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Search of human proteins with 4885341
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4885341 G protein-coupled receptor 6 [Homo sapiens]
(362 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4885341 G protein-coupled receptor 6 [Homo sapiens] 715 0.0
gi|4885325 G protein-coupled receptor 3 [Homo sapiens] 390 e-108
gi|4885295 G protein-coupled receptor 12 [Homo sapiens] 384 e-107
gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens] 127 2e-29
gi|134244587 endothelial differentiation, sphingolipid G-protein... 126 3e-29
gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens] 119 6e-27
gi|13540517 endothelial differentiation, sphingolipid G-protein-... 116 3e-26
gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens] 114 1e-25
gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens] 114 2e-25
gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens] 106 3e-23
gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens] 106 3e-23
gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens] 103 2e-22
gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens] 103 2e-22
gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens] 103 2e-22
gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens] 103 2e-22
gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens] 103 2e-22
gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens] 103 2e-22
gi|4502929 cannabinoid receptor 2 (macrophage) [Homo sapiens] 101 1e-21
gi|4501951 adenosine A2b receptor [Homo sapiens] 100 3e-21
gi|193083134 melanocortin 1 receptor [Homo sapiens] 98 1e-20
gi|170671732 melanocortin 3 receptor [Homo sapiens] 98 1e-20
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 97 2e-20
gi|119508433 melanocortin 4 receptor [Homo sapiens] 96 4e-20
gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens] 96 5e-20
gi|4503459 sphingosine-1-phosphate receptor 4 precursor [Homo sa... 90 4e-18
gi|5174535 melanocortin 5 receptor [Homo sapiens] 89 6e-18
gi|30425400 G protein-coupled receptor 119 [Homo sapiens] 87 2e-17
gi|115305569 adenosine A1 receptor [Homo sapiens] 84 2e-16
gi|4501947 adenosine A1 receptor [Homo sapiens] 84 2e-16
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 84 3e-16
>gi|4885341 G protein-coupled receptor 6 [Homo sapiens]
Length = 362
Score = 715 bits (1846), Expect = 0.0
Identities = 362/362 (100%), Positives = 362/362 (100%)
Query: 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQL 60
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQL
Sbjct: 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQL 60
Query: 61 SAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLL 120
SAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLL
Sbjct: 61 SAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLL 120
Query: 121 AGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRR 180
AGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRR
Sbjct: 121 AGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRR 180
Query: 181 TLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGI 240
TLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGI
Sbjct: 181 TLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGI 240
Query: 241 MLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCV 300
MLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCV
Sbjct: 241 MLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCV 300
Query: 301 VGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPS 360
VGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPS
Sbjct: 301 VGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPS 360
Query: 361 EV 362
EV
Sbjct: 361 EV 362
>gi|4885325 G protein-coupled receptor 3 [Homo sapiens]
Length = 330
Score = 390 bits (1001), Expect = e-108
Identities = 193/329 (58%), Positives = 239/329 (72%), Gaps = 3/329 (0%)
Query: 36 WGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNP--WDVLLCVSGTVIAGENALV 93
WG + A + G N ++ S + GP G P +P WDV+LC+SGT+++ ENALV
Sbjct: 3 WGAGSPLAWLSAGSGNVNVS-SVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSCENALV 61
Query: 94 VALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFA 153
VA+I TPA R PMF+LVGSLA ADLLAG GL+LHF + + S +SL+ VG L +F
Sbjct: 62 VAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSAEMSLVLVGVLAMAFT 121
Query: 154 ASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAER 213
AS+ SLLAITVDRYLSLYNALTYYS T+ +++LA W +LGLGLLPVL WNCL
Sbjct: 122 ASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDGL 181
Query: 214 AACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAA 273
C VV PL+++H+ +L+ AFFMVFGIML LY +IC++V RHA QIALQ+H L H A
Sbjct: 182 TTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVA 241
Query: 274 TRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRN 333
TRKG+ TLAVVLG F A WLPF +YC++G P +YTY TLLPATYNSMINPIIYAFRN
Sbjct: 242 TRKGIATLAVVLGAFAACWLPFTVYCLLGDAHSPPLYTYLTLLPATYNSMINPIIYAFRN 301
Query: 334 QEIQRALWLLLCGCFQSKVPFRSRSPSEV 362
Q++Q+ LW + C C SK+PFRSRSPS+V
Sbjct: 302 QDVQKVLWAVCCCCSSSKIPFRSRSPSDV 330
>gi|4885295 G protein-coupled receptor 12 [Homo sapiens]
Length = 334
Score = 384 bits (985), Expect = e-107
Identities = 187/319 (58%), Positives = 241/319 (75%), Gaps = 1/319 (0%)
Query: 44 LGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPAL 103
L A N S +SS++ A P L VNPWD++LC SGT+I+ ENA+VV +I P+L
Sbjct: 17 LDAAAAENISAAVSSRVPAVEPEPEL-VVNPWDIVLCTSGTLISCENAIVVLIIFHNPSL 75
Query: 104 RTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAIT 163
R PMF+L+GSLA ADLLAG GLI +FVF YL+ SE L+T+G +VASF+ASV SLLAIT
Sbjct: 76 RAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLIVASFSASVCSLLAIT 135
Query: 164 VDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLA 223
VDRYLSLY ALTY+S RT+ +++L W S+ LGLLPV+GWNCL + + CSVVRPL
Sbjct: 136 VDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLT 195
Query: 224 RSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAV 283
+++ A+LS +F +F +ML LY++IC++V RHAHQIALQ H LA H TRKGV TLA+
Sbjct: 196 KNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAI 255
Query: 284 VLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLL 343
+LGTF A W+PF +Y ++ + P++YTYATLLPATYNS+INP+IYAFRNQEIQ+AL L+
Sbjct: 256 ILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLI 315
Query: 344 LCGCFQSKVPFRSRSPSEV 362
CGC S + R+RSPS+V
Sbjct: 316 CCGCIPSSLAQRARSPSDV 334
>gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens]
Length = 351
Score = 127 bits (319), Expect = 2e-29
Identities = 98/286 (34%), Positives = 148/286 (51%), Gaps = 18/286 (6%)
Query: 74 PWDVLLCVSGTVIAG----ENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHF 129
P DV++ G ++ N LV+A IAS P++ L+G+LA ADL AG L
Sbjct: 30 PKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAY-LFL 88
Query: 130 VFQYLVPSETVSL----LTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGV 185
+F + +SL L G L S ASV++LLAI V+R+ S+ A+ +SR V
Sbjct: 89 MFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVM-AVQLHSRLPRGRV 147
Query: 186 HLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRP-LARSHVALLSAAFFMVFGIMLHL 244
+L+ W +LGLGLLP W+CL CS + P L+RS++A+ + + +VF +M+ +
Sbjct: 148 VMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAV 207
Query: 245 YVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVG-- 302
Y RI V R ++A C P + T V T+ ++LG F W P + ++
Sbjct: 208 YTRIFFYVRRRVQRMAEHVSC-HPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGL 266
Query: 303 ---SHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLC 345
S AV Y LL A NS++N +Y+ R+ E++R LLC
Sbjct: 267 GCESCNVLAVEKYFLLL-AEANSLVNAAVYSCRDAEMRRTFRRLLC 311
>gi|134244587 endothelial differentiation, sphingolipid
G-protein-coupled receptor, 5 [Homo sapiens]
Length = 353
Score = 126 bits (317), Expect = 3e-29
Identities = 97/277 (35%), Positives = 146/277 (52%), Gaps = 35/277 (12%)
Query: 77 VLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVP 136
V+LC + I EN LV+ +A + M++ +G+LA +DLLAG + + + L
Sbjct: 41 VILCCA---IVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTL---LSG 94
Query: 137 SETVSLLTV------GFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLA 190
S T+ L V G + +ASV SLLAI ++R++++ Y S ++ + LL+
Sbjct: 95 SVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRML-LLIG 153
Query: 191 ATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGI-MLHLYVRI- 248
A+W +SL LG LP+LGWNCL ACS V PL H L F + + ++ LYVRI
Sbjct: 154 ASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIY 213
Query: 249 CQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLP-FAIY-----CVVG 302
C V HA +A P A K T+ +VLG F WLP F+I C V
Sbjct: 214 CVVRSSHAD--------MAAPQTLALLK---TVTIVLGVFIVCWLPAFSILLLDYACPV- 261
Query: 303 SHEDPAVY-TYATLLPATYNSMINPIIYAFRNQEIQR 338
H P +Y + +T NS++NP+IY +R+++++R
Sbjct: 262 -HSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRR 297
>gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens]
Length = 353
Score = 119 bits (297), Expect = 6e-27
Identities = 92/308 (29%), Positives = 156/308 (50%), Gaps = 34/308 (11%)
Query: 77 VLLCVSGTV----IAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQ 132
++LCV GT I N+LV+A + P + L+ +LA AD AG + +F
Sbjct: 32 IVLCV-GTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVF-LMFN 89
Query: 133 YLVPSETVSL----LTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLL 188
S+T+++ L G L +S AS+++LL I V+R++S+ + +S T V LL
Sbjct: 90 TGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMR-MRVHSNLTKKRVTLL 148
Query: 189 LAATWTVSLGLGLLPVLGWNCLAERAACSVVRPL-ARSHVALLSAAFFMVFGIMLHLYVR 247
+ W +++ +G +P LGWNCL +ACS + P+ +RS++ + + M F IM+ +Y+R
Sbjct: 149 ILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLR 208
Query: 248 ICQVVWRHAHQIALQQHCLAPPHLAAT-------RKGVGTLAVVLGTFGASWLPFAIYCV 300
I V R + ++ PH + + K + T+ VLG F W P + +
Sbjct: 209 IYVYVKRKTNVLS--------PHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLL 260
Query: 301 VGSHEDPAVYTYAT----LLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFR- 355
+ LL A NS++NPIIY+++++++ + ++C CF + P R
Sbjct: 261 LDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMIC-CFSQENPERR 319
Query: 356 -SRSPSEV 362
SR PS V
Sbjct: 320 PSRIPSTV 327
>gi|13540517 endothelial differentiation, sphingolipid
G-protein-coupled receptor, 8 [Homo sapiens]
Length = 398
Score = 116 bits (291), Expect = 3e-26
Identities = 100/294 (34%), Positives = 138/294 (46%), Gaps = 34/294 (11%)
Query: 76 DVLLCVSGTV-IAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQ-- 132
D ++C++ I EN V+ ++ P PMF+L+GSL +DLLAG + +
Sbjct: 39 DAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGP 98
Query: 133 -YLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYN---ALTYYSRRTLLGVHLL 188
L S + G + + ASV SLLAI ++R L++ A RTL +
Sbjct: 99 LTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLA----M 154
Query: 189 LAATWTVSLGLGLLPVLGWNCLAERAACSVVRPL-ARSHVALLSAAFFMVFGIMLHLYVR 247
AA W VSL LGLLP LGWNCL ACS V PL A+++V AF + + LY R
Sbjct: 155 AAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYAR 214
Query: 248 ICQVVWRHAHQIALQQHCLAPPHLAATRKG-----VGTLAVVLGTFGASWLPF------- 295
I V +A ++ + A RK + TL+VVL F A W P
Sbjct: 215 IYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLD 274
Query: 296 ----AIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLC 345
A C V DP L A NS++NPIIY N++++ AL L+C
Sbjct: 275 VACPARTCPVLLQADP------FLGLAMANSLLNPIIYTLTNRDLRHALLRLVC 322
>gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens]
Length = 382
Score = 114 bits (286), Expect = 1e-25
Identities = 86/283 (30%), Positives = 141/283 (49%), Gaps = 18/283 (6%)
Query: 77 VLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAG----CGLILHFVFQ 132
+L+C I EN V+ I T PM+ +G+LA +DLLAG L+L
Sbjct: 53 ILICC---FIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATT 109
Query: 133 Y-LVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAA 191
Y L P++ L G + + +ASV SLLAI ++RY+++ + ++ + LL++A
Sbjct: 110 YKLTPAQW--FLREGSMFVALSASVFSLLAIAIERYITMLK-MKLHNGSNNFRLFLLISA 166
Query: 192 TWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALL-SAAFFMVFGIMLHLYVRICQ 250
W +SL LG LP++GWNC++ ++CS V PL H L + F ++ ++ LY RI
Sbjct: 167 CWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYS 226
Query: 251 VVWRHAHQIALQQHCLAPPHLAATRKG-VGTLAVVLGTFGASWLPFAIYCV--VGSHEDP 307
+V + ++ +++ + + T+ +VL F A W P I + VG
Sbjct: 227 LVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKT 286
Query: 308 AVYTYAT---LLPATYNSMINPIIYAFRNQEIQRALWLLLCGC 347
+ L+ A NS NPIIY N+E++RA ++ C
Sbjct: 287 CDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCC 329
>gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens]
Length = 378
Score = 114 bits (284), Expect = 2e-25
Identities = 84/284 (29%), Positives = 137/284 (48%), Gaps = 24/284 (8%)
Query: 77 VLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVF---QY 133
VL V + I EN +V+ I M+ +G+LA DLLAG ++ + +
Sbjct: 44 VLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKT 103
Query: 134 LVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATW 193
S TV L G + + AS SLLAI ++R+L++ Y + + V LL+ W
Sbjct: 104 FSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHR-VFLLIGMCW 162
Query: 194 TVSLGLGLLPVLGWNCLAERAACSVVRPL-ARSHVALLSAAFFMVFGIMLHLYVRICQVV 252
++ LG LP+LGWNCL CS + PL ++ ++A + F + ++ LY RI +V
Sbjct: 163 LIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLV 222
Query: 253 WRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTY 312
+ ++A H + +A R T+ +V+ F A W P I ++ D A
Sbjct: 223 KSSSRKVA--NHNNSERSMALLR----TVVIVVSVFIACWSPLFILFLI----DVACRVQ 272
Query: 313 AT---------LLPATYNSMINPIIYAFRNQEIQRALWLLLCGC 347
A ++ A NS +NP+IY ++E++RA + L+C C
Sbjct: 273 ACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNC 316
>gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens]
Length = 364
Score = 106 bits (265), Expect = 3e-23
Identities = 78/275 (28%), Positives = 135/275 (49%), Gaps = 18/275 (6%)
Query: 90 NALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSET------VSLL 143
N LV+ I P++ L+ +LA AD AG + +F + T LL
Sbjct: 67 NLLVMVAIYVNRRFHFPIYYLMANLAAADFFAG---LAYFYLMFNTGPNTRRLTVSTWLL 123
Query: 144 TVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLP 203
G + S ASV++LLAI ++R+++++ + ++R + V +++ WT+++ +G +P
Sbjct: 124 RQGLIDTSLTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIP 182
Query: 204 VLGWNCLAERAACSVVRPLARSHVALLSAAFFMV-FGIMLHLYVRICQVVWRHAHQIALQ 262
+GWNC+ + CS + PL + A F +V F +M+ LY I V + +
Sbjct: 183 SVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYV--RQRTMRMS 240
Query: 263 QHCLAPPHLAATRKG-VGTLAVVLGTFGASWLPFAIYCVVG---SHEDPAVYTYATLLPA 318
+H P T + T+ +VLG F W P + ++ D Y LL A
Sbjct: 241 RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLA 300
Query: 319 TYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVP 353
+NS +NPIIY++R++E+ +LC C +S+ P
Sbjct: 301 EFNSAMNPIIYSYRDKEMSATFRQILC-CQRSENP 334
>gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens]
Length = 364
Score = 106 bits (265), Expect = 3e-23
Identities = 78/275 (28%), Positives = 135/275 (49%), Gaps = 18/275 (6%)
Query: 90 NALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSET------VSLL 143
N LV+ I P++ L+ +LA AD AG + +F + T LL
Sbjct: 67 NLLVMVAIYVNRRFHFPIYYLMANLAAADFFAG---LAYFYLMFNTGPNTRRLTVSTWLL 123
Query: 144 TVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLP 203
G + S ASV++LLAI ++R+++++ + ++R + V +++ WT+++ +G +P
Sbjct: 124 RQGLIDTSLTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIP 182
Query: 204 VLGWNCLAERAACSVVRPLARSHVALLSAAFFMV-FGIMLHLYVRICQVVWRHAHQIALQ 262
+GWNC+ + CS + PL + A F +V F +M+ LY I V + +
Sbjct: 183 SVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYV--RQRTMRMS 240
Query: 263 QHCLAPPHLAATRKG-VGTLAVVLGTFGASWLPFAIYCVVG---SHEDPAVYTYATLLPA 318
+H P T + T+ +VLG F W P + ++ D Y LL A
Sbjct: 241 RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLA 300
Query: 319 TYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVP 353
+NS +NPIIY++R++E+ +LC C +S+ P
Sbjct: 301 EFNSAMNPIIYSYRDKEMSATFRQILC-CQRSENP 334
>gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 103 bits (257), Expect = 2e-22
Identities = 84/300 (28%), Positives = 138/300 (46%), Gaps = 34/300 (11%)
Query: 77 VLLCVSGTVIAGENALVVALIASTPALRT-PMFVLVGSLATADLLAGCGLILHFVFQYLV 135
VL GT EN LV+ +I + +LR P + +GSLA ADLL + F+ ++
Sbjct: 121 VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF 180
Query: 136 ---PSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAAT 192
S V L +G + ASF ASV SL +DRY+S++ L Y T +
Sbjct: 181 HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM 240
Query: 193 WTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYV--RICQ 250
WT+++ + +LP+LGWNC ++ CS + P H+ F++ +L L++
Sbjct: 241 WTIAIVIAVLPLLGWNCEKLQSVCSDIFP----HIDETYLMFWIGVTSVLLLFIVYAYMY 296
Query: 251 VVWR-HAHQIALQQ---------HCLAPPHLAATR--------KGVGTLAVVLGTFGASW 292
++W+ H+H + + Q H + TR + TL ++L W
Sbjct: 297 ILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 356
Query: 293 ---LPFAIYCVVGSHED--PAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGC 347
L +Y V G V+ + ++L NS +NPIIYA R+++++ A + C
Sbjct: 357 GPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKDLRHAFRSMFPSC 415
>gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 103 bits (257), Expect = 2e-22
Identities = 84/300 (28%), Positives = 138/300 (46%), Gaps = 34/300 (11%)
Query: 77 VLLCVSGTVIAGENALVVALIASTPALRT-PMFVLVGSLATADLLAGCGLILHFVFQYLV 135
VL GT EN LV+ +I + +LR P + +GSLA ADLL + F+ ++
Sbjct: 121 VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF 180
Query: 136 ---PSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAAT 192
S V L +G + ASF ASV SL +DRY+S++ L Y T +
Sbjct: 181 HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM 240
Query: 193 WTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYV--RICQ 250
WT+++ + +LP+LGWNC ++ CS + P H+ F++ +L L++
Sbjct: 241 WTIAIVIAVLPLLGWNCEKLQSVCSDIFP----HIDETYLMFWIGVTSVLLLFIVYAYMY 296
Query: 251 VVWR-HAHQIALQQ---------HCLAPPHLAATR--------KGVGTLAVVLGTFGASW 292
++W+ H+H + + Q H + TR + TL ++L W
Sbjct: 297 ILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 356
Query: 293 ---LPFAIYCVVGSHED--PAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGC 347
L +Y V G V+ + ++L NS +NPIIYA R+++++ A + C
Sbjct: 357 GPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKDLRHAFRSMFPSC 415
>gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 103 bits (257), Expect = 2e-22
Identities = 84/300 (28%), Positives = 138/300 (46%), Gaps = 34/300 (11%)
Query: 77 VLLCVSGTVIAGENALVVALIASTPALRT-PMFVLVGSLATADLLAGCGLILHFVFQYLV 135
VL GT EN LV+ +I + +LR P + +GSLA ADLL + F+ ++
Sbjct: 121 VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF 180
Query: 136 ---PSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAAT 192
S V L +G + ASF ASV SL +DRY+S++ L Y T +
Sbjct: 181 HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM 240
Query: 193 WTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYV--RICQ 250
WT+++ + +LP+LGWNC ++ CS + P H+ F++ +L L++
Sbjct: 241 WTIAIVIAVLPLLGWNCEKLQSVCSDIFP----HIDETYLMFWIGVTSVLLLFIVYAYMY 296
Query: 251 VVWR-HAHQIALQQ---------HCLAPPHLAATR--------KGVGTLAVVLGTFGASW 292
++W+ H+H + + Q H + TR + TL ++L W
Sbjct: 297 ILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 356
Query: 293 ---LPFAIYCVVGSHED--PAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGC 347
L +Y V G V+ + ++L NS +NPIIYA R+++++ A + C
Sbjct: 357 GPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKDLRHAFRSMFPSC 415
>gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 103 bits (257), Expect = 2e-22
Identities = 84/300 (28%), Positives = 138/300 (46%), Gaps = 34/300 (11%)
Query: 77 VLLCVSGTVIAGENALVVALIASTPALRT-PMFVLVGSLATADLLAGCGLILHFVFQYLV 135
VL GT EN LV+ +I + +LR P + +GSLA ADLL + F+ ++
Sbjct: 121 VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF 180
Query: 136 ---PSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAAT 192
S V L +G + ASF ASV SL +DRY+S++ L Y T +
Sbjct: 181 HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM 240
Query: 193 WTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYV--RICQ 250
WT+++ + +LP+LGWNC ++ CS + P H+ F++ +L L++
Sbjct: 241 WTIAIVIAVLPLLGWNCEKLQSVCSDIFP----HIDETYLMFWIGVTSVLLLFIVYAYMY 296
Query: 251 VVWR-HAHQIALQQ---------HCLAPPHLAATR--------KGVGTLAVVLGTFGASW 292
++W+ H+H + + Q H + TR + TL ++L W
Sbjct: 297 ILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 356
Query: 293 ---LPFAIYCVVGSHED--PAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGC 347
L +Y V G V+ + ++L NS +NPIIYA R+++++ A + C
Sbjct: 357 GPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKDLRHAFRSMFPSC 415
>gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 103 bits (257), Expect = 2e-22
Identities = 84/300 (28%), Positives = 138/300 (46%), Gaps = 34/300 (11%)
Query: 77 VLLCVSGTVIAGENALVVALIASTPALRT-PMFVLVGSLATADLLAGCGLILHFVFQYLV 135
VL GT EN LV+ +I + +LR P + +GSLA ADLL + F+ ++
Sbjct: 121 VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF 180
Query: 136 ---PSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAAT 192
S V L +G + ASF ASV SL +DRY+S++ L Y T +
Sbjct: 181 HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM 240
Query: 193 WTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYV--RICQ 250
WT+++ + +LP+LGWNC ++ CS + P H+ F++ +L L++
Sbjct: 241 WTIAIVIAVLPLLGWNCEKLQSVCSDIFP----HIDETYLMFWIGVTSVLLLFIVYAYMY 296
Query: 251 VVWR-HAHQIALQQ---------HCLAPPHLAATR--------KGVGTLAVVLGTFGASW 292
++W+ H+H + + Q H + TR + TL ++L W
Sbjct: 297 ILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 356
Query: 293 ---LPFAIYCVVGSHED--PAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGC 347
L +Y V G V+ + ++L NS +NPIIYA R+++++ A + C
Sbjct: 357 GPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKDLRHAFRSMFPSC 415
>gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens]
Length = 439
Score = 103 bits (257), Expect = 2e-22
Identities = 84/300 (28%), Positives = 138/300 (46%), Gaps = 34/300 (11%)
Query: 77 VLLCVSGTVIAGENALVVALIASTPALRT-PMFVLVGSLATADLLAGCGLILHFVFQYLV 135
VL GT EN LV+ +I + +LR P + +GSLA ADLL + F+ ++
Sbjct: 88 VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF 147
Query: 136 ---PSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAAT 192
S V L +G + ASF ASV SL +DRY+S++ L Y T +
Sbjct: 148 HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM 207
Query: 193 WTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYV--RICQ 250
WT+++ + +LP+LGWNC ++ CS + P H+ F++ +L L++
Sbjct: 208 WTIAIVIAVLPLLGWNCEKLQSVCSDIFP----HIDETYLMFWIGVTSVLLLFIVYAYMY 263
Query: 251 VVWR-HAHQIALQQ---------HCLAPPHLAATR--------KGVGTLAVVLGTFGASW 292
++W+ H+H + + Q H + TR + TL ++L W
Sbjct: 264 ILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICW 323
Query: 293 ---LPFAIYCVVGSHED--PAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGC 347
L +Y V G V+ + ++L NS +NPIIYA R+++++ A + C
Sbjct: 324 GPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKDLRHAFRSMFPSC 382
>gi|4502929 cannabinoid receptor 2 (macrophage) [Homo sapiens]
Length = 360
Score = 101 bits (251), Expect = 1e-21
Identities = 90/276 (32%), Positives = 130/276 (47%), Gaps = 21/276 (7%)
Query: 77 VLLCVSGTVIAGENALVVALIASTPALRT-PMFVLVGSLATADLLAG----CGLILHFVF 131
VL + G + A EN V+ LI S+ LR P ++ +GSLA AD LA C + VF
Sbjct: 38 VLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVF 97
Query: 132 QYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAA 191
+ V S+ V LL +G + +F ASV SLL +DRYL L +Y + T + L
Sbjct: 98 -HGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGI 156
Query: 192 TWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQV 251
W +S + LP++GW C CS + PL + LLS F+ F + + V
Sbjct: 157 MWVLSALVSYLPLMGWTCCPR--PCSELFPLIPNDY-LLSWLLFIAF-LFSGIIYTYGHV 212
Query: 252 VWR-HAHQIALQQH-CLAPPHLAATRKGV---GTLAVVLGTFGASWLPFAI-----YCVV 301
+W+ H H +L H P +A R V TL +VL W P
Sbjct: 213 LWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATT 272
Query: 302 GSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQ 337
S + + + ++L NSM+NP+IYA R+ EI+
Sbjct: 273 LSDQVKKAFAFCSML-CLINSMVNPVIYALRSGEIR 307
>gi|4501951 adenosine A2b receptor [Homo sapiens]
Length = 332
Score = 100 bits (248), Expect = 3e-21
Identities = 85/296 (28%), Positives = 134/296 (45%), Gaps = 49/296 (16%)
Query: 79 LCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSE 138
L ++ +AG N LV A + + L+TP + SLA AD+ G F + +
Sbjct: 15 LVIAALSVAG-NVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGL-----FAIPFAI--- 65
Query: 139 TVSL----------LTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLL 188
T+SL F++ +S+ SLLA+ VDRYL++ L Y S T +
Sbjct: 66 TISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGV 125
Query: 189 LAATWTVSLGLGLLPVLGWNCL-------------AERAACSVVRPLARSHVALLSAAFF 235
+A W ++ G+GL P LGWN +C +V+ L + V + +F
Sbjct: 126 IAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYF 185
Query: 236 MVFG-------IMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTF 288
FG IML +Y++I V R + L H + L +LA+++G F
Sbjct: 186 NFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDH--SRTTLQREIHAAKSLAMIVGIF 243
Query: 289 GASWLP-FAIYCVV------GSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQ 337
WLP A+ CV G ++ A LL + NS++NPI+YA+RN++ +
Sbjct: 244 ALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILL-SHANSVVNPIVYAYRNRDFR 298
>gi|193083134 melanocortin 1 receptor [Homo sapiens]
Length = 317
Score = 97.8 bits (242), Expect = 1e-20
Identities = 97/306 (31%), Positives = 137/306 (44%), Gaps = 47/306 (15%)
Query: 60 LSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADL 119
L+A G V+ D L G V ENALVVA IA L +PM+ + LA +DL
Sbjct: 26 LAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDL 85
Query: 120 LAGCGLILHFVFQYLVPSETVSLLTVGFLVA------------------SFAASVSSLLA 161
L +L + + LL G LVA S +S+ L A
Sbjct: 86 LVSGSNVLE--------TAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGA 137
Query: 162 ITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRP 221
I VDRY+S++ AL Y+S TL +AA W S+ L + ++ +A C VV
Sbjct: 138 IAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAV-LLCLVVFF 196
Query: 222 LARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTL 281
LA + +L A + +H+ R CQ HA IA P H KG TL
Sbjct: 197 LA---MLVLMAVLY------VHMLARACQ----HAQGIARLHKRQRPVHQGFGLKGAVTL 243
Query: 282 AVVLGTFGASWLPFAIY--CVVGSHEDP---AVYTYATLLPATY--NSMINPIIYAFRNQ 334
++LG F W PF ++ +V E P ++ L A N++I+P+IYAF +Q
Sbjct: 244 TILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQ 303
Query: 335 EIQRAL 340
E++R L
Sbjct: 304 ELRRTL 309
>gi|170671732 melanocortin 3 receptor [Homo sapiens]
Length = 323
Score = 97.8 bits (242), Expect = 1e-20
Identities = 78/283 (27%), Positives = 124/283 (43%), Gaps = 32/283 (11%)
Query: 83 GTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSL 142
G V EN LV+ + L +PM+ + SLA AD+L L + +V S+ ++
Sbjct: 49 GIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTF 108
Query: 143 ----------LTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAAT 192
+ + S AS+ +LLAI VDRY++++ AL Y+S T+ L+ A
Sbjct: 109 EDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAI 168
Query: 193 WTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVV 252
W C +V ++ + L FF + +M LYV +
Sbjct: 169 WV--------------CCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFA 214
Query: 253 WRHAHQI-ALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCV--VGSHEDPAV 309
H +I AL P + KG T+ ++LG F W PF ++ V + +P
Sbjct: 215 RLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYC 274
Query: 310 YTYAT-----LLPATYNSMINPIIYAFRNQEIQRALWLLLCGC 347
Y L+ NS+I+P+IYAFR+ E++ +LCGC
Sbjct: 275 ICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGC 317
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 97.1 bits (240), Expect = 2e-20
Identities = 94/318 (29%), Positives = 142/318 (44%), Gaps = 42/318 (13%)
Query: 62 AGPPGLLLPAVNPW-DVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLL 120
AGPP P + W LCV + A N+L++ALI + PALR + SL T+DL+
Sbjct: 17 AGPPSA--PGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLM 74
Query: 121 AGCGLI----LHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTY 176
G ++ L+ ++ V + + LL F V +AS+ +L I++DRYL + + L Y
Sbjct: 75 VGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRY 134
Query: 177 YSRRTLLGVHLLLAATWTVSLGLGLLP-VLGWNCL--AERAACSVVRPLARSHVALLSA- 232
R T L L+ W+++ LP +LGW+ L A R LA L+++
Sbjct: 135 KLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASG 194
Query: 233 -AFFMVFGIMLHLYVRICQVVWRHAHQIA--------------------------LQQHC 265
FF+ G + Y RI + A Q+A
Sbjct: 195 LTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRR 254
Query: 266 LAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHED---PAVYTYATLLPATYNS 322
LA H K TL ++LG F +WLPF + +V + D P ++ T L NS
Sbjct: 255 LATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWL-GYCNS 313
Query: 323 MINPIIYAFRNQEIQRAL 340
+NPIIY ++ +RAL
Sbjct: 314 TMNPIIYPLFMRDFKRAL 331
>gi|119508433 melanocortin 4 receptor [Homo sapiens]
Length = 332
Score = 96.3 bits (238), Expect = 4e-20
Identities = 74/279 (26%), Positives = 131/279 (46%), Gaps = 31/279 (11%)
Query: 83 GTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSE---- 138
G + EN LV+ IA L +PM+ + SLA AD+L + L+ S
Sbjct: 55 GVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDA 114
Query: 139 ---TVSLLTV--GFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATW 193
TV++ V + +S AS+ SLL+I VDRY +++ AL Y++ T+ V ++++ W
Sbjct: 115 QSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIW 174
Query: 194 TVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVW 253
G+L ++ + + + L FF + +M LYV + +
Sbjct: 175 AACTVSGIL--------------FIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMAR 220
Query: 254 RHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCV--VGSHEDPAVYT 311
H +IA+ A A KG TL +++G F W PF ++ + + ++P
Sbjct: 221 LHIKRIAVLPGTGA-IRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVC 279
Query: 312 YAT-----LLPATYNSMINPIIYAFRNQEIQRALWLLLC 345
+ + L+ NS+I+P+IYA R+QE+++ ++C
Sbjct: 280 FMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIIC 318
>gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens]
Length = 318
Score = 95.9 bits (237), Expect = 5e-20
Identities = 77/271 (28%), Positives = 127/271 (46%), Gaps = 13/271 (4%)
Query: 90 NALVVALIASTPALRTPMFVLVGSLATADLLAGCGLI-LHFVFQYLVPSETVSLLTVGFL 148
N LV+ ++ P+L+T F + SLA AD+ G ++ L V + S L + L
Sbjct: 30 NVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCL 89
Query: 149 VASFA-ASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGW 207
+ F AS+ SLLAI VDRYL + + Y T + L L W VS +GL P+ GW
Sbjct: 90 LLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGW 149
Query: 208 NCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRI---CQV------VWRHAHQ 258
N V L+ V+++ + + F + +++ + C + + R+
Sbjct: 150 NMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLS 209
Query: 259 IALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIY-CVV-GSHEDPAVYTYATLL 316
+ L K +L +VL F SWLP +I C++ + E P + Y +L
Sbjct: 210 LNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGIL 269
Query: 317 PATYNSMINPIIYAFRNQEIQRALWLLLCGC 347
+ NSM+NPI+YA++ ++ + L+L C
Sbjct: 270 LSHANSMMNPIVYAYKIKKFKETYLLILKAC 300
>gi|4503459 sphingosine-1-phosphate receptor 4 precursor [Homo
sapiens]
Length = 384
Score = 89.7 bits (221), Expect = 4e-18
Identities = 79/285 (27%), Positives = 128/285 (44%), Gaps = 21/285 (7%)
Query: 78 LLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQ----- 132
L + ++ EN LV+A I S R ++ + ++ +DLL G + + +
Sbjct: 52 LSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTF 111
Query: 133 YLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAAT 192
L P++ L G L + AAS SLL +R+ ++ + V+ +
Sbjct: 112 RLAPAQW--FLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLC 169
Query: 193 WTVSLGLGLLPVLGWNCLAERAACSVVRPL-ARSHVALLSAAFFMVFGIMLHLYVRICQV 251
W ++ LG+LP+LGWNCL CS + PL ++ ++ F V ++ LY I ++
Sbjct: 170 WLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRL 229
Query: 252 VWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLP---FAIYCVVGSHEDPA 308
V A Q P R+ + T+ ++L F W P + V GS+
Sbjct: 230 VQ------ASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQ 283
Query: 309 VYTYA---TLLPATYNSMINPIIYAFRNQEIQRA-LWLLLCGCFQ 349
Y L A NS +NPIIY+FR++E+ RA L L CGC +
Sbjct: 284 EYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLR 328
>gi|5174535 melanocortin 5 receptor [Homo sapiens]
Length = 325
Score = 89.0 bits (219), Expect = 6e-18
Identities = 74/285 (25%), Positives = 130/285 (45%), Gaps = 42/285 (14%)
Query: 83 GTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSL 142
G + EN LV+ I L +PM+ V SLA AD+L + YL+ ++ + +
Sbjct: 47 GVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVI 106
Query: 143 LTV----------GFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAAT 192
+ S AS+ SLLAI VDRY++++ AL Y+ T ++A
Sbjct: 107 ADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGI 166
Query: 193 WTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVV 252
W G G++ +L + V+ + L+S F M+F +++ LY+ + +
Sbjct: 167 WAFCTGCGIVFIL------YSESTYVI-------LCLISMFFAMLF-LLVSLYIHMFLLA 212
Query: 253 WRHAHQIALQQHCLAPPHLAATR-----KGVGTLAVVLGTFGASWLPFAIYCVVGSHEDP 307
H +IA A P ++ R +G T+ ++LG F W PF ++ +
Sbjct: 213 RTHVKRIA------ALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQ 266
Query: 308 AVYT-------YATLLPATYNSMINPIIYAFRNQEIQRALWLLLC 345
+Y L+ NS+++P+IYAFR+QE+++ ++C
Sbjct: 267 NLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIIC 311
>gi|30425400 G protein-coupled receptor 119 [Homo sapiens]
Length = 335
Score = 87.0 bits (214), Expect = 2e-17
Identities = 80/289 (27%), Positives = 128/289 (44%), Gaps = 20/289 (6%)
Query: 77 VLLCVSGTVIAGENALV-VALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLV 135
V+L V ++I N LV VA++ +LA AD L G + Q
Sbjct: 9 VILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSS 68
Query: 136 PS----ETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAA 191
PS +T+ L + F+ +S AASV +++ IT DRYL++ Y + +A
Sbjct: 69 PSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAG 128
Query: 192 TWTVSLGLGLLP--VLGWNCLAERAACSVVRPLARSHVALLS-AAFFMVFGIMLHLYVRI 248
W VS +G LP + + A + CS V LS FF + + Y +
Sbjct: 129 LWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDM 188
Query: 249 CQVVWRHAHQIALQQHCLA------PPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVV- 301
++ H+ QI +H A P + K + T++V++G+F SW PF I +V
Sbjct: 189 LKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQ 248
Query: 302 ----GSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCG 346
H + Y LL NS++NP+IYA+ +E++ L+ + G
Sbjct: 249 VACQECHLYLVLERYLWLL-GVGNSLLNPLIYAYWQKEVRLQLYHMALG 296
>gi|115305569 adenosine A1 receptor [Homo sapiens]
Length = 326
Score = 84.3 bits (207), Expect = 2e-16
Identities = 74/271 (27%), Positives = 124/271 (45%), Gaps = 24/271 (8%)
Query: 90 NALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPS---ETVSLLTVG 146
N LV+ + ALR F + SLA AD+ G +I + + P T ++
Sbjct: 27 NVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACP 86
Query: 147 FLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLG 206
L+ + +S+ +LLAI VDRYL + L Y T + +A W +S +GL P+ G
Sbjct: 87 VLILT-QSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFG 145
Query: 207 WNCLA--ERAAC---SVVRPLARSHVALLSAAFFMVFG-----------IMLHLYVRICQ 250
WN L+ ERA S+ P+ + + + +MV+ +M+ +Y+ +
Sbjct: 146 WNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFY 205
Query: 251 VVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIY-CVV---GSHED 306
++ + ++ + K +LA++L F SWLP I C+ S
Sbjct: 206 LIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHK 265
Query: 307 PAVYTYATLLPATYNSMINPIIYAFRNQEIQ 337
P++ TY + NS +NPI+YAFR Q+ +
Sbjct: 266 PSILTYIAIFLTHGNSAMNPIVYAFRIQKFR 296
>gi|4501947 adenosine A1 receptor [Homo sapiens]
Length = 326
Score = 84.3 bits (207), Expect = 2e-16
Identities = 74/271 (27%), Positives = 124/271 (45%), Gaps = 24/271 (8%)
Query: 90 NALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPS---ETVSLLTVG 146
N LV+ + ALR F + SLA AD+ G +I + + P T ++
Sbjct: 27 NVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACP 86
Query: 147 FLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLG 206
L+ + +S+ +LLAI VDRYL + L Y T + +A W +S +GL P+ G
Sbjct: 87 VLILT-QSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFG 145
Query: 207 WNCLA--ERAAC---SVVRPLARSHVALLSAAFFMVFG-----------IMLHLYVRICQ 250
WN L+ ERA S+ P+ + + + +MV+ +M+ +Y+ +
Sbjct: 146 WNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFY 205
Query: 251 VVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIY-CVV---GSHED 306
++ + ++ + K +LA++L F SWLP I C+ S
Sbjct: 206 LIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHK 265
Query: 307 PAVYTYATLLPATYNSMINPIIYAFRNQEIQ 337
P++ TY + NS +NPI+YAFR Q+ +
Sbjct: 266 PSILTYIAIFLTHGNSAMNPIVYAFRIQKFR 296
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 83.6 bits (205), Expect = 3e-16
Identities = 85/313 (27%), Positives = 128/313 (40%), Gaps = 49/313 (15%)
Query: 77 VLLCVSGTVIAGE---NALVVALIASTPALR---TPMFVLVGSLATADLLAGCGLI---- 126
VLL TVI N LV+ + LR T F++ SLA ADLL ++
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV--SLAFADLLVSVLVMPFGA 78
Query: 127 LHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLY-NALTYYSRRTLLGV 185
+ V + E L+ V AS+ L I++DRY ++ L Y ++ T L +
Sbjct: 79 IELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRI 138
Query: 186 HLLLAATWTVSLGLGLLPVL-GWNCL----------------AERAACSVVRPLARSHVA 228
L+L W + + LP++ GWN + + V +P A +
Sbjct: 139 ALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYA---IT 195
Query: 229 LLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPH-------------LAATR 275
AF++ F +M+ Y RI HAHQI + Q A +
Sbjct: 196 CSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTET 255
Query: 276 KGVGTLAVVLGTFGASWLPFAIYCVVGSHED---PAVYTYATLLPATYNSMINPIIYAFR 332
K TL +++G F W PF + +V D P A L NS +NP +YAF
Sbjct: 256 KAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFL 315
Query: 333 NQEIQRALWLLLC 345
N+ +RA ++LC
Sbjct: 316 NKSFRRAFLIILC 328
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.136 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,780,528
Number of Sequences: 37866
Number of extensions: 618609
Number of successful extensions: 5974
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 350
Number of HSP's successfully gapped in prelim test: 429
Number of HSP's that attempted gapping in prelim test: 4454
Number of HSP's gapped (non-prelim): 1358
length of query: 362
length of database: 18,247,518
effective HSP length: 104
effective length of query: 258
effective length of database: 14,309,454
effective search space: 3691839132
effective search space used: 3691839132
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.