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Search of human proteins with 56788370
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo
sapiens]
(1056 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens] 2207 0.0
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens] 473 e-133
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ... 459 e-129
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6... 459 e-129
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens] 432 e-121
gi|4758968 cytohesin 3 [Homo sapiens] 112 1e-24
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens] 111 4e-24
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens] 111 4e-24
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 111 4e-24
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] 111 4e-24
gi|7019505 cytohesin 4 [Homo sapiens] 100 7e-21
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr... 96 1e-19
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens] 93 1e-18
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens] 93 1e-18
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange... 89 3e-17
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens] 89 3e-17
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti... 87 6e-17
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens] 83 1e-15
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens] 83 1e-15
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 69 2e-11
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 61 6e-09
gi|67782321 spectrin beta isoform a [Homo sapiens] 59 2e-08
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 54 6e-07
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 54 1e-06
gi|208022661 hypothetical protein LOC57701 [Homo sapiens] 54 1e-06
gi|48928044 F-box only protein 8 [Homo sapiens] 53 2e-06
gi|41281612 zinc finger protein 828 [Homo sapiens] 52 4e-06
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 50 1e-05
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo... 49 2e-05
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ... 49 2e-05
>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
Length = 1056
Score = 2207 bits (5719), Expect = 0.0
Identities = 1056/1056 (100%), Positives = 1056/1056 (100%)
Query: 1 MMGDYRLPDHPQPMEILNLYLGDSLEPHPGECPRETCSHEDPPEPFEEQTWATDPPEPTR 60
MMGDYRLPDHPQPMEILNLYLGDSLEPHPGECPRETCSHEDPPEPFEEQTWATDPPEPTR
Sbjct: 1 MMGDYRLPDHPQPMEILNLYLGDSLEPHPGECPRETCSHEDPPEPFEEQTWATDPPEPTR 60
Query: 61 QNVPPWGSGVELTHLGSWVHQDGLEPCQEQTRATDPPESTRQDAPPWGSGVELTHLGSPS 120
QNVPPWGSGVELTHLGSWVHQDGLEPCQEQTRATDPPESTRQDAPPWGSGVELTHLGSPS
Sbjct: 61 QNVPPWGSGVELTHLGSWVHQDGLEPCQEQTRATDPPESTRQDAPPWGSGVELTHLGSPS 120
Query: 121 AQREHRQNTASPGSPVNSHLPGSPKQNRSTSTQVVFWAGILQAQMCVLDLEEELEKTEGL 180
AQREHRQNTASPGSPVNSHLPGSPKQNRSTSTQVVFWAGILQAQMCVLDLEEELEKTEGL
Sbjct: 121 AQREHRQNTASPGSPVNSHLPGSPKQNRSTSTQVVFWAGILQAQMCVLDLEEELEKTEGL 180
Query: 181 KAGLKCCLPTPPVDLPGDTGLHSSPPENEDSGEDSSEPEGEGQAWLREGTPDSSPQWGAE 240
KAGLKCCLPTPPVDLPGDTGLHSSPPENEDSGEDSSEPEGEGQAWLREGTPDSSPQWGAE
Sbjct: 181 KAGLKCCLPTPPVDLPGDTGLHSSPPENEDSGEDSSEPEGEGQAWLREGTPDSSPQWGAE 240
Query: 241 EESMFFSNPLFLASPCSENSASGECFSWGASDSHAGVRTGPESPATLEPPLPEDTVLWEL 300
EESMFFSNPLFLASPCSENSASGECFSWGASDSHAGVRTGPESPATLEPPLPEDTVLWEL
Sbjct: 241 EESMFFSNPLFLASPCSENSASGECFSWGASDSHAGVRTGPESPATLEPPLPEDTVLWEL 300
Query: 301 ESEPDLGDGAAISGHCTPPFPVPIYKPHSICWASVAAAEGAPAAPPGHGESEGDRLGPAP 360
ESEPDLGDGAAISGHCTPPFPVPIYKPHSICWASVAAAEGAPAAPPGHGESEGDRLGPAP
Sbjct: 301 ESEPDLGDGAAISGHCTPPFPVPIYKPHSICWASVAAAEGAPAAPPGHGESEGDRLGPAP 360
Query: 361 SAAPCVDEALTWESGCVGSDLGPAAHPVQPWASLSPEGWQRGGPFWPQVTLNSQDRDERE 420
SAAPCVDEALTWESGCVGSDLGPAAHPVQPWASLSPEGWQRGGPFWPQVTLNSQDRDERE
Sbjct: 361 SAAPCVDEALTWESGCVGSDLGPAAHPVQPWASLSPEGWQRGGPFWPQVTLNSQDRDERE 420
Query: 421 GGHPQESLPCTLAPCPWRSPASSPEPSSPESESRGPGPRPSPASSQEGSPQLQHHSSGIL 480
GGHPQESLPCTLAPCPWRSPASSPEPSSPESESRGPGPRPSPASSQEGSPQLQHHSSGIL
Sbjct: 421 GGHPQESLPCTLAPCPWRSPASSPEPSSPESESRGPGPRPSPASSQEGSPQLQHHSSGIL 480
Query: 481 PKWTLDASQSSLLETDGEQPSSLKKKEAGEAPKPGEEVKSEGTARPAETGDVQPDIHLTS 540
PKWTLDASQSSLLETDGEQPSSLKKKEAGEAPKPGEEVKSEGTARPAETGDVQPDIHLTS
Sbjct: 481 PKWTLDASQSSLLETDGEQPSSLKKKEAGEAPKPGEEVKSEGTARPAETGDVQPDIHLTS 540
Query: 541 AEHENLRTPMNSSWLPGSPMPQAQSPEEGQRPPAGDKLANGVRNNKVAWNLASRLYRLEG 600
AEHENLRTPMNSSWLPGSPMPQAQSPEEGQRPPAGDKLANGVRNNKVAWNLASRLYRLEG
Sbjct: 541 AEHENLRTPMNSSWLPGSPMPQAQSPEEGQRPPAGDKLANGVRNNKVAWNLASRLYRLEG 600
Query: 601 FRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLSGETQERERILY 660
FRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLSGETQERERILY
Sbjct: 601 FRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLSGETQERERILY 660
Query: 661 QFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFITNLNGLRDGGN 720
QFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFITNLNGLRDGGN
Sbjct: 661 QFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFITNLNGLRDGGN 720
Query: 721 FPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFLQLAQDPTVPTYKQ 780
FPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFLQLAQDPTVPTYKQ
Sbjct: 721 FPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFLQLAQDPTVPTYKQ 780
Query: 781 GILARKMHQDADGKKTPWGKRGWKMFHTLLRGMVLYFLKQGEDHCLEGESLVGQMVDEPV 840
GILARKMHQDADGKKTPWGKRGWKMFHTLLRGMVLYFLKQGEDHCLEGESLVGQMVDEPV
Sbjct: 781 GILARKMHQDADGKKTPWGKRGWKMFHTLLRGMVLYFLKQGEDHCLEGESLVGQMVDEPV 840
Query: 841 GVHHSLATPATHYTKKPHVFQLRTADWRLYLFQAPTAKEMSSWIARINLAAATHSAPPFP 900
GVHHSLATPATHYTKKPHVFQLRTADWRLYLFQAPTAKEMSSWIARINLAAATHSAPPFP
Sbjct: 841 GVHHSLATPATHYTKKPHVFQLRTADWRLYLFQAPTAKEMSSWIARINLAAATHSAPPFP 900
Query: 901 AAVGSQRRFVRPILPVGPAQSSLEEQHRSHENCLDAAADDLLDLQRNLPERRGRGRELEE 960
AAVGSQRRFVRPILPVGPAQSSLEEQHRSHENCLDAAADDLLDLQRNLPERRGRGRELEE
Sbjct: 901 AAVGSQRRFVRPILPVGPAQSSLEEQHRSHENCLDAAADDLLDLQRNLPERRGRGRELEE 960
Query: 961 HRLRKEYLEYEKTRYETYVQLLVARLHCPSDALDLWEEQLGREAGGTREPKLSLKKSHSS 1020
HRLRKEYLEYEKTRYETYVQLLVARLHCPSDALDLWEEQLGREAGGTREPKLSLKKSHSS
Sbjct: 961 HRLRKEYLEYEKTRYETYVQLLVARLHCPSDALDLWEEQLGREAGGTREPKLSLKKSHSS 1020
Query: 1021 PSLHQDEAPTTAKVKRNISERRTYRKIIPKRNRNQL 1056
PSLHQDEAPTTAKVKRNISERRTYRKIIPKRNRNQL
Sbjct: 1021 PSLHQDEAPTTAKVKRNISERRTYRKIIPKRNRNQL 1056
>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
Length = 1024
Score = 473 bits (1217), Expect = e-133
Identities = 340/895 (37%), Positives = 450/895 (50%), Gaps = 94/895 (10%)
Query: 195 LPGDTGLHSSPPENEDSGED---SSEPEGEGQAWLREGTPDSSP-QWGAEEESMFFSNPL 250
LPG L PP G D SS P G G R T P G + +S+P
Sbjct: 167 LPGSRNLVHGPPAPPQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPR 226
Query: 251 FLASPCSENSASGECFSWGASDSHAGVRTGPESPATLEPPLPEDTVLWELESEPDLGDGA 310
++S + + F +G+ D + PE PP P V S +G A
Sbjct: 227 EVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQA----PPSPPG-VGSRQGSGVAVGRAA 281
Query: 311 AISGHCTPPFPVPIYKPHSI--CWASVAAAEGAPAAPPGHGESEGDRLGPAPSAAPCVDE 368
S P+ Y+ I A A+ A + P G PAP P
Sbjct: 282 KYSETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPL--- 338
Query: 369 ALTWESGCVGSDLGPAAHPVQPWASLSPEGWQRGGPFWPQVTLNSQDRDEREGGHPQESL 428
P HP + + + GG + ++ + + EG P +
Sbjct: 339 --------------PGPHPSLGSGNEDEDDDEAGG----EEDVDDEVFEASEGARPGSRM 380
Query: 429 PCTLAPCPWRSPASSPEPSSPESES--------------------------RGPGPRPSP 462
P +P P+ P +SP P+S S PGP SP
Sbjct: 381 PLK-SPVPFL-PGTSPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQSP 438
Query: 463 ASSQEGSPQLQHHSSGILPKWTLDASQSSLLETDGEQPSSLKKKEAGEAPKPGEEVKSEG 522
+ E PQ P A + L E S G + GEE ++E
Sbjct: 439 FFTFELPPQ----PPAPRPDPPAPAPLAPL-----EPDSGTSSAADGPWTQRGEEEEAEA 489
Query: 523 TARPAETGDVQPDIHLTSAEHENLRTPMNSSWLPGSPMPQAQSPE--EGQRPPAG--DKL 578
A+ A + H S + L S P S + E +R G D L
Sbjct: 490 RAKLAPGREPPSPCH--SEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTL 547
Query: 579 ANGVRNN-KVAWNLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDR 637
+NG + + + A LA RLYRL+GFRK++VA +L KNNDFS+ VA EYL FF F G +LD+
Sbjct: 548 SNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQ 607
Query: 638 ALRSFLQALVLSGETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQ 697
ALR FL+ L L GETQERER+L FS+R+ CNP S D HTLTCA+MLLNTDLHG
Sbjct: 608 ALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGH 667
Query: 698 NIGKSMSCQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTAR--PEKAQP 755
NIGK M+C +FI NL GL DGG+FP+ELLKALY SI++EKL+WA+DEE+ R E A P
Sbjct: 668 NIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADP 727
Query: 756 --------SLPAGKMSKPFLQLAQDPTVPTYKQGILARKMHQDADGKKTPWGKRGWKMFH 807
S +G S PFL L +P YK G L RK+H D D +KTP GKRGWK FH
Sbjct: 728 NPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGKRGWKSFH 787
Query: 808 TLLRGMVLYFLKQGEDHCLEGESLVGQMVDEPVGVHHSLATPATHYTKKPHVFQLRTADW 867
+L+GM+LY K + G++L + + +HH+LAT A+ Y+K+PHVF LRTADW
Sbjct: 788 GILKGMILYLQK---EEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLRTADW 844
Query: 868 RLYLFQAPTAKEMSSWIARINLAAATHSAPPFPAAVGSQRRFVRPILPVGPAQSSLEEQH 927
R++LFQAP+ ++M SWI RIN+ AA SAPPFPAAV SQ++F RP+LP + S EEQ
Sbjct: 845 RVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQV 904
Query: 928 RSHENCLDAAADDLLDLQRNLPERRGRGRELEEHRLRKEYLEYEKTRYETYVQLLVARLH 987
R+HE L A A +L + + ++GRG+E EE R ++ YLE+EK+RY TY LL +L
Sbjct: 905 RTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLRVKLK 964
Query: 988 CPSDALDLWEEQLGREAGGTREPKLSLKKSHSSPSLHQDEAPTTAKVKRNISERR 1042
S+ LD E L +AG T + L SHSSPSL Q + + + +R+ SE R
Sbjct: 965 AGSEELDAVEAALA-QAGSTED---GLPPSHSSPSL-QPKPSSQPRAQRHSSEPR 1014
>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
isoform b [Homo sapiens]
Length = 513
Score = 459 bits (1181), Expect = e-129
Identities = 242/487 (49%), Positives = 324/487 (66%), Gaps = 31/487 (6%)
Query: 576 DKLANGVRNN-KVAWNLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQS 634
+ L+NG +N + A LA RLY+L+ F++S+VA +L KNN+FS+ VAEEYL FF F G +
Sbjct: 38 ENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMT 97
Query: 635 LDRALRSFLQALVLSGETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDL 694
LD++LR F +A L GETQERER+L FS R+ +CNP S D VH LTCAIMLLNTDL
Sbjct: 98 LDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDL 157
Query: 695 HGQNIGKSMSCQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTAR----- 749
HG NIGK M+CQEFI NL G+ +G +F K+LLKALY SI++EKLEWAVD+E+ +
Sbjct: 158 HGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSES 217
Query: 750 -PEKAQPSLP-----AGKMSKPFLQLAQDPTVPTYKQGILARKMHQDADGKKTPWGKRGW 803
EKA + P G + PFL + DP YK G LARK+H D DGKKTP GKRGW
Sbjct: 218 TEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGW 277
Query: 804 KMFHTLLRGMVLYFLKQGEDHCLEGESLVGQMVDEPVGVHHSLATPATHYTKKPHVFQLR 863
K F+ +L+G VLY K D ++L + + V VHH+LA+ AT Y KKP+VF+L+
Sbjct: 278 KTFYAVLKGTVLYLQK---DEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLK 334
Query: 864 TADWRLYLFQAPTAKEMSSWIARINLAAATHSAPPFPAAVGSQRRFVRPILPVGPAQSSL 923
TADWR+ LFQ + +EM WI +IN AA SAPPFPAA+GSQ++F RP+LP + S
Sbjct: 335 TADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQ 394
Query: 924 EEQHRSHENCLDAAADDLLDLQRNLPERRGRGRELEEHRLRKEYLEYEKTRYETYVQLLV 983
EEQ +SHE+ L +L + + P+++ + ++++E++L+ YLE+EKTRYE YV +L
Sbjct: 395 EEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSIL- 453
Query: 984 ARLHCPSDALDLWEEQLGREAGGTREPKLS-LKKSHSSPSLHQDEAPTTAKVKRNISERR 1042
++ G+E E + + LKKSHSSPSL+ D +P TAKVKRN+SER+
Sbjct: 454 --------------KEGGKELLSNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERK 499
Query: 1043 TYRKIIP 1049
+R P
Sbjct: 500 DHRPETP 506
>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
isoform a [Homo sapiens]
Length = 1047
Score = 459 bits (1181), Expect = e-129
Identities = 242/487 (49%), Positives = 324/487 (66%), Gaps = 31/487 (6%)
Query: 576 DKLANGVRNN-KVAWNLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQS 634
+ L+NG +N + A LA RLY+L+ F++S+VA +L KNN+FS+ VAEEYL FF F G +
Sbjct: 572 ENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMT 631
Query: 635 LDRALRSFLQALVLSGETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDL 694
LD++LR F +A L GETQERER+L FS R+ +CNP S D VH LTCAIMLLNTDL
Sbjct: 632 LDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDL 691
Query: 695 HGQNIGKSMSCQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTAR----- 749
HG NIGK M+CQEFI NL G+ +G +F K+LLKALY SI++EKLEWAVD+E+ +
Sbjct: 692 HGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSES 751
Query: 750 -PEKAQPSLP-----AGKMSKPFLQLAQDPTVPTYKQGILARKMHQDADGKKTPWGKRGW 803
EKA + P G + PFL + DP YK G LARK+H D DGKKTP GKRGW
Sbjct: 752 TEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGW 811
Query: 804 KMFHTLLRGMVLYFLKQGEDHCLEGESLVGQMVDEPVGVHHSLATPATHYTKKPHVFQLR 863
K F+ +L+G VLY K D ++L + + V VHH+LA+ AT Y KKP+VF+L+
Sbjct: 812 KTFYAVLKGTVLYLQK---DEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLK 868
Query: 864 TADWRLYLFQAPTAKEMSSWIARINLAAATHSAPPFPAAVGSQRRFVRPILPVGPAQSSL 923
TADWR+ LFQ + +EM WI +IN AA SAPPFPAA+GSQ++F RP+LP + S
Sbjct: 869 TADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQ 928
Query: 924 EEQHRSHENCLDAAADDLLDLQRNLPERRGRGRELEEHRLRKEYLEYEKTRYETYVQLLV 983
EEQ +SHE+ L +L + + P+++ + ++++E++L+ YLE+EKTRYE YV +L
Sbjct: 929 EEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSIL- 987
Query: 984 ARLHCPSDALDLWEEQLGREAGGTREPKLS-LKKSHSSPSLHQDEAPTTAKVKRNISERR 1042
++ G+E E + + LKKSHSSPSL+ D +P TAKVKRN+SER+
Sbjct: 988 --------------KEGGKELLSNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERK 1033
Query: 1043 TYRKIIP 1049
+R P
Sbjct: 1034 DHRPETP 1040
>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
Length = 771
Score = 432 bits (1112), Expect = e-121
Identities = 245/525 (46%), Positives = 324/525 (61%), Gaps = 25/525 (4%)
Query: 512 PKPGEEVKSEGTARPAETGDVQPDIHLTSAEHENLRTPMNSSWLPGSPMPQAQSPEEGQR 571
P E +G + + D L SA +L+ ++ S S EG
Sbjct: 244 PNGFHEDGPQGPGGDEDDDEEDTDKLLNSASDPSLKDGLSDS-------DSELSSSEGLE 296
Query: 572 PPAGDKLANGVRN-NKVAWNLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQF 630
P + D LANG + ++ A LA RLY LEGF++ +VA L KNN+FSR VA EYLSFF F
Sbjct: 297 PGSADPLANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDF 356
Query: 631 GGQSLDRALRSFLQALVLSGETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLL 690
G +LD ALR+FL+A L GETQERER+L FSRR+ CNP S D +HTLTCA+MLL
Sbjct: 357 SGLTLDGALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLL 416
Query: 691 NTDLHGQNIGKSMSCQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTAR- 749
NTDLHG NIGK MSCQ+FI NL+ L DG +F K+LLK LY SI++EKLEWA+DE++ +
Sbjct: 417 NTDLHGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKS 476
Query: 750 -PEKAQPSLPAGKM--------SKPFLQLAQDPTVPTYKQGILARKMHQDADGKKTPWGK 800
E G PFL + Q + TYK G+L RK H D DGK+TP G+
Sbjct: 477 LSELVDDKFGTGTKKVTRILDGGNPFLDVPQALSATTYKHGVLTRKTHADMDGKRTPRGR 536
Query: 801 RGWKMFHTLLRGMVLYFLKQGEDHCLEGESLVGQMVDEPVGVHHSLATPATHYTKKPHVF 860
RGWK F+ +L+G +LY K D ++L + + VHH+LAT A+ Y+KK +V
Sbjct: 537 RGWKKFYAVLKGTILYLQK---DEYRPDKALSEGDLKNAIRVHHALATRASDYSKKSNVL 593
Query: 861 QLRTADWRLYLFQAPTAKEMSSWIARINLAAATHSAPPFPAAVGSQRRFVRPILPVGPAQ 920
+L+TADWR++LFQAP+ +EM SWI RINL AA SAP FPAAV S ++F RP+LP +
Sbjct: 594 KLKTADWRVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTR 653
Query: 921 SSLEEQHRSHENCLDAAADDLLDLQRNLPERRGRGRELEEHRLRKEYLEYEKTRYETYVQ 980
EEQ RSHEN L +L + + + ER + +E EE+RL++ YL +EK+RYETY+
Sbjct: 654 LCQEEQLRSHENKLRQLTAELAEHRCHPVERGIKSKEAEEYRLKEHYLTFEKSRYETYIH 713
Query: 981 LLVARLHCPSDALDLWEEQLGREAGGTREPKLSLKKSHSSPSLHQ 1025
LL ++ SD L+ E +L G +P SL+K+HSSP+L Q
Sbjct: 714 LLAMKIKVGSDDLERIEARLATLEGD--DP--SLRKTHSSPALSQ 754
>gi|4758968 cytohesin 3 [Homo sapiens]
Length = 399
Score = 112 bits (281), Expect = 1e-24
Identities = 55/155 (35%), Positives = 95/155 (61%)
Query: 590 NLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649
++A LY+ EG K+ + YL + ++F+ V + ++ +F +L +ALR FL + L
Sbjct: 100 DVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLP 159
Query: 650 GETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFI 709
GE Q+ +R++ F+ R+ CNPG+F S D+ + L+ AI++LNT LH N+ + + FI
Sbjct: 160 GEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFI 219
Query: 710 TNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDE 744
G+ +GG+ P+ELL+ LY SI++E + D+
Sbjct: 220 AMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDD 254
>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
Length = 399
Score = 111 bits (277), Expect = 4e-24
Identities = 91/343 (26%), Positives = 150/343 (43%), Gaps = 75/343 (21%)
Query: 591 LASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLSG 650
+A LY+ EG K+ + YL + + + AV ++ +F +L +ALR FL + L G
Sbjct: 96 IARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPG 155
Query: 651 ETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFIT 710
E Q+ +R++ F++R+ CNPG+F S D+ + L+ A+++LNT LH N+ + F+
Sbjct: 156 EAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVA 215
Query: 711 NLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFLQLA 770
G+ +GG+ P+ELL+ LY SIR+E + D+ + P
Sbjct: 216 MNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPD-------------- 261
Query: 771 QDPTVPTYKQGILARKMHQDADGKKTPWGKRGWKMFHTLLRGMVLYFLKQGEDHCLEG-- 828
++G L + G+ W KR W +L LY+ + D G
Sbjct: 262 --------REGWLLK-----LGGRVKTW-KRRW----FILTDNCLYYFEYTTDKEPRGII 303
Query: 829 --ESLVGQMVDEPVGVHHSLATPATHYTKKPHVFQL--------------RTADWR---- 868
E+L + VD+P +KP+ F+L AD R
Sbjct: 304 PLENLSIREVDDP---------------RKPNCFELYIPNNKGQLIKACKTEADGRVVEG 348
Query: 869 ---LYLFQAPTAKEMSSWIARINLAAATHSAPPFPAAVGSQRR 908
+Y APT +E WI I A S PF + ++++
Sbjct: 349 NHMVYRISAPTQEEKDEWIKSIQAAV---SVDPFYEMLAARKK 388
>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
Length = 400
Score = 111 bits (277), Expect = 4e-24
Identities = 91/343 (26%), Positives = 150/343 (43%), Gaps = 74/343 (21%)
Query: 591 LASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLSG 650
+A LY+ EG K+ + YL + + + AV ++ +F +L +ALR FL + L G
Sbjct: 96 IARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPG 155
Query: 651 ETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFIT 710
E Q+ +R++ F++R+ CNPG+F S D+ + L+ A+++LNT LH N+ + F+
Sbjct: 156 EAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVA 215
Query: 711 NLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFLQLA 770
G+ +GG+ P+ELL+ LY SIR+E + D+ + P
Sbjct: 216 MNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPD-------------- 261
Query: 771 QDPTVPTYKQGILARKMHQDADGKKTPWGKRGWKMFHTLLRGMVLYFLKQGEDHCLEG-- 828
++G L + G+ W KR W +L LY+ + D G
Sbjct: 262 --------REGWLLKL----GGGRVKTW-KRRW----FILTDNCLYYFEYTTDKEPRGII 304
Query: 829 --ESLVGQMVDEPVGVHHSLATPATHYTKKPHVFQL--------------RTADWR---- 868
E+L + VD+P +KP+ F+L AD R
Sbjct: 305 PLENLSIREVDDP---------------RKPNCFELYIPNNKGQLIKACKTEADGRVVEG 349
Query: 869 ---LYLFQAPTAKEMSSWIARINLAAATHSAPPFPAAVGSQRR 908
+Y APT +E WI I A S PF + ++++
Sbjct: 350 NHMVYRISAPTQEEKDEWIKSIQAAV---SVDPFYEMLAARKK 389
>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
Length = 397
Score = 111 bits (277), Expect = 4e-24
Identities = 55/155 (35%), Positives = 94/155 (60%)
Query: 590 NLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649
++A LY+ EG K+ + YL + ++F+ V ++ +F +L +ALR FL + L
Sbjct: 96 DIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLP 155
Query: 650 GETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFI 709
GE Q+ +R++ F++R+ CN G+F S D+ + L+ AI++LNT LH N+ + + FI
Sbjct: 156 GEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFI 215
Query: 710 TNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDE 744
G+ DGG+ P+ELL+ LY SI++E + D+
Sbjct: 216 AMNRGINDGGDLPEELLRNLYESIKNEPFKIPEDD 250
>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
Length = 398
Score = 111 bits (277), Expect = 4e-24
Identities = 55/155 (35%), Positives = 94/155 (60%)
Query: 590 NLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649
++A LY+ EG K+ + YL + ++F+ V ++ +F +L +ALR FL + L
Sbjct: 96 DIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLP 155
Query: 650 GETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFI 709
GE Q+ +R++ F++R+ CN G+F S D+ + L+ AI++LNT LH N+ + + FI
Sbjct: 156 GEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFI 215
Query: 710 TNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDE 744
G+ DGG+ P+ELL+ LY SI++E + D+
Sbjct: 216 AMNRGINDGGDLPEELLRNLYESIKNEPFKIPEDD 250
>gi|7019505 cytohesin 4 [Homo sapiens]
Length = 394
Score = 100 bits (249), Expect = 7e-21
Identities = 50/157 (31%), Positives = 94/157 (59%), Gaps = 2/157 (1%)
Query: 590 NLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649
++A LY+ EG K+ + YL + + + V + ++ +F +L +ALR FL + L
Sbjct: 95 DIARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLP 154
Query: 650 GETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFI 709
GE Q+ +R++ F+ R+ CNPG+F S D+ + L+ +I++LNT LH N+ + F+
Sbjct: 155 GEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFV 214
Query: 710 TNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEED 746
+ G+ +G + P++ L+ L+ SI+SE +++ E+D
Sbjct: 215 SMNRGINNGSDLPEDQLRNLFDSIKSE--PFSIPEDD 249
>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
protein 1 [Homo sapiens]
Length = 1849
Score = 96.3 bits (238), Expect = 1e-19
Identities = 53/192 (27%), Positives = 99/192 (51%), Gaps = 2/192 (1%)
Query: 590 NLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649
++A L++ E ++V +L N+ F++ V Y+ F G+ ALR FL+ L
Sbjct: 732 DIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLP 791
Query: 650 GETQERERILYQFSRRFHHCNPG--IFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQE 707
GE Q+ +R++ +F+ R+ CN G +F S D+ + L +I++L TDLH + M+ ++
Sbjct: 792 GEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQ 851
Query: 708 FITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFL 767
+I G+ D + P+E L A+Y I +K+ +E T + ++ ++ + K +
Sbjct: 852 YIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQNVASEKQRRLLY 911
Query: 768 QLAQDPTVPTYK 779
L + T K
Sbjct: 912 NLEMEQMAKTAK 923
>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
Length = 1114
Score = 93.2 bits (230), Expect = 1e-18
Identities = 54/170 (31%), Positives = 95/170 (55%), Gaps = 8/170 (4%)
Query: 591 LASRLYRLEGFRKSEVAAYL-QKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649
+A L + +G + + +L + F+R V + + F LD ALR F + +
Sbjct: 545 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 604
Query: 650 GETQERERILYQFSRRFHHCNPGI---FPSVDSVHTLTCAIMLLNTDLHGQNI--GKSMS 704
GE Q+ ER++ FS+R+ CNPG+ F + D++ L AI+LLNTD++ N+ + M
Sbjct: 605 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 664
Query: 705 CQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQ 754
++FI NL G+ DG + P+E+L +Y IR +L+ +E+ ++ +K +
Sbjct: 665 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELK--TNEDHVSQVQKVE 712
>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
Length = 963
Score = 93.2 bits (230), Expect = 1e-18
Identities = 54/170 (31%), Positives = 95/170 (55%), Gaps = 8/170 (4%)
Query: 591 LASRLYRLEGFRKSEVAAYL-QKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649
+A L + +G + + +L + F+R V + + F LD ALR F + +
Sbjct: 559 VAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 618
Query: 650 GETQERERILYQFSRRFHHCNPGI---FPSVDSVHTLTCAIMLLNTDLHGQNI--GKSMS 704
GE Q+ ER++ FS+R+ CNPG+ F + D++ L AI+LLNTD++ N+ + M
Sbjct: 619 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMK 678
Query: 705 CQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQ 754
++FI NL G+ DG + P+E+L +Y IR +L+ +E+ ++ +K +
Sbjct: 679 LEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELK--TNEDHVSQVQKVE 726
>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
factor 2 [Homo sapiens]
Length = 1785
Score = 88.6 bits (218), Expect = 3e-17
Identities = 50/192 (26%), Positives = 97/192 (50%), Gaps = 2/192 (1%)
Query: 590 NLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649
++A L++ E ++V +L + F++ V Y+ F + ALR+FL+ L
Sbjct: 677 DIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLP 736
Query: 650 GETQERERILYQFSRRFHHCNPG--IFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQE 707
GE Q+ +R++ +F+ R+ CN G +F S D+ + L +I++L TDLH + M+ ++
Sbjct: 737 GEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQ 796
Query: 708 FITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFL 767
+I G+ D + P+E L ++Y I +K+ +E T + + ++ + K +
Sbjct: 797 YIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKELTIATKSTKQNVASEKQRRLLY 856
Query: 768 QLAQDPTVPTYK 779
L + T K
Sbjct: 857 NLEMEQMAKTAK 868
>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
Length = 759
Score = 88.6 bits (218), Expect = 3e-17
Identities = 51/155 (32%), Positives = 86/155 (55%), Gaps = 6/155 (3%)
Query: 591 LASRLYRLEGFRKSEVAAYL-QKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649
+A L + +G + + +L F+R V + + F LD ALR F + +
Sbjct: 383 VAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQ 442
Query: 650 GETQERERILYQFSRRFHHCNPGI---FPSVDSVHTLTCAIMLLNTDLHGQNI--GKSMS 704
GE Q+ ER++ FS+R+ CNP + F + D++ L AI+LLNTD++ NI + M
Sbjct: 443 GEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMM 502
Query: 705 CQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLE 739
++FI NL G+ DG + P+EL+ +Y I+ ++L+
Sbjct: 503 LEDFIRNLRGVDDGADIPRELVVGIYERIQQKELK 537
>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
exchange factor 1 [Homo sapiens]
Length = 1859
Score = 87.4 bits (215), Expect = 6e-17
Identities = 47/129 (36%), Positives = 78/129 (60%), Gaps = 5/129 (3%)
Query: 622 EEYLSFFQFGGQSLDRALRSFLQALVLSGETQERERILYQFSRRFHHCNPGIFPSVDSVH 681
E ++S F F G LD ALR +L+A L GE +R+L F+ R+ +CN F + D+
Sbjct: 765 ESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGSPFANSDACF 824
Query: 682 TLTCAIMLLNTDLHGQNIGKS---MSCQEFITNLNGLRDGGNFPKELLKALYWSIRSEKL 738
+L A+++LNTD H N+ K M+ +EF NL G+ G +F +++L+ +Y +I++E++
Sbjct: 825 SLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEI 884
Query: 739 EWAVDEEDT 747
+ EE T
Sbjct: 885 --VMPEEQT 891
>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
Length = 949
Score = 83.2 bits (204), Expect = 1e-15
Identities = 54/177 (30%), Positives = 91/177 (51%), Gaps = 11/177 (6%)
Query: 599 EGFRKSEVAAYL-QKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLSGETQERER 657
+G + + +L + F+R V + + F LD ALR F + + GE Q+ ER
Sbjct: 591 KGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVER 650
Query: 658 ILYQFSRRFHHCNPGI---FPSVDSVHTLTCAIMLLNTDLHGQNI--GKSMSCQEFITNL 712
++ FS+R+ CNP + F + D++ L AI+LLNTD++ ++ + M +FI NL
Sbjct: 651 LIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNL 710
Query: 713 NGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFLQL 769
G+ +G + P++LL +Y I+ +L +D +A + GK KP L L
Sbjct: 711 RGVDNGEDIPRDLLVGIYQRIQGRELR---TNDDHVSQVQAVERMIVGK--KPVLSL 762
>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
Length = 1488
Score = 83.2 bits (204), Expect = 1e-15
Identities = 54/177 (30%), Positives = 91/177 (51%), Gaps = 11/177 (6%)
Query: 599 EGFRKSEVAAYL-QKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLSGETQERER 657
+G + + +L + F+R V + + F LD ALR F + + GE Q+ ER
Sbjct: 796 KGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVER 855
Query: 658 ILYQFSRRFHHCNPGI---FPSVDSVHTLTCAIMLLNTDLHGQNI--GKSMSCQEFITNL 712
++ FS+R+ CNP + F + D++ L AI+LLNTD++ ++ + M +FI NL
Sbjct: 856 LIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNL 915
Query: 713 NGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFLQL 769
G+ +G + P++LL +Y I+ +L +D +A + GK KP L L
Sbjct: 916 RGVDNGEDIPRDLLVGIYQRIQGRELR---TNDDHVSQVQAVERMIVGK--KPVLSL 967
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 68.9 bits (167), Expect = 2e-11
Identities = 51/155 (32%), Positives = 73/155 (47%), Gaps = 15/155 (9%)
Query: 772 DPTVPTYKQGILARKMHQDADGKKTPWGKRGWKMFHTLLRGMVLYFLKQGEDHCLEGESL 831
+P+ +G+L RK +A GKK R W+ + +LR L F K + G
Sbjct: 2214 EPSAQEQMEGMLCRKQEMEAFGKKA--ANRSWQNVYCVLRRGSLGFYKDAKA-ASAGVPY 2270
Query: 832 VGQMVDEPVGVHHSLATPATHYTKKPHVFQLRTADWRLYLFQAPTAKEMSSWIARINLAA 891
G++ PV + + + A Y K+ HVF+L D + YLFQA EMSSW+ +N A
Sbjct: 2271 HGEV---PVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAI 2327
Query: 892 ATHSA----PPFPAAVGSQRRFVR-----PILPVG 917
AT S+ P P + R R P+ PVG
Sbjct: 2328 ATASSASGEPEEPVVPSTTRGMTRAMTMPPVSPVG 2362
Score = 32.0 bits (71), Expect = 3.2
Identities = 40/146 (27%), Positives = 57/146 (39%), Gaps = 15/146 (10%)
Query: 869 LYLFQAPTAKEMSSWIARINLAAATHSAPPFPAAVGSQRRFVRPILPVGPAQSSLEEQHR 928
LY FQA A +M +W+ A S+P S + R +LEE+ R
Sbjct: 749 LYQFQAD-ANDMEAWLVD---ALRLVSSPELGHDEFSTQALARQ-------HRALEEEIR 797
Query: 929 SHENCLDAAADDLLDLQRNL---PERRGRGRELEEHRLRKEYLEYEKTRYETYVQLLVAR 985
SH LDA + L L PE +GR LE H + E+ R L +
Sbjct: 798 SHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERAR-ALEAALALYT 856
Query: 986 LHCPSDALDLWEEQLGREAGGTREPK 1011
+ + A LW E+ + G P+
Sbjct: 857 MLSEAGACGLWVEEKEQWLNGLALPE 882
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 60.8 bits (146), Expect = 6e-09
Identities = 45/167 (26%), Positives = 73/167 (43%), Gaps = 14/167 (8%)
Query: 735 SEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFLQLAQDPTVPTYKQ--------GILARK 786
SE + A ++ +++ PS + + +K L T+P Q G L RK
Sbjct: 2148 SEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRK 2207
Query: 787 MHQDADGKKTPWGKRGWKMFHTLLRGMVLYFLKQGEDHCLEGESLVGQMVDEPVGVHHSL 846
+A KK R W + ++ + F K + S + + PV + ++
Sbjct: 2208 HEWEAHNKKA--SSRSWHNVYCVINNQEMGFYKDAKT----AASGIPYHSEVPVSLKEAV 2261
Query: 847 ATPATHYTKKPHVFQLRTADWRLYLFQAPTAKEMSSWIARINLAAAT 893
A Y KK HVF+LR D YLFQA +EM++WI I+ A ++
Sbjct: 2262 CEVALDYKKKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAISS 2308
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 59.3 bits (142), Expect = 2e-08
Identities = 43/149 (28%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 743 DEEDTARPEKAQPSLPAGKMSKPF-LQLAQDPTVPTYKQGILARKMHQDADGKKTPWGKR 801
DE T P P + +P L +D +G L RK D +G R
Sbjct: 2144 DERPTTEPLFKVLDTPLSEGDEPATLPAPRDHGQSVQMEGYLGRK--HDLEGPNKKASNR 2201
Query: 802 GWKMFHTLLRGMVLYFLKQGEDHCLEGESLVGQMVDEPVGVHHSLATPATHYTKKPHVFQ 861
W + +LR L F K ++ L G G+ EP+ + H++ A +Y KK HVF+
Sbjct: 2202 SWNNLYCVLRNSELTFYKDAKNLAL-GMPYHGE---EPLALRHAICEIAANYKKKKHVFK 2257
Query: 862 LRTADWRLYLFQAPTAKEMSSWIARINLA 890
LR ++ +LF +EM SW+ ++ A
Sbjct: 2258 LRLSNGSEWLFHGKDEEEMLSWLQGVSTA 2286
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
sapiens]
Length = 2564
Score = 54.3 bits (129), Expect = 6e-07
Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 7/123 (5%)
Query: 773 PTVPTYKQGILARKMHQDADGKKTPWGKRGWKMFHTLLRGMVLYFLKQGEDHCLEGESLV 832
PT +G L RK DA+ K + R W + +L L F K + G +
Sbjct: 2415 PTHTVQHEGFLLRKRELDANRKSS---NRSWVSLYCVLSKGELGFYKDSKGPA-SGSTHG 2470
Query: 833 GQMVDEPVGVHHSLATPATHYTKKPHVFQLRTADWRLYLFQAPTAKEMSSWIARINLAAA 892
G+ + + +H + + A+ Y KK HVF+L+T D +L QA +EM+ W+ + + A
Sbjct: 2471 GEPL---LSLHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWLEAVASSVA 2527
Query: 893 THS 895
H+
Sbjct: 2528 EHA 2530
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 53.5 bits (127), Expect = 1e-06
Identities = 57/193 (29%), Positives = 81/193 (41%), Gaps = 15/193 (7%)
Query: 701 KSMSCQEFITNLNGLRDGGNFPKELLKAL--YWSIRSEKLEWAVDEEDTARPEKAQPSLP 758
+S SC + LN RD G + L + +RS + ++D T+ A P
Sbjct: 526 RSKSCDD---GLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADA----P 578
Query: 759 AGKMSKPFLQLAQDPTVPTYKQGILARKMHQDADGKKTPWGKRGWKMFHTLLRGMVLYFL 818
+ + S L A + ++G L K GKK G R WK + LR L
Sbjct: 579 SKRHSTSDLSDATFSDIR--REGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLS 636
Query: 819 KQGEDH--CLEGESLVGQMVDE--PVGVHHSLATPATHYTKKPHVFQLRTADWRLYLFQA 874
K+ + G + G DE PV + L + TK+ HVF+L TAD+ YLFQA
Sbjct: 637 KERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQA 696
Query: 875 PTAKEMSSWIARI 887
+M WI I
Sbjct: 697 EDRDDMLGWIRAI 709
>gi|208022661 hypothetical protein LOC57701 [Homo sapiens]
Length = 1334
Score = 53.5 bits (127), Expect = 1e-06
Identities = 122/510 (23%), Positives = 172/510 (33%), Gaps = 96/510 (18%)
Query: 43 PEPFEEQTWATDPPEPTRQNVPPWGSGVELT--HLGSWVHQDGLEPCQEQTRATDPPEST 100
PEP + PEP+ PW + L +LG +H + L E T
Sbjct: 222 PEPINGELCGPPQPEPS-----PWAPCLLLGPGNLGGLLHWERL------LGGLGGEEDT 270
Query: 101 RQDAPPWGSGVELTHLGSPSAQREHRQNTASPGSPVNSHLPGSPKQNRSTSTQVVFWAGI 160
+ PWG G P AQ +PGS +S + N + S + A +
Sbjct: 271 GR---PWGPS-----RGPPQAQGTSSGPNCAPGSSSSSSSDEAGDPNEAPSPDTLLGA-L 321
Query: 161 LQAQMCVLDLEEELEKTEGLKAGLKCCLPTPPVDLPGDTGLHSSPPENEDSGEDSSEPEG 220
+ Q L+L + LE TE L+ L L GD H P G+ SS +
Sbjct: 322 ARRQ---LNLGQLLEDTESY---LQAFLAGAAGPLNGD---HPGP------GQSSSPDQA 366
Query: 221 EGQAWLREGTPDSSPQWGAEEESMFFSNPLFLASPCSENSASGECFSWGASDSHAGVRTG 280
Q +G P S+ G E P F A+ + GA D+ G R G
Sbjct: 367 PPQLSKSKGLPKSAWGGGTPEAH----RPGFGATSEGQGPLPFLSMFMGAGDAPLGSRPG 422
Query: 281 -PESPATLEPPLPEDTVLWELESEPDLGDGAAISGHCTPPFPVPIYKPHSICWASVAAAE 339
P S + ++ L P G+ P P P + +
Sbjct: 423 HPHSSSQVKSKLQI--------GPPSPGEAQG------PLLPSPARGLKFLKLPPTSEKS 468
Query: 340 GAPAAPPGHGESEGDRLGPAPSAAPCVDEALTWESGCVGSDLGPAAHPVQPWASLSPEGW 399
+P P + P S PC + SG GS A LSPEG
Sbjct: 469 PSPGGPQLSPQL------PRNSRIPCRN------SGSDGSPSPLLARRGLGGGELSPEGA 516
Query: 400 QRGGPFWPQVTLNSQDRDEREGGHPQESLPCTLAPCPWRSPASSPEPSSPESESRGPGPR 459
Q G P P + D + PQ +L TL+P P SP S RGP P
Sbjct: 517 Q-GLPTSPSPCYTTPDSTQLRP--PQSALSTTLSPGPVVSPCYENILDLSRSTFRGPSPE 573
Query: 460 PSPASSQEGSPQLQHHSSGILPKWTLDASQS-SLLETDGEQPS--------------SLK 504
P P+ Q + P+ TL+ Q+ +L + G PS
Sbjct: 574 PPPSPLQVPT----------YPQLTLEVPQAPEVLRSPGVPPSPCLPESYPYGSPQEKSL 623
Query: 505 KKEAGEAPKPGEEVKSEGTARPAETGDVQP 534
K E+P PG + +P++ +P
Sbjct: 624 DKAGSESPHPGRRTPGNSSKKPSQGSGRRP 653
>gi|48928044 F-box only protein 8 [Homo sapiens]
Length = 319
Score = 52.8 bits (125), Expect = 2e-06
Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 7/124 (5%)
Query: 615 DFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLSGETQER-ERILYQFSRRFHHCNPGI 673
D R V ++ ++ F Q L ALR F + + E E E ++ +FS RF CNP +
Sbjct: 190 DERRDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDL 249
Query: 674 FP----SVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFITNLNGLRDGGNFPKELLKAL 729
S D+V+ L +++LL+ DL ++ MS +EFI N R N ++ + L
Sbjct: 250 MRELGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTR--RAAQNISEDFVGHL 307
Query: 730 YWSI 733
Y +I
Sbjct: 308 YDNI 311
>gi|41281612 zinc finger protein 828 [Homo sapiens]
Length = 812
Score = 51.6 bits (122), Expect = 4e-06
Identities = 80/302 (26%), Positives = 111/302 (36%), Gaps = 62/302 (20%)
Query: 285 ATLEPPLPEDTVLWELESEPDLGDGAAISGHCTPPFPVPIYKPHSICWASVAAAEGAPAA 344
+ L P P+ T L LE + G+ +S P P P +P S A+ +P
Sbjct: 139 SVLSPESPKPTPLTPLEPQKP---GSVVSPELQTPLPSP--EP------SKPASVSSPEP 187
Query: 345 PPGHGESEGDRLGPAPSAAPCVDEALTWES-------------GCVGSDLGP--AAHPVQ 389
P E +L P PS P ++ ES LGP A+ P
Sbjct: 188 PKSVPVCESQKLAPVPSPEPQKPAPVSPESVKATLSNPKPQKQSHFPETLGPPSASSPES 247
Query: 390 PWASLSPEGWQRGGPFWPQVTLNSQDRDEREGGHPQESLPCTLAPCPWRS-PASSPEPSS 448
P + SPE W GP P + S+ P++ P + +P PW+ PA SPEP
Sbjct: 248 PVLAASPEPW---GPS-PAASPESRKSARTTSPEPRKPSP-SESPEPWKPFPAVSPEP-- 300
Query: 449 PESESRGPGPRPSPASSQEGSPQLQHHSSGILPKWTLDASQSSLLETDGEQPSSLKKKEA 508
R P P SP S + G P G W + S SS P K
Sbjct: 301 -----RRPAPAVSPGSWKPGPP-------GSPRPWKSNPSASS-------GPWKPAKPAP 341
Query: 509 GEAPKPGEEVKSEGTARPAETGDVQPDIHLTSAEHENLRTPMNSSWL--PGSPMPQAQSP 566
+P P + + S G +P ++SA ++ + SSW P SP P
Sbjct: 342 SVSPGPWKPIPS------VSPGPWKPTPSVSSASWKS-SSVSPSSWKSPPASPESWKSGP 394
Query: 567 EE 568
E
Sbjct: 395 PE 396
Score = 37.4 bits (85), Expect = 0.075
Identities = 58/228 (25%), Positives = 79/228 (34%), Gaps = 28/228 (12%)
Query: 358 PAPSAAPCVDEALTWESGCVGSDLGPAAHPVQPWASLSPEGWQRGGPFWP--QVTLNSQD 415
P SA P AL+ E+ +GS L P + P L P+ + G P Q L S +
Sbjct: 118 PCNSAEPKSIPALSMETQKLGSVLSPESPKPTPLTPLEPQ--KPGSVVSPELQTPLPSPE 175
Query: 416 RDER---EGGHPQESLPC----TLAPCPWRSPASSPEPSSPES------------ESRGP 456
+ P +S+P LAP P P P P SPES +S P
Sbjct: 176 PSKPASVSSPEPPKSVPVCESQKLAPVPSPEP-QKPAPVSPESVKATLSNPKPQKQSHFP 234
Query: 457 GPRPSPASSQEGSPQLQHHSSGILPKWTLDASQSSLLETDGEQPSSLKKKEAGEAPKPGE 516
P++S SP L P T +P E+ E KP
Sbjct: 235 ETLGPPSASSPESPVLAASPEPWGPSPAASPESRKSARTTSPEPRKPSPSESPEPWKPFP 294
Query: 517 EVKSEGTARPA---ETGDVQPDIHLTSAEHENLRTPMNSSWLPGSPMP 561
V E RPA G +P + ++ + + W P P P
Sbjct: 295 AVSPE-PRRPAPAVSPGSWKPGPPGSPRPWKSNPSASSGPWKPAKPAP 341
Score = 30.8 bits (68), Expect = 7.0
Identities = 102/477 (21%), Positives = 163/477 (34%), Gaps = 53/477 (11%)
Query: 87 CQEQTRATDPPESTRQDAPPWGSGVELTHLGSPSAQRE-HRQNTASPGSPVNSHLPGSPK 145
C+ Q A P ++ AP V+ T L +P Q++ H T P S + P SP
Sbjct: 194 CESQKLAPVPSPEPQKPAPVSPESVKAT-LSNPKPQKQSHFPETLGPPSASS---PESPV 249
Query: 146 QNRSTSTQVVFWAGILQAQMCVLDLEEELEKTEGLKAGLKCCLPTPPVDLPGDTGLHSSP 205
S A +++ E K ++ P P P + P
Sbjct: 250 LAASPEPWGPSPAASPESRKSARTTSPEPRKPSPSES------PEPWKPFPAVSPEPRRP 303
Query: 206 PENEDSGEDSSEPEGEGQAWLREGTPDSSPQWGAEEESMFFSNPLFLASPCSENSASGEC 265
G P G + W + S P W + + S + P S S
Sbjct: 304 APAVSPGSWKPGPPGSPRPWKSNPSASSGP-WKPAKPAPSVSPGPWKPIP----SVSPGP 358
Query: 266 FSWGASDSHAGVRTGPESPATLEPPLPEDTVLWELESEPDLGDGAAISG----HCTPPFP 321
+ S S A ++ SP++ + P P W+ P+L A PP
Sbjct: 359 WKPTPSVSSASWKSSSVSPSSWKSP-PASPESWK-SGPPELRKTAPTLSPEHWKAVPPVS 416
Query: 322 VPIYKPHSICWASVAAAEGAPAAPPGHGESEGDRLGP--APSAAPCVDEALTWESGCVGS 379
+ KP + + G+P G + +L P ++ +D + +S GS
Sbjct: 417 PELRKPGPPLSPEIRSPAGSPELRKPSGSPDLWKLSPDQRKTSPASLDFPESQKSSRGGS 476
Query: 380 -DLGPAAHPVQPWASLSPEGWQRGGPFWPQVTLNSQDRDEREGGHPQESLPCT-LAPCPW 437
DL ++ ++P + PE ++ GP P + + + P S+ P +
Sbjct: 477 PDLWKSSFFIEPQKPVFPET-RKPGPSGP----SESPKAASDIWKPVLSIDTEPRKPALF 531
Query: 438 RSPASSPEPSSPESESRGPGPRPS--------PASSQEGSPQ-------------LQHHS 476
PA + P+SPE+ R P P P S+ Q +
Sbjct: 532 PEPAKTAPPASPEARKRALFPEPRKHALFPELPKSALFSESQKAVELGDELQIDAIDDQK 591
Query: 477 SGILPKWTLDASQSSLLETDGEQPSSLKKKEAGEAPKPGEEVKSEGTARPAETGDVQ 533
IL + L AS LLE D PSS K K+ + E SE + D++
Sbjct: 592 CDILVQEELLASPKKLLE-DTLFPSSKKLKKDNQESSDAELSSSEYIKTDLDAMDIK 647
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 49.7 bits (117), Expect = 1e-05
Identities = 142/616 (23%), Positives = 205/616 (33%), Gaps = 137/616 (22%)
Query: 8 PDHPQPMEILNLYLGDS---LEPH-----PGECPRETCSHEDPPEPFEEQTWATDPPEPT 59
P P P++ LG + LEP E P E P P E++ + PPE +
Sbjct: 406 PKEPGPLQCEAKPLGKAGVQLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEAS 465
Query: 60 RQNVPPWGSGV----ELTHLGSWVHQDGLEPCQEQTRATDPPESTRQDAPPWGSGVELTH 115
R + PP E HL + + L P E++ + PPES+ P+ S +E +
Sbjct: 466 RLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESS-----PF-SPLEESP 519
Query: 116 LGSPSAQREHRQNTASPGSPVNSHLPGSPKQNRSTSTQVVFWAGILQAQMCVLDLEEELE 175
L P SP SP P SP S L E
Sbjct: 520 LSPPE---------ESPPSPA-LETPLSPPPEAS-------------------PLSPPFE 550
Query: 176 KTEGLKAGLKCCLPTPPVDLPGDTGLHSSPPENEDSGEDSSEPEGEGQAWLREGTPDSSP 235
++ L PP +LP +SPP ++ S PE + E +P S P
Sbjct: 551 ESP---------LSPPPEELP------TSPP--PEASRLSPPPEESPMSPPPEESPMSPP 593
Query: 236 QWGAEEESMFFSNPLFLASPCSENSASGECFSWGASDSHAGVRTGPESPATLEPPLPEDT 295
+ F +PL SP E S + A + P + + PP PE++
Sbjct: 594 PEASRLFPPFEESPL---SPPPEESPL-------SPPPEASRLSPPPEDSPMSPP-PEES 642
Query: 296 VLWELESEPDLGDGAAISGHCTPPFPVPIYKPHSICWASVAAAEGAPAAPPGHGESEGDR 355
+ L +S PP P+ P E +P +PP E R
Sbjct: 643 PMSPPPEVSRLSPLPVVSRLSPPPEESPLSPP----------PEESPTSPP----PEASR 688
Query: 356 LGPAPS------------AAPCVDEAL----TWESGCVGSDLGPAAHPVQPWASLSPEGW 399
L P P A+P +++L ES + P P LSP
Sbjct: 689 LSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPE 748
Query: 400 Q-RGGPFWPQVTLNSQDRDEREGGHPQESLPCTLAPCPWRSPAS-----SPEPSS----- 448
+ P + L+ Q + P+E C + P SP + SP+P
Sbjct: 749 EPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSP 808
Query: 449 ----------PESESRGPGPRPSPASSQEGSPQL-----QHHSSGILPKWTLDASQSSLL 493
PE P P S S Q P L + H S L K L
Sbjct: 809 QTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPP 868
Query: 494 ETDGEQPSSLKKKEAGEAPKPGEEVKSEGTARPAETGDVQPDIHLTSAE---HENLRTPM 550
E G+ P+ +E P PGE S PA + +P + E + +
Sbjct: 869 EEPGQCPA---PEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSL 925
Query: 551 NSSWLPGSPMPQAQSP 566
+ +P P+P SP
Sbjct: 926 SPQLMPPDPLPPPLSP 941
Score = 48.1 bits (113), Expect = 4e-05
Identities = 122/493 (24%), Positives = 151/493 (30%), Gaps = 85/493 (17%)
Query: 11 PQPMEILNLYLGDSLEPHPGECPRETCSHEDPPEPFEEQTWATDPPEPTRQNVPPWGSGV 70
P+ + + L P P E P P E + + PPE + + PP
Sbjct: 594 PEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPP----- 648
Query: 71 ELTHLGSWVHQDGLEPCQEQTRATDPPESTRQDAPPWGSGVELTHLGSPSAQREHRQNTA 130
E++ L L P E++ + PPE + PP E + L P
Sbjct: 649 EVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPP-----EASRLSPPPED-------- 695
Query: 131 SPGSPVNSHLPGSPKQNRSTSTQVVFWAGILQAQMCVLDLEEELEKTEGLKAGLKCCLPT 190
SP SP P SP S + L LEE LP
Sbjct: 696 SPTSPPPEDSPASPPPEDS---------------LMSLPLEE----------SPLLPLPE 730
Query: 191 PPVDLPGDTGLHSSP-PENEDSGEDSSEPEGEGQAWLREGTPDSSPQWGAEEESMFFSNP 249
P P G H SP PE EP QA P SPQ EE + P
Sbjct: 731 EPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQA----EEPHLSPQ---PEEPCLCAVP 783
Query: 250 LFLASPCSENSASGECFSWGASDSHAGVRTGPE--SPATLEP---PLPEDTVLWELESEP 304
P A G S + H +T SP EP P PE++ L EP
Sbjct: 784 ---EEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEP 840
Query: 305 DLGDGAAISGHCTPPFPVPIYKPHSIC----WASVAAAEGAPAAPPGHGESEGDRLG-PA 359
L S H +P P P A E P PP S LG PA
Sbjct: 841 CLSPRPEES-HLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPA 899
Query: 360 ------PSAAPCVDEALTWESGCVGSDLGPAAHPVQPW-ASLSPEGWQRGGPFWPQVTLN 412
P +P +E SG L P P P LSP P +
Sbjct: 900 LSEPGEPPLSPLPEELPLSPSG--EPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGEL 957
Query: 413 SQDRDEREGGHPQESLPCTLAPCPWRSP----ASSPEPSSPESESRGPGPRPSPAS---- 464
+ P+ L + P P + PEP P PG PAS
Sbjct: 958 EYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPVGPASPILM 1017
Query: 465 ---SQEGSPQLQH 474
+ SP LQH
Sbjct: 1018 EPLPPQCSPLLQH 1030
Score = 45.4 bits (106), Expect = 3e-04
Identities = 120/496 (24%), Positives = 160/496 (32%), Gaps = 75/496 (15%)
Query: 11 PQPMEILNLYLGDSLEPHPGECPRETCSHEDPPEPFEEQTWATDPPEPTRQNVPPWGSGV 70
P+ + L + L P P E P E P P E + + PPE + + PP S
Sbjct: 648 PEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPA 707
Query: 71 ----ELTHLGSWVHQDGLEPCQEQT----RATDPPESTRQDAPPWGSGVELTHLGSPSAQ 122
E + + + + L P E+ R+ P S R + P E HL SP A+
Sbjct: 708 SPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHL-SPQAE 766
Query: 123 REHRQNTASPGSPVNSHLPGSPKQNRSTSTQVVFWAGILQAQMCVLDLEEELEKTEGLKA 182
H + P P +P P + L Q L L + E+
Sbjct: 767 EPHL--SPQPEEPCLCAVPEEPHLSPQAE------GPHLSPQPEELHLSPQTEEPHLSPV 818
Query: 183 GLKCCLPTPPVDL------------PGDTGLHSSPPENED--SGEDSSEPEGEGQAWLRE 228
+ CL P + P H SP + S PE GQ E
Sbjct: 819 PEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPE 878
Query: 229 --------GTPDSSPQWGAEEESMFFSNPLFLASPCSEN---SASGECFSWGASDSHAGV 277
G P SP G S PL SP E S SGE S
Sbjct: 879 ELPLFPPPGEPSLSPLLGEPALSEPGEPPL---SPLPEELPLSPSGEP-SLSPQLMPPDP 934
Query: 278 RTGPESPATLEPPLPEDTVLWELESEPDL-GDGAAISGHCTPPFPVPIYKPHSICWASVA 336
P SP P + L ELE GD S P PI P
Sbjct: 935 LPPPLSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPP-----PEAN 989
Query: 337 AAEGAPAAPPGHGESEGDRLGPA---------PSAAPCVDEALTWESGCVGSDLGPAAHP 387
+ P P S G +GPA P +P + +L ++ S P A P
Sbjct: 990 CTDPEPVPPMILPPSPGSPVGPASPILMEPLPPQCSPLLQHSLVPQNS-PPSQCSPPALP 1048
Query: 388 VQPWASLSPEGWQRGGPFWPQVTLNSQDRDEREGGHPQESLPCTLAPCPWRSPASSPEPS 447
+ + LSP G G DE E H E+ + CP P+++
Sbjct: 1049 LSVPSPLSPIGKVVGVS------------DEAEL-HEMETEKVSEPECPALEPSATSPLP 1095
Query: 448 SPESESRGPGPRPSPA 463
SP + P P P+PA
Sbjct: 1096 SPMGDLSCPAPSPAPA 1111
Score = 41.6 bits (96), Expect = 0.004
Identities = 74/300 (24%), Positives = 101/300 (33%), Gaps = 43/300 (14%)
Query: 281 PESPATLE---PPLPEDTVLWELESEPDLGDGAAISGHCTPPFPVPIYKPHSICWASVAA 337
P+ P L+ PL + V E + E L + + PP P+ P
Sbjct: 406 PKEPGPLQCEAKPLGKAGVQLEPQLEAPLNEEMPL---LPPPEESPLSPP---------- 452
Query: 338 AEGAPAAPPGHGESEGDRLGPAPSAAPC--VDEALTWESGCVGSDLGPAAHPVQPWASLS 395
E +P +PP E RL P P P + EAL S L P P + S
Sbjct: 453 PEESPTSPP----PEASRLSPPPEELPASPLPEALHLSRPLEESPLSPP--PEESPLSPP 506
Query: 396 PEGWQRGGPFWPQVTLNSQDRDEREGGHPQESLPCTLAPCPWRSPASSPEPSSPESESRG 455
PE PF P L E P +L L+P P SP S P SP S
Sbjct: 507 PES----SPFSP---LEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPE 559
Query: 456 PGPRPSPASSQEGSPQLQHHSSGILPK---WTLDASQSSLLETDGEQPSSLKKKEAGEAP 512
P P + SP + P+ + S L E P S +E+ +P
Sbjct: 560 ELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSP 619
Query: 513 KPGEEVKSEGTARPAETGDVQPDIHLTSAEHENLRTPMNSSWLPGSPMPQAQSPEEGQRP 572
P ++ + P E + P E + P S L P+ SP + P
Sbjct: 620 PP----EASRLSPPPEDSPMSP-----PPEESPMSPPPEVSRLSPLPVVSRLSPPPEESP 670
Score = 33.9 bits (76), Expect = 0.83
Identities = 40/156 (25%), Positives = 58/156 (37%), Gaps = 21/156 (13%)
Query: 439 SPA-SSPEPSSPESESRGPGPRPSPASSQEGSPQLQHHSSGILPKWTLDASQS--SLLET 495
SPA + EP E+E G + S + P +LP +TL + SLL+
Sbjct: 4822 SPARAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDILSLLKQ 4881
Query: 496 DGEQPS---------SLKKKEAGEAPKPGEEVKSEGTARPAETGDVQPDIHLTSAEHENL 546
+ P ++ + + P E S + A + P L E L
Sbjct: 4882 ESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPL 4941
Query: 547 RTPMNSSWLP-------GSPMPQAQSPEEGQ--RPP 573
P S LP P P+A+ PEEG+ RPP
Sbjct: 4942 AEPPVPSPLPLASSPESARPKPRARPPEEGEDSRPP 4977
Score = 33.1 bits (74), Expect = 1.4
Identities = 41/160 (25%), Positives = 56/160 (35%), Gaps = 13/160 (8%)
Query: 425 QESLPCTLAPCPWRSPASSPEPSSPESESRGPGPRPSPASSQEGSPQLQHHSSGILPKWT 484
Q S L P P + A P P +P +S P RP P+ Q P H
Sbjct: 2418 QSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRP-PSRPQSRDPFAPLHKPPRPQPPE 2476
Query: 485 LDASQSSLLETD---GEQPSSLKKKEAGE------APKPGEEVKSEGTARPAETGDVQPD 535
+ SL T G P++L AGE + +P V+S GT T
Sbjct: 2477 VAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRF 2536
Query: 536 IHLTSAEHENLRTPMNSSWLPGSPMPQAQSPEEGQRPPAG 575
+ +L+ P+ PG P P + G P G
Sbjct: 2537 TFPQAVGEPSLKPPVPQ---PGLPPPHGINSHFGPGPTLG 2573
>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
sapiens]
Length = 503
Score = 49.3 bits (116), Expect = 2e-05
Identities = 76/308 (24%), Positives = 101/308 (32%), Gaps = 56/308 (18%)
Query: 276 GVRTGPESPATLEPPLPEDTVLWELESEPDLGDGAAISGHCTPPFPVPIYK-PHSICWAS 334
G R+GP P P P PD+G P P PI PH+
Sbjct: 156 GHRSGPPEPQRNRMPPPR----------PDVGSKPDSIPPPVPSTPRPIQSSPHN----- 200
Query: 335 VAAAEGAPAAPPGHGESEGDRLGPAPSAAPCVDEALTWESGCVGSDLGPAAHPVQPWASL 394
G+P P G + GP P P G G+ LG + P +S
Sbjct: 201 ----RGSPPVPGGPRQPSP---GPTPPPFP----------GNRGTALGGGSIRQSPLSSS 243
Query: 395 SPEGWQRGGPFWPQVTLNSQDRDEREGGHPQESLPCTLAPCPWRSPASSPEPSSPESESR 454
SP + P P L+ + + S+ P P P PS+P +
Sbjct: 244 SPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSAS 303
Query: 455 GPGPRPSPASSQEGSPQLQHHSSG-----ILPKWTLDASQSSLLETDGEQPSSLKKKEAG 509
P P P S+ G P L SSG LP+ L S S+ P +
Sbjct: 304 SQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSST-------PPLPSPGRSGP 356
Query: 510 EAPKPGEEVKSEGTARPAETGDVQPDIHLTSAEHENLRTPMNSSWLPGSP-MPQ---AQS 565
P P E P +G + P ++ R S LP +P +P S
Sbjct: 357 LPPPPSERPPPPVRDPPGRSGPLPPPPPVS-------RNGSTSRALPATPQLPSRSGVDS 409
Query: 566 PEEGQRPP 573
P G RPP
Sbjct: 410 PRSGPRPP 417
Score = 32.3 bits (72), Expect = 2.4
Identities = 58/224 (25%), Positives = 78/224 (34%), Gaps = 41/224 (18%)
Query: 269 GASDSHAGVRTGP---ESPATLEPPLPEDTVLWELESEPD-----LGDGAAISGHCTPPF 320
G + +R P SP + PPLP T L+ +P +G+ +I PP
Sbjct: 227 GTALGGGSIRQSPLSSSSPFSNRPPLPP-TPSRALDDKPPPPPPPVGNRPSIHREAVPPP 285
Query: 321 PVPIYKPHSICWASVAAAEGAPAAPPGHGESEGDRLGPAPSAAPCVDEA--LTWESGCVG 378
P KP +A+ AP PP L P+ S DE L + +
Sbjct: 286 PPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGN---DETPRLPQRNLSLS 342
Query: 379 SDLGPAAHPVQ------------PWASLSPEGWQRGGPFWPQVTLNSQDRDEREGGHPQE 426
S P P + P P G R GP P ++ G
Sbjct: 343 SSTPPLPSPGRSGPLPPPPSERPPPPVRDPPG--RSGPLPPPPPVS-------RNGSTSR 393
Query: 427 SLPCTLAPCPWRS----PASSPEPS-SPESESRGPGPRPSPASS 465
+LP T P RS P S P P P+ S G P P P++S
Sbjct: 394 ALPAT-PQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTS 436
>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
sapiens]
Length = 503
Score = 49.3 bits (116), Expect = 2e-05
Identities = 76/308 (24%), Positives = 101/308 (32%), Gaps = 56/308 (18%)
Query: 276 GVRTGPESPATLEPPLPEDTVLWELESEPDLGDGAAISGHCTPPFPVPIYK-PHSICWAS 334
G R+GP P P P PD+G P P PI PH+
Sbjct: 156 GHRSGPPEPQRNRMPPPR----------PDVGSKPDSIPPPVPSTPRPIQSSPHN----- 200
Query: 335 VAAAEGAPAAPPGHGESEGDRLGPAPSAAPCVDEALTWESGCVGSDLGPAAHPVQPWASL 394
G+P P G + GP P P G G+ LG + P +S
Sbjct: 201 ----RGSPPVPGGPRQPSP---GPTPPPFP----------GNRGTALGGGSIRQSPLSSS 243
Query: 395 SPEGWQRGGPFWPQVTLNSQDRDEREGGHPQESLPCTLAPCPWRSPASSPEPSSPESESR 454
SP + P P L+ + + S+ P P P PS+P +
Sbjct: 244 SPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSAS 303
Query: 455 GPGPRPSPASSQEGSPQLQHHSSG-----ILPKWTLDASQSSLLETDGEQPSSLKKKEAG 509
P P P S+ G P L SSG LP+ L S S+ P +
Sbjct: 304 SQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSST-------PPLPSPGRSGP 356
Query: 510 EAPKPGEEVKSEGTARPAETGDVQPDIHLTSAEHENLRTPMNSSWLPGSP-MPQ---AQS 565
P P E P +G + P ++ R S LP +P +P S
Sbjct: 357 LPPPPSERPPPPVRDPPGRSGPLPPPPPVS-------RNGSTSRALPATPQLPSRSGVDS 409
Query: 566 PEEGQRPP 573
P G RPP
Sbjct: 410 PRSGPRPP 417
Score = 32.3 bits (72), Expect = 2.4
Identities = 58/224 (25%), Positives = 78/224 (34%), Gaps = 41/224 (18%)
Query: 269 GASDSHAGVRTGP---ESPATLEPPLPEDTVLWELESEPD-----LGDGAAISGHCTPPF 320
G + +R P SP + PPLP T L+ +P +G+ +I PP
Sbjct: 227 GTALGGGSIRQSPLSSSSPFSNRPPLPP-TPSRALDDKPPPPPPPVGNRPSIHREAVPPP 285
Query: 321 PVPIYKPHSICWASVAAAEGAPAAPPGHGESEGDRLGPAPSAAPCVDEA--LTWESGCVG 378
P KP +A+ AP PP L P+ S DE L + +
Sbjct: 286 PPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGN---DETPRLPQRNLSLS 342
Query: 379 SDLGPAAHPVQ------------PWASLSPEGWQRGGPFWPQVTLNSQDRDEREGGHPQE 426
S P P + P P G R GP P ++ G
Sbjct: 343 SSTPPLPSPGRSGPLPPPPSERPPPPVRDPPG--RSGPLPPPPPVS-------RNGSTSR 393
Query: 427 SLPCTLAPCPWRS----PASSPEPS-SPESESRGPGPRPSPASS 465
+LP T P RS P S P P P+ S G P P P++S
Sbjct: 394 ALPAT-PQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTS 436
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.131 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,673,535
Number of Sequences: 37866
Number of extensions: 3412571
Number of successful extensions: 17629
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 762
Number of HSP's that attempted gapping in prelim test: 14410
Number of HSP's gapped (non-prelim): 3327
length of query: 1056
length of database: 18,247,518
effective HSP length: 113
effective length of query: 943
effective length of database: 13,968,660
effective search space: 13172446380
effective search space used: 13172446380
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.