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Search of human proteins with 13129098
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13129098 ankyrin repeat and SOCS box-containing 8 [Homo
sapiens]
(288 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13129098 ankyrin repeat and SOCS box-containing 8 [Homo sapiens] 578 e-165
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 94 1e-19
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 94 2e-19
gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [H... 91 2e-18
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 90 3e-18
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 87 2e-17
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 87 2e-17
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 87 2e-17
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 87 2e-17
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 87 2e-17
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 86 5e-17
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 86 5e-17
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 85 6e-17
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 85 6e-17
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 85 6e-17
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 85 6e-17
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 84 1e-16
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 83 2e-16
gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isof... 83 3e-16
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 83 3e-16
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 83 3e-16
gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [H... 82 4e-16
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 82 5e-16
gi|20270347 ankyrin repeat domain 54 [Homo sapiens] 82 5e-16
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 82 7e-16
gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens] 82 7e-16
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 81 1e-15
gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1 [... 80 2e-15
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 80 2e-15
gi|22208964 ankyrin repeat and SOCS box-containing protein 4 iso... 80 2e-15
>gi|13129098 ankyrin repeat and SOCS box-containing 8 [Homo sapiens]
Length = 288
Score = 578 bits (1489), Expect = e-165
Identities = 288/288 (100%), Positives = 288/288 (100%)
Query: 1 MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCA 60
MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCA
Sbjct: 1 MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCA 60
Query: 61 CMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDT 120
CMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDT
Sbjct: 61 CMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDT 120
Query: 121 PLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVI 180
PLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVI
Sbjct: 121 PLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVI 180
Query: 181 NLIGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREVARDPQLCEKL 240
NLIGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREVARDPQLCEKL
Sbjct: 181 NLIGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREVARDPQLCEKL 240
Query: 241 TVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE 288
TVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE
Sbjct: 241 TVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE 288
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 94.4 bits (233), Expect = 1e-19
Identities = 60/163 (36%), Positives = 81/163 (49%), Gaps = 2/163 (1%)
Query: 28 AIRSFPHDNVEDLIRGGADVNCTHGTLK-PLHCACMVSDADCVELLLEKGAEVNALDGYN 86
A+ S + V+ L++ ADVN + PLH A C E L+ + VN D
Sbjct: 81 AVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAG 140
Query: 87 RTALHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVN 145
RTALH+AA V++LL GAN NA D +HWAA+ + E V+ L+ GA V
Sbjct: 141 RTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVT 200
Query: 146 ALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
D + TPL AA G + V LLD G ++ N G TP+
Sbjct: 201 CKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPL 243
Score = 93.6 bits (231), Expect = 2e-19
Identities = 60/154 (38%), Positives = 82/154 (53%), Gaps = 2/154 (1%)
Query: 37 VEDLIRGGADVNCTHGT-LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA- 94
+E LI GA VN L PLH A + V++LL+ A+VNA D +T LH AA
Sbjct: 57 IELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAA 116
Query: 95 EKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTP 154
K C E L+ +N N D T LH AAF + E V+ LL GA++NA D +
Sbjct: 117 NKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRA 176
Query: 155 LSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
+ WAA G++E V +L+ +GAEV + TP+
Sbjct: 177 IHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPL 210
Score = 81.6 bits (200), Expect = 7e-16
Identities = 52/126 (41%), Positives = 68/126 (53%), Gaps = 4/126 (3%)
Query: 37 VEDLIRGGADV--NCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA 94
+ LI GAD HG PLH A + +DC LL G +++ D + RT LH AA
Sbjct: 355 INTLITSGADTAKRGIHGMF-PLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAA 413
Query: 95 EKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDT 153
C+ +LL GA+ N D +PLH+AA N +C+ AL+ SGASVN LD T
Sbjct: 414 AGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCT 473
Query: 154 PLSWAA 159
PL +AA
Sbjct: 474 PLHYAA 479
Score = 73.6 bits (179), Expect = 2e-13
Identities = 51/161 (31%), Positives = 84/161 (52%), Gaps = 6/161 (3%)
Query: 34 HDNVEDLIRGGADVNCTHGTLK-PLHCACMVSDADCVELLLEKGAEVNALDGY-NRTALH 91
H +E L++ D++ + + + PL A +CV++L+ +GA + D RT +H
Sbjct: 563 HQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIH 622
Query: 92 YAAEKDEA-CVEVLLEYGANPNALD---GNRDTPLHWAAFKNNAECVRALLESGASVNAL 147
AA + C+ +L+ NA+D GN TPL + + +CV +LL GA+V+A
Sbjct: 623 AAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAK 682
Query: 148 DYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
D T L A+ G+ E V LL +GA+ + + G+TPI
Sbjct: 683 DKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPI 723
Score = 72.4 bits (176), Expect = 4e-13
Identities = 47/122 (38%), Positives = 65/122 (53%), Gaps = 5/122 (4%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKD-EACVEVLLEYGANPNAL 114
PL + + DCV LL KGA V+A D + RTALH A E CV+ LL++GA
Sbjct: 656 PLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLR 715
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNA----LDYNNDTPLSWAAMKGNLESVSIL 170
D TP+H +A + + ALL+S AS++A D + T L WA G+ V +L
Sbjct: 716 DSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL 775
Query: 171 LD 172
L+
Sbjct: 776 LE 777
Score = 72.0 bits (175), Expect = 6e-13
Identities = 48/133 (36%), Positives = 67/133 (50%), Gaps = 1/133 (0%)
Query: 57 LHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALD 115
LH A + V+LLL +GA +NA D +R A+H+AA V++L+ +GA D
Sbjct: 144 LHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKD 203
Query: 116 GNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGA 175
TPLH AA V+ LL+ G +N + +TPL A G V+ L+D GA
Sbjct: 204 KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263
Query: 176 EVRVINLIGQTPI 188
V N G TP+
Sbjct: 264 IVNQKNEKGFTPL 276
Score = 69.3 bits (168), Expect = 4e-12
Identities = 47/118 (39%), Positives = 63/118 (53%), Gaps = 4/118 (3%)
Query: 57 LHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKD-EACVEVLLE-YGAN-PNA 113
LH AC CVELLLE+ +G + LH A D E E+L++ GA+ NA
Sbjct: 760 LHWACYNGHETCVELLLEQEV-FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNA 818
Query: 114 LDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILL 171
D TPLH AAF ++ EC++ LL A VN++D TPL AA G +V +L+
Sbjct: 819 TDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLV 876
Score = 68.2 bits (165), Expect = 8e-12
Identities = 49/154 (31%), Positives = 75/154 (48%), Gaps = 2/154 (1%)
Query: 37 VEDLIRGGADVNCTHGTLK-PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAE 95
+E L+ GADVN K PLH + + +++ GA ++ D T LH AA
Sbjct: 289 LELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAAR 348
Query: 96 KD-EACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTP 154
E + L+ GA+ + PLH AA ++C R LL SG ++ D T
Sbjct: 349 YGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTC 408
Query: 155 LSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
L AA GNLE +++LL+ GA+ + G++P+
Sbjct: 409 LHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPL 442
Score = 67.0 bits (162), Expect = 2e-11
Identities = 54/180 (30%), Positives = 90/180 (50%), Gaps = 5/180 (2%)
Query: 14 SKYSLSERLIRTIAAIRSFPH--DNVEDLIRGGADVNC-THGTLKPLHCACMVSDADCVE 70
S ++S+R RT +F + V+ L+ GA++N + +H A + + V+
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190
Query: 71 LLLEKGAEVNALDGYNRTALHYAAEKDE-ACVEVLLEYGANPNALDGNRDTPLHWAAFKN 129
LL+ GAEV D + T LH AA + V+ LL+ G + N + +TPLH A +
Sbjct: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
Query: 130 NAECVRALLESGASVNALDYNNDTPLSWAAMKGN-LESVSILLDYGAEVRVINLIGQTPI 188
V L++ GA VN + TPL +AA + + +L+ GA+V + + G+TP+
Sbjct: 251 QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
Score = 67.0 bits (162), Expect = 2e-11
Identities = 43/135 (31%), Positives = 66/135 (48%), Gaps = 2/135 (1%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA--CVEVLLEYGANPNA 113
PLH AC V L++ GA VN + T LH+AA C+E+L+ GA+ N
Sbjct: 242 PLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNM 301
Query: 114 LDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDY 173
+ TPLH A + +++SGA ++ D N +TPL AA G+ ++ L+
Sbjct: 302 KSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS 361
Query: 174 GAEVRVINLIGQTPI 188
GA+ + G P+
Sbjct: 362 GADTAKRGIHGMFPL 376
Score = 67.0 bits (162), Expect = 2e-11
Identities = 46/143 (32%), Positives = 74/143 (51%), Gaps = 5/143 (3%)
Query: 53 TLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANP 111
T+ PLH A +E+L++ +++ + RT L AA K CV+VL+ GA+
Sbjct: 550 TISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI 609
Query: 112 NALDGN-RDTPLHWAAFKNNAECVRALLESGASVNALDY---NNDTPLSWAAMKGNLESV 167
D + TP+H AA ++EC+R L+ + NA+D N TPL + + G+ + V
Sbjct: 610 LVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCV 669
Query: 168 SILLDYGAEVRVINLIGQTPISR 190
LL+ GA V + G+T + R
Sbjct: 670 YSLLNKGANVDAKDKWGRTALHR 692
Score = 65.9 bits (159), Expect = 4e-11
Identities = 47/125 (37%), Positives = 63/125 (50%), Gaps = 1/125 (0%)
Query: 65 DADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLH 123
D D V L+ K +VN D RT LH AA +A +E+L+ GA NA D TPLH
Sbjct: 20 DPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLH 79
Query: 124 WAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLI 183
A + E V+ LL+ A VNA D N TPL AA ++ L+ + V V +
Sbjct: 80 RAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRA 139
Query: 184 GQTPI 188
G+T +
Sbjct: 140 GRTAL 144
Score = 65.9 bits (159), Expect = 4e-11
Identities = 58/198 (29%), Positives = 85/198 (42%), Gaps = 49/198 (24%)
Query: 40 LIRGGADVNCTHGTLK-PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA--EK 96
L+ GAD N + PLH A + C+ L+ GA VN LD T LHYAA +
Sbjct: 424 LLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDT 483
Query: 97 DEACVEVLLEYGANPNALD----------------------------------------- 115
D C+E LL ANP D
Sbjct: 484 DGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLS 543
Query: 116 --GNRDT--PLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILL 171
NR T PLH AA+ + + + L++S ++ + + TPL AA KG++E V +L+
Sbjct: 544 DSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLI 603
Query: 172 DYGAEVRVIN-LIGQTPI 188
+ GA + V + ++ +TPI
Sbjct: 604 NQGASILVKDYILKRTPI 621
Score = 65.5 bits (158), Expect = 5e-11
Identities = 50/151 (33%), Positives = 72/151 (47%), Gaps = 6/151 (3%)
Query: 43 GGADVNCTHGTLK-PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-C 100
G + VN T + PLH A +C++LLL A+VN++D +T L AAE +
Sbjct: 812 GASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNT 871
Query: 101 VEVLLEYGANPNAL-DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNN---DTPLS 156
VE+L+ + L D +++T LH A K + +LE N ++ N TPL
Sbjct: 872 VEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLH 931
Query: 157 WAAMKGNLESVSILLDYGAEVRVINLIGQTP 187
AA G V LL GA V ++ G TP
Sbjct: 932 VAARNGLTMVVQELLGKGASVLAVDENGYTP 962
Score = 60.1 bits (144), Expect = 2e-09
Identities = 48/147 (32%), Positives = 67/147 (45%), Gaps = 6/147 (4%)
Query: 37 VEDLIRGGADVNCTHGTLK--PLHCACMVSDADCVELLLEKGAEVNALD---GYNRTALH 91
V+ LI GA + LK P+H A ++C+ LL+ NA+D G +T L
Sbjct: 599 VDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLM 658
Query: 92 YAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYN 150
+ CV LL GAN +A D T LH A + ECV ALL+ GA D
Sbjct: 659 LSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSR 718
Query: 151 NDTPLSWAAMKGNLESVSILLDYGAEV 177
TP+ +A G++ + LL A +
Sbjct: 719 GRTPIHLSAACGHIGVLGALLQSAASM 745
Score = 58.9 bits (141), Expect = 5e-09
Identities = 46/153 (30%), Positives = 68/153 (44%), Gaps = 2/153 (1%)
Query: 38 EDLIRGGADVNCTHGTLK-PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEK 96
+ +I+ GA ++C PLH A + L+ GA+ + LH AA
Sbjct: 323 QTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALS 382
Query: 97 DEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPL 155
+ C LL G + + D T LH AA N EC+ LL +GA N D +PL
Sbjct: 383 GFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPL 442
Query: 156 SWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
+AA N + + L+ GA V ++ G TP+
Sbjct: 443 HYAAANCNYQCLFALVGSGASVNDLDERGCTPL 475
Score = 39.7 bits (91), Expect = 0.003
Identities = 29/77 (37%), Positives = 38/77 (49%), Gaps = 1/77 (1%)
Query: 118 RDTP-LHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAE 176
RD P L A F + + VRAL+ VN D TPL AA G+ E + +L+ GA
Sbjct: 7 RDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGAR 66
Query: 177 VRVINLIGQTPISRLVA 193
V + TP+ R VA
Sbjct: 67 VNAKDSKWLTPLHRAVA 83
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 93.6 bits (231), Expect = 2e-19
Identities = 59/154 (38%), Positives = 84/154 (54%), Gaps = 2/154 (1%)
Query: 37 VEDLIRGGADVNCTHGT-LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA- 94
+E LI GA VN L PLH A + V++L++ A+VNA D +T LH AA
Sbjct: 32 IELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAA 91
Query: 95 EKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTP 154
K C EV++ ++ N D T LH AA + E V LL GA++NA D +
Sbjct: 92 NKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRA 151
Query: 155 LSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
L WAA G+L+ V++L+++GAEV + G TP+
Sbjct: 152 LHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPL 185
Score = 92.0 bits (227), Expect = 5e-19
Identities = 60/163 (36%), Positives = 80/163 (49%), Gaps = 2/163 (1%)
Query: 28 AIRSFPHDNVEDLIRGGADVNCTHGTLK-PLHCACMVSDADCVELLLEKGAEVNALDGYN 86
A+ S + V+ LI+ ADVN + PLH A C E+++ + VN D
Sbjct: 56 AVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGG 115
Query: 87 RTALHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVN 145
RTALH+AA V +LL GAN NA D LHWAA+ + + V L+ GA V
Sbjct: 116 RTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT 175
Query: 146 ALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
D TPL AA G + V LL+ G E+ IN+ G T +
Sbjct: 176 CKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTAL 218
Score = 70.5 bits (171), Expect = 2e-12
Identities = 62/226 (27%), Positives = 94/226 (41%), Gaps = 18/226 (7%)
Query: 37 VEDLIRGGADVNCTHGTLK-PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAE 95
+E L+ GADVN K PLH + + L++ G E++ +D T LH AA
Sbjct: 264 LELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAAR 323
Query: 96 KD-EACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTP 154
E + L GA+ + PLH AA +++C R LL SG ++ D T
Sbjct: 324 YGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTC 383
Query: 155 LSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVA---------LLVRGLGTEKED 205
L AA GN+E + +L GA+ + G+TP+ A L+ G + D
Sbjct: 384 LHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETD 443
Query: 206 SCFELLHRAVGHFELRKNGTM-------PREVARDPQLCEKLTVLC 244
++ +N T+ E+ R +L EK LC
Sbjct: 444 DWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLC 489
Score = 66.6 bits (161), Expect = 2e-11
Identities = 43/119 (36%), Positives = 63/119 (52%), Gaps = 1/119 (0%)
Query: 71 LLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKN 129
+L+ K +VN LD RT LH AA +A +E+L+ GA NA D TPLH A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 130 NAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
+ E V+ L++ A VNA D N TPL AA ++ +++ + V V + G+T +
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
Score = 63.9 bits (154), Expect = 2e-10
Identities = 47/152 (30%), Positives = 76/152 (50%), Gaps = 3/152 (1%)
Query: 40 LIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE 98
L+ GA++N + LH A + D V LL+ GAEV D T LH AA +
Sbjct: 134 LLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQ 193
Query: 99 A-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSW 157
V+ LL G + ++ +T LH A + V L++ GA+VN + N TPL +
Sbjct: 194 INVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHF 253
Query: 158 AAMKGN-LESVSILLDYGAEVRVINLIGQTPI 188
AA + + +L++ GA+V + + G++P+
Sbjct: 254 AAASTHGALCLELLVNNGADVNIQSKDGKSPL 285
Score = 63.9 bits (154), Expect = 2e-10
Identities = 54/198 (27%), Positives = 75/198 (37%), Gaps = 65/198 (32%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKD------------------ 97
PLH A C+E L+ GA VN D + RTALHYAA D
Sbjct: 416 PLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEEL 475
Query: 98 -----------EACVEVLLEYGANPNALD------------------------------- 115
C+E LL+ ANP+ D
Sbjct: 476 ERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFE 535
Query: 116 ----GNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILL 171
G +PLH AA+ + + + LL+S ++ D T L AA KG+ E V L+
Sbjct: 536 ESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALI 595
Query: 172 DYGAEVRV-INLIGQTPI 188
+ GA + V N+ +TP+
Sbjct: 596 NPGASIFVKDNVTKRTPL 613
Score = 63.9 bits (154), Expect = 2e-10
Identities = 46/122 (37%), Positives = 64/122 (52%), Gaps = 8/122 (6%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNAL 114
PLH AC + +C+E+LLE+ G T LH A D C +LL GA +++
Sbjct: 750 PLHWACYNGNENCIEVLLEQKC-FRKFIGNPFTPLHCAIINDHGNCASLLL--GAIDSSI 806
Query: 115 DGNRD----TPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSIL 170
RD TPL AAF ++ EC++ LL A VNA+D + T L AA G +V IL
Sbjct: 807 VSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL 866
Query: 171 LD 172
++
Sbjct: 867 VN 868
Score = 60.8 bits (146), Expect = 1e-09
Identities = 45/157 (28%), Positives = 71/157 (45%), Gaps = 9/157 (5%)
Query: 57 LHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA--CVEVLLEYGANPNAL 114
LH AC V L++ GA VN + T LH+AA C+E+L+ GA+ N
Sbjct: 218 LHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQ 277
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ +PLH A + L+++G ++ +D + +TPL AA G+ ++ L G
Sbjct: 278 SKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSG 337
Query: 175 AEVRVINLIGQTPISRLVALLVRGLGTEKEDSCFELL 211
A+ + P+ L AL D C +LL
Sbjct: 338 ADTAKCGIHSMFPL-HLAAL------NAHSDCCRKLL 367
Score = 60.8 bits (146), Expect = 1e-09
Identities = 45/170 (26%), Positives = 67/170 (39%), Gaps = 38/170 (22%)
Query: 57 LHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEAC-VEVLLEYGANPNAL- 114
LH M +CV++LLE+ + D RT LHYAA + A + LL+ +
Sbjct: 682 LHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCC 741
Query: 115 --DGNRDTPLHWAAFKNNAECVRALLES-------------------------------- 140
D TPLHWA + N C+ LLE
Sbjct: 742 FKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGA 801
Query: 141 --GASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
+ V+ D TPL AA ++E + +LL + A V ++ G+T +
Sbjct: 802 IDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTAL 851
Score = 60.1 bits (144), Expect = 2e-09
Identities = 51/168 (30%), Positives = 72/168 (42%), Gaps = 18/168 (10%)
Query: 57 LHCACMVSDADCVELLLEKGAEVNALDGYN-RTALHYAAEKDEA-CVEVLLEYGANPNAL 114
L A +CVE L+ GA + D RT LH + C+ +LLE NP A+
Sbjct: 579 LDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAV 638
Query: 115 D---GNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILL 171
D TPL A + + V LLE A+V+ +D T L M G+ E V +LL
Sbjct: 639 DVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLL 698
Query: 172 DYGAEVRVINLIGQTPISRLVALLVRGLGT----------EKEDSCFE 209
+ + + G+TP+ A RG T +ED CF+
Sbjct: 699 EQEVSILCKDSRGRTPLHYAAA---RGHATWLSELLQMALSEEDCCFK 743
Score = 58.9 bits (141), Expect = 5e-09
Identities = 44/130 (33%), Positives = 64/130 (49%), Gaps = 4/130 (3%)
Query: 56 PLHCACMVSDADCVELLLEK--GAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPN 112
PLHCA + +C LLL + V+ D RT L AA D C+++LL + A N
Sbjct: 782 PLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVN 841
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESG-ASVNALDYNNDTPLSWAAMKGNLESVSILL 171
A+D + T L AA A V L+ S A + D + +TPL A KG+ + ++L
Sbjct: 842 AVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
Query: 172 DYGAEVRVIN 181
D + +IN
Sbjct: 902 DKIQDESLIN 911
Score = 55.5 bits (132), Expect = 5e-08
Identities = 47/141 (33%), Positives = 63/141 (44%), Gaps = 6/141 (4%)
Query: 37 VEDLIRGGADVNCTHGTLK--PLHCACMVSDADCVELLLE---KGAEVNALDGYNRTALH 91
VE LI GA + K PLH + + C+ LLLE V+ D +T L
Sbjct: 591 VEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLM 650
Query: 92 YAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYN 150
A V +LLE AN + +D T LH + ECV+ LLE S+ D
Sbjct: 651 LAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSR 710
Query: 151 NDTPLSWAAMKGNLESVSILL 171
TPL +AA +G+ +S LL
Sbjct: 711 GRTPLHYAAARGHATWLSELL 731
Score = 36.2 bits (82), Expect = 0.034
Identities = 21/57 (36%), Positives = 29/57 (50%)
Query: 137 LLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVA 193
L+ VN LD TPL AA G+ E + +L+ GA V + + TP+ R VA
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVA 58
>gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [Homo
sapiens]
Length = 278
Score = 90.5 bits (223), Expect = 2e-18
Identities = 82/254 (32%), Positives = 120/254 (47%), Gaps = 19/254 (7%)
Query: 37 VEDLIRGGADVN-CTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYA-A 94
++ LI GA VN T ++ PLH A + A CV+LLL GA+V+A + T L A A
Sbjct: 35 LQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACA 94
Query: 95 EKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTP 154
CV++LL YGA N +PLH A ++ECVR L++ GA++ A D + TP
Sbjct: 95 SGSIECVKLLLSYGAKVNP-PLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTP 153
Query: 155 LSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVALLVRGLGTEKEDSCFELLHRA 214
L A + +L+ V +LL+ GA V ++L + K E+L
Sbjct: 154 LHVACAREHLDCVKVLLNAGANVNA---------AKLHETALHHAAKVKNVDLIEMLIEF 204
Query: 215 VGHFELRKN-GTMPREV---ARDPQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDA 270
G+ R N G P + + P C P TL L R +R++ G++ L
Sbjct: 205 GGNIYARDNRGKKPSDYTWSSSAPAKC--FEYYEKTPLTLSQLCRVNLRKATGVRGLEKI 262
Query: 271 VKGLPLPASLKEYL 284
K L +P L +YL
Sbjct: 263 AK-LNIPPRLIDYL 275
Score = 68.9 bits (167), Expect = 5e-12
Identities = 38/92 (41%), Positives = 58/92 (63%), Gaps = 1/92 (1%)
Query: 87 RTALHYAAEKDEAC-VEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVN 145
RT +H AA++ E+ ++ L+E GA N + + TPLH A+ + A CV+ LL +GA V+
Sbjct: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
Query: 146 ALDYNNDTPLSWAAMKGNLESVSILLDYGAEV 177
A + + TPL A G++E V +LL YGA+V
Sbjct: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKV 111
Score = 51.6 bits (122), Expect = 8e-07
Identities = 27/69 (39%), Positives = 43/69 (62%)
Query: 120 TPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRV 179
TP+H AA + + ++ L+ESGA VN + ++ TPL A+++G V +LL GA+V
Sbjct: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
Query: 180 INLIGQTPI 188
N+ G TP+
Sbjct: 81 RNIDGSTPL 89
Score = 34.3 bits (77), Expect = 0.13
Identities = 19/58 (32%), Positives = 28/58 (48%)
Query: 35 DNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHY 92
D V+ L+ GA+VN LH A V + D +E+L+E G + A D + Y
Sbjct: 164 DCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDY 221
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 89.7 bits (221), Expect = 3e-18
Identities = 57/134 (42%), Positives = 74/134 (55%), Gaps = 3/134 (2%)
Query: 57 LHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAE--KDEACVEVLLEYGANPNAL 114
LH AC + VE LL+ G VN D + LH AA +DE V+ LL GA NA+
Sbjct: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEI-VKALLGKGAQVNAV 102
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ N TPLH+AA KN E LLE GA+ +A D+ T + AA KGNL+ + ILL Y
Sbjct: 103 NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK 162
Query: 175 AEVRVINLIGQTPI 188
A + + G TP+
Sbjct: 163 ASTNIQDTEGNTPL 176
Score = 87.8 bits (216), Expect = 1e-17
Identities = 59/154 (38%), Positives = 81/154 (52%), Gaps = 2/154 (1%)
Query: 37 VEDLIRGGADVNCTHGT-LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAE 95
VE L++ G VN PLH A + V+ LL KGA+VNA++ T LHYAA
Sbjct: 56 VEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAAS 115
Query: 96 KDEACVEV-LLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTP 154
K+ + V LLE GANP+A D T +H AA K N + + LL AS N D +TP
Sbjct: 116 KNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTP 175
Query: 155 LSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
L A + +E +L+ GA + + N +TP+
Sbjct: 176 LHLACDEERVEEAKLLVSQGASIYIENKEEKTPL 209
Score = 65.5 bits (158), Expect = 5e-11
Identities = 47/130 (36%), Positives = 64/130 (49%), Gaps = 4/130 (3%)
Query: 37 VEDLIRGGADVNCTHGT-LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAE 95
V+ L+ GA VN + PLH A + + +LLE GA +A D Y TA+H AA
Sbjct: 89 VKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
Query: 96 KDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTP 154
K + +LL Y A+ N D +TPLH A + E + L+ GAS+ + TP
Sbjct: 149 KGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTP 208
Query: 155 LSWAAMKGNL 164
L A KG L
Sbjct: 209 LQVA--KGGL 216
Score = 49.7 bits (117), Expect = 3e-06
Identities = 30/74 (40%), Positives = 37/74 (50%)
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
D + T LHWA + E V LL+ G VN D +PL AA G E V LL G
Sbjct: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
Query: 175 AEVRVINLIGQTPI 188
A+V +N G TP+
Sbjct: 97 AQVNAVNQNGCTPL 110
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 86.7 bits (213), Expect = 2e-17
Identities = 59/153 (38%), Positives = 83/153 (54%), Gaps = 2/153 (1%)
Query: 38 EDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEK 96
E L+ GA + T L P+H A DCV LLL+ AE++ + + T LH AA
Sbjct: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 381
Query: 97 DEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPL 155
V +VLL+ GA PN+ N TPLH A KN+ + LL++GAS++A+ + TPL
Sbjct: 382 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 441
Query: 156 SWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
A+ G+L V LL GA V N+ +TP+
Sbjct: 442 HVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 474
Score = 80.1 bits (196), Expect = 2e-15
Identities = 49/134 (36%), Positives = 72/134 (53%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNAL 114
PLH AC + +ELLL+ GA ++A+ T LH A+ V+ LL+ GA+PN
Sbjct: 407 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 466
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ +TPLH AA + E + LL++ A VNA ++ TPL AA G+ V +LL+
Sbjct: 467 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 526
Query: 175 AEVRVINLIGQTPI 188
A + G TP+
Sbjct: 527 ANPNLATTAGHTPL 540
Score = 79.7 bits (195), Expect = 3e-15
Identities = 61/179 (34%), Positives = 90/179 (50%), Gaps = 8/179 (4%)
Query: 26 IAAIRSFPHDNVEDLIRGGADVN-CTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDG 84
+ A RS D D +R G D+N C L LH A V LL K +
Sbjct: 50 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 109
Query: 85 YNRTALHYAA--EKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGA 142
TALH AA +DE V L+ YGAN NA TPL+ AA +N+ E V+ LLE+GA
Sbjct: 110 KGNTALHIAALAGQDEV-VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 168
Query: 143 SVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRV----INLIGQTPISRLVALLVR 197
+ N + TPL+ A +G+ V+ L++YG + +V +++ + +R A+L++
Sbjct: 169 NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 227
Score = 79.3 bits (194), Expect = 4e-15
Identities = 52/134 (38%), Positives = 68/134 (50%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNAL 114
PLH A ELLLE+ A NA T LH A + V++LL G +P++
Sbjct: 572 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 631
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
N TPLH AA +N E R+LL+ G S NA TPL AA +G+ E V++LL
Sbjct: 632 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 691
Query: 175 AEVRVINLIGQTPI 188
A + N G TP+
Sbjct: 692 ANGNLGNKSGLTPL 705
Score = 78.6 bits (192), Expect = 6e-15
Identities = 64/197 (32%), Positives = 96/197 (48%), Gaps = 17/197 (8%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACV-EVLLEYGANPN 112
L PLH A ++ D V+LLL +G ++ T LH AA++++ V LL+YG + N
Sbjct: 603 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 662
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLD 172
A TPLH AA + +AE V LL A+ N + + TPL A +G++ +L+
Sbjct: 663 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 722
Query: 173 YGAEVRVINLIGQTPIS--------RLVALLVRGLG--TEKEDSCFELLHRAV--GHFE- 219
+G V +G TP+ +LV L++ K + LH+A GH +
Sbjct: 723 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 782
Query: 220 ---LRKNGTMPREVARD 233
L KNG P EV+ D
Sbjct: 783 VTLLLKNGASPNEVSSD 799
Score = 77.8 bits (190), Expect = 1e-14
Identities = 50/150 (33%), Positives = 72/150 (48%), Gaps = 1/150 (0%)
Query: 40 LIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA 99
L RG T L PLHCA E+LL+ GA + A + +H AA+ D
Sbjct: 292 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHL 351
Query: 100 -CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWA 158
CV +LL+Y A + + + TPLH AA + + LL+ GA N+ N TPL A
Sbjct: 352 DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA 411
Query: 159 AMKGNLESVSILLDYGAEVRVINLIGQTPI 188
K ++ + +LL GA + + G TP+
Sbjct: 412 CKKNHVRVMELLLKTGASIDAVTESGLTPL 441
Score = 77.8 bits (190), Expect = 1e-14
Identities = 59/183 (32%), Positives = 79/183 (43%), Gaps = 42/183 (22%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA--------------EKDEACV 101
PLHCA + + V+LLLE A N T LH AA E +AC+
Sbjct: 506 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 565
Query: 102 --------------------EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESG 141
E+LLE A+PNA N TPLH A NN + V+ LL G
Sbjct: 566 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 625
Query: 142 ASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI--------SRLVA 193
S ++ +N TPL AA + +E LL YG ++ G TP+ + +VA
Sbjct: 626 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 685
Query: 194 LLV 196
LL+
Sbjct: 686 LLL 688
Score = 73.6 bits (179), Expect = 2e-13
Identities = 59/183 (32%), Positives = 79/183 (43%), Gaps = 31/183 (16%)
Query: 37 VEDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNAL--DGYNRTA---- 89
V +L+ GA+VN + PL+ A + + V+ LLE GA N DG+ A
Sbjct: 127 VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQ 186
Query: 90 -----------------------LHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWA 125
LH AA D+ VLL+ NP+ L TPLH A
Sbjct: 187 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 246
Query: 126 AFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQ 185
A N + LL GASVN N TPL A+ +GN+ V +LLD GA++
Sbjct: 247 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 306
Query: 186 TPI 188
TP+
Sbjct: 307 TPL 309
Score = 70.5 bits (171), Expect = 2e-12
Identities = 53/154 (34%), Positives = 77/154 (50%), Gaps = 2/154 (1%)
Query: 37 VEDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAE 95
+E L++ GA ++ T L PLH A + V+ LL++GA N + T LH AA
Sbjct: 420 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR 479
Query: 96 KDEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTP 154
V + LL+ A NA + TPLH AA + V+ LLE+ A+ N TP
Sbjct: 480 AGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 539
Query: 155 LSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
L AA +G++E+V LL+ A + G TP+
Sbjct: 540 LHIAAREGHVETVLALLEKEASQACMTKKGFTPL 573
Score = 70.5 bits (171), Expect = 2e-12
Identities = 50/148 (33%), Positives = 75/148 (50%), Gaps = 2/148 (1%)
Query: 43 GGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACV- 101
G A+ G + PLH A A+ V LLL K A N + T LH A++ V
Sbjct: 659 GSANAESVQG-VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 717
Query: 102 EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMK 161
+VL+++G +A TPLH A+ N + V+ LL+ A VNA +PL AA +
Sbjct: 718 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 777
Query: 162 GNLESVSILLDYGAEVRVINLIGQTPIS 189
G+ + V++LL GA ++ G TP++
Sbjct: 778 GHTDIVTLLLKNGASPNEVSSDGTTPLA 805
Score = 70.1 bits (170), Expect = 2e-12
Identities = 46/134 (34%), Positives = 65/134 (48%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEAC-VEVLLEYGANPNAL 114
PLH A + + +LLL +GA VN T LH A+ + V +LL+ GA
Sbjct: 242 PLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 301
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ TPLH AA + LL+ GA + A N +P+ AA +L+ V +LL Y
Sbjct: 302 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 361
Query: 175 AEVRVINLIGQTPI 188
AE+ I L TP+
Sbjct: 362 AEIDDITLDHLTPL 375
Score = 67.8 bits (164), Expect = 1e-11
Identities = 47/136 (34%), Positives = 65/136 (47%), Gaps = 1/136 (0%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACV-EVLLEYGANPN 112
L LH A D +LL+ + L T LH AA + V ++LL GA+ N
Sbjct: 207 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 266
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLD 172
N TPLH A+ + N VR LL+ GA + + TPL AA G++ ILLD
Sbjct: 267 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 326
Query: 173 YGAEVRVINLIGQTPI 188
+GA ++ G +PI
Sbjct: 327 HGAPIQAKTKNGLSPI 342
Score = 53.5 bits (127), Expect = 2e-07
Identities = 36/118 (30%), Positives = 57/118 (48%), Gaps = 1/118 (0%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPN 112
L PLH ++L++ G V+A T LH A+ V+ LL++ A+ N
Sbjct: 702 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 761
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSIL 170
A +PLH AA + + + V LL++GAS N + + TPL+ A G + +L
Sbjct: 762 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 86.7 bits (213), Expect = 2e-17
Identities = 59/153 (38%), Positives = 83/153 (54%), Gaps = 2/153 (1%)
Query: 38 EDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEK 96
E L+ GA + T L P+H A DCV LLL+ AE++ + + T LH AA
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
Query: 97 DEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPL 155
V +VLL+ GA PN+ N TPLH A KN+ + LL++GAS++A+ + TPL
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 156 SWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
A+ G+L V LL GA V N+ +TP+
Sbjct: 409 HVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Score = 80.1 bits (196), Expect = 2e-15
Identities = 49/134 (36%), Positives = 72/134 (53%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNAL 114
PLH AC + +ELLL+ GA ++A+ T LH A+ V+ LL+ GA+PN
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ +TPLH AA + E + LL++ A VNA ++ TPL AA G+ V +LL+
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 493
Query: 175 AEVRVINLIGQTPI 188
A + G TP+
Sbjct: 494 ANPNLATTAGHTPL 507
Score = 79.7 bits (195), Expect = 3e-15
Identities = 61/179 (34%), Positives = 90/179 (50%), Gaps = 8/179 (4%)
Query: 26 IAAIRSFPHDNVEDLIRGGADVN-CTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDG 84
+ A RS D D +R G D+N C L LH A V LL K +
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 85 YNRTALHYAA--EKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGA 142
TALH AA +DE V L+ YGAN NA TPL+ AA +N+ E V+ LLE+GA
Sbjct: 77 KGNTALHIAALAGQDEV-VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 143 SVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRV----INLIGQTPISRLVALLVR 197
+ N + TPL+ A +G+ V+ L++YG + +V +++ + +R A+L++
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Score = 79.3 bits (194), Expect = 4e-15
Identities = 52/134 (38%), Positives = 68/134 (50%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNAL 114
PLH A ELLLE+ A NA T LH A + V++LL G +P++
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
N TPLH AA +N E R+LL+ G S NA TPL AA +G+ E V++LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 175 AEVRVINLIGQTPI 188
A + N G TP+
Sbjct: 659 ANGNLGNKSGLTPL 672
Score = 78.6 bits (192), Expect = 6e-15
Identities = 64/197 (32%), Positives = 96/197 (48%), Gaps = 17/197 (8%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACV-EVLLEYGANPN 112
L PLH A ++ D V+LLL +G ++ T LH AA++++ V LL+YG + N
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLD 172
A TPLH AA + +AE V LL A+ N + + TPL A +G++ +L+
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Query: 173 YGAEVRVINLIGQTPIS--------RLVALLVRGLG--TEKEDSCFELLHRAV--GHFE- 219
+G V +G TP+ +LV L++ K + LH+A GH +
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 220 ---LRKNGTMPREVARD 233
L KNG P EV+ D
Sbjct: 750 VTLLLKNGASPNEVSSD 766
Score = 77.8 bits (190), Expect = 1e-14
Identities = 50/150 (33%), Positives = 72/150 (48%), Gaps = 1/150 (0%)
Query: 40 LIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA 99
L RG T L PLHCA E+LL+ GA + A + +H AA+ D
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHL 318
Query: 100 -CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWA 158
CV +LL+Y A + + + TPLH AA + + LL+ GA N+ N TPL A
Sbjct: 319 DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA 378
Query: 159 AMKGNLESVSILLDYGAEVRVINLIGQTPI 188
K ++ + +LL GA + + G TP+
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Score = 77.8 bits (190), Expect = 1e-14
Identities = 59/183 (32%), Positives = 79/183 (43%), Gaps = 42/183 (22%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA--------------EKDEACV 101
PLHCA + + V+LLLE A N T LH AA E +AC+
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 102 --------------------EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESG 141
E+LLE A+PNA N TPLH A NN + V+ LL G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 142 ASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI--------SRLVA 193
S ++ +N TPL AA + +E LL YG ++ G TP+ + +VA
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Query: 194 LLV 196
LL+
Sbjct: 653 LLL 655
Score = 73.6 bits (179), Expect = 2e-13
Identities = 59/183 (32%), Positives = 79/183 (43%), Gaps = 31/183 (16%)
Query: 37 VEDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNAL--DGYNRTA---- 89
V +L+ GA+VN + PL+ A + + V+ LLE GA N DG+ A
Sbjct: 94 VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQ 153
Query: 90 -----------------------LHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWA 125
LH AA D+ VLL+ NP+ L TPLH A
Sbjct: 154 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Query: 126 AFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQ 185
A N + LL GASVN N TPL A+ +GN+ V +LLD GA++
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273
Query: 186 TPI 188
TP+
Sbjct: 274 TPL 276
Score = 70.5 bits (171), Expect = 2e-12
Identities = 53/154 (34%), Positives = 77/154 (50%), Gaps = 2/154 (1%)
Query: 37 VEDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAE 95
+E L++ GA ++ T L PLH A + V+ LL++GA N + T LH AA
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR 446
Query: 96 KDEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTP 154
V + LL+ A NA + TPLH AA + V+ LLE+ A+ N TP
Sbjct: 447 AGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
Query: 155 LSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
L AA +G++E+V LL+ A + G TP+
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Score = 70.5 bits (171), Expect = 2e-12
Identities = 50/148 (33%), Positives = 75/148 (50%), Gaps = 2/148 (1%)
Query: 43 GGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACV- 101
G A+ G + PLH A A+ V LLL K A N + T LH A++ V
Sbjct: 626 GSANAESVQG-VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 102 EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMK 161
+VL+++G +A TPLH A+ N + V+ LL+ A VNA +PL AA +
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
Query: 162 GNLESVSILLDYGAEVRVINLIGQTPIS 189
G+ + V++LL GA ++ G TP++
Sbjct: 745 GHTDIVTLLLKNGASPNEVSSDGTTPLA 772
Score = 70.1 bits (170), Expect = 2e-12
Identities = 46/134 (34%), Positives = 65/134 (48%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEAC-VEVLLEYGANPNAL 114
PLH A + + +LLL +GA VN T LH A+ + V +LL+ GA
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ TPLH AA + LL+ GA + A N +P+ AA +L+ V +LL Y
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 175 AEVRVINLIGQTPI 188
AE+ I L TP+
Sbjct: 329 AEIDDITLDHLTPL 342
Score = 67.8 bits (164), Expect = 1e-11
Identities = 47/136 (34%), Positives = 65/136 (47%), Gaps = 1/136 (0%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACV-EVLLEYGANPN 112
L LH A D +LL+ + L T LH AA + V ++LL GA+ N
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLD 172
N TPLH A+ + N VR LL+ GA + + TPL AA G++ ILLD
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 173 YGAEVRVINLIGQTPI 188
+GA ++ G +PI
Sbjct: 294 HGAPIQAKTKNGLSPI 309
Score = 53.5 bits (127), Expect = 2e-07
Identities = 36/118 (30%), Positives = 57/118 (48%), Gaps = 1/118 (0%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPN 112
L PLH ++L++ G V+A T LH A+ V+ LL++ A+ N
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSIL 170
A +PLH AA + + + V LL++GAS N + + TPL+ A G + +L
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 86.7 bits (213), Expect = 2e-17
Identities = 59/153 (38%), Positives = 83/153 (54%), Gaps = 2/153 (1%)
Query: 38 EDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEK 96
E L+ GA + T L P+H A DCV LLL+ AE++ + + T LH AA
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
Query: 97 DEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPL 155
V +VLL+ GA PN+ N TPLH A KN+ + LL++GAS++A+ + TPL
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 156 SWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
A+ G+L V LL GA V N+ +TP+
Sbjct: 409 HVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Score = 80.1 bits (196), Expect = 2e-15
Identities = 49/134 (36%), Positives = 72/134 (53%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNAL 114
PLH AC + +ELLL+ GA ++A+ T LH A+ V+ LL+ GA+PN
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ +TPLH AA + E + LL++ A VNA ++ TPL AA G+ V +LL+
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 493
Query: 175 AEVRVINLIGQTPI 188
A + G TP+
Sbjct: 494 ANPNLATTAGHTPL 507
Score = 79.7 bits (195), Expect = 3e-15
Identities = 61/179 (34%), Positives = 90/179 (50%), Gaps = 8/179 (4%)
Query: 26 IAAIRSFPHDNVEDLIRGGADVN-CTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDG 84
+ A RS D D +R G D+N C L LH A V LL K +
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 85 YNRTALHYAA--EKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGA 142
TALH AA +DE V L+ YGAN NA TPL+ AA +N+ E V+ LLE+GA
Sbjct: 77 KGNTALHIAALAGQDEV-VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 143 SVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRV----INLIGQTPISRLVALLVR 197
+ N + TPL+ A +G+ V+ L++YG + +V +++ + +R A+L++
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Score = 79.3 bits (194), Expect = 4e-15
Identities = 52/134 (38%), Positives = 68/134 (50%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNAL 114
PLH A ELLLE+ A NA T LH A + V++LL G +P++
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
N TPLH AA +N E R+LL+ G S NA TPL AA +G+ E V++LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 175 AEVRVINLIGQTPI 188
A + N G TP+
Sbjct: 659 ANGNLGNKSGLTPL 672
Score = 78.6 bits (192), Expect = 6e-15
Identities = 64/197 (32%), Positives = 96/197 (48%), Gaps = 17/197 (8%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACV-EVLLEYGANPN 112
L PLH A ++ D V+LLL +G ++ T LH AA++++ V LL+YG + N
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLD 172
A TPLH AA + +AE V LL A+ N + + TPL A +G++ +L+
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Query: 173 YGAEVRVINLIGQTPIS--------RLVALLVRGLG--TEKEDSCFELLHRAV--GHFE- 219
+G V +G TP+ +LV L++ K + LH+A GH +
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 220 ---LRKNGTMPREVARD 233
L KNG P EV+ D
Sbjct: 750 VTLLLKNGASPNEVSSD 766
Score = 77.8 bits (190), Expect = 1e-14
Identities = 50/150 (33%), Positives = 72/150 (48%), Gaps = 1/150 (0%)
Query: 40 LIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA 99
L RG T L PLHCA E+LL+ GA + A + +H AA+ D
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHL 318
Query: 100 -CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWA 158
CV +LL+Y A + + + TPLH AA + + LL+ GA N+ N TPL A
Sbjct: 319 DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA 378
Query: 159 AMKGNLESVSILLDYGAEVRVINLIGQTPI 188
K ++ + +LL GA + + G TP+
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Score = 77.8 bits (190), Expect = 1e-14
Identities = 59/183 (32%), Positives = 79/183 (43%), Gaps = 42/183 (22%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA--------------EKDEACV 101
PLHCA + + V+LLLE A N T LH AA E +AC+
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 102 --------------------EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESG 141
E+LLE A+PNA N TPLH A NN + V+ LL G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 142 ASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI--------SRLVA 193
S ++ +N TPL AA + +E LL YG ++ G TP+ + +VA
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Query: 194 LLV 196
LL+
Sbjct: 653 LLL 655
Score = 73.6 bits (179), Expect = 2e-13
Identities = 59/183 (32%), Positives = 79/183 (43%), Gaps = 31/183 (16%)
Query: 37 VEDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNAL--DGYNRTA---- 89
V +L+ GA+VN + PL+ A + + V+ LLE GA N DG+ A
Sbjct: 94 VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQ 153
Query: 90 -----------------------LHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWA 125
LH AA D+ VLL+ NP+ L TPLH A
Sbjct: 154 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Query: 126 AFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQ 185
A N + LL GASVN N TPL A+ +GN+ V +LLD GA++
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273
Query: 186 TPI 188
TP+
Sbjct: 274 TPL 276
Score = 70.5 bits (171), Expect = 2e-12
Identities = 53/154 (34%), Positives = 77/154 (50%), Gaps = 2/154 (1%)
Query: 37 VEDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAE 95
+E L++ GA ++ T L PLH A + V+ LL++GA N + T LH AA
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR 446
Query: 96 KDEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTP 154
V + LL+ A NA + TPLH AA + V+ LLE+ A+ N TP
Sbjct: 447 AGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
Query: 155 LSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
L AA +G++E+V LL+ A + G TP+
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Score = 70.5 bits (171), Expect = 2e-12
Identities = 50/148 (33%), Positives = 75/148 (50%), Gaps = 2/148 (1%)
Query: 43 GGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACV- 101
G A+ G + PLH A A+ V LLL K A N + T LH A++ V
Sbjct: 626 GSANAESVQG-VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 102 EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMK 161
+VL+++G +A TPLH A+ N + V+ LL+ A VNA +PL AA +
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
Query: 162 GNLESVSILLDYGAEVRVINLIGQTPIS 189
G+ + V++LL GA ++ G TP++
Sbjct: 745 GHTDIVTLLLKNGASPNEVSSDGTTPLA 772
Score = 70.1 bits (170), Expect = 2e-12
Identities = 46/134 (34%), Positives = 65/134 (48%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEAC-VEVLLEYGANPNAL 114
PLH A + + +LLL +GA VN T LH A+ + V +LL+ GA
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ TPLH AA + LL+ GA + A N +P+ AA +L+ V +LL Y
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 175 AEVRVINLIGQTPI 188
AE+ I L TP+
Sbjct: 329 AEIDDITLDHLTPL 342
Score = 67.8 bits (164), Expect = 1e-11
Identities = 47/136 (34%), Positives = 65/136 (47%), Gaps = 1/136 (0%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACV-EVLLEYGANPN 112
L LH A D +LL+ + L T LH AA + V ++LL GA+ N
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLD 172
N TPLH A+ + N VR LL+ GA + + TPL AA G++ ILLD
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 173 YGAEVRVINLIGQTPI 188
+GA ++ G +PI
Sbjct: 294 HGAPIQAKTKNGLSPI 309
Score = 53.5 bits (127), Expect = 2e-07
Identities = 36/118 (30%), Positives = 57/118 (48%), Gaps = 1/118 (0%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPN 112
L PLH ++L++ G V+A T LH A+ V+ LL++ A+ N
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSIL 170
A +PLH AA + + + V LL++GAS N + + TPL+ A G + +L
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 86.7 bits (213), Expect = 2e-17
Identities = 59/153 (38%), Positives = 83/153 (54%), Gaps = 2/153 (1%)
Query: 38 EDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEK 96
E L+ GA + T L P+H A DCV LLL+ AE++ + + T LH AA
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
Query: 97 DEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPL 155
V +VLL+ GA PN+ N TPLH A KN+ + LL++GAS++A+ + TPL
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 156 SWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
A+ G+L V LL GA V N+ +TP+
Sbjct: 409 HVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Score = 80.1 bits (196), Expect = 2e-15
Identities = 49/134 (36%), Positives = 72/134 (53%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNAL 114
PLH AC + +ELLL+ GA ++A+ T LH A+ V+ LL+ GA+PN
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ +TPLH AA + E + LL++ A VNA ++ TPL AA G+ V +LL+
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 493
Query: 175 AEVRVINLIGQTPI 188
A + G TP+
Sbjct: 494 ANPNLATTAGHTPL 507
Score = 79.7 bits (195), Expect = 3e-15
Identities = 61/179 (34%), Positives = 90/179 (50%), Gaps = 8/179 (4%)
Query: 26 IAAIRSFPHDNVEDLIRGGADVN-CTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDG 84
+ A RS D D +R G D+N C L LH A V LL K +
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 85 YNRTALHYAA--EKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGA 142
TALH AA +DE V L+ YGAN NA TPL+ AA +N+ E V+ LLE+GA
Sbjct: 77 KGNTALHIAALAGQDEV-VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 143 SVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRV----INLIGQTPISRLVALLVR 197
+ N + TPL+ A +G+ V+ L++YG + +V +++ + +R A+L++
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Score = 79.3 bits (194), Expect = 4e-15
Identities = 52/134 (38%), Positives = 68/134 (50%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNAL 114
PLH A ELLLE+ A NA T LH A + V++LL G +P++
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
N TPLH AA +N E R+LL+ G S NA TPL AA +G+ E V++LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 175 AEVRVINLIGQTPI 188
A + N G TP+
Sbjct: 659 ANGNLGNKSGLTPL 672
Score = 78.6 bits (192), Expect = 6e-15
Identities = 64/197 (32%), Positives = 96/197 (48%), Gaps = 17/197 (8%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACV-EVLLEYGANPN 112
L PLH A ++ D V+LLL +G ++ T LH AA++++ V LL+YG + N
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLD 172
A TPLH AA + +AE V LL A+ N + + TPL A +G++ +L+
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Query: 173 YGAEVRVINLIGQTPIS--------RLVALLVRGLG--TEKEDSCFELLHRAV--GHFE- 219
+G V +G TP+ +LV L++ K + LH+A GH +
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 220 ---LRKNGTMPREVARD 233
L KNG P EV+ D
Sbjct: 750 VTLLLKNGASPNEVSSD 766
Score = 77.8 bits (190), Expect = 1e-14
Identities = 50/150 (33%), Positives = 72/150 (48%), Gaps = 1/150 (0%)
Query: 40 LIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA 99
L RG T L PLHCA E+LL+ GA + A + +H AA+ D
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHL 318
Query: 100 -CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWA 158
CV +LL+Y A + + + TPLH AA + + LL+ GA N+ N TPL A
Sbjct: 319 DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA 378
Query: 159 AMKGNLESVSILLDYGAEVRVINLIGQTPI 188
K ++ + +LL GA + + G TP+
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Score = 77.8 bits (190), Expect = 1e-14
Identities = 59/183 (32%), Positives = 79/183 (43%), Gaps = 42/183 (22%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA--------------EKDEACV 101
PLHCA + + V+LLLE A N T LH AA E +AC+
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 102 --------------------EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESG 141
E+LLE A+PNA N TPLH A NN + V+ LL G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 142 ASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI--------SRLVA 193
S ++ +N TPL AA + +E LL YG ++ G TP+ + +VA
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Query: 194 LLV 196
LL+
Sbjct: 653 LLL 655
Score = 73.6 bits (179), Expect = 2e-13
Identities = 59/183 (32%), Positives = 79/183 (43%), Gaps = 31/183 (16%)
Query: 37 VEDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNAL--DGYNRTA---- 89
V +L+ GA+VN + PL+ A + + V+ LLE GA N DG+ A
Sbjct: 94 VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQ 153
Query: 90 -----------------------LHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWA 125
LH AA D+ VLL+ NP+ L TPLH A
Sbjct: 154 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Query: 126 AFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQ 185
A N + LL GASVN N TPL A+ +GN+ V +LLD GA++
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273
Query: 186 TPI 188
TP+
Sbjct: 274 TPL 276
Score = 70.5 bits (171), Expect = 2e-12
Identities = 53/154 (34%), Positives = 77/154 (50%), Gaps = 2/154 (1%)
Query: 37 VEDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAE 95
+E L++ GA ++ T L PLH A + V+ LL++GA N + T LH AA
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR 446
Query: 96 KDEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTP 154
V + LL+ A NA + TPLH AA + V+ LLE+ A+ N TP
Sbjct: 447 AGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
Query: 155 LSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
L AA +G++E+V LL+ A + G TP+
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Score = 70.5 bits (171), Expect = 2e-12
Identities = 50/148 (33%), Positives = 75/148 (50%), Gaps = 2/148 (1%)
Query: 43 GGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACV- 101
G A+ G + PLH A A+ V LLL K A N + T LH A++ V
Sbjct: 626 GSANAESVQG-VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 102 EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMK 161
+VL+++G +A TPLH A+ N + V+ LL+ A VNA +PL AA +
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
Query: 162 GNLESVSILLDYGAEVRVINLIGQTPIS 189
G+ + V++LL GA ++ G TP++
Sbjct: 745 GHTDIVTLLLKNGASPNEVSSDGTTPLA 772
Score = 70.1 bits (170), Expect = 2e-12
Identities = 46/134 (34%), Positives = 65/134 (48%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEAC-VEVLLEYGANPNAL 114
PLH A + + +LLL +GA VN T LH A+ + V +LL+ GA
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ TPLH AA + LL+ GA + A N +P+ AA +L+ V +LL Y
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 175 AEVRVINLIGQTPI 188
AE+ I L TP+
Sbjct: 329 AEIDDITLDHLTPL 342
Score = 67.8 bits (164), Expect = 1e-11
Identities = 47/136 (34%), Positives = 65/136 (47%), Gaps = 1/136 (0%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACV-EVLLEYGANPN 112
L LH A D +LL+ + L T LH AA + V ++LL GA+ N
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLD 172
N TPLH A+ + N VR LL+ GA + + TPL AA G++ ILLD
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 173 YGAEVRVINLIGQTPI 188
+GA ++ G +PI
Sbjct: 294 HGAPIQAKTKNGLSPI 309
Score = 53.5 bits (127), Expect = 2e-07
Identities = 36/118 (30%), Positives = 57/118 (48%), Gaps = 1/118 (0%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPN 112
L PLH ++L++ G V+A T LH A+ V+ LL++ A+ N
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSIL 170
A +PLH AA + + + V LL++GAS N + + TPL+ A G + +L
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 86.7 bits (213), Expect = 2e-17
Identities = 59/153 (38%), Positives = 83/153 (54%), Gaps = 2/153 (1%)
Query: 38 EDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEK 96
E L+ GA + T L P+H A DCV LLL+ AE++ + + T LH AA
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
Query: 97 DEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPL 155
V +VLL+ GA PN+ N TPLH A KN+ + LL++GAS++A+ + TPL
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 156 SWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
A+ G+L V LL GA V N+ +TP+
Sbjct: 409 HVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Score = 80.1 bits (196), Expect = 2e-15
Identities = 49/134 (36%), Positives = 72/134 (53%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNAL 114
PLH AC + +ELLL+ GA ++A+ T LH A+ V+ LL+ GA+PN
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ +TPLH AA + E + LL++ A VNA ++ TPL AA G+ V +LL+
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 493
Query: 175 AEVRVINLIGQTPI 188
A + G TP+
Sbjct: 494 ANPNLATTAGHTPL 507
Score = 79.7 bits (195), Expect = 3e-15
Identities = 61/179 (34%), Positives = 90/179 (50%), Gaps = 8/179 (4%)
Query: 26 IAAIRSFPHDNVEDLIRGGADVN-CTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDG 84
+ A RS D D +R G D+N C L LH A V LL K +
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 85 YNRTALHYAA--EKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGA 142
TALH AA +DE V L+ YGAN NA TPL+ AA +N+ E V+ LLE+GA
Sbjct: 77 KGNTALHIAALAGQDEV-VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 143 SVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRV----INLIGQTPISRLVALLVR 197
+ N + TPL+ A +G+ V+ L++YG + +V +++ + +R A+L++
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Score = 79.3 bits (194), Expect = 4e-15
Identities = 52/134 (38%), Positives = 68/134 (50%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNAL 114
PLH A ELLLE+ A NA T LH A + V++LL G +P++
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
N TPLH AA +N E R+LL+ G S NA TPL AA +G+ E V++LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 175 AEVRVINLIGQTPI 188
A + N G TP+
Sbjct: 659 ANGNLGNKSGLTPL 672
Score = 78.6 bits (192), Expect = 6e-15
Identities = 64/197 (32%), Positives = 96/197 (48%), Gaps = 17/197 (8%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACV-EVLLEYGANPN 112
L PLH A ++ D V+LLL +G ++ T LH AA++++ V LL+YG + N
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLD 172
A TPLH AA + +AE V LL A+ N + + TPL A +G++ +L+
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Query: 173 YGAEVRVINLIGQTPIS--------RLVALLVRGLG--TEKEDSCFELLHRAV--GHFE- 219
+G V +G TP+ +LV L++ K + LH+A GH +
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Query: 220 ---LRKNGTMPREVARD 233
L KNG P EV+ D
Sbjct: 750 VTLLLKNGASPNEVSSD 766
Score = 77.8 bits (190), Expect = 1e-14
Identities = 50/150 (33%), Positives = 72/150 (48%), Gaps = 1/150 (0%)
Query: 40 LIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA 99
L RG T L PLHCA E+LL+ GA + A + +H AA+ D
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHL 318
Query: 100 -CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWA 158
CV +LL+Y A + + + TPLH AA + + LL+ GA N+ N TPL A
Sbjct: 319 DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA 378
Query: 159 AMKGNLESVSILLDYGAEVRVINLIGQTPI 188
K ++ + +LL GA + + G TP+
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Score = 77.8 bits (190), Expect = 1e-14
Identities = 59/183 (32%), Positives = 79/183 (43%), Gaps = 42/183 (22%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA--------------EKDEACV 101
PLHCA + + V+LLLE A N T LH AA E +AC+
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 102 --------------------EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESG 141
E+LLE A+PNA N TPLH A NN + V+ LL G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 142 ASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI--------SRLVA 193
S ++ +N TPL AA + +E LL YG ++ G TP+ + +VA
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Query: 194 LLV 196
LL+
Sbjct: 653 LLL 655
Score = 73.6 bits (179), Expect = 2e-13
Identities = 59/183 (32%), Positives = 79/183 (43%), Gaps = 31/183 (16%)
Query: 37 VEDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNAL--DGYNRTA---- 89
V +L+ GA+VN + PL+ A + + V+ LLE GA N DG+ A
Sbjct: 94 VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQ 153
Query: 90 -----------------------LHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWA 125
LH AA D+ VLL+ NP+ L TPLH A
Sbjct: 154 QGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Query: 126 AFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQ 185
A N + LL GASVN N TPL A+ +GN+ V +LLD GA++
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273
Query: 186 TPI 188
TP+
Sbjct: 274 TPL 276
Score = 70.5 bits (171), Expect = 2e-12
Identities = 53/154 (34%), Positives = 77/154 (50%), Gaps = 2/154 (1%)
Query: 37 VEDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAE 95
+E L++ GA ++ T L PLH A + V+ LL++GA N + T LH AA
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR 446
Query: 96 KDEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTP 154
V + LL+ A NA + TPLH AA + V+ LLE+ A+ N TP
Sbjct: 447 AGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
Query: 155 LSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
L AA +G++E+V LL+ A + G TP+
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Score = 70.5 bits (171), Expect = 2e-12
Identities = 50/148 (33%), Positives = 75/148 (50%), Gaps = 2/148 (1%)
Query: 43 GGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACV- 101
G A+ G + PLH A A+ V LLL K A N + T LH A++ V
Sbjct: 626 GSANAESVQG-VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 102 EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMK 161
+VL+++G +A TPLH A+ N + V+ LL+ A VNA +PL AA +
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
Query: 162 GNLESVSILLDYGAEVRVINLIGQTPIS 189
G+ + V++LL GA ++ G TP++
Sbjct: 745 GHTDIVTLLLKNGASPNEVSSDGTTPLA 772
Score = 70.1 bits (170), Expect = 2e-12
Identities = 46/134 (34%), Positives = 65/134 (48%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEAC-VEVLLEYGANPNAL 114
PLH A + + +LLL +GA VN T LH A+ + V +LL+ GA
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ TPLH AA + LL+ GA + A N +P+ AA +L+ V +LL Y
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 175 AEVRVINLIGQTPI 188
AE+ I L TP+
Sbjct: 329 AEIDDITLDHLTPL 342
Score = 67.8 bits (164), Expect = 1e-11
Identities = 47/136 (34%), Positives = 65/136 (47%), Gaps = 1/136 (0%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACV-EVLLEYGANPN 112
L LH A D +LL+ + L T LH AA + V ++LL GA+ N
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLD 172
N TPLH A+ + N VR LL+ GA + + TPL AA G++ ILLD
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 173 YGAEVRVINLIGQTPI 188
+GA ++ G +PI
Sbjct: 294 HGAPIQAKTKNGLSPI 309
Score = 53.5 bits (127), Expect = 2e-07
Identities = 36/118 (30%), Positives = 57/118 (48%), Gaps = 1/118 (0%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPN 112
L PLH ++L++ G V+A T LH A+ V+ LL++ A+ N
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSIL 170
A +PLH AA + + + V LL++GAS N + + TPL+ A G + +L
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 85.5 bits (210), Expect = 5e-17
Identities = 68/196 (34%), Positives = 96/196 (48%), Gaps = 20/196 (10%)
Query: 38 EDLIRGGADVNCTHGT-LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA-E 95
E L+ GA V+ T+ + PL CA V LLLE+G +VN D RT L AA E
Sbjct: 1088 ELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACE 1147
Query: 96 KDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPL 155
+ VE LL GA ++LD + L WA K + V+ L+E GA+++ D N TPL
Sbjct: 1148 GHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPL 1207
Query: 156 SWAAMKGNLESVSILLDYGAEVRVINLIGQTPISR---------LVALLVRG-------- 198
AA G+ E+V L++ GA + ++ G P+ R +VALL +G
Sbjct: 1208 DLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAW 1267
Query: 199 -LGTEKEDSCFELLHR 213
+ T K D LL +
Sbjct: 1268 AMATSKPDILIILLQK 1283
Score = 38.5 bits (88), Expect = 0.007
Identities = 60/232 (25%), Positives = 89/232 (38%), Gaps = 53/232 (22%)
Query: 9 MQSIQSKYSLSERLIRTIAAIRSFPHDNVED---LIRGGADVNCTHGTLKPLHCACMVSD 65
+Q++ YS +E L +A++R+ NV+ LI GGA+VN L C+ S
Sbjct: 878 LQALWIGYS-TEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSH 936
Query: 66 A---DCVELLLEKGAEVNALDGYNRTALHYAAEKDE-ACVEVLLEYGANPNALDGNRDTP 121
+ V LLLE GA ++ TAL YAA V +L + G + LD
Sbjct: 937 LGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCA 996
Query: 122 LHWAAFKNNAECVRALL------------------------------------------- 138
L +A + + + ++ LL
Sbjct: 997 LVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGME 1056
Query: 139 -ESGASVNALD-YNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
E VN D +T L+ AA +G LE +LL +GA V N G P+
Sbjct: 1057 KEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPL 1108
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 85.5 bits (210), Expect = 5e-17
Identities = 68/196 (34%), Positives = 96/196 (48%), Gaps = 20/196 (10%)
Query: 38 EDLIRGGADVNCTHGT-LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA-E 95
E L+ GA V+ T+ + PL CA V LLLE+G +VN D RT L AA E
Sbjct: 1096 ELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACE 1155
Query: 96 KDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPL 155
+ VE LL GA ++LD + L WA K + V+ L+E GA+++ D N TPL
Sbjct: 1156 GHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPL 1215
Query: 156 SWAAMKGNLESVSILLDYGAEVRVINLIGQTPISR---------LVALLVRG-------- 198
AA G+ E+V L++ GA + ++ G P+ R +VALL +G
Sbjct: 1216 DLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGNAAW 1275
Query: 199 -LGTEKEDSCFELLHR 213
+ T K D LL +
Sbjct: 1276 AMATSKPDILIILLQK 1291
Score = 38.5 bits (88), Expect = 0.007
Identities = 60/232 (25%), Positives = 89/232 (38%), Gaps = 53/232 (22%)
Query: 9 MQSIQSKYSLSERLIRTIAAIRSFPHDNVED---LIRGGADVNCTHGTLKPLHCACMVSD 65
+Q++ YS +E L +A++R+ NV+ LI GGA+VN L C+ S
Sbjct: 886 LQALWIGYS-TEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSH 944
Query: 66 A---DCVELLLEKGAEVNALDGYNRTALHYAAEKDE-ACVEVLLEYGANPNALDGNRDTP 121
+ V LLLE GA ++ TAL YAA V +L + G + LD
Sbjct: 945 LGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCA 1004
Query: 122 LHWAAFKNNAECVRALL------------------------------------------- 138
L +A + + + ++ LL
Sbjct: 1005 LVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGME 1064
Query: 139 -ESGASVNALD-YNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
E VN D +T L+ AA +G LE +LL +GA V N G P+
Sbjct: 1065 KEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPL 1116
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 85.1 bits (209), Expect = 6e-17
Identities = 55/156 (35%), Positives = 89/156 (57%), Gaps = 2/156 (1%)
Query: 26 IAAIRSFPHDNVEDLIRGGADVN-CTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDG 84
+ A R+ D V + ++GG D+N C L LH A V+ LL +G+ V++
Sbjct: 15 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 74
Query: 85 YNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGAS 143
TALH A+ +A V+VL++ GAN NA N TPL+ AA +N+ + V+ LLE+GA+
Sbjct: 75 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 134
Query: 144 VNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRV 179
+ + TPL+ A +G+ ++V+ILL+ + +V
Sbjct: 135 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV 170
Score = 84.7 bits (208), Expect = 8e-17
Identities = 60/158 (37%), Positives = 84/158 (53%), Gaps = 3/158 (1%)
Query: 34 HDNVEDLI--RGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALH 91
HD V +L+ RG + T L PLH A +CV+ LL+ A V+ + TALH
Sbjct: 290 HDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALH 349
Query: 92 YAAEKDEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYN 150
AA V ++LL+ ANPNA N TPLH A KN + + L++ GAS+ A+ +
Sbjct: 350 VAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES 409
Query: 151 NDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
TP+ AA G+L V +LL GA V N+ G+T +
Sbjct: 410 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 447
Score = 83.2 bits (204), Expect = 2e-16
Identities = 54/152 (35%), Positives = 82/152 (53%), Gaps = 2/152 (1%)
Query: 40 LIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE 98
L+ GA+ N T + PLH A D V LLL+KGA ++ T+LH AA++D+
Sbjct: 627 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDK 686
Query: 99 ACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSW 157
V ++L ++GA+ +A TPL A N + V LL+ GA+VNA N TPL
Sbjct: 687 VNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQ 746
Query: 158 AAMKGNLESVSILLDYGAEVRVINLIGQTPIS 189
AA +G+ +++LL +GA+ G T ++
Sbjct: 747 AAQQGHTHIINVLLQHGAKPNATTANGNTALA 778
Score = 81.3 bits (199), Expect = 9e-16
Identities = 53/147 (36%), Positives = 72/147 (48%), Gaps = 1/147 (0%)
Query: 43 GGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVE 102
G A T PLH A D +LLL++ A ++ T LH AA D V
Sbjct: 532 GAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVA 591
Query: 103 VLL-EYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMK 161
+LL E GA+P+A N TPLH AA KN + LL GA N + TPL A+ +
Sbjct: 592 LLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE 651
Query: 162 GNLESVSILLDYGAEVRVINLIGQTPI 188
G+ + V++LLD GA + + G T +
Sbjct: 652 GHTDMVTLLLDKGANIHMSTKSGLTSL 678
Score = 79.0 bits (193), Expect = 5e-15
Identities = 55/150 (36%), Positives = 76/150 (50%), Gaps = 1/150 (0%)
Query: 40 LIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA 99
L RGG T L PLHCA VELLLE+GA + A + LH AA+ D
Sbjct: 265 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 324
Query: 100 -CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWA 158
CV+ LL++ A + + + T LH AA + + LL+ A+ NA N TPL A
Sbjct: 325 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 384
Query: 159 AMKGNLESVSILLDYGAEVRVINLIGQTPI 188
K ++ + +L+ YGA ++ I G TPI
Sbjct: 385 CKKNRIKVMELLVKYGASIQAITESGLTPI 414
Score = 73.2 bits (178), Expect = 3e-13
Identities = 48/134 (35%), Positives = 67/134 (50%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNAL 114
PLH AC + +ELL++ GA + A+ T +H AA V +LL+ GA+P+
Sbjct: 380 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 439
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ +T LH AA E VR LL +GA V+A TPL A+ G E V +LL +
Sbjct: 440 NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 499
Query: 175 AEVRVINLIGQTPI 188
A G TP+
Sbjct: 500 AHPDAATTNGYTPL 513
Score = 68.9 bits (167), Expect = 5e-12
Identities = 57/156 (36%), Positives = 82/156 (52%), Gaps = 6/156 (3%)
Query: 37 VEDLIRGGADVN-CTHGTLKPLHCACMVSDADCVELLLEKGAEVNA--LDGYNRTALHYA 93
V+ L++ A V+ T L LH A +LLL+K A NA L+G+ T LH A
Sbjct: 327 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGF--TPLHIA 384
Query: 94 AEKDEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNND 152
+K+ V E+L++YGA+ A+ + TP+H AAF + V LL++GAS + + +
Sbjct: 385 CKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE 444
Query: 153 TPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
T L AA G +E V LL GA V QTP+
Sbjct: 445 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 480
Score = 65.5 bits (158), Expect = 5e-11
Identities = 61/202 (30%), Positives = 88/202 (43%), Gaps = 25/202 (12%)
Query: 40 LIRGGA--DVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKD 97
L++ GA DV G LH A + V LL GA V+A +T LH A+
Sbjct: 429 LLQNGASPDVTNIRGETA-LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLG 487
Query: 98 EA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLS 156
+ V++LL++ A+P+A N TPLH +A + + LLE+GA+ + TPL
Sbjct: 488 KTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH 547
Query: 157 WAAMKGNLESVSILLDYGAEVRVINLIGQTPI-------SRLVALLVRGLGTEKEDSCFE 209
AA G+L+ +LL A G TP+ ++ VALL
Sbjct: 548 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL-------------- 593
Query: 210 LLHRAVGHFELRKNGTMPREVA 231
LL + KNG P +A
Sbjct: 594 LLEKGASPHATAKNGYTPLHIA 615
Score = 63.9 bits (154), Expect = 2e-10
Identities = 41/131 (31%), Positives = 67/131 (51%), Gaps = 1/131 (0%)
Query: 60 ACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNR 118
A + D V L+ G ++N + ALH AA++ V+ LL G++ ++
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 119 DTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVR 178
+T LH A+ AE V+ L++ GA++NA N TPL AA + +++ V LL+ GA
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136
Query: 179 VINLIGQTPIS 189
G TP++
Sbjct: 137 TATEDGFTPLA 147
Score = 61.2 bits (147), Expect = 1e-09
Identities = 56/191 (29%), Positives = 80/191 (41%), Gaps = 39/191 (20%)
Query: 37 VEDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAE-------------VNAL 82
V+ L++ GA++N + PL+ A + D V+ LLE GA V
Sbjct: 92 VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQ 151
Query: 83 DGYNRT----------------ALHYAAEKDEACVEVLL---EYGANP------NALDGN 117
G+N+ ALH AA KD+ LL ++ A+ N +
Sbjct: 152 QGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTES 211
Query: 118 RDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEV 177
TPLH AA N LL GA+V+ N TPL A+ +GN V +LLD G ++
Sbjct: 212 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 271
Query: 178 RVINLIGQTPI 188
G TP+
Sbjct: 272 DAKTRDGLTPL 282
Score = 61.2 bits (147), Expect = 1e-09
Identities = 45/134 (33%), Positives = 65/134 (48%), Gaps = 1/134 (0%)
Query: 50 THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYG 108
T PLH A + + LLL +GA V+ T LH A+++ V++LL+ G
Sbjct: 209 TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 268
Query: 109 ANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVS 168
+A + TPLH AA + + V LLE GA + A N +PL AA ++E V
Sbjct: 269 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVK 328
Query: 169 ILLDYGAEVRVINL 182
LL + A V + L
Sbjct: 329 HLLQHKAPVDDVTL 342
Score = 55.5 bits (132), Expect = 5e-08
Identities = 47/144 (32%), Positives = 66/144 (45%), Gaps = 9/144 (6%)
Query: 54 LKPLHCACMVSDADCVELLLEK--GAEVNALDGYNRTA------LHYAAEKDEACVE-VL 104
L LH A D LLL+ A+V + NRT LH AA V +L
Sbjct: 172 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 231
Query: 105 LEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNL 164
L GA + N TPLH A+ + N V+ LL+ G ++A + TPL AA G+
Sbjct: 232 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD 291
Query: 165 ESVSILLDYGAEVRVINLIGQTPI 188
+ V +LL+ GA + G +P+
Sbjct: 292 QVVELLLERGAPLLARTKNGLSPL 315
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 85.1 bits (209), Expect = 6e-17
Identities = 55/156 (35%), Positives = 89/156 (57%), Gaps = 2/156 (1%)
Query: 26 IAAIRSFPHDNVEDLIRGGADVN-CTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDG 84
+ A R+ D V + ++GG D+N C L LH A V+ LL +G+ V++
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 85 YNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGAS 143
TALH A+ +A V+VL++ GAN NA N TPL+ AA +N+ + V+ LLE+GA+
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 144 VNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRV 179
+ + TPL+ A +G+ ++V+ILL+ + +V
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV 191
Score = 84.7 bits (208), Expect = 8e-17
Identities = 60/158 (37%), Positives = 84/158 (53%), Gaps = 3/158 (1%)
Query: 34 HDNVEDLI--RGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALH 91
HD V +L+ RG + T L PLH A +CV+ LL+ A V+ + TALH
Sbjct: 311 HDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALH 370
Query: 92 YAAEKDEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYN 150
AA V ++LL+ ANPNA N TPLH A KN + + L++ GAS+ A+ +
Sbjct: 371 VAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES 430
Query: 151 NDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
TP+ AA G+L V +LL GA V N+ G+T +
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 468
Score = 83.2 bits (204), Expect = 2e-16
Identities = 54/152 (35%), Positives = 82/152 (53%), Gaps = 2/152 (1%)
Query: 40 LIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE 98
L+ GA+ N T + PLH A D V LLL+KGA ++ T+LH AA++D+
Sbjct: 648 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDK 707
Query: 99 ACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSW 157
V ++L ++GA+ +A TPL A N + V LL+ GA+VNA N TPL
Sbjct: 708 VNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQ 767
Query: 158 AAMKGNLESVSILLDYGAEVRVINLIGQTPIS 189
AA +G+ +++LL +GA+ G T ++
Sbjct: 768 AAQQGHTHIINVLLQHGAKPNATTANGNTALA 799
Score = 81.3 bits (199), Expect = 9e-16
Identities = 53/147 (36%), Positives = 72/147 (48%), Gaps = 1/147 (0%)
Query: 43 GGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVE 102
G A T PLH A D +LLL++ A ++ T LH AA D V
Sbjct: 553 GAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVA 612
Query: 103 VLL-EYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMK 161
+LL E GA+P+A N TPLH AA KN + LL GA N + TPL A+ +
Sbjct: 613 LLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE 672
Query: 162 GNLESVSILLDYGAEVRVINLIGQTPI 188
G+ + V++LLD GA + + G T +
Sbjct: 673 GHTDMVTLLLDKGANIHMSTKSGLTSL 699
Score = 79.0 bits (193), Expect = 5e-15
Identities = 55/150 (36%), Positives = 76/150 (50%), Gaps = 1/150 (0%)
Query: 40 LIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA 99
L RGG T L PLHCA VELLLE+GA + A + LH AA+ D
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 345
Query: 100 -CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWA 158
CV+ LL++ A + + + T LH AA + + LL+ A+ NA N TPL A
Sbjct: 346 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 405
Query: 159 AMKGNLESVSILLDYGAEVRVINLIGQTPI 188
K ++ + +L+ YGA ++ I G TPI
Sbjct: 406 CKKNRIKVMELLVKYGASIQAITESGLTPI 435
Score = 73.2 bits (178), Expect = 3e-13
Identities = 48/134 (35%), Positives = 67/134 (50%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNAL 114
PLH AC + +ELL++ GA + A+ T +H AA V +LL+ GA+P+
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 460
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ +T LH AA E VR LL +GA V+A TPL A+ G E V +LL +
Sbjct: 461 NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Query: 175 AEVRVINLIGQTPI 188
A G TP+
Sbjct: 521 AHPDAATTNGYTPL 534
Score = 68.9 bits (167), Expect = 5e-12
Identities = 57/156 (36%), Positives = 82/156 (52%), Gaps = 6/156 (3%)
Query: 37 VEDLIRGGADVN-CTHGTLKPLHCACMVSDADCVELLLEKGAEVNA--LDGYNRTALHYA 93
V+ L++ A V+ T L LH A +LLL+K A NA L+G+ T LH A
Sbjct: 348 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGF--TPLHIA 405
Query: 94 AEKDEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNND 152
+K+ V E+L++YGA+ A+ + TP+H AAF + V LL++GAS + + +
Sbjct: 406 CKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE 465
Query: 153 TPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
T L AA G +E V LL GA V QTP+
Sbjct: 466 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 501
Score = 65.5 bits (158), Expect = 5e-11
Identities = 61/202 (30%), Positives = 88/202 (43%), Gaps = 25/202 (12%)
Query: 40 LIRGGA--DVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKD 97
L++ GA DV G LH A + V LL GA V+A +T LH A+
Sbjct: 450 LLQNGASPDVTNIRGETA-LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLG 508
Query: 98 EA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLS 156
+ V++LL++ A+P+A N TPLH +A + + LLE+GA+ + TPL
Sbjct: 509 KTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH 568
Query: 157 WAAMKGNLESVSILLDYGAEVRVINLIGQTPI-------SRLVALLVRGLGTEKEDSCFE 209
AA G+L+ +LL A G TP+ ++ VALL
Sbjct: 569 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL-------------- 614
Query: 210 LLHRAVGHFELRKNGTMPREVA 231
LL + KNG P +A
Sbjct: 615 LLEKGASPHATAKNGYTPLHIA 636
Score = 63.9 bits (154), Expect = 2e-10
Identities = 41/131 (31%), Positives = 67/131 (51%), Gaps = 1/131 (0%)
Query: 60 ACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNR 118
A + D V L+ G ++N + ALH AA++ V+ LL G++ ++
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 119 DTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVR 178
+T LH A+ AE V+ L++ GA++NA N TPL AA + +++ V LL+ GA
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 179 VINLIGQTPIS 189
G TP++
Sbjct: 158 TATEDGFTPLA 168
Score = 61.2 bits (147), Expect = 1e-09
Identities = 56/191 (29%), Positives = 80/191 (41%), Gaps = 39/191 (20%)
Query: 37 VEDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAE-------------VNAL 82
V+ L++ GA++N + PL+ A + D V+ LLE GA V
Sbjct: 113 VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQ 172
Query: 83 DGYNRT----------------ALHYAAEKDEACVEVLL---EYGANP------NALDGN 117
G+N+ ALH AA KD+ LL ++ A+ N +
Sbjct: 173 QGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTES 232
Query: 118 RDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEV 177
TPLH AA N LL GA+V+ N TPL A+ +GN V +LLD G ++
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292
Query: 178 RVINLIGQTPI 188
G TP+
Sbjct: 293 DAKTRDGLTPL 303
Score = 61.2 bits (147), Expect = 1e-09
Identities = 45/134 (33%), Positives = 65/134 (48%), Gaps = 1/134 (0%)
Query: 50 THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYG 108
T PLH A + + LLL +GA V+ T LH A+++ V++LL+ G
Sbjct: 230 TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Query: 109 ANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVS 168
+A + TPLH AA + + V LLE GA + A N +PL AA ++E V
Sbjct: 290 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVK 349
Query: 169 ILLDYGAEVRVINL 182
LL + A V + L
Sbjct: 350 HLLQHKAPVDDVTL 363
Score = 55.5 bits (132), Expect = 5e-08
Identities = 47/144 (32%), Positives = 66/144 (45%), Gaps = 9/144 (6%)
Query: 54 LKPLHCACMVSDADCVELLLEK--GAEVNALDGYNRTA------LHYAAEKDEACVE-VL 104
L LH A D LLL+ A+V + NRT LH AA V +L
Sbjct: 193 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 252
Query: 105 LEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNL 164
L GA + N TPLH A+ + N V+ LL+ G ++A + TPL AA G+
Sbjct: 253 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD 312
Query: 165 ESVSILLDYGAEVRVINLIGQTPI 188
+ V +LL+ GA + G +P+
Sbjct: 313 QVVELLLERGAPLLARTKNGLSPL 336
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 85.1 bits (209), Expect = 6e-17
Identities = 55/156 (35%), Positives = 89/156 (57%), Gaps = 2/156 (1%)
Query: 26 IAAIRSFPHDNVEDLIRGGADVN-CTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDG 84
+ A R+ D V + ++GG D+N C L LH A V+ LL +G+ V++
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 85 YNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGAS 143
TALH A+ +A V+VL++ GAN NA N TPL+ AA +N+ + V+ LLE+GA+
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 144 VNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRV 179
+ + TPL+ A +G+ ++V+ILL+ + +V
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV 191
Score = 84.7 bits (208), Expect = 8e-17
Identities = 60/158 (37%), Positives = 84/158 (53%), Gaps = 3/158 (1%)
Query: 34 HDNVEDLI--RGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALH 91
HD V +L+ RG + T L PLH A +CV+ LL+ A V+ + TALH
Sbjct: 311 HDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALH 370
Query: 92 YAAEKDEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYN 150
AA V ++LL+ ANPNA N TPLH A KN + + L++ GAS+ A+ +
Sbjct: 371 VAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES 430
Query: 151 NDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
TP+ AA G+L V +LL GA V N+ G+T +
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 468
Score = 83.2 bits (204), Expect = 2e-16
Identities = 54/152 (35%), Positives = 82/152 (53%), Gaps = 2/152 (1%)
Query: 40 LIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE 98
L+ GA+ N T + PLH A D V LLL+KGA ++ T+LH AA++D+
Sbjct: 648 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDK 707
Query: 99 ACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSW 157
V ++L ++GA+ +A TPL A N + V LL+ GA+VNA N TPL
Sbjct: 708 VNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQ 767
Query: 158 AAMKGNLESVSILLDYGAEVRVINLIGQTPIS 189
AA +G+ +++LL +GA+ G T ++
Sbjct: 768 AAQQGHTHIINVLLQHGAKPNATTANGNTALA 799
Score = 81.3 bits (199), Expect = 9e-16
Identities = 53/147 (36%), Positives = 72/147 (48%), Gaps = 1/147 (0%)
Query: 43 GGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVE 102
G A T PLH A D +LLL++ A ++ T LH AA D V
Sbjct: 553 GAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVA 612
Query: 103 VLL-EYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMK 161
+LL E GA+P+A N TPLH AA KN + LL GA N + TPL A+ +
Sbjct: 613 LLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE 672
Query: 162 GNLESVSILLDYGAEVRVINLIGQTPI 188
G+ + V++LLD GA + + G T +
Sbjct: 673 GHTDMVTLLLDKGANIHMSTKSGLTSL 699
Score = 79.0 bits (193), Expect = 5e-15
Identities = 55/150 (36%), Positives = 76/150 (50%), Gaps = 1/150 (0%)
Query: 40 LIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA 99
L RGG T L PLHCA VELLLE+GA + A + LH AA+ D
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 345
Query: 100 -CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWA 158
CV+ LL++ A + + + T LH AA + + LL+ A+ NA N TPL A
Sbjct: 346 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 405
Query: 159 AMKGNLESVSILLDYGAEVRVINLIGQTPI 188
K ++ + +L+ YGA ++ I G TPI
Sbjct: 406 CKKNRIKVMELLVKYGASIQAITESGLTPI 435
Score = 73.2 bits (178), Expect = 3e-13
Identities = 48/134 (35%), Positives = 67/134 (50%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNAL 114
PLH AC + +ELL++ GA + A+ T +H AA V +LL+ GA+P+
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 460
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ +T LH AA E VR LL +GA V+A TPL A+ G E V +LL +
Sbjct: 461 NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Query: 175 AEVRVINLIGQTPI 188
A G TP+
Sbjct: 521 AHPDAATTNGYTPL 534
Score = 68.9 bits (167), Expect = 5e-12
Identities = 57/156 (36%), Positives = 82/156 (52%), Gaps = 6/156 (3%)
Query: 37 VEDLIRGGADVN-CTHGTLKPLHCACMVSDADCVELLLEKGAEVNA--LDGYNRTALHYA 93
V+ L++ A V+ T L LH A +LLL+K A NA L+G+ T LH A
Sbjct: 348 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGF--TPLHIA 405
Query: 94 AEKDEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNND 152
+K+ V E+L++YGA+ A+ + TP+H AAF + V LL++GAS + + +
Sbjct: 406 CKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE 465
Query: 153 TPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
T L AA G +E V LL GA V QTP+
Sbjct: 466 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 501
Score = 65.5 bits (158), Expect = 5e-11
Identities = 61/202 (30%), Positives = 88/202 (43%), Gaps = 25/202 (12%)
Query: 40 LIRGGA--DVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKD 97
L++ GA DV G LH A + V LL GA V+A +T LH A+
Sbjct: 450 LLQNGASPDVTNIRGETA-LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLG 508
Query: 98 EA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLS 156
+ V++LL++ A+P+A N TPLH +A + + LLE+GA+ + TPL
Sbjct: 509 KTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH 568
Query: 157 WAAMKGNLESVSILLDYGAEVRVINLIGQTPI-------SRLVALLVRGLGTEKEDSCFE 209
AA G+L+ +LL A G TP+ ++ VALL
Sbjct: 569 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL-------------- 614
Query: 210 LLHRAVGHFELRKNGTMPREVA 231
LL + KNG P +A
Sbjct: 615 LLEKGASPHATAKNGYTPLHIA 636
Score = 63.9 bits (154), Expect = 2e-10
Identities = 41/131 (31%), Positives = 67/131 (51%), Gaps = 1/131 (0%)
Query: 60 ACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNR 118
A + D V L+ G ++N + ALH AA++ V+ LL G++ ++
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 119 DTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVR 178
+T LH A+ AE V+ L++ GA++NA N TPL AA + +++ V LL+ GA
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 179 VINLIGQTPIS 189
G TP++
Sbjct: 158 TATEDGFTPLA 168
Score = 61.2 bits (147), Expect = 1e-09
Identities = 56/191 (29%), Positives = 80/191 (41%), Gaps = 39/191 (20%)
Query: 37 VEDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAE-------------VNAL 82
V+ L++ GA++N + PL+ A + D V+ LLE GA V
Sbjct: 113 VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQ 172
Query: 83 DGYNRT----------------ALHYAAEKDEACVEVLL---EYGANP------NALDGN 117
G+N+ ALH AA KD+ LL ++ A+ N +
Sbjct: 173 QGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTES 232
Query: 118 RDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEV 177
TPLH AA N LL GA+V+ N TPL A+ +GN V +LLD G ++
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292
Query: 178 RVINLIGQTPI 188
G TP+
Sbjct: 293 DAKTRDGLTPL 303
Score = 61.2 bits (147), Expect = 1e-09
Identities = 45/134 (33%), Positives = 65/134 (48%), Gaps = 1/134 (0%)
Query: 50 THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYG 108
T PLH A + + LLL +GA V+ T LH A+++ V++LL+ G
Sbjct: 230 TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Query: 109 ANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVS 168
+A + TPLH AA + + V LLE GA + A N +PL AA ++E V
Sbjct: 290 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVK 349
Query: 169 ILLDYGAEVRVINL 182
LL + A V + L
Sbjct: 350 HLLQHKAPVDDVTL 363
Score = 55.5 bits (132), Expect = 5e-08
Identities = 47/144 (32%), Positives = 66/144 (45%), Gaps = 9/144 (6%)
Query: 54 LKPLHCACMVSDADCVELLLEK--GAEVNALDGYNRTA------LHYAAEKDEACVE-VL 104
L LH A D LLL+ A+V + NRT LH AA V +L
Sbjct: 193 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 252
Query: 105 LEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNL 164
L GA + N TPLH A+ + N V+ LL+ G ++A + TPL AA G+
Sbjct: 253 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD 312
Query: 165 ESVSILLDYGAEVRVINLIGQTPI 188
+ V +LL+ GA + G +P+
Sbjct: 313 QVVELLLERGAPLLARTKNGLSPL 336
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 85.1 bits (209), Expect = 6e-17
Identities = 57/158 (36%), Positives = 84/158 (53%), Gaps = 3/158 (1%)
Query: 34 HDNVEDLI--RGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALH 91
H+ V +++ R ++ T L PLH A +CV+LLL+ V+ + TALH
Sbjct: 313 HEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALH 372
Query: 92 YAAEKDEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYN 150
AA V +VLL+ ANPNA N TPLH A KN + + LL+ GAS+ A+ +
Sbjct: 373 VAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTES 432
Query: 151 NDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
TP+ AA G++ VS L+ +GA N+ G+T +
Sbjct: 433 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETAL 470
Score = 82.4 bits (202), Expect = 4e-16
Identities = 59/178 (33%), Positives = 96/178 (53%), Gaps = 6/178 (3%)
Query: 26 IAAIRSFPHDNVEDLIRGGADVN-CTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDG 84
+ A R+ + D I+ G D+N C L LH A + V LL++ A V+A
Sbjct: 46 LRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATK 105
Query: 85 YNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGAS 143
TALH A+ +A V+VL+ GAN NA N TPL+ AA +N+ E V+ LL++GAS
Sbjct: 106 KGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS 165
Query: 144 VNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRV----INLIGQTPISRLVALLVR 197
+ + TPL+ A +G+ + VS+LL+ + +V +++ + ++ ALL++
Sbjct: 166 QSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQ 223
Score = 82.4 bits (202), Expect = 4e-16
Identities = 53/154 (34%), Positives = 80/154 (51%), Gaps = 2/154 (1%)
Query: 37 VEDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAE 95
+E L++ GA + T L P+H A + + V L+ GA N + TALH AA
Sbjct: 416 MELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAAR 475
Query: 96 KDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTP 154
+A V L++ GA A + TPLH +A A+ V+ LL+ GAS NA + TP
Sbjct: 476 SGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTP 535
Query: 155 LSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
L +A +G+ + + LLD+GA + + G TP+
Sbjct: 536 LHLSAREGHEDVAAFLLDHGASLSITTKKGFTPL 569
Score = 81.3 bits (199), Expect = 9e-16
Identities = 52/134 (38%), Positives = 69/134 (51%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLL-EYGANPNAL 114
PLH A + LLL+K A +A T LH AA D V +LL + GA+P+A
Sbjct: 568 PLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAA 627
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
N TPLH AA KN + LLE GA NA+ + AA +G+++ VS+LL
Sbjct: 628 AKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRN 687
Query: 175 AEVRVINLIGQTPI 188
A V + N G TP+
Sbjct: 688 ANVNLSNKSGLTPL 701
Score = 79.0 bits (193), Expect = 5e-15
Identities = 49/134 (36%), Positives = 67/134 (50%), Gaps = 1/134 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNAL 114
PLH AC + +ELLL+ GA + A+ T +H AA V L+ +GA+PN
Sbjct: 403 PLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTT 462
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ +T LH AA AE VR L++ GA V A ++ TPL +A G + V LL G
Sbjct: 463 NVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQG 522
Query: 175 AEVRVINLIGQTPI 188
A G TP+
Sbjct: 523 ASPNAATTSGYTPL 536
Score = 77.0 bits (188), Expect = 2e-14
Identities = 54/156 (34%), Positives = 74/156 (47%), Gaps = 2/156 (1%)
Query: 35 DNVEDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYA 93
D L+ GAD N T + +H A D V LLL + A VN + T LH A
Sbjct: 645 DIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLA 704
Query: 94 AEKDEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNND 152
A++D V EVL+ GA+ +A TPLH N + V LL+ A VNA N
Sbjct: 705 AQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGY 764
Query: 153 TPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
TPL AA +G+ +++LL A + + G T +
Sbjct: 765 TPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTAL 800
Score = 74.7 bits (182), Expect = 9e-14
Identities = 67/231 (29%), Positives = 99/231 (42%), Gaps = 23/231 (9%)
Query: 37 VEDLIRGGADVNCTHGTLKP-LHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAE 95
V L+ GA N T+ + LH A A+ V L++ GA+V A ++T LH +A
Sbjct: 449 VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 508
Query: 96 KDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTP 154
+A V+ LL+ GA+PNA + TPLH +A + + + LL+ GAS++ TP
Sbjct: 509 LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTP 568
Query: 155 LSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI-------SRLVALLVRGLGTEKEDSC 207
L AA G LE ++LL A G TP+ ++ VALL
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALL------------ 616
Query: 208 FELLHRAVGHFELRKNGTMPREVARDPQLCEKLTVLCSAPGTLKTLARYAV 258
LL + KNG P +A + T L + R +
Sbjct: 617 --LLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI 665
Score = 70.5 bits (171), Expect = 2e-12
Identities = 46/136 (33%), Positives = 70/136 (51%), Gaps = 1/136 (0%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEV-LLEYGANPN 112
L PLH A + LLL++GA +A T LH AA+K++ + LLEYGA+ N
Sbjct: 599 LTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADAN 658
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLD 172
A+ +H AA + + + V LL A+VN + + TPL AA + + +L++
Sbjct: 659 AVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVN 718
Query: 173 YGAEVRVINLIGQTPI 188
GA V +G TP+
Sbjct: 719 QGAHVDAQTKMGYTPL 734
Score = 65.5 bits (158), Expect = 5e-11
Identities = 67/226 (29%), Positives = 93/226 (41%), Gaps = 38/226 (16%)
Query: 37 VEDLIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNAL--DGY-------- 85
V+ L+ GA+VN + PL+ A + + V+ LL+ GA + DG+
Sbjct: 123 VKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQ 182
Query: 86 ------------NRT-------ALHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWA 125
N T ALH AA KD+ +LL+ N + + TPLH A
Sbjct: 183 QGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIA 242
Query: 126 AFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQ 185
A N LL A+V+ N+ TPL A+ +GN V +LLD GA++ G
Sbjct: 243 AHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGL 302
Query: 186 TPISRLVALLVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREVA 231
TP L G + E LL RA KNG P +A
Sbjct: 303 TP-------LHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMA 341
Score = 55.8 bits (133), Expect = 4e-08
Identities = 42/134 (31%), Positives = 64/134 (47%), Gaps = 2/134 (1%)
Query: 45 ADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEV 103
ADV G PLH A + + LLL + A V+ + T LH A+++ A V++
Sbjct: 228 ADVESKSG-FTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKL 286
Query: 104 LLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGN 163
LL+ GA +A + TPLH A + + V LL+ A + + N +PL A +
Sbjct: 287 LLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDH 346
Query: 164 LESVSILLDYGAEV 177
L V +LL + V
Sbjct: 347 LNCVQLLLQHNVPV 360
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 84.3 bits (207), Expect = 1e-16
Identities = 57/151 (37%), Positives = 82/151 (54%), Gaps = 2/151 (1%)
Query: 40 LIRGGADVNC-THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEK-D 97
L+R GA + TH PLH A + + LL E A + AL N T LH AA +
Sbjct: 579 LLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGE 638
Query: 98 EACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSW 157
EA V LL+ GA+PNA + + TPLH A ++ V LLE A+V+A + TP
Sbjct: 639 EAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHL 698
Query: 158 AAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
AA+KGN + +L++ GA++ V + + TP+
Sbjct: 699 AALKGNTAILKVLVEAGAQLDVQDGVSCTPL 729
Score = 77.4 bits (189), Expect = 1e-14
Identities = 53/151 (35%), Positives = 77/151 (50%), Gaps = 2/151 (1%)
Query: 40 LIRGGADVNCTHGTLK-PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE 98
L+ AD N K PLH A V+LL +GAE++A RT LH A E+ +
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
Query: 99 A-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSW 157
++ LL+ GA P+ALD + PLH AA + + LL GAS+ + TPL
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
Query: 158 AAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
AA KG+LE + +L + A + + + TP+
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPL 630
Score = 71.2 bits (173), Expect = 1e-12
Identities = 51/156 (32%), Positives = 73/156 (46%), Gaps = 2/156 (1%)
Query: 40 LIRGGADVN-CTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKD- 97
L+ GAD N PLH A D LLL+ GA V+A + T LH AA+ +
Sbjct: 414 LLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNF 473
Query: 98 EACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSW 157
E +L+ A+PN + TPLH AA+ + V+ L GA ++A N TPL
Sbjct: 474 ENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHL 533
Query: 158 AAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVA 193
A +G + ++ LL GA ++ G P+ A
Sbjct: 534 AVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAA 569
Score = 54.7 bits (130), Expect = 9e-08
Identities = 43/135 (31%), Positives = 68/135 (50%), Gaps = 3/135 (2%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACV-EVLLEYGANPNAL 114
PLH + V LLL +V+ T L AA+ + + +LL +GA+ N +
Sbjct: 365 PLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRV 424
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVS-ILLDY 173
D + PLH+AA + R LL+ GA V+A + TPL AA + N E+V+ +L+
Sbjct: 425 DEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAA-QNNFENVARLLVSR 483
Query: 174 GAEVRVINLIGQTPI 188
A+ + G+TP+
Sbjct: 484 QADPNLHEAEGKTPL 498
Score = 37.0 bits (84), Expect = 0.020
Identities = 22/72 (30%), Positives = 36/72 (50%)
Query: 117 NRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAE 176
N+ TPLH+ + + E VR LL V+ + TPL AA + ++LL +GA+
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
Query: 177 VRVINLIGQTPI 188
++ G P+
Sbjct: 421 ANRVDEDGWAPL 432
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 83.2 bits (204), Expect = 2e-16
Identities = 51/137 (37%), Positives = 71/137 (51%), Gaps = 4/137 (2%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKD-EACVEVLLEYGANPNAL 114
PLH A + A ++LL+ KGA VNA D + T LH A +K ++ +LL Y A+
Sbjct: 466 PLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQ 525
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNN---DTPLSWAAMKGNLESVSILL 171
D N +TPLH A + +CV+AL+ LD N DTPL AA G + LL
Sbjct: 526 DNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLL 585
Query: 172 DYGAEVRVINLIGQTPI 188
GA + N + +TP+
Sbjct: 586 QNGASTEIQNRLKETPL 602
Score = 75.1 bits (183), Expect = 7e-14
Identities = 50/146 (34%), Positives = 78/146 (53%), Gaps = 2/146 (1%)
Query: 44 GADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE-ACVE 102
G +V G+ PLH A + AD + LLL+ GA A + LH A ++ V+
Sbjct: 736 GVNVTSQDGS-SPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVK 794
Query: 103 VLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKG 162
LL+ A PN D + +TPL +A + E V LL+ GAS+NA + +T L A ++
Sbjct: 795 CLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEK 854
Query: 163 NLESVSILLDYGAEVRVINLIGQTPI 188
++ V +LL +GA V+V+N +T +
Sbjct: 855 HVFVVELLLLHGASVQVLNKRQRTAV 880
Score = 66.6 bits (161), Expect = 2e-11
Identities = 41/118 (34%), Positives = 64/118 (54%), Gaps = 3/118 (2%)
Query: 76 GAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECV 134
G V + DG + LH AA A + +LL++GAN A + ++ PLH A + + + V
Sbjct: 736 GVNVTSQDG--SSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVV 793
Query: 135 RALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLV 192
+ LL+S A N D + +TPL +A G+ E V++LL +GA + N G T + V
Sbjct: 794 KCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAV 851
Score = 56.6 bits (135), Expect = 2e-08
Identities = 47/128 (36%), Positives = 57/128 (44%), Gaps = 7/128 (5%)
Query: 37 VEDLIRGGADVNCT--HGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA 94
++ L+ GA VN T HG PLH AC LLL A D T LH A
Sbjct: 479 IDLLVSKGAMVNATDYHGAT-PLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLAC 537
Query: 95 EKD-EACVEVLLEYGANPNALD-GNR--DTPLHWAAFKNNAECVRALLESGASVNALDYN 150
E CV+ L+ Y LD GN DTPLH AA + LL++GAS +
Sbjct: 538 TYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRL 597
Query: 151 NDTPLSWA 158
+TPL A
Sbjct: 598 KETPLKCA 605
Score = 53.5 bits (127), Expect = 2e-07
Identities = 40/132 (30%), Positives = 59/132 (44%), Gaps = 2/132 (1%)
Query: 35 DNVEDLIRGGADVNCTHGTLK-PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYA 93
D + L++ GA+ + PLH AC V+ LL+ A+ N D T L YA
Sbjct: 758 DLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYA 817
Query: 94 AEKDE-ACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNND 152
V +LL++GA+ NA + +T LH A + + V LL GASV L+
Sbjct: 818 CSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQR 877
Query: 153 TPLSWAAMKGNL 164
T + A +
Sbjct: 878 TAVDCAEQNSKI 889
Score = 53.1 bits (126), Expect = 3e-07
Identities = 31/78 (39%), Positives = 38/78 (48%)
Query: 111 PNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSIL 170
P + D TPLH AA A + L+ GA VNA DY+ TPL A KG +L
Sbjct: 456 PFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLL 515
Query: 171 LDYGAEVRVINLIGQTPI 188
L Y A V + G TP+
Sbjct: 516 LHYKASAEVQDNNGNTPL 533
Score = 48.9 bits (115), Expect = 5e-06
Identities = 33/98 (33%), Positives = 50/98 (51%), Gaps = 10/98 (10%)
Query: 108 GANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESV 167
G N + DG+ +PLH AA A+ + LL+ GA+ A + + PL A +G+ + V
Sbjct: 736 GVNVTSQDGS--SPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVV 793
Query: 168 SILLDYGAEVRVINLIGQTPI--------SRLVALLVR 197
LLD A+ +L G TP+ LVALL++
Sbjct: 794 KCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQ 831
Score = 30.0 bits (66), Expect = 2.5
Identities = 15/49 (30%), Positives = 23/49 (46%)
Query: 140 SGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
SG VN + +PL AA+ G + + +LL +GA N P+
Sbjct: 733 SGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPL 781
>gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isoform
a [Homo sapiens]
Length = 426
Score = 82.8 bits (203), Expect = 3e-16
Identities = 88/328 (26%), Positives = 131/328 (39%), Gaps = 83/328 (25%)
Query: 40 LIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA 99
L+ A +NC PLH AC +++ DCV++L ++GA++N TALH+
Sbjct: 94 LLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSI 153
Query: 100 -CVEVLLEYGANPNALDGNRD--TPLHWAAFKNNAECV---------------------- 134
C + L+ GAN N N+D TPLH AA +E V
Sbjct: 154 LCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLA 213
Query: 135 ----------------------RALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLD 172
R LL+ A VNA D + +PL AA + + ++L+
Sbjct: 214 IAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLE 273
Query: 173 YGAEVRVINLIGQTPISRLVALLVRGLGTEKE--------------------------DS 206
GAE ++++ G I ++ + + E S
Sbjct: 274 AGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHS 333
Query: 207 CFELLHRAVGHFELRKNGTMPREVARDPQLCEK--------LTVLCSAPGTLKTLARYAV 258
C + + V +E + T R D L EK TV C++P TL L+R A+
Sbjct: 334 CPKAIEVVVNAYEHIRWNTKWRRAIPDDDL-EKYWDFYHSLFTVCCNSPRTLMHLSRCAI 392
Query: 259 RRSLGLQYLPDAVKGLPLPASLKEYLLL 286
RR+L A+ L LP SLK+YLLL
Sbjct: 393 RRTLH-NRCHRAIPLLSLPLSLKKYLLL 419
Score = 64.7 bits (156), Expect = 9e-11
Identities = 43/136 (31%), Positives = 69/136 (50%), Gaps = 4/136 (2%)
Query: 57 LHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALD 115
LH + + +C+ +LL+ A +N +T LH A E CV++L + GA N
Sbjct: 79 LHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAKLNCYS 137
Query: 116 GNRDTPLHWAAFKNNAECVRALLESGASVNALDYNND--TPLSWAAMKGNLESVSILLDY 173
+ T LH+ ++ C + L+ GA+VN N D TPL AA G E V+ +++
Sbjct: 138 LSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEH 197
Query: 174 GAEVRVINLIGQTPIS 189
GA V +N +TP++
Sbjct: 198 GAIVDSVNAHMETPLA 213
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 82.8 bits (203), Expect = 3e-16
Identities = 48/125 (38%), Positives = 69/125 (55%), Gaps = 1/125 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNAL 114
P H A +C+ +LL GA++N+ + TALH A + CV+VLL++GAN +A+
Sbjct: 57 PFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAV 116
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
D +PLHWAA A V L + A ++ LD + TPL A++ G+ S LL G
Sbjct: 117 DAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRG 176
Query: 175 AEVRV 179
A V V
Sbjct: 177 ARVNV 181
Score = 78.2 bits (191), Expect = 8e-15
Identities = 51/147 (34%), Positives = 78/147 (53%), Gaps = 2/147 (1%)
Query: 40 LIRGGADVNCTHGT-LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE 98
L+ GAD+N + LH A + CV++LL+ GA +A+D NR+ LH+AA
Sbjct: 73 LLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGC 132
Query: 99 ACVEVLL-EYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSW 157
A +LL ++ A + LD + TPL A+ +A LL+ GA VN D N+ + L
Sbjct: 133 ASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALIL 192
Query: 158 AAMKGNLESVSILLDYGAEVRVINLIG 184
A KG+ E +LL +GA+ ++ G
Sbjct: 193 ACEKGSAEVAELLLSHGADAGAVDSTG 219
Score = 75.9 bits (185), Expect = 4e-14
Identities = 50/144 (34%), Positives = 74/144 (51%), Gaps = 8/144 (5%)
Query: 71 LLLEKGAEVNALDGYNRTALHYAAEKD-EACVEVLLEYGANPNALDGNRDTPLHWAAFKN 129
L K A LD ++ H AA K C+ +LL GA+ N+ + + T LH A
Sbjct: 39 LASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISC 98
Query: 130 NAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPIS 189
+CV+ LL+ GA+ +A+D N +PL WAA G SV +L D+ A + V++ G+TP
Sbjct: 99 QPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTP-- 156
Query: 190 RLVALLVRGLGTEKEDSCFELLHR 213
L++ LG C +LL R
Sbjct: 157 ----LMIASLGGHAA-ICSQLLQR 175
Score = 44.3 bits (103), Expect = 1e-04
Identities = 28/71 (39%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACV-EVLLEYGANPNAL 114
PL A + A LL++GA VN D +++AL A EK A V E+LL +GA+ A+
Sbjct: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
Query: 115 DGNRDTPLHWA 125
D LH+A
Sbjct: 216 DSTGHDALHYA 226
Score = 39.3 bits (90), Expect = 0.004
Identities = 27/80 (33%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 40 LIRGGADVNCTHGTLKP-LHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE 98
L++ GA VN T K L AC A+ ELLL GA+ A+D ALHYA +
Sbjct: 172 LLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQD 231
Query: 99 ACVEVLLEYGANPNALDGNR 118
+ L+ + G R
Sbjct: 232 KALWRHLQQALSRRRRGGQR 251
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 82.8 bits (203), Expect = 3e-16
Identities = 54/154 (35%), Positives = 82/154 (53%), Gaps = 2/154 (1%)
Query: 35 DNVEDLIRGGADVNCTHGTLKP-LHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYA 93
D VE L GADVNC +P L+ + + E LE GA V A D RTALH +
Sbjct: 927 DIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVS 986
Query: 94 AEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNND 152
+ V+VL+ Y A+ NA D + + L AA++ + + V+ L+E GA V+
Sbjct: 987 CWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGA 1046
Query: 153 TPLSWAAMKGNLESVSILLDYGAEVRVINLIGQT 186
T L AA +G+++ V +LL++GA+ + G+T
Sbjct: 1047 TALCIAAQEGHIDVVQVLLEHGADPNHADQFGRT 1080
Score = 79.0 bits (193), Expect = 5e-15
Identities = 72/202 (35%), Positives = 102/202 (50%), Gaps = 19/202 (9%)
Query: 35 DNVEDLIRGGADVNCTHGTLKP-LHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYA 93
D V +L++ GA+VN + L A + + VE LL+ GAEVN D RTAL A
Sbjct: 658 DIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717
Query: 94 A------EKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNAL 147
A + + V +L++ GA + D + TPL AA++ + + V LLE GA V+
Sbjct: 718 ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT 777
Query: 148 DYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVA---------LLVRG 198
D N TPL AA G+ V+ LL +GA V I+ G+T +S A LL RG
Sbjct: 778 DNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837
Query: 199 LG-TEKEDSCFELLHRAV--GH 217
L ++D+ + LH A GH
Sbjct: 838 LDENHRDDAGWTPLHMAAFEGH 859
Score = 76.3 bits (186), Expect = 3e-14
Identities = 52/140 (37%), Positives = 74/140 (52%), Gaps = 2/140 (1%)
Query: 35 DNVEDLIRGGADVNCTHGTLK-PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYA 93
D V+ L+ GGADV+ T + PL A + A V LL GA V+++D RT L A
Sbjct: 762 DVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIA 821
Query: 94 -AEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNND 152
A+ + V LL+ G + N D TPLH AAF+ + AL+E GA N +D +
Sbjct: 822 SAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGR 881
Query: 153 TPLSWAAMKGNLESVSILLD 172
P A+ +G+ + V ILL+
Sbjct: 882 IPFILASQEGHYDCVQILLE 901
Score = 73.2 bits (178), Expect = 3e-13
Identities = 55/150 (36%), Positives = 74/150 (49%), Gaps = 2/150 (1%)
Query: 40 LIRGGADVN-CTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE 98
LI GA+V+ C + PL A D V+LLLE GA+V+ D RT L AA
Sbjct: 734 LIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGH 793
Query: 99 ACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSW 157
A V LL +GA +++D T L A+ + N E VR LL+ G N D TPL
Sbjct: 794 ASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHM 853
Query: 158 AAMKGNLESVSILLDYGAEVRVINLIGQTP 187
AA +G+ L++ GA I+ G+ P
Sbjct: 854 AAFEGHRLICEALIEQGARTNEIDNDGRIP 883
Score = 63.9 bits (154), Expect = 2e-10
Identities = 56/158 (35%), Positives = 72/158 (45%), Gaps = 4/158 (2%)
Query: 35 DNVEDLIRGGADVNC--THGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHY 92
D V L+ GAD+ HG PL A V L+ GA +N D TAL
Sbjct: 559 DVVNLLVSRGADLEIEDAHGHT-PLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRS 617
Query: 93 AAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNN 151
AA V LL G + D + T L AA+ + + V LL+ GA VN D
Sbjct: 618 AAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEG 677
Query: 152 DTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPIS 189
T L AA G+ E V LLD+GAEV ++ G+T +S
Sbjct: 678 RTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALS 715
Score = 62.4 bits (150), Expect = 4e-10
Identities = 46/142 (32%), Positives = 67/142 (47%), Gaps = 2/142 (1%)
Query: 38 EDLIRGGADVNCTHGTLK-PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA-E 95
E LI GA N + P A DCV++LLE + ++ R AL AA E
Sbjct: 864 EALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALE 923
Query: 96 KDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPL 155
VE+L +GA+ N D + L+ A +N LE+GA+V A D T L
Sbjct: 924 GHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTAL 983
Query: 156 SWAAMKGNLESVSILLDYGAEV 177
+ +G++E V +L+ Y A+V
Sbjct: 984 HVSCWQGHMEMVQVLIAYHADV 1005
Score = 62.0 bits (149), Expect = 6e-10
Identities = 43/149 (28%), Positives = 75/149 (50%), Gaps = 8/149 (5%)
Query: 40 LIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA 99
+I G V + TL P + + ++LL++ GA VN+ D + A E++++
Sbjct: 475 MIWNGTPVRDSLSTLIP-------KEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDS 527
Query: 100 CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAA 159
+ LL+ GA+ N D N T L AA+ + + V L+ GA + D + TPL+ AA
Sbjct: 528 -IRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAA 586
Query: 160 MKGNLESVSILLDYGAEVRVINLIGQTPI 188
+G+ + V+ L+ GA + + G T +
Sbjct: 587 RQGHTKVVNCLIGCGANINHTDQDGWTAL 615
Score = 55.5 bits (132), Expect = 5e-08
Identities = 32/103 (31%), Positives = 61/103 (59%), Gaps = 2/103 (1%)
Query: 87 RTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNA 146
R +L K++ +++L++ GA+ N+ D + A + ++ +R LL++GASVN
Sbjct: 483 RDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDS--IRTLLDNGASVNQ 540
Query: 147 LDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPIS 189
D N T L+ AA G+L+ V++L+ GA++ + + G TP++
Sbjct: 541 CDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLT 583
Score = 55.1 bits (131), Expect = 7e-08
Identities = 49/170 (28%), Positives = 73/170 (42%), Gaps = 6/170 (3%)
Query: 24 RTIAAIRSFPHDNVE---DLIRGGADVNCTHGT-LKPLHCACMVSDADCVELLLEKGAEV 79
RT+ +I S NVE L+ G D N PLH A E L+E+GA
Sbjct: 815 RTVLSIAS-AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGART 873
Query: 80 NALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALL 138
N +D R A+++ CV++LLE +N + + L AA + + + V L
Sbjct: 874 NEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLF 933
Query: 139 ESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
GA VN D + L A++ L L+ GA V + G+T +
Sbjct: 934 SHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTAL 983
Score = 48.1 bits (113), Expect = 9e-06
Identities = 38/109 (34%), Positives = 55/109 (50%), Gaps = 2/109 (1%)
Query: 37 VEDLIRGGADVNCTHGTLKP-LHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAE 95
V+ LI ADVN + L A V+LL+E GA V+ TAL AA+
Sbjct: 995 VQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQ 1054
Query: 96 KDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGAS 143
+ V+VLLE+GA+PN D T + AA +++ ++ L + GAS
Sbjct: 1055 EGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103
>gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [Homo
sapiens]
Length = 453
Score = 82.4 bits (202), Expect = 4e-16
Identities = 69/228 (30%), Positives = 103/228 (45%), Gaps = 17/228 (7%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNAL 114
PL A DC L+ +GAE++A G R ALH A + + CV +LL +GA N L
Sbjct: 114 PLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAKANVL 172
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVN-ALDYNNDTPLSWAAMKGNLESVSILLDY 173
TPLH + +C + LLE+GA+VN A + +TPL AA +G + V++ L++
Sbjct: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
Query: 174 GAEVRVINLIGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREVARD 233
GA+V + G+T ++ A G E SC H+A L + G R R
Sbjct: 233 GADVGLRTSQGETALNTACA------GAEGPGSCRR--HQAAAR-RLLEAGADARAAGRK 283
Query: 234 PQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLK 281
G + L RY R +P+ P+ +L+
Sbjct: 284 RHTPLHNACANGCGGLAELLLRYGARAE-----VPNGAGHTPMDCALQ 326
Score = 81.6 bits (200), Expect = 7e-16
Identities = 98/332 (29%), Positives = 129/332 (38%), Gaps = 73/332 (21%)
Query: 26 IAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGY 85
IA R + D LIR GA+++ G LH AC + DCV LLL GA+ N L
Sbjct: 117 IATARGYT-DCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEE 175
Query: 86 NRTALHYAAEKDE-ACVEVLLEYGANPNALDG-NRDTPLHWAAFKN-------------- 129
T LH + C ++LLE GA N G +++TPLH AA +
Sbjct: 176 GTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGAD 235
Query: 130 ------------NAEC---------------VRALLESGASVNALDYNNDTPLSWAAMKG 162
N C R LLE+GA A TPL A G
Sbjct: 236 VGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANG 295
Query: 163 NLESVSILLDYGAEVRVINLIGQTPISRLVALLVRGLGTEKEDSCFELLH---RAVGHFE 219
+LL YGA V N G TP+ + + E E LL + V
Sbjct: 296 CGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPEM 355
Query: 220 LRKNGTMPREV------------------ARDPQLCEK-----LTVLC--SAPGTLKTLA 254
L+ PR + A P+L ++ + LC + P L+ LA
Sbjct: 356 LKHCANFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLA 415
Query: 255 RYAVRRSLGLQYLPDAVKGLPLPASLKEYLLL 286
R AVR LG + A + LPLP L++YLLL
Sbjct: 416 RLAVRARLGSRCRQGATR-LPLPPLLRDYLLL 446
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 82.0 bits (201), Expect = 5e-16
Identities = 54/159 (33%), Positives = 77/159 (48%), Gaps = 4/159 (2%)
Query: 34 HDNVEDLIRGGA-DVNCTHGTLKP--LHCACMVSDADCVELLLEKGAEVNALDGYNRTAL 90
H +V +L+ DVN G +K LH A +C+ LLL+KGA N D T L
Sbjct: 43 HRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPL 102
Query: 91 HYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDY 149
H AA + C+ LLEY A+ N + T +HW A E + L++ + V+ D
Sbjct: 103 HLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDA 162
Query: 150 NNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
T L A G+ +V LLD GA++ N+ G TP+
Sbjct: 163 MGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPL 201
>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
Length = 300
Score = 82.0 bits (201), Expect = 5e-16
Identities = 48/112 (42%), Positives = 67/112 (59%), Gaps = 1/112 (0%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA-EKDEACVEVLLEYGANPN 112
LK L + +D + V+ LLE GA+ A D RTALH+A+ ++ V++LL++GA+PN
Sbjct: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
Query: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNL 164
DG +TPLH AA N+ + LL GA V+ALD TPL A K N+
Sbjct: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
Score = 60.8 bits (146), Expect = 1e-09
Identities = 41/113 (36%), Positives = 59/113 (52%), Gaps = 4/113 (3%)
Query: 76 GAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVR 135
G EV+AL +A D V+ LLE GA+P A D T LH+A+ N + V+
Sbjct: 105 GKEVHALKRLRDSA----NANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQ 160
Query: 136 ALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
LL+ GA N D +TPL AA ++ ++ LL GA V ++ G+TP+
Sbjct: 161 LLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPL 213
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 81.6 bits (200), Expect = 7e-16
Identities = 68/212 (32%), Positives = 101/212 (47%), Gaps = 16/212 (7%)
Query: 26 IAAIRSFPHDNVEDLIRGGADVNCTHGTLK-PLHCACMVSDADCVELLLEKGAEVNALDG 84
+ AI S + V L+ ++N + PLH A V D ++LLL GA VNA D
Sbjct: 13 VQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDT 72
Query: 85 YNRTALHYAA-EKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGAS 143
T LH AA ++E + +LL + A+ NA D TPLH AA +C AL +S
Sbjct: 73 LWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSS 132
Query: 144 VNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVIN-----------LIGQTPISRLV 192
+N D + + L A G+LE+V++LL+ GA + V + +G + +L+
Sbjct: 133 LNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLL 192
Query: 193 ALLVRGLGTEKEDSCFELLHRAV--GHFELRK 222
LG K+ + LLH A G E+ K
Sbjct: 193 VARGADLGC-KDRKGYGLLHTAAASGQIEVVK 223
Score = 76.3 bits (186), Expect = 3e-14
Identities = 52/151 (34%), Positives = 68/151 (45%), Gaps = 2/151 (1%)
Query: 40 LIRGGADVNCTHGTLK-PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE 98
L+ ADVN + PLH A C E L + +N D R+ALH+A
Sbjct: 93 LLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGH 152
Query: 99 A-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSW 157
V +LL GA+ N D PLHWAAF + E ++ L+ GA + D L
Sbjct: 153 LETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHT 212
Query: 158 AAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
AA G +E V LL GAE+ N G T +
Sbjct: 213 AAASGQIEVVKYLLRMGAEIDEPNAFGNTAL 243
Score = 75.9 bits (185), Expect = 4e-14
Identities = 51/152 (33%), Positives = 73/152 (48%), Gaps = 3/152 (1%)
Query: 40 LIRGGADVNCTHGT-LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE 98
L+ GAD+ C LH A + V+ LL GAE++ + + TALH A +
Sbjct: 192 LVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQ 251
Query: 99 ACVEV-LLEYGANPNALDGNRDTPLHWAAFKNN-AECVRALLESGASVNALDYNNDTPLS 156
V + L+ GAN N + TPLH AA N A C+ L+ +GA VN +PL
Sbjct: 252 DAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLH 311
Query: 157 WAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
AA+ G IL+ G+E+ + G TP+
Sbjct: 312 MAAIHGRFTRSQILIQNGSEIDCADKFGNTPL 343
Score = 72.8 bits (177), Expect = 3e-13
Identities = 62/200 (31%), Positives = 95/200 (47%), Gaps = 20/200 (10%)
Query: 27 AAIRSFPHDNVEDLIRGG-----ADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNA 81
AA S D++ LI G DV +G PL A M DCV LLLEKG+ +A
Sbjct: 658 AAAASGHTDSLHLLIDSGERADITDVMDAYGQT-PLMLAIMNGHVDCVHLLLEKGSTADA 716
Query: 82 LDGYNRTALHYAAEKD-EACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLES 140
D RTALH A E C+ LL++ A D TP+H A+ + +R LL++
Sbjct: 717 ADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQA 776
Query: 141 GASVNAL----DYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVALLV 196
S + L DY+ +P+ WA+ G+ + + +LL++ + + P + L ++
Sbjct: 777 ALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSP----FSYLEGNPFTPLHCAVI 832
Query: 197 RGLGTEKEDSCFELLHRAVG 216
+DS E+L A+G
Sbjct: 833 -----NNQDSTTEMLLGALG 847
Score = 72.8 bits (177), Expect = 3e-13
Identities = 51/137 (37%), Positives = 68/137 (49%), Gaps = 5/137 (3%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE-ACVEVLLEYG-ANPNA 113
PLH A + + +LL+ AEVNA D RTAL AAE + A VE LL G A+
Sbjct: 861 PLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTV 920
Query: 114 LDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDT---PLSWAAMKGNLESVSIL 170
LD N++T LH A K + +C +L + ++ N PL AA G V L
Sbjct: 921 LDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQAL 980
Query: 171 LDYGAEVRVINLIGQTP 187
L +GA V ++ G TP
Sbjct: 981 LSHGATVLAVDEEGHTP 997
Score = 67.4 bits (163), Expect = 1e-11
Identities = 45/142 (31%), Positives = 71/142 (50%), Gaps = 5/142 (3%)
Query: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPN 112
+ PLH A + ++ L E ++ D RTAL A E+ CVEVL +GA+
Sbjct: 586 VSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL 645
Query: 113 ALDGNRD-TPLHWAAFKNNAECVRALLESGASVN---ALDYNNDTPLSWAAMKGNLESVS 168
+ R TPLH AA + + + L++SG + +D TPL A M G+++ V
Sbjct: 646 IKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVH 705
Query: 169 ILLDYGAEVRVINLIGQTPISR 190
+LL+ G+ +L G+T + R
Sbjct: 706 LLLEKGSTADAADLRGRTALHR 727
Score = 66.2 bits (160), Expect = 3e-11
Identities = 51/140 (36%), Positives = 70/140 (50%), Gaps = 5/140 (3%)
Query: 46 DVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA-EKDEACVEVL 104
D + P+H A DC+ELLLE + + L+G T LH A ++ E+L
Sbjct: 784 DAGVDYSGYSPMHWASYTGHEDCLELLLEH-SPFSYLEGNPFTPLHCAVINNQDSTTEML 842
Query: 105 L-EYGAN-PNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKG 162
L GA N+ D TPLH AAF +N +R LL+ A VNA D+ T L AA G
Sbjct: 843 LGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENG 902
Query: 163 NLESVSILLDYG-AEVRVIN 181
+V LL G A++ V++
Sbjct: 903 QTAAVEFLLYRGKADLTVLD 922
Score = 60.8 bits (146), Expect = 1e-09
Identities = 47/153 (30%), Positives = 70/153 (45%), Gaps = 7/153 (4%)
Query: 38 EDLIRGGADVNCTHGTLKP-LHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEK 96
E ++ G D+N + LH A + +C+ LLL GA++ D + RT LHYAA
Sbjct: 407 EHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAAN 466
Query: 97 DE-ACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPL 155
C L+ GA N D +PLH+AA + RA + +S +A D PL
Sbjct: 467 GSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYR--RAEPHTPSSHDA---EEDEPL 521
Query: 156 SWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
+ K + LLD GA+ + + G T +
Sbjct: 522 KESRRKEAFFCLEFLLDNGADPSLRDRQGYTAV 554
Score = 60.5 bits (145), Expect = 2e-09
Identities = 40/123 (32%), Positives = 54/123 (43%), Gaps = 19/123 (15%)
Query: 56 PLHCACMVSDADCVELLLEKGA------------------EVNALDGYNRTALHYAAEKD 97
PLH A + +DC LL G ++N D RT LH AA
Sbjct: 375 PLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGG 434
Query: 98 EA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLS 156
C+ +LL GA+ D TPLH+AA + +C L+ +GA VN D +PL
Sbjct: 435 NVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLH 494
Query: 157 WAA 159
+AA
Sbjct: 495 YAA 497
Score = 59.7 bits (143), Expect = 3e-09
Identities = 53/161 (32%), Positives = 80/161 (49%), Gaps = 11/161 (6%)
Query: 22 LIRTIAAIRSFPHDNVEDLIRGGADV---NCTHGTLKPLHCACMVS-DADCVELLLEKGA 77
L+ T AA S + V+ L+R GA++ N T LH AC + DA +EL+ GA
Sbjct: 209 LLHTAAA--SGQIEVVKYLLRMGAEIDEPNAFGNTA--LHIACYLGQDAVAIELV-NAGA 263
Query: 78 EVNALDGYNRTALHYAAEKDEA--CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVR 135
VN + T LH AA C+E+L+ GA+ N +PLH AA +
Sbjct: 264 NVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQ 323
Query: 136 ALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAE 176
L+++G+ ++ D +TPL AA G+ +S L+ GA+
Sbjct: 324 ILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD 364
Score = 58.2 bits (139), Expect = 8e-09
Identities = 38/117 (32%), Positives = 61/117 (52%), Gaps = 7/117 (5%)
Query: 68 CVELLLEKGAEVNALDGYNRTALHYAAEK-DEACVEVLLEYGANPNALDGNRDT----PL 122
C+E LL+ GA+ + D TA+HYAA + +E+LLE N L+ T PL
Sbjct: 532 CLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFN--CLEDVESTIPVSPL 589
Query: 123 HWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRV 179
H AA+ + E ++ L E+ +++ D+ T L A +G+ E V +L +GA +
Sbjct: 590 HLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALI 646
Score = 56.6 bits (135), Expect = 2e-08
Identities = 38/120 (31%), Positives = 55/120 (45%), Gaps = 4/120 (3%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVN---ALDGYNRTALHYAAEKDEA-CVEVLLEYGANP 111
PLH A D + LL++ G + +D Y +T L A CV +LLE G+
Sbjct: 655 PLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTA 714
Query: 112 NALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILL 171
+A D T LH A +C+ ALL+ A V D+ TP+ A+ G+ + LL
Sbjct: 715 DAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLL 774
Score = 55.8 bits (133), Expect = 4e-08
Identities = 46/142 (32%), Positives = 68/142 (47%), Gaps = 12/142 (8%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALD------GYNRTALHYAAEKD-EACVEVLLEYG 108
P+H A + LL+ + LD GY+ +H+A+ E C+E+LLE+
Sbjct: 757 PIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYS--PMHWASYTGHEDCLELLLEHS 814
Query: 109 ANPNALDGNRDTPLHWAAFKNNAECVRALLES-GAS-VNALDYNNDTPLSWAAMKGNLES 166
+ L+GN TPLH A N LL + GA VN+ D TPL AA N+
Sbjct: 815 PF-SYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSG 873
Query: 167 VSILLDYGAEVRVINLIGQTPI 188
+ +LL + AEV + G+T +
Sbjct: 874 LRMLLQHQAEVNATDHTGRTAL 895
Score = 55.5 bits (132), Expect = 5e-08
Identities = 61/230 (26%), Positives = 93/230 (40%), Gaps = 63/230 (27%)
Query: 39 DLIRGGADVNCTHGT-LKPLHCACMVSD-ADCVELLLEKGAEVNALDGYNRTALHYAAEK 96
+L+ GA+VN + PLH A + ++ A C+ELL+ GA+VN ++ LH AA
Sbjct: 257 ELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIH 316
Query: 97 DEAC-VEVLLEYGANPNALDGNRDTPLHWAA-----------FKNNA------------- 131
++L++ G+ + D +TPLH AA N A
Sbjct: 317 GRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPL 376
Query: 132 ---------ECVRALLESGA------------------SVNALDYNNDTPLSWAAMKGNL 164
+C R LL SG +N D T L AA GN+
Sbjct: 377 HLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNV 436
Query: 165 ESVSILLDYGAEVRVINLIGQTPI---------SRLVALLVRGLGTEKED 205
E +++LL GA++R + G+TP+ V L+ G G + D
Sbjct: 437 ECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEAD 486
Score = 45.8 bits (107), Expect = 4e-05
Identities = 27/73 (36%), Positives = 38/73 (52%)
Query: 121 PLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVI 180
PL A F + E VR+LL ++N LD TPL AA G++ + +LL GA V
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 181 NLIGQTPISRLVA 193
+ + TP+ R A
Sbjct: 71 DTLWLTPLHRAAA 83
>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
Length = 305
Score = 81.6 bits (200), Expect = 7e-16
Identities = 55/155 (35%), Positives = 78/155 (50%), Gaps = 4/155 (2%)
Query: 37 VEDLIRGGADVNCTHGTLK--PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA 94
++ + G D N H L LH AC+ + V LL GA V+A D +RT + +A
Sbjct: 127 IDKYLTDGGDPNA-HDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWAC 185
Query: 95 EKDEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDT 153
+ + LL GA NA D TPLH A + +C+ L+E GA +NA D DT
Sbjct: 186 RGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDT 245
Query: 154 PLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
L A G+ +++ +LL YGAE+ V N TP+
Sbjct: 246 ALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPV 280
Score = 72.4 bits (176), Expect = 4e-13
Identities = 40/99 (40%), Positives = 56/99 (56%)
Query: 90 LHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDY 149
L AAE E ++ L G +PNA D T LHWA K +++ V LL +GA+V+A D
Sbjct: 116 LKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDL 175
Query: 150 NNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
+ TP+ WA G+L + LL+ GA V + IG TP+
Sbjct: 176 LDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPL 214
Score = 57.8 bits (138), Expect = 1e-08
Identities = 41/125 (32%), Positives = 60/125 (48%), Gaps = 1/125 (0%)
Query: 69 VELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAF 127
++ L G + NA D +RTALH+A K + V LL GA +A D TP+ WA
Sbjct: 127 IDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACR 186
Query: 128 KNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTP 187
+ ++ LL GA VNA D TPL A + + + L++ GA + + G T
Sbjct: 187 GGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTA 246
Query: 188 ISRLV 192
+ V
Sbjct: 247 LHEAV 251
Score = 53.9 bits (128), Expect = 2e-07
Identities = 36/104 (34%), Positives = 52/104 (50%), Gaps = 1/104 (0%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAE-KDEACVEVLLEYGANPNAL 114
P+ AC ++ LL +GA VNA D T LH A + C+E L+E GA+ NA
Sbjct: 180 PVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQ 239
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWA 158
D DT LH A + + ++ LL GA + + + TP+ A
Sbjct: 240 DKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 80.9 bits (198), Expect = 1e-15
Identities = 48/125 (38%), Positives = 68/125 (54%), Gaps = 1/125 (0%)
Query: 69 VELLLEKGAEVNALDGYNRTALHYAAEKDE-ACVEVLLEYGANPNALDGNRDTPLHWAAF 127
V+LLL GA+VN D RT L AA + V+ LL GA+ +D T L WA
Sbjct: 1083 VDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACL 1142
Query: 128 KNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTP 187
K + VR+L+++GA+ + D N TPL AA G+ E V L+D+GA + ++ G P
Sbjct: 1143 KGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRP 1202
Query: 188 ISRLV 192
+ R V
Sbjct: 1203 LDRAV 1207
Score = 65.9 bits (159), Expect = 4e-11
Identities = 50/143 (34%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
Query: 37 VEDLIRGGADVNCTHGTLK-PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAE 95
V+ L+ GADVN + PL A V+ LL +GA + +D TAL +A
Sbjct: 1083 VDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACL 1142
Query: 96 KDE-ACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTP 154
K + V L++ GA + D N TPL AAF +AE V+ L++ GA + +DY+ P
Sbjct: 1143 KGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRP 1202
Query: 155 LSWAAMKGNLESVSILLDYGAEV 177
L A N V LL GA++
Sbjct: 1203 LDRAVGCRNTSVVVTLLKKGAKI 1225
Score = 51.6 bits (122), Expect = 8e-07
Identities = 46/152 (30%), Positives = 70/152 (46%), Gaps = 13/152 (8%)
Query: 50 THGTLKPLHCACMVSDADCVELLLE---------KGAEVNALDG-YNRTALHYAAEKD-- 97
+H + L A + + V LL+ + A++N+ D + TAL AA +
Sbjct: 988 SHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKL 1047
Query: 98 EACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSW 157
E C +LLE GA + PL + + + V LL GA VN D TPL
Sbjct: 1048 EVC-RLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMM 1106
Query: 158 AAMKGNLESVSILLDYGAEVRVINLIGQTPIS 189
AA +G+L +V LL GA + +++ G T +S
Sbjct: 1107 AASEGHLGTVDFLLAQGASIALMDKEGLTALS 1138
Score = 48.9 bits (115), Expect = 5e-06
Identities = 56/179 (31%), Positives = 79/179 (44%), Gaps = 15/179 (8%)
Query: 8 IMQSIQSKYSLSERLIRTIAAIRSFPHDNVED---LIRGGADVNCTHGTLKPLHCACMVS 64
I+Q + YS +E L +A++R+ N++ LI GGA++N L C+ S
Sbjct: 835 ILQGLWISYS-TEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQS 893
Query: 65 D---ADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLL-EYGANPNALDGNRDT 120
+ V LLLE GA V+A T L YAA + VLL + A + LD N
Sbjct: 894 HLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQC 953
Query: 121 PLHWAAFKNNAECVRALLE-------SGASVNALDYNNDTPLSWAAMKGNLESVSILLD 172
L AA + + E V+ L++ V + L AA G E VS LLD
Sbjct: 954 ALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLD 1012
Score = 33.5 bits (75), Expect = 0.22
Identities = 22/54 (40%), Positives = 30/54 (55%)
Query: 132 ECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQ 185
E V LLE GA+V+A + TPL +AA G L V +L A+V ++ GQ
Sbjct: 899 EMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQ 952
Score = 30.8 bits (68), Expect = 1.4
Identities = 32/108 (29%), Positives = 49/108 (45%), Gaps = 16/108 (14%)
Query: 130 NAECVRALLESGASVNALD--YNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTP 187
N + R L+ GA++N NN L + G E V++LL++GA V + G TP
Sbjct: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
Query: 188 IS--------RLVALLVRGLG----TEKEDSCFELLHRAV-GHFELRK 222
+ +V LL + +K C L+H A+ GH E+ K
Sbjct: 922 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQC-ALVHAALRGHLEVVK 968
>gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1
[Homo sapiens]
Length = 294
Score = 80.1 bits (196), Expect = 2e-15
Identities = 73/253 (28%), Positives = 105/253 (41%), Gaps = 45/253 (17%)
Query: 37 VEDLIRGGADVN-CTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAE 95
V+ L++ GA VN T PL AC+ DCV LLL+ GA V + + +H AA
Sbjct: 85 VKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQP-ESDLASPIHEAAR 143
Query: 96 KDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTP 154
+ CV L+ YG N + + TPL+ A CV+ LLESGA VN D+P
Sbjct: 144 RGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQ-GKGQDSP 202
Query: 155 LSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVALLVRGLGTEKEDSCFELLHRA 214
L A + E +L+D+GA+ + N G+ P+
Sbjct: 203 LHAVARTASEELACLLMDFGADTQAKNAEGKRPV-------------------------- 236
Query: 215 VGHFELRKNGTMPREVARDPQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGL 274
E+ +L + P +L L R +R+ G+Q K L
Sbjct: 237 --------------ELVPPESPLAQLFLEREGPPSLMQLCRLRIRKCFGIQQHHKITK-L 281
Query: 275 PLPASLKEYLLLL 287
LP LK++LL L
Sbjct: 282 VLPEDLKQFLLHL 294
Score = 52.8 bits (125), Expect = 4e-07
Identities = 38/122 (31%), Positives = 57/122 (46%), Gaps = 2/122 (1%)
Query: 35 DNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA 94
D V L++ GA V P+H A +CV L+ G ++ + T L+ A
Sbjct: 116 DCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLAC 175
Query: 95 EKDE-ACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDT 153
E + ACV+ LLE GA+ N G +D+PLH A + E L++ GA A +
Sbjct: 176 ENQQRACVKKLLESGADVNQGKG-QDSPLHAVARTASEELACLLMDFGADTQAKNAEGKR 234
Query: 154 PL 155
P+
Sbjct: 235 PV 236
Score = 49.3 bits (116), Expect = 4e-06
Identities = 26/75 (34%), Positives = 42/75 (56%)
Query: 104 LLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGN 163
L+ G N + + +PLH A + CV+ LL+ GA VN + + TPL A + G+
Sbjct: 55 LISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGS 114
Query: 164 LESVSILLDYGAEVR 178
+ V++LL +GA V+
Sbjct: 115 WDCVNLLLQHGASVQ 129
Score = 47.0 bits (110), Expect = 2e-05
Identities = 36/123 (29%), Positives = 55/123 (44%), Gaps = 12/123 (9%)
Query: 109 ANPNALDGNRD-TPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESV 167
+NP D D +P+H AA + +R L+ G +VN + ++ +PL A + G+L V
Sbjct: 26 SNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCV 85
Query: 168 SILLDYGAEVRVINLIGQTPISRLVA---------LLVRGLGTEKEDSCFELLHRAV--G 216
ILL +GA+V + TP+ LL G + E +H A G
Sbjct: 86 KILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRG 145
Query: 217 HFE 219
H E
Sbjct: 146 HVE 148
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 80.1 bits (196), Expect = 2e-15
Identities = 62/175 (35%), Positives = 85/175 (48%), Gaps = 14/175 (8%)
Query: 57 LHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEK-DEACVEVLLEYGANPNALD 115
LH A D LLLEK A VN +D RT +H A + E V +LL G + +
Sbjct: 508 LHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG 567
Query: 116 GNRDTPLHWAAFKNNAECVRALLES-GASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ PLH+AA++ + V+ L + G SVNA + TPL AA +G+ IL+D
Sbjct: 568 KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLC 627
Query: 175 AEVRVINLIGQTPI---------SRLVALLVRGLGTEKEDS-CFELLHRAV--GH 217
++V V +L+ QTP+ S LL RG G E S + LH A GH
Sbjct: 628 SDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGH 682
Score = 71.6 bits (174), Expect = 7e-13
Identities = 51/135 (37%), Positives = 67/135 (49%), Gaps = 2/135 (1%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEK-DEACVEVLLEYGANPNAL 114
PLH A VELLL + VNA D TALH+AA+ DE+ +LLE A+ N +
Sbjct: 474 PLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEV 533
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDY- 173
D TP+H A VR LL G V+ + PL +AA +G+L V +L
Sbjct: 534 DFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQP 593
Query: 174 GAEVRVINLIGQTPI 188
G V L G+TP+
Sbjct: 594 GVSVNAQTLDGRTPL 608
Score = 65.9 bits (159), Expect = 4e-11
Identities = 44/122 (36%), Positives = 58/122 (47%), Gaps = 1/122 (0%)
Query: 57 LHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKD-EACVEVLLEYGANPNALD 115
LH A +C + LL A N + T LH A E+ VE+LL + NA D
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
Query: 116 GNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGA 175
++ T LH+AA + R LLE ASVN +D+ TP+ A G V ILL G
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561
Query: 176 EV 177
+V
Sbjct: 562 DV 563
Score = 60.5 bits (145), Expect = 2e-09
Identities = 43/121 (35%), Positives = 58/121 (47%), Gaps = 11/121 (9%)
Query: 69 VELLLEKGAEVNALDGYNRTALHYAAEK-DEACVEVLLEYGANPNALDGNRDTPLHWAAF 127
V+L L+ GA + LH A E E C + LL ANPN + TPLH A
Sbjct: 431 VDLALDSGASL----------LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVE 480
Query: 128 KNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTP 187
+ V LL SVNA D + T L +AA G+ S +LL+ A V ++ G+TP
Sbjct: 481 RRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTP 540
Query: 188 I 188
+
Sbjct: 541 M 541
Score = 50.4 bits (119), Expect = 2e-06
Identities = 43/137 (31%), Positives = 61/137 (44%), Gaps = 5/137 (3%)
Query: 56 PLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE-ACVEVLLEYGANPNAL 114
PLH A +L++ ++VN +T LH AAE + +LL GA A+
Sbjct: 607 PLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAM 666
Query: 115 DGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYG 174
+ T LH AA + V+ L+E A V A N T L AA G+ E V L+
Sbjct: 667 TSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV--- 723
Query: 175 AEVRVINLIGQTPISRL 191
VI+L + +S L
Sbjct: 724 -SADVIDLFDEQGLSAL 739
Score = 42.0 bits (97), Expect = 6e-04
Identities = 35/106 (33%), Positives = 46/106 (43%)
Query: 40 LIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA 99
L RG T LH A V+LL+E+ A+V A N+TALH AA +
Sbjct: 657 LHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHS 716
Query: 100 CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVN 145
V L + D + LH AA +A+ V LL GA +N
Sbjct: 717 EVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
>gi|22208964 ankyrin repeat and SOCS box-containing protein 4
isoform b [Homo sapiens]
Length = 349
Score = 80.1 bits (196), Expect = 2e-15
Identities = 64/220 (29%), Positives = 106/220 (48%), Gaps = 22/220 (10%)
Query: 40 LIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE- 98
L+ A +NC PLH AC +++ DCV++L ++GA++N TALH+
Sbjct: 94 LLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSI 153
Query: 99 ACVEVLLEYGANPNALDGNRD--TPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLS 156
C + L+ GAN N N+D TPLH AA +E V +E GA V++++ + +TPL+
Sbjct: 154 LCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLA 213
Query: 157 WA---AMKGNLESVS--------ILLDYGAEVRVINLIGQTPISRLV-----ALLVRGLG 200
A A++ + S +LLDY AEV + ++P+ + L+ L
Sbjct: 214 IAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLE 273
Query: 201 TEKEDSCFELLHRAVGHFELRKNGTMPREVARDPQLCEKL 240
E + ++ A + L+ P A P++C +L
Sbjct: 274 AGAEANLMDINGCAAIQYVLKVTSVRP---AAQPEICYQL 310
Score = 64.7 bits (156), Expect = 9e-11
Identities = 43/136 (31%), Positives = 69/136 (50%), Gaps = 4/136 (2%)
Query: 57 LHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALD 115
LH + + +C+ +LL+ A +N +T LH A E CV++L + GA N
Sbjct: 79 LHLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAKLNCYS 137
Query: 116 GNRDTPLHWAAFKNNAECVRALLESGASVNALDYNND--TPLSWAAMKGNLESVSILLDY 173
+ T LH+ ++ C + L+ GA+VN N D TPL AA G E V+ +++
Sbjct: 138 LSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEH 197
Query: 174 GAEVRVINLIGQTPIS 189
GA V +N +TP++
Sbjct: 198 GAIVDSVNAHMETPLA 213
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,814,459
Number of Sequences: 37866
Number of extensions: 460791
Number of successful extensions: 4380
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 342
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 947
Number of HSP's gapped (non-prelim): 1719
length of query: 288
length of database: 18,247,518
effective HSP length: 101
effective length of query: 187
effective length of database: 14,423,052
effective search space: 2697110724
effective search space used: 2697110724
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.