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Search of human proteins with 54607018
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|54607018 RYK receptor-like tyrosine kinase isoform 2 [Homo
sapiens]
(607 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|54607018 RYK receptor-like tyrosine kinase isoform 2 [Homo sa... 1213 0.0
gi|54607020 RYK receptor-like tyrosine kinase isoform 1 [Homo sa... 1208 0.0
gi|153946393 macrophage stimulating 1 receptor precursor [Homo s... 214 1e-55
gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens] 213 4e-55
gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens] 211 2e-54
gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens] 211 2e-54
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens] 202 9e-52
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens] 202 9e-52
gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens] 196 7e-50
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 192 1e-48
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 192 1e-48
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 192 1e-48
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 192 1e-48
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 189 5e-48
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 187 2e-47
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 187 2e-47
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 187 3e-47
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 187 3e-47
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 187 3e-47
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 187 3e-47
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 187 3e-47
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 187 3e-47
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 187 3e-47
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 186 5e-47
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 185 1e-46
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 182 1e-45
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 182 1e-45
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 179 7e-45
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 179 9e-45
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens] 177 2e-44
>gi|54607018 RYK receptor-like tyrosine kinase isoform 2 [Homo
sapiens]
Length = 607
Score = 1213 bits (3139), Expect = 0.0
Identities = 607/607 (100%), Positives = 607/607 (100%)
Query: 1 MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA 60
MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA
Sbjct: 1 MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA 60
Query: 61 GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE 120
GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE
Sbjct: 61 GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE 120
Query: 121 YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS 180
YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS
Sbjct: 121 YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS 180
Query: 181 KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI 240
KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI
Sbjct: 181 KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI 240
Query: 241 FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSYPT 300
FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSYPT
Sbjct: 241 FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSYPT 300
Query: 301 LRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQ 360
LRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQ
Sbjct: 301 LRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQ 360
Query: 361 AFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLK 420
AFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLK
Sbjct: 361 AFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLK 420
Query: 421 LFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVK 480
LFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVK
Sbjct: 421 LFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVK 480
Query: 481 ITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQ 540
ITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQ
Sbjct: 481 ITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQ 540
Query: 541 TPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFH 600
TPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFH
Sbjct: 541 TPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFH 600
Query: 601 AALGAYV 607
AALGAYV
Sbjct: 601 AALGAYV 607
>gi|54607020 RYK receptor-like tyrosine kinase isoform 1 [Homo
sapiens]
Length = 610
Score = 1208 bits (3125), Expect = 0.0
Identities = 607/610 (99%), Positives = 607/610 (99%), Gaps = 3/610 (0%)
Query: 1 MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA 60
MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA
Sbjct: 1 MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA 60
Query: 61 GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE 120
GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE
Sbjct: 61 GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE 120
Query: 121 YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS 180
YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS
Sbjct: 121 YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS 180
Query: 181 KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI 240
KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI
Sbjct: 181 KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI 240
Query: 241 FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITS--- 297
FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITS
Sbjct: 241 FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSLG 300
Query: 298 YPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNK 357
YPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNK
Sbjct: 301 YPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNK 360
Query: 358 EKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG 417
EKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG
Sbjct: 361 EKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG 420
Query: 418 NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTL 477
NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTL
Sbjct: 421 NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTL 480
Query: 478 QVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMT 537
QVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMT
Sbjct: 481 QVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMT 540
Query: 538 LGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT 597
LGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT
Sbjct: 541 LGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT 600
Query: 598 EFHAALGAYV 607
EFHAALGAYV
Sbjct: 601 EFHAALGAYV 610
>gi|153946393 macrophage stimulating 1 receptor precursor [Homo
sapiens]
Length = 1400
Score = 214 bits (546), Expect = 1e-55
Identities = 129/349 (36%), Positives = 193/349 (55%), Gaps = 23/349 (6%)
Query: 265 SASSSSQGLSQPSTQ---TTQYLRADTPNNATPITSYPTLR---IEKNDLRSVTLLEAKG 318
S S GL+ P+ +T + + +++ + P LR I+ DL S L E
Sbjct: 1013 SGSDYRSGLALPAIDGLDSTTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAE--- 1069
Query: 319 KVKDIAISRERITLKD--VLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVT 376
VKD+ I ER+ V+ +G FG ++HG ID+ Q +K++ QV
Sbjct: 1070 -VKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQ--NRIQCAIKSLSRITEMQQVE 1126
Query: 377 MMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQA 436
L E +RGL+H N+L + + + P V+LPYM G+L F+R + NP
Sbjct: 1127 AFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQ----RNPTV 1182
Query: 437 ISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYH 496
+DL+ +Q+A GM YLA ++ +H+DLAARNC++D++ VK+ D L+RD+ +Y+
Sbjct: 1183 ---KDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYY 1239
Query: 497 CLGDNENR--PVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAY 554
+ + + PV+WMALESL F++ SDVW+FGV LWEL+T G PY IDPF++ +
Sbjct: 1240 SVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHF 1299
Query: 555 LKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAAL 603
L G R+ QP CPD L+ VM CW DP RP F+ LV + + +AL
Sbjct: 1300 LAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSAL 1348
>gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]
Length = 999
Score = 213 bits (542), Expect = 4e-55
Identities = 115/283 (40%), Positives = 168/283 (59%), Gaps = 9/283 (3%)
Query: 315 EAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVK-DQASEI 373
E + K++D+ I R + L +L EG FG + G L E D K A VKT+K D +S+
Sbjct: 572 ELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQE-DGTSLKVA-VKTMKLDNSSQR 629
Query: 374 QVTMMLTESCKLRGLHHRNLLPITHVCIEEGE----KPMVILPYMNWGNLKLFLRQCKLV 429
++ L+E+ ++ H N++ + VCIE KPMVILP+M +G+L +L +L
Sbjct: 630 EIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRL- 688
Query: 430 EANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRD 489
P+ I Q L+ + IA GM YL+ R +H+DLAARNC++ D + V + D LS+
Sbjct: 689 -ETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKK 747
Query: 490 LFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPF 549
++ DY+ G PV+W+A+ESL + ++S SDVWAFGVT+WE+ T G TPY +
Sbjct: 748 IYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNH 807
Query: 550 EMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQL 592
EM YL G+R+ QP +C DEL+ +M CW DP +RP F L
Sbjct: 808 EMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVL 850
>gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens]
Length = 1390
Score = 211 bits (537), Expect = 2e-54
Identities = 117/331 (35%), Positives = 186/331 (56%), Gaps = 14/331 (4%)
Query: 265 SASSSSQGLSQPSTQTTQYLRADTPNNATPITSYPTLRIEKNDLRSVTLLEAKGKVKDIA 324
S + S + + P T + L + + ++P+ T+ I+ + L + + V I
Sbjct: 1016 SQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQN-TVHIDLSALNPELVQAVQHVV--IG 1072
Query: 325 ISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCK 384
S + +V+ G FG ++HG L+D + K+ VK++ +V+ LTE
Sbjct: 1073 PSSLIVHFNEVIGRGHFGCVYHGTLLD--NDGKKIHCAVKSLNRITDIGEVSQFLTEGII 1130
Query: 385 LRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVH 444
++ H N+L + +C+ P+V+LPYM G+L+ F+R E +NP +DL+
Sbjct: 1131 MKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRN----ETHNPTV---KDLIG 1183
Query: 445 MAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENR 504
+Q+A GM YLA ++ +H+DLAARNC++D+ VK+ D L+RD++ +Y+ + +
Sbjct: 1184 FGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGA 1243
Query: 505 --PVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIA 562
PV+WMALESL +F++ SDVW+FGV LWELMT G PY D++ F++ YL G R+
Sbjct: 1244 KLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLL 1303
Query: 563 QPINCPDELFAVMACCWALDPEERPKFQQLV 593
QP CPD L+ VM CW E RP F +LV
Sbjct: 1304 QPEYCPDPLYEVMLKCWHPKAEMRPSFSELV 1334
>gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens]
Length = 1408
Score = 211 bits (537), Expect = 2e-54
Identities = 117/331 (35%), Positives = 186/331 (56%), Gaps = 14/331 (4%)
Query: 265 SASSSSQGLSQPSTQTTQYLRADTPNNATPITSYPTLRIEKNDLRSVTLLEAKGKVKDIA 324
S + S + + P T + L + + ++P+ T+ I+ + L + + V I
Sbjct: 1034 SQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQN-TVHIDLSALNPELVQAVQHVV--IG 1090
Query: 325 ISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCK 384
S + +V+ G FG ++HG L+D + K+ VK++ +V+ LTE
Sbjct: 1091 PSSLIVHFNEVIGRGHFGCVYHGTLLD--NDGKKIHCAVKSLNRITDIGEVSQFLTEGII 1148
Query: 385 LRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVH 444
++ H N+L + +C+ P+V+LPYM G+L+ F+R E +NP +DL+
Sbjct: 1149 MKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRN----ETHNPTV---KDLIG 1201
Query: 445 MAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENR 504
+Q+A GM YLA ++ +H+DLAARNC++D+ VK+ D L+RD++ +Y+ + +
Sbjct: 1202 FGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGA 1261
Query: 505 --PVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIA 562
PV+WMALESL +F++ SDVW+FGV LWELMT G PY D++ F++ YL G R+
Sbjct: 1262 KLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLL 1321
Query: 563 QPINCPDELFAVMACCWALDPEERPKFQQLV 593
QP CPD L+ VM CW E RP F +LV
Sbjct: 1322 QPEYCPDPLYEVMLKCWHPKAEMRPSFSELV 1352
>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
Length = 885
Score = 202 bits (513), Expect = 9e-52
Identities = 111/295 (37%), Positives = 175/295 (59%), Gaps = 11/295 (3%)
Query: 315 EAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQ-ASEI 373
E K K++D+ + R ++ L L EG FG + G L +D + K A VKT+K +
Sbjct: 512 ELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQL--NQDDSILKVA-VKTMKIAICTRS 568
Query: 374 QVTMMLTESCKLRGLHHRNLLPITHVCIEEGEK-----PMVILPYMNWGNLKLFLRQCKL 428
++ L+E+ ++ H N++ + VC + E+ P+VILP+M G+L FL +L
Sbjct: 569 ELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRL 628
Query: 429 VEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSR 488
+ P + Q LV IA GM YL+ + IH+DLAARNC++++ + V + D LS+
Sbjct: 629 --GDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSK 686
Query: 489 DLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDP 548
++ DY+ G PV+W+A+ESL + ++S SDVW+FGVT+WE+ T GQTPY ++
Sbjct: 687 KIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVEN 746
Query: 549 FEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAAL 603
E+ YL+ G R+ QP +C D L+A+M+ CW L+P++RP F +L + L AL
Sbjct: 747 SEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKAL 801
>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
Length = 894
Score = 202 bits (513), Expect = 9e-52
Identities = 111/295 (37%), Positives = 175/295 (59%), Gaps = 11/295 (3%)
Query: 315 EAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQ-ASEI 373
E K K++D+ + R ++ L L EG FG + G L +D + K A VKT+K +
Sbjct: 521 ELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQL--NQDDSILKVA-VKTMKIAICTRS 577
Query: 374 QVTMMLTESCKLRGLHHRNLLPITHVCIEEGEK-----PMVILPYMNWGNLKLFLRQCKL 428
++ L+E+ ++ H N++ + VC + E+ P+VILP+M G+L FL +L
Sbjct: 578 ELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRL 637
Query: 429 VEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSR 488
+ P + Q LV IA GM YL+ + IH+DLAARNC++++ + V + D LS+
Sbjct: 638 --GDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSK 695
Query: 489 DLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDP 548
++ DY+ G PV+W+A+ESL + ++S SDVW+FGVT+WE+ T GQTPY ++
Sbjct: 696 KIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVEN 755
Query: 549 FEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAAL 603
E+ YL+ G R+ QP +C D L+A+M+ CW L+P++RP F +L + L AL
Sbjct: 756 SEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKAL 810
>gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens]
Length = 890
Score = 196 bits (497), Expect = 7e-50
Identities = 107/280 (38%), Positives = 160/280 (57%), Gaps = 8/280 (2%)
Query: 315 EAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQ 374
E K K++D+ I ++ TL +L +G FG + L E D + K A D +
Sbjct: 503 ELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE-DGSFVKVAVKMLKADIIASSD 561
Query: 375 VTMMLTESCKLRGLHHRNLLPITHVCIEEGEK-----PMVILPYMNWGNLKLFLRQCKLV 429
+ L E+ ++ H ++ + V + K PMVILP+M G+L FL ++
Sbjct: 562 IEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIG 621
Query: 430 EANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRD 489
E NP + Q L+ + IACGM YL+ R IH+DLAARNC++ + + V + D LSR
Sbjct: 622 E--NPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRK 679
Query: 490 LFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPF 549
++ DY+ G PV+W+ALESL +N ++ SDVWAFGVT+WE+MT GQTPY I+
Sbjct: 680 IYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENA 739
Query: 550 EMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKF 589
E+ YL G R+ QP C ++++ +M CW+ DP++RP F
Sbjct: 740 EIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSF 779
Score = 33.5 bits (75), Expect = 0.58
Identities = 27/65 (41%), Positives = 29/65 (44%), Gaps = 8/65 (12%)
Query: 7 LGRPGRSCLPGARGLRAPPPPPLLLLLALLP--LLPAPGAAAAPAPRPPELQSASAGPSV 64
+GRPG LP PPPP L LLLA L LLP AA P + S G V
Sbjct: 7 MGRPGLPPLP------LPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV 60
Query: 65 SLYLS 69
L S
Sbjct: 61 KLNCS 65
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 192 bits (487), Expect = 1e-48
Identities = 117/400 (29%), Positives = 210/400 (52%), Gaps = 18/400 (4%)
Query: 213 TIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQG 272
T+ + + P T Y+ + + C FL++ ++ + ++ MK + +
Sbjct: 266 TVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHK 325
Query: 273 LSQPSTQTTQYLRADTPNNATPITSYPTLRIEKNDLRSVTLLEAKGKVK-----DIAISR 327
L++ S + + ++A+ + +R + +L + + + R
Sbjct: 326 LAK-SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPR 384
Query: 328 ERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKL 385
+R+ L L EG FG++ I +D+ PN+ + VK +K A+E ++ +++E +
Sbjct: 385 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 444
Query: 386 RGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ--------CKLVEANNPQA 436
+ + H+N++ + C ++G VI+ Y + GNL+ +L+ C N +
Sbjct: 445 KMIGKHKNIINLLGACTQDGPL-YVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 503
Query: 437 ISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYH 496
+S +DLV A Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+
Sbjct: 504 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 563
Query: 497 CLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLK 556
N PV+WMA E+L + ++ SDVW+FGV LWE+ TLG +PY + E+ LK
Sbjct: 564 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 623
Query: 557 DGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 596
+G+R+ +P NC +EL+ +M CW P +RP F+QLV+ L
Sbjct: 624 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 663
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 192 bits (487), Expect = 1e-48
Identities = 117/400 (29%), Positives = 210/400 (52%), Gaps = 18/400 (4%)
Query: 213 TIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQG 272
T+ + + P T Y+ + + C FL++ ++ + ++ MK + +
Sbjct: 268 TVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHK 327
Query: 273 LSQPSTQTTQYLRADTPNNATPITSYPTLRIEKNDLRSVTLLEAKGKVK-----DIAISR 327
L++ S + + ++A+ + +R + +L + + + R
Sbjct: 328 LAK-SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPR 386
Query: 328 ERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKL 385
+R+ L L EG FG++ I +D+ PN+ + VK +K A+E ++ +++E +
Sbjct: 387 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 446
Query: 386 RGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ--------CKLVEANNPQA 436
+ + H+N++ + C ++G VI+ Y + GNL+ +L+ C N +
Sbjct: 447 KMIGKHKNIINLLGACTQDGPL-YVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 505
Query: 437 ISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYH 496
+S +DLV A Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+
Sbjct: 506 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 565
Query: 497 CLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLK 556
N PV+WMA E+L + ++ SDVW+FGV LWE+ TLG +PY + E+ LK
Sbjct: 566 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 625
Query: 557 DGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 596
+G+R+ +P NC +EL+ +M CW P +RP F+QLV+ L
Sbjct: 626 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 665
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 192 bits (487), Expect = 1e-48
Identities = 117/400 (29%), Positives = 210/400 (52%), Gaps = 18/400 (4%)
Query: 213 TIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQG 272
T+ + + P T Y+ + + C FL++ ++ + ++ MK + +
Sbjct: 355 TVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHK 414
Query: 273 LSQPSTQTTQYLRADTPNNATPITSYPTLRIEKNDLRSVTLLEAKGKVK-----DIAISR 327
L++ S + + ++A+ + +R + +L + + + R
Sbjct: 415 LAK-SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPR 473
Query: 328 ERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKL 385
+R+ L L EG FG++ I +D+ PN+ + VK +K A+E ++ +++E +
Sbjct: 474 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 533
Query: 386 RGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ--------CKLVEANNPQA 436
+ + H+N++ + C ++G VI+ Y + GNL+ +L+ C N +
Sbjct: 534 KMIGKHKNIINLLGACTQDGPL-YVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 592
Query: 437 ISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYH 496
+S +DLV A Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+
Sbjct: 593 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 652
Query: 497 CLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLK 556
N PV+WMA E+L + ++ SDVW+FGV LWE+ TLG +PY + E+ LK
Sbjct: 653 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 712
Query: 557 DGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 596
+G+R+ +P NC +EL+ +M CW P +RP F+QLV+ L
Sbjct: 713 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 752
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 192 bits (487), Expect = 1e-48
Identities = 117/400 (29%), Positives = 210/400 (52%), Gaps = 18/400 (4%)
Query: 213 TIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQG 272
T+ + + P T Y+ + + C FL++ ++ + ++ MK + +
Sbjct: 357 TVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHK 416
Query: 273 LSQPSTQTTQYLRADTPNNATPITSYPTLRIEKNDLRSVTLLEAKGKVK-----DIAISR 327
L++ S + + ++A+ + +R + +L + + + R
Sbjct: 417 LAK-SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPR 475
Query: 328 ERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKL 385
+R+ L L EG FG++ I +D+ PN+ + VK +K A+E ++ +++E +
Sbjct: 476 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 535
Query: 386 RGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ--------CKLVEANNPQA 436
+ + H+N++ + C ++G VI+ Y + GNL+ +L+ C N +
Sbjct: 536 KMIGKHKNIINLLGACTQDGPL-YVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 594
Query: 437 ISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYH 496
+S +DLV A Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+
Sbjct: 595 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 654
Query: 497 CLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLK 556
N PV+WMA E+L + ++ SDVW+FGV LWE+ TLG +PY + E+ LK
Sbjct: 655 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 714
Query: 557 DGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 596
+G+R+ +P NC +EL+ +M CW P +RP F+QLV+ L
Sbjct: 715 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 754
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 189 bits (481), Expect = 5e-48
Identities = 120/383 (31%), Positives = 204/383 (53%), Gaps = 18/383 (4%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQ--PSTQTTQYLRAD 287
Y+ + + C +FL+A ++ + L MK S+ + L++ P + +
Sbjct: 260 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSS 319
Query: 288 TPNNATPITSYPTLRIEKND---LRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRI 344
+ N+ TP+ T D L V+ E K R+++TL L EG FG++
Sbjct: 320 SMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK-WEFPRDKLTLGKPLGEGCFGQV 378
Query: 345 F--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHRNLLPITHVCI 401
+ ID+ P + VK +KD A+E ++ +++E ++ + H+N++ + C
Sbjct: 379 VMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT 438
Query: 402 EEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLVHMAIQIACGM 453
++G VI+ Y + GNL+ +LR + + + ++ +DLV Q+A GM
Sbjct: 439 QDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGM 497
Query: 454 SYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALES 513
YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+ N PV+WMA E+
Sbjct: 498 EYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEA 557
Query: 514 LVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFA 573
L + ++ SDVW+FGV +WE+ TLG +PY I E+ LK+G+R+ +P NC +EL+
Sbjct: 558 LFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYM 617
Query: 574 VMACCWALDPEERPKFQQLVQCL 596
+M CW P +RP F+QLV+ L
Sbjct: 618 MMRDCWHAVPSQRPTFKQLVEDL 640
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 187 bits (476), Expect = 2e-47
Identities = 98/276 (35%), Positives = 163/276 (59%), Gaps = 3/276 (1%)
Query: 325 ISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCK 384
+SRE+ITL L +G+FG ++ G D E + VKTV + AS + L E+
Sbjct: 1006 VSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASV 1065
Query: 385 LRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNP--QAISQQDL 442
++G +++ + V + +G+ +V++ M G+LK +LR + NNP + Q++
Sbjct: 1066 MKGFTCHHVVRLLGV-VSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEM 1124
Query: 443 VHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNE 502
+ MA +IA GM+YL ++ +H+DLAARNC++ VKI D ++RD++ DY+ G
Sbjct: 1125 IQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKG 1184
Query: 503 NRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIA 562
PVRWMA ESL + F+++SD+W+FGV LWE+ +L + PY + ++ ++ DG +
Sbjct: 1185 LLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLD 1244
Query: 563 QPINCPDELFAVMACCWALDPEERPKFQQLVQCLTE 598
QP NCP+ + +M CW +P+ RP F ++V L +
Sbjct: 1245 QPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD 1280
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 187 bits (476), Expect = 2e-47
Identities = 98/276 (35%), Positives = 163/276 (59%), Gaps = 3/276 (1%)
Query: 325 ISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCK 384
+SRE+ITL L +G+FG ++ G D E + VKTV + AS + L E+
Sbjct: 1018 VSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASV 1077
Query: 385 LRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNP--QAISQQDL 442
++G +++ + V + +G+ +V++ M G+LK +LR + NNP + Q++
Sbjct: 1078 MKGFTCHHVVRLLGV-VSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEM 1136
Query: 443 VHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNE 502
+ MA +IA GM+YL ++ +H+DLAARNC++ VKI D ++RD++ DY+ G
Sbjct: 1137 IQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKG 1196
Query: 503 NRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIA 562
PVRWMA ESL + F+++SD+W+FGV LWE+ +L + PY + ++ ++ DG +
Sbjct: 1197 LLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLD 1256
Query: 563 QPINCPDELFAVMACCWALDPEERPKFQQLVQCLTE 598
QP NCP+ + +M CW +P+ RP F ++V L +
Sbjct: 1257 QPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD 1292
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 187 bits (474), Expect = 3e-47
Identities = 120/385 (31%), Positives = 203/385 (52%), Gaps = 20/385 (5%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYL----R 285
Y+ + + C +FL+A ++ + L MK S+ + L++ Q
Sbjct: 287 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 346
Query: 286 ADTPNNATPITSYPTLRIEKND---LRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFG 342
+ + N+ TP+ T D L V+ E K R+++TL L EG FG
Sbjct: 347 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK-WEFPRDKLTLGKPLGEGCFG 405
Query: 343 RIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHRNLLPITHV 399
++ + ID+ P + VK +KD A+E ++ +++E ++ + H+N++ +
Sbjct: 406 QVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGA 465
Query: 400 CIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLVHMAIQIAC 451
C ++G VI+ Y + GNL+ +LR + + + ++ +DLV Q+A
Sbjct: 466 CTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLAR 524
Query: 452 GMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMAL 511
GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+ N PV+WMA
Sbjct: 525 GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAP 584
Query: 512 ESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDEL 571
E+L + ++ SDVW+FGV +WE+ TLG +PY I E+ LK+G+R+ +P NC +EL
Sbjct: 585 EALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNEL 644
Query: 572 FAVMACCWALDPEERPKFQQLVQCL 596
+ +M CW P +RP F+QLV+ L
Sbjct: 645 YMMMRDCWHAVPSQRPTFKQLVEDL 669
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 187 bits (474), Expect = 3e-47
Identities = 120/385 (31%), Positives = 203/385 (52%), Gaps = 20/385 (5%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYL----R 285
Y+ + + C +FL+A ++ + L MK S+ + L++ Q
Sbjct: 376 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 435
Query: 286 ADTPNNATPITSYPTLRIEKND---LRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFG 342
+ + N+ TP+ T D L V+ E K R+++TL L EG FG
Sbjct: 436 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK-WEFPRDKLTLGKPLGEGCFG 494
Query: 343 RIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHRNLLPITHV 399
++ + ID+ P + VK +KD A+E ++ +++E ++ + H+N++ +
Sbjct: 495 QVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGA 554
Query: 400 CIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLVHMAIQIAC 451
C ++G VI+ Y + GNL+ +LR + + + ++ +DLV Q+A
Sbjct: 555 CTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLAR 613
Query: 452 GMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMAL 511
GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+ N PV+WMA
Sbjct: 614 GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAP 673
Query: 512 ESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDEL 571
E+L + ++ SDVW+FGV +WE+ TLG +PY I E+ LK+G+R+ +P NC +EL
Sbjct: 674 EALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNEL 733
Query: 572 FAVMACCWALDPEERPKFQQLVQCL 596
+ +M CW P +RP F+QLV+ L
Sbjct: 734 YMMMRDCWHAVPSQRPTFKQLVEDL 758
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 187 bits (474), Expect = 3e-47
Identities = 120/385 (31%), Positives = 203/385 (52%), Gaps = 20/385 (5%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYL----R 285
Y+ + + C +FL+A ++ + L MK S+ + L++ Q
Sbjct: 260 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 319
Query: 286 ADTPNNATPITSYPTLRIEKND---LRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFG 342
+ + N+ TP+ T D L V+ E K R+++TL L EG FG
Sbjct: 320 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK-WEFPRDKLTLGKPLGEGCFG 378
Query: 343 RIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHRNLLPITHV 399
++ + ID+ P + VK +KD A+E ++ +++E ++ + H+N++ +
Sbjct: 379 QVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGA 438
Query: 400 CIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLVHMAIQIAC 451
C ++G VI+ Y + GNL+ +LR + + + ++ +DLV Q+A
Sbjct: 439 CTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLAR 497
Query: 452 GMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMAL 511
GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+ N PV+WMA
Sbjct: 498 GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAP 557
Query: 512 ESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDEL 571
E+L + ++ SDVW+FGV +WE+ TLG +PY I E+ LK+G+R+ +P NC +EL
Sbjct: 558 EALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNEL 617
Query: 572 FAVMACCWALDPEERPKFQQLVQCL 596
+ +M CW P +RP F+QLV+ L
Sbjct: 618 YMMMRDCWHAVPSQRPTFKQLVEDL 642
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 187 bits (474), Expect = 3e-47
Identities = 120/385 (31%), Positives = 203/385 (52%), Gaps = 20/385 (5%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYL----R 285
Y+ + + C +FL+A ++ + L MK S+ + L++ Q
Sbjct: 286 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 345
Query: 286 ADTPNNATPITSYPTLRIEKND---LRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFG 342
+ + N+ TP+ T D L V+ E K R+++TL L EG FG
Sbjct: 346 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK-WEFPRDKLTLGKPLGEGCFG 404
Query: 343 RIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHRNLLPITHV 399
++ + ID+ P + VK +KD A+E ++ +++E ++ + H+N++ +
Sbjct: 405 QVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGA 464
Query: 400 CIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLVHMAIQIAC 451
C ++G VI+ Y + GNL+ +LR + + + ++ +DLV Q+A
Sbjct: 465 CTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLAR 523
Query: 452 GMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMAL 511
GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+ N PV+WMA
Sbjct: 524 GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAP 583
Query: 512 ESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDEL 571
E+L + ++ SDVW+FGV +WE+ TLG +PY I E+ LK+G+R+ +P NC +EL
Sbjct: 584 EALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNEL 643
Query: 572 FAVMACCWALDPEERPKFQQLVQCL 596
+ +M CW P +RP F+QLV+ L
Sbjct: 644 YMMMRDCWHAVPSQRPTFKQLVEDL 668
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 187 bits (474), Expect = 3e-47
Identities = 120/385 (31%), Positives = 203/385 (52%), Gaps = 20/385 (5%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYL----R 285
Y+ + + C +FL+A ++ + L MK S+ + L++ Q
Sbjct: 263 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 322
Query: 286 ADTPNNATPITSYPTLRIEKND---LRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFG 342
+ + N+ TP+ T D L V+ E K R+++TL L EG FG
Sbjct: 323 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK-WEFPRDKLTLGKPLGEGCFG 381
Query: 343 RIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHRNLLPITHV 399
++ + ID+ P + VK +KD A+E ++ +++E ++ + H+N++ +
Sbjct: 382 QVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGA 441
Query: 400 CIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLVHMAIQIAC 451
C ++G VI+ Y + GNL+ +LR + + + ++ +DLV Q+A
Sbjct: 442 CTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLAR 500
Query: 452 GMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMAL 511
GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+ N PV+WMA
Sbjct: 501 GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAP 560
Query: 512 ESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDEL 571
E+L + ++ SDVW+FGV +WE+ TLG +PY I E+ LK+G+R+ +P NC +EL
Sbjct: 561 EALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNEL 620
Query: 572 FAVMACCWALDPEERPKFQQLVQCL 596
+ +M CW P +RP F+QLV+ L
Sbjct: 621 YMMMRDCWHAVPSQRPTFKQLVEDL 645
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 187 bits (474), Expect = 3e-47
Identities = 120/385 (31%), Positives = 203/385 (52%), Gaps = 20/385 (5%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYL----R 285
Y+ + + C +FL+A ++ + L MK S+ + L++ Q
Sbjct: 375 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 434
Query: 286 ADTPNNATPITSYPTLRIEKND---LRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFG 342
+ + N+ TP+ T D L V+ E K R+++TL L EG FG
Sbjct: 435 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK-WEFPRDKLTLGKPLGEGCFG 493
Query: 343 RIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHRNLLPITHV 399
++ + ID+ P + VK +KD A+E ++ +++E ++ + H+N++ +
Sbjct: 494 QVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGA 553
Query: 400 CIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLVHMAIQIAC 451
C ++G VI+ Y + GNL+ +LR + + + ++ +DLV Q+A
Sbjct: 554 CTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLAR 612
Query: 452 GMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMAL 511
GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+ N PV+WMA
Sbjct: 613 GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAP 672
Query: 512 ESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDEL 571
E+L + ++ SDVW+FGV +WE+ TLG +PY I E+ LK+G+R+ +P NC +EL
Sbjct: 673 EALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNEL 732
Query: 572 FAVMACCWALDPEERPKFQQLVQCL 596
+ +M CW P +RP F+QLV+ L
Sbjct: 733 YMMMRDCWHAVPSQRPTFKQLVEDL 757
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 187 bits (474), Expect = 3e-47
Identities = 120/385 (31%), Positives = 203/385 (52%), Gaps = 20/385 (5%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYL----R 285
Y+ + + C +FL+A ++ + L MK S+ + L++ Q
Sbjct: 376 YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAES 435
Query: 286 ADTPNNATPITSYPTLRIEKND---LRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFG 342
+ + N+ TP+ T D L V+ E K R+++TL L EG FG
Sbjct: 436 SSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK-WEFPRDKLTLGKPLGEGCFG 494
Query: 343 RIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGL-HHRNLLPITHV 399
++ + ID+ P + VK +KD A+E ++ +++E ++ + H+N++ +
Sbjct: 495 QVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGA 554
Query: 400 CIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQAISQQDLVHMAIQIAC 451
C ++G VI+ Y + GNL+ +LR + + + ++ +DLV Q+A
Sbjct: 555 CTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLAR 613
Query: 452 GMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMAL 511
GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY+ N PV+WMA
Sbjct: 614 GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAP 673
Query: 512 ESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDEL 571
E+L + ++ SDVW+FGV +WE+ TLG +PY I E+ LK+G+R+ +P NC +EL
Sbjct: 674 EALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNEL 733
Query: 572 FAVMACCWALDPEERPKFQQLVQCL 596
+ +M CW P +RP F+QLV+ L
Sbjct: 734 YMMMRDCWHAVPSQRPTFKQLVEDL 758
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 186 bits (472), Expect = 5e-47
Identities = 95/276 (34%), Positives = 161/276 (58%), Gaps = 3/276 (1%)
Query: 325 ISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCK 384
++RE+IT+ L +G+FG ++ G+ E + +KTV + AS + L E+
Sbjct: 994 VAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASV 1053
Query: 385 LRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAI--SQQDL 442
++ + +++ + V + +G+ +VI+ M G+LK +LR + NNP S +
Sbjct: 1054 MKEFNCHHVVRLLGV-VSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKM 1112
Query: 443 VHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNE 502
+ MA +IA GM+YL + +H+DLAARNC++ + VKI D ++RD++ DY+ G
Sbjct: 1113 IQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKG 1172
Query: 503 NRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIA 562
PVRWM+ ESL + F++ SDVW+FGV LWE+ TL + PY + ++ ++ +G +
Sbjct: 1173 LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLD 1232
Query: 563 QPINCPDELFAVMACCWALDPEERPKFQQLVQCLTE 598
+P NCPD LF +M CW +P+ RP F +++ + E
Sbjct: 1233 KPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKE 1268
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 185 bits (469), Expect = 1e-46
Identities = 123/367 (33%), Positives = 196/367 (53%), Gaps = 35/367 (9%)
Query: 251 HLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSYPTLRI------E 304
H+ +K +E++ S + T L+ +NA+ ++ P +RI E
Sbjct: 284 HIQWLKHVEVNGS--------KVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGE 335
Query: 305 KNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAF 362
L +V+ LE K +SR R+TL L EG FG++ I ID+ K
Sbjct: 336 GPTLANVSELELPADPK-WELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVA 394
Query: 363 VKTVKDQASEIQVTMMLTESCKLRGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKL 421
VK +KD A++ ++ +++E ++ + H+N++ + C + G V++ Y GNL+
Sbjct: 395 VKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL-YVLVEYAAKGNLRE 453
Query: 422 FLRQ------------CKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAAR 469
FLR CK E + ++ +DLV A Q+A GM YLA ++ IH+DLAAR
Sbjct: 454 FLRARRPPGLDYSFDTCKPPE----EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAAR 509
Query: 470 NCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFG 529
N ++ + +KI D L+RD+ +DY+ N PV+WMA E+L + ++ SDVW+FG
Sbjct: 510 NVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 569
Query: 530 VTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKF 589
V LWE+ TLG +PY I E+ LK+G+R+ +P NC +L+ +M CW P +RP F
Sbjct: 570 VLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTF 629
Query: 590 QQLVQCL 596
+QLV+ L
Sbjct: 630 KQLVEDL 636
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 182 bits (461), Expect = 1e-45
Identities = 121/355 (34%), Positives = 190/355 (53%), Gaps = 31/355 (8%)
Query: 267 SSSSQGLSQPSTQTTQYL----RADTPNNATPITSYPTLRI------EKNDLRSVTLLEA 316
S +GL P+ + +NA+ ++ P +RI E L +V+ LE
Sbjct: 402 SPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELEL 461
Query: 317 KGKVKDIAISRERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQ 374
K +SR R+TL L EG FG++ I ID+ K VK +KD A++
Sbjct: 462 PADPK-WELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD 520
Query: 375 VTMMLTESCKLRGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ-------- 425
++ +++E ++ + H+N++ + C + G V++ Y GNL+ FLR
Sbjct: 521 LSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL-YVLVEYAAKGNLREFLRARRPPGLDY 579
Query: 426 ----CKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKI 481
CK E + ++ +DLV A Q+A GM YLA ++ IH+DLAARN ++ + +KI
Sbjct: 580 SFDTCKPPE----EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKI 635
Query: 482 TDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQT 541
D L+RD+ +DY+ N PV+WMA E+L + ++ SDVW+FGV LWE+ TLG +
Sbjct: 636 ADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGS 695
Query: 542 PYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 596
PY I E+ LK+G+R+ +P NC +L+ +M CW P +RP F+QLV+ L
Sbjct: 696 PYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 750
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 182 bits (461), Expect = 1e-45
Identities = 121/355 (34%), Positives = 190/355 (53%), Gaps = 31/355 (8%)
Query: 267 SSSSQGLSQPSTQTTQYL----RADTPNNATPITSYPTLRI------EKNDLRSVTLLEA 316
S +GL P+ + +NA+ ++ P +RI E L +V+ LE
Sbjct: 400 SPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELEL 459
Query: 317 KGKVKDIAISRERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQ 374
K +SR R+TL L EG FG++ I ID+ K VK +KD A++
Sbjct: 460 PADPK-WELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD 518
Query: 375 VTMMLTESCKLRGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQ-------- 425
++ +++E ++ + H+N++ + C + G V++ Y GNL+ FLR
Sbjct: 519 LSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL-YVLVEYAAKGNLREFLRARRPPGLDY 577
Query: 426 ----CKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKI 481
CK E + ++ +DLV A Q+A GM YLA ++ IH+DLAARN ++ + +KI
Sbjct: 578 SFDTCKPPE----EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKI 633
Query: 482 TDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQT 541
D L+RD+ +DY+ N PV+WMA E+L + ++ SDVW+FGV LWE+ TLG +
Sbjct: 634 ADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGS 693
Query: 542 PYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 596
PY I E+ LK+G+R+ +P NC +L+ +M CW P +RP F+QLV+ L
Sbjct: 694 PYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 748
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 179 bits (454), Expect = 7e-45
Identities = 100/281 (35%), Positives = 166/281 (59%), Gaps = 12/281 (4%)
Query: 327 RERITLKDVLQEGTFGRIF--HGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCK 384
R+++TL L EG FG++ + ID+ P + VK +KD A+E ++ +++E
Sbjct: 362 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 421
Query: 385 LRGL-HHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKL--------VEANNPQ 435
++ + H+N++ + C ++G VI+ Y + GNL+ +LR + + +
Sbjct: 422 MKMIGKHKNIINLLGACTQDGPL-YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEE 480
Query: 436 AISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDY 495
++ +DLV Q+A GM YLA ++ IH+DLAARN ++ + +KI D L+RD+ +DY
Sbjct: 481 QMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDY 540
Query: 496 HCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYL 555
+ N PV+WMA E+L + ++ SDVW+FGV +WE+ TLG +PY I E+ L
Sbjct: 541 YKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL 600
Query: 556 KDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL 596
K+G+R+ +P NC +EL+ +M CW P +RP F+QLV+ L
Sbjct: 601 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 641
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
c precursor [Homo sapiens]
Length = 822
Score = 179 bits (453), Expect = 9e-45
Identities = 115/389 (29%), Positives = 186/389 (47%), Gaps = 15/389 (3%)
Query: 230 YISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTP 289
Y V + V F + ++L +L L + + S S+ + P + +
Sbjct: 434 YAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSS 493
Query: 290 NNATP------ITSYPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGR 343
+ P +T P IE +T + K I R I LK L EG FG+
Sbjct: 494 SEGGPDAVIIGMTKIPV--IENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGK 551
Query: 344 IFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEE 403
+F + + VKT+KD AS+ E+ L L H +++ VC+E
Sbjct: 552 VFLAECYNLCPEQDKILVAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVE- 609
Query: 404 GEKPMVILPYMNWGNLKLFLRQ-----CKLVEANNPQAISQQDLVHMAIQIACGMSYLAR 458
G+ +++ YM G+L FLR + E N P ++Q ++H+A QIA GM YLA
Sbjct: 610 GDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLAS 669
Query: 459 REVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNE 518
+ +H+DLA RNC++ + L VKI D +SRD++ DY+ +G + P+RWM ES++ +
Sbjct: 670 QHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK 729
Query: 519 FSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACC 578
F++ SDVW+ GV LWE+ T G+ P+ + E+ + G + +P CP E++ +M C
Sbjct: 730 FTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGC 789
Query: 579 WALDPEERPKFQQLVQCLTEFHAALGAYV 607
W +P R + + L A Y+
Sbjct: 790 WQREPHMRKNIKGIHTLLQNLAKASPVYL 818
>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
Length = 2347
Score = 177 bits (449), Expect = 2e-44
Identities = 100/282 (35%), Positives = 158/282 (56%), Gaps = 8/282 (2%)
Query: 324 AISRERITLKDVLQEGTFGRIFHGILIDEKDPNK-EKQAFVKTVKDQASEIQVTMMLTES 382
A RE++TL+ +L G FG ++ G +D E + VKT+K +++ + L E+
Sbjct: 1939 AFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEA 1998
Query: 383 CKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDL 442
+ +H N+L VC+ E +IL M G+L +LR+ ++ P ++ DL
Sbjct: 1999 HLMSKFNHPNILKQLGVCLLN-EPQYIILELMEGGDLLTYLRKARMATFYGP-LLTLVDL 2056
Query: 443 VHMAIQIACGMSYLARREVIHKDLAARNCVID-----DTLQVKITDNALSRDLFPMDYHC 497
V + + I+ G YL R IH+DLAARNC++ VKI D L+RD++ DY+
Sbjct: 2057 VDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYR 2116
Query: 498 LGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKD 557
PVRWMA ESL++ F++ SDVW+FG+ +WE++TLG PY ++ Y++
Sbjct: 2117 KRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQT 2176
Query: 558 GYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEF 599
G R+ P NCPD+L+ +M CWA +P++RP F ++ L F
Sbjct: 2177 GGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLF 2218
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,189,996
Number of Sequences: 37866
Number of extensions: 1122594
Number of successful extensions: 10386
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 447
Number of HSP's successfully gapped in prelim test: 451
Number of HSP's that attempted gapping in prelim test: 8007
Number of HSP's gapped (non-prelim): 2026
length of query: 607
length of database: 18,247,518
effective HSP length: 108
effective length of query: 499
effective length of database: 14,157,990
effective search space: 7064837010
effective search space used: 7064837010
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.