Search of human proteins with 134304846

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2
[Homo sapiens]
         (1591 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo...  3112   0.0  
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo...  3106   0.0  
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   122   2e-27
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]        119   2e-26
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]        119   2e-26
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   117   9e-26
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                 117   9e-26
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]   116   2e-25
gi|4506751 restin isoform a [Homo sapiens]                            115   3e-25
gi|38044112 restin isoform b [Homo sapiens]                           115   4e-25
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    113   1e-24
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   113   2e-24
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    112   4e-24
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   111   5e-24
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   111   5e-24
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   111   5e-24
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   111   5e-24
gi|19924131 RAD50 homolog isoform 2 [Homo sapiens]                    108   5e-23
gi|21735548 centrosomal protein 2 [Homo sapiens]                      107   1e-22
gi|9910266 kinesin family member 15 [Homo sapiens]                    106   2e-22
gi|31982906 cingulin-like 1 [Homo sapiens]                            105   3e-22
gi|4885583 Rho-associated, coiled-coil containing protein kinase...   104   6e-22
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   103   1e-21
gi|237858619 polyamine modulated factor 1 binding protein 1 isof...   103   1e-21
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   103   1e-21
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...   102   2e-21
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]    102   2e-21
gi|71061468 centromere protein E [Homo sapiens]                       102   4e-21
gi|118498356 kinectin 1 isoform a [Homo sapiens]                      101   5e-21
gi|118498368 kinectin 1 isoform c [Homo sapiens]                      101   5e-21

>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
            sapiens]
          Length = 1591

 Score = 3112 bits (8067), Expect = 0.0
 Identities = 1591/1591 (100%), Positives = 1591/1591 (100%)

Query: 1    MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVC 60
            MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVC
Sbjct: 1    MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVC 60

Query: 61   TYSAGTDTNPIFLFNKEMILCDRPPAIPKTTFSTENDMEIKVEESLMMPAVFHTVASRTQ 120
            TYSAGTDTNPIFLFNKEMILCDRPPAIPKTTFSTENDMEIKVEESLMMPAVFHTVASRTQ
Sbjct: 61   TYSAGTDTNPIFLFNKEMILCDRPPAIPKTTFSTENDMEIKVEESLMMPAVFHTVASRTQ 120

Query: 121  LALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQ 180
            LALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQ
Sbjct: 121  LALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQ 180

Query: 181  SIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTEL 240
            SIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTEL
Sbjct: 181  SIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTEL 240

Query: 241  VLSPDMPRTTNESLLTSFPKSVEHVSPDTADAESGKEIRESCQSTVHQQDETTIDTKDGD 300
            VLSPDMPRTTNESLLTSFPKSVEHVSPDTADAESGKEIRESCQSTVHQQDETTIDTKDGD
Sbjct: 241  VLSPDMPRTTNESLLTSFPKSVEHVSPDTADAESGKEIRESCQSTVHQQDETTIDTKDGD 300

Query: 301  LPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMK 360
            LPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMK
Sbjct: 301  LPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMK 360

Query: 361  AIKGLEDRLYALDQMIASCGRLVNEQKELAQGFLANQKRAENLKDASVLPDLCLSHANQL 420
            AIKGLEDRLYALDQMIASCGRLVNEQKELAQGFLANQKRAENLKDASVLPDLCLSHANQL
Sbjct: 361  AIKGLEDRLYALDQMIASCGRLVNEQKELAQGFLANQKRAENLKDASVLPDLCLSHANQL 420

Query: 421  MIMLQNHRKLLDIKQKCTTAKQELANNLHVRLKWCCFVMLHADQDGEKLQALLRLVIELL 480
            MIMLQNHRKLLDIKQKCTTAKQELANNLHVRLKWCCFVMLHADQDGEKLQALLRLVIELL
Sbjct: 421  MIMLQNHRKLLDIKQKCTTAKQELANNLHVRLKWCCFVMLHADQDGEKLQALLRLVIELL 480

Query: 481  ERVKIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKRLYEAEKSKRESFGK 540
            ERVKIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKRLYEAEKSKRESFGK
Sbjct: 481  ERVKIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKRLYEAEKSKRESFGK 540

Query: 541  LFRKSFLRNRLFRGLDSWPPSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVP 600
            LFRKSFLRNRLFRGLDSWPPSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVP
Sbjct: 541  LFRKSFLRNRLFRGLDSWPPSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVP 600

Query: 601  LLCDFEPLHQHVLALHNLVKAAQSLDEMSQTITDLLSEQKASVSQTSPQSASSPRMESTA 660
            LLCDFEPLHQHVLALHNLVKAAQSLDEMSQTITDLLSEQKASVSQTSPQSASSPRMESTA
Sbjct: 601  LLCDFEPLHQHVLALHNLVKAAQSLDEMSQTITDLLSEQKASVSQTSPQSASSPRMESTA 660

Query: 661  GITTTTSPRTPPPLTVQDPLCPAVCPLEELSPDSIDAHTFDFETIPHPNIEQTIHQVSLD 720
            GITTTTSPRTPPPLTVQDPLCPAVCPLEELSPDSIDAHTFDFETIPHPNIEQTIHQVSLD
Sbjct: 661  GITTTTSPRTPPPLTVQDPLCPAVCPLEELSPDSIDAHTFDFETIPHPNIEQTIHQVSLD 720

Query: 721  LDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDT 780
            LDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDT
Sbjct: 721  LDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDT 780

Query: 781  NVCGKEDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCT 840
            NVCGKEDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCT
Sbjct: 781  NVCGKEDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCT 840

Query: 841  AVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELV 900
            AVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELV
Sbjct: 841  AVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELV 900

Query: 901  CLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLE 960
            CLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLE
Sbjct: 901  CLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLE 960

Query: 961  DLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKE 1020
            DLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKE
Sbjct: 961  DLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKE 1020

Query: 1021 NQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEE 1080
            NQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEE
Sbjct: 1021 NQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEE 1080

Query: 1081 SRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISEL 1140
            SRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISEL
Sbjct: 1081 SRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISEL 1140

Query: 1141 ISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQ 1200
            ISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQ
Sbjct: 1141 ISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQ 1200

Query: 1201 QEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKEL 1260
            QEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKEL
Sbjct: 1201 QEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKEL 1260

Query: 1261 LEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNV 1320
            LEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNV
Sbjct: 1261 LEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNV 1320

Query: 1321 RTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLE 1380
            RTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLE
Sbjct: 1321 RTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLE 1380

Query: 1381 EKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMET 1440
            EKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMET
Sbjct: 1381 EKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMET 1440

Query: 1441 SMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEKIAIRD 1500
            SMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEKIAIRD
Sbjct: 1441 SMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEKIAIRD 1500

Query: 1501 FQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESLPALDLKPASGASRRPWVLGKVMEKE 1560
            FQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESLPALDLKPASGASRRPWVLGKVMEKE
Sbjct: 1501 FQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESLPALDLKPASGASRRPWVLGKVMEKE 1560

Query: 1561 YCQAKKAQNRFKVPLGTKFYRVKAVSWNKKV 1591
            YCQAKKAQNRFKVPLGTKFYRVKAVSWNKKV
Sbjct: 1561 YCQAKKAQNRFKVPLGTKFYRVKAVSWNKKV 1591


>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
            sapiens]
          Length = 1594

 Score = 3106 bits (8053), Expect = 0.0
 Identities = 1591/1594 (99%), Positives = 1591/1594 (99%), Gaps = 3/1594 (0%)

Query: 1    MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVC 60
            MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVC
Sbjct: 1    MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVC 60

Query: 61   TYSAGTDTNPIFLFNKEMILCDRPPAIPKTTFSTENDMEIKVEESLMMPAVFHTVASRTQ 120
            TYSAGTDTNPIFLFNKEMILCDRPPAIPKTTFSTENDMEIKVEESLMMPAVFHTVASRTQ
Sbjct: 61   TYSAGTDTNPIFLFNKEMILCDRPPAIPKTTFSTENDMEIKVEESLMMPAVFHTVASRTQ 120

Query: 121  LALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQ 180
            LALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQ
Sbjct: 121  LALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQ 180

Query: 181  SIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTEL 240
            SIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTEL
Sbjct: 181  SIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTEL 240

Query: 241  VLSPDMPRTTNESLLTSFPKSVEHVSPDTADAESGKEIRESCQSTVHQQDETTIDTKDGD 300
            VLSPDMPRTTNESLLTSFPKSVEHVSPDTADAESGKEIRESCQSTVHQQDETTIDTKDGD
Sbjct: 241  VLSPDMPRTTNESLLTSFPKSVEHVSPDTADAESGKEIRESCQSTVHQQDETTIDTKDGD 300

Query: 301  LPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMK 360
            LPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMK
Sbjct: 301  LPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMK 360

Query: 361  AIKGLEDRLYALDQMIASCGRLVNEQKELAQGFLANQKRAENLKDASVLPDLCLSHANQL 420
            AIKGLEDRLYALDQMIASCGRLVNEQKELAQGFLANQKRAENLKDASVLPDLCLSHANQL
Sbjct: 361  AIKGLEDRLYALDQMIASCGRLVNEQKELAQGFLANQKRAENLKDASVLPDLCLSHANQL 420

Query: 421  MIMLQNHRKLLDIKQKCTTAKQELANNLHVRLKWCCFVMLHADQDGEKLQALLRLVIELL 480
            MIMLQNHRKLLDIKQKCTTAKQELANNLHVRLKWCCFVMLHADQDGEKLQALLRLVIELL
Sbjct: 421  MIMLQNHRKLLDIKQKCTTAKQELANNLHVRLKWCCFVMLHADQDGEKLQALLRLVIELL 480

Query: 481  ERVKIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKRLYEAEKSKRESFGK 540
            ERVKIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKRLYEAEKSKRESFGK
Sbjct: 481  ERVKIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKRLYEAEKSKRESFGK 540

Query: 541  LFRKSFLRNRLFRGLDSWPPSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVP 600
            LFRKSFLRNRLFRGLDSWPPSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVP
Sbjct: 541  LFRKSFLRNRLFRGLDSWPPSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVP 600

Query: 601  LLCDFEPLHQHVLALHNLVKAAQSLDEMSQTITDLLSEQKASVSQTSPQSASSPRMESTA 660
            LLCDFEPLHQHVLALHNLVKAAQSLDEMSQTITDLLSEQKASVSQTSPQSASSPRMESTA
Sbjct: 601  LLCDFEPLHQHVLALHNLVKAAQSLDEMSQTITDLLSEQKASVSQTSPQSASSPRMESTA 660

Query: 661  GITTTTSPRTPPPLTVQDPLCPAVCPLEELSPDSIDAHTFDFETIPHPNIEQTIHQVSLD 720
            GITTTTSPRTPPPLTVQDPLCPAVCPLEELSPDSIDAHTFDFETIPHPNIEQTIHQVSLD
Sbjct: 661  GITTTTSPRTPPPLTVQDPLCPAVCPLEELSPDSIDAHTFDFETIPHPNIEQTIHQVSLD 720

Query: 721  LDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDT 780
            LDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDT
Sbjct: 721  LDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDT 780

Query: 781  NVCGKEDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCT 840
            NVCGKEDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCT
Sbjct: 781  NVCGKEDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCT 840

Query: 841  AVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELV 900
            AVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELV
Sbjct: 841  AVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELV 900

Query: 901  CLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLE 960
            CLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLE
Sbjct: 901  CLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLE 960

Query: 961  DLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKE 1020
            DLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKE
Sbjct: 961  DLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKE 1020

Query: 1021 NQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEE 1080
            NQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEE
Sbjct: 1021 NQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEE 1080

Query: 1081 SRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISEL 1140
            SRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISEL
Sbjct: 1081 SRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISEL 1140

Query: 1141 ISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQ 1200
            ISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQ
Sbjct: 1141 ISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQ 1200

Query: 1201 QEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKEL 1260
            QEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKEL
Sbjct: 1201 QEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKEL 1260

Query: 1261 LEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNV 1320
            LEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNV
Sbjct: 1261 LEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNV 1320

Query: 1321 RTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLE 1380
            RTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLE
Sbjct: 1321 RTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLE 1380

Query: 1381 EKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMET 1440
            EKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMET
Sbjct: 1381 EKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMET 1440

Query: 1441 SMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEKIAIRD 1500
            SMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEKIAIRD
Sbjct: 1441 SMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEKIAIRD 1500

Query: 1501 FQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESLPALDLKP---ASGASRRPWVLGKVM 1557
            FQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESLPALDLKP   ASGASRRPWVLGKVM
Sbjct: 1501 FQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESLPALDLKPGEGASGASRRPWVLGKVM 1560

Query: 1558 EKEYCQAKKAQNRFKVPLGTKFYRVKAVSWNKKV 1591
            EKEYCQAKKAQNRFKVPLGTKFYRVKAVSWNKKV
Sbjct: 1561 EKEYCQAKKAQNRFKVPLGTKFYRVKAVSWNKKV 1594


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  122 bits (307), Expect = 2e-27
 Identities = 184/813 (22%), Positives = 366/813 (45%), Gaps = 106/813 (13%)

Query: 792  TSLNVQLERCRVVAQDSHFSIQTIKEDLCH---FRTFVQKEQCDFSNSLKCTAVEIRNII 848
            ++L   ++    V  +S   ++  KE+L      R   Q E   F   L  T  E   ++
Sbjct: 2036 SALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVL 2095

Query: 849  -EKVKCSLEITLKEKHQKELLSLKNE-YEGKLDGL----IKETEENENKIKKLKGELVCL 902
             + +K   E+   ++  K  +  K+E  E +L+      +KE +  + K+  L+ E V L
Sbjct: 2096 ADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHL 2155

Query: 903  EEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDL 962
            EE +   + +  L K +KE V  LQ   D  + ++     S +     L+  R+ V+++ 
Sbjct: 2156 EETIG--EIQVTLNKKDKE-VQQLQENLDSTVTQLAAFTKSMS----SLQDDRDRVIDEA 2208

Query: 963  KKLHVENDEKLQLLRAELQSLEQS-------------HLKELEDTL-QVRHIQEFEKVMT 1008
            KK   +  + +Q    E++  E +             H++EL+  + ++ H ++  +   
Sbjct: 2209 KKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKA 2268

Query: 1009 DHRVSLEE-----LKKENQQIINQIQE------SHAEIIQEKEKQLQELKLKVSDLSDT- 1056
               V L++     L+ EN+++++Q++E      S    + + E +L+ LK +++DLS++ 
Sbjct: 2269 QTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSL 2328

Query: 1057 -RCK-----LEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQK 1110
             +CK     LE  +  +EA+    K   E     Q ET      + T  L  EI+   QK
Sbjct: 2329 EKCKEQKGNLEGIIRQQEADIQNSKFSYE-----QLETDLQASRELTSRLHEEINMKEQK 2383

Query: 1111 I----QDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAF 1166
            I        E  QV +AELR     E  + +  L+S+ EEE+ +L+ E  K     NQ  
Sbjct: 2384 IISLLSGKEEAIQVAIAELRQQHDKEIKE-LENLLSQEEEENIVLEEENKKAVDKTNQLM 2442

Query: 1167 EIEKNLKEQIIELQSKLDS---ELSALERQKDEKI---TQQEEKYEAIIQNLEKDRQKLV 1220
            E  K +K++ I+ +++LDS    +S+L+  +D  +    Q EE++ +II  LEKD  +L+
Sbjct: 2443 ETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSII--LEKD--QLI 2498

Query: 1221 SSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVE-KELLEKV---------KHLENQ 1270
                 +  +L +++   +        +  KL+ E+++ +E L +V         + LE Q
Sbjct: 2499 QEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQ 2558

Query: 1271 IAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQT 1330
            + ++  +++        + E  E+  E+  +    L+E+++  ++E+++++ S+   Q T
Sbjct: 2559 LQQNKELENKYAKLEEKLKE-SEEANEDLRRSFNALQEEKQDLSKEIESLKVSI--SQLT 2615

Query: 1331 NFNTVLTREKMR---------KENIINDLSDKLKSTMQQ-QERDKDLIESLSEDRARLLE 1380
               T L  E            KE  ++ LS    S+ ++  E +++L+    E   ++ E
Sbjct: 2616 RQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGE 2675

Query: 1381 EKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMET 1440
             + KL++E+  L   + +      TA E     A +L     +  + T +   + + +++
Sbjct: 2676 IEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQS 2735

Query: 1441 ---SMMSVQENIHMLSEEKQRI-----MLLERTLQLKEEE-NKRLNQRLMSQSMSSVSS- 1490
               SM S+Q +    +EE   +       L+   QLKE+    R    L+S++  S++S 
Sbjct: 2736 FGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNST 2795

Query: 1491 -----RHSEKIAIRDFQVGDLVLIILDERHDNY 1518
                  H EK+  +     + +L +  +  D+Y
Sbjct: 2796 EENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSY 2828



 Score =  109 bits (272), Expect = 2e-23
 Identities = 163/690 (23%), Positives = 310/690 (44%), Gaps = 94/690 (13%)

Query: 775  RRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQ---------DSHFSIQTIKEDLCHFR-T 824
            R++Q   +  KE   ++ SL  +L   R   +         +S  S Q  ++D    R  
Sbjct: 1483 RKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLA 1542

Query: 825  FVQKEQCDFSNSLKCTAVEIRNI---IEKVKCSLEITL--KEKHQKELLSLKNEYEGKLD 879
             +Q+E+      +  + +E +++    E +K +LE     KEK  KE+ SLK+       
Sbjct: 1543 LLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK----- 1597

Query: 880  GLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMEN 939
              I E+ E + K K+L+ E   L +  +N  NE   ++H  EAV   + E   KL   E 
Sbjct: 1598 --IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEA 1655

Query: 940  IMHSQNCEIKELKQSREIVLEDLKKLH-------VENDEKLQLLRAELQSLEQSHLKELE 992
                   +++E +Q  E + E ++K         +E +E+   LRAE+     +  KE  
Sbjct: 1656 NKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDT-AKECM 1714

Query: 993  DTLQVRHI---QEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQ----- 1044
            +TL   +    +E E+V    ++  E L K+ Q ++++ ++S +E +Q+ + Q++     
Sbjct: 1715 ETLLSSNASMKEELERV----KMEYETLSKKFQSLMSE-KDSLSEEVQDLKHQIEGNVSK 1769

Query: 1045 ELKLKVSDLSDTRCKLEVELALK-EAETDEIKILLEESRAQQKETLKSLLE--------- 1094
            +  L+ ++  D +  +  E       ET+E   L   +R    E++ S            
Sbjct: 1770 QANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDF 1829

Query: 1095 ----------QETENLRTEISKLNQKIQDNNENYQVGLAELRTLMT--IEKD---QCISE 1139
                      Q+ + L+  I+ L ++ Q N E  Q    E  TL++    KD   + + E
Sbjct: 1830 SSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQE 1889

Query: 1140 LISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKIT 1199
             +++    +  ++ EL++VT L   A E + +L+E+++   ++L+  +        + +T
Sbjct: 1890 EVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIG----NYCQDVT 1945

Query: 1200 QQEEKYEAIIQNLEKDRQKLVSSQEQDREQLI-QKLNCEKD------EAIQTALKE---- 1248
              + K E ++++  K+ +K VS  E++++QL+ +K   E +      E IQ A KE    
Sbjct: 1946 DAQIKNE-LLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNK 2004

Query: 1249 -FKLEREVVEKELLEKVKHLENQI----AKSPAIDSTRGDSSSLVAELQEKLQEEKAKFL 1303
                E + + KE  ++VK L+        K  A++ T      +  E Q+ L+  K   L
Sbjct: 2005 SHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKEN-L 2063

Query: 1304 EQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQER 1363
             Q  E  K+   E+ + +  L   Q      +    K++KE  +    + +KS M+Q  +
Sbjct: 2064 AQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKE--LQSNKESVKSQMKQ--K 2119

Query: 1364 DKDLIESLSEDRARLLEEKKKLEEEVSKLR 1393
            D+DL   L +   + L+EKK ++E++  LR
Sbjct: 2120 DEDLERRLEQAEEKHLKEKKNMQEKLDALR 2149



 Score = 98.2 bits (243), Expect = 6e-20
 Identities = 180/841 (21%), Positives = 340/841 (40%), Gaps = 185/841 (21%)

Query: 811  SIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCS--------LEITLKE- 861
            S+ ++++D        +K +  FS++++    EIR  +++  CS        + I ++E 
Sbjct: 2193 SMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR--LKEDNCSVLKDQLRQMSIHMEEL 2250

Query: 862  -------KHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFA 914
                   +H K++   K + E +L   + +T + ENK  +L  +L     +  +  NE A
Sbjct: 2251 KINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENK--ELLSQLEETRHLYHSSQNELA 2308

Query: 915  LVKHE----KEAVICLQNE----KDQKLLEMENIMHSQNCEIKELKQSREIVLEDLK--- 963
             ++ E    K+ +  L N     K+QK   +E I+  Q  +I+  K S E +  DL+   
Sbjct: 2309 KLESELKSLKDQLTDLSNSLEKCKEQKG-NLEGIIRQQEADIQNSKFSYEQLETDLQASR 2367

Query: 964  ----KLHVE--------------NDEKLQLLRAELQSLEQSHLKELEDTLQVRH-----I 1000
                +LH E               +E +Q+  AEL+      +KELE+ L         +
Sbjct: 2368 ELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVL 2427

Query: 1001 QEFEKVMTDHRVSLEE----LKKENQQI------------------------INQIQESH 1032
            +E  K   D    L E    +KKEN Q                           Q++E H
Sbjct: 2428 EEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERH 2487

Query: 1033 AEIIQEKEKQLQE--------------LKLKVSDLSDTRCKLEVELALKEAETDEI---- 1074
              II EK++ +QE              L+  + DL+    KL+ EL     + +++    
Sbjct: 2488 LSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIK 2547

Query: 1075 ----KILLEESRAQQKET------LKSLL---EQETENLRTEISKLNQKIQDNN---ENY 1118
                K LLE    Q KE       L+  L   E+  E+LR   + L ++ QD +   E+ 
Sbjct: 2548 DSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESL 2607

Query: 1119 QVGLAELRTLMTIEKDQCISEL----ISRHEEE----SNILKAELNKVTSLHNQAFEIEK 1170
            +V +++L   +T  +++    L    +   EEE    S +  +   ++  L  +   ++K
Sbjct: 2608 KVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQK 2667

Query: 1171 NLKEQIIELQSKLDSELSALERQKD---EKITQQEEKYEAIIQNLEKDRQKLV------- 1220
               +++ E++ KL  EL  L         +    EE+   + ++L +  QKL+       
Sbjct: 2668 EAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENK 2727

Query: 1221 --SSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAID 1278
              ++Q Q   + +  L   +D A +  L E K + +   KEL         Q+ +   ++
Sbjct: 2728 GLTAQIQSFGRSMSSLQNSRDHANEE-LDELKRKYDASLKELA--------QLKEQGLLN 2778

Query: 1279 STRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSL--IAEQQTNFNTVL 1336
              R    S  A      +E     LE+L +Q   K+E++ ++ + L     Q  +F+  +
Sbjct: 2779 RERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAM 2838

Query: 1337 TREKMRKENIINDLSDKLKSTMQQQERD--------------KDLIESLSEDRARLLEEK 1382
               +  ++++ N+L +K + + + ++R               K  + SL  DR RLL+E 
Sbjct: 2839 ASLQNERDHLWNEL-EKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKEL 2897

Query: 1383 KKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSM 1442
            K L+++  ++        P  A   E           +    A +   E      +    
Sbjct: 2898 KNLQQQYLQINQEITELHPLKAQLQEY----------QDKTKAFQIMQE-----ELRQEN 2942

Query: 1443 MSVQENIHMLSEEKQRIMLLERTLQLK-----EEENKRLN--QRLMSQSMSSVSSRHSEK 1495
            +S Q  +H L  EK    + ER ++ +      +++++L+  Q L+ +  SS S     K
Sbjct: 2943 LSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLK 3002

Query: 1496 I 1496
            +
Sbjct: 3003 V 3003



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 158/726 (21%), Positives = 308/726 (42%), Gaps = 94/726 (12%)

Query: 830  QC--DFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSL-------KNEYEGKLDG 880
            QC  D    LK   +E+     K +   E  L EK  KE+ +L       K   +     
Sbjct: 680  QCHQDELERLKSQILELELNFHKAQEIYEKNLDEK-AKEISNLNQLIEEFKKNADNNSSA 738

Query: 881  LIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENI 940
                +EE +  + ++K   +  E   Q K  E  L + E++  +  +++     L  E I
Sbjct: 739  FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQI 798

Query: 941  MHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHI 1000
             HS + E K      E++  +L  + ++  E+  L+R+    L+    + LE   +VRHI
Sbjct: 799  -HSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHI 857

Query: 1001 ----QEFEKVMTDHRV---SLEELKKENQQIINQIQESHAEIIQEKEKQLQELKL----K 1049
                +E  + ++   +    +++L  E ++ +  +Q++    I+EK++Q+ E+      K
Sbjct: 858  SSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQT----IEEKDQQVTEISFSMTEK 913

Query: 1050 VSDLSDTRCKLEVEL-ALKE----------------AETDEIKILLEESRAQQK---ETL 1089
            +  L++ +  L VE+  LKE                 E +E+   L+++  +     +  
Sbjct: 914  MVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQIS 973

Query: 1090 KSLLEQETENLRTEISKLNQKIQD---NNENYQVGLAELRTLMTIEKDQCISELISRHEE 1146
            K  L+ E + L+ E  +  +K+Q    N +     ++ L   +   KD+   E+     E
Sbjct: 974  KEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETE 1033

Query: 1147 ESNILKAELNKVTS---LHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEE 1203
               + + + NK  S   + ++  EIE  LK+ I    S+ + EL  + +  +EK+   EE
Sbjct: 1034 RGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTI----SEKEVELQHIRKDLEEKLA-AEE 1088

Query: 1204 KYEAIIQNLEKDRQ------KLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVE 1257
            +++A+++ + +  Q       L+ ++  + + +IQKL     +A          E  V+ 
Sbjct: 1089 QFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVIS 1148

Query: 1258 KELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEM 1317
                   +H + ++ +   I +   +   L  +LQE L   KA  L++ +E+E+   EE+
Sbjct: 1149 PPCTGSSEHWKPELEEK--ILALEKEKEQLQKKLQEALTSRKA-ILKKAQEKERHLREEL 1205

Query: 1318 QNVRTSLIAEQQTNFNTVLTR-EKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRA 1376
            +        +Q+ ++N +  + ++  KEN   ++ D+L+  +Q Q R+    +  S D+ 
Sbjct: 1206 K--------QQKDDYNRLQEQFDEQSKEN--ENIGDQLRQ-LQIQVRESIDGKLPSTDQQ 1254

Query: 1377 RLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGES-DRSAVETADEGRVD 1435
                    LEE + K             T P L     P+ P  S D SA++        
Sbjct: 1255 ESCSSTPGLEEPLFKATEQHH-------TQPVLESNLCPDWPSHSEDASALQGGTSVAQI 1307

Query: 1436 SAM--ETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSR-- 1491
             A   E     V+  + + S   +     E   QL+E+ NK   Q L  +S+ +VS    
Sbjct: 1308 KAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINK---QGLEIESLKTVSHEAE 1364

Query: 1492 -HSEKI 1496
             H+E +
Sbjct: 1365 VHAESL 1370



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 144/706 (20%), Positives = 319/706 (45%), Gaps = 117/706 (16%)

Query: 827  QKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETE 886
            Q+   +F+N+ +    E     E++   L+  +++K          + + K + L +E +
Sbjct: 36   QESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDV--------QLQQKDEALQEERK 87

Query: 887  ENENKIKKL----KGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMH 942
              +NKIKKL    K +L  L + ++        +K +   V+  + + +++L + +    
Sbjct: 88   AADNKIKKLKLHAKAKLTSLNKYIEE-------MKAQGGTVLPTEPQSEEQLSKHDKSST 140

Query: 943  SQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQE 1002
             +  EI+++K   +      +K  + +  + QL +A+ +   QS  +  E  +  + +QE
Sbjct: 141  EEEMEIEKIKHKLQ------EKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQE 194

Query: 1003 FEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQ-ELKLKVSDLSDTRCKLE 1061
             E+ ++  +  L +          Q +++  ++++EK+ + + +++L   +L     + +
Sbjct: 195  KEEFISTLQAQLSQ---------TQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQAD 245

Query: 1062 VELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVG 1121
            VE  +++      K+ + + + ++ E       Q  + L+ E++   Q+ Q  ++  Q  
Sbjct: 246  VETEMQQ------KLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQM 299

Query: 1122 LAELRTLM-TIEKDQCISELISRHEEESNIL--KAEL---NKVTSLHNQAFEIEKNLK-- 1173
             AE  TL  T+E ++          EES IL  K EL    +  S HN   E+   L+  
Sbjct: 300  EAEHNTLRNTVETER----------EESKILLEKMELEVAERKLSFHNLQEEMHHLLEQF 349

Query: 1174 EQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQK 1233
            EQ  + Q++L+S  SALE++      + EEK   I+ +L+K  Q+L S+ +  ++Q  + 
Sbjct: 350  EQAGQAQAELESRYSALEQKHK---AEMEEKTSHIL-SLQKTGQELQSACDALKDQNSKL 405

Query: 1234 LNCEKDEAIQTALKEFKLEREVVEK-----ELLEKVKHLENQIAKSPAI-----DSTRGD 1283
            L  + ++A+Q+A    +LE ++ +K     + L ++   +++ A   +      + T+  
Sbjct: 406  LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAV 465

Query: 1284 SSSLVAELQEKL----QEEKAKFLEQLE-EQEKRKNEEMQNVRTSLIAEQQTNFNTVLTR 1338
            +   +A LQ+++     E+ A  L  +E E+ K +NE++ +  T L A+ +T        
Sbjct: 466  TEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTG-----EA 520

Query: 1339 EKMRKENIINDLSDKLKSTMQQQERD--KDLIESLSEDRARLLEEKKKLEEEVSKLRSSS 1396
            ++   E  I D+++K  S+ ++  +D  ++      ++ + LL E K+ +EE++ L+   
Sbjct: 521  DREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKL-- 578

Query: 1397 FVPSPYVATAPELYGACAPELPGE--SDRSAVETADEGRVDSAMETSMMSVQENIHMLSE 1454
                       +L G  A E   E    +   +   EG     M+  +    ++  ++  
Sbjct: 579  -----------QLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPN 627

Query: 1455 EKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEKIAIRD 1500
            E+  +  +E+                  Q+ +   SR SE+I++ D
Sbjct: 628  EESSLPAVEK-----------------EQASTEHQSRTSEEISLND 656



 Score = 88.6 bits (218), Expect = 4e-17
 Identities = 160/726 (22%), Positives = 296/726 (40%), Gaps = 137/726 (18%)

Query: 871  KNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNK---DNEFALVKHEKEAVICL- 926
            K E + + D L KE   NE + +KL+  L+  +E+LQ     + E A +K E +  I L 
Sbjct: 974  KEELQHEFDLLKKE---NEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLS 1030

Query: 927  QNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQS 986
            + E+ +   + EN  +S+ C   + ++    + + + +  VE     + L  +L + EQ 
Sbjct: 1031 ETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQF 1090

Query: 987  H--LKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQ 1044
               +K++  TLQ +         T+    L+    ENQ II ++  S+ +        L 
Sbjct: 1091 QALVKQMNQTLQDK---------TNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALV 1141

Query: 1045 ELKLKVS-----DLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETEN 1099
            +  + +S          + +LE ++   E E ++++  L+E+   +K  LK   E+E  +
Sbjct: 1142 KETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKE-RH 1200

Query: 1100 LRTEI-------SKLNQKIQDNN-ENYQVGLAELRTLMTIEKDQCISELISRHEEESNI- 1150
            LR E+       ++L ++  + + EN  +G  +LR L    ++    +L S  ++ES   
Sbjct: 1201 LREELKQQKDDYNRLQEQFDEQSKENENIG-DQLRQLQIQVRESIDGKLPSTDQQESCSS 1259

Query: 1151 ---LKAELNKVTSLHNQAFEIEKNL-----------------------KEQI-------I 1177
               L+  L K T  H+    +E NL                       K Q+       +
Sbjct: 1260 TPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKV 1319

Query: 1178 ELQSKLDSELSALERQKDEKITQQEE--------------------KYEAIIQNLEKDR- 1216
            EL+ K+ S  S L ++ +E    QE+                      E++ Q LE  + 
Sbjct: 1320 ELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQL 1379

Query: 1217 ------------------QKLVSSQEQDREQLIQKLNCEKDEAI----------QTALKE 1248
                              QKL+S +E+D   L  +L+ EK+ A+          +  +K 
Sbjct: 1380 QIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLS-EKEAALTKIQTEIIEQEDLIKA 1438

Query: 1249 FKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEE 1308
               + E+  KE  E++K L+ ++ +        G+ S    ++Q KLQ       E L+E
Sbjct: 1439 LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKE 1498

Query: 1309 QEKRKNEEMQNVRTSL-------------IAEQQTNFNTVLTREKMRKENIINDLSDKLK 1355
              K   EE+   R ++             ++ Q    +TVL R  + +E     +++  +
Sbjct: 1499 N-KSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDR 1557

Query: 1356 STMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPS-PYVATAPELYGACA 1414
            S ++ Q       ESL      L E+K+KL +E+  L+SS    S  +     EL     
Sbjct: 1558 SLLENQSLSSSC-ESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEY- 1615

Query: 1415 PELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENK 1474
             E+  +S  +    A+  R+   +E      QE    L   +      E+ LQ  E+E +
Sbjct: 1616 -EILLQSYENVSNEAE--RIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEME 1672

Query: 1475 RLNQRL 1480
             + +++
Sbjct: 1673 EMKEKM 1678



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 154/805 (19%), Positives = 335/805 (41%), Gaps = 73/805 (9%)

Query: 726  ESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDTNVCGK 785
            E  E+  +   N+  +++       +   +   +  ++   S + ++ S +     + G 
Sbjct: 2420 EEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGD 2479

Query: 786  EDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIR 845
                +   L++ LE+ +++ Q++      +KE++   R+ +     + +  L    ++ R
Sbjct: 2480 YQQLEERHLSIILEKDQLI-QEAAAENNKLKEEIRGLRSHMDDLNSE-NAKLDAELIQYR 2537

Query: 846  NIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEV 905
              + +V     IT+K+  QK+LL ++          +++ +E ENK  KL+ +L   EE 
Sbjct: 2538 EDLNQV-----ITIKDSQQKQLLEVQ----------LQQNKELENKYAKLEEKLKESEEA 2582

Query: 906  LQNKDNEFALVKHEKE---------AVICLQNEKDQKLLEMENIMHSQNCEIKELKQSRE 956
             ++    F  ++ EK+          V   Q  +    L+ E  +   + ++K     +E
Sbjct: 2583 NEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKV----KE 2638

Query: 957  IVLEDLKKLHVENDEKLQLLRAELQSLEQSHLK---ELEDTL--QVRHIQEFEKVMTDHR 1011
              +  L  L   + +++  L  EL  +++   K   E+ED L  +++H+     +M +  
Sbjct: 2639 EEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNET 2698

Query: 1012 VSLEELKKENQQIINQIQESHAEIIQEKE---KQLQELKLKVSDLSDTR---------CK 1059
             + EE   E  + + ++++    + +E +    Q+Q     +S L ++R          K
Sbjct: 2699 ETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELK 2758

Query: 1060 LEVELALKE-AETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENY 1118
             + + +LKE A+  E  +L  E  A   ET  S+   E EN  + + KLNQ++   +E  
Sbjct: 2759 RKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTE-ENSLSHLEKLNQQLLSKDEQL 2817

Query: 1119 QVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIE 1178
                ++L    +  + Q  S+ ++  + E + L  EL K                    E
Sbjct: 2818 LHLSSQLED--SYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAE 2875

Query: 1179 LQSKLDSELSALERQKD---EKITQQEEKYEAIIQNLEKDRQKLVSSQE-QDRE---QLI 1231
            +QS L   +S+L+  +D   +++   +++Y  I Q + +        QE QD+    Q++
Sbjct: 2876 VQS-LKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIM 2934

Query: 1232 QKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAEL 1291
            Q+   +++ + Q  L + ++E+   E   + + +  E  +      D       +L+ EL
Sbjct: 2935 QEELRQENLSWQHELHQLRMEKSSWE---IHERRMKEQYLMAISDKDQQLSHLQNLIREL 2991

Query: 1292 QE---KLQEEKAKFLEQLEEQEKRKNEEMQNV--RTSLIAEQQTNFNTVLTREKMRKENI 1346
            +    + Q  K ++  Q   +     +  QN+   T L+  Q  +    + ++++R + +
Sbjct: 2992 RSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQL 3051

Query: 1347 INDLSDKLKSTMQQQERDKDLIESLSEDRAR---LLEEKKKLEEEVSKLRSSSFVPSPYV 1403
             ++ S  L+       +  D  +SL E++     LL     LE++V +L++         
Sbjct: 3052 NSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAP 3111

Query: 1404 ATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLE 1463
                E  G      P E  R   ++  E +    +  +   V E   +L EE+ + +  E
Sbjct: 3112 GAPQEKNGVHRKSDPEEL-REPQQSFSEAQ--QQLCNTRQEVNELRKLLEEERDQRVAAE 3168

Query: 1464 RTLQLKEEENKRLNQRLMSQSMSSV 1488
              L + EE+ +RL       S + +
Sbjct: 3169 NALSVAEEQIRRLEHSEWDSSRTPI 3193



 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 160/806 (19%), Positives = 358/806 (44%), Gaps = 110/806 (13%)

Query: 846  NIIEKVK--CSLEITLKEKHQKEL-------LSLKNEYEGKLDGLIKETEENENKIKKLK 896
            N I+K+K     ++T   K+ +E+       L  + + E +L    K + E E +I+K+K
Sbjct: 91   NKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIK 150

Query: 897  GELVCLEEVLQNKDNEFALVKHEKEAVICLQNEK----DQKLLEMENIMHSQNCEIKEL- 951
             +L   EE++     +    + E+ A    + E+     Q+L E E  + +   ++ +  
Sbjct: 151  HKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQ 210

Query: 952  --KQSREIVLE-DLK---KLHVENDEKLQLL-RAELQSLEQSHLKELEDTLQVRHIQEFE 1004
              + ++++V E D +   ++ +  DE LQL+ +A++++  Q  L+ L+     R ++E E
Sbjct: 211  AEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQ-----RKLEEHE 265

Query: 1005 KVMTDHRVSLEELKKE-------NQQIINQIQESHAE-------IIQEKEKQ---LQELK 1047
            + +      ++ L++E       NQ +  Q+Q+  AE       +  E+E+    L++++
Sbjct: 266  ESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKME 325

Query: 1048 LKVSD--LSDTRCKLEVELALKEAE-TDEIKILLEESRAQQKETLKSLLEQETENLRTEI 1104
            L+V++  LS    + E+   L++ E   + +  LE   +  ++  K+ +E++T ++   +
Sbjct: 326  LEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHI-LSL 384

Query: 1105 SKLNQKIQ---DNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKV--- 1158
             K  Q++Q   D  ++    L + +    ++  Q I +L  + +++S  +   LN++   
Sbjct: 385  QKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQ 444

Query: 1159 ----------TSLHNQAFE--IEKN---LKEQIIELQSKLDS-ELSALE----RQKDEKI 1198
                        ++N+  +   E+N   L+++++EL+++  +  LS++E    + ++EK+
Sbjct: 445  QHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKL 504

Query: 1199 TQQEEKYEAIIQNLEKDRQ-----------KLVSSQEQDREQLIQKLNCEKDEAIQTALK 1247
            + Q    EA  +  E DR+           K  SS E+  + +++    +K + +   L 
Sbjct: 505  SSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLL 564

Query: 1248 EFKLEREVVEKELLE----KVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFL 1303
            E K  +E +    L+    + +  ++++     +    G+    +A ++ K+      FL
Sbjct: 565  EMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEG---IAPIKMKV------FL 615

Query: 1304 EQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQER 1363
            E   +        M N  +SL A ++   +T   + +  +E  +ND   +LKST Q  ++
Sbjct: 616  EDTGQDFPL----MPNEESSLPAVEKEQASTE-HQSRTSEEISLNDAGVELKSTKQDGDK 670

Query: 1364 DKDLIESLSEDRARLLEEKKK--LEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGES 1421
                +  + +     LE  K   LE E++  ++           A E+  +   +L  E 
Sbjct: 671  SLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEI--SNLNQLIEEF 728

Query: 1422 DRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLM 1481
             ++A   +      S     ++S  + + M++E + ++  LE  L  + E  +RL+    
Sbjct: 729  KKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNL-AEAERQRRLDYESQ 787

Query: 1482 SQSMSSVSSR-HSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESLPALDL 1540
            +   + ++ + HS  I  +   V   + ++ +E  D  + F+   TL       L   + 
Sbjct: 788  TAHDNLLTEQIHSLSIEAKSKDV--KIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKES 845

Query: 1541 KPASGASRRPWVLGKVMEKEYCQAKK 1566
            +   GA R   +  KV E     ++K
Sbjct: 846  EVLEGAERVRHISSKVEELSQALSQK 871


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score =  119 bits (298), Expect = 2e-26
 Identities = 174/783 (22%), Positives = 348/783 (44%), Gaps = 115/783 (14%)

Query: 797  QLERCRVVAQDSHFS-----IQTIKEDLCHFRTFVQKEQC--DFSNSLKCTAVEIRNIIE 849
            QL+    +   +H S     +Q  ++ L H +   +++    D+    +   ++I  + E
Sbjct: 244  QLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQE 303

Query: 850  KVKCSLEITLKEKHQKELLSLKNEYEGK---LDGLIKETEENENKIKKLKGELVCLEEVL 906
            K+K    +   E+ +K   S K E + K   ++ L  +  E E K  +LK +L   +++L
Sbjct: 304  KIK----VYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLL 359

Query: 907  QNKDNEFALVKHE-KEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSR----EIVLED 961
                 +      E K   + L N K ++    E I       ++EL++      +   + 
Sbjct: 360  GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGT-VEELQKRNHKDSQFETDI 418

Query: 962  LKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEE-LKKE 1020
            ++++  E   KL+ LRAEL  +    + +++  L  +H+ + E++ T H+  +E  L+  
Sbjct: 419  VQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY 478

Query: 1021 NQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELAL----KEAETDEIKI 1076
            +   +N+ Q      I+     + EL +K+ D +  + KL+ EL L    K A   +++ 
Sbjct: 479  SNITVNEDQ------IKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLED 532

Query: 1077 LLEE---SRAQQKETLKSLLEQET------------ENLRTEI-------SKLNQKIQDN 1114
            L+EE   SR Q +   +++ EQE+            E+L+ EI        +L  K +  
Sbjct: 533  LVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAE 592

Query: 1115 NENYQVGLAELR-----------TLMTIEKDQCISELISRHEEESNILKAELNKVTSLHN 1163
              NY++ L  L                 E ++  ++L+  HEEE + LK +L     ++ 
Sbjct: 593  VTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINI 652

Query: 1164 QAFEIEKNL----KEQIIELQSKLDSELSALERQKDEKITQQEE------KYEAIIQNLE 1213
            +  +++ NL    K+QI  LQ+++  ++  ++ +KD  IT+Q +      K + + Q+L 
Sbjct: 653  E--KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV 710

Query: 1214 KDRQKLVSSQEQDREQLIQKLNCEKDE--AIQTALKEFKLEREVVEKELLEKVKHLENQI 1271
              + + ++ Q  + ++ I+ L  E+ E   ++  ++E +L+ E++EK++ EK   L+ + 
Sbjct: 711  NSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKF 770

Query: 1272 AKSPAIDSTRGDSSSLVAELQE----KLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAE 1327
            A+  A +S   D    + ++ +      QEE+  FL+ ++ + K   + +      ++ E
Sbjct: 771  AQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSK---DSVWEKEIEILIE 827

Query: 1328 QQTNFNTVLTREKMRKENI-INDLSDKLKSTMQQQERDKDL-IESLSEDRARLLEEKKKL 1385
            +          E ++++ I +N+  +K ++T    E++ ++  + L E+ A LL+ K  L
Sbjct: 828  E---------NEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL 878

Query: 1386 EEEVSKLRSSSFVPSPYVATAPELY--------GACAPELPGESDRSAVETADEGRVDSA 1437
            E+  SK +      S   A   EL+              +  E      ET + G V   
Sbjct: 879  ED--SKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEV--- 933

Query: 1438 METSMMSVQENIHMLSEEK----QRIMLLERTLQLKEEENKRLNQRLMS--QSMSSVSSR 1491
            +E     + E + +   EK    QR+  L   L+ K  E   LN+ + S  Q    VS R
Sbjct: 934  VEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLR 993

Query: 1492 HSE 1494
              E
Sbjct: 994  CRE 996



 Score = 97.8 bits (242), Expect = 7e-20
 Identities = 143/689 (20%), Positives = 308/689 (44%), Gaps = 95/689 (13%)

Query: 794  LNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKC 853
            +NV +    +  QD++   + +KE+L      + +E+C     L+       +++E++  
Sbjct: 491  MNVAINELNIKLQDTNSQKEKLKEEL----GLILEEKCALQRQLE-------DLVEELSF 539

Query: 854  SLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEF 913
            S     +E+ Q+   ++  E E KL+    E  ++ + ++ LK E+V   E    K+ E 
Sbjct: 540  S-----REQIQRARQTIA-EQESKLN----EAHKSLSTVEDLKAEIVSASE--SRKELE- 586

Query: 914  ALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLK-KLHVENDEK 972
              +KHE E      N K    +++E +   +N  +  + +S+E  LE L+ +L   ++E+
Sbjct: 587  --LKHEAEVT----NYK----IKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEE 636

Query: 973  LQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESH 1032
            L  L+ +L+   + ++++L+D L + + Q+ + +  +    +E ++ E   +I +  +  
Sbjct: 637  LSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI 696

Query: 1033 AEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSL 1092
             EI + K+ Q   +  K  +++         L + E +  EI+IL      +Q+E  K  
Sbjct: 697  LEISKLKDLQQSLVNSKSEEMT---------LQINELQK-EIEIL------RQEEKEKGT 740

Query: 1093 LEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQ--CISELISRHEEESNI 1150
            LEQE + L+ +   L +++++   + Q   A+L    +I KD+   + +++  H   S  
Sbjct: 741  LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVS-- 798

Query: 1151 LKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQ 1210
               +  ++  L +   + + ++ E+ IE+  + + +L     Q +E+I +Q   +    +
Sbjct: 799  ---QEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEK 855

Query: 1211 NLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKEL-LEKVKHLEN 1269
            N E + Q+L     Q+    + K+  + +++      E+K + + + +EL L+++     
Sbjct: 856  NFEVNYQEL-----QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTV 910

Query: 1270 QIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQ 1329
            ++ KS   D    +  + VAE            LE  E  EK   E M+ +         
Sbjct: 911  KM-KSSVFD----EDKTFVAET-----------LEMGEVVEKDTTELMEKLE-------- 946

Query: 1330 TNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEV 1389
                 V  REK+     ++DLS++LK    +     + ++SL +++ ++    ++LE  +
Sbjct: 947  -----VTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIII 1001

Query: 1390 SKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENI 1449
            +  R+ + V S     +  L G       G     +      G     M    +S  EN+
Sbjct: 1002 NHNRAEN-VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSF-ENM 1059

Query: 1450 HMLSEEKQRIMLLERTLQLKEEENKRLNQ 1478
             +  E KQ  ++L+    + +E + R  Q
Sbjct: 1060 TVGEESKQEQLILDHLPSVTKESSLRATQ 1088



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 143/641 (22%), Positives = 279/641 (43%), Gaps = 145/641 (22%)

Query: 849  EKVKCSLEITLK---EKHQKELLSLK-NEYEGKLDGLIKET-------EENENKIKKLKG 897
            E +KC  E+  +   E   +E L+++ ++ EG +DG   E        +E  + I +L+ 
Sbjct: 1891 ESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQ 1950

Query: 898  ELVC-------LEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIK- 949
            EL+C       LE   Q    E  L+  +KEA+       +Q+LL+    +  +  E++ 
Sbjct: 1951 ELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQC 2010

Query: 950  ----------------------------ELKQSREIVLEDLKKLHVENDEKLQLLRAEL- 980
                                        EL+Q +   L DL++ +   +++L+ +R  L 
Sbjct: 2011 QAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLD 2070

Query: 981  -QSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEI---- 1035
             Q++++ H +++    +++ +++  KV+   +   E   +E +Q+ N ++E   +     
Sbjct: 2071 EQAIDREHERDVFQQ-EIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129

Query: 1036 ---------IQEKEKQLQELKLKVSDL-------SDTRCKLE--VELALKEAETD---EI 1074
                     IQE+ +++++L+ +V +L       +DT  K+E        EA+ +   E+
Sbjct: 2130 LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEV 2189

Query: 1075 KILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRT-LMTIEK 1133
            ++  E     +KE   + LE++ E  R E+   N+++Q  +   ++   E  T L  +E+
Sbjct: 2190 QLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQ 2249

Query: 1134 DQ------------CISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQS 1181
            +              I E  +   ++ ++L  +  ++  +  +  EI++ L EQ+ +LQ 
Sbjct: 2250 ENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI--IQEKEVEIDQ-LNEQVTKLQQ 2306

Query: 1182 KLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQE---QDREQLIQKLNCEK 1238
            +       L+   D K+   EEK E +I++LE   + L+S QE   ++RE+ I++LN E 
Sbjct: 2307 Q-------LKITTDNKVI--EEKNE-LIRDLETQIECLMSDQECVKRNREEEIEQLN-EV 2355

Query: 1239 DEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEE 1298
             E +Q  L     +  +    L E+   L++Q                L   + EKL   
Sbjct: 2356 IEKLQQELANIGQKTSMNAHSLSEEADSLKHQ----------------LDVVIAEKL--- 2396

Query: 1299 KAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNT--------VLTREKMRKENIINDL 1350
                   LE+Q +  NEEM  ++  L   ++TNF           L RE+   E I +  
Sbjct: 2397 ------ALEQQVETANEEMTFMKNVL---KETNFKMNQLTQELFSLKRERESVEKIQSIP 2447

Query: 1351 SDKLKSTMQQQERDKDLIE-SLSEDRARLLEEK---KKLEE 1387
             + +   +    +DK  +E  L+ED  + LE +   K  EE
Sbjct: 2448 ENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2488



 Score = 85.5 bits (210), Expect = 4e-16
 Identities = 164/780 (21%), Positives = 342/780 (43%), Gaps = 165/780 (21%)

Query: 837  LKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLK 896
            ++C A ++R+ ++K   +LEI ++E+  +  + L+ E   +L  L ++ +  E +++K++
Sbjct: 2008 VQCQAEKVRDDLQKQVKALEIDVEEQVSR-FIELEQEKNTELMDLRQQNQALEKQLEKMR 2066

Query: 897  GEL----VCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEME---NIMHSQNCEIK 949
              L    +  E        E   ++ + + V   Q   + +  E+E   N +  +  +  
Sbjct: 2067 KFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCS 2126

Query: 950  ELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHL------KELED---------- 993
            EL  S+E +  D++    E +E+++ L   ++ LEQ+ L      +++ED          
Sbjct: 2127 ELLLSKEQLQRDIQ----ERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK 2182

Query: 994  ---TLQVR------HIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEI-IQEKEK-- 1041
               +L+V+       I   EK +T+    LE+ ++E +    ++Q+ H ++ IQ+KE   
Sbjct: 2183 PELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT 2242

Query: 1042 QLQELKLKVSDLSDTRCKLEVELALKEAE---TDEIKILLEE--SRAQQKETLKSLLEQE 1096
            +LQEL+ +     D   KL   LA+KE++   T +  +L  +     Q+KE     L ++
Sbjct: 2243 RLQELEQENKLFKDDMEKL--GLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQ 2300

Query: 1097 TENLRTE--ISKLNQKIQDNNENYQVGLAELRTLMT---------IEKDQCISELISRHE 1145
               L+ +  I+  N+ I++ NE  +    ++  LM+          E+ + ++E+I + +
Sbjct: 2301 VTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQ 2360

Query: 1146 ------------------EESNILKAELNKV----------TSLHNQAFEIEKNLKEQII 1177
                              EE++ LK +L+ V              N+     KN+ ++  
Sbjct: 2361 QELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETN 2420

Query: 1178 ELQSKLDSELSALERQKD--EKITQ-QEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQK- 1233
               ++L  EL +L+R+++  EKI    E      I +L KD+ +L     +D  + ++  
Sbjct: 2421 FKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQ 2480

Query: 1234 --------------LNCE------------KDEAIQTALKEFK-------LEREVVEKEL 1260
                          +N E            KD  +    K+ K        E E+++K++
Sbjct: 2481 TYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKI 2540

Query: 1261 LEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKF------------------ 1302
            +   K +E ++A            ++LV+++Q +  +E AKF                  
Sbjct: 2541 VNLQKIVEEKVA------------AALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2588

Query: 1303 LEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQE 1362
            L QL E E   +     +R S +  Q    +T L  EK + E    ++ +K K  ++ Q+
Sbjct: 2589 LNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQK 2648

Query: 1363 RDKDLIESLSEDRARLLEEKKKLEE-EVSKLRSSSFVPSPYVATAPELYGACAPELPGES 1421
                L+E  +E + R  E+K+  ++ EV K  +  F  +       EL    A  +  ++
Sbjct: 2649 ----LLEG-NEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKA 2703

Query: 1422 DRSAVETADEGRVDSAM--ETSMMSVQENIHM----LSEEKQRIMLLERTLQLKEEENKR 1475
            + ++ +   E   +  +  ET+M S+Q+++      L+E K+++ +LE+  + + +E+K+
Sbjct: 2704 ELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKK 2763



 Score = 84.3 bits (207), Expect = 8e-16
 Identities = 94/429 (21%), Positives = 203/429 (47%), Gaps = 58/429 (13%)

Query: 977  RAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEII 1036
            +A ++ L+++  + L   +Q  H Q     M   +++L    K  Q+     QE     I
Sbjct: 3076 QAAMECLQKADRRSLLSEIQALHAQ-----MNGRKITL----KREQESEKPSQELLEYNI 3126

Query: 1037 QEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQE 1096
            Q+K+ Q+ E+++++S + D   +L+ +L+ ++    E+K  L    AQ K  L++ L+ +
Sbjct: 3127 QQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSEL----AQTKLELETTLKAQ 3182

Query: 1097 TENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELN 1156
             ++L+ E+     +++D  +   +                +++ ++  +++S  L+  L 
Sbjct: 3183 HKHLK-ELEAFRLEVKDKTDEVHL----------------LNDTLASEQKKSRELQWALE 3225

Query: 1157 KVTSLHNQAFEIEKNLKEQI---IELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLE 1213
            K  +   ++ E +K   E +   +E Q + + +L+ L  Q+ + + + ++K E+  Q + 
Sbjct: 3226 KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIES--QRML 3283

Query: 1214 KDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAK 1273
             D Q    S+EQ R   +Q L     E+ +  ++E            L++ + L  Q+  
Sbjct: 3284 YDAQ---LSEEQGRNLELQVLL----ESEKVRIREM--------SSTLDRERELHAQLQS 3328

Query: 1274 SPAIDSTRG--DSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTN 1331
            S     +R    S  L+ ELQ++L+E+ ++ +E L E EK K + +Q  R  +  ++Q +
Sbjct: 3329 SDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQ-TRQQMEKDRQVH 3387

Query: 1332 FNTVLTREKMRKE--NIINDLSDKLKSTMQQQERDKDLIESLSEDRARL---LEEKKKLE 1386
              T+ T ++   E    +++L  K++   +Q E  +  +  L  +  RL   ++E +K E
Sbjct: 3388 RKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQE 3447

Query: 1387 EEVSKLRSS 1395
             E  + R S
Sbjct: 3448 LEREEKRES 3456



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 147/721 (20%), Positives = 310/721 (42%), Gaps = 79/721 (10%)

Query: 712  QTIHQVSLDLDSLAESPESD----FMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSS 767
            + +H   + + SL ESP SD     +  V+E  +EE  +  N IS  +  +++ +     
Sbjct: 2948 RAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLK--DLITKMQLQR 3005

Query: 768  VINAIDSRRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQ 827
                 DS +         E F D     + L   +V  ++    +   + +L    T   
Sbjct: 3006 EAEVYDSSQSH-------ESFSDWRG-ELLLALQQVFLEERSVLLAAFRTELTALGT--- 3054

Query: 828  KEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDG---LIKE 884
                D    L C    I+    + + ++E  L++  ++ LLS       +++G    +K 
Sbjct: 3055 ---TDAVGLLNCLEQRIQEQGVEYQAAMEC-LQKADRRSLLSEIQALHAQMNGRKITLKR 3110

Query: 885  TEENEN--------KIKKLKGELVCLE-EVLQNKDNEFAL---VKHEKEAVICLQNEKDQ 932
             +E+E          I++ + +++ ++ E+   KD    L   +  EK  V  L++E  Q
Sbjct: 3111 EQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQ 3170

Query: 933  KLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELE 992
              LE+E  + +Q+  +KEL+  R  V +   ++H+ ND    L   + +S E     E E
Sbjct: 3171 TKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLND---TLASEQKKSRELQWALEKE 3227

Query: 993  DTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSD 1052
                 R  +  ++ + D + SLE  K+ N Q +N + E   +++ E +++++        
Sbjct: 3228 KAKLGRSEERDKEELEDLKFSLESQKQRNLQ-LNLLLEQQKQLLNESQQKIE-------- 3278

Query: 1053 LSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQ 1112
                R   + +L+ ++    E+++LLE  + + +E + S L++E E L  ++   +   Q
Sbjct: 3279 --SQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE-MSSTLDRERE-LHAQLQSSDGTGQ 3334

Query: 1113 DNNENYQVGLAELRTLMTIEKDQCISELISRHEE---ESNILKAELNKVTSLHNQAFEIE 1169
                     L +       EK   I EL++  E+   +S   + ++ K   +H +  + E
Sbjct: 3335 SRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTE 3394

Query: 1170 KNL----KEQIIELQSKLDSELSALE--RQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQ 1223
            +      ++++ ELQSK++     LE  RQ+  K+  + ++ + I+Q  +K   +    +
Sbjct: 3395 QEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKR 3454

Query: 1224 EQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGD 1283
            E  R  L Q LN    E    +L   +    V+++++  + K  E+  AK   ++     
Sbjct: 3455 E-SRRILYQNLN----EPTTWSLTSDRTRNWVLQQKIEGETK--ESNYAKLIEMNGGGTG 3507

Query: 1284 SSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTV------LT 1337
             +  +  +++KLQ   +K   Q+  Q+  +  + +          Q N + +      LT
Sbjct: 3508 CNHELEMIRQKLQCVASKL--QVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLT 3565

Query: 1338 REKMRKENIINDLSDKLKSTMQQQERDKDL---IESLSEDRARLLEEKKKLEEEVSKLRS 1394
             ++  + ++++  +     T +   ++ +L   I  L+E++  L     KLEE++   R 
Sbjct: 3566 GQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQ 3625

Query: 1395 S 1395
            +
Sbjct: 3626 T 3626



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 175/779 (22%), Positives = 317/779 (40%), Gaps = 160/779 (20%)

Query: 825  FVQKEQCDFSNSLKC-------TAVEIRNIIEKV-KCSLEITLKEKH----QKELLSLKN 872
            F   E+  F N L+        T  E+ +  EK  K   E+ +KE +    QK+L  +++
Sbjct: 2679 FHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRD 2738

Query: 873  ---EYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNE 929
               E + KL  L KE E    + KK      C+ E L  K ++    + +    I   N+
Sbjct: 2739 HLAEAKEKLSILEKEDETEVQESKK-----ACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793

Query: 930  KDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLK 989
              Q L++   I  +   E    ++  EI+ +  +K+     EK+Q L          H  
Sbjct: 2794 TPQILVKNAGIQINLQSECSS-EEVTEIISQFTEKI-----EKMQEL----------HAA 2837

Query: 990  ELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQ-------ESHAEIIQEKEKQ 1042
            E+ D ++ RHI E E +  +H V+++ LK+E   +   IQ        S  E+      Q
Sbjct: 2838 EILD-MESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQ 2896

Query: 1043 LQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKET--------LKSLLE 1094
             +E+       SD+       + L  ++  +I     E R ++ E+        +K LL 
Sbjct: 2897 TREI-----CSSDSGSDWGQGIYLTHSQGFDI---ASEGRGEESESATDSFPKKIKGLL- 2947

Query: 1095 QETENLRTEISKLNQKIQDNNENYQV-------------------GLAELRTLMTIEKDQ 1135
            +   N   ++  L +    + E++ +                    L +L T M ++++ 
Sbjct: 2948 RAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREA 3007

Query: 1136 CISELISRH-------------------EEESNILKAELNKVTSLHNQAFE-----IEKN 1171
             + +    H                   EE S +L A   ++T+L           +E+ 
Sbjct: 3008 EVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQR 3067

Query: 1172 LKEQIIELQSKLD-----------SELSALERQKD-EKIT----QQEEK--YEAIIQNLE 1213
            ++EQ +E Q+ ++           SE+ AL  Q +  KIT    Q+ EK   E +  N++
Sbjct: 3068 IQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQ 3127

Query: 1214 KDRQKL------VSSQEQDREQLIQKLNCEK--DEAIQTALKEFKLEREVVEKELLEKVK 1265
            + + ++      +SS +    +L ++L+ EK     +++ L + KLE E   K   + +K
Sbjct: 3128 QKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLK 3187

Query: 1266 HLE-------NQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQ 1318
             LE       ++  +   ++ T         ELQ  L++EKAK    L   E+R  EE++
Sbjct: 3188 ELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAK----LGRSEERDKEELE 3243

Query: 1319 NVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARL 1378
            +++ SL +++Q N    L  E+ ++  ++N+   K++S     +        LSE++ R 
Sbjct: 3244 DLKFSLESQKQRNLQLNLLLEQQKQ--LLNESQQKIESQRMLYD------AQLSEEQGRN 3295

Query: 1379 LEEKKKLEEEVSKLRSSSFVPSPYVATAPELY-----GACAPELPGESDRSAVETADEGR 1433
            LE +  LE E  ++R  S           +L      G   P LP E     ++   E +
Sbjct: 3296 LELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK 3355

Query: 1434 ----VDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSV 1488
                V+   ET    +         EK R  +  +TLQ ++E N    Q+ M +  S V
Sbjct: 3356 HSRIVELLNETEKYKLDSLQTRQQMEKDR-QVHRKTLQTEQEANTE-GQKKMHELQSKV 3412



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 104/470 (22%), Positives = 199/470 (42%), Gaps = 55/470 (11%)

Query: 865  KELLSLKNEYEGKLDGLIKETEENENKIK-------KLKGELVCLEEVLQNKDNEFALVK 917
            +EL SLK E E      I+   EN   +        K + E+V  E+ L++ +N+     
Sbjct: 2428 QELFSLKRERESVEK--IQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKS 2485

Query: 918  HEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLR 977
             E+     + N  + +LL++E+ + +++ E+ +  +     ++D+++      E LQ   
Sbjct: 2486 FEENGKGSIIN-LETRLLQLESTVSAKDLELTQCYKQ----IKDMQEQGQFETEMLQKKI 2540

Query: 978  AELQSL-EQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEII 1036
              LQ + E+     L   +Q+  +QE+ K   D++    E ++ N Q +NQ++E      
Sbjct: 2541 VNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED----- 2595

Query: 1037 QEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETD--------------EIKILLEESR 1082
             E    +  L L++S+L     ++   L L++ + +              E++ LLE + 
Sbjct: 2596 -ELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNE 2654

Query: 1083 AQQKETLKSLLEQETENLR--TEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISEL 1140
             +Q+E  K    Q+ E L+  TE+   N++    NE     L  LR      K +  S  
Sbjct: 2655 KKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNE-----LEALRAESVATKAELASYK 2709

Query: 1141 ISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQ 1200
                + +  +L  E N +TSL     ++  +L E           +LS LE++ + ++  
Sbjct: 2710 EKAEKLQEELLVKETN-MTSLQKDLSQVRDHLAE--------AKEKLSILEKEDETEV-- 2758

Query: 1201 QEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKEL 1260
            QE K   + + L     K ++SQ  D    I   N      ++ A  +  L+ E   +E+
Sbjct: 2759 QESKKACMFEPLPIKLSKSIASQ-TDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEV 2817

Query: 1261 LEKVKHLENQIAKSPAIDSTR-GDSSSLVAELQEKLQEEKAKFLEQLEEQ 1309
             E +     +I K   + +    D  S      E L+ E    ++ L+E+
Sbjct: 2818 TEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEE 2867



 Score = 71.6 bits (174), Expect = 6e-12
 Identities = 129/628 (20%), Positives = 260/628 (41%), Gaps = 105/628 (16%)

Query: 843  EIRNIIEKVKCSLE-ITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVC 901
            E   I+ + K S E +T+ E+ ++E L L +      +  ++ T+ +EN   KL+ EL  
Sbjct: 1044 EESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSEND--KLQKEL-- 1099

Query: 902  LEEVLQNKDNEFALVKHEKEAVICL-------------QNEKDQKLLEM-ENIMHSQNCE 947
               VL+++ N+  L    +   + L             +NEKD+ L  + E ++ +Q  +
Sbjct: 1100 --NVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK 1157

Query: 948  IKELKQSREIVLEDLKKLHVENDEK-LQLLRAELQSLEQSHLKELEDTL----------- 995
            IKEL++  ++ L+ +K     ++ K L LL  +LQ            TL           
Sbjct: 1158 IKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPA 1217

Query: 996  ------------QVRHIQEFEKV-MTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQ 1042
                           +I E E   + D+R  +++ ++    ++N++ E + +++      
Sbjct: 1218 LKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLV----- 1272

Query: 1043 LQELKLKVSDLSDTRCKLEV-ELALKEAETDEIKIL-----LEESRAQQKETLKSL---- 1092
            LQ    K+        KLE  E  L + ET+ + I      LE+     K  L SL    
Sbjct: 1273 LQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLE 1332

Query: 1093 ---LEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCI-------SELIS 1142
               LE++ + L + IS L Q++++  +NY+  +  L+  +    +  +       S +I+
Sbjct: 1333 KTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVIT 1392

Query: 1143 RHEEESNILKAELNKVTSLHNQAFEIEKNLKEQ--IIEL-----QSKLDSELSALERQKD 1195
              + +  +      K        F  E  +KE+  I++L     Q +L+ E++ +     
Sbjct: 1393 ESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMS 1452

Query: 1196 EKITQQEEKYEAIIQNLEKDRQKLVSSQE-----QDREQLIQKLNCEKD----EAIQTAL 1246
                QQ E     +  +   ++   SS++     Q  +    ++   +D    +  +T  
Sbjct: 1453 IAFAQQTE-----LSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVD 1507

Query: 1247 KEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQL 1306
             +FK E + + KEL E  K    +I  S +      +S   V  + E++  +   F+ + 
Sbjct: 1508 VKFKEEFKPLSKELGEHGK----EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQ 1563

Query: 1307 EEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKD 1366
               ++     M   R  ++ E+Q         E MR+E ++    +  ++T   ++    
Sbjct: 1564 SIHDEISVSSMDASRQLMLNEEQL--------EDMRQE-LVRQYQEHQQATELLRQAHMR 1614

Query: 1367 LIESLSEDRARLLEEKKKLEEEVSKLRS 1394
             +E   ED+ +L EE K+L  ++++  S
Sbjct: 1615 QMERQREDQEQLQEEIKRLNRQLAQRSS 1642



 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 123/576 (21%), Positives = 247/576 (42%), Gaps = 121/576 (21%)

Query: 903  EEVLQNKDNEFALVKHEKEAVICLQNE---KDQKLLEMENIMHSQNCEIKELKQSREIVL 959
            E +L N D     +   K+ V+ +  E   KD+  +  ++I       +  +  SR+++L
Sbjct: 1527 EILLSNSDPHD--IPESKDCVLTISEEMFSKDKTFIVRQSI--HDEISVSSMDASRQLML 1582

Query: 960  EDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKK 1019
                     N+E+L+ +R EL    Q H ++  + L+  H+++ E+   D     EE+K+
Sbjct: 1583 ---------NEEQLEDMRQELVRQYQEH-QQATELLRQAHMRQMERQREDQEQLQEEIKR 1632

Query: 1020 ENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLS-DTRCKLEVELALKEAET---DEIK 1075
             N+Q+  +    +  ++ E+E+ L E    +  LS   R KL  EL     +T   +E +
Sbjct: 1633 LNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQ 1692

Query: 1076 ILLEESRAQQKETLKSLLEQETENLRTEI-SKLNQKIQD-NNENYQVGLAELRTLMTIE- 1132
              +EE   ++KE     L+++ E++  EI S     +Q  NN   ++ L  ++T   +E 
Sbjct: 1693 GEVEEQTFKEKE-----LDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEE 1747

Query: 1133 --------------KDQCISELISRHEEESNILKAELNKVTSLHNQAF------------ 1166
                          K Q  + LI R E E+++      + T + +++             
Sbjct: 1748 TIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRND 1807

Query: 1167 --------------------------EIEKNLKEQIIELQSKLDSELSAL--------ER 1192
                                      EI+   +E ++ + S+L + +  L         +
Sbjct: 1808 INMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQ 1867

Query: 1193 QKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLE 1252
             +  K+TQ E   E+  Q  +++  + +  QE+ RE+L ++    +  A++ +  E  ++
Sbjct: 1868 LEHAKVTQTELMRESFRQ--KQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVID 1925

Query: 1253 REVVEKELLEKVKHLENQI-AKSPAIDSTRGD---SSSLVAEL---QEKLQEEKAKFLEQ 1305
                EK L E+      QI  K+  ID    +   +S+ + EL   Q+++QEE+    E 
Sbjct: 1926 GYADEKTLFER------QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEER----EL 1975

Query: 1306 LEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKM----RKENIINDLSDKLKS----T 1357
            L  Q++    E   V   L+ E +      L +EK+    + E + +DL  ++K+     
Sbjct: 1976 LSRQKEAMKAEAGPVEQQLLQETEK-----LMKEKLEVQCQAEKVRDDLQKQVKALEIDV 2030

Query: 1358 MQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLR 1393
             +Q  R  +L +  + +   L ++ + LE+++ K+R
Sbjct: 2031 EEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR 2066



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 156/797 (19%), Positives = 331/797 (41%), Gaps = 115/797 (14%)

Query: 758  EMMVESLYSSVINAIDS-RRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHFSIQTIK 816
            E  V  L  +++ + D+ ++++D    G  +     SL VQL+  R         I  ++
Sbjct: 2150 EFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLE 2209

Query: 817  EDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEG 876
            E L  FR  ++ +  +               ++++   LEI             K E   
Sbjct: 2210 EQLEQFREELENKNEE---------------VQQLHMQLEIQ------------KKESTT 2242

Query: 877  KLDGLIKETEENENKIKKLKGELVCLEEVLQNKD-----NEFALVKHEKEAVICLQNEKD 931
            +L  L +E +  ++ ++KL G  +   + +  +D      +FA +  EKE  I   NE+ 
Sbjct: 2243 RLQELEQENKLFKDDMEKL-GLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV 2301

Query: 932  QKLLEM------ENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQ 985
             KL +         ++  +N  I++L+   E ++ D + +    +E+++ L   ++ L+Q
Sbjct: 2302 TKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQ 2361

Query: 986  SHLKELEDTLQVRHIQEFEKVMTDHRVSL---EELKKENQ-QIINQIQESHAEIIQEKEK 1041
                  + T    H    E     H++ +   E+L  E Q +  N+       +++E   
Sbjct: 2362 ELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNF 2421

Query: 1042 QLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENL- 1100
            ++ +L  ++  L   R  +E   ++ E   + + + ++     + E    L E   ++L 
Sbjct: 2422 KMNQLTQELFSLKRERESVEKIQSIPE---NSVNVAIDHLSKDKPELEVVLTEDALKSLE 2478

Query: 1101 -RTEISKLNQKIQDNNENYQVGLAELRTLMT---IEKDQCISELISRHEEESNILKAELN 1156
             +T      +  + +  N +  L +L + ++   +E  QC  ++  +  +E    + E+ 
Sbjct: 2479 NQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQI--KDMQEQGQFETEML 2536

Query: 1157 KVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDR 1216
            +   ++ Q    EK     + ++Q +   E +    Q ++ I+ + E+    IQNL + R
Sbjct: 2537 QKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKF-CQDNQTISSEPERTN--IQNLNQLR 2593

Query: 1217 QKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPA 1276
            +  + S        I +L  +  E + T+L   K + E+ EK +LEK K L         
Sbjct: 2594 EDELGSDISALTLRISELESQVVE-MHTSLILEKEQVEIAEKNVLEKEKKL--------- 2643

Query: 1277 IDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTS---LIAEQQTNFN 1333
                         ELQ+ L+  + K   Q E+++KR  ++++ ++T+     + +++ F 
Sbjct: 2644 ------------LELQKLLEGNEKK---QREKEKKRSPQDVEVLKTTTELFHSNEESGFF 2688

Query: 1334 TVLTREKMRKENI--------INDLSDKLKSTMQQQERD-KDLIESLSEDRARLLEEKKK 1384
              L  E +R E++          + ++KL+  +  +E +   L + LS+ R  L E K+K
Sbjct: 2689 NEL--EALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746

Query: 1385 L-------EEEVSKLRSS-SFVPSPY---VATAPELYGACAPELPGESDRSAVETADEGR 1433
            L       E EV + + +  F P P     + A +  G        ++ +  V+ A   +
Sbjct: 2747 LSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-Q 2805

Query: 1434 VDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHS 1493
            ++   E S   V E I   +E+      +E+  +L   E   +  R +S++  ++   H 
Sbjct: 2806 INLQSECSSEEVTEIISQFTEK------IEKMQELHAAEILDMESRHISET-ETLKREHY 2858

Query: 1494 EKIAIRDFQVGDLVLII 1510
              + +   + G L  +I
Sbjct: 2859 VAVQLLKEECGTLKAVI 2875



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 119/573 (20%), Positives = 242/573 (42%), Gaps = 79/573 (13%)

Query: 813  QTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEIT--LKEKHQKELLSL 870
            + +K+        ++K++  FS + K   V  + + E+  C L++   L++   K+ L  
Sbjct: 830  EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL-- 887

Query: 871  KNEYEGKLDGLIKE---------TEENENKI----KKLKGELVCLEEVLQNKDNEFA--- 914
              EY+ KL  L +E         T + ++ +    K    E + + EV++    E     
Sbjct: 888  --EYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKL 945

Query: 915  -LVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHV----EN 969
             + K EK  +    ++  ++L +    +   N E+K LKQ +E V    ++L +      
Sbjct: 946  EVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR 1005

Query: 970  DEKLQLLRAELQSLEQ------SHLKELEDTLQVRHIQEFEKVMTDHRVSLEEL-----K 1018
             E +Q    ++ SL        S   E   +   +   E  K+M + +VS E +      
Sbjct: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065

Query: 1019 KENQQIINQI----QESHAEIIQ--EKEKQLQELKLKVSDLSDTRCKLEVE-LALKEAET 1071
            K+ Q I++ +    +ES     Q  E +K  +EL +  S+ +D R ++E + + L    +
Sbjct: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125

Query: 1072 DEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTI 1131
              +  + E    ++ + L SL E+        I    +KI++  + +Q+ L  ++T  T 
Sbjct: 1126 THVDQVREYMENEKDKALCSLKEE-------LIFAQEEKIKELQKIHQLELQTMKTQETG 1178

Query: 1132 EKDQCISELISR-----HEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSE 1186
            ++ + +  LI +      EE S  L+   + +   +  A + E N +          D E
Sbjct: 1179 DEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAE----------DKE 1228

Query: 1187 LSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSS-QEQDREQLIQKLNCEKDEAIQTA 1245
             S     ++E    Q+ +YE  +Q+ +++   L++   E+  + L+ +    K    QT 
Sbjct: 1229 NSGDYISENEDPELQDYRYE--VQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTD 1286

Query: 1246 LKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLE- 1304
              + +   E + KE  E +  + +Q+     ID       S + +L++   EE+ + LE 
Sbjct: 1287 GMKLEFGEENLPKEETEFLS-IHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELES 1345

Query: 1305 -------QLEEQEKRKNEEMQNVRTSLIAEQQT 1330
                   QL+E E+    E+  ++  L A  ++
Sbjct: 1346 LISSLQQQLKETEQNYEAEIHCLQKRLQAVSES 1378



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 85/415 (20%), Positives = 159/415 (38%), Gaps = 83/415 (20%)

Query: 1129 MTIEKDQCISELISRHEE-------ESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQS 1181
            + I++ QC    I+  +        ES I++   +   + H Q F +E  L+ +I     
Sbjct: 55   LNIDQSQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVE--LESEISTTAD 112

Query: 1182 KLDSEL---SALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEK 1238
               SE+   S + R        +EE++       E+  Q   +  E    +L  K     
Sbjct: 113  DCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGK----- 167

Query: 1239 DEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEE 1298
                Q  ++E  L RE+ E  +    + L+       AI    G  + L A LQ+  +E+
Sbjct: 168  ----QHEIEE--LNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREK 221

Query: 1299 KAKFLEQLE--EQEKRKNEEMQNVRTSLIAEQQTNFNT----------VLTREKMRKE-- 1344
                 E LE  EQ ++   + Q ++ S      T+ +T          +LT ++  +E  
Sbjct: 222  DETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQD 281

Query: 1345 NIINDLSDKLKS-TMQ-----------QQERDKDLIESLSED-----------RARLLEE 1381
            +++ D   K +  TMQ           + E+DK +  S  E+             +++EE
Sbjct: 282  HLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEE 341

Query: 1382 KKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETS 1441
            +KK  E   KL +                   A +L GE     V+   E +    M+  
Sbjct: 342  EKKTLELKDKLTT-------------------ADKLLGELQEQIVQKNQEIK---NMKLE 379

Query: 1442 MMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEKI 1496
            + + ++     SEE +++M     LQ +  ++ +    ++ Q M   + R  E++
Sbjct: 380  LTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIV-QRMEQETQRKLEQL 433


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score =  119 bits (298), Expect = 2e-26
 Identities = 174/783 (22%), Positives = 348/783 (44%), Gaps = 115/783 (14%)

Query: 797  QLERCRVVAQDSHFS-----IQTIKEDLCHFRTFVQKEQC--DFSNSLKCTAVEIRNIIE 849
            QL+    +   +H S     +Q  ++ L H +   +++    D+    +   ++I  + E
Sbjct: 244  QLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQE 303

Query: 850  KVKCSLEITLKEKHQKELLSLKNEYEGK---LDGLIKETEENENKIKKLKGELVCLEEVL 906
            K+K    +   E+ +K   S K E + K   ++ L  +  E E K  +LK +L   +++L
Sbjct: 304  KIK----VYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLL 359

Query: 907  QNKDNEFALVKHE-KEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSR----EIVLED 961
                 +      E K   + L N K ++    E I       ++EL++      +   + 
Sbjct: 360  GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGT-VEELQKRNHKDSQFETDI 418

Query: 962  LKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEE-LKKE 1020
            ++++  E   KL+ LRAEL  +    + +++  L  +H+ + E++ T H+  +E  L+  
Sbjct: 419  VQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY 478

Query: 1021 NQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELAL----KEAETDEIKI 1076
            +   +N+ Q      I+     + EL +K+ D +  + KL+ EL L    K A   +++ 
Sbjct: 479  SNITVNEDQ------IKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLED 532

Query: 1077 LLEE---SRAQQKETLKSLLEQET------------ENLRTEI-------SKLNQKIQDN 1114
            L+EE   SR Q +   +++ EQE+            E+L+ EI        +L  K +  
Sbjct: 533  LVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAE 592

Query: 1115 NENYQVGLAELR-----------TLMTIEKDQCISELISRHEEESNILKAELNKVTSLHN 1163
              NY++ L  L                 E ++  ++L+  HEEE + LK +L     ++ 
Sbjct: 593  VTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINI 652

Query: 1164 QAFEIEKNL----KEQIIELQSKLDSELSALERQKDEKITQQEE------KYEAIIQNLE 1213
            +  +++ NL    K+QI  LQ+++  ++  ++ +KD  IT+Q +      K + + Q+L 
Sbjct: 653  E--KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV 710

Query: 1214 KDRQKLVSSQEQDREQLIQKLNCEKDE--AIQTALKEFKLEREVVEKELLEKVKHLENQI 1271
              + + ++ Q  + ++ I+ L  E+ E   ++  ++E +L+ E++EK++ EK   L+ + 
Sbjct: 711  NSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKF 770

Query: 1272 AKSPAIDSTRGDSSSLVAELQE----KLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAE 1327
            A+  A +S   D    + ++ +      QEE+  FL+ ++ + K   + +      ++ E
Sbjct: 771  AQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSK---DSVWEKEIEILIE 827

Query: 1328 QQTNFNTVLTREKMRKENI-INDLSDKLKSTMQQQERDKDL-IESLSEDRARLLEEKKKL 1385
            +          E ++++ I +N+  +K ++T    E++ ++  + L E+ A LL+ K  L
Sbjct: 828  E---------NEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL 878

Query: 1386 EEEVSKLRSSSFVPSPYVATAPELY--------GACAPELPGESDRSAVETADEGRVDSA 1437
            E+  SK +      S   A   EL+              +  E      ET + G V   
Sbjct: 879  ED--SKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEV--- 933

Query: 1438 METSMMSVQENIHMLSEEK----QRIMLLERTLQLKEEENKRLNQRLMS--QSMSSVSSR 1491
            +E     + E + +   EK    QR+  L   L+ K  E   LN+ + S  Q    VS R
Sbjct: 934  VEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLR 993

Query: 1492 HSE 1494
              E
Sbjct: 994  CRE 996



 Score = 97.8 bits (242), Expect = 7e-20
 Identities = 143/689 (20%), Positives = 308/689 (44%), Gaps = 95/689 (13%)

Query: 794  LNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKC 853
            +NV +    +  QD++   + +KE+L      + +E+C     L+       +++E++  
Sbjct: 491  MNVAINELNIKLQDTNSQKEKLKEEL----GLILEEKCALQRQLE-------DLVEELSF 539

Query: 854  SLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEF 913
            S     +E+ Q+   ++  E E KL+    E  ++ + ++ LK E+V   E    K+ E 
Sbjct: 540  S-----REQIQRARQTIA-EQESKLN----EAHKSLSTVEDLKAEIVSASE--SRKELE- 586

Query: 914  ALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLK-KLHVENDEK 972
              +KHE E      N K    +++E +   +N  +  + +S+E  LE L+ +L   ++E+
Sbjct: 587  --LKHEAEVT----NYK----IKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEE 636

Query: 973  LQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESH 1032
            L  L+ +L+   + ++++L+D L + + Q+ + +  +    +E ++ E   +I +  +  
Sbjct: 637  LSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI 696

Query: 1033 AEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSL 1092
             EI + K+ Q   +  K  +++         L + E +  EI+IL      +Q+E  K  
Sbjct: 697  LEISKLKDLQQSLVNSKSEEMT---------LQINELQK-EIEIL------RQEEKEKGT 740

Query: 1093 LEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQ--CISELISRHEEESNI 1150
            LEQE + L+ +   L +++++   + Q   A+L    +I KD+   + +++  H   S  
Sbjct: 741  LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVS-- 798

Query: 1151 LKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQ 1210
               +  ++  L +   + + ++ E+ IE+  + + +L     Q +E+I +Q   +    +
Sbjct: 799  ---QEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEK 855

Query: 1211 NLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKEL-LEKVKHLEN 1269
            N E + Q+L     Q+    + K+  + +++      E+K + + + +EL L+++     
Sbjct: 856  NFEVNYQEL-----QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTV 910

Query: 1270 QIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQ 1329
            ++ KS   D    +  + VAE            LE  E  EK   E M+ +         
Sbjct: 911  KM-KSSVFD----EDKTFVAET-----------LEMGEVVEKDTTELMEKLE-------- 946

Query: 1330 TNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEV 1389
                 V  REK+     ++DLS++LK    +     + ++SL +++ ++    ++LE  +
Sbjct: 947  -----VTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIII 1001

Query: 1390 SKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENI 1449
            +  R+ + V S     +  L G       G     +      G     M    +S  EN+
Sbjct: 1002 NHNRAEN-VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSF-ENM 1059

Query: 1450 HMLSEEKQRIMLLERTLQLKEEENKRLNQ 1478
             +  E KQ  ++L+    + +E + R  Q
Sbjct: 1060 TVGEESKQEQLILDHLPSVTKESSLRATQ 1088



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 149/616 (24%), Positives = 274/616 (44%), Gaps = 103/616 (16%)

Query: 849  EKVKCSLEITLK---EKHQKELLSLK-NEYEGKLDGLIKET-------EENENKIKKLKG 897
            E +KC  E+  +   E   +E L+++ ++ EG +DG   E        +E  + I +L+ 
Sbjct: 1891 ESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQ 1950

Query: 898  ELVC-------LEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIK- 949
            EL+C       LE   Q    E  L+  +KEA+       +Q+LL+    +  +  E++ 
Sbjct: 1951 ELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQC 2010

Query: 950  ELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTD 1009
            + ++ R+ + + +K L ++ +E++    +    LEQ    EL D  Q    Q  EK +  
Sbjct: 2011 QAEKVRDDLQKQVKALEIDVEEQV----SRFIELEQEKNTELMDLRQQN--QALEKQLEK 2064

Query: 1010 HRVSLEE--LKKENQQIINQIQESHAEIIQEKEKQLQELKL--KVSDLSDTRCKLEVELA 1065
             R  L+E  + +E+++ + Q         QE +K  Q+LK+  +   +S+ + +   +LA
Sbjct: 2065 MRKFLDEQAIDREHERDVFQ---------QEIQKLEQQLKVVPRFQPISEHQTREVEQLA 2115

Query: 1066 --LKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLA 1123
              LKE +TD+   LL      Q++  +    +E E L   + +L Q +   +  +  G  
Sbjct: 2116 NHLKE-KTDKCSELLLSKEQLQRDIQER--NEEIEKLEFRVRELEQALLVEDRKH-FGAV 2171

Query: 1124 ELRTLMTIEKD-QCISELISRHEEESNILKAEL-----------NKVTSLHNQAFEIEK- 1170
            E +  +++E   Q   + I R E+E   L+ +L            +V  LH Q  EI+K 
Sbjct: 2172 EAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQ-LEIQKK 2230

Query: 1171 --NLKEQIIELQSKL---DSELSALERQKDEKITQQEE-----KYEAIIQNLEKD----R 1216
                + Q +E ++KL   D E   L  ++ + ++ Q++     K+  IIQ  E +     
Sbjct: 2231 ESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLN 2290

Query: 1217 QKLVSSQEQDREQLIQKLNCEKDEAI---QTALKEFKLEREVVEKELLEKVKHLENQIAK 1273
            +++   Q+Q +     K+  EK+E I   +T ++    ++E V++   E+++ L   I K
Sbjct: 2291 EQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEK 2350

Query: 1274 SPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQ----------LEEQEKRKNEEMQNVRTS 1323
                 +  G  +S+ A     L EE      Q          LE+Q +  NEEM  ++  
Sbjct: 2351 LQQELANIGQKTSMNA---HSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNV 2407

Query: 1324 LIAEQQTNFNT--------VLTREKMRKENIINDLSDKLKSTMQQQERDKDLIE-SLSED 1374
            L   ++TNF           L RE+   E I +   + +   +    +DK  +E  L+ED
Sbjct: 2408 L---KETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2464

Query: 1375 RARLLEEK---KKLEE 1387
              + LE +   K  EE
Sbjct: 2465 ALKSLENQTYFKSFEE 2480



 Score = 84.3 bits (207), Expect = 8e-16
 Identities = 94/429 (21%), Positives = 203/429 (47%), Gaps = 58/429 (13%)

Query: 977  RAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEII 1036
            +A ++ L+++  + L   +Q  H Q     M   +++L    K  Q+     QE     I
Sbjct: 3068 QAAMECLQKADRRSLLSEIQALHAQ-----MNGRKITL----KREQESEKPSQELLEYNI 3118

Query: 1037 QEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQE 1096
            Q+K+ Q+ E+++++S + D   +L+ +L+ ++    E+K  L    AQ K  L++ L+ +
Sbjct: 3119 QQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSEL----AQTKLELETTLKAQ 3174

Query: 1097 TENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELN 1156
             ++L+ E+     +++D  +   +                +++ ++  +++S  L+  L 
Sbjct: 3175 HKHLK-ELEAFRLEVKDKTDEVHL----------------LNDTLASEQKKSRELQWALE 3217

Query: 1157 KVTSLHNQAFEIEKNLKEQI---IELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLE 1213
            K  +   ++ E +K   E +   +E Q + + +L+ L  Q+ + + + ++K E+  Q + 
Sbjct: 3218 KEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIES--QRML 3275

Query: 1214 KDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAK 1273
             D Q    S+EQ R   +Q L     E+ +  ++E            L++ + L  Q+  
Sbjct: 3276 YDAQ---LSEEQGRNLELQVLL----ESEKVRIREM--------SSTLDRERELHAQLQS 3320

Query: 1274 SPAIDSTRG--DSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTN 1331
            S     +R    S  L+ ELQ++L+E+ ++ +E L E EK K + +Q  R  +  ++Q +
Sbjct: 3321 SDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQ-TRQQMEKDRQVH 3379

Query: 1332 FNTVLTREKMRKE--NIINDLSDKLKSTMQQQERDKDLIESLSEDRARL---LEEKKKLE 1386
              T+ T ++   E    +++L  K++   +Q E  +  +  L  +  RL   ++E +K E
Sbjct: 3380 RKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQE 3439

Query: 1387 EEVSKLRSS 1395
             E  + R S
Sbjct: 3440 LEREEKRES 3448



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 157/775 (20%), Positives = 336/775 (43%), Gaps = 163/775 (21%)

Query: 837  LKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLK 896
            ++C A ++R+ ++K   +LEI ++E+  +  + L+ E   +L  L ++ +  E +++K++
Sbjct: 2008 VQCQAEKVRDDLQKQVKALEIDVEEQVSR-FIELEQEKNTELMDLRQQNQALEKQLEKMR 2066

Query: 897  GELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLL-EMENIMHSQNCEIKELKQSR 955
                 L+E   ++++E  + + E + +     E+  K++   + I   Q  E+++L    
Sbjct: 2067 K---FLDEQAIDREHERDVFQQEIQKL-----EQQLKVVPRFQPISEHQTREVEQLANHL 2118

Query: 956  EIVLEDLKKLHVENDE---KLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRV 1012
            +   +   +L +  ++    +Q    E++ LE   ++ELE  L V   + F  V     +
Sbjct: 2119 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLE-FRVRELEQALLVEDRKHFGAVEAKPEL 2177

Query: 1013 SLE-ELKKENQQI---------INQIQESHAEIIQEKEKQLQELKLKV---SDLSDTRC- 1058
            SLE +L+ E   I         + +  E   E ++ K +++Q+L +++      S TR  
Sbjct: 2178 SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQ 2237

Query: 1059 KLEVELALKEAETDEIKILLEESRAQQKETLKSLL----------EQETENLRTEISKLN 1108
            +LE E  L + + +++ + ++ES A   +    L           E E + L  +++KL 
Sbjct: 2238 ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQ 2297

Query: 1109 QK---------IQDNNENYQVGLAELRTLMT---------IEKDQCISELISRHE----- 1145
            Q+         I++ NE  +    ++  LM+          E+ + ++E+I + +     
Sbjct: 2298 QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELAN 2357

Query: 1146 -------------EESNILKAELNKV----------TSLHNQAFEIEKNLKEQIIELQSK 1182
                         EE++ LK +L+ V              N+     KN+ ++     ++
Sbjct: 2358 IGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQ 2417

Query: 1183 LDSELSALERQKD--EKITQ-QEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQK------ 1233
            L  EL +L+R+++  EKI    E      I +L KD+ +L     +D  + ++       
Sbjct: 2418 LTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKS 2477

Query: 1234 ---------LNCE------------KDEAIQTALKEFK-------LEREVVEKELLEKVK 1265
                     +N E            KD  +    K+ K        E E+++K+++   K
Sbjct: 2478 FEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQK 2537

Query: 1266 HLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKF------------------LEQLE 1307
             +E ++A            ++LV+++Q +  +E AKF                  L QL 
Sbjct: 2538 IVEEKVA------------AALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLR 2585

Query: 1308 EQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDL 1367
            E E   +     +R S +  Q    +T L  EK + E    ++ +K K  ++ Q+    L
Sbjct: 2586 EDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQK----L 2641

Query: 1368 IESLSEDRARLLEEKKKLEE-EVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAV 1426
            +E  +E + R  E+K+  ++ EV K  +  F  +       EL    A  +  +++ ++ 
Sbjct: 2642 LEG-NEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASY 2700

Query: 1427 ETADEGRVDSAM--ETSMMSVQENIHM----LSEEKQRIMLLERTLQLKEEENKR 1475
            +   E   +  +  ET+M S+Q+++      L+E K+++ +LE+  + + +E+K+
Sbjct: 2701 KEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKK 2755



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 147/721 (20%), Positives = 310/721 (42%), Gaps = 79/721 (10%)

Query: 712  QTIHQVSLDLDSLAESPESD----FMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSS 767
            + +H   + + SL ESP SD     +  V+E  +EE  +  N IS  +  +++ +     
Sbjct: 2940 RAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLK--DLITKMQLQR 2997

Query: 768  VINAIDSRRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQ 827
                 DS +         E F D     + L   +V  ++    +   + +L    T   
Sbjct: 2998 EAEVYDSSQSH-------ESFSDWRG-ELLLALQQVFLEERSVLLAAFRTELTALGT--- 3046

Query: 828  KEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDG---LIKE 884
                D    L C    I+    + + ++E  L++  ++ LLS       +++G    +K 
Sbjct: 3047 ---TDAVGLLNCLEQRIQEQGVEYQAAMEC-LQKADRRSLLSEIQALHAQMNGRKITLKR 3102

Query: 885  TEENEN--------KIKKLKGELVCLE-EVLQNKDNEFAL---VKHEKEAVICLQNEKDQ 932
             +E+E          I++ + +++ ++ E+   KD    L   +  EK  V  L++E  Q
Sbjct: 3103 EQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQ 3162

Query: 933  KLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELE 992
              LE+E  + +Q+  +KEL+  R  V +   ++H+ ND    L   + +S E     E E
Sbjct: 3163 TKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLND---TLASEQKKSRELQWALEKE 3219

Query: 993  DTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSD 1052
                 R  +  ++ + D + SLE  K+ N Q +N + E   +++ E +++++        
Sbjct: 3220 KAKLGRSEERDKEELEDLKFSLESQKQRNLQ-LNLLLEQQKQLLNESQQKIE-------- 3270

Query: 1053 LSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQ 1112
                R   + +L+ ++    E+++LLE  + + +E + S L++E E L  ++   +   Q
Sbjct: 3271 --SQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE-MSSTLDRERE-LHAQLQSSDGTGQ 3326

Query: 1113 DNNENYQVGLAELRTLMTIEKDQCISELISRHEE---ESNILKAELNKVTSLHNQAFEIE 1169
                     L +       EK   I EL++  E+   +S   + ++ K   +H +  + E
Sbjct: 3327 SRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTE 3386

Query: 1170 KNL----KEQIIELQSKLDSELSALE--RQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQ 1223
            +      ++++ ELQSK++     LE  RQ+  K+  + ++ + I+Q  +K   +    +
Sbjct: 3387 QEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKR 3446

Query: 1224 EQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGD 1283
            E  R  L Q LN    E    +L   +    V+++++  + K  E+  AK   ++     
Sbjct: 3447 E-SRRILYQNLN----EPTTWSLTSDRTRNWVLQQKIEGETK--ESNYAKLIEMNGGGTG 3499

Query: 1284 SSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTV------LT 1337
             +  +  +++KLQ   +K   Q+  Q+  +  + +          Q N + +      LT
Sbjct: 3500 CNHELEMIRQKLQCVASKL--QVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLT 3557

Query: 1338 REKMRKENIINDLSDKLKSTMQQQERDKDL---IESLSEDRARLLEEKKKLEEEVSKLRS 1394
             ++  + ++++  +     T +   ++ +L   I  L+E++  L     KLEE++   R 
Sbjct: 3558 GQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQ 3617

Query: 1395 S 1395
            +
Sbjct: 3618 T 3618



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 175/779 (22%), Positives = 317/779 (40%), Gaps = 160/779 (20%)

Query: 825  FVQKEQCDFSNSLKC-------TAVEIRNIIEKV-KCSLEITLKEKH----QKELLSLKN 872
            F   E+  F N L+        T  E+ +  EK  K   E+ +KE +    QK+L  +++
Sbjct: 2671 FHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRD 2730

Query: 873  ---EYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNE 929
               E + KL  L KE E    + KK      C+ E L  K ++    + +    I   N+
Sbjct: 2731 HLAEAKEKLSILEKEDETEVQESKK-----ACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2785

Query: 930  KDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLK 989
              Q L++   I  +   E    ++  EI+ +  +K+     EK+Q L          H  
Sbjct: 2786 TPQILVKNAGIQINLQSECSS-EEVTEIISQFTEKI-----EKMQEL----------HAA 2829

Query: 990  ELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQ-------ESHAEIIQEKEKQ 1042
            E+ D ++ RHI E E +  +H V+++ LK+E   +   IQ        S  E+      Q
Sbjct: 2830 EILD-MESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQ 2888

Query: 1043 LQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKET--------LKSLLE 1094
             +E+       SD+       + L  ++  +I     E R ++ E+        +K LL 
Sbjct: 2889 TREI-----CSSDSGSDWGQGIYLTHSQGFDI---ASEGRGEESESATDSFPKKIKGLL- 2939

Query: 1095 QETENLRTEISKLNQKIQDNNENYQV-------------------GLAELRTLMTIEKDQ 1135
            +   N   ++  L +    + E++ +                    L +L T M ++++ 
Sbjct: 2940 RAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREA 2999

Query: 1136 CISELISRH-------------------EEESNILKAELNKVTSLHNQAFE-----IEKN 1171
             + +    H                   EE S +L A   ++T+L           +E+ 
Sbjct: 3000 EVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQR 3059

Query: 1172 LKEQIIELQSKLD-----------SELSALERQKD-EKIT----QQEEK--YEAIIQNLE 1213
            ++EQ +E Q+ ++           SE+ AL  Q +  KIT    Q+ EK   E +  N++
Sbjct: 3060 IQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQ 3119

Query: 1214 KDRQKL------VSSQEQDREQLIQKLNCEK--DEAIQTALKEFKLEREVVEKELLEKVK 1265
            + + ++      +SS +    +L ++L+ EK     +++ L + KLE E   K   + +K
Sbjct: 3120 QKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLK 3179

Query: 1266 HLE-------NQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQ 1318
             LE       ++  +   ++ T         ELQ  L++EKAK    L   E+R  EE++
Sbjct: 3180 ELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAK----LGRSEERDKEELE 3235

Query: 1319 NVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARL 1378
            +++ SL +++Q N    L  E+ ++  ++N+   K++S     +        LSE++ R 
Sbjct: 3236 DLKFSLESQKQRNLQLNLLLEQQKQ--LLNESQQKIESQRMLYD------AQLSEEQGRN 3287

Query: 1379 LEEKKKLEEEVSKLRSSSFVPSPYVATAPELY-----GACAPELPGESDRSAVETADEGR 1433
            LE +  LE E  ++R  S           +L      G   P LP E     ++   E +
Sbjct: 3288 LELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK 3347

Query: 1434 ----VDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSV 1488
                V+   ET    +         EK R  +  +TLQ ++E N    Q+ M +  S V
Sbjct: 3348 HSRIVELLNETEKYKLDSLQTRQQMEKDR-QVHRKTLQTEQEANTE-GQKKMHELQSKV 3404



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 104/470 (22%), Positives = 199/470 (42%), Gaps = 55/470 (11%)

Query: 865  KELLSLKNEYEGKLDGLIKETEENENKIK-------KLKGELVCLEEVLQNKDNEFALVK 917
            +EL SLK E E      I+   EN   +        K + E+V  E+ L++ +N+     
Sbjct: 2420 QELFSLKRERESVEK--IQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKS 2477

Query: 918  HEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLR 977
             E+     + N  + +LL++E+ + +++ E+ +  +     ++D+++      E LQ   
Sbjct: 2478 FEENGKGSIIN-LETRLLQLESTVSAKDLELTQCYKQ----IKDMQEQGQFETEMLQKKI 2532

Query: 978  AELQSL-EQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEII 1036
              LQ + E+     L   +Q+  +QE+ K   D++    E ++ N Q +NQ++E      
Sbjct: 2533 VNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED----- 2587

Query: 1037 QEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETD--------------EIKILLEESR 1082
             E    +  L L++S+L     ++   L L++ + +              E++ LLE + 
Sbjct: 2588 -ELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNE 2646

Query: 1083 AQQKETLKSLLEQETENLR--TEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISEL 1140
             +Q+E  K    Q+ E L+  TE+   N++    NE     L  LR      K +  S  
Sbjct: 2647 KKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNE-----LEALRAESVATKAELASYK 2701

Query: 1141 ISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQ 1200
                + +  +L  E N +TSL     ++  +L E           +LS LE++ + ++  
Sbjct: 2702 EKAEKLQEELLVKETN-MTSLQKDLSQVRDHLAE--------AKEKLSILEKEDETEV-- 2750

Query: 1201 QEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKEL 1260
            QE K   + + L     K ++SQ  D    I   N      ++ A  +  L+ E   +E+
Sbjct: 2751 QESKKACMFEPLPIKLSKSIASQ-TDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEV 2809

Query: 1261 LEKVKHLENQIAKSPAIDSTR-GDSSSLVAELQEKLQEEKAKFLEQLEEQ 1309
             E +     +I K   + +    D  S      E L+ E    ++ L+E+
Sbjct: 2810 TEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEE 2859



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 143/695 (20%), Positives = 285/695 (41%), Gaps = 136/695 (19%)

Query: 903  EEVLQNKDNEFALVKHEKEAVICLQNE---KDQKLLEMENIMHSQNCEIKELKQSREIVL 959
            E +L N D     +   K+ V+ +  E   KD+  +  ++I       +  +  SR+++L
Sbjct: 1527 EILLSNSDPHD--IPESKDCVLTISEEMFSKDKTFIVRQSI--HDEISVSSMDASRQLML 1582

Query: 960  EDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKK 1019
                     N+E+L+ +R EL    Q H ++  + L+  H+++ E+   D     EE+K+
Sbjct: 1583 ---------NEEQLEDMRQELVRQYQEH-QQATELLRQAHMRQMERQREDQEQLQEEIKR 1632

Query: 1020 ENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDT-RCKLEVELALKEAET---DEIK 1075
             N+Q+  +    +  ++ E+E+ L E    +  LS   R KL  EL     +T   +E +
Sbjct: 1633 LNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQ 1692

Query: 1076 ILLEESRAQQKETLKSLLEQETENLRTEI-SKLNQKIQD-NNENYQVGLAELRTLMTIE- 1132
              +EE   ++KE     L+++ E++  EI S     +Q  NN   ++ L  ++T   +E 
Sbjct: 1693 GEVEEQTFKEKE-----LDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEE 1747

Query: 1133 --------------KDQCISELISRHEEESNILKAELNKVTSLHNQAF------------ 1166
                          K Q  + LI R E E+++      + T + +++             
Sbjct: 1748 TIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRND 1807

Query: 1167 --------------------------EIEKNLKEQIIELQSKLDSELSALERQKDE---- 1196
                                      EI+   +E ++ + S+L + +  L     E    
Sbjct: 1808 INMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQ 1867

Query: 1197 ----KITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLE 1252
                K+TQ E   E+  Q  E      +  QE+ RE+L ++    +  A++ +  E  ++
Sbjct: 1868 LEHAKVTQTELMRESFRQKQEATES--LKCQEELRERLHEESRAREQLAVELSKAEGVID 1925

Query: 1253 REVVEKELLEKVKHLENQIA-KSPAIDSTRGD---SSSLVAEL---QEKLQEEKAKFLEQ 1305
                EK L E+      QI  K+  ID    +   +S+ + EL   Q+++QEE+    E 
Sbjct: 1926 GYADEKTLFER------QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEER----EL 1975

Query: 1306 LEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENI-INDLSDKLKSTMQQQERD 1364
            L  Q++    E   V   L+ E           EK+ KE + +   ++K++  +Q+Q + 
Sbjct: 1976 LSRQKEAMKAEAGPVEQQLLQET----------EKLMKEKLEVQCQAEKVRDDLQKQVKA 2025

Query: 1365 KDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESD-- 1422
             ++   + E  +R +E +++   E+  LR  +      +    +     A +   E D  
Sbjct: 2026 LEI--DVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVF 2083

Query: 1423 RSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMS 1482
            +  ++  ++           + V      +SE + R  + +    LKE+ +K     L  
Sbjct: 2084 QQEIQKLEQ----------QLKVVPRFQPISEHQTR-EVEQLANHLKEKTDKCSELLLSK 2132

Query: 1483 QSMSSVSSRHSEKIAIRDFQVGDL--VLIILDERH 1515
            + +       +E+I   +F+V +L   L++ D +H
Sbjct: 2133 EQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKH 2167



 Score = 71.6 bits (174), Expect = 6e-12
 Identities = 129/628 (20%), Positives = 260/628 (41%), Gaps = 105/628 (16%)

Query: 843  EIRNIIEKVKCSLE-ITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVC 901
            E   I+ + K S E +T+ E+ ++E L L +      +  ++ T+ +EN   KL+ EL  
Sbjct: 1044 EESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSEND--KLQKEL-- 1099

Query: 902  LEEVLQNKDNEFALVKHEKEAVICL-------------QNEKDQKLLEM-ENIMHSQNCE 947
               VL+++ N+  L    +   + L             +NEKD+ L  + E ++ +Q  +
Sbjct: 1100 --NVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK 1157

Query: 948  IKELKQSREIVLEDLKKLHVENDEK-LQLLRAELQSLEQSHLKELEDTL----------- 995
            IKEL++  ++ L+ +K     ++ K L LL  +LQ            TL           
Sbjct: 1158 IKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPA 1217

Query: 996  ------------QVRHIQEFEKV-MTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQ 1042
                           +I E E   + D+R  +++ ++    ++N++ E + +++      
Sbjct: 1218 LKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLV----- 1272

Query: 1043 LQELKLKVSDLSDTRCKLEV-ELALKEAETDEIKIL-----LEESRAQQKETLKSL---- 1092
            LQ    K+        KLE  E  L + ET+ + I      LE+     K  L SL    
Sbjct: 1273 LQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLE 1332

Query: 1093 ---LEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCI-------SELIS 1142
               LE++ + L + IS L Q++++  +NY+  +  L+  +    +  +       S +I+
Sbjct: 1333 KTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVIT 1392

Query: 1143 RHEEESNILKAELNKVTSLHNQAFEIEKNLKEQ--IIEL-----QSKLDSELSALERQKD 1195
              + +  +      K        F  E  +KE+  I++L     Q +L+ E++ +     
Sbjct: 1393 ESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMS 1452

Query: 1196 EKITQQEEKYEAIIQNLEKDRQKLVSSQE-----QDREQLIQKLNCEKD----EAIQTAL 1246
                QQ E     +  +   ++   SS++     Q  +    ++   +D    +  +T  
Sbjct: 1453 IAFAQQTE-----LSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVD 1507

Query: 1247 KEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQL 1306
             +FK E + + KEL E  K    +I  S +      +S   V  + E++  +   F+ + 
Sbjct: 1508 VKFKEEFKPLSKELGEHGK----EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQ 1563

Query: 1307 EEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKD 1366
               ++     M   R  ++ E+Q         E MR+E ++    +  ++T   ++    
Sbjct: 1564 SIHDEISVSSMDASRQLMLNEEQL--------EDMRQE-LVRQYQEHQQATELLRQAHMR 1614

Query: 1367 LIESLSEDRARLLEEKKKLEEEVSKLRS 1394
             +E   ED+ +L EE K+L  ++++  S
Sbjct: 1615 QMERQREDQEQLQEEIKRLNRQLAQRSS 1642



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 119/573 (20%), Positives = 242/573 (42%), Gaps = 79/573 (13%)

Query: 813  QTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEIT--LKEKHQKELLSL 870
            + +K+        ++K++  FS + K   V  + + E+  C L++   L++   K+ L  
Sbjct: 830  EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL-- 887

Query: 871  KNEYEGKLDGLIKE---------TEENENKI----KKLKGELVCLEEVLQNKDNEFA--- 914
              EY+ KL  L +E         T + ++ +    K    E + + EV++    E     
Sbjct: 888  --EYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKL 945

Query: 915  -LVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHV----EN 969
             + K EK  +    ++  ++L +    +   N E+K LKQ +E V    ++L +      
Sbjct: 946  EVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR 1005

Query: 970  DEKLQLLRAELQSLEQ------SHLKELEDTLQVRHIQEFEKVMTDHRVSLEEL-----K 1018
             E +Q    ++ SL        S   E   +   +   E  K+M + +VS E +      
Sbjct: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065

Query: 1019 KENQQIINQI----QESHAEIIQ--EKEKQLQELKLKVSDLSDTRCKLEVE-LALKEAET 1071
            K+ Q I++ +    +ES     Q  E +K  +EL +  S+ +D R ++E + + L    +
Sbjct: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125

Query: 1072 DEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTI 1131
              +  + E    ++ + L SL E+        I    +KI++  + +Q+ L  ++T  T 
Sbjct: 1126 THVDQVREYMENEKDKALCSLKEE-------LIFAQEEKIKELQKIHQLELQTMKTQETG 1178

Query: 1132 EKDQCISELISR-----HEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSE 1186
            ++ + +  LI +      EE S  L+   + +   +  A + E N +          D E
Sbjct: 1179 DEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAE----------DKE 1228

Query: 1187 LSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSS-QEQDREQLIQKLNCEKDEAIQTA 1245
             S     ++E    Q+ +YE  +Q+ +++   L++   E+  + L+ +    K    QT 
Sbjct: 1229 NSGDYISENEDPELQDYRYE--VQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTD 1286

Query: 1246 LKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLE- 1304
              + +   E + KE  E +  + +Q+     ID       S + +L++   EE+ + LE 
Sbjct: 1287 GMKLEFGEENLPKEETEFLS-IHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELES 1345

Query: 1305 -------QLEEQEKRKNEEMQNVRTSLIAEQQT 1330
                   QL+E E+    E+  ++  L A  ++
Sbjct: 1346 LISSLQQQLKETEQNYEAEIHCLQKRLQAVSES 1378



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 85/415 (20%), Positives = 159/415 (38%), Gaps = 83/415 (20%)

Query: 1129 MTIEKDQCISELISRHEE-------ESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQS 1181
            + I++ QC    I+  +        ES I++   +   + H Q F +E  L+ +I     
Sbjct: 55   LNIDQSQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVE--LESEISTTAD 112

Query: 1182 KLDSEL---SALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEK 1238
               SE+   S + R        +EE++       E+  Q   +  E    +L  K     
Sbjct: 113  DCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGK----- 167

Query: 1239 DEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEE 1298
                Q  ++E  L RE+ E  +    + L+       AI    G  + L A LQ+  +E+
Sbjct: 168  ----QHEIEE--LNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREK 221

Query: 1299 KAKFLEQLE--EQEKRKNEEMQNVRTSLIAEQQTNFNT----------VLTREKMRKE-- 1344
                 E LE  EQ ++   + Q ++ S      T+ +T          +LT ++  +E  
Sbjct: 222  DETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQD 281

Query: 1345 NIINDLSDKLKS-TMQ-----------QQERDKDLIESLSED-----------RARLLEE 1381
            +++ D   K +  TMQ           + E+DK +  S  E+             +++EE
Sbjct: 282  HLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEE 341

Query: 1382 KKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETS 1441
            +KK  E   KL +                   A +L GE     V+   E +    M+  
Sbjct: 342  EKKTLELKDKLTT-------------------ADKLLGELQEQIVQKNQEIK---NMKLE 379

Query: 1442 MMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEKI 1496
            + + ++     SEE +++M     LQ +  ++ +    ++ Q M   + R  E++
Sbjct: 380  LTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIV-QRMEQETQRKLEQL 433


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  117 bits (293), Expect = 9e-26
 Identities = 144/590 (24%), Positives = 276/590 (46%), Gaps = 79/590 (13%)

Query: 847  IIEKVKCSLEITLKEKH----QKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCL 902
            +  KVK  L++T +E+      +ELL +K E + K++G   E EE E K ++L  E   L
Sbjct: 837  VFTKVKPLLQVTRQEEELQAKDEELLKVK-EKQTKVEG---ELEEMERKHQQLLEEKNIL 892

Query: 903  EEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDL 962
             E LQ +   FA  +  +  +         K  E+E I+H     ++E ++  +I+  + 
Sbjct: 893  AEQLQAETELFAEAEEMRARLAA-------KKQELEEILHDLESRVEEEEERNQILQNEK 945

Query: 963  KKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEE-----L 1017
            KK           ++A +Q LE+    +L++    R   + EKV  + ++   E     L
Sbjct: 946  KK-----------MQAHIQDLEE----QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLL 990

Query: 1018 KKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKIL 1077
            + +N + I + ++   + I E   QL E + K  +L+  R K EV ++  E      ++ 
Sbjct: 991  EDQNSKFIKE-KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEE-----RLK 1044

Query: 1078 LEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLM------TI 1131
             EE   Q+ E  K  L+ ET +L+ +I++L  +I +          EL+  +      T+
Sbjct: 1045 KEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETL 1104

Query: 1132 EKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALE 1191
             K+  + +++   + +   L+ +     +  N+A + +++L E++  L+++L+  L    
Sbjct: 1105 HKNNAL-KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTA 1163

Query: 1192 RQKDEKITQQEE-------------KYEAIIQNLEKDRQKLVSSQEQDREQLIQ----KL 1234
             Q++ +  +++E              +EA IQ++   RQ+  ++ E+  EQL Q    K 
Sbjct: 1164 AQQELRTKREQEVAELKKALEEETKNHEAQIQDM---RQRHATALEELSEQLEQAKRFKA 1220

Query: 1235 NCEKD-EAIQTALKEFKLEREV---VEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAE 1290
            N EK+ + ++T  KE   E +V   V+ E   K K L+ Q+ +  A  S        +AE
Sbjct: 1221 NLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAE 1280

Query: 1291 LQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVL--TREKMRKENIIN 1348
               KLQ E       LEE EK K  +      SL ++ Q     +   TR+K+   + I 
Sbjct: 1281 KASKLQNELDNVSTLLEEAEK-KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIR 1339

Query: 1349 DLSDKLKSTMQQQERDKDLIESLSED----RARLLEEKKKLEEEVSKLRS 1394
             L ++  S  +QQE +++  ++L +     +++L + KKK+++++  + S
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIES 1389



 Score =  107 bits (268), Expect = 7e-23
 Identities = 147/660 (22%), Positives = 296/660 (44%), Gaps = 108/660 (16%)

Query: 843  EIRNIIEKVKCSLEITLK--EKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELV 900
            +IRN  E +   LE  LK  EK ++EL   K + +G+   L  +  E + +I +LK +L 
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA 1086

Query: 901  CLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLE 960
              EE LQ      AL + + E +           L++   + +Q  E++E  +S +    
Sbjct: 1087 KKEEELQG-----ALARGDDETL------HKNNALKVVRELQAQIAELQEDFESEKASRN 1135

Query: 961  DLKKLHVENDEKLQLLRAELQ-SLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKK 1019
              +K   +  E+L+ L+ EL+ +L+ +  ++   T + + + E +K       +LEE  K
Sbjct: 1136 KAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKK-------ALEEETK 1188

Query: 1020 ENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLE 1079
             ++  I  +++ HA  ++E  +QL++ K         R K  +E   +  ETD  ++  E
Sbjct: 1189 NHEAQIQDMRQRHATALEELSEQLEQAK---------RFKANLEKNKQGLETDNKELACE 1239

Query: 1080 ESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISE 1139
                QQ   +K+  E + + L  ++ +L+ K+ +  +  +V LA                
Sbjct: 1240 VKVLQQ---VKAESEHKRKKLDAQVQELHAKVSE-GDRLRVELA---------------- 1279

Query: 1140 LISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKIT 1199
                  E+++ L+ EL+ V++L  +A +      +    L+S+L      L+ +     T
Sbjct: 1280 ------EKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEE-----T 1328

Query: 1200 QQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDE-AIQTALKEFKLEREVVEK 1258
            +Q+    + I+ LE+++  L   QE++ E    + N EK   A+Q+ L + K   + V+ 
Sbjct: 1329 RQKLNLSSRIRQLEEEKNSLQEQQEEEEE---ARKNLEKQVLALQSQLADTK---KKVDD 1382

Query: 1259 EL--LEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEE 1316
            +L  +E ++  + ++ K               AE   +  EEKA   ++LE+ + R  +E
Sbjct: 1383 DLGTIESLEEAKKKLLKD--------------AEALSQRLEEKALAYDKLEKTKNRLQQE 1428

Query: 1317 MQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDR- 1375
            + ++   L  ++Q   N  L +++ + + ++ +  +K  S    +ERD+   E+  ++  
Sbjct: 1429 LDDLTVDLDHQRQVASN--LEKKQKKFDQLLAE--EKSISARYAEERDRAEAEAREKETK 1484

Query: 1376 ----ARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADE 1431
                AR LEE  + +EE  +           + ++ +  G    EL  E  + A+E   E
Sbjct: 1485 ALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL--EKSKRALEQQVE 1542

Query: 1432 GRVDSAMETSMMSVQENIHMLSEEKQRIML--------LERTLQLKEEENKRLNQRLMSQ 1483
                  M T +  +++ +    + K R+ +         ER LQ ++E+N+   + L+ Q
Sbjct: 1543 -----EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQ 1597



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 159/745 (21%), Positives = 325/745 (43%), Gaps = 113/745 (15%)

Query: 823  RTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKN-------EYE 875
            R   +K++ D S  L+    E+ + ++      E  L+ K ++E+  LK         +E
Sbjct: 1134 RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE--LRTKREQEVAELKKALEEETKNHE 1191

Query: 876  GKLDGL-------IKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQN 928
             ++  +       ++E  E   + K+ K  L   ++ L+  + E A    E + +  ++ 
Sbjct: 1192 AQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELAC---EVKVLQQVKA 1248

Query: 929  EKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHL 988
            E + K  +++  +   + ++ E  + R  + E   KL  E D    LL    +  E+  +
Sbjct: 1249 ESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLL----EEAEKKGI 1304

Query: 989  KELEDTL----QVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQ 1044
            K  +D      Q++  QE  +  T  +++L    ++ ++  N +QE   E  +E  K L+
Sbjct: 1305 KFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE-EEARKNLE 1363

Query: 1045 ELKLKV-SDLSDTRCKLEVELALKEAETDEIKILLEESRAQQK------------ETLKS 1091
            +  L + S L+DT+ K++ +L   E+  +  K LL+++ A  +            E  K+
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN 1423

Query: 1092 LLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNIL 1151
             L+QE ++L  ++    Q +  N E  Q    +L     + +++ IS   +R+ EE +  
Sbjct: 1424 RLQQELDDLTVDLDHQRQ-VASNLEKKQKKFDQL-----LAEEKSIS---ARYAEERDRA 1474

Query: 1152 KAELN-KVTSLHNQAFEIEKNL--KEQIIELQSKLDSELSALERQKDE---KITQQEEKY 1205
            +AE   K T   + A  +E+ L  KE+      +L +++  L   KD+    + + E+  
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSK 1534

Query: 1206 EAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKE-----L 1260
             A+ Q +E+ R +L   +++ +     KL  E +     A  E  L+    + E     L
Sbjct: 1535 RALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL 1594

Query: 1261 LEKVKHLENQIA-----KSPAIDSTRG---DSSSLVAELQ--EKLQEEKAKFLEQLEEQE 1310
            +++V+ LE ++      ++ A+ S +    D   L A+++   K ++E  K L +L+ Q 
Sbjct: 1595 IKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQM 1654

Query: 1311 KRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRK--ENIINDLSDKLKSTMQ-----QQER 1363
            K    E++  R S    +   F      EK  K  E  I  L ++L S+ +     +QER
Sbjct: 1655 KDYQRELEEARAS----RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER 1710

Query: 1364 DK--DLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGES 1421
            D+  D I + +  ++ LL+EK++LE  +++L                           E 
Sbjct: 1711 DELADEITNSASGKSALLDEKRRLEARIAQLEEEL-----------------------EE 1747

Query: 1422 DRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLM 1481
            ++S +E  ++    + ++   ++ +     L+ E+      +   Q  E +NK L  +L 
Sbjct: 1748 EQSNMELLNDRFRKTTLQVDTLNAE-----LAAERSAAQKSDNARQQLERQNKELKAKL- 1801

Query: 1482 SQSMSSVSSRHSEKIAIRDFQVGDL 1506
             +   +V S+    I+  + ++G L
Sbjct: 1802 QELEGAVKSKFKATISALEAKIGQL 1826



 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 113/512 (22%), Positives = 221/512 (43%), Gaps = 91/512 (17%)

Query: 848  IEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQ 907
            +EK K +LE  ++E  + +L  L++E +   D  ++     +    + + +L   +E  Q
Sbjct: 1530 LEKSKRALEQQVEEM-RTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDE--Q 1586

Query: 908  NKDNEFALVKHEKEAVICLQNEKDQKLL------EMENIMHSQNCEIKELKQSREIVLED 961
            N++ +  L+K  +E    L++E+ Q+ L      +ME  +     +I+   ++R+ V++ 
Sbjct: 1587 NEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ 1646

Query: 962  LKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKEN 1021
            L+KL  +                                      M D++  LEE +   
Sbjct: 1647 LRKLQAQ--------------------------------------MKDYQRELEEARASR 1668

Query: 1022 QQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEES 1081
             +I  Q +ES        EK+L+ L+ ++  L +     E      E E DE+   +  S
Sbjct: 1669 DEIFAQSKES--------EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS 1720

Query: 1082 RAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELI 1141
             +      KS L  E   L   I++L +++++   N ++ L +     T++ D   +EL 
Sbjct: 1721 ASG-----KSALLDEKRRLEARIAQLEEELEEEQSNMEL-LNDRFRKTTLQVDTLNAELA 1774

Query: 1142 SRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQ 1201
            +   E S   K++ N    L  Q  E++  L+E    ++SK  + +SALE     KI Q 
Sbjct: 1775 A---ERSAAQKSD-NARQQLERQNKELKAKLQELEGAVKSKFKATISALE----AKIGQL 1826

Query: 1202 EEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELL 1261
            EE+ E   +       KLV   E+  +++  ++  E+  A Q         +E +EK   
Sbjct: 1827 EEQLEQEAKE-RAAANKLVRRTEKKLKEIFMQVEDERRHADQ--------YKEQMEK-AN 1876

Query: 1262 EKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVR 1321
             ++K L+ Q+ ++   ++TR ++S      + KLQ E    L+   E  +  + E+  ++
Sbjct: 1877 ARMKQLKRQLEEAEE-EATRANAS------RRKLQRE----LDDATEANEGLSREVSTLK 1925

Query: 1322 TSLIAEQQTNFNTVLT-REKMRKENIINDLSD 1352
              L      +F++  + R ++  E    +LSD
Sbjct: 1926 NRLRRGGPISFSSSRSGRRQLHLEGASLELSD 1957



 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 66/309 (21%), Positives = 143/309 (46%), Gaps = 41/309 (13%)

Query: 841  AVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELV 900
            A + R+ + K    L+  +K+ +Q+EL     E     D +  +++E+E K+K L+ E++
Sbjct: 1636 ANKARDEVIKQLRKLQAQMKD-YQREL----EEARASRDEIFAQSKESEKKLKSLEAEIL 1690

Query: 901  CLEEVLQNKDNEFALVKHEKEAV---ICLQNEKDQKLLEMENIMHSQNC----EIKELKQ 953
             L+E L + +      + E++ +   I         LL+ +  + ++      E++E + 
Sbjct: 1691 QLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQS 1750

Query: 954  SREIVLEDLKKLHVENDEKLQLLRAELQSLEQS-----HLKELEDTLQVRHIQEFE-KVM 1007
            + E++ +  +K  ++ D     L AE  + ++S      L+     L+ + +QE E  V 
Sbjct: 1751 NMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAK-LQELEGAVK 1809

Query: 1008 TDHRVSLEELKKENQQIINQIQESHAE------IIQEKEKQLQELKLKVSDLSDTRCKLE 1061
            +  + ++  L+ +  Q+  Q+++   E      +++  EK+L+E+ ++V D         
Sbjct: 1810 SKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVED--------- 1860

Query: 1062 VELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEIS--KLNQKIQDNNENYQ 1119
                 +    D+ K  +E++ A+ K+  + L E E E  R   S  KL +++ D  E  +
Sbjct: 1861 -----ERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANE 1915

Query: 1120 VGLAELRTL 1128
                E+ TL
Sbjct: 1916 GLSREVSTL 1924


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score =  117 bits (293), Expect = 9e-26
 Identities = 152/689 (22%), Positives = 307/689 (44%), Gaps = 100/689 (14%)

Query: 848  IEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQ 907
            +E +   LEI    KH ++++      E  L     E  E +  + + + EL C +E  +
Sbjct: 1398 VESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTK 1457

Query: 908  NKDNEFALVKHEKEAVICLQNEKDQKLLEM------------ENIMHSQNCEIKELKQSR 955
            N   +F   K        LQ E D + LE             +  + S   + K+L+Q +
Sbjct: 1458 NAVEKFTDAKRS-----LLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHK 1512

Query: 956  ---EIVLEDLKKLHVEND-------EKLQLLRAELQSLEQS-HLKELEDTLQVRHIQEFE 1004
               E +L+++ K+    D       +K + L  ELQ L++   + E  +   ++ ++E E
Sbjct: 1513 IKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESE 1572

Query: 1005 KVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVEL 1064
             ++   R  LE+LK    Q+ +Q QE  A + ++   + +EL L    +   +  L+  L
Sbjct: 1573 VLLQAKRAELEKLKS---QVTSQQQEM-AVLDRQLGHKKEELHLLQGSMVQAKADLQEAL 1628

Query: 1065 ALKEAETDE-------IKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNEN 1117
             L E E  E       +K LLEE   Q+ E     L  +    +T+++ + Q+I+   EN
Sbjct: 1629 RLGETEVTEKCNHIREVKSLLEELSFQKGE-----LNVQISERKTQLTLIKQEIEKEEEN 1683

Query: 1118 YQVGLAELRTLMTIEKDQCISELISRHEEESNILK-----AELNKV-TSLHNQAFEIEKN 1171
             QV L ++    T  K+      +  HE +   L+     +EL K   ++  +  E+E N
Sbjct: 1684 LQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELE-N 1742

Query: 1172 LKEQIIELQSKLDSELSALERQKDE--KITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQ 1229
            L++   + + +++ +   LER K E  ++T +    ++ ++ L K+++ L     Q++  
Sbjct: 1743 LQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDL-----QEKCD 1797

Query: 1230 LIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSL-- 1287
            + +K   +    +  A +  K+E+  +EK  L  V+ L+ ++      D    D  SL  
Sbjct: 1798 IWEKKLAQTKRVLAAAEENSKMEQSNLEKLELN-VRKLQQEL------DQLNRDKLSLHN 1850

Query: 1288 -VAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENI 1346
             ++ +Q++LQE K + +  L+E+     + +   +  L+    T    VL  E+ R +  
Sbjct: 1851 DISAMQQQLQE-KREAVNSLQEELANVQDHLNLAKQDLL--HTTKHQDVLLSEQTRLQKD 1907

Query: 1347 INDLSDKLKSTMQQQERDKDLIESLS----EDRARLLEEK-------KKLEEEVSKLRSS 1395
            I++ +++ +   +++E  +  ++ L     E++ +L++++       K+ E E SKL +S
Sbjct: 1908 ISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETS 1967

Query: 1396 SFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEE 1455
                     T  E       EL          T  + ++D  + + +++ +E +  L EE
Sbjct: 1968 K-------VTLKEQQHQLEKEL----------TDQKSKLDQVL-SKVLAAEERVRTLQEE 2009

Query: 1456 KQRIMLLERTLQLKEEENKRLNQRLMSQS 1484
            ++    LE+TL   + +     Q+L+ +S
Sbjct: 2010 ERWCESLEKTLSQTKRQLSEREQQLVEKS 2038



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 149/650 (22%), Positives = 292/650 (44%), Gaps = 83/650 (12%)

Query: 775  RRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFS 834
            RR Q+T V       +    + QL   +  A+D        +E L      V  +  DF 
Sbjct: 1482 RRAQETAV-------NLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDF- 1533

Query: 835  NSLKCTAVEIRNIIEKV-KCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIK 893
               +C + +   + E++ K   +I + E+++   L +  E E  L     E E+ ++++ 
Sbjct: 1534 ---QCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVT 1590

Query: 894  KLKGELVCLEEVLQNKDNEFALVKHEK-EAVICLQN----------EKDQKLLEMENIMH 942
              + E+  L+  L +K  E  L++    +A   LQ           EK   + E+++++ 
Sbjct: 1591 SQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLE 1650

Query: 943  SQ-------NCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTL 995
                     N +I E K    ++ ++++K     +E LQ++  ++ S  ++ LK + D L
Sbjct: 1651 ELSFQKGELNVQISERKTQLTLIKQEIEK----EEENLQVVLRQM-SKHKTELKNILDML 1705

Query: 996  QVR-HIQEFEKVMTDHRVSL----------EELKKENQQIINQIQESHAE----IIQEKE 1040
            Q+  H  +  K+  D RVS           E+L+ EN Q I+Q Q+   E    +++  +
Sbjct: 1706 QLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDK 1765

Query: 1041 KQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENL 1100
            ++++ +  +   L        VE   KE E  + K  + E +  Q    K +L    EN 
Sbjct: 1766 REIERMTAESRALQSC-----VECLSKEKEDLQEKCDIWEKKLAQT---KRVLAAAEENS 1817

Query: 1101 RTEISKLNQKIQDNNENYQVGLAEL-RTLMTIEKD-QCISELISRHEEESNILKAELNKV 1158
            + E S L +K++ N    Q  L +L R  +++  D   + + +    E  N L+ EL  V
Sbjct: 1818 KMEQSNL-EKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANV 1876

Query: 1159 TSLHNQAFE-IEKNLKEQIIEL--QSKLDSELSALER-----QKDEKITQQEEKYEAIIQ 1210
                N A + +    K Q + L  Q++L  ++S         QK+E+  QQ+ +   ++Q
Sbjct: 1877 QDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQ---VLQ 1933

Query: 1211 N-LEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLEN 1269
            N +E+++ KLV  Q++   Q +QK    ++  ++T+    K ++  +EKEL ++   L+ 
Sbjct: 1934 NEIEENKLKLV--QQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQ 1991

Query: 1270 QIAKSPAIDS---TRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNE--EMQNVRTSL 1324
             ++K  A +    T  +       L++ L + K +  E+ ++  ++  E   +Q    S+
Sbjct: 1992 VLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSM 2051

Query: 1325 IAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSED 1374
             A+     N  LT E+ + E  +  L + LK  +Q+ + +K+L+E   E+
Sbjct: 2052 RADFSLLRNQFLT-ERKKAEKQVASLKEALK--IQRSQLEKNLLEQKQEN 2098



 Score = 90.9 bits (224), Expect = 9e-18
 Identities = 123/600 (20%), Positives = 272/600 (45%), Gaps = 73/600 (12%)

Query: 931  DQKLLEMENIMH---SQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSH 987
            + ++  +E+IM    S+  E + ++ S+    +++++LH   D+ LQ    E +SLE   
Sbjct: 1322 ENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQ----EKKSLE-CE 1376

Query: 988  LKELEDTLQVRHIQE------FEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEK 1041
            ++EL  T+Q R  Q+       E +MT+  + +E+  K ++ I+++I+     +++ + +
Sbjct: 1377 VEELHRTVQKRQQQKDFIDGNVESLMTE--LEIEKSLKHHEDIVDEIECIEKTLLKRRSE 1434

Query: 1042 QLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLE-ESRAQQKETLKSLLEQETENL 1100
              +  +L     S+  C  E      E  TD  + LL+ ES A++       LE+  +  
Sbjct: 1435 LREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEE-------LERRAQET 1487

Query: 1101 RTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTS 1160
               + K +Q              +LR+L    KD      + +H+ +   +  E+NK+ +
Sbjct: 1488 AVNLVKADQ--------------QLRSLQADAKD------LEQHKIKQEEILKEINKIVA 1527

Query: 1161 LHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKL- 1219
              +  F+     KE++ E   KL  ++   ER +D  +   +E  E ++Q    + +KL 
Sbjct: 1528 AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKES-EVLLQAKRAELEKLK 1586

Query: 1220 --VSSQEQDREQLIQKLNCEKDE--AIQTALKEFKLERE----VVEKELLEKVKHLENQI 1271
              V+SQ+Q+   L ++L  +K+E   +Q ++ + K + +    + E E+ EK  H+    
Sbjct: 1587 SQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVK 1646

Query: 1272 AKSPAIDSTRGDSSSLVAE-------LQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSL 1324
            +    +   +G+ +  ++E       +++++++E+      L +  K K  E++N+   L
Sbjct: 1647 SLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKT-ELKNILDML 1705

Query: 1325 IAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKK 1384
              E     N  L   K++ +  +++L +K +  + +++ + + ++ +S+ +   +E +K+
Sbjct: 1706 QLE-----NHELQGLKLQHDQRVSEL-EKTQVAVLEEKLELENLQQISQQQKGEIEWQKQ 1759

Query: 1385 LEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMS 1444
            L E   +        S  + +  E       +L  + D    + A   RV +A E +   
Sbjct: 1760 LLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKM 1819

Query: 1445 VQENIHMLS----EEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEKIAIRD 1500
             Q N+  L     + +Q +  L R  +L    +    Q+ + +   +V+S   E   ++D
Sbjct: 1820 EQSNLEKLELNVRKLQQELDQLNRD-KLSLHNDISAMQQQLQEKREAVNSLQEELANVQD 1878



 Score = 89.4 bits (220), Expect = 3e-17
 Identities = 130/594 (21%), Positives = 268/594 (45%), Gaps = 102/594 (17%)

Query: 844  IRNIIEKVKCSLEITLKE--KHQKEL------LSLKN-EYEG---KLDGLIKETEENENK 891
            I+  IEK + +L++ L++  KH+ EL      L L+N E +G   + D  + E E+ +  
Sbjct: 1673 IKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVA 1732

Query: 892  IKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKEL 951
            + + K EL  L+++ Q +  E   ++ +K+ +   + E ++   E   +     C  KE 
Sbjct: 1733 VLEEKLELENLQQISQQQKGE---IEWQKQLLERDKREIERMTAESRALQSCVECLSKEK 1789

Query: 952  KQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHR 1011
            +  +E    D+ +  +   +++     E   +EQS+L++LE  L VR +Q+         
Sbjct: 1790 EDLQEKC--DIWEKKLAQTKRVLAAAEENSKMEQSNLEKLE--LNVRKLQQ--------- 1836

Query: 1012 VSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAET 1071
              L++L ++   + N I     ++ QEK + +  L+ +++++ D     + +L       
Sbjct: 1837 -ELDQLNRDKLSLHNDISAMQQQL-QEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQ 1894

Query: 1072 DEIKILLEESRAQQKETLKSL-----LEQETENLRTEISKLNQKIQDNNENYQVGLAELR 1126
            D   +LL E    QK+  +        ++E E  + ++  L  +I++N            
Sbjct: 1895 D---VLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENK----------- 1940

Query: 1127 TLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSE 1186
             L  ++++     L  + E ES   K E +KVT L  Q  ++EK L +Q  +L   L   
Sbjct: 1941 -LKLVQQEMMFQRL--QKERESEESKLETSKVT-LKEQQHQLEKELTDQKSKLDQVLSKV 1996

Query: 1187 LSALERQKDEKITQQEEKY-EAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKD------ 1239
            L+A ER +     Q+EE++ E++ + L + +++L   ++Q  E+  + L  +K+      
Sbjct: 1997 LAAEERVRT---LQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRA 2053

Query: 1240 ----------------EAIQTALKE-FKLEREVVEKELLEKVKHLENQIAKSPA-IDSTR 1281
                            E    +LKE  K++R  +EK LLE+ K   + I K  A I+   
Sbjct: 2054 DFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQ-KQENSCIQKEMATIELVA 2112

Query: 1282 GDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKM 1341
             D+      L ++L + + ++ E  ++   +K+ E + +  S               + M
Sbjct: 2113 QDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEIS---------------DAM 2157

Query: 1342 RKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSS 1395
            R   + +++ D+++++++   +    +  L  D   +LE  + LE E+  L+ +
Sbjct: 2158 R--TLKSEVKDEIRTSLKNLNQ---FLPELPADLEAILERNENLEGELESLKEN 2206



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 113/540 (20%), Positives = 244/540 (45%), Gaps = 45/540 (8%)

Query: 959  LEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELK 1018
            LED +K       +L  L  E++  EQ  L+  E+  Q+    + +K+    +  L +  
Sbjct: 439  LEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQL 498

Query: 1019 KENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILL 1078
                Q++N++++   ++  + EKQ QE+  K  ++ D +  ++  L  K+ +   +K   
Sbjct: 499  SGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAID-SLDSKDPKHSHMK-AQ 556

Query: 1079 EESRAQQKETLK---SLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQ 1135
            +  + QQ + +      LE   + + + I+K  ++I+D  E    G  ++     ++KD 
Sbjct: 557  KSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEG--QIAANEALKKD- 613

Query: 1136 CISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSK--------LDSEL 1187
             +  +IS  +E    +K +  +  +   +  + ++ L +++ E++ +        +D+E 
Sbjct: 614  -LEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAEN 672

Query: 1188 SALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKD---EAIQT 1244
               E  + E   Q++ +  A +Q  + D    +S+ E + E  +   + E +   E ++ 
Sbjct: 673  MRKELAELESALQEQHEVNASLQQTQGD----LSAYEAELEARLNLRDAEANQLKEELEK 728

Query: 1245 ALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLE 1304
              +  +LE+  ++ EL ++ + L+N + K+   +    ++S L A+L+  LQ++     +
Sbjct: 729  VTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKH-LQDDNNLLKQ 787

Query: 1305 QLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMR---KENIINDLSDKLKSTMQQQ 1361
            QL++ +   N    +V   L+  ++        R K++    E  I+  SD L  ++   
Sbjct: 788  QLKDFQNHLN----HVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSL--- 840

Query: 1362 ERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELY-GACAPELPGE 1420
                DL +  SE  AR   E+ + +    KL+    +    +AT  E +  AC   L  E
Sbjct: 841  ---ADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERAL--E 895

Query: 1421 SDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRL 1480
            +  +  +   E R+   ME  +  +QEN+  + E +    L +  LQ  +EE +R+  +L
Sbjct: 896  ARMNFDKRQHEARIQQ-MENEIHYLQENLKSMEEIQG---LTDLQLQEADEEKERILAQL 951



 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 147/729 (20%), Positives = 316/729 (43%), Gaps = 99/729 (13%)

Query: 791  HTSLNVQLE-------RCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVE 843
            HT L+ QLE         +    + H  I+  ++ +   R   + +Q + +  LK  +  
Sbjct: 432  HTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQI--LRATEEFKQLEEAIQLKKISEA 489

Query: 844  IRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLE 903
             ++++ K + S  + L  K ++E L L+ + E       K+ +E   K K++K   + ++
Sbjct: 490  GKDLLYK-QLSGRLQLVNKLRQEALDLELQME-------KQKQEIAGKQKEIKDLQIAID 541

Query: 904  EVLQNKDNEFALVKHEK---EAVICLQNEKDQKLL----EMENIMHSQNCEIKELKQ--- 953
              L +KD + + +K +K   E  + + N++ Q+L     E+ + +  +  EIK+L++   
Sbjct: 542  S-LDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLT 600

Query: 954  -----SREIVLEDLKKLHVENDEKLQLLRAELQSLEQS--HLKELEDTLQVR--HIQEFE 1004
                 + E + +DL+ +     E L  ++ +    +     L++ ++TL  R   +++  
Sbjct: 601  EGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQER 660

Query: 1005 KVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVEL 1064
              +    +  E ++KE  ++ + +QE H     E    LQ+ +    DLS    +LE  L
Sbjct: 661  DQLEIVAMDAENMRKELAELESALQEQH-----EVNASLQQTQ---GDLSAYEAELEARL 712

Query: 1065 ALKEAETDEIKILLEE-SRAQQKE--TLKSLLEQETENLRTEISKLNQKIQDNNENYQVG 1121
             L++AE +++K  LE+ +R  Q E   L++ LE+E + L+  + K     +   EN ++ 
Sbjct: 713  NLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELH 772

Query: 1122 LAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQ- 1180
             A+L+ L   + +  + + +   +   N +   L +   +  +  E+ + LK    E+  
Sbjct: 773  -AKLKHLQ--DDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNI 829

Query: 1181 ----SKLDSELSALERQKDEKITQQE-EKYEAII------QNLEKDRQKLVSSQEQDREQ 1229
                  L   L+ L++Q  E + + + E+ EA +      + +   ++KL + QE+ R+ 
Sbjct: 830  HSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQA 889

Query: 1230 LIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVA 1289
                  CE+  A++  +   K + E   +++  ++ +L+  +     I          + 
Sbjct: 890  ------CER--ALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQG--------LT 933

Query: 1290 ELQ-EKLQEEKAKFLEQLEEQEKRKNEE---MQNVRTSLIAEQQTNFNTVLTREKMRKEN 1345
            +LQ ++  EEK + L QL E EK+K  E    Q     L  E +     V T +K+    
Sbjct: 934  DLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAE 993

Query: 1346 IINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVAT 1405
             +    D+LKS           +  ++++RA  L+E ++   + ++           +  
Sbjct: 994  -LTIAKDQLKSL-------HGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIEL 1045

Query: 1406 APELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERT 1465
               L      +   E +++ V T    +V        + +++    +  ++  I  L+  
Sbjct: 1046 LQNLLRQKGEQFRLEMEKTGVGTGANSQV--------LEIEKLNETMERQRTEIARLQNV 1097

Query: 1466 LQLKEEENK 1474
            L L   +NK
Sbjct: 1098 LDLTGSDNK 1106



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 126/665 (18%), Positives = 275/665 (41%), Gaps = 55/665 (8%)

Query: 866  ELLSLKNEYEGKLDGL-----IKETEENENKIKKLKG-ELVCLEEVLQNKDNEFALV--- 916
            E+L+L     GK++ L     ++E   + NKI K++G E +C  + L    NE   +   
Sbjct: 128  EVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVW 187

Query: 917  ---KHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKL 973
               K +   V+ L+  K   L ++  +   Q+     L ++  + L    +  + +   L
Sbjct: 188  LGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSL 247

Query: 974  QLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHA 1033
            + L  E Q +     +E  +   +  ++  E+ +    +  EELK +  + + +I+    
Sbjct: 248  ESL--EGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQ-- 303

Query: 1034 EIIQEKEKQL-QELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSL 1092
                +  K L +E  L+     + +  L  +  L + +T E+    ++    ++E     
Sbjct: 304  ---DKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK 360

Query: 1093 LEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISEL----ISRHEEES 1148
            ++ + E L    S+  +  +  +E+  +G +  +  M   +   I       I + E + 
Sbjct: 361  IDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDE 420

Query: 1149 NILKAELN--KVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQ---KDEKITQQEE 1203
             +    +N    T L  Q  + EK +      L S+L  E+   E+Q     E+  Q EE
Sbjct: 421  QLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRL-SELHDEIEKAEQQILRATEEFKQLEE 479

Query: 1204 KYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVV--EKELL 1261
              +  ++ + +  + L+  Q   R QL+ KL   + EA+   L+  K ++E+   +KE+ 
Sbjct: 480  AIQ--LKKISEAGKDLLYKQLSGRLQLVNKL---RQEALDLELQMEKQKQEIAGKQKEIK 534

Query: 1262 EKVKHLENQIAKSPAIDSTRGDSSSLVAEL--QEKLQEEKAKFLEQLEEQEKRKNEEMQN 1319
            +    +++  +K P     +   S    +L    K  ++    L+++  +  ++ EE+++
Sbjct: 535  DLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKD 594

Query: 1320 VRTSLIAEQQTNFNTVLTREKMRK--ENIINDLSDKLKSTMQQQERDKDLIESLSEDRAR 1377
            +      E+Q     +   E ++K  E +I+ L + L +   Q  + ++    L +++  
Sbjct: 595  L------EEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKET 648

Query: 1378 LLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVET-ADEGRVDS 1436
            LL+   ++E+E  +L   +           EL  A   +   E + S  +T  D    ++
Sbjct: 649  LLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQ--HEVNASLQQTQGDLSAYEA 706

Query: 1437 AMETSMMSVQENIHMLSEEKQRI----MLLERTLQLK-EEENKRLNQRLMSQSMSSVSSR 1491
             +E  +       + L EE +++     L +  LQ + E+E + L   L     S    +
Sbjct: 707  ELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQ 766

Query: 1492 HSEKI 1496
             + ++
Sbjct: 767  ENSEL 771



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 82/396 (20%), Positives = 164/396 (41%), Gaps = 31/396 (7%)

Query: 1018 KKENQQIINQIQESHAEIIQEKEKQLQEL----KLKVSDLSDTRC----KLEVELALKEA 1069
            K++N  +I  +  S ++   +K K ++ L    KL+V +LS        KL+  L L+E 
Sbjct: 93   KQDNLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLREL 152

Query: 1070 ETDEIKILLEESRAQQKETLK-SLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTL 1128
                 KI   E         K +L   E E++   + K  + ++  N        ++ +L
Sbjct: 153  NLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGN----KISSL 208

Query: 1129 MTIEKDQCISELISRHEEESNILKA-ELNKVTSLHNQAFEIEKNLKEQIIELQSKLDS-- 1185
              I K + + +LIS    E+ ++      + T  H ++ E   +L+ Q +  Q + ++  
Sbjct: 209  QDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLE---SLEGQPVTTQDRQEAFE 265

Query: 1186 -----ELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDE 1240
                 E+  LER  ++K+ + EE      + LE+ + +   ++    E ++QK +CE+ +
Sbjct: 266  RFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELK 325

Query: 1241 AIQTALKEFKLEREVVEKELLEKVKHLENQIA--KSPAIDSTRGDSSSLVAELQEKLQEE 1298
            +      E   ++ +      +K   LE ++A  K  A         S  AE+ +   E 
Sbjct: 326  SDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDES 385

Query: 1299 ----KAKFLEQLEEQEKRKNEEMQNVR-TSLIAEQQTNFNTVLTREKMRKENIINDLSDK 1353
                K+++   +   E    +  Q V+   +  ++Q   + +  R     +  + D   K
Sbjct: 386  PYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKK 445

Query: 1354 LKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEV 1389
            + +   +     D IE   +   R  EE K+LEE +
Sbjct: 446  ISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAI 481


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score =  116 bits (290), Expect = 2e-25
 Identities = 174/794 (21%), Positives = 331/794 (41%), Gaps = 170/794 (21%)

Query: 859  LKEKHQKELLSLKN------EYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNE 912
            L+EK+   LLSL        E EGK++ L +E ++  NK+K    E+    +  + ++  
Sbjct: 564  LQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERL 623

Query: 913  FALVKHEKEAVICLQNEKDQKLLEM---------ENIMHSQNCE-----IKELKQSREIV 958
               +  + E  I   +E +QK+ E+         E   + Q  E     +K L + +E++
Sbjct: 624  ILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVL 683

Query: 959  LEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEK---VMTDHRVSLE 1015
              ++K L+ EN+ KL   + +L    +  L + ED +   HI + EK   +M + + +L 
Sbjct: 684  SAEVKSLYEENN-KLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLN 742

Query: 1016 ELKKENQ--------QIINQIQESHAEIIQEKEKQ-----LQELKLKVSDLSDTRCKLEV 1062
            +L +  Q        Q+   ++E  +E+ ++ E++     LQ +   ++ +++ +C L  
Sbjct: 743  KLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAF 802

Query: 1063 ELALKEAETD-EIKILLEESRAQQKETLKSLL---EQETENLRTEISKL----------- 1107
            +   K  E + EIK L EES  Q +E LKSLL   EQE   LR E+ ++           
Sbjct: 803  QRDEKVLELEKEIKCLQEESVVQCEE-LKSLLRDYEQEKVLLRKELEEIQSEKEALQSDL 861

Query: 1108 ------NQKIQDNNENYQVGLAEL-----RTLMTIEKDQCISELISRHEE---------- 1146
                  N+K +  N+N  + + E+     ++ +  EK++C    I  HE           
Sbjct: 862  LEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCF---IKEHENLKPLLEQKEL 918

Query: 1147 -----ESNILKAELNKVTSLHNQAFEIEKNLKEQI---------------------IELQ 1180
                 E  +LK  L K  S+ N      K L+E+I                     ++ +
Sbjct: 919  RDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAK 978

Query: 1181 SKLDS----------ELSALERQKDE------KITQQEEKYEAIIQNLEKDRQKLVSSQE 1224
             +LDS          EL +L  +KD+       + Q  E Y+ ++   EK  ++L   +E
Sbjct: 979  KELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKE 1038

Query: 1225 Q---------------------------DREQLIQKLNCEKDEA--IQTALKEFKLEREV 1255
            +                           D E L+ ++   +  A  ++  + E +  + +
Sbjct: 1039 RANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAM 1098

Query: 1256 VEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNE 1315
            V+KEL  +    E +I +          + + + ELQ +LQ+EK +  + ++E E  K +
Sbjct: 1099 VDKELEAEKLQKEQKIKE-------HATTVNELEELQVQLQKEKKQLQKTMQELELVKKD 1151

Query: 1316 EMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDR 1375
              Q    ++           L ++   K N I DL  ++K   Q+QE  ++ I SL    
Sbjct: 1152 AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSV 1211

Query: 1376 ARLLEEKKKLEEEVSK----LRSSSFVPSPYVATAPELYG---ACAPELPGESDRSAVET 1428
             +  E+  K+++ + K    L  S    + ++     L G   A   ++     + A  T
Sbjct: 1212 QQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEIT 1271

Query: 1429 ADEGRVDSAMETS-------MMSVQENIHMLSEEKQRIMLLERTLQLKEEENK-RLNQRL 1480
            +++ ++   ++TS       + + Q+ +  L EE +     + T+  + E  K R++  L
Sbjct: 1272 SEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVL 1331

Query: 1481 MSQSMSSVSSRHSE 1494
              Q   S+S   +E
Sbjct: 1332 KQQKNKSMSQAETE 1345



 Score =  104 bits (260), Expect = 6e-22
 Identities = 147/705 (20%), Positives = 313/705 (44%), Gaps = 97/705 (13%)

Query: 836  SLKCTAVEIRNIIEKVKCSLEITLKEKHQ------KELLSLKNEYEGKLDGLIKETEENE 889
            SLK   ++++  +E     +    KE  Q      KE+ +LKNE         ++    +
Sbjct: 94   SLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQ 153

Query: 890  NKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIK 949
             ++++     + L E L+ ++N    VK  +E +  ++   ++++L ++  + +   E K
Sbjct: 154  KQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKK 213

Query: 950  ELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTD 1009
            E     + ++E   + + +N   LQ    +L+++ Q  +KEL        + + E    +
Sbjct: 214  ETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKEL--------MCQIEASAKE 265

Query: 1010 HRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTR--CK--LEVELA 1065
            H   + +L +  + ++ Q + S   I ++ E +L+ L+   S+ +     C   L+    
Sbjct: 266  HEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTF 325

Query: 1066 LKEAETDEIKILLEESRAQQKETLKSLLEQET---ENLRTEISKLNQKIQD----NNENY 1118
            +++   +++K L  E   ++ E+  S+L+ E     NL+ ++    Q I+D      E+ 
Sbjct: 326  VEQVVNEKVKHL--EDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDL 383

Query: 1119 QVGLAELRTLMTIEKDQCISE---------------LISRHEEESNILKAELNKVTSLHN 1163
            +  + EL  L+  E+  C+ E                + +H  E   LK +  K  S  N
Sbjct: 384  EFKINEL--LLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELN 441

Query: 1164 QAF--EIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYE--AIIQ--------N 1211
            + F  + EK     + E+Q  L  +   L+++K E I   E   E   I+Q         
Sbjct: 442  ETFLSDSEKEKLTLMFEIQG-LKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGK 500

Query: 1212 LEKDRQKLVSSQEQDREQLIQKLN---CEKDEAIQTALK-EFKLEREVVEKELLEKVKH- 1266
            + ++ + +   Q  D  +L QKL     EKD  ++T  + + + E+ + ++EL+ ++++ 
Sbjct: 501  ISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENT 560

Query: 1267 LENQIAKSPAIDSTRGDSSSLVAELQEK---LQEEKAKFLEQLEEQEKRKNEEMQNVRTS 1323
            ++N   K+     +     +++ EL+ K   L EEK  F+ +L    K  +EEM N    
Sbjct: 561  IKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKL----KNSHEEMDNFH-- 614

Query: 1324 LIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKK 1383
                          ++  R+E +I +L  K++ T+Q     +  +  L+      L+EK 
Sbjct: 615  --------------KKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKD 660

Query: 1384 KLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMM 1443
            + ++++ KL     V    ++   E+  A    L  E+++    ++++ ++   +E   +
Sbjct: 661  QNDQKLEKL----MVQMKVLSEDKEVLSAEVKSLYEENNKL---SSEKKQLSRDLEV-FL 712

Query: 1444 SVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSV 1488
            S +E++ +    K+ I  LE+ LQL  EE   LN+ L ++ +  +
Sbjct: 713  SQKEDVIL----KEHITQLEKKLQLMVEEQDNLNKLLENEQVQKL 753



 Score = 97.4 bits (241), Expect = 9e-20
 Identities = 182/786 (23%), Positives = 323/786 (41%), Gaps = 129/786 (16%)

Query: 722  DSLAESP--ESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINA---IDSRR 776
            DSLA+SP  ++D +S+V E  +EE +   N   + +  E  +  +    + A   +DS R
Sbjct: 930  DSLAKSPSVKNDPLSSVKE--LEEKIE--NLEKECKEKEEKINKIKLVAVKAKKELDSSR 985

Query: 777  MQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDF--- 833
             +   V  KE+     SL  + ++     +D     ++ K  L  +    Q EQ D    
Sbjct: 986  KETQTV--KEEL---ESLRSEKDQLSASMRDLIQGAESYKNLLLEYEK--QSEQLDVEKE 1038

Query: 834  -----------------SNSLKCTAVEIRNI-----IEKVKCS---LEITLKEKHQ---- 864
                             +++L+C  +   N      IE ++ +   LE+ + E  +    
Sbjct: 1039 RANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAM 1098

Query: 865  --KELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEA 922
              KEL + K + E K    IKE     N++++L+ +L   ++ LQ    E  LVK + + 
Sbjct: 1099 VDKELEAEKLQKEQK----IKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQ 1154

Query: 923  VIC----------LQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEK 972
                         L  E +QKL    N +     EIK  KQ +E + E++  L   + ++
Sbjct: 1155 TTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQ-SSVQQ 1213

Query: 973  LQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKE---NQQIINQIQ 1029
             +    +++ L     KEL D+ Q           TDH +    LK E   +QQ +   +
Sbjct: 1214 YEEKNTKIKQLLVKTKKELADSKQAE---------TDHLILQASLKGELEASQQQVEVYK 1264

Query: 1030 ESHAEIIQEKEKQLQELKL--------------KVSDLSDTRCKLEVELALKEAETDEIK 1075
               AEI  EK K  + LK               +V+ L +     + E A   +E +  K
Sbjct: 1265 IQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYK 1324

Query: 1076 ILLEESRAQQKETLKSLLE-----QETENLRTEISKLNQKIQDNNENYQVGLAELRTLMT 1130
            + +     QQK    S  E     QE E+L   I +L  K+QD+  N Q+ ++EL+TL +
Sbjct: 1325 VRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQS 1384

Query: 1131 IEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKN---LKEQIIELQSKLDSEL 1187
             E D     L+ RH   + +L+  ++K   L  +   I+     +K +  +  S+L S+ 
Sbjct: 1385 -EHD----TLLERH---NKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQN 1436

Query: 1188 SALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALK 1247
              L     +++   +E++   ++ L    Q+ +S  E    QL  +       + Q +LK
Sbjct: 1437 EVLRNSFRDQVRHLQEEHRKTVETL----QQQLSKMEAQLFQLKNEPTTRSPVSSQQSLK 1492

Query: 1248 EFKLEREVVEKELLE--KVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQ 1305
              + ER   +  LL+   V   E +  ++   +S    +S+    L++ L   + K    
Sbjct: 1493 NLR-ERRNTDLPLLDMHTVTREEGEGMETTDTESV-SSASTYTQSLEQLLNSPETKLEPP 1550

Query: 1306 LEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDK 1365
            L   E  K E +Q + ++  +    N    L RE      I+ +    LKS +++ ER++
Sbjct: 1551 LWHAEFTKEELVQKLSSTTKSADHLN---GLLRETEATNAILMEQIKLLKSEIRRLERNQ 1607

Query: 1366 DLIESLSEDRARLLEEKKKLEEEVSKLRSSSF------VPSPYVATAPELYGACAPELPG 1419
            +      E  A  LE  K +  +   L+  S       V +  +  +PE  G  A    G
Sbjct: 1608 E-----REKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQG 1662

Query: 1420 ESDRSA 1425
            E + ++
Sbjct: 1663 EEENAS 1668



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 99/460 (21%), Positives = 188/460 (40%), Gaps = 60/460 (13%)

Query: 1059 KLEVELALKEAETDEIKILLEESRAQQKETLKSL-LEQETENLRTEISKLNQKIQDNNEN 1117
            K ++E   KE   D IK   ++    QK   +   LE+E E LR++       + +   +
Sbjct: 19   KSKLETLPKE---DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSK------PVTEGTGD 69

Query: 1118 YQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQII 1177
                L E    + +EK +   + +S  +E   + +   + VT + +   E+E++    + 
Sbjct: 70   IIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVK 129

Query: 1178 ELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCE 1237
            E+++  +  ++   +  ++K   Q++  EA+   LE   Q    +  +D  + +Q    E
Sbjct: 130  EIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQ----E 185

Query: 1238 KDEAIQTALKE----FKLEREVVEKELLEKVKHLENQIAKSPA-----IDSTRGDSSSLV 1288
            + E I+   +E     + + +    E  E V  L+N I  +       I+S + +   L 
Sbjct: 186  EIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLK 245

Query: 1289 AELQE---------------------KLQEEKAKFLEQLEEQEK---RKNE-EMQNVRTS 1323
            A  QE                     KL E K   ++Q E  EK   +K E E++N+R +
Sbjct: 246  AIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKA 305

Query: 1324 LI-AEQQTNFNTVLTREKMRKENIIND----LSDKLKSTMQQQERDKDLIESLSEDRARL 1378
               A Q     ++L +E    E ++N+    L D LK    Q    KD +  ++  + +L
Sbjct: 306  TSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKL 365

Query: 1379 LEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGE---SDRSAVETADE--GR 1433
              + + +++E    R         +  A E  G    +L  E    ++    T ++    
Sbjct: 366  EMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNRE 425

Query: 1434 VDSAMETSMMSVQE-NIHMLSE-EKQRIMLLERTLQLKEE 1471
            V S  E     + E N   LS+ EK+++ L+     LKE+
Sbjct: 426  VQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQ 465


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score =  115 bits (288), Expect = 3e-25
 Identities = 194/884 (21%), Positives = 354/884 (40%), Gaps = 200/884 (22%)

Query: 794  LNVQLERCRVVAQDSHFSIQTIKEDLC---------HFRTFVQKEQCDFSNSLKCTAVEI 844
            L  +LE  RV        I  +++DL            R    K   D   SL     EI
Sbjct: 483  LQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQ-EI 541

Query: 845  RNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEE 904
             ++ EK    LE+T +  HQ+E+ SLK  +  + +   KE +      +KL  E   L+ 
Sbjct: 542  SSLQEK----LEVT-RTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKS 596

Query: 905  VLQ--NKDNE--FALVKHEKEAVICLQNEKDQKLL------------------------- 935
             L+  NK+N    AL K + E  I    +  ++L                          
Sbjct: 597  KLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMR 656

Query: 936  -----EMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKE 990
                 E+EN+ + Q+ E     +  E +   L K+  E +  L+ +R++L   E  HL E
Sbjct: 657  LDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVE 716

Query: 991  LEDTL--------QVRHIQ-------EFEKVMTDHRVSLE-------------------- 1015
            +EDTL        +V+ ++       E  KV+ +    L+                    
Sbjct: 717  MEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGK 776

Query: 1016 -ELKKENQQI-INQIQESHAEI---------------IQEKEKQLQELKLKVSDLSDTRC 1058
             E+KK  QQ+   + Q  H EI               +Q +E +L  L+  +S++S  + 
Sbjct: 777  SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE 836

Query: 1059 KLEVELAL---KEAETDEIKILLEES------RAQQKETLKSLLEQETENLRTEISKLNQ 1109
             LE EL +   K AE  E  + ++ S      +  QKE   ++L  + E LR  ++ +  
Sbjct: 837  TLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEA 896

Query: 1110 KIQDNN----------ENYQVGLAELR----------TLMTIE---KDQCISEL---ISR 1143
            K ++ +          E  +  +AE+           T M  E   K++ + EL   +++
Sbjct: 897  KFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK 956

Query: 1144 HEEESNILKAELNKVTSLHNQA--------FEIEKNLKEQIIELQSKLD---SELSALER 1192
              E ++ L+  +  +T    Q+         E +K L+ ++ +L+ K++   ++   L+ 
Sbjct: 957  ANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKA 1016

Query: 1193 QKDEKITQQEEKYEAIIQNLEK---DRQKLVSSQEQDREQLIQKL-----NCEKDEAIQT 1244
            + +   ++ + K+E I+QNL+K   D +  +    ++   L+Q+L       +K +A QT
Sbjct: 1017 RYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQT 1076

Query: 1245 ALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLE 1304
            A    ++  E + KE  E +  LE              D+    A+LQ +L   K   L+
Sbjct: 1077 AEDAMQI-MEQMTKEKTETLASLE--------------DTKQTNAKLQNELDTLKENNLK 1121

Query: 1305 QLEEQEKRK------NEEMQNVRTSL-----IAEQQTNFNTVLTREKMRKENIINDLSDK 1353
             +EE  K K      N++M+  R  +      A Q++   + L  E ++    +    D+
Sbjct: 1122 NVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDE 1181

Query: 1354 LKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGAC 1413
            + S  + +E    L   L E + R  +  K  +EE + L+ S  + S  +          
Sbjct: 1182 VTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLT--------- 1232

Query: 1414 APELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEEN 1473
                  E D    +  +E  V      S  S+   +  L  +K ++ L  + L+L+ +EN
Sbjct: 1233 ------EKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKEN 1286

Query: 1474 KRLNQRLMSQSMSSVSSRHSEKIAIRDFQVGDLVLIILDERHDN 1517
            K    R +S S  +  ++  E    ++ Q+  L  +I+D +  N
Sbjct: 1287 K----RQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKN 1326



 Score = 85.5 bits (210), Expect = 4e-16
 Identities = 136/612 (22%), Positives = 250/612 (40%), Gaps = 111/612 (18%)

Query: 963  KKLHVEND-EKLQLLRAELQSLEQSHLKELEDTLQV------RHIQEFEKVMTDHRVSLE 1015
            K+ H+E    +  L RAE+     SH+ E+E  L +      +H+ E E  M   R  +E
Sbjct: 360  KQQHIEQLLAERDLERAEVAKAT-SHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVE 418

Query: 1016 ELKKENQQIINQIQESHAEI---------------------------IQEKEKQLQELKL 1048
               +E  +++NQ++E   ++                           I+E E+ L   K 
Sbjct: 419  AADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKT 478

Query: 1049 KVS----DLSDTR----------CKLEVELALKEAETDEIKILLEESR-----------A 1083
            K      +L DTR           +LE +LAL+  E  E++  LE ++            
Sbjct: 479  KADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLL 538

Query: 1084 QQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTL---MTIEKDQCISEL 1140
            Q+  +L+  LE    + + EI+ L +      E +Q  +  L T    ++ E +   S+L
Sbjct: 539  QEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKL 598

Query: 1141 ISRHEEESNIL---KAELNKVTSLHNQAFEIEK---------------NLKEQIIELQSK 1182
               ++E S+++   K++L    + H QA E  K                LK QI +++  
Sbjct: 599  EHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLD 658

Query: 1183 LDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKD--- 1239
               E+  L+ Q+D +     ++ EA+   L     K++  +E   E +  KL+  +D   
Sbjct: 659  YQHEIENLQNQQDSERAAHAKEMEALRAKL----MKVIKEKENSLEAIRSKLDKAEDQHL 714

Query: 1240 ---EAIQTALKEFKL---EREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQE 1293
               E     L+E ++   E EV++ +  E+ K ++N  ++  A +    D  +L     E
Sbjct: 715  VEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSE 774

Query: 1294 KLQEEKAKFLEQLEEQEKR-KNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSD 1352
               E K K  +QLE  EK+ K+ E++    S  A         +TRE   +E  + +L +
Sbjct: 775  GKSEMK-KLRQQLEAAEKQIKHLEIEKNAESSKASS-------ITRELQGRELKLTNLQE 826

Query: 1353 KLKSTMQQQERDKDLIESLSEDRARLLEE----KKKLEEEVSKLRSSSFVPSPYVATAPE 1408
             L    Q +E  +  ++ L E  A   EE    ++ ++E V+KL       +   +   +
Sbjct: 827  NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK 886

Query: 1409 LYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQL 1468
            L       L     +   +   E ++  A E     + E + M  +   ++  +   L+L
Sbjct: 887  L----RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL 942

Query: 1469 KEEENKRLNQRL 1480
            KE + + L  +L
Sbjct: 943  KERDVEELQLKL 954



 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 92/413 (22%), Positives = 175/413 (42%), Gaps = 78/413 (18%)

Query: 1132 EKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLK-------EQIIELQSKLD 1184
            EK Q I +L++  + E    +AE+ K TS      EIE+ L        + ++EL++K+D
Sbjct: 359  EKQQHIEQLLAERDLE----RAEVAKATS---HVGEIEQELALARDGHDQHVLELEAKMD 411

Query: 1185 SELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQT 1244
               + +E    EK+         ++  LE++++K+   Q +  E+ I K + E    ++ 
Sbjct: 412  QLRTMVEAADREKV--------ELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEH 463

Query: 1245 A-LKEF------------KLEREV----------------VEKELLEKVKHLENQIAKSP 1275
            A +KE             KL+RE+                +EK+L  +V+ +  ++ +  
Sbjct: 464  ARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVA-ELRRRL 522

Query: 1276 AIDSTRGD---SSSLVAE---LQEKL-------QEEKAKFLEQLEEQEKRKNEEMQNVRT 1322
              +   GD   S SL+ E   LQEKL       Q E     E    +E+   +E++ + T
Sbjct: 523  ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYT 582

Query: 1323 SLIAEQQTNFNTVLTREKMRKEN--IINDLSDKLKSTM-QQQERDKDLIESLSEDRARLL 1379
            +     + N +     E   KEN  +I     KL++ +   Q+  ++L  S S+      
Sbjct: 583  ATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTET 642

Query: 1380 EEKKKLEEEVSKLR---------SSSFVPSPYVATAPELYGACAPELPGESDRSAVETAD 1430
             E  +L+ ++ K+R           +   S   A A E+    A  +    ++     A 
Sbjct: 643  AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAI 702

Query: 1431 EGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQ 1483
              ++D A +  ++ +++ ++ L E + ++  LE  LQ K  E  ++     SQ
Sbjct: 703  RSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELE-VLQAKCNEQTKVIDNFTSQ 754


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score =  115 bits (287), Expect = 4e-25
 Identities = 181/826 (21%), Positives = 337/826 (40%), Gaps = 190/826 (23%)

Query: 843  EIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCL 902
            EI ++ EK    LE+T +  HQ+E+ SLK  +  + +   KE +      +KL  E   L
Sbjct: 505  EISSLQEK----LEVT-RTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESL 559

Query: 903  EEVLQ--NKDNE--FALVKHEKEAVICLQNEKDQKLL----------------------- 935
            +  L+  NK+N    AL K + E  I    +  ++L                        
Sbjct: 560  KSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEK 619

Query: 936  -------EMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHL 988
                   E+EN+ + Q+ E     +  E +   L K+  E +  L+ +R++L   E  HL
Sbjct: 620  MRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHL 679

Query: 989  KELEDTL--------QVRHIQ-------EFEKVMTDHRVSLE------------------ 1015
             E+EDTL        +V+ ++       E  KV+ +    L+                  
Sbjct: 680  VEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSE 739

Query: 1016 ---ELKKENQQI-INQIQESHAEI---------------IQEKEKQLQELKLKVSDLSDT 1056
               E+KK  QQ+   + Q  H EI               +Q +E +L  L+  +S++S  
Sbjct: 740  GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQV 799

Query: 1057 RCKLEVELAL---KEAETDEIKILLEES------RAQQKETLKSLLEQETENLRTEISKL 1107
            +  LE EL +   K AE  E  + ++ S      +  QKE   ++L  + E LR  ++ +
Sbjct: 800  KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADM 859

Query: 1108 NQKIQDNN----------ENYQVGLAELR----------TLMTIE---KDQCISEL---I 1141
              K ++ +          E  +  +AE+           T M  E   K++ + EL   +
Sbjct: 860  EAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKL 919

Query: 1142 SRHEEESNILKAELNKVTSLHNQA--------FEIEKNLKEQIIELQSKLD---SELSAL 1190
            ++  E ++ L+  +  +T    Q+         E +K L+ ++ +L+ K++   ++   L
Sbjct: 920  TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL 979

Query: 1191 ERQKDEKITQQEEKYEAIIQNLEK---DRQKLVSSQEQDREQLIQKL-----NCEKDEAI 1242
            + + +   ++ + K+E I+QNL+K   D +  +    ++   L+Q+L       +K +A 
Sbjct: 980  KARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAA 1039

Query: 1243 QTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKF 1302
            QTA    ++  E + KE  E +  LE              D+    A+LQ +L   K   
Sbjct: 1040 QTAEDAMQI-MEQMTKEKTETLASLE--------------DTKQTNAKLQNELDTLKENN 1084

Query: 1303 LEQLEEQEKRK------NEEMQNVRTSL-----IAEQQTNFNTVLTREKMRKENIINDLS 1351
            L+ +EE  K K      N++M+  R  +      A Q++   + L  E ++    +    
Sbjct: 1085 LKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSR 1144

Query: 1352 DKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYG 1411
            D++ S  + +E    L   L E + R  +  K  +EE + L+ S  + S  +        
Sbjct: 1145 DEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLT------- 1197

Query: 1412 ACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEE 1471
                    E D    +  +E  V      S  S+   +  L  +K ++ L  + L+L+ +
Sbjct: 1198 --------EKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLK 1249

Query: 1472 ENKRLNQRLMSQSMSSVSSRHSEKIAIRDFQVGDLVLIILDERHDN 1517
            ENK    R +S S  +  ++  E    ++ Q+  L  +I+D +  N
Sbjct: 1250 ENK----RQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKN 1291



 Score =  110 bits (274), Expect = 1e-23
 Identities = 134/624 (21%), Positives = 286/624 (45%), Gaps = 51/624 (8%)

Query: 804  VAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNI-IEKVKCSLEITLKEK 862
            V ++   S++ I+  L         E  D  N L+   ++++ + + + KC+ +  + + 
Sbjct: 656  VIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDN 715

Query: 863  HQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEA 922
               +L + + +    LD L K + E ++++KKL+ +L   E+ +++ + E      E   
Sbjct: 716  FTSQLKATEEKLLD-LDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE---KNAESSK 771

Query: 923  VICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVE-NDEKLQLLRAELQ 981
               +  E   + L++ N+  + + E+ ++K++ E  L+ LK+   E ++E + + R+  +
Sbjct: 772  ASSITRELQGRELKLTNLQENLS-EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE 830

Query: 982  SLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEK 1041
            ++ + H KE +  +    +++  + + D      E  +  +Q+I        +  ++ E 
Sbjct: 831  TVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLI--------KAKEKLEN 882

Query: 1042 QLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLR 1101
             + E+     D S    K+  EL LKE + +E+++ L ++  +    L+  +E  T    
Sbjct: 883  DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKAN-ENASFLQKSIEDMTVKAE 941

Query: 1102 TEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVT-S 1160
                +  +K ++  +  +  L++L   M    +QC  EL +R+E  ++  K +  ++  +
Sbjct: 942  QSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQC-QELKARYERATSETKTKHEEILQN 1000

Query: 1161 LHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDE-KITQQEEKYEAIIQNLEKDRQKL 1219
            L     + E  LK    E  S L  EL  L +Q D+ K  Q  E    I++ + K++ + 
Sbjct: 1001 LQKTLLDTEDKLKGAREE-NSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTET 1059

Query: 1220 VSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELL----EKVKHLENQIA--- 1272
            ++S E D +Q   KL  E D   +  LK   +E     KELL    +K++    +I    
Sbjct: 1060 LASLE-DTKQTNAKLQNELDTLKENNLKN--VEELNKSKELLTVENQKMEEFRKEIETLK 1116

Query: 1273 -----KSPAIDSTRGDSSSLVAEL---------QEKLQEEKAKFLEQLEEQEKRKNEEMQ 1318
                 KS  + + + ++  L  EL          +KL+EE++    QL E +KR+++ ++
Sbjct: 1117 QAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIK 1176

Query: 1319 NVRTSLIAEQQTNFNT--VLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRA 1376
            +      + Q++   T  +LT +    E + N+++  L+      +    ++++L  D+ 
Sbjct: 1177 DADEEKASLQKSISITSALLTEKDAELEKLRNEVT-VLRGENASAKSLHSVVQTLESDKV 1235

Query: 1377 RLLEEKKKLE----EEVSKLRSSS 1396
            +L  + K LE    E   +L SSS
Sbjct: 1236 KLELKVKNLELQLKENKRQLSSSS 1259



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 130/577 (22%), Positives = 250/577 (43%), Gaps = 76/577 (13%)

Query: 963  KKLHVEND-EKLQLLRAELQSLEQSHLKELEDTLQV------RHIQEFEKVMTDHRVSLE 1015
            K+ H+E    +  L RAE+     SH+ E+E  L +      +H+ E E  M   R  +E
Sbjct: 360  KQQHIEQLLAERDLERAEVAKAT-SHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVE 418

Query: 1016 ELKKENQQIINQIQESHAEI----IQEKEKQLQELKLKVSDLSDTR--CKLEVELALKEA 1069
               +E  +++NQ++E   ++     + +E+ + +  L+V+ +S+     +LE +LAL+  
Sbjct: 419  AADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQ 478

Query: 1070 ETDEIKILLEESR-----------AQQKETLKSLLEQETENLRTEISKLNQKIQDNNENY 1118
            E  E++  LE ++            Q+  +L+  LE    + + EI+ L +      E +
Sbjct: 479  EVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETH 538

Query: 1119 QVGLAELRTL---MTIEKDQCISELISRHEEESNIL---KAELNKVTSLHNQAFEIEK-- 1170
            Q  +  L T    ++ E +   S+L   ++E S+++   K++L    + H QA E  K  
Sbjct: 539  QKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVS 598

Query: 1171 -------------NLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQ 1217
                          LK QI +++     E+  L+ Q+D +     ++ EA+   L     
Sbjct: 599  FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKL----M 654

Query: 1218 KLVSSQEQDREQLIQKLNCEKD------EAIQTALKEFKL---EREVVEKELLEKVKHLE 1268
            K++  +E   E +  KL+  +D      E     L+E ++   E EV++ +  E+ K ++
Sbjct: 655  KVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVID 714

Query: 1269 NQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKR-KNEEMQNVRTSLIAE 1327
            N  ++  A +    D  +L     E   E K K  +QLE  EK+ K+ E++    S  A 
Sbjct: 715  NFTSQLKATEEKLLDLDALRKASSEGKSEMK-KLRQQLEAAEKQIKHLEIEKNAESSKAS 773

Query: 1328 QQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEE----KK 1383
                    +TRE   +E  + +L + L    Q +E  +  ++ L E  A   EE    ++
Sbjct: 774  S-------ITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQR 826

Query: 1384 KLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMM 1443
             ++E V+KL       +   +   +L       L     +   +   E ++  A E    
Sbjct: 827  SMQETVNKLHQKEEQFNMLSSDLEKL----RENLADMEAKFREKDEREEQLIKAKEKLEN 882

Query: 1444 SVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRL 1480
             + E + M  +   ++  +   L+LKE + + L  +L
Sbjct: 883  DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKL 919



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 81/380 (21%), Positives = 164/380 (43%), Gaps = 47/380 (12%)

Query: 1132 EKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLK-------EQIIELQSKLD 1184
            EK Q I +L++  + E    +AE+ K TS      EIE+ L        + ++EL++K+D
Sbjct: 359  EKQQHIEQLLAERDLE----RAEVAKATS---HVGEIEQELALARDGHDQHVLELEAKMD 411

Query: 1185 SELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQT 1244
               + +E    EK+         ++  LE++++K+   Q +  E+ I K + E    +  
Sbjct: 412  QLRTMVEAADREKV--------ELLNQLEEEKRKVEDLQFRVEEESITKGDLEV-ATVSE 462

Query: 1245 ALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSL--VAELQEKL------- 1295
              +  +LE+++  +  +++V  L  ++  +          S L  ++ LQEKL       
Sbjct: 463  KSRIMELEKDLALR--VQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDH 520

Query: 1296 QEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKEN--IINDLSDK 1353
            Q E     E    +E+   +E++ + T+     + N +     E   KEN  +I     K
Sbjct: 521  QREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSK 580

Query: 1354 LKSTM-QQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLR---------SSSFVPSPYV 1403
            L++ +   Q+  ++L  S S+       E  +L+ ++ K+R           +   S   
Sbjct: 581  LETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERA 640

Query: 1404 ATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLE 1463
            A A E+    A  +    ++     A   ++D A +  ++ +++ ++ L E + ++  LE
Sbjct: 641  AHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELE 700

Query: 1464 RTLQLKEEENKRLNQRLMSQ 1483
              LQ K  E  ++     SQ
Sbjct: 701  -VLQAKCNEQTKVIDNFTSQ 719



 Score = 32.7 bits (73), Expect = 2.9
 Identities = 40/148 (27%), Positives = 63/148 (42%), Gaps = 22/148 (14%)

Query: 1353 KLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGA 1412
            K+  T   QE  K+  + + +    LL E+     EV+K  S        +A A + +  
Sbjct: 346  KISGTTALQEALKEKQQHIEQ----LLAERDLERAEVAKATSHVGEIEQELALARDGHDQ 401

Query: 1413 CAPELPGESD--RSAVETADEGRVD--SAMETSMMSVQENIHMLSEE------------- 1455
               EL  + D  R+ VE AD  +V+  + +E     V++    + EE             
Sbjct: 402  HVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVS 461

Query: 1456 -KQRIMLLERTLQLKEEENKRLNQRLMS 1482
             K RIM LE+ L L+ +E   L +RL S
Sbjct: 462  EKSRIMELEKDLALRVQEVAELRRRLES 489


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  113 bits (283), Expect = 1e-24
 Identities = 162/762 (21%), Positives = 330/762 (43%), Gaps = 87/762 (11%)

Query: 797  QLERCRVVAQDSHFSIQTIKEDLCHFRTFVQK----EQCDFSNSLKCTAVEIRNIIEKVK 852
            +LE+    AQ +  + + +K ++      ++K    E+      L     E+ ++++K  
Sbjct: 415  ELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSS 474

Query: 853  CSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENEN-KIKKLKGELVCLEEVLQNKDN 911
                  L++ H+KEL   + E   KL    +E +E     ++K + E +   ++ Q K+ 
Sbjct: 475  EEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYL---KISQEKEQ 531

Query: 912  EFALVKHE----KEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKK--- 964
            + +L   E    K+A++    E + KL +++    +    I EL+ S E  L++ K    
Sbjct: 532  QESLALEELELQKKAIL---TESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSK 588

Query: 965  ---LHVENDE----KLQLLRAELQSLEQSHLKELEDTLQVRHIQ--------EFEKVMTD 1009
               +H+E ++    K   +  E    E   LK  +D L    +Q        E EK+   
Sbjct: 589  DLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK 648

Query: 1010 HRVSLEELKKENQQI----INQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELA 1065
                 E L K+ + I    I ++ E   E +  K+ +L+ L  ++S++   R KLE EL+
Sbjct: 649  CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708

Query: 1066 LKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAEL 1125
            + + +TD++K  LE    +QK   +  ++   +     I +  + ++D     ++ L E 
Sbjct: 709  VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKE- 767

Query: 1126 RTLMTIEKDQCISEL---ISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSK 1182
            R     E    +  L   I R E E     A+L+   S  +   E  K  +EQ+ +LQ K
Sbjct: 768  RDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK 827

Query: 1183 ----------LDSELSALERQKDEKITQQEE---KYEAIIQNLEKDRQKL---VSSQEQD 1226
                      L  +++ +E QK +  T+ +    + + ++Q LEK   ++   V S  Q 
Sbjct: 828  LLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQV 887

Query: 1227 REQLIQKLNCEKDEAIQTALKEFKL---EREVVEKE---LLEKVKHLENQI-AKSPAIDS 1279
             E  ++  N E+++  Q  +++  +    RE  +KE   L +K+   E+ I   +   ++
Sbjct: 888  YESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYET 947

Query: 1280 TRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTRE 1339
               +    + ++++K +E +    ++L +QE +  +E++N    L ++++  FN  +   
Sbjct: 948  KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALEL-SQKEKQFNAKMLEM 1006

Query: 1340 KMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEE-----KKKLEEEVSKLRS 1394
                   I+D   +L++  ++Q      IESL+E   R L +     +KKL ++  +L+ 
Sbjct: 1007 AQANSAGISDAVSRLETNQKEQ------IESLTEVHRRELNDVISIWEKKLNQQAEELQE 1060

Query: 1395 SSFV----PSPYVATAPE---LYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQE 1447
               +        VA   +   L+G    E+  E      E   +    + ++  +     
Sbjct: 1061 IHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSA 1120

Query: 1448 NIHMLSEE----KQRIMLLERTLQLKEEENKRLNQRLMSQSM 1485
            +++ L+++    K  +  LE  L    +EN  L ++L+   M
Sbjct: 1121 HVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKM 1162



 Score =  113 bits (282), Expect = 2e-24
 Identities = 148/663 (22%), Positives = 304/663 (45%), Gaps = 100/663 (15%)

Query: 806  QDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLK-EKHQ 864
            +D     +T +  +    + ++K   +  N  K  AV +    EK K + EIT+  EKH+
Sbjct: 556  RDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLE--AEKNKHNKEITVMVEKHK 613

Query: 865  KELLSLKNEYEGKLDGLIKETEEN-ENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAV 923
             EL SLK++ +      ++  ++  + +++KL+ +    +E L  KD E     H +E  
Sbjct: 614  TELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLL-KDKEIIFQAHIEE-- 670

Query: 924  ICLQNEKDQKLLEMENI-MHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQS 982
                NEK  + L+++   + S + E+ E+ ++R  + E+L  L  + D+  Q L A++  
Sbjct: 671  ---MNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDE 727

Query: 983  LEQSHLKELEDTLQVRH--IQEFEKVMTDHRVSLEELKKENQQIINQ-----------IQ 1029
             +  H ++++  ++     IQ  EK + D    LE L KE  + + +           I+
Sbjct: 728  QKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIK 787

Query: 1030 ESHAEIIQEK--------------------EKQLQELKLKVSDLSDTRCKLEVELALKEA 1069
             S  E+ Q                      E+QL +L+ K+ DL   R  L  ++A  EA
Sbjct: 788  RSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEA 847

Query: 1070 ETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQ----KIQDNNENY----QVG 1121
            +  ++   L+  + Q ++ ++ L +Q +E +  ++  L Q    K++D N+      Q+ 
Sbjct: 848  QKKDVCTELDAHKIQVQDLMQQLEKQNSE-MEQKVKSLTQVYESKLEDGNKEQEQTKQIL 906

Query: 1122 LAELRTLMTIEKDQ-----CISELISRHEEESNILKAELN--------KVTSLHNQAFEI 1168
            + +   ++ + + Q      +++ +S  E+  +IL  E          K+  +  +A E+
Sbjct: 907  VEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEM 966

Query: 1169 EKNLKEQIIELQSKLDSEL--SALERQKDEKITQQE--EKYEAIIQNLEKDRQKLVSSQE 1224
            ++ LK+++++ ++KL  EL  +ALE  + EK    +  E  +A    +     +L ++Q+
Sbjct: 967  QETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQK 1026

Query: 1225 QDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDS 1284
            +  E L +    E ++ I  ++ E KL ++  E + + +++  E +              
Sbjct: 1027 EQIESLTEVHRRELNDVI--SIWEKKLNQQAEELQEIHEIQLQEKE-------------- 1070

Query: 1285 SSLVAELQEKL------QEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVL-- 1336
               VAEL++K+      +EE  K +  L+E+  +++  +  ++  L  ++  + N++   
Sbjct: 1071 -QEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL-KQKSAHVNSLAQD 1128

Query: 1337 -TREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKL---EEEVSKL 1392
             T+ K   E +  DL+  LK     QE+  +L     ED+ ++ E   KL   +EE   L
Sbjct: 1129 ETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSL 1188

Query: 1393 RSS 1395
            +SS
Sbjct: 1189 KSS 1191



 Score =  105 bits (261), Expect = 5e-22
 Identities = 134/667 (20%), Positives = 305/667 (45%), Gaps = 68/667 (10%)

Query: 850  KVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNK 909
            K +C+L  + KE  Q++L     E E K+  L     E    I +L+     +E++ Q+K
Sbjct: 306  KEQCTLLTSEKEALQEQLDERLQELE-KIKDL--HMAEKTKLITQLRDAKNLIEQLEQDK 362

Query: 910  DNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQ-SREIVLEDLKKLHVE 968
                A  K +    + ++ E+  +L      M +Q  E++E K+ S     E+L+K  + 
Sbjct: 363  GMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKA-LS 421

Query: 969  NDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQI 1028
              +K +  R +L++     +K +E T +   I   +++    +  ++ +KK +++ I ++
Sbjct: 422  TAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL 481

Query: 1029 QESHAEIIQEKEKQL-QELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKE 1087
            Q+ H + +  KE++L ++L+ +  +  +     ++++AL++++++ +KI   + + QQ+ 
Sbjct: 482  QKLHEKELARKEQELTKKLQTREREFQE-----QMKVALEKSQSEYLKI--SQEKEQQES 534

Query: 1088 TLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEE 1147
                 LE + + + TE     + +Q   E Y+  + EL +  ++EK       +  ++ +
Sbjct: 535  LALEELELQKKAILTESENKLRDLQQEAETYRTRILELES--SLEKS------LQENKNQ 586

Query: 1148 SNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEA 1207
            S  L   L    + HN          ++I  +  K  +EL +L+ Q+D   T   EK + 
Sbjct: 587  SKDLAVHLEAEKNKHN----------KEITVMVEKHKTELESLKHQQDALWT---EKLQV 633

Query: 1208 IIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFK---LEREVVEKELLEKV 1264
            + Q  + + +KL    EQ++E L++    +K+   Q  ++E     LE+  V++  LE +
Sbjct: 634  LKQQYQTEMEKLREKCEQEKETLLK----DKEIIFQAHIEEMNEKTLEKLDVKQTELESL 689

Query: 1265 KHLENQIAKS-----PAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQN 1319
                +++ K+       +   +  +  +  EL+ K+ E+K    +Q++   K     +Q 
Sbjct: 690  SSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQ- 748

Query: 1320 VRTSLIAEQQTNFNTVLTREKMRK--------ENIINDLSDKLKSTMQQQERDKDLI--- 1368
             RT    + Q N   +L +E+ +         EN+  D+  + +  +QQ     D+    
Sbjct: 749  -RTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIK-RSEGELQQASAKLDVFQSY 806

Query: 1369 ESLSEDRARLLEEK-KKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVE 1427
            +S + ++ +  EE+  +L++++  L +   + +  VA           EL     +    
Sbjct: 807  QSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDL 866

Query: 1428 TADEGRVDSAMETSMMSVQ-------ENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRL 1480
                 + +S ME  + S+        E+ +   E+ ++I++ +  + L+  E ++    +
Sbjct: 867  MQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEI 926

Query: 1481 MSQSMSS 1487
            ++Q +S+
Sbjct: 927  LTQKLSA 933



 Score =  100 bits (250), Expect = 9e-21
 Identities = 116/575 (20%), Positives = 267/575 (46%), Gaps = 41/575 (7%)

Query: 793  SLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVK 852
            S+  +LE  +   +  + S+++ +E+L      ++ E       LK  A +    I+K  
Sbjct: 1596 SMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL 1655

Query: 853  CSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNE 912
             S     +E+++K   S  +E   KL    +E    E K+K ++        V ++  N 
Sbjct: 1656 LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNV 1715

Query: 913  FALVKHEK-EAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDE 971
             A  + E+ ++  C+Q   ++K+  ++  +  +   ++ + Q +E  +    ++  +  E
Sbjct: 1716 AAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQE 1775

Query: 972  KLQLLRAELQSLEQSHLKELEDTLQVRHIQEF--EKVMTDHRVSLEELKKENQQIINQIQ 1029
            +L         LE +  K+ ED   + H+QE   EK      +  + ++KE  +   Q +
Sbjct: 1776 RLI-------KLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAK 1828

Query: 1030 ESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETL 1089
            ++   +  + +K LQE +L    L     +L+  L +++ E   +++   E    + E L
Sbjct: 1829 QNLENVFDDVQKTLQEKELTCQILEQKIKELDSCL-VRQKEVHRVEM---EELTSKYEKL 1884

Query: 1090 KSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEE-ES 1148
            ++L + +  N  TE+  L +  ++ ++++ V            + + +S + ++H + E 
Sbjct: 1885 QALQQMDGRNKPTEL--LEENTEEKSKSHLV------------QPKLLSNMEAQHNDLEF 1930

Query: 1149 NILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEE----K 1204
             +  AE  K   L  +   ++K+L+    E Q +L+      +++++EKI Q++E    K
Sbjct: 1931 KLAGAEREK-QKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELK 1989

Query: 1205 YEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKV 1264
            + + ++ L ++    ++ +EQ+ E  I++   +  E     L+  + E   + K++ EK 
Sbjct: 1990 HNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKD 2049

Query: 1265 KHLENQIAK-SPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTS 1323
              L+    +    +D+   + ++ V +LQ +L+E + K+ ++LE++E   N+   NV   
Sbjct: 2050 DDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGND---NVTIM 2106

Query: 1324 LIAEQQTNFNTVLTREKMRKENI---INDLSDKLK 1355
             +  Q     T+++  K++++     I++L D+LK
Sbjct: 2107 ELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLK 2141



 Score =  100 bits (248), Expect = 1e-20
 Identities = 155/745 (20%), Positives = 331/745 (44%), Gaps = 100/745 (13%)

Query: 709  NIEQTIHQVSLDLDSLAESPESDFMSAVNE--FVIEENLSSPNPISDPQSPEMMVESLYS 766
            + +Q  HQ+  + ++  +S ++D  S V E   + +E  +     S+ +S    ++   S
Sbjct: 1291 SFQQATHQLE-EKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELS 1349

Query: 767  SVINAIDSRRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFV 826
              INA+   + +      KE   + +SL+ QL    V  Q+S  S+   +  +   R   
Sbjct: 1350 ENINAVTLMKEEL-----KEKKVEISSLSKQLTDLNVQLQNS-ISLSEKEAAISSLRKQY 1403

Query: 827  QKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETE 886
             +E+C+  + ++               S ++    K +   L   +++  K     K+ +
Sbjct: 1404 DEEKCELLDQVQ-------------DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQ 1450

Query: 887  ----ENENKIKKLKGELVCLEEVLQNKDNEFALVKHE----KEAVICLQNEKDQKLLEME 938
                +++N +K+L+ +L    +    KD +  L+K E     +   CL+ E +    +ME
Sbjct: 1451 SRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKME 1510

Query: 939  NIMHSQNCEIKELKQSREIVLEDLKKLHV-ENDEKLQLLRAELQSLEQSHLKELEDTLQV 997
                +   E+K  + +R + LED    H+ +   +++ L   L++  Q   K++E    V
Sbjct: 1511 KKESNLETELKS-QTARIMELED----HITQKTIEIESLNEVLKNYNQQ--KDIEHKELV 1563

Query: 998  RHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVS----DL 1053
            + +Q F+++  +    ++E +++   + NQ+    AE+ + K+K+L+ + L V     +L
Sbjct: 1564 QKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAEL-ETKKKELEHVNLSVKSKEEEL 1622

Query: 1054 SDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLR----TEISKLNQ 1109
                 +LE E A K AE   +K   E+  A  K+ L S +E++ E  +    + +S+LN 
Sbjct: 1623 KALEDRLESESAAKLAE---LKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNT 1679

Query: 1110 KIQDNNENYQVGLAELRTLMTIEKDQCISELISRH------EEESN----ILKAELNKVT 1159
            K+Q+      +   +L+++ + + +  I    +++      +EE++    + K    K++
Sbjct: 1680 KLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKIS 1739

Query: 1160 SLHNQAFEIEKNL------KEQII----ELQSKLDSELSALERQK-------------DE 1196
             L     E EK L      KE+ +    E++ +    L  LE  +              E
Sbjct: 1740 VLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQE 1799

Query: 1197 KITQQEEKYEAII-QNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREV 1255
            ++ ++ +KY  I+ Q++EK+  K     +Q+ E +         + +Q  L+E +L  ++
Sbjct: 1800 ELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVF--------DDVQKTLQEKELTCQI 1851

Query: 1256 VEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEE--KAKFLEQLEE--QEK 1311
            +E    +K+K L++ + +   +     +  +   E  + LQ+   + K  E LEE  +EK
Sbjct: 1852 LE----QKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEK 1907

Query: 1312 RKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESL 1371
             K+  +Q    S +  Q  +    L   +  K+ +  ++    K     ++  +  +E L
Sbjct: 1908 SKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEIL 1967

Query: 1372 SEDRARLLEEKKKLEEEVSKLRSSS 1396
             ++  +  EEK K E+E  +L+ +S
Sbjct: 1968 KKEYDQEREEKIKQEQEDLELKHNS 1992



 Score = 98.2 bits (243), Expect = 6e-20
 Identities = 183/887 (20%), Positives = 371/887 (41%), Gaps = 157/887 (17%)

Query: 785  KEDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTA--- 841
            +E     T+LN   E+ +   + +H  + ++ +D    +  ++K + D + SLK      
Sbjct: 1099 EEGVKQDTTLNELQEQLK--QKSAH--VNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQ 1154

Query: 842  ---VEIRNIIEKVKCSL-EITLKEKH-QKELLSLKNEYEGKLDGLIKETEENENKIKKLK 896
               VE++ + E+ K  + E+T K K   +E  SLK+ +E       K  E+   + KKL 
Sbjct: 1155 EQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSN----KSLEDKSLEFKKLS 1210

Query: 897  GEL-----VCL---EEVLQNKDNEFALVKHEK-EAVICLQNEKDQKLLEMENIMHSQNCE 947
             EL     +C    E +L+ K NE   +   K  A++   +    +  +++  +  + C 
Sbjct: 1211 EELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCT 1270

Query: 948  IKELKQSREIVLEDLKKLHV----------ENDEKLQLLRAELQSL-EQSHLKELEDTLQ 996
            + EL+     + E+   L++          E + +++ ++A+++SL  +    + E   Q
Sbjct: 1271 VSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQ 1330

Query: 997  VRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDT 1056
             +   E E  +T       +LKKE  + IN +     E+ +EK+ ++  L  +++DL+  
Sbjct: 1331 QQAASEKESCIT-------QLKKELSENINAVTLMKEEL-KEKKVEISSLSKQLTDLN-V 1381

Query: 1057 RCKLEVELALKEAETDEIKILLEESRAQ---------------QKETLKSLLEQETENLR 1101
            + +  + L+ KEA    ++   +E + +                KE + +L  ++ ++  
Sbjct: 1382 QLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISAL--EQVDDWS 1439

Query: 1102 TEISKLNQKIQDNNENYQVGLAELRTLMTI------EKDQCISELISR------------ 1143
             + S+  +K Q     +Q  + EL+  + +      EKD+ I+ L               
Sbjct: 1440 NKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLK 1499

Query: 1144 ---HEEESNILKAELNKVTSLHNQA---FEIEKNLKEQIIELQSKLDSELSALERQKD-- 1195
                +++S + K E N  T L +Q     E+E ++ ++ IE++S L+  L    +QKD  
Sbjct: 1500 GEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIES-LNEVLKNYNQQKDIE 1558

Query: 1196 --------------------------EKITQQEEKYEAIIQNLEKDRQKL------VSSQ 1223
                                      EKI   E +  ++   LE  +++L      V S+
Sbjct: 1559 HKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSK 1618

Query: 1224 EQDREQLIQKLNCEKDEAIQTALKEFKLEREV--VEKELLEKVKHLENQIAKSPAIDSTR 1281
            E++ + L  +L  E + A + A  + K E+++  ++K+LL +++  E Q  K      T 
Sbjct: 1619 EEELKALEDRL--ESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKG-----TE 1671

Query: 1282 GDSSSLVAELQEK-----LQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVL 1336
               S L  +LQE+     + EEK K +E  + +        +NV      E+  +   V 
Sbjct: 1672 SHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ 1731

Query: 1337 TREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSS 1396
               + +   +  +L++K K   +  +  ++ + S  E R +  E   KLE   +K     
Sbjct: 1732 KTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQ 1791

Query: 1397 FVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEK 1456
                        + G    EL  ++ + ++  A    V+     + +  ++N+  + ++ 
Sbjct: 1792 -----------SMIGHLQEELEEKNKKYSLIVAQ--HVEKEGGKNNIQAKQNLENVFDDV 1838

Query: 1457 QR-IMLLERTLQLKEEENKRLNQRLMSQ------SMSSVSSRHSEKIAIRDFQVGDLVLI 1509
            Q+ +   E T Q+ E++ K L+  L+ Q       M  ++S++ +  A++     +    
Sbjct: 1839 QKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTE 1898

Query: 1510 ILDER-HDNYVLFTVSPTLYFLHSESLPALDLKPASGASRRPWVLGK 1555
            +L+E   +      V P L          L+ K A GA R    LGK
Sbjct: 1899 LLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLA-GAEREKQKLGK 1944



 Score = 87.8 bits (216), Expect = 8e-17
 Identities = 143/625 (22%), Positives = 260/625 (41%), Gaps = 117/625 (18%)

Query: 826  VQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKET 885
            V+ ++ D    L    +++++++++    LE    E  QK + SL   YE KL+   KE 
Sbjct: 845  VEAQKKDVCTELDAHKIQVQDLMQQ----LEKQNSEMEQK-VKSLTQVYESKLEDGNKEQ 899

Query: 886  E-------ENENKIKKL----KGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKL 934
            E       E EN I ++    K E+  L + L  K++   ++  E E     Q +K +K+
Sbjct: 900  EQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKV 959

Query: 935  LEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDT 994
             +    M  Q    K+L      + ++L+   +E  +K +   A++  + Q++   + D 
Sbjct: 960  KQKAKEM--QETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDA 1017

Query: 995  ---LQVRHIQEFEKVMTDHRVSLEEL-----KKENQQIINQIQESHAEIIQEKEKQLQEL 1046
               L+    ++ E +   HR  L ++     KK NQQ   ++QE H   +QEKE+++ EL
Sbjct: 1018 VSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQA-EELQEIHEIQLQEKEQEVAEL 1076

Query: 1047 KLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISK 1106
            K K+       C+       KE    EI  L EE   +Q  TL  L EQ    L+ + + 
Sbjct: 1077 KQKILLFG---CE-------KEEMNKEITWLKEEG-VKQDTTLNELQEQ----LKQKSAH 1121

Query: 1107 LNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAF 1166
            +N   QD  +                                  LKA L K+    N++ 
Sbjct: 1122 VNSLAQDETK----------------------------------LKAHLEKLEVDLNKSL 1147

Query: 1167 EIEKNLKEQIIELQSKLD------SELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLV 1220
            +    L+EQ++EL+   +      SEL++  +  DE+    +  +E   ++LE    +  
Sbjct: 1148 KENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFK 1207

Query: 1221 SSQEQDREQLIQKLNCEKDEA-IQTALKEFKLEREVVEKELLEKVKHLENQIAK-SPAID 1278
               E+   QL   + C+K EA ++    E           +L ++ H +++  K   A+ 
Sbjct: 1208 KLSEELAIQL--DICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALL 1265

Query: 1279 STRGDSSSLVAELQEKLQEEK---------AKFLEQLEEQEKRKNEEMQNVRTSLIAEQQ 1329
                  S L A+L++  +E+             LE+ E Q K    +++++ T   A Q+
Sbjct: 1266 IKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQK 1325

Query: 1330 TNFN------------TVLTREKMRKENIINDLSDKLK------STMQQQERDKDL---- 1367
               N            T L +E     N +  + ++LK      S++ +Q  D ++    
Sbjct: 1326 EGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQN 1385

Query: 1368 IESLSEDRARLLEEKKKLEEEVSKL 1392
              SLSE  A +   +K+ +EE  +L
Sbjct: 1386 SISLSEKEAAISSLRKQYDEEKCEL 1410



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 116/567 (20%), Positives = 254/567 (44%), Gaps = 85/567 (14%)

Query: 883  KETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMH 942
            +E+ + ++  +KL+  +  +E + ++   E       KE+++   + +    L++++   
Sbjct: 53   RESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTA 112

Query: 943  SQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLK--ELEDTLQV--R 998
            S +    ++    E ++ +   L+ E  + +Q LR   +SL     K  EL    Q+  R
Sbjct: 113  SFDPP-SDMDSEAEDLVGNSDSLNKE--QLIQRLRRMERSLSSYRGKYSELVTAYQMLQR 169

Query: 999  HIQEFEKVMTDHRVS----LEELKKE---NQQIINQIQESHAEIIQEKEKQLQELKLKVS 1051
              ++ + +++  +      + EL++E   +QQ    +QE     ++EK++ +  L+ +VS
Sbjct: 170  EKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVS 229

Query: 1052 DL----------------------------------SDTRCKLEVELALKEAETDEIKIL 1077
             L                                  SD    +E   ++K  ET + ++ 
Sbjct: 230  LLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVK 289

Query: 1078 LEESRAQQ-KETLKS------LLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMT 1130
             +E+  ++ KET++S      LL  E E L+    +L++++Q+  +   + +AE   L+T
Sbjct: 290  RQENLLKRCKETIQSHKEQCTLLTSEKEALQ---EQLDERLQELEKIKDLHMAEKTKLIT 346

Query: 1131 IEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSAL 1190
              +D     LI + E++  ++ AE  +      Q  E  +  +E+I +L+S+    +  +
Sbjct: 347  QLRD--AKNLIEQLEQDKGMVIAETKR------QMHETLEMKEEEIAQLRSR----IKQM 394

Query: 1191 ERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFK 1250
              Q +E   Q+E+   A  + LEK       S  Q  E+  +KL  E DE I+T  K  +
Sbjct: 395  TTQGEELREQKEKSERAAFEELEK-----ALSTAQKTEEARRKLKAEMDEQIKTIEKTSE 449

Query: 1251 LEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQE 1310
             ER  +++EL            K   +D  +  S   +A+LQ+  ++E A+  ++L ++ 
Sbjct: 450  EERISLQQELSR---------VKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKL 500

Query: 1311 KRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERD-KDLIE 1369
            + +  E Q      + + Q+ +  +   ++ ++   + +L  + K+ + + E   +DL +
Sbjct: 501  QTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQ 560

Query: 1370 SLSEDRARLLEEKKKLEEEVSKLRSSS 1396
                 R R+LE +  LE+ + + ++ S
Sbjct: 561  EAETYRTRILELESSLEKSLQENKNQS 587



 Score = 68.6 bits (166), Expect = 5e-11
 Identities = 77/314 (24%), Positives = 141/314 (44%), Gaps = 51/314 (16%)

Query: 860  KEKHQKELLSLKNEYEG-----KLDGLIKETEE-NENKIKKLKGELVCLEEVLQNKDNEF 913
            KE H+ E+  L ++YE      ++DG  K TE   EN  +K K  LV   ++L N + + 
Sbjct: 1867 KEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLV-QPKLLSNMEAQ- 1924

Query: 914  ALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKL 973
                          N+ + KL   E        EI  L++       DL+ L  E+ ++L
Sbjct: 1925 -------------HNDLEFKLAGAEREKQKLGKEIVRLQK-------DLRMLRKEHQQEL 1964

Query: 974  QLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSL----EELKKENQQIINQIQ 1029
            ++L+ E     +  +K+ ++ L+++H    +++M +    L    +EL+   ++ IN+ Q
Sbjct: 1965 EILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQ 2024

Query: 1030 ESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETL 1089
            E  AE+++  +++  +L  K+++  D       +L       +EI    EE    +   L
Sbjct: 2025 EVEAELLESHQEETNQLLKKIAEKDD-------DLKRTAKRYEEILDAREEEMTAKVRDL 2077

Query: 1090 KSLLEQETENLRTEISKLNQKIQDNNEN-----YQVGLAELRTLMTIE--KDQCISELIS 1142
            ++ LE+  +  +    KL Q+    N+N      Q  LA+  TL++    K+Q   E I 
Sbjct: 2078 QTQLEELQKKYQ---QKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQI- 2133

Query: 1143 RHEEESNILKAELN 1156
             H  E  + K E N
Sbjct: 2134 -HNLEDRLKKYEKN 2146



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 92/422 (21%), Positives = 176/422 (41%), Gaps = 84/422 (19%)

Query: 1093 LEQETENLRTEISKLNQ--------KIQDNNENYQVGLAELRTL--MTIEKDQCISELIS 1142
            ++ E E+L      LN+        +++ +  +Y+   +EL T   M   + + +  ++S
Sbjct: 120  MDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILS 179

Query: 1143 RHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQE 1202
            + +++S    AEL +   +  QA   +K+L+E           E  A   +KD+ I+  +
Sbjct: 180  QSQDKSLRRIAELREELQMDQQA---KKHLQE-----------EFDASLEEKDQYISVLQ 225

Query: 1203 EKYEAIIQNLEK-----DRQKLVSSQEQDREQLIQKLNCEKD--EAIQTALKEFKLEREV 1255
             +   + Q L       D  K +   E   E   ++ N E D    ++       LE   
Sbjct: 226  TQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLET-- 283

Query: 1256 VEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNE 1315
                L ++VK  EN + +      +  +  +L+   +E LQE+     E+L+E EK K+ 
Sbjct: 284  ----LQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQ---LDERLQELEKIKDL 336

Query: 1316 EMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDR 1375
             M                         K  +I  L D  K+ ++Q E+DK ++  ++E +
Sbjct: 337  HM-----------------------AEKTKLITQLRD-AKNLIEQLEQDKGMV--IAETK 370

Query: 1376 ARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVD 1435
             ++ E  +  EEE+++LRS                G    E   +S+R+A E      ++
Sbjct: 371  RQMHETLEMKEEEIAQLRSR--------IKQMTTQGEELREQKEKSERAAFE-----ELE 417

Query: 1436 SAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRL--MSQSMSSVSSRHS 1493
             A+ T+  + +    + +E  ++I  +E+T    EEE   L Q L  + Q +  V  + S
Sbjct: 418  KALSTAQKTEEARRKLKAEMDEQIKTIEKT---SEEERISLQQELSRVKQEVVDVMKKSS 474

Query: 1494 EK 1495
            E+
Sbjct: 475  EE 476


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  113 bits (282), Expect = 2e-24
 Identities = 156/703 (22%), Positives = 329/703 (46%), Gaps = 89/703 (12%)

Query: 849  EKVKCSLEITLKEKH-QKELLSLK---NEYEGKLDGLIKETEENENKIKKLKGELVCLEE 904
            E+ + + E+  K+++ + +  SLK   ++ E  L  + KE    ENK+K L  E+  LEE
Sbjct: 932  EEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEE 991

Query: 905  VLQNKDNE-FALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLK 963
             +     E  +L +  ++ +  LQ E+D+      N +   N ++++     E  LE  K
Sbjct: 992  NISKLTKEKKSLQEAHQQTLDDLQVEEDK-----VNGLIKINAKLEQQTDDLEGSLEQEK 1046

Query: 964  KLHVENDEKLQLLRAELQSLEQSHL------KELEDTLQVR--HIQEFEKVMTDHRVSLE 1015
            KL  + +   + L  +L+  ++S +      +++E+ L+ +   + + +  + D +V   
Sbjct: 1047 KLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSL 1106

Query: 1016 ELKKENQQIINQIQESHAEIIQEK------EKQLQELKLKVSDLSD--------TRCKLE 1061
            + +K+ +++  +I+E   EI  E       EKQ  +L  ++ ++S+        T  ++E
Sbjct: 1107 QFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIE 1166

Query: 1062 VELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVG 1121
            +    +EAE  +++  LEE+  Q + T  +L +++ ++    +++L ++I DN +  +  
Sbjct: 1167 MN-KKREAEFQKMRRDLEEATLQHEATAATLRKKQADS----VAELGEQI-DNLQRVKQK 1220

Query: 1122 LAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQS 1181
            L + ++ + +E D   S + +  + +SNI +       ++ +Q  EI K   EQ  +L  
Sbjct: 1221 LEKEKSELKMEIDDMASNIEALSKSKSNIERT----CRTVEDQFSEI-KAKDEQQTQLIH 1275

Query: 1182 KLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEK--D 1239
             L+ + + L+ Q  E   + EEK E++I  L K +Q L    E+ + Q+ ++   +    
Sbjct: 1276 DLNMQKARLQTQNGELSHRVEEK-ESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMA 1334

Query: 1240 EAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEK 1299
             A+Q++  +  L RE  E+E   K + L+  ++K          ++S VA+ + K + + 
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKAE-LQRALSK----------ANSEVAQWRTKYETDA 1383

Query: 1300 AKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLK---- 1355
             +  E+LEE +K+  + +Q    +   E   +    L + K R +  + DL   L+    
Sbjct: 1384 IQRTEELEEAKKKLAQRLQEAEEN--TETANSKCASLEKTKQRLQGEVEDLMRDLERSHT 1441

Query: 1356 --STMQQQERDKDLI-----ESLSEDRARL---LEEKKKLEEEVSKLRSSSFVPSPYVAT 1405
              +T+ +++R+ D +     + L E +A L    +E + L  E+ K+R++      Y   
Sbjct: 1442 ACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNA------YEEV 1495

Query: 1406 APELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQ--RIMLLE 1463
              +L       L  E+     E +D     +    ++   ++   ++ +EK   ++ L E
Sbjct: 1496 VDQL-----ETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEE 1550

Query: 1464 RTLQLKEEENKRLNQRLMSQSMSSVSSRHSEKIAIRDFQVGDL 1506
                L+ EE+K L  +L    +S V S    K+  +D ++  L
Sbjct: 1551 VEGSLEHEESKILRVQL---ELSQVKSELDRKVIEKDEEIEQL 1590



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 127/575 (22%), Positives = 255/575 (44%), Gaps = 88/575 (15%)

Query: 842  VEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVC 901
            ++ +N  EK+  S+++   ++ Q    + K  ++  L GL++E  + +        + VC
Sbjct: 740  IDSKNASEKLLNSIDV---DREQFRFGNTKVFFKAGLLGLLEEMRDEKLVTLMTSTQAVC 796

Query: 902  LEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMH----SQNCEIKELKQSREI 957
               +++    EF  +   ++++ C+Q      +    N+ H    +   +IK L +S E 
Sbjct: 797  RGYLMRV---EFKKMMERRDSIFCIQ----YNIRSFMNVKHWPWMNLFFKIKPLLKSAEA 849

Query: 958  VLE--DLKKLHVENDEKLQLLRAELQSLEQSHLKELEDT--LQVRHIQEFEKVMTDH--- 1010
              E   +K+      E+L    A  + LE+  +  L++   LQ++   E E +M      
Sbjct: 850  EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERC 909

Query: 1011 ------RVSLEELKKENQQIINQIQESHAEIIQEK---EKQLQELKLKVSDLSDTRCKLE 1061
                  ++ LE   KE  + + + +E ++E++ +K   E +   LK  + DL  T  K+E
Sbjct: 910  EGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVE 969

Query: 1062 VELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVG 1121
             E   K A  +++K L EE  A                L   ISKL ++ +   E +Q  
Sbjct: 970  KE---KHATENKVKNLSEEMTA----------------LEENISKLTKEKKSLQEAHQQT 1010

Query: 1122 LAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQS 1181
            L +L+    +E+D+ ++ LI         + A+L + T     + E EK L+  +   + 
Sbjct: 1011 LDDLQ----VEEDK-VNGLIK--------INAKLEQQTDDLEGSLEQEKKLRADLERAKR 1057

Query: 1182 KLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKL---VSSQEQDREQLIQKLNCEK 1238
            KL+ +L         K++Q+       I +LE D+Q++   +  +E +  QL  K++ E+
Sbjct: 1058 KLEGDL---------KMSQES------IMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQ 1102

Query: 1239 DEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEE 1298
              ++Q   K  +L+  + E E     + +E +      I+  R D +  + E+ E+L+E 
Sbjct: 1103 VHSLQFQKKIKELQARIEELE-----EEIEAEHTLRAKIEKQRSDLARELEEISERLEEA 1157

Query: 1299 KAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENI--INDLSDKLKS 1356
                  Q+E  +KR+  E Q +R  L      +  T  T  K + +++  + +  D L+ 
Sbjct: 1158 SGATSAQIEMNKKRE-AEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQR 1216

Query: 1357 TMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSK 1391
              Q+ E++K  ++   +D A  +E   K +  + +
Sbjct: 1217 VKQKLEKEKSELKMEIDDMASNIEALSKSKSNIER 1251



 Score = 84.7 bits (208), Expect = 6e-16
 Identities = 141/648 (21%), Positives = 283/648 (43%), Gaps = 95/648 (14%)

Query: 811  SIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCS----LEITLKEKHQKE 866
            ++Q +K+ L   ++ ++ E  D +++++  +    NI    +       EI  K++ Q +
Sbjct: 1213 NLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQ 1272

Query: 867  LLSLKNEYEGKLDG----LIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEA 922
            L+   N  + +L      L    EE E+ I +L      L + L+    +   ++ E +A
Sbjct: 1273 LIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQ---MEEETKA 1329

Query: 923  VICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQS 982
                   K+     +++  H  +   ++ ++ +E   E  + L   N E  Q  R + ++
Sbjct: 1330 -------KNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQW-RTKYET 1381

Query: 983  LEQSHLKELEDTLQ--VRHIQEFEK---VMTDHRVSLEELKK----ENQQIINQIQESHA 1033
                  +ELE+  +   + +QE E+          SLE+ K+    E + ++  ++ SH 
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHT 1441

Query: 1034 EIIQEKEKQ------LQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKE 1087
                  +KQ      L E K K+ +      + E+E A KE+ +   ++    +  ++  
Sbjct: 1442 ACATLDKKQRNFDKVLAEWKQKLDE-----SQAELEAAQKESRSLSTELFKMRNAYEEVV 1496

Query: 1088 TLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKD--QCISELI--SR 1143
                 L +E +NL+ EIS L ++I +  +N Q    + + L+  EK   Q   E +  S 
Sbjct: 1497 DQLETLRRENKNLQEEISDLTEQIAETGKNLQEA-EKTKKLVEQEKSDLQVALEEVEGSL 1555

Query: 1144 HEEESNILKAEL----------NKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSA---- 1189
              EES IL+ +L           KV     +  ++++N +     LQS LD+E+ +    
Sbjct: 1556 EHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDA 1615

Query: 1190 --LERQKDEKITQQE-------------EKYEAIIQNLEKDRQ----KLVSSQEQDREQL 1230
              L+++ +  + + E             +K+   +Q   KD Q      + S E  +EQL
Sbjct: 1616 LRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQL 1675

Query: 1231 --IQKLN---CEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTR---- 1281
              +++ N    E+ E ++ AL++ +  R + E+ELL+    ++   +++ ++ +T+    
Sbjct: 1676 AIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLE 1735

Query: 1282 GDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKM 1341
             D +   AE++  +QE +       EE+ K+   +   +   L  EQ T+ +  L R K 
Sbjct: 1736 ADIAQCQAEVENSIQESR-----NAEEKAKKAITDAAMMAEELKKEQDTSAH--LERMKK 1788

Query: 1342 RKENIINDLSDKLKSTMQ-QQERDKDLIESLSEDRARLLEEKKKLEEE 1388
              E  + DL  +L    Q   +  K  I+ L E+R R LE +  +E++
Sbjct: 1789 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKL-ENRVRELENELDVEQK 1835



 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 109/513 (21%), Positives = 217/513 (42%), Gaps = 74/513 (14%)

Query: 826  VQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQ--KELLSLKNEYEGKLDGLIK 883
            + K+Q +F   L     E +  +++ +  LE   KE      EL  ++N YE  +D L  
Sbjct: 1446 LDKKQRNFDKVL----AEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQL-- 1499

Query: 884  ETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHS 943
            ET   ENK   L+ E+  L E +          +  K+ V   +++    L E+E  +  
Sbjct: 1500 ETLRRENK--NLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH 1557

Query: 944  QNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAE-------LQSLEQSHLKELEDTLQ 996
            +  +I  ++     V  +L +  +E DE+++ L+         LQS+  + ++   D L+
Sbjct: 1558 EESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALR 1617

Query: 997  VRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDT 1056
            ++     +K+  D      +L   N+Q+     + H   +Q    QL++ +L + D   +
Sbjct: 1618 LK-----KKMEGDLNEMEIQLGHSNRQMAET--QKHLRTVQG---QLKDSQLHLDDALRS 1667

Query: 1057 RCKLEVELALKEAETDEIKILLEESRA--QQKETLKSLLEQETENLRTEISKL---NQKI 1111
               L+ +LA+ E     +   LEE +   +Q E  + L EQE  +    +  L   N  +
Sbjct: 1668 NEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSL 1727

Query: 1112 QDNNENYQVGLAELRTLM--TIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIE 1169
             +  +  +  +A+ +  +  +I++ +   E   +   ++ ++  EL K          ++
Sbjct: 1728 INTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1787

Query: 1170 KNLKEQIIELQSKLD-SELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDRE 1228
            KNL++ + +LQ +LD +E  AL+  K     +Q +K E  ++ LE +             
Sbjct: 1788 KNLEQTVKDLQHRLDEAEQLALKGGK-----KQIQKLENRVRELENE------------- 1829

Query: 1229 QLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLV 1288
                 L+ E+    +      K ER+V  KE+  + +     I +              +
Sbjct: 1830 -----LDVEQKRGAEALKGAHKYERKV--KEMTYQAEEDHKNILR--------------L 1868

Query: 1289 AELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVR 1321
             +L +KLQ +   +  Q EE E++ N ++   R
Sbjct: 1869 QDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCR 1901


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  112 bits (279), Expect = 4e-24
 Identities = 158/716 (22%), Positives = 314/716 (43%), Gaps = 129/716 (18%)

Query: 797  QLERCRVVAQDSHFSI----QTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVK 852
            +LE  +++ +D +  +    + +++ +  F T + +E+ + S SL     +++N  E + 
Sbjct: 975  KLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEE-EKSKSL----AKLKNKHEAMI 1029

Query: 853  CSLEITLK--EKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKD 910
              LE  L+  EK ++EL   + + EG    L  +  E + +I +LK +L   EE LQ   
Sbjct: 1030 TDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQA-- 1087

Query: 911  NEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVEND 970
               AL + E+EA    +N   +K+ E+E    SQ  E++E  +S        +K   +  
Sbjct: 1088 ---ALARVEEEAA--QKNMALKKIRELE----SQISELQEDLESERASRNKAEKQKRDLG 1138

Query: 971  EKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQE 1030
            E+L+ L+ EL           EDTL             D   + +EL+ + +Q +N +++
Sbjct: 1139 EELEALKTEL-----------EDTL-------------DSTAAQQELRSKREQEVNILKK 1174

Query: 1031 SHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLK 1090
            +  E  +  E Q+QE++ K S   +       ELA +  +T  +K  LE++        K
Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQAVE-------ELAEQLEQTKRVKANLEKA--------K 1219

Query: 1091 SLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNI 1150
              LE E   L  E+  L Q   D+                              E +   
Sbjct: 1220 QTLENERGELANEVKVLLQGKGDS------------------------------EHKRKK 1249

Query: 1151 LKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQ 1210
            ++A+L ++    N+   +   L +++ +LQ +LD+ ++ L  Q D K ++  + + A+  
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDN-VTGLLSQSDSKSSKLTKDFSALES 1308

Query: 1211 NLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQ 1270
             L+ D Q+L+  + + +  L  KL   +DE  + + +E   E E  +  L +++  L  Q
Sbjct: 1309 QLQ-DTQELLQEENRQKLSLSTKLKQVEDE--KNSFREQLEEEEEAKHNLEKQIATLHAQ 1365

Query: 1271 IAKSPAIDSTRGDSSSLVAELQEKLQ----------EEKAKFLEQLEEQEKRKNEEMQNV 1320
            +A                 E++ KLQ          EEK    ++LE+ + R  +E+ ++
Sbjct: 1366 VADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDL 1425

Query: 1321 RTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDR----- 1375
               L  ++Q+  N  L +++ + + ++ +  +K  S    +ERD+   E+  ++      
Sbjct: 1426 LVDLDHQRQSACN--LEKKQKKFDQLLAE--EKTISAKYAEERDRAEAEAREKETKALSL 1481

Query: 1376 ARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVD 1435
            AR LEE  + + E+ +L          + ++ +  G    EL  E  + A+E   E    
Sbjct: 1482 ARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHEL--EKSKRALEQQVE---- 1535

Query: 1436 SAMETSMMSVQENIHMLSEEKQRIML--------LERTLQLKEEENKRLNQRLMSQ 1483
              M+T +  +++ +    + K R+ +         ER LQ ++E+++   ++L+ Q
Sbjct: 1536 -EMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQ 1590



 Score =  102 bits (255), Expect = 2e-21
 Identities = 156/751 (20%), Positives = 315/751 (41%), Gaps = 108/751 (14%)

Query: 823  RTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKL---- 878
            R   +K++ D    L+    E+ + ++      E+  K + +  +L    E E K     
Sbjct: 1127 RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ 1186

Query: 879  --------DGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEK 930
                       ++E  E   + K++K  L   ++ L+N+  E A   +E + ++  + + 
Sbjct: 1187 IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELA---NEVKVLLQGKGDS 1243

Query: 931  DQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVE----------NDEKLQLLRAEL 980
            + K  ++E  +     +  E ++ R  + + + KL VE          +D K   L  + 
Sbjct: 1244 EHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDF 1303

Query: 981  QSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKE 1040
             +LE     +L+DT ++  +QE  +        L++++ E      Q++E   E     E
Sbjct: 1304 SALES----QLQDTQEL--LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEE-EAKHNLE 1356

Query: 1041 KQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEES------RAQQK-------E 1087
            KQ+  L  +V+D+     K+E  +   E   +E+K  L++       R ++K       E
Sbjct: 1357 KQIATLHAQVADMKK---KMEDSVGCLET-AEEVKRKLQKDLEGLSQRHEEKVAAYDKLE 1412

Query: 1088 TLKSLLEQETENLRTEISKLNQK---IQDNNENYQVGLAELRTLMTI---EKDQCISEL- 1140
              K+ L+QE ++L  ++    Q    ++   + +   LAE +T+      E+D+  +E  
Sbjct: 1413 KTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAR 1472

Query: 1141 --------ISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALER 1192
                    ++R  EE+   KAEL ++        E   + K+ + +   +L+    ALE+
Sbjct: 1473 EKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQ 1532

Query: 1193 QKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLE 1252
            Q +E  TQ EE  E  +Q  E  + +L  + +  + Q  + L   +DE  +   K+   +
Sbjct: 1533 QVEEMKTQLEE-LEDELQATEDAKLRLEVNLQAMKAQFERDLQ-GRDEQSEEKKKQLVRQ 1590

Query: 1253 REVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKR 1312
               +E EL ++ K     +A    ++    D  + + +   K ++E  K L +L+ Q K 
Sbjct: 1591 VREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHI-DSANKNRDEAIKQLRKLQAQMKD 1649

Query: 1313 KNEEMQNVRTS---LIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQ-QQERDK--D 1366
               E+ + R S   ++A+ + N   + + E    + +  +L+   ++  Q QQERD+  D
Sbjct: 1650 CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ-LQEELAAAERAKRQAQQERDELAD 1708

Query: 1367 LIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAV 1426
             I + S   A  LEEK++LE  +++L                       EL  E   + +
Sbjct: 1709 EIANSSGKGALALEEKRRLEARIAQLEE---------------------ELEEEQGNTEL 1747

Query: 1427 ETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMS 1486
                   ++  ++ + + + +    L+ E+      E   Q  E +NK L  +L      
Sbjct: 1748 -------INDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEME-G 1799

Query: 1487 SVSSRHSEKIAIRDFQVGDLVLIILDERHDN 1517
            +V S++   I   + ++       L+E+ DN
Sbjct: 1800 TVKSKYKASITALEAKIAQ-----LEEQLDN 1825



 Score =  101 bits (252), Expect = 5e-21
 Identities = 126/586 (21%), Positives = 261/586 (44%), Gaps = 79/586 (13%)

Query: 849  EKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQN 908
            E+ K +LE  +   H  ++  +K + E  + G ++  EE + K++K       LE + Q 
Sbjct: 1349 EEAKHNLEKQIATLHA-QVADMKKKMEDSV-GCLETAEEVKRKLQK------DLEGLSQR 1400

Query: 909  KDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVE 968
             + + A     ++    LQ E D  L+++++   S  C +++ ++  + +L + K +  +
Sbjct: 1401 HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA-CNLEKKQKKFDQLLAEEKTISAK 1459

Query: 969  NDEKLQLLRAELQSLEQSHL---KELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQI- 1024
              E+     AE +  E   L   + LE+ ++ +   E E++    R  +E+L      + 
Sbjct: 1460 YAEERDRAEAEAREKETKALSLARALEEAMEQK--AELERLNKQFRTEMEDLMSSKDDVG 1517

Query: 1025 --INQIQESHAEI---IQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETD-EIKILL 1078
              ++++++S   +   ++E + QL+EL+ ++    D + +LEV L   +A+ + +++   
Sbjct: 1518 KSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRD 1577

Query: 1079 EESRAQQKETLKSLLEQETE----------------NLRTEISKLNQKIQDNNENYQVGL 1122
            E+S  ++K+ ++ + E E E                 L  ++  L   I   N+N    +
Sbjct: 1578 EQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAI 1637

Query: 1123 AELRTLMTIEKDQCISELISRHEEESNIL---KAELNKVTSLHNQAFEIEKNL------K 1173
             +LR L    KD C+ EL         IL   K    K+ S+  +  ++++ L      K
Sbjct: 1638 KQLRKLQAQMKD-CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAK 1696

Query: 1174 EQIIELQSKLDSELS--------ALE--RQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQ 1223
             Q  + + +L  E++        ALE  R+ + +I Q EE+ E    N E    +L  + 
Sbjct: 1697 RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKAN 1756

Query: 1224 EQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGD 1283
             Q  +Q+   LN E+  A +      +LER+   KEL  K++ +E  +         +  
Sbjct: 1757 LQ-IDQINTDLNLERSHAQKNENARQQLERQ--NKELKVKLQEMEGTV---------KSK 1804

Query: 1284 SSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRK 1343
              + +  L+ K+    A+  EQL+ + K +    + VR +   E++     +   ++ R 
Sbjct: 1805 YKASITALEAKI----AQLEEQLDNETKERQAACKQVRRT---EKKLKDVLLQVDDERRN 1857

Query: 1344 ENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEV 1389
                 D +DK  + ++Q +R    +E   E+  R    ++KL+ E+
Sbjct: 1858 AEQYKDQADKASTRLKQLKRQ---LEEAEEEAQRANASRRKLQREL 1900


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  111 bits (278), Expect = 5e-24
 Identities = 170/790 (21%), Positives = 336/790 (42%), Gaps = 182/790 (23%)

Query: 847  IIEKVKCSLEITLKEKH---QKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLE 903
            +  KVK  L++T +E+    +++ L    E + K +  +KE E+  +++ + K     L+
Sbjct: 837  LFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN---LLQ 893

Query: 904  EVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLK 963
            E LQ +   +A     +E  + L  +K     E+E I+H     ++E +   + +  + K
Sbjct: 894  EQLQAETELYA---EAEEMRVRLAAKKQ----ELEEILHEMEARLEEEEDRGQQLQAERK 946

Query: 964  KL---HVENDEKLQLLRAELQSLE------QSHLKELEDTLQVRHIQE---------FEK 1005
            K+    ++ +E+L+   A  Q L+      ++ +K+LED + V   Q           E+
Sbjct: 947  KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006

Query: 1006 VMTDHRVSLEELKKENQQIINQIQESHAEIIQE-------KEKQLQEL-KLK-------- 1049
             ++D   +L E ++E  + + +++  H  +I E       +EK  QEL KLK        
Sbjct: 1007 RISDLTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065

Query: 1050 -----VSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSL---------LEQ 1095
                 ++DL     +L+++LA KE E       L++  AQ+   LK +         L++
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125

Query: 1096 ETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILK--- 1152
            + ++ R   +K  ++ +D  E  +    EL    T++      EL ++ E+E  +LK   
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELED--TLDSTATQQELRAKREQEVTVLKKAL 1183

Query: 1153 --------AELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALER------------ 1192
                    A++ ++   H QA E      EQ    ++ LD     LE+            
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243

Query: 1193 -QKDEKITQQEEKYEAIIQNL-------EKDRQKL------------------------- 1219
             Q  +++  +++K EA +Q L       E+ R +L                         
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303

Query: 1220 ---------VSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQ 1270
                     +SSQ QD ++L+Q+   +K   + T L++ + ER  ++ +L E+++  +N 
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362

Query: 1271 IAKSPAIDSTRGDS-------SSLVAELQE-------------KLQEEKAKFLEQLEEQE 1310
                  ++    DS       +S V  L+E             +  EEKA   ++LE+ +
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422

Query: 1311 KRKNEEMQNVRTSL---------IAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQ 1361
             R  +E+ ++   L         + ++Q  F+ +L  EK    NI +  +D+ +   + +
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK----NISSKYADE-RDRAEAE 1477

Query: 1362 ERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGES 1421
             R+K   E+ +   AR LEE  + +EE+ +           + ++ +  G    EL  E 
Sbjct: 1478 AREK---ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL--EK 1532

Query: 1422 DRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIML--------LERTLQLKEEEN 1473
             + A+ET  E      M+T +  +++ +    + K R+ +         ER LQ ++E+N
Sbjct: 1533 SKRALETQME-----EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1587

Query: 1474 KRLNQRLMSQ 1483
            +   ++L  Q
Sbjct: 1588 EEKRRQLQRQ 1597



 Score =  100 bits (248), Expect = 1e-20
 Identities = 148/693 (21%), Positives = 301/693 (43%), Gaps = 94/693 (13%)

Query: 861  EKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFA------ 914
            +K+++ L     +  G+L  L +  +E E+K KKL+ ++  L+    + +   A      
Sbjct: 1223 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV 1282

Query: 915  -LVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLK-KLHVENDEK 972
              +++E E+V  + NE + K +++   + S +    +L+ ++E++ E+ + KL+V    K
Sbjct: 1283 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLS---SQLQDTQELLQEETRQKLNVST--K 1337

Query: 973  LQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESH 1032
            L+ L  E  SL+     +L++ ++ +  Q  E+ ++   + L + KK+ Q   + + E+ 
Sbjct: 1338 LRQLEEERNSLQD----QLDEEMEAK--QNLERHISTLNIQLSDSKKKLQDFASTV-EAL 1390

Query: 1033 AEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSL 1092
             E  +  +K+++ L  +  + +    KLE      + E D++ + L+  R       K  
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK- 1449

Query: 1093 LEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEE---ESN 1149
             +++ + L  E   ++ K  D  +  +    E  T   +   + + E +   EE    + 
Sbjct: 1450 -QRKFDQLLAEEKNISSKYADERDRAEAEAREKET-KALSLARALEEALEAKEELERTNK 1507

Query: 1150 ILKAELNKVTS----LHNQAFEIEKN---LKEQIIELQSKLDSELSALERQKDEKITQQE 1202
            +LKAE+  + S    +     E+EK+   L+ Q+ E++++L+     L+  +D K+ + E
Sbjct: 1508 MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL-RLE 1566

Query: 1203 EKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEK----DEAIQTAL------------ 1246
               +A+    E+D Q      E+ R QL ++L+  +    DE  Q AL            
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1626

Query: 1247 KEFKLEREVVEKELLEKVKHLENQIAKSP----AIDSTRGDSSSLVAELQEKLQEEKAKF 1302
            K+ +L+ +   K   E +K L    A+       ++  R     + A  +E   E+KAK 
Sbjct: 1627 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN--EKKAKS 1684

Query: 1303 LE----QLEE-----QEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDK 1353
            LE    QL+E     +  RK  +++    +       +    L  EK R E  I  L ++
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744

Query: 1354 LKSTMQQQERDKDLIESLSEDRARLLEE--------------KKKLEEEVSKLRSS---- 1395
            L+      E   D +   ++   +L  E              +++LE +  +LRS     
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804

Query: 1396 -SFVPSPYVATAPELYGACAP---ELPGESDRSAVETADEGRVDSAMETSMMSVQENIHM 1451
               V S + +T   L    A    ++  E+      T    + D  ++  ++ V++   M
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1864

Query: 1452 LSEEKQ-------RIMLLERTLQLKEEENKRLN 1477
              + K+       R+  L+R L+  EEE++R+N
Sbjct: 1865 AEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897



 Score = 91.7 bits (226), Expect = 5e-18
 Identities = 145/673 (21%), Positives = 284/673 (42%), Gaps = 93/673 (13%)

Query: 774  SRRMQDTNVCGKEDFGDHTSLNV---QLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQ 830
            S ++QDT    +E+     +++    QLE  R   QD        K++L    + +  + 
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1373

Query: 831  CDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENEN 890
             D    L+  A  +  + E          K++ QKE+ +L  +YE K     K  E+ +N
Sbjct: 1374 SDSKKKLQDFASTVEALEEG---------KKRFQKEIENLTQQYEEKAAAYDK-LEKTKN 1423

Query: 891  KIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKE 950
            ++++       L++++ + DN+  LV + ++     Q + DQ L E +NI      E   
Sbjct: 1424 RLQQE------LDDLVVDLDNQRQLVSNLEKK----QRKFDQLLAEEKNISSKYADERDR 1473

Query: 951  LK-QSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTD 1009
             + ++RE           +  + L L RA  ++LE     E  + +    +++      D
Sbjct: 1474 AEAEARE-----------KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522

Query: 1010 HRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVEL-ALKE 1068
               ++ EL+K  + +  Q++E         + QL+EL+ ++    D + +LEV + ALK 
Sbjct: 1523 VGKNVHELEKSKRALETQMEEM--------KTQLEELEDELQATEDAKLRLEVNMQALKG 1574

Query: 1069 AETDEIKILLEESRAQQKETLKSLLEQETE----------------NLRTEISKLNQKIQ 1112
                +++   E++  ++++  + L E ETE                 L  ++  L  +  
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634

Query: 1113 DNNENYQVGLAELRTLMTIEKD------------QCISELISRHEEESNILKAELNKVTS 1160
               +  +  + +LR L    KD              I      +E+++  L+A+L ++  
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1694

Query: 1161 LHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEK------ITQQEEKYEAIIQNLEK 1214
                A    K    +  EL  +L S LS     +DEK      I Q EE+ E    N+E 
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754

Query: 1215 DRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKS 1274
               + V    Q  EQL  +L  E+  A +      +LER+   KEL  K+  +E  +   
Sbjct: 1755 MSDR-VRKATQQAEQLSNELATERSTAQKNESARQQLERQ--NKELRSKLHEMEGAVKSK 1811

Query: 1275 PAIDSTRGDSSSLVAELQEKLQE---EKAKFLEQLEEQEKRKNEEMQNVRTS-LIAEQ-- 1328
                ST     + +A+L+E++++   EK    + L++++K+  E +  V     +AEQ  
Sbjct: 1812 --FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1869

Query: 1329 -QTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEE 1387
             Q        ++  R+     + S ++ +  ++ +R+   ++  +E    +  E   L+ 
Sbjct: 1870 EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE---LDEATESNEAMGREVNALKS 1926

Query: 1388 EVSKLRSSSFVPS 1400
            ++ +   +SFVPS
Sbjct: 1927 KLRRGNETSFVPS 1939



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 94/414 (22%), Positives = 178/414 (42%), Gaps = 32/414 (7%)

Query: 1103 EISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLH 1162
            E+     ++Q   E  Q    EL+ L     +Q  S+L     EE N+L+ +L   T L+
Sbjct: 853  EMQAKEDELQKTKERQQKAENELKEL-----EQKHSQLT----EEKNLLQEQLQAETELY 903

Query: 1163 NQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSS 1222
             +A E+   L  +  EL+  L    + LE ++D     Q E+ +   Q L+ + Q  +  
Sbjct: 904  AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ--LEE 961

Query: 1223 QEQDREQL-IQKLNCE------KDEAIQTALKEFKL--EREVVEKELLEKVKHLENQIAK 1273
            +E  R++L ++K+  E      +DE +    +  KL  ER+++E+ + +   +L  +  K
Sbjct: 962  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021

Query: 1274 SPAIDSTRGDSSSLVAEL------QEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSL--I 1325
            +  +   +    S+++EL      +EK ++E  K   +LE      +E++ +++  +  +
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081

Query: 1326 AEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRA---RLLEEK 1382
              Q       L     R ++ I   ++ LK   + +    DL E L  +RA   +  ++K
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141

Query: 1383 KKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVET-ADEGRVDSAMETS 1441
            + L EE+  L++         AT  EL      E+         ET + E +V    +  
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201

Query: 1442 MMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEK 1495
              +V+E    L + K+    L++  Q  E+EN  L   L     +     H +K
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 34/163 (20%), Positives = 72/163 (44%), Gaps = 20/163 (12%)

Query: 1342 RKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSP 1401
            R+E  +    D+L+ T ++Q++ ++ ++ L +  ++L EEK  L+E++            
Sbjct: 849  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ----------- 897

Query: 1402 YVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRI-- 1459
                  ELY     E      R A +  +   +   ME  +   ++    L  E++++  
Sbjct: 898  ---AETELYA----EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ 950

Query: 1460 MLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEKIAIRDFQ 1502
             +L+   QL+EEE  R   +L   +  +   +  ++I + D Q
Sbjct: 951  QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  111 bits (278), Expect = 5e-24
 Identities = 170/790 (21%), Positives = 336/790 (42%), Gaps = 182/790 (23%)

Query: 847  IIEKVKCSLEITLKEKH---QKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLE 903
            +  KVK  L++T +E+    +++ L    E + K +  +KE E+  +++ + K     L+
Sbjct: 844  LFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN---LLQ 900

Query: 904  EVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLK 963
            E LQ +   +A     +E  + L  +K     E+E I+H     ++E +   + +  + K
Sbjct: 901  EQLQAETELYA---EAEEMRVRLAAKKQ----ELEEILHEMEARLEEEEDRGQQLQAERK 953

Query: 964  KL---HVENDEKLQLLRAELQSLE------QSHLKELEDTLQVRHIQE---------FEK 1005
            K+    ++ +E+L+   A  Q L+      ++ +K+LED + V   Q           E+
Sbjct: 954  KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013

Query: 1006 VMTDHRVSLEELKKENQQIINQIQESHAEIIQE-------KEKQLQEL-KLK-------- 1049
             ++D   +L E ++E  + + +++  H  +I E       +EK  QEL KLK        
Sbjct: 1014 RISDLTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072

Query: 1050 -----VSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSL---------LEQ 1095
                 ++DL     +L+++LA KE E       L++  AQ+   LK +         L++
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132

Query: 1096 ETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILK--- 1152
            + ++ R   +K  ++ +D  E  +    EL    T++      EL ++ E+E  +LK   
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELED--TLDSTATQQELRAKREQEVTVLKKAL 1190

Query: 1153 --------AELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALER------------ 1192
                    A++ ++   H QA E      EQ    ++ LD     LE+            
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250

Query: 1193 -QKDEKITQQEEKYEAIIQNL-------EKDRQKL------------------------- 1219
             Q  +++  +++K EA +Q L       E+ R +L                         
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310

Query: 1220 ---------VSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQ 1270
                     +SSQ QD ++L+Q+   +K   + T L++ + ER  ++ +L E+++  +N 
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369

Query: 1271 IAKSPAIDSTRGDS-------SSLVAELQE-------------KLQEEKAKFLEQLEEQE 1310
                  ++    DS       +S V  L+E             +  EEKA   ++LE+ +
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429

Query: 1311 KRKNEEMQNVRTSL---------IAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQ 1361
             R  +E+ ++   L         + ++Q  F+ +L  EK    NI +  +D+ +   + +
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK----NISSKYADE-RDRAEAE 1484

Query: 1362 ERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGES 1421
             R+K   E+ +   AR LEE  + +EE+ +           + ++ +  G    EL  E 
Sbjct: 1485 AREK---ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL--EK 1539

Query: 1422 DRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIML--------LERTLQLKEEEN 1473
             + A+ET  E      M+T +  +++ +    + K R+ +         ER LQ ++E+N
Sbjct: 1540 SKRALETQME-----EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1594

Query: 1474 KRLNQRLMSQ 1483
            +   ++L  Q
Sbjct: 1595 EEKRRQLQRQ 1604



 Score =  100 bits (248), Expect = 1e-20
 Identities = 148/693 (21%), Positives = 301/693 (43%), Gaps = 94/693 (13%)

Query: 861  EKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFA------ 914
            +K+++ L     +  G+L  L +  +E E+K KKL+ ++  L+    + +   A      
Sbjct: 1230 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV 1289

Query: 915  -LVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLK-KLHVENDEK 972
              +++E E+V  + NE + K +++   + S +    +L+ ++E++ E+ + KL+V    K
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLS---SQLQDTQELLQEETRQKLNVST--K 1344

Query: 973  LQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESH 1032
            L+ L  E  SL+     +L++ ++ +  Q  E+ ++   + L + KK+ Q   + + E+ 
Sbjct: 1345 LRQLEEERNSLQD----QLDEEMEAK--QNLERHISTLNIQLSDSKKKLQDFASTV-EAL 1397

Query: 1033 AEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSL 1092
             E  +  +K+++ L  +  + +    KLE      + E D++ + L+  R       K  
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK- 1456

Query: 1093 LEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEE---ESN 1149
             +++ + L  E   ++ K  D  +  +    E  T   +   + + E +   EE    + 
Sbjct: 1457 -QRKFDQLLAEEKNISSKYADERDRAEAEAREKET-KALSLARALEEALEAKEELERTNK 1514

Query: 1150 ILKAELNKVTS----LHNQAFEIEKN---LKEQIIELQSKLDSELSALERQKDEKITQQE 1202
            +LKAE+  + S    +     E+EK+   L+ Q+ E++++L+     L+  +D K+ + E
Sbjct: 1515 MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL-RLE 1573

Query: 1203 EKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEK----DEAIQTAL------------ 1246
               +A+    E+D Q      E+ R QL ++L+  +    DE  Q AL            
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633

Query: 1247 KEFKLEREVVEKELLEKVKHLENQIAKSP----AIDSTRGDSSSLVAELQEKLQEEKAKF 1302
            K+ +L+ +   K   E +K L    A+       ++  R     + A  +E   E+KAK 
Sbjct: 1634 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN--EKKAKS 1691

Query: 1303 LE----QLEE-----QEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDK 1353
            LE    QL+E     +  RK  +++    +       +    L  EK R E  I  L ++
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751

Query: 1354 LKSTMQQQERDKDLIESLSEDRARLLEE--------------KKKLEEEVSKLRSS---- 1395
            L+      E   D +   ++   +L  E              +++LE +  +LRS     
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811

Query: 1396 -SFVPSPYVATAPELYGACAP---ELPGESDRSAVETADEGRVDSAMETSMMSVQENIHM 1451
               V S + +T   L    A    ++  E+      T    + D  ++  ++ V++   M
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1871

Query: 1452 LSEEKQ-------RIMLLERTLQLKEEENKRLN 1477
              + K+       R+  L+R L+  EEE++R+N
Sbjct: 1872 AEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904



 Score = 91.7 bits (226), Expect = 5e-18
 Identities = 145/673 (21%), Positives = 284/673 (42%), Gaps = 93/673 (13%)

Query: 774  SRRMQDTNVCGKEDFGDHTSLNV---QLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQ 830
            S ++QDT    +E+     +++    QLE  R   QD        K++L    + +  + 
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1380

Query: 831  CDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENEN 890
             D    L+  A  +  + E          K++ QKE+ +L  +YE K     K  E+ +N
Sbjct: 1381 SDSKKKLQDFASTVEALEEG---------KKRFQKEIENLTQQYEEKAAAYDK-LEKTKN 1430

Query: 891  KIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKE 950
            ++++       L++++ + DN+  LV + ++     Q + DQ L E +NI      E   
Sbjct: 1431 RLQQE------LDDLVVDLDNQRQLVSNLEKK----QRKFDQLLAEEKNISSKYADERDR 1480

Query: 951  LK-QSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTD 1009
             + ++RE           +  + L L RA  ++LE     E  + +    +++      D
Sbjct: 1481 AEAEARE-----------KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529

Query: 1010 HRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVEL-ALKE 1068
               ++ EL+K  + +  Q++E         + QL+EL+ ++    D + +LEV + ALK 
Sbjct: 1530 VGKNVHELEKSKRALETQMEEM--------KTQLEELEDELQATEDAKLRLEVNMQALKG 1581

Query: 1069 AETDEIKILLEESRAQQKETLKSLLEQETE----------------NLRTEISKLNQKIQ 1112
                +++   E++  ++++  + L E ETE                 L  ++  L  +  
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641

Query: 1113 DNNENYQVGLAELRTLMTIEKD------------QCISELISRHEEESNILKAELNKVTS 1160
               +  +  + +LR L    KD              I      +E+++  L+A+L ++  
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1701

Query: 1161 LHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEK------ITQQEEKYEAIIQNLEK 1214
                A    K    +  EL  +L S LS     +DEK      I Q EE+ E    N+E 
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761

Query: 1215 DRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKS 1274
               + V    Q  EQL  +L  E+  A +      +LER+   KEL  K+  +E  +   
Sbjct: 1762 MSDR-VRKATQQAEQLSNELATERSTAQKNESARQQLERQ--NKELRSKLHEMEGAVKSK 1818

Query: 1275 PAIDSTRGDSSSLVAELQEKLQE---EKAKFLEQLEEQEKRKNEEMQNVRTS-LIAEQ-- 1328
                ST     + +A+L+E++++   EK    + L++++K+  E +  V     +AEQ  
Sbjct: 1819 --FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1876

Query: 1329 -QTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEE 1387
             Q        ++  R+     + S ++ +  ++ +R+   ++  +E    +  E   L+ 
Sbjct: 1877 EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE---LDEATESNEAMGREVNALKS 1933

Query: 1388 EVSKLRSSSFVPS 1400
            ++ +   +SFVPS
Sbjct: 1934 KLRRGNETSFVPS 1946



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 94/414 (22%), Positives = 178/414 (42%), Gaps = 32/414 (7%)

Query: 1103 EISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLH 1162
            E+     ++Q   E  Q    EL+ L     +Q  S+L     EE N+L+ +L   T L+
Sbjct: 860  EMQAKEDELQKTKERQQKAENELKEL-----EQKHSQLT----EEKNLLQEQLQAETELY 910

Query: 1163 NQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSS 1222
             +A E+   L  +  EL+  L    + LE ++D     Q E+ +   Q L+ + Q  +  
Sbjct: 911  AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ--LEE 968

Query: 1223 QEQDREQL-IQKLNCE------KDEAIQTALKEFKL--EREVVEKELLEKVKHLENQIAK 1273
            +E  R++L ++K+  E      +DE +    +  KL  ER+++E+ + +   +L  +  K
Sbjct: 969  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028

Query: 1274 SPAIDSTRGDSSSLVAEL------QEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSL--I 1325
            +  +   +    S+++EL      +EK ++E  K   +LE      +E++ +++  +  +
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088

Query: 1326 AEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRA---RLLEEK 1382
              Q       L     R ++ I   ++ LK   + +    DL E L  +RA   +  ++K
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148

Query: 1383 KKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVET-ADEGRVDSAMETS 1441
            + L EE+  L++         AT  EL      E+         ET + E +V    +  
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208

Query: 1442 MMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEK 1495
              +V+E    L + K+    L++  Q  E+EN  L   L     +     H +K
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 34/163 (20%), Positives = 72/163 (44%), Gaps = 20/163 (12%)

Query: 1342 RKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSP 1401
            R+E  +    D+L+ T ++Q++ ++ ++ L +  ++L EEK  L+E++            
Sbjct: 856  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ----------- 904

Query: 1402 YVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRI-- 1459
                  ELY     E      R A +  +   +   ME  +   ++    L  E++++  
Sbjct: 905  ---AETELYA----EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ 957

Query: 1460 MLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEKIAIRDFQ 1502
             +L+   QL+EEE  R   +L   +  +   +  ++I + D Q
Sbjct: 958  QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  111 bits (278), Expect = 5e-24
 Identities = 170/790 (21%), Positives = 336/790 (42%), Gaps = 182/790 (23%)

Query: 847  IIEKVKCSLEITLKEKH---QKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLE 903
            +  KVK  L++T +E+    +++ L    E + K +  +KE E+  +++ + K     L+
Sbjct: 844  LFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN---LLQ 900

Query: 904  EVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLK 963
            E LQ +   +A     +E  + L  +K     E+E I+H     ++E +   + +  + K
Sbjct: 901  EQLQAETELYA---EAEEMRVRLAAKKQ----ELEEILHEMEARLEEEEDRGQQLQAERK 953

Query: 964  KL---HVENDEKLQLLRAELQSLE------QSHLKELEDTLQVRHIQE---------FEK 1005
            K+    ++ +E+L+   A  Q L+      ++ +K+LED + V   Q           E+
Sbjct: 954  KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013

Query: 1006 VMTDHRVSLEELKKENQQIINQIQESHAEIIQE-------KEKQLQEL-KLK-------- 1049
             ++D   +L E ++E  + + +++  H  +I E       +EK  QEL KLK        
Sbjct: 1014 RISDLTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072

Query: 1050 -----VSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSL---------LEQ 1095
                 ++DL     +L+++LA KE E       L++  AQ+   LK +         L++
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132

Query: 1096 ETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILK--- 1152
            + ++ R   +K  ++ +D  E  +    EL    T++      EL ++ E+E  +LK   
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELED--TLDSTATQQELRAKREQEVTVLKKAL 1190

Query: 1153 --------AELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALER------------ 1192
                    A++ ++   H QA E      EQ    ++ LD     LE+            
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250

Query: 1193 -QKDEKITQQEEKYEAIIQNL-------EKDRQKL------------------------- 1219
             Q  +++  +++K EA +Q L       E+ R +L                         
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310

Query: 1220 ---------VSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQ 1270
                     +SSQ QD ++L+Q+   +K   + T L++ + ER  ++ +L E+++  +N 
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369

Query: 1271 IAKSPAIDSTRGDS-------SSLVAELQE-------------KLQEEKAKFLEQLEEQE 1310
                  ++    DS       +S V  L+E             +  EEKA   ++LE+ +
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429

Query: 1311 KRKNEEMQNVRTSL---------IAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQ 1361
             R  +E+ ++   L         + ++Q  F+ +L  EK    NI +  +D+ +   + +
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK----NISSKYADE-RDRAEAE 1484

Query: 1362 ERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGES 1421
             R+K   E+ +   AR LEE  + +EE+ +           + ++ +  G    EL  E 
Sbjct: 1485 AREK---ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL--EK 1539

Query: 1422 DRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIML--------LERTLQLKEEEN 1473
             + A+ET  E      M+T +  +++ +    + K R+ +         ER LQ ++E+N
Sbjct: 1540 SKRALETQME-----EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1594

Query: 1474 KRLNQRLMSQ 1483
            +   ++L  Q
Sbjct: 1595 EEKRRQLQRQ 1604



 Score =  100 bits (248), Expect = 1e-20
 Identities = 148/693 (21%), Positives = 301/693 (43%), Gaps = 94/693 (13%)

Query: 861  EKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFA------ 914
            +K+++ L     +  G+L  L +  +E E+K KKL+ ++  L+    + +   A      
Sbjct: 1230 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV 1289

Query: 915  -LVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLK-KLHVENDEK 972
              +++E E+V  + NE + K +++   + S +    +L+ ++E++ E+ + KL+V    K
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLS---SQLQDTQELLQEETRQKLNVST--K 1344

Query: 973  LQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESH 1032
            L+ L  E  SL+     +L++ ++ +  Q  E+ ++   + L + KK+ Q   + + E+ 
Sbjct: 1345 LRQLEEERNSLQD----QLDEEMEAK--QNLERHISTLNIQLSDSKKKLQDFASTV-EAL 1397

Query: 1033 AEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSL 1092
             E  +  +K+++ L  +  + +    KLE      + E D++ + L+  R       K  
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK- 1456

Query: 1093 LEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEE---ESN 1149
             +++ + L  E   ++ K  D  +  +    E  T   +   + + E +   EE    + 
Sbjct: 1457 -QRKFDQLLAEEKNISSKYADERDRAEAEAREKET-KALSLARALEEALEAKEELERTNK 1514

Query: 1150 ILKAELNKVTS----LHNQAFEIEKN---LKEQIIELQSKLDSELSALERQKDEKITQQE 1202
            +LKAE+  + S    +     E+EK+   L+ Q+ E++++L+     L+  +D K+ + E
Sbjct: 1515 MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL-RLE 1573

Query: 1203 EKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEK----DEAIQTAL------------ 1246
               +A+    E+D Q      E+ R QL ++L+  +    DE  Q AL            
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633

Query: 1247 KEFKLEREVVEKELLEKVKHLENQIAKSP----AIDSTRGDSSSLVAELQEKLQEEKAKF 1302
            K+ +L+ +   K   E +K L    A+       ++  R     + A  +E   E+KAK 
Sbjct: 1634 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN--EKKAKS 1691

Query: 1303 LE----QLEE-----QEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDK 1353
            LE    QL+E     +  RK  +++    +       +    L  EK R E  I  L ++
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751

Query: 1354 LKSTMQQQERDKDLIESLSEDRARLLEE--------------KKKLEEEVSKLRSS---- 1395
            L+      E   D +   ++   +L  E              +++LE +  +LRS     
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811

Query: 1396 -SFVPSPYVATAPELYGACAP---ELPGESDRSAVETADEGRVDSAMETSMMSVQENIHM 1451
               V S + +T   L    A    ++  E+      T    + D  ++  ++ V++   M
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1871

Query: 1452 LSEEKQ-------RIMLLERTLQLKEEENKRLN 1477
              + K+       R+  L+R L+  EEE++R+N
Sbjct: 1872 AEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 147/672 (21%), Positives = 279/672 (41%), Gaps = 96/672 (14%)

Query: 774  SRRMQDTNVCGKEDFGDHTSLNV---QLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQ 830
            S ++QDT    +E+     +++    QLE  R   QD        K++L    + +  + 
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1380

Query: 831  CDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENEN 890
             D    L+  A  +  + E          K++ QKE+ +L  +YE K     K  E+ +N
Sbjct: 1381 SDSKKKLQDFASTVEALEEG---------KKRFQKEIENLTQQYEEKAAAYDK-LEKTKN 1430

Query: 891  KIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKE 950
            ++++       L++++ + DN+  LV + ++     Q + DQ L E +NI      E   
Sbjct: 1431 RLQQE------LDDLVVDLDNQRQLVSNLEKK----QRKFDQLLAEEKNISSKYADERDR 1480

Query: 951  LK-QSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTD 1009
             + ++RE           +  + L L RA  ++LE     E  + +    +++      D
Sbjct: 1481 AEAEARE-----------KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529

Query: 1010 HRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVEL-ALKE 1068
               ++ EL+K  + +  Q++E         + QL+EL+ ++    D + +LEV + ALK 
Sbjct: 1530 VGKNVHELEKSKRALETQMEEM--------KTQLEELEDELQATEDAKLRLEVNMQALKG 1581

Query: 1069 AETDEIKILLEESRAQQKETLKSLLEQETE----------------NLRTEISKLNQKIQ 1112
                +++   E++  ++++  + L E ETE                 L  ++  L  +  
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641

Query: 1113 DNNENYQVGLAELRTLMTIEKD------------QCISELISRHEEESNILKAELNKVTS 1160
               +  +  + +LR L    KD              I      +E+++  L+A+L ++  
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1701

Query: 1161 LHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEK------ITQQEEKYEAIIQNLEK 1214
                A    K    +  EL  +L S LS     +DEK      I Q EE+ E    N+E 
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761

Query: 1215 DRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKS 1274
               + V    Q  EQL  +L  E+  A +      +LER+   KEL  K+  +E  +   
Sbjct: 1762 MSDR-VRKATQQAEQLSNELATERSTAQKNESARQQLERQ--NKELRSKLHEMEGAVKSK 1818

Query: 1275 PAIDSTRGDSSSLVAELQEKLQE---EKAKFLEQLEEQEKRKNEEMQNVRTS-LIAEQQT 1330
                ST     + +A+L+E++++   EK    + L++++K+  E +  V     +AEQ  
Sbjct: 1819 --FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY- 1875

Query: 1331 NFNTVLTREKMRKENI-INDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEV 1389
                   +E+  K N  +  L  +L+   ++ +R       L  +     E  + +  EV
Sbjct: 1876 -------KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1928

Query: 1390 SKLRSSSFVPSP 1401
            + L+S    P P
Sbjct: 1929 NALKSKLRGPPP 1940



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 94/414 (22%), Positives = 178/414 (42%), Gaps = 32/414 (7%)

Query: 1103 EISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLH 1162
            E+     ++Q   E  Q    EL+ L     +Q  S+L     EE N+L+ +L   T L+
Sbjct: 860  EMQAKEDELQKTKERQQKAENELKEL-----EQKHSQLT----EEKNLLQEQLQAETELY 910

Query: 1163 NQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSS 1222
             +A E+   L  +  EL+  L    + LE ++D     Q E+ +   Q L+ + Q  +  
Sbjct: 911  AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ--LEE 968

Query: 1223 QEQDREQL-IQKLNCE------KDEAIQTALKEFKL--EREVVEKELLEKVKHLENQIAK 1273
            +E  R++L ++K+  E      +DE +    +  KL  ER+++E+ + +   +L  +  K
Sbjct: 969  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028

Query: 1274 SPAIDSTRGDSSSLVAEL------QEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSL--I 1325
            +  +   +    S+++EL      +EK ++E  K   +LE      +E++ +++  +  +
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088

Query: 1326 AEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRA---RLLEEK 1382
              Q       L     R ++ I   ++ LK   + +    DL E L  +RA   +  ++K
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148

Query: 1383 KKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVET-ADEGRVDSAMETS 1441
            + L EE+  L++         AT  EL      E+         ET + E +V    +  
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208

Query: 1442 MMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEK 1495
              +V+E    L + K+    L++  Q  E+EN  L   L     +     H +K
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 34/163 (20%), Positives = 72/163 (44%), Gaps = 20/163 (12%)

Query: 1342 RKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSP 1401
            R+E  +    D+L+ T ++Q++ ++ ++ L +  ++L EEK  L+E++            
Sbjct: 856  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ----------- 904

Query: 1402 YVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRI-- 1459
                  ELY     E      R A +  +   +   ME  +   ++    L  E++++  
Sbjct: 905  ---AETELYA----EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ 957

Query: 1460 MLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEKIAIRDFQ 1502
             +L+   QL+EEE  R   +L   +  +   +  ++I + D Q
Sbjct: 958  QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  111 bits (278), Expect = 5e-24
 Identities = 170/790 (21%), Positives = 336/790 (42%), Gaps = 182/790 (23%)

Query: 847  IIEKVKCSLEITLKEKH---QKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLE 903
            +  KVK  L++T +E+    +++ L    E + K +  +KE E+  +++ + K     L+
Sbjct: 837  LFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN---LLQ 893

Query: 904  EVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLK 963
            E LQ +   +A     +E  + L  +K     E+E I+H     ++E +   + +  + K
Sbjct: 894  EQLQAETELYA---EAEEMRVRLAAKKQ----ELEEILHEMEARLEEEEDRGQQLQAERK 946

Query: 964  KL---HVENDEKLQLLRAELQSLE------QSHLKELEDTLQVRHIQE---------FEK 1005
            K+    ++ +E+L+   A  Q L+      ++ +K+LED + V   Q           E+
Sbjct: 947  KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006

Query: 1006 VMTDHRVSLEELKKENQQIINQIQESHAEIIQE-------KEKQLQEL-KLK-------- 1049
             ++D   +L E ++E  + + +++  H  +I E       +EK  QEL KLK        
Sbjct: 1007 RISDLTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065

Query: 1050 -----VSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSL---------LEQ 1095
                 ++DL     +L+++LA KE E       L++  AQ+   LK +         L++
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125

Query: 1096 ETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILK--- 1152
            + ++ R   +K  ++ +D  E  +    EL    T++      EL ++ E+E  +LK   
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELED--TLDSTATQQELRAKREQEVTVLKKAL 1183

Query: 1153 --------AELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALER------------ 1192
                    A++ ++   H QA E      EQ    ++ LD     LE+            
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243

Query: 1193 -QKDEKITQQEEKYEAIIQNL-------EKDRQKL------------------------- 1219
             Q  +++  +++K EA +Q L       E+ R +L                         
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303

Query: 1220 ---------VSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQ 1270
                     +SSQ QD ++L+Q+   +K   + T L++ + ER  ++ +L E+++  +N 
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362

Query: 1271 IAKSPAIDSTRGDS-------SSLVAELQE-------------KLQEEKAKFLEQLEEQE 1310
                  ++    DS       +S V  L+E             +  EEKA   ++LE+ +
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422

Query: 1311 KRKNEEMQNVRTSL---------IAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQ 1361
             R  +E+ ++   L         + ++Q  F+ +L  EK    NI +  +D+ +   + +
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK----NISSKYADE-RDRAEAE 1477

Query: 1362 ERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGES 1421
             R+K   E+ +   AR LEE  + +EE+ +           + ++ +  G    EL  E 
Sbjct: 1478 AREK---ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL--EK 1532

Query: 1422 DRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIML--------LERTLQLKEEEN 1473
             + A+ET  E      M+T +  +++ +    + K R+ +         ER LQ ++E+N
Sbjct: 1533 SKRALETQME-----EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1587

Query: 1474 KRLNQRLMSQ 1483
            +   ++L  Q
Sbjct: 1588 EEKRRQLQRQ 1597



 Score =  100 bits (248), Expect = 1e-20
 Identities = 148/693 (21%), Positives = 301/693 (43%), Gaps = 94/693 (13%)

Query: 861  EKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFA------ 914
            +K+++ L     +  G+L  L +  +E E+K KKL+ ++  L+    + +   A      
Sbjct: 1223 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV 1282

Query: 915  -LVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLK-KLHVENDEK 972
              +++E E+V  + NE + K +++   + S +    +L+ ++E++ E+ + KL+V    K
Sbjct: 1283 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLS---SQLQDTQELLQEETRQKLNVST--K 1337

Query: 973  LQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESH 1032
            L+ L  E  SL+     +L++ ++ +  Q  E+ ++   + L + KK+ Q   + + E+ 
Sbjct: 1338 LRQLEEERNSLQD----QLDEEMEAK--QNLERHISTLNIQLSDSKKKLQDFASTV-EAL 1390

Query: 1033 AEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSL 1092
             E  +  +K+++ L  +  + +    KLE      + E D++ + L+  R       K  
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK- 1449

Query: 1093 LEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEE---ESN 1149
             +++ + L  E   ++ K  D  +  +    E  T   +   + + E +   EE    + 
Sbjct: 1450 -QRKFDQLLAEEKNISSKYADERDRAEAEAREKET-KALSLARALEEALEAKEELERTNK 1507

Query: 1150 ILKAELNKVTS----LHNQAFEIEKN---LKEQIIELQSKLDSELSALERQKDEKITQQE 1202
            +LKAE+  + S    +     E+EK+   L+ Q+ E++++L+     L+  +D K+ + E
Sbjct: 1508 MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL-RLE 1566

Query: 1203 EKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEK----DEAIQTAL------------ 1246
               +A+    E+D Q      E+ R QL ++L+  +    DE  Q AL            
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1626

Query: 1247 KEFKLEREVVEKELLEKVKHLENQIAKSP----AIDSTRGDSSSLVAELQEKLQEEKAKF 1302
            K+ +L+ +   K   E +K L    A+       ++  R     + A  +E   E+KAK 
Sbjct: 1627 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN--EKKAKS 1684

Query: 1303 LE----QLEE-----QEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDK 1353
            LE    QL+E     +  RK  +++    +       +    L  EK R E  I  L ++
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744

Query: 1354 LKSTMQQQERDKDLIESLSEDRARLLEE--------------KKKLEEEVSKLRSS---- 1395
            L+      E   D +   ++   +L  E              +++LE +  +LRS     
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804

Query: 1396 -SFVPSPYVATAPELYGACAP---ELPGESDRSAVETADEGRVDSAMETSMMSVQENIHM 1451
               V S + +T   L    A    ++  E+      T    + D  ++  ++ V++   M
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1864

Query: 1452 LSEEKQ-------RIMLLERTLQLKEEENKRLN 1477
              + K+       R+  L+R L+  EEE++R+N
Sbjct: 1865 AEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 147/672 (21%), Positives = 279/672 (41%), Gaps = 96/672 (14%)

Query: 774  SRRMQDTNVCGKEDFGDHTSLNV---QLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQ 830
            S ++QDT    +E+     +++    QLE  R   QD        K++L    + +  + 
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1373

Query: 831  CDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENEN 890
             D    L+  A  +  + E          K++ QKE+ +L  +YE K     K  E+ +N
Sbjct: 1374 SDSKKKLQDFASTVEALEEG---------KKRFQKEIENLTQQYEEKAAAYDK-LEKTKN 1423

Query: 891  KIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKE 950
            ++++       L++++ + DN+  LV + ++     Q + DQ L E +NI      E   
Sbjct: 1424 RLQQE------LDDLVVDLDNQRQLVSNLEKK----QRKFDQLLAEEKNISSKYADERDR 1473

Query: 951  LK-QSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTD 1009
             + ++RE           +  + L L RA  ++LE     E  + +    +++      D
Sbjct: 1474 AEAEARE-----------KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522

Query: 1010 HRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVEL-ALKE 1068
               ++ EL+K  + +  Q++E         + QL+EL+ ++    D + +LEV + ALK 
Sbjct: 1523 VGKNVHELEKSKRALETQMEEM--------KTQLEELEDELQATEDAKLRLEVNMQALKG 1574

Query: 1069 AETDEIKILLEESRAQQKETLKSLLEQETE----------------NLRTEISKLNQKIQ 1112
                +++   E++  ++++  + L E ETE                 L  ++  L  +  
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634

Query: 1113 DNNENYQVGLAELRTLMTIEKD------------QCISELISRHEEESNILKAELNKVTS 1160
               +  +  + +LR L    KD              I      +E+++  L+A+L ++  
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1694

Query: 1161 LHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEK------ITQQEEKYEAIIQNLEK 1214
                A    K    +  EL  +L S LS     +DEK      I Q EE+ E    N+E 
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754

Query: 1215 DRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKS 1274
               + V    Q  EQL  +L  E+  A +      +LER+   KEL  K+  +E  +   
Sbjct: 1755 MSDR-VRKATQQAEQLSNELATERSTAQKNESARQQLERQ--NKELRSKLHEMEGAVKSK 1811

Query: 1275 PAIDSTRGDSSSLVAELQEKLQE---EKAKFLEQLEEQEKRKNEEMQNVRTS-LIAEQQT 1330
                ST     + +A+L+E++++   EK    + L++++K+  E +  V     +AEQ  
Sbjct: 1812 --FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY- 1868

Query: 1331 NFNTVLTREKMRKENI-INDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEV 1389
                   +E+  K N  +  L  +L+   ++ +R       L  +     E  + +  EV
Sbjct: 1869 -------KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1921

Query: 1390 SKLRSSSFVPSP 1401
            + L+S    P P
Sbjct: 1922 NALKSKLRGPPP 1933



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 94/414 (22%), Positives = 178/414 (42%), Gaps = 32/414 (7%)

Query: 1103 EISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLH 1162
            E+     ++Q   E  Q    EL+ L     +Q  S+L     EE N+L+ +L   T L+
Sbjct: 853  EMQAKEDELQKTKERQQKAENELKEL-----EQKHSQLT----EEKNLLQEQLQAETELY 903

Query: 1163 NQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSS 1222
             +A E+   L  +  EL+  L    + LE ++D     Q E+ +   Q L+ + Q  +  
Sbjct: 904  AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ--LEE 961

Query: 1223 QEQDREQL-IQKLNCE------KDEAIQTALKEFKL--EREVVEKELLEKVKHLENQIAK 1273
            +E  R++L ++K+  E      +DE +    +  KL  ER+++E+ + +   +L  +  K
Sbjct: 962  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021

Query: 1274 SPAIDSTRGDSSSLVAEL------QEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSL--I 1325
            +  +   +    S+++EL      +EK ++E  K   +LE      +E++ +++  +  +
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081

Query: 1326 AEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRA---RLLEEK 1382
              Q       L     R ++ I   ++ LK   + +    DL E L  +RA   +  ++K
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141

Query: 1383 KKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVET-ADEGRVDSAMETS 1441
            + L EE+  L++         AT  EL      E+         ET + E +V    +  
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201

Query: 1442 MMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEK 1495
              +V+E    L + K+    L++  Q  E+EN  L   L     +     H +K
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 34/163 (20%), Positives = 72/163 (44%), Gaps = 20/163 (12%)

Query: 1342 RKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSP 1401
            R+E  +    D+L+ T ++Q++ ++ ++ L +  ++L EEK  L+E++            
Sbjct: 849  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ----------- 897

Query: 1402 YVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRI-- 1459
                  ELY     E      R A +  +   +   ME  +   ++    L  E++++  
Sbjct: 898  ---AETELYA----EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ 950

Query: 1460 MLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEKIAIRDFQ 1502
             +L+   QL+EEE  R   +L   +  +   +  ++I + D Q
Sbjct: 951  QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993


>gi|19924131 RAD50 homolog isoform 2 [Homo sapiens]
          Length = 1173

 Score =  108 bits (269), Expect = 5e-23
 Identities = 166/779 (21%), Positives = 313/779 (40%), Gaps = 138/779 (17%)

Query: 798  LERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEI 857
            LE  R V Q     ++  + +L + + + +K            A EIR+         +I
Sbjct: 50   LETLRQVRQTQGQKVKEYQMELKYLKQYKEK------------ACEIRD---------QI 88

Query: 858  TLKEKHQKELLSLKNEYEGKLDGL---IKETEENENKIKKLKGELVCL------------ 902
            T KE        +   YE +LD L   +KE E N +KI KL  E+  L            
Sbjct: 89   TSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNS 148

Query: 903  ------EEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSRE 956
                  E+V Q  D +   + H  +  +    EK++KL++    +   N E + L Q + 
Sbjct: 149  ELEEKMEKVFQGTDEQLNDLYHNHQRTV---REKERKLVDCHRELEKLNKESRLLNQEKS 205

Query: 957  IVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELE------DTLQVRHIQEFEKVMTDH 1010
             +L +  +L ++ D   + +RA   SL QS   +LE           R I+ F K++ + 
Sbjct: 206  ELLVEQGRLQLQADRHQEHIRAR-DSLIQSLATQLELDGFERGPFSERQIKNFHKLVRER 264

Query: 1011 R--------------VSLEELK-------KENQQIINQIQESHAEIIQEKEKQLQELKLK 1049
            +                 E LK       ++ +  + +I E  +EI+ +K+ +L+ +K +
Sbjct: 265  QEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYE 324

Query: 1050 VSDL---SDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKS---LLEQETENLRTE 1103
            +  L   SD   +L+ EL   E E      L +  +    ETLK     L+ E  +L   
Sbjct: 325  LQQLEGSSDRILELDQELIKAERE------LSKAEKNSNVETLKMEVISLQNEKADLDRT 378

Query: 1104 ISKLNQKIQDNNENYQVGL-AELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLH 1162
            + KL+Q+++  N +       E+ T    +KD+ I ++ SRH +E   L         L 
Sbjct: 379  LRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLE 438

Query: 1163 NQAFEIEKNLKEQIIELQSKLDSELSALE----------RQKDEKITQQEEKYEAII--Q 1210
            +      K +  Q  +  +KL+ EL++ E          ++K+E+++  E+K   +   Q
Sbjct: 439  DWLHSKSKEI-NQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQ 497

Query: 1211 NLEKDRQKLVSSQEQDRE-------------QLIQKLNCEKDEAIQTALKEFKLEREVVE 1257
            + E D  +L    E+  +             Q I +L  E         + F+ E E+ E
Sbjct: 498  DFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQE 557

Query: 1258 ---------KELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEE 1308
                     +   +K+K  E+++ K       R D    +  +++ + + K K + +L  
Sbjct: 558  VISDLQSKLRLAPDKLKSTESELKKK----EKRRDEMLGLVPMRQSIIDLKEKEIPELRN 613

Query: 1309 QEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRK---------ENIINDLSDKLKSTMQ 1359
            + +  N ++Q ++   I EQ+T   T++  E+  K         E    +L D  +   Q
Sbjct: 614  KLQNVNRDIQRLKND-IEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQ 672

Query: 1360 QQERDK--DLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPEL 1417
            Q  + +  DL  ++ +      E++ KL+   SK+  +  +          L  +   EL
Sbjct: 673  QAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHL-KSTTNEL 731

Query: 1418 PGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRL 1476
              E  + +       +++         VQ     + + K+++  LE TL+  ++E + L
Sbjct: 732  KSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEEL 790



 Score = 87.8 bits (216), Expect = 8e-17
 Identities = 134/618 (21%), Positives = 269/618 (43%), Gaps = 102/618 (16%)

Query: 849  EKVKCSLEITLKEKHQK------ELLSLKNEYEGKLDGLIKETEENENKIKK---LKGEL 899
            E +K   E++  EK+        E++SL+NE +  LD  +++ ++   ++      + ++
Sbjct: 341  ELIKAERELSKAEKNSNVETLKMEVISLQNE-KADLDRTLRKLDQEMEQLNHHTTTRTQM 399

Query: 900  VCLEEVLQNKDNEFALVK--HEKEAVICLQNEKDQKLLEMENIMHSQNCEIKEL-----K 952
              L +   +KD +   +K  H  E    L    ++K  ++E+ +HS++ EI +      K
Sbjct: 400  EMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKK--QLEDWLHSKSKEINQTRDRLAK 457

Query: 953  QSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTL-QVRHIQEFEKVMTDHR 1011
             ++E+   +  K H+ N+ K +          +  L   ED L  V   Q+FE  +   +
Sbjct: 458  LNKELASSEQNKNHINNELKRK----------EEQLSSYEDKLFDVCGSQDFESDLDRLK 507

Query: 1012 VSLEELKKEN----------QQIINQIQESH------AEIIQEKEKQLQE----LKLKVS 1051
              +E+  K+            Q I Q+ + +       + + + E +LQE    L+ K+ 
Sbjct: 508  EEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLR 567

Query: 1052 DLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKI 1111
               D     E EL  KE   DE+  L+       ++++  L E+E   LR ++  +N+ I
Sbjct: 568  LAPDKLKSTESELKKKEKRRDEMLGLVP-----MRQSIIDLKEKEIPELRNKLQNVNRDI 622

Query: 1112 QDNNENYQVGLAELRTLMTIEKDQ--CISE--LISRHEEESNILKAELNKVTSLHNQAFE 1167
            Q    + +     L T+M  E+    C+++  ++ R + E   ++ ++ +  +   Q  +
Sbjct: 623  QRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAA-KLQGID 681

Query: 1168 IEKNLKE---QIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQE 1224
            +++ +++   +  E Q KLD+  S +E  +     QQE+         E   +KL  S  
Sbjct: 682  LDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN 741

Query: 1225 QDREQLIQKLNCEKDEAIQTALKEFK------------LEREVVEKELLEKVKHLENQIA 1272
              R Q +++   E    +Q+  +E K            LE+   EKE L   K+  N+IA
Sbjct: 742  LQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIA 801

Query: 1273 ---------KSPAIDSTRGDSSSLVAELQEKLQEEKA----KFLEQLEEQEKRK---NEE 1316
                     K   I     D  + + + ++  +++K     K + QL E EK K   NE+
Sbjct: 802  QDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINED 861

Query: 1317 MQNVRTSLIAEQQTNFNTVLTREKMRKENI-INDLSDKLKSTMQQQERDKDLIESLSEDR 1375
            M+ +R  +        +T   +E+  ++N+ +   +++LK    ++ER + L E      
Sbjct: 862  MRLMRQDI--------DTQKIQERWLQDNLTLRKRNEELKEV--EEERKQHLKEMGQMQV 911

Query: 1376 ARLLEEKKKLEEEVSKLR 1393
             ++  E +KLEE +  ++
Sbjct: 912  LQMKSEHQKLEENIDNIK 929



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 138/678 (20%), Positives = 288/678 (42%), Gaps = 110/678 (16%)

Query: 911  NEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVEND 970
            N   LV+  +E      N+      E E +   Q  EI++ K     ++E   ++  +  
Sbjct: 256  NFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQ 315

Query: 971  EKLQLLRAELQSLEQSHLKELE-DTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQ 1029
             +L+ ++ ELQ LE S  + LE D   ++  +E  K   +   ++E LK E    +  +Q
Sbjct: 316  NELKNVKYELQQLEGSSDRILELDQELIKAERELSK--AEKNSNVETLKME----VISLQ 369

Query: 1030 ESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETL 1089
               A++ +   K  QE++ +++  + TR ++E+ L   +A+ DE    + + +++  + L
Sbjct: 370  NEKADLDRTLRKLDQEME-QLNHHTTTRTQMEM-LTKDKADKDE---QIRKIKSRHSDEL 424

Query: 1090 KSLL----------------EQETENLRTEISKLNQKIQDNNENYQVGLAELR----TLM 1129
             SLL                 +E    R  ++KLN+++  + +N      EL+     L 
Sbjct: 425  TSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLS 484

Query: 1130 TIEK---DQCIS-------ELISRHEEESNILKAELNKVTSLHNQ--------------- 1164
            + E    D C S       + +    E+S+  +A L   T++++Q               
Sbjct: 485  SYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPV 544

Query: 1165 ---AFEIEKNLKEQIIELQSKL----------DSELSALERQKDEKITQQEEKYEAI--- 1208
                F+ E  L+E I +LQSKL          +SEL   E+++DE +     +   I   
Sbjct: 545  CQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLK 604

Query: 1209 ----------IQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEA-----IQTALKEFKLER 1253
                      +QN+ +D Q+L +  E ++E L+  +  E++ A       T ++ F++E 
Sbjct: 605  EKEIPELRNKLQNVNRDIQRLKNDIE-EQETLLGTIMPEEESAKVCLTDVTIMERFQMEL 663

Query: 1254 EVVEKELLEKVKHLE--------NQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQ 1305
            + VE+++ ++   L+         Q+ +       + D+ S   EL  KL +++ + ++ 
Sbjct: 664  KDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQH 723

Query: 1306 LEEQEKRKNEEMQNVRTSLIAEQQTNFNTV-LTREKMRKENIINDLSDK---LKSTMQQQ 1361
            L+        E   + T+L   QQ    TV L+ E       I D  ++   L++T+++ 
Sbjct: 724  LKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKF 783

Query: 1362 ERDKDLIESLSEDRARLLEEK-KKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGE 1420
            +++K+ + +      ++ ++K   ++E+V  +         Y+    + Y     +   E
Sbjct: 784  QQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDY---KKQKETE 840

Query: 1421 SDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQ----RIMLLERTLQLKEEENKRL 1476
             ++   + ++  +    +   M  ++++I     +++     + L +R  +LKE E +R 
Sbjct: 841  LNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEER- 899

Query: 1477 NQRLMSQSMSSVSSRHSE 1494
             Q L       V    SE
Sbjct: 900  KQHLKEMGQMQVLQMKSE 917



 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 114/572 (19%), Positives = 240/572 (41%), Gaps = 71/572 (12%)

Query: 946  CEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEK 1005
            CEI++   S+E  L   K++    + +L  L+  L+ +E +  K ++   +++ +   +K
Sbjct: 82   CEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKK 141

Query: 1006 VMTDHRVSLEELKKE----NQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLE 1061
             M      LEE  ++      + +N +  +H   ++EKE++L +            C  E
Sbjct: 142  QMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVD------------CHRE 189

Query: 1062 VELALKEA---ETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQ-KIQDNNEN 1117
            +E   KE+     ++ ++L+E+ R Q +       ++  E++R   S +     Q   + 
Sbjct: 190  LEKLNKESRLLNQEKSELLVEQGRLQLQ------ADRHQEHIRARDSLIQSLATQLELDG 243

Query: 1118 YQVGLAELRTLMTIEKDQCISELISRHEEESNILKAEL-NKVTSLHNQAFEI--EKNLKE 1174
            ++ G    R +    K   + E      + +N L  +   K T    Q  EI  +K    
Sbjct: 244  FERGPFSERQIKNFHK--LVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLG 301

Query: 1175 QIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKL 1234
            +IIEL+S++ S+     +    ++ Q E   + I   LE D++ + + +E  + +    +
Sbjct: 302  RIIELKSEILSKKQNELKNVKYELQQLEGSSDRI---LELDQELIKAERELSKAEKNSNV 358

Query: 1235 NCEKDEAIQTALKEFKLEREVVE-KELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQE 1293
               K E I    ++  L+R + +  + +E++ H      +   +   + D    + +++ 
Sbjct: 359  ETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKS 418

Query: 1294 KLQEEKAKFL------EQLEEQEKRKNEEMQNVRTSL------IAEQQTNFNTVLTREKM 1341
            +  +E    L      +QLE+    K++E+   R  L      +A  + N N +   E  
Sbjct: 419  RHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHI-NNELK 477

Query: 1342 RKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSP 1401
            RKE  ++   DKL      Q+ + DL         RL EE +K  ++ + L  ++ V S 
Sbjct: 478  RKEEQLSSYEDKLFDVCGSQDFESDL--------DRLKEEIEKSSKQRAMLAGATAVYSQ 529

Query: 1402 YVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENI-----HMLSEEK 1456
            ++    +   +C P       R     A+   V S +++ +    + +      +  +EK
Sbjct: 530  FITQLTDENQSCCP----VCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEK 585

Query: 1457 QR------IMLLERTLQLKEEENKRLNQRLMS 1482
            +R      + + +  + LKE+E   L  +L +
Sbjct: 586  RRDEMLGLVPMRQSIIDLKEKEIPELRNKLQN 617



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 111/547 (20%), Positives = 246/547 (44%), Gaps = 71/547 (12%)

Query: 859  LKEKHQKELLSL------KNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNE 912
            +K +H  EL SL      K + E  L    KE  +  +++ KL  EL   E+   + +NE
Sbjct: 416  IKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNE 475

Query: 913  FALVKHEKEAV------ICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLH 966
                + +  +       +C   + +  L  ++  +   + +   L  +  +  + + +L 
Sbjct: 476  LKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLT 535

Query: 967  VENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVM-TDHRVSLEELKKENQQII 1025
             EN     + +   Q+  ++ L+E+   LQ +     +K+  T+  +  +E +++    +
Sbjct: 536  DENQSCCPVCQRVFQT--EAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGL 593

Query: 1026 NQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQ 1085
              +++S   II  KEK++ EL+ K+ +++    +L+ ++  +E ET    I+ EE  A+ 
Sbjct: 594  VPMRQS---IIDLKEKEIPELRNKLQNVNRDIQRLKNDI--EEQETLLGTIMPEEESAKV 648

Query: 1086 KETLKSLLEQ---ETENLRTEISK---------LNQKIQDNNENYQVGLAELRTLMTIEK 1133
              T  +++E+   E +++  +I++         L++ +Q  N+  Q    +L T+ +  K
Sbjct: 649  CLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSS--K 706

Query: 1134 DQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNL--KEQIIELQSKLDSELSALE 1191
             +   +LI   +E+   LK+  N++ S   +  +I  NL  ++Q+ E   +L +E+ +L 
Sbjct: 707  IELNRKLIQDQQEQIQHLKSTTNELKS---EKLQISTNLQRRQQLEEQTVELSTEVQSLY 763

Query: 1192 RQ-KDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEA--------- 1241
            R+ KD K  +Q    E  ++  ++++++L++ +    +    KLN  K++          
Sbjct: 764  REIKDAK--EQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKD 821

Query: 1242 ----IQTALKEFKLEREVVEKELLEKVKHLENQIAK--------SPAIDSTRGDSSSLVA 1289
                IQ    ++K ++E    +++ ++   E    K           ID+ +     L  
Sbjct: 822  IENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQD 881

Query: 1290 ELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSL--------IAEQQTNFNTVLTREKM 1341
             L  + + E+ K +E+  +Q  ++  +MQ ++           I   + N N  L R+K 
Sbjct: 882  NLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKG 941

Query: 1342 RKENIIN 1348
             +E II+
Sbjct: 942  YEEEIIH 948



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 109/539 (20%), Positives = 232/539 (43%), Gaps = 91/539 (16%)

Query: 781  NVCGKEDF-GDHTSLNVQLERCR--------VVAQDSHFSIQTIKED--LCHFRTFVQKE 829
            +VCG +DF  D   L  ++E+            A  S F  Q   E+   C     V + 
Sbjct: 492  DVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQT 551

Query: 830  QCDFSNSLKCTAVEIRNIIEKVKCS-LEITLKEKHQKELLSLKNEYEGKLDGLIKETEEN 888
            + +    +     ++R   +K+K +  E+  KEK + E+L L    +  +D   KE  E 
Sbjct: 552  EAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPEL 611

Query: 889  ENKIKKLKGELVCLEEVLQNKDNEFALVKHEKE-AVICLQN------------EKDQKL- 934
             NK++ +  ++  L+  ++ ++     +  E+E A +CL +            + ++K+ 
Sbjct: 612  RNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIA 671

Query: 935  --------LEMENIMHSQNCEIKELKQSREIV---LEDLKKLHVENDEKLQLLRAELQSL 983
                    ++++  +   N E +E +   + V   +E  +KL  +  E++Q L++    L
Sbjct: 672  QQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNEL 731

Query: 984  EQSHLK----------------ELEDTLQ--VRHIQEFEKVMTDHRVSLEELKKENQQII 1025
            +   L+                EL   +Q   R I++ ++ ++    +LE+ ++E +++I
Sbjct: 732  KSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELI 791

Query: 1026 NQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELA------LKEAETDEIKILLE 1079
            N+   S+ +I Q+K   L ++K KV ++      +E  +        K+ ET+  K++ +
Sbjct: 792  NKKNTSN-KIAQDK---LNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQ 847

Query: 1080 ESRAQQKETLKSLLEQETENLRTEISKLNQKIQD----NNENYQVGLAELRTLMTIEKDQ 1135
             S  ++    K  + ++   +R +I    QKIQ+    +N   +    EL+ +   E+ Q
Sbjct: 848  LSECEKH---KEKINEDMRLMRQDID--TQKIQERWLQDNLTLRKRNEELKEVEE-ERKQ 901

Query: 1136 CISEL----ISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALE 1191
             + E+    + + + E   L+  ++ +   HN A   +K  +E+II  + +L        
Sbjct: 902  HLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKEL-------- 953

Query: 1192 RQKDEKITQQEEKYE--AIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKE 1248
              ++ +    EEKY    I+    +   K +    +  +Q I K +  K E I   +++
Sbjct: 954  --REPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRD 1010


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  107 bits (266), Expect = 1e-22
 Identities = 148/690 (21%), Positives = 305/690 (44%), Gaps = 87/690 (12%)

Query: 848  IEKVKCSLE---ITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEE 904
            +EK +  LE   + ++E+ QK  L+++ E   +L+   K+ E   N ++    EL   ++
Sbjct: 1482 LEKCRSVLEHLPMAVQEREQK--LTVQREQIRELE---KDRETQRNVLEHQLLELEKKDQ 1536

Query: 905  VLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCE---IKELKQSREIVLED 961
            +++++  +   +K +   + CL        LE+E   H   C+   IKEL+  RE     
Sbjct: 1537 MIESQRGQVQDLKKQLVTLECLA-------LELEENHHKMECQQKLIKELEGQRETQRVA 1589

Query: 962  LKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKEN 1021
            L  L ++ +E+ Q L+A+     Q H  E   T+  R +QE ++ +   R  +EEL+++ 
Sbjct: 1590 LTHLTLDLEERSQELQAQSS---QIHDLESHSTVLARELQERDQEVKSQREQIEELQRQK 1646

Query: 1022 QQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEES 1081
            + +   ++    E++ +KE+        +  L D R +   +  + E + ++IK+ L E 
Sbjct: 1647 EHLTQDLERRDQELMLQKER--------IQVLEDQRTR---QTKILEEDLEQIKLSLRE- 1694

Query: 1082 RAQQKETLKSLLEQETEN-------LRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKD 1134
            R ++  T + L+++  E         R  +  +   ++D  +  +     +  L  + KD
Sbjct: 1695 RGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQEL-KD 1753

Query: 1135 QCISELISRHE---EESNILKAELNKVTSLHNQAFEI-------EKNLKEQIIELQSKL- 1183
            Q   +L   H    E S +L     ++  L  Q  E        E++L+ Q+ E Q  L 
Sbjct: 1754 QLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALA 1813

Query: 1184 --DSELSALERQKDEKITQQE---EKYEAIIQNLE------KDRQKLVSSQEQDREQLIQ 1232
              D EL AL++++ +   Q+E   EK +A+   LE      K+R   +   ++   +L +
Sbjct: 1814 QRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEE 1873

Query: 1233 KLNCE--KDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAE 1290
            +L  E  + +A++  L + + E    EK LL   +    Q A+   +++     S L A+
Sbjct: 1874 ELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQ-AQEHEVETRALQDSWLQAQ 1932

Query: 1291 LQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIIN-- 1348
               K ++++ + L + E Q  R  EE    R   + E     +  L   + ++++++   
Sbjct: 1933 AVLKERDQELEAL-RAESQSSRHQEEAARARAEALQEALGKAHAAL---QGKEQHLLEQA 1988

Query: 1349 DLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPE 1408
            +LS  L+++    +   D  ++     +R LEE  +++E   +++         V    +
Sbjct: 1989 ELSRSLEASTATLQASLDACQA----HSRQLEEALRIQE--GEIQDQDLRYQEDVQQLQQ 2042

Query: 1409 LYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEK------QRIMLL 1462
                   EL  + +R   E   E  +   ++ +M+  ++N+    EE+      Q +  L
Sbjct: 2043 ALAQRDEELRHQQER---EQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVREL 2099

Query: 1463 ERTLQLKEEENKRLNQRLMSQSMSSVSSRH 1492
            + TL  KE+E   L +     ++ ++   H
Sbjct: 2100 QLTLAQKEQEILELRETQQRNNLEALPHSH 2129



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 153/644 (23%), Positives = 288/644 (44%), Gaps = 81/644 (12%)

Query: 883  KETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMH 942
            +  EE +   K  +G L  ++ +L++K+ E   V+ ++E +  LQ  KDQ   +++ + H
Sbjct: 1708 ERAEEGKGPSKAQRGSLEHMKLILRDKEKE---VECQQEHIHELQELKDQLEQQLQGL-H 1763

Query: 943  SQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSL-EQSHLKELEDTLQVRHIQ 1001
             +  E   L   RE              +++ +L+ +LQ   EQ  LKE   +LQ + + 
Sbjct: 1764 RKVGETSLLLSQRE--------------QEIVVLQQQLQEAREQGELKE--QSLQSQ-LD 1806

Query: 1002 EFEKVMTDHRVSLEELKKENQQIINQIQ--ESHAEIIQEKEKQ----LQELKLKVSDLSD 1055
            E ++ +      LE L++E QQ   Q +  +  A+ +Q   +Q    L+E   ++ D  +
Sbjct: 1807 EAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKE 1866

Query: 1056 TRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLL--EQETENLRTEISKLNQKIQD 1113
               +LE ELA++      ++ +L + RA+ +E  K+LL  +Q+      E     + +QD
Sbjct: 1867 QARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQD 1926

Query: 1114 NNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAEL--NKVTSLHNQAFEIEKN 1171
            +    Q  L E    +   + +  S   SRH+EE+   +AE     +   H      E++
Sbjct: 1927 SWLQAQAVLKERDQELEALRAESQS---SRHQEEAARARAEALQEALGKAHAALQGKEQH 1983

Query: 1172 LKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAI-IQNLEKDRQKLVSSQEQDREQL 1230
            L EQ  EL   L++  + L+   D       +  EA+ IQ  E   Q L    ++D +QL
Sbjct: 1984 LLEQA-ELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL--RYQEDVQQL 2040

Query: 1231 IQKLNCEKDEAIQTALKEFKLERE-VVEKELLEKVKHLENQIAKSPAIDSTRGDSS---- 1285
             Q L  ++DE ++      + ERE ++EK L ++V+  EN I +   +   R +      
Sbjct: 2041 QQAL-AQRDEELR-----HQQEREQLLEKSLAQRVQ--ENMIQEKQNLGQEREEEEIRGL 2092

Query: 1286 -SLVAELQEKLQEEKAKFLEQLEEQEKRKNEEM-QNVRTSLIAEQQTNFNTVLTREKMRK 1343
               V ELQ  L +++ + LE  E Q++   E +  + +TS + EQ    +++  R +   
Sbjct: 2093 HQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQREL 2152

Query: 1344 ENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLL-----------------EEKKKLE 1386
            E +   L       ++ +E+ +DL  SL++ +A +                   E+++L+
Sbjct: 2153 ERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQ 2212

Query: 1387 EEVSKLR---SSSFVPSPYVATAPEL--YGACAPELPGESDRSAVETADEGRVDSAMETS 1441
            +E+   R       + SP   +  EL   G    +L GE      E + +G    +    
Sbjct: 2213 DELELTRRALEKERLHSPGATSTAELGSRGEQGVQL-GEVSGVEAEPSPDGMEKQSWRQR 2271

Query: 1442 MMSVQENIHMLSEEKQRI----MLLERTLQLKEEENKRLNQRLM 1481
            +  +Q+ +  L  ++ R+    + L  TL+  E E ++L +  M
Sbjct: 2272 LEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAM 2315



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 148/752 (19%), Positives = 324/752 (43%), Gaps = 98/752 (13%)

Query: 794  LNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKC 853
            L VQ++      +     ++ +K +L   R+  ++E+   +  L     E +  +E+ K 
Sbjct: 790  LEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKA 849

Query: 854  SLEIT---LKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKD 910
            + E     L+EK +KE    + E    L+ L +E  E E ++K+ + E+   E +   ++
Sbjct: 850  AHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEM---EAIQAQRE 906

Query: 911  NEFALVKHEKEAVIC---LQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHV 967
             E    + + E+ +C   L+ EK++  L +E ++ +Q  E+ +  Q  E + +D+K   +
Sbjct: 907  EE----RTQAESALCQMQLETEKERVSL-LETLLQTQK-ELADASQQLERLRQDMKVQKL 960

Query: 968  ENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQ 1027
            +  E   +L+ +LQ  ++                            L+E  ++++  +  
Sbjct: 961  KEQETTGILQTQLQEAQRE---------------------------LKEAARQHRDDLAA 993

Query: 1028 IQESHAEIIQEK---EKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQ 1084
            +QE  + ++Q+K   +KQ+++LK ++    D++  +E E+  K  ET E   + +E   +
Sbjct: 994  LQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELERE 1053

Query: 1085 QKETLKSLLE--------QETENLR-TEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQ 1135
            +     SL+E        QE +++R  E+S L Q +Q+     +   A++  L    K  
Sbjct: 1054 KASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVK-- 1111

Query: 1136 CISELISRHEEESNILKAE---LNKVTSLHNQAFEIEKNL---KEQIIELQSKLDSELSA 1189
                     E+E++ L  E   L ++ + H    ++  +L   + +  +LQ +L S  S 
Sbjct: 1112 ---------EKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQ 1162

Query: 1190 LERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLI-------QKLNCEKDE-A 1241
            LE    E+    + + +A + +L    Q+ + S  + R +L             E D+  
Sbjct: 1163 LEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNG 1222

Query: 1242 IQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAK 1301
             ++  K   L   +  + +   +  L   + K+     TR      V +L+E+L + +A+
Sbjct: 1223 ARSLFKRGPLLTALSAEAVASALHKLHQDLWKT---QQTRDVLRDQVQKLEERLTDTEAE 1279

Query: 1302 FLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQ 1361
              +   E +  + +  QN       E + N    L  E M     +  L  +L+    Q+
Sbjct: 1280 KSQVHTELQDLQRQLSQNQEEKSKWEGKQN---SLESELMELHETMASLQSRLRRAELQR 1336

Query: 1362 ---ERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELP 1418
               + +++L+++  E+    +E  +    E     S++ +    + TA         E+ 
Sbjct: 1337 MEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVE 1396

Query: 1419 GESDRSAVETADEGRVDSAMETSMMSVQENIHM----LSEEKQRIMLLERTLQLKEEENK 1474
             E +R A    ++G +  A   ++   QEN+ +    L+E ++ +  L    Q++E E +
Sbjct: 1397 SERER-AQALQEQGELKVAQGKAL---QENLALLTQTLAEREEEVETLRG--QIQELEKQ 1450

Query: 1475 RLNQRLMSQSMSSVSSRHSEKIAIRDFQVGDL 1506
            R  Q+   + +S    + ++++ ++  Q+ +L
Sbjct: 1451 REMQKAALELLSLDLKKRNQEVDLQQEQIQEL 1482



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 170/793 (21%), Positives = 327/793 (41%), Gaps = 126/793 (15%)

Query: 785  KEDFGDHTSLNVQLERCRVVAQDS--HFSIQTIKEDLCHFRTFVQ--KEQCDFSNSLKCT 840
            KE   +  ++  Q E  R  A+ +     ++T KE +    T +Q  KE  D S  L+  
Sbjct: 892  KEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERL 951

Query: 841  A--VEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETE-------ENENK 891
               ++++ + E+    +  T  ++ Q+EL     ++   L  L +E+        + + +
Sbjct: 952  RQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQ 1011

Query: 892  IKKLKGELVC-------LEEVLQNKDNEFAL-------VKHEKEAVICLQNEKDQKLLEM 937
            ++ LK +LV        +E+ +Q K  E          ++ EK ++     EK+Q+LL +
Sbjct: 1012 VEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVL 1071

Query: 938  ENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKE---LEDT 994
            +     +  E+  L+Q  +    + K+L  +    ++LLR E++  E   L +   L + 
Sbjct: 1072 QEADSIRQQELSALRQDMQEAQGEQKELSAQ----MELLRQEVKEKEADFLAQEAQLLEE 1127

Query: 995  LQVRHIQEFEKVMTDHRVSL--EELKKENQQIINQIQESHAEIIQEKEK---------QL 1043
            L+  HI E +      R SL  +E K    Q+  +  ES  E +  +++         QL
Sbjct: 1128 LEASHITEQQL-----RASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQL 1182

Query: 1044 QELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKS--LLEQETENLR 1101
              L   +     + C+   EL+        +  L  +    +    +   L     E + 
Sbjct: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242

Query: 1102 TEISKLNQKIQDNNENYQV------GLAELRTLMTIEKDQCISEL------ISRHEEESN 1149
            + + KL+Q +    +   V       L E  T    EK Q  +EL      +S+++EE +
Sbjct: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS 1302

Query: 1150 ILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLD-SELSALERQKDEKITQQEEKYEAI 1208
              + + N   SL ++  E    L E +  LQS+L  +EL  +E Q + ++ Q      A 
Sbjct: 1303 KWEGKQN---SLESELME----LHETMASLQSRLRRAELQRMEAQGERELLQ------AA 1349

Query: 1209 IQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLE 1268
             +NL    + L ++  + R Q       E+D  ++TA    KL+ E VE E  E+ + L+
Sbjct: 1350 KENLTAQVEHLQAAVVEARAQASAAGILEED--LRTARSALKLKNEEVESER-ERAQALQ 1406

Query: 1269 NQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIA-- 1326
             Q     A      ++ +L+ +   + +EE      Q++E EK++  EMQ     L++  
Sbjct: 1407 EQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQR--EMQKAALELLSLD 1464

Query: 1327 EQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQER----DKDLIESLSEDRARLLEEK 1382
             ++ N    L +E++++      + + L   +Q++E+     ++ I  L +DR     ++
Sbjct: 1465 LKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRE---TQR 1521

Query: 1383 KKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSM 1442
              LE ++ +L     +                     ES R  V+   +  V   +E   
Sbjct: 1522 NVLEHQLLELEKKDQMI--------------------ESQRGQVQDLKKQLV--TLECLA 1559

Query: 1443 MSVQENIHML------------SEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSS 1490
            + ++EN H +              E QR+ L   TL L+E   +   Q      + S S+
Sbjct: 1560 LELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHST 1619

Query: 1491 RHSEKIAIRDFQV 1503
              + ++  RD +V
Sbjct: 1620 VLARELQERDQEV 1632



 Score = 81.3 bits (199), Expect = 7e-15
 Identities = 126/598 (21%), Positives = 253/598 (42%), Gaps = 115/598 (19%)

Query: 791  HTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEK 850
            +T L  QL++      +    ++ I+E+    +  +QK+  +  +  +    ++  + ++
Sbjct: 661  NTHLEAQLQKAEEAGAELQADLRDIQEE----KEEIQKKLSESRHQQEAATTQLEQLHQE 716

Query: 851  VKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKD 910
             K   E+  +   +KE              L++E    E +++ ++ +   L E LQ   
Sbjct: 717  AKRQEEVLARAVQEKE-------------ALVREKAALEVRLQAVERDRQDLAEQLQG-- 761

Query: 911  NEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVEND 970
                 +   KE +     E  Q+   +E        +I+ + Q++E++  +++ L +E D
Sbjct: 762  -----LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELD 816

Query: 971  EKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQE 1030
                         E+S  ++  D    R + + E+   + + +LE+ K  +++ +NQ++E
Sbjct: 817  ------------TERSQAEQERDA-AARQLAQAEQ---EGKTALEQQKAAHEKEVNQLRE 860

Query: 1031 SHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAET--DEIKILLEESRAQ---- 1084
                   EKE+   + +L  +  S  R K+E+E+ LKE +T  + I+   EE R Q    
Sbjct: 861  K-----WEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESA 915

Query: 1085 ----QKETLK---SLLE-------------QETENLRTEISKLNQKIQDNNENYQVGLAE 1124
                Q ET K   SLLE             Q+ E LR ++     K Q+     Q  L E
Sbjct: 916  LCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQE 975

Query: 1125 LRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKL- 1183
             +  +     Q   +L +  EE S++L+ ++               +L++Q+ +L+S+L 
Sbjct: 976  AQRELKEAARQHRDDLAALQEESSSLLQDKM---------------DLQKQVEDLKSQLV 1020

Query: 1184 --DSELSALERQKDEKITQQEEKYEAIIQNLEKDR-----------QKLVSSQEQD--RE 1228
              D     +E++  EK+ + +E Y  I + LE+++           Q+L+  QE D  R+
Sbjct: 1021 AQDDSQRLVEQEVQEKLRETQE-YNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQ 1079

Query: 1229 QLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEK-----------VKHLENQIAKSPAI 1277
            Q +  L  +  EA Q   KE   + E++ +E+ EK           ++ LE        +
Sbjct: 1080 QELSALRQDMQEA-QGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQL 1138

Query: 1278 DSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTV 1335
             ++     +  A+LQ +L+  +++      EQ+     + Q    SL +  Q    +V
Sbjct: 1139 RASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSV 1196



 Score = 65.1 bits (157), Expect = 5e-10
 Identities = 119/564 (21%), Positives = 241/564 (42%), Gaps = 90/564 (15%)

Query: 972  KLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVS-----LEELKKENQ---Q 1023
            +L LL A+ Q LE+   +  ++ +Q++   + EK     RV+     L + +K+N+   +
Sbjct: 245  QLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEK 304

Query: 1024 IINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEES-R 1082
            +I  ++E+  EI++    +L E +  +S     R   E +L+L++   D  ++++EE   
Sbjct: 305  MIKALRET-VEILETNHTELMEHEASLS-----RNAQEEKLSLQQVIKDITQVMVEEGDN 358

Query: 1083 AQQKETLKSLLEQETEN---------------LRTEISKLNQKIQDNNENYQVGLAELRT 1127
              Q    ++ LE ++                 +R+ +++  Q +QD  +    G  E   
Sbjct: 359  IAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQL-AGCQEAVN 417

Query: 1128 LMTIEKDQCISELISRHEEESNILKAELNKVT----SLHNQAFEIEKNL------KEQII 1177
            L+  + DQ         EEE   L+  L K+T    +L  Q  +++  +      +E + 
Sbjct: 418  LLQQQHDQW--------EEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQ 469

Query: 1178 ELQSKLDSELSALER--------------QKDEKITQQEEKYEAI---IQNLEKDRQKLV 1220
            + + +L  +L  LE+              Q D    Q+EE+ E +   ++  E+ ++ L+
Sbjct: 470  KAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLM 529

Query: 1221 SSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDST 1280
              + +  E L + +       ++ AL+   LE E++ +E  E    L         + S+
Sbjct: 530  GLEAKQSESLSELI------TLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSS 583

Query: 1281 RGDSSSLVAELQ------EKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSL-IAEQQTNFN 1333
                 + VA+L+        L E  A     L +Q  +  EE Q+V + +  AEQ  N  
Sbjct: 584  ENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNAL 643

Query: 1334 TVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLR 1393
             V   E  ++   + + +  L++ +Q+ E   +    L  D   + EEK+++++++S+ R
Sbjct: 644  QVDLAEAEKRREALWEKNTHLEAQLQKAE---EAGAELQADLRDIQEEKEEIQKKLSESR 700

Query: 1394 SSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLS 1453
                       T  E     A        R+  E     R  +A+E  + +V+ +   L+
Sbjct: 701  HQ----QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLA 756

Query: 1454 EEKQRIM----LLERTLQLKEEEN 1473
            E+ Q +     LLE +L   +++N
Sbjct: 757  EQLQGLSSAKELLESSLFEAQQQN 780



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 83/367 (22%), Positives = 142/367 (38%), Gaps = 48/367 (13%)

Query: 1137 ISELISRHEEESNILK--AELNKVTSLH-NQAFEIEKNLKEQIIELQSKLDSELSALERQ 1193
            + EL+ R EEE    +  AE+N    LH  +A  + K L+E +     KL  + S    +
Sbjct: 96   LDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDV----EKLTVDWSRARDE 151

Query: 1194 KDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLER 1253
               K +Q + + E     L+ +  +L+S   +      ++   E   A    L E K E 
Sbjct: 152  LMRKESQWQMEQEFFKGYLKGEHGRLLSLWRE--VVTFRRHFLEMKSATDRDLMELKAEH 209

Query: 1254 EVVEKELLEKVKHLENQIAKSPAIDSTRGDSSS------LVAELQEKLQE--EKAKFLEQ 1305
              +   LL     L           S R D         L+A+ QE  +E  E+++ L Q
Sbjct: 210  VRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQ 269

Query: 1306 LEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDK 1365
            L+ Q   +  E+Q        ++ T  + +LT+ + + E    D    +K+        +
Sbjct: 270  LKSQGDLEKAELQ--------DRVTELSALLTQSQKQNE----DYEKMIKAL-------R 310

Query: 1366 DLIESLSEDRARLLEEKKKL-----EEEVSKLRSSSFVPSPYVATAPELYGACAPELPGE 1420
            + +E L  +   L+E +  L     EE++S  +    +    V     +      E   E
Sbjct: 311  ETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLE 370

Query: 1421 SDRSAVETADEGRVDSAMET-------SMMSVQENIHMLSEEKQRIMLLERTLQLKEEEN 1473
             D S     D    D A+            +VQ+    L+  ++ + LL++     EEE 
Sbjct: 371  LDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEG 430

Query: 1474 KRLNQRL 1480
            K L QRL
Sbjct: 431  KALRQRL 437


>gi|9910266 kinesin family member 15 [Homo sapiens]
          Length = 1388

 Score =  106 bits (264), Expect = 2e-22
 Identities = 155/632 (24%), Positives = 279/632 (44%), Gaps = 121/632 (19%)

Query: 862  KHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKE 921
            K Q+ELLS  N  E       K+ +E + K   LK E+  L  VL + D E + VK E  
Sbjct: 770  KQQEELLSQLNVLE-------KQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYS 822

Query: 922  AVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQ 981
            +    Q ++  KL E    MH Q  ++  L+   E +LE    L    D   ++++ E+ 
Sbjct: 823  SFKTNQEKEFNKLSERH--MHVQ-LQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEID 879

Query: 982  SLEQS--HLKELEDTLQ-----VRHIQEFEKVMTDH-RVSLEELKKENQQIINQIQESHA 1033
             L ++  + K+  +TL+     +  + E EK   +   +  EE K+ + + I ++ E+  
Sbjct: 880  QLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEA-- 937

Query: 1034 EIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLL 1093
             + QEK+K+  + + +++ +     KLE  L      T+++   LE+SR   K+ +  L+
Sbjct: 938  -VRQEKQKETAKCEQQMAKVQ----KLEESLLA----TEKVISSLEKSRDSDKKVVADLM 988

Query: 1094 EQETENLRTEISK-------LNQKIQDNNENYQVGLAELRTLMTIEKDQ----------- 1135
             Q  E LRT + +       L Q+++D N  Y   L +      + K Q           
Sbjct: 989  NQIQE-LRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETL 1047

Query: 1136 ---CISELISR--------HEEESNILKAELNKVTSLHNQAFEIEKNLKEQII-ELQSKL 1183
                +SE I R        H  E   +  E +K  S   Q+ + E   KE +I ELQ KL
Sbjct: 1048 RLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKL 1107

Query: 1184 DSELSALERQKDE---KITQQEEKYEAIIQNLEKDRQ---------KLVSSQEQD----- 1226
            + +   +E++K+E   K+ Q E   ++  ++ +  +          KL+ +QEQ+     
Sbjct: 1108 NQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGR 1167

Query: 1227 -----REQLIQKLNCEKDEAIQTA----LKEFKLERE---VVEKELLEKVKHLENQI--- 1271
                  E L+ KLN  +D  ++ A    +KE   E E   +  ++L+EK   L+ Q+   
Sbjct: 1168 ASKTSLEHLVTKLN--EDREVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDI 1225

Query: 1272 -AKSPAIDSTRGDSSSLVAELQEKLQEE--KAKFLEQL--------EEQEKRKNEEMQNV 1320
              +    D    D+  L  E +E ++E   K+K +E++        E Q    N+EM+ +
Sbjct: 1226 KRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECL 1285

Query: 1321 RTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDR----- 1375
            R +   E+     +   +EK +  + + ++ ++ + T Q+ E  +  +E L+E+      
Sbjct: 1286 RMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEENGKLVG 1345

Query: 1376 -----------ARLLEEKKKLEEEVSKLRSSS 1396
                        RL +E  +L EE  KLR+ +
Sbjct: 1346 HQNLHQKIQYVVRLKKENVRLAEETEKLRAEN 1377



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 172/784 (21%), Positives = 324/784 (41%), Gaps = 151/784 (19%)

Query: 822  FRTFVQKEQCDFSNS--LKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEG--- 876
            F    QKE C F+N+  LK   ++I+  +   K   E   KE  +K  L L++E +    
Sbjct: 567  FSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQEYE-EFKELTRKRQLELESELQSLQK 625

Query: 877  ---KLDGLIKETE----ENENKIKKLKGELVCL----EEVLQNKDNEFALVKHEKEAVIC 925
                L+ L++ T+    +  +++ K+  E + +     +  Q        +  E  +   
Sbjct: 626  ANLNLENLLEATKACKRQEVSQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGS 685

Query: 926  LQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQ 985
            L  + +  +L+ + +      E+ E  Q+ E + E+L+ +     E++  L+A+L   E 
Sbjct: 686  LYTQ-NSSILDNDILNEPVPPEMNE--QAFEAISEELRTVQ----EQMSALQAKLDEEEH 738

Query: 986  SHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQE 1045
             +LK     LQ +H+ + E     H   ++EL    +    + QE     +   EKQLQE
Sbjct: 739  KNLK-----LQ-QHVDKLEH----HSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQE 788

Query: 1046 LKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQ------ETEN 1099
             + K   L      L V L   + E   +K+     +  Q++    L E+      + +N
Sbjct: 789  TQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDN 848

Query: 1100 LRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVT 1159
            LR E    N+K+ ++    Q     L+ +M  E DQ +S  +   ++E+  LK++LN + 
Sbjct: 849  LRLE----NEKLLESKACLQDSYDNLQEIMKFEIDQ-LSRNLQNFKKENETLKSDLNNLM 903

Query: 1160 SLHNQAFEIEKNLKEQIIELQSKLDSELSALE--------RQKDEKITQQEEKYEAIIQN 1211
             L     E EK  +   + LQ + D E S+ E        RQ+ +K T + E+  A +Q 
Sbjct: 904  EL----LEAEKE-RNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQK 958

Query: 1212 LEKD---RQKLVSSQEQDRE----------QLIQKLN---CEKDEAIQTALKEFK----- 1250
            LE+     +K++SS E+ R+            IQ+L    CEK E I T  +E K     
Sbjct: 959  LEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCK 1018

Query: 1251 ---------------------------------LEREVVEKELLEKVKHLENQI------ 1271
                                             L  ++    L E + H   Q+      
Sbjct: 1019 YNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEA 1078

Query: 1272 --AKSPAIDSTRGD---SSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIA 1326
                S  + S + +     +L+ ELQ KL ++K + +EQ + +   K  ++++V  S   
Sbjct: 1079 SKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEE-VEQKKNEYNFKMRQLEHVMDSAAE 1137

Query: 1327 EQQT-----NFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDR----AR 1377
            + Q+     +F T L +    +E  I D     K++++       L+  L+EDR    A 
Sbjct: 1138 DPQSPKTPPHFQTHLAKLLETQEQEIED-GRASKTSLEH------LVTKLNEDREVKNAE 1190

Query: 1378 LLEEKKKLEE-EVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDS 1436
            +L  K++L E E  +L S   +   +      L      ++  + + S     D  ++ +
Sbjct: 1191 ILRMKEQLREMENLRLESQQLIEKNW------LLQGQLDDIKRQKENSDQNHPDNQQLKN 1244

Query: 1437 AMETSM---MSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRL-MSQSMSSVSSRH 1492
              E S+   ++  + +  + + K  +  ++  L  KE E  R+   +  +Q++ S + + 
Sbjct: 1245 EQEESIKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQE 1304

Query: 1493 SEKI 1496
             E++
Sbjct: 1305 KEQL 1308



 Score = 38.5 bits (88), Expect = 0.052
 Identities = 58/251 (23%), Positives = 106/251 (42%), Gaps = 51/251 (20%)

Query: 860  KEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHE 919
            +E    E+L +K +   +++ L  E+++   K   L+G+L  ++   +N D         
Sbjct: 1184 REVKNAEILRMKEQLR-EMENLRLESQQLIEKNWLLQGQLDDIKRQKENSD--------- 1233

Query: 920  KEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAE 979
                   QN  D + L+ E     Q   IKE     +IV E LK      + +  L   E
Sbjct: 1234 -------QNHPDNQQLKNE-----QEESIKERLAKSKIVEEMLKMKADLEEVQSALYNKE 1281

Query: 980  LQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEK 1039
            ++ L  +   E   TL+ +  QE E++    R  LEE+ +E ++   ++     E+++++
Sbjct: 1282 MECLRMTDEVERTQTLESKAFQEKEQL----RSKLEEMYEERERTSQEM-----EMLRKQ 1332

Query: 1040 EKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETEN 1099
             + L E   K+    +   K++  + LK                  KE ++  L +ETE 
Sbjct: 1333 VECLAEENGKLVGHQNLHQKIQYVVRLK------------------KENVR--LAEETEK 1372

Query: 1100 LRTEISKLNQK 1110
            LR E   L +K
Sbjct: 1373 LRAENVFLKEK 1383



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 39/176 (22%), Positives = 82/176 (46%), Gaps = 30/176 (17%)

Query: 870  LKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNE 929
            LKNE E  +   + +++  E  +K +K +L  ++  L NK+ E   +  E E    L+++
Sbjct: 1242 LKNEQEESIKERLAKSKIVEEMLK-MKADLEEVQSALYNKEMECLRMTDEVERTQTLESK 1300

Query: 930  KDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLK 989
              Q+  ++ +       +++E+ + RE              +++++LR +++ L + + K
Sbjct: 1301 AFQEKEQLRS-------KLEEMYEERE-----------RTSQEMEMLRKQVECLAEENGK 1342

Query: 990  ELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQE 1045
                   V H    +K+    R     LKKEN ++  + ++  AE +  KEK+  E
Sbjct: 1343 ------LVGHQNLHQKIQYVVR-----LKKENVRLAEETEKLRAENVFLKEKKRSE 1387



 Score = 35.8 bits (81), Expect = 0.34
 Identities = 43/202 (21%), Positives = 91/202 (45%), Gaps = 22/202 (10%)

Query: 1295 LQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKL 1354
            + E+    + QL+ + KR  E++       +A  QT   + LTR+K +K N +    + +
Sbjct: 369  VNEDTQGNVSQLQAEVKRLKEQLAE-----LASGQTPPESFLTRDK-KKTNYMEYFQEAM 422

Query: 1355 KSTMQQQERDKDLIESLSEDRARLLEEKKKLEEE--VSKLRSSSFVPSPYVATAPELYGA 1412
                + ++  K LIE +++     L+++K ++    + K R    +    +    E  G 
Sbjct: 423  LFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHK--ESRGG 480

Query: 1413 CAPELPGESDRSAVETADE-----GRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQ 1467
              PE   E DR   E  +E      +++     +  +++   H L EE +R+ LLE   +
Sbjct: 481  FLPE---EQDRLLSELRNEIQTLREQIEHHPRVAKYAMEN--HSLREENRRLRLLEPVKR 535

Query: 1468 LKEEENKRLNQRLMSQSMSSVS 1489
             +E + + + +  + ++ S +S
Sbjct: 536  AQEMDAQTIAK--LEKAFSEIS 555


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score =  105 bits (263), Expect = 3e-22
 Identities = 155/683 (22%), Positives = 299/683 (43%), Gaps = 68/683 (9%)

Query: 862  KHQKELLSLKNEYEGK--LDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHE 919
            K Q+EL    NE   K  L   +KE   + +   K K  LV  E++   K       +  
Sbjct: 541  KGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLV-FEKIQTLKSRAAGSAQGN 599

Query: 920  KEA------VICLQNEKDQKLLEMENIMHSQNCEIKE---LKQSREIV---LEDLKKLHV 967
             +A      V  L  +K +  +E+  +      E+K    +K+ RE +   LE+L+  H 
Sbjct: 600  NQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHN 659

Query: 968  ENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQ 1027
            E  E+   L+  L+  E    K LE+  QV+  +E       H+  + +L+ +  ++ ++
Sbjct: 660  EKVEENSTLQQRLEESEGELRKNLEELFQVKMERE------QHQTEIRDLQDQLSEMHDE 713

Query: 1028 IQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVE---LALKEAETDEIKILLEESRAQ 1084
            +  +     +EK   ++EL     DL D     E +   L  +E E   +K  L+E  + 
Sbjct: 714  LDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSS 773

Query: 1085 QKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISEL-ISR 1143
              + +  L EQ       E+  L + +++  +N +V  +      T E+DQ  +E+ +  
Sbjct: 774  HDQEMDKLKEQ----YDAELQALRESVEEATKNVEVLASRSN---TSEQDQAGTEMRVKL 826

Query: 1144 HEEESNILKA---ELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQ 1200
             +EE+  L+    EL +  +   +  E  K  + +  E   K + E+  LE        +
Sbjct: 827  LQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKE 886

Query: 1201 QEEKYEA--IIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEK 1258
            ++E   A   ++N  +  Q  +S   Q+++QL +KL  E ++  Q  L+  K E E    
Sbjct: 887  EKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQ--LRRLKNEMENERW 944

Query: 1259 ELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQ 1318
             L + ++ L+ ++A    ++++R  +S+L  ELQ +L E K K   +L E +++  E+  
Sbjct: 945  HLGKTIEKLQKEMA--DIVEASR--TSTL--ELQNQLDEYKEKNRRELAEMQRQLKEKTL 998

Query: 1319 NVRTSLIAEQQTNFNTVLTREKMRKENIINDLS----DKLKSTMQQQERDKDLIESLSED 1374
                S +   +      L  E++R      D +      L+ T++  E + +    L +D
Sbjct: 999  EAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDD 1058

Query: 1375 RARLLEEKK----KLEEEVSKLRSSSFVPSPYVATAPELYGACAPEL--------PGESD 1422
            R+RL+++ +    +LE E+ + R++S + S  ++ + E       EL          E D
Sbjct: 1059 RSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECD 1118

Query: 1423 RSAVETADEGRVDSA--METSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRL---N 1477
            + ++E  ++        +E S  S +E   ++ + + RI  LE  L+ +E +   L   N
Sbjct: 1119 KISLERQNKDLKSRIIHLEGSYRSSKEG--LVVQMEARIAELEDRLESEERDRANLQLSN 1176

Query: 1478 QRLMSQSMSSVSSRHSEKIAIRD 1500
            +RL  +    V     E +++ D
Sbjct: 1177 RRLERKVKELVMQVDDEHLSLTD 1199



 Score =  103 bits (256), Expect = 2e-21
 Identities = 142/596 (23%), Positives = 270/596 (45%), Gaps = 87/596 (14%)

Query: 845  RNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGL--IKETEENENKIKKLKGELVCL 902
            +N+ E  +  +E   +E+HQ E+  L+++     D L   K +E+ E      KG L+  
Sbjct: 681  KNLEELFQVKME---REQHQTEIRDLQDQLSEMHDELDSAKRSEDRE------KGALI-- 729

Query: 903  EEVLQNK-DNEFALVKHEKEAVICLQNEKDQKLLE--MENIMHSQNCEIKELKQSREIVL 959
            EE+LQ K D +  L+  E++  +  + E++   L+  ++  + S + E+ +LK+  +  L
Sbjct: 730  EELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAEL 789

Query: 960  EDLKKLHVENDEKLQLLRAELQSLEQSH---------LKELEDTLQVRHIQEFEKVMTDH 1010
            + L++   E  + +++L +   + EQ           L+E  + LQ R  +E E+ +   
Sbjct: 790  QALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRS-EELERRVAQL 848

Query: 1011 RVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAE 1070
            +  +E+LK +  +    +++   EI Q +E  +   K +   +S  R  LE EL   +  
Sbjct: 849  QRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRA-LENELEAAQGN 907

Query: 1071 ----TDEIKILLEESR--AQQKETLKSL---LEQETENLRTEISKLNQKIQDNNENYQVG 1121
                T E K L E+ +  ++QKE L+ L   +E E  +L   I KL +++ D  E  +  
Sbjct: 908  LSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTS 967

Query: 1122 LAELRTLMTIEKDQCISELISRHEE-ESNILKAELNKVTSLHNQ--------------AF 1166
              EL+  +   K++   EL     + +   L+AE +++T++  Q                
Sbjct: 968  TLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRA 1027

Query: 1167 EIEKNLKEQIIELQSK-LDSELSALERQKDEK---ITQQEEKYEAIIQNLEKDRQ----- 1217
            + E   K Q++E   K L+ EL A    KD++   + Q E+K   +   LE++R      
Sbjct: 1028 QDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLL 1087

Query: 1218 -KLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPA 1276
             + +S   +  EQL  +L  E+         +  LER+   K+L  ++ HLE        
Sbjct: 1088 SERISRSREQMEQLRNELLQERAARQDLECDKISLERQ--NKDLKSRIIHLEG------- 1138

Query: 1277 IDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEK-RKNEEMQNVRTSLIAEQQTNFNTV 1335
              S R     LV +++ ++ E +    ++LE +E+ R N ++ N R     ++       
Sbjct: 1139 --SYRSSKEGLVVQMEARIAELE----DRLESEERDRANLQLSNRRLERKVKE------- 1185

Query: 1336 LTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSK 1391
            L  +   +   + D  D+L   ++  +R    +E   E+  RL   KKKL+ E+ +
Sbjct: 1186 LVMQVDDEHLSLTDQKDQLSLRLKAMKRQ---VEEAEEEIDRLESSKKKLQRELEE 1238



 Score = 91.7 bits (226), Expect = 5e-18
 Identities = 111/475 (23%), Positives = 236/475 (49%), Gaps = 55/475 (11%)

Query: 866  ELLSLKNE-YEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVI 924
            +LL  +NE  +G+ + L +   + + +I+ LKG+    +E L+  + E   ++  +EA++
Sbjct: 825  KLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE---IRQLEEALV 881

Query: 925  CLQNEKDQKLLE---MENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQ 981
              + E+ + +     +EN + +    + +  Q ++ + E LK+   E  E+L+ L+ E++
Sbjct: 882  HARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKE-ESEQKEQLRRLKNEME 940

Query: 982  SLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEK 1041
            + E+ HL +  + LQ    +E   ++   R S  EL+ +    +++ +E +   + E ++
Sbjct: 941  N-ERWHLGKTIEKLQ----KEMADIVEASRTSTLELQNQ----LDEYKEKNRRELAEMQR 991

Query: 1042 QLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEES---RAQQKETLKSLLEQETE 1098
            QL+E  L+      T  K++ E+ L E E  + +   +E+   R   ++TLK  LE E E
Sbjct: 992  QLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKD-LEYELE 1050

Query: 1099 ---NLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAEL 1155
               +L+ + S+L ++++D     ++ L E R          +SE ISR  E+   L+ EL
Sbjct: 1051 AKSHLKDDRSRLVKQMEDKVSQLEMELEEER-----NNSDLLSERISRSREQMEQLRNEL 1105

Query: 1156 NKVTS----LHNQAFEIE---KNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAI 1208
             +  +    L      +E   K+LK +II L+    S    L  Q + +I + E++    
Sbjct: 1106 LQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDR---- 1161

Query: 1209 IQNLEKDRQKLVSSQ---EQDREQLIQKLNCE----KDEAIQTALKEFKLEREVVEKE-- 1259
            +++ E+DR  L  S    E+  ++L+ +++ E     D+  Q +L+   ++R+V E E  
Sbjct: 1162 LESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEE 1221

Query: 1260 ---LLEKVKHLENQIAKSPAI-DSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQE 1310
               L    K L+ ++ +   + +  +G  +S+  +L  +L++  +K L+ +++ +
Sbjct: 1222 IDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDL--RLKKLPSKVLDDMDDDD 1274


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
            [Homo sapiens]
          Length = 1354

 Score =  104 bits (260), Expect = 6e-22
 Identities = 146/670 (21%), Positives = 298/670 (44%), Gaps = 69/670 (10%)

Query: 834  SNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIK 893
            SN+ K     ++  I K++  L   ++ K + E     +    KLD ++KE +E  N+ +
Sbjct: 418  SNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNI--KLDKIMKELDEEGNQRR 475

Query: 894  KLKGELVCLEE---VLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKE 950
             L+  +  +E+   +LQ++ NE+   K E+E      NEK + +    + +  Q  ++K+
Sbjct: 476  NLESTVSQIEKEKMLLQHRINEYQR-KAEQE------NEKRRNVENEVSTLKDQLEDLKK 528

Query: 951  LKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDH 1010
            + Q+ ++  E L +L  + +E   LLR E  +  +      E +  +  ++   + + + 
Sbjct: 529  VSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQER 588

Query: 1011 RVSLEELKKENQQIINQIQ---ESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALK 1067
               LE  K +  +   Q+Q   E+         + + +L+ +++ L +    L+  L   
Sbjct: 589  NRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKV 648

Query: 1068 EAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRT 1127
            E E  E + +L  S  ++K  L+        +L  ++  L Q+++     ++V  A L  
Sbjct: 649  EGERKEAQDMLNHSE-KEKNNLEI-------DLNYKLKSLQQRLEQEVNEHKVTKARL-- 698

Query: 1128 LMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSEL 1187
                +K Q I       EE  ++   E+ K      +A E  +N   QI +  S LD +L
Sbjct: 699  ---TDKHQSI-------EEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDL 748

Query: 1188 SALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQ-KLNCEKDEAIQTAL 1246
                +QK E +T  +E+ E  ++NL      L   QE ++  L+Q +L  +  EA     
Sbjct: 749  KQ-SQQKLEHLTGNKERMEDEVKNL-----TLQLEQESNKRLLLQNELKTQAFEADNLKG 802

Query: 1247 KEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEK------- 1299
             E ++++E+    LLE  + LE ++A+       RG+   +  ELQ++L+ E+       
Sbjct: 803  LEKQMKQEI--NTLLEAKRLLEFELAQ--LTKQYRGNEGQM-RELQDQLEAEQYFSTLYK 857

Query: 1300 ---AKFLEQLEEQEK---RKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDK 1353
                +  E++EE+ +   +K +E+QN + +L A Q     T    E++ +  +     + 
Sbjct: 858  TQVKELKEEIEEKNRENLKKIQELQNEKETL-ATQLDLAETKAESEQLARGLLEEQYFEL 916

Query: 1354 LKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGAC 1413
             + + +   R++  I       +RL E    L +++  LR  +   +  +  A E Y   
Sbjct: 917  TQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEY--- 973

Query: 1414 APELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRI---MLLERTLQLKE 1470
              +L  E + S ++ A E  +++       +V +   +++ +  +I       + L+ KE
Sbjct: 974  --KLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKE 1031

Query: 1471 EENKRLNQRL 1480
            +EN++L   L
Sbjct: 1032 KENRKLQLEL 1041



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 105/431 (24%), Positives = 181/431 (41%), Gaps = 84/431 (19%)

Query: 1098 ENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNK 1157
            E+L+  I KL +++ +  +       + RT   I+ D+ + EL    +EE N  +     
Sbjct: 426  ESLQKTIYKLEEQLHNEMQLKDEMEQKCRT-SNIKLDKIMKEL----DEEGNQRR----- 475

Query: 1158 VTSLHNQAFEIEKN---LKEQIIELQSKLDSELSALERQKDEKIT--QQEEKYEAIIQNL 1212
              +L +   +IEK    L+ +I E Q K + E       ++E  T   Q E  + + QN 
Sbjct: 476  --NLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNS 533

Query: 1213 EKDRQKLVSSQEQDREQLIQKLNCEKDEAIQ-----TALKEFKLEREVVEKELLEKVKHL 1267
            +   +KL   Q+Q  E+    L  E D A++     T + +   + E + +EL E+ + L
Sbjct: 534  QLANEKLSQLQKQ-LEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRIL 592

Query: 1268 ENQIAKSP-----------AIDSTRGDSSSLVAELQEK---LQEEKAKFLEQLEEQEKRK 1313
            EN  +++            A    RG  S ++ +LQ +   LQEE       LE+ E  +
Sbjct: 593  ENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGER 652

Query: 1314 NEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSE 1373
             E                   +L   +  K N+  DL+ KLKS  Q+ E++   +     
Sbjct: 653  KEAQD----------------MLNHSEKEKNNLEIDLNYKLKSLQQRLEQE---VNEHKV 693

Query: 1374 DRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGR 1433
             +ARL ++ + +EE  S                      C  E   + +R A E A+   
Sbjct: 694  TKARLTDKHQSIEEAKS-------------------VAMCEMEKKLKEEREAREKAENRV 734

Query: 1434 VDSAMETSMMSV-----QENIHMLSEEKQRIM--LLERTLQLKEEENKR--LNQRLMSQS 1484
            V    + SM+ V     Q+ +  L+  K+R+   +   TLQL++E NKR  L   L +Q+
Sbjct: 735  VQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQA 794

Query: 1485 MSSVSSRHSEK 1495
              + + +  EK
Sbjct: 795  FEADNLKGLEK 805



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 52/242 (21%), Positives = 122/242 (50%), Gaps = 29/242 (11%)

Query: 863  HQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNK--------DNEFA 914
            ++ ++  LK E E K    +K+ +E +N+ + L  +L   E   +++        +  F 
Sbjct: 856  YKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFE 915

Query: 915  LVKHEKEAVICLQNE---KDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDE 971
            L +  K+A    + E   KD  +  +E        +I+ L++  E + E +KK   E + 
Sbjct: 916  LTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKK--AEEEY 973

Query: 972  KLQLLRAELQSLEQSHLKEL--EDTLQVRHIQEFEKVMT--DHRVS--------LEELKK 1019
            KL+    E+ +L+ +  K +  E TL+ + + +  ++M   D ++         L + +K
Sbjct: 974  KLEK-EEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEK 1032

Query: 1020 ENQQI---INQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKI 1076
            EN+++   +NQ +E   +++ + +K+L +++ ++ +    R +L+++LA KE++ ++++ 
Sbjct: 1033 ENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQLRA 1092

Query: 1077 LL 1078
             L
Sbjct: 1093 KL 1094



 Score = 39.3 bits (90), Expect = 0.031
 Identities = 38/132 (28%), Positives = 61/132 (46%), Gaps = 14/132 (10%)

Query: 1266 HLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLI 1325
            +  N+   S A  +    SS+    LQE LQ+   K  EQL  + + K+E  Q  RTS I
Sbjct: 399  YYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNI 458

Query: 1326 AEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEE---- 1381
              +       L  E  ++ N        L+ST+ Q E++K L++    +  R  E+    
Sbjct: 459  --KLDKIMKELDEEGNQRRN--------LESTVSQIEKEKMLLQHRINEYQRKAEQENEK 508

Query: 1382 KKKLEEEVSKLR 1393
            ++ +E EVS L+
Sbjct: 509  RRNVENEVSTLK 520


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  103 bits (258), Expect = 1e-21
 Identities = 189/841 (22%), Positives = 362/841 (43%), Gaps = 126/841 (14%)

Query: 764  LYSSVINAIDSRRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFR 823
            LY  +   + S   +      KE+F   T L   LE+     ++    + ++ ++    +
Sbjct: 832  LYFKIKPLLKSAEREKEMASMKEEF---TRLKEALEKSEARRKELEEKMVSLLQEKNDLQ 888

Query: 824  TFVQKEQCDFSNSLKCTAVEIRNIIE---KVK-----------CSLEITLKE-KHQKELL 868
              VQ EQ + +++ +     I+N I+   KVK            + E+T K+ K + E  
Sbjct: 889  LQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECS 948

Query: 869  SLK---NEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEF-ALVKHEKEAVI 924
             LK   ++ E  L  + KE    ENK+K L  E+  L+E++     E  AL +  ++A+ 
Sbjct: 949  ELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD 1008

Query: 925  CLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLE 984
             LQ E+D+      N +     ++++     E  LE  KK+ ++ +   + L  +L+  +
Sbjct: 1009 DLQAEEDKV-----NTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1063

Query: 985  QSHL------KELEDTLQVR--HIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEII 1036
            +S +      ++L++ L+ +   +      + D +    +L+K+ +++  +I+E   E+ 
Sbjct: 1064 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELE 1123

Query: 1037 QEKEKQLQELKLKVSDLSDTRCKLEVELALKEAE-TDEIKILLEESRAQQKETLKSLLEQ 1095
             E+  + +  KL+ SDLS  R   E+   L+EA     ++I + + R  + + ++  LE+
Sbjct: 1124 AERTARAKVEKLR-SDLS--RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE 1180

Query: 1096 ETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAEL 1155
             T       + L +K  D+       +AEL      E+   +  +  + E+E +  K EL
Sbjct: 1181 ATLQHEATAAALRKKHADS-------VAELG-----EQIDNLQRVKQKLEKEKSEFKLEL 1228

Query: 1156 NKVTSLHNQAFEIEKN-------LKEQIIELQSK----------LDSELSALERQKDEKI 1198
            + VTS   Q  + + N       L++Q+ E +SK          L S+ + L+ +  E  
Sbjct: 1229 DDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELS 1288

Query: 1199 TQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEK--DEAIQTALKEFKLEREVV 1256
             Q +EK EA+I  L + +       E  + QL +++  +     A+Q+A  +  L RE  
Sbjct: 1289 RQLDEK-EALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQY 1347

Query: 1257 EKELLEKVKHLENQIAKSPA-IDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQE----- 1310
            E+E   K + L+  ++K+ + +   R    +   +  E+L+E K K  ++L+E E     
Sbjct: 1348 EEETEAKAE-LQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEA 1406

Query: 1311 -------------KRKNE--------EMQNVRTSLIAEQQTNFNTVLTREKMRKENIIND 1349
                         + +NE        E  N   + + ++Q NF+ +L   K + E   ++
Sbjct: 1407 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1466

Query: 1350 LSDKLK---STMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATA 1406
            L    K   S   +  + K+  E   E       E K L+EE+S L            T 
Sbjct: 1467 LESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL---GSSGKTI 1523

Query: 1407 PELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQEN----IHMLSEEKQRIMLL 1462
             EL          E  R  +E A++  + SA+E +  S++      +    E  Q    +
Sbjct: 1524 HEL----------EKVRKQLE-AEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEI 1572

Query: 1463 ERTLQLKEEE---NKRLNQRLMSQSMSSVSSR---HSEKIAIRDFQVGDLVLIILDERHD 1516
            ER L  K+EE    KR + R++    +S+ +     +E + ++    GDL  + +   H 
Sbjct: 1573 ERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHA 1632

Query: 1517 N 1517
            N
Sbjct: 1633 N 1633



 Score = 88.6 bits (218), Expect = 4e-17
 Identities = 121/581 (20%), Positives = 260/581 (44%), Gaps = 83/581 (14%)

Query: 850  KVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNK 909
            + K  L+  L  K   E+   + +YE      I+ TEE E   KKL   L   EE ++  
Sbjct: 1352 EAKAELQRVLS-KANSEVAQWRTKYE---TDAIQRTEELEEAKKKLAQRLQEAEEAVEAV 1407

Query: 910  DNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVEN 969
            + + + ++  K     LQNE +  ++++E   ++    + + +++ + +L + K+ + E+
Sbjct: 1408 NAKCSSLEKTKHR---LQNEIEDLMVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEES 1463

Query: 970  DEKLQLLRAELQSLEQSHLK---ELEDTLQVRHIQEFEKVMTDHRVSLEELKK------- 1019
              +L+  + E +SL     K     E++L+  H++ F++   + +  + +L +       
Sbjct: 1464 QSELESSQKEARSLSTELFKLKNAYEESLE--HLETFKRENKNLQEEISDLTEQLGSSGK 1521

Query: 1020 ---ENQQIINQIQESHAEI---IQEKEKQLQ--ELKLKVSDLSDTRCKLEVELALKEAET 1071
               E +++  Q++    E+   ++E E  L+  E K+  + L   + K E+E  L  AE 
Sbjct: 1522 TIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL--AEK 1579

Query: 1072 DEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLA-------- 1123
            DE     + +  +  ++L++ L+ ET + R E  ++ +K++ +    ++ L+        
Sbjct: 1580 DEEMEQAKRNHLRVVDSLQTSLDAETRS-RNEALRVKKKMEGDLNEMEIQLSHANRMAAE 1638

Query: 1124 ---ELRTLMTIEKDQCIS------------ELISRHEEESNILKAELNKVTSLHNQAFEI 1168
               ++++L ++ KD  I             E I+  E  +N+L+AEL ++ ++  Q    
Sbjct: 1639 AQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS 1698

Query: 1169 EKNLKEQIIEL-----------------QSKLDSELSALERQKDEKITQ---QEEKYEAI 1208
             K  ++++IE                  + K+D++LS L+ + +E + +    EEK +  
Sbjct: 1699 RKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKA 1758

Query: 1209 IQNL---------EKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKE 1259
            I +          E+D    +   +++ EQ I+ L    DEA Q ALK  K + + +E  
Sbjct: 1759 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEAR 1818

Query: 1260 LLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQN 1319
            + E    LE +  ++         S   + EL  + +E++   L   +  +K + +    
Sbjct: 1819 VRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAY 1878

Query: 1320 VRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQ 1360
             R +  AE+Q N N    R+   + +   + +D  +S + +
Sbjct: 1879 KRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNK 1919



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 148/721 (20%), Positives = 300/721 (41%), Gaps = 101/721 (14%)

Query: 793  SLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIE-KV 851
            +L  Q+   R  A+++  S+     DL   R  +Q E  + S  L      I  +   K+
Sbjct: 1251 TLEDQMNEHRSKAEETQRSVN----DLTSQRAKLQTENGELSRQLDEKEALISQLTRGKL 1306

Query: 852  KCSLEITLKEKHQKELLSLKNEYEGKLDG------LIKETEENENKIKKLKGELVCLEEV 905
              + ++   ++  +E +  KN     L        L++E  E E + K        L+ V
Sbjct: 1307 TYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAE------LQRV 1360

Query: 906  LQNKDNEFAL--VKHEKEAVICLQNEKD------QKLLEMENIMHSQNCEIKELKQSREI 957
            L   ++E A    K+E +A+   +  ++      Q+L E E  + + N +   L++++  
Sbjct: 1361 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHR 1420

Query: 958  VLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEEL 1017
            +  +++ L V+  E+     A L   +++  K L +  Q    +E +  +   +     L
Sbjct: 1421 LQNEIEDLMVDV-ERSNAAAAALDKKQRNFDKILAEWKQ--KYEESQSELESSQKEARSL 1477

Query: 1018 KKENQQIINQIQES--HAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIK 1075
              E  ++ N  +ES  H E  + + K LQE   ++SDL++       +L        E++
Sbjct: 1478 STELFKLKNAYEESLEHLETFKRENKNLQE---EISDLTE-------QLGSSGKTIHELE 1527

Query: 1076 ILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQ 1135
             + ++  A++ E L+S LE+   +L  E  K+ +   + N+      AE+   +  EKD+
Sbjct: 1528 KVRKQLEAEKME-LQSALEEAEASLEHEEGKILRAQLEFNQIK----AEIERKLA-EKDE 1581

Query: 1136 CISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLD-SELSALERQK 1194
             + +    H    + L+  L+  T   N+A  ++K ++  + E++ +L  +   A E QK
Sbjct: 1582 EMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQK 1641

Query: 1195 DEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNC--EKDEAIQTALKEFKLE 1252
              K           +Q+L KD Q  +    +  + L + +     ++  +Q  L+E    
Sbjct: 1642 QVKS----------LQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEEL--- 1688

Query: 1253 REVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKR 1312
            R VVE+    +    +  I  S  +      ++SL+         +K K    L + +  
Sbjct: 1689 RAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI--------NQKKKMDADLSQLQTE 1740

Query: 1313 KNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLS 1372
              E +Q  R +    ++   +  +  E+++KE   +   +++K  M+Q    KDL   L 
Sbjct: 1741 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ--TIKDLQHRLD 1798

Query: 1373 E-DRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADE 1431
            E ++  L   KK+L++  +++R                      EL  E  R+A      
Sbjct: 1799 EAEQIALKGGKKQLQKLEARVRE------------------LENELEAEQKRNAESV--- 1837

Query: 1432 GRVDSAMETSMMSVQENIHMLSEEKQRIMLLE---RTLQLKEEENKRLNQRLMSQSMSSV 1488
                  M  S   ++E  +   E+++ ++ L+     LQLK +  KR  +    Q+ +++
Sbjct: 1838 ----KGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNL 1893

Query: 1489 S 1489
            S
Sbjct: 1894 S 1894


>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform a
            [Homo sapiens]
          Length = 1007

 Score =  103 bits (257), Expect = 1e-21
 Identities = 147/669 (21%), Positives = 282/669 (42%), Gaps = 116/669 (17%)

Query: 796  VQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNI---IEKVK 852
            + +E  + + +D    ++ + E   +    + K + D     + T+  I      I  ++
Sbjct: 320  LHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQ 379

Query: 853  CSL-EITLKEKHQKELLSLKNEYEGKLDGLIKETEEN----ENKIKKLKGELV---CLEE 904
            C L E+ L+    ++L   K+++  + D +++E E+     +N + K + EL    C+  
Sbjct: 380  CRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMAT 439

Query: 905  VLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIV------ 958
             L+    E    K ++     LQ E  +    +E     +    ++  Q +E        
Sbjct: 440  ELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCH 499

Query: 959  LEDLKK-------LHVENDEKLQLLRAELQSLE-QSHLKELEDTLQVRHIQEFEKVMTDH 1010
            LED ++       L  +  + +Q L+ ELQ L+ +S + E E T   + ++E    +++ 
Sbjct: 500  LEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEA 559

Query: 1011 RVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAE 1070
               LE   KE +Q+    Q++ AE   +    L  +K +  +    +CKLE +L      
Sbjct: 560  LRKLENSDKEKRQL----QKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDL------ 609

Query: 1071 TDEIKILLEESRAQQKETLK--SLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTL 1128
              E   LLE+ R Q K++ +   L+E E E LR E  K ++ +++N+   +     LR  
Sbjct: 610  -QEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAE 668

Query: 1129 MTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNL---KEQIIELQSKLDS 1185
            +     QC S            L++ LNK  +      ++ K +   KE ++ LQ++LD 
Sbjct: 669  L-----QCCSTQ----------LESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDK 713

Query: 1186 ELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEA---- 1241
             L   +      IT+  E Y+A+         +  ++ + D  Q ++KLN    E     
Sbjct: 714  ALQKEKHYLQTTITK--EAYDAL--------SRKSAACQDDLTQALEKLNHVTSETKSLQ 763

Query: 1242 ---IQTALKEFKLEREVVEKELLEKVKHLENQIAKSP-----------AIDSTRGDSSSL 1287
                QT  K+ +LE E++  E  E++K L  ++ K             A D    + S  
Sbjct: 764  QSLTQTQEKKAQLEEEIIAYE--ERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQ 821

Query: 1288 VAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQ------------------ 1329
            V + Q++ Q +  K L   EEQ +   EEM  ++ +L+ + +                  
Sbjct: 822  VLQWQKQHQND-LKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLY 880

Query: 1330 -------TNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEK 1382
                   TN      ++K+  E + N L +++K  + +   +KD + S+      L +E 
Sbjct: 881  RGNDQIMTNLEQWAKQQKVANEKLGNQLREQVK-YIAKLSGEKDHLHSV---MVHLQQEN 936

Query: 1383 KKLEEEVSK 1391
            KKL++E+ +
Sbjct: 937  KKLKKEIEE 945



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 122/580 (21%), Positives = 255/580 (43%), Gaps = 77/580 (13%)

Query: 873  EYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQ 932
            E + +L  + ++  + ++ I++L+ +L C   ++  ++   AL+K + +   C    +  
Sbjct: 237  ETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREK--ALIKLQADFASCTATHRYP 294

Query: 933  KLLEMENIMHSQNCEI--KELKQSREIVLEDLKKLHVENDEKL-QLLRAELQSLEQSHLK 989
                      S+ CE   K LK  +E   +D + LHVE  + L + LR EL+++ +    
Sbjct: 295  P-------SSSEECEDIKKILKHLQE--QKDSQCLHVEEYQNLVKDLRVELEAVSEQKRN 345

Query: 990  ELEDTLQVR------------HIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQ 1037
             ++D +++             HI+  +K +T  +  L+EL+ E  +   ++     + +Q
Sbjct: 346  IMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTET-QKLTLKKDKFLQ 404

Query: 1038 EKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRA-QQKETLKSLLEQE 1096
            EK++ LQEL+ K++ + ++  K E EL  ++    E+++ ++E++  + KE     L+ E
Sbjct: 405  EKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAE 464

Query: 1097 TENLRTEISKLNQK---------------------IQDNNENYQVGL----------AEL 1125
             + L+  + +  Q+                     ++D     Q GL           EL
Sbjct: 465  VQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQEL 524

Query: 1126 -RTLMTIEKDQCISEL-----ISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIEL 1179
             R L  ++K+  ++E        R EE S  L   L K+ +   +  +++K + EQ +++
Sbjct: 525  QRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKM 584

Query: 1180 QSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDR------EQLIQK 1233
               LD  +    R++     + EE  +   + LE  R++L  S+E ++      E L Q+
Sbjct: 585  NDMLD-RIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQE 643

Query: 1234 LNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQE 1293
               +KD+ ++   ++ + E E +  EL      LE+ + K         D +  +A  +E
Sbjct: 644  FK-KKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKE 702

Query: 1294 KLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDK 1353
             L   +A    QL++  +++   +Q   T    +  +  +     +  +    +N ++ +
Sbjct: 703  SLMSLQA----QLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSE 758

Query: 1354 LKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLR 1393
             KS  Q   + ++    L E+     E  KKL  E+ KLR
Sbjct: 759  TKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLR 798


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  103 bits (257), Expect = 1e-21
 Identities = 143/666 (21%), Positives = 296/666 (44%), Gaps = 98/666 (14%)

Query: 790  DHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIE 849
            D   +N +L   +   +D    ++   +DL      V+KE+    N +K    E+  + E
Sbjct: 929  DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDE 988

Query: 850  KV-KCSLEI-TLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVL- 906
             + K + E   L+E HQ+ L  L+ E E K++ L K   + E +++ L+  L   +++  
Sbjct: 989  TIAKLTREKKALQEAHQQALDDLQAE-EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRV 1047

Query: 907  ---QNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLK 963
               +NK      +K  +E+++ L+N+K Q    ++  +  ++ E  +L+      +ED +
Sbjct: 1048 DLERNKRKLEGDLKLAQESILDLENDKQQ----LDERLKKKDFEYCQLQSK----VEDEQ 1099

Query: 964  KLHVENDEKLQLLRAELQSLEQS--------------------HLKELEDTL-------- 995
             L ++  +K++ L+A ++ LE+                      L+EL + L        
Sbjct: 1100 TLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTS 1159

Query: 996  -QVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEII--------------QEKE 1040
             Q+   ++ E      R  LEE   +++ ++  +++ HA+ +              Q+ E
Sbjct: 1160 TQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLE 1219

Query: 1041 KQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETE-- 1098
            K+  E KL++ DLS +   +    A  E     ++  L E+R + +E  +SL E  T+  
Sbjct: 1220 KEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKS 1279

Query: 1099 NLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKV 1158
             L+TE  +L++++++  E+    L+  +   T    Q   EL  + EEE+    A  + +
Sbjct: 1280 RLQTEAGELSRQLEE-KESIVSQLSRSKQAFT----QQTEELKRQLEEENKAKNALAHAL 1334

Query: 1159 TS------LHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNL 1212
             S      L  + +E E+  K ++    SK +SE++    + +    Q+ E+       L
Sbjct: 1335 QSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEE-------L 1387

Query: 1213 EKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIA 1272
            E+ ++KL    +   EQ+         EA+       +  ++ ++ E+ + +  +E   +
Sbjct: 1388 EEAKKKLAQRLQDSEEQV---------EAVNAKCASLEKTKQRLQGEVEDLMVDVERANS 1438

Query: 1273 KSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNE--EMQNVRTSLIAEQQT 1330
             + A+D  + +   ++AE + K +E +A+    L+E      E  +++N     + + +T
Sbjct: 1439 LAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLET 1498

Query: 1331 NFNTVLTREKMRKENIINDLSDKLK---STMQQQERDKDLIESLSEDRARLLEE-KKKLE 1386
                 + RE    E  I DL++++     T+ + E+ +  IE    D    LEE +  LE
Sbjct: 1499 -----VKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALE 1553

Query: 1387 EEVSKL 1392
             E +K+
Sbjct: 1554 HEEAKI 1559



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 144/674 (21%), Positives = 284/674 (42%), Gaps = 106/674 (15%)

Query: 852  KCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDN 911
            K  L  TL+E     L  L    +    G +   E    K+ + +  + C++  +++   
Sbjct: 767  KAGLLGTLEEMRDDRLAKLITRTQAVCRGFLMRVEFQ--KMVQRRESIFCIQYNIRS--- 821

Query: 912  EFALVKHE-------KEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKK 964
             F  VKH        K   +    E ++++  M+        E+ + +  R+ + E L  
Sbjct: 822  -FMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVT 880

Query: 965  LHVE-NDEKLQ-------LLRAE------LQSLEQSHLKELEDTLQVRHIQEFEKVMTDH 1010
            L  E ND +LQ       LL AE      +++  Q   K  E T +    +E    +T  
Sbjct: 881  LVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAK 940

Query: 1011 RVSLEELKKENQQIINQIQESHAEIIQEK---EKQLQELKLKVSDLSDTRCKLEVE-LAL 1066
            +  LE+   E ++ I+ ++ + A++ +EK   E +++ L  ++S L +T  KL  E  AL
Sbjct: 941  KRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKAL 1000

Query: 1067 KEAETDEIKIL-LEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAEL 1125
            +EA    +  L  EE +       KS LEQ+ E+L + + +  +K++ + E         
Sbjct: 1001 QEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQ-EKKLRVDLE--------- 1050

Query: 1126 RTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIE---LQSK 1182
            R    +E D                LK     +  L N   ++++ LK++  E   LQSK
Sbjct: 1051 RNKRKLEGD----------------LKLAQESILDLENDKQQLDERLKKKDFEYCQLQSK 1094

Query: 1183 LDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQ--DREQLIQKLNCEKDE 1240
            ++ E   L  Q  +KI + + + E + + +E +R     +++Q  D  + +++L+   +E
Sbjct: 1095 VEDE-QTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEE 1153

Query: 1241 AIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKA 1300
            A      + +L ++  E E L+  + LE    +  A          +VA L++K  +  A
Sbjct: 1154 AGGVTSTQIELNKK-REAEFLKLRRDLEEATLQHEA----------MVAALRKKHADSVA 1202

Query: 1301 KFLEQLEEQEKRKNE-EMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQ 1359
            +  EQ++  ++ K + E +     L  +  ++    +++ K   E I   L D+L     
Sbjct: 1203 ELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARG 1262

Query: 1360 QQERDKDLIESLSEDRARLLEE----KKKLEEEVSKLRSSSFVPSPYVATAPELYGACAP 1415
            + E  +  +  L+  ++RL  E     ++LEE+ S +   S     +     EL      
Sbjct: 1263 KNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEEL------ 1316

Query: 1416 ELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKR 1475
                       +  +E +  +A+  ++ S + +  +L E+ +           +E+E K 
Sbjct: 1317 ---------KRQLEEENKAKNALAHALQSSRHDCDLLREQYE-----------EEQEGKA 1356

Query: 1476 LNQRLMSQSMSSVS 1489
              QR +S++ S V+
Sbjct: 1357 ELQRALSKANSEVA 1370



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 112/572 (19%), Positives = 239/572 (41%), Gaps = 89/572 (15%)

Query: 860  KEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHE 919
            + K++ + +    E E     L +  +++E +++ +  +   LE+  Q    E   +  +
Sbjct: 1373 RTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVD 1432

Query: 920  KEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAE 979
             E    L    D+K    + ++     + +E +   E  L++ + L   + E  +L  A 
Sbjct: 1433 VERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSL---STELFKLKNAY 1489

Query: 980  LQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEI-IQE 1038
             ++L+Q    + E+    + I +  + + ++  ++ EL+K  +QI  +++++  ++ ++E
Sbjct: 1490 EEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQI--ELEKADIQLALEE 1547

Query: 1039 KEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETE 1098
             E  L+  + K+  +     +++ E+  K AE DE    L+ +  +  ET++S L+ E  
Sbjct: 1548 AEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVR 1607

Query: 1099 NLRTEISKLNQKIQDNNENYQVGLAE-----------LRTLMTIEKD------------Q 1135
            + R E  +L +K++ +    ++ L+            LR++    KD            +
Sbjct: 1608 S-RNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQE 1666

Query: 1136 CISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQ------------------II 1177
             + E ++  E  +N+L+AE+ ++ +   Q  E  + L EQ                  +I
Sbjct: 1667 DLKEQLAIVERRANLLQAEVEELRATLEQT-ERARKLAEQELLDSNERVQLLHTQNTSLI 1725

Query: 1178 ELQSKLDSELSALERQKDEK---ITQQEEKYEAIIQNL---------EKDRQKLVSSQEQ 1225
              + KL+++L  L+ + ++        EEK +  I +          E+D    +   ++
Sbjct: 1726 HTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1785

Query: 1226 DREQLIQKLNCEKDEAIQTALK--------------EFKLEREVVEKELLEKVKHLENQI 1271
            + EQ ++ L    DEA Q ALK              E + E E  +K+  E VK L    
Sbjct: 1786 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYE 1845

Query: 1272 AKSPAIDSTRGDSSSLVAELQ---EKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSL---- 1324
             +   +     +    V  LQ   +KLQ +   +  Q EE +++ N  +   R +     
Sbjct: 1846 RRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELE 1905

Query: 1325 -------IAEQQTNFNTVLTREKMRKENIIND 1349
                   IAE Q N     TR+      ++++
Sbjct: 1906 EAEERADIAESQVNKLRAKTRDFTSSRMVVHE 1937



 Score = 38.5 bits (88), Expect = 0.052
 Identities = 72/363 (19%), Positives = 159/363 (43%), Gaps = 69/363 (19%)

Query: 1187 LSALERQKDEKITQQEEKYEAIIQN--LEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQT 1244
            L  LE  +D+++ +   + +A+ +   +  + QK+V    Q RE +           IQ 
Sbjct: 771  LGTLEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMV----QRRESIF---------CIQY 817

Query: 1245 ALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLE 1304
             ++ F   +     +L  K+K         P + S   +    +A ++E+ Q+ K    +
Sbjct: 818  NIRSFMNVKHWPWMKLFFKIK---------PLLKSAETEKE--MATMKEEFQKTK----D 862

Query: 1305 QLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIIN--DLSDKL-KSTMQQQ 1361
            +L + E  K +E++    +L+ E+    N +  + +   EN+++  +  D+L K+  Q +
Sbjct: 863  ELAKSEA-KRKELEEKLVTLVQEK----NDLQLQVQAESENLLDAEERCDQLIKAKFQLE 917

Query: 1362 ERDKDLIESLSEDR---ARLLEEKKKLEEEVSKLRSS--------SFVPSPYVATAPELY 1410
             + K++ E   ++    A L  +K+KLE+E S+L+          + V     AT  ++ 
Sbjct: 918  AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 977

Query: 1411 GACAPELPGESDRSAVETADEGRVDSAMETSMMSVQ---ENIHMLSEEKQRI-------- 1459
                 EL G  +  A  T ++  +  A + ++  +Q   + ++ L++ K ++        
Sbjct: 978  N-LTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLE 1036

Query: 1460 --MLLERTLQLKEEENKRLNQRLMSQSMSSV------SSRHSEKIAIRDFQVGDLVLIIL 1511
              +  E+ L++  E NKR  +  +  +  S+        +  E++  +DF+   L   + 
Sbjct: 1037 SSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVE 1096

Query: 1512 DER 1514
            DE+
Sbjct: 1097 DEQ 1099


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score =  102 bits (255), Expect = 2e-21
 Identities = 140/608 (23%), Positives = 274/608 (45%), Gaps = 63/608 (10%)

Query: 826  VQKEQCDFSNSLKCTAVEIRNI-IEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKE 884
            ++KE      S+K T+ ++  I  EK +   E+    +H KE      E E +L  L KE
Sbjct: 585  IEKENKILHESIKETSSKLSKIEFEKRQIKKEL----EHYKEKGERAEELENELHHLEKE 640

Query: 885  TEENENKIKKLKGELVCLE-EVLQNKDNEFALVKHE-KEAVICLQNEKDQ-KLLEMENI- 940
             E  + KI  LK  + C + E L+ +++E      + K+ +   +N   Q + LE EN  
Sbjct: 641  NELLQKKITNLK--ITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQ 698

Query: 941  MHSQNCEIKELKQSREIVLEDLKKLHVENDE---KLQLLRAELQSLEQSHLK--ELEDTL 995
            +  +N E++   +S +     + +L +EN E   + + L+  L+ L+ S  K   LE + 
Sbjct: 699  LDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSY 758

Query: 996  QVRHI--QEFEKVMTDHRVSLEELKKENQ--QIINQIQESHAEIIQEKEKQLQELKLKVS 1051
            Q   I  Q  +K + +    +++L+ E Q  ++ NQ  + + E ++   K+L++L+ +  
Sbjct: 759  QGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818

Query: 1052 DLSDTRCKLEVELALKEAETDEIKILLE--ESRAQQKETLKSLLEQETENLRTEIS---- 1105
             L     +LE +    E E   ++   E  ++  ++       LE+E + L  EI     
Sbjct: 819  SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878

Query: 1106 ---KLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKA--ELNKVTS 1160
               +L +  ++N E  +    +++TL+T+ +D  +SE +   +  +++ K   EL K+  
Sbjct: 879  SCVRLKELEKENKELVKRATIDIKTLVTLRED-LVSEKLKTQQMNNDLEKLTHELEKIGL 937

Query: 1161 LHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLV 1220
               +    E++  ++   L+SKL+S L      K+EKI   E + E      ++ RQ+L 
Sbjct: 938  NKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELK 997

Query: 1221 S--------SQEQDREQLIQKL-------NCEKDEAIQTALKEFKLEREVVEKELLEKVK 1265
            +         Q QD E+++Q         N  + E+ +T  +  K++  ++E E      
Sbjct: 998  TVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATL 1057

Query: 1266 HLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQ---LEEQEKRKNEEMQNVRT 1322
              E Q  K+  +      +++L A++   LQ +     EQ   L+ Q  +   E   + +
Sbjct: 1058 QAEKQALKTQ-LKQLETQNNNLQAQILA-LQRQTVSLQEQNTTLQTQNAKLQVENSTLNS 1115

Query: 1323 SLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSED--RARLLE 1380
               +    N   ++ +  +  EN         +S ++++E  K L +SL +D  +  LL 
Sbjct: 1116 QSTSLMNQNAQLLIQQSSLENEN---------ESVIKEREDLKSLYDSLIKDHEKLELLH 1166

Query: 1381 EKKKLEEE 1388
            E++  E E
Sbjct: 1167 ERQASEYE 1174



 Score = 98.6 bits (244), Expect = 4e-20
 Identities = 179/774 (23%), Positives = 322/774 (41%), Gaps = 136/774 (17%)

Query: 855  LEITLKEKHQKELLSLKNE-----YEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNK 909
            +EI LK   Q+ +  L +      Y  +LD L     E   ++ KL+ E+   +E L + 
Sbjct: 284  MEIELKRLQQENMNLLSDARSARMYRDELDAL----REKAVRVDKLESEVSRYKERLHDI 339

Query: 910  DNEFALVKHEKEAVICLQNEK-------------DQKLLEMENIMHSQNCEIKELKQSRE 956
            +   A V+  KE    L   K               KL E+E        ++ +++  R+
Sbjct: 340  EFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERD 399

Query: 957  IVLEDLKKLHVENDEKLQLLRAELQSLEQS-HLK-ELEDTLQVRHIQEFEKVMTDHRVS- 1013
            +   D KK+    +E + L  A+ QS+++S HL  ELE   +   + E  +    H V+ 
Sbjct: 400  M---DRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNE 456

Query: 1014 -----LEELKKENQQIINQIQE---------SHAEIIQEKEKQLQELKLKVSDLSDT--- 1056
                 L +L+ ENQ +   ++E          +A  I + EK+ Q L  KV  L +    
Sbjct: 457  LTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQ 516

Query: 1057 ------RCK-LEVELALKEAETDE-IKILLEESRAQQKETLKSLLEQETENLRTEISKLN 1108
                   C+ L  +L  ++A+ ++ I+ L E S  Q K     +LEQE E+L   +S L 
Sbjct: 517  EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIK-----ILEQENEHLNQTVSSLR 571

Query: 1109 QKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELN-------KVTSL 1161
            Q+ Q + E  +V   E    +  E  +  S  +S+ E E   +K EL        +   L
Sbjct: 572  QRSQISAEA-RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630

Query: 1162 HNQAFEIEKN---LKEQIIELQ------SKLDSELSALERQKDEKITQQEEKYEAI---I 1209
             N+   +EK    L+++I  L+        L+ E S LER+ + K+ +  + ++ +   +
Sbjct: 631  ENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE-NRKLKKTLDSFKNLTFQL 689

Query: 1210 QNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTAL--KEFKLEREVVEK--ELLEKV- 1264
            ++LEK+  +L   +  +  + ++ L C   +  Q  L  KE + E+E ++K  ELL+   
Sbjct: 690  ESLEKENSQL-DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASF 748

Query: 1265 ---------------------KHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEK--AK 1301
                                 K LEN   K   ++S   D       LQ+ L+E K  +K
Sbjct: 749  KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSK 808

Query: 1302 FLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQ 1361
             LEQLE++ K   +E   +      +Q    N  L ++   K+  + + + K+ +  ++ 
Sbjct: 809  RLEQLEKENKSLEQETSQLEKD--KKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKEN 866

Query: 1362 ERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGES 1421
            +     I    E   RL    K+LE+E  +L   + +    + T  E       +L  E 
Sbjct: 867  KTLSKEIGIYKESCVRL----KELEKENKELVKRATIDIKTLVTLRE-------DLVSEK 915

Query: 1422 DRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLE--------RTLQLKEEEN 1473
             ++     D  ++   +E   ++ +  +H       R  LLE        ++L++KEE+ 
Sbjct: 916  LKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKI 975

Query: 1474 KRLNQRLMSQSMSSVSSRHSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTL 1527
              L  RL   +  +   R   K   ++++        L +R D   +   SP +
Sbjct: 976  AALEARLEESTNYNQQLRQELKTVKKNYEA-------LKQRQDEERMVQSSPPI 1022



 Score = 94.7 bits (234), Expect = 6e-19
 Identities = 149/688 (21%), Positives = 296/688 (43%), Gaps = 87/688 (12%)

Query: 830  QCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENE 889
            Q D    LK  A+ ++ +I++         +++H + ++ L  E     DGL      + 
Sbjct: 183  QEDIEPLLKNMALHLKRLIDE---------RDEHSETIIELSEER----DGLHFLPHASS 229

Query: 890  NKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIK 949
            +         +   E  Q+   E A  K +   +     EK ++LL+ +  +     E+K
Sbjct: 230  SAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELK 289

Query: 950  ELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLE--QSHLKELEDTLQVRHIQEFEKVM 1007
             L+Q    +L D +   +  DE L  LR +   ++  +S +   ++ L   H  EF    
Sbjct: 290  RLQQENMNLLSDARSARMYRDE-LDALREKAVRVDKLESEVSRYKERL---HDIEF---- 341

Query: 1008 TDHRVSLEELKKENQQII-------NQIQESHA--EIIQEKEKQLQELKLKVSDLSDTR- 1057
              ++  +EELK++NQ ++       +Q++ + A  + + E EK+  +LK K+ D+   R 
Sbjct: 342  --YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERD 399

Query: 1058 -CKLEVELALKEAETDEI--KILLEES-----RAQQKETLKSLLEQETENLRTEISKLNQ 1109
              + ++E  ++E  T E+  K  ++ES       +Q      L E   ++L  E+++L  
Sbjct: 400  MDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTS 459

Query: 1110 ----KIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHN-- 1163
                K++  N++    + ELRT  T++  +  +  I + E+E+  L     KV  L N  
Sbjct: 460  SRLLKLEMENQSLTKTVEELRT--TVDSVEGNASKILKMEKENQRLS---KKVEILENEI 514

Query: 1164 ----QAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKL 1219
                Q+ +  +NL + +++ +++L+  +  L    + +I   E++ E + Q +   RQ+ 
Sbjct: 515  VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRS 574

Query: 1220 VSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDS 1279
              S E  R + I+K N    + +  ++KE   +   +E E  +  K LE+   K    + 
Sbjct: 575  QISAEA-RVKDIEKEN----KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE 629

Query: 1280 TRGDSSSLVAE---LQEKLQE-----EKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTN 1331
               +   L  E   LQ+K+       EK + LEQ   + +R+N +++    S        
Sbjct: 630  LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF------- 682

Query: 1332 FNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSK 1391
             N     E + KEN       +L     +  R+ + ++  S   A+L  E K+LE E  +
Sbjct: 683  KNLTFQLESLEKEN------SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736

Query: 1392 LRSS-SFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIH 1450
            L+     + + +  T  E        L  E+ R      +  +    +E+ +  ++    
Sbjct: 737  LKKGLELLKASFKKT--ERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQ 794

Query: 1451 MLSEEKQRIMLLERTLQLKEEENKRLNQ 1478
             L +  + + +  + L+  E+ENK L Q
Sbjct: 795  TLQKNLEELKISSKRLEQLEKENKSLEQ 822



 Score = 92.0 bits (227), Expect = 4e-18
 Identities = 152/690 (22%), Positives = 312/690 (45%), Gaps = 99/690 (14%)

Query: 859  LKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKH 918
            L E  QK L    NE       L+K   EN++  K ++     ++ V   + N   ++K 
Sbjct: 442  LSEAPQKSLGHEVNELTSSR--LLKLEMENQSLTKTVEELRTTVDSV---EGNASKILKM 496

Query: 919  EKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRA 978
            EKE         +Q+L +   I+ ++  + K+  Q+ + + +DL K   + ++ ++ LR 
Sbjct: 497  EKE---------NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547

Query: 979  ----ELQSLEQS--HLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESH 1032
                +++ LEQ   HL +   +L+ R      ++  + RV  ++++KEN+ +   I+E+ 
Sbjct: 548  NSERQIKILEQENEHLNQTVSSLRQR-----SQISAEARV--KDIEKENKILHESIKETS 600

Query: 1033 AEIIQ------EKEKQLQELKLK---VSDLSDTRCKLEVELALKEAETDEIKILLEESRA 1083
            +++ +      + +K+L+  K K     +L +    LE E  L + +   +KI  E+  A
Sbjct: 601  SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660

Query: 1084 QQKETLKSLLEQETENLRTEISKLN----QKIQDNNENYQVGLAELRTLMTIEKDQCISE 1139
             ++E   S LE+E   L+  +        Q      EN Q+    L     +E  +C S 
Sbjct: 661  LEQEN--SELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASM 718

Query: 1140 LISRHEEESNILKAE---LNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDE 1196
             +++ + E+  L++E   L K   L   +F+  + L+   +  Q  LD E   L++   E
Sbjct: 719  KMAQLQLENKELESEKEQLKKGLELLKASFKKTERLE---VSYQG-LDIENQRLQKTL-E 773

Query: 1197 KITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVV 1256
               ++ ++ E+ +Q+LE + Q L  + E+       K++ ++ E ++   K  + E   +
Sbjct: 774  NSNKKIQQLESELQDLEMENQTLQKNLEE------LKISSKRLEQLEKENKSLEQETSQL 827

Query: 1257 EKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEK---LQEEKAKFLE---QLEEQE 1310
            EK+  +  K  +    ++   D+T  +++  +  L+++   L +E   + E   +L+E E
Sbjct: 828  EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887

Query: 1311 KRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLI-- 1368
            K   E ++  R ++  +        L  EK++ + + NDL +KL   +++   +K+ +  
Sbjct: 888  KENKELVK--RATIDIKTLVTLREDLVSEKLKTQQMNNDL-EKLTHELEKIGLNKERLLH 944

Query: 1369 -ESLSEDRARLLEEK------KKLE---EEVSKLRSSSFVPSPY-------VATAPELYG 1411
             E  ++DR +LLE K      K LE   E+++ L +     + Y       + T  + Y 
Sbjct: 945  DEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE 1004

Query: 1412 AC------------APELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRI 1459
            A             +P + GE ++   E+ +  R    ++  ++ V+ N   L  EKQ  
Sbjct: 1005 ALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQ-- 1062

Query: 1460 MLLERTLQLKEEENKRLNQRLMSQSMSSVS 1489
              L+  L+  E +N  L  ++++    +VS
Sbjct: 1063 -ALKTQLKQLETQNNNLQAQILALQRQTVS 1091



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 126/621 (20%), Positives = 264/621 (42%), Gaps = 70/621 (11%)

Query: 865  KELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHE----- 919
            KE      E E +   L+K    +   +  L+ +LV  +   Q  +N+   + HE     
Sbjct: 877  KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG 936

Query: 920  --KEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKL---Q 974
              KE ++  +   D +   +E+ + S       LK+S EI  E +  L    +E     Q
Sbjct: 937  LNKERLLHDEQSTDDRYKLLESKLEST------LKKSLEIKEEKIAALEARLEESTNYNQ 990

Query: 975  LLRAELQSLEQSH--LKELEDTLQVRHIQ-------EFEKVMTDHRVSLEELKKENQQII 1025
             LR EL+++++++  LK+ +D  + R +Q       E  K   + + +  EL K   ++I
Sbjct: 991  QLRQELKTVKKNYEALKQRQD--EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1048

Query: 1026 NQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQ 1085
             +++ ++A +  EK    Q LK ++  L      L+ ++   + +T  ++   E++   Q
Sbjct: 1049 -EVERNNATLQAEK----QALKTQLKQLETQNNNLQAQILALQRQTVSLQ---EQNTTLQ 1100

Query: 1086 KETLKSLLEQETENLRTEISKLNQKIQ---------DNNENYQVGLAELRTLM-TIEKDQ 1135
             +  K  +E  T N ++  S +NQ  Q         + NE+      +L++L  ++ KD 
Sbjct: 1101 TQNAKLQVENSTLNSQST-SLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDH 1159

Query: 1136 CISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKD 1195
               EL+  HE +++    E   + S H       KNL+ +  +L+ + +  L    + +D
Sbjct: 1160 EKLELL--HERQAS----EYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED 1213

Query: 1196 EKITQQEEKYEAIIQNLEKDRQKLVSSQ-----EQDREQLIQKLNCEKDEAIQTALKEFK 1250
             +   + E+ + +++N  K+ + + +       E DR         ++ E +QT  K  K
Sbjct: 1214 LEKMLKVEQEKMLLEN--KNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLK 1271

Query: 1251 --LEREVVEKELLE-KVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLE 1307
              L    +E+  LE +   L+ Q  +     +   +   L+++L+  L+EE    L+Q++
Sbjct: 1272 SLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQ 1331

Query: 1308 E--QEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDK 1365
                + R   E       L   +Q  +   L   + +KE +   + D+ K       R +
Sbjct: 1332 TLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRR 1391

Query: 1366 DLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSA 1425
                 ++    +L++ KK +  E    R  S   +P  + + E +     +   +S    
Sbjct: 1392 G--NWITLKMRKLIKSKKDINRE----RQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVG 1445

Query: 1426 VETADEGRVDSAMETSMMSVQ 1446
              + ++G+     ++SM++++
Sbjct: 1446 SNSLEDGQTLGTKKSSMVALK 1466



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 91/449 (20%), Positives = 182/449 (40%), Gaps = 79/449 (17%)

Query: 1059 KLEVELALKEAETD------EIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQ 1112
            KLE +   K+   D       + IL+ + +   +ETL+ L+     N+          I 
Sbjct: 58   KLESQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVL---------II 108

Query: 1113 DNNENYQVGLAELRTLMTI---------EKDQCISELISRHEEESNILKAELNKVTSLHN 1163
              N   + G  E++ L+ +         +K++ I  +     +    + A + +VT  HN
Sbjct: 109  GKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVT--HN 166

Query: 1164 QAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQ 1223
            Q         E + +LQ    +++S             +E  E +++N+    ++L+  +
Sbjct: 167  Q---------ENVFDLQWMEVTDMS-------------QEDIEPLLKNMALHLKRLIDER 204

Query: 1224 EQDREQLIQKLNCEKD--EAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTR 1281
            ++  E +I+ L+ E+D    +  A    +        +  E  +HL  ++A         
Sbjct: 205  DEHSETIIE-LSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELA--------- 254

Query: 1282 GDSSSLVAELQEKLQEEKAKFL------EQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTV 1335
             D+ + +  L+++L+E+  + L      EQ+E + KR  +E  N+ +   + +       
Sbjct: 255  -DAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELD 313

Query: 1336 LTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSS 1395
              REK  + + +     + K  +   E  K  +E L ED   LLE K  LE+++   R+ 
Sbjct: 314  ALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRAR 373

Query: 1396 S----FVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHM 1451
            S     +    +    +L+     E+  + DR  +E   E  +   M     S+ E++H+
Sbjct: 374  SDKLHELEKENLQLKAKLHDM---EMERDMDRKKIEELMEENMTLEM-AQKQSMDESLHL 429

Query: 1452 LSEEKQRIMLLERTLQLKEEENKRLNQRL 1480
              E +Q    + RT +L E   K L   +
Sbjct: 430  GWELEQ----ISRTSELSEAPQKSLGHEV 454


>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
          Length = 1979

 Score =  102 bits (255), Expect = 2e-21
 Identities = 203/1008 (20%), Positives = 414/1008 (41%), Gaps = 130/1008 (12%)

Query: 571  DCELPDISLKDLQFLQSFCPSEVQPFLRVPLLC-DFEPLHQ--HVLALHNLVKAAQSLDE 627
            + ELPD   K+++ + +   SE +   R+  LC D E  H+   +            L +
Sbjct: 46   EAELPDSRTKEIEAIHAILRSENE---RLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQ 102

Query: 628  MSQTITDLLSEQKASVSQTSPQSASSPRMESTAGITTTTSPRT--------PPPLTVQD- 678
                I+ L + Q A   Q     +++  + S AG+  TT+  +        P      D 
Sbjct: 103  KEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDM 162

Query: 679  PLCPAVCPLEELSPDSIDAHTFDFETIPHPNIEQTIHQVSLDLDSLAESPESDFMSAVNE 738
                 +   +E++  S +    + E     +I QT      D      S +S+     N 
Sbjct: 163  DFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTD-----NSDQSEICKLQN- 216

Query: 739  FVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDTNVCGKEDFGDHTSLNVQL 798
             +I+E   + +   D    EM       SV+     +++ + +   +E+  D+     +L
Sbjct: 217  -IIKELKQNRSQEIDDHQHEM-------SVLQNAHQQKLTEISRRHREELSDYEERIEEL 268

Query: 799  ERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEIT 858
            E   ++ Q     I+T    +   +  +Q  Q +   S K    ++  + +K+K   +  
Sbjct: 269  EN--LLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTK----KMEQLEDKIKDINKKL 322

Query: 859  LKEKHQKELLSLKNEYEG-KLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVK 917
               ++ +++L  + E    +   +++E E  + +  KL+   V   + +  K+   A   
Sbjct: 323  SSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSA 382

Query: 918  HEKEAVICLQ--NEKDQKLLEMENIMHSQNCEIKELKQSREI-VLEDLKKLHVENDEKLQ 974
              +E     Q  ++ + +++ + ++    +     LK    I VLE  K L  +  E+LQ
Sbjct: 383  SVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQ 442

Query: 975  LLRAELQSLEQ-------------SHLKELEDTLQVRHIQEFEKVMTDHRV---SLEELK 1018
            +   +L +  +             S L +L   L+ +  QE  + +++       +EEL 
Sbjct: 443  MSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKE-QELNQSISEKETLIAEIEELD 501

Query: 1019 KENQQ-------IINQIQESHAE---IIQEKEKQLQELKLKVSDLSDTRCKLEVELALKE 1068
            ++NQ+       I +Q+ +   E   II + ++ L + K +V  L D +  +      KE
Sbjct: 502  RQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDIT-----KE 556

Query: 1069 AETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTL 1128
             +  + K++  E         K  LE + ENL   + +LN K Q++N + Q    EL+  
Sbjct: 557  LDVQKEKLIQSEVALNDLHLTKQKLEDKVENL---VDQLN-KSQESNVSIQKENLELK-- 610

Query: 1129 MTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELS 1188
                      E I ++EEE + ++ EL +  +  + +   +  LKE+  E+++ L   LS
Sbjct: 611  ----------EHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRN-LKQNLS 659

Query: 1189 ALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQ------KLNCEKDEAI 1242
             LE        Q  E  + +  +++ + +KLV + E  R QL +      +L+ EK+  +
Sbjct: 660  ELE--------QLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIV 711

Query: 1243 QTA-LKEFKLEREV--VEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEK 1299
            +T  +++ ++E E+   +K LLE+    E  I +     +    +  L  E   KL ++K
Sbjct: 712  ETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK 771

Query: 1300 AKFLEQLE---EQEKRKNEEMQNVRTSLIAEQQT-----NFNTVLTREKMRKENIINDLS 1351
               + +L+   EQ    ++E ++V +S + EQ+      N   +   +   + + + +  
Sbjct: 772  DMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEEL 831

Query: 1352 DKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYG 1411
            DK    +++ E  +  IE        + EE   L+EE+ +LR              E   
Sbjct: 832  DKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLR--------------EEQS 877

Query: 1412 ACAPELPGESDRSAVETADE-GRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTL--QL 1468
              AP    ++  S  E A E  ++++  E     ++ +  ++ ++ Q  M L ++L  Q 
Sbjct: 878  RTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQK 937

Query: 1469 KEEENKRLNQRLMSQSMSSVSSRHSEKIAIRDFQVGDLVLIILDERHD 1516
            KE +  R     M+ + + +     E+I      +  +   + +ER D
Sbjct: 938  KEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQD 985



 Score = 91.3 bits (225), Expect = 7e-18
 Identities = 151/772 (19%), Positives = 315/772 (40%), Gaps = 125/772 (16%)

Query: 826  VQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKH--QKELLSLKNEYEGKLDGLIK 883
            +Q+E   +S +L+   + +R  IE+   SL    +E +  Q+EL  L+ E          
Sbjct: 827  LQEELDKYSQALRKNEI-LRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADP 885

Query: 884  ETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHS 943
            +T ++  ++     +L  ++E L+ +      +KH ++ +     +++Q  +++   +  
Sbjct: 886  KTLDSVTELASEVSQLNTIKEHLEEE------IKHHQKII----EDQNQSKMQLLQSLQE 935

Query: 944  QNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDT--------- 994
            Q  E+ E +   E +     +L +E DE+++ L+  ++ ++    +E +D          
Sbjct: 936  QKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQ 995

Query: 995  -----------------LQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESH----- 1032
                             L     +   K + +  + ++ L ++N  +  QI +       
Sbjct: 996  ETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVG 1055

Query: 1033 --AEIIQEKEKQLQELKLKVSDLSDTR--CKLEVELALKEAETDEIKILLEESRAQQKET 1088
               +IIQ+K+ ++Q L  ++S  S T+    L+ +L     E +++  +L E        
Sbjct: 1056 KLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKT------ 1109

Query: 1089 LKSLLEQETENLRTEISKLNQ----------KIQDNNENYQVGLAELRTLMTIEKDQCIS 1138
                  +E  +L+TE  K+            K+QD N+            M  E  Q +S
Sbjct: 1110 ------RENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLS 1163

Query: 1139 ELISRHEEESNILKAELN------KVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALER 1192
             +I   + E + L  +        + +S  N+A  +  N  E++++ + KL  ++  +E 
Sbjct: 1164 RIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEE 1223

Query: 1193 QKDEKITQQEEKYEAIIQNLEK----DRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKE 1248
             K + +T  +       Q  E+      Q LV S    + Q+      +  E  +T LK 
Sbjct: 1224 WKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKN 1283

Query: 1249 FKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFL----- 1303
            F  E   V+  + +     +  + K   I      +S L  +  E L+  K++ L     
Sbjct: 1284 FGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSE 1343

Query: 1304 ---EQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKE-----NIINDLSDKLK 1355
               ++LEE  K   E+   +RT      + + +   T E  RKE     + I  L +K +
Sbjct: 1344 LLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEK-Q 1402

Query: 1356 STMQQQERDKDL--------IESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAP 1407
              +Q+  ++KDL        + S +E+    + E + L + V+ L+    +    +    
Sbjct: 1403 DVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIG--- 1459

Query: 1408 ELYGACAPELPGESDRSAVET--ADEGRVDSAMETSM---MSVQENIHMLSEEKQRIMLL 1462
                    +L GE+++  VET    E    +  ET+M   M ++E        K++ +  
Sbjct: 1460 --------KLKGENEK-IVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAF 1510

Query: 1463 ERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEKIAIRDFQVGDLVLIILDER 1514
            E+   LKE+E  +  +  ++Q +++V S   + +  +  Q  D V++ L ++
Sbjct: 1511 EQL--LKEKEQGKTGE--LNQLLNAVKSMQEKTVVFQ--QERDQVMLALKQK 1556



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 156/800 (19%), Positives = 327/800 (40%), Gaps = 130/800 (16%)

Query: 709  NIEQTIHQVSLDLDSLAESPESDFMSAVNEFVIE----ENLSSPNPISDPQSPEMMV--- 761
            ++++TI Q+   L    +  ++D      E  ++    EN S  + +S  ++  ++    
Sbjct: 967  SLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIK 1026

Query: 762  -ESLYSSVINAIDSRRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLC 820
               L   ++N  +    +  +   K++ G  T + +Q +   + A  +  S  +  +D+ 
Sbjct: 1027 ERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQI-IQQKDLEIQALHARISSTSHTQDVV 1085

Query: 821  HFRTFVQ-------------KEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKEL 867
            + +  +Q              E+   ++ LK    ++ +I+   + +L I L+++++K  
Sbjct: 1086 YLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAAL-IKLQDENKK-- 1142

Query: 868  LSLKNEYEGKLDGLIKETEENENKIKKLKG-ELVCLEEVLQN-----------------K 909
              L   +E     + +ET +N ++I + K  E+  L +  Q                   
Sbjct: 1143 --LSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVN 1200

Query: 910  DNEFALVKHE----KEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKL 965
             N+F  +  E    K+ V  ++  K Q +  ++N+ H      +EL Q +  VL D    
Sbjct: 1201 SNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDS--- 1257

Query: 966  HVENDEKLQL-LRAELQSLEQSHLKEL---EDTLQVRHI--------------------- 1000
              +N+ KLQ+     +QS EQ+  K     ++  QV+H                      
Sbjct: 1258 --DNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQ 1315

Query: 1001 QEFEKVMTDH-----RVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSD 1055
                 ++T       R S  E+  E+ +++ Q  E   + +QEK+  ++ L+     LSD
Sbjct: 1316 LSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSD 1375

Query: 1056 T-RCKLEVELALKEAETDEIKILLEESRAQQKETLKS--LLEQETENLRTEISKLNQKIQ 1112
            +     E+E    E    EIK L E+    QK   +   L++ +++ L +       K+ 
Sbjct: 1376 SIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVN 1435

Query: 1113 DNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNL 1172
            +N    Q        ++ +E D  I +L   +E+     + +  +  +L     +    L
Sbjct: 1436 ENELLRQAVTNLKERILILEMD--IGKLKGENEKIVETYRGKETEYQALQETNMKFSMML 1493

Query: 1173 KEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQK-LVSSQEQDREQLI 1231
            +E+  E  S  +  L A E+   EK   +  +   ++  ++  ++K +V  QE+D+  L 
Sbjct: 1494 REKEFECHSMKEKAL-AFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLA 1552

Query: 1232 QKLNCEKDEAIQTAL-----KEFKLEREVV-----------------------EKELLEK 1263
             K    ++ A+Q  +     KEF+  +E+                        E +L +K
Sbjct: 1553 LKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKK 1612

Query: 1264 VKHLENQ-IAKSPAIDSTRGDSSSLVAELQEKL------QEEKAKFLEQLEEQEKRKNEE 1316
            V  LE + ++ S A+++    +S  V  LQE+L      ++E A  L   +EQ K+    
Sbjct: 1613 VTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALS 1672

Query: 1317 MQNVRTSLIAEQQTNFNTVLTREKMRKENIINDL---SDKLKSTMQQQERDKDLIESLSE 1373
            + N++  L   QQ     + + E  +++ +I +    ++ L+  +   +   D   +  +
Sbjct: 1673 LANLQMVLEHFQQEE-KAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALD 1731

Query: 1374 DRARLLEEKKKLEEEVSKLR 1393
              +RL E+    EE++ +L+
Sbjct: 1732 SASRLTEQLDVKEEQIEELK 1751



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 95/454 (20%), Positives = 209/454 (46%), Gaps = 82/454 (18%)

Query: 843  EIRNIIEKVKCSLEITLKEKHQ-KELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVC 901
            E+R  +++   ++    +  H+  + ++  +E E K      E E+ +++IK+LK +   
Sbjct: 1351 ELRKSLQEKDATIRTLQENNHRLSDSIAATSELERK------EHEQTDSEIKQLKEKQDV 1404

Query: 902  LEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLED 961
            L+++L+ KD    L+K + + ++        K+ E E +  +    +  LK+   I+  D
Sbjct: 1405 LQKLLKEKD---LLIKAKSDQLLSSNENFTNKVNENELLRQA----VTNLKERILILEMD 1457

Query: 962  LKKLHVENDEKLQLLRA---ELQSLEQSHLKELEDTLQVRHIQEFE-KVMTDHRVSLEEL 1017
            + KL  EN++ ++  R    E Q+L+++++K    ++ +R  +EFE   M +  ++ E+L
Sbjct: 1458 IGKLKGENEKIVETYRGKETEYQALQETNMKF---SMMLRE-KEFECHSMKEKALAFEQL 1513

Query: 1018 KKENQQ--------IINQIQESHAE-IIQEKEKQLQELKLKVSDLSDTRCKLEVE-LALK 1067
             KE +Q        ++N ++    + ++ ++E+    L LK   + +T  + EV+ L  K
Sbjct: 1514 LKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDK 1573

Query: 1068 EAETDEI-----KILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDN-----NEN 1117
            E  +++        LLE   +  +E L +  E     LR +++ L +K+  +     N +
Sbjct: 1574 EFRSNQELERLRNHLLESEDSYTREALAA--EDREAKLRKKVTVLEEKLVSSSNAMENAS 1631

Query: 1118 YQVG-----LAELRTLMTIEKDQCISELISRHE---------------------EESNIL 1151
            +Q       L E   +++ ++D+   +L    E                     EE  + 
Sbjct: 1632 HQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMY 1691

Query: 1152 KAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALE------------RQKDEKIT 1199
             AEL K   L  +  +  +NL+ ++I LQ  LD   +AL+             ++ E++ 
Sbjct: 1692 SAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELK 1751

Query: 1200 QQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQK 1233
            +Q E  + ++ +++K    L +S E   ++++ +
Sbjct: 1752 RQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMR 1785



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 92/443 (20%), Positives = 185/443 (41%), Gaps = 70/443 (15%)

Query: 1071 TDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMT 1130
            T+E++  L +SR ++ E + ++L  E E L+   + L +K       ++    +++   T
Sbjct: 42   TEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEK-------HEASEIQIKQQST 94

Query: 1131 IEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSAL 1190
              ++Q     + + E E + LKA               +  L++Q+++LQS   S  S  
Sbjct: 95   SYRNQ-----LQQKEVEISHLKAR--------------QIALQDQLLKLQSAAQSVPSGA 135

Query: 1191 ---ERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDRE--QLIQKLNCEKDEAIQTA 1245
                             + +   + + D   ++SSQ++       + +L  E       A
Sbjct: 136  GVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIA 195

Query: 1246 LKEFKLEREVVEKELLEKVKHLENQIA--KSPAIDSTRGDSSSLVAELQEKLQEEKAKFL 1303
                    +  ++  + K++++  ++   +S  ID  + + S L    Q+KL E   +  
Sbjct: 196  QTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHR 255

Query: 1304 EQLEEQEKRKNEEMQN---------VRTSL--IAEQQTNFNTVL------TREKMRKENI 1346
            E+L + E+R  EE++N         + T L  I E Q     +       T++  + E+ 
Sbjct: 256  EELSDYEERI-EELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDK 314

Query: 1347 INDLSDKLKSTMQQQERDKDLI----ESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPY 1402
            I D++ KL S     E D+D++    E L+ ++ +++EE + L+ E SKL+ S+   S  
Sbjct: 315  IKDINKKLSSA----ENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDT 370

Query: 1403 VATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEE----KQR 1458
            +     +       L   +    V    +   D+  E   +S     + L+E+    K R
Sbjct: 371  MTEKERI-------LAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMR 423

Query: 1459 IMLLERTLQLKEEENKRLNQRLM 1481
            I +LE+   L  +E + L   L+
Sbjct: 424  IEVLEKEKSLLSQEKEELQMSLL 446


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  102 bits (253), Expect = 4e-21
 Identities = 161/748 (21%), Positives = 344/748 (45%), Gaps = 80/748 (10%)

Query: 806  QDSHFSIQTI---KEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEK 862
            Q+SH  ++++   K+DL   +  +Q E      ++K    +     E++K +    LKE+
Sbjct: 1431 QESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVA-HCCLKEQ 1489

Query: 863  HQ--KELLSLKNEYEGKLDGLIKETE----ENENKIKKL--KGELVCLEEV--LQNKDNE 912
             +   EL    +E E ++  + K+ E    + +NKI+++  K E   ++++  +Q K NE
Sbjct: 1490 EETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNE 1549

Query: 913  FALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEK 972
                K  ++A        + K+LE+ N +     EI+ + + +E +    + L +E D+ 
Sbjct: 1550 LKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQL 1609

Query: 973  LQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKK--ENQQI-INQIQ 1029
             +  +  +  +++S  KE +  L++  + E ++ M +    +E LK+  E Q++ +  I+
Sbjct: 1610 KENTKEIVAKMKESQEKEYQ-FLKMTAVNETQEKMCE----IEHLKEQFETQKLNLENIE 1664

Query: 1030 ESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETL 1089
              +  + Q   + L+E++    +  D R    VE  LK  E D++K  L E+  +  E  
Sbjct: 1665 TENIRLTQILHENLEEMRSVTKERDDLR---SVEETLK-VERDQLKENLRETITRDLEKQ 1720

Query: 1090 KSLL--------EQET-ENLRTEISKLNQKIQDNNENYQVGLAELRTL-MTIEKDQCISE 1139
            + L          QET + LR  +S+   +I +  ++ +     L+   + I+++  I+ 
Sbjct: 1721 EELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAH 1780

Query: 1140 LISRHEEES-----NILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQK 1194
            +  + ++E+      I+  + +K++++          L+E+I EL++   +E   +  +K
Sbjct: 1781 MHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKA---NEHQLITLKK 1837

Query: 1195 DEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKE------ 1248
            D   TQ++      ++   KD+   +S  E +   L QKL+ E  E +++ +KE      
Sbjct: 1838 DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLH-ENLEEMKSVMKERDNLRR 1896

Query: 1249 ----FKLEREVVEKELLE-KVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEK---- 1299
                 KLER+ +++ L E K + LE Q     A   ++ +    V +L+EK+ E+     
Sbjct: 1897 VEETLKLERDQLKESLQETKARDLEIQQELKTARMLSK-EHKETVDKLREKISEKTIQIS 1955

Query: 1300 --AKFLEQLEEQEKRKNEEMQNVRTSLIAEQQ---TNFNTVLTREKMRKENIINDLSDKL 1354
               K L++ +++ ++K +E+Q     L+  ++    +   +   E+++K+    +LS + 
Sbjct: 1956 DIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQ- 2014

Query: 1355 KSTMQQQERDKDLIESLSEDR--ARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGA 1412
               M   +  K L ESL E R  A+  +E ++++E +   R        ++AT  E+   
Sbjct: 2015 SVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQ------FIATLREMIAR 2068

Query: 1413 CAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLER---TLQLK 1469
                   + ++  +    +   +S  E     ++E +   SE       L R    L+ +
Sbjct: 2069 DRQNHQVKPEKRLLSDGQQHLTESLRE-KCSRIKELLKRYSEMDDHYECLNRLSLDLEKE 2127

Query: 1470 EEENKRLNQRLMSQ-SMSSVSSRHSEKI 1496
             E  K L+ R+ +  S+  + ++H EK+
Sbjct: 2128 IEFQKELSMRVKANLSLPYLQTKHIEKL 2155



 Score = 95.9 bits (237), Expect = 3e-19
 Identities = 162/773 (20%), Positives = 346/773 (44%), Gaps = 145/773 (18%)

Query: 794  LNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKC 853
            L   LE  + + Q+    ++ ++E L   R  ++ +  D  N    T  ++RN +E +K 
Sbjct: 917  LQQTLEEVKTLTQEKD-DLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQ 975

Query: 854  SLEI--TLKEKHQKELL----------SLKNEYEGKLDGLIKETEENENKIKKLKGELVC 901
              E   TLK K  +E+             K+E++ K+ G+ K+ +      + L  ++  
Sbjct: 976  HQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADV-- 1033

Query: 902  LEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLED 961
                   KDNE   +  ++  +  L  EK++    +E+++  +     +LK++ E+ +E+
Sbjct: 1034 -------KDNE---IIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIEN 1083

Query: 962  LKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKEN 1021
             ++L +  DE  +  + E+ + E++H  + E  L  R      +V    +   ++L+++ 
Sbjct: 1084 QEELRLLGDELKK--QQEIVAQEKNHAIKKEGELS-RTCDRLAEVEEKLKEKSQQLQEKQ 1140

Query: 1022 QQIINQIQESHAEIIQEKEKQLQELK--LKVSDLSDTRCKLE-VELALKEAET-DEIKIL 1077
            QQ++N +QE  +E +Q+K  +++ LK  LK  +L+    + E +ELA K  E  +E+K +
Sbjct: 1141 QQLLN-VQEEMSE-MQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSI 1198

Query: 1078 LEESRAQQKETLKSLLEQETENLRTEISKLNQK-IQDNNE---------NYQVGLAELRT 1127
             +E R   KE  KS  E E ++LR  I ++    +Q   E          +Q  + ELR 
Sbjct: 1199 TKE-RKVLKELQKS-FETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRR 1256

Query: 1128 LMTIEKDQCIS-------------ELISRHEE--------ESNILKAELNKVTSLHNQA- 1165
             ++ +  Q I+             E+   HEE        E +  +  +N++  L  Q+ 
Sbjct: 1257 SVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQST 1316

Query: 1166 ---------FEIEK-NLKEQIIELQSKLDSELSALERQKDEKITQQEE---KYEAIIQNL 1212
                      E+E+  L E+  E Q     E+ +L +++D   T +E    K++ + +++
Sbjct: 1317 TKDSTTLARIEMERLRLNEKFQESQ----EEIKSLTKERDNLKTIKEALEVKHDQLKEHI 1372

Query: 1213 EKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREV---VEKELLEKVKHLEN 1269
             +   K+  SQ +  + L  K    +   I + +++FK +      +E E+L   K L+ 
Sbjct: 1373 RETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQE 1432

Query: 1270 QIAKSPAIDSTRGDSSSLVA-------ELQEKLQEEKAKFLEQLEEQE------KRKNEE 1316
               +  ++   + D   L         +L+E ++E  AK LE  EE +      K + E 
Sbjct: 1433 SHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEET 1492

Query: 1317 MQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQ--QERDKDLIESLSED 1374
            +  +R +L +E++T  +T+        +  +  ++DKL++ +Q+  ++ ++  I+ +SE 
Sbjct: 1493 INELRVNL-SEKETEISTI--------QKQLEAINDKLQNKIQEIYEKEEQFNIKQISEV 1543

Query: 1375 RARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRV 1434
            + ++ E K+  E   +K                                SA+++ +   +
Sbjct: 1544 QEKVNELKQFKEHRKAK-------------------------------DSALQSIESKML 1572

Query: 1435 DSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSS 1487
            +  +   +   QE I ++ +EK+ +  ++  LQ++ ++ K   + ++++   S
Sbjct: 1573 E--LTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKES 1623



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 125/568 (22%), Positives = 253/568 (44%), Gaps = 103/568 (18%)

Query: 860  KEKHQKELLSLKNEYEGKL---DGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALV 916
            +E  + EL SL+ +Y+  +   + L  E EE E K+K+            +N  +EF  +
Sbjct: 493  QENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKE------------KNDLDEFEAL 540

Query: 917  KHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLL 976
            + +         +KDQ   EM+ I    N  +K L +  E+  +DL+    E   K++LL
Sbjct: 541  ERK--------TKKDQ---EMQLIHEISN--LKNLVKHAEVYNQDLEN---ELSSKVELL 584

Query: 977  RAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEII 1036
            R +     +  +K+L++ +     Q+ E +  D   SLE ++   Q            + 
Sbjct: 585  REK-----EDQIKKLQEYIDS---QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALD 636

Query: 1037 QEKEKQLQ-----ELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKS 1091
             ++E         ELK K+ +L+ T          K+ E D   I L +S+ + K+ ++ 
Sbjct: 637  AKRESAFLRSENLELKEKMKELATT---------YKQMEND---IQLYQSQLEAKKKMQV 684

Query: 1092 LLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISEL---ISRHEEES 1148
             LE+E ++   EI+KL   I         G      L  +E +  I++L   +++  EE+
Sbjct: 685  DLEKELQSAFNEITKLTSLID--------GKVPKDLLCNLELEGKITDLQKELNKEVEEN 736

Query: 1149 NILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDE---KITQQEEKY 1205
              L+ E+  ++ L +   E+E+  KE    +Q K + EL  +  +KD+   ++  +E + 
Sbjct: 737  EALREEVILLSELKSLPSEVERLRKE----IQDKSE-ELHIITSEKDKLFSEVVHKESRV 791

Query: 1206 EAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVK 1265
            + +++ + K +  L ++Q         K   ++ +  +T   +F+ + ++V +E     +
Sbjct: 792  QGLLEEIGKTKDDLATTQSN------YKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQ 845

Query: 1266 HLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLI 1325
             + N   ++   DS+ G   + ++   ++LQE+  +  E+L E E+ K +      T   
Sbjct: 846  EIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQT 905

Query: 1326 AEQQTNFNT-----------VLTREK-----------MRKENIINDLSDKLKSTMQQQER 1363
             E++    T            LT+EK           + ++ + +D+ D +   +  QE+
Sbjct: 906  VEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQ 965

Query: 1364 DKDLIESLSEDRARLLEEKKKLEEEVSK 1391
             ++ +ESL + +  +   K K+ EEVS+
Sbjct: 966  LRNALESLKQHQETINTLKSKISEEVSR 993



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 164/800 (20%), Positives = 336/800 (42%), Gaps = 121/800 (15%)

Query: 688  EELSPDSIDAHTFDFETIPHPNIEQTIHQVSLDLDSLAESPESDFMSAVNEFVIEENLSS 747
            ++L+ ++I+        I H N+E+ +  V+ + D L    E+     V    ++ENL  
Sbjct: 1656 QKLNLENIETENIRLTQILHENLEE-MRSVTKERDDLRSVEET---LKVERDQLKENLRE 1711

Query: 748  PNPISDPQSPEMMVESLYSSV-------INAIDSRRMQDTNVCGKEDFGDHTSLNVQLER 800
                   +  E+ +  ++          +  I S +  + +   K+    + +L  Q  +
Sbjct: 1712 TITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLK 1771

Query: 801  CRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSN---SLKCTAVEIRNIIEKVKCSLE- 856
             +   + +H  ++  +E +   R  V ++    SN    L+ +  +++  I+++K +   
Sbjct: 1772 IQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQ 1831

Query: 857  -ITLK------EKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNK 909
             ITLK      +K   E+  LK + + +   L K   EN N  +KL   L  ++ V++ +
Sbjct: 1832 LITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKER 1891

Query: 910  DNEFAL---VKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQS----------RE 956
            DN   +   +K E++ +     E   + LE++  + +     KE K++          + 
Sbjct: 1892 DNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKT 1951

Query: 957  IVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDT----LQVRHIQEFEKVMTDHRV 1012
            I + D++K   ++ ++LQ    ELQ  E   L+  ED      ++  +++ +K      +
Sbjct: 1952 IQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNL 2011

Query: 1013 SLEELKKENQQIINQIQESHAEI--IQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAE 1070
            S++ ++ +N Q+  ++ ES  EI  + ++  +L+ +K  +    D       E+  ++ +
Sbjct: 2012 SMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQ 2071

Query: 1071 TDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMT 1130
              ++K         +K  L    +  TE+LR + S++ + ++  +E         R  + 
Sbjct: 2072 NHQVK--------PEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLD 2123

Query: 1131 IEKDQCISELISRHEEESNILKAELNKV---TSLHNQAFEIEKNLKEQIIELQSKLDSEL 1187
            +EK+      I   +E S  +KA L+     T    + F   +    +   +  KL   L
Sbjct: 2124 LEKE------IEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVL 2177

Query: 1188 SALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQ--EQD-----REQLIQKLNCEKDE 1240
            S + + K+E+     +     I  +EK ++ L+  Q  +QD     RE    KLN   D 
Sbjct: 2178 SYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDL 2237

Query: 1241 AIQTALKEF--------KLEREVVEKELLEKVKHLENQIAKSPAIDSTRGD--------- 1283
             I+  LK+F        K E + V     E  + LE  +     I+  +           
Sbjct: 2238 HIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRIC 2297

Query: 1284 ------SSSLVAELQEKLQ-EEKAKFLEQLEEQE----KRKNEEM----QNVRTSLIAEQ 1328
                  ++ ++A + E  + EE++  + +  EQ+    K KNE++    Q ++TSL +  
Sbjct: 2298 QVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGA 2357

Query: 1329 QTNFN-------------TVLTREKMRK-ENIINDLSD-------KLKSTMQQQERDKDL 1367
            Q N               T LT EK+R+ EN +++  +       K+    ++ E   D+
Sbjct: 2358 QVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDI 2417

Query: 1368 IESLSEDRARLLEEKKKLEE 1387
            I  L   +A++ E  K LE+
Sbjct: 2418 IAKL---QAKVHESNKCLEK 2434



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 136/587 (23%), Positives = 272/587 (46%), Gaps = 80/587 (13%)

Query: 843  EIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKI------KKLK 896
            +I N+   +  S  +TL+++ + +         GK++ +      ++  I      K  K
Sbjct: 393  KIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHK 452

Query: 897  GELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSRE 956
              +  L E+ ++  +E  +  +  + +  ++     KLL  ENI      E+  L+   +
Sbjct: 453  LSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENI----ESELNSLRADYD 508

Query: 957  IVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVS-LE 1015
             ++ D ++L  E +E       EL+  E++ L E E     R  ++ +++   H +S L+
Sbjct: 509  NLVLDYEQLRTEKEEM------ELKLKEKNDLDEFEAL--ERKTKKDQEMQLIHEISNLK 560

Query: 1016 ELKKE----NQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAET 1071
             L K     NQ + N++  S  E+++EKE Q+++L+  +        K+++  +L+  E 
Sbjct: 561  NLVKHAEVYNQDLENELS-SKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIED 619

Query: 1072 D-EIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMT 1130
              ++K  L ++     ET+    ++E+  LR+E  +L +K+++    Y+    ++   + 
Sbjct: 620  PKQMKQTLFDA-----ETVALDAKRESAFLRSENLELKEKMKELATTYK----QMENDIQ 670

Query: 1131 IEKDQCISELISRHEEESNILKA--ELNKVTSLHN----QAFEIEKNLKEQIIELQSKLD 1184
            + + Q  ++   + + E  +  A  E+ K+TSL +    +       L+ +I +LQ +L+
Sbjct: 671  LYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELN 730

Query: 1185 SELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQT 1244
             E+   E  ++E I   E K  ++   +E+ R+++     QD+ + +  +  EKD     
Sbjct: 731  KEVEENEALREEVILLSELK--SLPSEVERLRKEI-----QDKSEELHIITSEKD----- 778

Query: 1245 ALKEFKLEREVVEKELLEKVKHLENQIAKSPA-IDSTRGDSSSLVAELQEKL---QEEKA 1300
                 KL  EVV KE   +V+ L  +I K+   + +T+ +  S   E Q       + + 
Sbjct: 779  -----KLFSEVVHKE--SRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQ 831

Query: 1301 KFLEQLEEQEKRKNE------EMQNVRTSLIA-EQQTNFNTVLTREKMRKE----NIIND 1349
            K+   LEE E+   E      E Q   +SL A + + ++ T   +EK R+     N +  
Sbjct: 832  KYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQ 891

Query: 1350 LSDKLK---STMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLR 1393
            L ++L+   ST+Q  ER+K LI   +E   + LEE K L +E   L+
Sbjct: 892  LKEQLENRDSTLQTVEREKTLI---TEKLQQTLEEVKTLTQEKDDLK 935



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 125/630 (19%), Positives = 257/630 (40%), Gaps = 98/630 (15%)

Query: 938  ENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAE--LQSLEQSHLKELEDTL 995
            E ++     EI +LK+  E V  + +   +E D+  QLL  +  LQ ++   ++ L   L
Sbjct: 342  EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML 401

Query: 996  QVRH---IQEFEKVMTDHRVS-----LEELKKENQ--------QIINQIQESHAEIIQEK 1039
                   +Q+  K     RV+     + ++K  N          I  +  +    +++E 
Sbjct: 402  VTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREI 461

Query: 1040 EKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETEN 1099
            ++ +       S+  DT  ++E   A K    + I+  L   RA         L  + E 
Sbjct: 462  DESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDN-----LVLDYEQ 516

Query: 1100 LRTEISKLNQKIQDNNENYQVGLAELRT-----LMTIEKDQCISELISRHEEESNILKAE 1154
            LRTE  ++  K+++ N+  +    E +T     +  I +   +  L+   E  +  L+ E
Sbjct: 517  LRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENE 576

Query: 1155 LNKVTSLHNQAFEIEKNLKEQIIE-----LQSKLDSELSALERQKDEKITQQEEKYEAI- 1208
            L+    L  +  +  K L+E I       ++  L   L ++E  K  K T  + +  A+ 
Sbjct: 577  LSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALD 636

Query: 1209 ---------IQNLE-KDRQKLVSSQEQDREQLIQ----------KLNCEKDEAIQTALKE 1248
                      +NLE K++ K +++  +  E  IQ          K+  + ++ +Q+A  E
Sbjct: 637  AKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNE 696

Query: 1249 F---------KLEREVV-EKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEE 1298
                      K+ ++++   EL  K+  L+ ++ K    +    +   L++EL+    E 
Sbjct: 697  ITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSE- 755

Query: 1299 KAKFLEQLEEQEKRKNEEMQNVRT------SLIAEQQTNFNTVLTREKMRKENIINDLSD 1352
                +E+L ++ + K+EE+  + +      S +  +++    +L      K+++    S+
Sbjct: 756  ----VERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSN 811

Query: 1353 KLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGA 1412
              KST Q+ +  K L     +    +LEE +++ +E+  L       S          GA
Sbjct: 812  -YKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNL-------SKEAQKFDSSLGA 863

Query: 1413 CAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEE 1472
               EL  ++     +T +              VQE ++ + + K+++   + TLQ  E E
Sbjct: 864  LKTELSYKTQELQEKTRE--------------VQERLNEMEQLKEQLENRDSTLQTVERE 909

Query: 1473 NKRLNQRLMSQSMSSVSSRHSEKIAIRDFQ 1502
               + ++L  Q++  V +   EK  ++  Q
Sbjct: 910  KTLITEKL-QQTLEEVKTLTQEKDDLKQLQ 938


>gi|118498356 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score =  101 bits (252), Expect = 5e-21
 Identities = 142/625 (22%), Positives = 285/625 (45%), Gaps = 93/625 (14%)

Query: 849  EKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVC------- 901
            ++  C +++ LKEK      +LK   +G+L  LI + +E +  +  +K +          
Sbjct: 299  DEALCVVDL-LKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQ 357

Query: 902  -LEEVLQNKDNEFALVKHEKEAVICLQNEKD--------------QKLLEMENIMHSQNC 946
              +E++  K+    ++   K+ +  L+ E +              Q  ++ + +      
Sbjct: 358  LTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEA 417

Query: 947  EIKELKQS----REIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQE 1002
            EI  LKQ     R+ V     +L  +   +L  LR +   L  + L E    LQ   +Q+
Sbjct: 418  EIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARL-VNELTEKTGKLQQEEVQK 476

Query: 1003 --FEKVMTDHRVSLEELKKENQQIINQIQESHAE----------IIQEKEKQLQELKLKV 1050
               E+  T  +V L+E ++  +++ + I++  AE              KE ++Q L  K+
Sbjct: 477  KNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKL 536

Query: 1051 SDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQK 1110
            +D   ++ +LE  L ++  E+++ ++  EES   Q   ++ +LEQ  E L+ +I + + +
Sbjct: 537  TDTLVSKQQLEQRL-MQLMESEQKRVNKEESLQMQ---VQDILEQ-NEALKAQIQQFHSQ 591

Query: 1111 IQDNNENYQVGLAELRTLMTIEKDQCISE-----------LISRHEEESNI------LKA 1153
            I    +     LAE    +  EKD+ I +           L S+ EE  +I      LKA
Sbjct: 592  IA--AQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKA 649

Query: 1154 ELNKVTSLHNQ----AFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAI- 1208
            E+ K+ +L N+    A E+EK  +   ++     D ++  LE Q   +I+ + E+++ + 
Sbjct: 650  EVQKLQALANEQAAAAHELEKMQQSVYVK-----DDKIRLLEEQLQHEISNKMEEFKILN 704

Query: 1209 -----IQNLEKDRQKLVSSQ-EQDREQLIQKLNCEKDEAIQTA--LKEFKLEREVVEKEL 1260
                 +++  +  Q LVS Q  +D  + ++K   EKDE ++T   L E  L +   ++E 
Sbjct: 705  DQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEE 764

Query: 1261 LEKVK----HLENQIAKSPAIDSTRGDSSSLVAELQEKLQEE--KAKFLEQLEEQE---- 1310
            L  ++     L  ++    A  + +   +SLV EL++ + E+  K K +E+L E E    
Sbjct: 765  LNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKV 824

Query: 1311 KRKNEEMQNVRTSLIAEQQTNFNTVLTR-EKMRKENIINDLSDKLKSTMQQQERDKDLIE 1369
              K + +Q+++  + A ++   N  L + +++   + + +L + LK   +Q    K ++E
Sbjct: 825  ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLE 884

Query: 1370 SLSEDRARLLEEKKKLEEEVSKLRS 1394
               +D A   +  + L+EE   L++
Sbjct: 885  EKEKDLANTGKWLQDLQEENESLKA 909



 Score = 88.6 bits (218), Expect = 4e-17
 Identities = 161/765 (21%), Positives = 321/765 (41%), Gaps = 135/765 (17%)

Query: 807  DSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKH--- 863
            D+  S Q +++ L       QK      N  +   +++++I+E+ + +L+  +++ H   
Sbjct: 538  DTLVSKQQLEQRLMQLMESEQKRV----NKEESLQMQVQDILEQNE-ALKAQIQQFHSQI 592

Query: 864  --QKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKE 921
              Q     L  E    +    K+ ++ E+ +   +  L   EE L++  N   L+K E +
Sbjct: 593  AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652

Query: 922  AVICLQNE-----------------KDQKL--------------LEMENIMHSQN----C 946
             +  L NE                 KD K+              +E   I++ QN     
Sbjct: 653  KLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKS 712

Query: 947  EIKEL-----KQSREIVLEDLKKLHVENDEKLQLLRAELQS-LEQSHLKE-------LED 993
            E+++L     +Q  + V+E ++K   E DEKL+ +   L++ L Q   KE        E+
Sbjct: 713  EVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTEN 772

Query: 994  TLQVRHIQEFEKVMTDHRVS----LEELKK---ENQQIINQIQE-SHAEIIQ--EKEKQL 1043
            +   + +Q+ +    D +VS    +EELKK   E    I  ++E   AE+++   KEK +
Sbjct: 773  SSLTKEVQDLKAKQND-QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV 831

Query: 1044 QELKLKVSDLSDTRCKLEVELALKEAETDEIKIL--LEESRAQQKETLKSLLEQETENLR 1101
            Q+LK ++  L +    +++E A + + T +++ L  L + + +Q  T+K++LE++ ++L 
Sbjct: 832  QDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDL- 890

Query: 1102 TEISKLNQKIQDNNENYQVGLAELR------------------------------TLMTI 1131
                K  Q +Q+ NE+ +  + E+                                 M  
Sbjct: 891  ANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK 950

Query: 1132 EKDQCIS---ELISRHEEESNILKAELNKVTSL----------HNQAFEIEKNLKEQIIE 1178
            E++  +S   +L+   ++E+ + K+++ ++             H +  ++    +++I  
Sbjct: 951  ERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISG 1010

Query: 1179 LQSKLDSELSALERQKDEKITQQEEKYEAI--IQNLEKDRQKLVSSQEQDREQLIQKLNC 1236
            L ++LDS   A+E Q+ +    +E+ +EA+  + + EK  Q  V+   ++R+Q ++ +  
Sbjct: 1011 LWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVEL 1070

Query: 1237 EKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQ 1296
            E  E ++    +  +   +   E L    H   + AK   +  T G     V E + K  
Sbjct: 1071 EAKEVLKKLFPKVSVPSNLSYGEWL----HGFEKKAKE-CMAGTSGSEEVKVLEHKLKEA 1125

Query: 1297 EEKAKFLEQLEEQEKRKNEEMQNVRTSL--IAEQQTNFNTVLTREKMRKENIINDLSDKL 1354
            +E    L+   E+ K    E + +   L    EQ+ N   V   E       I  +    
Sbjct: 1126 DEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDE---SHKTIKQMQSSF 1182

Query: 1355 KSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACA 1414
             S+ Q+ ER    + S ++D   L  E++ LE E+ K   +    S YV    EL     
Sbjct: 1183 TSSEQELER----LRSENKDIENLRREREHLEMELEK---AEMERSTYVTEVRELKDLLT 1235

Query: 1415 PELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRI 1459
             EL  + D S  E   +    + ++  +      +     E+Q++
Sbjct: 1236 -ELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKV 1279



 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 110/563 (19%), Positives = 254/563 (45%), Gaps = 60/563 (10%)

Query: 786  EDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAV--E 843
            E  G   S+   LE   +   +   ++Q +K+++   +  +   Q + +  L  T+   E
Sbjct: 805  EKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQE 864

Query: 844  IRNII---EKVKCSLEITLKEKHQ------KELLSLKNEYEGKLDGLIKETEENENKIKK 894
            ++N++   E+   +++  L+EK +      K L  L+ E E  L   ++E  ++  K   
Sbjct: 865  LQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENES-LKAHVQEVAQHNLKEAS 923

Query: 895  LKGELVCLEEVLQNKDNEF----ALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKE 950
               +   LE VL+ K+NE     A++K E+E+ +  + +  Q + +   +  SQ  ++K+
Sbjct: 924  SASQFEELEIVLKEKENELKRLEAMLK-ERESDLSSKTQLLQDVQDENKLFKSQIEQLKQ 982

Query: 951  LKQSREIVL---EDLKKLHVENDEKLQLLRAELQSLEQS--HLKELEDTLQVRHIQEFEK 1005
                +       E+L K+  E ++++  L  EL SL+ +  H ++  + L+ ++ +  E 
Sbjct: 983  QNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEA 1042

Query: 1006 VMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELA 1065
            + +  ++  +++ K +++   Q++    E  +  +K   ++ +  S+LS        E  
Sbjct: 1043 LASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVP-SNLSYGEWLHGFEKK 1101

Query: 1066 LKE-----AETDEIKILLEESRAQQKETLKSLLEQETENLRTEIS-------KLNQKIQD 1113
             KE     + ++E+K+L  E + ++ + + +LL+ E E  ++ ++       KL + ++ 
Sbjct: 1102 AKECMAGTSGSEEVKVL--EHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQ 1159

Query: 1114 NNENYQVGLAEL-RTLMTIEK-----DQCISELISRHEEESNI------LKAELNKVTSL 1161
                ++V + E  +T+  ++      +Q +  L S +++  N+      L+ EL K    
Sbjct: 1160 EENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEME 1219

Query: 1162 HNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAI--IQNLEKDRQKL 1219
             +      + LK+ + ELQ KLD   S   RQ +E    + +  E +  ++  + +RQK+
Sbjct: 1220 RSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKV 1279

Query: 1220 VSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDS 1279
                 + ++ L         E IQ+ + +   +  V+E   +        +   S +++ 
Sbjct: 1280 AGDLHKAQQSL---------ELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQ 1330

Query: 1280 TRGDSSSLVAELQEKLQEEKAKF 1302
            T      L+  + ++L +EK  +
Sbjct: 1331 TVTQLQQLLQAVNQQLTKEKEHY 1353



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 68/301 (22%), Positives = 142/301 (47%), Gaps = 22/301 (7%)

Query: 840  TAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEE------NENKIK 893
            T+ E +  +E V+   +  LK+   K  +     Y   L G  K+ +E         ++K
Sbjct: 1057 TSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVK 1116

Query: 894  KLKGELVCLEEV---LQNKDNEFALVKHEKEAVIC-LQNEKDQKLLEMENIMHSQNCEIK 949
             L+ +L   +E+   LQ +  ++  V  E E ++  LQ   +Q+  + +  +   +  IK
Sbjct: 1117 VLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIK 1176

Query: 950  ELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLK-ELEDTLQVRHIQEFEKVMT 1008
            +++ S     ++L++L  EN + ++ LR E + LE    K E+E +  V  ++E + ++T
Sbjct: 1177 QMQSSFTSSEQELERLRSENKD-IENLRREREHLEMELEKAEMERSTYVTEVRELKDLLT 1235

Query: 1009 DHRVSLE----ELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLE-VE 1063
            + +  L+    E  ++N+++ N ++    E + +   +  E +    DL   +  LE ++
Sbjct: 1236 ELQKKLDDSYSEAVRQNEEL-NLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQ 1294

Query: 1064 LALKEAETDEIKI----LLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQ 1119
              + +A  D   I    +  E+ + +KET+   L Q    L+  +  +NQ++    E+YQ
Sbjct: 1295 SKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1354

Query: 1120 V 1120
            V
Sbjct: 1355 V 1355



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 103/517 (19%), Positives = 219/517 (42%), Gaps = 55/517 (10%)

Query: 1014 LEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDT--RCKLEVELALKEAET 1071
            L + K+E + I  +  +  AE  + K+K++Q   L  SD        KL   LA+++ + 
Sbjct: 38   LAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQV 97

Query: 1072 DEIKILLEES------RAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAEL 1125
              + + + E+      R ++++  K +LE++     ++ SK+  K     E   V     
Sbjct: 98   APVPLNVVETSSSVRERKKKEKKQKPVLEEQVIK-ESDASKIPGK---KVEPVPVTKQPT 153

Query: 1126 RTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDS 1185
                     +   +  S++  +    K E   V S   +A  + +  K++    + K  S
Sbjct: 154  PPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASS 213

Query: 1186 ELSALERQKDEKITQQEEKYEAIIQNLEK----DRQKLVSSQEQDREQLIQKLNCEK--- 1238
            +    E    ++       Y  ++ N +     D+++++   + D+ + IQK   +K   
Sbjct: 214  KKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKT 273

Query: 1239 ---DEAIQTALKEFKLEREVV---EKELLEKVKHLENQ--IAKSPAIDSTRGDSSSLVAE 1290
                E  +   K+F L  + +   E E L  V  L+ +  + +     S++G+ ++L+ +
Sbjct: 274  ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQ 333

Query: 1291 LQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREK-----MRKEN 1345
            LQ     EK K L  ++E      +  + +   ++ E++ + N V+TR K     + KE+
Sbjct: 334  LQ-----EKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERS-NVVITRMKDRIGTLEKEH 387

Query: 1346 II--NDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYV 1403
             +  N +    + T Q Q + + + E +  + A L +E   L + VS   +++ + S   
Sbjct: 388  NVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVS--NTTNQLESKQS 445

Query: 1404 ATAPEL---YGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIM 1460
            A   +L   Y     EL  ++ +   E   +   + A   + + VQ     L E ++R  
Sbjct: 446  AELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQA--ATQLKVQ-----LQEAERRWE 498

Query: 1461 LLERTLQLKEEENKRLNQRLMSQSM---SSVSSRHSE 1494
             ++  ++ +  E++   Q L S+ +   + V S HS+
Sbjct: 499  EVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSK 535


>gi|118498368 kinectin 1 isoform c [Homo sapiens]
          Length = 1300

 Score =  101 bits (252), Expect = 5e-21
 Identities = 142/625 (22%), Positives = 285/625 (45%), Gaps = 93/625 (14%)

Query: 849  EKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVC------- 901
            ++  C +++ LKEK      +LK   +G+L  LI + +E +  +  +K +          
Sbjct: 299  DEALCVVDL-LKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQ 357

Query: 902  -LEEVLQNKDNEFALVKHEKEAVICLQNEKD--------------QKLLEMENIMHSQNC 946
              +E++  K+    ++   K+ +  L+ E +              Q  ++ + +      
Sbjct: 358  LTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEA 417

Query: 947  EIKELKQS----REIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQE 1002
            EI  LKQ     R+ V     +L  +   +L  LR +   L  + L E    LQ   +Q+
Sbjct: 418  EIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARL-VNELTEKTGKLQQEEVQK 476

Query: 1003 --FEKVMTDHRVSLEELKKENQQIINQIQESHAE----------IIQEKEKQLQELKLKV 1050
               E+  T  +V L+E ++  +++ + I++  AE              KE ++Q L  K+
Sbjct: 477  KNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKL 536

Query: 1051 SDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQK 1110
            +D   ++ +LE  L ++  E+++ ++  EES   Q   ++ +LEQ  E L+ +I + + +
Sbjct: 537  TDTLVSKQQLEQRL-MQLMESEQKRVNKEESLQMQ---VQDILEQ-NEALKAQIQQFHSQ 591

Query: 1111 IQDNNENYQVGLAELRTLMTIEKDQCISE-----------LISRHEEESNI------LKA 1153
            I    +     LAE    +  EKD+ I +           L S+ EE  +I      LKA
Sbjct: 592  IA--AQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKA 649

Query: 1154 ELNKVTSLHNQ----AFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAI- 1208
            E+ K+ +L N+    A E+EK  +   ++     D ++  LE Q   +I+ + E+++ + 
Sbjct: 650  EVQKLQALANEQAAAAHELEKMQQSVYVK-----DDKIRLLEEQLQHEISNKMEEFKILN 704

Query: 1209 -----IQNLEKDRQKLVSSQ-EQDREQLIQKLNCEKDEAIQTA--LKEFKLEREVVEKEL 1260
                 +++  +  Q LVS Q  +D  + ++K   EKDE ++T   L E  L +   ++E 
Sbjct: 705  DQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEE 764

Query: 1261 LEKVK----HLENQIAKSPAIDSTRGDSSSLVAELQEKLQEE--KAKFLEQLEEQE---- 1310
            L  ++     L  ++    A  + +   +SLV EL++ + E+  K K +E+L E E    
Sbjct: 765  LNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKV 824

Query: 1311 KRKNEEMQNVRTSLIAEQQTNFNTVLTR-EKMRKENIINDLSDKLKSTMQQQERDKDLIE 1369
              K + +Q+++  + A ++   N  L + +++   + + +L + LK   +Q    K ++E
Sbjct: 825  ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLE 884

Query: 1370 SLSEDRARLLEEKKKLEEEVSKLRS 1394
               +D A   +  + L+EE   L++
Sbjct: 885  EKEKDLANTGKWLQDLQEENESLKA 909



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 164/689 (23%), Positives = 300/689 (43%), Gaps = 111/689 (16%)

Query: 807  DSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKH--- 863
            D+  S Q +++ L       QK      N  +   +++++I+E+ + +L+  +++ H   
Sbjct: 538  DTLVSKQQLEQRLMQLMESEQKRV----NKEESLQMQVQDILEQNE-ALKAQIQQFHSQI 592

Query: 864  --QKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKE 921
              Q     L  E    +    K+ ++ E+ +   +  L   EE L++  N   L+K E +
Sbjct: 593  AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652

Query: 922  AVICLQNE-----------------KDQKL--------------LEMENIMHSQN----C 946
             +  L NE                 KD K+              +E   I++ QN     
Sbjct: 653  KLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKS 712

Query: 947  EIKEL-----KQSREIVLEDLKKLHVENDEKLQLLRAELQS-LEQSHLKE-------LED 993
            E+++L     +Q  + V+E ++K   E DEKL+ +   L++ L Q   KE        E+
Sbjct: 713  EVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTEN 772

Query: 994  TLQVRHIQEFEKVMTDHRVS----LEELKK---ENQQIINQIQE-SHAEIIQ--EKEKQL 1043
            +   + +Q+ +    D +VS    +EELKK   E    I  ++E   AE+++   KEK +
Sbjct: 773  SSLTKEVQDLKAKQND-QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV 831

Query: 1044 QELKLKVSDLSDTRCKLEVELALKEAETDEIKIL--LEESRAQQKETLKSLLEQETENLR 1101
            Q+LK ++  L +    +++E A + + T +++ L  L + + +Q  T+K++LE++ ++L 
Sbjct: 832  QDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDL- 890

Query: 1102 TEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSL 1161
                K  Q +Q+ NE+ +  + E+      E         S+ EE   +LK + N++  L
Sbjct: 891  ANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA-----SQFEELEIVLKEKENELKRL 945

Query: 1162 HNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVS 1221
                 E E +L  +   LQ   D   + L + + E++ QQ  +  +     E +  K++S
Sbjct: 946  EAMLKERESDLSSKTQLLQDVQDE--NKLFKSQIEQLKQQNYQQASSFPPHE-ELLKVIS 1002

Query: 1222 SQEQDREQLIQKLNCEKDEAIQTALK--EFKLEREVVEKELLEKVKHLENQIA------- 1272
             +E++   L  +L+  KD       K  E + + E VE E  E +K L  +++       
Sbjct: 1003 EREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSY 1062

Query: 1273 -------KSPAIDSTRGDS-SSLVAELQEKLQE-EKAKFLEQLE-EQEKRKNEEMQNVRT 1322
                   +  A +   G S S  V  L+ KL+E ++   L QLE E+ K    E + +  
Sbjct: 1063 GEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQ 1122

Query: 1323 SL--IAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLE 1380
             L    EQ+ N   V   E       I  +     S+ Q+ ER    + S ++D   L  
Sbjct: 1123 KLQRSVEQEENKWKVKVDE---SHKTIKQMQSSFTSSEQELER----LRSENKDIENLRR 1175

Query: 1381 EKKKLEEEVSKLRSSSFVPSPYVATAPEL 1409
            E++ LE E+ K   +    S YV    EL
Sbjct: 1176 EREHLEMELEK---AEMERSTYVTEVREL 1201



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 130/607 (21%), Positives = 255/607 (42%), Gaps = 116/607 (19%)

Query: 832  DFSNSLKCTAVEIRNIIEK-----VKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKET- 885
            D + +LK    +++ ++ +     V   +E  ++EK +K    LK   E    GLI+   
Sbjct: 705  DQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK----LKTVEELLETGLIQVAT 760

Query: 886  -EENENKIKKLKGELVCLEEVLQNKDNE---FALVKHEKEAVICLQNEKDQKLLEMENIM 941
             EE  N I+     L    + L+ K N+   FA +  E + VI   +EKD K+  +E ++
Sbjct: 761  KEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVI---HEKDGKIKSVEELL 817

Query: 942  HSQNCEI-------KELKQSREIVLEDLKKLHVENDEKLQLLRA--ELQSLEQSHLKELE 992
             ++  ++       ++LKQ  + + E++  + +E  ++L +     ELQ+L +   +++ 
Sbjct: 818  EAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMN 877

Query: 993  DTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEK--QLQELKLKV 1050
                V  ++E EK + +    L++L++EN+ +   +QE     ++E     Q +EL++ +
Sbjct: 878  TMKAV--LEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVL 935

Query: 1051 SDLSDTRCKLEVELALKEAETDEIKILLEESRAQQK------------------------ 1086
             +  +   +LE  L  +E++      LL++ + + K                        
Sbjct: 936  KEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHE 995

Query: 1087 ETLKSLLEQETE--NLRTEISKL-----NQKIQDNNENYQVGLAELRTLMTIEK------ 1133
            E LK + E+E E   L  E+  L     +Q+ ++N    QV   EL     ++K      
Sbjct: 996  ELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVS 1055

Query: 1134 ------------------DQCISELISRHEEESNILKAELNKVTSLHNQA-FEIEKNLKE 1174
                               +C++   +   EE  +L+ +L +   +H     E EK  K 
Sbjct: 1056 VPSNLSYGEWLHGFEKKAKECMAG--TSGSEEVKVLEHKLKEADEMHTLLQLECEK-YKS 1112

Query: 1175 QIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQL---- 1230
             + E +  L     ++E+++++   + +E ++ I     K  Q   +S EQ+ E+L    
Sbjct: 1113 VLAETEGILQKLQRSVEQEENKWKVKVDESHKTI-----KQMQSSFTSSEQELERLRSEN 1167

Query: 1231 --IQKLNCEKDEAIQTALKEFKLER-----EVVE-----KELLEKVKHLENQIAK----- 1273
              I+ L  E+ E ++  L++ ++ER     EV E      E L K++  +N+  K     
Sbjct: 1168 KDIENLRRER-EHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDL 1226

Query: 1274 SPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFN 1333
              A  S     S +V    +    E +    + E  EK       N   + + +     N
Sbjct: 1227 HKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVN 1286

Query: 1334 TVLTREK 1340
              LT+EK
Sbjct: 1287 QQLTKEK 1293



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 98/471 (20%), Positives = 201/471 (42%), Gaps = 77/471 (16%)

Query: 1087 ETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQ-CISELISRHE 1145
            + ++ + +  T+ L+TE  K N +++     ++  L  L+T+M  E +  C+ +L+   +
Sbjct: 258  DQVEGIQKSGTKKLKTETDKENAEVK-----FKDFLLSLKTMMFSEDEALCVVDLL---K 309

Query: 1146 EESNILKAELNK-----VTSLHNQAFEIEKNL---KEQIIELQSK---LDSELSALERQK 1194
            E+S +++  L K     +T+L +Q  E +K L   KE     + +   L  E+   + + 
Sbjct: 310  EKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERS 369

Query: 1195 DEKITQQEEKYEAIIQNLEKDR---QKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKL 1251
            +  IT+ +++    I  LEK+    Q  +    Q+ +Q+  K   +  E ++  +   K 
Sbjct: 370  NVVITRMKDR----IGTLEKEHNVFQNKIHVSYQETQQMQMKFQ-QVREQMEAEIAHLKQ 424

Query: 1252 EREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEK---LQEEKAK------- 1301
            E  ++   +      LE++  +S  ++  R D + LV EL EK   LQ+E+ +       
Sbjct: 425  ENGILRDAVSNTTNQLESK--QSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQA 482

Query: 1302 ---FLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTM 1358
                  QL+E E+R  E    +R      +    +  L  + + KEN +  L  KL  T+
Sbjct: 483  ATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQD--LQSKFVAKENEVQSLHSKLTDTL 540

Query: 1359 -QQQERDKDLIESLSEDRAR-------------LLEEKKKLEEEVSKLRSSSFVPSPYVA 1404
              +Q+ ++ L++ +  ++ R             +LE+ + L+ ++ +  S     +    
Sbjct: 541  VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600

Query: 1405 TAPELYGACAPELPGESDRSAVETADEGRVD----SAMETSMMSVQENIHMLSEEKQRIM 1460
             A EL+   A     E D+   +T D    +    ++ E  +  +Q    +L  E Q++ 
Sbjct: 601  LAEELHKVIA-----EKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQ 655

Query: 1461 LLERTLQLKEEENKRLNQ---------RLMSQSMSSVSSRHSEKIAIRDFQ 1502
             L         E +++ Q         RL+ + +    S   E+  I + Q
Sbjct: 656  ALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ 706



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 103/517 (19%), Positives = 219/517 (42%), Gaps = 55/517 (10%)

Query: 1014 LEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDT--RCKLEVELALKEAET 1071
            L + K+E + I  +  +  AE  + K+K++Q   L  SD        KL   LA+++ + 
Sbjct: 38   LAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQV 97

Query: 1072 DEIKILLEES------RAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAEL 1125
              + + + E+      R ++++  K +LE++     ++ SK+  K     E   V     
Sbjct: 98   APVPLNVVETSSSVRERKKKEKKQKPVLEEQVIK-ESDASKIPGK---KVEPVPVTKQPT 153

Query: 1126 RTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDS 1185
                     +   +  S++  +    K E   V S   +A  + +  K++    + K  S
Sbjct: 154  PPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASS 213

Query: 1186 ELSALERQKDEKITQQEEKYEAIIQNLEK----DRQKLVSSQEQDREQLIQKLNCEK--- 1238
            +    E    ++       Y  ++ N +     D+++++   + D+ + IQK   +K   
Sbjct: 214  KKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKT 273

Query: 1239 ---DEAIQTALKEFKLEREVV---EKELLEKVKHLENQ--IAKSPAIDSTRGDSSSLVAE 1290
                E  +   K+F L  + +   E E L  V  L+ +  + +     S++G+ ++L+ +
Sbjct: 274  ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQ 333

Query: 1291 LQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREK-----MRKEN 1345
            LQ     EK K L  ++E      +  + +   ++ E++ + N V+TR K     + KE+
Sbjct: 334  LQ-----EKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERS-NVVITRMKDRIGTLEKEH 387

Query: 1346 II--NDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYV 1403
             +  N +    + T Q Q + + + E +  + A L +E   L + VS   +++ + S   
Sbjct: 388  NVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVS--NTTNQLESKQS 445

Query: 1404 ATAPEL---YGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIM 1460
            A   +L   Y     EL  ++ +   E   +   + A   + + VQ     L E ++R  
Sbjct: 446  AELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQA--ATQLKVQ-----LQEAERRWE 498

Query: 1461 LLERTLQLKEEENKRLNQRLMSQSM---SSVSSRHSE 1494
             ++  ++ +  E++   Q L S+ +   + V S HS+
Sbjct: 499  EVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSK 535



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 62/301 (20%), Positives = 129/301 (42%), Gaps = 47/301 (15%)

Query: 862  KHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKH--- 918
            + +KE+  L NE +   D +  + ++N  + ++++   +  +EVL+    + ++  +   
Sbjct: 1003 EREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSY 1062

Query: 919  -------EKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDE 971
                   EK+A  C+      +  E++ + H    E  E+    ++  E  K +  E + 
Sbjct: 1063 GEWLHGFEKKAKECMAGTSGSE--EVKVLEHKLK-EADEMHTLLQLECEKYKSVLAETEG 1119

Query: 972  KLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQE- 1030
             LQ L+  ++  E     +++++ +   I++ +   T     LE L+ EN+ I N  +E 
Sbjct: 1120 ILQKLQRSVEQEENKWKVKVDESHKT--IKQMQSSFTSSEQELERLRSENKDIENLRRER 1177

Query: 1031 SHAEIIQEKEKQ-----LQELKLKVSDLSDTRCKLEVEL------------ALKEAETDE 1073
             H E+  EK +      + E++   + L++T  KL  E             A +  E  +
Sbjct: 1178 EHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQ 1237

Query: 1074 IKILLE--------------ESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQ 1119
             KI+                E+ + +KET+   L Q    L+  +  +NQ++    E+YQ
Sbjct: 1238 SKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1297

Query: 1120 V 1120
            V
Sbjct: 1298 V 1298


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.129    0.356 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,938,716
Number of Sequences: 37866
Number of extensions: 2576336
Number of successful extensions: 27615
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 295
Number of HSP's successfully gapped in prelim test: 1471
Number of HSP's that attempted gapping in prelim test: 12092
Number of HSP's gapped (non-prelim): 7488
length of query: 1591
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1475
effective length of database: 13,855,062
effective search space: 20436216450
effective search space used: 20436216450
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.