Search of human proteins with 4757982

Search of human proteins with 4757982

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo
sapiens]
         (494 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]   1030   0.0  
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   660   0.0  
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   516   e-146
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   475   e-134
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   440   e-123
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     429   e-120
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   426   e-119
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   422   e-118
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   421   e-118
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   409   e-114
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   338   9e-93
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   332   5e-91
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   331   1e-90
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   329   3e-90
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   302   5e-82
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   290   2e-78
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   281   7e-76
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              232   5e-61
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   219   6e-57
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   219   6e-57
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   203   3e-52
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              179   7e-45
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   162   6e-40
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   158   1e-38
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   157   2e-38
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]        87   3e-17
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]          87   3e-17
gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]        87   5e-17
gi|4504023 glycine receptor, beta [Homo sapiens]                       86   6e-17
gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]        84   2e-16

>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score = 1030 bits (2664), Expect = 0.0
 Identities = 494/494 (100%), Positives = 494/494 (100%)

Query: 1   MLTSKGQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVT 60
           MLTSKGQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVT
Sbjct: 1   MLTSKGQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVT 60

Query: 61  VHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDI 120
           VHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDI
Sbjct: 61  VHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDI 120

Query: 121 VLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWT 180
           VLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWT
Sbjct: 121 VLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWT 180

Query: 181 YDKAEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLP 240
           YDKAEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLP
Sbjct: 181 YDKAEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLP 240

Query: 241 MFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVV 300
           MFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVV
Sbjct: 241 MFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVV 300

Query: 301 PLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLD 360
           PLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLD
Sbjct: 301 PLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLD 360

Query: 361 KTRGTGSDAVPRGLARRPAKGKLASHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWVV 420
           KTRGTGSDAVPRGLARRPAKGKLASHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWVV
Sbjct: 361 KTRGTGSDAVPRGLARRPAKGKLASHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWVV 420

Query: 421 ENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTA 480
           ENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTA
Sbjct: 421 ENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTA 480

Query: 481 GLFLQPLLGNTGKS 494
           GLFLQPLLGNTGKS
Sbjct: 481 GLFLQPLLGNTGKS 494


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  660 bits (1703), Expect = 0.0
 Identities = 320/471 (67%), Positives = 375/471 (79%), Gaps = 21/471 (4%)

Query: 34  EERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDY 93
           E RLF +LF  YN+ IRPV NVSDPV +HFEV+++QL  VDEVNQIMETNLWL+ IWNDY
Sbjct: 35  EHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDY 94

Query: 94  KLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAI 153
           KL+W+P +Y G E +RVPA KIWKPDIVLYNNAVGDFQV+ KTKALLKY G +TW PPAI
Sbjct: 95  KLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAI 154

Query: 154 FKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASG 213
           FKSSC +D+T+FPFD+QNC++KFGSW+YDKA+IDL++IGS +++ D+WE+ EW II A G
Sbjct: 155 FKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPG 214

Query: 214 YKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVT 273
           YKHDIKYNCCEEIY DITYS YIRRLP+FYTINLIIPCL ISFLTVLVFYLPSDCGEKVT
Sbjct: 215 YKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVT 274

Query: 274 LCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPT 333
           LCISVLLSLTVFLLVITETIPSTSLV+PL+GEYLLFTMIFVTLSIV+TVFVLN+HYRTPT
Sbjct: 275 LCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPT 334

Query: 334 THTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGL-----------ARRPAKGK 382
           THTMP WVKTVFL LLP+V+ M  P   T   G+   PR L           +R  +KG 
Sbjct: 335 THTMPSWVKTVFLNLLPRVMFMTRP---TSNEGNAQKPRPLYGAELSNLNCFSRAESKG- 390

Query: 383 LASHGEPRHLKECFHCHK-----SNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQ 437
               G P     C +CH      SN  A   R  S + +  V+  S  SPE+++ I SV+
Sbjct: 391 -CKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVK 449

Query: 438 FIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPLL 488
           +IAENMK+ NE KE++DDWKYVAMV+DR+FLWVF +VC+ GTAGLFLQPL+
Sbjct: 450 YIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLM 500


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  516 bits (1328), Expect = e-146
 Identities = 258/473 (54%), Positives = 327/473 (69%), Gaps = 22/473 (4%)

Query: 33  TEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWND 92
           TE+RLF  LF  YN++ RPV N SD V V F ++I QL +VDE NQ+M TN+WL+  W+D
Sbjct: 58  TEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSD 117

Query: 93  YKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPA 152
           YKLRW+P ++  I +LRVP++ IW PDIVLYNNA G+F V   TKA L   G + W PPA
Sbjct: 118 YKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPA 177

Query: 153 IFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDAS 212
           I+KSSC +D+TFFPFD QNC +KFGSWTYDKA+IDL  +   VD+ D+WE+ EW I++A+
Sbjct: 178 IYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNAT 237

Query: 213 GYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKV 272
           G  +  KY+CC EIY D+TY+F IRRLP+FYTINLIIPCL IS LTVLVFYLPSDCGEK+
Sbjct: 238 GTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKI 297

Query: 273 TLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTP 332
           TLCISVLLSLTVFLL+ITE IPSTSLV+PL+GEYLLFTMIFVTLSIV+TVFVLN+H+R+P
Sbjct: 298 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP 357

Query: 333 TTHTMPRWVKTVFLKLLPQVLLMRWPLDKTR----------------GTGSDAVPRGLA- 375
           +THTMP WV+   L  +P+ LLM  P                      +  DA  R +  
Sbjct: 358 STHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVV 417

Query: 376 RRPAKGKLASHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWVVENSEHSPEVEDVINS 435
               +   A H  P     C H H  +  +  K     Q  + ++     SP ++  +  
Sbjct: 418 EEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLL-----SPHMQKALEG 472

Query: 436 VQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPLL 488
           V +IA++++S +    V++DWKYVAMV+DR+FLW+FIIVC  GT GLFL P L
Sbjct: 473 VHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFL 525


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  475 bits (1223), Expect = e-134
 Identities = 220/325 (67%), Positives = 272/325 (83%)

Query: 34  EERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDY 93
           EERL  KLFS YN++ RPV N+SD V V F ++I QL +VDE NQ+M TN+W++  W+DY
Sbjct: 37  EERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDY 96

Query: 94  KLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAI 153
           KLRWDP +Y+ + ++R+P++ IW+PDIVLYNNA GDF V   TKA L ++G + WTPPAI
Sbjct: 97  KLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAI 156

Query: 154 FKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASG 213
           +KSSC +D+TFFPFD QNC++KFGSWTYDKA+IDL+ + S+VD  DFWE+ EW I+DA G
Sbjct: 157 YKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVG 216

Query: 214 YKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVT 273
             +  KY CC EIY DITY+F IRRLP+FYTINLIIPCL IS LTVLVFYLPS+CGEK+T
Sbjct: 217 TYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKIT 276

Query: 274 LCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPT 333
           LCISVLLSLTVFLL+ITE IPSTSLV+PL+GEYLLFTMIFVTLSIV+TVFVLN+H+R+P 
Sbjct: 277 LCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPR 336

Query: 334 THTMPRWVKTVFLKLLPQVLLMRWP 358
           THTMP WV+ VFL ++P++LLM+ P
Sbjct: 337 THTMPTWVRRVFLDIVPRLLLMKRP 361



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 34/63 (53%), Positives = 48/63 (76%)

Query: 426 SPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQ 485
           SP +   +  VQ+IA+++K+ +    V++DWKYVAMV+DR+FLW+FIIVC+ GT GLFL 
Sbjct: 561 SPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLP 620

Query: 486 PLL 488
           P L
Sbjct: 621 PWL 623


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  440 bits (1131), Expect = e-123
 Identities = 223/467 (47%), Positives = 302/467 (64%), Gaps = 6/467 (1%)

Query: 27  GCVGCATEERLFHKLF--SHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNL 84
           G  G  TEERL   L   S YN+ IRP  N S+ VTV   V++ QL +V E  QIM TN+
Sbjct: 22  GVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNV 81

Query: 85  WLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNG 144
           WL   W DY+L W P E+D ++ +R+P+  IW PD+VLYNNA G ++V   + A++ Y+G
Sbjct: 82  WLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDG 141

Query: 145 MITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENS 204
            I W PPAI+KS+C +++  FPFD QNC++KF SWTYD+ EIDL++      ++DF  + 
Sbjct: 142 SIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSG 201

Query: 205 EWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYL 264
           EW+I+   G +++   N  +  Y DITY F IRR P+FYTINLIIPC+ I+ L +LVFYL
Sbjct: 202 EWDIVALPGRRNE---NPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYL 258

Query: 265 PSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFV 324
           PSDCGEK+TLCISVLL+LTVFLL+I++ +P TSL VPLVG+YL+FTM+ VT SIV +V V
Sbjct: 259 PSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCV 318

Query: 325 LNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLA 384
           LN+H+R+PTTHTM  WVK VFL+ LP +L M+ P             R   R  A     
Sbjct: 319 LNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFF 378

Query: 385 SHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWVVENSEH-SPEVEDVINSVQFIAENM 443
                     CF    S +           P+     + E     + + ++ V+FIA++M
Sbjct: 379 REAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHM 438

Query: 444 KSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPLLGN 490
           +S ++ + V +DWKYVAMV+DR+FLW+F+ VCVFGT G+FLQPL  N
Sbjct: 439 RSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQN 485


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  429 bits (1102), Expect = e-120
 Identities = 209/467 (44%), Positives = 300/467 (64%), Gaps = 12/467 (2%)

Query: 28  CVGCATEERLFHKLFS--HYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLW 85
           C     EE+L   L +   YN  IRP  + S  +++  ++++ QL +V+E  QIM TN+W
Sbjct: 21  CRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVW 80

Query: 86  LRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGM 145
           L+  W DY+L W+   Y+G+  LR+PA +IW PDIVLYNNA G ++V   T  +++ NG 
Sbjct: 81  LKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGS 140

Query: 146 ITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSE 205
           + W PPAI+KS+C +++ +FPFD QNC+LKF SWTYD  EID++++     M+DF  + E
Sbjct: 141 VLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGE 200

Query: 206 WEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLP 265
           W+I+   G +     N  +  Y D+TY F I+R P+FYTINLIIPC+  + L +LVFYLP
Sbjct: 201 WDIVALPGRR---TVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLP 257

Query: 266 SDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVL 325
           SDCGEK+TLCISVLL+LT FLL+I++ +P TSL VPL+G+YL+FTM+ VT SIV +V VL
Sbjct: 258 SDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVL 317

Query: 326 NIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLAS 385
           N+H+R+P+THTM  WVK  FL  LP  L M+ P   +    +    +    +P     ++
Sbjct: 318 NVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATATST 377

Query: 386 HGEPRHLKECFHCHKSNELATSKRRLSHQPLQ-----WVVENSEHSPEVEDVINSVQFIA 440
                +    +  + ++  A SK      P+      W+  +     +V++ +  V FIA
Sbjct: 378 SPSNFYGNSMYFVNPAS--AASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIA 435

Query: 441 ENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPL 487
           ++MK+ +E + V +DWKYVAMVVDR+FLWVF+ VCV GT GLFL PL
Sbjct: 436 QHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPL 482


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  426 bits (1095), Expect = e-119
 Identities = 212/452 (46%), Positives = 301/452 (66%), Gaps = 51/452 (11%)

Query: 34  EERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDY 93
           E+ L   LF  Y +++RPVE+++D + + F +AI+QL +VDE NQ+M TN+WL+  W D 
Sbjct: 47  EDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDV 106

Query: 94  KLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAI 153
           KLRW+P +Y GI+ +RVP+D +W PDIVL++NA G F+    TK +++YNG +TWTPPA 
Sbjct: 107 KLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTS-TKTVIRYNGTVTWTPPAN 165

Query: 154 FKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASG 213
           +KSSC +D+TFFPFD QNCS+KFGSWTYD +++D+++    VD  DF++N EWEI+ A+G
Sbjct: 166 YKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATG 225

Query: 214 YKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVT 273
            K +   +CC   Y  +TYSF I+RLP+FYT+ LIIPC+ +SFLTVLVFYLPS+ GEK+ 
Sbjct: 226 SKGNRTDSCCW--YPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKIC 283

Query: 274 LCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPT 333
           LC SVL+SLTVFLLVI E IPS+S V+PL+GEYL+FTMIFVTLSI+VTVF +NIH+R+ +
Sbjct: 284 LCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSS 343

Query: 334 TH-TMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPRHL 392
           TH  M   V+ +FL  LP++L MR  +D+                               
Sbjct: 344 THNAMAPLVRKIFLHTLPKLLCMRSHVDR------------------------------- 372

Query: 393 KECFHCHKSNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEV 452
              +   K    + S  + S   L             E  ++S+++I  ++   N+ +EV
Sbjct: 373 ---YFTQKEETESGSGPKSSRNTL-------------EAALDSIRYITRHIMKENDVREV 416

Query: 453 EDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFL 484
            +DWK++A V+DR+FLW F+ V + G+ GLF+
Sbjct: 417 VEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFV 448


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  422 bits (1085), Expect = e-118
 Identities = 210/461 (45%), Positives = 299/461 (64%), Gaps = 29/461 (6%)

Query: 29  VGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRH 88
           +G   E RL  KLF  Y+  +RPVE+    V V   + + QL NVDEVNQI+ TN+ L+ 
Sbjct: 19  LGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQ 78

Query: 89  IWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITW 148
            W DY L+W+P +Y G++ + +P++KIW+PD+VLYNNA GDF +   TK LL+Y G ITW
Sbjct: 79  QWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITW 138

Query: 149 TPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEI 208
           TPPAIFKS C + +T FPFD QNCS+K G+WTYD + + +     + D+++F E+ EW I
Sbjct: 139 TPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVI 198

Query: 209 IDASGYKHDIKYNCCEEI-YTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSD 267
            ++ G+KH + Y+CC +  Y DITY F ++RLP+++ +N+IIPCL  SFLT LVFYLP+D
Sbjct: 199 KESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTD 258

Query: 268 CGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNI 327
            GEK+TL ISVLLSLTVFLLVI E IPSTS  VPL+G+Y+LFTM+FV  SI++TV V+N 
Sbjct: 259 SGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINT 318

Query: 328 HYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHG 387
           H+R+P+TH MP WV+ VF+  +P ++                      +RP++ K     
Sbjct: 319 HHRSPSTHVMPNWVRKVFIDTIPNIMFF-----------------STMKRPSREK----- 356

Query: 388 EPRHLKECFHCHKSNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHN 447
                K+ F   +  +++    +    P+ +     +H PEV+  I  +++IAE MKS  
Sbjct: 357 ---QDKKIF--TEDIDISDISGKPGPPPMGFHSPLIKH-PEVKSAIEGIKYIAETMKSDQ 410

Query: 448 ETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPLL 488
           E+     +WKYVAMV+D + L VF++VC+ GT  +F   L+
Sbjct: 411 ESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLI 451


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  421 bits (1083), Expect = e-118
 Identities = 215/455 (47%), Positives = 303/455 (66%), Gaps = 34/455 (7%)

Query: 34  EERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDY 93
           E+ L   LF  Y +++RPV + +D + V+F + I+QL +VDE NQ+M TN+WL+  W D+
Sbjct: 29  EDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDH 88

Query: 94  KLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAI 153
           KLRW+P +Y GI +++VP++ +W PDIVL+ NA G F+    TK ++K NG + WTPPA 
Sbjct: 89  KLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPPAS 148

Query: 154 FKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASG 213
           +KSSC MD+TFFPFD QNCS+KFGSWTYD   +DL++I   VD  DF++N EWEI++A G
Sbjct: 149 YKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILNAKG 208

Query: 214 YKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVT 273
            K + +       Y  ITYSF +RRLP+FYT+ LIIPCL +SFLTVLVFYLPSD GEK++
Sbjct: 209 MKGNRRDGVYS--YPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLS 266

Query: 274 LCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPT 333
           L  SVL+SLTVFLLVI E IPS+S V+PL+GEYLLF MIFVTLSI+VTVFV+N+H+R+ +
Sbjct: 267 LSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSS 326

Query: 334 T-HTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPRHL 392
           T H M  WVK +FL+ LP++L M+  +D+      +      ++   KGK+         
Sbjct: 327 TYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEE-----SQPVVKGKVLEK------ 375

Query: 393 KECFHCHKSNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEV 452
                  K  +L+  ++ L                 +E   +S+++I+ ++K  +   +V
Sbjct: 376 ------KKQKQLSDGEKVL--------------VAFLEKAADSIRYISRHVKKEHFISQV 415

Query: 453 EDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPL 487
             DWK+VA V+DR+FLW+F+IV V G+  +F   L
Sbjct: 416 VQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTPAL 450


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  409 bits (1051), Expect = e-114
 Identities = 211/486 (43%), Positives = 301/486 (61%), Gaps = 54/486 (11%)

Query: 29  VGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLR- 87
           +G   E RL  KLF  Y+  +RPVE+    V V   + + QL NVDEVNQI+ TN+ L+ 
Sbjct: 19  LGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQ 78

Query: 88  --------------------HI----WNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLY 123
                               H+    W DY L+W+P +Y G++ + +P++KIW+PD+VLY
Sbjct: 79  GDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLY 138

Query: 124 NNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDK 183
           NNA GDF +   TK LL+Y G ITWTPPAIFKS C + +T FPFD QNCS+K G+WTYD 
Sbjct: 139 NNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDG 198

Query: 184 AEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDIKYNCCEEI-YTDITYSFYIRRLPMF 242
           + + +     + D+++F E+ EW I ++ G+KH + Y+CC +  Y DITY F ++RLP++
Sbjct: 199 SVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLY 258

Query: 243 YTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPL 302
           + +N+IIPCL  SFLT LVFYLP+D GEK+TL ISVLLSLTVFLLVI E IPSTS  VPL
Sbjct: 259 FIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPL 318

Query: 303 VGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKT 362
           +G+Y+LFTM+FV  SI++TV V+N H+R+P+TH MP WV+ VF+  +P ++         
Sbjct: 319 IGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFF------- 371

Query: 363 RGTGSDAVPRGLARRPAKGKLASHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWVVEN 422
                        +RP++ K          K+ F   +  +++    +    P+ +    
Sbjct: 372 ----------STMKRPSREK--------QDKKIF--TEDIDISDISGKPGPPPMGFHSPL 411

Query: 423 SEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGL 482
            +H PEV+  I  +++IAE MKS  E+     +WKYVAMV+D + L VF++VC+ GT  +
Sbjct: 412 IKH-PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAV 470

Query: 483 FLQPLL 488
           F   L+
Sbjct: 471 FAGRLI 476


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  338 bits (866), Expect = 9e-93
 Identities = 162/444 (36%), Positives = 264/444 (59%), Gaps = 13/444 (2%)

Query: 35  ERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYK 94
           ++LF+ LF  Y+  +RPVE+    + V  ++ ++Q+ ++DE NQI+   LW+R IW+D  
Sbjct: 32  QKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAY 91

Query: 95  LRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIF 154
           L WD  +YDG++++R+P+D +W+PDIVLYN A  +      T  +L+Y+G+ITW  PAI 
Sbjct: 92  LTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAIT 151

Query: 155 KSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASGY 214
           KSSC +D+T+FPFD+Q C+L FGSWTY+  ++D+       D++DF E+ EWE+      
Sbjct: 152 KSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAV 211

Query: 215 KHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTL 274
           K+ I Y CC E Y D+T++  ++R   FY +NL+IPC+ ISFL  L FYLP+  GEKV+L
Sbjct: 212 KNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSL 271

Query: 275 CISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTT 334
            +++LL++TVF L++ E +P+ S  VPL+G+Y + TM  +T S  +T+ V+NIH+     
Sbjct: 272 GVTILLAMTVFQLMVAEIMPA-SENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEA 330

Query: 335 HTMPRWVKTVFLKLLPQVLLM----RWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPR 390
             +P W + V LK + +VL +       L        D + +  ++ P     A+  +  
Sbjct: 331 RPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAARNKDL 390

Query: 391 HLKECFHCHKSNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETK 450
             K+  +    N+L    +           E   +  + + +  ++++IA+ +K H  T 
Sbjct: 391 SRKKDMNKRLKNDLGCQGKNPQ--------EAESYCAQYKVLTRNIEYIAKCLKDHKATN 442

Query: 451 EVEDDWKYVAMVVDRVFLWVFIIV 474
               +WK VA V+DR F+W+F I+
Sbjct: 443 SKGSEWKKVAKVIDRFFMWIFFIM 466


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  332 bits (851), Expect = 5e-91
 Identities = 186/480 (38%), Positives = 267/480 (55%), Gaps = 27/480 (5%)

Query: 27  GCVGCATEERLFHKLFSH--YNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNL 84
           G  G   EERL   LF    YN+ +RPV +  + V V   + ++ L ++ EV + + TN+
Sbjct: 18  GSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNV 77

Query: 85  WLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNG 144
           W+ H W D +L+W+  E+  I  LR+P D +W P+IVL NN  G FQ+      L+ + G
Sbjct: 78  WIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYG 137

Query: 145 MITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSK---------- 194
            + W PPAIF+SSCP+ +T+FPFD QNCSLKF S  Y   EI L +              
Sbjct: 138 FVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEW 197

Query: 195 --VDMNDFWENSEWEIIDASGYKH-DIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPC 251
             +D   F EN EWEI+      + D +         DIT+   IRR P+FY IN+++PC
Sbjct: 198 IIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPC 257

Query: 252 LFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTM 311
           + ISF+  LVFYLP+D GEK ++ ISVLL+ +VFLL+I++ +P+TS+ +PL+G++LLF M
Sbjct: 258 VLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGM 317

Query: 312 IFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVP 371
           + VT+ +V+ V VLNIH+RTP+TH +   VK +FL+ LP++L M  P +          P
Sbjct: 318 VLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAE------DGPSP 371

Query: 372 RGLARRPAKGKLASHGEPRHL---KECFHCHKSNELATSKRRLS---HQPLQWVVENSEH 425
             L RR +     S  E   L   +      K +E     RRL+     P        E 
Sbjct: 372 GALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQEL 431

Query: 426 SPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQ 485
             E++  ++   FI  +M+  N   E +D W  VA  VDR+ L+V   V V GTA +FLQ
Sbjct: 432 FNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQ 491


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  331 bits (848), Expect = 1e-90
 Identities = 175/490 (35%), Positives = 278/490 (56%), Gaps = 30/490 (6%)

Query: 16  LWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDE 75
           +WL +        +    + +L+ +L  +YN   RPV N S P+TV+F +++ Q+ +VDE
Sbjct: 8   VWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDE 67

Query: 76  VNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGK 135
            NQ++ TN+WL+  W D+ L+W+  EY G++T+R P  +IWKPDI+LYN+A   F     
Sbjct: 68  KNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFH 127

Query: 136 TKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKV 195
           T  L+  +G   + PP IFKSSC +D+ +FPFD Q+C LKFGSW+Y    +DL +   + 
Sbjct: 128 TNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQM--QEA 185

Query: 196 DMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFIS 255
           D++ +  N EW+++   G + +  Y CC+E Y D+T++  +RR  ++Y +NL+IPC+ IS
Sbjct: 186 DISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLIS 245

Query: 256 FLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVT 315
            L +LVF LP+D GEK++L I+VLLSLTVF+L++ E +P+TS  VPL+ +Y   TMI V 
Sbjct: 246 ALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVG 305

Query: 316 LSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLA 375
           LS+VVTV VL  H+  P    MP+W + + L      L M+ P       G D V     
Sbjct: 306 LSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRP-------GEDKVRPACQ 358

Query: 376 RRPAKGKL------------ASHGEPRHL----KECFHCHKSNELATSKRRLSHQP---- 415
            +  +  L            AS+G   ++     +  HC  + +      R++  P    
Sbjct: 359 HKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDE 418

Query: 416 -LQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIV 474
            L    +  E  P++  ++  V++IA   +  +E++ V  +WK+ A VVDR+ L  F + 
Sbjct: 419 HLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVF 478

Query: 475 CVFGTAGLFL 484
            +  T G+ +
Sbjct: 479 TIICTIGILM 488


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  329 bits (844), Expect = 3e-90
 Identities = 179/491 (36%), Positives = 273/491 (55%), Gaps = 47/491 (9%)

Query: 23  PFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMET 82
           P   G  G   E RL  KLFS Y+  +RP   V D V V   + + QL +++E ++ M T
Sbjct: 16  PLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMST 75

Query: 83  NLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKY 142
            ++L   W DY+L WDP E+DGI++LR+ A+ +W PD+VL NN  G+F V      ++  
Sbjct: 76  KVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSS 135

Query: 143 NGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLI-IGS-------- 193
           +G + W PP I++SSC + +T+FPFD QNC++ F S++YD +E+ L   +G         
Sbjct: 136 DGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEI 195

Query: 194 KVDMNDFWENSEWEII-----------DASGYKHDIKYNCCEEIYTDITYSFYIRRLPMF 242
            +    F EN +WEII           D  G +        E    ++ +   IRR P+F
Sbjct: 196 HIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGR--------EGQRQEVIFYLIIRRKPLF 247

Query: 243 YTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPL 302
           Y +N+I PC+ I+ L + VFYLP D GEK+ L I  LL+LTVFLL++ + +P TSL VP+
Sbjct: 248 YLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPI 307

Query: 303 VGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKT 362
           + +YL+FTM+ VT S++++V VLN+H+R+P TH MP WV+ +F+  LP  L ++ P  + 
Sbjct: 308 IIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPE- 366

Query: 363 RGTGSDAVPRGLARRPAKGKLASHGEPRHLKECFHCHKSNELATSK-----RRLSHQPLQ 417
                    R L   P        G  R   E F     ++    K       LS   L+
Sbjct: 367 ---------RDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLR 417

Query: 418 WVVENSEHS----PEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFII 473
             ++    +    PE+ +V++S+ +IA  ++   +   +++DW++VAMVVDR+FLW FII
Sbjct: 418 RFIDGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFII 477

Query: 474 VCVFGTAGLFL 484
               GT  +FL
Sbjct: 478 FTSVGTLVIFL 488


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  302 bits (773), Expect = 5e-82
 Identities = 157/452 (34%), Positives = 242/452 (53%), Gaps = 33/452 (7%)

Query: 36  RLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKL 95
           +LF  LF++Y   +RPV +    + V  EV ++Q+ ++DE NQ++   LW+R  W D  L
Sbjct: 32  KLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYL 91

Query: 96  RWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFK 155
           RWDP  Y G++ +R+P+  +W+PDIVLYN A         T  +L+++G + W  PAI +
Sbjct: 92  RWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITR 151

Query: 156 SSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASGYK 215
           SSC +D+  FPFD Q+C L FGSWT+   ++D+   G+   + DF EN EW ++     +
Sbjct: 152 SSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARR 211

Query: 216 HDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLC 275
             + Y CC E Y D+T++  +RR    Y  NL++PC+ IS L  L F+LP+D GEKV+L 
Sbjct: 212 RVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLG 271

Query: 276 ISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTH 335
           ++VLL+LTVF L++ E++P     VPL+G+Y + TM  VT S  +T+ ++N+HY  P+  
Sbjct: 272 VTVLLALTVFQLLLAESMPPAE-SVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVR 330

Query: 336 TMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPRHLKEC 395
            +P W + + L  L + L +R      RG      P G +R P         E       
Sbjct: 331 PVPAWARALLLGHLARGLCVR-----ERGE-----PCGQSRPPELSPSPQSPEGGAGPPA 380

Query: 396 FHCHKSNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDD 455
             CH+   L   +  L H                      V  IA   +SH   +   +D
Sbjct: 381 GPCHEPRCLCRQEALLHH----------------------VATIANTFRSHRAAQRCHED 418

Query: 456 WKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPL 487
           WK +A V+DR FL +F  + +  +  + +Q L
Sbjct: 419 WKRLARVMDRFFLAIFFSMALVMSLLVLVQAL 450


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  290 bits (743), Expect = 2e-78
 Identities = 167/471 (35%), Positives = 254/471 (53%), Gaps = 29/471 (6%)

Query: 29  VGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRH 88
           VG   E RL+H LF++Y+   RPV    D VT+  +V +T L +++E  + + T++W+  
Sbjct: 19  VGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGI 78

Query: 89  IWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITW 148
            W DY+L +   ++ GIETLRVP++ +W P+IVL NN  G F V      L+   G +TW
Sbjct: 79  DWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTW 138

Query: 149 TPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDL---------LIIGSKVDMND 199
            PPAI++S C +++T+FPFD QNCSL F S TY+  E++           I    +D   
Sbjct: 139 LPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEA 198

Query: 200 FWENSEWEIIDASGYKHDIKYNCCE-EIYTDITYSFYIRRLPMFYTINLIIPCLFISFLT 258
           + EN EW I    G          +    TD+ YS  IRR P+FY IN+I+PC+ IS L 
Sbjct: 199 YTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLV 258

Query: 259 VLVFYLPSDC-GEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLS 317
           +L ++LP+   G+K T+ I+VLL+ TVFL +I + IP TSL VPL+G +L+F M+  TL 
Sbjct: 259 LLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLI 318

Query: 318 IVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARR 377
           ++  V VLN+  RTPTTH M   ++ V L+LLP++L            GS   P      
Sbjct: 319 VMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLL------------GSPPPPEAPRAA 366

Query: 378 PAKGKLASHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWVVENSEH----SPEVEDVI 433
               + +S G     +E       +EL    +R  H+   W     +     +PEV   +
Sbjct: 367 SPPRRASSVGLLLRAEELILKKPRSELVFEGQR--HRQGTWTAAFCQSLGAAAPEVRCCV 424

Query: 434 NSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFL 484
           ++V F+AE+ +    T E   DW  +   +D +  W  +++   G++ +FL
Sbjct: 425 DAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFL 475


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  281 bits (720), Expect = 7e-76
 Identities = 174/498 (34%), Positives = 260/498 (52%), Gaps = 28/498 (5%)

Query: 10  LHGGLC-LWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAIT 68
           +HGG   L L +      G  G   EERL   L  +Y+  +RP E  SD V V  ++ +T
Sbjct: 1   MHGGQGPLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLT 60

Query: 69  QLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVG 128
            L +++E  + + TN+W+   W DY+LRWDP +Y+G+  LRVP+  +W+PDIVL NN  G
Sbjct: 61  NLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDG 120

Query: 129 DFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDL 188
            F+V      L+  +G I W PPAIF+S+C + +T+FPFD QNCSL F S TY   EIDL
Sbjct: 121 VFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDL 180

Query: 189 LIIGSK--------VDMNDFWENSEWEIID-ASGYKHDIKYNCCEEIYTDITYSFYIRRL 239
            +            +D   F EN EW I    +    D      E  +  + +   I+R 
Sbjct: 181 QLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRK 240

Query: 240 PMFYTINLIIPCLFISFLTVLVFYLPSDC-GEKVTLCISVLLSLTVFLLVITETIPSTSL 298
           P+FY IN+I PC+ IS + +L+ +LP+   G+K T+ I+VLL+ TVFL ++ + +P TS 
Sbjct: 241 PLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQ 300

Query: 299 VVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWP 358
            VPL+ +YL F ++   L +V  V VLN+  R+P TH+M R V+ VFL+LLPQ+L M   
Sbjct: 301 AVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMH-- 358

Query: 359 LDKTRGTGSDAVPRGLAR--RPAKGKLASHGE------PRHLKECFHCHKSNELATSKRR 410
               R     AV    +R    + G   + GE      PR         +   +A +  +
Sbjct: 359 ---VRPLAPAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALEK 415

Query: 411 LSHQP----LQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRV 466
           L   P     Q+     + +P ++  + +   IA      +      ++W  V  V+DRV
Sbjct: 416 LEKGPELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRV 475

Query: 467 FLWVFIIVCVFGTAGLFL 484
                + + + GTAG+FL
Sbjct: 476 CFLAMLSLFICGTAGIFL 493


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  232 bits (592), Expect = 5e-61
 Identities = 130/376 (34%), Positives = 205/376 (54%), Gaps = 30/376 (7%)

Query: 130 FQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLL 189
           F     T  L+  +G   + PP IFKSSC +D+ +FPFD Q+C LKFGSW+Y    +DL 
Sbjct: 32  FDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQ 91

Query: 190 IIGSKVDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLII 249
           +   + D++ +  N EW+++   G + +  Y CC+E Y D+T++  +RR  ++Y +NL+I
Sbjct: 92  M--QEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLI 149

Query: 250 PCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLF 309
           PC+ IS L +LVF LP+D GEK++L I+VLLSLTVF+L++ E +P+TS  VPL+ +Y   
Sbjct: 150 PCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAS 209

Query: 310 TMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDA 369
           TMI V LS+VVTV VL  H+  P    MP+W + + L      L M+ P       G D 
Sbjct: 210 TMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRP-------GEDK 262

Query: 370 VPRGLARRPAKGKL------------ASHGEPRHL----KECFHCHKSNELATSKRRLSH 413
           V      +  +  L            AS+G   ++     +  HC  + +      R++ 
Sbjct: 263 VRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMAC 322

Query: 414 QP-----LQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFL 468
            P     L    +  E  P++  ++  V++IA   +  +E++ V  +WK+ A VVDR+ L
Sbjct: 323 SPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCL 382

Query: 469 WVFIIVCVFGTAGLFL 484
             F +  +  T G+ +
Sbjct: 383 MAFSVFTIICTIGILM 398


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  219 bits (557), Expect = 6e-57
 Identities = 125/447 (27%), Positives = 230/447 (51%), Gaps = 32/447 (7%)

Query: 36  RLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKL 95
           RL   L ++Y + +RPV +   P TV  +V +  + NVDE NQ++ T +W R  W D  L
Sbjct: 42  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 101

Query: 96  RWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKAL----LKYNGMITWTPP 151
           +W+P ++D I  L +P D IW PDI+     + +F   GK+  +    +++ G +    P
Sbjct: 102 QWNPEDFDNITKLSIPTDSIWVPDIL-----INEFVDVGKSPNIPYVYIRHQGEVQNYKP 156

Query: 152 AIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLI--IGSKV--DMNDFWENSEWE 207
               ++C +DI  FPFD QNCSL F SW +   +I++ +  +  KV  D + F    EWE
Sbjct: 157 LQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWE 216

Query: 208 IIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSD 267
           ++    Y  +         Y ++ +   IRR P+FY ++L++P +F+  + ++ FYLP +
Sbjct: 217 LLGVLPYFREFSMES-SNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPN 275

Query: 268 CGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNI 327
            GE+V+  I++LL  +VFL+++++T+P+T++  PL+G Y +  M  + +S+  T+F++ +
Sbjct: 276 SGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRL 335

Query: 328 HYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHG 387
            ++      +P W++ + L+ +  +L +R      R       P   ++       ++ G
Sbjct: 336 VHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQR-------PPATSQATKTDDCSAMG 388

Query: 388 EPRHLKECFHCHKSNELATSKR-RLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSH 446
                  C H     +   S R R S  P        E S  V  ++  +  I + ++  
Sbjct: 389 -----NHCSHMGGPQDFEKSPRDRCSPPP-----PPREASLAVCGLLQELSSIRQFLEKR 438

Query: 447 NETKEVEDDWKYVAMVVDRVFLWVFII 473
           +E +EV  DW  V  V+D++   ++++
Sbjct: 439 DEIREVARDWLRVGSVLDKLLFHIYLL 465


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  219 bits (557), Expect = 6e-57
 Identities = 125/447 (27%), Positives = 230/447 (51%), Gaps = 32/447 (7%)

Query: 36  RLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKL 95
           RL   L ++Y + +RPV +   P TV  +V +  + NVDE NQ++ T +W R  W D  L
Sbjct: 21  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 80

Query: 96  RWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKAL----LKYNGMITWTPP 151
           +W+P ++D I  L +P D IW PDI+     + +F   GK+  +    +++ G +    P
Sbjct: 81  QWNPEDFDNITKLSIPTDSIWVPDIL-----INEFVDVGKSPNIPYVYIRHQGEVQNYKP 135

Query: 152 AIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLI--IGSKV--DMNDFWENSEWE 207
               ++C +DI  FPFD QNCSL F SW +   +I++ +  +  KV  D + F    EWE
Sbjct: 136 LQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWE 195

Query: 208 IIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSD 267
           ++    Y  +         Y ++ +   IRR P+FY ++L++P +F+  + ++ FYLP +
Sbjct: 196 LLGVLPYFREFSMES-SNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPN 254

Query: 268 CGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNI 327
            GE+V+  I++LL  +VFL+++++T+P+T++  PL+G Y +  M  + +S+  T+F++ +
Sbjct: 255 SGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRL 314

Query: 328 HYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHG 387
            ++      +P W++ + L+ +  +L +R      R       P   ++       ++ G
Sbjct: 315 VHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQR-------PPATSQATKTDDCSAMG 367

Query: 388 EPRHLKECFHCHKSNELATSKR-RLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSH 446
                  C H     +   S R R S  P        E S  V  ++  +  I + ++  
Sbjct: 368 -----NHCSHMGGPQDFEKSPRDRCSPPP-----PPREASLAVCGLLQELSSIRQFLEKR 417

Query: 447 NETKEVEDDWKYVAMVVDRVFLWVFII 473
           +E +EV  DW  V  V+D++   ++++
Sbjct: 418 DEIREVARDWLRVGSVLDKLLFHIYLL 444


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  203 bits (517), Expect = 3e-52
 Identities = 127/479 (26%), Positives = 228/479 (47%), Gaps = 64/479 (13%)

Query: 36  RLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKL 95
           RL   L ++Y + +RPV +   P TV  +V +  + NVDE NQ++ T +W R  W D  L
Sbjct: 42  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 101

Query: 96  RWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKAL----LKYNGMITWTPP 151
           +W+P ++D I  L +P D IW PDI+     + +F   GK+  +    +++ G +    P
Sbjct: 102 QWNPEDFDNITKLSIPTDSIWVPDIL-----INEFVDVGKSPNIPYVYIRHQGEVQNYKP 156

Query: 152 AIFKSSCPMDITFFPFDHQNCSLKFGSW--TYDKAEIDLLIIGSKV--DMNDFWENSEWE 207
               ++C +DI  FPFD QNCSL F SW  T     I L  +  KV  D + F    EWE
Sbjct: 157 LQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWE 216

Query: 208 IIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSD 267
           ++    Y  +         Y ++ +   IRR P+FY ++L++P +F+  + ++ FYLP +
Sbjct: 217 LLGVLPYFREFSME-SSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPN 275

Query: 268 CGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGE---------------------- 305
            GE+V+  I++LL  +VFL+++++T+P+T++  PL+G+                      
Sbjct: 276 SGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVS 335

Query: 306 ----------YLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLM 355
                     Y +  M  + +S+  T+F++ + ++      +P W++ + L+ +  +L +
Sbjct: 336 LASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCL 395

Query: 356 RWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPRHLKECFHCHKSNELATSKR-RLSHQ 414
           R      R       P   ++       ++ G       C H     +   S R R S  
Sbjct: 396 REQSTSQR-------PPATSQATKTDDCSAMG-----NHCSHMGGPQDFEKSPRDRCSPP 443

Query: 415 PLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFII 473
           P        E S  V  ++  +  I + ++  +E +EV  DW  V  V+D++   ++++
Sbjct: 444 P-----PPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLL 497


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  179 bits (453), Expect = 7e-45
 Identities = 102/312 (32%), Positives = 167/312 (53%), Gaps = 28/312 (8%)

Query: 194 KVDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLF 253
           + D++ +  N EW+++   G + +  Y CC+E Y D+T++  +RR  ++Y +NL+IPC+ 
Sbjct: 3   EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVL 62

Query: 254 ISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIF 313
           IS L +LVF LP+D GEK++L I+VLLSLTVF+L++ E +P+TS  VPL+ +Y   TMI 
Sbjct: 63  ISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMII 122

Query: 314 VTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRG 373
           V LS+VVTV VL  H+  P    MP+W + + L      L M+ P       G D V   
Sbjct: 123 VGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRP-------GEDKVRPA 175

Query: 374 LARRPAKGKL------------ASHGEPRHL----KECFHCHKSNELATSKRRLSHQP-- 415
              +  +  L            AS+G   ++     +  HC  + +      R++  P  
Sbjct: 176 CQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTH 235

Query: 416 ---LQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFI 472
              L    +  E  P++  ++  V++IA   +  +E++ V  +WK+ A VVDR+ L  F 
Sbjct: 236 DEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFS 295

Query: 473 IVCVFGTAGLFL 484
           +  +  T G+ +
Sbjct: 296 VFTIICTIGILM 307


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  162 bits (410), Expect = 6e-40
 Identities = 94/306 (30%), Positives = 161/306 (52%), Gaps = 17/306 (5%)

Query: 50  RPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLR 109
           RPV N+S P  V+   A++ + +V+E   ++ + LWL  +W++  + W+P E +GI  + 
Sbjct: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129

Query: 110 VPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDH 169
           + A  +W PDI +      D   +G T A +   G I +  P    S C +DI +FPFD 
Sbjct: 130 MAAKNLWLPDIFIIELMDVDKTPKGLT-AYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQ 188

Query: 170 QNCSLKFGSWTYDKAEIDLLIIGSKVDM--------NDFWENSEWEIIDASGYKHDIKYN 221
           QNC+L F S+ Y    +D +++  + ++        N    + EWE++  S  K   K +
Sbjct: 189 QNCTLTFSSFLY---TVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLS--KATAKLS 243

Query: 222 CCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLS 281
               +Y  I +   IRR P  Y INL++P  F+  +  L FYLP   G +V   I++LL 
Sbjct: 244 RGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLG 303

Query: 282 LTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLN-IHYRTPTTHTMPRW 340
             VFLL++++ +P++    PL+G Y    +  +  S++ T+F+ + +H  T     +PRW
Sbjct: 304 YNVFLLMMSDLLPTSG--TPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRW 361

Query: 341 VKTVFL 346
           + ++ L
Sbjct: 362 LHSLLL 367


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  158 bits (399), Expect = 1e-38
 Identities = 91/321 (28%), Positives = 164/321 (51%), Gaps = 16/321 (4%)

Query: 16  LWLCVFTPFFKGCVGCAT----EERLFH---KLFSHYNQFIRPVENVSDPVTVHFEVAIT 68
           LW C+      G +   T    +  L+H   +L   Y++ +RPV N +   TV+ ++ + 
Sbjct: 9   LWACILVA--AGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVH 66

Query: 69  QLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVG 128
            + +VD  NQI++T++W + +WND  L W+   +D I  + +P   IW PDI++ N  V 
Sbjct: 67  AILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII-NEFVD 125

Query: 129 DFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDL 188
             +        +  +G I    P    S+C ++   FPFD QNCSL F S  +   ++DL
Sbjct: 126 IERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDL 185

Query: 189 LIIGSKVDMND----FWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYT 244
             + S  D+      F  +SEWE++  S     ++ +     +  I ++  +RR P+ Y 
Sbjct: 186 AFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGG--FAQIQFNVVMRRHPLVYV 243

Query: 245 INLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVG 304
           ++L+IP +F+  + +  FYLP +C  ++    SVL+  TVF + ++  +P +    PL+G
Sbjct: 244 VSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIG 303

Query: 305 EYLLFTMIFVTLSIVVTVFVL 325
            +    M F+ LS+  ++ ++
Sbjct: 304 HFFTICMAFLVLSLAKSIVLV 324


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  157 bits (397), Expect = 2e-38
 Identities = 92/306 (30%), Positives = 155/306 (50%), Gaps = 17/306 (5%)

Query: 50  RPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLR 109
           RP  N S P  V+    ++ +  VD   Q++ + LW+  +W++  + W+P E  GI  L 
Sbjct: 55  RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114

Query: 110 VPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDH 169
           V A+ +W PDI +  +   D    G T A +   G I +  P    S C +DI +FPFD 
Sbjct: 115 VLAENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYFPFDQ 173

Query: 170 QNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENS--------EWEIIDASGYKHDIKYN 221
           QNC+  F S+ Y    +D +++G   ++ +  + S        EWE++  +  K   K +
Sbjct: 174 QNCTFTFSSFLYT---VDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGIN--KATPKMS 228

Query: 222 CCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLS 281
               +Y  I +   IRR P  Y INL++P  F+  +  L FYLP++   +    I++LL 
Sbjct: 229 MGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLG 288

Query: 282 LTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLN-IHYRTPTTHTMPRW 340
             VFLL++ + +P++    PL+  Y    +  + +S++ TVF+   +H  T     MPRW
Sbjct: 289 YNVFLLMMNDLLPASG--TPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRW 346

Query: 341 VKTVFL 346
           + ++ L
Sbjct: 347 LHSLLL 352


>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 70/287 (24%), Positives = 124/287 (43%), Gaps = 19/287 (6%)

Query: 43  SHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEY 102
           S Y+  IRP      PV V   + I    +V E       N++LR  WND +L +     
Sbjct: 56  SGYDARIRP-NFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPD 114

Query: 103 DGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKY--NGMITWTPPAIFKSSCPM 160
           D ++      D IWKPD+   N    +F        LL+   NG + ++       SCPM
Sbjct: 115 DSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPM 174

Query: 161 DITFFPFDHQNCSLKFGSWTYDKAEIDL-------LIIGSKVDMNDFWENSEWEIIDASG 213
           D+  FP D Q C+++  S+ Y   ++         + +   + +  F    E E+   + 
Sbjct: 175 DLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTK 234

Query: 214 YKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCG-EKV 272
           + +  K+ C E         F++ R   +Y I + IP L I  L+ + F++  D    +V
Sbjct: 235 HYNTGKFTCIE-------VKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARV 287

Query: 273 TLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIV 319
            L I+ +L++T        ++P  S  V  +  ++   ++FV  +++
Sbjct: 288 ALGITTVLTMTTQSSGSRASLPKVS-YVKAIDIWMAVCLLFVFAALL 333


>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 70/287 (24%), Positives = 124/287 (43%), Gaps = 19/287 (6%)

Query: 43  SHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEY 102
           S Y+  IRP      PV V   + I    +V E       N++LR  WND +L +     
Sbjct: 56  SGYDARIRP-NFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPD 114

Query: 103 DGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKY--NGMITWTPPAIFKSSCPM 160
           D ++      D IWKPD+   N    +F        LL+   NG + ++       SCPM
Sbjct: 115 DSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPM 174

Query: 161 DITFFPFDHQNCSLKFGSWTYDKAEIDL-------LIIGSKVDMNDFWENSEWEIIDASG 213
           D+  FP D Q C+++  S+ Y   ++         + +   + +  F    E E+   + 
Sbjct: 175 DLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTK 234

Query: 214 YKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCG-EKV 272
           + +  K+ C E         F++ R   +Y I + IP L I  L+ + F++  D    +V
Sbjct: 235 HYNTGKFTCIE-------VKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARV 287

Query: 273 TLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIV 319
            L I+ +L++T        ++P  S  V  +  ++   ++FV  +++
Sbjct: 288 ALGITTVLTMTTQSSGSRASLPKVS-YVKAIDIWMAVCLLFVFAALL 333


>gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]
          Length = 452

 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 69/287 (24%), Positives = 124/287 (43%), Gaps = 19/287 (6%)

Query: 43  SHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEY 102
           S Y+  IRP      PV V   + I    ++ E       N++LR  WND +L +     
Sbjct: 56  SGYDARIRP-NFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDSRLAYSEYPD 114

Query: 103 DGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKY--NGMITWTPPAIFKSSCPM 160
           D ++      D IWKPD+   N    +F        LL+   NG + ++       SCPM
Sbjct: 115 DSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPM 174

Query: 161 DITFFPFDHQNCSLKFGSWTYDKAEIDL-------LIIGSKVDMNDFWENSEWEIIDASG 213
           D+  FP D Q C+++  S+ Y   ++         + +   + +  F    E E+   + 
Sbjct: 175 DLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTK 234

Query: 214 YKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCG-EKV 272
           + +  K+ C E         F++ R   +Y I + IP L I  L+ + F++  D    +V
Sbjct: 235 HYNTGKFTCIE-------VKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARV 287

Query: 273 TLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIV 319
            L I+ +L++T        ++P  S  V  +  ++   ++FV  +++
Sbjct: 288 ALGITTVLTMTTQSSGSRASLPKVS-YVKAIDIWMAVCLLFVFAALL 333


>gi|4504023 glycine receptor, beta [Homo sapiens]
          Length = 497

 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 77/301 (25%), Positives = 128/301 (42%), Gaps = 32/301 (10%)

Query: 37  LFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLR 96
           + ++L   Y+  IRP      PV V   + I    ++ E       N++LR  WND +L+
Sbjct: 59  ILNRLLVSYDPRIRP-NFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLK 117

Query: 97  WDPMEYDGIETLRVPADK---IWKPDIVLYNNAVGDFQVEGKTKALLKY--NGMITWTPP 151
             P ++ G + L V       +WKPD+   N    +F    +   LL    +G +  +  
Sbjct: 118 L-PSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMR 176

Query: 152 AIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDA 211
                SCP+D+T FP D Q C ++  S+ Y           +  D+   W++ +   ++ 
Sbjct: 177 LSITLSCPLDLTLFPMDTQRCKMQLESFGY-----------TTDDLRFIWQSGDPVQLEK 225

Query: 212 SGY------KHDIKYNCCEE------IYTDITYSFYIRRLPMFYTINLIIPCLFISFLTV 259
                    K DI+Y  C +       YT +   F +RR   FY + +  P L I  L+ 
Sbjct: 226 IALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSW 285

Query: 260 LVFYL-PSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSI 318
           L F++ P     +V L I  +LSL      +   +P  S V  L   +L+  ++F   S+
Sbjct: 286 LSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKAL-DVWLIACLLFGFASL 344

Query: 319 V 319
           V
Sbjct: 345 V 345


>gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]
          Length = 449

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 68/270 (25%), Positives = 114/270 (42%), Gaps = 24/270 (8%)

Query: 43  SHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEY 102
           S Y+  IRP      PV V   + I    ++ E       N++LR  WND +L +     
Sbjct: 55  SGYDARIRP-NFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPD 113

Query: 103 DGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKY--NGMITWTPPAIFKSSCPM 160
           D ++      D IWKPD+   N    +F        LL+   NG + ++       SCPM
Sbjct: 114 DSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPM 173

Query: 161 DITFFPFDHQNCSLKFGSWTY----------DKAEIDLLIIGSKVDMNDFWENSEWEIID 210
           D+  FP D Q C ++  S+ Y          D+A +    +   + +  F    E ++  
Sbjct: 174 DLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQ---VAEGLTLPQFLLKEEKDLRY 230

Query: 211 ASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCG- 269
            + + +  K+ C E         F++ R   +Y I + IP L I  L+ + F++  D   
Sbjct: 231 CTKHYNTGKFTCIE-------VRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAP 283

Query: 270 EKVTLCISVLLSLTVFLLVITETIPSTSLV 299
            +V L I+ +L++T        ++P  S V
Sbjct: 284 ARVALGITTVLTMTTQSSGSRASLPKVSYV 313


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.140    0.453 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,934,668
Number of Sequences: 37866
Number of extensions: 835007
Number of successful extensions: 2693
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 2502
Number of HSP's gapped (non-prelim): 112
length of query: 494
length of database: 18,247,518
effective HSP length: 106
effective length of query: 388
effective length of database: 14,233,722
effective search space: 5522684136
effective search space used: 5522684136
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.