258
+ + + ++++ T E + ++ N
Sbjct: 269 QGAKPMARFNHTDRTLETLKIFIFN 293
Score = 36.2 bits (82), Expect = 0.074
Identities = 24/87 (27%), Positives = 39/87 (44%), Gaps = 13/87 (14%)
Query: 284 EDFDQFVKEHSS--VLVMFHAPWCGHCKKMKPEFE---KAAEALHGEADSSGVLAAVDAT 338
+D F+ + S LV+F+ PWC + P F +A ALH A+DA+
Sbjct: 197 QDLMDFLNPNGSDCTLVLFYTPWCRFSASLAPHFNSLPRAFPALH--------FLALDAS 248
Query: 339 VNKALAERFHISEFPTLKYFKNGEKYA 365
+ +L+ RF P + F+ + A
Sbjct: 249 QHSSLSTRFGTVAVPNILLFQGAKPMA 275
Score = 34.7 bits (78), Expect = 0.22
Identities = 13/27 (48%), Positives = 16/27 (59%)
Query: 417 TLVMFYAPWCPHCKKVIPHFTATADAF 443
TLV+FY PWC + PHF + AF
Sbjct: 211 TLVLFYTPWCRFSASLAPHFNSLPRAF 237
>gi|40254947 thioredoxin-related transmembrane protein 4 [Homo
sapiens]
Length = 349
Score = 35.8 bits (81), Expect = 0.097
Identities = 21/65 (32%), Positives = 33/65 (50%), Gaps = 3/65 (4%)
Query: 297 LVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAERFHISEFPTLK 356
++ F+APWC C++ E+E A A +GE V VD L+ RF ++ P
Sbjct: 56 MLKFYAPWCPSCQQTDSEWE--AFAKNGEILQISV-GKVDVIQEPGLSGRFFVTTLPAFF 112
Query: 357 YFKNG 361
+ K+G
Sbjct: 113 HAKDG 117
Score = 34.3 bits (77), Expect = 0.28
Identities = 17/54 (31%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 387 PPEPTWEEQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHFTATA 440
P E +Q+ V + N+ TL + ++ FYAPWCP C++ + A A
Sbjct: 27 PEEAALPPEQSRVQPMTASNW--TLVMEGEWMLKFYAPWCPSCQQTDSEWEAFA 78
>gi|237648961 thioredoxin domain containing 16 isoform 2 [Homo
sapiens]
Length = 820
Score = 35.4 bits (80), Expect = 0.13
Identities = 33/154 (21%), Positives = 68/154 (44%), Gaps = 14/154 (9%)
Query: 174 LIMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYF 233
+++FYA W ++ + + A +L+G + + + +++ ++ + +V FP I +
Sbjct: 406 IVLFYAGWQAVSMAFLQSYIDVAVKLKGTSTMLLTRINCADWSDVCTKQNVTEFPIIKMY 465
Query: 234 EKGRFLFQYDNYGSTAEDIVEWLKNPQPPQP-QVPETPWADE--GGSVYHLTDEDFDQFV 290
+KG Y T ED++++++ + P + A+E G +Y D +
Sbjct: 466 KKGENPVSYAGMLGT-EDLLKFIQLNRISYPVNITSIQEAEEYLSGELYK------DLIL 518
Query: 291 KEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHG 324
SVL +F K K +F +A L G
Sbjct: 519 YSSVSVLGLFSPT----MKTAKEDFSEAGNYLKG 548
Score = 32.3 bits (72), Expect = 1.1
Identities = 22/82 (26%), Positives = 39/82 (47%), Gaps = 3/82 (3%)
Query: 281 LTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVN 340
LT+E F+ V S+ V+F+A W + A L G S+ +L ++
Sbjct: 391 LTEETFNATVMASDSI-VLFYAGWQAVSMAFLQSYIDVAVKLKGT--STMLLTRINCADW 447
Query: 341 KALAERFHISEFPTLKYFKNGE 362
+ + +++EFP +K +K GE
Sbjct: 448 SDVCTKQNVTEFPIIKMYKKGE 469
>gi|237648959 thioredoxin domain containing 16 isoform 1 [Homo
sapiens]
Length = 825
Score = 35.4 bits (80), Expect = 0.13
Identities = 33/154 (21%), Positives = 68/154 (44%), Gaps = 14/154 (9%)
Query: 174 LIMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYF 233
+++FYA W ++ + + A +L+G + + + +++ ++ + +V FP I +
Sbjct: 411 IVLFYAGWQAVSMAFLQSYIDVAVKLKGTSTMLLTRINCADWSDVCTKQNVTEFPIIKMY 470
Query: 234 EKGRFLFQYDNYGSTAEDIVEWLKNPQPPQP-QVPETPWADE--GGSVYHLTDEDFDQFV 290
+KG Y T ED++++++ + P + A+E G +Y D +
Sbjct: 471 KKGENPVSYAGMLGT-EDLLKFIQLNRISYPVNITSIQEAEEYLSGELYK------DLIL 523
Query: 291 KEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHG 324
SVL +F K K +F +A L G
Sbjct: 524 YSSVSVLGLFSPT----MKTAKEDFSEAGNYLKG 553
Score = 32.3 bits (72), Expect = 1.1
Identities = 22/82 (26%), Positives = 39/82 (47%), Gaps = 3/82 (3%)
Query: 281 LTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVN 340
LT+E F+ V S+ V+F+A W + A L G S+ +L ++
Sbjct: 396 LTEETFNATVMASDSI-VLFYAGWQAVSMAFLQSYIDVAVKLKGT--STMLLTRINCADW 452
Query: 341 KALAERFHISEFPTLKYFKNGE 362
+ + +++EFP +K +K GE
Sbjct: 453 SDVCTKQNVTEFPIIKMYKKGE 474
>gi|7705696 thioredoxin domain containing 12 [Homo sapiens]
Length = 172
Score = 34.7 bits (78), Expect = 0.22
Identities = 11/25 (44%), Positives = 18/25 (72%)
Query: 296 VLVMFHAPWCGHCKKMKPEFEKAAE 320
++V+ H WCG CK +KP+F ++ E
Sbjct: 57 LMVIIHKSWCGACKALKPKFAESTE 81
Score = 34.3 bits (77), Expect = 0.28
Identities = 29/128 (22%), Positives = 56/128 (43%), Gaps = 21/128 (16%)
Query: 149 GAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAA--TQLRGHAVLA 206
G D +H + +D ++ PL+++ + WC CK + P F ++ ++L + V+
Sbjct: 33 GFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMV 92
Query: 207 GMNVYSSEFENIKEEYSVRG--FPTICYF------------EKGRFLFQYDNYGSTAEDI 252
+ E E E++S G P I + E G ++Y + +AE +
Sbjct: 93 NL---EDEEEPKDEDFSPDGGYIPRILFLDPSGKVHPEIINENGNPSYKY--FYVSAEQV 147
Query: 253 VEWLKNPQ 260
V+ +K Q
Sbjct: 148 VQGMKEAQ 155
>gi|18104959 thioredoxin domain containing 9 [Homo sapiens]
Length = 226
Score = 31.2 bits (69), Expect = 2.4
Identities = 34/120 (28%), Positives = 50/120 (41%), Gaps = 14/120 (11%)
Query: 250 EDIVEWLKNPQPP---QPQVPETPWADEGGSVYHL--TDEDFDQFVKEHSSVLVMFHAPW 304
ED +E LK + + Q + W +G Y ++ DF Q VKE +V+ F+
Sbjct: 41 EDELERLKEKRLQALRKAQQQKQEWLSKGHGEYREIPSERDFFQEVKESENVVCHFYRDS 100
Query: 305 CGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKA--LAERFHISEFPTLKYFKNGE 362
CK + ++ H E + V KA L ER HI PTL K+G+
Sbjct: 101 TFRCKILDRHLAILSKK-HLETKF------LKLNVEKAPFLCERLHIKVIPTLALLKDGK 153
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,400,345
Number of Sequences: 37866
Number of extensions: 1061878
Number of successful extensions: 4218
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 4010
Number of HSP's gapped (non-prelim): 133
length of query: 519
length of database: 18,247,518
effective HSP length: 107
effective length of query: 412
effective length of database: 14,195,856
effective search space: 5848692672
effective search space used: 5848692672
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.