Search of human proteins with 46358428

Search of human proteins with 46358428

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46358428 selective LIM binding factor homolog [Homo sapiens]
         (1749 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46358428 selective LIM binding factor homolog [Homo sapiens]      3522   0.0  
gi|46409657 WD repeat domain 56 [Homo sapiens]                         62   5e-09
gi|16554625 WD repeat domain 10 isoform 4 [Homo sapiens]               54   1e-06
gi|16554619 WD repeat domain 10 isoform 3 [Homo sapiens]               54   1e-06
gi|16554623 WD repeat domain 10 isoform 2 [Homo sapiens]               54   1e-06
gi|16554621 WD repeat domain 10 isoform 1 [Homo sapiens]               54   2e-06
gi|23199987 WD repeat domain 5B [Homo sapiens]                         52   5e-06
gi|41281447 intraflagellar transport 140 [Homo sapiens]                49   3e-05
gi|55743151 WD repeat domain 19 [Homo sapiens]                         49   3e-05
gi|56243599 WD repeat domain 35 isoform 2 [Homo sapiens]               46   4e-04
gi|55743161 WD repeat domain 35 isoform 1 [Homo sapiens]               46   4e-04
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          44   0.002
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]          44   0.002
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]          44   0.002
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]            44   0.002
gi|19913367 transducin beta-like 1Y [Homo sapiens]                     43   0.003
gi|19913365 transducin beta-like 1Y [Homo sapiens]                     43   0.003
gi|15150805 transducin beta-like 1Y [Homo sapiens]                     43   0.003
gi|5031601 actin related protein 2/3 complex subunit 1B [Homo sa...    42   0.005
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is...    42   0.007
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i...    42   0.007
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    42   0.007
gi|110347568 centrosomal protein 152kDa [Homo sapiens]                 42   0.007
gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens]               41   0.012
gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens]               41   0.012
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [...    39   0.044
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [...    39   0.044
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [...    39   0.058
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H...    39   0.058
gi|212276078 leucine rich repeat (in FLII) interacting protein 1...    37   0.17 

>gi|46358428 selective LIM binding factor homolog [Homo sapiens]
          Length = 1749

 Score = 3522 bits (9133), Expect = 0.0
 Identities = 1749/1749 (100%), Positives = 1749/1749 (100%)

Query: 1    MHLKHLRTLLSPQDGAAKVTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADM 60
            MHLKHLRTLLSPQDGAAKVTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADM
Sbjct: 1    MHLKHLRTLLSPQDGAAKVTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADM 60

Query: 61   KYGRKSYMVKGMAFSPDSTKIAIGQTDNIIYVYKIGEDWGDKKVICNKFIQTSAVTCLQW 120
            KYGRKSYMVKGMAFSPDSTKIAIGQTDNIIYVYKIGEDWGDKKVICNKFIQTSAVTCLQW
Sbjct: 61   KYGRKSYMVKGMAFSPDSTKIAIGQTDNIIYVYKIGEDWGDKKVICNKFIQTSAVTCLQW 120

Query: 121  PAEYIIVFGLAEGKVRLANTKTNKSSTIYGTESYVVSLTTNCSGKGILSGHADGTIVRYF 180
            PAEYIIVFGLAEGKVRLANTKTNKSSTIYGTESYVVSLTTNCSGKGILSGHADGTIVRYF
Sbjct: 121  PAEYIIVFGLAEGKVRLANTKTNKSSTIYGTESYVVSLTTNCSGKGILSGHADGTIVRYF 180

Query: 181  FDDEGSGESQGKLVNHPCPPYALAWATNSIVAAGCDRKIVAYGKEGHMLQTFDYSRDPQE 240
            FDDEGSGESQGKLVNHPCPPYALAWATNSIVAAGCDRKIVAYGKEGHMLQTFDYSRDPQE
Sbjct: 181  FDDEGSGESQGKLVNHPCPPYALAWATNSIVAAGCDRKIVAYGKEGHMLQTFDYSRDPQE 240

Query: 241  REFTTAVSSPGGQSVVLGSYDRLRVFNWIPRRSIWEEAKPKEITNLYTITALAWKRDGSR 300
            REFTTAVSSPGGQSVVLGSYDRLRVFNWIPRRSIWEEAKPKEITNLYTITALAWKRDGSR
Sbjct: 241  REFTTAVSSPGGQSVVLGSYDRLRVFNWIPRRSIWEEAKPKEITNLYTITALAWKRDGSR 300

Query: 301  LCVGTLCGGVEQFDCCLRRSIYKNKFELTYVGPSQVIVKNLSSGTRVVLKSHYGYEVEEV 360
            LCVGTLCGGVEQFDCCLRRSIYKNKFELTYVGPSQVIVKNLSSGTRVVLKSHYGYEVEEV
Sbjct: 301  LCVGTLCGGVEQFDCCLRRSIYKNKFELTYVGPSQVIVKNLSSGTRVVLKSHYGYEVEEV 360

Query: 361  KILGKERYLVAHTSETLLLGDLNTNRLSEIAWQGSGGNEKYFFENENVCMIFNAGELTLV 420
            KILGKERYLVAHTSETLLLGDLNTNRLSEIAWQGSGGNEKYFFENENVCMIFNAGELTLV
Sbjct: 361  KILGKERYLVAHTSETLLLGDLNTNRLSEIAWQGSGGNEKYFFENENVCMIFNAGELTLV 420

Query: 421  EYGNNDTLGSVRTEFMNPHLISVRINERCQRGTEDNKKLAYLIDIKTIAIVDLIGGYNIG 480
            EYGNNDTLGSVRTEFMNPHLISVRINERCQRGTEDNKKLAYLIDIKTIAIVDLIGGYNIG
Sbjct: 421  EYGNNDTLGSVRTEFMNPHLISVRINERCQRGTEDNKKLAYLIDIKTIAIVDLIGGYNIG 480

Query: 481  TVSHESRVDWLELNETGHKLLFRDRKLRLHLYDIESCSKTMILNFCSYMQWVPGSDVLVA 540
            TVSHESRVDWLELNETGHKLLFRDRKLRLHLYDIESCSKTMILNFCSYMQWVPGSDVLVA
Sbjct: 481  TVSHESRVDWLELNETGHKLLFRDRKLRLHLYDIESCSKTMILNFCSYMQWVPGSDVLVA 540

Query: 541  QNRNSLCVWYNIEAPERVTMFTIRGDVIGLERGGGKTEVMVMEGVTTVAYTLDEGLIEFG 600
            QNRNSLCVWYNIEAPERVTMFTIRGDVIGLERGGGKTEVMVMEGVTTVAYTLDEGLIEFG
Sbjct: 541  QNRNSLCVWYNIEAPERVTMFTIRGDVIGLERGGGKTEVMVMEGVTTVAYTLDEGLIEFG 600

Query: 601  TAIDDGNYIRATAFLETLEMTPETEAMWKTLSKLALEARQLHIAERCFSALGQVAKARFL 660
            TAIDDGNYIRATAFLETLEMTPETEAMWKTLSKLALEARQLHIAERCFSALGQVAKARFL
Sbjct: 601  TAIDDGNYIRATAFLETLEMTPETEAMWKTLSKLALEARQLHIAERCFSALGQVAKARFL 660

Query: 661  HETNEIADQVSREYGGEGTDFYQVRARLAMLEKNYKLAEMIFLEQNAVEEAMGMYQELHR 720
            HETNEIADQVSREYGGEGTDFYQVRARLAMLEKNYKLAEMIFLEQNAVEEAMGMYQELHR
Sbjct: 661  HETNEIADQVSREYGGEGTDFYQVRARLAMLEKNYKLAEMIFLEQNAVEEAMGMYQELHR 720

Query: 721  WDECIAVAEAKGHPALEKLRRSYYQWLMDTQQEERAGELQESQGDGLAAISLYLKAGLPA 780
            WDECIAVAEAKGHPALEKLRRSYYQWLMDTQQEERAGELQESQGDGLAAISLYLKAGLPA
Sbjct: 721  WDECIAVAEAKGHPALEKLRRSYYQWLMDTQQEERAGELQESQGDGLAAISLYLKAGLPA 780

Query: 781  KAARLVLTREELLANTELVEHITAALIKGELYERAGDLFEKIHNPQKALECYRKGNAFMK 840
            KAARLVLTREELLANTELVEHITAALIKGELYERAGDLFEKIHNPQKALECYRKGNAFMK
Sbjct: 781  KAARLVLTREELLANTELVEHITAALIKGELYERAGDLFEKIHNPQKALECYRKGNAFMK 840

Query: 841  AVELARLAFPVEVVKLEEAWGDHLVQQKQLDAAINHYIEARCSIKAIEAALGARQWKKAI 900
            AVELARLAFPVEVVKLEEAWGDHLVQQKQLDAAINHYIEARCSIKAIEAALGARQWKKAI
Sbjct: 841  AVELARLAFPVEVVKLEEAWGDHLVQQKQLDAAINHYIEARCSIKAIEAALGARQWKKAI 900

Query: 901  YILDLQDRNTASKYYPLVAQHYASLQEYEIAEELYTKGDRTKDAIDMYTQAGRWEQAHKL 960
            YILDLQDRNTASKYYPLVAQHYASLQEYEIAEELYTKGDRTKDAIDMYTQAGRWEQAHKL
Sbjct: 901  YILDLQDRNTASKYYPLVAQHYASLQEYEIAEELYTKGDRTKDAIDMYTQAGRWEQAHKL 960

Query: 961  AMKCMRPEDVSVLYITQAQEMEKQGKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLV 1020
            AMKCMRPEDVSVLYITQAQEMEKQGKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLV
Sbjct: 961  AMKCMRPEDVSVLYITQAQEMEKQGKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLV 1020

Query: 1021 GKHHPDLLSDTHLHLGKELEAEGRLQEAEYHYLEAQEWKATVNMYRASGLWEEAYRVART 1080
            GKHHPDLLSDTHLHLGKELEAEGRLQEAEYHYLEAQEWKATVNMYRASGLWEEAYRVART
Sbjct: 1021 GKHHPDLLSDTHLHLGKELEAEGRLQEAEYHYLEAQEWKATVNMYRASGLWEEAYRVART 1080

Query: 1081 QGGANAHKHVAYLWAKSLGGEAAVRLLNKLGLLEAAVDHAADNCSFEFAFELSRLALKHK 1140
            QGGANAHKHVAYLWAKSLGGEAAVRLLNKLGLLEAAVDHAADNCSFEFAFELSRLALKHK
Sbjct: 1081 QGGANAHKHVAYLWAKSLGGEAAVRLLNKLGLLEAAVDHAADNCSFEFAFELSRLALKHK 1140

Query: 1141 TPEVHLKYAMFLEDEGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVA 1200
            TPEVHLKYAMFLEDEGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVA
Sbjct: 1141 TPEVHLKYAMFLEDEGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVA 1200

Query: 1201 EVLVGQARGALEEKDFQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPSQLEAL 1260
            EVLVGQARGALEEKDFQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPSQLEAL
Sbjct: 1201 EVLVGQARGALEEKDFQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPSQLEAL 1260

Query: 1261 QEEYEREATKKGARGVEGFVEQARHWEQAGEYSRAVDCYLKVRDSGNSGLAEKCWMKAAE 1320
            QEEYEREATKKGARGVEGFVEQARHWEQAGEYSRAVDCYLKVRDSGNSGLAEKCWMKAAE
Sbjct: 1261 QEEYEREATKKGARGVEGFVEQARHWEQAGEYSRAVDCYLKVRDSGNSGLAEKCWMKAAE 1320

Query: 1321 LSIKFLPPQRNMEVVLAVGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRV 1380
            LSIKFLPPQRNMEVVLAVGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRV
Sbjct: 1321 LSIKFLPPQRNMEVVLAVGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRV 1380

Query: 1381 AKELDPRYEDYVDQHYKEFLKNQGKVDSLVGVDVIAALDLYVEQGQWDKCIETATKQNYK 1440
            AKELDPRYEDYVDQHYKEFLKNQGKVDSLVGVDVIAALDLYVEQGQWDKCIETATKQNYK
Sbjct: 1381 AKELDPRYEDYVDQHYKEFLKNQGKVDSLVGVDVIAALDLYVEQGQWDKCIETATKQNYK 1440

Query: 1441 ILHKYVALYATHLIREGSSAQALALYVQHGAPANPQNFNIYKRIFTDMVSSPGTNCAEAY 1500
            ILHKYVALYATHLIREGSSAQALALYVQHGAPANPQNFNIYKRIFTDMVSSPGTNCAEAY
Sbjct: 1441 ILHKYVALYATHLIREGSSAQALALYVQHGAPANPQNFNIYKRIFTDMVSSPGTNCAEAY 1500

Query: 1501 HSWADLRDVLFNLCENLVKSSEANSPAHEEFKTMLLIAHYYATRSAAQSVKQLETVAARL 1560
            HSWADLRDVLFNLCENLVKSSEANSPAHEEFKTMLLIAHYYATRSAAQSVKQLETVAARL
Sbjct: 1501 HSWADLRDVLFNLCENLVKSSEANSPAHEEFKTMLLIAHYYATRSAAQSVKQLETVAARL 1560

Query: 1561 SVSLLRHTQLLPVDKAFYEAGIAAKAVGWDNMAFIFLNRFLDLTDAIEEGTLDGLDHSDF 1620
            SVSLLRHTQLLPVDKAFYEAGIAAKAVGWDNMAFIFLNRFLDLTDAIEEGTLDGLDHSDF
Sbjct: 1561 SVSLLRHTQLLPVDKAFYEAGIAAKAVGWDNMAFIFLNRFLDLTDAIEEGTLDGLDHSDF 1620

Query: 1621 QDTDIPFEVPLPAKQHVPEAEREEVRDWVLTVSMDQRLEQVLPRDERGAYEASLVAASTG 1680
            QDTDIPFEVPLPAKQHVPEAEREEVRDWVLTVSMDQRLEQVLPRDERGAYEASLVAASTG
Sbjct: 1621 QDTDIPFEVPLPAKQHVPEAEREEVRDWVLTVSMDQRLEQVLPRDERGAYEASLVAASTG 1680

Query: 1681 VRALPCLITGYPILRNKIEFKRPGKAANKDNWNKFLMAIKTSHSPVCQDVLKFISQWCGG 1740
            VRALPCLITGYPILRNKIEFKRPGKAANKDNWNKFLMAIKTSHSPVCQDVLKFISQWCGG
Sbjct: 1681 VRALPCLITGYPILRNKIEFKRPGKAANKDNWNKFLMAIKTSHSPVCQDVLKFISQWCGG 1740

Query: 1741 LPSTSFSFQ 1749
            LPSTSFSFQ
Sbjct: 1741 LPSTSFSFQ 1749


>gi|46409657 WD repeat domain 56 [Homo sapiens]
          Length = 777

 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 100/557 (17%), Positives = 217/557 (38%), Gaps = 92/557 (16%)

Query: 210 IVAAGCDRKIVAYGKEGHMLQTFDYSRDPQEREFTTAVSSPGGQSVVLGSYDRLRVFNWI 269
           I++AG D K   +   G  L    Y+  P E   T+   +P G+   +GS+  LR+ +  
Sbjct: 203 ILSAGEDCKYKVWDSYGRPL----YNSQPHEHPITSVAWAPDGELFAVGSFHTLRLCD-- 256

Query: 270 PRRSIWEEAKPKEITNLYTITALAWKRDGSRLCVGTLCGGVEQFDCCLRRSIYKNKFELT 329
             ++ W  A  K   N  +I  +AW  DG+++  G    G   F   + +      F++T
Sbjct: 257 --KTGWSYALEK--PNTGSIFNIAWSIDGTQI-AGACGNGHVVFAHVVEQHWEWKNFQVT 311

Query: 330 YVGPSQVIVKNLSSGTRVVLKSHYGYEVEEVKILGKERYLVAHTS-ETLLLGDLNTNRLS 388
                 + V+N+ +    +L+    +    +K      +LV  TS +  +    N N  +
Sbjct: 312 LTKRRAMQVRNVLNDAVDLLE----FRDRVIKASLNYAHLVVSTSLQCYVFSTKNWN--T 365

Query: 389 EIAWQGSGGNEKYFFENENVCMIFNAGELTLVEYG----NNDTLGSVRTEFMNPHLISVR 444
            I +    G      + E   ++ +   + L  Y     ++     +RT+ +N   +S+ 
Sbjct: 366 PIIFDLKEGTVSLILQAERHFLLVDGSSIYLYSYEGRFISSPKFPGMRTDILNAQTVSLS 425

Query: 445 INERCQRGTEDNKKLAYLIDIKTIAIVDLIGGYNIGT---VSHESRVDWLELNETG---- 497
            N+      + ++K+ +L +  T        G  +G    +SH++ +  + L++ G    
Sbjct: 426 -NDTIAIRDKADEKIIFLFEAST--------GKPLGDGKFLSHKNEILEIALDQKGLTND 476

Query: 498 HKLLFRDRKLRLHLYDIESCSK----TMILNFCSYMQWVPGSDVLVAQNRNSLCVWY--- 550
            K+ F D+   L +  ++   K      +      + W    ++L         VWY   
Sbjct: 477 RKIAFIDKNRDLCITSVKRFGKEEQIIKLGTMVHTLAWNDTCNILCGLQDTRFIVWYYPN 536

Query: 551 -----------------NIEAPERVTMFTIRGDVIGLERGGGKTEVMVMEGVTTVAYTLD 593
                              E  +   + +  G+ + + R  G    +V   +T     L 
Sbjct: 537 TVYVDRDILPKTLYERDASEFSKNPHIVSFVGNQVTIRRADGS---LVHISITPYPAILH 593

Query: 594 EGLIEFGTAIDDGNYIRATAFLETLEMT--PETEAMWKTLSKLALEARQLHIAERCFSAL 651
           E             Y+ ++ + + + +    + + MW  L+ +A+  R +  AE  ++A+
Sbjct: 594 E-------------YVSSSKWEDAVRLCRFVKEQTMWACLAAMAVANRDMTTAEIAYAAI 640

Query: 652 GQVAKARFLHETNEIADQVSREYGGEGTDFYQVRARLAMLEKNYKLAEMIFLEQNAVEEA 711
           G++ K ++++    +  + S+             A + +   N + AE++ L+   V +A
Sbjct: 641 GEIDKVQYINSIKNLPSKESK------------MAHILLFSGNIQEAEIVLLQAGLVYQA 688

Query: 712 MGMYQELHRWDECIAVA 728
           + +   L+ W+  + +A
Sbjct: 689 IQININLYNWERALELA 705


>gi|16554625 WD repeat domain 10 isoform 4 [Homo sapiens]
          Length = 1131

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 56/235 (23%), Positives = 93/235 (39%), Gaps = 22/235 (9%)

Query: 777 GLPAKAARLVLTREELLANTELVEHITAALIKGEL---------------YERAGDLFEK 821
           GL  + A+    R + L   EL+  I     +GE                +  A  L+++
Sbjct: 545 GLDFETAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKR 604

Query: 822 IHNPQKALECYRKGNAFMKAVELARLAFPVEVVKLEEAWGDHLVQQKQLDAAINHYIEAR 881
             +   ALE Y     F  A +      P E   L     D     K+  AA+  YI A 
Sbjct: 605 SGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAG 664

Query: 882 CSIKAIEAALGARQWKKAIYILDLQDRNTASKYYPLV--AQHYASLQEYEIAEELYTKGD 939
             +KAIE   G   W     ++D+  +   ++  PL+  A +   L     A E Y K  
Sbjct: 665 EHVKAIEIC-GDHGW--VDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMG 721

Query: 940 RTKDAIDMYTQAGRWEQAHKLAMKCMRPEDVSVLYITQAQEMEKQGKYREAERLY 994
             K  + ++ +  RW++A  L  K   PE    +Y+  AQ + +  ++ EA++ +
Sbjct: 722 DLKSLVQLHVETQRWDEAFALGEK--HPEFKDDIYMPYAQWLAENDRFEEAQKAF 774



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 52/208 (25%), Positives = 91/208 (43%), Gaps = 31/208 (14%)

Query: 984  QGKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLVGKHHPDLLSDTHLHLGKELEAEG 1043
            QGK+ EA +LY      +LA+ MY    +++     +G   P    +T + + K+ +   
Sbjct: 592  QGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDP---KETKMLITKQADWAR 648

Query: 1044 RLQEAEYHYLEAQEWKATVNMYRASGLWEEAYRVARTQGGANAHKHVA------------ 1091
             ++E           KA V MY ++G   +A  +    G  +    +A            
Sbjct: 649  NIKEP----------KAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLL 698

Query: 1092 ----YLWAKSLGGEAAVRLLNKLGLLEAAVDHAADNCSFEFAFELSRLALKHKTPEVHLK 1147
                YL      G AA   L K+G L++ V    +   ++ AF L     + K  ++++ 
Sbjct: 699  LCATYLKKLDSPGYAAETYL-KMGDLKSLVQLHVETQRWDEAFALGEKHPEFKD-DIYMP 756

Query: 1148 YAMFLEDEGKFEEAEAEFIRAGKPKEAV 1175
            YA +L +  +FEEA+  F +AG+ +EAV
Sbjct: 757  YAQWLAENDRFEEAQKAFHKAGRQREAV 784



 Score = 34.7 bits (78), Expect = 0.84
 Identities = 54/252 (21%), Positives = 102/252 (40%), Gaps = 33/252 (13%)

Query: 1158 FEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVGQARGALEEKDFQ 1217
            FE A+  FIR    +   L+       E  ++  E ++   +A+V   Q +       F 
Sbjct: 548  FETAKKAFIRVQDLRYLELI----SSIEERKKRGETNNDLFLADVFSYQGK-------FH 596

Query: 1218 KAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPSQLEALQEEYEREATKKG--ARG 1275
            +A  L  R+    LAL  Y +  ++  A    KD++ S      +E +   TK+   AR 
Sbjct: 597  EAAKLYKRSGHENLALEMYTDLCMFEYA----KDFLGS---GDPKETKMLITKQADWARN 649

Query: 1276 VEGFVEQARHWEQAGEYSRAVDCYLKVRDSGNSGLAEKCWMKAAELSIKFLPPQRNMEVV 1335
            ++        +  AGE+ +A++        G+ G  +     A +L       +   E +
Sbjct: 650  IKEPKAAVEMYISAGEHVKAIEI------CGDHGWVDMLIDIARKLD------KAEREPL 697

Query: 1336 LAVGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRVAKELDPRYEDYVDQH 1395
            L     L  +     AAE YL +  +K  +   +E + W++A  +  E  P ++D +   
Sbjct: 698  LLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALG-EKHPEFKDDIYMP 756

Query: 1396 YKEFLKNQGKVD 1407
            Y ++L    + +
Sbjct: 757  YAQWLAENDRFE 768



 Score = 31.6 bits (70), Expect = 7.1
 Identities = 29/107 (27%), Positives = 44/107 (41%), Gaps = 17/107 (15%)

Query: 1150 MFLED----EGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVG 1205
            +FL D    +GKF EA   + R+G    A+ M+     +E A+    + DP     ++  
Sbjct: 583  LFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITK 642

Query: 1206 QARGALEEKDFQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDY 1252
            QA  A   K+             P  A+  Y  AG    A+ IC D+
Sbjct: 643  QADWARNIKE-------------PKAAVEMYISAGEHVKAIEICGDH 676



 Score = 31.6 bits (70), Expect = 7.1
 Identities = 18/72 (25%), Positives = 33/72 (45%), Gaps = 3/72 (4%)

Query: 702 FLEQNAVEEAMGMYQELHRWDECIAVAEAKGHPAL-EKLRRSYYQWLMDTQQEERAGELQ 760
           +L+   ++  + ++ E  RWDE  A+ E   HP   + +   Y QWL +  + E A +  
Sbjct: 717 YLKMGDLKSLVQLHVETQRWDEAFALGEK--HPEFKDDIYMPYAQWLAENDRFEEAQKAF 774

Query: 761 ESQGDGLAAISL 772
              G    A+ +
Sbjct: 775 HKAGRQREAVQV 786


>gi|16554619 WD repeat domain 10 isoform 3 [Homo sapiens]
          Length = 1182

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 56/235 (23%), Positives = 93/235 (39%), Gaps = 22/235 (9%)

Query: 777 GLPAKAARLVLTREELLANTELVEHITAALIKGEL---------------YERAGDLFEK 821
           GL  + A+    R + L   EL+  I     +GE                +  A  L+++
Sbjct: 597 GLDFETAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKR 656

Query: 822 IHNPQKALECYRKGNAFMKAVELARLAFPVEVVKLEEAWGDHLVQQKQLDAAINHYIEAR 881
             +   ALE Y     F  A +      P E   L     D     K+  AA+  YI A 
Sbjct: 657 SGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAG 716

Query: 882 CSIKAIEAALGARQWKKAIYILDLQDRNTASKYYPLV--AQHYASLQEYEIAEELYTKGD 939
             +KAIE   G   W     ++D+  +   ++  PL+  A +   L     A E Y K  
Sbjct: 717 EHVKAIEIC-GDHGW--VDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMG 773

Query: 940 RTKDAIDMYTQAGRWEQAHKLAMKCMRPEDVSVLYITQAQEMEKQGKYREAERLY 994
             K  + ++ +  RW++A  L  K   PE    +Y+  AQ + +  ++ EA++ +
Sbjct: 774 DLKSLVQLHVETQRWDEAFALGEK--HPEFKDDIYMPYAQWLAENDRFEEAQKAF 826



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 52/208 (25%), Positives = 91/208 (43%), Gaps = 31/208 (14%)

Query: 984  QGKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLVGKHHPDLLSDTHLHLGKELEAEG 1043
            QGK+ EA +LY      +LA+ MY    +++     +G   P    +T + + K+ +   
Sbjct: 644  QGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDP---KETKMLITKQADWAR 700

Query: 1044 RLQEAEYHYLEAQEWKATVNMYRASGLWEEAYRVARTQGGANAHKHVA------------ 1091
             ++E           KA V MY ++G   +A  +    G  +    +A            
Sbjct: 701  NIKEP----------KAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLL 750

Query: 1092 ----YLWAKSLGGEAAVRLLNKLGLLEAAVDHAADNCSFEFAFELSRLALKHKTPEVHLK 1147
                YL      G AA   L K+G L++ V    +   ++ AF L     + K  ++++ 
Sbjct: 751  LCATYLKKLDSPGYAAETYL-KMGDLKSLVQLHVETQRWDEAFALGEKHPEFKD-DIYMP 808

Query: 1148 YAMFLEDEGKFEEAEAEFIRAGKPKEAV 1175
            YA +L +  +FEEA+  F +AG+ +EAV
Sbjct: 809  YAQWLAENDRFEEAQKAFHKAGRQREAV 836



 Score = 35.0 bits (79), Expect = 0.64
 Identities = 55/264 (20%), Positives = 110/264 (41%), Gaps = 34/264 (12%)

Query: 8   TLLSPQDGAAK-VTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGRKS 66
           TLL P  G    V C+A++++  +FA  + D+ V+++    E   K++   A        
Sbjct: 44  TLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDA-------- 95

Query: 67  YMVKGMAFSPDSTKIAIGQTDNIIYVYKIGEDWGDKKVICNKFIQTSAVTCLQWPAE-YI 125
             ++ ++++P + ++A   + +          W  ++   +K   +S + C  W  +   
Sbjct: 96  --IQCVSYNPITHQLASCSSSDFGL-------WSPEQKSVSKHKSSSKIICCSWTNDGQY 146

Query: 126 IVFGLAEGKVRLANTKTNKSSTIY---GTESYVVSLTTNCSGK---GILSGHADGTIVRY 179
           +  G+  G + + N    +   I    G+ S + S+  N S +    IL+    G  V +
Sbjct: 147 LALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSREERNDILAVADWGQKVSF 206

Query: 180 FFDDEGSGESQGKLVNHPCPPYALAWATNS--IVAAGCDRKIVAYGKEGHMLQTFDYSRD 237
           +   + SG+  GK       P  +++ T    I+  G D+++  + K+G  L T      
Sbjct: 207 Y---QLSGKQIGKDRALNFDPCCISYFTKGEYILLGGSDKQVSLFTKDGVRLGTV----G 259

Query: 238 PQEREFTTAVSSPGGQSVVLGSYD 261
            Q     T  + P    VV+G  D
Sbjct: 260 EQNSWVWTCQAKPDSNYVVVGCQD 283



 Score = 34.7 bits (78), Expect = 0.84
 Identities = 54/252 (21%), Positives = 102/252 (40%), Gaps = 33/252 (13%)

Query: 1158 FEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVGQARGALEEKDFQ 1217
            FE A+  FIR    +   L+       E  ++  E ++   +A+V   Q +       F 
Sbjct: 600  FETAKKAFIRVQDLRYLELI----SSIEERKKRGETNNDLFLADVFSYQGK-------FH 648

Query: 1218 KAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPSQLEALQEEYEREATKKG--ARG 1275
            +A  L  R+    LAL  Y +  ++  A    KD++ S      +E +   TK+   AR 
Sbjct: 649  EAAKLYKRSGHENLALEMYTDLCMFEYA----KDFLGS---GDPKETKMLITKQADWARN 701

Query: 1276 VEGFVEQARHWEQAGEYSRAVDCYLKVRDSGNSGLAEKCWMKAAELSIKFLPPQRNMEVV 1335
            ++        +  AGE+ +A++        G+ G  +     A +L       +   E +
Sbjct: 702  IKEPKAAVEMYISAGEHVKAIEI------CGDHGWVDMLIDIARKLD------KAEREPL 749

Query: 1336 LAVGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRVAKELDPRYEDYVDQH 1395
            L     L  +     AAE YL +  +K  +   +E + W++A  +  E  P ++D +   
Sbjct: 750  LLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALG-EKHPEFKDDIYMP 808

Query: 1396 YKEFLKNQGKVD 1407
            Y ++L    + +
Sbjct: 809  YAQWLAENDRFE 820



 Score = 31.6 bits (70), Expect = 7.1
 Identities = 29/107 (27%), Positives = 44/107 (41%), Gaps = 17/107 (15%)

Query: 1150 MFLED----EGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVG 1205
            +FL D    +GKF EA   + R+G    A+ M+     +E A+    + DP     ++  
Sbjct: 635  LFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITK 694

Query: 1206 QARGALEEKDFQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDY 1252
            QA  A   K+             P  A+  Y  AG    A+ IC D+
Sbjct: 695  QADWARNIKE-------------PKAAVEMYISAGEHVKAIEICGDH 728



 Score = 31.6 bits (70), Expect = 7.1
 Identities = 18/72 (25%), Positives = 33/72 (45%), Gaps = 3/72 (4%)

Query: 702 FLEQNAVEEAMGMYQELHRWDECIAVAEAKGHPAL-EKLRRSYYQWLMDTQQEERAGELQ 760
           +L+   ++  + ++ E  RWDE  A+ E   HP   + +   Y QWL +  + E A +  
Sbjct: 769 YLKMGDLKSLVQLHVETQRWDEAFALGEK--HPEFKDDIYMPYAQWLAENDRFEEAQKAF 826

Query: 761 ESQGDGLAAISL 772
              G    A+ +
Sbjct: 827 HKAGRQREAVQV 838


>gi|16554623 WD repeat domain 10 isoform 2 [Homo sapiens]
          Length = 1241

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 56/235 (23%), Positives = 93/235 (39%), Gaps = 22/235 (9%)

Query: 777 GLPAKAARLVLTREELLANTELVEHITAALIKGEL---------------YERAGDLFEK 821
           GL  + A+    R + L   EL+  I     +GE                +  A  L+++
Sbjct: 656 GLDFETAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKR 715

Query: 822 IHNPQKALECYRKGNAFMKAVELARLAFPVEVVKLEEAWGDHLVQQKQLDAAINHYIEAR 881
             +   ALE Y     F  A +      P E   L     D     K+  AA+  YI A 
Sbjct: 716 SGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAG 775

Query: 882 CSIKAIEAALGARQWKKAIYILDLQDRNTASKYYPLV--AQHYASLQEYEIAEELYTKGD 939
             +KAIE   G   W     ++D+  +   ++  PL+  A +   L     A E Y K  
Sbjct: 776 EHVKAIEIC-GDHGW--VDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMG 832

Query: 940 RTKDAIDMYTQAGRWEQAHKLAMKCMRPEDVSVLYITQAQEMEKQGKYREAERLY 994
             K  + ++ +  RW++A  L  K   PE    +Y+  AQ + +  ++ EA++ +
Sbjct: 833 DLKSLVQLHVETQRWDEAFALGEK--HPEFKDDIYMPYAQWLAENDRFEEAQKAF 885



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 52/208 (25%), Positives = 91/208 (43%), Gaps = 31/208 (14%)

Query: 984  QGKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLVGKHHPDLLSDTHLHLGKELEAEG 1043
            QGK+ EA +LY      +LA+ MY    +++     +G   P    +T + + K+ +   
Sbjct: 703  QGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDP---KETKMLITKQADWAR 759

Query: 1044 RLQEAEYHYLEAQEWKATVNMYRASGLWEEAYRVARTQGGANAHKHVA------------ 1091
             ++E           KA V MY ++G   +A  +    G  +    +A            
Sbjct: 760  NIKEP----------KAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLL 809

Query: 1092 ----YLWAKSLGGEAAVRLLNKLGLLEAAVDHAADNCSFEFAFELSRLALKHKTPEVHLK 1147
                YL      G AA   L K+G L++ V    +   ++ AF L     + K  ++++ 
Sbjct: 810  LCATYLKKLDSPGYAAETYL-KMGDLKSLVQLHVETQRWDEAFALGEKHPEFKD-DIYMP 867

Query: 1148 YAMFLEDEGKFEEAEAEFIRAGKPKEAV 1175
            YA +L +  +FEEA+  F +AG+ +EAV
Sbjct: 868  YAQWLAENDRFEEAQKAFHKAGRQREAV 895



 Score = 34.7 bits (78), Expect = 0.84
 Identities = 54/252 (21%), Positives = 102/252 (40%), Gaps = 33/252 (13%)

Query: 1158 FEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVGQARGALEEKDFQ 1217
            FE A+  FIR    +   L+       E  ++  E ++   +A+V   Q +       F 
Sbjct: 659  FETAKKAFIRVQDLRYLELI----SSIEERKKRGETNNDLFLADVFSYQGK-------FH 707

Query: 1218 KAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPSQLEALQEEYEREATKKG--ARG 1275
            +A  L  R+    LAL  Y +  ++  A    KD++ S      +E +   TK+   AR 
Sbjct: 708  EAAKLYKRSGHENLALEMYTDLCMFEYA----KDFLGS---GDPKETKMLITKQADWARN 760

Query: 1276 VEGFVEQARHWEQAGEYSRAVDCYLKVRDSGNSGLAEKCWMKAAELSIKFLPPQRNMEVV 1335
            ++        +  AGE+ +A++        G+ G  +     A +L       +   E +
Sbjct: 761  IKEPKAAVEMYISAGEHVKAIEI------CGDHGWVDMLIDIARKLD------KAEREPL 808

Query: 1336 LAVGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRVAKELDPRYEDYVDQH 1395
            L     L  +     AAE YL +  +K  +   +E + W++A  +  E  P ++D +   
Sbjct: 809  LLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALG-EKHPEFKDDIYMP 867

Query: 1396 YKEFLKNQGKVD 1407
            Y ++L    + +
Sbjct: 868  YAQWLAENDRFE 879



 Score = 31.6 bits (70), Expect = 7.1
 Identities = 29/107 (27%), Positives = 44/107 (41%), Gaps = 17/107 (15%)

Query: 1150 MFLED----EGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVG 1205
            +FL D    +GKF EA   + R+G    A+ M+     +E A+    + DP     ++  
Sbjct: 694  LFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITK 753

Query: 1206 QARGALEEKDFQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDY 1252
            QA  A   K+             P  A+  Y  AG    A+ IC D+
Sbjct: 754  QADWARNIKE-------------PKAAVEMYISAGEHVKAIEICGDH 787



 Score = 31.6 bits (70), Expect = 7.1
 Identities = 18/72 (25%), Positives = 33/72 (45%), Gaps = 3/72 (4%)

Query: 702 FLEQNAVEEAMGMYQELHRWDECIAVAEAKGHPAL-EKLRRSYYQWLMDTQQEERAGELQ 760
           +L+   ++  + ++ E  RWDE  A+ E   HP   + +   Y QWL +  + E A +  
Sbjct: 828 YLKMGDLKSLVQLHVETQRWDEAFALGEK--HPEFKDDIYMPYAQWLAENDRFEEAQKAF 885

Query: 761 ESQGDGLAAISL 772
              G    A+ +
Sbjct: 886 HKAGRQREAVQV 897


>gi|16554621 WD repeat domain 10 isoform 1 [Homo sapiens]
          Length = 1292

 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 56/235 (23%), Positives = 93/235 (39%), Gaps = 22/235 (9%)

Query: 777 GLPAKAARLVLTREELLANTELVEHITAALIKGEL---------------YERAGDLFEK 821
           GL  + A+    R + L   EL+  I     +GE                +  A  L+++
Sbjct: 707 GLDFETAKKAFIRVQDLRYLELISSIEERKKQGETNNDLFLADVFSYQGKFHEAAKLYKR 766

Query: 822 IHNPQKALECYRKGNAFMKAVELARLAFPVEVVKLEEAWGDHLVQQKQLDAAINHYIEAR 881
             +   ALE Y     F  A +      P E   L     D     K+  AA+  YI A 
Sbjct: 767 SGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAG 826

Query: 882 CSIKAIEAALGARQWKKAIYILDLQDRNTASKYYPLV--AQHYASLQEYEIAEELYTKGD 939
             +KAIE   G   W     ++D+  +   ++  PL+  A +   L     A E Y K  
Sbjct: 827 EHVKAIEIC-GDHGW--VDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMG 883

Query: 940 RTKDAIDMYTQAGRWEQAHKLAMKCMRPEDVSVLYITQAQEMEKQGKYREAERLY 994
             K  + ++ +  RW++A  L  K   PE    +Y+  AQ + +  ++ EA++ +
Sbjct: 884 DLKSLVQLHVETQRWDEAFALGEK--HPEFKDDIYMPYAQWLAENDRFEEAQKAF 936



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 52/208 (25%), Positives = 91/208 (43%), Gaps = 31/208 (14%)

Query: 984  QGKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLVGKHHPDLLSDTHLHLGKELEAEG 1043
            QGK+ EA +LY      +LA+ MY    +++     +G   P    +T + + K+ +   
Sbjct: 754  QGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDP---KETKMLITKQADWAR 810

Query: 1044 RLQEAEYHYLEAQEWKATVNMYRASGLWEEAYRVARTQGGANAHKHVA------------ 1091
             ++E           KA V MY ++G   +A  +    G  +    +A            
Sbjct: 811  NIKEP----------KAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLL 860

Query: 1092 ----YLWAKSLGGEAAVRLLNKLGLLEAAVDHAADNCSFEFAFELSRLALKHKTPEVHLK 1147
                YL      G AA   L K+G L++ V    +   ++ AF L     + K  ++++ 
Sbjct: 861  LCATYLKKLDSPGYAAETYL-KMGDLKSLVQLHVETQRWDEAFALGEKHPEFKD-DIYMP 918

Query: 1148 YAMFLEDEGKFEEAEAEFIRAGKPKEAV 1175
            YA +L +  +FEEA+  F +AG+ +EAV
Sbjct: 919  YAQWLAENDRFEEAQKAFHKAGRQREAV 946



 Score = 35.0 bits (79), Expect = 0.64
 Identities = 54/252 (21%), Positives = 102/252 (40%), Gaps = 33/252 (13%)

Query: 1158 FEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVGQARGALEEKDFQ 1217
            FE A+  FIR    +   L+       E  ++  E ++   +A+V   Q +       F 
Sbjct: 710  FETAKKAFIRVQDLRYLELI----SSIEERKKQGETNNDLFLADVFSYQGK-------FH 758

Query: 1218 KAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPSQLEALQEEYEREATKKG--ARG 1275
            +A  L  R+    LAL  Y +  ++  A    KD++ S      +E +   TK+   AR 
Sbjct: 759  EAAKLYKRSGHENLALEMYTDLCMFEYA----KDFLGS---GDPKETKMLITKQADWARN 811

Query: 1276 VEGFVEQARHWEQAGEYSRAVDCYLKVRDSGNSGLAEKCWMKAAELSIKFLPPQRNMEVV 1335
            ++        +  AGE+ +A++        G+ G  +     A +L       +   E +
Sbjct: 812  IKEPKAAVEMYISAGEHVKAIEI------CGDHGWVDMLIDIARKLD------KAEREPL 859

Query: 1336 LAVGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRVAKELDPRYEDYVDQH 1395
            L     L  +     AAE YL +  +K  +   +E + W++A  +  E  P ++D +   
Sbjct: 860  LLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALG-EKHPEFKDDIYMP 918

Query: 1396 YKEFLKNQGKVD 1407
            Y ++L    + +
Sbjct: 919  YAQWLAENDRFE 930



 Score = 31.6 bits (70), Expect = 7.1
 Identities = 29/107 (27%), Positives = 44/107 (41%), Gaps = 17/107 (15%)

Query: 1150 MFLED----EGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVG 1205
            +FL D    +GKF EA   + R+G    A+ M+     +E A+    + DP     ++  
Sbjct: 745  LFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITK 804

Query: 1206 QARGALEEKDFQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDY 1252
            QA  A   K+             P  A+  Y  AG    A+ IC D+
Sbjct: 805  QADWARNIKE-------------PKAAVEMYISAGEHVKAIEICGDH 838



 Score = 31.6 bits (70), Expect = 7.1
 Identities = 18/72 (25%), Positives = 33/72 (45%), Gaps = 3/72 (4%)

Query: 702 FLEQNAVEEAMGMYQELHRWDECIAVAEAKGHPAL-EKLRRSYYQWLMDTQQEERAGELQ 760
           +L+   ++  + ++ E  RWDE  A+ E   HP   + +   Y QWL +  + E A +  
Sbjct: 879 YLKMGDLKSLVQLHVETQRWDEAFALGEK--HPEFKDDIYMPYAQWLAENDRFEEAQKAF 936

Query: 761 ESQGDGLAAISL 772
              G    A+ +
Sbjct: 937 HKAGRQREAVQV 948


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 64/264 (24%), Positives = 114/264 (43%), Gaps = 39/264 (14%)

Query: 19  VTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGRKSYMVKGMAFSPDS 78
           V+ + +S N    A  + DR+++++  +  + +K         YG  +  +  +A+S DS
Sbjct: 44  VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEK-------TLYGH-NLEISDVAWSSDS 95

Query: 79  TKIAIGQTDNIIYVYKIGEDWGDKKVICNKFIQ--TSAVTCLQW-PAEYIIVFGLAEGKV 135
           +++     D  + +      W  +   C K ++  ++ V C  + P   +I+ G  +  V
Sbjct: 96  SRLVSASDDKTLKL------WDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETV 149

Query: 136 RLANTKTNKS-STIYGTESYVVSLTTNCSGKGILSGHADGTIVRYFFDDEGSGESQGKLV 194
           ++   KT K   T+      V ++  NCSG  I+SG  DG + R +  D  SG+    LV
Sbjct: 150 KIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDG-LCRIW--DAASGQCLKTLV 206

Query: 195 NHPCPPYALAWATNSIVAAGCDRKIVAYGKEGHMLQTFDYSRDPQEREFT---------- 244
           +   PP        S V    + K +      + L+ +DYSR    + +T          
Sbjct: 207 DDDNPPV-------SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIF 259

Query: 245 TAVSSPGGQSVVLGSYDRLRVFNW 268
              S  GG+ +V GS D L V+ W
Sbjct: 260 ANFSVTGGKWIVSGSEDNL-VYIW 282


>gi|41281447 intraflagellar transport 140 [Homo sapiens]
          Length = 1462

 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 85/391 (21%), Positives = 148/391 (37%), Gaps = 97/391 (24%)

Query: 623  ETEAMWKTLSKLALEARQLHIAERCFSALGQVAKARFLHETNEIADQVSREYGGEGTDFY 682
            ++EA+W+ ++++ ++ ++L +A+ C   +G    AR L E  +  +  +R          
Sbjct: 799  KSEAVWENMARMCVKTQRLDVAKVCLGNMGHARGARALREAEQEPELEAR--------VA 850

Query: 683  QVRARLAMLEKNYKLAEMIFLEQNAVEEAMGMYQELHRWDECIAVAEAKGHPALEKLRRS 742
             +  +L MLE     AE ++ +    +     YQ   RW E + VAE   H     LR +
Sbjct: 851  VLATQLGMLED----AEQLYRKCKRHDLLNKFYQAAGRWQEALQVAE---HHDRVHLRST 903

Query: 743  YYQWLMDTQQEERAGELQESQGDGLAAISLYLKAGLPAKAARLVLTRE----ELLAN--- 795
            Y+++         AG L E+  D   A+S Y K+         +L+ +    EL  N   
Sbjct: 904  YHRY---------AGHL-EASADCSRALSYYEKSDTHRFEVPRMLSEDLPSLELYVNKMK 953

Query: 796  -----------TELVEHITAALIKGELYERAGDLFE--KIH----NPQKALEC------- 831
                        E    + AAL     YE A D F   +IH    N QKA +        
Sbjct: 954  DKTLWRWWAQYLESQGEMDAAL---HYYELARDHFSLVRIHCFQGNVQKAAQIANETGNL 1010

Query: 832  ----------------------YRKGNAFMKAV-------------ELARLAFPVEVVKL 856
                                  Y +  AF  A+              LA L+ P ++++ 
Sbjct: 1011 AASYHLARQYESQEEVGQAVHFYTRAQAFKNAIRLCKENGLDDQLMNLALLSSPEDMIEA 1070

Query: 857  EEAWGDHLVQQKQLDAAINHYIEARCSIKAIEAALGARQWKKAIYILDLQDRNTASKYYP 916
               + +  V   Q+D A+  Y +A    KA+E A   +Q+     I +  D  +      
Sbjct: 1071 ARYYEEKGV---QMDRAVMLYHKAGHFSKALELAFATQQFVALQLIAEDLDETSDPALLA 1127

Query: 917  LVAQHYASLQEYEIAEELYTKGDRTKDAIDM 947
              +  +    +YE A EL     + ++A+ +
Sbjct: 1128 RCSDFFIEHSQYERAVELLLAARKYQEALQL 1158



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 66/355 (18%), Positives = 136/355 (38%), Gaps = 13/355 (3%)

Query: 893  ARQWKKAIYILDLQDRNTASKYYPLVAQHYASLQEYEIAEELYTKGDRTKDAIDMYTQAG 952
            A +W++A+ + +  DR      Y   A H  +  +   A   Y K D  +  +       
Sbjct: 882  AGRWQEALQVAEHHDRVHLRSTYHRYAGHLEASADCSRALSYYEKSDTHRFEVPRMLS-- 939

Query: 953  RWEQAHKLAMKCMRPEDVSVLYITQAQEMEKQGKYREAERLYVTVQEPDLAITMYKKHKL 1012
              E    L +   + +D   L+   AQ +E QG+   A   Y   ++     ++ + H  
Sbjct: 940  --EDLPSLELYVNKMKD-KTLWRWWAQYLESQGEMDAALHYYELARDH---FSLVRIHCF 993

Query: 1013 YDDMIRLVGKHHPDLLSDTHLHLGKELEAEGRLQEAEYHYLEAQEWKATVNMYRASGLWE 1072
              ++ +     +         HL ++ E++  + +A + Y  AQ +K  + + + +GL +
Sbjct: 994  QGNVQKAAQIANETGNLAASYHLARQYESQEEVGQAVHFYTRAQAFKNAIRLCKENGLDD 1053

Query: 1073 EAYRVARTQGGANAHKHVAYLWAKSLGGEAAVRLLNKLGLLEAAVDHAADNCSFEFAFEL 1132
            +   +A      +  +   Y   K +  + AV L +K G    A++ A     F     +
Sbjct: 1054 QLMNLALLSSPEDMIEAARYYEEKGVQMDRAVMLYHKAGHFSKALELAFATQQFVALQLI 1113

Query: 1133 SRLALKHKTPEVHLKYAMFLEDEGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAE 1192
            +    +   P +  + + F  +  ++E A  E + A +  +  L     Q+    + +AE
Sbjct: 1114 AEDLDETSDPALLARCSDFFIEHSQYERA-VELLLAARKYQEALQLCLGQNMSITEEMAE 1172

Query: 1193 AHDPDSVAEVLVGQARGALEEKDFQKAEGLLLRAQRPGLALNYYKEAGLWSDALR 1247
                   +  L  ++R  L     ++     +R     LA   Y +AG    A+R
Sbjct: 1173 KMTVAKDSSDLPEESRREL----LEQIADCCMRQGSYHLATKKYTQAGNKLKAMR 1223



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 78/382 (20%), Positives = 150/382 (39%), Gaps = 68/382 (17%)

Query: 985  GKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLVGKHHPDL----------------- 1027
            G   +AE+LY   +  DL    Y+    + + ++ V +HH  +                 
Sbjct: 857  GMLEDAEQLYRKCKRHDLLNKFYQAAGRWQEALQ-VAEHHDRVHLRSTYHRYAGHLEASA 915

Query: 1028 ----------LSDTH----------------LHLGK------------ELEAEGRLQEAE 1049
                       SDTH                L++ K             LE++G +  A 
Sbjct: 916  DCSRALSYYEKSDTHRFEVPRMLSEDLPSLELYVNKMKDKTLWRWWAQYLESQGEMDAAL 975

Query: 1050 YHYLEAQEWKATVNMYRASGLWEEAYRVARTQGGANAHKHVAYLWAKSLGGEAAVRLLNK 1109
            ++Y  A++  + V ++   G  ++A ++A   G   A  H+A  +        AV    +
Sbjct: 976  HYYELARDHFSLVRIHCFQGNVQKAAQIANETGNLAASYHLARQYESQEEVGQAVHFYTR 1035

Query: 1110 LGLLEAAVDHAADNCSFEFAFELSRLALKHKTPEVHLKYAMFLEDEG-KFEEAEAEFIRA 1168
                + A+    +N   +   +L  LAL   +PE  ++ A + E++G + + A   + +A
Sbjct: 1036 AQAFKNAIRLCKENGLDD---QLMNLALL-SSPEDMIEAARYYEEKGVQMDRAVMLYHKA 1091

Query: 1169 GKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVGQARGALEEKDFQKAEGLLLRAQR 1228
            G   +A+ +    Q + A Q +AE  D  S   +L   +   +E   +++A  LLL A++
Sbjct: 1092 GHFSKALELAFATQQFVALQLIAEDLDETSDPALLARCSDFFIEHSQYERAVELLLAARK 1151

Query: 1229 PGLALNYYKEAGL-----WSDALRICKDYVPSQLEALQEEYEREATKKGARGVEGFVEQA 1283
               AL       +      ++ + + KD      E+ +E  E+ A     +G   +    
Sbjct: 1152 YQEALQLCLGQNMSITEEMAEKMTVAKDSSDLPEESRRELLEQIADCCMRQG--SYHLAT 1209

Query: 1284 RHWEQAGEYSRAVDCYLKVRDS 1305
            + + QAG   +A+   LK  D+
Sbjct: 1210 KKYTQAGNKLKAMRALLKSGDT 1231


>gi|55743151 WD repeat domain 19 [Homo sapiens]
          Length = 1342

 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 87/386 (22%), Positives = 150/386 (38%), Gaps = 43/386 (11%)

Query: 877  YIEARCSIKAIEAALGARQWKKAIYILDLQDRNTASKYYPLVAQHYASLQE----YEIAE 932
            Y+ + C I A+E     + W  A+ +     ++ A    P +++ YA   E    Y  A 
Sbjct: 740  YLASSCPIAALEMRRDLQHWDSALQLA----KHLAPDQIPFISKEYAIQLEFAGDYVNAL 795

Query: 933  ELYTKG----DRTKD------AIDMYTQAGRWEQAHKLAMKCMRPEDVSVLYITQAQEME 982
              Y KG    ++  D         M  + G   +    A+K        VL       +E
Sbjct: 796  AHYEKGITGDNKEHDEACLAGVAQMSIRMGDIRRGVNQALK----HPSRVLKRDCGAILE 851

Query: 983  KQGKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLVGKHHPDLLSDT-HLHLGKELEA 1041
               ++ EA +LY      D A ++Y + K +      VG   P + S   HL   K  EA
Sbjct: 852  NMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAK----VGDLLPHVSSPKIHLQYAKAKEA 907

Query: 1042 EGRLQEAEYHYLEAQEWKATVNMYRAS-GLWEEAYRVARTQGGANAHKHVAYLWAKSLGG 1100
            +GR +EA   Y  A++W++ + +Y       E+A  + R     +  K VA  + +    
Sbjct: 908  DGRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNIVRETQSLDGAKMVARFFLQLGDY 967

Query: 1101 EAAVRLLNKLGLLEAAVDHAADNCSFEFAFELSRLALKHKTPEVHLKYAMFLEDEGKFEE 1160
             +A++ L        A   A  +   E   ++  +  +  T E +   A++ E E ++ +
Sbjct: 968  GSAIQFLVMSKCNNEAFTLAQQHNKMEIYADI--IGSEDTTNEDYQSIALYFEGEKRYLQ 1025

Query: 1161 AEAEFIRAGKPKEAVLMFVHNQDWE-------AAQRVAEAHDPDSVAEVLVGQARGALEE 1213
            A   F+  G+   A+  F+     E       A + V +A D + +   L+    G  E 
Sbjct: 1026 AGKFFLLCGQYSRALKHFLKCPSSEDNVAIEMAIETVGQAKD-ELLTNQLIDHLLG--EN 1082

Query: 1214 KDFQKAEGLLLRAQRPGLALNYYKEA 1239
                K    L R     +AL  Y+EA
Sbjct: 1083 DGMPKDAKYLFRLY---MALKQYREA 1105



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 50/207 (24%), Positives = 77/207 (37%), Gaps = 42/207 (20%)

Query: 1210 ALEEKDFQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPSQLEALQEEYEREAT 1269
            A+   D+  A+ L L +  P  AL   ++   W  AL++ K   P Q+  + +EY     
Sbjct: 727  AMFTNDYNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHLAPDQIPFISKEY----- 781

Query: 1270 KKGARGVEGFVEQARHWEQAGEYSRAVDCYLKVRDSGNSGLAEKCWMKAAELSIKFLPPQ 1329
                         A   E AG+Y  A+  Y K     N    E C    A++SI+    +
Sbjct: 782  -------------AIQLEFAGDYVNALAHYEKGITGDNKEHDEACLAGVAQMSIRMGDIR 828

Query: 1330 RNMEVVLA---------VGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRV 1380
            R +   L           G  L  + + S AA+LY       +A   +I  + W K   +
Sbjct: 829  RGVNQALKHPSRVLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDL 888

Query: 1381 ---------------AKELDPRYEDYV 1392
                           AKE D RY++ V
Sbjct: 889  LPHVSSPKIHLQYAKAKEADGRYKEAV 915



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 82/440 (18%), Positives = 156/440 (35%), Gaps = 94/440 (21%)

Query: 625  EAMWKTLSKLALEARQLHIAERCFSALGQVAKARFLHETNEIADQVSREYGGEGTDFYQV 684
            EA W  L++  L   ++  A R +  +G V     L +   I D            +  +
Sbjct: 675  EAAWNELARACLHHMEVEFAIRVYRRIGNVGIVMSLEQIKGIED------------YNLL 722

Query: 685  RARLAMLEKNYKLAEMIFLEQNAVEEAMGMYQELHRWDECIAVAEAKGHPALEKLRRSYY 744
               LAM   +Y LA+ ++L  +    A+ M ++L  WD  + +A+      +  + + Y 
Sbjct: 723  AGHLAMFTNDYNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHLAPDQIPFISKEYA 782

Query: 745  QWLMDTQQEERAGELQESQGDGLAAISLYLKAGLPAKAARLVLTREELLANTELVEHITA 804
              L             E  GD + A++ Y K                     +  EH  A
Sbjct: 783  IQL-------------EFAGDYVNALAHYEKG-----------------ITGDNKEHDEA 812

Query: 805  ALI-KGELYERAGDLFEKIHNPQKALECYRKGNAFMKAVELARLAFPVEVVKLEEAWGDH 863
             L    ++  R GD+   ++                       L  P  V+K +   G  
Sbjct: 813  CLAGVAQMSIRMGDIRRGVNQ---------------------ALKHPSRVLKRD--CGAI 849

Query: 864  LVQQKQLDAAINHYIEARCSIKAIEAALGARQWKKAIYILDLQDRNTASKYYPLVAQHYA 923
            L   KQ   A   Y +     KA    + ++ W K   + DL    ++    P +   YA
Sbjct: 850  LENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAK---VGDLLPHVSS----PKIHLQYA 902

Query: 924  SLQEYEIAEELYTKGDRTKDAIDMYTQAGRWEQAHKLAMKCMRPEDVSVLYITQAQEME- 982
              +E +          R K+A+  Y  A +W+   ++ +  +   + +V  + + Q ++ 
Sbjct: 903  KAKEAD---------GRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNIVRETQSLDG 953

Query: 983  ---------KQGKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLVGKHHPDLLSDTHL 1033
                     + G Y  A +  V  +  + A T+ ++H   +    ++G    D  ++ + 
Sbjct: 954  AKMVARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYADIIGSE--DTTNEDYQ 1011

Query: 1034 HLGKELEAEGRLQEAEYHYL 1053
             +    E E R  +A   +L
Sbjct: 1012 SIALYFEGEKRYLQAGKFFL 1031



 Score = 41.2 bits (95), Expect = 0.009
 Identities = 70/332 (21%), Positives = 136/332 (40%), Gaps = 28/332 (8%)

Query: 987  YREAERLYVTVQEPDLAITMYKKHKLYDDMIRLVGKHHPDLLSDTHLHLGKELEAEGRLQ 1046
            Y  A+ LY+    P  A+ M +  + +D  ++L     PD +         +LE  G   
Sbjct: 733  YNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHLAPDQIPFISKEYAIQLEFAGDYV 792

Query: 1047 EAEYHYLEAQEWKATVNMYRA-SGLWEEAYRVARTQGGAN-AHKHVAYLWAKSLGG---- 1100
             A  HY +        +     +G+ + + R+   + G N A KH + +  +  G     
Sbjct: 793  NALAHYEKGITGDNKEHDEACLAGVAQMSIRMGDIRRGVNQALKHPSRVLKRDCGAILEN 852

Query: 1101 ----EAAVRLLNKLGLLEAAVDHAADNCSFEFAFELSRLALKH-KTPEVHLKYAMFLEDE 1155
                  A +L  K    + A      + ++    +L    L H  +P++HL+YA   E +
Sbjct: 853  MKQFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDL----LPHVSSPKIHLQYAKAKEAD 908

Query: 1156 GKFEEAEAEFIRAGKPKEAVLMFVH--NQDWEAAQRVAEAHDPDSVAEVLVGQARGALEE 1213
            G+++EA   +  A + +  + +++   N   +A   V E    D    V    AR  L+ 
Sbjct: 909  GRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNIVRETQSLDGAKMV----ARFFLQL 964

Query: 1214 KDFQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPSQLEALQEEYEREATKKGA 1273
             D+  A   L+ ++    A    ++     + + I  D + S+ +   E+Y+  A     
Sbjct: 965  GDYGSAIQFLVMSKCNNEAFTLAQQ----HNKMEIYADIIGSE-DTTNEDYQSIALY--F 1017

Query: 1274 RGVEGFVEQARHWEQAGEYSRAVDCYLKVRDS 1305
             G + +++  + +   G+YSRA+  +LK   S
Sbjct: 1018 EGEKRYLQAGKFFLLCGQYSRALKHFLKCPSS 1049


>gi|56243599 WD repeat domain 35 isoform 2 [Homo sapiens]
          Length = 1170

 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 52/264 (19%), Positives = 104/264 (39%), Gaps = 31/264 (11%)

Query: 627 MWKTLSKLALEARQLHIAERCFSALGQVAKARFLHETNEIADQVSREYGGEGTDFYQVRA 686
           +W+ L++ AL+   L+ AE+ F         +F+    ++  +  ++            A
Sbjct: 687 LWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFVKRLGKLLSESMKQ------------A 734

Query: 687 RLAMLEKNYKLAEMIFLEQNAVEEAMGMYQELHRWDECIAVAEAKGHPALEKLRRSYYQW 746
            +      ++ AE  +LE +  + A+G+  +L  W   + + +     A + L       
Sbjct: 735 EVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLE----- 789

Query: 747 LMDTQQEERAGELQESQGDGLAAISLYLKAGLPAKAARLVLTREE----------LLANT 796
               Q     G+    +   L A+  Y++     + A      E+          L  N 
Sbjct: 790 ----QANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPENH 845

Query: 797 ELVEHITAALIKGELYERAGDLFEKIHNPQKALECYRKGNAFMKAVELARLAFPVEVVKL 856
           +L+  I    ++  + E+A   F K   P+ A++     N + KAVELA+     E+  L
Sbjct: 846 KLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSL 905

Query: 857 EEAWGDHLVQQKQLDAAINHYIEA 880
              +  HL+++ +   AI  Y +A
Sbjct: 906 LARYASHLLEKNKTLDAIELYRKA 929



 Score = 45.1 bits (105), Expect = 6e-04
 Identities = 66/253 (26%), Positives = 95/253 (37%), Gaps = 33/253 (13%)

Query: 1043 GRLQEAEYHYLEAQEWKATVNMYRASGLWEEAYRVARTQGGANAHKHVAYLWAKSLGGEA 1102
            GR +EAE  YLE       + +    G W    ++ +T G  +A   +      ++G   
Sbjct: 741  GRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKT-GSGDADDSLLEQANNAIGDYF 799

Query: 1103 AVRL--LNKLGL-LEAAVDHAADNCSF--EFAFELSRLALKHKTPEVHL---KYAMFLED 1154
            A R   LN +   ++         C +  E    L  LA+    PE H    + A     
Sbjct: 800  ADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAIS--LPENHKLLPEIAQMFVR 857

Query: 1155 EGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVGQARGALEEK 1214
             G  E+A   F++  +PK AV   VH   W  A  +A+ H    +  +L   A   LE+ 
Sbjct: 858  VGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKN 917

Query: 1215 DFQKAEGLLLRAQRPGLALNYY------------KEAGLWSDALRICKDYVPSQLEALQE 1262
                A  L  +A       NY+            +EA   S  LR+ K YV   L AL  
Sbjct: 918  KTLDAIELYRKA-------NYFFDAAKLMFKIADEEAKKGSKPLRVKKLYV---LSALLI 967

Query: 1263 EYEREATKKGARG 1275
            E   E  K   RG
Sbjct: 968  EQYHEQMKNAQRG 980



 Score = 40.4 bits (93), Expect = 0.015
 Identities = 18/51 (35%), Positives = 29/51 (56%)

Query: 1416 AALDLYVEQGQWDKCIETATKQNYKILHKYVALYATHLIREGSSAQALALY 1466
            AA+D  V   QW+K +E A   + K +   +A YA+HL+ +  +  A+ LY
Sbjct: 876  AAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELY 926



 Score = 38.5 bits (88), Expect = 0.058
 Identities = 37/168 (22%), Positives = 65/168 (38%), Gaps = 16/168 (9%)

Query: 1216 FQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPSQLEALQEEYEREATKKGARG 1275
            F++AE   L   R  LA+    + G W   L++ K       ++L E+    A       
Sbjct: 743  FEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQ-ANNAIGDYFAD 801

Query: 1276 VEGFVEQARHWEQAGEYSRAVDCYLKVRD-SGNSGLAEKCWMKAAELSIKFLPPQRNMEV 1334
             + ++   +++ Q     R  +CY  + D  G   LA              LP   N ++
Sbjct: 802  RQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAIS------------LP--ENHKL 847

Query: 1335 VLAVGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRVAK 1382
            +  +    + +G    A   +L     K A+D  +   +WNKA  +AK
Sbjct: 848  LPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAK 895



 Score = 35.0 bits (79), Expect = 0.64
 Identities = 38/168 (22%), Positives = 73/168 (43%), Gaps = 23/168 (13%)

Query: 824 NPQKALECYRKGNAFMKAVELARLAFPVEVVKLEEAWGDHLVQQKQLDAAINHYIEARCS 883
           N ++  ECY     + + +E   ++ P E  KL        V+    + A+  +++    
Sbjct: 817 NQERLAECYYMLEDY-EGLENLAISLP-ENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQP 874

Query: 884 IKAIEAALGARQWKKAIYILDLQDRNTASKYYPLVAQHYASLQEYEIAEELYTKGDRTKD 943
             A++  +   QW KA+   +L   ++  +   L+A++ + L E           ++T D
Sbjct: 875 KAAVDTCVHLNQWNKAV---ELAKNHSMKEIGSLLARYASHLLE----------KNKTLD 921

Query: 944 AIDMYTQAGRWEQAHKL--------AMKCMRPEDVSVLYITQAQEMEK 983
           AI++Y +A  +  A KL        A K  +P  V  LY+  A  +E+
Sbjct: 922 AIELYRKANYFFDAAKLMFKIADEEAKKGSKPLRVKKLYVLSALLIEQ 969



 Score = 32.3 bits (72), Expect = 4.2
 Identities = 29/136 (21%), Positives = 57/136 (41%), Gaps = 3/136 (2%)

Query: 859 AWGDHLVQQKQLDAAINHYIEARCSIKAIEAALGARQWKKAIYILDLQDRNTASKYYPLV 918
           A GD+   +++   A+ +Y++ R   +  E       ++    +      N   K  P +
Sbjct: 794 AIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPEN--HKLLPEI 851

Query: 919 AQHYASLQEYEIAEELYTKGDRTKDAIDMYTQAGRWEQAHKLAMKCMRPEDVSVLYITQA 978
           AQ +  +   E A   + K  + K A+D      +W +A +LA K    +++  L    A
Sbjct: 852 AQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELA-KNHSMKEIGSLLARYA 910

Query: 979 QEMEKQGKYREAERLY 994
             + ++ K  +A  LY
Sbjct: 911 SHLLEKNKTLDAIELY 926



 Score = 32.0 bits (71), Expect = 5.4
 Identities = 47/217 (21%), Positives = 88/217 (40%), Gaps = 9/217 (4%)

Query: 977  QAQEMEKQGKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLV----GKHHPDLLSDTH 1032
            QA+ +   G++ EAER Y+ +   DLAI +  K   +  +++L+    G     LL   +
Sbjct: 733  QAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQAN 792

Query: 1033 LHLGKELEAEGRLQEAEYHYLEAQEWKATVNMYRASGLWEEAYRVARTQGGANAHK---H 1089
              +G       +   A  +Y++ +  +     Y     +E    +A +      HK    
Sbjct: 793  NAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISL--PENHKLLPE 850

Query: 1090 VAYLWAKSLGGEAAVRLLNKLGLLEAAVDHAADNCSFEFAFELSRLALKHKTPEVHLKYA 1149
            +A ++ +    E AV    K    +AAVD       +  A EL++     +   +  +YA
Sbjct: 851  IAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYA 910

Query: 1150 MFLEDEGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEA 1186
              L ++ K  +A   + +A    +A  +     D EA
Sbjct: 911  SHLLEKNKTLDAIELYRKANYFFDAAKLMFKIADEEA 947


>gi|55743161 WD repeat domain 35 isoform 1 [Homo sapiens]
          Length = 1181

 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 52/264 (19%), Positives = 104/264 (39%), Gaps = 31/264 (11%)

Query: 627 MWKTLSKLALEARQLHIAERCFSALGQVAKARFLHETNEIADQVSREYGGEGTDFYQVRA 686
           +W+ L++ AL+   L+ AE+ F         +F+    ++  +  ++            A
Sbjct: 698 LWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFVKRLGKLLSESMKQ------------A 745

Query: 687 RLAMLEKNYKLAEMIFLEQNAVEEAMGMYQELHRWDECIAVAEAKGHPALEKLRRSYYQW 746
            +      ++ AE  +LE +  + A+G+  +L  W   + + +     A + L       
Sbjct: 746 EVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLE----- 800

Query: 747 LMDTQQEERAGELQESQGDGLAAISLYLKAGLPAKAARLVLTREE----------LLANT 796
               Q     G+    +   L A+  Y++     + A      E+          L  N 
Sbjct: 801 ----QANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPENH 856

Query: 797 ELVEHITAALIKGELYERAGDLFEKIHNPQKALECYRKGNAFMKAVELARLAFPVEVVKL 856
           +L+  I    ++  + E+A   F K   P+ A++     N + KAVELA+     E+  L
Sbjct: 857 KLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSL 916

Query: 857 EEAWGDHLVQQKQLDAAINHYIEA 880
              +  HL+++ +   AI  Y +A
Sbjct: 917 LARYASHLLEKNKTLDAIELYRKA 940



 Score = 45.1 bits (105), Expect = 6e-04
 Identities = 66/253 (26%), Positives = 95/253 (37%), Gaps = 33/253 (13%)

Query: 1043 GRLQEAEYHYLEAQEWKATVNMYRASGLWEEAYRVARTQGGANAHKHVAYLWAKSLGGEA 1102
            GR +EAE  YLE       + +    G W    ++ +T G  +A   +      ++G   
Sbjct: 752  GRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKT-GSGDADDSLLEQANNAIGDYF 810

Query: 1103 AVRL--LNKLGL-LEAAVDHAADNCSF--EFAFELSRLALKHKTPEVHL---KYAMFLED 1154
            A R   LN +   ++         C +  E    L  LA+    PE H    + A     
Sbjct: 811  ADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAIS--LPENHKLLPEIAQMFVR 868

Query: 1155 EGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVGQARGALEEK 1214
             G  E+A   F++  +PK AV   VH   W  A  +A+ H    +  +L   A   LE+ 
Sbjct: 869  VGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKN 928

Query: 1215 DFQKAEGLLLRAQRPGLALNYY------------KEAGLWSDALRICKDYVPSQLEALQE 1262
                A  L  +A       NY+            +EA   S  LR+ K YV   L AL  
Sbjct: 929  KTLDAIELYRKA-------NYFFDAAKLMFKIADEEAKKGSKPLRVKKLYV---LSALLI 978

Query: 1263 EYEREATKKGARG 1275
            E   E  K   RG
Sbjct: 979  EQYHEQMKNAQRG 991



 Score = 40.4 bits (93), Expect = 0.015
 Identities = 18/51 (35%), Positives = 29/51 (56%)

Query: 1416 AALDLYVEQGQWDKCIETATKQNYKILHKYVALYATHLIREGSSAQALALY 1466
            AA+D  V   QW+K +E A   + K +   +A YA+HL+ +  +  A+ LY
Sbjct: 887  AAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELY 937



 Score = 38.5 bits (88), Expect = 0.058
 Identities = 37/168 (22%), Positives = 65/168 (38%), Gaps = 16/168 (9%)

Query: 1216 FQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPSQLEALQEEYEREATKKGARG 1275
            F++AE   L   R  LA+    + G W   L++ K       ++L E+    A       
Sbjct: 754  FEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQ-ANNAIGDYFAD 812

Query: 1276 VEGFVEQARHWEQAGEYSRAVDCYLKVRD-SGNSGLAEKCWMKAAELSIKFLPPQRNMEV 1334
             + ++   +++ Q     R  +CY  + D  G   LA              LP   N ++
Sbjct: 813  RQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAIS------------LP--ENHKL 858

Query: 1335 VLAVGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRVAK 1382
            +  +    + +G    A   +L     K A+D  +   +WNKA  +AK
Sbjct: 859  LPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAK 906



 Score = 35.0 bits (79), Expect = 0.64
 Identities = 38/168 (22%), Positives = 73/168 (43%), Gaps = 23/168 (13%)

Query: 824 NPQKALECYRKGNAFMKAVELARLAFPVEVVKLEEAWGDHLVQQKQLDAAINHYIEARCS 883
           N ++  ECY     + + +E   ++ P E  KL        V+    + A+  +++    
Sbjct: 828 NQERLAECYYMLEDY-EGLENLAISLP-ENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQP 885

Query: 884 IKAIEAALGARQWKKAIYILDLQDRNTASKYYPLVAQHYASLQEYEIAEELYTKGDRTKD 943
             A++  +   QW KA+   +L   ++  +   L+A++ + L E           ++T D
Sbjct: 886 KAAVDTCVHLNQWNKAV---ELAKNHSMKEIGSLLARYASHLLE----------KNKTLD 932

Query: 944 AIDMYTQAGRWEQAHKL--------AMKCMRPEDVSVLYITQAQEMEK 983
           AI++Y +A  +  A KL        A K  +P  V  LY+  A  +E+
Sbjct: 933 AIELYRKANYFFDAAKLMFKIADEEAKKGSKPLRVKKLYVLSALLIEQ 980



 Score = 32.3 bits (72), Expect = 4.2
 Identities = 29/136 (21%), Positives = 57/136 (41%), Gaps = 3/136 (2%)

Query: 859 AWGDHLVQQKQLDAAINHYIEARCSIKAIEAALGARQWKKAIYILDLQDRNTASKYYPLV 918
           A GD+   +++   A+ +Y++ R   +  E       ++    +      N   K  P +
Sbjct: 805 AIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPEN--HKLLPEI 862

Query: 919 AQHYASLQEYEIAEELYTKGDRTKDAIDMYTQAGRWEQAHKLAMKCMRPEDVSVLYITQA 978
           AQ +  +   E A   + K  + K A+D      +W +A +LA K    +++  L    A
Sbjct: 863 AQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELA-KNHSMKEIGSLLARYA 921

Query: 979 QEMEKQGKYREAERLY 994
             + ++ K  +A  LY
Sbjct: 922 SHLLEKNKTLDAIELY 937



 Score = 32.0 bits (71), Expect = 5.4
 Identities = 47/217 (21%), Positives = 88/217 (40%), Gaps = 9/217 (4%)

Query: 977  QAQEMEKQGKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLV----GKHHPDLLSDTH 1032
            QA+ +   G++ EAER Y+ +   DLAI +  K   +  +++L+    G     LL   +
Sbjct: 744  QAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQAN 803

Query: 1033 LHLGKELEAEGRLQEAEYHYLEAQEWKATVNMYRASGLWEEAYRVARTQGGANAHK---H 1089
              +G       +   A  +Y++ +  +     Y     +E    +A +      HK    
Sbjct: 804  NAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISL--PENHKLLPE 861

Query: 1090 VAYLWAKSLGGEAAVRLLNKLGLLEAAVDHAADNCSFEFAFELSRLALKHKTPEVHLKYA 1149
            +A ++ +    E AV    K    +AAVD       +  A EL++     +   +  +YA
Sbjct: 862  IAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYA 921

Query: 1150 MFLEDEGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEA 1186
              L ++ K  +A   + +A    +A  +     D EA
Sbjct: 922  SHLLEKNKTLDAIELYRKANYFFDAAKLMFKIADEEA 958


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 43.5 bits (101), Expect = 0.002
 Identities = 43/189 (22%), Positives = 77/189 (40%), Gaps = 28/189 (14%)

Query: 73  AFSPDSTKIAIGQTDNIIYVYKIGED--WGDKKVICNKFIQTSA--------VTCLQWPA 122
           A++P S  +A G  D+   ++ + E+   G  +++    I+           VT L W  
Sbjct: 188 AWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNT 247

Query: 123 E-YIIVFGLAEGKVRLANTKTNKSSTIYGTESYVVSLTTNCSGKGILSGHADGTIVRYFF 181
              ++  G  +G  R+     N +ST+   +  + +L  N  G  ILS   D T + +  
Sbjct: 248 NGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIW-- 305

Query: 182 DDEGSGESQGKLVNHPCPPYALAWATNSIVAA------------GCDRKIVAYGKEGHML 229
            D  +GE++ +   H  P   + W  N+  A+            GCDR +  +  +GH  
Sbjct: 306 -DAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTF--QGHTN 362

Query: 230 QTFDYSRDP 238
           +      DP
Sbjct: 363 EVNAIKWDP 371


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 43.5 bits (101), Expect = 0.002
 Identities = 43/189 (22%), Positives = 77/189 (40%), Gaps = 28/189 (14%)

Query: 73  AFSPDSTKIAIGQTDNIIYVYKIGED--WGDKKVICNKFIQTSA--------VTCLQWPA 122
           A++P S  +A G  D+   ++ + E+   G  +++    I+           VT L W  
Sbjct: 188 AWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNT 247

Query: 123 E-YIIVFGLAEGKVRLANTKTNKSSTIYGTESYVVSLTTNCSGKGILSGHADGTIVRYFF 181
              ++  G  +G  R+     N +ST+   +  + +L  N  G  ILS   D T + +  
Sbjct: 248 NGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIW-- 305

Query: 182 DDEGSGESQGKLVNHPCPPYALAWATNSIVAA------------GCDRKIVAYGKEGHML 229
            D  +GE++ +   H  P   + W  N+  A+            GCDR +  +  +GH  
Sbjct: 306 -DAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTF--QGHTN 362

Query: 230 QTFDYSRDP 238
           +      DP
Sbjct: 363 EVNAIKWDP 371


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 43.5 bits (101), Expect = 0.002
 Identities = 43/189 (22%), Positives = 77/189 (40%), Gaps = 28/189 (14%)

Query: 73  AFSPDSTKIAIGQTDNIIYVYKIGED--WGDKKVICNKFIQTSA--------VTCLQWPA 122
           A++P S  +A G  D+   ++ + E+   G  +++    I+           VT L W  
Sbjct: 239 AWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNT 298

Query: 123 E-YIIVFGLAEGKVRLANTKTNKSSTIYGTESYVVSLTTNCSGKGILSGHADGTIVRYFF 181
              ++  G  +G  R+     N +ST+   +  + +L  N  G  ILS   D T + +  
Sbjct: 299 NGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIW-- 356

Query: 182 DDEGSGESQGKLVNHPCPPYALAWATNSIVAA------------GCDRKIVAYGKEGHML 229
            D  +GE++ +   H  P   + W  N+  A+            GCDR +  +  +GH  
Sbjct: 357 -DAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTF--QGHTN 413

Query: 230 QTFDYSRDP 238
           +      DP
Sbjct: 414 EVNAIKWDP 422


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 43.5 bits (101), Expect = 0.002
 Identities = 43/189 (22%), Positives = 77/189 (40%), Gaps = 28/189 (14%)

Query: 73  AFSPDSTKIAIGQTDNIIYVYKIGED--WGDKKVICNKFIQTSA--------VTCLQWPA 122
           A++P S  +A G  D+   ++ + E+   G  +++    I+           VT L W  
Sbjct: 239 AWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNT 298

Query: 123 E-YIIVFGLAEGKVRLANTKTNKSSTIYGTESYVVSLTTNCSGKGILSGHADGTIVRYFF 181
              ++  G  +G  R+     N +ST+   +  + +L  N  G  ILS   D T + +  
Sbjct: 299 NGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIW-- 356

Query: 182 DDEGSGESQGKLVNHPCPPYALAWATNSIVAA------------GCDRKIVAYGKEGHML 229
            D  +GE++ +   H  P   + W  N+  A+            GCDR +  +  +GH  
Sbjct: 357 -DAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTF--QGHTN 413

Query: 230 QTFDYSRDP 238
           +      DP
Sbjct: 414 EVNAIKWDP 422


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 42.7 bits (99), Expect = 0.003
 Identities = 41/189 (21%), Positives = 77/189 (40%), Gaps = 28/189 (14%)

Query: 73  AFSPDSTKIAIGQTDNIIYVYKIGED--WGDKKVICNKFIQTSA--------VTCLQWPA 122
           A++P S  +A G  D+   ++ + E+   G  +++    I+           VT L W +
Sbjct: 186 AWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNS 245

Query: 123 E-YIIVFGLAEGKVRLANTKTNKSSTIYGTESYVVSLTTNCSGKGILSGHADGTIVRYFF 181
           +  ++  G  +G  R+     N +ST+   +  + +L  N  G  +LS   D T + +  
Sbjct: 246 DGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIW-- 303

Query: 182 DDEGSGESQGKLVNHPCPPYALAWATNSIVAA------------GCDRKIVAYGKEGHML 229
            D  +GE++ +   H  P   + W  N   A+            GCD  +  +  +GH  
Sbjct: 304 -DAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTF--QGHTN 360

Query: 230 QTFDYSRDP 238
           +      DP
Sbjct: 361 EVNAIKWDP 369


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 42.7 bits (99), Expect = 0.003
 Identities = 41/189 (21%), Positives = 77/189 (40%), Gaps = 28/189 (14%)

Query: 73  AFSPDSTKIAIGQTDNIIYVYKIGED--WGDKKVICNKFIQTSA--------VTCLQWPA 122
           A++P S  +A G  D+   ++ + E+   G  +++    I+           VT L W +
Sbjct: 186 AWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNS 245

Query: 123 E-YIIVFGLAEGKVRLANTKTNKSSTIYGTESYVVSLTTNCSGKGILSGHADGTIVRYFF 181
           +  ++  G  +G  R+     N +ST+   +  + +L  N  G  +LS   D T + +  
Sbjct: 246 DGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIW-- 303

Query: 182 DDEGSGESQGKLVNHPCPPYALAWATNSIVAA------------GCDRKIVAYGKEGHML 229
            D  +GE++ +   H  P   + W  N   A+            GCD  +  +  +GH  
Sbjct: 304 -DAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTF--QGHTN 360

Query: 230 QTFDYSRDP 238
           +      DP
Sbjct: 361 EVNAIKWDP 369


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 42.7 bits (99), Expect = 0.003
 Identities = 41/189 (21%), Positives = 77/189 (40%), Gaps = 28/189 (14%)

Query: 73  AFSPDSTKIAIGQTDNIIYVYKIGED--WGDKKVICNKFIQTSA--------VTCLQWPA 122
           A++P S  +A G  D+   ++ + E+   G  +++    I+           VT L W +
Sbjct: 186 AWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNS 245

Query: 123 E-YIIVFGLAEGKVRLANTKTNKSSTIYGTESYVVSLTTNCSGKGILSGHADGTIVRYFF 181
           +  ++  G  +G  R+     N +ST+   +  + +L  N  G  +LS   D T + +  
Sbjct: 246 DGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIW-- 303

Query: 182 DDEGSGESQGKLVNHPCPPYALAWATNSIVAA------------GCDRKIVAYGKEGHML 229
            D  +GE++ +   H  P   + W  N   A+            GCD  +  +  +GH  
Sbjct: 304 -DAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTF--QGHTN 360

Query: 230 QTFDYSRDP 238
           +      DP
Sbjct: 361 EVNAIKWDP 369


>gi|5031601 actin related protein 2/3 complex subunit 1B [Homo
           sapiens]
          Length = 372

 Score = 42.0 bits (97), Expect = 0.005
 Identities = 27/103 (26%), Positives = 51/103 (49%), Gaps = 10/103 (9%)

Query: 19  VTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGRKSYMVKGMAFSPDS 78
           ++C AW+++  + A+C  +  V +Y++ G +     TK  ++K    +  V G+ ++P+S
Sbjct: 11  ISCHAWNKDRTQIAICPNNHEVHIYEKSGAK----WTKVHELK--EHNGQVTGIDWAPES 64

Query: 79  TKIAIGQTDNIIYVYKI-GEDWGDKKVICNKFIQTSAVTCLQW 120
            +I    TD   YV+ + G  W    VI        A  C++W
Sbjct: 65  NRIVTCGTDRNAYVWTLKGRTWKPTLVILR---INRAARCVRW 104


>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
           isoform a [Homo sapiens]
          Length = 353

 Score = 41.6 bits (96), Expect = 0.007
 Identities = 53/249 (21%), Positives = 85/249 (34%), Gaps = 58/249 (23%)

Query: 18  KVTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGRKSYMVKGMAFSPD 77
           KV CM W ++  +    + D  V+++D     ++   T P           V   A++P 
Sbjct: 65  KVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCT--------WVMACAYAPS 116

Query: 78  STKIAIGQTDNIIYVYKIGEDWGDKKVICNKFIQTSAVTCLQWPAEYIIVFGLAEGKVRL 137
              IA G  DN   VY +  D  +                                    
Sbjct: 117 GCAIACGGLDNKCSVYPLTFDKNE------------------------------------ 140

Query: 138 ANTKTNKSSTIYGTESYVVSLTTNCSGKGILSGHADGTIVRYFFDDEGSGESQGKLVNHP 197
            N    K S    T +Y+ + +   S   IL+   DGT   +   D  SG+       H 
Sbjct: 141 -NMAAKKKSVAMHT-NYLSACSFTNSDMQILTASGDGTCALW---DVESGQLLQSFHGHG 195

Query: 198 ----CPPYALAWATNSIVAAGCDRKIVAYG-KEGHMLQTFDYSRDPQEREFTTAVSSPGG 252
               C   A +   N+ V+ GCD+K + +  + G  +Q F    +  E +  +    P G
Sbjct: 196 ADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAF----ETHESDINSVRYYPSG 251

Query: 253 QSVVLGSYD 261
            +   GS D
Sbjct: 252 DAFASGSDD 260


>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
           isoform b [Homo sapiens]
          Length = 395

 Score = 41.6 bits (96), Expect = 0.007
 Identities = 53/249 (21%), Positives = 85/249 (34%), Gaps = 58/249 (23%)

Query: 18  KVTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGRKSYMVKGMAFSPD 77
           KV CM W ++  +    + D  V+++D     ++   T P           V   A++P 
Sbjct: 107 KVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCT--------WVMACAYAPS 158

Query: 78  STKIAIGQTDNIIYVYKIGEDWGDKKVICNKFIQTSAVTCLQWPAEYIIVFGLAEGKVRL 137
              IA G  DN   VY +  D  +                                    
Sbjct: 159 GCAIACGGLDNKCSVYPLTFDKNE------------------------------------ 182

Query: 138 ANTKTNKSSTIYGTESYVVSLTTNCSGKGILSGHADGTIVRYFFDDEGSGESQGKLVNHP 197
            N    K S    T +Y+ + +   S   IL+   DGT   +   D  SG+       H 
Sbjct: 183 -NMAAKKKSVAMHT-NYLSACSFTNSDMQILTASGDGTCALW---DVESGQLLQSFHGHG 237

Query: 198 ----CPPYALAWATNSIVAAGCDRKIVAYG-KEGHMLQTFDYSRDPQEREFTTAVSSPGG 252
               C   A +   N+ V+ GCD+K + +  + G  +Q F    +  E +  +    P G
Sbjct: 238 ADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAF----ETHESDINSVRYYPSG 293

Query: 253 QSVVLGSYD 261
            +   GS D
Sbjct: 294 DAFASGSDD 302


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 41.6 bits (96), Expect = 0.007
 Identities = 36/152 (23%), Positives = 68/152 (44%), Gaps = 14/152 (9%)

Query: 73  AFSPDSTKIAIGQTDNIIYVYKIGEDW--GDKKVICNKFIQTSA--------VTCLQWPA 122
           A++P S  +A G  D+   ++ + E+   G  +++    I+           VT L W +
Sbjct: 176 AWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNS 235

Query: 123 E-YIIVFGLAEGKVRLANTKTNKSSTIYGTESYVVSLTTNCSGKGILSGHADGTIVRYFF 181
           E  ++  G  +G  R+     N +ST+   +  + +L  N  G  ILS   D T + +  
Sbjct: 236 EGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIW-- 293

Query: 182 DDEGSGESQGKLVNHPCPPYALAWATNSIVAA 213
            D  +GE++ +   H  P   + W +N+  A+
Sbjct: 294 -DAHTGEAKQQFPFHSAPALDVDWQSNNTFAS 324


>gi|110347568 centrosomal protein 152kDa [Homo sapiens]
          Length = 1654

 Score = 41.6 bits (96), Expect = 0.007
 Identities = 41/167 (24%), Positives = 74/167 (44%), Gaps = 15/167 (8%)

Query: 1250 KDYVPSQLEALQEEYEREATK---KGARGVEGFVEQARHWEQAGEYSRAVDCYLKVRDSG 1306
            KD+V  QLE  QE  + E T+   K  R +E   +Q  H  Q+G          +++   
Sbjct: 399  KDHV-KQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQ-- 455

Query: 1307 NSGLAEKCWMKAAELSIKFLPPQRNMEVVLAVGPQLIGIGKHSAAAELYLNLDLVKEAID 1366
                A+K    +A ++         ++  +++      +G H + +E  LN++L +  +D
Sbjct: 456  ----AQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVD 511

Query: 1367 AFIEGEEWNKAK--RVAKELDPRYEDYVDQHYKEFLKNQGKVDSLVG 1411
              I+   W K+K   + +E DP  E   D+     LK + +V  L+G
Sbjct: 512  LGIKKVNWKKSKVTSIVQEEDPNEELSKDEF---ILKLKAEVQRLLG 555


>gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens]
          Length = 367

 Score = 40.8 bits (94), Expect = 0.012
 Identities = 22/78 (28%), Positives = 45/78 (57%), Gaps = 7/78 (8%)

Query: 18  KVTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGRKSYMVKGMAFSPD 77
           ++T +A    +++F   + DR+V+++D HG      S++P     G  + +V G+A SPD
Sbjct: 105 EITKVACIPKSSQFFSASRDRMVMMWDLHG------SSQPRQQLCGH-AMVVTGLAVSPD 157

Query: 78  STKIAIGQTDNIIYVYKI 95
           S+++  G  DN + ++ +
Sbjct: 158 SSQLCTGSRDNTLLLWDV 175


>gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens]
          Length = 366

 Score = 40.8 bits (94), Expect = 0.012
 Identities = 22/78 (28%), Positives = 45/78 (57%), Gaps = 7/78 (8%)

Query: 18  KVTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGRKSYMVKGMAFSPD 77
           ++T +A    +++F   + DR+V+++D HG      S++P     G  + +V G+A SPD
Sbjct: 104 EITKVACIPKSSQFFSASRDRMVMMWDLHG------SSQPRQQLCGH-AMVVTGLAVSPD 156

Query: 78  STKIAIGQTDNIIYVYKI 95
           S+++  G  DN + ++ +
Sbjct: 157 SSQLCTGSRDNTLLLWDV 174


>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
           [Homo sapiens]
          Length = 340

 Score = 38.9 bits (89), Expect = 0.044
 Identities = 53/272 (19%), Positives = 102/272 (37%), Gaps = 28/272 (10%)

Query: 6   LRTLLSPQDGAAKVTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGRK 65
           +RT  + +   AK+  M W  ++      + D  ++++D +    +K    P       +
Sbjct: 45  MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSY--TTNKVHAIPL------R 96

Query: 66  SYMVKGMAFSPDSTKIAIGQTDNIIYVYKIGEDWGDKKVICNKFIQTSAVTCLQWPAEYI 125
           S  V   A++P    +A G  DNI  +Y +    G+ +V       T  ++C ++  +  
Sbjct: 97  SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ 156

Query: 126 IVFGLAEGKVRLANTKTNKSSTIY-GTESYVVSLTTNCSGKGILSGHADGTIVRYFFDDE 184
           IV    +    L + +T + +T + G    V+SL+     +  +SG  D +   +   D 
Sbjct: 157 IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW---DV 213

Query: 185 GSGESQGKLVNHPCPPYALAWATNSIVAAGCDRKIVAYGKEGHMLQTFDYSRDPQEREFT 244
             G  +     H     A+ +  N            A G +    + FD   D +   ++
Sbjct: 214 REGMCRQTFTGHESDINAICFFPNG--------NAFATGSDDATCRLFDLRADQELMTYS 265

Query: 245 --------TAVSSPGGQSVVLGSYDRLRVFNW 268
                   T+VS      ++L  YD      W
Sbjct: 266 HDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 297


>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
           [Homo sapiens]
          Length = 340

 Score = 38.9 bits (89), Expect = 0.044
 Identities = 36/172 (20%), Positives = 74/172 (43%), Gaps = 9/172 (5%)

Query: 6   LRTLLSPQDGAAKVTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGRK 65
           +RT  + +   AK+  M W  ++      + D  ++++D +    +K    P       +
Sbjct: 45  MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSY--TTNKVHAIPL------R 96

Query: 66  SYMVKGMAFSPDSTKIAIGQTDNIIYVYKIGEDWGDKKVICNKFIQTSAVTCLQWPAEYI 125
           S  V   A++P    +A G  DNI  +Y +    G+ +V       T  ++C ++  +  
Sbjct: 97  SSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQ 156

Query: 126 IVFGLAEGKVRLANTKTNKSSTIY-GTESYVVSLTTNCSGKGILSGHADGTI 176
           I+    +    L + +T + +  + G    V+SL+    G+  +SG  D +I
Sbjct: 157 IITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASI 208


>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
           [Homo sapiens]
          Length = 340

 Score = 38.5 bits (88), Expect = 0.058
 Identities = 36/171 (21%), Positives = 74/171 (43%), Gaps = 9/171 (5%)

Query: 6   LRTLLSPQDGAAKVTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGRK 65
           +RT  + +   AK+  M W  ++      + D  ++++D +    +K    P       +
Sbjct: 45  MRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSY--TTNKMHAIPL------R 96

Query: 66  SYMVKGMAFSPDSTKIAIGQTDNIIYVYKIGEDWGDKKVICNKFIQTSAVTCLQWPAEYI 125
           S  V   A++P    +A G  DNI  +Y +    G+ +V       T  ++C ++  +  
Sbjct: 97  SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQ 156

Query: 126 IVFGLAEGKVRLANTKTNKSSTIY-GTESYVVSLTTNCSGKGILSGHADGT 175
           IV    +    L + +T + +T + G    V+SL+ +   +  +SG  D +
Sbjct: 157 IVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDAS 207


>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
           sapiens]
          Length = 340

 Score = 38.5 bits (88), Expect = 0.058
 Identities = 35/171 (20%), Positives = 72/171 (42%), Gaps = 9/171 (5%)

Query: 6   LRTLLSPQDGAAKVTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGRK 65
           +RT  + +   AK+  M W+ ++      + D  ++++D +    +K    P       +
Sbjct: 45  MRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSY--TTNKVHAIPL------R 96

Query: 66  SYMVKGMAFSPDSTKIAIGQTDNIIYVYKIGEDWGDKKVICNKFIQTSAVTCLQWPAEYI 125
           S  V   A++P    +A G  DN+  +Y +    G+ KV       T  ++C ++  +  
Sbjct: 97  SSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNN 156

Query: 126 IVFGLAEGKVRLANTKTNKSSTIY-GTESYVVSLTTNCSGKGILSGHADGT 175
           IV    +    L + +T +  T++ G     +SL  +      +SG  D +
Sbjct: 157 IVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDAS 207


>gi|212276078 leucine rich repeat (in FLII) interacting protein 1
           isoform 1 [Homo sapiens]
          Length = 640

 Score = 37.0 bits (84), Expect = 0.17
 Identities = 50/209 (23%), Positives = 81/209 (38%), Gaps = 26/209 (12%)

Query: 655 AKARFLHETNEIADQVSREYGGEGTDFYQVRARLAMLEKNYKLAEMIFLEQNAVEEAMGM 714
           A  R + E NE+ DQ+    G       +++  LA +E+ YK A M+   Q   E+   M
Sbjct: 259 ASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKA-MVSNAQLDNEKTNFM 317

Query: 715 YQELHRWDECIAVAEAKGHPALEKLRRSYYQWLMDTQQEERAGELQESQGDGLAAISLYL 774
           YQ     D  + + E      L + RR Y +   + ++E+ A  + + Q           
Sbjct: 318 YQVDTLKDMLLELEE-----QLAESRRQYEEKNKEFEREKHAHSILQFQF---------- 362

Query: 775 KAGLPAKAARLVLTREELLANTELVEHITAALIKGELYERAGDLFEKIHNPQKALECYRK 834
                A+    +  REE+L     ++   A+ I+        DL E I    K +    +
Sbjct: 363 -----AEVKEALKQREEMLEEIRQLQQKQASSIR-----EISDLQETIEWKDKKIGALER 412

Query: 835 GNAFMKAVELARLAFPVEVVKLEEAWGDH 863
              F  +V   R     EVV L+E    H
Sbjct: 413 QKEFFDSVRSERDDLREEVVMLKEELKKH 441


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,639,900
Number of Sequences: 37866
Number of extensions: 2722707
Number of successful extensions: 8172
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 7907
Number of HSP's gapped (non-prelim): 259
length of query: 1749
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1633
effective length of database: 13,855,062
effective search space: 22625316246
effective search space used: 22625316246
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.