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Search of human proteins with 52485606
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|52485606 formin-like 2 [Homo sapiens]
(1092 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|52485606 formin-like 2 [Homo sapiens] 2166 0.0
gi|119120874 formin-like 3 isoform 1 [Homo sapiens] 1419 0.0
gi|119120861 formin-like 3 isoform 2 [Homo sapiens] 1346 0.0
gi|33356148 formin-like 1 [Homo sapiens] 1185 0.0
gi|21071077 dishevelled-associated activator of morphogenesis 1 ... 340 6e-93
gi|40548415 dishevelled associated activator of morphogenesis 2 ... 331 3e-90
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens] 272 1e-72
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens] 264 4e-70
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens] 263 5e-70
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens] 248 2e-65
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 238 3e-62
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 238 3e-62
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens] 237 4e-62
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens] 237 4e-62
gi|157168329 formin 1 [Homo sapiens] 179 2e-44
gi|145309324 FH2 domain containing 1 [Homo sapiens] 168 2e-41
gi|160707881 formin 2 [Homo sapiens] 155 2e-37
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 135 3e-31
gi|58331242 formin homology 2 domain containing 3 [Homo sapiens] 115 3e-25
gi|118572599 formin homology 2 domain containing 1 [Homo sapiens] 108 2e-23
gi|56549694 enabled homolog isoform a [Homo sapiens] 92 3e-18
gi|39930375 enabled homolog isoform b [Homo sapiens] 92 3e-18
gi|153792074 proline rich 12 [Homo sapiens] 91 6e-18
gi|126090663 zinc finger homeodomain 4 [Homo sapiens] 90 1e-17
gi|210032580 SET domain containing 1B [Homo sapiens] 89 3e-17
gi|14249316 hypothetical protein LOC84800 [Homo sapiens] 87 9e-17
gi|11386183 WAS protein family, member 2 [Homo sapiens] 80 1e-14
gi|56118221 amyloid beta (A4) precursor protein-binding, family ... 79 3e-14
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap... 77 7e-14
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo... 77 1e-13
>gi|52485606 formin-like 2 [Homo sapiens]
Length = 1092
Score = 2166 bits (5613), Expect = 0.0
Identities = 1092/1092 (100%), Positives = 1092/1092 (100%)
Query: 1 MGNAGSMDSQQTDFRAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKK 60
MGNAGSMDSQQTDFRAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKK
Sbjct: 1 MGNAGSMDSQQTDFRAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKK 60
Query: 61 WELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIG 120
WELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIG
Sbjct: 61 WELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIG 120
Query: 121 WVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTVESSVDKSKPWSRSIEDLHRGSN 180
WVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTVESSVDKSKPWSRSIEDLHRGSN
Sbjct: 121 WVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTVESSVDKSKPWSRSIEDLHRGSN 180
Query: 181 LPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNM 240
LPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNM
Sbjct: 181 LPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNM 240
Query: 241 VMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRF 300
VMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRF
Sbjct: 241 VMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRF 300
Query: 301 EKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTE 360
EKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTE
Sbjct: 301 EKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTE 360
Query: 361 SDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKI 420
SDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKI
Sbjct: 361 SDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKI 420
Query: 421 VELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGT 480
VELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGT
Sbjct: 421 VELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGT 480
Query: 481 IKIQKKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTP 540
IKIQKKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTP
Sbjct: 481 IKIQKKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTP 540
Query: 541 ETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGT 600
ETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGT
Sbjct: 541 ETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGT 600
Query: 601 SSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDE 660
SSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDE
Sbjct: 601 SSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDE 660
Query: 661 FEEIFKTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAI 720
FEEIFKTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAI
Sbjct: 661 FEEIFKTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAI 720
Query: 721 HVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQ 780
HVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQ
Sbjct: 721 HVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQ 780
Query: 781 KMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAV 840
KMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAV
Sbjct: 781 KMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAV 840
Query: 841 YGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVL 900
YGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVL
Sbjct: 841 YGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVL 900
Query: 901 LDVKELQRGMDLTKREYTMHDHNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGE 960
LDVKELQRGMDLTKREYTMHDHNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGE
Sbjct: 901 LDVKELQRGMDLTKREYTMHDHNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGE 960
Query: 961 NPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHK 1020
NPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHK
Sbjct: 961 NPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHK 1020
Query: 1021 SKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITDLRNQPYRRADAVRRSVRRRFDDQ 1080
SKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITDLRNQPYRRADAVRRSVRRRFDDQ
Sbjct: 1021 SKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITDLRNQPYRRADAVRRSVRRRFDDQ 1080
Query: 1081 NLRSVNGAEITM 1092
NLRSVNGAEITM
Sbjct: 1081 NLRSVNGAEITM 1092
>gi|119120874 formin-like 3 isoform 1 [Homo sapiens]
Length = 1027
Score = 1419 bits (3674), Expect = 0.0
Identities = 732/1043 (70%), Positives = 857/1043 (82%), Gaps = 61/1043 (5%)
Query: 20 PLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTY 79
P K+PMPEP ELEERFA+VL++MNLPPDKARLLRQYDNEKKW+LICDQERFQVKNPPHTY
Sbjct: 23 PGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTY 82
Query: 80 IQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEY 139
IQKL+ +LDP+VTRKKFRRRVQEST+VLRELEISLRTNHIGWVREFLN+ENKGLDVLV+Y
Sbjct: 83 IQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDY 142
Query: 140 LSFAQYAVTFDFESVESTVESSVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALR 199
LSFAQ +V FDFE +ES + + DK + WSRSIEDL S L +P NS++RS R S LR
Sbjct: 143 LSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLR 202
Query: 200 YNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKN 259
Y+TLP RR LKNSRLVS+KDDVHVCI+CLRAIMNYQYGFN+VMSHPHAVNEIALSLNNKN
Sbjct: 203 YSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKN 262
Query: 260 PRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVA 319
PRTKALVLELLAAVCLVRGGHEIIL+AFDNFKEVC E RFEKLME+FRNED+NIDFMVA
Sbjct: 263 PRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVA 322
Query: 320 SMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVG 379
MQFINIVVHSVEDMNFRVHLQYEFTKLGL+E+L K +HTES+KLQVQIQAYLDNVFDVG
Sbjct: 323 CMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVG 382
Query: 380 ALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVRE 439
LLEDAETKN ALE+VEELEE++SHL+EKL D ENE M ++ ELEKQL+QR KEL+ ++E
Sbjct: 383 GLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKE 442
Query: 440 IYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVVAS 499
Y++ + QVHTLR+++KEKEEA QR+ LE + LE
Sbjct: 443 TYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLE----------------------- 479
Query: 500 GTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPP 559
S+ SE +A VGP A S +PP L + PE V P+PPPP PP
Sbjct: 480 ---SVDSEALA--RVGP---AELSEGMPPSDLDLLAPAPPPEEVL------PLPPPPAPP 525
Query: 560 PPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKP 619
PPPPPP P PP APPLPG ++P+VV GL+A++IKKP
Sbjct: 526 LPPPPPPLPDKCPP--------------------APPLPG-AAPSVVLTVGLSAIRIKKP 564
Query: 620 IKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSS 679
IKTKFR+PVFNW ALKPNQI+GTVF+E+DDE+ILEDL++D+FEE+FKTKAQGPA+DL S
Sbjct: 565 IKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICS 624
Query: 680 KQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRF 739
K K QK ++KVTLLEANRAKNLAITLRKAG++A+EIC+AIH FDL+TLPVDFVECLMRF
Sbjct: 625 KNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRF 684
Query: 740 LPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLT 799
LPTE EVK+LR YERER+PLE L+ EDRFM+ FSK+ERL Q+M MAF+GNF +++QMLT
Sbjct: 685 LPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLT 744
Query: 800 PQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDR 859
PQL+AIIAAS S+KSSQKLK++LEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDR
Sbjct: 745 PQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDR 804
Query: 860 KQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTM 919
K TLLH+I+ VKEKY ++ F++ELH+VEKAAAVSLENVLLDVKEL RGM+L +RE ++
Sbjct: 805 KMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSI 864
Query: 920 HDHNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVK 979
HD N++L+ F+ NEGKL KLQ DAK A++A++ VV+YFGE+PKTTPPSVFFPVFVRF++
Sbjct: 865 HD-NSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIR 923
Query: 980 AYKQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAELRRRQVKD 1039
+YK+AE+ENE RKKQE+ + EK L QEA ++ D K+PS ++K QQQELIAELRRRQ K+
Sbjct: 924 SYKEAEQENEARKKQEEVMREKQLAQEA--KKLDAKTPSQRNKWQQQELIAELRRRQAKE 981
Query: 1040 NRHVYEGKDGAIEDIITDLRNQP 1062
+R VYEGKDG IEDIIT L QP
Sbjct: 982 HRPVYEGKDGTIEDIITGLHCQP 1004
>gi|119120861 formin-like 3 isoform 2 [Homo sapiens]
Length = 976
Score = 1346 bits (3483), Expect = 0.0
Identities = 705/1043 (67%), Positives = 821/1043 (78%), Gaps = 112/1043 (10%)
Query: 20 PLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTY 79
P K+PMPEP ELEERFA+VL++MNLPPDKARLLRQYDNEKKW+LICDQERFQVKNPPHTY
Sbjct: 23 PGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTY 82
Query: 80 IQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEY 139
IQKL+ +LDP+VTRKKFRRRVQEST+VLRELEISLRTNHIGWVREFLN+ENKGLDVLV+Y
Sbjct: 83 IQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDY 142
Query: 140 LSFAQYAVTFDFESVESTVESSVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALR 199
LSFAQ +V
Sbjct: 143 LSFAQCSVM--------------------------------------------------- 151
Query: 200 YNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKN 259
Y+TLP RR LKNSRLVS+KDDVHVCI+CLRAIMNYQYGFN+VMSHPHAVNEIALSLNNKN
Sbjct: 152 YSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKN 211
Query: 260 PRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVA 319
PRTKALVLELLAAVCLVRGGHEIIL+AFDNFKEVC E RFEKLME+FRNED+NIDFMVA
Sbjct: 212 PRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVA 271
Query: 320 SMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVG 379
MQFINIVVHSVEDMNFRVHLQYEFTKLGL+E+L K +HTES+KLQVQIQAYLDNVFDVG
Sbjct: 272 CMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVG 331
Query: 380 ALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVRE 439
LLEDAETKN ALE+VEELEE++SHL+EKL D ENE M ++ ELEKQL+QR KEL+ ++E
Sbjct: 332 GLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKE 391
Query: 440 IYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVVAS 499
Y++ + QVHTLR+++KEKEEA QR+ LE + LE
Sbjct: 392 TYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLE----------------------- 428
Query: 500 GTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPP 559
S+ SE +A VGP A S +PP L P PPP
Sbjct: 429 ---SVDSEALA--RVGP---AELSEGMPPSDLDL---------------LAPAPPPEEVL 465
Query: 560 PPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKP 619
P PPPP PP PPPP PPL P APPLPG ++P+VV GL+A++IKKP
Sbjct: 466 PLPPPPAPPLPPPP-----------PPLPDKCPPAPPLPG-AAPSVVLTVGLSAIRIKKP 513
Query: 620 IKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSS 679
IKTKFR+PVFNW ALKPNQI+GTVF+E+DDE+ILEDL++D+FEE+FKTKAQGPA+DL S
Sbjct: 514 IKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICS 573
Query: 680 KQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRF 739
K K QK ++KVTLLEANRAKNLAITLRKAG++A+EIC+AIH FDL+TLPVDFVECLMRF
Sbjct: 574 KNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRF 633
Query: 740 LPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLT 799
LPTE EVK+LR YERER+PLE L+ EDRFM+ FSK+ERL Q+M MAF+GNF +++QMLT
Sbjct: 634 LPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLT 693
Query: 800 PQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDR 859
PQL+AIIAAS S+KSSQKLK++LEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDR
Sbjct: 694 PQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDR 753
Query: 860 KQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTM 919
K TLLH+I+ VKEKY ++ F++ELH+VEKAAAVSLENVLLDVKEL RGM+L +RE ++
Sbjct: 754 KMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSI 813
Query: 920 HDHNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVK 979
HD N++L+ F+ NEGKL KLQ DAK A++A++ VV+YFGE+PKTTPPSVFFPVFVRF++
Sbjct: 814 HD-NSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIR 872
Query: 980 AYKQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAELRRRQVKD 1039
+YK+AE+ENE RKKQE+ + EK L QEA ++ D K+PS ++K QQQELIAELRRRQ K+
Sbjct: 873 SYKEAEQENEARKKQEEVMREKQLAQEA--KKLDAKTPSQRNKWQQQELIAELRRRQAKE 930
Query: 1040 NRHVYEGKDGAIEDIITDLRNQP 1062
+R VYEGKDG IEDIIT L QP
Sbjct: 931 HRPVYEGKDGTIEDIITGLHCQP 953
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 1185 bits (3066), Expect = 0.0
Identities = 642/1102 (58%), Positives = 791/1102 (71%), Gaps = 46/1102 (4%)
Query: 1 MGNAGSMDSQQTDFRA----HNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYD 56
MGNA Q A P K PMP GELEERF LN MNLPPDK +LL QYD
Sbjct: 1 MGNAAGSAEQPAGPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYD 60
Query: 57 NEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKK----------FRRRVQESTQV 106
NEKKWELICDQERFQVKNPP YIQKLK Y+D +K F+RRVQESTQV
Sbjct: 61 NEKKWELICDQERFQVKNPPAAYIQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQESTQV 120
Query: 107 LRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTVESSVDKSK 166
LRELE SLRTNHIGWV+EFLNEEN+GLDVL+EYL+FAQ +VT+D ES ++ +S +K+K
Sbjct: 121 LRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNS-EKNK 179
Query: 167 PWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIM 226
P +S+EDL +G PS V S RH ++ SR+ L+NSR+VS+KDDVHVCIM
Sbjct: 180 PLEQSVEDLSKGP--PSSVPKS-----RHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIM 232
Query: 227 CLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSA 286
CLRAIMNYQ GF++VM+HP VNEIALSLNNKNPRTKALVLELLAAVCLVRGGH+IIL+A
Sbjct: 233 CLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAA 292
Query: 287 FDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTK 346
FDNFKEVCGE+ RFEKLME+FRNED+NIDFMVA MQFINIVVHSVE+MNFRV LQYEFT
Sbjct: 293 FDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTH 352
Query: 347 LGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLS 406
LGLD YL++L+ TESDKLQVQIQAYLDN+FDVGALLED ETKNA LE +EEL+E ++ L+
Sbjct: 353 LGLDLYLERLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQVALLT 412
Query: 407 EKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEE--AIQR 464
E+L+D ENE+M+KI ELEKQL Q KEL+ +RE + ++ + R EK A R
Sbjct: 413 ERLRDAENESMAKIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTR 472
Query: 465 QSTLEKKIHELEKQGTIKIQKKGDGD---IAILPVVASGTLSMGSEVVAGNSVG---PTM 518
S LE K+ ELE++G I+I + G GD I ILPV A T S G G G P +
Sbjct: 473 PSALELKVEELEEKGLIRILR-GPGDAVSIEILPV-AVATPSGGDAPTPGVPTGSPSPDL 530
Query: 519 GAASS---GPLPPPPPPLPPSSDTPETVQNGPV-TPPMPPPPPPPPPPPPP----PPPPP 570
A+ G PPPPPPLP E + P PP+P P PPP PP P PPPPP
Sbjct: 531 APAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPP 590
Query: 571 PPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFN 630
PPP PG P PP PP P PP G VK KKPI+TKFRMP+ N
Sbjct: 591 PPPPPGTDGPVPPPPPPPPPPPGGPP-DALGRRDSELGPG---VKAKKPIQTKFRMPLLN 646
Query: 631 WVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKIPQKGSNK 690
WVALKP+QI GTVF E++DE++L++L++ +FEE FKTK+QGP++DLS+ K K QK +K
Sbjct: 647 WVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSK 706
Query: 691 VTLLEANRAKNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLR 750
TL+EANRAKNLAITLRK A+ IC+AI +DL+ L +DF+E LMRFLPTE E ++
Sbjct: 707 ATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLIT 766
Query: 751 LYERERKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASV 810
+ERE++P+E LS+EDRFM+ FS+I RL ++MT + F+GNF ++ Q+L PQL+AIIAAS+
Sbjct: 767 RFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASM 826
Query: 811 SIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNV 870
SIKSS KL++ILEI+LA GNYMNSSKRGA YGF+LQSLD LL+ KSTDRKQTLLHY+ V
Sbjct: 827 SIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKV 886
Query: 871 VKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFI 930
+ EKY Q++ F+++LH+++KA +VSL++VL DV+ LQRG++LT+RE+ D +LKEF+
Sbjct: 887 IAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFL 946
Query: 931 LNNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENEL 990
N + KL D+K AQ+AF+ VV+YFGENPKTT P +FF +F RF+KAYK+AE+E E
Sbjct: 947 RANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQ 1006
Query: 991 RKKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGA 1050
KK E A E + E PKSP K++R Q +LI+EL+RRQ K+ +DGA
Sbjct: 1007 WKK-EAAAQEAGADTPGKGEPPAPKSPP-KARRPQMDLISELKRRQQKEPLIYESDRDGA 1064
Query: 1051 IEDIITDLRNQPYRRADAVRRS 1072
IEDIIT ++ P+ R S
Sbjct: 1065 IEDIITVIKTVPFTARTGKRTS 1086
>gi|21071077 dishevelled-associated activator of morphogenesis 1 [Homo
sapiens]
Length = 1078
Score = 340 bits (871), Expect = 6e-93
Identities = 264/912 (28%), Positives = 443/912 (48%), Gaps = 110/912 (12%)
Query: 209 LKNSRLVSKKDDVHVCIM-CLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVL 267
LK + + +H ++ C++A+MN G V++H ++N IA SL+ +N +TK VL
Sbjct: 165 LKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVL 224
Query: 268 ELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNED----NNIDFMVASMQF 323
E+L AVCLV GGH+ +L A ++++ E+ RF+ L+ + + A M F
Sbjct: 225 EILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSF 284
Query: 324 INIVVH---SVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAY--LDNV--- 375
IN V+ VE ++FR+HL+YEF LG+ +DKL+ E+ L + + L N
Sbjct: 285 INAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDEL 344
Query: 376 ----------FDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVE--- 422
D + + E L E +S L LQ + + +
Sbjct: 345 EFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLL 404
Query: 423 ----LEKQLMQRNKELDVVREIYKDANTQVHTLRKMV--------KEKEEAIQRQ-STLE 469
+++ ++Q +K D ++ N + + +R +V KE+ E ++++ + L+
Sbjct: 405 LDRIIQQIVIQNDKGQDPDSTPLENFNIK-NVVRMLVNENEVKQWKEQAEKMRKEHNELQ 463
Query: 470 KKIHELEKQGTIKIQKKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTMG---------- 519
+K+ + E++ K Q+K + ++ + + E V +
Sbjct: 464 QKLEKKERECDAKTQEKEE----MMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELS 519
Query: 520 -AASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPP---PPPPPPPPPPPPPPLP 575
A +P P P P P +V G + PP PPPP P PPPPPP PP PPP P
Sbjct: 520 RRAVCASIPGGPSPGAPGGPFPSSVP-GSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPP 578
Query: 576 GPAAETVPAPPLAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALK 635
GP PPL + P PG GLA K P T + FNW L
Sbjct: 579 GP-----------PPLGAIMPPPGAP-------MGLALKKKSIPQPTN-ALKSFNWSKLP 619
Query: 636 PNQINGTVFNEIDDERILEDLNVDEFEEIFKT-KAQGPAIDLSSSKQK----IPQKGSNK 690
N++ GTV+ EIDD ++ + L++++ E F + Q S+SKQK I S+K
Sbjct: 620 ENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFFVNSNSKQKEADAIDDTLSSK 679
Query: 691 -----VTLLEANRAKNLAITLRKAGKTADEICKAIHVFD-LKTLPVDFVECLMRFLPTEN 744
+++++ RA+N I L + + DEI +AI D + LP D +E L++F+P ++
Sbjct: 680 LKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKS 739
Query: 745 EVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHA 804
++ +L E + L+ ++ DRF+ + S+I Q++ + F FAE + + P++ A
Sbjct: 740 DIDLL---EEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEA 796
Query: 805 IIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKST-DRKQTL 863
I + S + S LK++LE++LA GNYMN +RG YGFK+ SL+ + DTKS+ D+ TL
Sbjct: 797 IRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSIDKNITL 856
Query: 864 LHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHN 923
LHY+ +V+ KY V EL + +AA V++ + ++ L+ G+ + E
Sbjct: 857 LHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKSQ 916
Query: 924 ---------TLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVF 974
+++ +FI ++D A+D F VK+FGE P FF +F
Sbjct: 917 PPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGIF 976
Query: 975 VRFVKAYKQAEEENE-LRKKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQE------ 1027
+F++A +A++ENE +RKK+E+ +E + L EQ++ + K+K +E
Sbjct: 977 DQFLQAVSEAKQENENMRKKKEEEERRARMEAQ-LKEQRERERKMRKAKENSEESGEFDD 1035
Query: 1028 LIAELRRRQVKD 1039
L++ LR +V D
Sbjct: 1036 LVSALRSGEVFD 1047
Score = 53.1 bits (126), Expect = 1e-06
Identities = 36/156 (23%), Positives = 74/156 (47%), Gaps = 13/156 (8%)
Query: 12 TDFRAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQ 71
++F + LPMP EL+ F+ +++ ++L + EKKW++ C +++ Q
Sbjct: 34 SNFALQTMEPALPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKDQ 93
Query: 72 VKNP-----PHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFL 126
+N P YI +L + +E ++ + L+ +LRT + +V F+
Sbjct: 94 EENKGATSWPEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFI 153
Query: 127 NEENKGLDVLVEYLSFAQYAVTFDFESVESTVESSV 162
+ + GL ++ +L T D+E+ ES + +S+
Sbjct: 154 DLD--GLSCILNFLK------TMDYETSESRIHTSL 181
>gi|40548415 dishevelled associated activator of morphogenesis 2 [Homo
sapiens]
Length = 1067
Score = 331 bits (848), Expect = 3e-90
Identities = 253/902 (28%), Positives = 452/902 (50%), Gaps = 114/902 (12%)
Query: 225 IMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIIL 284
I C++A+MN G V++ P A++ IA SL +N +TK VLE+L AVCLV GGH+ +L
Sbjct: 178 IGCIKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVL 237
Query: 285 SAFDNFKEVCGEKQRFEKLMEHFRNE----DNNIDFMVASMQFINIVVHS---VEDMNFR 337
A +++ E+ RF+ L+ + ++ A M FIN V+++ +++ FR
Sbjct: 238 QAMLHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFR 297
Query: 338 VHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAY----------LDNVFDVGALLEDAET 387
+HL+YEF LG+ +DKL+ E+ L + + L FD+ + D ++
Sbjct: 298 LHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHI--DTKS 355
Query: 388 KNAALERVEELEE---------NISHLSEKLQDTENEAMSKIVELEKQLMQR---NKELD 435
+ E + + + ++ H ++ N + +L +++Q+ E
Sbjct: 356 ASQMFELIHKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERG 415
Query: 436 VVREIYKDANTQVHTLRKMV--------------KEKEEAIQRQSTLEKKIHE-----LE 476
V ++ N V + M+ K ++E ++ S LE+K E LE
Sbjct: 416 VDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLE 475
Query: 477 KQGTIKIQKKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPS 536
K+ ++ K +A +E+VA + S+GP+ PPPP
Sbjct: 476 KEEMMRTLNKMKDKLARESQELRQARGQVAELVA------QLSELSTGPVSSPPPP---- 525
Query: 537 SDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPP-LPSAP 595
P T+ + T +PPPPPP P PPPPPPP P GP P PP APP L
Sbjct: 526 -GGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGP-----PTPPGAPPCLGMGL 579
Query: 596 PLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILED 655
PLP P S ++ K+ + + FNWV L ++ GTV+NEIDD ++
Sbjct: 580 PLPQDPYP-----SSDVPLRKKRVPQPSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRI 634
Query: 656 LNVDEFEEIFKT-----KAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAG 710
L++++FE++F K G D+ + +K+ + +++++ RA+N I L K
Sbjct: 635 LDLEDFEKMFSAYQRHQKELGSTEDIYLASRKVKE-----LSVIDGRRAQNCIILLSKLK 689
Query: 711 KTADEICKAIHVFD-LKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFM 769
+ +EI +AI D + L D +E L++F+P ++++ +L ++ E +E ++ DRF+
Sbjct: 690 LSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHE---IERMARADRFL 746
Query: 770 MQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALG 829
+ S+I+ Q++ + F F E + P++ AI+ AS + S++L+++LE+ILA+G
Sbjct: 747 YEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIG 806
Query: 830 NYMNSSKRGAVYGFKLQSLDLLLDTKST-DRKQTLLHYISNVVKEKYHQVSLFYNELHYV 888
N+MN +RG YGF++ SL+ + DTKS+ DR +LLHY+ ++++ + + +EL ++
Sbjct: 807 NFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHL 866
Query: 889 EKAAAVSLENVLLDVKELQRGMDLTK-REYTMHDHN-------TLLKEFILNNEGKLKKL 940
+AA V+L + +V L+RG+ + EY ++ +FI + +L
Sbjct: 867 PEAAKVNLAELEKEVGNLRRGLRAVEVLEYQRRQVREPSDKFVPVMSDFITVSSFSFSEL 926
Query: 941 QDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENEL--RKKQEQAL 998
+D A+D F + +FGE+ P FF +F F++A+ +A ++ E R+K+E+
Sbjct: 927 EDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEE-- 984
Query: 999 MEKLLEQEALMEQQDPKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITDL 1058
E+ EA++++Q + + +RQ++ L A + EG G +D+++ L
Sbjct: 985 -ERRARMEAMLKEQRER---ERWQRQRKVLAA---------GSSLEEG--GEFDDLVSAL 1029
Query: 1059 RN 1060
R+
Sbjct: 1030 RS 1031
>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
Length = 1193
Score = 272 bits (696), Expect = 1e-72
Identities = 219/853 (25%), Positives = 404/853 (47%), Gaps = 100/853 (11%)
Query: 218 KDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVR 277
K + H I CL+A+MN QYG +MS +++ +A +++ ++P V++LL+AVC+V
Sbjct: 240 KKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIV- 298
Query: 278 GGHEIILSAFDNFKEVCGEKQRFEK---LMEHFRNEDNNIDFMVASMQFINIVVHSVEDM 334
G E IL GE+++ ++ ++E R+ N++ VA MQ IN +V S +D+
Sbjct: 299 -GEESILEEVLEALTSAGEEKKIDRFFCIVEGLRH--NSVQLQVACMQLINALVTSPDDL 355
Query: 335 NFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAY----LDNVFDVGALLEDAETKNA 390
+FR+H++ EF + GL E L LK ++D L +Q++ + +++F++ LED +
Sbjct: 356 DFRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAE-- 413
Query: 391 ALERVEELEENISHLSEKLQDTENEA-----MSKIVELEKQLMQRNKELDVVRE------ 439
++E + + + +++T E + ++ + R + ++ E
Sbjct: 414 ----LDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIV 469
Query: 440 IYKDANTQVHTLRKMVK--------------EKEEAIQRQSTLEKKIHE--LEKQGTIKI 483
+++D T RK + + EE ++ S L KK + + Q T
Sbjct: 470 LHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFEEKASELYKKFEKEFTDHQETQAE 529
Query: 484 QKKGDGDIAILPVVASGTLSMGSEVVAGNSVG--PTMGAASSGPLPPPPPPLPPSSDTPE 541
+K + I L S + A ++ P+ + PPPPPLP
Sbjct: 530 LQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLP------- 582
Query: 542 TVQNGPVTPPMPPPPPPPPPP----PPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPL 597
+G PP PPPPPPPP P P P PPPPPL + +PPLP P
Sbjct: 583 ---SGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQN------SPPLPILP-- 631
Query: 598 PGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLN 657
+K KK K + M NW+ ++P+++ F +E E+++
Sbjct: 632 --------------FGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVD 677
Query: 658 -VDEFEEIFKTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEI 716
+ + E F + + + ++K +K ++ L++ A+NL+I L +EI
Sbjct: 678 LLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEI 737
Query: 717 CKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIE 776
I D L ++ L++ LP + ++ L ++ E NL + ++F++ S ++
Sbjct: 738 RMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSE---YSNLCEPEQFVVVMSNVK 794
Query: 777 RLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSK 836
RL +++ + F F E + + P + A+ A IK S+ K+LE++L +GNYMN+
Sbjct: 795 RLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGS 854
Query: 837 RGA-VYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVS 895
R A +GF L SL L DTKS D+K TLLH++ + +EKY + F ++L ++KA+ VS
Sbjct: 855 RNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVS 914
Query: 896 LENVLLDVKELQRGMDLTKREY-------TMHD-HNTLLKEFILNNEGKLKKLQDDAKIA 947
+E + +++++ R + ++E +HD T + F+++ + + + L +
Sbjct: 915 VETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENM 974
Query: 948 QDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQ-----ALMEKL 1002
+ + ++ Y+ + K F F + QA +EN +++ E+ + ++L
Sbjct: 975 EKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKEL 1034
Query: 1003 LEQEALMEQQDPK 1015
E+E L QQ K
Sbjct: 1035 AERERLERQQKKK 1047
>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
Length = 1101
Score = 264 bits (674), Expect = 4e-70
Identities = 242/920 (26%), Positives = 411/920 (44%), Gaps = 100/920 (10%)
Query: 210 KNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLEL 269
K + KK+ + I CL+A MN ++G ++ ++ +A +++ K P ++++
Sbjct: 220 KQQENIDKKNQYKL-IQCLKAFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKI 278
Query: 270 LAAVCLVRGGHEIILSAFDNFKEVCGEK---QRFEKLMEHFRNEDNNIDFMVASMQFINI 326
L+A+C+V G E IL E+ +RF ++E N++ + VA MQFIN
Sbjct: 279 LSAICIV--GEENILDKLLGAITTAAERNNRERFSPIVEGLENQEA-LQLQVACMQFINA 335
Query: 327 VVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAE 386
+V S +++FR+HL+ EF + GL L LK E+D+L +Q++ + +N D L E +
Sbjct: 336 LVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKED--DLTELSH 393
Query: 387 TKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYK---D 443
N ++++ E L L+DT E + L+ L+ RN + + + YK +
Sbjct: 394 RLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSI-LQHFLLIRN-DYYIRPQYYKIIEE 451
Query: 444 ANTQV----------------------HTLRKMVKEK--EEAIQRQSTLEKKIHE---LE 476
+Q+ H + V + EE+ Q+ + KK E
Sbjct: 452 CVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTAR 511
Query: 477 KQGTIKIQKKGDG----DIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPP-P 531
++ ++QK+ + + I + + S + G P + GP PPPP P
Sbjct: 512 QEAQAELQKRDEKIKELEAEIQQLRTQAQVLSSSSGIPGPPAAPPLPGV--GPPPPPPAP 569
Query: 532 PLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPL 591
PLP + P+PPPPPP P PPPPPPP L G PP PPL
Sbjct: 570 PLPGGA-------------PLPPPPPPLPGMMGIPPPPPPPLLFG-------GPPPPPPL 609
Query: 592 PSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDER 651
PP PG S +K KK K + M NW ++P +++ F R
Sbjct: 610 GGVPPPPGISLNLPY------GMKQKKMYKPEVSMKRINWSKIEPTELSENCF----WLR 659
Query: 652 ILEDL--NVDEFEEI---FKT--KAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAI 704
+ ED N D F ++ F T K Q A L K +K ++ +L+ A+NL+I
Sbjct: 660 VKEDKFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSI 719
Query: 705 TLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSD 764
L ++I I + L ++ L++ LP E K+L + ++L +
Sbjct: 720 FLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLP---EQKILNELAELKNEYDDLCE 776
Query: 765 EDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEI 824
++F + S ++ L +++ + F F E I + P + A+ A +K S+ ++LE+
Sbjct: 777 PEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLEL 836
Query: 825 ILALGNYMNSSKRGA-VYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYN 883
+L +GNYMNS R A GFK+ L + DTKS D+K TLLH+I+++ +EKY + F
Sbjct: 837 VLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPE 896
Query: 884 ELHYVEKAAAVSLENVLLDVKELQRGM-----DLTKREYTMHDHNTLLKE---FILNNEG 935
EL +VE A+ VS + + ++ +++ + D+ K + H+ +++ F
Sbjct: 897 ELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTARE 956
Query: 936 KLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQE 995
+ +KL ++++ +YF + KT FF F + +A EN R++ E
Sbjct: 957 QYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREME 1016
Query: 996 QALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDII 1055
+ L +E + + K K K+Q ++ E V DN A D
Sbjct: 1017 EKTRRAKLAKE---KAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRR 1073
Query: 1056 TDLRNQPYRRADAVRRSVRR 1075
+ P R + RS R
Sbjct: 1074 KRIPRNPDNRRVPLERSRSR 1093
>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
Length = 1096
Score = 263 bits (673), Expect = 5e-70
Identities = 235/885 (26%), Positives = 402/885 (45%), Gaps = 100/885 (11%)
Query: 210 KNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLEL 269
K + KK+ + I CL+A MN ++G ++ ++ +A +++ K P ++++
Sbjct: 220 KQQENIDKKNQYKL-IQCLKAFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKI 278
Query: 270 LAAVCLVRGGHEIILSAFDNFKEVCGEK---QRFEKLMEHFRNEDNNIDFMVASMQFINI 326
L+A+C+V G E IL E+ +RF ++E N++ + VA MQFIN
Sbjct: 279 LSAICIV--GEENILDKLLGAITTAAERNNRERFSPIVEGLENQEA-LQLQVACMQFINA 335
Query: 327 VVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAE 386
+V S +++FR+HL+ EF + GL L LK E+D+L +Q++ + +N D L E +
Sbjct: 336 LVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKED--DLTELSH 393
Query: 387 TKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYK---D 443
N ++++ E L L+DT E + L+ L+ RN + + + YK +
Sbjct: 394 RLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSI-LQHFLLIRN-DYYIRPQYYKIIEE 451
Query: 444 ANTQV----------------------HTLRKMVKEK--EEAIQRQSTLEKKIHE---LE 476
+Q+ H + V + EE+ Q+ + KK E
Sbjct: 452 CVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTAR 511
Query: 477 KQGTIKIQKKGDG----DIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPP-P 531
++ ++QK+ + + I + + S + G P + GP PPPP P
Sbjct: 512 QEAQAELQKRDEKIKELEAEIQQLRTQAQVLSSSSGIPGPPAAPPLPGV--GPPPPPPAP 569
Query: 532 PLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPL 591
PLP + P+PPPPPP P PPPPPPP L G PP PPL
Sbjct: 570 PLPGGA-------------PLPPPPPPLPGMMGIPPPPPPPLLFG-------GPPPPPPL 609
Query: 592 PSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDER 651
PP PG S +K KK K + M NW ++P +++ F R
Sbjct: 610 GGVPPPPGISLNLPY------GMKQKKMYKPEVSMKRINWSKIEPTELSENCF----WLR 659
Query: 652 ILEDL--NVDEFEEI---FKT--KAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAI 704
+ ED N D F ++ F T K Q A L K +K ++ +L+ A+NL+I
Sbjct: 660 VKEDKFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSI 719
Query: 705 TLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSD 764
L ++I I + L ++ L++ LP E K+L + ++L +
Sbjct: 720 FLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLP---EQKILNELAELKNEYDDLCE 776
Query: 765 EDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEI 824
++F + S ++ L +++ + F F E I + P + A+ A +K S+ ++LE+
Sbjct: 777 PEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLEL 836
Query: 825 ILALGNYMNSSKRGA-VYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYN 883
+L +GNYMNS R A GFK+ L + DTKS D+K TLLH+I+++ +EKY + F
Sbjct: 837 VLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPE 896
Query: 884 ELHYVEKAAAVSLENVLLDVKELQRGM-----DLTKREYTMHDHNTLLKE---FILNNEG 935
EL +VE A+ VS + + ++ +++ + D+ K + H+ +++ F
Sbjct: 897 ELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTARE 956
Query: 936 KLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQE 995
+ +KL ++++ +YF + KT FF F + +A EN R++ E
Sbjct: 957 QYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREME 1016
Query: 996 QALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAELRRRQVKDN 1040
+ L +E + + K K K+Q ++ E V DN
Sbjct: 1017 EKTRRAKLAKE---KAEQEKLERQKKKKQLIDINKEGDETGVMDN 1058
>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
Length = 849
Score = 248 bits (634), Expect = 2e-65
Identities = 208/829 (25%), Positives = 389/829 (46%), Gaps = 100/829 (12%)
Query: 242 MSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFE 301
MS +++ +A +++ ++P V++LL+AVC+V G E IL GE+++ +
Sbjct: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIV--GEESILEEVLEALTSAGEEKKID 58
Query: 302 K---LMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKH 358
+ ++E R+ N++ VA MQ IN +V S +D++FR+H++ EF + GL E L LK
Sbjct: 59 RFFCIVEGLRH--NSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKC 116
Query: 359 TESDKLQVQIQAY----LDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTEN 414
++D L +Q++ + +++F++ LED + ++E + + + +++T
Sbjct: 117 IKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAE------LDEAYDVYNMVWSTVKETRA 170
Query: 415 EA-----MSKIVELEKQLMQRNKELDVVRE------IYKDANTQVHTLRKMVK------- 456
E + ++ + R + ++ E +++D T RK +
Sbjct: 171 EGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFV 230
Query: 457 -------EKEEAIQRQSTLEKKIHE--LEKQGTIKIQKKGDGDIAILPVVASGTLSMGSE 507
+ EE ++ S L KK + + Q T +K + I L S
Sbjct: 231 DICIDQAKLEEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGA 290
Query: 508 VVAGNSVG--PTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPP--- 562
+ A ++ P+ + PPPPPLP +G PP PPPPPPPP P
Sbjct: 291 LPADCNIPLPPSKEGGTGHSALPPPPPLP----------SGGGVPPPPPPPPPPPLPGMR 340
Query: 563 -PPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKPIK 621
P P PPPPPL + +PPLP P +K KK K
Sbjct: 341 MPFSGPVPPPPPLGFLGGQN------SPPLPILP----------------FGLKPKKEFK 378
Query: 622 TKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLN-VDEFEEIFKTKAQGPAIDLSSSK 680
+ M NW+ ++P+++ F +E E+++ + + E F + + + +
Sbjct: 379 PEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEE 438
Query: 681 QKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFL 740
+K +K ++ L++ A+NL+I L +EI I D L ++ L++ L
Sbjct: 439 KKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHL 498
Query: 741 PTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTP 800
P + ++ L ++ E NL + ++F++ S ++RL +++ + F F E + + P
Sbjct: 499 PDQEQLNSLSQFKSE---YSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKP 555
Query: 801 QLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGA-VYGFKLQSLDLLLDTKSTDR 859
+ A+ A IK S+ K+LE++L +GNYMN+ R A +GF L SL L DTKS D+
Sbjct: 556 DIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQ 615
Query: 860 KQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREY-- 917
K TLLH++ + +EKY + F ++L ++KA+ VS+E + +++++ R + ++E
Sbjct: 616 KTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELET 675
Query: 918 -----TMHD-HNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFF 971
+HD T + F+++ + + + L + + + ++ Y+ + K F
Sbjct: 676 FPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFL 735
Query: 972 PVFVRFVKAYKQAEEENELRKKQEQ-----ALMEKLLEQEALMEQQDPK 1015
F + QA +EN +++ E+ + ++L E+E L QQ K
Sbjct: 736 TDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKK 784
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 238 bits (606), Expect = 3e-62
Identities = 235/987 (23%), Positives = 409/987 (41%), Gaps = 199/987 (20%)
Query: 222 HVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLV---RG 278
H I CL+A MN ++G ++ + + +++ P +LL+A+C++
Sbjct: 206 HEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPED 265
Query: 279 GHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRV 338
+E +L A E+ E +RF+ L++ ++ I V +Q IN ++ E+++FRV
Sbjct: 266 MNERVLEAMTERAEM-DEVERFQPLLDGLKS-GTTIALKVGCLQLINALITPAEELDFRV 323
Query: 339 HLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAY----LDNVFDVGALLEDAETKNAALER 394
H++ E +LGL + L L+ E++ ++VQ+ + ++ +D+ L+D +
Sbjct: 324 HIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNE 383
Query: 395 VEELEEN--------------ISHLSEKLQDTE---------NEAMSKIV---------- 421
V ++ N + HL D E E +S+IV
Sbjct: 384 VFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDF 443
Query: 422 -------ELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKE---EAIQRQSTLEKK 471
E+E + Q + V + K A + ++ E E + +S E+K
Sbjct: 444 KCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQK 503
Query: 472 IHEL----------------EKQGTIKIQKKGDGDIA-ILPVVASGTLSMGSEVVAGNSV 514
+ +L EKQ + G++A + + M S A +V
Sbjct: 504 LQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITV 563
Query: 515 GPTMGAASSGPLPPPPPPLPPSSDT---PETVQNGPVTPPMPPPPPPPPPP--------- 562
P++ S P+ PP PPLP S T P TPP PPPPPPPPPP
Sbjct: 564 PPSV--PSRAPV-PPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISS 620
Query: 563 ----------------------PPPPP-------------------------------PP 569
PPPPP PP
Sbjct: 621 PPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPP 680
Query: 570 PPPPLPGPAAETVPAPPL---------APPLPSA----------------PPLPGTSSP- 603
PPPPLPG A P PPL PPLP PP PG P
Sbjct: 681 PPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPP 740
Query: 604 ----------TVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVF------NEI 647
V GL K+ KP + + R P NW L ++ F +
Sbjct: 741 PPPFGFGVPAAPVLPFGLTPKKLYKP-EVQLRRP--NWSKLVAEDLSQDCFWTKVKEDRF 797
Query: 648 DDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLR 707
++ + L + F KT + K+ + +K ++ +L++ A+NL+I L
Sbjct: 798 ENNELFAKLTL-TFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLG 856
Query: 708 KAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDR 767
EI I + L ++ L++ +P ++K+L + E ++L++ ++
Sbjct: 857 SFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDE---YDDLAESEQ 913
Query: 768 FMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILA 827
F + + RL ++ + F F+E ++ + P++ ++ AA ++ S+ +LEI L
Sbjct: 914 FGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLL 973
Query: 828 LGNYMNSSKRGA-VYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELH 886
+GNYMN+ R A +GF + L L DTKSTD+K TLLH+++ + + Y V F +EL
Sbjct: 974 VGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELA 1033
Query: 887 YVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKE--------FILNNEGKLK 938
+VEKA+ VS EN+ ++ ++++ + +R+ T K+ F+ + + +
Sbjct: 1034 HVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYN 1093
Query: 939 KLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQAL 998
KL+ + + ++ +YF +PK FF F + QA +EN+ R++ E
Sbjct: 1094 KLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETE--- 1150
Query: 999 MEKLLEQEALMEQQDPKSPSHKSKRQQ 1025
EK+ + E+ + + + KR+Q
Sbjct: 1151 -EKMRRAKLAKEKAEKERLEKQQKREQ 1176
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 238 bits (606), Expect = 3e-62
Identities = 235/987 (23%), Positives = 409/987 (41%), Gaps = 199/987 (20%)
Query: 222 HVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLV---RG 278
H I CL+A MN ++G ++ + + +++ P +LL+A+C++
Sbjct: 215 HEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPED 274
Query: 279 GHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRV 338
+E +L A E+ E +RF+ L++ ++ I V +Q IN ++ E+++FRV
Sbjct: 275 MNERVLEAMTERAEM-DEVERFQPLLDGLKS-GTTIALKVGCLQLINALITPAEELDFRV 332
Query: 339 HLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAY----LDNVFDVGALLEDAETKNAALER 394
H++ E +LGL + L L+ E++ ++VQ+ + ++ +D+ L+D +
Sbjct: 333 HIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNE 392
Query: 395 VEELEEN--------------ISHLSEKLQDTE---------NEAMSKIV---------- 421
V ++ N + HL D E E +S+IV
Sbjct: 393 VFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDF 452
Query: 422 -------ELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKE---EAIQRQSTLEKK 471
E+E + Q + V + K A + ++ E E + +S E+K
Sbjct: 453 KCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQK 512
Query: 472 IHEL----------------EKQGTIKIQKKGDGDIA-ILPVVASGTLSMGSEVVAGNSV 514
+ +L EKQ + G++A + + M S A +V
Sbjct: 513 LQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITV 572
Query: 515 GPTMGAASSGPLPPPPPPLPPSSDT---PETVQNGPVTPPMPPPPPPPPPP--------- 562
P++ S P+ PP PPLP S T P TPP PPPPPPPPPP
Sbjct: 573 PPSV--PSRAPV-PPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISS 629
Query: 563 ----------------------PPPPP-------------------------------PP 569
PPPPP PP
Sbjct: 630 PPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPP 689
Query: 570 PPPPLPGPAAETVPAPPL---------APPLPSA----------------PPLPGTSSP- 603
PPPPLPG A P PPL PPLP PP PG P
Sbjct: 690 PPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPP 749
Query: 604 ----------TVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVF------NEI 647
V GL K+ KP + + R P NW L ++ F +
Sbjct: 750 PPPFGFGVPAAPVLPFGLTPKKLYKP-EVQLRRP--NWSKLVAEDLSQDCFWTKVKEDRF 806
Query: 648 DDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLR 707
++ + L + F KT + K+ + +K ++ +L++ A+NL+I L
Sbjct: 807 ENNELFAKLTL-TFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLG 865
Query: 708 KAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDR 767
EI I + L ++ L++ +P ++K+L + E ++L++ ++
Sbjct: 866 SFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDE---YDDLAESEQ 922
Query: 768 FMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILA 827
F + + RL ++ + F F+E ++ + P++ ++ AA ++ S+ +LEI L
Sbjct: 923 FGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLL 982
Query: 828 LGNYMNSSKRGA-VYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELH 886
+GNYMN+ R A +GF + L L DTKSTD+K TLLH+++ + + Y V F +EL
Sbjct: 983 VGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELA 1042
Query: 887 YVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKE--------FILNNEGKLK 938
+VEKA+ VS EN+ ++ ++++ + +R+ T K+ F+ + + +
Sbjct: 1043 HVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYN 1102
Query: 939 KLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQAL 998
KL+ + + ++ +YF +PK FF F + QA +EN+ R++ E
Sbjct: 1103 KLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETE--- 1159
Query: 999 MEKLLEQEALMEQQDPKSPSHKSKRQQ 1025
EK+ + E+ + + + KR+Q
Sbjct: 1160 -EKMRRAKLAKEKAEKERLEKQQKREQ 1185
>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
Length = 1240
Score = 237 bits (605), Expect = 4e-62
Identities = 221/896 (24%), Positives = 386/896 (43%), Gaps = 99/896 (11%)
Query: 224 CIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRG-GHEI 282
C+ C+RA+MN + G ++S+ V +++ +L+ N K V ELLAA+C+ GH +
Sbjct: 101 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVL 160
Query: 283 ILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQY 342
L A D++K VC ++ RF +M DN + ++V + IN V+ ED+ R L+
Sbjct: 161 TLDALDHYKTVCSQQYRFSIVMNELSGSDN-VPYVVTLLSVINAVILGPEDLRARTQLRN 219
Query: 343 EFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVE--ELEE 400
EF L L + L +L+ E L +Q++A+ + A ED E V+ +E
Sbjct: 220 EFIGLQLLDVLARLRDLEDADLLIQLEAFEE------AKAEDEEELLRVSGGVDMSSHQE 273
Query: 401 NISHLSEKLQDTENEA-----MSKIVELE-----KQLMQRNKELDVVREIYKDANTQVHT 450
+ L K+ + A + ++ LE QL+ E V R + ++ Q T
Sbjct: 274 VFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQECT 333
Query: 451 LRKMVKEKEEAIQR-------------QSTLEKKIHELEKQGTIKIQKKGDGDI------ 491
L ++V+ R Q+ L++ Q T + +G
Sbjct: 334 LEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAA 393
Query: 492 ----------AILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPP--------- 532
+IL V L + P + +S+ P PPPPPP
Sbjct: 394 CEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKA 453
Query: 533 LPPSSDTPETVQNGPVTPPMPPPPPPPP------PPPPPP------PPPPPPPLPGPAAE 580
LP + P G + PP PP PPP P PPPPPP PPPPPP LPG
Sbjct: 454 LPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWG 513
Query: 581 TVPAPPLAPPLPSAPPLPGTSSPTVV--FNSGLAAVKI---KKPIKTKFRMPVFNWVALK 635
P PP P +PP+ G +V + GL + + ++ RM NW L
Sbjct: 514 PPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLP 573
Query: 636 PNQIN-----GTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKIPQKGSNK 690
N + D E + D + E +F A P + + +K +
Sbjct: 574 SNVAREHNSMWASLSSPDAEAVEPDFS--SIERLFSFPAAKPKEPTMVAPR--ARKEPKE 629
Query: 691 VTLLEANRAKNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLR 750
+T L+A ++ NL I L++ + +E+ I D V+ ++ L++ LP ++E++ LR
Sbjct: 630 ITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLR 689
Query: 751 LYERERKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASV 810
+ ER L+ D F + I ++ M A + M+ P+ ++AA
Sbjct: 690 AFTEER---AKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACE 746
Query: 811 SIKSSQKLKKILEIILALGNYMN-SSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISN 869
S+ +S++L ++IL +GN++N S G GFK+ +L L +TKS + TLLH++
Sbjct: 747 SLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLE 806
Query: 870 VVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREY--TMHDHNTLLK 927
++ + + +L +AA ++LE + + + + T+R+ ++ +
Sbjct: 807 EAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYT 866
Query: 928 EFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEE 987
E + + + L + + + ++ Y E+ + F F + +A +E
Sbjct: 867 ERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKE 926
Query: 988 NELRKKQ---EQALMEKLLEQEALMEQQDPKSPSHKSKRQQQE------LIAELRR 1034
N+ RK+Q + ++L E+EA + + P K +Q+E L+A++R+
Sbjct: 927 NKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRK 982
>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
Length = 1249
Score = 237 bits (605), Expect = 4e-62
Identities = 221/896 (24%), Positives = 386/896 (43%), Gaps = 99/896 (11%)
Query: 224 CIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRG-GHEI 282
C+ C+RA+MN + G ++S+ V +++ +L+ N K V ELLAA+C+ GH +
Sbjct: 101 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVL 160
Query: 283 ILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQY 342
L A D++K VC ++ RF +M DN + ++V + IN V+ ED+ R L+
Sbjct: 161 TLDALDHYKTVCSQQYRFSIVMNELSGSDN-VPYVVTLLSVINAVILGPEDLRARTQLRN 219
Query: 343 EFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVE--ELEE 400
EF L L + L +L+ E L +Q++A+ + A ED E V+ +E
Sbjct: 220 EFIGLQLLDVLARLRDLEDADLLIQLEAFEE------AKAEDEEELLRVSGGVDMSSHQE 273
Query: 401 NISHLSEKLQDTENEA-----MSKIVELE-----KQLMQRNKELDVVREIYKDANTQVHT 450
+ L K+ + A + ++ LE QL+ E V R + ++ Q T
Sbjct: 274 VFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQECT 333
Query: 451 LRKMVKEKEEAIQR-------------QSTLEKKIHELEKQGTIKIQKKGDGDI------ 491
L ++V+ R Q+ L++ Q T + +G
Sbjct: 334 LEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAA 393
Query: 492 ----------AILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPP--------- 532
+IL V L + P + +S+ P PPPPPP
Sbjct: 394 CEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKA 453
Query: 533 LPPSSDTPETVQNGPVTPPMPPPPPPPP------PPPPPP------PPPPPPPLPGPAAE 580
LP + P G + PP PP PPP P PPPPPP PPPPPP LPG
Sbjct: 454 LPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWG 513
Query: 581 TVPAPPLAPPLPSAPPLPGTSSPTVV--FNSGLAAVKI---KKPIKTKFRMPVFNWVALK 635
P PP P +PP+ G +V + GL + + ++ RM NW L
Sbjct: 514 PPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLP 573
Query: 636 PNQIN-----GTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKIPQKGSNK 690
N + D E + D + E +F A P + + +K +
Sbjct: 574 SNVAREHNSMWASLSSPDAEAVEPDFS--SIERLFSFPAAKPKEPTMVAPR--ARKEPKE 629
Query: 691 VTLLEANRAKNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLR 750
+T L+A ++ NL I L++ + +E+ I D V+ ++ L++ LP ++E++ LR
Sbjct: 630 ITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLR 689
Query: 751 LYERERKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASV 810
+ ER L+ D F + I ++ M A + M+ P+ ++AA
Sbjct: 690 AFTEER---AKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACE 746
Query: 811 SIKSSQKLKKILEIILALGNYMN-SSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISN 869
S+ +S++L ++IL +GN++N S G GFK+ +L L +TKS + TLLH++
Sbjct: 747 SLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLE 806
Query: 870 VVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREY--TMHDHNTLLK 927
++ + + +L +AA ++LE + + + + T+R+ ++ +
Sbjct: 807 EAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYT 866
Query: 928 EFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEE 987
E + + + L + + + ++ Y E+ + F F + +A +E
Sbjct: 867 ERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKE 926
Query: 988 NELRKKQ---EQALMEKLLEQEALMEQQDPKSPSHKSKRQQQE------LIAELRR 1034
N+ RK+Q + ++L E+EA + + P K +Q+E L+A++R+
Sbjct: 927 NKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRK 982
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 179 bits (453), Expect = 2e-44
Identities = 155/566 (27%), Positives = 261/566 (46%), Gaps = 62/566 (10%)
Query: 516 PTMGAASSGP--LPPPPPPLPPSSDTPETVQN-------GPVT--PPMPPPPPPPPPPPP 564
P G AS+ LPPPP +PP P + + PV+ PP+PPPPPPPPP PP
Sbjct: 633 PMEGMASNQQKALPPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPPPPLPP 692
Query: 565 -----PPPPPPPPPLP-GPAAETVPAPPLAPPLPS-APPLPGTSSPTVVFNSGLAAVKI- 616
PPPPPPPPPLP PA PP APP P APP P P + F G ++ +
Sbjct: 693 PSSAGPPPPPPPPPLPNSPAPPNPGGPPPAPPPPGLAPPPP----PGLFFGLGSSSSQCP 748
Query: 617 -KKPIKTKFRMPVFNWVAL----KPNQINGTVFNEIDDERILEDLNVDEFEEIF-KTKAQ 670
K I+ M W + + T+++ +++ I + EFE +F K Q
Sbjct: 749 RKPAIEPSCPMKPLYWTRIQISDRSQNATPTLWDSLEEPDIRDP---SEFEYLFSKDTTQ 805
Query: 671 GPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAIHVFDLKTLPV 730
LS + +K K + LL+ R++ + I + +I +AI D + +
Sbjct: 806 QKKKPLSETYEK-KNKVKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAIFNVDDSVVDL 864
Query: 731 DFVECLMRFLPTENE-VKVLRLYERER-KPLENLSDEDRFMMQFSKIERLMQKMTIMAFI 788
+ + L E+E VK+ + YE + + L+ L ++F+ + ++I ++ + F
Sbjct: 865 ETLAALYENRAQEDELVKIRKYYETSKEEELKLLDKPEQFLHELAQIPNFAERAQCIIFR 924
Query: 789 GNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSK--RGAVYGFKLQ 846
F+E I L ++ I AS + + +K IL +ILA GNYMN RG G+ L+
Sbjct: 925 SVFSEGITSLHRKVEIITRASKDLLHVKSVKDILALILAFGNYMNGGNRTRGQADGYSLE 984
Query: 847 SLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEK------AAAVSLENVL 900
L L D KS D L+ Y+ Y Q + + + + A+ V E+++
Sbjct: 985 ILPKLKDVKSRDNGINLVDYVVKYYLRYYDQEAGTEKSVFPLPEPQDFFLASQVKFEDLI 1044
Query: 901 LDVKELQRGMDLTKREYT----------MHDHNTLLKEFILNNEGKLKKLQDDAKIAQDA 950
D+++L+R ++ ++++ + L+EF + + K + + AQ +
Sbjct: 1045 KDLRKLKRQLEASEKQMVVVCKESPKEYLQPFKDKLEEFFQKAKKEHKMEESHLENAQKS 1104
Query: 951 FDDVVKYFGENPKT----TPPSVFFPVFVRFVKAYK-----QAEEENELRKKQEQALMEK 1001
F+ V+YFG PK+ PS F V+ F +K +++ ++ R K Q + K
Sbjct: 1105 FETTVRYFGMKPKSGEKEITPSYVFMVWYEFCSDFKTIWKRESKNISKERLKMAQESVSK 1164
Query: 1002 LLEQEALMEQQDPKSPSHKSKRQQQE 1027
L ++ + ++ + S K + +Q+E
Sbjct: 1165 LTSEKKVETKKINPTASLKERLRQKE 1190
Score = 32.3 bits (72), Expect = 2.5
Identities = 34/145 (23%), Positives = 61/145 (42%), Gaps = 17/145 (11%)
Query: 24 PMPEPGELEERFAIVLNAMNLPPDKARLLRQYD-NEKKWELICDQERFQVKNPPHTYIQK 82
P+PEP + A + +L D +L RQ + +EK+ ++C K P Y+Q
Sbjct: 1025 PLPEPQDFF--LASQVKFEDLIKDLRKLKRQLEASEKQMVVVC-------KESPKEYLQP 1075
Query: 83 LKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKG-LDVLVEYLS 141
K L+ + K +++ES L + S T VR F + G ++ Y+
Sbjct: 1076 FKDKLEEFFQKAKKEHKMEESH--LENAQKSFETT----VRYFGMKPKSGEKEITPSYVF 1129
Query: 142 FAQYAVTFDFESVESTVESSVDKSK 166
Y DF+++ ++ K +
Sbjct: 1130 MVWYEFCSDFKTIWKRESKNISKER 1154
>gi|145309324 FH2 domain containing 1 [Homo sapiens]
Length = 1143
Score = 168 bits (426), Expect = 2e-41
Identities = 127/468 (27%), Positives = 214/468 (45%), Gaps = 32/468 (6%)
Query: 555 PPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPL--PGTSSPTVVFNSGLA 612
PPP PPPPPPPPPP PP + P PP PPLP PP+ P P +G +
Sbjct: 30 PPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPPTTHMNGYS 89
Query: 613 AVKIKKPIKTKFRMPVFNWVALKPNQING--TVFNEIDDERILEDLNVDEFEEIFKTKAQ 670
+ KK RM F W + Q+ G ++ + ++ EE+F +
Sbjct: 90 HLGKKK------RMRSFFWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEELFGQQE- 142
Query: 671 GPAIDLSSSKQKIPQKG----------SNKVTLLEANRAKNLAITLRKAGKTADEICKAI 720
++K +P++G ++T+L+A R+ N+ I L++ K+ I + I
Sbjct: 143 ------DTTKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQFKKSPRSIVEDI 196
Query: 721 HVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQ 780
H + + + ++FLP EVK L+ + + + LS D F+ ++
Sbjct: 197 HQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGD---VSKLSLADSFLYGLIQVPNYSL 253
Query: 781 KMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNS-SKRGA 839
++ M F S L + + A + S ++L IL ++L GN MN+ G
Sbjct: 254 RIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGN 313
Query: 840 VYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENV 899
GFKL SL L DTK+ LLH+++ ++K + F +LH+V+K A +SLEN
Sbjct: 314 AVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENT 373
Query: 900 LLDVKEL-QRGMDLTKREYTMHDHNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYF 958
++ L R L + + +++F+ KL++L+ + QD ++ +F
Sbjct: 374 EAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAIEKLRELECWKQELQDEAYTLIDFF 433
Query: 959 GENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQE 1006
E+ KT F +F F + +A ++N R+ QE +++L EQE
Sbjct: 434 CEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEQE 481
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 155 bits (392), Expect = 2e-37
Identities = 152/589 (25%), Positives = 253/589 (42%), Gaps = 95/589 (16%)
Query: 516 PTMGAASSGPLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP---- 563
P G PLP PPPPPLP + P G PP PP P PPPPP P
Sbjct: 1136 PGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGI 1195
Query: 564 PPPPP------PPPPPLPGPAAETVPAPPLAPPLPSAPPLP-------------GTSS-- 602
PPPPP PPPPPLPG PAPPL PP PP P G+S+
Sbjct: 1196 PPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLP 1255
Query: 603 ------------PTVVFNSGLAAVK--IKKPIKTKFRMPVFNWVAL----KPNQINGTVF 644
P+ +F G+ K K+PI+ M W + K + ++
Sbjct: 1256 TPQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRIQLHSKRDSSTSLIW 1315
Query: 645 NEIDDERILEDLNVDEFEEIF-KTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLA 703
+I++ I + EFEE+F KT + +S + K K V LL R++ +
Sbjct: 1316 EKIEEPSI----DCHEFEELFSKTAVKERKKPISDTISK--TKAKQVVKLLSNKRSQAVG 1369
Query: 704 ITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLEN-- 761
I + +I A+ D + ++ ++ L +E++ + + R K EN
Sbjct: 1370 ILMSSLHLDMKDIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIEKHGRSSKDKENAK 1429
Query: 762 -LSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKK 820
L ++F+ + S I +++ + F F+ESI + +L + ++K+ + +
Sbjct: 1430 SLDKPEQFLYELSLIPNFSERVFCILFQSTFSESICSIRRKLELLQKLCETLKNGPGVMQ 1489
Query: 821 ILEIILALGNYMN--SSKRGAVYGFKLQSLDLLLDTKSTDRKQTLL-----HYISNVVKE 873
+L ++LA GNYMN + RG GF L L L D KS+D ++LL +Y+ N ++
Sbjct: 1490 VLGLVLAFGNYMNGGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLSYIVSYYLRNFDED 1549
Query: 874 KYHQVSLF-YNELHYVEKAAAVSLENVLLDVKELQRGM-----------DLTKREYTMHD 921
+ LF E + +A+ + E+ D+++L++ + ++ +E+ M
Sbjct: 1550 AGKEQCLFPLPEPQDLFQASQMKFEDFQKDLRKLKKDLKACEVEAGKVYQVSSKEH-MQP 1608
Query: 922 HNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGENP----KTTPPSVFFPVFVRF 977
+++FI+ + + ++ F + YF P K P+ FF ++ F
Sbjct: 1609 FKENMEQFIIQAKIDQEAEENSLTETHKCFLETTAYFFMKPKLGEKEVSPNAFFSIWHEF 1668
Query: 978 VKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDPKS-----PSHKS 1021
+K + +K+ + L E++ E E + Q+ KS P H S
Sbjct: 1669 SSDFK-----DFWKKENKLLLQERVKEAEEVCRQKKGKSLYKIKPRHDS 1712
Score = 81.6 bits (200), Expect = 4e-15
Identities = 58/138 (42%), Positives = 62/138 (44%), Gaps = 50/138 (36%)
Query: 516 PTMGAASSGPLP----PPPPPLPPSSDTPETVQNG---PVTPPMP----PPPPP------ 558
P G PLP PPPPPLP ++ P G P+ PP+P PPPPP
Sbjct: 927 PGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGI 986
Query: 559 PPPPP------PPPPP------PPPPPLPG---------PAAETVPAPPLA-------PP 590
PPPPP PPPPP PPPPPLPG P A P PPL PP
Sbjct: 987 PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1046
Query: 591 LPSA-----PPLPGTSSP 603
LP A PPLPG P
Sbjct: 1047 LPGAGIPPPPPLPGAGIP 1064
Score = 80.5 bits (197), Expect = 8e-15
Identities = 54/118 (45%), Positives = 55/118 (46%), Gaps = 32/118 (27%)
Query: 516 PTMGAASSGPLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP---- 563
P G PLP PPPPPLP + P G PP PP P PPPPP P
Sbjct: 971 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1030
Query: 564 PPPPP------PPPPPLPGPAAETVPAPPLA-------PPLPSA-----PPLPGTSSP 603
PPPPP PPPPPLPG A P PPL PPLP A PPLPG P
Sbjct: 1031 PPPPPLPGAGIPPPPPLPG--AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1086
Score = 80.5 bits (197), Expect = 8e-15
Identities = 54/118 (45%), Positives = 55/118 (46%), Gaps = 32/118 (27%)
Query: 516 PTMGAASSGPLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP---- 563
P G PLP PPPPPLP + P G PP PP P PPPPP P
Sbjct: 982 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1041
Query: 564 PPPPP------PPPPPLPGPAAETVPAPPLA-------PPLPSA-----PPLPGTSSP 603
PPPPP PPPPPLPG A P PPL PPLP A PPLPG P
Sbjct: 1042 PPPPPLPGAGIPPPPPLPG--AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1097
Score = 80.5 bits (197), Expect = 8e-15
Identities = 54/118 (45%), Positives = 55/118 (46%), Gaps = 32/118 (27%)
Query: 516 PTMGAASSGPLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP---- 563
P G PLP PPPPPLP + P G PP PP P PPPPP P
Sbjct: 993 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1052
Query: 564 PPPPP------PPPPPLPGPAAETVPAPPL-------APPLPSA-----PPLPGTSSP 603
PPPPP PPPPPLPG A P PPL PPLP A PPLPG P
Sbjct: 1053 PPPPPLPGAGIPPPPPLPG--AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIP 1108
Score = 80.1 bits (196), Expect = 1e-14
Identities = 54/118 (45%), Positives = 55/118 (46%), Gaps = 32/118 (27%)
Query: 516 PTMGAASSGPLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP---- 563
P G PLP PPPPPLP + P G PP PP P PPPPP P
Sbjct: 960 PGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1019
Query: 564 PPPPP------PPPPPLPGPAAETVPAPPL-------APPLPSA-----PPLPGTSSP 603
PPPPP PPPPPLPG A P PPL PPLP A PPLPG P
Sbjct: 1020 PPPPPLPGAGIPPPPPLPG--AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1075
Score = 80.1 bits (196), Expect = 1e-14
Identities = 49/108 (45%), Positives = 52/108 (48%), Gaps = 23/108 (21%)
Query: 516 PTMGAASSGPLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP---- 563
P G PLP PPPPPLP + P G PP PP P PPPPP P
Sbjct: 1015 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1074
Query: 564 PPPPP------PPPPPLPGPAAETVPAPPLAPP--LPSAPPLPGTSSP 603
PPPPP PPPPPLPG +P PP P +P PPLPG P
Sbjct: 1075 PPPPPLPGAGIPPPPPLPGAG---IPPPPPLPGVGIPPPPPLPGAGIP 1119
Score = 80.1 bits (196), Expect = 1e-14
Identities = 52/119 (43%), Positives = 56/119 (47%), Gaps = 34/119 (28%)
Query: 516 PTMGAASSGPLP----PPPPPLPPSSDTPETVQNG---PVTPPMP----PPPPP------ 558
P G PLP PPPPPLP + P G P PP+P PPPPP
Sbjct: 1026 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1085
Query: 559 PPPPP------PPPPP------PPPPPLPGPAAETVPAPPLAP--PLPSAPPLPGTSSP 603
PPPPP PPPPP PPPPPLPG +P PP P +P PPLPG P
Sbjct: 1086 PPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAG---IPPPPPLPGAGIPPPPPLPGAGIP 1141
Score = 80.1 bits (196), Expect = 1e-14
Identities = 49/108 (45%), Positives = 52/108 (48%), Gaps = 23/108 (21%)
Query: 516 PTMGAASSGPLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP---- 563
P G PLP PPPPPLP + P G PP PP P PPPPP P
Sbjct: 1059 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGI 1118
Query: 564 PPPPP------PPPPPLPGPAAETVPAPPLAPP--LPSAPPLPGTSSP 603
PPPPP PPPPPLPG +P PP P +P PPLPG P
Sbjct: 1119 PPPPPLPGAGIPPPPPLPGAG---IPPPPPLPRVGIPPPPPLPGAGIP 1163
Score = 80.1 bits (196), Expect = 1e-14
Identities = 52/119 (43%), Positives = 56/119 (47%), Gaps = 34/119 (28%)
Query: 516 PTMGAASSGPLP----PPPPPLPPSSDTPETVQNG---PVTPPMP----PPPPP------ 558
P G PLP PPPPPLP + P G P PP+P PPPPP
Sbjct: 1070 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGI 1129
Query: 559 PPPPP------PPPPP------PPPPPLPGPAAETVPAPPLAP--PLPSAPPLPGTSSP 603
PPPPP PPPPP PPPPPLPG +P PP P +P PPLPG P
Sbjct: 1130 PPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAG---IPPPPPLPGAGIPPPPPLPGVGIP 1185
Score = 80.1 bits (196), Expect = 1e-14
Identities = 49/108 (45%), Positives = 52/108 (48%), Gaps = 23/108 (21%)
Query: 516 PTMGAASSGPLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP---- 563
P G PLP PPPPPLP + P G PP PP P PPPPP P
Sbjct: 1092 PGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGI 1151
Query: 564 PPPPP------PPPPPLPGPAAETVPAPPLAPP--LPSAPPLPGTSSP 603
PPPPP PPPPPLPG +P PP P +P PPLPG P
Sbjct: 1152 PPPPPLPGAGIPPPPPLPGAG---IPPPPPLPGVGIPPPPPLPGVGIP 1196
Score = 77.8 bits (190), Expect = 5e-14
Identities = 51/114 (44%), Positives = 56/114 (49%), Gaps = 34/114 (29%)
Query: 524 GPLPPPPPPLP-------PSSDTPET--VQNGPVTPPMPPPPP----PPPPPPP------ 564
G +PPPPPPLP PS+ P+ +Q + PP PPP P PPPPP P
Sbjct: 874 GMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILP 933
Query: 565 -PPPP----PPPPPLPGPAAETVP-----APPLAPPLPSA-----PPLPGTSSP 603
PP P PPPPPLPG A P PL PPLP A PPLPG P
Sbjct: 934 LPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIP 987
Score = 75.9 bits (185), Expect = 2e-13
Identities = 49/104 (47%), Positives = 51/104 (49%), Gaps = 28/104 (26%)
Query: 526 LPPPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP----PPPPP------PPP 571
LPPPPPPLP + P G P+PP P PPPPP P PPPPP P P
Sbjct: 908 LPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLP 967
Query: 572 PPLPGPAAETVPAPPL-------APPLPSA-----PPLPGTSSP 603
PPLPG A P PPL PPLP A PPLPG P
Sbjct: 968 PPLPG--AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1009
Score = 75.1 bits (183), Expect = 3e-13
Identities = 54/137 (39%), Positives = 57/137 (41%), Gaps = 44/137 (32%)
Query: 511 GNSVGPTMGAASSGPLP---------PPPPPLPPSSDTPETVQNGPVTPPMPPPP----P 557
G + P +G P PPPPPLP + P G PP PP P P
Sbjct: 1038 GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1097
Query: 558 PPPPPP----PPPPP------PPPPPLPG---------PAAETVPAPPL-------APPL 591
PPPP P PPPPP PPPPPLPG P A P PPL PPL
Sbjct: 1098 PPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPL 1157
Query: 592 PSA-----PPLPGTSSP 603
P A PPLPG P
Sbjct: 1158 PGAGIPPPPPLPGAGIP 1174
Score = 73.6 bits (179), Expect = 1e-12
Identities = 53/120 (44%), Positives = 54/120 (45%), Gaps = 43/120 (35%)
Query: 525 PLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP-----PPPP--------PPP---- 563
PLP PPPPPLP + P G PP PP P PPPP PPP
Sbjct: 914 PLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGA 973
Query: 564 --PPPPP------PPPPPLPGPAAETVPAPPL-------APPLPSA-----PPLPGTSSP 603
PPPPP PPPPPLPG A P PPL PPLP A PPLPG P
Sbjct: 974 GIPPPPPLPGAGIPPPPPLPG--AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1031
Score = 70.1 bits (170), Expect = 1e-11
Identities = 47/112 (41%), Positives = 50/112 (44%), Gaps = 38/112 (33%)
Query: 528 PPPPPLPPSSDTPETVQNGPVTPPMPPPPP-----------PPPPP-------PPPPPP- 568
P PPPLP + + G V PP PP P P PPP PPPPPP
Sbjct: 856 PSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPL 915
Query: 569 -----PPPPPLPGPAAETVPAPPL-------APPLPSA-----PPLPGTSSP 603
PPPPPLPG A +P PPL PPLP A PPLPG P
Sbjct: 916 PGAGIPPPPPLPG--AGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIP 965
Score = 55.8 bits (133), Expect = 2e-07
Identities = 72/292 (24%), Positives = 110/292 (37%), Gaps = 78/292 (26%)
Query: 382 LEDAETKNAAL--------------ERVEELEENISHLSEKLQDTENEAMSKIVELEKQL 427
LEDAET++ + E V+ E + + ++L+ T + +KI ELE+Q
Sbjct: 638 LEDAETESQSAVSETPQKRSDAVQKEVVDMKSEGQATVIQQLEQTIEDLRTKIAELERQY 697
Query: 428 MQRNKELDVVREIYKDANTQVHTL-RKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKK 486
+ E+ + ++ T + + ++ +E+ ++ LE K +I+
Sbjct: 698 PALDTEVASGHQGLENGVTASGDVCLEALRLEEKEVRHHRILEAK--------SIQTSPT 749
Query: 487 GDGDIAILPVV-------------ASGT----LSMGSEVVAGNSVGPTMGA---ASSGPL 526
+G + LP V SG S S +V+ + + + S
Sbjct: 750 EEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQ 809
Query: 527 PPPPPPL-------PPSSDTPETVQ-------------------NGPVTPPMPPPPPPPP 560
PPPPP L P S P ++ N P PP+P
Sbjct: 810 PPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSS 869
Query: 561 PPPPPPPPPPPPPLPGPAAETVP--APPLAPPL-------PSAPPLPGTSSP 603
P PPPPPPLPG T+P A P PPL P PPLPG P
Sbjct: 870 MPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIP 921
Score = 37.4 bits (85), Expect = 0.078
Identities = 23/77 (29%), Positives = 30/77 (38%), Gaps = 1/77 (1%)
Query: 514 VGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPP-PPPPPPPPPPPPPP 572
+GP+ GA + P L SD PE++ P P PP P P P P P
Sbjct: 254 LGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAPSLPAAQPA 313
Query: 573 PLPGPAAETVPAPPLAP 589
P++ P P P
Sbjct: 314 AKDSPSSTAFPFPEAGP 330
Score = 33.5 bits (75), Expect = 1.1
Identities = 65/285 (22%), Positives = 104/285 (36%), Gaps = 66/285 (23%)
Query: 408 KLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQST 467
+L+D E E+ S + E + K D V++ D ++ ++++ E+ I+
Sbjct: 637 RLEDAETESQSAVSETPQ------KRSDAVQKEVVDMKSEGQAT--VIQQLEQTIE---D 685
Query: 468 LEKKIHELEKQGTIKIQKKGDGDIAILP-VVASGTLSMGS-----------EVVAGNSVG 515
L KI ELE+Q + G + V ASG + + + ++ S+
Sbjct: 686 LRTKIAELERQYPALDTEVASGHQGLENGVTASGDVCLEALRLEEKEVRHHRILEAKSI- 744
Query: 516 PTMGAASSGPLPPPP-------PPLPPSSDT-PETVQNGPVTPPMPPPP-----PPPPPP 562
T G L PP PP PP +++ P+T ++ + P P
Sbjct: 745 QTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPT 804
Query: 563 PPPPPPPPPPPLPGPAAETVPAPPLAPP------------------------LPSAPPLP 598
PPPPP L A + P PP +PS PPLP
Sbjct: 805 QSISQPPPPPSLLWSAGQGQPGSQ--PPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLP 862
Query: 599 GTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVAL-KPNQINGT 642
T S + + GL V P +P A+ +P + GT
Sbjct: 863 CTESSSSM--PGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGT 905
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 135 bits (339), Expect = 3e-31
Identities = 115/478 (24%), Positives = 205/478 (42%), Gaps = 63/478 (13%)
Query: 527 PPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPP 586
PPPPPPLP P + + P P P PPPPPPPLP
Sbjct: 756 PPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLP----------- 804
Query: 587 LAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNE 646
PP+P APP+ + GL ++ + + W ++ ++ GT++ +
Sbjct: 805 --PPVPCAPPM---------LSRGLGH---RRSETSHMSVKRLRWEQVENSE--GTIWGQ 848
Query: 647 IDDERILEDLNVDEFEEIFK-------TKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRA 699
+ ED + D+ ++ K Q PA + + P + V +L +A
Sbjct: 849 LG-----EDSDYDKLSDMVKYLDLELHFGTQKPAKPVPGPE---PFRKKEVVEILSHKKA 900
Query: 700 KNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPL 759
N +I L + E+ + + + + L + L+ F P +E + Y+ R+
Sbjct: 901 YNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEE---QRYQAFREAP 957
Query: 760 ENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLK 819
LS+ D+F++Q + ++ + F E + + L + AS+ +K+S+KL
Sbjct: 958 GRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLA 1017
Query: 820 KILEIILALGNYMNSS--KRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQ 877
KILE +LA+GNY+N K GFK+ L L TK+ D K T LH ++ + + + +
Sbjct: 1018 KILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPE 1077
Query: 878 VSLFYNELHYVEKAAAVSLENVLLDVKEL-----------QRGMDLTKREYTMHDHNTLL 926
+ F +L V AA V+ + D+ +L Q ++ ++ M ++
Sbjct: 1078 LLGFAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAM-----VM 1132
Query: 927 KEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQA 984
F+ + L+ L + A + + +FGE+ K T FF +F F+ +++A
Sbjct: 1133 SSFLETAQPALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERA 1190
Score = 31.2 bits (69), Expect = 5.6
Identities = 19/54 (35%), Positives = 21/54 (38%), Gaps = 23/54 (42%)
Query: 513 SVGPTMGAAS-----SGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPP 561
S GP A S P+PPPPP PP+PPP P PP
Sbjct: 777 SRGPAQALAKPLTQLSHPVPPPPP------------------PPLPPPVPCAPP 812
>gi|58331242 formin homology 2 domain containing 3 [Homo sapiens]
Length = 1439
Score = 115 bits (287), Expect = 3e-25
Identities = 112/467 (23%), Positives = 221/467 (47%), Gaps = 47/467 (10%)
Query: 553 PPPPPPPPPP----PPPPPPP-----PPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSP 603
P PPPPPPP PPPPPPP PPPP+PG + PP PP+ +AP G S
Sbjct: 844 PGPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPG----NLLVPP--PPVFNAPQGLGWSQ- 896
Query: 604 TVVFNSGLAAVKIKKPIKTKF-RMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFE 662
V K KK I+ + + F+W + ++++++ ++ + E
Sbjct: 897 --VPRGQPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKV----DTSRLE 950
Query: 663 EIFKTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANR--AKNLAITLRKAGKTADEICKAI 720
+F++K++ +LS SK+ ++ +L++ R A N+ +T+ +T I AI
Sbjct: 951 HLFESKSK----ELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRT---IKIAI 1003
Query: 721 HVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQ 780
FD L + +E ++ +PT+ E + ++ + P L ++F++ S I L
Sbjct: 1004 LNFDEYALNKEGIEKILTMIPTDEEKQKIQ-EAQLANPEIPLGSAEQFLLTLSSISELSA 1062
Query: 781 KMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAV 840
++ + AF ++ + + + L + +++++ L IL +LA+GN++N + A
Sbjct: 1063 RLHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKA- 1121
Query: 841 YGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVL 900
F+L L+ + + K T KQ+LLH++ +V E + S Y+E+ + ++A V + +
Sbjct: 1122 --FELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQ 1179
Query: 901 LDVKELQRGMDLT---KREYTMHDHNTLLK----EFILNNEGKLKKLQDDAKIAQDAFDD 953
++ +++R + + H+ +LK EF+ + ++ L+ + + F
Sbjct: 1180 DNLCQMERRCKASWDHLKAIAKHEMKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHS 1239
Query: 954 VVKYFGENP---KTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQA 997
+ + G P + + F + F Y+ E L++KQ++A
Sbjct: 1240 FLLFMGHPPYAIREVNINKFCRIISEFALEYR-TTRERVLQQKQKRA 1285
>gi|118572599 formin homology 2 domain containing 1 [Homo sapiens]
Length = 1164
Score = 108 bits (271), Expect = 2e-23
Identities = 96/383 (25%), Positives = 162/383 (42%), Gaps = 47/383 (12%)
Query: 526 LPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAP 585
+P P PPLP S +PPPPP PPPPP P PPPPPLP A
Sbjct: 569 IPAPSPPLPLLSG-------------VPPPPPLPPPPPIKGPFPPPPPLP-------LAA 608
Query: 586 PLAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFN 645
PL +P + LP +F L ++F W +L P +
Sbjct: 609 PLPHSVPDSSALPTKRKTVKLFWRELKLAGGHGVSASRFGPCATLWASLDPVSV------ 662
Query: 646 EIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAIT 705
D LE L +E+ +K G + T+L+ R+ + I
Sbjct: 663 ---DTARLEHLFESRAKEVLPSKKAG-------------EGRRTMTTVLDPKRSNAINIG 706
Query: 706 LRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDE 765
L I A+ FD + D +E L+ +PTE E + + + + L
Sbjct: 707 LTTL-PPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDIP-LGPA 764
Query: 766 DRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEII 825
+ F+M + I L ++ + AF ++ + + L + + + + IL +
Sbjct: 765 ENFLMTLASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATL 824
Query: 826 LALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNEL 885
LA+GN++N S+ GF+L L+ + + K T R+Q+LLH++ ++V + + S Y+E+
Sbjct: 825 LAVGNFLNGSQSS---GFELSYLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEI 881
Query: 886 HYVEKAAAVSLENVLLDVKELQR 908
+ + A V E + ++ +L+R
Sbjct: 882 PALTRCAKVDFEQLTENLGQLER 904
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 92.0 bits (227), Expect = 3e-18
Identities = 76/250 (30%), Positives = 116/250 (46%), Gaps = 29/250 (11%)
Query: 383 EDAETKNAALERVEELEENISHLSEKLQDTEN-EAMSKIVELEKQ-LMQRNKELDVVREI 440
E E + ER+E L + Q+ E E + + LE+Q ++R + LD R+
Sbjct: 169 ERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE 228
Query: 441 YKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIK-IQKKGDGDIAILPVVAS 499
++ L ++ +E++E +RQ LE++ E E++ I + + V+
Sbjct: 229 RQERER----LERLERERQER-ERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGD 283
Query: 500 GTLSM-GSEVVAGNSVGPTMGAASSGPL-PPPPPPLPPSSDTPETVQNGPVTPPMPPPPP 557
+ S G + + + P+ GPL PPPPPPLPP Q PP P PPP
Sbjct: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGP-----AQASVALPPPPGPPP 338
Query: 558 PPP----PPPPPPPPPP-PPPLPGPAAETVPAPPLAPPLPSA----PPLPGTSSPTVVFN 608
PPP PPPPPPPPP P +P P P PP APPLP++ + + P
Sbjct: 339 PPPLPSTGPPPPPPPPPLPNQVPPP-----PPPPPAPPLPASGFFLASMSEDNRPLTGLA 393
Query: 609 SGLAAVKIKK 618
+ +A K++K
Sbjct: 394 AAIAGAKLRK 403
Score = 32.0 bits (71), Expect = 3.3
Identities = 16/60 (26%), Positives = 36/60 (60%), Gaps = 1/60 (1%)
Query: 982 KQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAELRRRQVKDNR 1041
+Q E E + R++QE+ ++ LE++ +E+Q+ + + +RQ++E + L R + + R
Sbjct: 189 EQLERERQERERQERLERQERLERQERLERQE-RLDRERQERQERERLERLERERQERER 247
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 92.0 bits (227), Expect = 3e-18
Identities = 76/250 (30%), Positives = 116/250 (46%), Gaps = 29/250 (11%)
Query: 383 EDAETKNAALERVEELEENISHLSEKLQDTEN-EAMSKIVELEKQ-LMQRNKELDVVREI 440
E E + ER+E L + Q+ E E + + LE+Q ++R + LD R+
Sbjct: 169 ERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE 228
Query: 441 YKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIK-IQKKGDGDIAILPVVAS 499
++ L ++ +E++E +RQ LE++ E E++ I + + V+
Sbjct: 229 RQERER----LERLERERQER-ERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGD 283
Query: 500 GTLSM-GSEVVAGNSVGPTMGAASSGPL-PPPPPPLPPSSDTPETVQNGPVTPPMPPPPP 557
+ S G + + + P+ GPL PPPPPPLPP Q PP P PPP
Sbjct: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGP-----AQASVALPPPPGPPP 338
Query: 558 PPP----PPPPPPPPPP-PPPLPGPAAETVPAPPLAPPLPSA----PPLPGTSSPTVVFN 608
PPP PPPPPPPPP P +P P P PP APPLP++ + + P
Sbjct: 339 PPPLPSTGPPPPPPPPPLPNQVPPP-----PPPPPAPPLPASGFFLASMSEDNRPLTGLA 393
Query: 609 SGLAAVKIKK 618
+ +A K++K
Sbjct: 394 AAIAGAKLRK 403
Score = 32.0 bits (71), Expect = 3.3
Identities = 16/60 (26%), Positives = 36/60 (60%), Gaps = 1/60 (1%)
Query: 982 KQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAELRRRQVKDNR 1041
+Q E E + R++QE+ ++ LE++ +E+Q+ + + +RQ++E + L R + + R
Sbjct: 189 EQLERERQERERQERLERQERLERQERLERQE-RLDRERQERQERERLERLERERQERER 247
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 90.9 bits (224), Expect = 6e-18
Identities = 54/144 (37%), Positives = 63/144 (43%), Gaps = 8/144 (5%)
Query: 515 GPTMGAASSGPLPPPPPPLPP--SSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPP-- 570
GP + A++ P PPP P LP S+ TPE PP PPP P P P PPPPPPPP
Sbjct: 1421 GPPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQP 1480
Query: 571 ----PPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRM 626
PPPL P + P PPL PP P A P P P + P +
Sbjct: 1481 ALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPEL 1540
Query: 627 PVFNWVALKPNQINGTVFNEIDDE 650
P + L Q V E D+E
Sbjct: 1541 PDTRPLHLAKKQETAAVCGETDEE 1564
Score = 55.8 bits (133), Expect = 2e-07
Identities = 56/209 (26%), Positives = 68/209 (32%), Gaps = 73/209 (34%)
Query: 479 GTIKIQKKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSD 538
G +K +KKG P + + VV + +GA PPPPP +
Sbjct: 723 GRLKEKKKGPERGGETPE------GLATSVVHYGAGAKELGAFLQKSPPPPPPTAQSTQP 776
Query: 539 TPETV---QNGPVTPPMPPPPPPP-------------------------------PPPPP 564
TP + GP P + PPPPP P PP
Sbjct: 777 TPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPP 836
Query: 565 PPPPPPPPPLP------------GPAAETVPAPPLAP------------------PLPSA 594
PPPPPPPPP+P PAA P+P L P PLP A
Sbjct: 837 PPPPPPPPPMPLQLEAHLRSHGLEPAA---PSPRLRPEESLDPPGAMQELLGALEPLPPA 893
Query: 595 PPLPGTSSPTVVFNSGLAAVKIKKPIKTK 623
P G P A + P TK
Sbjct: 894 PGDTGVGPPNSEGKDPAGAYRSPSPQGTK 922
Score = 52.8 bits (125), Expect = 2e-06
Identities = 27/70 (38%), Positives = 29/70 (41%), Gaps = 17/70 (24%)
Query: 514 VGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPP 573
V PT + PLPPPPPP PS PPPPPPP P PP P
Sbjct: 1489 VAPTPSSPPPPPLPPPPPPAMPS-----------------PPPPPPPAAAPLAAPPEEPA 1531
Query: 574 LPGPAAETVP 583
P P +P
Sbjct: 1532 APSPEDPELP 1541
Score = 48.5 bits (114), Expect = 3e-05
Identities = 24/66 (36%), Positives = 30/66 (45%), Gaps = 2/66 (3%)
Query: 512 NSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPP 571
+ GP P PP P +++ +Q+GP PPPPPPPPPPP P P
Sbjct: 999 SGAGPETPGLGLDPNKPPELPSTVNAEPLGLIQSGP--HQAAPPPPPPPPPPPAPASEPK 1056
Query: 572 PPLPGP 577
L P
Sbjct: 1057 GGLTSP 1062
Score = 47.0 bits (110), Expect = 1e-04
Identities = 32/90 (35%), Positives = 36/90 (40%), Gaps = 21/90 (23%)
Query: 521 ASSGPLPPPPPPLPPSSDTPETVQN-GPVTPPMPPPPPPPPPPPP--------------- 564
A +GP P PP P P GP TP + P PP P
Sbjct: 976 AGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELPSTVNAEPLGLIQSGPH 1035
Query: 565 ---PPPPPPPPPLPGPAAETVPAPPLAPPL 591
PPPPPPPPP P PA+E P L P+
Sbjct: 1036 QAAPPPPPPPPPPPAPASE--PKGGLTSPI 1063
Score = 46.2 bits (108), Expect = 2e-04
Identities = 26/63 (41%), Positives = 29/63 (46%), Gaps = 7/63 (11%)
Query: 515 GPTMGAASSGPLPPPP-----PPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPP 569
GP +SG P P P PP + P TV P+ P PPPPPPPPPP
Sbjct: 991 GPYCPGRASGAGPETPGLGLDPNKPP--ELPSTVNAEPLGLIQSGPHQAAPPPPPPPPPP 1048
Query: 570 PPP 572
P P
Sbjct: 1049 PAP 1051
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/74 (35%), Positives = 31/74 (41%), Gaps = 7/74 (9%)
Query: 537 SDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPG-PAAET--VPAPPL----AP 589
S + + P+ P P PP P P PPPLPG P+A + P PPL P
Sbjct: 1399 SSAISALDDPPLAGPKDTSTPDGPPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPP 1458
Query: 590 PLPSAPPLPGTSSP 603
P P P P P
Sbjct: 1459 PTPPPAPTPQPQPP 1472
Score = 41.6 bits (96), Expect = 0.004
Identities = 46/155 (29%), Positives = 56/155 (36%), Gaps = 44/155 (28%)
Query: 503 SMGSEVVAGNSV-GPT-MGAASS-----GPLPPPPPP--LP--------PSSDTPETVQN 545
S+G E +AG V GP +G A + GP PPPPP LP S+ Q+
Sbjct: 202 SLGFERLAGGGVLGPAGLGPAQTPPYRPGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQS 261
Query: 546 GP----VTPPMPPPPPP----------------PPPPPPPPPPPPPPPLPGPAAETVPAP 585
P + P PPPP P PPPPPPP L + P
Sbjct: 262 SPQLYNFSGAAPGPPPPERALPRQDTVIKHYQRPASAQPPPPPPPAHALQHYLSCGGSYP 321
Query: 586 PL-------APPLPSAPPLPGTSSPTVVFNSGLAA 613
+ PL P PG P+ SG A
Sbjct: 322 SMGHRANLACSPLGGGEPSPGAGEPSKAGPSGATA 356
Score = 40.4 bits (93), Expect = 0.009
Identities = 24/68 (35%), Positives = 27/68 (39%), Gaps = 7/68 (10%)
Query: 510 AGNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPP 569
+G + P SS P P P P PP +TPE T PP P P PP P
Sbjct: 1677 SGQAKNPVSAGGSSAPPPKAPAP-PPKPETPEK------TTSEKPPEQTPETAMPEPPAP 1729
Query: 570 PPPPLPGP 577
P L P
Sbjct: 1730 EKPSLLRP 1737
Score = 40.0 bits (92), Expect = 0.012
Identities = 23/52 (44%), Positives = 25/52 (48%), Gaps = 2/52 (3%)
Query: 526 LPPPPPPLPPSSDTPETVQNGPVTPP--MPPPPPPPPPPPPPPPPPPPPPLP 575
L P P PSS E + G V P + P PP P PP PPPPP LP
Sbjct: 191 LKPSQAPTVPSSLGFERLAGGGVLGPAGLGPAQTPPYRPGPPDPPPPPRHLP 242
Score = 39.7 bits (91), Expect = 0.016
Identities = 24/69 (34%), Positives = 26/69 (37%), Gaps = 1/69 (1%)
Query: 525 PLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPA 584
P PP P+ S V G + P P P PPP P P P P ET
Sbjct: 1666 PWHRPPVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKP-PEQTPETAMP 1724
Query: 585 PPLAPPLPS 593
P AP PS
Sbjct: 1725 EPPAPEKPS 1733
Score = 36.2 bits (82), Expect = 0.17
Identities = 22/77 (28%), Positives = 24/77 (31%), Gaps = 9/77 (11%)
Query: 527 PPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPP 586
PP P + P + PP P PPP P P PP P
Sbjct: 1670 PPVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPE---------QTPE 1720
Query: 587 LAPPLPSAPPLPGTSSP 603
A P P AP P P
Sbjct: 1721 TAMPEPPAPEKPSLLRP 1737
Score = 33.5 bits (75), Expect = 1.1
Identities = 15/44 (34%), Positives = 19/44 (43%)
Query: 563 PPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSPTVV 606
PPP P PPP P T PP P + P P P+++
Sbjct: 1692 PPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPEKPSLL 1735
Score = 32.7 bits (73), Expect = 1.9
Identities = 24/68 (35%), Positives = 28/68 (41%), Gaps = 3/68 (4%)
Query: 546 GPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPP-LPGT--SS 602
GP P PPP PP P P PG A+ P P P+ PP LP T +
Sbjct: 966 GPPEDEGDPKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELPSTVNAE 1025
Query: 603 PTVVFNSG 610
P + SG
Sbjct: 1026 PLGLIQSG 1033
Score = 32.7 bits (73), Expect = 1.9
Identities = 18/63 (28%), Positives = 26/63 (41%)
Query: 495 PVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPP 554
P + SG ++ + + P + A P PP +PPS P TP +P
Sbjct: 1275 PEMKSGFMASFLDFLKSGKRHPPLYQAGLTPPLSPPKSVPPSVPARGLQPQPPATPAVPH 1334
Query: 555 PPP 557
PPP
Sbjct: 1335 PPP 1337
Score = 32.7 bits (73), Expect = 1.9
Identities = 18/54 (33%), Positives = 23/54 (42%), Gaps = 5/54 (9%)
Query: 543 VQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPP 596
+++G PP+ PP PP PP P A P PP P +P PP
Sbjct: 1289 LKSGKRHPPLYQAGLTPPLSPPKSVPPSVP-----ARGLQPQPPATPAVPHPPP 1337
Score = 31.2 bits (69), Expect = 5.6
Identities = 25/77 (32%), Positives = 26/77 (33%), Gaps = 12/77 (15%)
Query: 523 SGPLPPP------PPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPG 576
SG PP PPL P P P P P PP P P PPP G
Sbjct: 1291 SGKRHPPLYQAGLTPPLSPPKSVP------PSVPARGLQPQPPATPAVPHPPPSGAFGLG 1344
Query: 577 PAAETVPAPPLAPPLPS 593
A E + L PS
Sbjct: 1345 GALEAAESEGLGLGCPS 1361
>gi|126090663 zinc finger homeodomain 4 [Homo sapiens]
Length = 3571
Score = 89.7 bits (221), Expect = 1e-17
Identities = 42/80 (52%), Positives = 49/80 (61%), Gaps = 9/80 (11%)
Query: 525 PLPPPPPPLPPSSDTPETVQNGPV-------TPPMPPPPPPPPPPPPPPPPPPPPPLPGP 577
P PPPPPPLPP+ P ++ GPV TP PPP PPPPPPPPPPPPPPPP P P
Sbjct: 1959 PPPPPPPPLPPAPPQPSSM--GPVKIPNTVSTPLQAPPPTPPPPPPPPPPPPPPPPPPPP 2016
Query: 578 AAETVPAPPLAPPLPSAPPL 597
+A P++ LP P +
Sbjct: 2017 SAPPQVQLPVSLDLPLFPSI 2036
Score = 67.8 bits (164), Expect = 5e-11
Identities = 38/85 (44%), Positives = 39/85 (45%), Gaps = 33/85 (38%)
Query: 532 PLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPP--------------------PPPPPPP 571
P+ PSS P TPP PPPPPP PP PP PPP PPP
Sbjct: 1949 PISPSS---------PETPPPPPPPPPLPPAPPQPSSMGPVKIPNTVSTPLQAPPPTPPP 1999
Query: 572 PPLPGPAAETVPAPPLAPPLPSAPP 596
PP P P P PP PP PSAPP
Sbjct: 2000 PPPPPPP----PPPPPPPPPPSAPP 2020
Score = 63.9 bits (154), Expect = 8e-10
Identities = 36/98 (36%), Positives = 50/98 (51%), Gaps = 10/98 (10%)
Query: 547 PVTPPMP--PPPPPPPPPPPPPPPPP----PPPLPGPAAETVPAPPLAPPLPSAPPLPGT 600
P++P P PPPPPPPPP PP PP P P +P + + APP PP P PP P
Sbjct: 1949 PISPSSPETPPPPPPPPPLPPAPPQPSSMGPVKIPNTVSTPLQAPPPTPPPPPPPPPPPP 2008
Query: 601 SSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQ 638
P S A +++ P+ +P+F + ++P Q
Sbjct: 2009 PPPPPPPPS--APPQVQLPV--SLDLPLFPSIMMQPVQ 2042
Score = 62.4 bits (150), Expect = 2e-09
Identities = 35/89 (39%), Positives = 43/89 (48%), Gaps = 28/89 (31%)
Query: 521 ASSGPLPPP---------PPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPP 571
+S GP+ P PPP PP P PPPPPPPPPPPPPPPP P
Sbjct: 1975 SSMGPVKIPNTVSTPLQAPPPTPP---------------PPPPPPPPPPPPPPPPPPSAP 2019
Query: 572 PPLPGPAAETVPAPP--LAPPL--PSAPP 596
P + P + +P P + P+ P+ PP
Sbjct: 2020 PQVQLPVSLDLPLFPSIMMQPVQHPALPP 2048
Score = 44.3 bits (103), Expect = 6e-04
Identities = 20/50 (40%), Positives = 26/50 (52%), Gaps = 5/50 (10%)
Query: 522 SSGPLPPPPP-----PLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPP 566
+S L PP P +S ++ + P P + PPPPPPPPPPPP
Sbjct: 3079 NSNTLTPPGAGMLGFPTSATSSPALSLSSAPTKPLLQTPPPPPPPPPPPP 3128
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/69 (34%), Positives = 28/69 (40%), Gaps = 15/69 (21%)
Query: 527 PPPPPPLPPSSDT-----------PETVQNGPVTPPMPPPPPP----PPPPPPPPPPPPP 571
P P P +S+T P + + P P P PPPPPPPPPPPP
Sbjct: 3070 PSSLPGFPQNSNTLTPPGAGMLGFPTSATSSPALSLSSAPTKPLLQTPPPPPPPPPPPPS 3129
Query: 572 PPLPGPAAE 580
L G E
Sbjct: 3130 SSLSGQQTE 3138
Score = 42.0 bits (97), Expect = 0.003
Identities = 36/115 (31%), Positives = 45/115 (39%), Gaps = 8/115 (6%)
Query: 505 GSEVVAGNSVGP--TMGAASSGPLPPPPPPLPP-SSDTPETVQNGPV-TPPMPPPPPPPP 560
G A N+ P + G+ +S PL P P P P +S PE P + P PP P
Sbjct: 2323 GQTDAAKNAAAPAASSGSGTSTPLIPSPKPEPEKTSPKPEYPAEKPKQSDPSPPSQGTKP 2382
Query: 561 PPPPPPPPPPPPPLPGPAAETVPAPPLAPPL----PSAPPLPGTSSPTVVFNSGL 611
P PP + P PP P L PSA P SSP + + L
Sbjct: 2383 ALPLASTSSDPPQASTAQPQPQPQPPKQPQLIGRPPSASQTPVPSSPLQISMTSL 2437
Score = 37.0 bits (84), Expect = 0.10
Identities = 49/247 (19%), Positives = 85/247 (34%), Gaps = 13/247 (5%)
Query: 349 LDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEK 408
L ++ D + + D+++ L V ++ + +NA + + E +
Sbjct: 2196 LQDFFDTNAYPKDDEIE-----QLSTVLNLPTRVIVVWFQNARQKARKSYENQAETKDNE 2250
Query: 409 LQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTL 468
++ NE + ++ Q K+ +VV D T H ++ K++++ Q +S
Sbjct: 2251 KRELTNERYIRTSNMQYQC----KKCNVVFPRIFDLIT--HQKKQCYKDEDDDAQDESQT 2304
Query: 469 EKKIHELEKQGTIKIQKKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPP 528
E + ++ G D A A+ S GS P + P P
Sbjct: 2305 EDSMDATDQVVYKHCTVSGQTDAA--KNAAAPAASSGSGTSTPLIPSPKPEPEKTSPKPE 2362
Query: 529 PPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLA 588
P P SD Q P+ PP P P P P P P
Sbjct: 2363 YPAEKPKQSDPSPPSQGTKPALPLASTSSDPPQASTAQPQPQPQPPKQPQLIGRPPSASQ 2422
Query: 589 PPLPSAP 595
P+PS+P
Sbjct: 2423 TPVPSSP 2429
Score = 35.8 bits (81), Expect = 0.23
Identities = 24/68 (35%), Positives = 25/68 (36%), Gaps = 21/68 (30%)
Query: 525 PLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPL-PGPAAETVP 583
P PPPPPP PPPPPP PP P PL P + V
Sbjct: 2003 PPPPPPPP--------------------PPPPPPSAPPQVQLPVSLDLPLFPSIMMQPVQ 2042
Query: 584 APPLAPPL 591
P L P L
Sbjct: 2043 HPALPPQL 2050
Score = 35.8 bits (81), Expect = 0.23
Identities = 22/60 (36%), Positives = 27/60 (45%), Gaps = 2/60 (3%)
Query: 525 PLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPA 584
P PPPPPP PP S P+ PV+ +P P P P PP L P + + A
Sbjct: 2005 PPPPPPPPPPPPSAPPQV--QLPVSLDLPLFPSIMMQPVQHPALPPQLALQLPQMDALSA 2062
Score = 32.7 bits (73), Expect = 1.9
Identities = 14/25 (56%), Positives = 15/25 (60%)
Query: 513 SVGPTMGAASSGPLPPPPPPLPPSS 537
S PT + P PPPPPP PPSS
Sbjct: 3106 SSAPTKPLLQTPPPPPPPPPPPPSS 3130
Score = 32.0 bits (71), Expect = 3.3
Identities = 21/77 (27%), Positives = 27/77 (35%), Gaps = 20/77 (25%)
Query: 526 LPPPPPPLPPSSDTPETVQNGPVTPPMPPPP--------------------PPPPPPPPP 565
LP PP L P + P ++ P PP P P
Sbjct: 3056 LPGLPPVLLPGMNGPSSLPGFPQNSNTLTPPGAGMLGFPTSATSSPALSLSSAPTKPLLQ 3115
Query: 566 PPPPPPPPLPGPAAETV 582
PPPPPPP P P + ++
Sbjct: 3116 TPPPPPPPPPPPPSSSL 3132
Score = 31.2 bits (69), Expect = 5.6
Identities = 26/82 (31%), Positives = 28/82 (34%), Gaps = 6/82 (7%)
Query: 516 PTMGAASSGPLPPPP---PPLP---PSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPP 569
P S P PP P LP SSD P+ P P PP P PP
Sbjct: 2364 PAEKPKQSDPSPPSQGTKPALPLASTSSDPPQASTAQPQPQPQPPKQPQLIGRPPSASQT 2423
Query: 570 PPPPLPGPAAETVPAPPLAPPL 591
P P P + T L P L
Sbjct: 2424 PVPSSPLQISMTSLQNSLPPQL 2445
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 88.6 bits (218), Expect = 3e-17
Identities = 51/100 (51%), Positives = 54/100 (54%), Gaps = 22/100 (22%)
Query: 505 GSEVVAGNSV-GPTMGAASSGPLPPPP--PPLPPSSDTPETVQNGPVTPPMPPPPPPPPP 561
G+ VA SV PT+ PLPPPP PPLPP P P P P PPP PPP
Sbjct: 665 GAAAVAAPSVLAPTL------PLPPPPGFPPLPPPPPPP------PPQPGFPMPPPLPPP 712
Query: 562 PPPPPP-----PPPPPPLPGPAAETVPAPPLAPPLPSAPP 596
PPPPPP PPPPLP P VP PP+ PPLP PP
Sbjct: 713 PPPPPPAHPAVTVPPPPLPAPPG--VPPPPILPPLPPFPP 750
Score = 79.3 bits (194), Expect = 2e-14
Identities = 47/96 (48%), Positives = 51/96 (53%), Gaps = 22/96 (22%)
Query: 514 VGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPP----PPPPPP 569
V P A ++ + P PLPP P PP+PPPPPPPPP P PPP PP
Sbjct: 662 VTPGAAAVAAPSVLAPTLPLPPP----------PGFPPLPPPPPPPPPQPGFPMPPPLPP 711
Query: 570 PPPPLPGPA--AETVPAPPL-----APPLPSAPPLP 598
PPPP P PA A TVP PPL PP P PPLP
Sbjct: 712 PPPP-PPPAHPAVTVPPPPLPAPPGVPPPPILPPLP 746
Score = 56.2 bits (134), Expect = 2e-07
Identities = 36/90 (40%), Positives = 41/90 (45%), Gaps = 9/90 (10%)
Query: 511 GNSVGPTMGAASSGPL----PPPPPPLPPSSDTPETV----QNGPVTPPMPPPPPPPPPP 562
G V P GAA L P P+ PS+ P TV +N + P PPP PP PPP
Sbjct: 1491 GPLVRPPAGAALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAP-PPPLPPQPPP 1549
Query: 563 PPPPPPPPPPPLPGPAAETVPAPPLAPPLP 592
PPPPPP P LP + PP P
Sbjct: 1550 PPPPPPVEPTKLPFKELDNQWPSEAIPPGP 1579
Score = 55.8 bits (133), Expect = 2e-07
Identities = 66/250 (26%), Positives = 94/250 (37%), Gaps = 32/250 (12%)
Query: 377 DVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDV 436
D L +A K+ E + EE +S ++ K + T + S+ E E +
Sbjct: 1078 DEDTALSEASEKD---EGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSED 1134
Query: 437 VREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELE-KQGTIKIQKKG---DGDI- 491
E+ + +MV E+ A E+ E G + G + DI
Sbjct: 1135 EEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIE 1194
Query: 492 --AILP-----VVASGTLSMGSEVVAGNSVGPTM-GAASSGPL---PPPP-------PPL 533
A+ P ++ L +G E A + P G + G + P PP PPL
Sbjct: 1195 TEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPL 1254
Query: 534 PPSSDTPETVQNGPVTPPMPP----PPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAP 589
P ++ P P M P PP PPP PP PP PPP P + +VP PLA
Sbjct: 1255 SPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAE 1314
Query: 590 PLPSAPPLPG 599
P P PG
Sbjct: 1315 DHP--PHTPG 1322
Score = 54.3 bits (129), Expect = 6e-07
Identities = 34/83 (40%), Positives = 41/83 (49%), Gaps = 12/83 (14%)
Query: 529 PPPPLPPSSDTPETVQNGP----VTPP--MPPPPPPPPPPPPPPPPPPPPPLPGPAAETV 582
P P+ S+D P+ + P V P + P P PPPP PP PPPPPP P
Sbjct: 647 PSAPIT-SADCPKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPP-----PQ 700
Query: 583 PAPPLAPPLPSAPPLPGTSSPTV 605
P P+ PPLP PP P + P V
Sbjct: 701 PGFPMPPPLPPPPPPPPPAHPAV 723
Score = 45.1 bits (105), Expect = 4e-04
Identities = 32/93 (34%), Positives = 37/93 (39%), Gaps = 16/93 (17%)
Query: 525 PLPPPPPPLPPSSDT-PETVQ-NGPVTPPMPPPPPPPPPPPP--------------PPPP 568
PLPPP PP PPS PET + P PP P PP P P P
Sbjct: 1281 PLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTETVPATP 1340
Query: 569 PPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTS 601
PPL G ++ + P P P + P P S
Sbjct: 1341 GGEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPS 1373
Score = 41.2 bits (95), Expect = 0.005
Identities = 26/89 (29%), Positives = 33/89 (37%), Gaps = 26/89 (29%)
Query: 529 PPPPLPPSS-------DTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPP--------- 572
PPPP P++ D+ E + P PP+PP P P PP PPPP
Sbjct: 408 PPPPEEPTATAAFGARDSGE-FRRAPAPPPLPPAEPLAKEKPGTPPGPPPPDTNSMELGG 466
Query: 573 ---------PLPGPAAETVPAPPLAPPLP 592
P P T+ + P P P
Sbjct: 467 RPTFGWSPEPCDSPGTPTLESSPAGPEKP 495
Score = 40.8 bits (94), Expect = 0.007
Identities = 34/122 (27%), Positives = 39/122 (31%), Gaps = 17/122 (13%)
Query: 499 SGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPP 558
S L G+ G S GP A P PP+ TP +P P
Sbjct: 349 SSDLPFGAVGGTGGSSGPPFKAQPQDSATFAHTP-PPAQATPAPGFKSAFSPYQTPVAHF 407
Query: 559 PPPPPPPP----------------PPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSS 602
PPPP P P PPP P P A+ P P PP P +
Sbjct: 408 PPPPEEPTATAAFGARDSGEFRRAPAPPPLPPAEPLAKEKPGTPPGPPPPDTNSMELGGR 467
Query: 603 PT 604
PT
Sbjct: 468 PT 469
Score = 40.0 bits (92), Expect = 0.012
Identities = 30/77 (38%), Positives = 34/77 (44%), Gaps = 6/77 (7%)
Query: 523 SGPLPPPPPPLPPSSDTPETVQNGPVTPP--MPPPPPPPPPPPPPPPPPPPPPLPGPAAE 580
SGPL P PLP ++GP+ P + P P P P P P P L A
Sbjct: 1397 SGPLLLPVCPLPTGR---RDERSGPLASPVLLETGLPLPLPLPLPLPLALPAVLRAQARA 1453
Query: 581 TVPAPPLAP-PLPSAPP 596
P PPL P PL S PP
Sbjct: 1454 PTPLPPLLPAPLASCPP 1470
Score = 39.3 bits (90), Expect = 0.021
Identities = 36/150 (24%), Positives = 43/150 (28%), Gaps = 50/150 (33%)
Query: 520 AASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPP-----------PP----------- 557
A + P P PP P + P ++ P P PP PP
Sbjct: 1449 AQARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGPLVRPPAGAALGRELLL 1508
Query: 558 ----------------------------PPPPPPPPPPPPPPPPLPGPAAETVPAPPLAP 589
P PPPP PP PPPPPP P +P L
Sbjct: 1509 LPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPPPVEPTKLPFKELDN 1568
Query: 590 PLPSAPPLPGTSSPTVVFNSGLAAVKIKKP 619
PS PG V + K + P
Sbjct: 1569 QWPSEAIPPGPRGRDEVTEEYMELAKSRGP 1598
Score = 34.7 bits (78), Expect = 0.51
Identities = 52/213 (24%), Positives = 64/213 (30%), Gaps = 80/213 (37%)
Query: 467 TLEKKIHELEKQGTIKIQ--KKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSG 524
+L+ +I L K+ K+ ++ D D L + S S S++ G G
Sbjct: 498 SLDSRIEMLLKEQRTKLLFLREPDSDTE-LQMEGSPISSSSSQLSPLAPFGTNSQPGFRG 556
Query: 525 PLPPP------------PPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPP--------- 563
P PP P PLP SD E + G P PPP P PP P
Sbjct: 557 PTPPSSRPSSTGLEDISPTPLP-DSDEDEELDLG--LGPRPPPEPGPPDPAGLLSQTAEV 613
Query: 564 ---------------------------------PPPP------PPPPPPLPGPAAETVPA 584
P P P P PG AA P+
Sbjct: 614 ALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAAAVAAPS 673
Query: 585 --------------PPLAPPLPSAPPLPGTSSP 603
PPL PP P PP PG P
Sbjct: 674 VLAPTLPLPPPPGFPPLPPPPPPPPPQPGFPMP 706
Score = 32.7 bits (73), Expect = 1.9
Identities = 32/109 (29%), Positives = 39/109 (35%), Gaps = 20/109 (18%)
Query: 525 PLPPPPP-PLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAE-TV 582
PLP P P PLP + Q TP P P P PPP P P P + ++
Sbjct: 1430 PLPLPLPLPLPLALPAVLRAQARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLSL 1489
Query: 583 PAPPLAPPL--------------PSAPPLPGTSSPTVVF----NSGLAA 613
P + PP P P P T P V N+G+ A
Sbjct: 1490 DGPLVRPPAGAALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPA 1538
>gi|14249316 hypothetical protein LOC84800 [Homo sapiens]
Length = 234
Score = 87.0 bits (214), Expect = 9e-17
Identities = 46/135 (34%), Positives = 76/135 (56%), Gaps = 2/135 (1%)
Query: 224 CIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVR-GGHEI 282
C+ C+RA+MN + G ++S+ V +++ +L+ N K V ELLAA+C+ GH +
Sbjct: 101 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVL 160
Query: 283 ILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQY 342
L A D++K VC ++ RF +M D N+ ++V + IN V+ ED+ R L+
Sbjct: 161 TLDALDHYKTVCSQQYRFSIVMNELSGSD-NVPYVVTLLSVINAVILGPEDLRARTQLRN 219
Query: 343 EFTKLGLDEYLDKLK 357
EF L L + L +L+
Sbjct: 220 EFIGLQLLDVLARLR 234
>gi|11386183 WAS protein family, member 2 [Homo sapiens]
Length = 498
Score = 79.7 bits (195), Expect = 1e-14
Identities = 51/133 (38%), Positives = 56/133 (42%), Gaps = 37/133 (27%)
Query: 515 GPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPP------PPPP----- 563
GP + S PPP PPL +P + G PP PPPPPPP PPPP
Sbjct: 288 GPKRSSVVSPSHPPPAPPL----GSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGS 343
Query: 564 ---PPPP-------------PPPPPPLPGPAAETVPAPPL------APPLPSAPPLPGTS 601
PPPP PPPPPP P T+P PPL APP P PP PG
Sbjct: 344 PGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPP 403
Query: 602 SPTVVFNSGLAAV 614
P G A+
Sbjct: 404 PPPFTGADGQPAI 416
Score = 73.9 bits (180), Expect = 8e-13
Identities = 41/106 (38%), Positives = 44/106 (41%), Gaps = 28/106 (26%)
Query: 516 PTMGAASSGPLPPPPPP-LPPSSDTPETVQNGPVTPPMPPPPP----------------- 557
P +G S G PPP PP PP D PP PPPPP
Sbjct: 337 PPVGFGSPGTPPPPSPPSFPPHPDF--------AAPPPPPPPPAADYPTLPPPPLSQPTG 388
Query: 558 --PPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTS 601
PPPPPPPPPP PPPPP G + PPL+ LP S
Sbjct: 389 GAPPPPPPPPPPGPPPPPFTGADGQPAIPPPLSDTTKPKSSLPAVS 434
Score = 72.8 bits (177), Expect = 2e-12
Identities = 48/128 (37%), Positives = 52/128 (40%), Gaps = 43/128 (33%)
Query: 511 GNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNG-PVTPP--------------MPPP 555
G+ GP G A PPPPPP+ P V G P TPP PPP
Sbjct: 307 GSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPP 366
Query: 556 PPPPP--------------------PPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAP 595
PPPPP PPPPPPPPP PPP P A+ PA P P
Sbjct: 367 PPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAIP--------P 418
Query: 596 PLPGTSSP 603
PL T+ P
Sbjct: 419 PLSDTTKP 426
Score = 68.9 bits (167), Expect = 2e-11
Identities = 60/216 (27%), Positives = 83/216 (38%), Gaps = 49/216 (22%)
Query: 439 EIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIH------ELEKQGTIKIQKK---GDG 489
++ +D + RK KEK++ R + +KI E K G ++ K G
Sbjct: 163 KMLQDTKDIMKEKRKHRKEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTS 222
Query: 490 DIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPP------PPPPLP--------- 534
V +G++ V A + P ++S P P PPPP
Sbjct: 223 GYPPTLVYQNGSIGCVENVDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQR 282
Query: 535 ------PSSDTPETVQNGPVTPPMPPPP-------PPPPPPPPPPP----PPPPPPL--P 575
P + + + P PP+ PP PPP PPPPPPP PPPPPP+
Sbjct: 283 GSGLAGPKRSSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFG 342
Query: 576 GPAAETVPAPPLAPPLPS------APPLPGTSSPTV 605
P P+PP PP P PP P PT+
Sbjct: 343 SPGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPTL 378
Score = 67.0 bits (162), Expect = 9e-11
Identities = 33/74 (44%), Positives = 42/74 (56%), Gaps = 8/74 (10%)
Query: 528 PPPPPLPPSSDTPETVQNGPVTPPMP-PPPPPPPPPPPPPPPPP------PPPLPGPAAE 580
PPPPP PP++D P T+ P++ P PPPPPPPPPP PPPPP P +P P ++
Sbjct: 364 PPPPPPPPAADYP-TLPPPPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAIPPPLSD 422
Query: 581 TVPAPPLAPPLPSA 594
T P + A
Sbjct: 423 TTKPKSSLPAVSDA 436
>gi|56118221 amyloid beta (A4) precursor protein-binding, family B,
member 1 interacting protein [Homo sapiens]
Length = 666
Score = 78.6 bits (192), Expect = 3e-14
Identities = 49/126 (38%), Positives = 56/126 (44%), Gaps = 37/126 (29%)
Query: 511 GNSVGPTMGAASSGPLP--PPPPPLPPSSDTPETVQNGPVTP-----------PMPP--- 554
GN P + A P PPPPP+ SSDT P TP P PP
Sbjct: 498 GNHHDPAVPRAPHAPKSSLPPPPPVRRSSDT----SGSPATPLKAKGTGGGGLPAPPDDF 553
Query: 555 -PPPPPPPP------PPPPP----------PPPPPPLPGPAAETVPAPPLAPPLPSAPPL 597
PPPPPPPP PPPPP PPPPP G A +P PP PP P+ P+
Sbjct: 554 LPPPPPPPPLDDPELPPPPPDFMEPPPDFVPPPPPSYAGIAGSELPPPPPPPPAPAPAPV 613
Query: 598 PGTSSP 603
P ++ P
Sbjct: 614 PDSARP 619
Score = 72.8 bits (177), Expect = 2e-12
Identities = 43/111 (38%), Positives = 48/111 (43%), Gaps = 24/111 (21%)
Query: 506 SEVVAGNSVGPTMGAASSG---PLPP----PPPPLPPSSDTPETVQNGPVTPP--MPPPP 556
S +G+ P + G P PP PPPP PP D PE P PP M PPP
Sbjct: 525 SSDTSGSPATPLKAKGTGGGGLPAPPDDFLPPPPPPPPLDDPEL----PPPPPDFMEPPP 580
Query: 557 PPPPPPP-----------PPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPP 596
PPPP PPPPPPPP P P P ++ PP P PP
Sbjct: 581 DFVPPPPPSYAGIAGSELPPPPPPPPAPAPAPVPDSARPPPAVAKRPPVPP 631
Score = 39.7 bits (91), Expect = 0.016
Identities = 22/59 (37%), Positives = 25/59 (42%), Gaps = 9/59 (15%)
Query: 520 AASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPA 578
A S P PPPPPP P + P++ PPP PP PP P PG A
Sbjct: 594 AGSELPPPPPPPPAPAPAPVPDS---------ARPPPAVAKRPPVPPKRQENPGHPGGA 643
Score = 32.7 bits (73), Expect = 1.9
Identities = 13/21 (61%), Positives = 13/21 (61%)
Query: 554 PPPPPPPPPPPPPPPPPPPPL 574
PPPP P P PPPPP PL
Sbjct: 129 PPPPADPVLDLPLPPPPPEPL 149
Score = 32.0 bits (71), Expect = 3.3
Identities = 34/127 (26%), Positives = 49/127 (38%), Gaps = 31/127 (24%)
Query: 441 YKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKG----DGDIAILPV 496
+KD N ++ L E ++ + L I E E Q TI+ QK+ ++
Sbjct: 49 FKDLNESLNAL-----EDQDLDALMADLVADISEAE-QRTIQAQKESLQNQHHSASLQAS 102
Query: 497 VASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPP 556
+ SG S+G G +V T + LPPPP P + P
Sbjct: 103 IFSGAASLGY----GTNVAATGISQYEDDLPPPP-----------------ADPVLDLPL 141
Query: 557 PPPPPPP 563
PPPPP P
Sbjct: 142 PPPPPEP 148
Score = 32.0 bits (71), Expect = 3.3
Identities = 12/21 (57%), Positives = 13/21 (61%)
Query: 552 MPPPPPPPPPPPPPPPPPPPP 572
+PPPP P P PPPPP P
Sbjct: 128 LPPPPADPVLDLPLPPPPPEP 148
Score = 30.4 bits (67), Expect = 9.5
Identities = 12/20 (60%), Positives = 12/20 (60%)
Query: 556 PPPPPPPPPPPPPPPPPPLP 575
PPPP P P PPPPP P
Sbjct: 129 PPPPADPVLDLPLPPPPPEP 148
>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
sapiens]
Length = 505
Score = 77.4 bits (189), Expect = 7e-14
Identities = 51/143 (35%), Positives = 58/143 (40%), Gaps = 35/143 (24%)
Query: 516 PTMGAASSGPLPPPPPPL------PPSSDT---PETVQNGPVTPPMPPPP-------PPP 559
P + GP PPPPPP PP+ P P P PPPP PPP
Sbjct: 278 PPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPP 337
Query: 560 PP----PPPPP---------PPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSS---- 602
PP PPPPP PPPPPP + G P PP PP P PP PG S
Sbjct: 338 PPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPPPPPPGPPPPPGLPSDGDH 397
Query: 603 --PTVVFNSGLAAVKIKKPIKTK 623
PT N +I++ + K
Sbjct: 398 QVPTTAGNKAALLDQIREGAQLK 420
Score = 65.5 bits (158), Expect = 3e-10
Identities = 40/94 (42%), Positives = 42/94 (44%), Gaps = 29/94 (30%)
Query: 527 PPPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPP------PPPPP-------PPP 569
PPPPPP + GP PP PPPP PPPPP PPPPP PPP
Sbjct: 277 PPPPPPS----------RGGP--PPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPP 324
Query: 570 PPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSP 603
PPP P A P + PP P A P S P
Sbjct: 325 PPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGP 358
Score = 58.2 bits (139), Expect = 4e-08
Identities = 31/59 (52%), Positives = 34/59 (57%), Gaps = 10/59 (16%)
Query: 554 PPPPPP----PPPPPPPP---PPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSPTV 605
PPPPPP PPPPPPPP PPPPP G A P PP + +APP P S P+V
Sbjct: 277 PPPPPPSRGGPPPPPPPPHNSGPPPPPARGRGA---PPPPPSRAPTAAPPPPPPSRPSV 332
>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
sapiens]
Length = 483
Score = 76.6 bits (187), Expect = 1e-13
Identities = 44/119 (36%), Positives = 50/119 (42%), Gaps = 20/119 (16%)
Query: 505 GSEVVAGNSVGPTMGAASSGPLPPP--------PPPLPPSSDTPETVQNGPVTPPMPPPP 556
G VAG G G+ + P P PP P +T E PP P P
Sbjct: 113 GQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVP 172
Query: 557 PPPPPPPPPPPPPPPPPLPGPAAETVP------------APPLAPPLPSAPPLPGTSSP 603
PPPP PPPPPPP PPPLP + P P +APP+P APP P P
Sbjct: 173 APPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPP 231
Score = 73.2 bits (178), Expect = 1e-12
Identities = 40/101 (39%), Positives = 48/101 (47%), Gaps = 20/101 (19%)
Query: 516 PTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPP-------MPPPPPPPPPPPPPPPP 568
P + A PPPPPPLPP + ++ V+PP +P PP P PPPPPP
Sbjct: 169 PNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPP 228
Query: 569 PP---PPPLP----------GPAAETVPAPPLAPPLPSAPP 596
PP PPPLP P + PP+ PPLP PP
Sbjct: 229 PPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPP 269
Score = 62.4 bits (150), Expect = 2e-09
Identities = 39/117 (33%), Positives = 48/117 (41%), Gaps = 19/117 (16%)
Query: 506 SEVVAGNSVGPTMGAASSGPLPPPPPPLPPSS-----DTPETVQNGPVTPPMPPPPPPPP 560
+ V++ +V P + P+PPP P LPP P + PP PPPP PP
Sbjct: 240 ASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPY 299
Query: 561 PPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPS--------------APPLPGTSSP 603
P P PPLPG + + PPL P PS APP P S P
Sbjct: 300 ASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQP 356
Score = 55.8 bits (133), Expect = 2e-07
Identities = 22/34 (64%), Positives = 25/34 (73%), Gaps = 3/34 (8%)
Query: 551 PMPPPPPPPPPPPPPP---PPPPPPPLPGPAAET 581
P+PPPPPPP PPPPPP PPPPPP P + +T
Sbjct: 2 PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDT 35
Score = 53.1 bits (126), Expect = 1e-06
Identities = 22/33 (66%), Positives = 22/33 (66%), Gaps = 3/33 (9%)
Query: 552 MPPPPPPPPPPPPPPPP---PPPPPLPGPAAET 581
MP PPPPPPP PPPPPP PPPPP P T
Sbjct: 1 MPVPPPPPPPLPPPPPPLGAPPPPPPSAPPVST 33
Score = 52.4 bits (124), Expect = 2e-06
Identities = 23/42 (54%), Positives = 25/42 (59%), Gaps = 2/42 (4%)
Query: 547 PVTPPMPPPPPPPPPP--PPPPPPPPPPPLPGPAAETVPAPP 586
PV PP PPP PPPPPP PPPPPP PP+ + A P
Sbjct: 2 PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADP 43
Score = 52.0 bits (123), Expect = 3e-06
Identities = 22/34 (64%), Positives = 23/34 (67%), Gaps = 4/34 (11%)
Query: 558 PPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPL 591
P PPPPPPP PPPPPPL P P PP APP+
Sbjct: 2 PVPPPPPPPLPPPPPPLGAPP----PPPPSAPPV 31
Score = 50.8 bits (120), Expect = 7e-06
Identities = 22/47 (46%), Positives = 24/47 (51%), Gaps = 18/47 (38%)
Query: 525 PLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPP 571
P+PPPPP PP+PPPPPP PPPPPP PP
Sbjct: 2 PVPPPPP------------------PPLPPPPPPLGAPPPPPPSAPP 30
Score = 50.4 bits (119), Expect = 9e-06
Identities = 21/40 (52%), Positives = 23/40 (57%)
Query: 551 PMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPP 590
P PPPPP PPPPPP PPPPPP P + + A P
Sbjct: 4 PPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADP 43
Score = 43.9 bits (102), Expect = 8e-04
Identities = 22/38 (57%), Positives = 25/38 (65%), Gaps = 3/38 (7%)
Query: 565 PPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSS 602
P PPPPPPPLP P + APP PP PSAPP+ +S
Sbjct: 2 PVPPPPPPPLP-PPPPPLGAPP--PPPPSAPPVSTDTS 36
Score = 40.8 bits (94), Expect = 0.007
Identities = 26/93 (27%), Positives = 28/93 (30%), Gaps = 18/93 (19%)
Query: 516 PTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPP--------------- 560
P G SS PPP PP PS P P P PP P
Sbjct: 312 PLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGG 371
Query: 561 ---PPPPPPPPPPPPPLPGPAAETVPAPPLAPP 590
PPP PP P L + + P P
Sbjct: 372 KLNPPPAPPARSPTTELSSKSQQATAWTPTQQP 404
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,141,339
Number of Sequences: 37866
Number of extensions: 3175558
Number of successful extensions: 173530
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1981
Number of HSP's successfully gapped in prelim test: 1412
Number of HSP's that attempted gapping in prelim test: 40098
Number of HSP's gapped (non-prelim): 45927
length of query: 1092
length of database: 18,247,518
effective HSP length: 113
effective length of query: 979
effective length of database: 13,968,660
effective search space: 13675318140
effective search space used: 13675318140
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.