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Search of human proteins with 56243599
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56243599 WD repeat domain 35 isoform 2 [Homo sapiens]
(1170 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56243599 WD repeat domain 35 isoform 2 [Homo sapiens] 2375 0.0
gi|55743161 WD repeat domain 35 isoform 1 [Homo sapiens] 2366 0.0
gi|55953102 tubby like protein 4 isoform 2 [Homo sapiens] 144 5e-34
gi|55953100 tubby like protein 4 isoform 1 [Homo sapiens] 144 5e-34
gi|16554625 WD repeat domain 10 isoform 4 [Homo sapiens] 64 6e-10
gi|16554621 WD repeat domain 10 isoform 1 [Homo sapiens] 64 6e-10
gi|16554619 WD repeat domain 10 isoform 3 [Homo sapiens] 64 6e-10
gi|16554623 WD repeat domain 10 isoform 2 [Homo sapiens] 64 6e-10
gi|46409657 WD repeat domain 56 [Homo sapiens] 47 1e-04
gi|21536485 HIR histone cell cycle regulation defective homolog ... 46 2e-04
gi|46358428 selective LIM binding factor homolog [Homo sapiens] 46 2e-04
gi|4885105 chromatin assembly factor 1 subunit B [Homo sapiens] 44 7e-04
gi|14150171 THO complex 3 [Homo sapiens] 43 0.002
gi|169403944 WD repeat domain 26 isoform b [Homo sapiens] 41 0.006
gi|55743153 WD repeat domain 26 isoform a [Homo sapiens] 41 0.006
gi|5902134 coronin, actin binding protein, 1A [Homo sapiens] 41 0.008
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 40 0.013
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 40 0.013
gi|7656991 coronin, actin binding protein, 1C isoform 1 [Homo sa... 40 0.017
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 39 0.029
gi|14149696 SEC31 homolog B [Homo sapiens] 39 0.029
gi|23199987 WD repeat domain 5B [Homo sapiens] 39 0.029
gi|41281447 intraflagellar transport 140 [Homo sapiens] 39 0.038
gi|16554629 WD repeat domain 5 [Homo sapiens] 38 0.049
gi|16554627 WD repeat domain 5 [Homo sapiens] 38 0.049
gi|109627650 coronin 6 [Homo sapiens] 38 0.049
gi|13376840 WD repeat domain 61 [Homo sapiens] 38 0.049
gi|16418439 WD repeat and FYVE domain containing 2 [Homo sapiens] 38 0.049
gi|32699064 WD repeat domain 53 [Homo sapiens] 38 0.065
gi|65787364 coronin, actin binding protein, 1B [Homo sapiens] 38 0.065
>gi|56243599 WD repeat domain 35 isoform 2 [Homo sapiens]
Length = 1170
Score = 2375 bits (6154), Expect = 0.0
Identities = 1170/1170 (100%), Positives = 1170/1170 (100%)
Query: 1 MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSN 60
MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSN
Sbjct: 1 MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSN 60
Query: 61 LSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRS 120
LSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRS
Sbjct: 61 LSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRS 120
Query: 121 MSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEI 180
MSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEI
Sbjct: 121 MSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEI 180
Query: 181 HIYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAVCFDNGRCQIMR 240
HIYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAVCFDNGRCQIMR
Sbjct: 181 HIYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAVCFDNGRCQIMR 240
Query: 241 HENDQNPVLIDTGMYVVGIQWNHMGSVLAVAGFQKAAMQDKDVNIVQFYTPFGEHLGTLK 300
HENDQNPVLIDTGMYVVGIQWNHMGSVLAVAGFQKAAMQDKDVNIVQFYTPFGEHLGTLK
Sbjct: 241 HENDQNPVLIDTGMYVVGIQWNHMGSVLAVAGFQKAAMQDKDVNIVQFYTPFGEHLGTLK 300
Query: 301 VPGKEISALSWEGGGLKIALAVDSFIYFANIRPNYKWGYCSNTVVYAYTRPDRPEYCVVF 360
VPGKEISALSWEGGGLKIALAVDSFIYFANIRPNYKWGYCSNTVVYAYTRPDRPEYCVVF
Sbjct: 301 VPGKEISALSWEGGGLKIALAVDSFIYFANIRPNYKWGYCSNTVVYAYTRPDRPEYCVVF 360
Query: 361 WDTKNNEKYVKYVKGLISITTCGDFCILATKADENHPQFVLVLCNSIGTPLDPKYIDIVP 420
WDTKNNEKYVKYVKGLISITTCGDFCILATKADENHPQFVLVLCNSIGTPLDPKYIDIVP
Sbjct: 361 WDTKNNEKYVKYVKGLISITTCGDFCILATKADENHPQFVLVLCNSIGTPLDPKYIDIVP 420
Query: 421 LFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDTPSGSMD 480
LFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDTPSGSMD
Sbjct: 421 LFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDTPSGSMD 480
Query: 481 GVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQKYSLNCRAYQLSL 540
GVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQKYSLNCRAYQLSL
Sbjct: 481 GVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQKYSLNCRAYQLSL 540
Query: 541 NCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMKWAKDNPDLFAM 600
NCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMKWAKDNPDLFAM
Sbjct: 541 NCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMKWAKDNPDLFAM 600
Query: 601 MEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSL 660
MEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSL
Sbjct: 601 MEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSL 660
Query: 661 RDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFV 720
RDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFV
Sbjct: 661 RDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFV 720
Query: 721 KRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGS 780
KRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGS
Sbjct: 721 KRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGS 780
Query: 781 GDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAIS 840
GDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAIS
Sbjct: 781 GDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAIS 840
Query: 841 LPENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMK 900
LPENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMK
Sbjct: 841 LPENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMK 900
Query: 901 EIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIADEEAKKGSKPLRVKKLY 960
EIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIADEEAKKGSKPLRVKKLY
Sbjct: 901 EIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIADEEAKKGSKPLRVKKLY 960
Query: 961 VLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLSTTDRFTDNAWRGAEAYH 1020
VLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLSTTDRFTDNAWRGAEAYH
Sbjct: 961 VLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLSTTDRFTDNAWRGAEAYH 1020
Query: 1021 FFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCACASRAFGTCSKAFIKL 1080
FFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCACASRAFGTCSKAFIKL
Sbjct: 1021 FFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCACASRAFGTCSKAFIKL 1080
Query: 1081 KSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTCVATGSPITEYQ 1140
KSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTCVATGSPITEYQ
Sbjct: 1081 KSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTCVATGSPITEYQ 1140
Query: 1141 FWMCSVCKHGVLAQEISHYSFCPLCHSPVG 1170
FWMCSVCKHGVLAQEISHYSFCPLCHSPVG
Sbjct: 1141 FWMCSVCKHGVLAQEISHYSFCPLCHSPVG 1170
>gi|55743161 WD repeat domain 35 isoform 1 [Homo sapiens]
Length = 1181
Score = 2366 bits (6132), Expect = 0.0
Identities = 1170/1181 (99%), Positives = 1170/1181 (99%), Gaps = 11/1181 (0%)
Query: 1 MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSN 60
MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSN
Sbjct: 1 MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSN 60
Query: 61 LSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRS 120
LSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRS
Sbjct: 61 LSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRS 120
Query: 121 MSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEI 180
MSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEI
Sbjct: 121 MSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEI 180
Query: 181 HIYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAVCFDNGRCQIMR 240
HIYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAVCFDNGRCQIMR
Sbjct: 181 HIYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAVCFDNGRCQIMR 240
Query: 241 HENDQNPVLIDTGMYVVGIQWNHMGSVLAVAGFQKAAMQDKDVNIVQFYTPFGEHLGTLK 300
HENDQNPVLIDTGMYVVGIQWNHMGSVLAVAGFQKAAMQDKDVNIVQFYTPFGEHLGTLK
Sbjct: 241 HENDQNPVLIDTGMYVVGIQWNHMGSVLAVAGFQKAAMQDKDVNIVQFYTPFGEHLGTLK 300
Query: 301 VPGKEISALSWEGGGLKIALAVDSFIYFANIRPNYKWGYCSNTVVYAYTRPDRPEYCVVF 360
VPGKEISALSWEGGGLKIALAVDSFIYFANIRPNYKWGYCSNTVVYAYTRPDRPEYCVVF
Sbjct: 301 VPGKEISALSWEGGGLKIALAVDSFIYFANIRPNYKWGYCSNTVVYAYTRPDRPEYCVVF 360
Query: 361 WDTKNNEKYVKYVKGLISITTCGDFCILATKADENHPQ-----------FVLVLCNSIGT 409
WDTKNNEKYVKYVKGLISITTCGDFCILATKADENHPQ FVLVLCNSIGT
Sbjct: 361 WDTKNNEKYVKYVKGLISITTCGDFCILATKADENHPQEENEMETFGATFVLVLCNSIGT 420
Query: 410 PLDPKYIDIVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIY 469
PLDPKYIDIVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIY
Sbjct: 421 PLDPKYIDIVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIY 480
Query: 470 HVDDTPSGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQKY 529
HVDDTPSGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQKY
Sbjct: 481 HVDDTPSGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQKY 540
Query: 530 SLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMK 589
SLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMK
Sbjct: 541 SLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMK 600
Query: 590 WAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNK 649
WAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNK
Sbjct: 601 WAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNK 660
Query: 650 DYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFV 709
DYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFV
Sbjct: 661 DYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFV 720
Query: 710 RCKDYQGIKFVKRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDW 769
RCKDYQGIKFVKRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDW
Sbjct: 721 RCKDYQGIKFVKRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDW 780
Query: 770 FRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLE 829
FRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLE
Sbjct: 781 FRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLE 840
Query: 830 DYEGLENLAISLPENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNK 889
DYEGLENLAISLPENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNK
Sbjct: 841 DYEGLENLAISLPENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNK 900
Query: 890 AVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIADEEAKK 949
AVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIADEEAKK
Sbjct: 901 AVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIADEEAKK 960
Query: 950 GSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLSTTDRFT 1009
GSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLSTTDRFT
Sbjct: 961 GSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLSTTDRFT 1020
Query: 1010 DNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCACASRA 1069
DNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCACASRA
Sbjct: 1021 DNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCACASRA 1080
Query: 1070 FGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTC 1129
FGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTC
Sbjct: 1081 FGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTC 1140
Query: 1130 VATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG 1170
VATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
Sbjct: 1141 VATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG 1181
>gi|55953102 tubby like protein 4 isoform 2 [Homo sapiens]
Length = 678
Score = 144 bits (363), Expect = 5e-34
Identities = 104/364 (28%), Positives = 172/364 (47%), Gaps = 50/364 (13%)
Query: 5 LSKKISIPNNVKLQCVSWNK--EQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLS 62
LS K +P + K + V + E+G++A G G++ V T T R + P ++
Sbjct: 20 LSWKGRVPKSEKEKPVCRRRYYEEGWLATGNGRGVVGV----TFTSSHCRRDRSTPQRIN 75
Query: 63 MNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMS 122
N L GH+ V +V WNE YQKL T D +G I VW+ Y+G W E++N+R + V +
Sbjct: 76 FN--LRGHNSEVVLVRWNEPYQKLATCDADGGIFVWIQYEGRWSVELVNDRG-AQVSDFT 132
Query: 123 WNADGQKICIVYEDGAVIVGSVDGNRIWGKDLK-GIQLSHVTWSADSKVLLFGMANGEIH 181
W+ DG + I Y DG V+VGSV G R W ++ Q++ W+ D + +LFG A+G++
Sbjct: 133 WSHDGTQALISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVI 192
Query: 182 IYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYH-------------GTEGYVEPD----- 223
+ D G + + L + + G+ W + ++ Y P
Sbjct: 193 VMDCHGRMLAHVLLH------ESDGVLGMSWNYPIFLVEDSSESDTDSDDYAPPQDGPAA 246
Query: 224 --------CPCLAVCFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHMGSVLAVAGFQK 275
P L V F +G +M + +D +P +I +G+ V QW G +LAVAG ++
Sbjct: 247 YPIPVQNIKPLLTVSFTSGDISLMNNYDDLSPTVIRSGLKEVVAQWCTQGDLLAVAGMER 306
Query: 276 AAMQDKDVN-------IVQFYTPFGEHLGTL-KVPGKEISALSWEGGGLKIALAVDSFIY 327
+ N +V+FY GEH+ TL + + I ++ W ++ +A +Y
Sbjct: 307 QTQLGELPNGPLLKSAMVKFYNVRGEHIFTLDTLVQRPIISICWGHRDSRLLMASGPALY 366
Query: 328 FANI 331
+
Sbjct: 367 VVRV 370
>gi|55953100 tubby like protein 4 isoform 1 [Homo sapiens]
Length = 1543
Score = 144 bits (363), Expect = 5e-34
Identities = 104/364 (28%), Positives = 172/364 (47%), Gaps = 50/364 (13%)
Query: 5 LSKKISIPNNVKLQCVSWNK--EQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLS 62
LS K +P + K + V + E+G++A G G++ V T T R + P ++
Sbjct: 20 LSWKGRVPKSEKEKPVCRRRYYEEGWLATGNGRGVVGV----TFTSSHCRRDRSTPQRIN 75
Query: 63 MNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMS 122
N L GH+ V +V WNE YQKL T D +G I VW+ Y+G W E++N+R + V +
Sbjct: 76 FN--LRGHNSEVVLVRWNEPYQKLATCDADGGIFVWIQYEGRWSVELVNDRG-AQVSDFT 132
Query: 123 WNADGQKICIVYEDGAVIVGSVDGNRIWGKDLK-GIQLSHVTWSADSKVLLFGMANGEIH 181
W+ DG + I Y DG V+VGSV G R W ++ Q++ W+ D + +LFG A+G++
Sbjct: 133 WSHDGTQALISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVI 192
Query: 182 IYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYH-------------GTEGYVEPD----- 223
+ D G + + L + + G+ W + ++ Y P
Sbjct: 193 VMDCHGRMLAHVLLH------ESDGVLGMSWNYPIFLVEDSSESDTDSDDYAPPQDGPAA 246
Query: 224 --------CPCLAVCFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHMGSVLAVAGFQK 275
P L V F +G +M + +D +P +I +G+ V QW G +LAVAG ++
Sbjct: 247 YPIPVQNIKPLLTVSFTSGDISLMNNYDDLSPTVIRSGLKEVVAQWCTQGDLLAVAGMER 306
Query: 276 AAMQDKDVN-------IVQFYTPFGEHLGTL-KVPGKEISALSWEGGGLKIALAVDSFIY 327
+ N +V+FY GEH+ TL + + I ++ W ++ +A +Y
Sbjct: 307 QTQLGELPNGPLLKSAMVKFYNVRGEHIFTLDTLVQRPIISICWGHRDSRLLMASGPALY 366
Query: 328 FANI 331
+
Sbjct: 367 VVRV 370
>gi|16554625 WD repeat domain 10 isoform 4 [Homo sapiens]
Length = 1131
Score = 64.3 bits (155), Expect = 6e-10
Identities = 90/446 (20%), Positives = 181/446 (40%), Gaps = 37/446 (8%)
Query: 506 LIVGRESGTIQRYSLPNVGLIQKYSLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARV 565
L+VG ++G I + + N+ I L ++ + +LA++D + +D+D +
Sbjct: 377 LLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTK- 435
Query: 566 TDSTGQQVVGELLKLERRDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYIC 625
ELL + + + W D+ + + + P + G++
Sbjct: 436 ----------ELL-FQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVV 484
Query: 626 NFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHP 685
+ +I + + I E P + + R L I +G+ D
Sbjct: 485 GYNGSKIFCLHVFSI-SAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTD--------- 534
Query: 686 RLWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFV------KRLGKLLSESMKQAEVVGY 739
WR LA AL+ LD TA++AF+R +D + ++ + K+ G+ + + A+V Y
Sbjct: 535 --WRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIEERKKRGE-TNNDLFLADVFSY 591
Query: 740 FGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYF 799
G+F EA + Y +LA+ + L + L GSGD ++ + A D+
Sbjct: 592 QGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFL--GSGDPKETKMLITKQA--DWA 647
Query: 800 ADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPE-NHKLLPEIAQMFVRV 858
+ ++ AV+ Y+ + E + L ++A L + + L A ++
Sbjct: 648 RNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKL 707
Query: 859 GMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNK 918
A +LK K+ V V +W++A L + H + + YA L E ++
Sbjct: 708 DSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALGEKHPEFK-DDIYMPYAQWLAENDR 766
Query: 919 TLDAIELYRKANYFFDAAKLMFKIAD 944
+A + + KA +A +++ ++ +
Sbjct: 767 FEEAQKAFHKAGRQREAVQVLEQLTN 792
>gi|16554621 WD repeat domain 10 isoform 1 [Homo sapiens]
Length = 1292
Score = 64.3 bits (155), Expect = 6e-10
Identities = 90/446 (20%), Positives = 181/446 (40%), Gaps = 37/446 (8%)
Query: 506 LIVGRESGTIQRYSLPNVGLIQKYSLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARV 565
L+VG ++G I + + N+ I L ++ + +LA++D + +D+D +
Sbjct: 539 LLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTK- 597
Query: 566 TDSTGQQVVGELLKLERRDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYIC 625
ELL + + + W D+ + + + P + G++
Sbjct: 598 ----------ELL-FQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVV 646
Query: 626 NFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHP 685
+ +I + + I E P + + R L I +G+ D
Sbjct: 647 GYNGSKIFCLHVFSI-SAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTD--------- 696
Query: 686 RLWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFV------KRLGKLLSESMKQAEVVGY 739
WR LA AL+ LD TA++AF+R +D + ++ + K+ G+ + + A+V Y
Sbjct: 697 --WRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIEERKKQGE-TNNDLFLADVFSY 753
Query: 740 FGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYF 799
G+F EA + Y +LA+ + L + L GSGD ++ + A D+
Sbjct: 754 QGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFL--GSGDPKETKMLITKQA--DWA 809
Query: 800 ADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPE-NHKLLPEIAQMFVRV 858
+ ++ AV+ Y+ + E + L ++A L + + L A ++
Sbjct: 810 RNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKL 869
Query: 859 GMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNK 918
A +LK K+ V V +W++A L + H + + YA L E ++
Sbjct: 870 DSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALGEKHPEFK-DDIYMPYAQWLAENDR 928
Query: 919 TLDAIELYRKANYFFDAAKLMFKIAD 944
+A + + KA +A +++ ++ +
Sbjct: 929 FEEAQKAFHKAGRQREAVQVLEQLTN 954
>gi|16554619 WD repeat domain 10 isoform 3 [Homo sapiens]
Length = 1182
Score = 64.3 bits (155), Expect = 6e-10
Identities = 90/446 (20%), Positives = 181/446 (40%), Gaps = 37/446 (8%)
Query: 506 LIVGRESGTIQRYSLPNVGLIQKYSLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARV 565
L+VG ++G I + + N+ I L ++ + +LA++D + +D+D +
Sbjct: 429 LLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTK- 487
Query: 566 TDSTGQQVVGELLKLERRDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYIC 625
ELL + + + W D+ + + + P + G++
Sbjct: 488 ----------ELL-FQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVV 536
Query: 626 NFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHP 685
+ +I + + I E P + + R L I +G+ D
Sbjct: 537 GYNGSKIFCLHVFSI-SAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTD--------- 586
Query: 686 RLWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFV------KRLGKLLSESMKQAEVVGY 739
WR LA AL+ LD TA++AF+R +D + ++ + K+ G+ + + A+V Y
Sbjct: 587 --WRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIEERKKRGE-TNNDLFLADVFSY 643
Query: 740 FGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYF 799
G+F EA + Y +LA+ + L + L GSGD ++ + A D+
Sbjct: 644 QGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFL--GSGDPKETKMLITKQA--DWA 699
Query: 800 ADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPE-NHKLLPEIAQMFVRV 858
+ ++ AV+ Y+ + E + L ++A L + + L A ++
Sbjct: 700 RNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKL 759
Query: 859 GMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNK 918
A +LK K+ V V +W++A L + H + + YA L E ++
Sbjct: 760 DSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALGEKHPEFK-DDIYMPYAQWLAENDR 818
Query: 919 TLDAIELYRKANYFFDAAKLMFKIAD 944
+A + + KA +A +++ ++ +
Sbjct: 819 FEEAQKAFHKAGRQREAVQVLEQLTN 844
Score = 35.8 bits (81), Expect = 0.25
Identities = 27/143 (18%), Positives = 62/143 (43%), Gaps = 20/143 (13%)
Query: 59 SNLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVV 118
S+ ++ Q L+GH +V V + + ++ + + +I+W S +E ++ + +
Sbjct: 41 SDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWT----SKLEGILKYTHNDAI 96
Query: 119 RSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGI-------QLSHVTWSADSKVL 171
+ +S+N ++ S +W + K + ++ +W+ D + L
Sbjct: 97 QCVSYNPITHQLASC---------SSSDFGLWSPEQKSVSKHKSSSKIICCSWTNDGQYL 147
Query: 172 LFGMANGEIHIYDNQGNFMIKMK 194
GM NG I I + G +K++
Sbjct: 148 ALGMFNGIISIRNKNGEEKVKIE 170
>gi|16554623 WD repeat domain 10 isoform 2 [Homo sapiens]
Length = 1241
Score = 64.3 bits (155), Expect = 6e-10
Identities = 90/446 (20%), Positives = 181/446 (40%), Gaps = 37/446 (8%)
Query: 506 LIVGRESGTIQRYSLPNVGLIQKYSLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARV 565
L+VG ++G I + + N+ I L ++ + +LA++D + +D+D +
Sbjct: 488 LLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTK- 546
Query: 566 TDSTGQQVVGELLKLERRDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYIC 625
ELL + + + W D+ + + + P + G++
Sbjct: 547 ----------ELL-FQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVV 595
Query: 626 NFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHP 685
+ +I + + I E P + + R L I +G+ D
Sbjct: 596 GYNGSKIFCLHVFSI-SAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTD--------- 645
Query: 686 RLWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFV------KRLGKLLSESMKQAEVVGY 739
WR LA AL+ LD TA++AF+R +D + ++ + K+ G+ + + A+V Y
Sbjct: 646 --WRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIEERKKRGE-TNNDLFLADVFSY 702
Query: 740 FGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYF 799
G+F EA + Y +LA+ + L + L GSGD ++ + A D+
Sbjct: 703 QGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFL--GSGDPKETKMLITKQA--DWA 758
Query: 800 ADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPE-NHKLLPEIAQMFVRV 858
+ ++ AV+ Y+ + E + L ++A L + + L A ++
Sbjct: 759 RNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKL 818
Query: 859 GMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNK 918
A +LK K+ V V +W++A L + H + + YA L E ++
Sbjct: 819 DSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALGEKHPEFK-DDIYMPYAQWLAENDR 877
Query: 919 TLDAIELYRKANYFFDAAKLMFKIAD 944
+A + + KA +A +++ ++ +
Sbjct: 878 FEEAQKAFHKAGRQREAVQVLEQLTN 903
Score = 35.8 bits (81), Expect = 0.25
Identities = 27/143 (18%), Positives = 62/143 (43%), Gaps = 20/143 (13%)
Query: 59 SNLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVV 118
S+ ++ Q L+GH +V V + + ++ + + +I+W S +E ++ + +
Sbjct: 41 SDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWT----SKLEGILKYTHNDAI 96
Query: 119 RSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGI-------QLSHVTWSADSKVL 171
+ +S+N ++ S +W + K + ++ +W+ D + L
Sbjct: 97 QCVSYNPITHQLASC---------SSSDFGLWSPEQKSVSKHKSSSKIICCSWTNDGQYL 147
Query: 172 LFGMANGEIHIYDNQGNFMIKMK 194
GM NG I I + G +K++
Sbjct: 148 ALGMFNGIISIRNKNGEEKVKIE 170
>gi|46409657 WD repeat domain 56 [Homo sapiens]
Length = 777
Score = 46.6 bits (109), Expect = 1e-04
Identities = 25/89 (28%), Positives = 45/89 (50%)
Query: 687 LWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFVKRLGKLLSESMKQAEVVGYFGRFEEA 746
+W LA A+ D+ TAE A+ + ++++ + L S+ K A ++ + G +EA
Sbjct: 616 MWACLAAMAVANRDMTTAEIAYAAIGEIDKVQYINSIKNLPSKESKMAHILLFSGNIQEA 675
Query: 747 ERTYLEMDRRDLAIGLRLKLGDWFRVLQL 775
E L+ AI + + L +W R L+L
Sbjct: 676 EIVLLQAGLVYQAIQININLYNWERALEL 704
Score = 35.4 bits (80), Expect = 0.32
Identities = 31/128 (24%), Positives = 62/128 (48%), Gaps = 9/128 (7%)
Query: 63 MNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMS 122
+ +++E H G+V WN + L T E+G I +W K + + + + V S++
Sbjct: 98 VEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWS--KTGMLRSTLAQQG-TPVYSVA 154
Query: 123 WNADGQKICIVYEDG-AVIVGSVDGNR--IWGKDLKGIQLSHVTWSADSKVLLFGMANGE 179
W D +K ++Y G +I+ + N + K GI L V W++ + ++L + +
Sbjct: 155 WGPDSEK--VLYTAGKQLIIKPLQPNAKVLQWKAHDGIILK-VDWNSVNDLILSAGEDCK 211
Query: 180 IHIYDNQG 187
++D+ G
Sbjct: 212 YKVWDSYG 219
>gi|21536485 HIR histone cell cycle regulation defective homolog A
[Homo sapiens]
Length = 1017
Score = 46.2 bits (108), Expect = 2e-04
Identities = 31/129 (24%), Positives = 56/129 (43%), Gaps = 5/129 (3%)
Query: 17 LQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRG----LAAPSNLSMNQTLEGHSG 72
+ CV W+ ++A GG+D L+ V K T + + G LA L HSG
Sbjct: 73 VNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSG 132
Query: 73 SVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMSWNADGQKICI 132
V V W+ L + + +++W K I + + +V+ ++W+ G+ I
Sbjct: 133 DVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRG-HSGLVKGLTWDPVGKYIAS 191
Query: 133 VYEDGAVIV 141
+D ++ V
Sbjct: 192 QADDRSLKV 200
>gi|46358428 selective LIM binding factor homolog [Homo sapiens]
Length = 1749
Score = 45.8 bits (107), Expect = 2e-04
Identities = 52/264 (19%), Positives = 104/264 (39%), Gaps = 31/264 (11%)
Query: 687 LWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFVKRLGKLLSESMKQ------------A 734
+W+ L++ AL+ L+ AE+ F +F+ ++ + ++ A
Sbjct: 627 MWKTLSKLALEARQLHIAERCFSALGQVAKARFLHETNEIADQVSREYGGEGTDFYQVRA 686
Query: 735 EVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLE----- 789
+ ++ AE +LE + + A+G+ +L W + + + A + L
Sbjct: 687 RLAMLEKNYKLAEMIFLEQNAVEEAMGMYQELHRWDECIAVAEAKGHPALEKLRRSYYQW 746
Query: 790 ----QANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPENH 845
Q G+ + L A+ Y++ + A E+ L N
Sbjct: 747 LMDTQQEERAGELQESQGDGLAAISLYLKAGLPAKAARLVLTREE----------LLANT 796
Query: 846 KLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSL 905
+L+ I ++ + E+A F K P+ A++ N + KAVELA+ E+ L
Sbjct: 797 ELVEHITAALIKGELYERAGDLFEKIHNPQKALECYRKGNAFMKAVELARLAFPVEVVKL 856
Query: 906 LARYASHLLEKNKTLDAIELYRKA 929
+ HL+++ + AI Y +A
Sbjct: 857 EEAWGDHLVQQKQLDAAINHYIEA 880
Score = 45.1 bits (105), Expect = 4e-04
Identities = 66/253 (26%), Positives = 95/253 (37%), Gaps = 33/253 (13%)
Query: 741 GRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKT-GSGDADDSLLEQANNAIGDYF 799
GR +EAE YLE + + G W ++ +T G +A + ++G
Sbjct: 1043 GRLQEAEYHYLEAQEWKATVNMYRASGLWEEAYRVARTQGGANAHKHVAYLWAKSLGGEA 1102
Query: 800 ADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAIS--LPENHKLLPEIAQMFVR 857
A R LN + ++ C + E L LA+ PE H + A
Sbjct: 1103 AVRL--LNKLGL-LEAAVDHAADNCSF--EFAFELSRLALKHKTPEVHL---KYAMFLED 1154
Query: 858 VGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKN 917
G E+A F++ +PK AV VH W A +A+ H + +L A LE+
Sbjct: 1155 EGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVGQARGALEEK 1214
Query: 918 KTLDAIELYRKA-------NYFFDAAKLMFKIADEEAKKGSKPLRVKKLYV---LSALLI 967
A L +A NY+ +EA S LR+ K YV L AL
Sbjct: 1215 DFQKAEGLLLRAQRPGLALNYY------------KEAGLWSDALRICKDYVPSQLEALQE 1262
Query: 968 EQYHEQMKNAQRG 980
E E K RG
Sbjct: 1263 EYEREATKKGARG 1275
Score = 40.4 bits (93), Expect = 0.010
Identities = 18/51 (35%), Positives = 29/51 (56%)
Query: 876 AAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELY 926
AA+D V QW+K +E A + K + +A YA+HL+ + + A+ LY
Sbjct: 1416 AALDLYVEQGQWDKCIETATKQNYKILHKYVALYATHLIREGSSAQALALY 1466
Score = 38.5 bits (88), Expect = 0.038
Identities = 37/168 (22%), Positives = 65/168 (38%), Gaps = 16/168 (9%)
Query: 743 FEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQ-ANNAIGDYFAD 801
F++AE L R LA+ + G W L++ K ++L E+ A
Sbjct: 1216 FQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPSQLEALQEEYEREATKKGARG 1275
Query: 802 RQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAIS------------LP--ENHKL 847
+ ++ +++ Q R +CY + D G LA LP N ++
Sbjct: 1276 VEGFVEQARHWEQAGEYSRAVDCYLKVRD-SGNSGLAEKCWMKAAELSIKFLPPQRNMEV 1334
Query: 848 LPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAK 895
+ + + +G A +L K A+D + +WNKA +AK
Sbjct: 1335 VLAVGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRVAK 1382
Score = 35.0 bits (79), Expect = 0.42
Identities = 38/168 (22%), Positives = 73/168 (43%), Gaps = 23/168 (13%)
Query: 817 NQERLAECYYMLEDY-EGLENLAISLP-ENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQP 874
N ++ ECY + + +E ++ P E KL V+ + A+ +++
Sbjct: 824 NPQKALECYRKGNAFMKAVELARLAFPVEVVKLEEAWGDHLVQQKQLDAAINHYIEARCS 883
Query: 875 KAAVDTCVHLNQWNKAV---ELAKNHSMKEIGSLLARYASHLLE----------KNKTLD 921
A++ + QW KA+ +L ++ + L+A++ + L E ++T D
Sbjct: 884 IKAIEAALGARQWKKAIYILDLQDRNTASKYYPLVAQHYASLQEYEIAEELYTKGDRTKD 943
Query: 922 AIELYRKANYFFDAAKLMFKIADEEAKKGSKPLRVKKLYVLSALLIEQ 969
AI++Y +A + A KL A K +P V LY+ A +E+
Sbjct: 944 AIDMYTQAGRWEQAHKL--------AMKCMRPEDVSVLYITQAQEMEK 983
Score = 32.3 bits (72), Expect = 2.7
Identities = 29/136 (21%), Positives = 57/136 (41%), Gaps = 3/136 (2%)
Query: 794 AIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPEN--HKLLPEI 851
A GD+ +++ A+ +Y++ R + E ++ + N K P +
Sbjct: 859 AWGDHLVQQKQLDAAINHYIEARCSIKAIEAALGARQWKKAIYILDLQDRNTASKYYPLV 918
Query: 852 AQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELA-KNHSMKEIGSLLARYA 910
AQ + + E A + K + K A+D +W +A +LA K +++ L A
Sbjct: 919 AQHYASLQEYEIAEELYTKGDRTKDAIDMYTQAGRWEQAHKLAMKCMRPEDVSVLYITQA 978
Query: 911 SHLLEKNKTLDAIELY 926
+ ++ K +A LY
Sbjct: 979 QEMEKQGKYREAERLY 994
>gi|4885105 chromatin assembly factor 1 subunit B [Homo sapiens]
Length = 559
Score = 44.3 bits (103), Expect = 7e-04
Identities = 29/127 (22%), Positives = 58/127 (45%), Gaps = 8/127 (6%)
Query: 29 IACGGEDGLLKVLKLETQTDDAKL------RGLAAPSNLSMNQTLEGHSGSVQVVTWNEQ 82
+A GG+D ++ + K+ + ++ N ++ +TL GH V + W
Sbjct: 81 LASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATD 140
Query: 83 YQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVG 142
+ ++ + I+W + KG I I N +KS V+ ++W+ GQ + + D + V
Sbjct: 141 GNLMASASVDNTAIIWDVSKGQKIS--IFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVY 198
Query: 143 SVDGNRI 149
S+ R+
Sbjct: 199 SIQKKRV 205
>gi|14150171 THO complex 3 [Homo sapiens]
Length = 351
Score = 42.7 bits (99), Expect = 0.002
Identities = 35/173 (20%), Positives = 71/173 (41%), Gaps = 17/173 (9%)
Query: 11 IPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMNQTLEGH 70
+ ++ K+ V+W+ + +A G D V LE L GH
Sbjct: 52 LAHSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKD-------------RLVKENNYRGH 98
Query: 71 SGSVQVVTWNEQYQKL-TTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMSWNADGQK 129
SV + W+ L T+ + I +W + I +N + +++ ++ W+ DGQ
Sbjct: 99 GDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIAT-VNTKGENI--NICWSPDGQT 155
Query: 130 ICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEIHI 182
I + +D V +R ++ +++ ++W+ D+ + NG I+I
Sbjct: 156 IAVGNKDDVVTFIDAKTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINI 208
>gi|169403944 WD repeat domain 26 isoform b [Homo sapiens]
Length = 498
Score = 41.2 bits (95), Expect = 0.006
Identities = 29/126 (23%), Positives = 58/126 (46%), Gaps = 5/126 (3%)
Query: 61 LSMNQTLEGHSGSVQVVTW--NEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVV 118
L + +TLEGH+ V + W ++ Y D+ + +W + G +M + S+
Sbjct: 228 LKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLT 287
Query: 119 RSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANG 178
S++WN DG++ + G +DGN + +G+++ + +D K +L +
Sbjct: 288 -SVAWNPDGKRFVTGGQRGQFYQCDLDGNLL--DSWEGVRVQCLWCLSDGKTVLASDTHQ 344
Query: 179 EIHIYD 184
I Y+
Sbjct: 345 RIRGYN 350
Score = 31.2 bits (69), Expect = 6.0
Identities = 38/203 (18%), Positives = 76/203 (37%), Gaps = 36/203 (17%)
Query: 65 QTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSV--VRSMS 122
Q L H V ++ KL T ++ +I+W + + + +++ V ++
Sbjct: 186 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIA 245
Query: 123 WNADGQKICIVYEDGAVIVGSVDGNRIW------GKDLKGIQLSH------VTWSADSKV 170
W+ D + V G D + +W G+ + SH V W+ D K
Sbjct: 246 WSPDDNYL--------VACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKR 297
Query: 171 LLFGMANGEIHIYDNQGNFMIK---MKLSCLVNVTGAISIAGIHWYHGTEGY-------- 219
+ G G+ + D GN + +++ CL ++ ++ + GY
Sbjct: 298 FVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDR 357
Query: 220 --VEPDCPCLAVCFD-NGRCQIM 239
V+ D P ++ NGR ++
Sbjct: 358 NIVQEDHPIMSFTISKNGRLALL 380
>gi|55743153 WD repeat domain 26 isoform a [Homo sapiens]
Length = 514
Score = 41.2 bits (95), Expect = 0.006
Identities = 29/126 (23%), Positives = 58/126 (46%), Gaps = 5/126 (3%)
Query: 61 LSMNQTLEGHSGSVQVVTW--NEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVV 118
L + +TLEGH+ V + W ++ Y D+ + +W + G +M + S+
Sbjct: 244 LKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLT 303
Query: 119 RSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANG 178
S++WN DG++ + G +DGN + +G+++ + +D K +L +
Sbjct: 304 -SVAWNPDGKRFVTGGQRGQFYQCDLDGNLL--DSWEGVRVQCLWCLSDGKTVLASDTHQ 360
Query: 179 EIHIYD 184
I Y+
Sbjct: 361 RIRGYN 366
Score = 31.2 bits (69), Expect = 6.0
Identities = 38/203 (18%), Positives = 76/203 (37%), Gaps = 36/203 (17%)
Query: 65 QTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSV--VRSMS 122
Q L H V ++ KL T ++ +I+W + + + +++ V ++
Sbjct: 202 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIA 261
Query: 123 WNADGQKICIVYEDGAVIVGSVDGNRIW------GKDLKGIQLSH------VTWSADSKV 170
W+ D + V G D + +W G+ + SH V W+ D K
Sbjct: 262 WSPDDNYL--------VACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKR 313
Query: 171 LLFGMANGEIHIYDNQGNFMIK---MKLSCLVNVTGAISIAGIHWYHGTEGY-------- 219
+ G G+ + D GN + +++ CL ++ ++ + GY
Sbjct: 314 FVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDR 373
Query: 220 --VEPDCPCLAVCFD-NGRCQIM 239
V+ D P ++ NGR ++
Sbjct: 374 NIVQEDHPIMSFTISKNGRLALL 396
>gi|5902134 coronin, actin binding protein, 1A [Homo sapiens]
Length = 461
Score = 40.8 bits (94), Expect = 0.008
Identities = 32/128 (25%), Positives = 62/128 (48%), Gaps = 7/128 (5%)
Query: 66 TLEGHSGSVQVVTWNEQYQK-LTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMSWN 124
TLEGH+ V +V W+ Q L ++ + +I+VW + G+ + + + + S+ W+
Sbjct: 126 TLEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAMLTLGPEVHPDTIYSVDWS 185
Query: 125 ADGQKICIVYEDGAV-IVGSVDGNRIWGKDL--KGIQLSHVTWSADSKVLLFG---MANG 178
DG IC D V I+ G + KD +G + + ++ K+L G M+
Sbjct: 186 RDGGLICTSCRDKRVRIIEPRKGTVVAEKDRPHEGTRPVRAVFVSEGKILTTGFSRMSER 245
Query: 179 EIHIYDNQ 186
++ ++D +
Sbjct: 246 QVALWDTK 253
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 40.0 bits (92), Expect = 0.013
Identities = 33/138 (23%), Positives = 67/138 (48%), Gaps = 23/138 (16%)
Query: 55 LAAPSNLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRN 114
+A+P+++++ + L GH +V VV ++++Y + ++ + I VW N
Sbjct: 374 MASPTDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKVW------------NTST 419
Query: 115 KSVVRSMSWNADGQKICIVYEDGAVIVGSVDGN-RIWG-------KDLKGIQLSHVTWSA 166
VR+++ + G C+ Y D V+ GS D R+W + L+G +
Sbjct: 420 CEFVRTLNGHKRG-IACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF 478
Query: 167 DSKVLLFGMANGEIHIYD 184
D+K ++ G +G+I ++D
Sbjct: 479 DNKRIVSGAYDGKIKVWD 496
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 40.0 bits (92), Expect = 0.013
Identities = 33/138 (23%), Positives = 67/138 (48%), Gaps = 23/138 (16%)
Query: 55 LAAPSNLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRN 114
+A+P+++++ + L GH +V VV ++++Y + ++ + I VW N
Sbjct: 410 MASPTDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKVW------------NTST 455
Query: 115 KSVVRSMSWNADGQKICIVYEDGAVIVGSVDGN-RIWG-------KDLKGIQLSHVTWSA 166
VR+++ + G C+ Y D V+ GS D R+W + L+G +
Sbjct: 456 CEFVRTLNGHKRG-IACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF 514
Query: 167 DSKVLLFGMANGEIHIYD 184
D+K ++ G +G+I ++D
Sbjct: 515 DNKRIVSGAYDGKIKVWD 532
>gi|7656991 coronin, actin binding protein, 1C isoform 1 [Homo
sapiens]
Length = 474
Score = 39.7 bits (91), Expect = 0.017
Identities = 25/78 (32%), Positives = 42/78 (53%), Gaps = 6/78 (7%)
Query: 67 LEGHSGSVQVVTWNEQYQK-LTTSDENGLIIVWMLYKGSWIEEMIN--NRNKSVVRSMSW 123
LEGHS V +V W+ + L ++ + II+W + G E +IN + + ++ ++SW
Sbjct: 126 LEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTG---EALINLDDMHSDMIYNVSW 182
Query: 124 NADGQKICIVYEDGAVIV 141
N +G IC +D V V
Sbjct: 183 NRNGSLICTASKDKKVRV 200
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 38.9 bits (89), Expect = 0.029
Identities = 34/185 (18%), Positives = 77/185 (41%), Gaps = 17/185 (9%)
Query: 5 LSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMN 64
LS+ I ++C ++ + ++ G DG ++V T L+ A + + M+
Sbjct: 205 LSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMD 264
Query: 65 QTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMSWN 124
+V + ++ + L T ++G I VW + G + +K V +S++
Sbjct: 265 D-------AVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVT-CLSFS 316
Query: 125 ADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQ-----LSHVTWSADSKVLLFGMANGE 179
D +I D + + + GK LK + ++ T++ D ++ ++G
Sbjct: 317 KDSSQILSASFDQTIRIHGLKS----GKTLKEFRGHSSFVNEATFTQDGHYIISASSDGT 372
Query: 180 IHIYD 184
+ I++
Sbjct: 373 VKIWN 377
Score = 33.1 bits (74), Expect = 1.6
Identities = 37/189 (19%), Positives = 78/189 (41%), Gaps = 28/189 (14%)
Query: 19 CVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMNQTLEGHSGSVQVVT 78
C+ ++++ +A G +DG +KV K++ S + + HS V ++
Sbjct: 269 CMCFSRDTEMLATGAQDGKIKVWKIQ--------------SGQCLRRFERAHSKGVTCLS 314
Query: 79 WNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMSWNADGQKICIVYEDGA 138
+++ ++ ++ + I + L G ++E + S V ++ DG I DG
Sbjct: 315 FSKDSSQILSASFDQTIRIHGLKSGKTLKEF--RGHSSFVNEATFTQDGHYIISASSDGT 372
Query: 139 VIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEIHIYDNQGNFMI--KMKLS 196
V +IW ++K + S+ S S N I + N +F++ +
Sbjct: 373 V--------KIW--NMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTV 422
Query: 197 CLVNVTGAI 205
++N+ G I
Sbjct: 423 VIMNMQGQI 431
>gi|14149696 SEC31 homolog B [Homo sapiens]
Length = 1179
Score = 38.9 bits (89), Expect = 0.029
Identities = 37/149 (24%), Positives = 74/149 (49%), Gaps = 13/149 (8%)
Query: 59 SNLSMNQTLEGHSGS----VQVVTWNEQYQK-LTTSDENGLIIVWMLYKGSWIEEMINNR 113
+NL++ TL S ++ ++WN Q Q L+++ +G +VW L K I ++ ++
Sbjct: 152 NNLNVPMTLGSKSQQPPEDIKALSWNRQAQHILSSAHPSGKAVVWDLRKNEPIIKVSDHS 211
Query: 114 NKSVVRSMSWNAD-GQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQ-----LSHVTWS-A 166
N+ ++W+ D ++ + ED + V + R LK ++ + V+WS A
Sbjct: 212 NRMHCSGLAWHPDIATQLVLCSEDDRLPVIQLWDLRFASSPLKVLESHSRGILSVSWSQA 271
Query: 167 DSKVLLFGMANGEIHIYDNQGNFMIKMKL 195
D+++LL + +I + N G+ + KL
Sbjct: 272 DAELLLTSAKDSQI-LCRNLGSSEVVYKL 299
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 38.9 bits (89), Expect = 0.029
Identities = 25/97 (25%), Positives = 49/97 (50%), Gaps = 3/97 (3%)
Query: 60 NLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVR 119
N ++ TL GH+ +V V ++ + L +S + LII+W Y G + E+ + N +
Sbjct: 30 NYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKY-EKTLYGHNLE-IS 87
Query: 120 SMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKG 156
++W++D ++ +D + + V + K LKG
Sbjct: 88 DVAWSSDSSRLVSASDDKTLKLWDVRSGKCL-KTLKG 123
Score = 31.6 bits (70), Expect = 4.6
Identities = 34/183 (18%), Positives = 75/183 (40%), Gaps = 37/183 (20%)
Query: 13 NNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMNQTLEGHSG 72
+N+++ V+W+ + + +D LK+ + + +TL+GHS
Sbjct: 82 HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSG---------------KCLKTLKGHSN 126
Query: 73 SVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMSWNADGQKICI 132
V +N + + + + +W + G ++ + + + V ++ +N G
Sbjct: 127 YVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL--SAHSDPVSAVHFNCSG----- 179
Query: 133 VYEDGAVIVGSVDG-NRIW----GKDLKGI------QLSHVTWSADSKVLLFGMANGEIH 181
++ GS DG RIW G+ LK + +S V +S + K +L + +
Sbjct: 180 ----SLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLK 235
Query: 182 IYD 184
++D
Sbjct: 236 LWD 238
>gi|41281447 intraflagellar transport 140 [Homo sapiens]
Length = 1462
Score = 38.5 bits (88), Expect = 0.038
Identities = 21/85 (24%), Positives = 39/85 (45%)
Query: 846 KLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSL 905
+L +A + ++GM E A + KC + +W +A+++A++H + S
Sbjct: 844 ELEARVAVLATQLGMLEDAEQLYRKCKRHDLLNKFYQAAGRWQEALQVAEHHDRVHLRST 903
Query: 906 LARYASHLLEKNKTLDAIELYRKAN 930
RYA HL A+ Y K++
Sbjct: 904 YHRYAGHLEASADCSRALSYYEKSD 928
Score = 32.7 bits (73), Expect = 2.1
Identities = 58/240 (24%), Positives = 89/240 (37%), Gaps = 33/240 (13%)
Query: 697 QKLDLYTAEQAFVR----CKDYQGIKFVKRLGKLLSESMKQAEVVGYFGRFEEAERTYLE 752
Q + YT QAF CK+ G+ LLS E Y+ E ++
Sbjct: 1028 QAVHFYTRAQAFKNAIRLCKE-NGLDDQLMNLALLSSPEDMIEAARYY------EEKGVQ 1080
Query: 753 MDRRDLAIGLRLKLGDWFRVLQL---------LKTGSGDADDSLLEQANNAIGDYFADRQ 803
MDR A+ L K G + + L+L L+ + D D++ D+F +
Sbjct: 1081 MDR---AVMLYHKAGHFSKALELAFATQQFVALQLIAEDLDETSDPALLARCSDFFIEHS 1137
Query: 804 KWLNAVQYYVQGRN-QERLAECY--YMLEDYEGLENLAIS-----LPENHK--LLPEIAQ 853
++ AV+ + R QE L C M E E + ++ LPE + LL +IA
Sbjct: 1138 QYERAVELLLAARKYQEALQLCLGQNMSITEEMAEKMTVAKDSSDLPEESRRELLEQIAD 1197
Query: 854 MFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHL 913
+R G A + + A+ + K A KEI + A Y L
Sbjct: 1198 CCMRQGSYHLATKKYTQAGNKLKAMRALLKSGDTEKITFFASVSRQKEIYIMAANYLQSL 1257
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 38.1 bits (87), Expect = 0.049
Identities = 28/127 (22%), Positives = 60/127 (47%), Gaps = 5/127 (3%)
Query: 60 NLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVR 119
N ++ TL GH+ +V V ++ + L +S + LI +W Y G + E + +K +
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKF--EKTISGHKLGIS 91
Query: 120 SMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQ--LSHVTWSADSKVLLFGMAN 177
++W++D + +D + + V + K LKG + ++ S +++ G +
Sbjct: 92 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCL-KTLKGHSNYVFCCNFNPQSNLIVSGSFD 150
Query: 178 GEIHIYD 184
+ I+D
Sbjct: 151 ESVRIWD 157
Score = 32.7 bits (73), Expect = 2.1
Identities = 40/194 (20%), Positives = 74/194 (38%), Gaps = 42/194 (21%)
Query: 20 VSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMNQTLEGHSGSVQVVTW 79
V+W+ + + +D LK+ + S+ +TL+GHS V +
Sbjct: 93 VAWSSDSNLLVSASDDKTLKIWDV---------------SSGKCLKTLKGHSNYVFCCNF 137
Query: 80 NEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMSWNADGQKICIVYEDGAV 139
N Q + + + + +W + G ++ + + V ++ +N DG I DG
Sbjct: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTL--PAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 140 IVGSVDGNRIW----GKDLKGI------QLSHVTWSADSKVLLFGMANGEIHIYDNQGNF 189
RIW G+ LK + +S V +S + K +L + + ++D
Sbjct: 196 --------RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS--- 244
Query: 190 MIKMKLSCLVNVTG 203
K CL TG
Sbjct: 245 ----KGKCLKTYTG 254
Score = 31.6 bits (70), Expect = 4.6
Identities = 21/99 (21%), Positives = 40/99 (40%), Gaps = 15/99 (15%)
Query: 19 CVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMNQTLEGHSGSVQVVT 78
C ++N + I G D +++ ++T +TL HS V V
Sbjct: 134 CCNFNPQSNLIVSGSFDESVRIWDVKTG---------------KCLKTLPAHSDPVSAVH 178
Query: 79 WNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSV 117
+N + +S +GL +W G ++ +I++ N V
Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 38.1 bits (87), Expect = 0.049
Identities = 28/127 (22%), Positives = 60/127 (47%), Gaps = 5/127 (3%)
Query: 60 NLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVR 119
N ++ TL GH+ +V V ++ + L +S + LI +W Y G + E + +K +
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKF--EKTISGHKLGIS 91
Query: 120 SMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQ--LSHVTWSADSKVLLFGMAN 177
++W++D + +D + + V + K LKG + ++ S +++ G +
Sbjct: 92 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCL-KTLKGHSNYVFCCNFNPQSNLIVSGSFD 150
Query: 178 GEIHIYD 184
+ I+D
Sbjct: 151 ESVRIWD 157
Score = 32.7 bits (73), Expect = 2.1
Identities = 40/194 (20%), Positives = 74/194 (38%), Gaps = 42/194 (21%)
Query: 20 VSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMNQTLEGHSGSVQVVTW 79
V+W+ + + +D LK+ + S+ +TL+GHS V +
Sbjct: 93 VAWSSDSNLLVSASDDKTLKIWDV---------------SSGKCLKTLKGHSNYVFCCNF 137
Query: 80 NEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMSWNADGQKICIVYEDGAV 139
N Q + + + + +W + G ++ + + V ++ +N DG I DG
Sbjct: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTL--PAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 140 IVGSVDGNRIW----GKDLKGI------QLSHVTWSADSKVLLFGMANGEIHIYDNQGNF 189
RIW G+ LK + +S V +S + K +L + + ++D
Sbjct: 196 --------RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS--- 244
Query: 190 MIKMKLSCLVNVTG 203
K CL TG
Sbjct: 245 ----KGKCLKTYTG 254
Score = 31.6 bits (70), Expect = 4.6
Identities = 21/99 (21%), Positives = 40/99 (40%), Gaps = 15/99 (15%)
Query: 19 CVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMNQTLEGHSGSVQVVT 78
C ++N + I G D +++ ++T +TL HS V V
Sbjct: 134 CCNFNPQSNLIVSGSFDESVRIWDVKTG---------------KCLKTLPAHSDPVSAVH 178
Query: 79 WNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSV 117
+N + +S +GL +W G ++ +I++ N V
Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217
>gi|109627650 coronin 6 [Homo sapiens]
Length = 472
Score = 38.1 bits (87), Expect = 0.049
Identities = 19/72 (26%), Positives = 41/72 (56%), Gaps = 2/72 (2%)
Query: 66 TLEGHSGSVQVVTWNEQYQK-LTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMSWN 124
TLEGHS V +++W+ + L ++ + +II+W + G + +++ + V+ S+ WN
Sbjct: 126 TLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGE-VLLSLDDMHPDVIHSVCWN 184
Query: 125 ADGQKICIVYED 136
++G + +D
Sbjct: 185 SNGSLLATTCKD 196
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 38.1 bits (87), Expect = 0.049
Identities = 41/170 (24%), Positives = 71/170 (41%), Gaps = 20/170 (11%)
Query: 20 VSW--NKEQGF--IACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMNQTLEGHSGSVQ 75
V+W NK++ + G D L+KV K + L + +LEGH V
Sbjct: 22 VAWGTNKKENSETVVTGSLDDLVKVWKWRDE-------------RLDLQWSLEGHQLGVV 68
Query: 76 VVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMSWNADGQKICIVYE 135
V + +S + I +W L G I+ + + +++++ D Q +
Sbjct: 69 SVDISHTLPIAASSSLDAHIRLWDLENGKQIKSI--DAGPVDAWTLAFSPDSQYLATGTH 126
Query: 136 DGAV-IVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEIHIYD 184
G V I G G + + D +G + + +S D K L G +G I+I+D
Sbjct: 127 VGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFD 176
Score = 31.6 bits (70), Expect = 4.6
Identities = 35/176 (19%), Positives = 74/176 (42%), Gaps = 38/176 (21%)
Query: 20 VSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMNQTLEGHSGSVQVVTW 79
++++ + ++A G DG++ + + T + TLEGH+ ++ +T+
Sbjct: 154 IAYSPDGKYLASGAIDGIINIFDIATG---------------KLLHTLEGHAMPIRSLTF 198
Query: 80 NEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRSMSWNADGQKICIVYEDGAV 139
+ Q L T+ ++G I ++ + + + + + S V ++++ D D +V
Sbjct: 199 SPDSQLLVTASDDGYIKIYDVQHANLAGTL--SGHASWVLNVAFCPDDTHFVSSSSDKSV 256
Query: 140 IVGSV-----------DGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEIHIYD 184
V V +++WG G SK++ G + EIHIYD
Sbjct: 257 KVWDVGTRTCVHTFFDHQDQVWGVKYNG---------NGSKIVSVG-DDQEIHIYD 302
>gi|16418439 WD repeat and FYVE domain containing 2 [Homo sapiens]
Length = 400
Score = 38.1 bits (87), Expect = 0.049
Identities = 29/131 (22%), Positives = 60/131 (45%), Gaps = 18/131 (13%)
Query: 20 VSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMNQTLEGHSGSVQVVTW 79
+ ++ E + G G + +LKLE + N ++ T GH+G V + W
Sbjct: 161 LQFDVETRHVFIGDHSGQVTILKLEQE-------------NCTLVTTFRGHTGGVTALCW 207
Query: 80 NEQYQKLTTSDENGLIIVWML--YKGSWIEEMINNRNKSVVRSMSWNADGQKICIVYEDG 137
+ + L + + +I+W + KG+ IE +N V+++S+ +++ DG
Sbjct: 208 DPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDR---VQALSYAQHTRQLISCGGDG 264
Query: 138 AVIVGSVDGNR 148
++V ++D R
Sbjct: 265 GIVVWNMDVER 275
>gi|32699064 WD repeat domain 53 [Homo sapiens]
Length = 358
Score = 37.7 bits (86), Expect = 0.065
Identities = 49/202 (24%), Positives = 84/202 (41%), Gaps = 35/202 (17%)
Query: 13 NNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMNQTLEGHSG 72
N ++ C+S N+ + +A + G +K+L LE N + ++L+ HS
Sbjct: 93 NEEEINCLSLNQTENLLASADDSGAIKILDLE---------------NKKVIRSLKRHSN 137
Query: 73 SVQVVTWNEQY-QKLTTSDENGLIIVWMLYKGS--WI--------EEMINNR------NK 115
V + Q Q L + + +++W L K WI EEM + N
Sbjct: 138 ICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNP 197
Query: 116 SVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGK-DLKG--IQLSHVTWSADSKVLL 172
++ S+S + G EDG V + V G + + KG +S V + +S +LL
Sbjct: 198 ALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLL 257
Query: 173 FGMANGEIHIYDNQGNFMIKMK 194
G +G+I ++D K K
Sbjct: 258 TGGNDGKITLWDANSEVEKKQK 279
>gi|65787364 coronin, actin binding protein, 1B [Homo sapiens]
Length = 489
Score = 37.7 bits (86), Expect = 0.065
Identities = 52/233 (22%), Positives = 100/233 (42%), Gaps = 37/233 (15%)
Query: 29 IACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMNQTLEGHSGSVQVVTWNEQYQK-LT 87
IA G ED + V ++ GL +P + LEGH+ V ++ W+ + L
Sbjct: 98 IASGSEDCTVMVWQIPEN-------GLTSPLTEPV-VVLEGHTKRVGIIAWHPTARNVLL 149
Query: 88 TSDENGLIIVWMLYKGSWIEEM--INNRNKSVVRSMSWNADGQKICIVYEDGAVIV---- 141
++ + ++++W + EE+ +++ + ++ ++SWN +G C +D +V +
Sbjct: 150 SAGCDNVVLIWNV---GTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPR 206
Query: 142 -GSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFG---MANGEIHIYDNQGNFMIKMKLSC 197
G++ R K +G + + AD KV G M+ ++ ++D + N M L
Sbjct: 207 RGTLVAER--EKAHEGARPMRAIFLADGKVFTTGFSRMSERQLALWDPE-NLEEPMALQE 263
Query: 198 LVNVTGAISIAGIHWYHGTEGYVEPDCPCLAVCFDNGRCQIMRHENDQNPVLI 250
L + GA+ + +PD + VC G I E + P I
Sbjct: 264 LDSSNGALL-----------PFYDPDTSVVYVC-GKGDSSIRYFEITEEPPYI 304
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,942,245
Number of Sequences: 37866
Number of extensions: 1849407
Number of successful extensions: 4754
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 93
Number of HSP's that attempted gapping in prelim test: 4388
Number of HSP's gapped (non-prelim): 375
length of query: 1170
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1057
effective length of database: 13,968,660
effective search space: 14764873620
effective search space used: 14764873620
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.