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Search of human proteins with 56118310
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56118310 nuclear casein kinase and cyclin-dependent kinase
substrate 1 [Homo sapiens]
(243 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56118310 nuclear casein kinase and cyclin-dependent kinase su... 489 e-138
gi|5453904 RAD51 associated protein 1 isoform b [Homo sapiens] 84 9e-17
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 72 6e-13
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 72 6e-13
gi|55956788 nucleolin [Homo sapiens] 70 2e-12
gi|195947391 RAD51 associated protein 1 isoform a [Homo sapiens] 69 4e-12
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 65 5e-11
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 65 7e-11
gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homo... 62 3e-10
gi|21396500 HIRA interacting protein 3 [Homo sapiens] 62 5e-10
gi|156104891 general transcription factor IIF, polypeptide 1, 74... 62 5e-10
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 62 6e-10
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 62 6e-10
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 61 1e-09
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 60 1e-09
gi|223941846 zinc finger protein 652 [Homo sapiens] 60 2e-09
gi|7662384 zinc finger protein 652 [Homo sapiens] 60 2e-09
gi|217330641 IWS1 homolog [Homo sapiens] 59 3e-09
gi|55741677 SET domain containing 1A [Homo sapiens] 59 4e-09
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 59 5e-09
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 59 5e-09
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 58 9e-09
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 58 9e-09
gi|4557509 cylicin 2 [Homo sapiens] 57 1e-08
gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo ... 57 1e-08
gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo s... 57 1e-08
gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo sa... 57 1e-08
gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 56 2e-08
gi|117553584 adaptor-related protein complex 3, delta 1 subunit ... 56 2e-08
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 56 2e-08
>gi|56118310 nuclear casein kinase and cyclin-dependent kinase
substrate 1 [Homo sapiens]
Length = 243
Score = 489 bits (1258), Expect = e-138
Identities = 243/243 (100%), Positives = 243/243 (100%)
Query: 1 MSRPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSED 60
MSRPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSED
Sbjct: 1 MSRPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSED 60
Query: 61 SEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEE 120
SEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEE
Sbjct: 61 SEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEE 120
Query: 121 DEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTP 180
DEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTP
Sbjct: 121 DEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTP 180
Query: 181 SPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGSEDEAPS 240
SPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGSEDEAPS
Sbjct: 181 SPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGSEDEAPS 240
Query: 241 GED 243
GED
Sbjct: 241 GED 243
>gi|5453904 RAD51 associated protein 1 isoform b [Homo sapiens]
Length = 335
Score = 84.3 bits (207), Expect = 9e-17
Identities = 84/305 (27%), Positives = 126/305 (41%), Gaps = 77/305 (25%)
Query: 1 MSRPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKN-------------- 46
M RPVR++K V+YSQF SD +D+D+ + P KK R++P+E K
Sbjct: 1 MVRPVRHKKPVNYSQFDHSD-SDDDFVSATVPLNKKSRTAPKELKQDKPKPNLNNLRKEE 59
Query: 47 --------KRRSGKNSQEDSEDSED------KDVKTKKDDSHSAEDSEDEK--------- 83
K+R + + D E K++ T + +++D EK
Sbjct: 60 IPVQEKTPKKRMALDDKLYQRDLEVALALSVKELPTVTTNVQNSQDKSIEKHGSSKIETM 119
Query: 84 ------------------------EDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEE 119
+D V+ +R+AASKAA++QR++L+E GS+ +
Sbjct: 120 NKSPHISNCSVASDYLDLDKITVEDDVGGVQGKRKAASKAAAQQRKILLE--GSDGDSAN 177
Query: 120 EDEAPFQE-KDSGSDEDFLMEDDDDSDYGSSKKK----NKKMVKKSKPERKEKKMPKPRL 174
+ E F +DS D DF +D+D D+ K K KK VK P K++K K +
Sbjct: 178 DTEPDFAPGEDSEDDSDFCESEDNDEDFSMRKSKVKEIKKKEVKVKSPVEKKEKKSKSKC 237
Query: 175 KATVT-----PSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKS 229
A VT P+ VK + + P S + T P E S KK PP
Sbjct: 238 NALVTSVDSAPAAVKSESQ-SLPKKVSLSSDTTRKPLE--IRSPSAESKKPKWVPPAASG 294
Query: 230 GDEGS 234
G S
Sbjct: 295 GSRSS 299
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 71.6 bits (174), Expect = 6e-13
Identities = 56/210 (26%), Positives = 99/210 (47%), Gaps = 19/210 (9%)
Query: 43 EAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASK 102
EA+ + + K S + E K+ + +K++ E+ E+E E K+ + + + K S
Sbjct: 500 EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSS 559
Query: 103 QREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKP 162
++E G +EE E E EA +E ++ ++ ++ S+ ++K++ K KP
Sbjct: 560 EKEE-----GEQEEGETEAEAEGEEAEAKEEKKV----EEKSEEVATKEELVADAKVEKP 610
Query: 163 ERKEKKMPKPRL----KATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEE------P 212
E+ + +PK + K+ V SPV+ KGK P + K K+P PK EE
Sbjct: 611 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVS 670
Query: 213 ESPPEKKTSTSPPPEKSGDEGSEDEAPSGE 242
+SP E+K + P + S+ E GE
Sbjct: 671 KSPVEEKAKSPVPKSPVEEAKSKAEVGKGE 700
Score = 68.9 bits (167), Expect = 4e-12
Identities = 59/202 (29%), Positives = 94/202 (46%), Gaps = 33/202 (16%)
Query: 61 SEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAAS---KQREMLMEDVGSEEEQ 117
+E+ V K++ +AE+ E+E E + +++ KA + K+ E E+ +EE+
Sbjct: 477 TEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEE 536
Query: 118 EEEDEAP--------------FQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPE 163
EEEDE EK+ G E+ E + + + +K++ K K +
Sbjct: 537 EEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVA 596
Query: 164 RKEK-----KMPKP-RLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEE------ 211
KE+ K+ KP + K+ V SPV+ KGK P + K K+P PK EE
Sbjct: 597 TKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 656
Query: 212 PESPPEKK----TSTSPPPEKS 229
P+SP E+K S SP EK+
Sbjct: 657 PKSPVEEKGKSPVSKSPVEEKA 678
Score = 62.0 bits (149), Expect = 5e-10
Identities = 61/247 (24%), Positives = 106/247 (42%), Gaps = 34/247 (13%)
Query: 17 QESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSED-KDVKTKKDDSHS 75
+E +A+E+ P K +E + ++ + +E+ E+ E K + ++ S
Sbjct: 496 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 555
Query: 76 AEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEE--------------- 120
SE E+ + + + +A + A + E +E+ E +EE
Sbjct: 556 EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKS 615
Query: 121 --DEAPFQEKDSGSDEDFLMEDDDDSDYGSS--KKKNKKMVKKSKPERKEK----KMP-K 171
++P +EK +E+ S S ++K K V KS E K K K P +
Sbjct: 616 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVE 675
Query: 172 PRLKATVTPSPV---KGKGKVGR-PTASKASKEKTPSPKEE-----DEEPESPPEKKTST 222
+ K+ V SPV K K +VG+ + KE +PKEE +E+P+ PEKK +
Sbjct: 676 EKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAE 735
Query: 223 SPPPEKS 229
SP E++
Sbjct: 736 SPVKEEA 742
Score = 43.1 bits (100), Expect = 2e-04
Identities = 53/216 (24%), Positives = 92/216 (42%), Gaps = 33/216 (15%)
Query: 38 RSSPREAKNKRRSGKNSQEDSEDSE----DKDVKTKKDDSHSAEDSEDEKEDHKNVRQQR 93
+S EAK+K GK Q++ E+ E K+ K +K + +D ++K+ V+++
Sbjct: 684 KSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKE-EKPKDVPEKKKAESPVKEEA 742
Query: 94 QAASKAASKQREMLMEDVGSEE----EQEEEDEAPFQE---KDSGSD--------EDFLM 138
A +K ++ +E EE +QE+E E E ++ GSD ED +
Sbjct: 743 VAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAV 802
Query: 139 E---------DDDDSDYGSSKKKNKKMVKKS---KPERKEKKMPKPRLKATVTPSPVKGK 186
+ + + GS +++ K +V P ++K K K VT + K
Sbjct: 803 NGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKIT 862
Query: 187 GKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTST 222
+ G +K T + K E+ E E+ EK ST
Sbjct: 863 SEGGDGATKYITKSVTVTQKVEEHE-ETFEEKLVST 897
Score = 33.9 bits (76), Expect = 0.13
Identities = 45/229 (19%), Positives = 80/229 (34%), Gaps = 15/229 (6%)
Query: 24 EDYGRDSGP--PTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSED 81
E+ G+ P P ++ SP GK+ S E K S
Sbjct: 623 EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPV 682
Query: 82 EKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDD 141
K + + + + ++ E +++ EE+ E+++E P + E + E+
Sbjct: 683 PKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEA 742
Query: 142 DDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKA------TVTPSPVKGKGKVGRPTAS 195
+K + K++K E K + K + KA S KG A
Sbjct: 743 VAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAV 802
Query: 196 KASKEKTPSPKEEDEEPESPPEKKTST-------SPPPEKSGDEGSEDE 237
E ++E +E S E++ SP EK G + SE++
Sbjct: 803 NGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEK 851
Score = 33.5 bits (75), Expect = 0.17
Identities = 26/129 (20%), Positives = 51/129 (39%), Gaps = 16/129 (12%)
Query: 114 EEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPR 173
EE + E++++ +E + E+ + ++ KK K+ +PE +E+++ +
Sbjct: 458 EETKVEDEKSEMEEALTAITEELAVSMKEE-------KKEAAEEKEEEPEAEEEEVAAKK 510
Query: 174 LKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEG 233
T VK + KE+ +EE+EE E + ++ E
Sbjct: 511 SPVKATAPEVK---------EEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEK 561
Query: 234 SEDEAPSGE 242
E E GE
Sbjct: 562 EEGEQEEGE 570
Score = 30.0 bits (66), Expect = 1.9
Identities = 14/50 (28%), Positives = 26/50 (52%)
Query: 194 ASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGSEDEAPSGED 243
A +EK + +E++EEPE+ E+ + P + + E E+E E+
Sbjct: 481 AVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE 530
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 71.6 bits (174), Expect = 6e-13
Identities = 56/210 (26%), Positives = 99/210 (47%), Gaps = 19/210 (9%)
Query: 43 EAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASK 102
EA+ + + K S + E K+ + +K++ E+ E+E E K+ + + + K S
Sbjct: 124 EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSS 183
Query: 103 QREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKP 162
++E G +EE E E EA +E ++ ++ ++ S+ ++K++ K KP
Sbjct: 184 EKEE-----GEQEEGETEAEAEGEEAEAKEEKKV----EEKSEEVATKEELVADAKVEKP 234
Query: 163 ERKEKKMPKPRL----KATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEE------P 212
E+ + +PK + K+ V SPV+ KGK P + K K+P PK EE
Sbjct: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVS 294
Query: 213 ESPPEKKTSTSPPPEKSGDEGSEDEAPSGE 242
+SP E+K + P + S+ E GE
Sbjct: 295 KSPVEEKAKSPVPKSPVEEAKSKAEVGKGE 324
Score = 68.9 bits (167), Expect = 4e-12
Identities = 59/202 (29%), Positives = 94/202 (46%), Gaps = 33/202 (16%)
Query: 61 SEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAAS---KQREMLMEDVGSEEEQ 117
+E+ V K++ +AE+ E+E E + +++ KA + K+ E E+ +EE+
Sbjct: 101 TEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEE 160
Query: 118 EEEDEAP--------------FQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPE 163
EEEDE EK+ G E+ E + + + +K++ K K +
Sbjct: 161 EEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVA 220
Query: 164 RKEK-----KMPKP-RLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEE------ 211
KE+ K+ KP + K+ V SPV+ KGK P + K K+P PK EE
Sbjct: 221 TKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 280
Query: 212 PESPPEKK----TSTSPPPEKS 229
P+SP E+K S SP EK+
Sbjct: 281 PKSPVEEKGKSPVSKSPVEEKA 302
Score = 62.0 bits (149), Expect = 5e-10
Identities = 61/247 (24%), Positives = 106/247 (42%), Gaps = 34/247 (13%)
Query: 17 QESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSED-KDVKTKKDDSHS 75
+E +A+E+ P K +E + ++ + +E+ E+ E K + ++ S
Sbjct: 120 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 179
Query: 76 AEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEE--------------- 120
SE E+ + + + +A + A + E +E+ E +EE
Sbjct: 180 EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKS 239
Query: 121 --DEAPFQEKDSGSDEDFLMEDDDDSDYGSS--KKKNKKMVKKSKPERKEK----KMP-K 171
++P +EK +E+ S S ++K K V KS E K K K P +
Sbjct: 240 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVE 299
Query: 172 PRLKATVTPSPV---KGKGKVGR-PTASKASKEKTPSPKEE-----DEEPESPPEKKTST 222
+ K+ V SPV K K +VG+ + KE +PKEE +E+P+ PEKK +
Sbjct: 300 EKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAE 359
Query: 223 SPPPEKS 229
SP E++
Sbjct: 360 SPVKEEA 366
Score = 43.1 bits (100), Expect = 2e-04
Identities = 53/216 (24%), Positives = 92/216 (42%), Gaps = 33/216 (15%)
Query: 38 RSSPREAKNKRRSGKNSQEDSEDSE----DKDVKTKKDDSHSAEDSEDEKEDHKNVRQQR 93
+S EAK+K GK Q++ E+ E K+ K +K + +D ++K+ V+++
Sbjct: 308 KSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKE-EKPKDVPEKKKAESPVKEEA 366
Query: 94 QAASKAASKQREMLMEDVGSEE----EQEEEDEAPFQE---KDSGSD--------EDFLM 138
A +K ++ +E EE +QE+E E E ++ GSD ED +
Sbjct: 367 VAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAV 426
Query: 139 E---------DDDDSDYGSSKKKNKKMVKKS---KPERKEKKMPKPRLKATVTPSPVKGK 186
+ + + GS +++ K +V P ++K K K VT + K
Sbjct: 427 NGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKIT 486
Query: 187 GKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTST 222
+ G +K T + K E+ E E+ EK ST
Sbjct: 487 SEGGDGATKYITKSVTVTQKVEEHE-ETFEEKLVST 521
Score = 33.9 bits (76), Expect = 0.13
Identities = 45/229 (19%), Positives = 80/229 (34%), Gaps = 15/229 (6%)
Query: 24 EDYGRDSGP--PTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSED 81
E+ G+ P P ++ SP GK+ S E K S
Sbjct: 247 EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPV 306
Query: 82 EKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDD 141
K + + + + ++ E +++ EE+ E+++E P + E + E+
Sbjct: 307 PKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEA 366
Query: 142 DDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKA------TVTPSPVKGKGKVGRPTAS 195
+K + K++K E K + K + KA S KG A
Sbjct: 367 VAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAV 426
Query: 196 KASKEKTPSPKEEDEEPESPPEKKTST-------SPPPEKSGDEGSEDE 237
E ++E +E S E++ SP EK G + SE++
Sbjct: 427 NGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEK 475
Score = 33.5 bits (75), Expect = 0.17
Identities = 26/129 (20%), Positives = 51/129 (39%), Gaps = 16/129 (12%)
Query: 114 EEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPR 173
EE + E++++ +E + E+ + ++ KK K+ +PE +E+++ +
Sbjct: 82 EETKVEDEKSEMEEALTAITEELAVSMKEE-------KKEAAEEKEEEPEAEEEEVAAKK 134
Query: 174 LKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEG 233
T VK + KE+ +EE+EE E + ++ E
Sbjct: 135 SPVKATAPEVK---------EEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEK 185
Query: 234 SEDEAPSGE 242
E E GE
Sbjct: 186 EEGEQEEGE 194
Score = 30.0 bits (66), Expect = 1.9
Identities = 14/50 (28%), Positives = 26/50 (52%)
Query: 194 ASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGSEDEAPSGED 243
A +EK + +E++EEPE+ E+ + P + + E E+E E+
Sbjct: 105 AVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE 154
>gi|55956788 nucleolin [Homo sapiens]
Length = 710
Score = 69.7 bits (169), Expect = 2e-12
Identities = 51/180 (28%), Positives = 83/180 (46%), Gaps = 17/180 (9%)
Query: 6 RNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKD 65
+N K D S +E DD++ED D + P K + + ED ED ED +
Sbjct: 138 KNAKKED-SDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDE 196
Query: 66 VKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPF 125
DD +DSE+E + A K A+K + ++V +E++EE+DE
Sbjct: 197 ----DDDDDEEDDSEEE------AMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDE--- 243
Query: 126 QEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKG 185
++D DED EDDDD D +++ ++ K P +++K+M K + V+G
Sbjct: 244 -DEDDDDDED--DEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEG 300
Score = 51.2 bits (121), Expect = 8e-07
Identities = 51/210 (24%), Positives = 83/210 (39%), Gaps = 57/210 (27%)
Query: 33 PTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQ 92
P KK + P + ++GKN++++ D E+ D D ED EDE ED +
Sbjct: 122 PGKKGAAIPAKGA---KNGKNAKKEDSDEEEDD-----DSEEDEEDDEDEDEDEDEIEPA 173
Query: 93 RQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKK 152
A+ AA SE+E +E+DE DED +DDD+ D
Sbjct: 174 AMKAAAAAP----------ASEDEDDEDDE---------DDED---DDDDEED------- 204
Query: 153 NKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEP 212
+ +E+ M TP+ K KV A ++++ +EDE+
Sbjct: 205 ----------DSEEEAME-------TTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDD 247
Query: 213 ESPPEKKTSTSPPPEKSGDEGSED---EAP 239
+ + + E+ +E E+ EAP
Sbjct: 248 DDDEDDEDDDDEDDEEEEEEEEEEPVKEAP 277
Score = 38.9 bits (89), Expect = 0.004
Identities = 46/195 (23%), Positives = 70/195 (35%), Gaps = 47/195 (24%)
Query: 96 ASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKK--- 152
A K ++M EE+ E+E+ + +E DS +E + + +S KK
Sbjct: 7 AGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVV 66
Query: 153 -NKKMVKKSKPERKE-----KKMPKPRLKATVTPSP----------------VKGKGKVG 190
K V + P +K KK K TVTP+ V GK G
Sbjct: 67 SPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKG 126
Query: 191 RPTASKASK-----EKTPSPKEEDEEPESPPE-----------------KKTSTSPPPEK 228
+K +K +K S +EED++ E E K + +P E
Sbjct: 127 AAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASED 186
Query: 229 SGDEGSEDEAPSGED 243
DE ED+ +D
Sbjct: 187 EDDEDDEDDEDDDDD 201
>gi|195947391 RAD51 associated protein 1 isoform a [Homo sapiens]
Length = 352
Score = 68.9 bits (167), Expect = 4e-12
Identities = 63/216 (29%), Positives = 94/216 (43%), Gaps = 26/216 (12%)
Query: 40 SPREAKNKRRSGKNSQEDS-EDSEDKDVKTKKDDSHSAE----------DSEDEKEDHKN 88
S +E + +NSQ+ S E ++T H + D ++D
Sbjct: 106 SVKELPTVTTNVQNSQDKSIEKHGSSKIETMNKSPHISNCSVASDYLDLDKITVEDDVGG 165
Query: 89 VRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQE-KDSGSDEDFLMEDDDDSDYG 147
V+ +R+AASKAA++QR++L+E GS+ + + E F +DS D DF +D+D D+
Sbjct: 166 VQGKRKAASKAAAQQRKILLE--GSDGDSANDTEPDFAPGEDSEDDSDFCESEDNDEDFS 223
Query: 148 SSKKK----NKKMVKKSKPERKEKKMPKPRLKATVT-----PSPVKGKGKVGRPTASKAS 198
K K KK VK P K++K K + A VT P+ VK + + P S
Sbjct: 224 MRKSKVKEIKKKEVKVKSPVEKKEKKSKSKCNALVTSVDSAPAAVKSESQ-SLPKKVSLS 282
Query: 199 KEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGS 234
+ T P E S KK PP G S
Sbjct: 283 SDTTRKPLE--IRSPSAESKKPKWVPPAASGGSRSS 316
Score = 27.7 bits (60), Expect = 9.4
Identities = 19/64 (29%), Positives = 31/64 (48%), Gaps = 6/64 (9%)
Query: 12 DYSQFQESDDADEDYG------RDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKD 65
D S F ES+D DED+ ++ K++S + + K +S N+ S DS
Sbjct: 208 DDSDFCESEDNDEDFSMRKSKVKEIKKKEVKVKSPVEKKEKKSKSKCNALVTSVDSAPAA 267
Query: 66 VKTK 69
VK++
Sbjct: 268 VKSE 271
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 65.1 bits (157), Expect = 5e-11
Identities = 59/231 (25%), Positives = 104/231 (45%), Gaps = 24/231 (10%)
Query: 6 RNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKD 65
++ K D + ES DA+ +D TKK + ++ K+ + K +S D+E D
Sbjct: 319 KDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKK--YPESTDTESGD 376
Query: 66 VKTKKDDSHS---AEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDE 122
K ++DS + A ++D+K+D K + + S+ SK+ + +E+++++D
Sbjct: 377 AKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQ-------KDEKKDKKDS 429
Query: 123 APFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERK---EKKMPKPRLKATVT 179
+K +DE+ D DS+ KK KK KK K + K +KK K ++T
Sbjct: 430 KTDNKKSVKNDEE---STDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEM 486
Query: 180 PSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSG 230
S ++ K K SKEK S K+ ++ E + K+G
Sbjct: 487 ESDLELK------KDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTG 531
Score = 56.2 bits (134), Expect = 2e-08
Identities = 62/243 (25%), Positives = 110/243 (45%), Gaps = 25/243 (10%)
Query: 12 DYSQFQESDDADEDYGRDSGPPTKKI--RSSPREAKNKRRSGKNSQEDSED--SEDKDVK 67
+YSQ S + Y + + TKK +SS E+++ + + K+S++ ++ +DK
Sbjct: 267 NYSQ-NNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKD 325
Query: 68 TKKD-DSHSAE--DSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAP 124
KKD +S AE DS+DE++D K +++ + K ++ D S + ++ +++
Sbjct: 326 VKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSR 385
Query: 125 FQEKDSGSDE--------DFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKA 176
+K S +D+ F + + + + S+K KK K SK + KK K ++
Sbjct: 386 NLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTD--NKKSVKNDEES 443
Query: 177 TVTPSPVKGKGKVGRPTASKASKEKTPSPKEED-------EEPESPPEKKTSTSPPPEKS 229
T S KG K G+ K K+ K++D E ES E K EK
Sbjct: 444 TDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKK 503
Query: 230 GDE 232
G +
Sbjct: 504 GSK 506
Score = 49.3 bits (116), Expect = 3e-06
Identities = 44/195 (22%), Positives = 83/195 (42%), Gaps = 28/195 (14%)
Query: 64 KDVK--TKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEED 121
KD K KK +EDS+D K+D K V++ + K +++ D S + ++E
Sbjct: 286 KDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDE-- 343
Query: 122 EAPFQEKDSGSDEDFLMEDD-----------DDSDYGSSK--KKNKKMVKKSKPERKEKK 168
KD+ D+ L +DD D++ G +K + + + +KK+ +KK
Sbjct: 344 -----RKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKK 398
Query: 169 MPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEK 228
K +T + S ++ K + K K+ K ++++ E+ T P+
Sbjct: 399 DAKKITFSTDSESELESK------ESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKG 452
Query: 229 SGDEGSEDEAPSGED 243
+G +DE +D
Sbjct: 453 DSKKGKKDEKKGKKD 467
Score = 44.7 bits (104), Expect = 7e-05
Identities = 56/225 (24%), Positives = 88/225 (39%), Gaps = 43/225 (19%)
Query: 17 QESDDADEDYGRDSGPPTKKIRSSPREAKN---KRRSGKNSQEDSEDSEDKDVKTKKDDS 73
+ES DAD + DS K + +++K K+ + KN++ +S D++ KKD
Sbjct: 441 EESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMES---DLELKKDKK 497
Query: 74 HSAEDSEDEKEDHKNVRQQRQA-------ASKAASKQREMLMEDVGSEEEQEEEDEAPFQ 126
HS E +K+ K+ R+ ++ +SK K + GS+ E EE P
Sbjct: 498 HSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIK---GSDTESEESLYKPGA 554
Query: 127 EKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGK 186
+K D+SD S+ K + + K KK + K
Sbjct: 555 KKKI-----------DESDGTSANSKMEGLESKRGFRMSSKK------------TTFNEK 591
Query: 187 GKVGRPTASKASKEKTPSPKEEDEEPESPPEKK---TSTSPPPEK 228
G+ S+EK P P E P SP ++ PPP K
Sbjct: 592 GEKASTGRVPPSREKPPLPACEPSLP-SPKVRRLCWCKMPPPPPK 635
Score = 44.3 bits (103), Expect = 1e-04
Identities = 53/237 (22%), Positives = 94/237 (39%), Gaps = 19/237 (8%)
Query: 6 RNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKD 65
RN K + ++ D + DS + S E K+K K+S+ D++ S D
Sbjct: 385 RNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDK----KDSKTDNKKSVKND 440
Query: 66 VKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPF 125
++ DS DS+ K+D K ++ + K K + E E + E + +
Sbjct: 441 EESTDADSEPKGDSKKGKKDEKKGKKDSKKDDK--KKDAKKNAESTEMESDLELKKDKKH 498
Query: 126 QEKDSGSDEDFLME-----DDDDSDYGSSKKKNKKMVKKSK--PERKEKKMPKPRLKATV 178
++ GS +D + + D+++ S K K K K E+ + KP K +
Sbjct: 499 SKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKI 558
Query: 179 -----TPSPVKGKGKVGRPTASKASKEKTPSPK-EEDEEPESPPEKKTSTSPPPEKS 229
T + K +G + +SK+ T + K E+ PP ++ P E S
Sbjct: 559 DESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSREKPPLPACEPS 615
Score = 40.8 bits (94), Expect = 0.001
Identities = 50/233 (21%), Positives = 96/233 (41%), Gaps = 32/233 (13%)
Query: 34 TKKIRSSPR---EAKNKRRSGKN-SQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNV 89
+KK +SS E++N + KN SQ+D +DS++ +KK ++ + K+D K
Sbjct: 172 SKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKN----SKKTNTEFLHTKNNPKKDLKRS 227
Query: 90 RQQRQAASKAASKQR---EMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLME------- 139
+ S+ S+ + LM VG +++ +A + + +++ ++
Sbjct: 228 KTSNDPISEICSENSLNVDFLML-VGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKK 286
Query: 140 ---------DDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVG 190
D +S+ KK+ K VKK+ + +KK K K T + G K
Sbjct: 287 DTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVK---KDTESTDAESGDSKDE 343
Query: 191 RPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGSEDEAPSGED 243
R K K+ K++D + + P T + + D + +A +D
Sbjct: 344 RKDTKKDKKKLKKDDKKKDTK-KYPESTDTESGDAKDARNDSRNLKKASKNDD 395
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 64.7 bits (156), Expect = 7e-11
Identities = 62/250 (24%), Positives = 99/250 (39%), Gaps = 21/250 (8%)
Query: 9 KVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDS-EDKDVK 67
K + S +ES D D++ + P K ++ + AK + K+S DS+ S ED+ K
Sbjct: 122 KASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPK 181
Query: 68 TKKDDSHSAEDSEDEKEDHKNVRQQRQAAS-KAASKQREMLMEDVGSEEEQEEEDEAPFQ 126
+K K K R + A+ KAAS S + EE++A
Sbjct: 182 NQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSS---SSSSSSSDDSEEEKAAAT 238
Query: 127 EKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPR---LKATVTPSPV 183
K + + + + + ++K + S E ++KK K + + PS
Sbjct: 239 PKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAP 298
Query: 184 KGKGKVGRPTASKASKEKTPSPKEED---------EEPESPPEK----KTSTSPPPEKSG 230
K +G KA +++ P ED EE + PP K K +T PPP K
Sbjct: 299 PPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKA 358
Query: 231 DEGSEDEAPS 240
E S D + S
Sbjct: 359 AESSSDSSDS 368
Score = 52.4 bits (124), Expect = 4e-07
Identities = 55/248 (22%), Positives = 97/248 (39%), Gaps = 25/248 (10%)
Query: 3 RPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSE 62
+ V ++ V+ S+ SD++D + PPTK + S +A K K + E S DS
Sbjct: 311 KAVEKQQPVESSE-DSSDESDSSSEEEKKPPTKAVVS---KATTKPPPAKKAAESSSDSS 366
Query: 63 DKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREML--------------- 107
D D ++ D++ S + +K + A K A+ ++ +
Sbjct: 367 DSD-SSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSS 425
Query: 108 MEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEK 167
E+ S E+E+ + K + + L + GS + S E +E+
Sbjct: 426 SEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDS--DSSSSEEEEE 483
Query: 168 KMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEK-KTSTSPPP 226
K K +K P V G +P ++K K ++ + D+ E EK K SP P
Sbjct: 484 KTSKSAVKK--KPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRP 541
Query: 227 EKSGDEGS 234
+ G+
Sbjct: 542 QAPKANGT 549
Score = 43.9 bits (102), Expect = 1e-04
Identities = 44/180 (24%), Positives = 73/180 (40%), Gaps = 25/180 (13%)
Query: 66 VKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPF 125
V K S+ DSED E+ + V Q A KAA + + + +A
Sbjct: 74 VAKKAKKKASSSDSEDSSEEEEEV--QGPPAKKAAVPAKRVGLPP----------GKAAA 121
Query: 126 QEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPS---- 181
+ +S S E+ +DDD+ D +K + + K KP+ K K P + K++ + S
Sbjct: 122 KASESSSSEES-SDDDDEED-----QKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSS 175
Query: 182 ---PVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGSEDEA 238
P K + P KA + P P + + +S+S S D+ E++A
Sbjct: 176 EDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKA 235
Score = 43.9 bits (102), Expect = 1e-04
Identities = 51/220 (23%), Positives = 85/220 (38%), Gaps = 48/220 (21%)
Query: 30 SGPPTKKIRSS--PREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHK 87
S PP KK + P++A K++ ++S++ S++S+ + KK + + K
Sbjct: 296 SAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPP-- 353
Query: 88 NVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYG 147
A KAA + S+ + E+DEAP K +G+
Sbjct: 354 -------PAKKAAESSSD------SSDSDSSEDDEAP--SKPAGT--------------- 383
Query: 148 SSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGK-VGRPTASKASKEKTPSPK 206
+ NK V P K PK PV G K + R S +S+E++ S +
Sbjct: 384 TKNSSNKPAVTTKSPAVKPAAAPK---------QPVGGGQKLLTRKADSSSSEEESSSSE 434
Query: 207 EEDEEPESPPEKKTSTSPP----PEKSGDEGSEDEAPSGE 242
EE + K +T+ P K +GS D + +
Sbjct: 435 EEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSD 474
Score = 37.0 bits (84), Expect = 0.016
Identities = 28/109 (25%), Positives = 43/109 (39%), Gaps = 18/109 (16%)
Query: 149 SKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEE 208
+KKK + E +E+ P KA V P K G A+KAS+ + +
Sbjct: 78 AKKKASSSDSEDSSEEEEEVQGPPAKKAAV---PAKRVGLPPGKAAAKASESSSSEESSD 134
Query: 209 DEEPES----------PPEKKTSTSPP-----PEKSGDEGSEDEAPSGE 242
D++ E P+ K + +PP + D SEDE P +
Sbjct: 135 DDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQ 183
Score = 36.2 bits (82), Expect = 0.027
Identities = 23/79 (29%), Positives = 35/79 (44%), Gaps = 14/79 (17%)
Query: 165 KEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSP 224
K K+P+ +L+A G V + KAS + EE+EE + PP KK +
Sbjct: 59 KSAKVPERKLQAN---------GPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPA 109
Query: 225 -----PPEKSGDEGSEDEA 238
PP K+ + SE +
Sbjct: 110 KRVGLPPGKAAAKASESSS 128
Score = 35.0 bits (79), Expect = 0.059
Identities = 27/108 (25%), Positives = 44/108 (40%), Gaps = 13/108 (12%)
Query: 147 GSSKKKNKKMVKKSKPE---RKEKKMPKPRLKATVTPSPVKG--KGKVGRPTASKASKEK 201
G KK KK S E +E+++ P K P+ G GK + +S E+
Sbjct: 72 GPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEE 131
Query: 202 TPSPKEEDEEPESP------PEKKTSTSPPPEKSGDEGSEDEAPSGED 243
+ +E+++ + P P+ K + +PP K D S ED
Sbjct: 132 SSDDDDEEDQKKQPVQKGVKPQAKAAKAPP--KKAKSSDSDSDSSSED 177
Score = 35.0 bits (79), Expect = 0.059
Identities = 39/162 (24%), Positives = 63/162 (38%), Gaps = 7/162 (4%)
Query: 17 QESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSA 76
Q S D+ D S ++ ++S K K + S+ + K K + +S S+
Sbjct: 464 QGSRDSSSDSDSSSSEEEEE-KTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSS 522
Query: 77 EDSEDEKEDH-KNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDE---APFQEKDSGS 132
+DS +E+E+ K R A KA ++ +EEE+E A SGS
Sbjct: 523 DDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGS 582
Query: 133 DEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERK--EKKMPKP 172
+ + KK K + P+RK EK+ P
Sbjct: 583 LKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSP 624
>gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homolog
[Homo sapiens]
Length = 666
Score = 62.4 bits (150), Expect = 3e-10
Identities = 55/235 (23%), Positives = 93/235 (39%), Gaps = 32/235 (13%)
Query: 21 DADEDYGRDSGPPTKK------------IRSSPREAKNKRRSGKNSQEDSEDSEDKDVKT 68
++D+D DSG P+ K S + ++R ++ + D ED D
Sbjct: 44 ESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSD 103
Query: 69 KKDDSHSAEDSEDEKEDHKNV----RQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAP 124
S S ++DE E H++ + + + KA S + ED + + E+ +
Sbjct: 104 VDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSD 163
Query: 125 FQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVK 184
+E+ GSDED L DDD ++ + + + S ER++ + K
Sbjct: 164 DEERAQGSDEDKLQNSDDDEKMQNTDDEERPQL--SDDERQQLSEEE------------K 209
Query: 185 GKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDE--GSEDE 237
RP AS EK S EE + + + S P+ S +E S+DE
Sbjct: 210 ANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDE 264
Score = 52.0 bits (123), Expect = 5e-07
Identities = 52/233 (22%), Positives = 91/233 (39%), Gaps = 28/233 (12%)
Query: 19 SDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAED 78
+DD DE + D G + S + + + G+ ED D D + DD A+
Sbjct: 114 NDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGR---EDKSDQSDDEKIQNSDDEERAQG 170
Query: 79 SEDEK-----EDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSD 133
S+++K +D K + + + +R+ L E EE+ +DE P S +D
Sbjct: 171 SDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSE----EEKANSDDERPVA---SDND 223
Query: 134 EDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPT 193
++ DD++ S ++K ++ S ER + + R K + G +
Sbjct: 224 DEKQNSDDEEQPQLSDEEK----MQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDS 279
Query: 194 ASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDE---GSEDEAPSGED 243
+ + K + D E +S T P + SG G D+ SG D
Sbjct: 280 EDEVLRMKRKNAIASDSEADS------DTEVPKDNSGTMDLFGGADDISSGSD 326
Score = 47.8 bits (112), Expect = 9e-06
Identities = 56/251 (22%), Positives = 97/251 (38%), Gaps = 35/251 (13%)
Query: 18 ESDDADEDYGRDSGPPTKKIRS------SPREAKNKRRSGKNSQED--SEDSEDKDVKTK 69
E++ D D G DS + S S + + SG+ S ++ +DSED+
Sbjct: 15 EAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGAS-- 72
Query: 70 KDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKD 129
HS D+ E+ D+++ +R S + + GSE ++EDE D
Sbjct: 73 ---HHSGSDNHSERSDNRSEASER---SDHEDNDPSDVDQHSGSEAPNDDEDEG--HRSD 124
Query: 130 SGSD----EDFLMEDDDDSDYGSSKKKNK---KMVKKSKPERKEKKMPKPRLKATVTPSP 182
GS E DD +G K ++ + ++ S E + + + +L+ +
Sbjct: 125 GGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEK 184
Query: 183 VKGKGKVGRPTASK------ASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDE---- 232
++ RP S + +EK S E ++ EK+ S + DE
Sbjct: 185 MQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQ 244
Query: 233 GSEDEAPSGED 243
S+DE P D
Sbjct: 245 NSDDERPQASD 255
Score = 34.3 bits (77), Expect = 0.10
Identities = 38/199 (19%), Positives = 70/199 (35%), Gaps = 14/199 (7%)
Query: 57 DSED--SEDKDVKTKKDDSHSAEDSEDEKED-------HKNVRQQRQAASKAASKQREML 107
D ED D D + ++ DS S DS+ ++E+ + Q + +E+
Sbjct: 3 DMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELF 62
Query: 108 ---MEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPER 164
ED G+ ++ + + S + E ED+D SD + + + E
Sbjct: 63 GDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDV--DQHSGSEAPNDDEDEG 120
Query: 165 KEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSP 224
+A + K GR S S ++ +++E + E K S
Sbjct: 121 HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD 180
Query: 225 PPEKSGDEGSEDEAPSGED 243
EK + E+ +D
Sbjct: 181 DDEKMQNTDDEERPQLSDD 199
Score = 33.5 bits (75), Expect = 0.17
Identities = 44/216 (20%), Positives = 83/216 (38%), Gaps = 32/216 (14%)
Query: 12 DYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKD 71
D + Q SDD DE ++ R+ ++ + E S++ D K D
Sbjct: 172 DEDKLQNSDD-DEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSD 230
Query: 72 DSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSG 131
D + S++EK +N +R AS + S++E+E++ ++ E G
Sbjct: 231 DEEQPQLSDEEKM--QNSDDERPQASDEEHRH---------SDDEEEQDHKS---ESARG 276
Query: 132 SDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGR 191
SD ED+ + K K + + ++PK + T G +
Sbjct: 277 SDS----EDE------VLRMKRKNAIASDSEADSDTEVPKDN---SGTMDLFGGADDI-- 321
Query: 192 PTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPE 227
++ ++K P+P + +E P+ + P PE
Sbjct: 322 -SSGSDGEDKPPTPGQPVDE-NGLPQDQQEEEPIPE 355
>gi|21396500 HIRA interacting protein 3 [Homo sapiens]
Length = 556
Score = 62.0 bits (149), Expect = 5e-10
Identities = 58/264 (21%), Positives = 113/264 (42%), Gaps = 32/264 (12%)
Query: 2 SRPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKK---IRSSPREAKNKRRSGKNSQEDS 58
S P R R + S+ + DY GPP K SP + +N RR+ K +E S
Sbjct: 87 SDPERKRFRFNSESESGSEASSPDY---FGPPAKNGVAAEVSPAKEENPRRASKAVEESS 143
Query: 59 EDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQE 118
++ +D+ ++ + E SE+E++ +K +++ K A + + + + EE E
Sbjct: 144 DEERQRDLPAQRGE----ESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQ--AREESE 197
Query: 119 EEDEAPFQ------EKDSGSDEDFLMEDDDDSDYGSSKKKNKK--MVKKSKPERKEKKMP 170
E + P Q E + G+ E + + + + KK+ ++ + ++ K E +EK
Sbjct: 198 ESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDW 257
Query: 171 KPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSG 230
KPR ++ + + + + +K + S +E+ E S + PP ++
Sbjct: 258 KPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKS 317
Query: 231 DE------------GSEDEAPSGE 242
++ SEDE SG+
Sbjct: 318 EDRTQLKGGKRLSGSSEDEEDSGK 341
Score = 50.1 bits (118), Expect = 2e-06
Identities = 41/230 (17%), Positives = 100/230 (43%), Gaps = 14/230 (6%)
Query: 14 SQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQED--SEDSEDKDVKTKKD 71
S+ Q ++++E KK+ + + K+ + S + S+E+ ++ E ++ + +++
Sbjct: 188 SRKQAREESEESEAEPVQRTAKKVEGN-KGTKSLKESEQESEEEILAQKKEQREEEVEEE 246
Query: 72 DSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSG 131
+ E+ D K ++ +++ A + + KQ+ +G + +EE+ EA DSG
Sbjct: 247 EKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSG 306
Query: 132 SDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGR 191
D + ++ + ++ K K + S + ++ +P K + + ++G
Sbjct: 307 RDREPPVQRKSED---RTQLKGGKRLSGSSEDEEDSGKGEPTAKGS------RKMARLGS 357
Query: 192 PTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGSEDEAPSG 241
+ ++ E+ S E P+ E+K +S + G S + G
Sbjct: 358 TSGEESDLEREVSDSEAGGGPQG--ERKNRSSKKSSRKGRTRSSSSSSDG 405
>gi|156104891 general transcription factor IIF, polypeptide 1, 74kDa
[Homo sapiens]
Length = 517
Score = 62.0 bits (149), Expect = 5e-10
Identities = 59/227 (25%), Positives = 93/227 (40%), Gaps = 15/227 (6%)
Query: 19 SDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDS--EDSEDKDVKTKKDD--SH 74
S DA + G + G K + +P +++ K +D EDS+D D + ++ D S
Sbjct: 217 SSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSD 276
Query: 75 SAEDSEDEKEDHKNVRQQRQAASKA--ASKQREMLMEDVGSEEEQEEEDE--APF-QEKD 129
+ S++E E QQ + S E E+ EE++EEE+E AP QEK
Sbjct: 277 GSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKK 336
Query: 130 SGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKG-- 187
D + ++SD S M KK P ++E+K + P +G
Sbjct: 337 RRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGS 396
Query: 188 --KVGRPTASKASKEKTPS--PKEEDEEPESPPEKKTSTSPPPEKSG 230
R ASK + K S P + ++ P+ + S P SG
Sbjct: 397 TSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSG 443
Score = 49.7 bits (117), Expect = 2e-06
Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 31/193 (16%)
Query: 55 QEDSEDSEDKDVKTKKDDS----HSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMED 110
Q+ ED E+K+ + ++ S H ED + D + + A K+ +
Sbjct: 185 QDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGG 244
Query: 111 VGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMP 170
++++ +DEA F++ D G DF ++ D GSS + + K P+++E
Sbjct: 245 RKKKKKKGSDDEA-FEDSDDG---DFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGP-- 298
Query: 171 KPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSG 230
KG + +S+ S+E+ P EED+E E EKK T P EK
Sbjct: 299 ---------------KGVDEQSDSSEESEEE--KPPEEDKEEEE--EKKAPT--PQEKKR 337
Query: 231 DEGSEDEAPSGED 243
+ S +E+ S E+
Sbjct: 338 RKDSSEESDSSEE 350
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 61.6 bits (148), Expect = 6e-10
Identities = 49/243 (20%), Positives = 98/243 (40%), Gaps = 10/243 (4%)
Query: 2 SRPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDS 61
SR R++ S +D R P K+ +S R R ++ ++D+ +
Sbjct: 324 SRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREK 383
Query: 62 EDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEED 121
+ + K+ D + E E+E K R + + K K RE E E ++E +
Sbjct: 384 IKEKERVKEKDREKEREREKEREKEKE-RGKNKDRDKEREKDREKDKEKDREREREKEHE 442
Query: 122 EAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKK---------MVKKSKPERKEKKMPKP 172
+ +EK+ D++ E D + +KK+KK ++S+ +E++ +
Sbjct: 443 KDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRS 502
Query: 173 RLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDE 232
R + + K K R + ++ +K ++E + E++ STS + +
Sbjct: 503 RSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRD 562
Query: 233 GSE 235
G E
Sbjct: 563 GKE 565
Score = 45.1 bits (105), Expect = 6e-05
Identities = 52/237 (21%), Positives = 94/237 (39%), Gaps = 32/237 (13%)
Query: 27 GRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSED---SEDKDVKTKKDDSHSAEDSEDEK 83
GR K RSS + ++RS + S + S KD + K S + +
Sbjct: 306 GRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERR 365
Query: 84 EDHK--NVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDD 141
+ + R +R+ + ++ + +D E E+E+E E +EK+ G ++D + +
Sbjct: 366 KSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKERE---KEKERGKNKD--RDKE 420
Query: 142 DDSDYGSSKKKNKKMVK-----------KSKPERKEKKMPKPRLKATVTPSPVKGKGKVG 190
+ D K+K+++ + K K + KEK+ K R K + K K
Sbjct: 421 REKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK-EIDEKRKKDKKSRT 479
Query: 191 RPTASKASKEKTPSPKE-----EDEEPESPP-----EKKTSTSPPPEKSGDEGSEDE 237
P + AS+ S +E SP ++K+S SP P + + E
Sbjct: 480 PPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 536
Score = 42.0 bits (97), Expect = 5e-04
Identities = 40/195 (20%), Positives = 79/195 (40%), Gaps = 19/195 (9%)
Query: 41 PREAKNKRRSG----KNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAA 96
P K+ R G +++ S S + K+ S S + + R++ ++
Sbjct: 295 PESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSP 354
Query: 97 SKAASKQREML-------MEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSS 149
K SK RE D + ++ +++ +EKD + + E + + + G +
Sbjct: 355 HKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKN 414
Query: 150 KKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEED 209
K ++K+ +K + + KEK + R K K + K K + + KE D
Sbjct: 415 KDRDKER-EKDREKDKEKDREREREK-----EHEKDRDKEKEKEQDKEKEREKDRSKEID 468
Query: 210 EEPESPPEKKTSTSP 224
E+ + +KK+ T P
Sbjct: 469 EKRKK--DKKSRTPP 481
Score = 34.3 bits (77), Expect = 0.10
Identities = 27/163 (16%), Positives = 65/163 (39%), Gaps = 14/163 (8%)
Query: 17 QESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDS--- 73
+ D ++D +D +K R+ + ++ K + + + S++ D K KKD
Sbjct: 420 EREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRT 479
Query: 74 -----HSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEK 128
+++ S + + R + + S SK + S + ++D+ +E+
Sbjct: 480 PPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKER 539
Query: 129 DSGSDE------DFLMEDDDDSDYGSSKKKNKKMVKKSKPERK 165
D S+ + + +D D +KN +K+ + ++
Sbjct: 540 DHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKE 582
Score = 33.9 bits (76), Expect = 0.13
Identities = 29/147 (19%), Positives = 64/147 (43%), Gaps = 17/147 (11%)
Query: 17 QESDDADEDYGRDSGPP-----TKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKD 71
+E D+ + + PP +++ RSS RE +RR ++S S+ K+ +
Sbjct: 465 KEIDEKRKKDKKSRTPPRSYNASRRSRSSSRE--RRRRRSRSSSRSPRTSKTIKRKSSRS 522
Query: 72 DSHSAEDSEDEK----EDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQE 127
S + + +D+K DH + R++R+ ++ + +E+ E++ +E
Sbjct: 523 PSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDR------DGKEKLEKNSTSLKE 576
Query: 128 KDSGSDEDFLMEDDDDSDYGSSKKKNK 154
K+ + D + + D ++NK
Sbjct: 577 KEHNKEPDSSVSKEVDDKDAPRTEENK 603
Score = 33.5 bits (75), Expect = 0.17
Identities = 36/178 (20%), Positives = 69/178 (38%), Gaps = 18/178 (10%)
Query: 83 KEDHKN--VRQQRQAASKAASKQREMLMEDVGSEEE----QEEEDEAPFQEKDSGSDEDF 136
K +H N + + + +AA+K+ E +M+ V + E + E+ G
Sbjct: 252 KINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSH 311
Query: 137 LMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASK 196
S S++K + +S+ + + K R ++ +P + K + R + S+
Sbjct: 312 TRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSK-SPHKKRSKSRERRKSRSR 370
Query: 197 A--------SKEKTPSP---KEEDEEPESPPEKKTSTSPPPEKSGDEGSEDEAPSGED 243
+ ++EK KE+D E E EK+ K+ D E E +D
Sbjct: 371 SHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKD 428
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 61.6 bits (148), Expect = 6e-10
Identities = 49/243 (20%), Positives = 98/243 (40%), Gaps = 10/243 (4%)
Query: 2 SRPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDS 61
SR R++ S +D R P K+ +S R R ++ ++D+ +
Sbjct: 208 SRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREK 267
Query: 62 EDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEED 121
+ + K+ D + E E+E K R + + K K RE E E ++E +
Sbjct: 268 IKEKERVKEKDREKEREREKEREKEKE-RGKNKDRDKEREKDREKDKEKDREREREKEHE 326
Query: 122 EAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKK---------MVKKSKPERKEKKMPKP 172
+ +EK+ D++ E D + +KK+KK ++S+ +E++ +
Sbjct: 327 KDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRS 386
Query: 173 RLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDE 232
R + + K K R + ++ +K ++E + E++ STS + +
Sbjct: 387 RSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRD 446
Query: 233 GSE 235
G E
Sbjct: 447 GKE 449
Score = 45.1 bits (105), Expect = 6e-05
Identities = 52/237 (21%), Positives = 94/237 (39%), Gaps = 32/237 (13%)
Query: 27 GRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSED---SEDKDVKTKKDDSHSAEDSEDEK 83
GR K RSS + ++RS + S + S KD + K S + +
Sbjct: 190 GRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERR 249
Query: 84 EDHK--NVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDD 141
+ + R +R+ + ++ + +D E E+E+E E +EK+ G ++D + +
Sbjct: 250 KSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKERE---KEKERGKNKD--RDKE 304
Query: 142 DDSDYGSSKKKNKKMVK-----------KSKPERKEKKMPKPRLKATVTPSPVKGKGKVG 190
+ D K+K+++ + K K + KEK+ K R K + K K
Sbjct: 305 REKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK-EIDEKRKKDKKSRT 363
Query: 191 RPTASKASKEKTPSPKE-----EDEEPESPP-----EKKTSTSPPPEKSGDEGSEDE 237
P + AS+ S +E SP ++K+S SP P + + E
Sbjct: 364 PPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 420
Score = 42.0 bits (97), Expect = 5e-04
Identities = 40/195 (20%), Positives = 79/195 (40%), Gaps = 19/195 (9%)
Query: 41 PREAKNKRRSG----KNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAA 96
P K+ R G +++ S S + K+ S S + + R++ ++
Sbjct: 179 PESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSP 238
Query: 97 SKAASKQREML-------MEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSS 149
K SK RE D + ++ +++ +EKD + + E + + + G +
Sbjct: 239 HKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKN 298
Query: 150 KKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEED 209
K ++K+ +K + + KEK + R K K + K K + + KE D
Sbjct: 299 KDRDKER-EKDREKDKEKDREREREK-----EHEKDRDKEKEKEQDKEKEREKDRSKEID 352
Query: 210 EEPESPPEKKTSTSP 224
E+ + +KK+ T P
Sbjct: 353 EKRKK--DKKSRTPP 365
Score = 34.3 bits (77), Expect = 0.10
Identities = 27/163 (16%), Positives = 65/163 (39%), Gaps = 14/163 (8%)
Query: 17 QESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDS--- 73
+ D ++D +D +K R+ + ++ K + + + S++ D K KKD
Sbjct: 304 EREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRT 363
Query: 74 -----HSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEK 128
+++ S + + R + + S SK + S + ++D+ +E+
Sbjct: 364 PPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKER 423
Query: 129 DSGSDE------DFLMEDDDDSDYGSSKKKNKKMVKKSKPERK 165
D S+ + + +D D +KN +K+ + ++
Sbjct: 424 DHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKE 466
Score = 33.9 bits (76), Expect = 0.13
Identities = 29/147 (19%), Positives = 64/147 (43%), Gaps = 17/147 (11%)
Query: 17 QESDDADEDYGRDSGPP-----TKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKD 71
+E D+ + + PP +++ RSS RE +RR ++S S+ K+ +
Sbjct: 349 KEIDEKRKKDKKSRTPPRSYNASRRSRSSSRE--RRRRRSRSSSRSPRTSKTIKRKSSRS 406
Query: 72 DSHSAEDSEDEK----EDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQE 127
S + + +D+K DH + R++R+ ++ + +E+ E++ +E
Sbjct: 407 PSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDR------DGKEKLEKNSTSLKE 460
Query: 128 KDSGSDEDFLMEDDDDSDYGSSKKKNK 154
K+ + D + + D ++NK
Sbjct: 461 KEHNKEPDSSVSKEVDDKDAPRTEENK 487
Score = 33.5 bits (75), Expect = 0.17
Identities = 36/178 (20%), Positives = 69/178 (38%), Gaps = 18/178 (10%)
Query: 83 KEDHKN--VRQQRQAASKAASKQREMLMEDVGSEEE----QEEEDEAPFQEKDSGSDEDF 136
K +H N + + + +AA+K+ E +M+ V + E + E+ G
Sbjct: 136 KINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSH 195
Query: 137 LMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASK 196
S S++K + +S+ + + K R ++ +P + K + R + S+
Sbjct: 196 TRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSK-SPHKKRSKSRERRKSRSR 254
Query: 197 A--------SKEKTPSP---KEEDEEPESPPEKKTSTSPPPEKSGDEGSEDEAPSGED 243
+ ++EK KE+D E E EK+ K+ D E E +D
Sbjct: 255 SHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKD 312
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 60.8 bits (146), Expect = 1e-09
Identities = 47/199 (23%), Positives = 89/199 (44%), Gaps = 33/199 (16%)
Query: 53 NSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVG 112
NS ++ E+ E+++ + ++++ ED E+E+ED + ++ + E+
Sbjct: 884 NSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEE------------EEEF 931
Query: 113 SEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKP 172
EE +EEE E +E++ +E+ +E+ +D ++G++ + ++ P +P P
Sbjct: 932 EEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEE--GAPPPPTLPPALPPP 989
Query: 173 RLKATVTPSPVKGKGKV------------GRPTASKASKEKTPSPKEEDEEPESPPEKKT 220
V P P G + G TA + E PS E + E ESP
Sbjct: 990 ESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESP----- 1044
Query: 221 STSPPPEKSGDEGSEDEAP 239
+ PPP++ +E E AP
Sbjct: 1045 AAGPPPQELVEE--EPSAP 1061
Score = 28.5 bits (62), Expect = 5.5
Identities = 28/104 (26%), Positives = 37/104 (35%), Gaps = 21/104 (20%)
Query: 127 EKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGK 186
+K+ SD + +E D D PE P P AT P P+
Sbjct: 769 DKEEASDVEISLESDSDDSV------------VIVPEGLPPLPPPPPSGAT--PPPI--- 811
Query: 187 GKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSG 230
G PTAS P+ +E +E P +P PPP G
Sbjct: 812 APTGPPTASPP----VPAKEEPEELPAAPGPLPPPPPPPPPVPG 851
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 60.5 bits (145), Expect = 1e-09
Identities = 50/221 (22%), Positives = 86/221 (38%), Gaps = 14/221 (6%)
Query: 4 PVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSED 63
P++ + + ++ + P K++ P++A+ ++ E+ +DS
Sbjct: 802 PLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDS-- 859
Query: 64 KDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEA 123
KK+++ E + + E+ K ++ SK +K+ E ED E+E A
Sbjct: 860 -----KKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEA--EDKKKVPTPEKEAPA 912
Query: 124 PFQEKDSGSDEDFL----MEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVT 179
+ K+ ++ E DD SK KK K + KE+K KP K T
Sbjct: 913 KVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPK-T 971
Query: 180 PSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKT 220
+ K K SK EK D++ PPEK T
Sbjct: 972 EAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKAT 1012
Score = 57.0 bits (136), Expect = 1e-08
Identities = 54/217 (24%), Positives = 94/217 (43%), Gaps = 13/217 (5%)
Query: 17 QESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKT--KKDDSH 74
+E +A E+ G++ ++ EA+ K+ + S +K+ K+ K++
Sbjct: 473 EEEKEAKEEEGKEEEGGEEE------EAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKS 526
Query: 75 SAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDE 134
AE EKE+ K+ + + + KA S +E ++ ++EE ++P + K +
Sbjct: 527 PAEAKSPEKEEAKSPAEVK-SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAK 585
Query: 135 DFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTA 194
E+ S +K K VK+ E K P + +P+ VK K PT
Sbjct: 586 SPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVK--EEAKSPAEVKSPEKAKSPTK 643
Query: 195 SKA-SKEKTPSP-KEEDEEPESPPEKKTSTSPPPEKS 229
+A S EK SP KEE + PE + + PEK+
Sbjct: 644 EEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKA 680
Score = 55.8 bits (133), Expect = 3e-08
Identities = 61/243 (25%), Positives = 98/243 (40%), Gaps = 39/243 (16%)
Query: 18 ESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKT--------- 68
E ++A+ PP ++ S +EAK+ + S +++ E ++ K+
Sbjct: 490 EEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEK 549
Query: 69 -----KKDDSHSAEDSEDEKEDHKNVRQ-----------QRQAASKAASKQREMLMEDVG 112
K++ E EKE+ K+ + + +A S A +K E V
Sbjct: 550 AKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVK 609
Query: 113 SEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMP-- 170
E + E ++P +E+ E + +K++ K K PE++E K P
Sbjct: 610 EEAKSPAEAKSPVKEEAKSPAE----VKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEK 665
Query: 171 -KPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSP-KEEDEEPE--SPPEKKTSTSPPP 226
K +KA SP K K V A S EK SP KEE + PE P K+ + SP
Sbjct: 666 AKSPVKAE-AKSPEKAKSPV---KAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEK 721
Query: 227 EKS 229
KS
Sbjct: 722 AKS 724
Score = 54.7 bits (130), Expect = 7e-08
Identities = 52/217 (23%), Positives = 95/217 (43%), Gaps = 24/217 (11%)
Query: 33 PTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQ 92
P K+ SP E K+ ++ ++E+++ S +K +K+++ S E ++ + ++
Sbjct: 621 PVKEEAKSPAEVKSPEKAKSPTKEEAK-SPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK 679
Query: 93 RQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKK 152
++ KA +K E V E + E+ ++P +E+ ++ S K+
Sbjct: 680 AKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEK-----------AKSPVKE 728
Query: 153 NKKMVKKSK-PERKEKKMPKPRLKATVTPSPVKGKG-KVGRPTASKASKEKTPSPKEEDE 210
K +K+K P ++E K P+ SP K K V P A +KE+ SP ++
Sbjct: 729 EAKTPEKAKSPVKEEAKSPEK------AKSPEKAKTLDVKSPEAKTPAKEEARSPADKFP 782
Query: 211 EPESPPEKKTSTSP----PPEKSGDEGSEDEAPSGED 243
E P K+ SP P K + E E P E+
Sbjct: 783 EKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEE 819
Score = 53.5 bits (127), Expect = 2e-07
Identities = 54/224 (24%), Positives = 90/224 (40%), Gaps = 29/224 (12%)
Query: 35 KKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQ 94
K + S +E + +Q E +E+++ + K+++ E E+E+ + +
Sbjct: 445 KVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSP 504
Query: 95 AASKAASKQREM---LMEDVGSEEE----QEEEDEAPFQEKDSGSDEDFLMEDDDDSDYG 147
A +AAS ++E + E+ S E ++EE ++P + K + E+
Sbjct: 505 PAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA 564
Query: 148 SSKKKN--------KKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGK----------- 188
S +K K K P ++E K P SPVK + K
Sbjct: 565 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE 624
Query: 189 VGRPTASKASKEKTPSP-KEEDEEPE--SPPEKKTSTSPPPEKS 229
+ A S EK SP KEE + PE PEK+ + SP KS
Sbjct: 625 EAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKS 668
Score = 51.2 bits (121), Expect = 8e-07
Identities = 61/256 (23%), Positives = 96/256 (37%), Gaps = 45/256 (17%)
Query: 28 RDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHK 87
+++ P K+ SP EAK+ + S + + E K++ E EKE+ K
Sbjct: 514 KEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAK 573
Query: 88 NVRQ-----------QRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDF 136
+ + + +A S A +K E V E + E ++P +E+ E
Sbjct: 574 SPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAE-- 631
Query: 137 LMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMP-----------------KPRLKATV- 178
+ +K++ K K PE++E K P K +KA
Sbjct: 632 --VKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAK 689
Query: 179 ----TPSPVKGKGKVGRPTASKA-----SKEKTPSP-KEEDEEPE--SPPEKKTSTSPPP 226
SPVK + K S S EK SP KEE + PE P K+ + SP
Sbjct: 690 SPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEK 749
Query: 227 EKSGDEGSEDEAPSGE 242
KS ++ + S E
Sbjct: 750 AKSPEKAKTLDVKSPE 765
Score = 49.7 bits (117), Expect = 2e-06
Identities = 52/214 (24%), Positives = 92/214 (42%), Gaps = 19/214 (8%)
Query: 44 AKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAAS--KAAS 101
AK + RS + + S K+ + K + + ED K K + ++ + S K
Sbjct: 770 AKEEARSPADKFPEKAKSPVKE-EVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEE 828
Query: 102 KQREMLMEDVGSEEEQEEEDEAPFQE--KDSGSDEDFLMED-----DDDSDYGSSKKKNK 154
K +E+ +++ + E+E+ P E KDS +E E ++ + K K
Sbjct: 829 KPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKES 888
Query: 155 KMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKE-----KTPSPKEED 209
K+ K + +KK+P P +A P+ V+ K ++ +K+ K P +
Sbjct: 889 KVEAKKEEAEDKKKVPTPEKEA---PAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPA 945
Query: 210 EEPESPPEKKTSTSPPPEKSGDEGSEDEAPSGED 243
E+ E+ PEKK T K +E + EA + ED
Sbjct: 946 EKKEAAPEKK-DTKEEKAKKPEEKPKTEAKAKED 978
Score = 49.3 bits (116), Expect = 3e-06
Identities = 48/182 (26%), Positives = 77/182 (42%), Gaps = 25/182 (13%)
Query: 66 VKTKKDDSHSA-EDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAP 124
+K K ++ E SE E + ++ Q + ++ + E+ G EEE EE+EA
Sbjct: 436 IKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAE 495
Query: 125 FQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVK 184
E+++ S + S +K+ K VK+ E K P+ + +P+ VK
Sbjct: 496 GGEEETKSPPA--------EEAASPEKEAKSPVKEEAKSPAEAKSPEK--EEAKSPAEVK 545
Query: 185 GKGKVGRPTASKASKEKTPSPKE----EDEEPESPPEKKTSTSPPPEKSGDEGSEDEAPS 240
K P +KE+ SP E E EE +SP E K+ PEK+ E+
Sbjct: 546 SPEKAKSP-----AKEEAKSPPEAKSPEKEEAKSPAEVKS-----PEKAKSPAKEEAKSP 595
Query: 241 GE 242
E
Sbjct: 596 AE 597
Score = 46.6 bits (109), Expect = 2e-05
Identities = 40/164 (24%), Positives = 79/164 (48%), Gaps = 13/164 (7%)
Query: 86 HKNVRQQRQAASKAASKQREMLMEDVGSE----EEQEEEDEAPFQEKDSGSDEDFLMEDD 141
H V+ + + S++ +++E+ E EE EE+E +E++ +E ++
Sbjct: 435 HIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEG---GEE 491
Query: 142 DDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATV-TPSPVKGKGKVGRPTASKASKE 200
++++ G + K+ + + PE++ K K K+ SP K + K S K
Sbjct: 492 EEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSP-EKA 550
Query: 201 KTPSPKEEDEEPES-PPEKKTSTSPPPEKSGDEG---SEDEAPS 240
K+P+ +E PE+ PEK+ + SP KS ++ +++EA S
Sbjct: 551 KSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKS 594
Score = 42.7 bits (99), Expect = 3e-04
Identities = 44/205 (21%), Positives = 84/205 (40%), Gaps = 14/205 (6%)
Query: 4 PVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSED 63
PV+ + + +E E+ + P T++ + S +E K+ + K E E
Sbjct: 823 PVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVE-----EK 877
Query: 64 KDVKTKKDDSHSAEDSEDEKEDHKNV-RQQRQAASKAASKQREMLMEDVGSEEEQEEEDE 122
K+ +K E ++E ED K V +++A +K K+ E +E ++E D+
Sbjct: 878 KEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEK--TEVAKKEPDD 935
Query: 123 APFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPER------KEKKMPKPRLKA 176
A +E +++ + D+ +KK +K ++K + KE PK
Sbjct: 936 AKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAE 995
Query: 177 TVTPSPVKGKGKVGRPTASKASKEK 201
+ + K + T KA+K K
Sbjct: 996 KSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 30.4 bits (67), Expect = 1.5
Identities = 21/87 (24%), Positives = 37/87 (42%), Gaps = 2/87 (2%)
Query: 159 KSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEED--EEPESPP 216
K K E K K + K + + + T + + K KEE+ EE E+
Sbjct: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEG 496
Query: 217 EKKTSTSPPPEKSGDEGSEDEAPSGED 243
++ + SPP E++ E ++P E+
Sbjct: 497 GEEETKSPPAEEAASPEKEAKSPVKEE 523
>gi|223941846 zinc finger protein 652 [Homo sapiens]
Length = 606
Score = 59.7 bits (143), Expect = 2e-09
Identities = 54/207 (26%), Positives = 96/207 (46%), Gaps = 13/207 (6%)
Query: 17 QESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSA 76
QE D + + Y R+SG P + + + +K + E DV K+D ++
Sbjct: 42 QELDLSTKVYKRESGSPYSVLVDT-KMSKPHLHETEEQPYFRETRAVSDVHAVKEDRENS 100
Query: 77 EDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDF 136
+D+E+E+E+ V +R+ + + L G + + E P + S +E+
Sbjct: 101 DDTEEEEEE---VSYKREQIIVEVNLNNQTLNVSKGEKGVSSQSKETPVLKTSSEEEEEE 157
Query: 137 LMED--DDDSDYGSSKKKNK--KMVKKSKPERKEKKMPKPRLKATVTPSP--VKGKGKVG 190
E+ DD +DYG ++K+ K K+V+K ++ + AT +P+P +G+ K
Sbjct: 158 SEEEATDDSNDYGENEKQKKKEKIVEKVSVTQRRTRRAASVAAATTSPTPRTTRGRRKSV 217
Query: 191 RPTASK--ASKE-KTPSPKEEDEEPES 214
P K A+KE K P K + EE E+
Sbjct: 218 EPPKRKKRATKEPKAPVQKAKCEEKET 244
>gi|7662384 zinc finger protein 652 [Homo sapiens]
Length = 606
Score = 59.7 bits (143), Expect = 2e-09
Identities = 54/207 (26%), Positives = 96/207 (46%), Gaps = 13/207 (6%)
Query: 17 QESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSA 76
QE D + + Y R+SG P + + + +K + E DV K+D ++
Sbjct: 42 QELDLSTKVYKRESGSPYSVLVDT-KMSKPHLHETEEQPYFRETRAVSDVHAVKEDRENS 100
Query: 77 EDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDF 136
+D+E+E+E+ V +R+ + + L G + + E P + S +E+
Sbjct: 101 DDTEEEEEE---VSYKREQIIVEVNLNNQTLNVSKGEKGVSSQSKETPVLKTSSEEEEEE 157
Query: 137 LMED--DDDSDYGSSKKKNK--KMVKKSKPERKEKKMPKPRLKATVTPSP--VKGKGKVG 190
E+ DD +DYG ++K+ K K+V+K ++ + AT +P+P +G+ K
Sbjct: 158 SEEEATDDSNDYGENEKQKKKEKIVEKVSVTQRRTRRAASVAAATTSPTPRTTRGRRKSV 217
Query: 191 RPTASK--ASKE-KTPSPKEEDEEPES 214
P K A+KE K P K + EE E+
Sbjct: 218 EPPKRKKRATKEPKAPVQKAKCEEKET 244
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 59.3 bits (142), Expect = 3e-09
Identities = 61/261 (23%), Positives = 102/261 (39%), Gaps = 50/261 (19%)
Query: 19 SDDADEDYGRDSGPPTKKIRSSPREAKNKRRSG-------KNSQED------SEDSEDKD 65
SD D+ + SG T + + R G +S+ D + DSE ++
Sbjct: 27 SDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEE 86
Query: 66 VKTKKD-DSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEE-------EQ 117
+ +KD DS S E +E D +N + + + + R++ D +EE +
Sbjct: 87 LHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDS 146
Query: 118 EEEDEAPFQEKDS------------GSDEDFLMEDDDDSD------YGSSKKKNKKMVKK 159
E ED DS ED L DS+ + +S +N++ K
Sbjct: 147 ENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKP 206
Query: 160 SKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKK 219
+ + +++PKP++ + + P R AS + E+ P P+ D E E PP +
Sbjct: 207 RMSDSESEELPKPQVSDSESEEP-------PRHQASDSENEELPKPRISDSESEDPPRHQ 259
Query: 220 TSTSP----PPEKSGDEGSED 236
S S P + D SED
Sbjct: 260 ASDSENEELPKPRISDSESED 280
Score = 57.4 bits (137), Expect = 1e-08
Identities = 55/232 (23%), Positives = 95/232 (40%), Gaps = 37/232 (15%)
Query: 39 SSPREAKNKRRSGKNSQEDSE----DSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQ 94
S E ++ S S+E +E DSE++DV DS S E + D +N +
Sbjct: 82 SESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSEN---EEL 138
Query: 95 AASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSD------YGS 148
A+ + E + + S+ E EE ++P + ++ ED L DS+ + +
Sbjct: 139 LNGHASDSENEDVGKHPASDSEIEELQKSPASDSET---EDALKPQISDSESEEPPRHQA 195
Query: 149 SKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVG------------------ 190
S +N++ K + + +++PKP++ + + P + +
Sbjct: 196 SDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDP 255
Query: 191 -RPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPE--KSGDEGSEDEAP 239
R AS + E+ P P+ D E E PP + S S E K SE E P
Sbjct: 256 PRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGP 307
Score = 41.6 bits (96), Expect = 6e-04
Identities = 34/172 (19%), Positives = 70/172 (40%), Gaps = 19/172 (11%)
Query: 4 PVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSED 63
P + + D S+ ++ ++D+D R++ ++++ + + K DSE+ E
Sbjct: 311 PASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEH 370
Query: 64 KDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAA-------SKAASKQREMLMEDVGSEEE 116
K K D EDEKE + +R+AA + AS ++ ++ D +
Sbjct: 371 KKQKMDSD--------EDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDS 422
Query: 117 QEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKK 168
D++ +EK SD E++ + K + K + E++
Sbjct: 423 DAVSDKSGKREKTIASDS----EEEAGKELSDKKNEEKDLFGSDSESGNEEE 470
Score = 40.8 bits (94), Expect = 0.001
Identities = 40/208 (19%), Positives = 74/208 (35%), Gaps = 39/208 (18%)
Query: 4 PVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSED 63
P + + D + Q SD E+ PP + S E K R + E+ +
Sbjct: 168 PASDSETEDALKPQISDSESEE------PPRHQASDSENEEPPKPRMSDSESEELPKPQV 221
Query: 64 KDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEA 123
D ++++ H A DSE+E+ + + E ED
Sbjct: 222 SDSESEEPPRHQASDSENEELPKPRI-------------------------SDSESEDPP 256
Query: 124 PFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPV 183
Q DS E+++ S +++ + + + +++PKPR+ + + P
Sbjct: 257 RHQASDS--------ENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQ 308
Query: 184 KGKGKVGRPTASKASKEKTPSPKEEDEE 211
KG + K+K S + D E
Sbjct: 309 KGPASDSETEDASRHKQKPESDDDSDRE 336
Score = 40.8 bits (94), Expect = 0.001
Identities = 32/132 (24%), Positives = 63/132 (47%), Gaps = 13/132 (9%)
Query: 11 VDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKK 70
+D +F SD +E++ + + + E KR++ S DSED E K +
Sbjct: 355 MDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLS--DSEDEEKASAKKSR 412
Query: 71 DDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSE--EEQEEEDEAPFQEK 128
S A+DS+ + K+ ++++ AS + E+ G E +++ EE + +
Sbjct: 413 VVS-DADDSDSDAVSDKSGKREKTIASDSE--------EEAGKELSDKKNEEKDLFGSDS 463
Query: 129 DSGSDEDFLMED 140
+SG++E+ L+ D
Sbjct: 464 ESGNEEENLIAD 475
Score = 38.5 bits (88), Expect = 0.005
Identities = 43/179 (24%), Positives = 72/179 (40%), Gaps = 26/179 (14%)
Query: 12 DYSQFQESDDADEDYGRDSGPPTKKIR----SSPREAKNKRRSGKNSQEDSEDSEDKDVK 67
++ + + D DE G + +K S E + ++S S D DS+ K
Sbjct: 369 EHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDK 428
Query: 68 TKKDDSHSAEDSEDEK----EDHKNVRQQRQAASKAASKQREMLMEDV-----GSEEE-- 116
+ K + A DSE+E D KN + + + + E L+ D+ EEE
Sbjct: 429 SGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEF 488
Query: 117 --------QEEEDEAPFQE-KDSGSDEDFLMEDDDD--SDYGSSKKKNKKMVKKSKPER 164
+EE+ E +E +DS SD++ D SD+ ++ K M K + R
Sbjct: 489 TGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNR 547
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 58.9 bits (141), Expect = 4e-09
Identities = 51/225 (22%), Positives = 89/225 (39%), Gaps = 23/225 (10%)
Query: 18 ESDDADEDYGRDSGPPTKKIRSSP-REAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSA 76
E D+ D + +++G P + P R+ + + GK+ + + DSE ++ +
Sbjct: 919 EEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDE 978
Query: 77 EDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQ-----EKDSG 131
ED E+++ED + R+ A K+ E+ G +EE + + E DS
Sbjct: 979 EDDEEDEED-----EDREEAVDTTKKETEV---SDGEDEESDSSSKCSLYADSDGENDST 1030
Query: 132 SDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPS----PVKGKG 187
SD + S SS + E++ +P + +P PV
Sbjct: 1031 SDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPA 1090
Query: 188 KVGRPTASK-ASKEKTPSPKEE--DEEPESPPEKKTSTSP--PPE 227
V P + A TP P++E P P E+ ++P PPE
Sbjct: 1091 PVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPE 1135
Score = 57.8 bits (138), Expect = 9e-09
Identities = 54/227 (23%), Positives = 81/227 (35%), Gaps = 28/227 (12%)
Query: 23 DEDYGRDSGPPTKK--IRSSPREAKNKRRSGKNSQEDSEDSEDKD----VKTKKDDSHSA 76
DE+ G+ G K + S EA + S K+ ++D ED ED+D V T K ++
Sbjct: 945 DEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKET-EV 1003
Query: 77 EDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDF 136
D EDE+ D S + L D E + + E+ S S
Sbjct: 1004 SDGEDEESD---------------SSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSS- 1047
Query: 137 LMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVK---GKGKVGRPT 193
S SS+ ++ ++ +P P PR TP+PV+ + G P
Sbjct: 1048 --SSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPV 1105
Query: 194 ASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGSEDEAPS 240
+E +P+ E P PP DE PS
Sbjct: 1106 TPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPS 1152
Score = 51.6 bits (122), Expect = 6e-07
Identities = 52/191 (27%), Positives = 76/191 (39%), Gaps = 19/191 (9%)
Query: 52 KNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDV 111
K E SE SE+K + S AE+ ED+ E K + + +K + E +
Sbjct: 898 KEPSEISEASEEK----RPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEER-GKTQ 952
Query: 112 GSEEEQ---EEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEK- 167
G + + E E QE S DE+ ED++D D + KK + S E +E
Sbjct: 953 GKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESD 1012
Query: 168 KMPKPRLKA-------TVTPSPVKGKGKVGRPTASKASKEKTPSPKE---EDEEPESPPE 217
K L A + + S ++S +S + S E EDEE E P
Sbjct: 1013 SSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPA 1072
Query: 218 KKTSTSPPPEK 228
S SPPP +
Sbjct: 1073 ALPSASPPPRE 1083
Score = 38.1 bits (87), Expect = 0.007
Identities = 50/215 (23%), Positives = 77/215 (35%), Gaps = 20/215 (9%)
Query: 9 KVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKT 68
+ VD ++ + ED DS S E + S +S S S +
Sbjct: 992 EAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSS 1051
Query: 69 KKDDSHSAEDSEDEKEDHKNVRQQRQAASKAAS-KQREMLMEDVGSEEEQEEEDEAPFQE 127
S S SEDE+E ++R AA +AS RE+ + E P E
Sbjct: 1052 SSSSSSSESSSEDEEE------EERPAALPSASPPPREVPVPTPAPV-------EVPVPE 1098
Query: 128 KDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPS---PVK 184
+ +GS L E + + + +P P P + PS P+
Sbjct: 1099 RVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLL 1158
Query: 185 GKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKK 219
K R T S ++ E P+P + P +PP+ K
Sbjct: 1159 PPPKKRRKTVSFSAIEVVPAP---EPPPATPPQAK 1190
Score = 30.0 bits (66), Expect = 1.9
Identities = 15/43 (34%), Positives = 19/43 (44%)
Query: 195 SKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGSEDE 237
S+AS+EK P P EE E PE++ P DE
Sbjct: 904 SEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDE 946
Score = 28.9 bits (63), Expect = 4.2
Identities = 32/111 (28%), Positives = 48/111 (43%), Gaps = 12/111 (10%)
Query: 143 DSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPV---KGKGKVGRPTASKAS- 198
D + S ++K K +K + KE+ K +LK S V K G G + S
Sbjct: 824 DQWWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSG 883
Query: 199 ---KEKTPSPKEEDEEP----ESPPEKKTSTSPPPEKSGDEGSEDEAPSGE 242
+ PS K + +EP E+ EK+ S P E+ D+ E E +GE
Sbjct: 884 LRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDD-PEQEKEAGE 933
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 58.5 bits (140), Expect = 5e-09
Identities = 60/274 (21%), Positives = 111/274 (40%), Gaps = 49/274 (17%)
Query: 17 QESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSA 76
+ S D ++D R + R RE + +R + + + E +++ + +++
Sbjct: 372 ERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKR 431
Query: 77 EDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGS--------EEEQEEEDEAPFQEK 128
+ EDE++ ++ + +R+ K A+ Q + ++ +E + EE+ K
Sbjct: 432 DREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAK 491
Query: 129 DSGSDEDFLMEDDDDSD-----YGSSKKKNKKMVKKS--------KPERKEKKMPKPRLK 175
++ ++FL + DDD D GS+ +K + +K K E++E + + RL
Sbjct: 492 EAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLL 551
Query: 176 ATVTPSP------------------VKGKGKVGRPTASKASKE-KTPSPKEEDEEPESPP 216
A P P +K + + K KE K P EE+EEPE P
Sbjct: 552 AEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKP 611
Query: 217 EKKTSTSP---PPEKSGDEGSE------DEAPSG 241
K + P P S G+ DE+P G
Sbjct: 612 CLKPTLRPISSAPSVSSASGNATPNTPGDESPCG 645
Score = 48.5 bits (114), Expect = 5e-06
Identities = 36/199 (18%), Positives = 79/199 (39%)
Query: 17 QESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSA 76
+E + E R+ ++ R +E + +R ++ D D+D ++D
Sbjct: 312 RERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDR 371
Query: 77 EDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDF 136
E S D +D R++ + + ++RE E E + E + +E++ D+
Sbjct: 372 ERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKR 431
Query: 137 LMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASK 196
E+D++ Y K + K K++ + + K K T + + R +K
Sbjct: 432 DREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAK 491
Query: 197 ASKEKTPSPKEEDEEPESP 215
+K ++ D++ + P
Sbjct: 492 EAKRLKEFLEDYDDDRDDP 510
Score = 42.4 bits (98), Expect = 4e-04
Identities = 42/223 (18%), Positives = 89/223 (39%), Gaps = 37/223 (16%)
Query: 25 DYGRDSGPPTKKIRSSPREAKNKRR-----------------------SGKNSQEDSEDS 61
+Y + P+++ S PR+ K +++ + +ED D
Sbjct: 217 EYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDL 276
Query: 62 EDKDVKTKKDDSHSAEDSEDEKE-DHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEE 120
+++ +D E+ + +KE + + + ++R+ + ++RE + E E+E E
Sbjct: 277 ISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERERERE 336
Query: 121 DEAPFQ---------EKDSGSDEDFLMEDDDDSDYGSSKKKNK---KMVKKSKPERKEKK 168
E + ++ D D E D D D S +NK + +KS+ +E++
Sbjct: 337 KEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERE 396
Query: 169 MPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEE 211
+ R + + + + R + K+K +EEDEE
Sbjct: 397 REREREREREREREREREREREREREREREKDK-KRDREEDEE 438
Score = 37.4 bits (85), Expect = 0.012
Identities = 42/230 (18%), Positives = 94/230 (40%), Gaps = 31/230 (13%)
Query: 8 RKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVK 67
+++ ++ + + D D Y R S K++R +E + R K +E+ E+ + +
Sbjct: 494 KRLKEFLEDYDDDRDDPKYYRGSALQ-KRLRDREKEMEADERDRKREKEELEEIRQRLL- 551
Query: 68 TKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQE 127
AE D + + + Q+ + + KQ E+ ++E+EE+ E P +E
Sbjct: 552 --------AEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEE 603
Query: 128 KDSGSDEDFL---MEDDDDSDYGSSKKKNKK-------------MVKKSKPERKEKKMPK 171
++ + L + + SS N + ++ P++++ + +
Sbjct: 604 EEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHR 663
Query: 172 PRLKATVTPSPVKGKGKVGRPTASKASKEKTPS--PKEEDEEPESPPEKK 219
P++ ++ + G+P + K K S K EDE+ + P K+
Sbjct: 664 PKIGLSL---KLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKR 710
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 58.5 bits (140), Expect = 5e-09
Identities = 47/231 (20%), Positives = 97/231 (41%), Gaps = 8/231 (3%)
Query: 6 RNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKD 65
R+R+ + + DA+++ R+ ++ R + R + +R KN QE E ++
Sbjct: 139 RDRQTDGQRERERQRDAEKE--RERQTDRERQRQTERNRQKEREREKNRQERRERERQRE 196
Query: 66 VKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPF 125
+ K +D HS E E+E +R+ + ++R+ + E+Q E + A
Sbjct: 197 KENKTEDRHSERGRERERERETETETERK---RQTDRERDRQRKTEREREKQAERERA-- 251
Query: 126 QEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKG 185
E+++ D++ E D D D +K+ ++ + + R E+ R + +
Sbjct: 252 SERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERER 311
Query: 186 KGKVGRPTASKASKEKTPSPK-EEDEEPESPPEKKTSTSPPPEKSGDEGSE 235
+ R + +E+ + E D E E ++K T E++ G E
Sbjct: 312 ERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGRE 362
Score = 47.0 bits (110), Expect = 2e-05
Identities = 46/233 (19%), Positives = 96/233 (41%), Gaps = 13/233 (5%)
Query: 17 QESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSA 76
Q DAD D D +K R RE KR++ + + E +KD K+D
Sbjct: 44 QAHKDADGD---DRERNRQKERERRRE---KRQTERETDRKRERRREKDRHRKRDRHRER 97
Query: 77 E-DSEDEKE---DHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGS 132
+ D E E+E D + RQ+ + ++ ++RE E + Q + +++D+
Sbjct: 98 QRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEK 157
Query: 133 DEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRP 192
+ + + + +++K ++ +K++ ER+E++ + + T +G+ +
Sbjct: 158 ERERQTDRERQRQTERNRQKERER-EKNRQERRERERQREKENKTEDRHSERGRERERER 216
Query: 193 TASKASKEKTPSPKEEDEE--PESPPEKKTSTSPPPEKSGDEGSEDEAPSGED 243
++ K + +E D + E EK+ E+ + E E D
Sbjct: 217 ETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRD 269
Score = 44.3 bits (103), Expect = 1e-04
Identities = 39/230 (16%), Positives = 94/230 (40%), Gaps = 14/230 (6%)
Query: 15 QFQESDDADEDYGRDSGPPTKKIRSSPREA-KNKRRSGKNSQEDSEDSEDKDVKTKKDDS 73
Q D R+ ++ R+S RE ++K R + ++ D K+ + + D
Sbjct: 227 QTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRK 286
Query: 74 HSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSD 133
D + + K RQ+ + + +++RE E E E+E + E E+D +
Sbjct: 287 RQRRTERDRETERKRERQRERERERERNRKRERERE---RERERERQRET---ERDREKE 340
Query: 134 EDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPT 193
+ + + D +++ ++ ++++ ER E++ + R A + + +
Sbjct: 341 RERKRKRQTEMDRERNRQTGREGRRQAERER-ERERERDRQSAREREERERDRDR----- 394
Query: 194 ASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGSEDEAPSGED 243
+ + + + K+ D + E+ +++ E+ + G E E G +
Sbjct: 395 -DRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRE 443
Score = 43.9 bits (102), Expect = 1e-04
Identities = 31/186 (16%), Positives = 77/186 (41%), Gaps = 4/186 (2%)
Query: 38 RSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKE-DHKNVRQQRQAA 96
R P ++ RR G D +D++ +K+ E + E+E D K R++ +
Sbjct: 28 RRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDR 87
Query: 97 SKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKK---KN 153
+ + RE + E Q + + +EK+ ++ E + + + G ++ +
Sbjct: 88 HRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQR 147
Query: 154 KKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPE 213
++ ++ + +E++ + R + T + + + R + +++ K ED E
Sbjct: 148 ERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSE 207
Query: 214 SPPEKK 219
E++
Sbjct: 208 RGRERE 213
Score = 41.2 bits (95), Expect = 8e-04
Identities = 35/217 (16%), Positives = 83/217 (38%), Gaps = 19/217 (8%)
Query: 15 QFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSH 74
Q + D + R+ K+ R R+ ++ + + + + +K+ +K+
Sbjct: 70 QTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERER 129
Query: 75 SAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDE 134
E + D + Q+ + + A K+RE + + Q E + +E++ E
Sbjct: 130 ETEREGERGRDRQTDGQRERERQRDAEKERERQTD--RERQRQTERNRQKEREREKNRQE 187
Query: 135 DFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTA 194
+++ ++ K++K E + + + R + T + + K + R
Sbjct: 188 --------------RRERERQREKENKTEDRHSERGRERERERETETETERKRQTDR--- 230
Query: 195 SKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGD 231
+ + KT +E+ E E E++T E+ D
Sbjct: 231 ERDRQRKTEREREKQAERERASERETERDKERERERD 267
Score = 40.0 bits (92), Expect = 0.002
Identities = 50/236 (21%), Positives = 93/236 (39%), Gaps = 28/236 (11%)
Query: 21 DADEDYGRDSGPPTKKIRSSPREAKNKR-------RSGKNSQEDSEDSEDKDVKTKKDDS 73
+ + + R+ T++ R RE K KR R+ + +E +E + + ++ D
Sbjct: 320 ERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDR 379
Query: 74 HSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSD 133
SA + E+ + D RQ K+RE E + Q E ++ +EKD S+
Sbjct: 380 QSAREREERERDRDRDRQ----------KERERQTEK--DRDGQRETEKQREREKDRESE 427
Query: 134 EDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKM---PKPR-LKATVTPS----PVKG 185
+ + G + + ++ +++ +RK + P PR ++ V S P +G
Sbjct: 428 RGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRG 487
Query: 186 KGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGSEDEAPSG 241
P KA+ + P + ++ EK G +G E PSG
Sbjct: 488 IRWKSSPEDPKAASTRFPWGRPAKASRGRVAGRRRWEPRLGEKRG-QGGEGRRPSG 542
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 57.8 bits (138), Expect = 9e-09
Identities = 39/139 (28%), Positives = 66/139 (47%), Gaps = 7/139 (5%)
Query: 29 DSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSE------DKDVKTKKDDSHSAEDSEDE 82
+SG K +E K + R K S EDSEDS+ ++V +D+ S +
Sbjct: 1313 ESGEEKKTKPKEHKEVKGRNRR-KVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKK 1371
Query: 83 KEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDD 142
E +N R +Q + K +E + S E+EEE++ +E++ +E+ E+DD
Sbjct: 1372 AELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDD 1431
Query: 143 DSDYGSSKKKNKKMVKKSK 161
G +KK +K++K K
Sbjct: 1432 SKSPGKGRKKIRKILKDDK 1450
Score = 51.6 bits (122), Expect = 6e-07
Identities = 45/217 (20%), Positives = 89/217 (41%), Gaps = 27/217 (12%)
Query: 22 ADEDYGRDSGPPTKKIRSSPREAKN----KRRSGKNSQEDSEDSEDKDVKTKK------- 70
+DED D P K R+ + +N + ++ NS+ DS+ E K + +
Sbjct: 1248 SDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKL 1307
Query: 71 --DDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDE------ 122
D S E+ + + ++HK V+ + + + + E SEE E EDE
Sbjct: 1308 TVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTR 1367
Query: 123 ----APFQEKDSGSDEDF----LMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRL 174
A +E + + +D S S + ++ K+ + E +E++ +
Sbjct: 1368 SAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEED 1427
Query: 175 KATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEE 211
+ + SP KG+ K+ + + +T + +E+EE
Sbjct: 1428 ENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEE 1464
Score = 42.7 bits (99), Expect = 3e-04
Identities = 62/248 (25%), Positives = 99/248 (39%), Gaps = 44/248 (17%)
Query: 32 PPTKKIRSSPREAKNKR-------RSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSED--- 81
P TK SS E +K+ ++ K SQE S D D + K +++ SAE + D
Sbjct: 804 PNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSD--DAERKQERETFSSAEGTVDKDT 861
Query: 82 ---EKEDHKNVRQQRQAAS----KAASKQREMLMEDVGSEEEQEEEDE-------APFQE 127
E D +QQ A++ K + K++ +V E +E+ + Q+
Sbjct: 862 TIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQD 921
Query: 128 KDSGSDEDFLMEDDDDSDYGSSKKKNKK-MVKKSKPERKEKKMPK--------------- 171
S E FL +D D KK++KK +K KP +KK+ K
Sbjct: 922 GLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKL 981
Query: 172 -PRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSG 230
R + P +K + K G K SK+ ++ +E EK T + S
Sbjct: 982 PEREEICHFPKGIK-QIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSE 1040
Query: 231 DEGSEDEA 238
D+ S++ A
Sbjct: 1041 DKKSKNGA 1048
Score = 42.7 bits (99), Expect = 3e-04
Identities = 42/179 (23%), Positives = 80/179 (44%), Gaps = 18/179 (10%)
Query: 6 RNRKVV-----DYSQFQESDDADE--DYGRDSGPPTKKIRSSPREA-------KNKRRSG 51
RNR+ V + S FQES ++E + + P T+ + + E K KRR
Sbjct: 1331 RNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRI 1390
Query: 52 KNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDV 111
K ++ S +++ + +++ E+ E+E+E+ ++ ++ K K R++L +D
Sbjct: 1391 KVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDK 1450
Query: 112 GSEEEQ---EEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSK-KKNKKMVKKSKPERKE 166
E Q +EE+E + + + + L E + D +K K+V E KE
Sbjct: 1451 LRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKE 1509
Score = 37.7 bits (86), Expect = 0.009
Identities = 56/249 (22%), Positives = 98/249 (39%), Gaps = 51/249 (20%)
Query: 18 ESDDADED-------YGRDS------GPPTKKIR---SSPREAKNKRRSGKNSQEDS--- 58
+S D+ ED YGR+ G ++K + SS E + + G NS +
Sbjct: 1034 DSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKR 1093
Query: 59 -EDSEDKDVKTKKDDSH-----SAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVG 112
E E +++ +K++ S+ D+E+ ED+K ++QR ++ K A +E +
Sbjct: 1094 IELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKK-KKQRTSSKKKAVIVKEKKRNSLR 1152
Query: 113 SEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKP 172
+ ++++ D D +EDDD + G +K+ KP
Sbjct: 1153 TSTKRKQADITSSSSSD--------IEDDDQNSIGEGSSDEQKI--------------KP 1190
Query: 173 RLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPE--KSG 230
+ V S G SK S T ++D +PE+ KK S
Sbjct: 1191 VTENLVLSSHTGFCQSSGDEALSK-SVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD 1249
Query: 231 DEGSEDEAP 239
++GS D+ P
Sbjct: 1250 EDGSSDDEP 1258
Score = 37.0 bits (84), Expect = 0.016
Identities = 54/253 (21%), Positives = 98/253 (38%), Gaps = 52/253 (20%)
Query: 1 MSRPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAK------NKRRSGKNS 54
+ RP V S +E ++ ++ + S P KK + + ++ NK K S
Sbjct: 626 LRRPTETNPVTSNSD-EECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQS 684
Query: 55 Q--EDSEDSED-----KDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREML 107
+ + + DS++ K+V S S D + +HK + + A K
Sbjct: 685 ETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGK--------- 735
Query: 108 MEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEK 167
+D+ + K S S DF D+ G S K+ + KK + + E
Sbjct: 736 ------------DDKGKRKRKSSTSGSDF------DTKKGKS-AKSSIISKKKRQTQSES 776
Query: 168 KMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPE 227
L+ +K K+G A++ +K++ P+ K+ D + KK + +
Sbjct: 777 SNYDSELE-----KEIKSMSKIG---AARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHK 828
Query: 228 --KSGDEGSEDEA 238
K+ EGS D+A
Sbjct: 829 NLKTSQEGSSDDA 841
Score = 35.8 bits (81), Expect = 0.035
Identities = 51/266 (19%), Positives = 100/266 (37%), Gaps = 59/266 (22%)
Query: 14 SQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDS 73
S +ES + ++ + + K + ++ + R S K Q D S D++ DD
Sbjct: 1118 SDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIED--DDQ 1175
Query: 74 HSAEDSEDEKEDHKNVRQQ----------RQAASKAASKQ-------------------R 104
+S + +++ K V + + + +A SK +
Sbjct: 1176 NSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAK 1235
Query: 105 EMLMEDV----GSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKS 160
+ML+E++ S+E+ +DE +K +G ++ + G + KN ++ +S
Sbjct: 1236 KMLLEEIKANLSSDEDGSSDDEPEEGKKRTGK--------QNEENPGDEEAKN-QVNSES 1286
Query: 161 KPERKEKKMPKPR---LKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPE 217
+ +E K P+ R L+ +T S ++ +EK PKE E
Sbjct: 1287 DSDSEESKKPRYRHRLLRHKLTVSD------------GESGEEKKTKPKEHKEVKGRNRR 1334
Query: 218 KKTSTSPPPEKSGDEGSEDEAPSGED 243
K +S + G +E ED
Sbjct: 1335 KVSSEDSEDSDFQESGVSEEVSESED 1360
Score = 32.3 bits (72), Expect = 0.38
Identities = 39/218 (17%), Positives = 81/218 (37%), Gaps = 20/218 (9%)
Query: 36 KIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKT----KKDDSHSAEDSEDEKEDHKNVRQ 91
K ++ + ++R S D + + K K+ KK +E S + E K ++
Sbjct: 730 KTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKS 789
Query: 92 QRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKK 151
+ + +K+R +D S E+++ + D+ ++ + SD K+
Sbjct: 790 MSKIGAARTTKKRIPNTKDFDSSEDEKHSKKG----MDNQGHKNLKTSQEGSSDDAERKQ 845
Query: 152 KNKKMVKKSKPERKE-------KKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPS 204
+ + K+ ++PK + + T K GK T+ + K
Sbjct: 846 ERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETK 905
Query: 205 PKEEDEEPESPPEKKTSTSPPPEK-----SGDEGSEDE 237
K + + ++ + + S EK DE SED+
Sbjct: 906 EKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDD 943
Score = 29.3 bits (64), Expect = 3.2
Identities = 39/177 (22%), Positives = 67/177 (37%), Gaps = 17/177 (9%)
Query: 40 SPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKA 99
S EAK R+ Q DSE ++V T++ ++ + E +K D K Q A +
Sbjct: 420 SKSEAKLSRK-----QVDSEHMH-QNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANT-- 471
Query: 100 ASKQREM--------LMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKK 151
S+ +M + ED+ E E ++ + GS + S K
Sbjct: 472 -SEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSK 530
Query: 152 KNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEE 208
N+ +K + K++ +++ SP+KG P K +PK E
Sbjct: 531 DNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLE 587
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 57.8 bits (138), Expect = 9e-09
Identities = 39/139 (28%), Positives = 66/139 (47%), Gaps = 7/139 (5%)
Query: 29 DSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSE------DKDVKTKKDDSHSAEDSEDE 82
+SG K +E K + R K S EDSEDS+ ++V +D+ S +
Sbjct: 1351 ESGEEKKTKPKEHKEVKGRNRR-KVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKK 1409
Query: 83 KEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDD 142
E +N R +Q + K +E + S E+EEE++ +E++ +E+ E+DD
Sbjct: 1410 AELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDD 1469
Query: 143 DSDYGSSKKKNKKMVKKSK 161
G +KK +K++K K
Sbjct: 1470 SKSPGKGRKKIRKILKDDK 1488
Score = 51.6 bits (122), Expect = 6e-07
Identities = 45/217 (20%), Positives = 89/217 (41%), Gaps = 27/217 (12%)
Query: 22 ADEDYGRDSGPPTKKIRSSPREAKN----KRRSGKNSQEDSEDSEDKDVKTKK------- 70
+DED D P K R+ + +N + ++ NS+ DS+ E K + +
Sbjct: 1286 SDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKL 1345
Query: 71 --DDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDE------ 122
D S E+ + + ++HK V+ + + + + E SEE E EDE
Sbjct: 1346 TVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTR 1405
Query: 123 ----APFQEKDSGSDEDF----LMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRL 174
A +E + + +D S S + ++ K+ + E +E++ +
Sbjct: 1406 SAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEED 1465
Query: 175 KATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEE 211
+ + SP KG+ K+ + + +T + +E+EE
Sbjct: 1466 ENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEE 1502
Score = 42.7 bits (99), Expect = 3e-04
Identities = 62/248 (25%), Positives = 99/248 (39%), Gaps = 44/248 (17%)
Query: 32 PPTKKIRSSPREAKNKR-------RSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSED--- 81
P TK SS E +K+ ++ K SQE S D D + K +++ SAE + D
Sbjct: 842 PNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSD--DAERKQERETFSSAEGTVDKDT 899
Query: 82 ---EKEDHKNVRQQRQAAS----KAASKQREMLMEDVGSEEEQEEEDE-------APFQE 127
E D +QQ A++ K + K++ +V E +E+ + Q+
Sbjct: 900 TIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQD 959
Query: 128 KDSGSDEDFLMEDDDDSDYGSSKKKNKK-MVKKSKPERKEKKMPK--------------- 171
S E FL +D D KK++KK +K KP +KK+ K
Sbjct: 960 GLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKL 1019
Query: 172 -PRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSG 230
R + P +K + K G K SK+ ++ +E EK T + S
Sbjct: 1020 PEREEICHFPKGIK-QIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSE 1078
Query: 231 DEGSEDEA 238
D+ S++ A
Sbjct: 1079 DKKSKNGA 1086
Score = 42.7 bits (99), Expect = 3e-04
Identities = 42/179 (23%), Positives = 80/179 (44%), Gaps = 18/179 (10%)
Query: 6 RNRKVV-----DYSQFQESDDADE--DYGRDSGPPTKKIRSSPREA-------KNKRRSG 51
RNR+ V + S FQES ++E + + P T+ + + E K KRR
Sbjct: 1369 RNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRI 1428
Query: 52 KNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDV 111
K ++ S +++ + +++ E+ E+E+E+ ++ ++ K K R++L +D
Sbjct: 1429 KVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDK 1488
Query: 112 GSEEEQ---EEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSK-KKNKKMVKKSKPERKE 166
E Q +EE+E + + + + L E + D +K K+V E KE
Sbjct: 1489 LRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKE 1547
Score = 37.7 bits (86), Expect = 0.009
Identities = 56/249 (22%), Positives = 98/249 (39%), Gaps = 51/249 (20%)
Query: 18 ESDDADED-------YGRDS------GPPTKKIR---SSPREAKNKRRSGKNSQEDS--- 58
+S D+ ED YGR+ G ++K + SS E + + G NS +
Sbjct: 1072 DSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKR 1131
Query: 59 -EDSEDKDVKTKKDDSH-----SAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVG 112
E E +++ +K++ S+ D+E+ ED+K ++QR ++ K A +E +
Sbjct: 1132 IELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKK-KKQRTSSKKKAVIVKEKKRNSLR 1190
Query: 113 SEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKP 172
+ ++++ D D +EDDD + G +K+ KP
Sbjct: 1191 TSTKRKQADITSSSSSD--------IEDDDQNSIGEGSSDEQKI--------------KP 1228
Query: 173 RLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPE--KSG 230
+ V S G SK S T ++D +PE+ KK S
Sbjct: 1229 VTENLVLSSHTGFCQSSGDEALSK-SVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD 1287
Query: 231 DEGSEDEAP 239
++GS D+ P
Sbjct: 1288 EDGSSDDEP 1296
Score = 37.0 bits (84), Expect = 0.016
Identities = 54/253 (21%), Positives = 98/253 (38%), Gaps = 52/253 (20%)
Query: 1 MSRPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAK------NKRRSGKNS 54
+ RP V S +E ++ ++ + S P KK + + ++ NK K S
Sbjct: 664 LRRPTETNPVTSNSD-EECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQS 722
Query: 55 Q--EDSEDSED-----KDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREML 107
+ + + DS++ K+V S S D + +HK + + A K
Sbjct: 723 ETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGK--------- 773
Query: 108 MEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEK 167
+D+ + K S S DF D+ G S K+ + KK + + E
Sbjct: 774 ------------DDKGKRKRKSSTSGSDF------DTKKGKS-AKSSIISKKKRQTQSES 814
Query: 168 KMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPE 227
L+ +K K+G A++ +K++ P+ K+ D + KK + +
Sbjct: 815 SNYDSELE-----KEIKSMSKIG---AARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHK 866
Query: 228 --KSGDEGSEDEA 238
K+ EGS D+A
Sbjct: 867 NLKTSQEGSSDDA 879
Score = 35.8 bits (81), Expect = 0.035
Identities = 51/266 (19%), Positives = 100/266 (37%), Gaps = 59/266 (22%)
Query: 14 SQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDS 73
S +ES + ++ + + K + ++ + R S K Q D S D++ DD
Sbjct: 1156 SDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIED--DDQ 1213
Query: 74 HSAEDSEDEKEDHKNVRQQ----------RQAASKAASKQ-------------------R 104
+S + +++ K V + + + +A SK +
Sbjct: 1214 NSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAK 1273
Query: 105 EMLMEDV----GSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKS 160
+ML+E++ S+E+ +DE +K +G ++ + G + KN ++ +S
Sbjct: 1274 KMLLEEIKANLSSDEDGSSDDEPEEGKKRTGK--------QNEENPGDEEAKN-QVNSES 1324
Query: 161 KPERKEKKMPKPR---LKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPE 217
+ +E K P+ R L+ +T S ++ +EK PKE E
Sbjct: 1325 DSDSEESKKPRYRHRLLRHKLTVSD------------GESGEEKKTKPKEHKEVKGRNRR 1372
Query: 218 KKTSTSPPPEKSGDEGSEDEAPSGED 243
K +S + G +E ED
Sbjct: 1373 KVSSEDSEDSDFQESGVSEEVSESED 1398
Score = 32.3 bits (72), Expect = 0.38
Identities = 39/218 (17%), Positives = 81/218 (37%), Gaps = 20/218 (9%)
Query: 36 KIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKT----KKDDSHSAEDSEDEKEDHKNVRQ 91
K ++ + ++R S D + + K K+ KK +E S + E K ++
Sbjct: 768 KTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKS 827
Query: 92 QRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKK 151
+ + +K+R +D S E+++ + D+ ++ + SD K+
Sbjct: 828 MSKIGAARTTKKRIPNTKDFDSSEDEKHSKKG----MDNQGHKNLKTSQEGSSDDAERKQ 883
Query: 152 KNKKMVKKSKPERKE-------KKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPS 204
+ + K+ ++PK + + T K GK T+ + K
Sbjct: 884 ERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETK 943
Query: 205 PKEEDEEPESPPEKKTSTSPPPEK-----SGDEGSEDE 237
K + + ++ + + S EK DE SED+
Sbjct: 944 EKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDD 981
Score = 30.0 bits (66), Expect = 1.9
Identities = 28/143 (19%), Positives = 55/143 (38%), Gaps = 6/143 (4%)
Query: 73 SHSAEDSEDEKEDHKNVRQQRQAASKAASKQREML--MEDVGSEEEQEEEDEAPFQEKDS 130
+HS+E+SE+ + Q + +M+ ++ G+ ++ + + K
Sbjct: 23 AHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRK 82
Query: 131 GSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGK-- 188
S +E DD+ + S+ + + +PK + V P PV + K
Sbjct: 83 PSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKGTV--IVQPEPVLNEDKDD 140
Query: 189 VGRPTASKASKEKTPSPKEEDEE 211
P SK KT + K+ E+
Sbjct: 141 FKGPEFRSRSKMKTENLKKRGED 163
Score = 29.3 bits (64), Expect = 3.2
Identities = 39/177 (22%), Positives = 67/177 (37%), Gaps = 17/177 (9%)
Query: 40 SPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKA 99
S EAK R+ Q DSE ++V T++ ++ + E +K D K Q A +
Sbjct: 458 SKSEAKLSRK-----QVDSEHMH-QNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANT-- 509
Query: 100 ASKQREM--------LMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKK 151
S+ +M + ED+ E E ++ + GS + S K
Sbjct: 510 -SEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSK 568
Query: 152 KNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEE 208
N+ +K + K++ +++ SP+KG P K +PK E
Sbjct: 569 DNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLE 625
>gi|4557509 cylicin 2 [Homo sapiens]
Length = 348
Score = 57.4 bits (137), Expect = 1e-08
Identities = 55/217 (25%), Positives = 93/217 (42%), Gaps = 16/217 (7%)
Query: 33 PTKKIRSSPREAK-NKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQ 91
PT+ + + A+ K+ K +Q+D+ DSE ++K K DS +D E KE+ + ++
Sbjct: 101 PTRTVEVDSKAAEIGKKGEDKTTQKDTTDSES-ELKQGKKDSKKGKDIEKGKEEKLDAKK 159
Query: 92 QRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSK- 150
+ K A K ++ E +E+ + + +KDS +D E + + G+ K
Sbjct: 160 DSKKGKKDAEKGKDSATE--SEDEKGGAKKDNKKDKKDSNKGKDSATESEGEKG-GTEKD 216
Query: 151 -KKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKE--------K 201
KK KK KK K E + K K KG + A K +KE K
Sbjct: 217 SKKGKKDSKKGKDSAIELQAVKADEKKDEDGKKDANKGDESK-DAKKDAKEIKKGKKDKK 275
Query: 202 TPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGSEDEA 238
PS + D + + E K + +K + +E E+
Sbjct: 276 KPSSTDSDSKDDVKKESKKDATKDAKKVAKKDTEKES 312
Score = 54.7 bits (130), Expect = 7e-08
Identities = 50/213 (23%), Positives = 89/213 (41%), Gaps = 9/213 (4%)
Query: 34 TKKIRSSPREAKNKRRSGKNSQEDSEDSED--KDVKTKKDDSHSAEDSEDEKEDHKN-VR 90
T S ++ K + GK+ ++ E+ D KD K K D+ +DS E ED K +
Sbjct: 127 TTDSESELKQGKKDSKKGKDIEKGKEEKLDAKKDSKKGKKDAEKGKDSATESEDEKGGAK 186
Query: 91 QQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMED---DDDSDYG 147
+ + K ++K ++ E G + E++ + ++ G D ++ D+ D
Sbjct: 187 KDNKKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIELQAVKADEKKDED 246
Query: 148 SSKKKNK-KMVKKSKPERKE-KKMPKPRLKATVTPSPVKGK-GKVGRPTASKASKEKTPS 204
K NK K +K + KE KK K + K + T S K K + A+K +K+
Sbjct: 247 GKKDANKGDESKDAKKDAKEIKKGKKDKKKPSSTDSDSKDDVKKESKKDATKDAKKVAKK 306
Query: 205 PKEEDEEPESPPEKKTSTSPPPEKSGDEGSEDE 237
E++ KK + + + +DE
Sbjct: 307 DTEKESADSKKDAKKNAKKDAKKDAKKNAKKDE 339
Score = 53.9 bits (128), Expect = 1e-07
Identities = 46/200 (23%), Positives = 84/200 (42%), Gaps = 19/200 (9%)
Query: 23 DEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSED---KDVKTKKDDSHSAEDS 79
D + G++ KK ++ K GK+S +SED + KD K K DS+ +DS
Sbjct: 146 DIEKGKEEKLDAKK---DSKKGKKDAEKGKDSATESEDEKGGAKKDNKKDKKDSNKGKDS 202
Query: 80 EDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLME 139
E E K ++ K SK+ + ++ + + E++DE ++ + G
Sbjct: 203 ATESEGEKGGTEKDSKKGKKDSKKGKDSAIELQAVKADEKKDEDGKKDANKG-------- 254
Query: 140 DDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASK 199
D KK+ K +KK K ++K+ K V K K + A K ++
Sbjct: 255 -----DESKDAKKDAKEIKKGKKDKKKPSSTDSDSKDDVKKESKKDATKDAKKVAKKDTE 309
Query: 200 EKTPSPKEEDEEPESPPEKK 219
+++ K++ ++ KK
Sbjct: 310 KESADSKKDAKKNAKKDAKK 329
Score = 48.5 bits (114), Expect = 5e-06
Identities = 39/177 (22%), Positives = 81/177 (45%), Gaps = 24/177 (13%)
Query: 18 ESDDADEDYGRDSGPPTKKIRS-SPREAKNKRRSGKNSQEDSEDSEDKDVKTKKD----- 71
+ D D + G+DS ++ + + +++K ++ K ++ + + + KKD
Sbjct: 190 KKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIELQAVKADEKKDEDGKK 249
Query: 72 DSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSG 131
D++ ++S+D K+D K +++ ++ K +S D S+++ ++E + KD+
Sbjct: 250 DANKGDESKDAKKDAKEIKKGKKDKKKPSST-------DSDSKDDVKKESK-----KDAT 297
Query: 132 SDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGK 188
D + + D + + SKK KK KK + +K K K K KGK
Sbjct: 298 KDAKKVAKKDTEKESADSKKDAKKNAKKDAKKDAKKNAKKDEKK------DAKKKGK 348
Score = 44.3 bits (103), Expect = 1e-04
Identities = 49/219 (22%), Positives = 92/219 (42%), Gaps = 23/219 (10%)
Query: 28 RDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHK 87
R S P+ + + + K R +S+ + +D T+KD + S + + K+D K
Sbjct: 83 RISERPSVYLAARRQPLKPTRTVEVDSKAAEIGKKGEDKTTQKDTTDSESELKQGKKDSK 142
Query: 88 NVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYG 147
K +++ + G EE+ + + ++ +KD+ +D E +D+ G
Sbjct: 143 --------------KGKDI---EKGKEEKLDAKKDSKKGKKDAEKGKDSATESEDEK--G 183
Query: 148 SSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGK--GKVGRPTASKASKEKTPSP 205
+KK NKK KK + K+ K KGK K G+ +A + K
Sbjct: 184 GAKKDNKK-DKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIELQAVKADEK 242
Query: 206 KEEDEEPESPPEKKTSTSPPPEKSGDEGSED-EAPSGED 243
K+ED + ++ ++ + K +G +D + PS D
Sbjct: 243 KDEDGKKDANKGDESKDAKKDAKEIKKGKKDKKKPSSTD 281
>gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo
sapiens]
Length = 1188
Score = 57.4 bits (137), Expect = 1e-08
Identities = 45/188 (23%), Positives = 86/188 (45%), Gaps = 40/188 (21%)
Query: 52 KNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDV 111
K ++D E+S ++ +K ++ + SE E+ N +R+ + + R + DV
Sbjct: 418 KEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDV 477
Query: 112 GSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMV--KKSKPERKEKKM 169
S +++ EE++ + KD+ ++ D D DY +++KK +++ +K+ P++KEKK+
Sbjct: 478 NSIKKEIEEEKTEDKLKDNDTE-----NKDVDDDYETAEKKENELLLGRKNTPKQKEKKI 532
Query: 170 PKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKS 229
K++ S K+ DEE E E++ + S K
Sbjct: 533 -----------------------------KKQEDSDKDSDEEEEKSQEREETES----KC 559
Query: 230 GDEGSEDE 237
EG EDE
Sbjct: 560 DSEGEEDE 567
Score = 47.4 bits (111), Expect = 1e-05
Identities = 45/211 (21%), Positives = 95/211 (45%), Gaps = 22/211 (10%)
Query: 18 ESDDADEDYGRDSGPPTKKI---RSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSH 74
E+ D D+DY + + +++P++ + K + ++S +DS++ E+K + ++ +S
Sbjct: 499 ENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQEREETESK 558
Query: 75 SAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSD- 133
+ E+++ED + + K + + + E + + ++ E + G +
Sbjct: 559 CDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYE-ASIKSTEIDDGEVLYLVHYYGWNV 617
Query: 134 --EDFLMEDDD--DSDYGSSKKKNKKMVK---------KSKPERKEKKMPKPRLKATVTP 180
++++ D D G KKK KK K K ER++ K +P LK+T++
Sbjct: 618 RYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSS 677
Query: 181 SPVKGKGKVGRPTASKASKEKTPSPKEEDEE 211
+ G K TA+ K + S E E+
Sbjct: 678 NMPYGLSK----TANSEGKSDSCSSDSETED 704
Score = 38.9 bits (89), Expect = 0.004
Identities = 46/252 (18%), Positives = 93/252 (36%), Gaps = 39/252 (15%)
Query: 29 DSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTK-KDDSHSAEDSEDEKEDHK 87
DS +++ + + +RR ++ ++ E++ + K KD+ +D +D+ E +
Sbjct: 452 DSNSESEREEIELKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAE 511
Query: 88 NVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYG 147
+ K KQ+E ++ ++ +E+E QE++ + ++D+ D
Sbjct: 512 KKENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDME 571
Query: 148 SSKKKNKKMVKKSKPERKEKKMPKPRLKAT-----------------------VTPSPVK 184
K VK + K +K+ + +K+T V +
Sbjct: 572 PCLTGTKVKVKYGRG--KTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRII 629
Query: 185 GKGKVGRPTASKASKEKTPSPKEEDEEPES---------PPEKKTSTSPPP----EKSGD 231
G P + K K E+DE+ + PP K T +S P + +
Sbjct: 630 WPLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANS 689
Query: 232 EGSEDEAPSGED 243
EG D S +
Sbjct: 690 EGKSDSCSSDSE 701
Score = 29.3 bits (64), Expect = 3.2
Identities = 44/206 (21%), Positives = 76/206 (36%), Gaps = 41/206 (19%)
Query: 40 SPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKA 99
+P AK R ++S +ED +++ E SE+E ED + +
Sbjct: 133 TPVIAKKTNRGRRSSLPVTEDEKEE------------ESSEEEDEDKRRLND-------- 172
Query: 100 ASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDD--------DDSDYGSSKK 151
E+L + V E + P ++D ++ D D Y ++K
Sbjct: 173 -----ELLGKVVSVVSATERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARK 227
Query: 152 KNKKMVKKSKPERKEKKMPKPR-----LKATVTPSPVKGKGKVGRPTASKASKEKTPSPK 206
K++ + PE + P + LK V P K + S +S ++ P
Sbjct: 228 DIKEVDILNLPESELSTKPGLQKASIFLKTRVVPD--NWKMDISEILESSSSDDED-GPA 284
Query: 207 EEDEEPESPPEKKTSTSPPPEKSGDE 232
EE++E + KKT P E+ E
Sbjct: 285 EENDEEKEKEAKKTEEEVPEEELDPE 310
>gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo
sapiens]
Length = 1203
Score = 57.4 bits (137), Expect = 1e-08
Identities = 45/188 (23%), Positives = 86/188 (45%), Gaps = 40/188 (21%)
Query: 52 KNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDV 111
K ++D E+S ++ +K ++ + SE E+ N +R+ + + R + DV
Sbjct: 418 KEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDV 477
Query: 112 GSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMV--KKSKPERKEKKM 169
S +++ EE++ + KD+ ++ D D DY +++KK +++ +K+ P++KEKK+
Sbjct: 478 NSIKKEIEEEKTEDKLKDNDTE-----NKDVDDDYETAEKKENELLLGRKNTPKQKEKKI 532
Query: 170 PKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKS 229
K++ S K+ DEE E E++ + S K
Sbjct: 533 -----------------------------KKQEDSDKDSDEEEEKSQEREETES----KC 559
Query: 230 GDEGSEDE 237
EG EDE
Sbjct: 560 DSEGEEDE 567
Score = 47.4 bits (111), Expect = 1e-05
Identities = 45/211 (21%), Positives = 95/211 (45%), Gaps = 22/211 (10%)
Query: 18 ESDDADEDYGRDSGPPTKKI---RSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSH 74
E+ D D+DY + + +++P++ + K + ++S +DS++ E+K + ++ +S
Sbjct: 499 ENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQEREETESK 558
Query: 75 SAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSD- 133
+ E+++ED + + K + + + E + + ++ E + G +
Sbjct: 559 CDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYE-ASIKSTEIDDGEVLYLVHYYGWNV 617
Query: 134 --EDFLMEDDD--DSDYGSSKKKNKKMVK---------KSKPERKEKKMPKPRLKATVTP 180
++++ D D G KKK KK K K ER++ K +P LK+T++
Sbjct: 618 RYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSS 677
Query: 181 SPVKGKGKVGRPTASKASKEKTPSPKEEDEE 211
+ G K TA+ K + S E E+
Sbjct: 678 NMPYGLSK----TANSEGKSDSCSSDSETED 704
Score = 38.9 bits (89), Expect = 0.004
Identities = 46/252 (18%), Positives = 93/252 (36%), Gaps = 39/252 (15%)
Query: 29 DSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTK-KDDSHSAEDSEDEKEDHK 87
DS +++ + + +RR ++ ++ E++ + K KD+ +D +D+ E +
Sbjct: 452 DSNSESEREEIELKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAE 511
Query: 88 NVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYG 147
+ K KQ+E ++ ++ +E+E QE++ + ++D+ D
Sbjct: 512 KKENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDME 571
Query: 148 SSKKKNKKMVKKSKPERKEKKMPKPRLKAT-----------------------VTPSPVK 184
K VK + K +K+ + +K+T V +
Sbjct: 572 PCLTGTKVKVKYGRG--KTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRII 629
Query: 185 GKGKVGRPTASKASKEKTPSPKEEDEEPES---------PPEKKTSTSPPP----EKSGD 231
G P + K K E+DE+ + PP K T +S P + +
Sbjct: 630 WPLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANS 689
Query: 232 EGSEDEAPSGED 243
EG D S +
Sbjct: 690 EGKSDSCSSDSE 701
Score = 29.3 bits (64), Expect = 3.2
Identities = 44/206 (21%), Positives = 76/206 (36%), Gaps = 41/206 (19%)
Query: 40 SPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKA 99
+P AK R ++S +ED +++ E SE+E ED + +
Sbjct: 133 TPVIAKKTNRGRRSSLPVTEDEKEE------------ESSEEEDEDKRRLND-------- 172
Query: 100 ASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDD--------DDSDYGSSKK 151
E+L + V E + P ++D ++ D D Y ++K
Sbjct: 173 -----ELLGKVVSVVSATERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARK 227
Query: 152 KNKKMVKKSKPERKEKKMPKPR-----LKATVTPSPVKGKGKVGRPTASKASKEKTPSPK 206
K++ + PE + P + LK V P K + S +S ++ P
Sbjct: 228 DIKEVDILNLPESELSTKPGLQKASIFLKTRVVPD--NWKMDISEILESSSSDDED-GPA 284
Query: 207 EEDEEPESPPEKKTSTSPPPEKSGDE 232
EE++E + KKT P E+ E
Sbjct: 285 EENDEEKEKEAKKTEEEVPEEELDPE 310
>gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo
sapiens]
Length = 1257
Score = 57.4 bits (137), Expect = 1e-08
Identities = 45/188 (23%), Positives = 86/188 (45%), Gaps = 40/188 (21%)
Query: 52 KNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDV 111
K ++D E+S ++ +K ++ + SE E+ N +R+ + + R + DV
Sbjct: 418 KEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDV 477
Query: 112 GSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMV--KKSKPERKEKKM 169
S +++ EE++ + KD+ ++ D D DY +++KK +++ +K+ P++KEKK+
Sbjct: 478 NSIKKEIEEEKTEDKLKDNDTE-----NKDVDDDYETAEKKENELLLGRKNTPKQKEKKI 532
Query: 170 PKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKS 229
K++ S K+ DEE E E++ + S K
Sbjct: 533 -----------------------------KKQEDSDKDSDEEEEKSQEREETES----KC 559
Query: 230 GDEGSEDE 237
EG EDE
Sbjct: 560 DSEGEEDE 567
Score = 47.4 bits (111), Expect = 1e-05
Identities = 45/211 (21%), Positives = 95/211 (45%), Gaps = 22/211 (10%)
Query: 18 ESDDADEDYGRDSGPPTKKI---RSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSH 74
E+ D D+DY + + +++P++ + K + ++S +DS++ E+K + ++ +S
Sbjct: 499 ENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQEREETESK 558
Query: 75 SAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSD- 133
+ E+++ED + + K + + + E + + ++ E + G +
Sbjct: 559 CDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYE-ASIKSTEIDDGEVLYLVHYYGWNV 617
Query: 134 --EDFLMEDDD--DSDYGSSKKKNKKMVK---------KSKPERKEKKMPKPRLKATVTP 180
++++ D D G KKK KK K K ER++ K +P LK+T++
Sbjct: 618 RYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSS 677
Query: 181 SPVKGKGKVGRPTASKASKEKTPSPKEEDEE 211
+ G K TA+ K + S E E+
Sbjct: 678 NMPYGLSK----TANSEGKSDSCSSDSETED 704
Score = 38.9 bits (89), Expect = 0.004
Identities = 46/252 (18%), Positives = 93/252 (36%), Gaps = 39/252 (15%)
Query: 29 DSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTK-KDDSHSAEDSEDEKEDHK 87
DS +++ + + +RR ++ ++ E++ + K KD+ +D +D+ E +
Sbjct: 452 DSNSESEREEIELKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAE 511
Query: 88 NVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYG 147
+ K KQ+E ++ ++ +E+E QE++ + ++D+ D
Sbjct: 512 KKENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDME 571
Query: 148 SSKKKNKKMVKKSKPERKEKKMPKPRLKAT-----------------------VTPSPVK 184
K VK + K +K+ + +K+T V +
Sbjct: 572 PCLTGTKVKVKYGRG--KTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRII 629
Query: 185 GKGKVGRPTASKASKEKTPSPKEEDEEPES---------PPEKKTSTSPPP----EKSGD 231
G P + K K E+DE+ + PP K T +S P + +
Sbjct: 630 WPLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANS 689
Query: 232 EGSEDEAPSGED 243
EG D S +
Sbjct: 690 EGKSDSCSSDSE 701
Score = 29.3 bits (64), Expect = 3.2
Identities = 44/206 (21%), Positives = 76/206 (36%), Gaps = 41/206 (19%)
Query: 40 SPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKA 99
+P AK R ++S +ED +++ E SE+E ED + +
Sbjct: 133 TPVIAKKTNRGRRSSLPVTEDEKEE------------ESSEEEDEDKRRLND-------- 172
Query: 100 ASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDD--------DDSDYGSSKK 151
E+L + V E + P ++D ++ D D Y ++K
Sbjct: 173 -----ELLGKVVSVVSATERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARK 227
Query: 152 KNKKMVKKSKPERKEKKMPKPR-----LKATVTPSPVKGKGKVGRPTASKASKEKTPSPK 206
K++ + PE + P + LK V P K + S +S ++ P
Sbjct: 228 DIKEVDILNLPESELSTKPGLQKASIFLKTRVVPD--NWKMDISEILESSSSDDED-GPA 284
Query: 207 EEDEEPESPPEKKTSTSPPPEKSGDE 232
EE++E + KKT P E+ E
Sbjct: 285 EENDEEKEKEAKKTEEEVPEEELDPE 310
>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
Length = 282
Score = 56.2 bits (134), Expect = 2e-08
Identities = 33/130 (25%), Positives = 67/130 (51%), Gaps = 5/130 (3%)
Query: 12 DYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKD 71
D + E D ++ G + G K+ + ++ ++ + +G++ +E ED ++++ + +
Sbjct: 148 DKDEKGEEDGKEDKNGNEKGEDAKE-KEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETG 206
Query: 72 DSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSG 131
D ED + EK D K + + K K+RE ED G EE+ +++ +E++ G
Sbjct: 207 DGKENEDGK-EKGDKK---EGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEG 262
Query: 132 SDEDFLMEDD 141
+ED + EDD
Sbjct: 263 KEEDEIKEDD 272
Score = 50.1 bits (118), Expect = 2e-06
Identities = 47/222 (21%), Positives = 96/222 (43%), Gaps = 23/222 (10%)
Query: 23 DEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDE 82
+EDY ++ KI +P K + +E+ ED+ +K +K ++ +AE +E
Sbjct: 73 EEDYNENAKNGEAKITEAPASEKE---IVEVKEENIEDATEKG--GEKKEAVAAEVKNEE 127
Query: 83 KEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSD-EDFLMEDD 141
++ ++ Q + +A + ++ E+ G E++ E +EK+ G ED +
Sbjct: 128 EDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGE 187
Query: 142 DDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEK 201
D + G +K+ + +K + KE + K KG K G+ K +++
Sbjct: 188 DGKEKGEDEKEEED--RKETGDGKENEDGKE-----------KGDKKEGKDVKVKEDEKE 234
Query: 202 TPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGSEDEAPSGED 243
+E+ +E E E++ K +EG E++ +D
Sbjct: 235 ----REDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDEIKEDD 272
Score = 48.1 bits (113), Expect = 7e-06
Identities = 35/155 (22%), Positives = 77/155 (49%), Gaps = 11/155 (7%)
Query: 15 QFQESDDADEDYGRDSGPPTK--KIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDD 72
Q ++ +D +E+ G ++G K K +E KN G++++E + + +D K +D
Sbjct: 130 QKEDEEDQNEEKG-EAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGED 188
Query: 73 SHSAEDSEDEKEDHKNV---RQQRQAASKAASKQ-REMLMEDVGSEEEQEEEDEAPFQEK 128
+ E E+ED K ++ K K+ +++ +++ E E +EDE E+
Sbjct: 189 GKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGG-NEE 247
Query: 129 DSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPE 163
++G +++ L E+++ + K+ + KK +P+
Sbjct: 248 EAGKEKEDLKEEEEGKEEDEIKEDDG---KKEEPQ 279
Score = 47.8 bits (112), Expect = 9e-06
Identities = 48/234 (20%), Positives = 92/234 (39%), Gaps = 36/234 (15%)
Query: 32 PPTKKIRSSPREAKNKRRSGKNSQEDSEDS---------------EDKDVKTKKDDSHSA 76
P T +++ + K ++ + E++ D+ ED + K ++
Sbjct: 29 PVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKIT 88
Query: 77 EDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEA-PFQEKDSGSDED 135
E EKE + + + A++ +++E + +V +EEE ++EDE +EK ED
Sbjct: 89 EAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKED 148
Query: 136 FLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTAS 195
+D+ + G K + + +K + KK KG G+ G+
Sbjct: 149 ---KDEKGEEDGKEDKNGNEKGEDAKEKEDGKK-----------GEDGKGNGEDGKEKGE 194
Query: 196 KASKEKTPSPKEEDEEPESPPEK------KTSTSPPPEKSGDEGSEDEAPSGED 243
+E+ + +E E EK K EK ++G EDE + E+
Sbjct: 195 DEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEE 248
Score = 44.7 bits (104), Expect = 7e-05
Identities = 28/119 (23%), Positives = 60/119 (50%), Gaps = 15/119 (12%)
Query: 17 QESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSG-----KNSQEDSEDSEDKDVKTKKD 71
++ D + G+ +G K+ +E ++++ +G ++ +E + E KDVK K+D
Sbjct: 172 EKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKED 231
Query: 72 DSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDS 130
+ ++ ED KED ++ A ++ ++ E+ G EE++ +ED+ +E S
Sbjct: 232 E----KEREDGKEDEGGNEEE------AGKEKEDLKEEEEGKEEDEIKEDDGKKEEPQS 280
>gi|117553584 adaptor-related protein complex 3, delta 1 subunit
isoform 1 [Homo sapiens]
Length = 1112
Score = 56.2 bits (134), Expect = 2e-08
Identities = 48/212 (22%), Positives = 82/212 (38%), Gaps = 19/212 (8%)
Query: 35 KKIRSSPREAKNKRRSGKNSQEDSED---SEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQ 91
++ + +E K KRR E ED ++ D+ T++ ++ ED+K+ + R
Sbjct: 651 RRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRA 710
Query: 92 QRQAASKA-ASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSK 150
K A ++ + + +E + E + P EK S + K
Sbjct: 711 LDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKK------------KEK 758
Query: 151 KKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDE 210
K +K K K + KEKK + TP P P+ + KT + EED+
Sbjct: 759 KHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDD 818
Query: 211 EPESPPEKKTSTSPPPEKSGDEGSEDEAPSGE 242
+KK SP P+K ++E G+
Sbjct: 819 AEGQDQDKK---SPKPKKKKHRKEKEERTKGK 847
Score = 38.5 bits (88), Expect = 0.005
Identities = 41/201 (20%), Positives = 73/201 (36%), Gaps = 23/201 (11%)
Query: 17 QESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSA 76
++ D ++ Y K + S + K R+ + S+ +D + K+KK
Sbjct: 699 EDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEK 758
Query: 77 EDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVG---SEEEQEEEDEAPFQEKDSGSD 133
+ E E++ K K++E ED+ S AP +
Sbjct: 759 KHKEKERDKEKK-------------KEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDEC 805
Query: 134 EDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPT 193
ED E + D + ++KK K K + +++K + + K P + G P
Sbjct: 806 EDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPV 865
Query: 194 ASKASKEKTPSPKEEDEEPES 214
+ A P+EE PES
Sbjct: 866 QNGA-------PEEEQLPPES 879
Score = 37.4 bits (85), Expect = 0.012
Identities = 44/194 (22%), Positives = 73/194 (37%), Gaps = 20/194 (10%)
Query: 63 DKDVKTKKDDSHSAE---DSEDEKEDHKNVRQQRQAASKAASKQREML-MEDVGSEEEQE 118
D+ VK +++ H + D +K K + +R+ +S ++ + V E+
Sbjct: 631 DQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEM 690
Query: 119 EEDEAPFQEKDSGSDEDFLMEDDD-DSDYGSSKK----KNKKMVKKSKPERK----EKKM 169
E+ P E D ++ + D D D S+K K++ PE+ EKK
Sbjct: 691 PENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKS 750
Query: 170 PKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKS 229
KP+ K + K K K KEK + PP + +P P
Sbjct: 751 KKPKKKEKKHKEKERDKEK-------KKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTD 803
Query: 230 GDEGSEDEAPSGED 243
E ++ EA ED
Sbjct: 804 ECEDAKTEAQGEED 817
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 56.2 bits (134), Expect = 2e-08
Identities = 39/177 (22%), Positives = 78/177 (44%), Gaps = 17/177 (9%)
Query: 38 RSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAAS 97
R RE + KR GK ++ E+++ K ++ + + E E EK K +++ + +
Sbjct: 69 RKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSK 128
Query: 98 KAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMV 157
+ ++R+ E+ EE +E E + +EK+ E KK+ +K V
Sbjct: 129 EGKERERK---EERKREERKERERKKEEREKERERKE--------------RKKRERKQV 171
Query: 158 KKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPES 214
+ + ERKEK+ + + + K + + R K K+K KE ++ ++
Sbjct: 172 GEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQT 228
Score = 50.1 bits (118), Expect = 2e-06
Identities = 42/185 (22%), Positives = 84/185 (45%), Gaps = 20/185 (10%)
Query: 21 DADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKD---DSHSAE 77
+ +++ R+ G KK E + K+R + ++ E+ E + K KK+ S +
Sbjct: 72 EREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGK 131
Query: 78 DSEDEKEDHKNVRQQRQAASKAASKQREML------MEDVGSEEEQEEEDEAPFQEKDSG 131
+ E ++E + R++R+ + K+RE + VG +EE+ +E E ++K
Sbjct: 132 ERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRER 191
Query: 132 SDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGR 191
+ ++ E + +K ++ KK + +++E+K K R K T K +GK R
Sbjct: 192 NRKERKKERE---------RKERRERKKERKKKEERK--KERQKDRQTNWREKERGKRER 240
Query: 192 PTASK 196
K
Sbjct: 241 KERKK 245
Score = 47.4 bits (111), Expect = 1e-05
Identities = 40/196 (20%), Positives = 82/196 (41%), Gaps = 7/196 (3%)
Query: 36 KIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQA 95
+IR RE + R+ GK +E E ++ + +K + E K++ K R++ +
Sbjct: 37 EIREREREIET-RKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEER 95
Query: 96 ASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKK 155
K +++E G E+E+ ++ E +E+ S E E ++ K++ +K
Sbjct: 96 ERKKRRREKE---NKEGEEKEKRKKKEK--KERGRTSKEGKERERKEERKREERKERERK 150
Query: 156 MVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESP 215
++ K ++++ + R + K K + R + KE+ +E E E
Sbjct: 151 KEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKER-KKERERKERRERK 209
Query: 216 PEKKTSTSPPPEKSGD 231
E+K E+ D
Sbjct: 210 KERKKKEERKKERQKD 225
Score = 35.0 bits (79), Expect = 0.059
Identities = 32/160 (20%), Positives = 65/160 (40%), Gaps = 17/160 (10%)
Query: 78 DSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFL 137
+ E E E K +++R++ K ++RE E E+E + E +EK ++
Sbjct: 40 EREREIETRKEGKKERESERKKERREREKRKR----EREKERKRERGKKEKKGERKKE-- 93
Query: 138 MEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKA 197
+++ K+ +K E +EK+ K + K + +GK + + +
Sbjct: 94 -----------ERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKRE 142
Query: 198 SKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGSEDE 237
+++ KEE E+ E+K + +E E E
Sbjct: 143 ERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKE 182
Score = 33.1 bits (74), Expect = 0.22
Identities = 31/173 (17%), Positives = 68/173 (39%), Gaps = 29/173 (16%)
Query: 63 DKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDE 122
+++++T+K+ ++ E E++ + R++R+ + K+ E G +++E E +
Sbjct: 42 EREIETRKEGK---KERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERK 98
Query: 123 APFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSP 182
+EK++ E+ K K+ K+ K + K K R
Sbjct: 99 KRRREKENKEGEE----------------KEKRKKKEKKERGRTSKEGKER--------- 133
Query: 183 VKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGSE 235
+ K + R + ++K KE + + E+K E+ E E
Sbjct: 134 -ERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKE 185
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.294 0.118 0.309
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,541,881
Number of Sequences: 37866
Number of extensions: 793901
Number of successful extensions: 22544
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 848
Number of HSP's successfully gapped in prelim test: 1295
Number of HSP's that attempted gapping in prelim test: 6473
Number of HSP's gapped (non-prelim): 9083
length of query: 243
length of database: 18,247,518
effective HSP length: 99
effective length of query: 144
effective length of database: 14,498,784
effective search space: 2087824896
effective search space used: 2087824896
T: 11
A: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 44 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.