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Search of human proteins with 4557617
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557617 growth arrest-specific 6 isoform 1 precursor [Homo
sapiens]
(678 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557617 growth arrest-specific 6 isoform 1 precursor [Homo sa... 1402 0.0
gi|221316735 growth arrest-specific 6 isoform 2 [Homo sapiens] 813 0.0
gi|221316738 growth arrest-specific 6 isoform 3 [Homo sapiens] 761 0.0
gi|192447438 protein S, alpha preproprotein [Homo sapiens] 588 e-168
gi|169218228 PREDICTED: similar to growth arrest-specific 6 [Hom... 203 5e-52
gi|110347437 latent transforming growth factor beta binding prot... 134 2e-31
gi|110347412 latent transforming growth factor beta binding prot... 134 2e-31
gi|110347431 latent transforming growth factor beta binding prot... 134 2e-31
gi|10190748 CEGP1 protein [Homo sapiens] 130 5e-30
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 129 9e-30
gi|19743803 fibulin 5 precursor [Homo sapiens] 124 3e-28
gi|86788132 EGF-containing fibulin-like extracellular matrix pro... 124 4e-28
gi|86788015 EGF-containing fibulin-like extracellular matrix pro... 124 4e-28
gi|9665262 EGF-containing fibulin-like extracellular matrix prot... 124 4e-28
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens] 123 5e-28
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens] 122 8e-28
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens] 122 8e-28
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 122 1e-27
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 122 1e-27
gi|34734066 fibulin 1 isoform D [Homo sapiens] 122 1e-27
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 122 1e-27
gi|194328809 latent transforming growth factor beta binding prot... 122 1e-27
gi|18497288 latent transforming growth factor beta binding prote... 122 1e-27
gi|66346695 fibrillin 2 precursor [Homo sapiens] 121 2e-27
gi|46249414 latent transforming growth factor beta binding prote... 120 3e-27
gi|46249412 latent transforming growth factor beta binding prote... 120 3e-27
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 120 3e-27
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 120 4e-27
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 120 4e-27
gi|24430141 fibrillin 1 precursor [Homo sapiens] 120 5e-27
>gi|4557617 growth arrest-specific 6 isoform 1 precursor [Homo
sapiens]
Length = 678
Score = 1402 bits (3628), Expect = 0.0
Identities = 678/678 (100%), Positives = 678/678 (100%)
Query: 1 MAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGH 60
MAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGH
Sbjct: 1 MAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGH 60
Query: 61 LERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQC 120
LERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQC
Sbjct: 61 LERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQC 120
Query: 121 TPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHC 180
TPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHC
Sbjct: 121 TPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHC 180
Query: 181 SCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVD 240
SCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVD
Sbjct: 181 SCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVD 240
Query: 241 ECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRM 300
ECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRM
Sbjct: 241 ECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRM 300
Query: 301 FSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLR 360
FSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLR
Sbjct: 301 FSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLR 360
Query: 361 YNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLN 420
YNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLN
Sbjct: 361 YNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLN 420
Query: 421 LTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFY 480
LTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFY
Sbjct: 421 LTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFY 480
Query: 481 PGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALV 540
PGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALV
Sbjct: 481 PGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALV 540
Query: 541 DYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVS 600
DYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVS
Sbjct: 541 DYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVS 600
Query: 601 AAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAY 660
AAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAY
Sbjct: 601 AAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAY 660
Query: 661 KHSDITAHSCPPVEPAAA 678
KHSDITAHSCPPVEPAAA
Sbjct: 661 KHSDITAHSCPPVEPAAA 678
>gi|221316735 growth arrest-specific 6 isoform 2 [Homo sapiens]
Length = 405
Score = 813 bits (2101), Expect = 0.0
Identities = 405/405 (100%), Positives = 405/405 (100%)
Query: 274 MDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGI 333
MDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGI
Sbjct: 1 MDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGI 60
Query: 334 LLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVI 393
LLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVI
Sbjct: 61 LLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVI 120
Query: 394 KVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNG 453
KVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNG
Sbjct: 121 KVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNG 180
Query: 454 EDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHI 513
EDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHI
Sbjct: 181 EDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHI 240
Query: 514 RPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQ 573
RPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQ
Sbjct: 241 RPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQ 300
Query: 574 EHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTS 633
EHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTS
Sbjct: 301 EHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTS 360
Query: 634 APVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA 678
APVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA
Sbjct: 361 APVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA 405
>gi|221316738 growth arrest-specific 6 isoform 3 [Homo sapiens]
Length = 379
Score = 761 bits (1964), Expect = 0.0
Identities = 379/379 (100%), Positives = 379/379 (100%)
Query: 300 MFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQL 359
MFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQL
Sbjct: 1 MFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQL 60
Query: 360 RYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHL 419
RYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHL
Sbjct: 61 RYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHL 120
Query: 420 NLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSF 479
NLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSF
Sbjct: 121 NLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSF 180
Query: 480 YPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVAL 539
YPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVAL
Sbjct: 181 YPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVAL 240
Query: 540 VDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEV 599
VDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEV
Sbjct: 241 VDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEV 300
Query: 600 SAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAA 659
SAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAA
Sbjct: 301 SAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAA 360
Query: 660 YKHSDITAHSCPPVEPAAA 678
YKHSDITAHSCPPVEPAAA
Sbjct: 361 YKHSDITAHSCPPVEPAAA 379
>gi|192447438 protein S, alpha preproprotein [Homo sapiens]
Length = 676
Score = 588 bits (1515), Expect = e-168
Identities = 297/671 (44%), Positives = 423/671 (63%), Gaps = 28/671 (4%)
Query: 18 LLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEARE 77
L LLL + A L ++A+Q L R+RRA + EE KQG+LEREC+EELC++EEARE
Sbjct: 12 LACLLLVLPVSEANFLSKQQASQVL-VRKRRANSLLEETKQGNLERECIEELCNKEEARE 70
Query: 78 VFENDPETDYFYPRYLDCINKY------GSPYTKNS--GFATCVQNLPDQCTPNPCDRKG 129
VFENDPETDYFYP+YL C+ + + + N+ +CV +PDQC+P PC+ G
Sbjct: 71 VFENDPETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLRSCVNAIPDQCSPLPCNEDG 130
Query: 130 TQACQDLMGNFFCLCKAGWGGRLCDKDVNEC---SQENGGCLQICHNKPGSFHCSCHSGF 186
+C+D +F C CK GW G C+ D+NEC S NGGC QIC N PGS+HCSC +GF
Sbjct: 131 YMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGF 190
Query: 187 ELSSDGRTCQDIDECA-DSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQG 245
+ S+ + C+D+DEC+ CG A CKN+PG + C C EG+ Y+ + K+C D+DEC +
Sbjct: 191 VMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRYNLKSKSCEDIDECSEN 250
Query: 246 RCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRMFSGTP 305
C Q+CVN PG YTC+CDG+ G KL+QD +CE + C+P ++ + LYL F+G
Sbjct: 251 MCAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKYELLYLAEQFAGV- 309
Query: 306 VIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVG 365
V+ L+F+ + +R AEFDFRT+D EG++L+A S W+++ALR G++E+QL+
Sbjct: 310 VLYLKFRLPEISRFSAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTS 369
Query: 366 RVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGG 425
++T+ G VIN+G+W +SVEEL ++ IK+ ++AVM I G LF+PE GL + G
Sbjct: 370 KITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGLLETKVYFAG 429
Query: 426 IPFH-EKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFYPGSG 484
P E +L++PINPRLDGC+RSWN + + I+E ++ C E+GS+YPGSG
Sbjct: 430 FPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVEKGSYYPGSG 489
Query: 485 FAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHS 544
A + +DY +V + W V V +IRP+ TGV+ AL + + VP +V+LVD S
Sbjct: 490 IAQFHIDYN----NVSSAEGWHVNVTLNIRPSTGTGVMLALVSGN-NTVPFAVSLVDSTS 544
Query: 545 TKKLKKQLVVLAVEHTAL-ALMEIKVC-DGQEHVVTVSLRDGEATLEVDGTRGQSEVSAA 602
K Q ++L+VE+T + + + +C D Q H + R LE+ +S
Sbjct: 545 E---KSQDILLSVENTVIYRIQALSLCSDQQSH---LEFRVNRNNLELSTPLKIETISHE 598
Query: 603 QLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKH 662
LQ +LAVL++ +++ V T+ GGLPDVP ++ PV AFY GCM + +N LDLDEA KH
Sbjct: 599 DLQRQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFYNGCMEVNINGVQLDLDEAISKH 658
Query: 663 SDITAHSCPPV 673
+DI AHSCP V
Sbjct: 659 NDIRAHSCPSV 669
>gi|169218228 PREDICTED: similar to growth arrest-specific 6 [Homo
sapiens]
Length = 100
Score = 203 bits (516), Expect = 5e-52
Identities = 94/96 (97%), Positives = 95/96 (98%)
Query: 401 MKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQE 460
MKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQE
Sbjct: 1 MKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQE 60
Query: 461 TVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTP 496
TVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYM+ P
Sbjct: 61 TVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMQAP 96
>gi|110347437 latent transforming growth factor beta binding protein
4 isoform c [Homo sapiens]
Length = 1557
Score = 134 bits (338), Expect = 2e-31
Identities = 75/176 (42%), Positives = 97/176 (55%), Gaps = 9/176 (5%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGC-LQICHNKPG 176
D+CT +P G AC++L G+F C+C AG+ G C++DV+EC+QE C C N G
Sbjct: 606 DECTQSP-GLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAG 664
Query: 177 SFHCSCHSGFELSSDGRTCQDIDECADS-EACGEARCKNLPGSYSCLCDEGFAYSSQEKA 235
SFHC+C +GF G CQD+DECA S C RC+N GS+ C+C GF ++
Sbjct: 665 SFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSE 724
Query: 236 CRDVDECLQGRC--EQVCVNSPGSYTCH-CDGRGGLKLSQ--DMDTCED-ILPCVP 285
C DVDEC Q CVNSPGS+ C C L + D+D C PC P
Sbjct: 725 CEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGP 780
Score = 114 bits (284), Expect = 4e-25
Identities = 71/178 (39%), Positives = 94/178 (52%), Gaps = 28/178 (15%)
Query: 118 DQC--TPNPCDRKGTQACQDLMGNFFCLCKAGW--GGRLCD-KDVNECSQENGGC-LQIC 171
D+C P PC C++ G+F C+C G+ G R + DV+EC + C L C
Sbjct: 522 DECRRVPPPC---APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRC 578
Query: 172 HNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEA-CGEARCKNLPGSYSCLCDEGFAYS 230
N PGSF C C +G++ + G +CQD+DEC S CG CKNLPGS+ C+C GF S
Sbjct: 579 ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGS 638
Query: 231 SQEKACRDVDECLQ-------GRCEQVCVNSPGSYTCHCD----GRGGLKLSQDMDTC 277
+ E+ DVDEC Q GRC+ N+ GS+ C C RG QD+D C
Sbjct: 639 ACEE---DVDECAQEPPPCGPGRCD----NTAGSFHCACPAGFRSRGPGAPCQDVDEC 689
Score = 105 bits (261), Expect = 2e-22
Identities = 78/222 (35%), Positives = 107/222 (48%), Gaps = 32/222 (14%)
Query: 84 ETDYFYPRYLDCINKYGS-------PYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDL 136
E D+ +P + +C+N GS Y A+C+ D+C+ + G C +
Sbjct: 817 EGDFCFP-HGECLNTDGSFACTCAPGYRPGPRGASCLD--VDECSEEDLCQSGI--CTNT 871
Query: 137 MGNFFCLCKAGW--GGRLCD-KDVNECSQENGGCL---QICHNKPGSFHC--SCHSGFEL 188
G+F C+C G G L DV+EC +E G L Q C N PGS+ C C G+
Sbjct: 872 DGSFECICPPGHRAGPDLASCLDVDEC-RERGPALCGSQRCENSPGSYRCVRDCDPGYHA 930
Query: 189 SSDGRTCQDIDECAD--SEACGEARCKNLPGSYSCL--CDEGFAYSSQEKACRDVDECLQ 244
+G TC D+DEC + E CG RC+N PGSY C CD G+ + C+DVDEC
Sbjct: 931 GPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRN 988
Query: 245 GR---CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
VC N PGS+ C CD G + ++D C D+ C
Sbjct: 989 RSFCGAHAVCQNLPGSFQCLCD--QGYEGARDGRHCVDVNEC 1028
Score = 102 bits (254), Expect = 1e-21
Identities = 63/159 (39%), Positives = 89/159 (55%), Gaps = 17/159 (10%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCL--CKAGWGGR---LCDKDVNECSQENGGCL---Q 169
D+C G+Q C++ G++ C+ C G+ CD DV+EC QE G + Q
Sbjct: 896 DECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCD-DVDEC-QEYGPEICGAQ 953
Query: 170 ICHNKPGSFHCS--CHSGFELSSDGRTCQDIDECADSEACG-EARCKNLPGSYSCLCDEG 226
C N PGS+ C+ C G++ + G CQD+DEC + CG A C+NLPGS+ CLCD+G
Sbjct: 954 RCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQG 1012
Query: 227 FAYSSQEKACRDVDEC--LQGRC-EQVCVNSPGSYTCHC 262
+ + + C DV+EC LQG C +C N GS+ C C
Sbjct: 1013 YEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVC 1051
Score = 100 bits (248), Expect = 6e-21
Identities = 64/181 (35%), Positives = 85/181 (46%), Gaps = 22/181 (12%)
Query: 118 DQCTPN--PCDRKGTQACQDLMGNFFCLCKAGW---GGRLCD-KDVNECSQ-----ENGG 166
D+C+ PC G C + G+F C C G+ GR DVNEC + +G
Sbjct: 769 DECSSGAPPCGPHGH--CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGE 826
Query: 167 CLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEG 226
CL N GSF C+C G+ G +C D+DEC++ + C C N GS+ C+C G
Sbjct: 827 CL----NTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPG 882
Query: 227 FAYSSQEKACRDVDECLQ---GRC-EQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILP 282
+C DVDEC + C Q C NSPGSY C D G + TC+D+
Sbjct: 883 HRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPE-GTCDDVDE 941
Query: 283 C 283
C
Sbjct: 942 C 942
Score = 92.0 bits (227), Expect = 2e-18
Identities = 49/147 (33%), Positives = 71/147 (48%), Gaps = 20/147 (13%)
Query: 145 KAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECAD- 203
++G +C ++ C C ++P + C+C SGF LS G C D+DEC
Sbjct: 474 ESGPSSGMCQRNPQVCGPGR------CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRV 527
Query: 204 SEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQ-------GRCEQVCVNSPG 256
C RC+N PGS+ C+C GF + C DVDEC + GRCE N+PG
Sbjct: 528 PPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCE----NTPG 583
Query: 257 SYTCHCDGRGGLKLSQDMDTCEDILPC 283
S+ C C G + + +C+D+ C
Sbjct: 584 SFLCVCP--AGYQAAPHGASCQDVDEC 608
Score = 61.2 bits (147), Expect = 3e-09
Identities = 30/77 (38%), Positives = 40/77 (51%), Gaps = 8/77 (10%)
Query: 164 NGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEA----CGEARCKNLPGSY 219
NG C+++ P F C C G+ L C DI+EC ++EA C ARC N GS+
Sbjct: 1478 NGRCVRV----PEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSF 1533
Query: 220 SCLCDEGFAYSSQEKAC 236
C+C GFA + Q C
Sbjct: 1534 RCICRPGFAPTHQPHHC 1550
Score = 57.0 bits (136), Expect = 6e-08
Identities = 31/80 (38%), Positives = 39/80 (48%), Gaps = 5/80 (6%)
Query: 189 SSDGRTCQDIDECA--DSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECL--Q 244
S D +D+DEC + C C N YSC C G+ Y +Q C D DEC +
Sbjct: 1178 SGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEE 1237
Query: 245 GRCE-QVCVNSPGSYTCHCD 263
CE CVN+ GSY C C+
Sbjct: 1238 PACEGGRCVNTVGSYHCTCE 1257
Score = 56.2 bits (134), Expect = 1e-07
Identities = 28/85 (32%), Positives = 39/85 (45%), Gaps = 3/85 (3%)
Query: 155 KDVNECSQENGGCLQ--ICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSE-ACGEAR 211
+DV+EC + +C N + C C +G+ + C D DECAD E AC R
Sbjct: 1185 RDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGR 1244
Query: 212 CKNLPGSYSCLCDEGFAYSSQEKAC 236
C N GSY C C+ ++ C
Sbjct: 1245 CVNTVGSYHCTCEPPLVLDGSQRRC 1269
Score = 55.8 bits (133), Expect = 1e-07
Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 21/136 (15%)
Query: 103 YTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAG--WGGRLCDKDVNEC 160
Y+ SGF C + L +P TQ C AG WG C C
Sbjct: 213 YSDASGFGYCFRELRGGECASPLPGLRTQEV--------CCRGAGLAWGVHDCQL----C 260
Query: 161 SQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYS 220
S+ G ++ + P C +GFE + +C+D+DECA C C N G Y+
Sbjct: 261 SERLGNSERV--SAPDG---PCPTGFERVNG--SCEDVDECATGGRCQHGECANTRGGYT 313
Query: 221 CLCDEGFAYSSQEKAC 236
C+C +GF S +C
Sbjct: 314 CVCPDGFLLDSSRSSC 329
Score = 49.7 bits (117), Expect = 9e-06
Identities = 20/72 (27%), Positives = 34/72 (47%), Gaps = 6/72 (8%)
Query: 197 DIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQV------ 250
+ +EC + C RC +P ++C C +G+ AC D++EC +
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1525
Query: 251 CVNSPGSYTCHC 262
C+N+ GS+ C C
Sbjct: 1526 CLNTDGSFRCIC 1537
Score = 37.0 bits (84), Expect = 0.060
Identities = 22/57 (38%), Positives = 26/57 (45%), Gaps = 6/57 (10%)
Query: 223 CDEGFAYSSQEKACRDVDECLQG-RCEQ-VCVNSPGSYTCHCDGRGGLKLSQDMDTC 277
C GF +C DVDEC G RC+ C N+ G YTC C G L +C
Sbjct: 277 CPTGF--ERVNGSCEDVDECATGGRCQHGECANTRGGYTCVCP--DGFLLDSSRSSC 329
>gi|110347412 latent transforming growth factor beta binding protein
4 isoform b [Homo sapiens]
Length = 1587
Score = 134 bits (338), Expect = 2e-31
Identities = 75/176 (42%), Positives = 97/176 (55%), Gaps = 9/176 (5%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGC-LQICHNKPG 176
D+CT +P G AC++L G+F C+C AG+ G C++DV+EC+QE C C N G
Sbjct: 636 DECTQSP-GLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAG 694
Query: 177 SFHCSCHSGFELSSDGRTCQDIDECADS-EACGEARCKNLPGSYSCLCDEGFAYSSQEKA 235
SFHC+C +GF G CQD+DECA S C RC+N GS+ C+C GF ++
Sbjct: 695 SFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSE 754
Query: 236 CRDVDECLQGRC--EQVCVNSPGSYTCH-CDGRGGLKLSQ--DMDTCED-ILPCVP 285
C DVDEC Q CVNSPGS+ C C L + D+D C PC P
Sbjct: 755 CEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGP 810
Score = 114 bits (284), Expect = 4e-25
Identities = 71/178 (39%), Positives = 94/178 (52%), Gaps = 28/178 (15%)
Query: 118 DQC--TPNPCDRKGTQACQDLMGNFFCLCKAGW--GGRLCD-KDVNECSQENGGC-LQIC 171
D+C P PC C++ G+F C+C G+ G R + DV+EC + C L C
Sbjct: 552 DECRRVPPPC---APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRC 608
Query: 172 HNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEA-CGEARCKNLPGSYSCLCDEGFAYS 230
N PGSF C C +G++ + G +CQD+DEC S CG CKNLPGS+ C+C GF S
Sbjct: 609 ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGS 668
Query: 231 SQEKACRDVDECLQ-------GRCEQVCVNSPGSYTCHCD----GRGGLKLSQDMDTC 277
+ E+ DVDEC Q GRC+ N+ GS+ C C RG QD+D C
Sbjct: 669 ACEE---DVDECAQEPPPCGPGRCD----NTAGSFHCACPAGFRSRGPGAPCQDVDEC 719
Score = 105 bits (261), Expect = 2e-22
Identities = 78/222 (35%), Positives = 107/222 (48%), Gaps = 32/222 (14%)
Query: 84 ETDYFYPRYLDCINKYGS-------PYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDL 136
E D+ +P + +C+N GS Y A+C+ D+C+ + G C +
Sbjct: 847 EGDFCFP-HGECLNTDGSFACTCAPGYRPGPRGASCLD--VDECSEEDLCQSGI--CTNT 901
Query: 137 MGNFFCLCKAGW--GGRLCD-KDVNECSQENGGCL---QICHNKPGSFHC--SCHSGFEL 188
G+F C+C G G L DV+EC +E G L Q C N PGS+ C C G+
Sbjct: 902 DGSFECICPPGHRAGPDLASCLDVDEC-RERGPALCGSQRCENSPGSYRCVRDCDPGYHA 960
Query: 189 SSDGRTCQDIDECAD--SEACGEARCKNLPGSYSCL--CDEGFAYSSQEKACRDVDECLQ 244
+G TC D+DEC + E CG RC+N PGSY C CD G+ + C+DVDEC
Sbjct: 961 GPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRN 1018
Query: 245 GR---CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
VC N PGS+ C CD G + ++D C D+ C
Sbjct: 1019 RSFCGAHAVCQNLPGSFQCLCD--QGYEGARDGRHCVDVNEC 1058
Score = 102 bits (254), Expect = 1e-21
Identities = 63/159 (39%), Positives = 89/159 (55%), Gaps = 17/159 (10%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCL--CKAGWGGR---LCDKDVNECSQENGGCL---Q 169
D+C G+Q C++ G++ C+ C G+ CD DV+EC QE G + Q
Sbjct: 926 DECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCD-DVDEC-QEYGPEICGAQ 983
Query: 170 ICHNKPGSFHCS--CHSGFELSSDGRTCQDIDECADSEACG-EARCKNLPGSYSCLCDEG 226
C N PGS+ C+ C G++ + G CQD+DEC + CG A C+NLPGS+ CLCD+G
Sbjct: 984 RCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQG 1042
Query: 227 FAYSSQEKACRDVDEC--LQGRC-EQVCVNSPGSYTCHC 262
+ + + C DV+EC LQG C +C N GS+ C C
Sbjct: 1043 YEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVC 1081
Score = 100 bits (248), Expect = 6e-21
Identities = 64/181 (35%), Positives = 85/181 (46%), Gaps = 22/181 (12%)
Query: 118 DQCTPN--PCDRKGTQACQDLMGNFFCLCKAGW---GGRLCD-KDVNECSQ-----ENGG 166
D+C+ PC G C + G+F C C G+ GR DVNEC + +G
Sbjct: 799 DECSSGAPPCGPHGH--CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGE 856
Query: 167 CLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEG 226
CL N GSF C+C G+ G +C D+DEC++ + C C N GS+ C+C G
Sbjct: 857 CL----NTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPG 912
Query: 227 FAYSSQEKACRDVDECLQ---GRC-EQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILP 282
+C DVDEC + C Q C NSPGSY C D G + TC+D+
Sbjct: 913 HRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPE-GTCDDVDE 971
Query: 283 C 283
C
Sbjct: 972 C 972
Score = 92.0 bits (227), Expect = 2e-18
Identities = 49/147 (33%), Positives = 71/147 (48%), Gaps = 20/147 (13%)
Query: 145 KAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECAD- 203
++G +C ++ C C ++P + C+C SGF LS G C D+DEC
Sbjct: 504 ESGPSSGMCQRNPQVCGPGR------CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRV 557
Query: 204 SEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQ-------GRCEQVCVNSPG 256
C RC+N PGS+ C+C GF + C DVDEC + GRCE N+PG
Sbjct: 558 PPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCE----NTPG 613
Query: 257 SYTCHCDGRGGLKLSQDMDTCEDILPC 283
S+ C C G + + +C+D+ C
Sbjct: 614 SFLCVCP--AGYQAAPHGASCQDVDEC 638
Score = 61.2 bits (147), Expect = 3e-09
Identities = 30/77 (38%), Positives = 40/77 (51%), Gaps = 8/77 (10%)
Query: 164 NGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEA----CGEARCKNLPGSY 219
NG C+++ P F C C G+ L C DI+EC ++EA C ARC N GS+
Sbjct: 1508 NGRCVRV----PEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSF 1563
Query: 220 SCLCDEGFAYSSQEKAC 236
C+C GFA + Q C
Sbjct: 1564 RCICRPGFAPTHQPHHC 1580
Score = 57.0 bits (136), Expect = 6e-08
Identities = 31/80 (38%), Positives = 39/80 (48%), Gaps = 5/80 (6%)
Query: 189 SSDGRTCQDIDECA--DSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECL--Q 244
S D +D+DEC + C C N YSC C G+ Y +Q C D DEC +
Sbjct: 1208 SGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEE 1267
Query: 245 GRCE-QVCVNSPGSYTCHCD 263
CE CVN+ GSY C C+
Sbjct: 1268 PACEGGRCVNTVGSYHCTCE 1287
Score = 56.2 bits (134), Expect = 1e-07
Identities = 28/85 (32%), Positives = 39/85 (45%), Gaps = 3/85 (3%)
Query: 155 KDVNECSQENGGCLQ--ICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSE-ACGEAR 211
+DV+EC + +C N + C C +G+ + C D DECAD E AC R
Sbjct: 1215 RDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGR 1274
Query: 212 CKNLPGSYSCLCDEGFAYSSQEKAC 236
C N GSY C C+ ++ C
Sbjct: 1275 CVNTVGSYHCTCEPPLVLDGSQRRC 1299
Score = 55.8 bits (133), Expect = 1e-07
Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 21/136 (15%)
Query: 103 YTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAG--WGGRLCDKDVNEC 160
Y+ SGF C + L +P TQ C AG WG C C
Sbjct: 243 YSDASGFGYCFRELRGGECASPLPGLRTQEV--------CCRGAGLAWGVHDCQL----C 290
Query: 161 SQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYS 220
S+ G ++ + P C +GFE + +C+D+DECA C C N G Y+
Sbjct: 291 SERLGNSERV--SAPDG---PCPTGFERVNG--SCEDVDECATGGRCQHGECANTRGGYT 343
Query: 221 CLCDEGFAYSSQEKAC 236
C+C +GF S +C
Sbjct: 344 CVCPDGFLLDSSRSSC 359
Score = 49.7 bits (117), Expect = 9e-06
Identities = 20/72 (27%), Positives = 34/72 (47%), Gaps = 6/72 (8%)
Query: 197 DIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQV------ 250
+ +EC + C RC +P ++C C +G+ AC D++EC +
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1555
Query: 251 CVNSPGSYTCHC 262
C+N+ GS+ C C
Sbjct: 1556 CLNTDGSFRCIC 1567
Score = 37.0 bits (84), Expect = 0.060
Identities = 22/57 (38%), Positives = 26/57 (45%), Gaps = 6/57 (10%)
Query: 223 CDEGFAYSSQEKACRDVDECLQG-RCEQ-VCVNSPGSYTCHCDGRGGLKLSQDMDTC 277
C GF +C DVDEC G RC+ C N+ G YTC C G L +C
Sbjct: 307 CPTGF--ERVNGSCEDVDECATGGRCQHGECANTRGGYTCVCP--DGFLLDSSRSSC 359
>gi|110347431 latent transforming growth factor beta binding protein
4 isoform a [Homo sapiens]
Length = 1624
Score = 134 bits (338), Expect = 2e-31
Identities = 75/176 (42%), Positives = 97/176 (55%), Gaps = 9/176 (5%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGC-LQICHNKPG 176
D+CT +P G AC++L G+F C+C AG+ G C++DV+EC+QE C C N G
Sbjct: 673 DECTQSP-GLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAG 731
Query: 177 SFHCSCHSGFELSSDGRTCQDIDECADS-EACGEARCKNLPGSYSCLCDEGFAYSSQEKA 235
SFHC+C +GF G CQD+DECA S C RC+N GS+ C+C GF ++
Sbjct: 732 SFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSE 791
Query: 236 CRDVDECLQGRC--EQVCVNSPGSYTCH-CDGRGGLKLSQ--DMDTCED-ILPCVP 285
C DVDEC Q CVNSPGS+ C C L + D+D C PC P
Sbjct: 792 CEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGP 847
Score = 114 bits (284), Expect = 4e-25
Identities = 71/178 (39%), Positives = 94/178 (52%), Gaps = 28/178 (15%)
Query: 118 DQC--TPNPCDRKGTQACQDLMGNFFCLCKAGW--GGRLCD-KDVNECSQENGGC-LQIC 171
D+C P PC C++ G+F C+C G+ G R + DV+EC + C L C
Sbjct: 589 DECRRVPPPC---APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRC 645
Query: 172 HNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEA-CGEARCKNLPGSYSCLCDEGFAYS 230
N PGSF C C +G++ + G +CQD+DEC S CG CKNLPGS+ C+C GF S
Sbjct: 646 ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGS 705
Query: 231 SQEKACRDVDECLQ-------GRCEQVCVNSPGSYTCHCD----GRGGLKLSQDMDTC 277
+ E+ DVDEC Q GRC+ N+ GS+ C C RG QD+D C
Sbjct: 706 ACEE---DVDECAQEPPPCGPGRCD----NTAGSFHCACPAGFRSRGPGAPCQDVDEC 756
Score = 105 bits (261), Expect = 2e-22
Identities = 78/222 (35%), Positives = 107/222 (48%), Gaps = 32/222 (14%)
Query: 84 ETDYFYPRYLDCINKYGS-------PYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDL 136
E D+ +P + +C+N GS Y A+C+ D+C+ + G C +
Sbjct: 884 EGDFCFP-HGECLNTDGSFACTCAPGYRPGPRGASCLD--VDECSEEDLCQSGI--CTNT 938
Query: 137 MGNFFCLCKAGW--GGRLCD-KDVNECSQENGGCL---QICHNKPGSFHC--SCHSGFEL 188
G+F C+C G G L DV+EC +E G L Q C N PGS+ C C G+
Sbjct: 939 DGSFECICPPGHRAGPDLASCLDVDEC-RERGPALCGSQRCENSPGSYRCVRDCDPGYHA 997
Query: 189 SSDGRTCQDIDECAD--SEACGEARCKNLPGSYSCL--CDEGFAYSSQEKACRDVDECLQ 244
+G TC D+DEC + E CG RC+N PGSY C CD G+ + C+DVDEC
Sbjct: 998 GPEG-TCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRN 1055
Query: 245 GR---CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
VC N PGS+ C CD G + ++D C D+ C
Sbjct: 1056 RSFCGAHAVCQNLPGSFQCLCD--QGYEGARDGRHCVDVNEC 1095
Score = 102 bits (254), Expect = 1e-21
Identities = 63/159 (39%), Positives = 89/159 (55%), Gaps = 17/159 (10%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCL--CKAGWGGR---LCDKDVNECSQENGGCL---Q 169
D+C G+Q C++ G++ C+ C G+ CD DV+EC QE G + Q
Sbjct: 963 DECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCD-DVDEC-QEYGPEICGAQ 1020
Query: 170 ICHNKPGSFHCS--CHSGFELSSDGRTCQDIDECADSEACG-EARCKNLPGSYSCLCDEG 226
C N PGS+ C+ C G++ + G CQD+DEC + CG A C+NLPGS+ CLCD+G
Sbjct: 1021 RCENTPGSYRCTPACDPGYQ-PTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQG 1079
Query: 227 FAYSSQEKACRDVDEC--LQGRC-EQVCVNSPGSYTCHC 262
+ + + C DV+EC LQG C +C N GS+ C C
Sbjct: 1080 YEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVC 1118
Score = 100 bits (248), Expect = 6e-21
Identities = 64/181 (35%), Positives = 85/181 (46%), Gaps = 22/181 (12%)
Query: 118 DQCTPN--PCDRKGTQACQDLMGNFFCLCKAGW---GGRLCD-KDVNECSQ-----ENGG 166
D+C+ PC G C + G+F C C G+ GR DVNEC + +G
Sbjct: 836 DECSSGAPPCGPHGH--CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGE 893
Query: 167 CLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEG 226
CL N GSF C+C G+ G +C D+DEC++ + C C N GS+ C+C G
Sbjct: 894 CL----NTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPG 949
Query: 227 FAYSSQEKACRDVDECLQ---GRC-EQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILP 282
+C DVDEC + C Q C NSPGSY C D G + TC+D+
Sbjct: 950 HRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPE-GTCDDVDE 1008
Query: 283 C 283
C
Sbjct: 1009 C 1009
Score = 92.0 bits (227), Expect = 2e-18
Identities = 49/147 (33%), Positives = 71/147 (48%), Gaps = 20/147 (13%)
Query: 145 KAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECAD- 203
++G +C ++ C C ++P + C+C SGF LS G C D+DEC
Sbjct: 541 ESGPSSGMCQRNPQVCGPGR------CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRV 594
Query: 204 SEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQ-------GRCEQVCVNSPG 256
C RC+N PGS+ C+C GF + C DVDEC + GRCE N+PG
Sbjct: 595 PPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCE----NTPG 650
Query: 257 SYTCHCDGRGGLKLSQDMDTCEDILPC 283
S+ C C G + + +C+D+ C
Sbjct: 651 SFLCVCP--AGYQAAPHGASCQDVDEC 675
Score = 61.2 bits (147), Expect = 3e-09
Identities = 30/77 (38%), Positives = 40/77 (51%), Gaps = 8/77 (10%)
Query: 164 NGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEA----CGEARCKNLPGSY 219
NG C+++ P F C C G+ L C DI+EC ++EA C ARC N GS+
Sbjct: 1545 NGRCVRV----PEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSF 1600
Query: 220 SCLCDEGFAYSSQEKAC 236
C+C GFA + Q C
Sbjct: 1601 RCICRPGFAPTHQPHHC 1617
Score = 57.0 bits (136), Expect = 6e-08
Identities = 31/80 (38%), Positives = 39/80 (48%), Gaps = 5/80 (6%)
Query: 189 SSDGRTCQDIDECA--DSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECL--Q 244
S D +D+DEC + C C N YSC C G+ Y +Q C D DEC +
Sbjct: 1245 SGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEE 1304
Query: 245 GRCE-QVCVNSPGSYTCHCD 263
CE CVN+ GSY C C+
Sbjct: 1305 PACEGGRCVNTVGSYHCTCE 1324
Score = 56.2 bits (134), Expect = 1e-07
Identities = 28/85 (32%), Positives = 39/85 (45%), Gaps = 3/85 (3%)
Query: 155 KDVNECSQENGGCLQ--ICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSE-ACGEAR 211
+DV+EC + +C N + C C +G+ + C D DECAD E AC R
Sbjct: 1252 RDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGR 1311
Query: 212 CKNLPGSYSCLCDEGFAYSSQEKAC 236
C N GSY C C+ ++ C
Sbjct: 1312 CVNTVGSYHCTCEPPLVLDGSQRRC 1336
Score = 55.8 bits (133), Expect = 1e-07
Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 21/136 (15%)
Query: 103 YTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAG--WGGRLCDKDVNEC 160
Y+ SGF C + L +P TQ C AG WG C C
Sbjct: 280 YSDASGFGYCFRELRGGECASPLPGLRTQEV--------CCRGAGLAWGVHDCQL----C 327
Query: 161 SQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYS 220
S+ G ++ + P C +GFE + +C+D+DECA C C N G Y+
Sbjct: 328 SERLGNSERV--SAPDG---PCPTGFERVNG--SCEDVDECATGGRCQHGECANTRGGYT 380
Query: 221 CLCDEGFAYSSQEKAC 236
C+C +GF S +C
Sbjct: 381 CVCPDGFLLDSSRSSC 396
Score = 49.7 bits (117), Expect = 9e-06
Identities = 20/72 (27%), Positives = 34/72 (47%), Gaps = 6/72 (8%)
Query: 197 DIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQV------ 250
+ +EC + C RC +P ++C C +G+ AC D++EC +
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1592
Query: 251 CVNSPGSYTCHC 262
C+N+ GS+ C C
Sbjct: 1593 CLNTDGSFRCIC 1604
Score = 37.0 bits (84), Expect = 0.060
Identities = 22/57 (38%), Positives = 26/57 (45%), Gaps = 6/57 (10%)
Query: 223 CDEGFAYSSQEKACRDVDECLQG-RCEQ-VCVNSPGSYTCHCDGRGGLKLSQDMDTC 277
C GF +C DVDEC G RC+ C N+ G YTC C G L +C
Sbjct: 344 CPTGF--ERVNGSCEDVDECATGGRCQHGECANTRGGYTCVCP--DGFLLDSSRSSC 396
>gi|10190748 CEGP1 protein [Homo sapiens]
Length = 999
Score = 130 bits (326), Expect = 5e-30
Identities = 74/196 (37%), Positives = 102/196 (52%), Gaps = 18/196 (9%)
Query: 116 LPDQCTPNP--CDRKGTQACQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQ 169
L + C N CDR C+D C C G+ G+ C KD++EC NGGC
Sbjct: 282 LMETCAVNNGGCDR----TCKDTSTGVHCSCPVGFTLQLDGKTC-KDIDECQTRNGGCDH 336
Query: 170 ICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAY 229
C N GSF C C GF+L +D ++CQD+DEC+ C + C N PG+++C C+ G+
Sbjct: 337 FCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHS-CINHPGTFACACNRGYTL 395
Query: 230 SSQEKACRDVDECL--QGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFS 287
C D +EC G C+QVCVN+ GSY C C G KL + C ++ +P S
Sbjct: 396 YGFTH-CGDTNECSINNGGCQQVCVNTVGSYECQC--HPGYKLHWNKKDCVEVKGLLPTS 452
Query: 288 VAKSVKSLYLGRMFSG 303
V+ V SL+ G+ G
Sbjct: 453 VSPRV-SLHCGKSGGG 467
Score = 116 bits (290), Expect = 8e-26
Identities = 67/186 (36%), Positives = 93/186 (50%), Gaps = 15/186 (8%)
Query: 108 GFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGG--RLCDKDVNECSQE-N 164
G A Q D+C D CQ+ ++ C CK G+ G R C+ D++EC E N
Sbjct: 37 GRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCE-DIDECGNELN 95
Query: 165 GGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCD 224
GGC+ C N PG++ C+C GF L+ DG C D+DEC ++ + C N+ GSY C C
Sbjct: 96 GGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCK 155
Query: 225 EGFAYSSQEKACRDVDE----CL--QGRCEQVCVNSP-GSYTCHCDGRGGLKLSQDMDTC 277
EGF S + C E C+ C +C +P GS C C R G +L+++ C
Sbjct: 156 EGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACEC--RPGFELAKNQRDC 213
Query: 278 EDILPC 283
IL C
Sbjct: 214 --ILTC 217
Score = 85.9 bits (211), Expect = 1e-16
Identities = 52/205 (25%), Positives = 84/205 (40%), Gaps = 34/205 (16%)
Query: 111 TCVQNLPDQCTPNPCDRKGTQACQDL-MGNFFCLCKAGWGGRLCDKD-VNECSQENGGCL 168
TC+ + + D + C++ G+ C C+ G+ +D + C+ NGGC
Sbjct: 166 TCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQ 225
Query: 169 QICHNKPGSFHCSCHSGFELSSDGRTCQD----------------------------IDE 200
C + CSCH +++ +DGR+C + ++
Sbjct: 226 HSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMET 285
Query: 201 CADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDEC--LQGRCEQVCVNSPGSY 258
CA + + CK+ C C GF K C+D+DEC G C+ C N GS+
Sbjct: 286 CAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSF 345
Query: 259 TCHCDGRGGLKLSQDMDTCEDILPC 283
C C + G KL D +C+D+ C
Sbjct: 346 DCGC--KKGFKLLTDEKSCQDVDEC 368
Score = 46.2 bits (108), Expect = 1e-04
Identities = 36/125 (28%), Positives = 43/125 (34%), Gaps = 52/125 (41%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW---GGRLCDKDVNECSQENGGCLQICHNK 174
D+C+ DR +C + G F C C G+ G C D NECS NGGC Q+C N
Sbjct: 366 DECS---LDRTCDHSCINHPGTFACACNRGYTLYGFTHCG-DTNECSINNGGCQQVCVNT 421
Query: 175 PGSFHCSCH---------------------------------------------SGFELS 189
GS+ C CH SG LS
Sbjct: 422 VGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFLRCHSGIHLS 481
Query: 190 SDGRT 194
SD T
Sbjct: 482 SDVTT 486
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 129 bits (324), Expect = 9e-30
Identities = 71/168 (42%), Positives = 86/168 (51%), Gaps = 19/168 (11%)
Query: 103 YTKNSGFATCVQNLPDQCTPNP--CDRKGTQACQDLMGNFFCLCKAGW----GGRLCDKD 156
Y +S TC++ C N CDR C+D C C G+ G+ C KD
Sbjct: 232 YALHSDGRTCIET----CAVNNGGCDR----TCKDTATGVRCSCPVGFTLQPDGKTC-KD 282
Query: 157 VNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLP 216
+NEC NGGC C N GSF C C G++L +D RTCQDIDEC+ C C N P
Sbjct: 283 INECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHI-CINSP 341
Query: 217 GSYSCLCDEGFAYSSQEKACRDVDECLQ--GRCEQVCVNSPGSYTCHC 262
GS+ CLC G+ C DVDEC G C+Q CVN+ GSY C C
Sbjct: 342 GSFQCLCHRGYILYGTTH-CGDVDECSMSNGSCDQGCVNTKGSYECVC 388
Score = 109 bits (273), Expect = 7e-24
Identities = 59/171 (34%), Positives = 85/171 (49%), Gaps = 14/171 (8%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGG--RLCDKDVNECSQE--NGGCLQICHN 173
D+C+ D CQ+ ++ CLCK G+ G + C+ D++EC + NGGC+ C N
Sbjct: 35 DECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCE-DIDECENDYYNGGCVHECIN 93
Query: 174 KPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQE 233
PG++ C+C GF L+ DG C D+DEC D+ + C N GSY C C GF S +
Sbjct: 94 IPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQ 153
Query: 234 KAC----RDVDECL--QGRCEQVCVNSP-GSYTCHCDGRGGLKLSQDMDTC 277
C + C+ C +C +P G C C R G L+Q+ C
Sbjct: 154 HTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDC--RPGFDLAQNQKDC 202
Score = 108 bits (270), Expect = 2e-23
Identities = 55/155 (35%), Positives = 81/155 (52%), Gaps = 13/155 (8%)
Query: 132 ACQDLMGNFFCLCKAGWG----GRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFE 187
+C+D C C + GR C + C+ NGGC + C + CSC GF
Sbjct: 216 SCEDTDTGPTCGCHQKYALHSDGRTC---IETCAVNNGGCDRTCKDTATGVRCSCPVGFT 272
Query: 188 LSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDEC-LQGR 246
L DG+TC+DI+EC + + C+N GS+ C C +G+ + E+ C+D+DEC +
Sbjct: 273 LQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERT 332
Query: 247 CEQVCVNSPGSYTCHCDGRG----GLKLSQDMDTC 277
C+ +C+NSPGS+ C C RG G D+D C
Sbjct: 333 CDHICINSPGSFQCLCH-RGYILYGTTHCGDVDEC 366
Score = 103 bits (256), Expect = 7e-22
Identities = 66/200 (33%), Positives = 89/200 (44%), Gaps = 15/200 (7%)
Query: 95 CINKYGSPYTK-NSGFA------TCVQNLPDQCTPNPCDRKGTQACQDL-MGNFFCLCKA 146
C+N GS + +SGF TC+ + D C++ G C C+
Sbjct: 132 CVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRP 191
Query: 147 GWGGRLCDKDVN-ECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSE 205
G+ KD C+ NGGC C + C CH + L SDGRTC I+ CA +
Sbjct: 192 GFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNN 249
Query: 206 ACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECL--QGRCEQVCVNSPGSYTCHCD 263
+ CK+ C C GF K C+D++ECL G C+ C N+ GS+ C C
Sbjct: 250 GGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGC- 308
Query: 264 GRGGLKLSQDMDTCEDILPC 283
R G KL D TC+DI C
Sbjct: 309 -RKGYKLLTDERTCQDIDEC 327
Score = 84.3 bits (207), Expect = 3e-16
Identities = 61/213 (28%), Positives = 83/213 (38%), Gaps = 47/213 (22%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQICHN 173
D+C + + C ++ GN+ C C G+ G C DV+EC NGGC QIC N
Sbjct: 76 DECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNC-LDVDECQDNNGGCQQICVN 134
Query: 174 KPGSFHCSCHSGFELSSDGRTC----QDIDECADSEACGEARCKNLP-GSYSCLCDEGFA 228
GS+ C CHSGF LS + TC + C + + C+ P G +C C GF
Sbjct: 135 AMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFD 194
Query: 229 YSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHC--------DGRG-------------- 266
+ +K C G C+ C ++ TC C DGR
Sbjct: 195 LAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDR 254
Query: 267 ---------------GLKLSQDMDTCEDILPCV 284
G L D TC+DI C+
Sbjct: 255 TCKDTATGVRCSCPVGFTLQPDGKTCKDINECL 287
Score = 60.1 bits (144), Expect = 7e-09
Identities = 37/110 (33%), Positives = 51/110 (46%), Gaps = 10/110 (9%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW---GGRLCDKDVNECSQENGGCLQICHNK 174
D+C+ +R C + G+F CLC G+ G C DV+ECS NG C Q C N
Sbjct: 325 DECS---FERTCDHICINSPGSFQCLCHRGYILYGTTHCG-DVDECSMSNGSCDQGCVNT 380
Query: 175 PGSFHCSCHSGFELSSDGRTCQDIDEC---ADSEACGEARCKNLPGSYSC 221
GS+ C C G L +G+ C + +C A + + C G SC
Sbjct: 381 KGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESC 430
>gi|19743803 fibulin 5 precursor [Homo sapiens]
Length = 448
Score = 124 bits (311), Expect = 3e-28
Identities = 65/169 (38%), Positives = 87/169 (51%), Gaps = 8/169 (4%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAG-WGGRLCDKDVNECSQENGGCLQICHNKPG 176
D+C + TQ C + G + C C G W D++EC G C Q+C N PG
Sbjct: 129 DECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRY--GYCQQLCANVPG 186
Query: 177 SFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKAC 236
S+ C+C+ GF L+ DGR+CQD++ECA C + C N GS+ C CD G+ C
Sbjct: 187 SYSCTCNPGFTLNEDGRSCQDVNECATENPCVQT-CVNTYGSFICRCDPGYELEEDGVHC 245
Query: 237 RDVDECLQGR--CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
D+DEC C+ CVN PG+Y C C G L D +C+DI C
Sbjct: 246 SDMDECSFSEFLCQHECVNQPGTYFCSCP--PGYILLDDNRSCQDINEC 292
Score = 111 bits (277), Expect = 2e-24
Identities = 57/151 (37%), Positives = 79/151 (52%), Gaps = 14/151 (9%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQICHN 173
D+C C Q C ++ G++ C C G+ GR C +DVNEC+ EN C+Q C N
Sbjct: 170 DECRYGYCQ----QLCANVPGSYSCTCNPGFTLNEDGRSC-QDVNECATENP-CVQTCVN 223
Query: 174 KPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQE 233
GSF C C G+EL DG C D+DEC+ SE + C N PG+Y C C G+
Sbjct: 224 TYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDN 283
Query: 234 KACRDVDECLQG----RCEQVCVNSPGSYTC 260
++C+D++EC +Q C N G + C
Sbjct: 284 RSCQDINECEHRNHTCNLQQTCYNLQGGFKC 314
Score = 100 bits (250), Expect = 3e-21
Identities = 53/131 (40%), Positives = 73/131 (55%), Gaps = 9/131 (6%)
Query: 156 DVNECSQENGGC--LQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCK 213
DV+EC+ ++ C QIC N G + CSC G+ L C DIDEC + C
Sbjct: 127 DVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEG--QCLDIDECRYGYC--QQLCA 182
Query: 214 NLPGSYSCLCDEGFAYSSQEKACRDVDECL-QGRCEQVCVNSPGSYTCHCDGRGGLKLSQ 272
N+PGSYSC C+ GF + ++C+DV+EC + C Q CVN+ GS+ C CD G +L +
Sbjct: 183 NVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCD--PGYELEE 240
Query: 273 DMDTCEDILPC 283
D C D+ C
Sbjct: 241 DGVHCSDMDEC 251
Score = 86.3 bits (212), Expect = 9e-17
Identities = 42/104 (40%), Positives = 60/104 (57%), Gaps = 7/104 (6%)
Query: 182 CHSGFELSSDGRTCQDIDECA-DSEACGEAR-CKNLPGSYSCLCDEGFAYSSQEKACRDV 239
C G+++ + C D+DECA DS C + C N G Y+C C +G Y E C D+
Sbjct: 113 CRFGYQMDESNQ-CVDVDECATDSHQCNPTQICINTEGGYTCSCTDG--YWLLEGQCLDI 169
Query: 240 DECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
DEC G C+Q+C N PGSY+C C+ G L++D +C+D+ C
Sbjct: 170 DECRYGYCQQLCANVPGSYSCTCN--PGFTLNEDGRSCQDVNEC 211
Score = 57.0 bits (136), Expect = 6e-08
Identities = 45/161 (27%), Positives = 57/161 (35%), Gaps = 52/161 (32%)
Query: 168 LQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECAD-SEAC-GEARCKNLPGSYSC---- 221
L +C PG+ C +GF+L C DIDEC EAC G+ C N G Y C
Sbjct: 13 LALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRT 72
Query: 222 ---------------------------------------LCDEGFAYSSQEKACRDVDEC 242
+C G+ + C DVDEC
Sbjct: 73 NPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGY-QMDESNQCVDVDEC 131
Query: 243 L----QGRCEQVCVNSPGSYTCHCDGRGGLKLSQ--DMDTC 277
Q Q+C+N+ G YTC C L Q D+D C
Sbjct: 132 ATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDEC 172
>gi|86788132 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
Length = 493
Score = 124 bits (310), Expect = 4e-28
Identities = 65/170 (38%), Positives = 94/170 (55%), Gaps = 10/170 (5%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW--GGRLCDKDVNECSQENGGCLQICHNKP 175
D+CT + + Q C +L G+F C C G+ G C D++EC+ C Q C N P
Sbjct: 175 DECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQC-VDIDECTIP-PYCHQRCVNTP 232
Query: 176 GSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKA 235
GSF+C C GF+L+++ TC DI+EC S C + +C N+ GS+ C C++G+ SS
Sbjct: 233 GSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLN 291
Query: 236 CRDVDECLQGR--CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
C D+DEC C+ CVN PG ++C C + S+ TC+DI C
Sbjct: 292 CEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR---TCQDINEC 338
Score = 107 bits (266), Expect = 5e-23
Identities = 55/150 (36%), Positives = 82/150 (54%), Gaps = 11/150 (7%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW---GGRLCDKDVNECSQENGGCLQICHNK 174
D+CT P Q C + G+F+C C G+ D+NEC N C Q C+N
Sbjct: 216 DECTIPPYCH---QRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ-CAQQCYNI 271
Query: 175 PGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEK 234
GSF C C+ G+ELSSD C+DIDEC S + +C N PG +SC+C +G+ + +
Sbjct: 272 LGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQV-VRSR 330
Query: 235 ACRDVDEC---LQGRCEQVCVNSPGSYTCH 261
C+D++EC + R +++C N G + C+
Sbjct: 331 TCQDINECETTNECREDEMCWNYHGGFRCY 360
Score = 78.6 bits (192), Expect = 2e-14
Identities = 45/110 (40%), Positives = 61/110 (55%), Gaps = 8/110 (7%)
Query: 177 SFHCSCHSGFELSSDGRTCQDIDEC-ADSEAC-GEARCKNLPGSYSCLCDEGFAYSSQEK 234
S C +G+E S+ CQDIDEC A + C + C NL GS++C C G Y + +
Sbjct: 154 SHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPG--YQKRGE 210
Query: 235 ACRDVDEC-LQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
C D+DEC + C Q CVN+PGS+ C C G +L+ + TC DI C
Sbjct: 211 QCVDIDECTIPPYCHQRCVNTPGSFYCQCS--PGFQLAANNYTCVDINEC 258
Score = 33.9 bits (76), Expect = 0.51
Identities = 18/46 (39%), Positives = 24/46 (52%), Gaps = 2/46 (4%)
Query: 179 HCSCHSGFELSSDGRTCQDIDEC-ADSEAC-GEARCKNLPGSYSCL 222
+ C G+E + C+DIDEC +AC G +C N G Y CL
Sbjct: 26 YTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL 71
Score = 32.7 bits (73), Expect = 1.1
Identities = 14/42 (33%), Positives = 22/42 (52%), Gaps = 4/42 (9%)
Query: 223 CDEGFAYSSQEKACRDVDEC--LQGRCE--QVCVNSPGSYTC 260
C +G+ + + C+D+DEC + C+ CVN G Y C
Sbjct: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC 70
>gi|86788015 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
Length = 493
Score = 124 bits (310), Expect = 4e-28
Identities = 65/170 (38%), Positives = 94/170 (55%), Gaps = 10/170 (5%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW--GGRLCDKDVNECSQENGGCLQICHNKP 175
D+CT + + Q C +L G+F C C G+ G C D++EC+ C Q C N P
Sbjct: 175 DECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQC-VDIDECTIP-PYCHQRCVNTP 232
Query: 176 GSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKA 235
GSF+C C GF+L+++ TC DI+EC S C + +C N+ GS+ C C++G+ SS
Sbjct: 233 GSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLN 291
Query: 236 CRDVDECLQGR--CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
C D+DEC C+ CVN PG ++C C + S+ TC+DI C
Sbjct: 292 CEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR---TCQDINEC 338
Score = 107 bits (266), Expect = 5e-23
Identities = 55/150 (36%), Positives = 82/150 (54%), Gaps = 11/150 (7%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW---GGRLCDKDVNECSQENGGCLQICHNK 174
D+CT P Q C + G+F+C C G+ D+NEC N C Q C+N
Sbjct: 216 DECTIPPYCH---QRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ-CAQQCYNI 271
Query: 175 PGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEK 234
GSF C C+ G+ELSSD C+DIDEC S + +C N PG +SC+C +G+ + +
Sbjct: 272 LGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQV-VRSR 330
Query: 235 ACRDVDEC---LQGRCEQVCVNSPGSYTCH 261
C+D++EC + R +++C N G + C+
Sbjct: 331 TCQDINECETTNECREDEMCWNYHGGFRCY 360
Score = 78.6 bits (192), Expect = 2e-14
Identities = 45/110 (40%), Positives = 61/110 (55%), Gaps = 8/110 (7%)
Query: 177 SFHCSCHSGFELSSDGRTCQDIDEC-ADSEAC-GEARCKNLPGSYSCLCDEGFAYSSQEK 234
S C +G+E S+ CQDIDEC A + C + C NL GS++C C G Y + +
Sbjct: 154 SHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPG--YQKRGE 210
Query: 235 ACRDVDEC-LQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
C D+DEC + C Q CVN+PGS+ C C G +L+ + TC DI C
Sbjct: 211 QCVDIDECTIPPYCHQRCVNTPGSFYCQCS--PGFQLAANNYTCVDINEC 258
Score = 33.9 bits (76), Expect = 0.51
Identities = 18/46 (39%), Positives = 24/46 (52%), Gaps = 2/46 (4%)
Query: 179 HCSCHSGFELSSDGRTCQDIDEC-ADSEAC-GEARCKNLPGSYSCL 222
+ C G+E + C+DIDEC +AC G +C N G Y CL
Sbjct: 26 YTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL 71
Score = 32.7 bits (73), Expect = 1.1
Identities = 14/42 (33%), Positives = 22/42 (52%), Gaps = 4/42 (9%)
Query: 223 CDEGFAYSSQEKACRDVDEC--LQGRCE--QVCVNSPGSYTC 260
C +G+ + + C+D+DEC + C+ CVN G Y C
Sbjct: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC 70
>gi|9665262 EGF-containing fibulin-like extracellular matrix protein
1 precursor [Homo sapiens]
Length = 493
Score = 124 bits (310), Expect = 4e-28
Identities = 65/170 (38%), Positives = 94/170 (55%), Gaps = 10/170 (5%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW--GGRLCDKDVNECSQENGGCLQICHNKP 175
D+CT + + Q C +L G+F C C G+ G C D++EC+ C Q C N P
Sbjct: 175 DECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQC-VDIDECTIP-PYCHQRCVNTP 232
Query: 176 GSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKA 235
GSF+C C GF+L+++ TC DI+EC S C + +C N+ GS+ C C++G+ SS
Sbjct: 233 GSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLN 291
Query: 236 CRDVDECLQGR--CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
C D+DEC C+ CVN PG ++C C + S+ TC+DI C
Sbjct: 292 CEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR---TCQDINEC 338
Score = 107 bits (266), Expect = 5e-23
Identities = 55/150 (36%), Positives = 82/150 (54%), Gaps = 11/150 (7%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW---GGRLCDKDVNECSQENGGCLQICHNK 174
D+CT P Q C + G+F+C C G+ D+NEC N C Q C+N
Sbjct: 216 DECTIPPYCH---QRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ-CAQQCYNI 271
Query: 175 PGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEK 234
GSF C C+ G+ELSSD C+DIDEC S + +C N PG +SC+C +G+ + +
Sbjct: 272 LGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQV-VRSR 330
Query: 235 ACRDVDEC---LQGRCEQVCVNSPGSYTCH 261
C+D++EC + R +++C N G + C+
Sbjct: 331 TCQDINECETTNECREDEMCWNYHGGFRCY 360
Score = 78.6 bits (192), Expect = 2e-14
Identities = 45/110 (40%), Positives = 61/110 (55%), Gaps = 8/110 (7%)
Query: 177 SFHCSCHSGFELSSDGRTCQDIDEC-ADSEAC-GEARCKNLPGSYSCLCDEGFAYSSQEK 234
S C +G+E S+ CQDIDEC A + C + C NL GS++C C G Y + +
Sbjct: 154 SHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPG--YQKRGE 210
Query: 235 ACRDVDEC-LQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
C D+DEC + C Q CVN+PGS+ C C G +L+ + TC DI C
Sbjct: 211 QCVDIDECTIPPYCHQRCVNTPGSFYCQCS--PGFQLAANNYTCVDINEC 258
Score = 33.9 bits (76), Expect = 0.51
Identities = 18/46 (39%), Positives = 24/46 (52%), Gaps = 2/46 (4%)
Query: 179 HCSCHSGFELSSDGRTCQDIDEC-ADSEAC-GEARCKNLPGSYSCL 222
+ C G+E + C+DIDEC +AC G +C N G Y CL
Sbjct: 26 YTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL 71
Score = 32.7 bits (73), Expect = 1.1
Identities = 14/42 (33%), Positives = 22/42 (52%), Gaps = 4/42 (9%)
Query: 223 CDEGFAYSSQEKACRDVDEC--LQGRCE--QVCVNSPGSYTC 260
C +G+ + + C+D+DEC + C+ CVN G Y C
Sbjct: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC 70
>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
Length = 993
Score = 123 bits (309), Expect = 5e-28
Identities = 71/180 (39%), Positives = 88/180 (48%), Gaps = 18/180 (10%)
Query: 111 TCVQNLPDQCTPNP--CDRKGTQACQDLMGNFFCLCKAGW---GGRLCDKDVNECSQENG 165
TC++ C N CD K C D C C G+ R KD++EC NG
Sbjct: 235 TCIET----CAVNNGGCDSK----CHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNG 286
Query: 166 GCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDE 225
GC IC N GSF CSC G++L + R CQDIDEC+ C C N PGS+ CLC
Sbjct: 287 GCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHI-CVNTPGSFQCLCHR 345
Query: 226 GFAYSSQEKACRDVDECL--QGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
G+ C DVDEC +G C C+N+PGSY C C G +L + C + L C
Sbjct: 346 GYLLYGITH-CGDVDECSINRGGCRFGCINTPGSYQCTCPAGQG-RLHWNGKDCTEPLKC 403
Score = 114 bits (286), Expect = 2e-25
Identities = 60/171 (35%), Positives = 90/171 (52%), Gaps = 13/171 (7%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW--GGRLCDKDVNECSQE-NGGCLQICHNK 174
D+C + CQ+ ++ C+CK+G+ G+ C KDV+EC +E N GC+ C N
Sbjct: 31 DECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHC-KDVDECEREDNAGCVHDCVNI 89
Query: 175 PGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEK 234
PG++ C+C+ GF L+ DG C D+DECA+ + C N+ GSY C C EGF S +
Sbjct: 90 PGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQH 149
Query: 235 ACRDVDE----CLQGR--CEQVCVNSP-GSYTCHCDGRGGLKLSQDMDTCE 278
C E C+ C +C +P G C C R G +L+++ C+
Sbjct: 150 TCIQRPEEGMNCMNKNHGCAHICRETPKGGIACEC--RPGFELTKNQRDCK 198
Score = 108 bits (269), Expect = 2e-23
Identities = 52/133 (39%), Positives = 74/133 (55%), Gaps = 9/133 (6%)
Query: 150 GRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGE 209
G+ C + C+ NGGC CH+ HC+C GF L D +TC+DIDEC + +
Sbjct: 233 GKTC---IETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCD 289
Query: 210 ARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGR-CEQVCVNSPGSYTCHCDGRG-- 266
C+N GS+ C C +G+ E+ C+D+DEC R C+ +CVN+PGS+ C C RG
Sbjct: 290 HICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCH-RGYL 348
Query: 267 --GLKLSQDMDTC 277
G+ D+D C
Sbjct: 349 LYGITHCGDVDEC 361
Score = 94.7 bits (234), Expect = 2e-19
Identities = 57/200 (28%), Positives = 87/200 (43%), Gaps = 15/200 (7%)
Query: 95 CINKYGS-------PYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDL-MGNFFCLCKA 146
C+N GS + + TC+Q + + C++ G C C+
Sbjct: 127 CVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRP 186
Query: 147 GWGGRLCDKDVN-ECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSE 205
G+ +D C+ NGGC C + C CH F L +DG+TC I+ CA +
Sbjct: 187 GFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNN 244
Query: 206 ACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECL--QGRCEQVCVNSPGSYTCHCD 263
+++C + C C GF K C+D+DEC G C+ +C N+ GS+ C C
Sbjct: 245 GGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSC- 303
Query: 264 GRGGLKLSQDMDTCEDILPC 283
+ G KL + C+DI C
Sbjct: 304 -KKGYKLLINERNCQDIDEC 322
Score = 56.6 bits (135), Expect = 7e-08
Identities = 35/97 (36%), Positives = 49/97 (50%), Gaps = 8/97 (8%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW---GGRLCDKDVNECSQENGGCLQICHNK 174
D+C+ DR C + G+F CLC G+ G C DV+ECS GGC C N
Sbjct: 320 DECS---FDRTCDHICVNTPGSFQCLCHRGYLLYGITHCG-DVDECSINRGGCRFGCINT 375
Query: 175 PGSFHCSCHSG-FELSSDGRTCQDIDECADSEACGEA 210
PGS+ C+C +G L +G+ C + +C S +A
Sbjct: 376 PGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKA 412
Score = 41.2 bits (95), Expect = 0.003
Identities = 21/51 (41%), Positives = 29/51 (56%), Gaps = 6/51 (11%)
Query: 234 KACRDVDECLQG----RCEQVCVNSPGSYTCHCDG--RGGLKLSQDMDTCE 278
KA +DVDEC++G + +C N+P SY C C G K +D+D CE
Sbjct: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECE 75
>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
Length = 937
Score = 122 bits (307), Expect = 8e-28
Identities = 62/172 (36%), Positives = 87/172 (50%), Gaps = 10/172 (5%)
Query: 120 CTPNPC---DRKGTQACQDLMGNFFCLCKAGW---GGRLCDKDVNECSQENGGCLQICHN 173
CT + C + C ++ G++ C CK G+ + + + C+ E+ C Q+C N
Sbjct: 237 CTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVN 296
Query: 174 KPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQE 233
PGSF C C+SG+ L+ DG+ C +D CA E C N GSY C C EGFA + +
Sbjct: 297 VPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDK 356
Query: 234 KACRDVDECLQGR--CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
K C +D C C+ CVN+ SY+CHC G L+ D TC I C
Sbjct: 357 KTCTKIDYCASSNHGCQHECVNTDDSYSCHC--LKGFTLNPDKKTCRRINYC 406
Score = 103 bits (257), Expect = 5e-22
Identities = 53/151 (35%), Positives = 78/151 (51%), Gaps = 9/151 (5%)
Query: 133 CQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFEL 188
C ++ +++C C G+ G+ C + V+ C+Q++ GC Q+C N SF C C GF +
Sbjct: 417 CVNMEESYYCRCHRGYTLDPNGKTCSR-VDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLI 475
Query: 189 SSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQG--R 246
+ D +TC +D C S+ E C N+ S++C C EG S K C +D C G
Sbjct: 476 NEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHG 535
Query: 247 CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTC 277
CE CV+S S+ C C G L +D TC
Sbjct: 536 CEHSCVSSEDSFVCQC--FEGYILREDGKTC 564
Score = 100 bits (248), Expect = 6e-21
Identities = 62/183 (33%), Positives = 84/183 (45%), Gaps = 17/183 (9%)
Query: 103 YTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQ 162
YT + TC + D C D Q C + +F C C G+ L ++D+ CS+
Sbjct: 432 YTLDPNGKTCSR--VDHCAQQ--DHGCEQLCLNTEDSFVCQCSEGF---LINEDLKTCSR 484
Query: 163 ------ENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLP 216
+ GC C N SF C C G L SDG+TC +D CA + E C +
Sbjct: 485 VDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSE 544
Query: 217 GSYSCLCDEGFAYSSQEKACR--DVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDM 274
S+ C C EG+ K CR DV + + CE +CVNS SYTC C G +L++D
Sbjct: 545 DSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCEC--LEGFRLAEDG 602
Query: 275 DTC 277
C
Sbjct: 603 KRC 605
Score = 97.1 bits (240), Expect = 5e-20
Identities = 65/203 (32%), Positives = 89/203 (43%), Gaps = 20/203 (9%)
Query: 94 DCINKYGSPYTK-NSGFATCVQNLPDQCTPNPCD-----RKGTQ-ACQDLMGNFFCLCKA 146
+C+N GS + + GFA PD+ T D G Q C + ++ C C
Sbjct: 334 ECVNADGSYLCQCHEGFALN----PDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLK 389
Query: 147 GW----GGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECA 202
G+ + C + +N C+ GC C N S++C CH G+ L +G+TC +D CA
Sbjct: 390 GFTLNPDKKTCRR-INYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCA 448
Query: 203 DSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECL--QGRCEQVCVNSPGSYTC 260
+ E C N S+ C C EGF + K C VD CL CE CVN S+ C
Sbjct: 449 QQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFAC 508
Query: 261 HCDGRGGLKLSQDMDTCEDILPC 283
C G L D TC + C
Sbjct: 509 QCP--EGHVLRSDGKTCAKLDSC 529
Score = 91.3 bits (225), Expect = 3e-18
Identities = 52/153 (33%), Positives = 73/153 (47%), Gaps = 9/153 (5%)
Query: 132 ACQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFE 187
+C ++ +F C C G G+ C K ++ C+ + GC C + SF C C G+
Sbjct: 498 SCVNMDRSFACQCPEGHVLRSDGKTCAK-LDSCALGDHGCEHSCVSSEDSFVCQCFEGYI 556
Query: 188 LSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGR- 246
L DG+TC+ D C + E C N SY+C C EGF + K CR D C
Sbjct: 557 LREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHH 616
Query: 247 -CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCE 278
CE +CVN+ SY C C G L++D C+
Sbjct: 617 GCEHICVNNGNSYICKCS--EGFVLAEDGRRCK 647
Score = 71.2 bits (173), Expect = 3e-12
Identities = 42/126 (33%), Positives = 58/126 (46%), Gaps = 10/126 (7%)
Query: 132 ACQDLMGNFFCLCKAGW----GGRLCD-KDVNECSQENGGCLQICHNKPGSFHCSCHSGF 186
+C +F C C G+ G+ C KDV C + GC IC N S+ C C GF
Sbjct: 539 SCVSSEDSFVCQCFEGYILREDGKTCRRKDV--CQAIDHGCEHICVNSDDSYTCECLEGF 596
Query: 187 ELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGR 246
L+ DG+ C+ D C + E C N SY C C EGF + + C+ +C +G
Sbjct: 597 RLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCK---KCTEGP 653
Query: 247 CEQVCV 252
+ V V
Sbjct: 654 IDLVFV 659
>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
Length = 956
Score = 122 bits (307), Expect = 8e-28
Identities = 62/172 (36%), Positives = 87/172 (50%), Gaps = 10/172 (5%)
Query: 120 CTPNPC---DRKGTQACQDLMGNFFCLCKAGW---GGRLCDKDVNECSQENGGCLQICHN 173
CT + C + C ++ G++ C CK G+ + + + C+ E+ C Q+C N
Sbjct: 237 CTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVN 296
Query: 174 KPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQE 233
PGSF C C+SG+ L+ DG+ C +D CA E C N GSY C C EGFA + +
Sbjct: 297 VPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDK 356
Query: 234 KACRDVDECLQGR--CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
K C +D C C+ CVN+ SY+CHC G L+ D TC I C
Sbjct: 357 KTCTKIDYCASSNHGCQHECVNTDDSYSCHC--LKGFTLNPDKKTCRRINYC 406
Score = 103 bits (257), Expect = 5e-22
Identities = 53/151 (35%), Positives = 78/151 (51%), Gaps = 9/151 (5%)
Query: 133 CQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFEL 188
C ++ +++C C G+ G+ C + V+ C+Q++ GC Q+C N SF C C GF +
Sbjct: 417 CVNMEESYYCRCHRGYTLDPNGKTCSR-VDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLI 475
Query: 189 SSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQG--R 246
+ D +TC +D C S+ E C N+ S++C C EG S K C +D C G
Sbjct: 476 NEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHG 535
Query: 247 CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTC 277
CE CV+S S+ C C G L +D TC
Sbjct: 536 CEHSCVSSEDSFVCQC--FEGYILREDGKTC 564
Score = 100 bits (248), Expect = 6e-21
Identities = 62/183 (33%), Positives = 84/183 (45%), Gaps = 17/183 (9%)
Query: 103 YTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQ 162
YT + TC + D C D Q C + +F C C G+ L ++D+ CS+
Sbjct: 432 YTLDPNGKTCSR--VDHCAQQ--DHGCEQLCLNTEDSFVCQCSEGF---LINEDLKTCSR 484
Query: 163 ------ENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLP 216
+ GC C N SF C C G L SDG+TC +D CA + E C +
Sbjct: 485 VDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSE 544
Query: 217 GSYSCLCDEGFAYSSQEKACR--DVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDM 274
S+ C C EG+ K CR DV + + CE +CVNS SYTC C G +L++D
Sbjct: 545 DSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCEC--LEGFRLAEDG 602
Query: 275 DTC 277
C
Sbjct: 603 KRC 605
Score = 97.1 bits (240), Expect = 5e-20
Identities = 65/203 (32%), Positives = 89/203 (43%), Gaps = 20/203 (9%)
Query: 94 DCINKYGSPYTK-NSGFATCVQNLPDQCTPNPCD-----RKGTQ-ACQDLMGNFFCLCKA 146
+C+N GS + + GFA PD+ T D G Q C + ++ C C
Sbjct: 334 ECVNADGSYLCQCHEGFALN----PDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLK 389
Query: 147 GW----GGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECA 202
G+ + C + +N C+ GC C N S++C CH G+ L +G+TC +D CA
Sbjct: 390 GFTLNPDKKTCRR-INYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCA 448
Query: 203 DSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECL--QGRCEQVCVNSPGSYTC 260
+ E C N S+ C C EGF + K C VD CL CE CVN S+ C
Sbjct: 449 QQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFAC 508
Query: 261 HCDGRGGLKLSQDMDTCEDILPC 283
C G L D TC + C
Sbjct: 509 QCP--EGHVLRSDGKTCAKLDSC 529
Score = 91.3 bits (225), Expect = 3e-18
Identities = 52/153 (33%), Positives = 73/153 (47%), Gaps = 9/153 (5%)
Query: 132 ACQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFE 187
+C ++ +F C C G G+ C K ++ C+ + GC C + SF C C G+
Sbjct: 498 SCVNMDRSFACQCPEGHVLRSDGKTCAK-LDSCALGDHGCEHSCVSSEDSFVCQCFEGYI 556
Query: 188 LSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGR- 246
L DG+TC+ D C + E C N SY+C C EGF + K CR D C
Sbjct: 557 LREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHH 616
Query: 247 -CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCE 278
CE +CVN+ SY C C G L++D C+
Sbjct: 617 GCEHICVNNGNSYICKCS--EGFVLAEDGRRCK 647
Score = 71.2 bits (173), Expect = 3e-12
Identities = 42/126 (33%), Positives = 58/126 (46%), Gaps = 10/126 (7%)
Query: 132 ACQDLMGNFFCLCKAGW----GGRLCD-KDVNECSQENGGCLQICHNKPGSFHCSCHSGF 186
+C +F C C G+ G+ C KDV C + GC IC N S+ C C GF
Sbjct: 539 SCVSSEDSFVCQCFEGYILREDGKTCRRKDV--CQAIDHGCEHICVNSDDSYTCECLEGF 596
Query: 187 ELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGR 246
L+ DG+ C+ D C + E C N SY C C EGF + + C+ +C +G
Sbjct: 597 RLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCK---KCTEGP 653
Query: 247 CEQVCV 252
+ V V
Sbjct: 654 IDLVFV 659
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 122 bits (306), Expect = 1e-27
Identities = 76/197 (38%), Positives = 98/197 (49%), Gaps = 20/197 (10%)
Query: 100 GSPYTKNSGFATCVQNLPDQCTP--NPCDRKGTQACQDLMGNFFCLCKAGWG----GRLC 153
G Y N CV D+C P PC + C + G+F C CK G+ R+C
Sbjct: 342 GRGYHLNEEGTRCVD--VDECAPPAEPCGKG--HRCVNSPGSFRCECKTGYYFDGISRMC 397
Query: 154 DKDVNECSQENGG-CLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARC 212
DVNEC + G C C N GS+ CSC GF LS DGR+C+DI+EC+ S E C
Sbjct: 398 -VDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQE--C 454
Query: 213 KNLPGSYSCLCDEGFAYSSQEKA-CRDVDECLQGR----CEQVCVNSPGSYTCHCDGRGG 267
N+ GSY C C G+ S + C D+DEC C C+N PGS+ C C G
Sbjct: 455 ANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPS-SG 513
Query: 268 LKLSQDMDTCEDILPCV 284
+L+ + C+DI CV
Sbjct: 514 YRLAPNGRNCQDIDECV 530
Score = 103 bits (257), Expect = 5e-22
Identities = 63/165 (38%), Positives = 82/165 (49%), Gaps = 17/165 (10%)
Query: 128 KGTQACQDLMGNFFCLCKAGWG----GRLCDKDVNECSQENGGCLQ--ICHNKPGSFHCS 181
+G+ CQ + N C G+ G C DV+EC+ C + C N PGSF C
Sbjct: 329 EGSYTCQKNVPN----CGRGYHLNEEGTRC-VDVDECAPPAEPCGKGHRCVNSPGSFRCE 383
Query: 182 CHSGFELSSDGRTCQDIDECA--DSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDV 239
C +G+ R C D++EC CG +C+N GSY C C GF S ++C D+
Sbjct: 384 CKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDI 442
Query: 240 DECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQ-DMDTCEDILPC 283
+EC C Q C N GSY C+C R G +LS D TCEDI C
Sbjct: 443 NECSSSPCSQECANVYGSYQCYC--RRGYQLSDVDGVTCEDIDEC 485
Score = 102 bits (253), Expect = 2e-21
Identities = 54/141 (38%), Positives = 77/141 (54%), Gaps = 17/141 (12%)
Query: 133 CQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFEL 188
C++ +G++ C C G+ GR C+ D+NECS + C Q C N GS+ C C G++L
Sbjct: 415 CENTLGSYLCSCSVGFRLSVDGRSCE-DINECS--SSPCSQECANVYGSYQCYCRRGYQL 471
Query: 189 SS-DGRTCQDIDECA---DSEACGEARCKNLPGSYSCLC-DEGFAYSSQEKACRDVDECL 243
S DG TC+DIDECA C RC N+PGS+ C C G+ + + C+D+DEC+
Sbjct: 472 SDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECV 530
Query: 244 QG----RCEQVCVNSPGSYTC 260
G + C N G + C
Sbjct: 531 TGIHNCSINETCFNIQGGFRC 551
Score = 82.8 bits (203), Expect = 1e-15
Identities = 66/195 (33%), Positives = 90/195 (46%), Gaps = 33/195 (16%)
Query: 116 LPDQCTPN-PCDRKGTQACQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCL-- 168
L D+C PC Q C+D C C G+ G C+ DVNEC + C
Sbjct: 176 LNDRCRGGGPCK----QQCRDTGDEVVCSCFVGYQLLSDGVSCE-DVNECITGSHSCRLG 230
Query: 169 QICHNKPGSFHC----SCHSGFELSSDGRTCQDIDECADS--EACGEARCKNLPGSYSCL 222
+ C N GSF C SC +G+EL+ D +C+DIDEC + C+N GS+ C
Sbjct: 231 ESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCR 289
Query: 223 ----CDEGFAYSSQEKACRDVDECLQ--GRCE--QVCVNSPGSYTCHCD----GRGGLKL 270
C GF + C D++ECL C C+N+ GSYTC + GR G L
Sbjct: 290 PKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR-GYHL 347
Query: 271 SQDMDTCEDILPCVP 285
+++ C D+ C P
Sbjct: 348 NEEGTRCVDVDECAP 362
Score = 82.0 bits (201), Expect = 2e-15
Identities = 47/127 (37%), Positives = 69/127 (54%), Gaps = 18/127 (14%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW-----GGRLCDKDVNECSQENGG--CLQI 170
++C+ +PC +Q C ++ G++ C C+ G+ G C+ D++EC+ GG C
Sbjct: 443 NECSSSPC----SQECANVYGSYQCYCRRGYQLSDVDGVTCE-DIDECALPTGGHICSYR 497
Query: 171 CHNKPGSFHCSC-HSGFELSSDGRTCQDIDECADS-EACG-EARCKNLPGSYSCL---CD 224
C N PGSF CSC SG+ L+ +GR CQDIDEC C C N+ G + CL C
Sbjct: 498 CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
Query: 225 EGFAYSS 231
E + S+
Sbjct: 558 ENYRRSA 564
Score = 73.9 bits (180), Expect = 4e-13
Identities = 49/145 (33%), Positives = 75/145 (51%), Gaps = 12/145 (8%)
Query: 154 DKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDEC-ADSEAC--GEA 210
D +N+ + G C Q C + CSC G++L SDG +C+D++EC S +C GE+
Sbjct: 173 DPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGES 232
Query: 211 RCKNLPGSYSCLCDE--GFAYS-SQEKACRDVDECLQG--RC--EQVCVNSPGSYTCHCD 263
C N GS+ C D G Y +++ +C+D+DEC G C + +C N+ GS+ C
Sbjct: 233 -CINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPK 291
Query: 264 GRGGLKLSQD-MDTCEDILPCVPFS 287
+ QD + C DI C+ S
Sbjct: 292 LQCKSGFIQDALGNCIDINECLSIS 316
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 122 bits (306), Expect = 1e-27
Identities = 76/197 (38%), Positives = 98/197 (49%), Gaps = 20/197 (10%)
Query: 100 GSPYTKNSGFATCVQNLPDQCTP--NPCDRKGTQACQDLMGNFFCLCKAGWG----GRLC 153
G Y N CV D+C P PC + C + G+F C CK G+ R+C
Sbjct: 342 GRGYHLNEEGTRCVD--VDECAPPAEPCGKG--HRCVNSPGSFRCECKTGYYFDGISRMC 397
Query: 154 DKDVNECSQENGG-CLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARC 212
DVNEC + G C C N GS+ CSC GF LS DGR+C+DI+EC+ S E C
Sbjct: 398 -VDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQE--C 454
Query: 213 KNLPGSYSCLCDEGFAYSSQEKA-CRDVDECLQGR----CEQVCVNSPGSYTCHCDGRGG 267
N+ GSY C C G+ S + C D+DEC C C+N PGS+ C C G
Sbjct: 455 ANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPS-SG 513
Query: 268 LKLSQDMDTCEDILPCV 284
+L+ + C+DI CV
Sbjct: 514 YRLAPNGRNCQDIDECV 530
Score = 103 bits (257), Expect = 5e-22
Identities = 63/165 (38%), Positives = 82/165 (49%), Gaps = 17/165 (10%)
Query: 128 KGTQACQDLMGNFFCLCKAGWG----GRLCDKDVNECSQENGGCLQ--ICHNKPGSFHCS 181
+G+ CQ + N C G+ G C DV+EC+ C + C N PGSF C
Sbjct: 329 EGSYTCQKNVPN----CGRGYHLNEEGTRC-VDVDECAPPAEPCGKGHRCVNSPGSFRCE 383
Query: 182 CHSGFELSSDGRTCQDIDECA--DSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDV 239
C +G+ R C D++EC CG +C+N GSY C C GF S ++C D+
Sbjct: 384 CKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDI 442
Query: 240 DECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQ-DMDTCEDILPC 283
+EC C Q C N GSY C+C R G +LS D TCEDI C
Sbjct: 443 NECSSSPCSQECANVYGSYQCYC--RRGYQLSDVDGVTCEDIDEC 485
Score = 102 bits (253), Expect = 2e-21
Identities = 54/141 (38%), Positives = 77/141 (54%), Gaps = 17/141 (12%)
Query: 133 CQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFEL 188
C++ +G++ C C G+ GR C+ D+NECS + C Q C N GS+ C C G++L
Sbjct: 415 CENTLGSYLCSCSVGFRLSVDGRSCE-DINECS--SSPCSQECANVYGSYQCYCRRGYQL 471
Query: 189 SS-DGRTCQDIDECA---DSEACGEARCKNLPGSYSCLC-DEGFAYSSQEKACRDVDECL 243
S DG TC+DIDECA C RC N+PGS+ C C G+ + + C+D+DEC+
Sbjct: 472 SDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECV 530
Query: 244 QG----RCEQVCVNSPGSYTC 260
G + C N G + C
Sbjct: 531 TGIHNCSINETCFNIQGGFRC 551
Score = 82.8 bits (203), Expect = 1e-15
Identities = 66/195 (33%), Positives = 90/195 (46%), Gaps = 33/195 (16%)
Query: 116 LPDQCTPN-PCDRKGTQACQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCL-- 168
L D+C PC Q C+D C C G+ G C+ DVNEC + C
Sbjct: 176 LNDRCRGGGPCK----QQCRDTGDEVVCSCFVGYQLLSDGVSCE-DVNECITGSHSCRLG 230
Query: 169 QICHNKPGSFHC----SCHSGFELSSDGRTCQDIDECADS--EACGEARCKNLPGSYSCL 222
+ C N GSF C SC +G+EL+ D +C+DIDEC + C+N GS+ C
Sbjct: 231 ESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCR 289
Query: 223 ----CDEGFAYSSQEKACRDVDECLQ--GRCE--QVCVNSPGSYTCHCD----GRGGLKL 270
C GF + C D++ECL C C+N+ GSYTC + GR G L
Sbjct: 290 PKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR-GYHL 347
Query: 271 SQDMDTCEDILPCVP 285
+++ C D+ C P
Sbjct: 348 NEEGTRCVDVDECAP 362
Score = 82.0 bits (201), Expect = 2e-15
Identities = 47/127 (37%), Positives = 69/127 (54%), Gaps = 18/127 (14%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW-----GGRLCDKDVNECSQENGG--CLQI 170
++C+ +PC +Q C ++ G++ C C+ G+ G C+ D++EC+ GG C
Sbjct: 443 NECSSSPC----SQECANVYGSYQCYCRRGYQLSDVDGVTCE-DIDECALPTGGHICSYR 497
Query: 171 CHNKPGSFHCSC-HSGFELSSDGRTCQDIDECADS-EACG-EARCKNLPGSYSCL---CD 224
C N PGSF CSC SG+ L+ +GR CQDIDEC C C N+ G + CL C
Sbjct: 498 CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
Query: 225 EGFAYSS 231
E + S+
Sbjct: 558 ENYRRSA 564
Score = 73.9 bits (180), Expect = 4e-13
Identities = 49/145 (33%), Positives = 75/145 (51%), Gaps = 12/145 (8%)
Query: 154 DKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDEC-ADSEAC--GEA 210
D +N+ + G C Q C + CSC G++L SDG +C+D++EC S +C GE+
Sbjct: 173 DPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGES 232
Query: 211 RCKNLPGSYSCLCDE--GFAYS-SQEKACRDVDECLQG--RC--EQVCVNSPGSYTCHCD 263
C N GS+ C D G Y +++ +C+D+DEC G C + +C N+ GS+ C
Sbjct: 233 -CINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPK 291
Query: 264 GRGGLKLSQD-MDTCEDILPCVPFS 287
+ QD + C DI C+ S
Sbjct: 292 LQCKSGFIQDALGNCIDINECLSIS 316
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 122 bits (306), Expect = 1e-27
Identities = 76/197 (38%), Positives = 98/197 (49%), Gaps = 20/197 (10%)
Query: 100 GSPYTKNSGFATCVQNLPDQCTP--NPCDRKGTQACQDLMGNFFCLCKAGWG----GRLC 153
G Y N CV D+C P PC + C + G+F C CK G+ R+C
Sbjct: 342 GRGYHLNEEGTRCVD--VDECAPPAEPCGKG--HRCVNSPGSFRCECKTGYYFDGISRMC 397
Query: 154 DKDVNECSQENGG-CLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARC 212
DVNEC + G C C N GS+ CSC GF LS DGR+C+DI+EC+ S E C
Sbjct: 398 -VDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQE--C 454
Query: 213 KNLPGSYSCLCDEGFAYSSQEKA-CRDVDECLQGR----CEQVCVNSPGSYTCHCDGRGG 267
N+ GSY C C G+ S + C D+DEC C C+N PGS+ C C G
Sbjct: 455 ANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPS-SG 513
Query: 268 LKLSQDMDTCEDILPCV 284
+L+ + C+DI CV
Sbjct: 514 YRLAPNGRNCQDIDECV 530
Score = 103 bits (257), Expect = 5e-22
Identities = 63/165 (38%), Positives = 82/165 (49%), Gaps = 17/165 (10%)
Query: 128 KGTQACQDLMGNFFCLCKAGWG----GRLCDKDVNECSQENGGCLQ--ICHNKPGSFHCS 181
+G+ CQ + N C G+ G C DV+EC+ C + C N PGSF C
Sbjct: 329 EGSYTCQKNVPN----CGRGYHLNEEGTRC-VDVDECAPPAEPCGKGHRCVNSPGSFRCE 383
Query: 182 CHSGFELSSDGRTCQDIDECA--DSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDV 239
C +G+ R C D++EC CG +C+N GSY C C GF S ++C D+
Sbjct: 384 CKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDI 442
Query: 240 DECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQ-DMDTCEDILPC 283
+EC C Q C N GSY C+C R G +LS D TCEDI C
Sbjct: 443 NECSSSPCSQECANVYGSYQCYC--RRGYQLSDVDGVTCEDIDEC 485
Score = 84.7 bits (208), Expect = 3e-16
Identities = 55/159 (34%), Positives = 78/159 (49%), Gaps = 23/159 (14%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW-----GGRLCDKDVNECSQENGG--CLQI 170
++C+ +PC +Q C ++ G++ C C+ G+ G C+ D++EC+ GG C
Sbjct: 443 NECSSSPC----SQECANVYGSYQCYCRRGYQLSDVDGVTCE-DIDECALPTGGHICSYR 497
Query: 171 CHNKPGSFHCSC-HSGFELSSDGRTCQDIDECADS-EACG-EARCKNLPGSYSCL---CD 224
C N PGSF CSC SG+ L+ +GR CQDIDEC C C N+ G + CL C
Sbjct: 498 CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
Query: 225 EGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCD 263
E + S+ D RC + C P TC D
Sbjct: 558 ENYRRSAATLQQEKTDTV---RCIKSC--RPNDVTCVFD 591
Score = 82.8 bits (203), Expect = 1e-15
Identities = 66/195 (33%), Positives = 90/195 (46%), Gaps = 33/195 (16%)
Query: 116 LPDQCTPN-PCDRKGTQACQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCL-- 168
L D+C PC Q C+D C C G+ G C+ DVNEC + C
Sbjct: 176 LNDRCRGGGPCK----QQCRDTGDEVVCSCFVGYQLLSDGVSCE-DVNECITGSHSCRLG 230
Query: 169 QICHNKPGSFHC----SCHSGFELSSDGRTCQDIDECADS--EACGEARCKNLPGSYSCL 222
+ C N GSF C SC +G+EL+ D +C+DIDEC + C+N GS+ C
Sbjct: 231 ESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCR 289
Query: 223 ----CDEGFAYSSQEKACRDVDECLQ--GRCE--QVCVNSPGSYTCHCD----GRGGLKL 270
C GF + C D++ECL C C+N+ GSYTC + GR G L
Sbjct: 290 PKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR-GYHL 347
Query: 271 SQDMDTCEDILPCVP 285
+++ C D+ C P
Sbjct: 348 NEEGTRCVDVDECAP 362
Score = 73.9 bits (180), Expect = 4e-13
Identities = 49/145 (33%), Positives = 75/145 (51%), Gaps = 12/145 (8%)
Query: 154 DKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDEC-ADSEAC--GEA 210
D +N+ + G C Q C + CSC G++L SDG +C+D++EC S +C GE+
Sbjct: 173 DPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGES 232
Query: 211 RCKNLPGSYSCLCDE--GFAYS-SQEKACRDVDECLQG--RC--EQVCVNSPGSYTCHCD 263
C N GS+ C D G Y +++ +C+D+DEC G C + +C N+ GS+ C
Sbjct: 233 -CINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPK 291
Query: 264 GRGGLKLSQD-MDTCEDILPCVPFS 287
+ QD + C DI C+ S
Sbjct: 292 LQCKSGFIQDALGNCIDINECLSIS 316
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 122 bits (306), Expect = 1e-27
Identities = 76/197 (38%), Positives = 98/197 (49%), Gaps = 20/197 (10%)
Query: 100 GSPYTKNSGFATCVQNLPDQCTP--NPCDRKGTQACQDLMGNFFCLCKAGWG----GRLC 153
G Y N CV D+C P PC + C + G+F C CK G+ R+C
Sbjct: 342 GRGYHLNEEGTRCVD--VDECAPPAEPCGKG--HRCVNSPGSFRCECKTGYYFDGISRMC 397
Query: 154 DKDVNECSQENGG-CLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARC 212
DVNEC + G C C N GS+ CSC GF LS DGR+C+DI+EC+ S E C
Sbjct: 398 -VDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQE--C 454
Query: 213 KNLPGSYSCLCDEGFAYSSQEKA-CRDVDECLQGR----CEQVCVNSPGSYTCHCDGRGG 267
N+ GSY C C G+ S + C D+DEC C C+N PGS+ C C G
Sbjct: 455 ANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPS-SG 513
Query: 268 LKLSQDMDTCEDILPCV 284
+L+ + C+DI CV
Sbjct: 514 YRLAPNGRNCQDIDECV 530
Score = 103 bits (257), Expect = 5e-22
Identities = 63/165 (38%), Positives = 82/165 (49%), Gaps = 17/165 (10%)
Query: 128 KGTQACQDLMGNFFCLCKAGWG----GRLCDKDVNECSQENGGCLQ--ICHNKPGSFHCS 181
+G+ CQ + N C G+ G C DV+EC+ C + C N PGSF C
Sbjct: 329 EGSYTCQKNVPN----CGRGYHLNEEGTRC-VDVDECAPPAEPCGKGHRCVNSPGSFRCE 383
Query: 182 CHSGFELSSDGRTCQDIDECA--DSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDV 239
C +G+ R C D++EC CG +C+N GSY C C GF S ++C D+
Sbjct: 384 CKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCEDI 442
Query: 240 DECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQ-DMDTCEDILPC 283
+EC C Q C N GSY C+C R G +LS D TCEDI C
Sbjct: 443 NECSSSPCSQECANVYGSYQCYC--RRGYQLSDVDGVTCEDIDEC 485
Score = 102 bits (253), Expect = 2e-21
Identities = 54/141 (38%), Positives = 77/141 (54%), Gaps = 17/141 (12%)
Query: 133 CQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFEL 188
C++ +G++ C C G+ GR C+ D+NECS + C Q C N GS+ C C G++L
Sbjct: 415 CENTLGSYLCSCSVGFRLSVDGRSCE-DINECS--SSPCSQECANVYGSYQCYCRRGYQL 471
Query: 189 SS-DGRTCQDIDECA---DSEACGEARCKNLPGSYSCLC-DEGFAYSSQEKACRDVDECL 243
S DG TC+DIDECA C RC N+PGS+ C C G+ + + C+D+DEC+
Sbjct: 472 SDVDGVTCEDIDECALPTGGHICSY-RCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECV 530
Query: 244 QG----RCEQVCVNSPGSYTC 260
G + C N G + C
Sbjct: 531 TGIHNCSINETCFNIQGGFRC 551
Score = 84.0 bits (206), Expect = 4e-16
Identities = 50/142 (35%), Positives = 74/142 (52%), Gaps = 22/142 (15%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW-----GGRLCDKDVNECSQENGG--CLQI 170
++C+ +PC +Q C ++ G++ C C+ G+ G C+ D++EC+ GG C
Sbjct: 443 NECSSSPC----SQECANVYGSYQCYCRRGYQLSDVDGVTCE-DIDECALPTGGHICSYR 497
Query: 171 CHNKPGSFHCSC-HSGFELSSDGRTCQDIDECADS-EACG-EARCKNLPGSYSCL---CD 224
C N PGSF CSC SG+ L+ +GR CQDIDEC C C N+ G + CL C
Sbjct: 498 CINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
Query: 225 EGFAYSSQEKA----CRDVDEC 242
E + S+ + C + EC
Sbjct: 558 ENYRRSAATRCERLPCHENREC 579
Score = 82.8 bits (203), Expect = 1e-15
Identities = 66/195 (33%), Positives = 90/195 (46%), Gaps = 33/195 (16%)
Query: 116 LPDQCTPN-PCDRKGTQACQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCL-- 168
L D+C PC Q C+D C C G+ G C+ DVNEC + C
Sbjct: 176 LNDRCRGGGPCK----QQCRDTGDEVVCSCFVGYQLLSDGVSCE-DVNECITGSHSCRLG 230
Query: 169 QICHNKPGSFHC----SCHSGFELSSDGRTCQDIDECADS--EACGEARCKNLPGSYSCL 222
+ C N GSF C SC +G+EL+ D +C+DIDEC + C+N GS+ C
Sbjct: 231 ESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCR 289
Query: 223 ----CDEGFAYSSQEKACRDVDECLQ--GRCE--QVCVNSPGSYTCHCD----GRGGLKL 270
C GF + C D++ECL C C+N+ GSYTC + GR G L
Sbjct: 290 PKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGR-GYHL 347
Query: 271 SQDMDTCEDILPCVP 285
+++ C D+ C P
Sbjct: 348 NEEGTRCVDVDECAP 362
Score = 73.9 bits (180), Expect = 4e-13
Identities = 49/145 (33%), Positives = 75/145 (51%), Gaps = 12/145 (8%)
Query: 154 DKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDEC-ADSEAC--GEA 210
D +N+ + G C Q C + CSC G++L SDG +C+D++EC S +C GE+
Sbjct: 173 DPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGES 232
Query: 211 RCKNLPGSYSCLCDE--GFAYS-SQEKACRDVDECLQG--RC--EQVCVNSPGSYTCHCD 263
C N GS+ C D G Y +++ +C+D+DEC G C + +C N+ GS+ C
Sbjct: 233 -CINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPK 291
Query: 264 GRGGLKLSQD-MDTCEDILPCVPFS 287
+ QD + C DI C+ S
Sbjct: 292 LQCKSGFIQDALGNCIDINECLSIS 316
>gi|194328809 latent transforming growth factor beta binding protein
3 isoform 1 [Homo sapiens]
Length = 1303
Score = 122 bits (305), Expect = 1e-27
Identities = 72/193 (37%), Positives = 102/193 (52%), Gaps = 19/193 (9%)
Query: 118 DQCT-PNPC-DRKGTQACQDLMGNFFCL-CKAGW---GGRLCDKDVNECSQENGGCLQIC 171
D+C P+ C D K C++ G+F C+ C+ G+ GG C +DVNEC++ + C
Sbjct: 705 DECRDPSSCPDGK----CENKPGSFKCIACQPGYRSQGGGAC-RDVNECAEGSPCSPGWC 759
Query: 172 HNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSS 231
N PGSF C+C G+ + DGR+C D+DEC + C C N PGS+ C C G+ S
Sbjct: 760 ENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSR 819
Query: 232 QEKACRDVDEC-LQGRC-EQVCVNSPGSYTCHCDGR----GGLKLSQDMDTC-EDILPCV 284
C D+DEC C C+N+ GSY C C GG K QD+D C +D C+
Sbjct: 820 DRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRK-CQDIDECSQDPSLCL 878
Query: 285 PFSVAKSVKSLYL 297
P K+++ Y+
Sbjct: 879 PHGACKNLQGSYV 891
Score = 110 bits (275), Expect = 4e-24
Identities = 69/183 (37%), Positives = 96/183 (52%), Gaps = 32/183 (17%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW------GGRLCDKDVNECSQEN----GGC 167
++C PC G C + G++ C C G+ GGR C D+NEC++ + GG
Sbjct: 618 NECEAEPCG-PGRGICMNTGGSYNCHCNRGYRLHVGAGGRSC-VDLNECAKPHLCGDGG- 674
Query: 168 LQICHNKPGSFHCSCHSGFEL-SSDGRTCQDIDECADSEACGEARCKNLPGSYSCL-CDE 225
C N PG + C+C+ G+ L +S C+DIDEC D +C + +C+N PGS+ C+ C
Sbjct: 675 --FCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQP 732
Query: 226 GFAYSSQEKACRDVDECLQGR-CEQ-VCVNSPGSYTCHC--------DGRGGLKLSQDMD 275
G+ S ACRDV+EC +G C C N PGS+ C C DGR L D+D
Sbjct: 733 GYR-SQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCL----DVD 787
Query: 276 TCE 278
CE
Sbjct: 788 ECE 790
Score = 92.0 bits (227), Expect = 2e-18
Identities = 79/260 (30%), Positives = 103/260 (39%), Gaps = 75/260 (28%)
Query: 95 CINKYGS-------PYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAG 147
C NK GS P ++ G C +++ + +PC C++L G+F C C G
Sbjct: 718 CENKPGSFKCIACQPGYRSQGGGAC-RDVNECAEGSPCSPGW---CENLPGSFRCTCAQG 773
Query: 148 WG----GRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSD------------ 191
+ GR C DV+EC + IC N PGSF C C SG+ LS D
Sbjct: 774 YAPAPDGRSC-LDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDF 832
Query: 192 ----------------------------GRTCQDIDECA-DSEAC-GEARCKNLPGSYSC 221
GR CQDIDEC+ D C CKNL GSY C
Sbjct: 833 PAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC 892
Query: 222 LCDEGFAYSSQEKACRDVD------ECLQG-----RCEQVCVNSPGSYTCHCDGRGGLKL 270
+CDEGF + + C +V+ EC C+ V + C C G
Sbjct: 893 VCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWG- 951
Query: 271 SQDMDTCEDILPCVPFSVAK 290
D CE I PC +S A+
Sbjct: 952 ----DHCE-IYPCPVYSSAE 966
Score = 74.7 bits (182), Expect = 3e-13
Identities = 52/168 (30%), Positives = 66/168 (39%), Gaps = 34/168 (20%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGWG----------GRLCDKDVNECSQ----- 162
D C PC + F LC G G G +D++EC
Sbjct: 952 DHCEIYPCPVYSS-------AEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEI 1004
Query: 163 -ENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSC 221
+ G C+ + +PG + C C GF + C D+DEC D C C+N G Y C
Sbjct: 1005 CKEGKCV---NTQPG-YECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRC 1060
Query: 222 LCDEGFAYSSQEKAC-----RDVDECLQ-GRCEQ-VCVNSPGSYTCHC 262
C YS ++ C DVDEC C CVN PGSY C C
Sbjct: 1061 ACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCEC 1108
Score = 74.3 bits (181), Expect = 3e-13
Identities = 69/256 (26%), Positives = 91/256 (35%), Gaps = 65/256 (25%)
Query: 94 DCINKYGS-----PYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGW 148
DCIN GS P Q++ D+C+ +P AC++L G++ C+C G+
Sbjct: 840 DCINTNGSYRCLCPQGHRLVGGRKCQDI-DECSQDPSLCLPHGACKNLQGSYVCVCDEGF 898
Query: 149 GGR--------------------------LCDK----DVNE---CSQENGGCLQICHNKP 175
CD +V + C G C P
Sbjct: 899 TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYP 958
Query: 176 ------GSFHCSCHSGFELSSDGRTC-------QDIDECA--DSEACGEARCKNLPGSYS 220
FH C G + D +DIDEC SE C E +C N Y
Sbjct: 959 CPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYE 1018
Query: 221 CLCDEGFAYSSQEKACRDVDECL-QGRCEQ-VCVNSPGSYTCHCDGRGGLKLSQ------ 272
C C +GF Y C DVDECL + C VC N+ G Y C C +Q
Sbjct: 1019 CYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSP 1078
Query: 273 ---DMDTCEDILPCVP 285
D+D C+D C P
Sbjct: 1079 EEMDVDECQDPAACRP 1094
Score = 73.6 bits (179), Expect = 6e-13
Identities = 42/125 (33%), Positives = 62/125 (49%), Gaps = 13/125 (10%)
Query: 171 CHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEAR--CKNLPGSYSCLCDEGFA 228
C P + C C+ G+ R C D++EC ++E CG R C N GSY+C C+ G+
Sbjct: 590 CVPGPPDYSCHCNPGYRSHPQHRYCVDVNEC-EAEPCGPGRGICMNTGGSYNCHCNRGYR 648
Query: 229 --YSSQEKACRDVDECLQGR-CEQ--VCVNSPGSYTCHCDGRGGLKLS-----QDMDTCE 278
+ ++C D++EC + C C+N PG Y C+C LK S +D+D C
Sbjct: 649 LHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECR 708
Query: 279 DILPC 283
D C
Sbjct: 709 DPSSC 713
Score = 63.9 bits (154), Expect = 5e-10
Identities = 32/87 (36%), Positives = 43/87 (49%), Gaps = 8/87 (9%)
Query: 154 DKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSE----ACGE 209
++D +EC +G C+ +PG C C GF+L + C DIDEC + C
Sbjct: 1215 EEDSDECRCVSGRCVP----RPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKS 1270
Query: 210 ARCKNLPGSYSCLCDEGFAYSSQEKAC 236
RC N GS+ C+C GFA S AC
Sbjct: 1271 ERCVNTSGSFRCVCKAGFARSRPHGAC 1297
Score = 62.8 bits (151), Expect = 1e-09
Identities = 31/91 (34%), Positives = 44/91 (48%), Gaps = 4/91 (4%)
Query: 197 DIDECA-DSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRC---EQVCV 252
+ DEC + CG C P YSC C+ G+ Q + C DV+EC C +C+
Sbjct: 574 ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
Query: 253 NSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
N+ GSY CHC+ L + +C D+ C
Sbjct: 634 NTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC 664
Score = 48.9 bits (115), Expect = 2e-05
Identities = 39/127 (30%), Positives = 49/127 (38%), Gaps = 13/127 (10%)
Query: 112 CVQN-LPDQ-CTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQ 169
C Q+ LP Q C NP G +D G+ WG C K C Q +Q
Sbjct: 279 CFQDTLPKQPCGSNPLP--GLTKQEDCCGSI----GTAWGQSKCHK----CPQLQYTGVQ 328
Query: 170 ICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAY 229
G C G++ + CQDI+ECA C C N PGSY C+C G +
Sbjct: 329 KPGPVRGEVGADCPQGYKRLNSTH-CQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
Query: 230 SSQEKAC 236
C
Sbjct: 388 GPSRTQC 394
Score = 48.5 bits (114), Expect = 2e-05
Identities = 29/88 (32%), Positives = 39/88 (44%), Gaps = 12/88 (13%)
Query: 196 QDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGR-----CE-Q 249
+D DEC C RC PG C C GF + C D+DEC + C+ +
Sbjct: 1216 EDSDECR----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSE 1271
Query: 250 VCVNSPGSYTCHCDGRGGLKLSQDMDTC 277
CVN+ GS+ C C + G S+ C
Sbjct: 1272 RCVNTSGSFRCVC--KAGFARSRPHGAC 1297
Score = 47.4 bits (111), Expect = 4e-05
Identities = 63/254 (24%), Positives = 85/254 (33%), Gaps = 77/254 (30%)
Query: 94 DCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLC----KAGWG 149
+C K G Y N CV D+C R G C++ G + C C +
Sbjct: 1018 ECYCKQGFYYDGN--LLECVD--VDECLDESNCRNGV--CENTRGGYRCACTPPAEYSPA 1071
Query: 150 GRLC----DKDVNECSQENGGCLQ-ICHNKPGSFHCSCHSGFELSSDGRTCQDIDECAD- 203
R C + DV+EC Q+ C C N PGS+ C C + GR CQ + A+
Sbjct: 1072 QRQCLSPEEMDVDEC-QDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAER 1130
Query: 204 ----SEACGEARCKN------LPGSY----SCLCDEGFAYSSQEKAC------------- 236
+ C R ++ L G C C +G + +Q + C
Sbjct: 1131 APERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQ 1190
Query: 237 ------------------RDVD---------ECLQGRCEQVCVNSPGSYTCHCDGRGGLK 269
RD D C+ GR CV PG C C GG +
Sbjct: 1191 SESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGR----CVPRPGGAVCECP--GGFQ 1244
Query: 270 LSQDMDTCEDILPC 283
L C DI C
Sbjct: 1245 LDASRARCVDIDEC 1258
Score = 35.8 bits (81), Expect = 0.13
Identities = 23/82 (28%), Positives = 37/82 (45%), Gaps = 19/82 (23%)
Query: 199 DECADS--EACGEARCKNLP--------------GSYSCLCDEGFAYSSQEKACRDVDEC 242
++C S A G+++C P G C +G+ + C+D++EC
Sbjct: 301 EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTH-CQDINEC 359
Query: 243 -LQGRCEQV-CVNSPGSYTCHC 262
+ G C C+N+PGSY C C
Sbjct: 360 AMPGVCRHGDCLNNPGSYRCVC 381
>gi|18497288 latent transforming growth factor beta binding protein
3 isoform 2 [Homo sapiens]
Length = 1256
Score = 122 bits (305), Expect = 1e-27
Identities = 72/193 (37%), Positives = 102/193 (52%), Gaps = 19/193 (9%)
Query: 118 DQCT-PNPC-DRKGTQACQDLMGNFFCL-CKAGW---GGRLCDKDVNECSQENGGCLQIC 171
D+C P+ C D K C++ G+F C+ C+ G+ GG C +DVNEC++ + C
Sbjct: 705 DECRDPSSCPDGK----CENKPGSFKCIACQPGYRSQGGGAC-RDVNECAEGSPCSPGWC 759
Query: 172 HNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSS 231
N PGSF C+C G+ + DGR+C D+DEC + C C N PGS+ C C G+ S
Sbjct: 760 ENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSR 819
Query: 232 QEKACRDVDEC-LQGRC-EQVCVNSPGSYTCHCDGR----GGLKLSQDMDTC-EDILPCV 284
C D+DEC C C+N+ GSY C C GG K QD+D C +D C+
Sbjct: 820 DRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRK-CQDIDECSQDPSLCL 878
Query: 285 PFSVAKSVKSLYL 297
P K+++ Y+
Sbjct: 879 PHGACKNLQGSYV 891
Score = 110 bits (275), Expect = 4e-24
Identities = 69/183 (37%), Positives = 96/183 (52%), Gaps = 32/183 (17%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW------GGRLCDKDVNECSQEN----GGC 167
++C PC G C + G++ C C G+ GGR C D+NEC++ + GG
Sbjct: 618 NECEAEPCG-PGRGICMNTGGSYNCHCNRGYRLHVGAGGRSC-VDLNECAKPHLCGDGG- 674
Query: 168 LQICHNKPGSFHCSCHSGFEL-SSDGRTCQDIDECADSEACGEARCKNLPGSYSCL-CDE 225
C N PG + C+C+ G+ L +S C+DIDEC D +C + +C+N PGS+ C+ C
Sbjct: 675 --FCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQP 732
Query: 226 GFAYSSQEKACRDVDECLQGR-CEQ-VCVNSPGSYTCHC--------DGRGGLKLSQDMD 275
G+ S ACRDV+EC +G C C N PGS+ C C DGR L D+D
Sbjct: 733 GYR-SQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCL----DVD 787
Query: 276 TCE 278
CE
Sbjct: 788 ECE 790
Score = 92.0 bits (227), Expect = 2e-18
Identities = 79/260 (30%), Positives = 103/260 (39%), Gaps = 75/260 (28%)
Query: 95 CINKYGS-------PYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAG 147
C NK GS P ++ G C +++ + +PC C++L G+F C C G
Sbjct: 718 CENKPGSFKCIACQPGYRSQGGGAC-RDVNECAEGSPCSPGW---CENLPGSFRCTCAQG 773
Query: 148 WG----GRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSD------------ 191
+ GR C DV+EC + IC N PGSF C C SG+ LS D
Sbjct: 774 YAPAPDGRSC-LDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDF 832
Query: 192 ----------------------------GRTCQDIDECA-DSEAC-GEARCKNLPGSYSC 221
GR CQDIDEC+ D C CKNL GSY C
Sbjct: 833 PAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC 892
Query: 222 LCDEGFAYSSQEKACRDVD------ECLQG-----RCEQVCVNSPGSYTCHCDGRGGLKL 270
+CDEGF + + C +V+ EC C+ V + C C G
Sbjct: 893 VCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWG- 951
Query: 271 SQDMDTCEDILPCVPFSVAK 290
D CE I PC +S A+
Sbjct: 952 ----DHCE-IYPCPVYSSAE 966
Score = 73.6 bits (179), Expect = 6e-13
Identities = 42/125 (33%), Positives = 62/125 (49%), Gaps = 13/125 (10%)
Query: 171 CHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEAR--CKNLPGSYSCLCDEGFA 228
C P + C C+ G+ R C D++EC ++E CG R C N GSY+C C+ G+
Sbjct: 590 CVPGPPDYSCHCNPGYRSHPQHRYCVDVNEC-EAEPCGPGRGICMNTGGSYNCHCNRGYR 648
Query: 229 --YSSQEKACRDVDECLQGR-CEQ--VCVNSPGSYTCHCDGRGGLKLS-----QDMDTCE 278
+ ++C D++EC + C C+N PG Y C+C LK S +D+D C
Sbjct: 649 LHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECR 708
Query: 279 DILPC 283
D C
Sbjct: 709 DPSSC 713
Score = 69.7 bits (169), Expect = 8e-12
Identities = 62/224 (27%), Positives = 81/224 (36%), Gaps = 56/224 (25%)
Query: 94 DCINKYGS-----PYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGW 148
DCIN GS P Q++ D+C+ +P AC++L G++ C+C G+
Sbjct: 840 DCINTNGSYRCLCPQGHRLVGGRKCQDI-DECSQDPSLCLPHGACKNLQGSYVCVCDEGF 898
Query: 149 GGR--------------------------LCDK----DVNE---CSQENGGCLQICHNKP 175
CD +V + C G C P
Sbjct: 899 TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYP 958
Query: 176 ------GSFHCSCHSGFELSSDGRTC-------QDIDECA--DSEACGEARCKNLPGSYS 220
FH C G + D +DIDEC SE C E +C N Y
Sbjct: 959 CPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYE 1018
Query: 221 CLCDEGFAYSSQEKACRDVDECL-QGRCEQ-VCVNSPGSYTCHC 262
C C +GF Y C DVDECL + C VC N+ G Y C C
Sbjct: 1019 CYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCAC 1062
Score = 63.9 bits (154), Expect = 5e-10
Identities = 32/87 (36%), Positives = 43/87 (49%), Gaps = 8/87 (9%)
Query: 154 DKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSE----ACGE 209
++D +EC +G C+ +PG C C GF+L + C DIDEC + C
Sbjct: 1168 EEDSDECRCVSGRCVP----RPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKS 1223
Query: 210 ARCKNLPGSYSCLCDEGFAYSSQEKAC 236
RC N GS+ C+C GFA S AC
Sbjct: 1224 ERCVNTSGSFRCVCKAGFARSRPHGAC 1250
Score = 62.8 bits (151), Expect = 1e-09
Identities = 31/91 (34%), Positives = 44/91 (48%), Gaps = 4/91 (4%)
Query: 197 DIDECA-DSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRC---EQVCV 252
+ DEC + CG C P YSC C+ G+ Q + C DV+EC C +C+
Sbjct: 574 ETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICM 633
Query: 253 NSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
N+ GSY CHC+ L + +C D+ C
Sbjct: 634 NTGGSYNCHCNRGYRLHVGAGGRSCVDLNEC 664
Score = 57.0 bits (136), Expect = 6e-08
Identities = 38/140 (27%), Positives = 53/140 (37%), Gaps = 27/140 (19%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGWG----------GRLCDKDVNECSQ----- 162
D C PC + F LC G G G +D++EC
Sbjct: 952 DHCEIYPCPVYSS-------AEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEI 1004
Query: 163 -ENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSC 221
+ G C+ + +PG + C C GF + C D+DEC D C C+N G Y C
Sbjct: 1005 CKEGKCV---NTQPG-YECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRC 1060
Query: 222 LCDEGFAYSSQEKACRDVDE 241
C YS ++ C +E
Sbjct: 1061 ACTPPAEYSPAQRQCLSPEE 1080
Score = 48.9 bits (115), Expect = 2e-05
Identities = 39/127 (30%), Positives = 49/127 (38%), Gaps = 13/127 (10%)
Query: 112 CVQN-LPDQ-CTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQ 169
C Q+ LP Q C NP G +D G+ WG C K C Q +Q
Sbjct: 279 CFQDTLPKQPCGSNPLP--GLTKQEDCCGSI----GTAWGQSKCHK----CPQLQYTGVQ 328
Query: 170 ICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAY 229
G C G++ + CQDI+ECA C C N PGSY C+C G +
Sbjct: 329 KPGPVRGEVGADCPQGYKRLNSTH-CQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
Query: 230 SSQEKAC 236
C
Sbjct: 388 GPSRTQC 394
Score = 48.5 bits (114), Expect = 2e-05
Identities = 29/88 (32%), Positives = 39/88 (44%), Gaps = 12/88 (13%)
Query: 196 QDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGR-----CE-Q 249
+D DEC C RC PG C C GF + C D+DEC + C+ +
Sbjct: 1169 EDSDECR----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSE 1224
Query: 250 VCVNSPGSYTCHCDGRGGLKLSQDMDTC 277
CVN+ GS+ C C + G S+ C
Sbjct: 1225 RCVNTSGSFRCVC--KAGFARSRPHGAC 1250
Score = 35.8 bits (81), Expect = 0.13
Identities = 23/82 (28%), Positives = 37/82 (45%), Gaps = 19/82 (23%)
Query: 199 DECADS--EACGEARCKNLP--------------GSYSCLCDEGFAYSSQEKACRDVDEC 242
++C S A G+++C P G C +G+ + C+D++EC
Sbjct: 301 EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTH-CQDINEC 359
Query: 243 -LQGRCEQV-CVNSPGSYTCHC 262
+ G C C+N+PGSY C C
Sbjct: 360 AMPGVCRHGDCLNNPGSYRCVC 381
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 121 bits (303), Expect = 2e-27
Identities = 73/210 (34%), Positives = 105/210 (50%), Gaps = 25/210 (11%)
Query: 94 DCINKYGS-------PYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKA 146
+C N GS Y+ G C + + CD + C ++ G+F C C+
Sbjct: 1340 ECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHAS--CLNIPGSFKCSCRE 1397
Query: 147 GW-GGRLCDKDVNECSQENGGCL--QICHNKPGSFHCSCHSGFELSSDGRTCQDIDECAD 203
GW G + D++ECS C C N PGS+ C+C GF + DG TC D+DECA+
Sbjct: 1398 GWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF--TGDGFTCSDVDECAE 1455
Query: 204 S-EACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDEC-LQGRCE-QVCVNSPGSYTC 260
+ C +C N+PG+Y C C+ GF +S ++C+D+DEC Q C C N PG + C
Sbjct: 1456 NINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHC 1515
Query: 261 HCDGRGGLKLSQ------DMDTCEDILPCV 284
CD G +L + D+D C D + CV
Sbjct: 1516 ICD--DGYELDRTGGNCTDIDECADPINCV 1543
Score = 119 bits (297), Expect = 1e-26
Identities = 64/168 (38%), Positives = 86/168 (51%), Gaps = 11/168 (6%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDK---DVNECSQENGGCLQ-ICHN 173
D+CT NPC C + G+++C C AG+ + D++EC Q C C N
Sbjct: 537 DECTSNPCTNGD---CVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVN 593
Query: 174 KPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQE 233
GSF C C++GFEL++DG+ C D DEC + C C N GS+ C+C GF +
Sbjct: 594 TDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNG 653
Query: 234 KACRDVDEC-LQGRC-EQVCVNSPGSYTCHCDGRGGLKLSQDMDTCED 279
+ C DVDEC G C C+NS GS+ C C GL + D C D
Sbjct: 654 RYCTDVDECQTPGICMNGHCINSEGSFRCDCP--PGLAVGMDGRVCVD 699
Score = 116 bits (291), Expect = 6e-26
Identities = 57/153 (37%), Positives = 79/153 (51%), Gaps = 12/153 (7%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW-GGRLCDKDVNECSQ-----ENGGCLQIC 171
D+C+ C + G++ C C G+ G DV+EC++ ENG CL
Sbjct: 1410 DECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCL--- 1466
Query: 172 HNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSS 231
N PG++ C C GF +SD R+CQDIDEC+ C C NLPG + C+CD+G+
Sbjct: 1467 -NVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDR 1525
Query: 232 QEKACRDVDECLQ--GRCEQVCVNSPGSYTCHC 262
C D+DEC +CVN+PG Y C+C
Sbjct: 1526 TGGNCTDIDECADPINCVNGLCVNTPGRYECNC 1558
Score = 116 bits (290), Expect = 8e-26
Identities = 65/182 (35%), Positives = 90/182 (49%), Gaps = 14/182 (7%)
Query: 112 CVQNLPDQCTPNPC-----DRKGTQACQDL----MGNFFCLCKAGWGGRLCDKDVNECSQ 162
CV+ P T + C D + CQ F LC +G G + +D+NEC+
Sbjct: 715 CVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECAL 774
Query: 163 ENGGCLQ-ICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEA-CGEARCKNLPGSYS 220
+ C IC N GS+ C+C+SG+E + GR C DIDEC + C C+N PGSYS
Sbjct: 775 DPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYS 834
Query: 221 CLCDEGFAYSSQEKACRDVDECLQGRC-EQVCVNSPGSYTCHCDGRGGLKLSQDMDTCED 279
C C G+ + ++ + C D++EC C C N+ GS+ C C G KLS C D
Sbjct: 835 CTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECS--PGSKLSSTGLICID 892
Query: 280 IL 281
L
Sbjct: 893 SL 894
Score = 113 bits (282), Expect = 7e-25
Identities = 66/177 (37%), Positives = 90/177 (50%), Gaps = 20/177 (11%)
Query: 118 DQCT--PNPCDRKGTQACQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQIC 171
D+C PN C C + MG+F C CK G+ G C D++ECSQ C IC
Sbjct: 2451 DECKVMPNLCTNG---QCINTMGSFRCFCKVGYTTDISGTSCI-DLDECSQSPKPCNYIC 2506
Query: 172 HNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSS 231
N GS+ CSC G+ L DG+TC+D+DEC + + C N G ++C C GF +
Sbjct: 2507 KNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGF--TQ 2564
Query: 232 QEKACRDVDEC-----LQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
AC D +EC L G + +C N+PGS++C C + G L CED+ C
Sbjct: 2565 HHTACIDNNECGSQPSLCG-AKGICQNTPGSFSCEC--QRGFSLDATGLNCEDVDEC 2618
Score = 109 bits (273), Expect = 7e-24
Identities = 63/173 (36%), Positives = 84/173 (48%), Gaps = 10/173 (5%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGWG---GRLCDKDVNECSQENGGCLQ-ICHN 173
D+C NP +G C + G+F C C G R D+NECS + C C N
Sbjct: 1160 DECERNPLLCRGG-TCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVN 1218
Query: 174 KPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQE 233
G++ CSC+ G++ + D + C DIDEC + +C N GSY C C EG+A
Sbjct: 1219 MIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDG 1278
Query: 234 KACRDVDECLQGR--CE-QVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
++C D+DEC C+ C N PG Y C C G S DM TC D+ C
Sbjct: 1279 RSCADIDECENNPDICDGGQCTNIPGEYRCLC--YDGFMASMDMKTCIDVNEC 1329
Score = 108 bits (270), Expect = 2e-23
Identities = 63/179 (35%), Positives = 82/179 (45%), Gaps = 15/179 (8%)
Query: 95 CINKYGSPYTK-NSGFA----TCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWG 149
C+N G K GF C+ N P+ C KG CQ+ G+F C C+ G+
Sbjct: 2547 CVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGI--CQNTPGSFSCECQRGFS 2604
Query: 150 ----GRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSE 205
G C+ DV+EC N C C N G + C C G+ C D +EC++
Sbjct: 2605 LDATGLNCE-DVDECDG-NHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPN 2662
Query: 206 ACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGR--CEQVCVNSPGSYTCHC 262
ACG A C N GSY C C GF++ AC DV+EC + C C N+ G Y C C
Sbjct: 2663 ACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGC 2721
Score = 105 bits (263), Expect = 1e-22
Identities = 70/201 (34%), Positives = 98/201 (48%), Gaps = 20/201 (9%)
Query: 95 CINKYGSPYTKNSGFATCVQNLPDQCT--PNPCDRKGTQACQDLMGNFFCLCKAGWGGR- 151
C N G + ++G A + D+C P C C + +G+F C C G+
Sbjct: 1791 CGNIPGFTFDIHTGKAVDI----DECKEIPGIC---ANGVCINQIGSFRCECPTGFSYND 1843
Query: 152 --LCDKDVNECSQENGGCLQI--CHNKPGSFHCSCHSGFELSSDGRTCQDIDECAD-SEA 206
L +D++ECS + C + C N PGS+ C C +GF+LS +G C D +EC +
Sbjct: 1844 LLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNV 1902
Query: 207 CGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRC-EQVCVNSPGSYTCHCDGR 265
C C +L GSY C+C GF S + C DVDEC + C C N+ GSY C C
Sbjct: 1903 CSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLC--Y 1960
Query: 266 GGLKLSQDMDTCEDILPCVPF 286
G +L+ + D C DI C F
Sbjct: 1961 PGFELTHNND-CLDIDECSSF 1980
Score = 102 bits (255), Expect = 9e-22
Identities = 67/174 (38%), Positives = 82/174 (47%), Gaps = 24/174 (13%)
Query: 125 CDRKGTQACQDLMGNFFCLCKAGWG---------GRLCDKDVNECSQENGGCLQ-ICHNK 174
C + GT+ + LC G G GR KD+NEC G C C N
Sbjct: 1040 CPKPGTK-------EYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNT 1092
Query: 175 PGSFHCSCHSGFELSSDGRTCQDIDECADS-EACGEARCKNLPGSYSCLCDEGFAYS-SQ 232
GSF C C+SGF L + R C DIDEC S + CG C N PGS+ C C EG+
Sbjct: 1093 IGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMM 1152
Query: 233 EKACRDVDECLQG--RCE-QVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
K C D+DEC + C CVN+ GS+ C C G +LS + C DI C
Sbjct: 1153 MKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCP--LGHELSPSREDCVDINEC 1204
Score = 100 bits (250), Expect = 3e-21
Identities = 65/182 (35%), Positives = 84/182 (46%), Gaps = 20/182 (10%)
Query: 112 CVQNLPDQCTPNPCD---RKGTQACQDLMGNFFCLCKAGWGG--RLCD--KDVNECSQEN 164
C +P + +PC+ + A QDL C G G L D +DVNEC +
Sbjct: 2127 CCSKMPGEGWGDPCELCPKDDEVAFQDL-------CPYGHGTVPSLHDTREDVNECLESP 2179
Query: 165 GGCLQ-ICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLC 223
G C C N GSF C C G+ L G C D DEC+ CG C N+ GS+ C C
Sbjct: 2180 GICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNC 2239
Query: 224 DEGFAYSSQEKACRDVDECLQG--RCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDIL 281
+EGF C D++EC Q C C+N+ GSY C C G L +D C+D+
Sbjct: 2240 NEGFEPGPMMN-CEDINECAQNPLLCAFRCMNTFGSYECTCP--IGYALREDQKMCKDLD 2296
Query: 282 PC 283
C
Sbjct: 2297 EC 2298
Score = 99.0 bits (245), Expect = 1e-20
Identities = 59/171 (34%), Positives = 88/171 (51%), Gaps = 17/171 (9%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGWG---GRLCDKDVNECSQENGGCLQI--CH 172
D+C +PC G C++ +G++ CLC G+ C D++ECS G + C
Sbjct: 1936 DECERHPC---GNGTCKNTVGSYNCLCYPGFELTHNNDC-LDIDECSSFFGQVCRNGRCF 1991
Query: 173 NKPGSFHCSCHSGFELSSDGRTCQDIDEC-ADSEACGEARCKNLPGSYSCLCDEGFAYSS 231
N+ GSF C C+ G+EL+ DG+ C D +EC A +C C+NL GS+ C+C G+ S
Sbjct: 1992 NEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKS 2051
Query: 232 QEKACRDVDECLQGR---CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCED 279
+ C D++EC + C N+PG + C C G LS + C D
Sbjct: 2052 EN--CIDINECDEDPNICLFGSCTNTPGGFQCLCP--PGFVLSDNGRRCFD 2098
Score = 95.9 bits (237), Expect = 1e-19
Identities = 61/200 (30%), Positives = 86/200 (43%), Gaps = 54/200 (27%)
Query: 133 CQDLMGNFFCLCKAGWGG---RLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELS 189
C +++G + C C G+ R D++EC NGGC C N GS+ CSC G+ L
Sbjct: 1216 CVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALM 1275
Query: 190 SDGRTCQDIDECADS-EACGEARCKNLP-------------------------------- 216
DGR+C DIDEC ++ + C +C N+P
Sbjct: 1276 PDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNI 1335
Query: 217 ----------GSYSCLCDEGFAYSSQEKACRDVDECLQG--RCEQ--VCVNSPGSYTCHC 262
GS+ C C G++ C DVDEC G C+ C+N PGS+ C C
Sbjct: 1336 CMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSC 1395
Query: 263 -DG--RGGLKLSQDMDTCED 279
+G G+K D+D C +
Sbjct: 1396 REGWIGNGIKCI-DLDECSN 1414
Score = 93.6 bits (231), Expect = 5e-19
Identities = 58/160 (36%), Positives = 77/160 (48%), Gaps = 13/160 (8%)
Query: 133 CQDLMGNFFCLCKAGWG----GRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFEL 188
C + G+F C C G+ G C D +ECS N C N GSF C+C+ GFE
Sbjct: 2187 CINTDGSFRCECPMGYNLDYTGVRC-VDTDECSIGNPCGNGTCTNVIGSFECNCNEGFE- 2244
Query: 189 SSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQG--R 246
C+DI+ECA + RC N GSY C C G+A +K C+D+DEC +G
Sbjct: 2245 PGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHD 2304
Query: 247 CE---QVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
CE +C N G++ C C G+ D + C D C
Sbjct: 2305 CESRGMMCKNLIGTFMCICP--PGMARRPDGEGCVDENEC 2342
Score = 87.8 bits (216), Expect = 3e-17
Identities = 47/125 (37%), Positives = 61/125 (48%), Gaps = 6/125 (4%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQICHN 173
D+C N + Q C ++ G + C C+ G+ R C +D++ECS +N C+N
Sbjct: 1451 DECAENINLCENGQ-CLNVPGAYRCECEMGFTPASDSRSC-QDIDECSFQNICVFGTCNN 1508
Query: 174 KPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQE 233
PG FHC C G+EL G C DIDECAD C C N PG Y C C F +
Sbjct: 1509 LPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTG 1568
Query: 234 KACRD 238
C D
Sbjct: 1569 VGCVD 1573
Score = 85.5 bits (210), Expect = 1e-16
Identities = 70/236 (29%), Positives = 92/236 (38%), Gaps = 68/236 (28%)
Query: 95 CINKYGS-------PYTKNSGFATCVQNLPDQCT-PNPCDRKGTQACQDLMGNFFCLCKA 146
CIN GS Y + CV D+C+ NPC G C +++G+F C C
Sbjct: 2187 CINTDGSFRCECPMGYNLDYTGVRCVDT--DECSIGNPC---GNGTCTNVIGSFECNCNE 2241
Query: 147 GW--GGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECA-- 202
G+ G + +D+NEC+Q C C N GS+ C+C G+ L D + C+D+DECA
Sbjct: 2242 GFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEG 2301
Query: 203 ------------------------------DSEACGE-------------ARCKNLPGSY 219
D E C + RC N+ GSY
Sbjct: 2302 LHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSY 2361
Query: 220 SCLCDEGFAYSSQEKACRD------VDECLQGRCEQVCV--NSPGSYTCHCDGRGG 267
C C+EGF SS C D E LQ C+ N C CDG G
Sbjct: 2362 RCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRG 2417
Score = 74.3 bits (181), Expect = 3e-13
Identities = 69/245 (28%), Positives = 99/245 (40%), Gaps = 39/245 (15%)
Query: 65 CVEELCSREEAREVFE-NDPETDYFYPRYLDCI-NKYGSPYTK-----------NSGFAT 111
CV LC R +E N P P + C+ N+ G+ Y K N+
Sbjct: 1542 CVNGLCVNTPGR--YECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGV 1599
Query: 112 CVQNLPDQCT-----PNPCDRKGTQACQDLMGN-FFCLCKAGWGGR-----LCDKDVNEC 160
V C+ NPC+ C + ++ LC G G R + +D++EC
Sbjct: 1600 GVSRSSCCCSLGKAWGNPCE-----TCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDEC 1654
Query: 161 SQENGGCLQ-ICHNKPGSFHCSCHSGFELSSDGRTCQDIDEC-ADSEACGEARCKNLPGS 218
+ G C C N GSF C C G+ LS D R C+DIDEC A CG C N G+
Sbjct: 1655 QELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGN 1714
Query: 219 YSCLCDEGFAYSSQEKACRDVDE--CLQGRCEQVCVNS-PGSYT---CHCDGRGGLKLSQ 272
Y+C+C + + C D+ + C + C N P + T C C G ++
Sbjct: 1715 YTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNK 1774
Query: 273 DMDTC 277
+ C
Sbjct: 1775 PCEPC 1779
Score = 71.6 bits (174), Expect = 2e-12
Identities = 56/203 (27%), Positives = 82/203 (40%), Gaps = 40/203 (19%)
Query: 118 DQCTP--NPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDK---DVNECSQENGGCLQ-IC 171
D+C + C+ +G C++L+G F C+C G R + D NEC + G C C
Sbjct: 2296 DECAEGLHDCESRGMM-CKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRC 2354
Query: 172 HNKPGSFHCSCHSGFELSSDGRTCQD------IDECADSEACGEARCKNLPGSYSCLCDE 225
N GS+ C C+ GF+ SS G C D E + + +NL C CD
Sbjct: 2355 VNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDG 2414
Query: 226 GFAYSSQEKAC----------------------RDVDEC--LQGRCEQ-VCVNSPGSYTC 260
G + Q + C RD+DEC + C C+N+ GS+ C
Sbjct: 2415 GRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRC 2474
Query: 261 HCDGRGGLKLSQDMDTCEDILPC 283
C + G +C D+ C
Sbjct: 2475 FC--KVGYTTDISGTSCIDLDEC 2495
Score = 70.5 bits (171), Expect = 5e-12
Identities = 38/114 (33%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQICHN 173
D+C N + G CQ+++G + C C G+ C D NECS N C+N
Sbjct: 2616 DECDGNHRCQHG---CQNILGGYRCGCPQGYIQHYQWNQC-VDENECSNPNACGSASCYN 2671
Query: 174 KPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGF 227
GS+ C+C SGF C D++EC+ S+ C N G Y C C G+
Sbjct: 2672 TLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGY 2725
Score = 67.4 bits (163), Expect = 4e-11
Identities = 39/117 (33%), Positives = 51/117 (43%), Gaps = 8/117 (6%)
Query: 155 KDVNECSQENGGCLQ-ICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEA-CGEARC 212
+DV+EC G C C N GSF C C +G + S + C+DIDEC+ C C
Sbjct: 275 QDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGEC 334
Query: 213 KNLPGSYSCLCDEGFAYSSQEKACRD------VDECLQGRCEQVCVNSPGSYTCHCD 263
N GSY C+C G+ S+ C D + GRC Q C C+
Sbjct: 335 SNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCE 391
Score = 67.4 bits (163), Expect = 4e-11
Identities = 55/195 (28%), Positives = 76/195 (38%), Gaps = 48/195 (24%)
Query: 133 CQDLMGNFFCLCKAGW-----GGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFE 187
C +L G F C+C G+ GG D ++EC+ +C N PG + C+C F+
Sbjct: 1506 CNNLPGMFHCICDDGYELDRTGGNCTD--IDECADPINCVNGLCVNTPGRYECNCPPDFQ 1563
Query: 188 LSSDGRTCQD--IDECA---DSEACGEARCKNLPG----SYSCLCDEGFAYSSQEKAC-- 236
L+ G C D + C G C G SC C G A+ + + C
Sbjct: 1564 LNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPP 1623
Query: 237 -------------------------RDVDEC--LQGRCEQV-CVNSPGSYTCHCDGRGGL 268
D+DEC L G C+ C+N+ GS+ C C G
Sbjct: 1624 VNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQ--GY 1681
Query: 269 KLSQDMDTCEDILPC 283
LS+D CEDI C
Sbjct: 1682 YLSEDTRICEDIDEC 1696
Score = 62.4 bits (150), Expect = 1e-09
Identities = 52/168 (30%), Positives = 66/168 (39%), Gaps = 41/168 (24%)
Query: 155 KDVNECSQENGGCLQ-ICHNKPGSFHCSCHSGFELSSDGRTCQDI-----------DECA 202
+DVNEC G C C N GSFHC C G L GR C DI DEC
Sbjct: 954 EDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECI 1013
Query: 203 D-------SEAC----GEA---RCKNLP----GSYSCLCDEGFAYSSQEKAC------RD 238
+AC G A C+ P Y LC G ++++ +D
Sbjct: 1014 HPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKD 1073
Query: 239 VDEC--LQGRCEQ-VCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
++EC G C C N+ GS+ C C+ G L + C DI C
Sbjct: 1074 INECKAFPGMCTYGKCRNTIGSFKCRCN--SGFALDMEERNCTDIDEC 1119
Score = 59.3 bits (142), Expect = 1e-08
Identities = 59/222 (26%), Positives = 79/222 (35%), Gaps = 47/222 (21%)
Query: 95 CINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQ------DLMGNFFCLCKAGW 148
C N G + TC + C K Q C + C C+ G+
Sbjct: 115 CRNSCGDGFCSRPNMCTCSSGQ----ISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGY 170
Query: 149 GGRLCDKDVNECSQENGG-CLQICHNKPGSFHCSCHSGF---ELSSDGRT---------- 194
G C + V E +NGG C+ G C+C GF + D RT
Sbjct: 171 IGTYCGQPVCENGCQNGGRCI-------GPNRCACVYGFTGPQCERDYRTGPCFTQVNNQ 223
Query: 195 ----------CQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDEC-- 242
C CA C+ P C GF + + AC+DVDEC
Sbjct: 224 MCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQP-CRRGFIPNIRTGACQDVDECQA 282
Query: 243 LQGRCE-QVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
+ G C+ C+N+ GS+ C C G K S+ CEDI C
Sbjct: 283 IPGICQGGNCINTVGSFECRCP--AGHKQSETTQKCEDIDEC 322
Score = 55.5 bits (132), Expect = 2e-07
Identities = 33/91 (36%), Positives = 41/91 (45%), Gaps = 5/91 (5%)
Query: 196 QDIDECAD-SEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQ-VCVN 253
Q ID C + C RC SY C C+ G+ + C DVDEC C CVN
Sbjct: 493 QTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGD-CIDVDECTSNPCTNGDCVN 551
Query: 254 SPGSYTCHCDGRGGLKLSQDMDTCEDILPCV 284
+PGSY C C G + + C DI C+
Sbjct: 552 TPGSYYCKC--HAGFQRTPTKQACIDIDECI 580
Score = 50.1 bits (118), Expect = 7e-06
Identities = 46/178 (25%), Positives = 70/178 (39%), Gaps = 37/178 (20%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGWG----GRLCDKDV----------NECSQE 163
++C NPC AC++ +G+F C C G G +C + + C
Sbjct: 854 NECESNPCVNG---ACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVN 910
Query: 164 -NGGCL--QICHNKPGSFHCSCHSGFELSS---------DGRTCQDIDEC-ADSEACGEA 210
NG L + C ++ C EL + G TC+D++EC C
Sbjct: 911 INGATLKSECCATLGAAWGSPCER-CELDTACPRGLARIKGVTCEDVNECEVFPGVCPNG 969
Query: 211 RCKNLPGSYSCLCDEGFAYSSQEKACRDV--DECLQGRCEQVCVNS-PGSY---TCHC 262
RC N GS+ C C EG + C D+ ++C E C++ PG + C C
Sbjct: 970 RCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCC 1027
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 120 bits (302), Expect = 3e-27
Identities = 65/174 (37%), Positives = 94/174 (54%), Gaps = 15/174 (8%)
Query: 118 DQCT-PNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCD----KDVNECSQENGGCLQICH 172
D+C PN C C +L G++ C C G+ R D +D++EC Q N C
Sbjct: 1041 DECLEPNVC---ANGDCSNLEGSYMCSCHKGYT-RTPDHKHCRDIDECQQGNLCVNGQCK 1096
Query: 173 NKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQ 232
N GSF C+C G++LS+ C+DIDEC C +C+N GS+ C+CD+G+ S
Sbjct: 1097 NTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGL 1156
Query: 233 EKACRDVDECLQGR--CEQ-VCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
C D++ECL+ + C++ C+N+ GSY C C G +L D TC+DI C
Sbjct: 1157 GDHCEDINECLEDKSVCQRGDCINTAGSYDCTCP--DGFQL-DDNKTCQDINEC 1207
Score = 112 bits (280), Expect = 1e-24
Identities = 62/174 (35%), Positives = 88/174 (50%), Gaps = 14/174 (8%)
Query: 118 DQC-TPNPCDRKGTQACQDLMGNFFCL-CKAG---WGGRLCDKDVNECSQENGGCLQICH 172
D+C P+ C + C + G++ C+ C G W G+ D V+EC + N C
Sbjct: 1001 DECLNPSTCP---DEQCVNSPGSYQCVPCTEGFRGWNGQCLD--VDECLEPNVCANGDCS 1055
Query: 173 NKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQ 232
N GS+ CSCH G+ + D + C+DIDEC C +CKN GS+ C C +G+ S+
Sbjct: 1056 NLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAA 1115
Query: 233 EKACRDVDECLQGR--CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCV 284
+ C D+DEC C N+ GS+ C CD G + S D CEDI C+
Sbjct: 1116 KDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCD--QGYRASGLGDHCEDINECL 1167
Score = 109 bits (273), Expect = 7e-24
Identities = 62/151 (41%), Positives = 82/151 (54%), Gaps = 11/151 (7%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGWG----GRLCDKDVNECSQENGGCLQ-ICH 172
++CT NP D G C +L + C+C G+ R C D++EC+Q C Q C
Sbjct: 876 NECTVNP-DICGAGHCINLPVRYTCICYEGYRFSEQQRKC-VDIDECTQVQHLCSQGRCE 933
Query: 173 NKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSC-LCDEGFAYSS 231
N GSF C C +GF S +G C D+DEC + CGE C N G++ C CD G+ +
Sbjct: 934 NTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYR-MT 992
Query: 232 QEKACRDVDECLQ-GRC-EQVCVNSPGSYTC 260
Q C D+DECL C ++ CVNSPGSY C
Sbjct: 993 QRGRCEDIDECLNPSTCPDEQCVNSPGSYQC 1023
Score = 107 bits (267), Expect = 4e-23
Identities = 57/138 (41%), Positives = 74/138 (53%), Gaps = 9/138 (6%)
Query: 133 CQDLMGNFFCLCKAGW---GGRLCDKDVNECSQEN-GGCLQICHNKPGSFHCSCHSGFEL 188
C + G++ C C G+ + C +D+NEC G C N GSFHC C GF +
Sbjct: 1178 CINTAGSYDCTCPDGFQLDDNKTC-QDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSI 1236
Query: 189 SSDGRTCQDIDECADSEAC-GEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDEC--LQG 245
S+DGRTC+DIDEC ++ C C N GS+ CLC +GF + C DV+EC L G
Sbjct: 1237 SADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSG 1296
Query: 246 RC-EQVCVNSPGSYTCHC 262
C E C N GS+ C C
Sbjct: 1297 VCGEAFCENVEGSFLCVC 1314
Score = 98.6 bits (244), Expect = 2e-20
Identities = 62/160 (38%), Positives = 83/160 (51%), Gaps = 16/160 (10%)
Query: 133 CQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQICHNKPGSFHCS-CHSGFE 187
C++ G+F C+C AG+ G C DV+EC + + C N G+F C C SG+
Sbjct: 932 CENTEGSFLCICPAGFMASEEGTNCI-DVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYR 990
Query: 188 LSSDGRTCQDIDECADSEACGEARCKNLPGSYSCL-CDEGF-AYSSQEKACRDVDECLQG 245
++ GR C+DIDEC + C + +C N PGSY C+ C EGF ++ Q C DVDECL+
Sbjct: 991 MTQRGR-CEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ---CLDVDECLEP 1046
Query: 246 R--CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
C N GSY C C G + D C DI C
Sbjct: 1047 NVCANGDCSNLEGSYMCSC--HKGYTRTPDHKHCRDIDEC 1084
Score = 61.2 bits (147), Expect = 3e-09
Identities = 52/182 (28%), Positives = 67/182 (36%), Gaps = 35/182 (19%)
Query: 72 REEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQ 131
+EE +E + N + C N TK T D C PC GT
Sbjct: 1344 KEEKKECYYNLNDASL-------CDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGT- 1395
Query: 132 ACQDLMGNFFCLCKAGWG-----------GRLCDKDVNEC---SQE---NGGCLQICHNK 174
F +C G G G KD +EC QE NG CL + +
Sbjct: 1396 ------AEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCL---NTR 1446
Query: 175 PGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEK 234
PG + C C G C D+DEC D +C + +C N GSY+C C + EK
Sbjct: 1447 PG-YECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEK 1505
Query: 235 AC 236
C
Sbjct: 1506 RC 1507
Score = 56.6 bits (135), Expect = 7e-08
Identities = 29/91 (31%), Positives = 44/91 (48%), Gaps = 10/91 (10%)
Query: 157 VNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECAD----SEACGEARC 212
+N C ENG C+++ + C C G+ L + TC D++EC + C A+C
Sbjct: 1629 LNGC--ENGRCVRVQEG----YTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKC 1682
Query: 213 KNLPGSYSCLCDEGFAYSSQEKACRDVDECL 243
N GSY CLC G+ S + C ++ L
Sbjct: 1683 INTDGSYKCLCLPGYVPSDKPNYCTPLNTAL 1713
Score = 53.1 bits (126), Expect = 8e-07
Identities = 28/75 (37%), Positives = 34/75 (45%), Gaps = 4/75 (5%)
Query: 192 GRTCQDIDECA--DSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQ-GRC- 247
G +D DEC E C C N Y C C +G Y + C D+DEC C
Sbjct: 1420 GENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCI 1479
Query: 248 EQVCVNSPGSYTCHC 262
+ CVN+ GSY C C
Sbjct: 1480 DGQCVNTEGSYNCFC 1494
Score = 48.9 bits (115), Expect = 2e-05
Identities = 24/70 (34%), Positives = 35/70 (50%), Gaps = 6/70 (8%)
Query: 199 DECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDEC--LQGR---CEQV-CV 252
+EC C RC + Y+C C +G+ + + C DV+EC L R C+ C+
Sbjct: 1624 EECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCI 1683
Query: 253 NSPGSYTCHC 262
N+ GSY C C
Sbjct: 1684 NTDGSYKCLC 1693
Score = 42.0 bits (97), Expect = 0.002
Identities = 25/73 (34%), Positives = 32/73 (43%), Gaps = 7/73 (9%)
Query: 169 QICHNKPGSFH-----CSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLC 223
Q C KP S+H C G++ ++ CQDI+EC C C N GSY C C
Sbjct: 595 QKCPKKP-SYHGYNQMMECLPGYKRVNN-TFCQDINECQLQGVCPNGECLNTMGSYRCTC 652
Query: 224 DEGFAYSSQEKAC 236
GF +C
Sbjct: 653 KIGFGPDPTFSSC 665
Score = 33.5 bits (75), Expect = 0.66
Identities = 15/29 (51%), Positives = 20/29 (68%), Gaps = 2/29 (6%)
Query: 236 CRDVDEC-LQGRCEQ-VCVNSPGSYTCHC 262
C+D++EC LQG C C+N+ GSY C C
Sbjct: 624 CQDINECQLQGVCPNGECLNTMGSYRCTC 652
Score = 30.0 bits (66), Expect = 7.3
Identities = 27/102 (26%), Positives = 36/102 (35%), Gaps = 17/102 (16%)
Query: 123 NPCDRKGT---QACQDLMGNFFCLCKAGWGG----RLCDKDVNECSQENGGCLQICHN-- 173
N C +G C + MG++ C CK G+G C D S+E G C ++ +
Sbjct: 628 NECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGR 687
Query: 174 ---KPGSFH-----CSCHSGFELSSDGRTCQDIDECADSEAC 207
P S H C C G C A E C
Sbjct: 688 QCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEIC 729
Score = 30.0 bits (66), Expect = 7.3
Identities = 21/80 (26%), Positives = 32/80 (40%), Gaps = 7/80 (8%)
Query: 133 CQDLMGNFFCLCKAGWG---GRLCDKDVNECSQENGG---CLQI-CHNKPGSFHCSCHSG 185
C + + C C G+ ++ DVNEC + N C C N GS+ C C G
Sbjct: 1637 CVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPG 1696
Query: 186 FELSSDGRTCQDIDECADSE 205
+ S C ++ + E
Sbjct: 1697 YVPSDKPNYCTPLNTALNLE 1716
>gi|46249412 latent transforming growth factor beta binding protein
1 isoform LTBP-1S [Homo sapiens]
Length = 1396
Score = 120 bits (302), Expect = 3e-27
Identities = 65/174 (37%), Positives = 94/174 (54%), Gaps = 15/174 (8%)
Query: 118 DQCT-PNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCD----KDVNECSQENGGCLQICH 172
D+C PN C C +L G++ C C G+ R D +D++EC Q N C
Sbjct: 715 DECLEPNVC---ANGDCSNLEGSYMCSCHKGYT-RTPDHKHCRDIDECQQGNLCVNGQCK 770
Query: 173 NKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQ 232
N GSF C+C G++LS+ C+DIDEC C +C+N GS+ C+CD+G+ S
Sbjct: 771 NTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGL 830
Query: 233 EKACRDVDECLQGR--CEQ-VCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
C D++ECL+ + C++ C+N+ GSY C C G +L D TC+DI C
Sbjct: 831 GDHCEDINECLEDKSVCQRGDCINTAGSYDCTCP--DGFQL-DDNKTCQDINEC 881
Score = 112 bits (280), Expect = 1e-24
Identities = 62/174 (35%), Positives = 88/174 (50%), Gaps = 14/174 (8%)
Query: 118 DQC-TPNPCDRKGTQACQDLMGNFFCL-CKAG---WGGRLCDKDVNECSQENGGCLQICH 172
D+C P+ C + C + G++ C+ C G W G+ D V+EC + N C
Sbjct: 675 DECLNPSTCP---DEQCVNSPGSYQCVPCTEGFRGWNGQCLD--VDECLEPNVCANGDCS 729
Query: 173 NKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQ 232
N GS+ CSCH G+ + D + C+DIDEC C +CKN GS+ C C +G+ S+
Sbjct: 730 NLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAA 789
Query: 233 EKACRDVDECLQGR--CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCV 284
+ C D+DEC C N+ GS+ C CD G + S D CEDI C+
Sbjct: 790 KDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCD--QGYRASGLGDHCEDINECL 841
Score = 109 bits (273), Expect = 7e-24
Identities = 62/151 (41%), Positives = 82/151 (54%), Gaps = 11/151 (7%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGWG----GRLCDKDVNECSQENGGCLQ-ICH 172
++CT NP D G C +L + C+C G+ R C D++EC+Q C Q C
Sbjct: 550 NECTVNP-DICGAGHCINLPVRYTCICYEGYRFSEQQRKC-VDIDECTQVQHLCSQGRCE 607
Query: 173 NKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSC-LCDEGFAYSS 231
N GSF C C +GF S +G C D+DEC + CGE C N G++ C CD G+ +
Sbjct: 608 NTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYR-MT 666
Query: 232 QEKACRDVDECLQ-GRC-EQVCVNSPGSYTC 260
Q C D+DECL C ++ CVNSPGSY C
Sbjct: 667 QRGRCEDIDECLNPSTCPDEQCVNSPGSYQC 697
Score = 107 bits (267), Expect = 4e-23
Identities = 57/138 (41%), Positives = 74/138 (53%), Gaps = 9/138 (6%)
Query: 133 CQDLMGNFFCLCKAGW---GGRLCDKDVNECSQEN-GGCLQICHNKPGSFHCSCHSGFEL 188
C + G++ C C G+ + C +D+NEC G C N GSFHC C GF +
Sbjct: 852 CINTAGSYDCTCPDGFQLDDNKTC-QDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSI 910
Query: 189 SSDGRTCQDIDECADSEAC-GEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDEC--LQG 245
S+DGRTC+DIDEC ++ C C N GS+ CLC +GF + C DV+EC L G
Sbjct: 911 SADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSG 970
Query: 246 RC-EQVCVNSPGSYTCHC 262
C E C N GS+ C C
Sbjct: 971 VCGEAFCENVEGSFLCVC 988
Score = 98.6 bits (244), Expect = 2e-20
Identities = 62/160 (38%), Positives = 83/160 (51%), Gaps = 16/160 (10%)
Query: 133 CQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQICHNKPGSFHCS-CHSGFE 187
C++ G+F C+C AG+ G C DV+EC + + C N G+F C C SG+
Sbjct: 606 CENTEGSFLCICPAGFMASEEGTNCI-DVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYR 664
Query: 188 LSSDGRTCQDIDECADSEACGEARCKNLPGSYSCL-CDEGF-AYSSQEKACRDVDECLQG 245
++ GR C+DIDEC + C + +C N PGSY C+ C EGF ++ Q C DVDECL+
Sbjct: 665 MTQRGR-CEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ---CLDVDECLEP 720
Query: 246 R--CEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
C N GSY C C G + D C DI C
Sbjct: 721 NVCANGDCSNLEGSYMCSC--HKGYTRTPDHKHCRDIDEC 758
Score = 61.2 bits (147), Expect = 3e-09
Identities = 52/182 (28%), Positives = 67/182 (36%), Gaps = 35/182 (19%)
Query: 72 REEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQ 131
+EE +E + N + C N TK T D C PC GT
Sbjct: 1018 KEEKKECYYNLNDASL-------CDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGT- 1069
Query: 132 ACQDLMGNFFCLCKAGWG-----------GRLCDKDVNEC---SQE---NGGCLQICHNK 174
F +C G G G KD +EC QE NG CL + +
Sbjct: 1070 ------AEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCL---NTR 1120
Query: 175 PGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEK 234
PG + C C G C D+DEC D +C + +C N GSY+C C + EK
Sbjct: 1121 PG-YECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEK 1179
Query: 235 AC 236
C
Sbjct: 1180 RC 1181
Score = 56.6 bits (135), Expect = 7e-08
Identities = 29/91 (31%), Positives = 44/91 (48%), Gaps = 10/91 (10%)
Query: 157 VNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECAD----SEACGEARC 212
+N C ENG C+++ + C C G+ L + TC D++EC + C A+C
Sbjct: 1303 LNGC--ENGRCVRVQEG----YTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKC 1356
Query: 213 KNLPGSYSCLCDEGFAYSSQEKACRDVDECL 243
N GSY CLC G+ S + C ++ L
Sbjct: 1357 INTDGSYKCLCLPGYVPSDKPNYCTPLNTAL 1387
Score = 53.1 bits (126), Expect = 8e-07
Identities = 28/75 (37%), Positives = 34/75 (45%), Gaps = 4/75 (5%)
Query: 192 GRTCQDIDECA--DSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQ-GRC- 247
G +D DEC E C C N Y C C +G Y + C D+DEC C
Sbjct: 1094 GENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCI 1153
Query: 248 EQVCVNSPGSYTCHC 262
+ CVN+ GSY C C
Sbjct: 1154 DGQCVNTEGSYNCFC 1168
Score = 48.9 bits (115), Expect = 2e-05
Identities = 24/70 (34%), Positives = 35/70 (50%), Gaps = 6/70 (8%)
Query: 199 DECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDEC--LQGR---CEQV-CV 252
+EC C RC + Y+C C +G+ + + C DV+EC L R C+ C+
Sbjct: 1298 EECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCI 1357
Query: 253 NSPGSYTCHC 262
N+ GSY C C
Sbjct: 1358 NTDGSYKCLC 1367
Score = 42.0 bits (97), Expect = 0.002
Identities = 25/73 (34%), Positives = 32/73 (43%), Gaps = 7/73 (9%)
Query: 169 QICHNKPGSFH-----CSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLC 223
Q C KP S+H C G++ ++ CQDI+EC C C N GSY C C
Sbjct: 269 QKCPKKP-SYHGYNQMMECLPGYKRVNN-TFCQDINECQLQGVCPNGECLNTMGSYRCTC 326
Query: 224 DEGFAYSSQEKAC 236
GF +C
Sbjct: 327 KIGFGPDPTFSSC 339
Score = 33.5 bits (75), Expect = 0.66
Identities = 15/29 (51%), Positives = 20/29 (68%), Gaps = 2/29 (6%)
Query: 236 CRDVDEC-LQGRCEQ-VCVNSPGSYTCHC 262
C+D++EC LQG C C+N+ GSY C C
Sbjct: 298 CQDINECQLQGVCPNGECLNTMGSYRCTC 326
Score = 30.0 bits (66), Expect = 7.3
Identities = 27/102 (26%), Positives = 36/102 (35%), Gaps = 17/102 (16%)
Query: 123 NPCDRKGT---QACQDLMGNFFCLCKAGWGG----RLCDKDVNECSQENGGCLQICHN-- 173
N C +G C + MG++ C CK G+G C D S+E G C ++ +
Sbjct: 302 NECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGR 361
Query: 174 ---KPGSFH-----CSCHSGFELSSDGRTCQDIDECADSEAC 207
P S H C C G C A E C
Sbjct: 362 QCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEIC 403
Score = 30.0 bits (66), Expect = 7.3
Identities = 21/80 (26%), Positives = 32/80 (40%), Gaps = 7/80 (8%)
Query: 133 CQDLMGNFFCLCKAGWG---GRLCDKDVNECSQENGG---CLQI-CHNKPGSFHCSCHSG 185
C + + C C G+ ++ DVNEC + N C C N GS+ C C G
Sbjct: 1311 CVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPG 1370
Query: 186 FELSSDGRTCQDIDECADSE 205
+ S C ++ + E
Sbjct: 1371 YVPSDKPNYCTPLNTALNLE 1390
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 120 bits (302), Expect = 3e-27
Identities = 62/158 (39%), Positives = 82/158 (51%), Gaps = 13/158 (8%)
Query: 133 CQDLMGNFFCLCKAGW----GGRLCDKD----VNECSQENGGCLQICHNKPGSFHCSCHS 184
C + G+F C+C AG+ GR C + VN C NGGC C + C+C
Sbjct: 300 CLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPR 359
Query: 185 GFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECL- 243
G+EL +D RTC D+D+CADS C + C N PG Y C C G+ S+ C DVDEC
Sbjct: 360 GYELDTDQRTCIDVDDCADSPCCQQV-CTNNPGGYECGCYAGYRLSADGCGCEDVDECAS 418
Query: 244 -QGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDI 280
+G CE C N GS+ C C+ G +L +D C +
Sbjct: 419 SRGGCEHHCTNLAGSFQCSCE--AGYRLHEDRRGCSPL 454
Score = 97.4 bits (241), Expect = 4e-20
Identities = 56/193 (29%), Positives = 80/193 (41%), Gaps = 54/193 (27%)
Query: 142 CLCKAGW----GGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQD 197
C C+ G+ GR C + + C+ NG C+ C G C CH G++L++DG+ C+D
Sbjct: 227 CQCRPGFQLQEDGRHCVRR-SPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACED 285
Query: 198 IDECADSEACGEARCKNLPGSYSCL----------------------------------- 222
+DECA A C N GS+ C+
Sbjct: 286 VDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHG 345
Query: 223 -----------CDEGFAYSSQEKACRDVDECLQGR-CEQVCVNSPGSYTCHCDGRGGLKL 270
C G+ + ++ C DVD+C C+QVC N+PG Y C C G +L
Sbjct: 346 CSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGC--YAGYRL 403
Query: 271 SQDMDTCEDILPC 283
S D CED+ C
Sbjct: 404 SADGCGCEDVDEC 416
Score = 97.1 bits (240), Expect = 5e-20
Identities = 58/180 (32%), Positives = 73/180 (40%), Gaps = 46/180 (25%)
Query: 142 CLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDEC 201
C C G+ G C DV+EC NGGC C N PGS+ C C GF L +D RTC I+ C
Sbjct: 147 CHCPPGFQGPRCQYDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSC 206
Query: 202 A------------------------------DSEACGEA------------RCKNLPGSY 219
A D C RC+ + G
Sbjct: 207 ALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLA 266
Query: 220 SCLCDEGFAYSSQEKACRDVDECLQG--RCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTC 277
C C G+ ++ KAC DVDEC G +C C+N+ GS+ C C G +L D C
Sbjct: 267 RCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVC--HAGYELGADGRQC 324
Score = 89.7 bits (221), Expect = 8e-18
Identities = 42/126 (33%), Positives = 64/126 (50%), Gaps = 9/126 (7%)
Query: 123 NPCDRKG---TQACQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQICHNKP 175
N C+ + C C C G+ R C DV++C+ ++ C Q+C N P
Sbjct: 333 NSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCI-DVDDCA-DSPCCQQVCTNNP 390
Query: 176 GSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKA 235
G + C C++G+ LS+DG C+D+DECA S E C NL GS+ C C+ G+ +
Sbjct: 391 GGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRG 450
Query: 236 CRDVDE 241
C ++E
Sbjct: 451 CSPLEE 456
Score = 52.4 bits (124), Expect = 1e-06
Identities = 51/171 (29%), Positives = 68/171 (39%), Gaps = 33/171 (19%)
Query: 111 TCVQNLP-----DQCTPNP-CDRKGTQACQDLMGNFFCLCKAGWGGRLCDK-----DVNE 159
+C+Q P D C + C GT C + G+ C C GW G C+K DV
Sbjct: 1028 SCLQACPAGLYGDNCRHSCLCQNGGT--CDPVSGH--CACPEGWAGLACEKECLPRDVRA 1083
Query: 160 CSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECAD---SEACGEARCKNLP 216
+ +GGCL P + C C +G+ G CQ C EAC + RC P
Sbjct: 1084 GCRHSGGCLNGGLCDPHTGRCLCPAGW----TGDKCQ--SPCLRGWFGEACAQ-RCSCPP 1136
Query: 217 GSY------SCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCH 261
G+ +C C GF S E+AC C Q+C + CH
Sbjct: 1137 GAACHHVTGACRCPPGFTGSGCEQAC--PPGSFGEDCAQMCQCPGENPACH 1185
Score = 48.1 bits (113), Expect = 3e-05
Identities = 48/176 (27%), Positives = 67/176 (38%), Gaps = 31/176 (17%)
Query: 125 CDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPG------SF 178
C + TQ+C G+ C CKAG+ G C + E GC Q C G S
Sbjct: 656 CVQPHTQSCDKRDGS--CSCKAGFRGERCQAEC-ELGYFGPGCWQACTCPVGVACDSVSG 712
Query: 179 HCS--CHSGFELSSDGRTCQDID---ECADSEACGEARCKNLPGSYSCLCDEGFAYSSQE 233
C C +GF+ G+ C C+ S +CG A C + G C C G E
Sbjct: 713 ECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTG--QCRCPPGRTGEDCE 770
Query: 234 KACRDVDECLQGR----CEQVCVNSPGSYTCHCDGRGGLKLSQD---MDTCEDILP 282
+C +GR C+++C + CD G L C+D+ P
Sbjct: 771 A------DCPEGRWGLGCQEIC--PACQHAARCDPETGACLCLPGFVGSRCQDVCP 818
Score = 47.4 bits (111), Expect = 4e-05
Identities = 43/141 (30%), Positives = 54/141 (38%), Gaps = 32/141 (22%)
Query: 133 CQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDG 192
CQD+ C AGW G C CS N G H P + HCSC G+ S
Sbjct: 813 CQDV-------CPAGWYGPSCQ---TRCSCANDG-----HCHPATGHCSCAPGWTGFSCQ 857
Query: 193 RTCQD---IDECADSEAC--GEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGR- 246
R C +C+ C G C + G CLC+ G+ E+ +C QG
Sbjct: 858 RACDTGHWGPDCSHPCNCSAGHGSCDAISG--LCLCEAGYVGPRCEQ------QCPQGHF 909
Query: 247 ---CEQVCVNSPGSYTCHCDG 264
CEQ C G+ H G
Sbjct: 910 GPGCEQRCQCQHGAACDHVSG 930
Score = 46.6 bits (109), Expect = 8e-05
Identities = 47/169 (27%), Positives = 64/169 (37%), Gaps = 35/169 (20%)
Query: 121 TPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVN----------ECSQENGGCLQ- 169
T + C GT C L+G C C GW G +C++ CS +NGG
Sbjct: 523 TCDDCRNGGT--C--LLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDS 578
Query: 170 ---ICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEG 226
C PG +C G G+ C+ CA+ RC L G +CLCD G
Sbjct: 579 VTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCAN-----RGRCHRLYG--ACLCDPG 631
Query: 227 ----FAYSSQE-----KACRDVDECLQGRCEQVCVNSPGSYTCHCDGRG 266
F + + C + +C+Q Q C GS +C RG
Sbjct: 632 LYGRFCHLTCPPWAFGPGCSEECQCVQPH-TQSCDKRDGSCSCKAGFRG 679
Score = 43.5 bits (101), Expect = 6e-04
Identities = 45/178 (25%), Positives = 60/178 (33%), Gaps = 24/178 (13%)
Query: 112 CVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVN----------ECS 161
C QN + C + C G+ C C GW GR C+ ECS
Sbjct: 1292 CPQNRFGVGCEHTCSCRNGGLCHASNGS--CSCGLGWTGRHCELACPPGRYGAACHLECS 1349
Query: 162 QENGGCLQ----ICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACG--EARCKNL 215
N + C PG + +C G CQ + C C RC
Sbjct: 1350 CHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCP 1409
Query: 216 PGSYSCLCDEGFAYSSQEKACRDVDECLQGR-CEQV---CVNSPG--SYTCHCDGRGG 267
G + C+ G S + C +C G C+ V C+ PG TC+ D R G
Sbjct: 1410 AGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGATCNLDCRRG 1467
Score = 33.9 bits (76), Expect = 0.51
Identities = 48/189 (25%), Positives = 64/189 (33%), Gaps = 64/189 (33%)
Query: 92 YLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDR----KGTQA---------CQDLMG 138
+L+C S +G C Q +PC G Q C + G
Sbjct: 1345 HLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISG 1404
Query: 139 NFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDI 198
CLC AG+ G C++ GC +PGSF CH + C D
Sbjct: 1405 R--CLCPAGFHGHFCER----------GC------EPGSFGEGCH---------QRC-DC 1436
Query: 199 DECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSY 258
D G A C + G CLC G + ++ CR +G+ C
Sbjct: 1437 D--------GGAPCDPVTG--LCLCPPGRSGATCNLDCR------RGQFGPSC------- 1473
Query: 259 TCHCDGRGG 267
T HCD GG
Sbjct: 1474 TLHCDCGGG 1482
Score = 31.6 bits (70), Expect = 2.5
Identities = 43/166 (25%), Positives = 59/166 (35%), Gaps = 24/166 (14%)
Query: 125 CDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGG--CLQICHNKPGSF---- 178
C + AC + G C C AGW G C+ + C G C C+ G+
Sbjct: 917 CQCQHGAACDHVSGA--CTCPAGWRGTFCE---HACPAGFFGLDCRSACNCTAGAACDAV 971
Query: 179 --HCSCHSGFELSSDGRTCQDI---DECADSEAC-GEARCKNLPGSYSCLCDEGFAYSSQ 232
C C +G TC C+ + AC A C + G C C G+ S
Sbjct: 972 NGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHG--QCHCAPGWMGPSC 1029
Query: 233 EKACRD---VDECLQG-RCEQVCVNSPGSYTCHC-DGRGGLKLSQD 273
+AC D C C+ P S C C +G GL ++
Sbjct: 1030 LQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKE 1075
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 120 bits (301), Expect = 4e-27
Identities = 71/180 (39%), Positives = 96/180 (53%), Gaps = 19/180 (10%)
Query: 118 DQCTP--NPCDRKGTQACQDLMGNFFC-----LCKAGW----GGRLCDKDVNECSQENGG 166
++CT PC R G +C + +G++ C +C G+ G C DVNEC
Sbjct: 812 NECTSLSEPC-RPGF-SCINTVGSYTCQRNPLICARGYHASDDGTKC-VDVNECETGVHR 868
Query: 167 CL--QICHNKPGSFHCSCHSGFELSSDGRTCQDIDEC-ADSEACGEARCKNLPGSYSCLC 223
C Q+CHN PGS+ C C +GF+ + GR C D++EC A + C+N GSY C C
Sbjct: 869 CGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSC 928
Query: 224 DEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
GF ++ K C DV+EC RC Q C N GSY C+C R G +L++D TC DI C
Sbjct: 929 ASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYC--RQGYQLAEDGHTCTDIDEC 986
Score = 112 bits (280), Expect = 1e-24
Identities = 65/181 (35%), Positives = 94/181 (51%), Gaps = 19/181 (10%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQICHN 173
++C +P R C++ +G++ C C +G+ G+ C+ DVNEC + C Q C N
Sbjct: 903 NECWASP-GRLCQHTCENTLGSYRCSCASGFLLAADGKRCE-DVNECEAQR--CSQECAN 958
Query: 174 KPGSFHCSCHSGFELSSDGRTCQDIDECADSEA-CGEARCKNLPGSYSCLC-DEGFAYSS 231
GS+ C C G++L+ DG TC DIDECA RC N+PGSY C C ++G+ ++
Sbjct: 959 IYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTA 1018
Query: 232 QEKACRDVDECLQG--RCE--QVCVNSPGSYTC---HCDGR--GGLKLSQDMDTCEDILP 282
++C+DVDEC G C + C N GS+ C C K + TC D L
Sbjct: 1019 NGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLE 1078
Query: 283 C 283
C
Sbjct: 1079 C 1079
Score = 82.4 bits (202), Expect = 1e-15
Identities = 52/141 (36%), Positives = 69/141 (48%), Gaps = 14/141 (9%)
Query: 158 NECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDEC-ADSEACGEA-RCKNL 215
N C ++NG C Q+C GS CSC G+ + +DG +C+DI+EC D C C N
Sbjct: 681 NTC-KDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNT 739
Query: 216 PGSYSC----LCDEGFAYSSQEKACRDVDECLQG--RCEQ--VCVNSPGSYTCHCDGRGG 267
GS+ C C+ G+A E C DVDEC G C+ +C N+ GS+ C R
Sbjct: 740 LGSFHCYKALTCEPGYALKDGE--CEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCM 797
Query: 268 LKLSQDMD-TCEDILPCVPFS 287
QD + C DI C S
Sbjct: 798 DGFLQDPEGNCVDINECTSLS 818
Score = 67.4 bits (163), Expect = 4e-11
Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 47/170 (27%)
Query: 156 DVNECSQENGG-CLQICHNKPGSFHCSCHSGFELSSDGRTCQ------------------ 196
D +EC G C +C N GS+HC+C GF L DGRTC+
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663
Query: 197 ---------------DIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDE 241
+ C D+ C + C + GS C C G+A + +C D++E
Sbjct: 664 EFSQVASNTIPLPLPQPNTCKDNGPCKQV-CSTVGGSAICSCFPGYAIMADGVSCEDINE 722
Query: 242 CLQG--RCE--QVCVNSPGSYTCH----CDGRGGLKLSQDMDTCEDILPC 283
C+ C + CVN+ GS+ C+ C+ LK + CED+ C
Sbjct: 723 CVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE----CEDVDEC 768
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 120 bits (301), Expect = 4e-27
Identities = 71/180 (39%), Positives = 96/180 (53%), Gaps = 19/180 (10%)
Query: 118 DQCTP--NPCDRKGTQACQDLMGNFFC-----LCKAGW----GGRLCDKDVNECSQENGG 166
++CT PC R G +C + +G++ C +C G+ G C DVNEC
Sbjct: 859 NECTSLSEPC-RPGF-SCINTVGSYTCQRNPLICARGYHASDDGTKC-VDVNECETGVHR 915
Query: 167 CL--QICHNKPGSFHCSCHSGFELSSDGRTCQDIDEC-ADSEACGEARCKNLPGSYSCLC 223
C Q+CHN PGS+ C C +GF+ + GR C D++EC A + C+N GSY C C
Sbjct: 916 CGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSC 975
Query: 224 DEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
GF ++ K C DV+EC RC Q C N GSY C+C R G +L++D TC DI C
Sbjct: 976 ASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYC--RQGYQLAEDGHTCTDIDEC 1033
Score = 112 bits (280), Expect = 1e-24
Identities = 65/181 (35%), Positives = 94/181 (51%), Gaps = 19/181 (10%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQICHN 173
++C +P R C++ +G++ C C +G+ G+ C+ DVNEC + C Q C N
Sbjct: 950 NECWASP-GRLCQHTCENTLGSYRCSCASGFLLAADGKRCE-DVNECEAQR--CSQECAN 1005
Query: 174 KPGSFHCSCHSGFELSSDGRTCQDIDECADSEA-CGEARCKNLPGSYSCLC-DEGFAYSS 231
GS+ C C G++L+ DG TC DIDECA RC N+PGSY C C ++G+ ++
Sbjct: 1006 IYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTA 1065
Query: 232 QEKACRDVDECLQG--RCE--QVCVNSPGSYTC---HCDGR--GGLKLSQDMDTCEDILP 282
++C+DVDEC G C + C N GS+ C C K + TC D L
Sbjct: 1066 NGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLE 1125
Query: 283 C 283
C
Sbjct: 1126 C 1126
Score = 79.3 bits (194), Expect = 1e-14
Identities = 65/193 (33%), Positives = 88/193 (45%), Gaps = 31/193 (16%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFC-----LCKAGW---GGRLCDKDVNECSQENGGCL- 168
D+C D Q C + +G+F+C LC G+ R C D+NEC + C
Sbjct: 721 DECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKC-VDINECVTDLHTCSR 779
Query: 169 -QICHNKPGSFHC----SCHSGFELSSDGRTCQDIDECA-DSEACGEA-RCKNLPGSYSC 221
+ C N GSFHC +C G+ L DG C+D+DECA + C C+N GS+ C
Sbjct: 780 GEHCVNTLGSFHCYKALTCEPGYAL-KDGE-CEDVDECAMGTHTCQPGFLCQNTKGSFYC 837
Query: 222 ----LCDEGFAYSSQEKACRDVDEC--LQGRCEQ--VCVNSPGSYTCHCDG---RGGLKL 270
C +GF E C D++EC L C C+N+ GSYTC + G
Sbjct: 838 QARQRCMDGF-LQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHA 896
Query: 271 SQDMDTCEDILPC 283
S D C D+ C
Sbjct: 897 SDDGTKCVDVNEC 909
Score = 76.3 bits (186), Expect = 9e-14
Identities = 65/191 (34%), Positives = 82/191 (42%), Gaps = 30/191 (15%)
Query: 122 PNPCDRKGT--QACQDLMGNFFCLCKAGWG----GRLCDKDVNECSQENGGCL--QICHN 173
PN C G Q C + G+ C C G+ G C+ D +EC C Q C N
Sbjct: 680 PNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCE-DQDECLMGAHDCSRRQFCVN 738
Query: 174 KPGSFHCSCHSGFELSSDG------RTCQDIDECA-DSEACGEAR-CKNLPGSYSCL--- 222
GSF+C H+ L +DG R C DI+EC D C C N GS+ C
Sbjct: 739 TLGSFYCVNHT--VLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKAL 796
Query: 223 -CDEGFAYSSQEKACRDVDECLQG--RCEQ--VCVNSPGSYTCHCDGRGGLKLSQDMD-T 276
C+ G+A E C DVDEC G C+ +C N+ GS+ C R QD +
Sbjct: 797 TCEPGYALKDGE--CEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGN 854
Query: 277 CEDILPCVPFS 287
C DI C S
Sbjct: 855 CVDINECTSLS 865
Score = 70.1 bits (170), Expect = 6e-12
Identities = 44/143 (30%), Positives = 59/143 (41%), Gaps = 39/143 (27%)
Query: 156 DVNECSQENGG-CLQICHNKPGSFHCSCHSGFELSSDGRTCQ------------------ 196
D +EC G C +C N GS+HC+C GF L DGRTC+
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663
Query: 197 ---------------DIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDE 241
+ C D+ C + C + GS C C G+A + +C D DE
Sbjct: 664 EFSQVASNTIPLPLPQPNTCKDNGPCKQV-CSTVGGSAICSCFPGYAIMADGVSCEDQDE 722
Query: 242 CLQGRCE----QVCVNSPGSYTC 260
CL G + Q CVN+ GS+ C
Sbjct: 723 CLMGAHDCSRRQFCVNTLGSFYC 745
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 120 bits (300), Expect = 5e-27
Identities = 63/168 (37%), Positives = 89/168 (52%), Gaps = 11/168 (6%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCD---KDVNECSQENGGCLQ-ICHN 173
D+C NPC C + G++ C C+AG+ L +D++EC Q C C N
Sbjct: 492 DECEKNPC---AGGECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCIN 548
Query: 174 KPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQE 233
GSFHC C++GF ++ DG+ C+D+DEC+ C C N GS+ C+C GF +S
Sbjct: 549 TDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDG 608
Query: 234 KACRDVDEC-LQGRC-EQVCVNSPGSYTCHCDGRGGLKLSQDMDTCED 279
+ C+D++EC G C CVN+ GSY C C GL + D C D
Sbjct: 609 RYCKDINECETPGICMNGRCVNTDGSYRCEC--FPGLAVGLDGRVCVD 654
Score = 116 bits (291), Expect = 6e-26
Identities = 54/129 (41%), Positives = 72/129 (55%), Gaps = 3/129 (2%)
Query: 143 LCKAGWGGRLCDKDVNECSQENGGCLQ-ICHNKPGSFHCSCHSGFELSSDGRTCQDIDEC 201
LC +G G D+NEC+ + C IC N G++ C C+SG+E+ S G+ C DI+EC
Sbjct: 710 LCSSGPGMTSAGSDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINEC 769
Query: 202 A-DSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRC-EQVCVNSPGSYT 259
+S C +C+N PGS+ C C +GF Y K C D+DEC C VC NSPGS+
Sbjct: 770 VLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFI 829
Query: 260 CHCDGRGGL 268
C C L
Sbjct: 830 CECSSESTL 838
Score = 115 bits (289), Expect = 1e-25
Identities = 62/158 (39%), Positives = 83/158 (52%), Gaps = 10/158 (6%)
Query: 133 CQDLMGNFFCLCKAGW-GGRLCDKDVNECSQENGGCLQI--CHNKPGSFHCSCHSGFELS 189
C + G+F C C GW G + D++ECS C Q C N GS+ C C G+ +
Sbjct: 1339 CTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGY--T 1396
Query: 190 SDGRTCQDIDECADS-EACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDEC-LQGRC 247
DG TC D+DEC+++ CG +C N PG Y C CD GF S+ KAC D+DEC L C
Sbjct: 1397 GDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNIC 1456
Query: 248 E-QVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCV 284
C N PG + C C+ G +L + C D+ C+
Sbjct: 1457 VFGTCHNLPGLFRCECE--IGYELDRSGGNCTDVNECL 1492
Score = 115 bits (287), Expect = 2e-25
Identities = 73/199 (36%), Positives = 102/199 (51%), Gaps = 20/199 (10%)
Query: 95 CINKYGSPYTK-NSGFATCVQNLPDQCTP-NPCDRK--GTQACQDLMGNFFCLCKAGW-- 148
CI+ GS Y ++GF T + C N C+R G C++ +G+F C C G+
Sbjct: 1865 CIDTVGSFYCLCHTGFKT--NDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFIL 1922
Query: 149 -GGRLCDKDVNECSQENGGCLQI--CHNKPGSFHCSCHSGFELSSDGRTCQDIDEC-ADS 204
C DV+EC+ NG + C N GSF C C+ G+E++ DGRTC DI+EC +
Sbjct: 1923 SHNNDCI-DVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEP 1981
Query: 205 EACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGR---CEQVCVNSPGSYTCH 261
C C+NL GSY C+C G YS Q + C D+DEC++ C N+ GS+ C
Sbjct: 1982 RKCAPGTCQNLDGSYRCICPPG--YSLQNEKCEDIDECVEEPEICALGTCSNTEGSFKCL 2039
Query: 262 CDGRGGLKLSQDMDTCEDI 280
C G LS C+D+
Sbjct: 2040 CP--EGFSLSSSGRRCQDL 2056
Score = 114 bits (286), Expect = 2e-25
Identities = 59/159 (37%), Positives = 85/159 (53%), Gaps = 13/159 (8%)
Query: 133 CQDLMGNFFCLCKAGWG----GRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFEL 188
C + G++ C+CK G+ G C D+NEC+Q C IC N GS+ CSC G+ L
Sbjct: 2418 CVNDRGSYHCICKTGYTPDITGTSC-VDLNECNQAPKPCNFICKNTEGSYQCSCPKGYIL 2476
Query: 189 SSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQG--- 245
DGR+C+D+DECA + + C N G ++C C GF + +C D +EC
Sbjct: 2477 QEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGF--TQHHTSCIDNNECTSDINL 2534
Query: 246 -RCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
+ +C N+PGS+TC C + G L Q +CED+ C
Sbjct: 2535 CGSKGICQNTPGSFTCEC--QRGFSLDQTGSSCEDVDEC 2571
Score = 113 bits (283), Expect = 5e-25
Identities = 57/138 (41%), Positives = 75/138 (54%), Gaps = 12/138 (8%)
Query: 133 CQDLMGNFFCLCKAGW-GGRLCDKDVNECSQE-----NGGCLQICHNKPGSFHCSCHSGF 186
C++ MG++ CLCK G+ G D++ECS+ NG CL N PG + C C GF
Sbjct: 1380 CKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCL----NAPGGYRCECDMGF 1435
Query: 187 ELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGR 246
S+DG+ C+DIDEC+ C C NLPG + C C+ G+ C DV+ECL
Sbjct: 1436 VPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPT 1495
Query: 247 --CEQVCVNSPGSYTCHC 262
CVN+PGSY C C
Sbjct: 1496 TCISGNCVNTPGSYICDC 1513
Score = 112 bits (280), Expect = 1e-24
Identities = 73/183 (39%), Positives = 91/183 (49%), Gaps = 19/183 (10%)
Query: 111 TCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDK---DVNECS--QENG 165
TCV PN C GT C++ G+F C C G+ G+ D+NEC N
Sbjct: 1277 TCVDVNECDLNPNIC-LSGT--CENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNC 1333
Query: 166 GCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECAD-SEACGE-ARCKNLPGSYSCLC 223
G +C N GSF CSC G+ DG C D+DEC++ + C + A CKN GSY CLC
Sbjct: 1334 GKHAVCTNTAGSFKCSCSPGW--IGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLC 1391
Query: 224 DEGFAYSSQEKACRDVDECLQGR--CEQ-VCVNSPGSYTCHCDGRGGLKLSQDMDTCEDI 280
EG Y+ C D+DEC + C C+N+PG Y C CD G S D CEDI
Sbjct: 1392 KEG--YTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECD--MGFVPSADGKACEDI 1447
Query: 281 LPC 283
C
Sbjct: 1448 DEC 1450
Score = 109 bits (273), Expect = 7e-24
Identities = 70/218 (32%), Positives = 98/218 (44%), Gaps = 19/218 (8%)
Query: 58 QGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTK-NSGFA----TC 112
+G + C + +E+ R + D + C+N G K GF +C
Sbjct: 2463 EGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTSC 2522
Query: 113 VQNLPDQCTP--NPCDRKGTQACQDLMGNFFCLCKAGWG----GRLCDKDVNECSQENGG 166
+ N ++CT N C KG CQ+ G+F C C+ G+ G C+ DV+EC + N
Sbjct: 2523 IDN--NECTSDINLCGSKGI--CQNTPGSFTCECQRGFSLDQTGSSCE-DVDEC-EGNHR 2576
Query: 167 CLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEG 226
C C N G + CSC G+ C D +EC + CG A C N GSY C+C G
Sbjct: 2577 CQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHNTLGSYKCMCPAG 2636
Query: 227 FAYSSQEKACRDVDEC--LQGRCEQVCVNSPGSYTCHC 262
F Y C+D++EC Q C C N+ G Y C C
Sbjct: 2637 FQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGC 2674
Score = 105 bits (262), Expect = 1e-22
Identities = 64/200 (32%), Positives = 86/200 (43%), Gaps = 54/200 (27%)
Query: 133 CQDLMGNFFCLCKAGWGG---RLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELS 189
C +L+G + C C G+ RL D++ECS NGGC C N GS+ CSC GF L
Sbjct: 1171 CVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALM 1230
Query: 190 SDGRTCQDIDECADS-EACGEARCKNLPGSYSCL-------------------------- 222
D R+C DIDEC D+ C +C N+PG Y CL
Sbjct: 1231 PDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNI 1290
Query: 223 ----------------CDEGFAYSSQEKACRDVDECLQG--RC--EQVCVNSPGSYTCHC 262
CD G++ + C D++EC G C VC N+ GS+ C C
Sbjct: 1291 CLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSC 1350
Query: 263 DG---RGGLKLSQDMDTCED 279
G+K + D+D C +
Sbjct: 1351 SPGWIGDGIKCT-DLDECSN 1369
Score = 99.8 bits (247), Expect = 8e-21
Identities = 60/175 (34%), Positives = 81/175 (46%), Gaps = 14/175 (8%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDK-----DVNECSQENGGCLQ-IC 171
D+C +P +G C + G++ C C G +L D+NEC C C
Sbjct: 1115 DECQRDPLLCRGG-VCHNTEGSYRCECPPGH--QLSPNISACIDINECELSAHLCPNGRC 1171
Query: 172 HNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSS 231
N G + C+C+ G+ + D C DIDEC+ E C N GSY C C GFA
Sbjct: 1172 VNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMP 1231
Query: 232 QEKACRDVDECLQGR--CE-QVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
+++C D+DEC C+ C N PG Y C C G S+DM TC D+ C
Sbjct: 1232 DQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLC--YDGFMASEDMKTCVDVNEC 1284
Score = 92.8 bits (229), Expect = 9e-19
Identities = 56/159 (35%), Positives = 72/159 (45%), Gaps = 17/159 (10%)
Query: 91 RYLDCINKYGS-------PYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCL 143
++ DC N GS YT GF TC D+C+ N + G C + G + C
Sbjct: 1376 QHADCKNTMGSYRCLCKEGYT-GDGF-TCTDL--DECSEN-LNLCGNGQCLNAPGGYRCE 1430
Query: 144 CKAGW----GGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDID 199
C G+ G+ C+ D++ECS N CHN PG F C C G+EL G C D++
Sbjct: 1431 CDMGFVPSADGKACE-DIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVN 1489
Query: 200 ECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRD 238
EC D C C N PGSY C C F + C D
Sbjct: 1490 ECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVD 1528
Score = 90.5 bits (223), Expect = 5e-18
Identities = 57/176 (32%), Positives = 87/176 (49%), Gaps = 19/176 (10%)
Query: 118 DQCT--PNPCDRKGTQACQDLMGNFFCLCKAGW---GGRLCDKDVNECSQENGGCLQI-- 170
D+C P C+ C +++G+F C C G+ L +D++EC +NG Q
Sbjct: 1768 DECREIPGVCENG---VCINMVGSFRCECPVGFFYNDKLLVCEDIDEC--QNGPVCQRNA 1822
Query: 171 -CHNKPGSFHCSCHSGFELSSDGRTCQDIDECAD-SEACGEARCKNLPGSYSCLCDEGFA 228
C N GS+ C C G+ +S G+ C D +EC + C +C + GS+ CLC GF
Sbjct: 1823 ECINTAGSYRCDCKPGYRFTSTGQ-CNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFK 1881
Query: 229 YSSQEKACRDVDECLQGRC-EQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
+ + C D++EC + C C N+ GS+ C C+ G LS + D C D+ C
Sbjct: 1882 TNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCN--HGFILSHNND-CIDVDEC 1934
Score = 89.7 bits (221), Expect = 8e-18
Identities = 58/173 (33%), Positives = 78/173 (45%), Gaps = 13/173 (7%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGW--GGRLCDKDVNECSQENGGCLQICHNKP 175
D+C + G C + G++ C C G+ G C D +ECS N C N
Sbjct: 2129 DECKEPDVCKHGQ--CINTDGSYRCECPFGYILAGNEC-VDTDECSVGNPCGNGTCKNVI 2185
Query: 176 GSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKA 235
G F C+C GFE TC+DI+ECA + RC N GSY C C G+ +
Sbjct: 2186 GGFECTCEEGFE-PGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRM 2244
Query: 236 CRDVDECLQGR--C---EQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPC 283
C+D DEC +G+ C + C N G+Y C C G + D + C D C
Sbjct: 2245 CKDEDECEEGKHDCTEKQMECKNLIGTYMCICG--PGYQRRPDGEGCVDENEC 2295
Score = 89.4 bits (220), Expect = 1e-17
Identities = 49/124 (39%), Positives = 67/124 (54%), Gaps = 11/124 (8%)
Query: 163 ENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCL 222
+NG C+ PGS C C+ GF+L G C D+DEC + C C N GSY+C
Sbjct: 461 QNGRCIPT----PGSCRCECNKGFQLDLRGE-CIDVDEC-EKNPCAGGECINNQGSYTCQ 514
Query: 223 CDEGFAYSSQEKACRDVDECLQ-GR-CEQ-VCVNSPGSYTCHCDGRGGLKLSQDMDTCED 279
C G+ + CRD+DECLQ GR C C+N+ GS+ C C+ G +++D CED
Sbjct: 515 CRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCN--AGFHVTRDGKNCED 572
Query: 280 ILPC 283
+ C
Sbjct: 573 MDEC 576
Score = 84.7 bits (208), Expect = 3e-16
Identities = 60/181 (33%), Positives = 80/181 (44%), Gaps = 29/181 (16%)
Query: 133 CQDLMGNFFCLCKAGW----GGRLCDKDVNECSQENGGCLQ-ICHNKPGSFHCSCHSGFE 187
C++L G + C+C +G+ G+ C D+NEC + C C N PGSF C+C GF
Sbjct: 739 CENLRGTYKCICNSGYEVDSTGKNC-VDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFI 797
Query: 188 LSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDV------DE 241
D +TC+DIDEC +S C CKN PGS+ C C + C +
Sbjct: 798 YKPDLKTCEDIDEC-ESSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQT 856
Query: 242 CLQGRCE---------QVCVNSPGS------YTCHCDGRGGLKLSQDMDT-CEDILPCVP 285
+ GRCE C +S G+ C D G S+ T CEDI C
Sbjct: 857 VIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQCEDIDECEV 916
Query: 286 F 286
F
Sbjct: 917 F 917
Score = 84.7 bits (208), Expect = 3e-16
Identities = 67/235 (28%), Positives = 92/235 (39%), Gaps = 68/235 (28%)
Query: 95 CINKYGS-----PYTKNSGFATCVQNLPDQCTP-NPCDRKGTQACQDLMGNFFCLCKAGW 148
CIN GS P+ CV D+C+ NPC G C++++G F C C+ G+
Sbjct: 2142 CINTDGSYRCECPFGYILAGNECVDT--DECSVGNPC---GNGTCKNVIGGFECTCEEGF 2196
Query: 149 --GGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSE- 205
G + +D+NEC+Q C C N GS+ C C G+ L D R C+D DEC + +
Sbjct: 2197 EPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKH 2256
Query: 206 --------------------------------------------ACGEARCKNLPGSYSC 221
C RC N GSY+C
Sbjct: 2257 DCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTC 2316
Query: 222 LCDEGFAYSSQEKACRD------VDECLQGRCEQVCVNSPGSYT---CHCDGRGG 267
C++GF S + C D E LQ C Q+ ++ T C CDG G
Sbjct: 2317 ECNDGFTASPNQDECLDNREGYCFTEVLQNMC-QIGSSNRNPVTKSECCCDGGRG 2370
Score = 79.3 bits (194), Expect = 1e-14
Identities = 61/187 (32%), Positives = 84/187 (44%), Gaps = 33/187 (17%)
Query: 111 TCVQNLPDQ-CTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQ 169
TC D+ CT R AC C A WG C+ EC N +
Sbjct: 957 TCFLRYEDEECTLPIAGRHRMDAC-------CCSVGAAWGTEECE----ECPMRNTPEYE 1005
Query: 170 -ICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEA-CGEARCKNLPGSYSCLCDEGF 227
+C PG + E+++ +DI+EC + C +C+N GS+ C CD GF
Sbjct: 1006 ELCPRGPG------FATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGF 1059
Query: 228 AYSSQEKACRDVDEC-----LQGRCEQVCVNSPGSYTCHCD-----GRGGLKLSQDMDTC 277
A S+E+ C D+DEC L GR + CVN+PG + C CD G +K D+D C
Sbjct: 1060 ALDSEERNCTDIDECRISPDLCGRGQ--CVNTPGDFECKCDEGYESGFMMMKNCMDIDEC 1117
Query: 278 E-DILPC 283
+ D L C
Sbjct: 1118 QRDPLLC 1124
Score = 71.2 bits (173), Expect = 3e-12
Identities = 42/141 (29%), Positives = 63/141 (44%), Gaps = 13/141 (9%)
Query: 143 LCKAGWGGR-----LCDKDVNECSQENGGCLQ-ICHNKPGSFHCSCHSGFELSSDGRTCQ 196
LC G G R + +D++EC + G C C N GSF C C +G+ L+ D R C
Sbjct: 1588 LCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCD 1647
Query: 197 DIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPG 256
D++EC CG C N G+Y+C+C + + C D+ L C +
Sbjct: 1648 DVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSL-------CYRNYY 1700
Query: 257 SYTCHCDGRGGLKLSQDMDTC 277
+ CDG +++ M C
Sbjct: 1701 ADNQTCDGELLFNMTKKMCCC 1721
Score = 70.5 bits (171), Expect = 5e-12
Identities = 40/117 (34%), Positives = 55/117 (47%), Gaps = 14/117 (11%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQI------- 170
D+C N + G CQ+++G + C C G+ L N+C EN CL
Sbjct: 2569 DECEGNHRCQHG---CQNIIGGYRCSCPQGY---LQHYQWNQCVDENE-CLSAHICGGAS 2621
Query: 171 CHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGF 227
CHN GS+ C C +GF+ CQDI+EC ++A C N G Y C C G+
Sbjct: 2622 CHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGY 2678
Score = 67.0 bits (162), Expect = 5e-11
Identities = 41/117 (35%), Positives = 49/117 (41%), Gaps = 8/117 (6%)
Query: 155 KDVNECSQENGGCLQ-ICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEA-CGEARC 212
+DV+EC G C C N GSF C C +G +L+ + C+DIDEC+ C C
Sbjct: 245 QDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGEC 304
Query: 213 KNLPGSYSCLCDEGFAYSSQEKACRDV------DECLQGRCEQVCVNSPGSYTCHCD 263
N SY C C GF S C DV GRC S C CD
Sbjct: 305 TNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCCCD 361
Score = 66.2 bits (160), Expect = 9e-11
Identities = 65/241 (26%), Positives = 93/241 (38%), Gaps = 61/241 (25%)
Query: 95 CINKYGS-------PYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAG 147
CIN +GS Y N C ++ + TP C G C + +GN+ C+C
Sbjct: 1622 CINTFGSFQCRCPTGYYLNEDTRVC-DDVNECETPGIC---GPGTCYNTVGNYTCICPPD 1677
Query: 148 W----GGRLC-DKDVNECSQENGGCLQICH----------------------NKP----- 175
+ GG C D + C + Q C NKP
Sbjct: 1678 YMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCP 1737
Query: 176 ----GSFHCSCHS---GFELSSDGRTCQDIDECADSEA-CGEARCKNLPGSYSCLCDEGF 227
F C S GF + DIDEC + C C N+ GS+ C C GF
Sbjct: 1738 IPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGF 1797
Query: 228 AYSSQEKACRDVDECLQGR-CEQ--VCVNSPGSYTCHCDGRGGLKLS-----QDMDTCED 279
Y+ + C D+DEC G C++ C+N+ GSY C C + G + + D + C++
Sbjct: 1798 FYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDC--KPGYRFTSTGQCNDRNECQE 1855
Query: 280 I 280
I
Sbjct: 1856 I 1856
Score = 65.1 bits (157), Expect = 2e-10
Identities = 58/203 (28%), Positives = 77/203 (37%), Gaps = 44/203 (21%)
Query: 118 DQCTPNPCDRKGTQACQDLMGNFFCLCKAGWG----GRLCD------------------- 154
D+C P + C + G+F CLC G+ GR C
Sbjct: 2015 DECVEEP-EICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSP 2073
Query: 155 KDVNECSQEN---------GGCLQICHNKPGSFH---CSCHSGFELSSDGRTCQDIDECA 202
K N QE G ++C +P C SG + D + D+DEC
Sbjct: 2074 KSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDD-SAVDMDECK 2132
Query: 203 DSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGR-C-EQVCVNSPGSYTC 260
+ + C +C N GSY C C G+ + E C D DEC G C C N G + C
Sbjct: 2133 EPDVCKHGQCINTDGSYRCECPFGYILAGNE--CVDTDECSVGNPCGNGTCKNVIGGFEC 2190
Query: 261 HCDGRGGLKLSQDMDTCEDILPC 283
C+ G + M TCEDI C
Sbjct: 2191 TCE--EGFE-PGPMMTCEDINEC 2210
Score = 65.1 bits (157), Expect = 2e-10
Identities = 64/258 (24%), Positives = 88/258 (34%), Gaps = 48/258 (18%)
Query: 63 RECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTP 122
R C +E E + E E Y+ CI G Y + CV Q P
Sbjct: 2243 RMCKDEDECEEGKHDCTEKQMECKNLIGTYM-CI--CGPGYQRRPDGEGCVDENECQTKP 2299
Query: 123 NPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNEC-SQENGGCL-----QICH---- 172
C+ C + G++ C C G+ + +EC G C +C
Sbjct: 2300 GICENG---RCLNTRGSYTCECNDGF---TASPNQDECLDNREGYCFTEVLQNMCQIGSS 2353
Query: 173 --NKPGSFHCSCHSGFELSSDGRTCQ----------------------DIDEC-ADSEAC 207
N C C G C DIDEC + C
Sbjct: 2354 NRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVC 2413
Query: 208 GEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQG--RCEQVCVNSPGSYTCHCDGR 265
C N GSY C+C G+ +C D++EC Q C +C N+ GSY C C
Sbjct: 2414 RNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCP-- 2471
Query: 266 GGLKLSQDMDTCEDILPC 283
G L +D +C+D+ C
Sbjct: 2472 KGYILQEDGRSCKDLDEC 2489
Score = 63.9 bits (154), Expect = 5e-10
Identities = 53/184 (28%), Positives = 74/184 (40%), Gaps = 47/184 (25%)
Query: 143 LCKAGWG---GRLCDKDVNECSQENGGCLQ-ICHNKPGSFHCSCHSGFELSSDGRTCQDI 198
+C G+ G C+ D++EC G C +C N GSF C C SG L + GR C DI
Sbjct: 895 ICGKGYSRIKGTQCE-DIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDI 953
Query: 199 -----------DECA--------------------DSEACGEARCKNLPGSYSCLCDEGF 227
+EC +E C E +N P Y LC G
Sbjct: 954 RLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTP-EYEELCPRGP 1012
Query: 228 AYSSQE-----KACRDVDEC--LQGRCEQ-VCVNSPGSYTCHCDGRGGLKLSQDMDTCED 279
++++E +D++EC + C C N+ GS+ C CD G L + C D
Sbjct: 1013 GFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCD--SGFALDSEERNCTD 1070
Query: 280 ILPC 283
I C
Sbjct: 1071 IDEC 1074
Score = 63.5 bits (153), Expect = 6e-10
Identities = 63/255 (24%), Positives = 83/255 (32%), Gaps = 73/255 (28%)
Query: 95 CINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNF------FCLCKAGW 148
C + G + TC Q P+ C + Q C N CLC+ G+
Sbjct: 85 CRHSCGDGFCSRPNMCTCPSG---QIAPS-CGSRSIQHCNIRCMNGGSCSDDHCLCQKGY 140
Query: 149 GGRLCDKDVNECSQENGG-CL-------------------------------QICHNKPG 176
G C + V E NGG C+ Q+C +
Sbjct: 141 IGTHCGQPVCESGCLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLS 200
Query: 177 SFHCS-------------------------CHSGFELSSDGRTCQDIDEC-ADSEACGEA 210
C+ C GF + CQD+DEC A C
Sbjct: 201 GIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGG 260
Query: 211 RCKNLPGSYSCLCDEGFAYSSQEKACRDVDEC--LQGRCE-QVCVNSPGSYTCHCDGRGG 267
C N GS+ C C G + + C D+DEC + G CE C N+ SY C C G
Sbjct: 261 NCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCP--PG 318
Query: 268 LKLSQDMDTCEDILP 282
S D C D+ P
Sbjct: 319 FYTSPDGTRCIDVRP 333
Score = 62.8 bits (151), Expect = 1e-09
Identities = 59/215 (27%), Positives = 90/215 (41%), Gaps = 46/215 (21%)
Query: 101 SPYTKNSGFATCVQNLPDQCTPNP--CDRKGTQACQDLMGNFFCLCKAGW----GGRLCD 154
S Y +S CV ++C N CD C++ G+F C C G+ + C+
Sbjct: 752 SGYEVDSTGKNCVDI--NECVLNSLLCDNG---QCRNTPGSFVCTCPKGFIYKPDLKTCE 806
Query: 155 KDVNECSQENGGCLQ-ICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCK 213
D++EC E+ C+ +C N PGSF C C S L C + + + + RC+
Sbjct: 807 -DIDEC--ESSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCE 863
Query: 214 -NLPGS---YSCLCDEGFAYSS------------------QEKACRDVDEC--LQGRCEQ 249
N+ G+ C G A+ S + C D+DEC G C+
Sbjct: 864 ININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQCEDIDECEVFPGVCKN 923
Query: 250 -VCVNSPGSYTCHC------DGRGGLKLSQDMDTC 277
+CVN+ GS+ C C D G + L ++TC
Sbjct: 924 GLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETC 958
Score = 58.2 bits (139), Expect = 3e-08
Identities = 31/79 (39%), Positives = 41/79 (51%), Gaps = 4/79 (5%)
Query: 207 CGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCE-QVCVNSPGSYTCHCDGR 265
C RC PGS C C++GF + + C DVDEC + C C+N+ GSYTC C R
Sbjct: 460 CQNGRCIPTPGSCRCECNKGFQLDLRGE-CIDVDECEKNPCAGGECINNQGSYTCQC--R 516
Query: 266 GGLKLSQDMDTCEDILPCV 284
G + + C DI C+
Sbjct: 517 AGYQSTLTRTECRDIDECL 535
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,594,497
Number of Sequences: 37866
Number of extensions: 1392492
Number of successful extensions: 7083
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 165
Number of HSP's successfully gapped in prelim test: 164
Number of HSP's that attempted gapping in prelim test: 3190
Number of HSP's gapped (non-prelim): 1647
length of query: 678
length of database: 18,247,518
effective HSP length: 109
effective length of query: 569
effective length of database: 14,120,124
effective search space: 8034350556
effective search space used: 8034350556
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.