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Search of human proteins with 55770854
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
[Homo sapiens]
(1233 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [... 2531 0.0
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ... 1106 0.0
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ... 1019 0.0
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ... 1019 0.0
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr... 1019 0.0
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ... 1001 0.0
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate... 278 3e-74
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat... 277 5e-74
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 273 1e-72
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 270 5e-72
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 270 5e-72
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H... 196 1e-49
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p... 194 3e-49
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H... 194 4e-49
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p... 194 6e-49
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H... 182 2e-45
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr... 182 2e-45
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre... 182 2e-45
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens] 176 1e-43
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p... 174 4e-43
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p... 172 1e-42
gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p... 172 2e-42
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens] 172 2e-42
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ... 172 2e-42
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ... 171 4e-42
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ... 171 4e-42
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ... 171 5e-42
gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens] 159 2e-38
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H... 149 2e-35
gi|157168329 formin 1 [Homo sapiens] 59 4e-08
>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [Homo
sapiens]
Length = 1233
Score = 2531 bits (6560), Expect = 0.0
Identities = 1233/1233 (100%), Positives = 1233/1233 (100%)
Query: 1 MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPL 60
MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPL
Sbjct: 1 MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPL 60
Query: 61 EIQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPIL 120
EIQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPIL
Sbjct: 61 EIQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPIL 120
Query: 121 SISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLE 180
SISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLE
Sbjct: 121 SISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLE 180
Query: 181 GVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEA 240
GVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEA
Sbjct: 181 GVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEA 240
Query: 241 AQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGA 300
AQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGA
Sbjct: 241 AQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGA 300
Query: 301 HSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVV 360
HSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVV
Sbjct: 301 HSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVV 360
Query: 361 IALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD 420
IALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD
Sbjct: 361 IALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD 420
Query: 421 PGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTN 480
PGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTN
Sbjct: 421 PGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTN 480
Query: 481 GKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNG 540
GKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNG
Sbjct: 481 GKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNG 540
Query: 541 TVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIG 600
TVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIG
Sbjct: 541 TVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIG 600
Query: 601 KSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTV 660
KSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTV
Sbjct: 601 KSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTV 660
Query: 661 SGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKM 720
SGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKM
Sbjct: 661 SGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKM 720
Query: 721 GKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQF 780
GKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQF
Sbjct: 721 GKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQF 780
Query: 781 LGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVY 840
LGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVY
Sbjct: 781 LGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVY 840
Query: 841 WKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAA 900
WKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAA
Sbjct: 841 WKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAA 900
Query: 901 RDMVTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGW 960
RDMVTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGW
Sbjct: 901 RDMVTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGW 960
Query: 961 GPPDGGRAALVRRAPQPPGRPPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASER 1020
GPPDGGRAALVRRAPQPPGRPPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASER
Sbjct: 961 GPPDGGRAALVRRAPQPPGRPPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASER 1020
Query: 1021 PLSPARCHYSSFPRADRSGRPFLPLFPELEDLPLLGPEQLARREALLHAAWARGSRPRHA 1080
PLSPARCHYSSFPRADRSGRPFLPLFPELEDLPLLGPEQLARREALLHAAWARGSRPRHA
Sbjct: 1021 PLSPARCHYSSFPRADRSGRPFLPLFPELEDLPLLGPEQLARREALLHAAWARGSRPRHA 1080
Query: 1081 SLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRLAQAQSMCLPIYREACQEGEQAGA 1140
SLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRLAQAQSMCLPIYREACQEGEQAGA
Sbjct: 1081 SLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRLAQAQSMCLPIYREACQEGEQAGA 1140
Query: 1141 PAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGHRGRTLGLGTGYRD 1200
PAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGHRGRTLGLGTGYRD
Sbjct: 1141 PAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGHRGRTLGLGTGYRD 1200
Query: 1201 SGGLDEISRVARGTQGFPGPCTWRRISSLESEV 1233
SGGLDEISRVARGTQGFPGPCTWRRISSLESEV
Sbjct: 1201 SGGLDEISRVARGTQGFPGPCTWRRISSLESEV 1233
>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor [Homo
sapiens]
Length = 1336
Score = 1106 bits (2861), Expect = 0.0
Identities = 597/1037 (57%), Positives = 714/1037 (68%), Gaps = 67/1037 (6%)
Query: 22 GPGQGEQG---MTVAVVFSSSGPPQAQFRARLTPQ---SFLDLPLEIQPLTVGVNTTNPS 75
GPG G G + VA+VFS GP A ARL P + L+++P+ + +N ++P
Sbjct: 40 GPGGGLGGARPLNVALVFS--GPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPR 97
Query: 76 SLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGSAVVLTPKEP 135
SL+ Q+C LL VHG+VFED+ AVA ILDF+S+QT +PI+++ GG+A+VLTPKE
Sbjct: 98 SLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEK 157
Query: 136 GSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASHVSWRL 195
GS FLQLG S EQQLQV+F+VLEEYDW++F +T+ PGH FL + + D S V W
Sbjct: 158 GSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEH 217
Query: 196 LDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHVWLV- 254
+TL+ PG A LR + A + + +C+REEAE +F A +AGL G G+VW +
Sbjct: 218 RGALTLD--PGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMV 275
Query: 255 -PNLALGSTDAPP---------ATFPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYW 304
P LA G P A P GL +V + WR L ++V GVA++A GA +
Sbjct: 276 GPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALL 335
Query: 305 RQHGTLPAPAGDCRV----HPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVV 360
R +G LP DCR H G E+ +R+ +N+TW+ RD+SF+ G+LV P++VV
Sbjct: 336 RDYGFLPELGHDCRAQNRTHRG------ESLHRYFMNITWDNRDYSFNEDGFLVNPSLVV 389
Query: 361 IALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD 420
I+L R R WE+VG WE L +KYP+W RY LQPV D++HLTVATLEERPFVIVE D
Sbjct: 390 ISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPAD 449
Query: 421 PGTGGCVPNTVPCRRQSNHTFSSGDVAPYT-KLCCKGFCIDILKKLARVVKFSYDLYLVT 479
P +G C+ ++VPCR Q N T S AP K CCKGFCIDILK+LA + FSYDLYLVT
Sbjct: 450 PISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVT 509
Query: 480 NGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSN 539
NGKHGK++ GVWNGMIGEV+Y+RADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSN
Sbjct: 510 NGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSN 569
Query: 540 GTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTI 599
GTVSPSAFLEPYSPAVWVMMFVMCLTVVA+TVF+FEY SPV YN++L GK+ GG FTI
Sbjct: 570 GTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTI 629
Query: 600 GKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDT 659
GKS+WLLWALVFNNSVP+ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQE+Y+DT
Sbjct: 630 GKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDT 689
Query: 660 VSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLK 719
VSGLSD+KFQRPQ+QYPP +FGTVPNGSTE+NIRSNY DMH++MV++NQ VE+ALT LK
Sbjct: 690 VSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLK 749
Query: 720 MGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQ 779
GKLDAFIYDAAVLNYMA KDEGCKLVTIGSGKVFATTGYGIA+ K S WKR IDLALLQ
Sbjct: 750 AGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQ 809
Query: 780 FLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLV 839
FLGD E + LE +WLSGIC N+K EVMSSKLDIDNMAGVFYMLLVAMGL+LLVFAWEHLV
Sbjct: 810 FLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLV 869
Query: 840 YWKLRHSVPNSSQLDFLLAFSRGIYSCFSG------------VQSLASP----PRQA-SP 882
YW+LRH + + ++DFLLAFSRG+YSC S Q L SP PR A P
Sbjct: 870 YWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAPRPAPGP 929
Query: 883 DLTASSAQASVLKMLQA-ARDMVTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRSG 941
+ASV + + AG++ R IE G G P +G
Sbjct: 930 APFVPRERASVDRWRRTKGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEARAAPRGAAG 989
Query: 942 PSPCLPTPDPPPEPSPTGWG---------PPDGGRAALVRRAPQPPGRPPTP----GPPL 988
P PP +P P+ + PP G P PP P GPPL
Sbjct: 990 RPLSPPAAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGF----PSPPAPPAAAATAVGPPL 1045
Query: 989 SDVSRVSRRPAWEARWP 1005
++ P ARWP
Sbjct: 1046 CRLAFEDESPPAPARWP 1062
Score = 34.3 bits (77), Expect = 0.75
Identities = 71/246 (28%), Positives = 90/246 (36%), Gaps = 37/246 (15%)
Query: 924 GGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGWGPPDGGRAALVRRAPQPPGRPPT 983
GGG A PP PC R+ P PC P D P PS + GG A+L P P
Sbjct: 1086 GGGAPAAPP-PC---RAAPPPC-PYLDLEPSPSDSEDSESLGG-ASLGGLEPWWFADFPY 1139
Query: 984 P-----GPPLSDVSRVSRRPAWEA-RW---PVRTG----HCGRHLSASERPLSPARCHYS 1030
P GPP V + W A W P R+G HC RH ++ E L P R +
Sbjct: 1140 PYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHC-RHCASLEL-LPPPR--HL 1195
Query: 1031 SFPRADRSGRPFLPLFPELEDLPLLGPEQLARREALLHAAWARGSRPRHA-SLPSSVAEA 1089
S G + P P P L RR A + RPR + P++ A
Sbjct: 1196 SCSHDGLDGGWWAPPPPPWAAGP------LPRRRARCGCPRSHPHRPRASHRTPAAAAPH 1249
Query: 1090 FARPSSLPAGC----TGPACARPDGHSACRRLAQAQSMCLPI-YREACQEGEQAG--APA 1142
R G P + S+C R A A+ + P + C G P
Sbjct: 1250 HHRHRRAAGGWDLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPT 1309
Query: 1143 WQHRQH 1148
HR+H
Sbjct: 1310 ASHRRH 1315
>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
precursor [Homo sapiens]
Length = 1281
Score = 1019 bits (2635), Expect = 0.0
Identities = 512/915 (55%), Positives = 654/915 (71%), Gaps = 23/915 (2%)
Query: 7 PALLLTSLFGAWAGLGPG----QGEQGMTVAVVFSSSGP-PQAQFRARLTPQSFLDLPLE 61
PALL+ W G P +G + +AV+ S + + R P+ LPL+
Sbjct: 13 PALLV------WRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLD 66
Query: 62 IQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILS 121
+ + + +N T+P SL+T +C L+ A +HG+VF D+ D EAVAQ+LDFISS T VPIL
Sbjct: 67 VNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILG 126
Query: 122 ISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEG 181
I GG+++++ K+P S F Q G S++QQ V+ K++++YDW F+++T++ PG+ F+
Sbjct: 127 IHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISF 186
Query: 182 VRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAA 241
V+ D S V W + +V+TL+ A+TQ L+++ + V + YCS++EA ++ +EA
Sbjct: 187 VKTTVDNSFVGWDMQNVITLDTS--FEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEAR 244
Query: 242 QAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGAH 301
GL G W+VP+L G+T+ P FP GLISV + W SL +VRDG+ IL A
Sbjct: 245 SLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAAS 304
Query: 302 SYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVI 361
S + +P C + ++NVTW+G+D SF+ GY V P +VVI
Sbjct: 305 SMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPRLVVI 364
Query: 362 ALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPDP 421
LN+ R WE VG+WE+ L +++ VWPRY + D HL++ TLEE PFVIVE DP
Sbjct: 365 VLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDP 424
Query: 422 GTGGCVPNTVPCRR--QSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVT 479
T CV NTVPCR+ + N++ + G K CCKGFCIDILKKL+R VKF+YDLYLVT
Sbjct: 425 LTETCVRNTVPCRKFVKINNSTNEG---MNVKKCCKGFCIDILKKLSRTVKFTYDLYLVT 481
Query: 480 NGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSN 539
NGKHGK+V VWNGMIGEV Y+RA MA+GSLTINEERSE+VDFSVPFVETGISVMV+RSN
Sbjct: 482 NGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSN 541
Query: 540 GTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTI 599
GTVSPSAFLEP+S +VWVMMFVM L V AI VF+FEYFSPV YN+NL +GK GP+FTI
Sbjct: 542 GTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTI 601
Query: 600 GKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDT 659
GK++WLLW LVFNNSVP++NP+GTTSKIMV VWAFFAVIFLASYTANLAAFMIQE+++D
Sbjct: 602 GKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQ 661
Query: 660 VSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLK 719
V+GLSDKKFQRP D PPFRFGTVPNGSTERNIR+NY MH +M KFNQ+ VEDAL SLK
Sbjct: 662 VTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLK 721
Query: 720 MGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQ 779
GKLDAFIYDAAVLNY AG+DEGCKLVTIGSG +FATTGYGIA+QK S WKR IDLALLQ
Sbjct: 722 TGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQ 781
Query: 780 FLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLV 839
F+GDGE ++LET+WL+GIC NEKNEVMSS+LDIDNMAGVFYML AM L+L+ F WEHL
Sbjct: 782 FVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
Query: 840 YWKLRHSVPN--SSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKML 897
YWKLR S + L + SRGIYSC GV ++ SPD + +Q+++LK+L
Sbjct: 842 YWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVH---IEEKKKSPDFNLTGSQSNMLKLL 898
Query: 898 QAARDMVTTAGVSSS 912
++A+++ + + ++SS
Sbjct: 899 RSAKNISSMSNMNSS 913
>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 1019 bits (2635), Expect = 0.0
Identities = 512/915 (55%), Positives = 654/915 (71%), Gaps = 23/915 (2%)
Query: 7 PALLLTSLFGAWAGLGPG----QGEQGMTVAVVFSSSGP-PQAQFRARLTPQSFLDLPLE 61
PALL+ W G P +G + +AV+ S + + R P+ LPL+
Sbjct: 13 PALLV------WRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLD 66
Query: 62 IQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILS 121
+ + + +N T+P SL+T +C L+ A +HG+VF D+ D EAVAQ+LDFISS T VPIL
Sbjct: 67 VNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILG 126
Query: 122 ISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEG 181
I GG+++++ K+P S F Q G S++QQ V+ K++++YDW F+++T++ PG+ F+
Sbjct: 127 IHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISF 186
Query: 182 VRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAA 241
V+ D S V W + +V+TL+ A+TQ L+++ + V + YCS++EA ++ +EA
Sbjct: 187 VKTTVDNSFVGWDMQNVITLDTS--FEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEAR 244
Query: 242 QAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGAH 301
GL G W+VP+L G+T+ P FP GLISV + W SL +VRDG+ IL A
Sbjct: 245 SLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAAS 304
Query: 302 SYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVI 361
S + +P C + ++NVTW+G+D SF+ GY V P +VVI
Sbjct: 305 SMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPRLVVI 364
Query: 362 ALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPDP 421
LN+ R WE VG+WE+ L +++ VWPRY + D HL++ TLEE PFVIVE DP
Sbjct: 365 VLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDP 424
Query: 422 GTGGCVPNTVPCRR--QSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVT 479
T CV NTVPCR+ + N++ + G K CCKGFCIDILKKL+R VKF+YDLYLVT
Sbjct: 425 LTETCVRNTVPCRKFVKINNSTNEG---MNVKKCCKGFCIDILKKLSRTVKFTYDLYLVT 481
Query: 480 NGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSN 539
NGKHGK+V VWNGMIGEV Y+RA MA+GSLTINEERSE+VDFSVPFVETGISVMV+RSN
Sbjct: 482 NGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSN 541
Query: 540 GTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTI 599
GTVSPSAFLEP+S +VWVMMFVM L V AI VF+FEYFSPV YN+NL +GK GP+FTI
Sbjct: 542 GTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTI 601
Query: 600 GKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDT 659
GK++WLLW LVFNNSVP++NP+GTTSKIMV VWAFFAVIFLASYTANLAAFMIQE+++D
Sbjct: 602 GKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQ 661
Query: 660 VSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLK 719
V+GLSDKKFQRP D PPFRFGTVPNGSTERNIR+NY MH +M KFNQ+ VEDAL SLK
Sbjct: 662 VTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLK 721
Query: 720 MGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQ 779
GKLDAFIYDAAVLNY AG+DEGCKLVTIGSG +FATTGYGIA+QK S WKR IDLALLQ
Sbjct: 722 TGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQ 781
Query: 780 FLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLV 839
F+GDGE ++LET+WL+GIC NEKNEVMSS+LDIDNMAGVFYML AM L+L+ F WEHL
Sbjct: 782 FVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
Query: 840 YWKLRHSVPN--SSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKML 897
YWKLR S + L + SRGIYSC GV ++ SPD + +Q+++LK+L
Sbjct: 842 YWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVH---IEEKKKSPDFNLTGSQSNMLKLL 898
Query: 898 QAARDMVTTAGVSSS 912
++A+++ + + ++SS
Sbjct: 899 RSAKNISSMSNMNSS 913
>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 1019 bits (2635), Expect = 0.0
Identities = 512/915 (55%), Positives = 654/915 (71%), Gaps = 23/915 (2%)
Query: 7 PALLLTSLFGAWAGLGPG----QGEQGMTVAVVFSSSGP-PQAQFRARLTPQSFLDLPLE 61
PALL+ W G P +G + +AV+ S + + R P+ LPL+
Sbjct: 13 PALLV------WRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLD 66
Query: 62 IQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILS 121
+ + + +N T+P SL+T +C L+ A +HG+VF D+ D EAVAQ+LDFISS T VPIL
Sbjct: 67 VNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILG 126
Query: 122 ISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEG 181
I GG+++++ K+P S F Q G S++QQ V+ K++++YDW F+++T++ PG+ F+
Sbjct: 127 IHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISF 186
Query: 182 VRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAA 241
V+ D S V W + +V+TL+ A+TQ L+++ + V + YCS++EA ++ +EA
Sbjct: 187 VKTTVDNSFVGWDMQNVITLDTS--FEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEAR 244
Query: 242 QAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGAH 301
GL G W+VP+L G+T+ P FP GLISV + W SL +VRDG+ IL A
Sbjct: 245 SLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAAS 304
Query: 302 SYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVI 361
S + +P C + ++NVTW+G+D SF+ GY V P +VVI
Sbjct: 305 SMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPRLVVI 364
Query: 362 ALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPDP 421
LN+ R WE VG+WE+ L +++ VWPRY + D HL++ TLEE PFVIVE DP
Sbjct: 365 VLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDP 424
Query: 422 GTGGCVPNTVPCRR--QSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVT 479
T CV NTVPCR+ + N++ + G K CCKGFCIDILKKL+R VKF+YDLYLVT
Sbjct: 425 LTETCVRNTVPCRKFVKINNSTNEG---MNVKKCCKGFCIDILKKLSRTVKFTYDLYLVT 481
Query: 480 NGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSN 539
NGKHGK+V VWNGMIGEV Y+RA MA+GSLTINEERSE+VDFSVPFVETGISVMV+RSN
Sbjct: 482 NGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSN 541
Query: 540 GTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTI 599
GTVSPSAFLEP+S +VWVMMFVM L V AI VF+FEYFSPV YN+NL +GK GP+FTI
Sbjct: 542 GTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTI 601
Query: 600 GKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDT 659
GK++WLLW LVFNNSVP++NP+GTTSKIMV VWAFFAVIFLASYTANLAAFMIQE+++D
Sbjct: 602 GKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQ 661
Query: 660 VSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLK 719
V+GLSDKKFQRP D PPFRFGTVPNGSTERNIR+NY MH +M KFNQ+ VEDAL SLK
Sbjct: 662 VTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLK 721
Query: 720 MGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQ 779
GKLDAFIYDAAVLNY AG+DEGCKLVTIGSG +FATTGYGIA+QK S WKR IDLALLQ
Sbjct: 722 TGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQ 781
Query: 780 FLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLV 839
F+GDGE ++LET+WL+GIC NEKNEVMSS+LDIDNMAGVFYML AM L+L+ F WEHL
Sbjct: 782 FVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
Query: 840 YWKLRHSVPN--SSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKML 897
YWKLR S + L + SRGIYSC GV ++ SPD + +Q+++LK+L
Sbjct: 842 YWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVH---IEEKKKSPDFNLTGSQSNMLKLL 898
Query: 898 QAARDMVTTAGVSSS 912
++A+++ + + ++SS
Sbjct: 899 RSAKNISSMSNMNSS 913
>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor
[Homo sapiens]
Length = 1484
Score = 1001 bits (2588), Expect = 0.0
Identities = 490/849 (57%), Positives = 620/849 (73%), Gaps = 5/849 (0%)
Query: 67 VGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGS 126
V +N T+P S++T+IC L+ + G+VF D+ D EA+AQILDFIS+QT PIL I GGS
Sbjct: 71 VAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGS 130
Query: 127 AVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVA 186
++++ K+ S F Q G S+EQQ V+ ++EEYDW F+++T+ PG+ F+ +R+
Sbjct: 131 SMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTI 190
Query: 187 DASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLV 246
+ S V W L +V+ L++ ++ Q L++L +P+ + YC++EEA +F A GL
Sbjct: 191 ENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLT 250
Query: 247 GPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYWRQ 306
G G+ W+VP+L G TD PA FP GLISV + W L +VRDG+AI+ A +
Sbjct: 251 GYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSE 310
Query: 307 HGTLPAPAGDC-RVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALNR 365
H +P P C H + + R+L+NVT+EGR+ SFS GY + P +V+I LN+
Sbjct: 311 HSFIPEPKSSCYNTHEKRIYQSN-MLNRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNK 369
Query: 366 HRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPDPGTGG 425
R WE VG+W+ L MKY VWPR + D HL++ TLEE PFVIVES DP +G
Sbjct: 370 ERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDD-HLSIVTLEEAPFVIVESVDPLSGT 428
Query: 426 CVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGK 485
C+ NTVPC+++ + + Y K CCKGFCIDILKK+++ VKF+YDLYLVTNGKHGK
Sbjct: 429 CMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGK 488
Query: 486 RVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS 545
++ G WNGMIGEV KRA MA+GSLTINEERSE+VDFSVPF+ETGISVMV+RSNGTVSPS
Sbjct: 489 KINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPS 548
Query: 546 AFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWL 605
AFLEP+S VWVMMFVM L V A+ VF+FEYFSPV YN+ L G++ GGP+FTIGK++WL
Sbjct: 549 AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWL 608
Query: 606 LWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSD 665
LW LVFNNSVP++NP+GTTSKIMV VWAFFAVIFLASYTANLAAFMIQE+Y+D VSGLSD
Sbjct: 609 LWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSD 668
Query: 666 KKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGKLDA 725
KKFQRP D PPFRFGTVPNGSTERNIR+NY +MH +M KFNQR V+DAL SLK GKLDA
Sbjct: 669 KKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKLDA 728
Query: 726 FIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGE 785
FIYDAAVLNYMAG+DEGCKLVTIGSGKVFA+TGYGIA+QKDS WKR +DLA+LQ GDGE
Sbjct: 729 FIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGE 788
Query: 786 TQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRH 845
++LE +WL+GIC NEKNEVMSS+LDIDNMAGVFYML AM L+L+ F EHL YW+ RH
Sbjct: 789 MEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFRH 848
Query: 846 SVPN--SSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAARDM 903
S + + + SRGIYSC GV SP T ++ +++L++L+ A++M
Sbjct: 849 CFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNM 908
Query: 904 VTTAGVSSS 912
+GV+ S
Sbjct: 909 ANLSGVNGS 917
>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
[Homo sapiens]
Length = 1043
Score = 278 bits (710), Expect = 3e-74
Identities = 272/979 (27%), Positives = 432/979 (44%), Gaps = 100/979 (10%)
Query: 47 RARLTPQSFLDLPLEIQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQ 106
RA L P+ +L LE+ + +P+SL +C L V ++ E +
Sbjct: 59 RAALAPRLPHNLSLEL--VVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELLQ- 115
Query: 107 ILDFISSQTHVPILSISGGSA-VVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWS-- 163
L F+++ T P+LS+ A L P L LE L VL VL+ + W
Sbjct: 116 -LHFLAAATETPVLSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDV 174
Query: 164 AFAVITSLHPGHALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQL--DA 221
A+ + PG + L RA V LD+ + G G RAR + + +A
Sbjct: 175 GLALCRTQDPGGLVALWTSRAGRPPQLV----LDLSRRDTGDAGLRARLAPMAAPVGGEA 230
Query: 222 PVFVAYCSREEAEVLFAEAAQAG----LVGPGHVWLVPNLALGSTDAPPATFPVGLISVV 277
PV A +L + A+A V PG WL+ L P A P GL+++
Sbjct: 231 PV-------PAAVLLGCDIARARRVLEAVPPGPHWLL-GTPLPPKALPTAGLPPGLLAL- 281
Query: 278 TESWRLSLRQKVRDGVAILA--LGAHSYWR-QHGTLPAPAGDCRVHP-GPVSPAREAFYR 333
E R L + D V ++A LG+ + + + LPAP + P GP SP R R
Sbjct: 282 GEVARPPLEAAIHDIVQLVARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGR-FLAR 340
Query: 334 HLLNVTWEGRDFSFSPGGYLVQPTMVVIALNRHRLWEM------------VGRWEHGVLY 381
L N +++GR G V + V ++W + VG W G L
Sbjct: 341 FLANTSFQGRT-----GPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLD 395
Query: 382 MKYPVWPRYSASLQPVVDSRH----LTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQS 437
++ P +++ P L V TL E PFV PD G C + +
Sbjct: 396 LE----PGGASARPPPPQGAQVWPKLRVVTLLEHPFVFARDPDED-GQCPAGQLCLDPGT 450
Query: 438 NHT---------FSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRVR 488
N + ++G + CC G+CID+L++LA F ++LYLV +GK+G
Sbjct: 451 NDSATLDALFAALANGSAPRALRKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALRD 510
Query: 489 GVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSP-SAF 547
G W G++G++ RA MA+ S +IN RS++VDF+ PF T + +MV R+ T SP AF
Sbjct: 511 GRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMV-RARDTASPIGAF 569
Query: 548 LEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLW 607
+ P + W+ +F L + A+ + ++E+ SP LT ++ F+ ++ L +
Sbjct: 570 MWPLHWSTWLGVFA-ALHLTALFLTVYEWRSP----YGLTPRGRNRSTVFSYSSALNLCY 624
Query: 608 ALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKK 667
A++F +V + P+ T ++++ +WA F ++ L+SYTANLAA M+ ++ + +SG+ D K
Sbjct: 625 AILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPK 684
Query: 668 FQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMG--KLDA 725
P FRFGTV S E I+ ++ DMH HM + + + + L KL+A
Sbjct: 685 LHHPAQ---GFRFGTVWESSAEAYIKKSFPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNA 741
Query: 726 FIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGE 785
FI D ++L+Y D CKL+T+ GK FA GYGI + ++S + + ++ G
Sbjct: 742 FIMDKSLLDYEVSIDADCKLLTV--GKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGF 799
Query: 786 TQKLETVWLSGI-CQNEKNEVMSS-KLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKL 843
L W + C V + ++ I + AG+F +L + +G ALL EH +
Sbjct: 800 IDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLA 859
Query: 844 RHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAARDM 903
+ S+L + L S+ I+ + PP + + + ++ Q +D
Sbjct: 860 LPRIRKGSRLQYWLHTSQKIHRALN-----TEPPEGSKEETAEAEPSGPEVEQQQQQQDQ 914
Query: 904 VTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRS-GPSPCLPTPDP--------PPE 954
T RA R ++ R P+ P + + P P PP
Sbjct: 915 PT---APEGWKRARRAVDKERRVRFLLEPAVVVAPEADAEAEAAPREGPVWLCSYGRPPA 971
Query: 955 PSPTGWGPPDGGRAALVRR 973
PTG P G L RR
Sbjct: 972 ARPTG-APQPGELQELERR 989
>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate
3A [Homo sapiens]
Length = 1115
Score = 277 bits (708), Expect = 5e-74
Identities = 229/839 (27%), Positives = 388/839 (46%), Gaps = 77/839 (9%)
Query: 71 TTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGSAVVL 130
+++P S L +C + V ++ E + LD +S H+P++SI
Sbjct: 174 SSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMME--LDLVSLVLHIPVISIVRHEF--- 228
Query: 131 TPKEPGSAFLQLGVSLEQQLQ----VLFKVLEEYDWSAFAVITSLHPGHAL-FLEGVRAV 185
P+E + L L +SLE L V +L +W F+++ + FL +
Sbjct: 229 -PRESQNP-LHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFL-----L 281
Query: 186 ADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDA-----PVFVAY-CSREEAEVLFAE 239
++ + L ++ + + L QL++ P V + C E +F
Sbjct: 282 LTQNNSKFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEI 341
Query: 240 AAQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLIS--VVTESWRLSLRQKVRDGVAILA 297
Q G++ P W++ + + + P+GLI+ T+S Q + VA
Sbjct: 342 TTQFGVMPPELRWVLGD-SQNVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAV 400
Query: 298 LGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPT 357
A + +P+ V ++ + R L N T+ G G V+ +
Sbjct: 401 ATATMIQPELALIPSTMNCMEVETTNLTSG-QYLSRFLANTTFRGLS-----GSIRVKGS 454
Query: 358 MVVIALNRHRLWEM------------VGRWEHGVLYMKYPVWP----RYSASLQPVVDSR 401
+V + N +W + +G W+ G + M Y +WP R+ Q
Sbjct: 455 TIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHP-SKL 513
Query: 402 HLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHT----------FSSGDVAPYT- 450
HL V TL E PFV D G C + +N + SS D P
Sbjct: 514 HLRVVTLIEHPFVFTREVDD-EGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKF 572
Query: 451 KLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSL 510
K CC G+CID+L+K+A + F +DLY+V +GK+G G W G++G++ A MA+ S
Sbjct: 573 KKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSF 632
Query: 511 TINEERSEIVDFSVPFVETGISVMVARSNGTVSP-SAFLEPYSPAVWVMMFVMCLTVVAI 569
+IN RS+++DF+ PF T + ++V R+ T +P AF+ P +W+ +FV L + A+
Sbjct: 633 SINTARSQVIDFTSPFFSTSLGILV-RTRDTAAPIGAFMWPLHWTMWLGIFV-ALHITAV 690
Query: 570 TVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMV 629
+ ++E+ SP LT ++ F+ ++ + +AL+F +V I+ P+ T + ++
Sbjct: 691 FLTLYEWKSPF----GLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLM 746
Query: 630 LVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTE 689
+WA F + L++YTANLAA M+ E+ + +SG+ D K P FRFGTV S E
Sbjct: 747 NLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQ---GFRFGTVRESSAE 803
Query: 690 RNIRSNYRDMHTHMVKFNQRSVEDALTSLKMG--KLDAFIYDAAVLNYMAGKDEGCKLVT 747
+R ++ +MH +M ++N + D + LK KLDAFI D A+L+Y D CKL+T
Sbjct: 804 DYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLT 863
Query: 748 IGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMS 807
+ GK FA GYGI + +S I + Q+ G L W + +++ ++
Sbjct: 864 V--GKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVT 921
Query: 808 SKLD--IDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLAFSRGIY 864
L I + +G+F +L + GL++L EH+VY L + N S+L + L S+ ++
Sbjct: 922 ETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRLH 980
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 273 bits (697), Expect = 1e-72
Identities = 222/824 (26%), Positives = 396/824 (48%), Gaps = 66/824 (8%)
Query: 117 VPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSL-HPGH 175
+P+L ++ ++ + K +FL+ Q V F+++ Y W+ ++ S H G
Sbjct: 116 IPVLGLTTRMSIY-SDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGR 174
Query: 176 ALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRARTQRL-LRQLDAPVFVAYCSREEAE 234
A + + + ++L + PG + ++L+A V + S ++A
Sbjct: 175 AAQKRLETLLEERESKAEKVL-----QFDPGTKNVTALLMEAKELEARVIILSASEDDAA 229
Query: 235 VLFAEAAQAGLVGPGHVWLVPNLALGSTD---APPATFPVGLISVVTESWRLSLRQKVRD 291
++ AA + G G+VWLV + AP + LI+ ES +S D
Sbjct: 230 TVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHIS------D 283
Query: 292 GVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWE----GRDFSF 347
V ++A H + P G C V + F R L++ + GR F
Sbjct: 284 AVGVVAQAVHELLEKENITDPPRG-C-VGNTNIWKTGPLFKRVLMSSKYADGVTGR-VEF 340
Query: 348 SPGGYLVQPTMVVIALNRHRLWEM-VGRWEHGVLYMKYPVWPRYSASLQPVVD-SRHLTV 405
+ G ++ L +L ++ + H + + +WP S L +
Sbjct: 341 NEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKI 400
Query: 406 ATLEERPFVIVESPDPGTGGC----VPNTVPCRR---QSNHTFSSGDVAPYTKLCCKGFC 458
T+ + PFV V+ P G C N P ++ + S G CC GFC
Sbjct: 401 VTIHQEPFVYVK-PTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFC 459
Query: 459 IDILKKLARVVKFSYDLYLVTNGKHGKRVR------GVWNGMIGEVYYKRADMAIGSLTI 512
ID+L KLAR + F+Y+++LV +GK G + R WNGM+GE+ +ADM + LTI
Sbjct: 460 IDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTI 519
Query: 513 NEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVF 572
N ER++ ++FS PF G++++V + + +F++P+ +W+++ + + VVA+ ++
Sbjct: 520 NNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVG-LSVHVVAVMLY 578
Query: 573 MFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVW 632
+ + FSP + + ++ A T+ ++W W ++ N+ + PR +++I+ +VW
Sbjct: 579 LLDRFSP--FGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVW 636
Query: 633 AFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNI 692
A FA+I +ASYTANLAAF++ ++ + ++G++D + + P D+ F + TV S +
Sbjct: 637 AGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDK---FIYATVKQSSVDIYF 693
Query: 693 RSNYR--DMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGS 750
R M+ HM K N S +A+ +++ KL AFI+D+AVL + A + C LVT +
Sbjct: 694 RRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--T 749
Query: 751 GKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLS-GICQNEKNEVMSSK 809
G++F +G+GI M+KDS WK+ + L++L+ +G + L+ W+ C + N +
Sbjct: 750 GELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APAT 807
Query: 810 LDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLA----FSRGIYS 865
L +NMAGVF +LVA G+ +F + +K RH Q+ A + + +
Sbjct: 808 LTFENMAGVF--MLVAGGIVAGIFLIFIEIAYK-RHKDARRKQMQLAFAAVNVWRKNLQD 864
Query: 866 CFSGVQSLASP-PRQASPDLTASSAQASVLKMLQAARDMVTTAG 908
SG A P P++ + +S AS K ++++D T G
Sbjct: 865 RKSG---RAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGG 905
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 270 bits (691), Expect = 5e-72
Identities = 210/769 (27%), Positives = 373/769 (48%), Gaps = 58/769 (7%)
Query: 117 VPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSL-HPGH 175
+P+L ++ ++ + K +FL+ Q V F+++ Y W+ ++ S H G
Sbjct: 116 IPVLGLTTRMSIY-SDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGR 174
Query: 176 ALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRARTQRL-LRQLDAPVFVAYCSREEAE 234
A + + + ++L + PG + ++L+A V + S ++A
Sbjct: 175 AAQKRLETLLEERESKAEKVL-----QFDPGTKNVTALLMEAKELEARVIILSASEDDAA 229
Query: 235 VLFAEAAQAGLVGPGHVWLVPNLALGSTD---APPATFPVGLISVVTESWRLSLRQKVRD 291
++ AA + G G+VWLV + AP + LI+ ES +S D
Sbjct: 230 TVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHIS------D 283
Query: 292 GVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWE----GRDFSF 347
V ++A H + P G C V + F R L++ + GR F
Sbjct: 284 AVGVVAQAVHELLEKENITDPPRG-C-VGNTNIWKTGPLFKRVLMSSKYADGVTGR-VEF 340
Query: 348 SPGGYLVQPTMVVIALNRHRLWEM-VGRWEHGVLYMKYPVWPRYSASLQPVVD-SRHLTV 405
+ G ++ L +L ++ + H + + +WP S L +
Sbjct: 341 NEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKI 400
Query: 406 ATLEERPFVIVESPDPGTGGC----VPNTVPCRR---QSNHTFSSGDVAPYTKLCCKGFC 458
T+ + PFV V+ P G C N P ++ + S G CC GFC
Sbjct: 401 VTIHQEPFVYVK-PTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFC 459
Query: 459 IDILKKLARVVKFSYDLYLVTNGKHGKRVR------GVWNGMIGEVYYKRADMAIGSLTI 512
ID+L KLAR + F+Y+++LV +GK G + R WNGM+GE+ +ADM + LTI
Sbjct: 460 IDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTI 519
Query: 513 NEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVF 572
N ER++ ++FS PF G++++V + + +F++P+ +W+++ + + VVA+ ++
Sbjct: 520 NNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVG-LSVHVVAVMLY 578
Query: 573 MFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVW 632
+ + FSP + + ++ A T+ ++W W ++ N+ + PR +++I+ +VW
Sbjct: 579 LLDRFSP--FGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVW 636
Query: 633 AFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNI 692
A FA+I +ASYTANLAAF++ ++ + ++G++D + + P D+ F + TV S +
Sbjct: 637 AGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDK---FIYATVKQSSVDIYF 693
Query: 693 RSNYR--DMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGS 750
R M+ HM K N S +A+ +++ KL AFI+D+AVL + A + C LVT +
Sbjct: 694 RRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--T 749
Query: 751 GKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLS-GICQNEKNEVMSSK 809
G++F +G+GI M+KDS WK+ + L++L+ +G + L+ W+ C + N +
Sbjct: 750 GELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APAT 807
Query: 810 LDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLA 858
L +NMAGVF +LVA G+ +F + +K RH Q+ A
Sbjct: 808 LTFENMAGVF--MLVAGGIVAGIFLIFIEIAYK-RHKDARRKQMQLAFA 853
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 270 bits (691), Expect = 5e-72
Identities = 210/769 (27%), Positives = 373/769 (48%), Gaps = 58/769 (7%)
Query: 117 VPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSL-HPGH 175
+P+L ++ ++ + K +FL+ Q V F+++ Y W+ ++ S H G
Sbjct: 116 IPVLGLTTRMSIY-SDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGR 174
Query: 176 ALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRARTQRL-LRQLDAPVFVAYCSREEAE 234
A + + + ++L + PG + ++L+A V + S ++A
Sbjct: 175 AAQKRLETLLEERESKAEKVL-----QFDPGTKNVTALLMEAKELEARVIILSASEDDAA 229
Query: 235 VLFAEAAQAGLVGPGHVWLVPNLALGSTD---APPATFPVGLISVVTESWRLSLRQKVRD 291
++ AA + G G+VWLV + AP + LI+ ES +S D
Sbjct: 230 TVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHIS------D 283
Query: 292 GVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWE----GRDFSF 347
V ++A H + P G C V + F R L++ + GR F
Sbjct: 284 AVGVVAQAVHELLEKENITDPPRG-C-VGNTNIWKTGPLFKRVLMSSKYADGVTGR-VEF 340
Query: 348 SPGGYLVQPTMVVIALNRHRLWEM-VGRWEHGVLYMKYPVWPRYSASLQPVVD-SRHLTV 405
+ G ++ L +L ++ + H + + +WP S L +
Sbjct: 341 NEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKI 400
Query: 406 ATLEERPFVIVESPDPGTGGC----VPNTVPCRR---QSNHTFSSGDVAPYTKLCCKGFC 458
T+ + PFV V+ P G C N P ++ + S G CC GFC
Sbjct: 401 VTIHQEPFVYVK-PTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFC 459
Query: 459 IDILKKLARVVKFSYDLYLVTNGKHGKRVR------GVWNGMIGEVYYKRADMAIGSLTI 512
ID+L KLAR + F+Y+++LV +GK G + R WNGM+GE+ +ADM + LTI
Sbjct: 460 IDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTI 519
Query: 513 NEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVF 572
N ER++ ++FS PF G++++V + + +F++P+ +W+++ + + VVA+ ++
Sbjct: 520 NNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVG-LSVHVVAVMLY 578
Query: 573 MFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVW 632
+ + FSP + + ++ A T+ ++W W ++ N+ + PR +++I+ +VW
Sbjct: 579 LLDRFSP--FGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVW 636
Query: 633 AFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNI 692
A FA+I +ASYTANLAAF++ ++ + ++G++D + + P D+ F + TV S +
Sbjct: 637 AGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDK---FIYATVKQSSVDIYF 693
Query: 693 RSNYR--DMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGS 750
R M+ HM K N S +A+ +++ KL AFI+D+AVL + A + C LVT +
Sbjct: 694 RRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--T 749
Query: 751 GKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLS-GICQNEKNEVMSSK 809
G++F +G+GI M+KDS WK+ + L++L+ +G + L+ W+ C + N +
Sbjct: 750 GELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APAT 807
Query: 810 LDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLA 858
L +NMAGVF +LVA G+ +F + +K RH Q+ A
Sbjct: 808 LTFENMAGVF--MLVAGGIVAGIFLIFIEIAYK-RHKDARRKQMQLAFA 853
>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
sapiens]
Length = 906
Score = 196 bits (498), Expect = 1e-49
Identities = 198/788 (25%), Positives = 340/788 (43%), Gaps = 99/788 (12%)
Query: 101 TEAVAQILDFISSQTHVPILSISGGSAVV-LTPKEPGSAFLQLGVSLEQQLQ-VLFKVLE 158
++ V I F +T + S G V +TP P Q + L +LQ L +++
Sbjct: 79 SKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQDALISIID 138
Query: 159 EYDWSAFAVITSLHPGHALFLEGVRAVAD-ASHVSWRLLDVVTLELGPGGPRARTQRLLR 217
Y W F I G L ++ V D A+ +W++ V L G R Q L +
Sbjct: 139 HYKWQKFVYIYDADRG----LSVLQKVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEK 194
Query: 218 QLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPP----------- 266
+ + V V C E + + + G G+ +++ NL D
Sbjct: 195 KKERLVVVD-CESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGF 253
Query: 267 --ATFPVGLISVVTESWRLS-LRQKVR--------------DGVAILALGAHSYWRQHGT 309
+ + + + + W+ S R R DGV ++A S RQ
Sbjct: 254 QLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRID 313
Query: 310 LP--APAGDCRVHPGPVSPAREAFYRHLLNVTWEGR--DFSFSPGGYLVQPTMVVIALNR 365
+ AGDC +P R L V +EG + F+ G T+ VI + +
Sbjct: 314 ISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEM-K 372
Query: 366 HRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPDPGTGG 425
H +G W ++ + V +R V T+ E P+V++
Sbjct: 373 HDGIRKIGYWNEDDKFVPAATDAQAGGD-NSSVQNRTYIVTTILEDPYVML--------- 422
Query: 426 CVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGK 485
+++ + F D +G+C+++ ++A+ V +SY L +V++GK+G
Sbjct: 423 ---------KKNANQFEGNDRY-------EGYCVELAAEIAKHVGYSYRLEIVSDGKYGA 466
Query: 486 RVRGV--WNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVAR-SNGTV 542
R WNGM+GE+ Y RAD+A+ LTI R E++DFS PF+ GIS+M+ +
Sbjct: 467 RDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKP 526
Query: 543 SPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVS-YNQNLTRGK----KSGGPAF 597
+FL+P + +W M V V++ +F+ FSP +++ G+ F
Sbjct: 527 GVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEF 585
Query: 598 TIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYI 657
I S+W I +PR + +I+ VW FF +I ++SYTANLAAF+ E+ +
Sbjct: 586 GIFNSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV 644
Query: 658 DTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSN----YRDMHTHMVKFNQ----R 709
+ D Q +GT+ GST+ R + + M T+M R
Sbjct: 645 SPIESAEDLAKQ------TEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVR 698
Query: 710 SVEDALTSLKMGK-LDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSH 768
+ E+ + ++ K A++ ++ + Y+ + + C + +G + GYGIA K S
Sbjct: 699 TTEEGMIRVRKSKGKYAYLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGIATPKGSA 755
Query: 769 WKRAIDLALLQFLGDGETQKLETVWL--SGIC--QNEKNEVMSSKLDIDNMAGVFYMLLV 824
+ ++LA+L+ G KL++ W G C ++ ++ +S L + N+AGVFY+L+
Sbjct: 756 LRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIG 815
Query: 825 AMGLALLV 832
+GLA+LV
Sbjct: 816 GLGLAMLV 823
>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
precursor [Homo sapiens]
Length = 884
Score = 194 bits (494), Expect = 3e-49
Identities = 215/884 (24%), Positives = 364/884 (41%), Gaps = 128/884 (14%)
Query: 14 LFGAWAGLGPGQGEQGMTVAVVF-SSSGPPQAQFRARL----TPQSFLDLPLEIQPLTVG 68
LF + GL G + + +F ++ FR + T + + P + P
Sbjct: 11 LFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDN 70
Query: 69 VNTTNPSSLLTQICGLL--GAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGS 126
+ T N ++ C G + G+ + +V T L S H+ +++ S
Sbjct: 71 IETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHT------LTSFCSALHISLITPS--- 121
Query: 127 AVVLTPKEPGSAF-LQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAV 185
P E S F LQL SL L +L+ Y+W+ F + G+++ ++A+
Sbjct: 122 ----FPTEGESQFVLQLRPSLRG---ALLSLLDHYEWNCFVFLYDTDRGYSI----LQAI 170
Query: 186 AD-ASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAG 244
+ A W + + R + L R+ + FV C E + + + G
Sbjct: 171 MEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKK-FVIDCEIERLQNILEQIVSVG 229
Query: 245 LVGPGHVWLVPNLALGS-------------TDAPPATFPVGLISVVTESWRLSLRQK--- 288
G+ +++ NL T F ++ + + W+ L Q+
Sbjct: 230 KHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWK-KLDQREYP 288
Query: 289 ------------VRDGVAILALGAHSYWRQHGTLP--APAGDCRVHPGPVSPAREAFYRH 334
DGV ++A S RQ + AGDC +P R
Sbjct: 289 GSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERT 348
Query: 335 LLNVTWEGR--DFSFSPGGYLVQPTMVVIALNRHRLWEMVGRW---EHGVLYMKYPVWPR 389
L V +G + F G V TM V L VG W + VL P
Sbjct: 349 LKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGP-RKVGYWNDMDKLVLIQDVPTLGN 407
Query: 390 YSASLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPY 449
+A+ +++R + V T+ E P+V+ + NH G+
Sbjct: 408 DTAA----IENRTVVVTTIMESPYVMYKK-------------------NHEMFEGNDK-- 442
Query: 450 TKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRVRG--VWNGMIGEVYYKRADMAI 507
+G+C+D+ ++A+ + Y + +V +GK+G R +WNGM+GE+ Y +A++AI
Sbjct: 443 ----YEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAI 498
Query: 508 GSLTINEERSEIVDFSVPFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVMMFVMCLTV 566
LTI R E++DFS PF+ GIS+M+ + +FL+P + +W M V
Sbjct: 499 APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIG 557
Query: 567 VAITVFMFEYFSPVSYNQNLTRGKKSGGP-----AFTIGKSVWLLWALVFNNSVPIENPR 621
V++ +F+ FSP ++ K G F I S+W I +PR
Sbjct: 558 VSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDI-SPR 616
Query: 622 GTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFG 681
+ +I+ VW FF +I ++SYTANLAAF+ E+ + + D Q +G
Sbjct: 617 SLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYG 670
Query: 682 TVPNGSTERNIRSN----YRDMHTHMVK-----FNQRSVEDALTSLKMGKLDAFIYDAAV 732
T+ +GST+ R + Y M T+M F + + E K AF+ ++ +
Sbjct: 671 TLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTM 730
Query: 733 LNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETV 792
Y+ + + C + +G + GYG+A K S A++LA+L+ G KL+
Sbjct: 731 NEYIEQR-KPCDTMKVGGN--LDSKGYGVATPKGSSLGNAVNLAVLKLNEQGLLDKLKNK 787
Query: 793 WL--SGICQN--EKNEVMSSKLDIDNMAGVFYMLLVAMGLALLV 832
W G C + ++ +S L + N+AGVFY+L+ +GLA+LV
Sbjct: 788 WWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLV 831
>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
sapiens]
Length = 906
Score = 194 bits (493), Expect = 4e-49
Identities = 198/788 (25%), Positives = 338/788 (42%), Gaps = 99/788 (12%)
Query: 101 TEAVAQILDFISSQTHVPILSISGGSAVV-LTPKEPGSAFLQLGVSLEQQLQ-VLFKVLE 158
++ V I F +T + S G V +TP P Q + L +LQ L +++
Sbjct: 79 SKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQDALISIID 138
Query: 159 EYDWSAFAVITSLHPGHALFLEGVRAVAD-ASHVSWRLLDVVTLELGPGGPRARTQRLLR 217
Y W F I G L ++ V D A+ +W++ V L G R Q L +
Sbjct: 139 HYKWQKFVYIYDADRG----LSVLQKVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEK 194
Query: 218 QLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPP----------- 266
+ + V V C E + + + G G+ +++ NL D
Sbjct: 195 KKERLVVVD-CESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGF 253
Query: 267 --ATFPVGLISVVTESWRLS-LRQKVR--------------DGVAILALGAHSYWRQHGT 309
+ + + + + W+ S R R DGV ++A S RQ
Sbjct: 254 QLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRID 313
Query: 310 LP--APAGDCRVHPGPVSPAREAFYRHLLNVTWEGR--DFSFSPGGYLVQPTMVVIALNR 365
+ AGDC +P R L V +EG + F+ G T+ VI + +
Sbjct: 314 ISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEM-K 372
Query: 366 HRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPDPGTGG 425
H +G W ++ + V +R V T+ E P+V++
Sbjct: 373 HDGIRKIGYWNEDDKFVPAATDAQAGGD-NSSVQNRTYIVTTILEDPYVML--------- 422
Query: 426 CVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGK 485
+++ + F D +G+C+++ ++A+ V +SY L +V++GK+G
Sbjct: 423 ---------KKNANQFEGNDRY-------EGYCVELAAEIAKHVGYSYRLEIVSDGKYGA 466
Query: 486 RVRGV--WNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVAR-SNGTV 542
R WNGM+GE+ Y RAD+A+ LTI R E++DFS PF+ GIS+M+ +
Sbjct: 467 RDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKP 526
Query: 543 SPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVS-YNQNLTRGK----KSGGPAF 597
+FL+P + +W M V V++ +F+ FSP +++ G+ F
Sbjct: 527 GVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEF 585
Query: 598 TIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYI 657
I S+W I +PR + +I+ VW FF +I ++SYTANLAAF+ E+ +
Sbjct: 586 GIFNSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV 644
Query: 658 DTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSN----YRDMHTHMVKFNQ----R 709
+ D Q +GT+ GST+ R + + M T+M R
Sbjct: 645 SPIESAEDLAKQ------TEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVR 698
Query: 710 SVEDALTSLKMGK-LDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSH 768
+ E+ + ++ K A++ ++ + Y+ + + C + +G + GYGIA K S
Sbjct: 699 TTEEGMIRVRKSKGKYAYLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGIATPKGSA 755
Query: 769 WKRAIDLALLQFLGDGETQKLETVWL--SGICQN--EKNEVMSSKLDIDNMAGVFYMLLV 824
+ ++LA+L+ G KL+ W G C + ++ +S L + N+AGVFY+L+
Sbjct: 756 LRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIG 815
Query: 825 AMGLALLV 832
+GLA+LV
Sbjct: 816 GLGLAMLV 823
>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
precursor [Homo sapiens]
Length = 902
Score = 194 bits (492), Expect = 6e-49
Identities = 214/884 (24%), Positives = 364/884 (41%), Gaps = 128/884 (14%)
Query: 14 LFGAWAGLGPGQGEQGMTVAVVF-SSSGPPQAQFRARL----TPQSFLDLPLEIQPLTVG 68
LF + GL G + + +F ++ FR + T + + P + P
Sbjct: 11 LFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDN 70
Query: 69 VNTTNPSSLLTQICGLL--GAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGS 126
+ T N ++ C G + G+ + +V T L S H+ +++ S
Sbjct: 71 IETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHT------LTSFCSALHISLITPS--- 121
Query: 127 AVVLTPKEPGSAF-LQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAV 185
P E S F LQL SL L +L+ Y+W+ F + G+++ ++A+
Sbjct: 122 ----FPTEGESQFVLQLRPSLRG---ALLSLLDHYEWNCFVFLYDTDRGYSI----LQAI 170
Query: 186 AD-ASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAG 244
+ A W + + R + L R+ + FV C E + + + G
Sbjct: 171 MEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKK-FVIDCEIERLQNILEQIVSVG 229
Query: 245 LVGPGHVWLVPNLALGS-------------TDAPPATFPVGLISVVTESWRLSLRQK--- 288
G+ +++ NL T F ++ + + W+ L Q+
Sbjct: 230 KHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWK-KLDQREYP 288
Query: 289 ------------VRDGVAILALGAHSYWRQHGTLP--APAGDCRVHPGPVSPAREAFYRH 334
DGV ++A S RQ + AGDC +P R
Sbjct: 289 GSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERT 348
Query: 335 LLNVTWEGR--DFSFSPGGYLVQPTMVVIALNRHRLWEMVGRW---EHGVLYMKYPVWPR 389
L V +G + F G V TM V L VG W + VL P
Sbjct: 349 LKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGP-RKVGYWNDMDKLVLIQDVPTLGN 407
Query: 390 YSASLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPY 449
+A+ +++R + V T+ E P+V+ + NH G+
Sbjct: 408 DTAA----IENRTVVVTTIMESPYVMYKK-------------------NHEMFEGNDK-- 442
Query: 450 TKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRVRG--VWNGMIGEVYYKRADMAI 507
+G+C+D+ ++A+ + Y + +V +GK+G R +WNGM+GE+ Y +A++AI
Sbjct: 443 ----YEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAI 498
Query: 508 GSLTINEERSEIVDFSVPFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVMMFVMCLTV 566
LTI R E++DFS PF+ GIS+M+ + +FL+P + +W M V
Sbjct: 499 APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIG 557
Query: 567 VAITVFMFEYFSPVSYNQNLTRGKKSGGP-----AFTIGKSVWLLWALVFNNSVPIENPR 621
V++ +F+ FSP ++ K G F I S+W I +PR
Sbjct: 558 VSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDI-SPR 616
Query: 622 GTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFG 681
+ +I+ VW FF +I ++SYTANLAAF+ E+ + + D Q +G
Sbjct: 617 SLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYG 670
Query: 682 TVPNGSTERNIRSN----YRDMHTHMVK-----FNQRSVEDALTSLKMGKLDAFIYDAAV 732
T+ +GST+ R + Y M T+M F + + E K AF+ ++ +
Sbjct: 671 TLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTM 730
Query: 733 LNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETV 792
Y+ + + C + +G + GYG+A K S ++LA+L+ G KL+
Sbjct: 731 NEYIEQR-KPCDTMKVGGN--LDSKGYGVATPKGSSLGTPVNLAVLKLSEAGVLDKLKNK 787
Query: 793 WL--SGIC--QNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLV 832
W G C ++ ++ +S L + N+AGVFY+L+ +GLA+LV
Sbjct: 788 WWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLV 831
>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
sapiens]
Length = 836
Score = 182 bits (462), Expect = 2e-45
Identities = 191/792 (24%), Positives = 335/792 (42%), Gaps = 103/792 (13%)
Query: 101 TEAVAQILDFISSQTHVPILSISGGSAV-VLTPKEPGSAFLQLGVSLEQQLQ-VLFKVLE 158
+ V I F ++ I S G V +TP P + + L+ L ++E
Sbjct: 35 SRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIE 94
Query: 159 EYDWSAFAVITSLHPGHALFLEGVRAVAD-ASHVSWRLLDVVTLELGPGGPRARTQRLLR 217
Y W FA + G L ++AV D A+ W++ + + + L +
Sbjct: 95 YYQWDKFAYLYDSDRG----LSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQ 150
Query: 218 QLDAPV---FVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTD--------APP 266
L+ + C R++ + + G G+ +++ NL D A
Sbjct: 151 DLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANV 210
Query: 267 ATFPV-----GLISVVTESWRLSLRQK----------------VRDGVAILALGAHSYWR 305
+ F + L+S E W +L +K D V ++ + +
Sbjct: 211 SGFQIVDYDDSLVSKFIERWS-TLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRK 269
Query: 306 QHGTLP--APAGDCRVHPGPVSPAREAFYRHLLNVTWEGR--DFSFSPGGYLVQPTMVVI 361
Q + AGDC +P R L V EG + F G + T+ ++
Sbjct: 270 QRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIM 329
Query: 362 ALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPDP 421
L + +G W V M + S + ++++ + V T+ E P+V+++
Sbjct: 330 ELKTNGP-RKIGYWSE-VDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKK--- 384
Query: 422 GTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNG 481
NH G+ +G+C+D+ ++A+ F Y L +V +G
Sbjct: 385 ----------------NHEMLEGNER------YEGYCVDLAAEIAKHCGFKYKLTIVGDG 422
Query: 482 KHGKRVRG--VWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVAR-S 538
K+G R +WNGM+GE+ Y +AD+AI LTI R E++DFS PF+ GIS+M+ +
Sbjct: 423 KYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 482
Query: 539 NGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYN-QNLTRGKKSGGP-- 595
+FL+P + +W M V V++ +F+ FSP ++ + G+++
Sbjct: 483 KSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSES 541
Query: 596 --AFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQ 653
F I S+W I +PR + +I+ VW FF +I ++SYTANLAAF+
Sbjct: 542 TNEFGIFNSLWFSLGAFMRQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 600
Query: 654 EQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSN----YRDMHTHMVK---- 705
E+ + + D Q +GT+ +GST+ R + + M T+M
Sbjct: 601 ERMVSPIESAEDLSKQ------TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPS 654
Query: 706 -FNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQ 764
F + + E K A++ ++ + Y+ + + C + +G + GYGIA
Sbjct: 655 VFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGIATP 711
Query: 765 KDSHWKRAIDLALLQFLGDGETQKLETVWL--SGIC--QNEKNEVMSSKLDIDNMAGVFY 820
K S + ++LA+L+ G KL+ W G C ++ ++ +S L + N+AGVFY
Sbjct: 712 KGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFY 771
Query: 821 MLLVAMGLALLV 832
+L+ +GLA+LV
Sbjct: 772 ILVGGLGLAMLV 783
>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
precursor [Homo sapiens]
Length = 883
Score = 182 bits (462), Expect = 2e-45
Identities = 192/792 (24%), Positives = 335/792 (42%), Gaps = 103/792 (13%)
Query: 101 TEAVAQILDFISSQTHVPILSISGGSAV-VLTPKEPGSAFLQLGVSLEQQLQ-VLFKVLE 158
+ V I F ++ I S G V +TP P + + L+ L ++E
Sbjct: 82 SRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIE 141
Query: 159 EYDWSAFAVITSLHPGHALFLEGVRAVAD-ASHVSWRLLDVVTLELGPGGPRARTQRLLR 217
Y W FA + G L ++AV D A+ W++ + + + L +
Sbjct: 142 YYQWDKFAYLYDSDRG----LSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQ 197
Query: 218 QLDAPV---FVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTD--------APP 266
L+ + C R++ + + G G+ +++ NL D A
Sbjct: 198 DLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANV 257
Query: 267 ATFPV-----GLISVVTESWRLSLRQK----------------VRDGVAILALGAHSYWR 305
+ F + L+S E W +L +K D V ++ + +
Sbjct: 258 SGFQIVDYDDSLVSKFIERWS-TLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRK 316
Query: 306 QHGTLP--APAGDCRVHPGPVSPAREAFYRHLLNVTWEGR--DFSFSPGGYLVQPTMVVI 361
Q + AGDC +P R L V EG + F G + T+ ++
Sbjct: 317 QRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIM 376
Query: 362 ALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPDP 421
L + +G W V M + S + ++++ + V T+ E P+V+++
Sbjct: 377 ELKTNGP-RKIGYWSE-VDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKK--- 431
Query: 422 GTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNG 481
NH G+ +G+C+D+ ++A+ F Y L +V +G
Sbjct: 432 ----------------NHEMLEGNER------YEGYCVDLAAEIAKHCGFKYKLTIVGDG 469
Query: 482 KHGKRVRG--VWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVAR-S 538
K+G R +WNGM+GE+ Y +AD+AI LTI R E++DFS PF+ GIS+M+ +
Sbjct: 470 KYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 529
Query: 539 NGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYN-QNLTRGKKSGGP-- 595
+FL+P + +W M V V++ +F+ FSP ++ + G+++
Sbjct: 530 KSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSES 588
Query: 596 --AFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQ 653
F I S+W I +PR + +I+ VW FF +I ++SYTANLAAF+
Sbjct: 589 TNEFGIFNSLWFSLGAFMRQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 647
Query: 654 EQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSN----YRDMHTHMVK---- 705
E+ + + D Q +GT+ +GST+ R + + M T+M
Sbjct: 648 ERMVSPIESAEDLSKQ------TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPS 701
Query: 706 -FNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQ 764
F + + E K A++ ++ + Y+ + + C + +G + GYGIA
Sbjct: 702 VFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGIATP 758
Query: 765 KDSHWKRAIDLALLQFLGDGETQKLETVWL--SGICQN--EKNEVMSSKLDIDNMAGVFY 820
K S + A++LA+L+ G KL+ W G C + ++ +S L + N+AGVFY
Sbjct: 759 KGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFY 818
Query: 821 MLLVAMGLALLV 832
+L+ +GLA+LV
Sbjct: 819 ILVGGLGLAMLV 830
>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
precursor [Homo sapiens]
Length = 883
Score = 182 bits (462), Expect = 2e-45
Identities = 191/792 (24%), Positives = 335/792 (42%), Gaps = 103/792 (13%)
Query: 101 TEAVAQILDFISSQTHVPILSISGGSAV-VLTPKEPGSAFLQLGVSLEQQLQ-VLFKVLE 158
+ V I F ++ I S G V +TP P + + L+ L ++E
Sbjct: 82 SRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIE 141
Query: 159 EYDWSAFAVITSLHPGHALFLEGVRAVAD-ASHVSWRLLDVVTLELGPGGPRARTQRLLR 217
Y W FA + G L ++AV D A+ W++ + + + L +
Sbjct: 142 YYQWDKFAYLYDSDRG----LSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQ 197
Query: 218 QLDAPV---FVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTD--------APP 266
L+ + C R++ + + G G+ +++ NL D A
Sbjct: 198 DLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANV 257
Query: 267 ATFPV-----GLISVVTESWRLSLRQK----------------VRDGVAILALGAHSYWR 305
+ F + L+S E W +L +K D V ++ + +
Sbjct: 258 SGFQIVDYDDSLVSKFIERWS-TLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRK 316
Query: 306 QHGTLP--APAGDCRVHPGPVSPAREAFYRHLLNVTWEGR--DFSFSPGGYLVQPTMVVI 361
Q + AGDC +P R L V EG + F G + T+ ++
Sbjct: 317 QRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIM 376
Query: 362 ALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPDP 421
L + +G W V M + S + ++++ + V T+ E P+V+++
Sbjct: 377 ELKTNGP-RKIGYWSE-VDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKK--- 431
Query: 422 GTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNG 481
NH G+ +G+C+D+ ++A+ F Y L +V +G
Sbjct: 432 ----------------NHEMLEGNER------YEGYCVDLAAEIAKHCGFKYKLTIVGDG 469
Query: 482 KHGKRVRG--VWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVAR-S 538
K+G R +WNGM+GE+ Y +AD+AI LTI R E++DFS PF+ GIS+M+ +
Sbjct: 470 KYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 529
Query: 539 NGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYN-QNLTRGKKSGGP-- 595
+FL+P + +W M V V++ +F+ FSP ++ + G+++
Sbjct: 530 KSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSES 588
Query: 596 --AFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQ 653
F I S+W I +PR + +I+ VW FF +I ++SYTANLAAF+
Sbjct: 589 TNEFGIFNSLWFSLGAFMRQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 647
Query: 654 EQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSN----YRDMHTHMVK---- 705
E+ + + D Q +GT+ +GST+ R + + M T+M
Sbjct: 648 ERMVSPIESAEDLSKQ------TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPS 701
Query: 706 -FNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQ 764
F + + E K A++ ++ + Y+ + + C + +G + GYGIA
Sbjct: 702 VFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGIATP 758
Query: 765 KDSHWKRAIDLALLQFLGDGETQKLETVWL--SGIC--QNEKNEVMSSKLDIDNMAGVFY 820
K S + ++LA+L+ G KL+ W G C ++ ++ +S L + N+AGVFY
Sbjct: 759 KGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFY 818
Query: 821 MLLVAMGLALLV 832
+L+ +GLA+LV
Sbjct: 819 ILVGGLGLAMLV 830
>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
Length = 956
Score = 176 bits (446), Expect = 1e-43
Identities = 163/643 (25%), Positives = 290/643 (45%), Gaps = 113/643 (17%)
Query: 275 SVVTESWRLSLRQKVRDGVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRH 334
+VVT L+ Q++ GV L+ G+ W QHGT + +
Sbjct: 314 AVVTAVQELNRSQEI--GVKPLSCGSAQIW-QHGT--------------------SLMNY 350
Query: 335 LLNVTWEGRD--FSFSPGGYLVQPTMVVIALNRHRLWEMVGRWE--HGVLYMKYPVWPRY 390
L V EG F+ G + ++ R+ + +G+W G+ + Y
Sbjct: 351 LRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNG-FRQIGQWHVAEGLSMDSH----LY 405
Query: 391 SASLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPYT 450
++++ + + L V T+ E P+++++ NH G+
Sbjct: 406 ASNISDTLFNTTLVVTTILENPYLMLKG-------------------NHQEMEGNDR--- 443
Query: 451 KLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHG-KRVRGVWNGMIGEVYYKRADMAIGS 509
+GFC+D+LK+LA +++F+Y + LV +G +G G W GM+GE+ ++AD+A+
Sbjct: 444 ---YEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAG 500
Query: 510 LTINEERSEIVDFSVPFVETGISVM----VARSNGTVSPSAFLEPYSPAVWVMMF----- 560
LTI ER +++DFS PF+ GIS++ + R G S FL+P+SP VW+ M
Sbjct: 501 LTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPGVWLFMLLAYLA 557
Query: 561 VMCLTVVAITVFMFEYFSPVSYNQ---NLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPI 617
V C+ + + +E++SP Q NL + +++G S+W I
Sbjct: 558 VSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQ------YSLGNSLWFPVGGFMQQGSTI 611
Query: 618 ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQY---IDTVSGLSDKKFQRPQDQ 674
PR +++ + VW F +I ++SYTANLAAF+ ++ I++V L+D+
Sbjct: 612 A-PRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQ-------- 662
Query: 675 YPPFRFGTVPNGST----ERNIRSNYRDMHTHMVKFNQ----RSVEDALTSLKMGKLDAF 726
+GT+ GS+ + + Y+ M +M +S E+ + + + AF
Sbjct: 663 -TAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARV-LNSNYAF 720
Query: 727 IYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGET 786
+ ++ + Y + C L IG + T GYGI M S ++ DLA+LQ +
Sbjct: 721 LLESTMNEYY--RQRNCNLTQIGG--LLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRL 776
Query: 787 QKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHS 846
+ L+ W G ++ + + L ++N+ G+F +L+ + +A+ + E L W LRHS
Sbjct: 777 EILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFL--WTLRHS 834
Query: 847 -VPNSSQLDFLLAFSRGIYSCFSGV-----QSLASPPRQASPD 883
S ++ R I C + ++ PPR P+
Sbjct: 835 EATEVSVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPE 877
>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
precursor [Homo sapiens]
Length = 918
Score = 174 bits (442), Expect = 4e-43
Identities = 133/494 (26%), Positives = 243/494 (49%), Gaps = 70/494 (14%)
Query: 361 IALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD 420
++ + +++W+ +G W S+++ + +R L V T+ E P+V+ D
Sbjct: 407 VSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSD 466
Query: 421 PGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTN 480
G N F +G+C+D+LK+L+ ++ F YD+ LV +
Sbjct: 467 KPLYG------------NDRF-------------EGYCLDLLKELSNILGFIYDVKLVPD 501
Query: 481 GKHG-KRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSN 539
GK+G + +G WNGM+ E+ RAD+A+ LTI R +++DFS PF+ GIS++ + N
Sbjct: 502 GKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPN 561
Query: 540 GTVSPS--AFLEPYSPAVWVMMFVMCLTVVAITVFM-----FEYFSPVSYNQNLTRGKKS 592
GT +P +FL P SP +W+ + + CL V + + +E+++P N + + +
Sbjct: 562 GT-NPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENN 620
Query: 593 GGPAFTIGKSVWL-LWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFM 651
FT+ S W + AL+ S + P+ +++I+ +W FF +I ++SYTANLAAF+
Sbjct: 621 ----FTLLNSFWFGVGALMQQGSELM--PKALSTRIVGGIWWFFTLIIISSYTANLAAFL 674
Query: 652 IQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGST----ERNIRSNYRDM-------- 699
E+ + D Q +G V +GST +++ S Y M
Sbjct: 675 TVERMESPIDSADDLAKQTK------IEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQ 728
Query: 700 HTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGY 759
T +V+ + ++ LT+ A + ++ + Y+ ++ C L IG + + GY
Sbjct: 729 QTALVRNSDEGIQRVLTTDY-----ALLMESTSIEYVTQRN--CNLTQIGG--LIDSKGY 779
Query: 760 GIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVF 819
G+ S ++ I +A+LQ +G+ ++ W G E++ +S L ++N+ G+F
Sbjct: 780 GVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIF 839
Query: 820 YMLLVAMGLALLVF 833
+++A GL L VF
Sbjct: 840 --IVLAAGLVLSVF 851
>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
precursor [Homo sapiens]
Length = 894
Score = 172 bits (437), Expect = 1e-42
Identities = 120/401 (29%), Positives = 202/401 (50%), Gaps = 34/401 (8%)
Query: 455 KGFCIDILKKLARVVKFSYDLYLVTNGKHGKR--VRGVWNGMIGEVYYKRADMAIGSLTI 512
+G+C+D+ ++A+ V+ Y L +V +GK+G R +WNGM+GE+ Y RAD+A+ LTI
Sbjct: 452 EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTI 511
Query: 513 NEERSEIVDFSVPFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITV 571
R E++DFS PF+ GIS+M+ + +FL+P + +W M V V++ +
Sbjct: 512 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 570
Query: 572 FMFEYFSPVSYN--QNLTRGKKSGGP-----AFTIGKSVWLLWALVFNNSVPIENPRGTT 624
F+ FSP ++ N + P F I S+W I +PR +
Sbjct: 571 FLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDI-SPRSLS 629
Query: 625 SKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVP 684
+I+ VW FF +I ++SYTANLAAF+ E+ + + D Q +GT+
Sbjct: 630 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLD 683
Query: 685 NGSTERNIRSN----YRDMHTHMVK-----FNQRSVEDALTSLKMGKLDAFIYDAAVLNY 735
+GST+ R + Y M ++M F + + + K AF+ ++ + Y
Sbjct: 684 SGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEY 743
Query: 736 MAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWL- 794
+ + + C + +G + GYG+A K S A++LA+L+ G KL+ W
Sbjct: 744 IEQR-KPCDTMKVGGN--LDSKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWY 800
Query: 795 -SGICQN--EKNEVMSSKLDIDNMAGVFYMLLVAMGLALLV 832
G C + ++ +S L + N+AGVFY+L+ +GLA++V
Sbjct: 801 DKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMV 841
>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
precursor [Homo sapiens]
Length = 894
Score = 172 bits (436), Expect = 2e-42
Identities = 119/401 (29%), Positives = 202/401 (50%), Gaps = 34/401 (8%)
Query: 455 KGFCIDILKKLARVVKFSYDLYLVTNGKHGKR--VRGVWNGMIGEVYYKRADMAIGSLTI 512
+G+C+D+ ++A+ V+ Y L +V +GK+G R +WNGM+GE+ Y RAD+A+ LTI
Sbjct: 452 EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTI 511
Query: 513 NEERSEIVDFSVPFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITV 571
R E++DFS PF+ GIS+M+ + +FL+P + +W M V V++ +
Sbjct: 512 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 570
Query: 572 FMFEYFSPVSYN--QNLTRGKKSGGP-----AFTIGKSVWLLWALVFNNSVPIENPRGTT 624
F+ FSP ++ N + P F I S+W I +PR +
Sbjct: 571 FLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDI-SPRSLS 629
Query: 625 SKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVP 684
+I+ VW FF +I ++SYTANLAAF+ E+ + + D Q +GT+
Sbjct: 630 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLD 683
Query: 685 NGSTERNIRSN----YRDMHTHMVK-----FNQRSVEDALTSLKMGKLDAFIYDAAVLNY 735
+GST+ R + Y M ++M F + + + K AF+ ++ + Y
Sbjct: 684 SGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEY 743
Query: 736 MAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWL- 794
+ + + C + +G + GYG+A K S ++LA+L+ G KL+ W
Sbjct: 744 IEQR-KPCDTMKVGGN--LDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWY 800
Query: 795 -SGIC--QNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLV 832
G C ++ ++ +S L + N+AGVFY+L+ +GLA++V
Sbjct: 801 DKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMV 841
>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
Length = 980
Score = 172 bits (436), Expect = 2e-42
Identities = 152/562 (27%), Positives = 249/562 (44%), Gaps = 62/562 (11%)
Query: 455 KGFCIDILKKLARVVKFSYDLYLVTNGKHGK-RVRGVWNGMIGEVYYKRADMAIGSLTIN 513
+GFC+D+L++LA +++F Y L LV +G +G G W GM+GE+ ++AD+A+ + TI
Sbjct: 444 EGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTIT 503
Query: 514 EERSEIVDFSVPFVETGISVM----VARSNGTVSPSAFLEPYSPAVWVMMF-----VMCL 564
ER +++DFS PF+ GIS++ + R G S FL+P+SPAVW+ M V C+
Sbjct: 504 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPAVWLFMLLAYLAVSCV 560
Query: 565 TVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTT 624
+A + +E+++P + L +T+G S+W I PR +
Sbjct: 561 LFLAARLSPYEWYNP---HPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEI-MPRALS 616
Query: 625 SKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVP 684
++ + VW F +I ++SYTANLAAF+ ++ V D Q +GT+
Sbjct: 617 TRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQ------TNIEYGTIH 670
Query: 685 NGSTERNIRSNYRDMHTHMVKFNQ--------RSVEDALTSLKMGKLDAFIYDAAVLNYM 736
GST +++ + M + Q +S E+ + + + AF+ ++ + Y
Sbjct: 671 AGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARV-LNSRYAFLLESTMNEY- 728
Query: 737 AGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSG 796
+ C L IG + T GYGI M S ++ I LA+LQ + + L+ W G
Sbjct: 729 -HRRLNCNLTQIGG--LLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEG 785
Query: 797 ICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNS--SQLD 854
++ + + L ++N+ G+F +L+ + +A+ V E + W R S + S
Sbjct: 786 GRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFI--WSTRRSAESEEVSVCQ 843
Query: 855 FLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAARDMVTTAGVSSSLD 914
+L R SC + + R+ P + L L+A R+M + G S
Sbjct: 844 EMLQELRHAVSC----RKTSRSRRRRRP-----GGPSRALLSLRAVREMRLSNGKLYSAG 894
Query: 915 RATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEP----------SPTGWGPPD 964
GG +R P P SG P PTP +G G P
Sbjct: 895 AGGDAGSAHGGPQRLLDD---PGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPP 951
Query: 965 GGRAALVRRAPQPPGRPPTPGP 986
G P RP GP
Sbjct: 952 RGLGVPAEATSPPRPRPGPAGP 973
>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
[Homo sapiens]
Length = 919
Score = 172 bits (435), Expect = 2e-42
Identities = 156/576 (27%), Positives = 261/576 (45%), Gaps = 71/576 (12%)
Query: 331 FYRHLLNVTWEG---RDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRWEHGVLYMKYPVW 387
F + WEG R G + +I+L L E VG W V
Sbjct: 362 FMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGL-EKVGVWSPADGLNITEVA 420
Query: 388 PRYSASLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVA 447
++ + +R L V T+ E PFV+ R+S+ T D
Sbjct: 421 KGRGPNVTDSLTNRSLIVTTVLEEPFVMF------------------RKSDRTLYGNDRF 462
Query: 448 PYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRV-RGVWNGMIGEVYYKRADMA 506
+G+CID+LK+LA ++ FSY++ LV +GK+G + +G WNGM+ E+ +AD+A
Sbjct: 463 -------EGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLA 515
Query: 507 IGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMMFVMCL 564
+ LTI R + +DFS PF+ G+S++ + NGT +PS +FL P SP +W+ + + L
Sbjct: 516 VAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGT-NPSVFSFLNPLSPDIWMYVLLAYL 574
Query: 565 TVVAITVFMFEYFSPVSY--NQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRG 622
V + +F+ FSP + G + FT+ S W + + P+
Sbjct: 575 GVSCV-LFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSEL-MPKA 632
Query: 623 TTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGT 682
+++I+ +W FF +I ++SYTANLAAF+ E+ + D Q +G
Sbjct: 633 LSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ------TKIEYGA 686
Query: 683 VPNGST----ERNIRSNYRDMHTHM-------VKFNQRSVEDALTSLKMGKLDAFIYDAA 731
V +G+T +++ S + M M VK N+ ++ ALT+ A + ++
Sbjct: 687 VKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADY-----ALLMEST 741
Query: 732 VLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLET 791
+ Y+ ++ C L IG + + GYGI S ++ I +A+LQ + + ++
Sbjct: 742 TIEYVTQRN--CNLTQIGG--LIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKE 797
Query: 792 VWLSGI-CQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNS 850
W G C E+N+ +S L I + G+F +L + L++LV E + +KLR +
Sbjct: 798 KWWRGSGCPEEENK-EASALGIQKIGGIFIVLAAGLVLSVLVAVGEFV--YKLRKTA-ER 853
Query: 851 SQLDFLLAFS---RGIYSCFSGVQSLASPPRQASPD 883
Q F + R +C V+ PP D
Sbjct: 854 EQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTD 889
>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
precursor [Homo sapiens]
Length = 869
Score = 171 bits (433), Expect = 4e-42
Identities = 137/516 (26%), Positives = 242/516 (46%), Gaps = 70/516 (13%)
Query: 360 VIALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESP 419
VI+L L E +G W+ A++ + +R L V T+ E P+V+ +
Sbjct: 391 VISLKEEGL-EKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKS 449
Query: 420 DPGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVT 479
D G N F +G+CID+L++L+ ++ F+Y++ LV
Sbjct: 450 DKPLYG------------NDRF-------------EGYCIDLLRELSTILGFTYEIRLVE 484
Query: 480 NGKHGKR--VRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVAR 537
+GK+G + G WNGM+ E+ +AD+A+ L I R +++DFS PF+ GIS++ +
Sbjct: 485 DGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRK 544
Query: 538 SNGTVSPS--AFLEPYSPAVWVMMF-----VMCLTVVAITVFMFEYFSPVSYNQNLTRGK 590
NGT +P +FL P SP +W+ + V C+ V +E+++P N + +
Sbjct: 545 PNGT-NPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVE 603
Query: 591 KSGGPAFTIGKSVWL-LWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAA 649
+ FT+ S W + AL+ S + P+ +++I+ +W FF +I ++SYTANLAA
Sbjct: 604 NN----FTLLNSFWFGVGALMQQGSELM--PKALSTRIVGGIWWFFTLIIISSYTANLAA 657
Query: 650 FMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGST----ERNIRSNYRDMHTHM-- 703
F+ E+ + D Q +G V +G+T +++ S Y M M
Sbjct: 658 FLTVERMESPIDSADDLAKQ------TKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSS 711
Query: 704 ------VKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATT 757
VK N+ ++ LTS AF+ ++ + ++ ++ C L IG + +
Sbjct: 712 RRQSVLVKSNEEGIQRVLTSDY-----AFLMESTTIEFVTQRN--CNLTQIGG--LIDSK 762
Query: 758 GYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAG 817
GYG+ S ++ I +A+LQ +G+ ++ W G E+ +S L + N+ G
Sbjct: 763 GYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGG 822
Query: 818 VFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQL 853
+F +L + L++ V E L K + S +
Sbjct: 823 IFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKESSI 858
>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
precursor [Homo sapiens]
Length = 905
Score = 171 bits (433), Expect = 4e-42
Identities = 130/464 (28%), Positives = 232/464 (50%), Gaps = 70/464 (15%)
Query: 391 SASLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPYT 450
S+++ + +R L V T+ E P+V+ D G N F
Sbjct: 422 SSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYG------------NDRF--------- 460
Query: 451 KLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHG-KRVRGVWNGMIGEVYYKRADMAIGS 509
+G+C+D+LK+L+ ++ F YD+ LV +GK+G + +G WNGM+ E+ RAD+A+
Sbjct: 461 ----EGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAP 516
Query: 510 LTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMMFVMCLTVV 567
LTI R +++DFS PF+ GIS++ + NGT +P +FL P SP +W+ + + CL V
Sbjct: 517 LTITYVREKVIDFSKPFMTLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYVLLACLGVS 575
Query: 568 AITVFM-----FEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWL-LWALVFNNSVPIENPR 621
+ + +E+++P N + + + FT+ S W + AL+ S + P+
Sbjct: 576 CVLFVIARFTPYEWYNPHPCNPDSDVVENN----FTLLNSFWFGVGALMQQGSELM--PK 629
Query: 622 GTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFG 681
+++I+ +W FF +I ++SYTANLAAF+ E+ + D Q +G
Sbjct: 630 ALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTK------IEYG 683
Query: 682 TVPNGST----ERNIRSNYRDM--------HTHMVKFNQRSVEDALTSLKMGKLDAFIYD 729
V +GST +++ S Y M T +V+ + ++ LT+ A + +
Sbjct: 684 AVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDY-----ALLME 738
Query: 730 AAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKL 789
+ + Y+ ++ C L IG + + GYG+ S ++ I +A+LQ +G+ +
Sbjct: 739 STSIEYVTQRN--CNLTQIGG--LIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMM 794
Query: 790 ETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVF 833
+ W G E++ +S L ++N+ G+F +++A GL L VF
Sbjct: 795 KEKWWRGNGCPEEDNKEASALGVENIGGIF--IVLAAGLVLSVF 836
>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
precursor [Homo sapiens]
Length = 908
Score = 171 bits (432), Expect = 5e-42
Identities = 136/496 (27%), Positives = 238/496 (47%), Gaps = 72/496 (14%)
Query: 360 VIALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESP 419
VI+L L E +G W+ A++ + +R L V T+ E P+V+ +
Sbjct: 391 VISLKEEGL-EKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKS 449
Query: 420 DPGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVT 479
D G N F +G+CID+L++L+ ++ F+Y++ LV
Sbjct: 450 DKPLYG------------NDRF-------------EGYCIDLLRELSTILGFTYEIRLVE 484
Query: 480 NGKHGKR--VRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVAR 537
+GK+G + G WNGM+ E+ +AD+A+ L I R +++DFS PF+ GIS++ +
Sbjct: 485 DGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRK 544
Query: 538 SNGTVSPS--AFLEPYSPAVWVMMF-----VMCLTVVAITVFMFEYFSPVSYNQNLTRGK 590
NGT +P +FL P SP +W+ + V C+ V +E+++P N + +
Sbjct: 545 PNGT-NPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVE 603
Query: 591 KSGGPAFTIGKSVWL-LWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAA 649
+ FT+ S W + AL+ S + P+ +++I+ +W FF +I ++SYTANLAA
Sbjct: 604 NN----FTLLNSFWFGVGALMQQGSELM--PKALSTRIVGGIWWFFTLIIISSYTANLAA 657
Query: 650 FMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGST----ERNIRSNYRDMHTHM-- 703
F+ E+ + D Q +G V +G+T +++ S Y M M
Sbjct: 658 FLTVERMESPIDSADDLAKQTK------IEYGAVEDGATMTFFKKSKISTYDKMWAFMSS 711
Query: 704 ------VKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATT 757
VK N+ ++ LTS AF+ ++ + ++ ++ C L IG + +
Sbjct: 712 RRQSVLVKSNEEGIQRVLTSDY-----AFLMESTTIEFVTQRN--CNLTQIGG--LIDSK 762
Query: 758 GYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAG 817
GYG+ S ++ I +A+LQ +G+ ++ W G E+ +S L + N+ G
Sbjct: 763 GYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGG 822
Query: 818 VFYMLLVAMGLALLVF 833
+F +++A GL L VF
Sbjct: 823 IF--IVLAAGLVLSVF 836
>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
Length = 1007
Score = 159 bits (401), Expect = 2e-38
Identities = 120/412 (29%), Positives = 205/412 (49%), Gaps = 43/412 (10%)
Query: 455 KGFCIDILKKLARVVKFSYDLYLVTNGKHGK-RVRGVWNGMIGEVYYKRADMAIGSLTIN 513
+GF ID+L L+ + F+Y++Y+ + K+G + G WNG++GE+ +KRAD+ I +LTI
Sbjct: 468 QGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTIT 527
Query: 514 EERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFM 573
+R +VDF+ +++ + V++ R+ TV A L P+ ++W + L +V + V++
Sbjct: 528 PDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVL-LVGLLVYL 586
Query: 574 FEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGT-TSKIMVLVW 632
+ +P R + + T+ S+W ++ E P T +++M+ W
Sbjct: 587 LNWLNP-------PRLQMGSMTSTTLYNSMWFVYGSFVQQGG--EVPYTTLATRMMMGAW 637
Query: 633 AFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNI 692
FA+I ++SYTANLAAF+ + ++ L D Q + P +GTV + + ++
Sbjct: 638 WLFALIVISSYTANLAAFLTITRIESSIQSLQDLS---KQTEIP---YGTVLDSAVYEHV 691
Query: 693 RSN-----YRD-MHTHMVKFNQRS---------VEDALTSLKMGKLDAFIYDAAVLNYMA 737
R RD M++ M + RS + + +K G AF++DAAVL Y+A
Sbjct: 692 RMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNY-AFVWDAAVLEYVA 750
Query: 738 GKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVW--LS 795
D C TIG+ A GYGIA+Q S ++ +L+ +G+ L+ W +
Sbjct: 751 INDPDCSFYTIGN--TVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKN 808
Query: 796 GIC---QNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLR 844
G C + + LDI + AGVF +L A G+ L F +W R
Sbjct: 809 GQCDLYSSVDTKQKGGALDIKSFAGVFCIL--AAGIVLSCFIAMLETWWNKR 858
>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
sapiens]
Length = 1009
Score = 149 bits (375), Expect = 2e-35
Identities = 110/406 (27%), Positives = 192/406 (47%), Gaps = 33/406 (8%)
Query: 455 KGFCIDILKKLARVVKFSYDLYLVTNGKHGKRVRGV-WNGMIGEVYYKRADMAIGSLTIN 513
KGF ID+L LA+ + F Y++Y +G++G ++ WNGMIGE+ KRAD+AI ++TI
Sbjct: 464 KGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITIT 523
Query: 514 EERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFM 573
ER +VDFS +++ + +++ + +S + P+ AVW + + VV + +F+
Sbjct: 524 PERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACI-AAAIPVVGVLIFV 582
Query: 574 FEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWA 633
V Q+ + + S + T+ ++W+++ F + +I++ W
Sbjct: 583 LNRIQAVR-AQSAAQPRPSA--SATLHSAIWIVYG-AFVQQGGESSVNSMAMRIVMGSWW 638
Query: 634 FFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQ--------RPQDQYPPFRFGTVPN 685
F +I +SYTANLAAF+ + + + D Q R Y FR
Sbjct: 639 LFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFR----AK 694
Query: 686 GSTERNIRSNYRDMHTHMVKFN-----QRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKD 740
G+ S + ++ + K S + + K G AF++D AV+ Y A D
Sbjct: 695 GTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNY-AFLWDVAVVEYAALTD 753
Query: 741 EGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWL--SGIC 798
+ C + IG+ ++ GYGIA+Q S ++ +L+ G+ L+ W G C
Sbjct: 754 DDCSVTVIGNS--ISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRC 811
Query: 799 ---QNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYW 841
+ + L + + AGVF +L + + LA LV A E ++W
Sbjct: 812 DLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALE--LWW 855
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 58.5 bits (140), Expect = 4e-08
Identities = 35/87 (40%), Positives = 40/87 (45%), Gaps = 8/87 (9%)
Query: 926 GRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGWGPPDGGRAALVRRAPQPPGRPPTPG 985
G PPP P P P PS P P PPP P P PP+ G AP PPG P P
Sbjct: 677 GPPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPGGPP---PAPPPPGLAPPPP 733
Query: 986 PPL-----SDVSRVSRRPAWEARWPVR 1007
P L S S+ R+PA E P++
Sbjct: 734 PGLFFGLGSSSSQCPRKPAIEPSCPMK 760
Score = 33.1 bits (74), Expect = 1.7
Identities = 21/57 (36%), Positives = 22/57 (38%), Gaps = 2/57 (3%)
Query: 942 PSPCLPTPDPPPEPSPTGWGPPDGGRAALVRRAPQPPGRPPTPGPPLSDVSRVSRRP 998
P P P PPP PS G P + P PP PP P PPL S P
Sbjct: 646 PPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPP--PPPPPPPLPPPSSAGPPP 700
Score = 33.1 bits (74), Expect = 1.7
Identities = 21/57 (36%), Positives = 22/57 (38%), Gaps = 10/57 (17%)
Query: 930 PPPSPCPTPRSGPSPCLPTPDPPPEPSPTGWGPPDGGRAALVRRAPQPPGRPPTPGP 986
PPP+ P P PS PP P P GPP P PP PP P P
Sbjct: 647 PPPASIPPPPPLPSGLGSLSPAPPMP-PVSAGPP---------LPPPPPPPPPLPPP 693
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,153,201
Number of Sequences: 37866
Number of extensions: 3216971
Number of successful extensions: 31152
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 280
Number of HSP's successfully gapped in prelim test: 1010
Number of HSP's that attempted gapping in prelim test: 17276
Number of HSP's gapped (non-prelim): 8719
length of query: 1233
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1119
effective length of database: 13,930,794
effective search space: 15588558486
effective search space used: 15588558486
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.