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Search of human proteins with 45387958
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45387958 1A6/DRIM (down-regulated in metastasis) interacting
protein [Homo sapiens]
(1209 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45387958 1A6/DRIM (down-regulated in metastasis) interacting ... 2417 0.0
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 63 2e-09
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 63 2e-09
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 61 6e-09
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 61 6e-09
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 61 6e-09
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 61 7e-09
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 61 7e-09
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 56 2e-07
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 55 4e-07
gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens] 54 1e-06
gi|33946327 nucleoporin 214kDa [Homo sapiens] 52 3e-06
gi|239758013 PREDICTED: hypothetical protein [Homo sapiens] 50 1e-05
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 50 1e-05
gi|153070260 myristoylated alanine-rich protein kinase C substra... 48 6e-05
gi|47578107 delangin isoform B [Homo sapiens] 47 8e-05
gi|47578105 delangin isoform A [Homo sapiens] 47 8e-05
gi|163965366 nascent polypeptide-associated complex alpha subuni... 47 1e-04
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens] 46 2e-04
gi|148727255 microtubule associated serine/threonine kinase fami... 46 2e-04
gi|148806908 fibronectin type III domain containing 1 [Homo sapi... 46 2e-04
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 46 2e-04
gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens] 46 2e-04
gi|112821681 G protein-regulated inducer of neurite outgrowth 1 ... 45 3e-04
gi|91208420 bassoon protein [Homo sapiens] 45 4e-04
gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens] 45 5e-04
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 44 7e-04
gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Hom... 44 0.001
gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Hom... 44 0.001
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 44 0.001
>gi|45387958 1A6/DRIM (down-regulated in metastasis) interacting
protein [Homo sapiens]
Length = 1209
Score = 2417 bits (6265), Expect = 0.0
Identities = 1209/1209 (100%), Positives = 1209/1209 (100%)
Query: 1 MFLMNASPVVALQSKWEAFGPPGSCRFPRCFSEADEGVESASVSARVQMLISTLQRDGAA 60
MFLMNASPVVALQSKWEAFGPPGSCRFPRCFSEADEGVESASVSARVQMLISTLQRDGAA
Sbjct: 1 MFLMNASPVVALQSKWEAFGPPGSCRFPRCFSEADEGVESASVSARVQMLISTLQRDGAA 60
Query: 61 RGTSDERAAQRGHRAEGCHDARPAAKPTVHKEPPALAVCGLVADFDPMGEEETTDFGPLV 120
RGTSDERAAQRGHRAEGCHDARPAAKPTVHKEPPALAVCGLVADFDPMGEEETTDFGPLV
Sbjct: 61 RGTSDERAAQRGHRAEGCHDARPAAKPTVHKEPPALAVCGLVADFDPMGEEETTDFGPLV 120
Query: 121 LDSDSDDSVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGS 180
LDSDSDDSVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGS
Sbjct: 121 LDSDSDDSVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGS 180
Query: 181 APTALCPPKLVPGSGGGPGSQVGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQH 240
APTALCPPKLVPGSGGGPGSQVGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQH
Sbjct: 181 APTALCPPKLVPGSGGGPGSQVGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQH 240
Query: 241 ETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRLAKMNV 300
ETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRLAKMNV
Sbjct: 241 ETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRLAKMNV 300
Query: 301 QPRSLRSKVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRGKRVMSAAQASEAS 360
QPRSLRSKVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRGKRVMSAAQASEAS
Sbjct: 301 QPRSLRSKVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRGKRVMSAAQASEAS 360
Query: 361 DSSSDDGIEEAIQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHSTSSATKSALPETHR 420
DSSSDDGIEEAIQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHSTSSATKSALPETHR
Sbjct: 361 DSSSDDGIEEAIQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHSTSSATKSALPETHR 420
Query: 421 KTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAPPPASPASRSEFVERSSCRADTSAE 480
KTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAPPPASPASRSEFVERSSCRADTSAE
Sbjct: 421 KTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAPPPASPASRSEFVERSSCRADTSAE 480
Query: 481 LMCAEAILDISKTILPAPVEGSDGSLSASPLFYSPNVPSRSDGDSSSVDSDDSIEQEIRT 540
LMCAEAILDISKTILPAPVEGSDGSLSASPLFYSPNVPSRSDGDSSSVDSDDSIEQEIRT
Sbjct: 481 LMCAEAILDISKTILPAPVEGSDGSLSASPLFYSPNVPSRSDGDSSSVDSDDSIEQEIRT 540
Query: 541 FLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGG 600
FLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGG
Sbjct: 541 FLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGG 600
Query: 601 HVRPSTPKKMQEVVKDGSQDADHSQGRAEPGHERRDLPIQGKASEALGGEGTARGPGDTR 660
HVRPSTPKKMQEVVKDGSQDADHSQGRAEPGHERRDLPIQGKASEALGGEGTARGPGDTR
Sbjct: 601 HVRPSTPKKMQEVVKDGSQDADHSQGRAEPGHERRDLPIQGKASEALGGEGTARGPGDTR 660
Query: 661 MSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPRAACRK 720
MSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPRAACRK
Sbjct: 661 MSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPRAACRK 720
Query: 721 KVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEGPGKKPPSVFGSTAERM 780
KVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEGPGKKPPSVFGSTAERM
Sbjct: 721 KVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEGPGKKPPSVFGSTAERM 780
Query: 781 RQEGAASQDAALAFRVRRPASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELE 840
RQEGAASQDAALAFRVRRPASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELE
Sbjct: 781 RQEGAASQDAALAFRVRRPASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELE 840
Query: 841 IRKFLAEKAKESVSSSEVQAEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPH 900
IRKFLAEKAKESVSSSEVQAEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPH
Sbjct: 841 IRKFLAEKAKESVSSSEVQAEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPH 900
Query: 901 LAEGLRGTESAGAQGTAGLFSQGGKGLPAAPARGDPVPPRSTSGGVSAKGLSVSRRNVYV 960
LAEGLRGTESAGAQGTAGLFSQGGKGLPAAPARGDPVPPRSTSGGVSAKGLSVSRRNVYV
Sbjct: 901 LAEGLRGTESAGAQGTAGLFSQGGKGLPAAPARGDPVPPRSTSGGVSAKGLSVSRRNVYV 960
Query: 961 HKDQSPRGAEPAAKSAFGQLPSCATAGTEAGGARGTFHMGCGSPSFLTPSPGAERDAGAQ 1020
HKDQSPRGAEPAAKSAFGQLPSCATAGTEAGGARGTFHMGCGSPSFLTPSPGAERDAGAQ
Sbjct: 961 HKDQSPRGAEPAAKSAFGQLPSCATAGTEAGGARGTFHMGCGSPSFLTPSPGAERDAGAQ 1020
Query: 1021 ADRTPPWSDFAHQSRLPSPWVLRSEGRDAVWRGGVGSERDKGSEGPARGLPSLPLAGFSP 1080
ADRTPPWSDFAHQSRLPSPWVLRSEGRDAVWRGGVGSERDKGSEGPARGLPSLPLAGFSP
Sbjct: 1021 ADRTPPWSDFAHQSRLPSPWVLRSEGRDAVWRGGVGSERDKGSEGPARGLPSLPLAGFSP 1080
Query: 1081 LLSTQLFHFGKGVSWGGRQAGLFSPHLGLPLQGPSFSAFREAQAGPSPVFGSPHLLAKKD 1140
LLSTQLFHFGKGVSWGGRQAGLFSPHLGLPLQGPSFSAFREAQAGPSPVFGSPHLLAKKD
Sbjct: 1081 LLSTQLFHFGKGVSWGGRQAGLFSPHLGLPLQGPSFSAFREAQAGPSPVFGSPHLLAKKD 1140
Query: 1141 GGPWPTRKAQAGLSLHDRRSSGSEESILDLRYRRRVNRDDQEQDALGSDASDFSDTSTED 1200
GGPWPTRKAQAGLSLHDRRSSGSEESILDLRYRRRVNRDDQEQDALGSDASDFSDTSTED
Sbjct: 1141 GGPWPTRKAQAGLSLHDRRSSGSEESILDLRYRRRVNRDDQEQDALGSDASDFSDTSTED 1200
Query: 1201 SGGSSVVKV 1209
SGGSSVVKV
Sbjct: 1201 SGGSSVVKV 1209
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 62.8 bits (151), Expect = 2e-09
Identities = 181/843 (21%), Positives = 285/843 (33%), Gaps = 150/843 (17%)
Query: 293 PRLAKMNVQ------PRSLRSKVTTTQENEGST-----KPAT------------PCRPSE 329
PRLA N P S++ K E G T PAT P + +E
Sbjct: 103 PRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAE 162
Query: 330 AAQN---------KGGIKRSASAARRGKRVMSAAQASEASDSSSDDGIEEAIQLYQLQKT 380
+ N +G + +AA+ G ++SA QA +S+ +S E +++ +K
Sbjct: 163 PSANTTLVSETEEEGSVPAFGAAAKPG--MVSAGQADSSSEDTSSSSDETDVEVKASEKI 220
Query: 381 RKEADGDLPQRVQLREERAPDPP--AHSTSSATKSALPE------------THRKTPSKK 426
+ P + + P PP A + +S TK+ PE + +TP+ K
Sbjct: 221 LQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAK 280
Query: 427 KLVATK----TMDPGPGGLDTDHAPKLLKETKAPPPASPA-SRSEFVERSSCRADTSAEL 481
L+ K T G +P+ P PA ++++ +R +S E
Sbjct: 281 ALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEES 340
Query: 482 MCAEAILDISKTILPAP-VEGSDGSLSASPLFYSPNVPSRSDGDSSSV--------DSDD 532
E +K AP V + SP + P R G +++ DS
Sbjct: 341 DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRS 400
Query: 533 SIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGC 592
S E+ AL A + + + PQ + G PL K P+
Sbjct: 401 SSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMG----------PLGKGAGPV--- 447
Query: 593 KRKRRGGGHVRPSTPK----KMQEVVKDGSQDA-DHSQGRAEPGHERRDLPIQGKASEAL 647
G V P+TP K +E + S+++ D S G G +A
Sbjct: 448 -----PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAK 502
Query: 648 GGEGTARGPGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKL 707
A+GP + + + +D ESSE+ S S DS+E A ++K L
Sbjct: 503 PTSSPAKGPPQ-KAGPVAVQVKAEKPMDNSESSEESSDSADSEE--APAAMTAAQAKPAL 559
Query: 708 KKRCREPRAACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEGPGK 767
K AC KK + + + PV + K + P
Sbjct: 560 K---IPQTKACPKKTNTTASA----------------KVAPVRVGTQAPRKAGTATSPAG 600
Query: 768 KPPSVFGST----AERMRQEGAASQDAALAFRVRRPASASASEGNPFPRES--------Q 815
P+V G T + E + S++ V + S +G S Q
Sbjct: 601 SSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 660
Query: 816 GPAP-SPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQAEGPTALGTGGPARP 874
G AP PG + V + + E + ++ + + S ++V+ PA
Sbjct: 661 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAA 720
Query: 875 EVLCRKEPAPPPG-VCTRSQRA--RGVPHLAEGLRGTESAG--AQGTAGLFSQGGKGLPA 929
K PG V T + +A R + +R +++ A+G A + S G A
Sbjct: 721 RAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATA 780
Query: 930 APARGDPVPPRSTS-------------GGVSAKGLSVSRRNVYVHKDQSPR-GAEPAAKS 975
A A+ P +S V G + R +SPR GA P
Sbjct: 781 AQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPG 840
Query: 976 AFGQLPSCATAGTEAGGARGTFHMGCGSPSFLTPSPGAERDAGAQADRTPPWSDFAHQSR 1035
G PS A AG + GS S + S G A A P F +R
Sbjct: 841 KTG--PSAAQAGKQDDS---------GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNR 889
Query: 1036 LPS 1038
P+
Sbjct: 890 SPA 892
Score = 48.5 bits (114), Expect = 4e-05
Identities = 129/671 (19%), Positives = 237/671 (35%), Gaps = 68/671 (10%)
Query: 83 PAAKPTVHKE--PPALAVCGLVADFDPMGEEETTDFGPLVLDSDSDDSVDRDIEEAIQEY 140
PA+ P+V K A A G D EE ++ L I A+
Sbjct: 767 PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 826
Query: 141 LKA-KSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTALC------PPKLVPG 193
++ + GAA G P AAQ + GS + + G AP A+ PP +
Sbjct: 827 KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 886
Query: 194 SGGGP-GSQVGSSKDQGSASPVSVSSDDSFEQSIRAEIE-----------------QFLN 235
P G ++ Q +++P + +S +S +E E +
Sbjct: 887 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 946
Query: 236 EKRQHETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRL 295
H S+ + E+S S K + P T+V + + A + +
Sbjct: 947 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQK 1006
Query: 296 AKMNVQPRSLRSKVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRGKRVMSAAQ 355
A QP R++ ++ ++ T PAT + S + Q KG K ++ A +
Sbjct: 1007 AS-EAQPPVARTQPSSGVDSAVGTLPATSPQ-STSVQAKGTNKLRKPKLPEVQQATKAPE 1064
Query: 356 ASEASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHSTSSATKSAL 415
+S+ S+ SSD + E DG+ PQ + P+ + + ++A
Sbjct: 1065 SSDDSEDSSD------------SSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAA 1112
Query: 416 PETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAPPPASP-ASRSEFVERSSCR 474
+ + + + + M PG ++ + K +P +S A++ + + +
Sbjct: 1113 ESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAK 1172
Query: 475 ADTSAELMC-----AEAILDISKTILPAPVEGSDGSLSASPLFYSPNVPSRSDGDSSSVD 529
+A ++ EA + P +G+ G+ AS L N+ G ++
Sbjct: 1173 PQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGA-GNPQASTLALQSNITQCLLGQPWPLN 1231
Query: 530 SDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPL 589
++ L Q + L+ +TP SK
Sbjct: 1232 EAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSK----- 1286
Query: 590 LGCKRKRRGGGHVRPS--TPKKMQEVVKDGSQDADHSQGRAEPGHERRDLPIQG----KA 643
K+K+ G G + +P+K K G D + G + + L QG
Sbjct: 1287 ---KKKKLGAGEGGEASVSPEKTSTTSK-GKAKRDKASGDVKEKKGKGSLGSQGAKDEPE 1342
Query: 644 SEALGGEGTARGPGDTR-MSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLR 702
E G GT G + S+ + K + R+ D+++ + K + S +D ++ +
Sbjct: 1343 EELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESP----SQ 1398
Query: 703 SKRKLKKRCRE 713
K+K KK+ E
Sbjct: 1399 KKKKKKKKTAE 1409
Score = 43.1 bits (100), Expect = 0.002
Identities = 189/961 (19%), Positives = 340/961 (35%), Gaps = 164/961 (17%)
Query: 122 DSDSDD----SVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGA--AQPSRAAGGGSRCKP- 174
DS S+D S + D+E E + A+ P G GA A P +A S+ K
Sbjct: 197 DSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAG 256
Query: 175 ----------EPAHGSAPTALCPPKLVPGSGGGPGSQVGSSKDQGSASPVSVSSDDSFEQ 224
E + S L+ G SQVG++ SP ++ +
Sbjct: 257 KPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK 316
Query: 225 SIRAEIEQFLNEKRQHETQKCD---GSVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLL 281
+ A + + KR+ ++Q S E+ P + S K+ P K R+G
Sbjct: 317 TGPA-VAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKG-- 373
Query: 282 GVQKEFAFRKPPRLAKMNVQPRSLRSKVTTTQENE-GSTKPATPCRPSEAAQNKGGIKRS 340
A PPR P + + +V +E+ S++ + R + AA N +K
Sbjct: 374 ------AAPAPPR----KTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 423
Query: 341 ASAAR-------------RGKRVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRKEADGD 387
+ + +G + + A+ S+ EE + +++ +DG+
Sbjct: 424 GKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSS-EESSDSSDGE 482
Query: 388 LPQRVQLREERAPDP--PAHSTSSATKSALPETHRKTPSKKKLVATKTMDPGPGG----- 440
+P V +E++ A TSS K + P ++ A K MD
Sbjct: 483 VPTAVAPAQEKSLGNILQAKPTSSPAKGP---PQKAGPVAVQVKAEKPMDNSESSEESSD 539
Query: 441 -LDTDHAPKLLKETKAPPPASPASRSEFVERSSCRADTSAELMCAEAILDISKTILPAPV 499
D++ AP + +A P + + +C T+ A + + AP
Sbjct: 540 SADSEEAPAAMTAAQAKPAL------KIPQTKACPKKTNTTASAKVAPVRVGTQ---APR 590
Query: 500 EGSDGSLSASPLFYSPNVPS---RSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGE 556
+ + SP SP V R DSSS + DS E+ +T LA+ + +G
Sbjct: 591 KAGTAT---SPAGSSPAVAGGTQRPAEDSSSSEESDSEEE--KTGLAVTVGQAKSVGKGL 645
Query: 557 SCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGGHVRPSTPKKMQEVVKD 616
+AA P+ K L + P+L K G + QE +
Sbjct: 646 QV-KAASVPV------------KGSLGQGTAPVLPGKT-----GPTVTQVKAEKQEDSES 687
Query: 617 GSQDADHSQGRAEPGHERRDLP-IQGKASEALG----GEGTARGPGDTRMSQGQGKTDEA 671
+++D + A P + + Q KA+ A +GT PG + Q K
Sbjct: 688 SEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSP 747
Query: 672 RRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQTHF 731
++ + S+ L ++ + + + + E + ++ +
Sbjct: 748 SKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE----SDSEEE 803
Query: 732 LEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEG-----PGKKPPSVF--------GSTAE 778
E L ++ K +++ L+ +K +G PGK PS GS++E
Sbjct: 804 AETLAQVKPSGKTHQ---IRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSE 860
Query: 779 RMRQEGAASQDAALAFRVR-----------------RPASASASEGNPFPRESQGPAPSP 821
+G A A ++ PA A A+ R S+ A S
Sbjct: 861 ESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSS 920
Query: 822 GSLSDDSSSVDSNDSIELEIR----------KFLAEKAKESVSSSEVQAEGPTALGTGGP 871
S S+D + + + IR +A KA + +SS ++ + + G
Sbjct: 921 SSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKES---SRISDG-- 975
Query: 872 ARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLRGTESAGAQGTAGLFSQGGKGLPAAP 931
+K+ P V ++ + + A + +++ AQ +Q G+ +A
Sbjct: 976 -------KKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVAR-TQPSSGVDSAV 1027
Query: 932 ARGDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRGAEPAAKSAFGQLPSCATAGTEAG 991
P+STS V AKG + R+ Q+ + E + S + S +++G+E
Sbjct: 1028 GTLPATSPQSTS--VQAKGTNKLRKPKLPEVQQATKAPESSDDS---EDSSDSSSGSEED 1082
Query: 992 G 992
G
Sbjct: 1083 G 1083
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
sapiens]
Length = 1411
Score = 62.8 bits (151), Expect = 2e-09
Identities = 181/843 (21%), Positives = 285/843 (33%), Gaps = 150/843 (17%)
Query: 293 PRLAKMNVQ------PRSLRSKVTTTQENEGST-----KPAT------------PCRPSE 329
PRLA N P S++ K E G T PAT P + +E
Sbjct: 103 PRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAE 162
Query: 330 AAQN---------KGGIKRSASAARRGKRVMSAAQASEASDSSSDDGIEEAIQLYQLQKT 380
+ N +G + +AA+ G ++SA QA +S+ +S E +++ +K
Sbjct: 163 PSANTTLVSETEEEGSVPAFGAAAKPG--MVSAGQADSSSEDTSSSSDETDVEVKASEKI 220
Query: 381 RKEADGDLPQRVQLREERAPDPP--AHSTSSATKSALPE------------THRKTPSKK 426
+ P + + P PP A + +S TK+ PE + +TP+ K
Sbjct: 221 LQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAK 280
Query: 427 KLVATK----TMDPGPGGLDTDHAPKLLKETKAPPPASPA-SRSEFVERSSCRADTSAEL 481
L+ K T G +P+ P PA ++++ +R +S E
Sbjct: 281 ALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEES 340
Query: 482 MCAEAILDISKTILPAP-VEGSDGSLSASPLFYSPNVPSRSDGDSSSV--------DSDD 532
E +K AP V + SP + P R G +++ DS
Sbjct: 341 DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRS 400
Query: 533 SIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGC 592
S E+ AL A + + + PQ + G PL K P+
Sbjct: 401 SSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMG----------PLGKGAGPV--- 447
Query: 593 KRKRRGGGHVRPSTPK----KMQEVVKDGSQDA-DHSQGRAEPGHERRDLPIQGKASEAL 647
G V P+TP K +E + S+++ D S G G +A
Sbjct: 448 -----PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAK 502
Query: 648 GGEGTARGPGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKL 707
A+GP + + + +D ESSE+ S S DS+E A ++K L
Sbjct: 503 PTSSPAKGPPQ-KAGPVAVQVKAEKPMDNSESSEESSDSADSEE--APAAMTAAQAKPAL 559
Query: 708 KKRCREPRAACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEGPGK 767
K AC KK + + + PV + K + P
Sbjct: 560 K---IPQTKACPKKTNTTASA----------------KVAPVRVGTQAPRKAGTATSPAG 600
Query: 768 KPPSVFGST----AERMRQEGAASQDAALAFRVRRPASASASEGNPFPRES--------Q 815
P+V G T + E + S++ V + S +G S Q
Sbjct: 601 SSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 660
Query: 816 GPAP-SPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQAEGPTALGTGGPARP 874
G AP PG + V + + E + ++ + + S ++V+ PA
Sbjct: 661 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAA 720
Query: 875 EVLCRKEPAPPPG-VCTRSQRA--RGVPHLAEGLRGTESAG--AQGTAGLFSQGGKGLPA 929
K PG V T + +A R + +R +++ A+G A + S G A
Sbjct: 721 RAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATA 780
Query: 930 APARGDPVPPRSTS-------------GGVSAKGLSVSRRNVYVHKDQSPR-GAEPAAKS 975
A A+ P +S V G + R +SPR GA P
Sbjct: 781 AQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPG 840
Query: 976 AFGQLPSCATAGTEAGGARGTFHMGCGSPSFLTPSPGAERDAGAQADRTPPWSDFAHQSR 1035
G PS A AG + GS S + S G A A P F +R
Sbjct: 841 KTG--PSAAQAGKQDDS---------GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNR 889
Query: 1036 LPS 1038
P+
Sbjct: 890 SPA 892
Score = 48.5 bits (114), Expect = 4e-05
Identities = 135/672 (20%), Positives = 234/672 (34%), Gaps = 71/672 (10%)
Query: 83 PAAKPTVHKE--PPALAVCGLVADFDPMGEEETTDFGPLVLDSDSDDSVDRDIEEAIQEY 140
PA+ P+V K A A G D EE ++ L I A+
Sbjct: 767 PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 826
Query: 141 LKA-KSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTALC------PPKLVPG 193
++ + GAA G P AAQ + GS + + G AP A+ PP +
Sbjct: 827 KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 886
Query: 194 SGGGP-GSQVGSSKDQGSASPVSVSSDDSFEQSIRAEIE-----------------QFLN 235
P G ++ Q +++P + +S +S +E E +
Sbjct: 887 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 946
Query: 236 EKRQHETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRL 295
H S+ + E+S S K + P T+V + + A + +
Sbjct: 947 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQK 1006
Query: 296 AKMNVQPRSLRSKVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRGKRVMSAAQ 355
A QP R++ ++ ++ T PAT + S + Q KG K ++ A +
Sbjct: 1007 AS-EAQPPVARTQPSSGVDSAVGTLPATSPQ-STSVQAKGTNKLRKPKLPEVQQATKAPE 1064
Query: 356 ASEASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHST-SSATKSA 414
+S+ S+ SSD + E DG+ PQ + P P T T +
Sbjct: 1065 SSDDSEDSSD------------SSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAE 1112
Query: 415 LPETHRKTPSKKKLVATKTMDPGPGGLDTDHA-PKLLKETKAPPPASPASRSEFVERSSC 473
E PS+ L T P A PKL ++ ++ A++ + +
Sbjct: 1113 SSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKL--DSSPSVSSTLAAKDDPDGKQEA 1170
Query: 474 RADTSAELMC-----AEAILDISKTILPAPVEGSDGSLSASPLFYSPNVPSRSDGDSSSV 528
+ +A ++ EA + P +G+ G+ AS L N+ G +
Sbjct: 1171 KPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGA-GNPQASTLALQSNITQCLLGQPWPL 1229
Query: 529 DSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDP 588
+ ++ L Q + L+ +TP SK
Sbjct: 1230 NEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSK---- 1285
Query: 589 LLGCKRKRRGGGHVRPS--TPKKMQEVVKDGSQDADHSQGRAEPGHERRDLPIQG----K 642
K+K+ G G + +P+K K G D + G + + L QG
Sbjct: 1286 ----KKKKLGAGEGGEASVSPEKTSTTSK-GKAKRDKASGDVKEKKGKGSLGSQGAKDEP 1340
Query: 643 ASEALGGEGTARGPGDTR-MSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLL 701
E G GT G + S+ + K + R+ D+++ + K + S +D ++
Sbjct: 1341 EEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESP----S 1396
Query: 702 RSKRKLKKRCRE 713
+ K+K KK+ E
Sbjct: 1397 QKKKKKKKKTAE 1408
Score = 43.9 bits (102), Expect = 0.001
Identities = 194/980 (19%), Positives = 346/980 (35%), Gaps = 167/980 (17%)
Query: 122 DSDSDD----SVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGA--AQPSRAAGGGSRCKP- 174
DS S+D S + D+E E + A+ P G GA A P +A S+ K
Sbjct: 197 DSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAG 256
Query: 175 ----------EPAHGSAPTALCPPKLVPGSGGGPGSQVGSSKDQGSASPVSVSSDDSFEQ 224
E + S L+ G SQVG++ SP ++ +
Sbjct: 257 KPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK 316
Query: 225 SIRAEIEQFLNEKRQHETQKCD---GSVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLL 281
+ A + + KR+ ++Q S E+ P + S K+ P K R+G
Sbjct: 317 TGPA-VAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKG-- 373
Query: 282 GVQKEFAFRKPPRLAKMNVQPRSLRSKVTTTQENE-GSTKPATPCRPSEAAQNKGGIKRS 340
A PPR P + + +V +E+ S++ + R + AA N +K
Sbjct: 374 ------AAPAPPR----KTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 423
Query: 341 ASAAR-------------RGKRVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRKEADGD 387
+ + +G + + A+ S+ EE + +++ +DG+
Sbjct: 424 GKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSS-EESSDSSDGE 482
Query: 388 LPQRVQLREERAPDP--PAHSTSSATKSALPETHRKTPSKKKLVATKTMDPGPGG----- 440
+P V +E++ A TSS K + P ++ A K MD
Sbjct: 483 VPTAVAPAQEKSLGNILQAKPTSSPAKGP---PQKAGPVAVQVKAEKPMDNSESSEESSD 539
Query: 441 -LDTDHAPKLLKETKAPPPASPASRSEFVERSSCRADTSAELMCAEAILDISKTILPAPV 499
D++ AP + +A P + + +C T+ A + + AP
Sbjct: 540 SADSEEAPAAMTAAQAKPAL------KIPQTKACPKKTNTTASAKVAPVRVGTQ---APR 590
Query: 500 EGSDGSLSASPLFYSPNVPS---RSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGE 556
+ + SP SP V R DSSS + DS E+ +T LA+ + +G
Sbjct: 591 KAGTAT---SPAGSSPAVAGGTQRPAEDSSSSEESDSEEE--KTGLAVTVGQAKSVGKGL 645
Query: 557 SCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGGHVRPSTPKKMQEVVKD 616
+AA P+ K L + P+L K G + QE +
Sbjct: 646 QV-KAASVPV------------KGSLGQGTAPVLPGKT-----GPTVTQVKAEKQEDSES 687
Query: 617 GSQDADHSQGRAEPGHERRDLP-IQGKASEALG----GEGTARGPGDTRMSQGQGKTDEA 671
+++D + A P + + Q KA+ A +GT PG + Q K
Sbjct: 688 SEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSP 747
Query: 672 RRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQTHF 731
++ + S+ L ++ + + + + E + ++ +
Sbjct: 748 SKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE----SDSEEE 803
Query: 732 LEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEG-----PGKKPPSVF--------GSTAE 778
E L ++ K +++ L+ +K +G PGK PS GS++E
Sbjct: 804 AETLAQVKPSGKTHQ---IRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSE 860
Query: 779 RMRQEGAASQDAALAFRVR-----------------RPASASASEGNPFPRESQGPAPSP 821
+G A A ++ PA A A+ R S+ A S
Sbjct: 861 ESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSS 920
Query: 822 GSLSDDSSSVDSNDSIELEIR----------KFLAEKAKESVSSSEVQAEGPTALGTGGP 871
S S+D + + + IR +A KA + +SS ++ + + G
Sbjct: 921 SSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKES---SRISDG-- 975
Query: 872 ARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLRGTESAGAQGTAGLFSQGGKGLPAAP 931
+K+ P V ++ + + A + +++ AQ +Q G+ +A
Sbjct: 976 -------KKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVAR-TQPSSGVDSAV 1027
Query: 932 ARGDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRGAEPAAKSAFGQLPSCATAGTEAG 991
P+STS V AKG + R+ Q+ + E + S + S +++G+E
Sbjct: 1028 GTLPATSPQSTS--VQAKGTNKLRKPKLPEVQQATKAPESSDDS---EDSSDSSSGSEED 1082
Query: 992 GARGTFHMGCGSPSFLTPSP 1011
G G S L P+P
Sbjct: 1083 GEG---PQGAKSAHTLGPTP 1099
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 61.2 bits (147), Expect = 6e-09
Identities = 212/1038 (20%), Positives = 341/1038 (32%), Gaps = 187/1038 (18%)
Query: 66 ERAAQRGHRAEGCHDARPAAKPTVHKEPPALAVCGLVADFDPMGEEETTDFGPLVLDSDS 125
++ ++ G + + DA AK T +P + + ++ + E ET P + ++S
Sbjct: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTSES---SEEEEEAEAETAKATPRLASTNS 110
Query: 126 DDSVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTAL 185
+ D+ +++E KA++ AG P PA G L
Sbjct: 111 S-VLGADLPSSMKEKAKAET------------------EKAGKTGNSMPHPATGKTVANL 151
Query: 186 CPPKLVPGSGGGPGSQ---VGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQHET 242
K P P + V ++++GS ++ + +A+ ET
Sbjct: 152 LSGKS-PRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDET 210
Query: 243 QKCDGSVEKKPDTNENSAK-SLLKSHQEPPTKVVHRQGLLG--VQKEFAFRKPPRLAKMN 299
VE KP K S + + + P K G +G + PP
Sbjct: 211 D-----VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKK 265
Query: 300 VQPRSLRSKVTTTQENEGSTKPATPCRPSE--------AAQNKGGIKRSASAARRGKRVM 351
+ S S+ + E E + + SE +A KG + A+ A GK
Sbjct: 266 PEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGA 325
Query: 352 SAAQA--------SEASDSSSDDGIEEA------IQLYQLQKTRKEADGDLPQRVQLREE 397
A+Q SE+S S D EE +Q KT + P + R+
Sbjct: 326 VASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKG 385
Query: 398 RAPDPPAHSTSSATKSALPETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAPP 457
AP PP + + K+ + + S + ++D E +AP
Sbjct: 386 AAPAPPGKTGPAVAKAQAGKREEDSQSSSE--------------ESD------SEEEAPA 425
Query: 458 PASPASRSEFVERSSCRADTSAELMCAEAILDISKTILPAPVEGSDGSLSASPLFYSPNV 517
A P+ ++ V +S A S K PAP + G +A
Sbjct: 426 QAKPSGKAPQVRAASAPAKESPR-----------KGAAPAPPRKT-GPAAAQVQVGKQEE 473
Query: 518 PSRSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGG 577
SRS + S D + AL A + + + PQ + G
Sbjct: 474 DSRSSSEESDSDRE-----------ALAAMNAAQVKPLGKSPQVKPASTMGMG------- 515
Query: 578 HKTPLSKTPDPLLGCKRKRRGGGHVRPSTPK----KMQEVVKDGSQDA-DHSQGRAEPGH 632
PL K P+ G V P+TP K +E + S+++ D S G
Sbjct: 516 ---PLGKGAGPV--------PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAV 564
Query: 633 ERRDLPIQGKASEALGGEGTARGPGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDED 692
G +A A+GP + + + +D ESSE+ S S DS+E
Sbjct: 565 APAQEKSLGNILQAKPTSSPAKGPPQ-KAGPVAVQVKAEKPMDNSESSEESSDSADSEE- 622
Query: 693 LDTAIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKS 752
A ++K LK AC KK + + + PV
Sbjct: 623 -APAAMTAAQAKPALK---IPQTKACPKKTNTTASA----------------KVAPVRVG 662
Query: 753 CLSKSKRDSGEGPGKKPPSVFGST----AERMRQEGAASQDAALAFRVRRPASASASEGN 808
+ K + P P+V G T + E + S++ V + S +G
Sbjct: 663 TQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGL 722
Query: 809 PFPRES--------QGPAP-SPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQ 859
S QG AP PG + V + + E + ++ + + S ++V+
Sbjct: 723 QVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVK 782
Query: 860 AEGPTALGTGGPARPEVLCRKEPAPPPG-VCTRSQRA--RGVPHLAEGLRGTESAG--AQ 914
PA K PG V T + +A R + +R +++ A+
Sbjct: 783 TSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLAR 842
Query: 915 GTAGLFSQGGKGLPAAPARGDPVPPRSTS-------------GGVSAKGLSVSRRNVYVH 961
G A + S G AA A+ P +S V G + R
Sbjct: 843 GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP 902
Query: 962 KDQSPR-GAEPAAKSAFGQLPSCATAGTEAGGARGTFHMGCGSPSFLTPSPGAERDAGAQ 1020
+SPR GA P G PS A AG + GS S + S G A
Sbjct: 903 AKESPRKGAAPTPPGKTG--PSAAQAGKQDDS---------GSSSEESDSDGEAPAAVTS 951
Query: 1021 ADRTPPWSDFAHQSRLPS 1038
A P F +R P+
Sbjct: 952 AQVIKPPLIFVDPNRSPA 969
Score = 38.9 bits (89), Expect = 0.030
Identities = 122/659 (18%), Positives = 227/659 (34%), Gaps = 82/659 (12%)
Query: 83 PAAKPTVHKE--PPALAVCGLVADFDPMGEEETTDFGPLVLDSDSDDSVDRDIEEAIQEY 140
PA+ P+V K A A G D EE ++ L I A+
Sbjct: 844 PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 903
Query: 141 LKA-KSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTALC------PPKLVPG 193
++ + GAA G P AAQ + GS + + G AP A+ PP +
Sbjct: 904 KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 963
Query: 194 SGGGP-GSQVGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQHETQKCDGSVEKK 252
P G ++ Q +++P + +S +S +E E +E TQ +
Sbjct: 964 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESE---DEDVIPATQCLTPGI--- 1017
Query: 253 PDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRLAKMNVQPRSLRSKVTTT 312
+ ++ +H R P+ + S+++
Sbjct: 1018 ----RTNVVTMPTAHP---------------------RIAPKASMAGASSSKESSRISDG 1052
Query: 313 QENEG---STKPATPCRPSEAAQNKGGIKRSASAARRGK--RVMSAAQASEASDSSSDDG 367
++ EG A P+ + Q+ + + R+ K V A +A E+SD S D
Sbjct: 1053 KKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1112
Query: 368 IEEAIQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHSTSSATKSALPETHRKTPSKKK 427
+ E DG+ PQ + P+ + + ++A + + +
Sbjct: 1113 D---------SSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQ 1163
Query: 428 LVATKTMDPGPGGLDTDHAPKLLKETKAPPPASP-ASRSEFVERSSCRADTSAELMC--- 483
+ + M PG ++ + K +P +S A++ + + + +A ++
Sbjct: 1164 SLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKT 1223
Query: 484 --AEAILDISKTILPAPVEGSDGSLSASPLFYSPNVPSRSDGDSSSVDSDDSIEQEIRTF 541
EA + P +G+ G+ AS L N+ G ++ ++
Sbjct: 1224 GGKEAASGTTPQKSRKPKKGA-GNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVL 1282
Query: 542 LALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGGH 601
L Q + L+ +TP SK K+K+ G G
Sbjct: 1283 TELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSK--------KKKKLGAGE 1334
Query: 602 VRPS--TPKKMQEVVKDGSQDADHSQGRAEPGHERRDLPIQG----KASEALGGEGTARG 655
+ +P+K K G D + G + + L QG E G GT G
Sbjct: 1335 GGEASVSPEKTSTTSK-GKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEG 1393
Query: 656 PGDTR-MSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCRE 713
+ S+ + K + R+ D+++ + K + S +D ++ + K+K KK+ E
Sbjct: 1394 GDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESP----SQKKKKKKKKTAE 1448
Score = 36.2 bits (82), Expect = 0.19
Identities = 154/817 (18%), Positives = 267/817 (32%), Gaps = 165/817 (20%)
Query: 142 KAKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAP------------TALCPPK 189
+ K GA P +P + S ++ GS + E G+ A P K
Sbjct: 251 QVKGGALPPAKRAKKP--EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAK 308
Query: 190 LVPGSGGGPG--SQVGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQHETQKCDG 247
PG G P + G+ Q A S+ S E+S +E ET
Sbjct: 309 GTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE----------EETPAAKA 358
Query: 248 SVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRLAKMNVQPRSLRS 307
++ K + + +E P K G + P +AK R S
Sbjct: 359 LLQAKASGKTSQVGAASAPAKESPRK--------GAAPAPPGKTGPAVAKAQAGKREEDS 410
Query: 308 KVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRG-------KRVMSAAQAS--- 357
+ ++ + + PA +A Q + + + R+G K +AAQ
Sbjct: 411 QSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGK 470
Query: 358 --EASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQ--------RVQLREERAPDPPAHST 407
E S SSS++ + L + + + G PQ L + P PP
Sbjct: 471 QEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVG 530
Query: 408 SSATKSALPETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKLLKET----KAPPPASPAS 463
+ + + + + S + ++ D G + T AP K +A P +SPA
Sbjct: 531 PATPSAQVGKWEEDSESSSE----ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAK 586
Query: 464 --------------------RSEFVERSSCRADTS---AELMCAEA--ILDISKTILPAP 498
SE E SS AD+ A + A+A L I +T
Sbjct: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPK 646
Query: 499 VEGSDGSLSASPLFYSPNVPSRSDGDSS------------------SVDSDDSIEQEIRT 540
+ S +P+ P ++ +S S S++S +E +T
Sbjct: 647 KTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKT 706
Query: 541 FLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGG 600
LA+ + +G +AA P+ K L + P+L K G
Sbjct: 707 GLAVTVGQAKSVGKGLQV-KAASVPV------------KGSLGQGTAPVLPGKT-----G 748
Query: 601 HVRPSTPKKMQEVVKDGSQDADHSQGRAEPGHERRDLP-IQGKASEALG----GEGTARG 655
+ QE + +++D + A P + + Q KA+ A +GT
Sbjct: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA 808
Query: 656 PGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPR 715
PG + Q K ++ + S+ L ++ + + + + E
Sbjct: 809 PGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDS 868
Query: 716 AACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEG-----PGKKPP 770
+ ++ + E L ++ K +++ L+ +K +G PGK P
Sbjct: 869 GSSEEE----SDSEEEAETLAQVKPSGKTHQ---IRAALAPAKESPRKGAAPTPPGKTGP 921
Query: 771 SVF--------GSTAERMRQEGAASQDAALAFRVR-----------------RPASASAS 805
S GS++E +G A A ++ PA A A+
Sbjct: 922 SAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAA 981
Query: 806 EGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEIR 842
R S+ A S S S+D + + + IR
Sbjct: 982 STPRKARASESTARSSSSESEDEDVIPATQCLTPGIR 1018
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 61.2 bits (147), Expect = 6e-09
Identities = 212/1038 (20%), Positives = 341/1038 (32%), Gaps = 187/1038 (18%)
Query: 66 ERAAQRGHRAEGCHDARPAAKPTVHKEPPALAVCGLVADFDPMGEEETTDFGPLVLDSDS 125
++ ++ G + + DA AK T +P + + ++ + E ET P + ++S
Sbjct: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTSES---SEEEEEAEAETAKATPRLASTNS 110
Query: 126 DDSVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTAL 185
+ D+ +++E KA++ AG P PA G L
Sbjct: 111 S-VLGADLPSSMKEKAKAET------------------EKAGKTGNSMPHPATGKTVANL 151
Query: 186 CPPKLVPGSGGGPGSQ---VGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQHET 242
K P P + V ++++GS ++ + +A+ ET
Sbjct: 152 LSGKS-PRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDET 210
Query: 243 QKCDGSVEKKPDTNENSAK-SLLKSHQEPPTKVVHRQGLLG--VQKEFAFRKPPRLAKMN 299
VE KP K S + + + P K G +G + PP
Sbjct: 211 D-----VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKK 265
Query: 300 VQPRSLRSKVTTTQENEGSTKPATPCRPSE--------AAQNKGGIKRSASAARRGKRVM 351
+ S S+ + E E + + SE +A KG + A+ A GK
Sbjct: 266 PEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGA 325
Query: 352 SAAQA--------SEASDSSSDDGIEEA------IQLYQLQKTRKEADGDLPQRVQLREE 397
A+Q SE+S S D EE +Q KT + P + R+
Sbjct: 326 VASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKG 385
Query: 398 RAPDPPAHSTSSATKSALPETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAPP 457
AP PP + + K+ + + S + ++D E +AP
Sbjct: 386 AAPAPPGKTGPAVAKAQAGKREEDSQSSSE--------------ESD------SEEEAPA 425
Query: 458 PASPASRSEFVERSSCRADTSAELMCAEAILDISKTILPAPVEGSDGSLSASPLFYSPNV 517
A P+ ++ V +S A S K PAP + G +A
Sbjct: 426 QAKPSGKAPQVRAASAPAKESPR-----------KGAAPAPPRKT-GPAAAQVQVGKQEE 473
Query: 518 PSRSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGG 577
SRS + S D + AL A + + + PQ + G
Sbjct: 474 DSRSSSEESDSDRE-----------ALAAMNAAQVKPLGKSPQVKPASTMGMG------- 515
Query: 578 HKTPLSKTPDPLLGCKRKRRGGGHVRPSTPK----KMQEVVKDGSQDA-DHSQGRAEPGH 632
PL K P+ G V P+TP K +E + S+++ D S G
Sbjct: 516 ---PLGKGAGPV--------PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAV 564
Query: 633 ERRDLPIQGKASEALGGEGTARGPGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDED 692
G +A A+GP + + + +D ESSE+ S S DS+E
Sbjct: 565 APAQEKSLGNILQAKPTSSPAKGPPQ-KAGPVAVQVKAEKPMDNSESSEESSDSADSEE- 622
Query: 693 LDTAIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKS 752
A ++K LK AC KK + + + PV
Sbjct: 623 -APAAMTAAQAKPALK---IPQTKACPKKTNTTASA----------------KVAPVRVG 662
Query: 753 CLSKSKRDSGEGPGKKPPSVFGST----AERMRQEGAASQDAALAFRVRRPASASASEGN 808
+ K + P P+V G T + E + S++ V + S +G
Sbjct: 663 TQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGL 722
Query: 809 PFPRES--------QGPAP-SPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQ 859
S QG AP PG + V + + E + ++ + + S ++V+
Sbjct: 723 QVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVK 782
Query: 860 AEGPTALGTGGPARPEVLCRKEPAPPPG-VCTRSQRA--RGVPHLAEGLRGTESAG--AQ 914
PA K PG V T + +A R + +R +++ A+
Sbjct: 783 TSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLAR 842
Query: 915 GTAGLFSQGGKGLPAAPARGDPVPPRSTS-------------GGVSAKGLSVSRRNVYVH 961
G A + S G AA A+ P +S V G + R
Sbjct: 843 GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP 902
Query: 962 KDQSPR-GAEPAAKSAFGQLPSCATAGTEAGGARGTFHMGCGSPSFLTPSPGAERDAGAQ 1020
+SPR GA P G PS A AG + GS S + S G A
Sbjct: 903 AKESPRKGAAPTPPGKTG--PSAAQAGKQDDS---------GSSSEESDSDGEAPAAVTS 951
Query: 1021 ADRTPPWSDFAHQSRLPS 1038
A P F +R P+
Sbjct: 952 AQVIKPPLIFVDPNRSPA 969
Score = 48.5 bits (114), Expect = 4e-05
Identities = 135/672 (20%), Positives = 234/672 (34%), Gaps = 71/672 (10%)
Query: 83 PAAKPTVHKE--PPALAVCGLVADFDPMGEEETTDFGPLVLDSDSDDSVDRDIEEAIQEY 140
PA+ P+V K A A G D EE ++ L I A+
Sbjct: 844 PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 903
Query: 141 LKA-KSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTALC------PPKLVPG 193
++ + GAA G P AAQ + GS + + G AP A+ PP +
Sbjct: 904 KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 963
Query: 194 SGGGP-GSQVGSSKDQGSASPVSVSSDDSFEQSIRAEIE-----------------QFLN 235
P G ++ Q +++P + +S +S +E E +
Sbjct: 964 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023
Query: 236 EKRQHETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRL 295
H S+ + E+S S K + P T+V + + A + +
Sbjct: 1024 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQK 1083
Query: 296 AKMNVQPRSLRSKVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRGKRVMSAAQ 355
A QP R++ ++ ++ T PAT + S + Q KG K ++ A +
Sbjct: 1084 AS-EAQPPVARTQPSSGVDSAVGTLPATSPQ-STSVQAKGTNKLRKPKLPEVQQATKAPE 1141
Query: 356 ASEASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHST-SSATKSA 414
+S+ S+ SSD + E DG+ PQ + P P T T +
Sbjct: 1142 SSDDSEDSSD------------SSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAE 1189
Query: 415 LPETHRKTPSKKKLVATKTMDPGPGGLDTDHA-PKLLKETKAPPPASPASRSEFVERSSC 473
E PS+ L T P A PKL ++ ++ A++ + +
Sbjct: 1190 SSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKL--DSSPSVSSTLAAKDDPDGKQEA 1247
Query: 474 RADTSAELMC-----AEAILDISKTILPAPVEGSDGSLSASPLFYSPNVPSRSDGDSSSV 528
+ +A ++ EA + P +G+ G+ AS L N+ G +
Sbjct: 1248 KPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGA-GNPQASTLALQSNITQCLLGQPWPL 1306
Query: 529 DSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDP 588
+ ++ L Q + L+ +TP SK
Sbjct: 1307 NEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSK---- 1362
Query: 589 LLGCKRKRRGGGHVRPS--TPKKMQEVVKDGSQDADHSQGRAEPGHERRDLPIQG----K 642
K+K+ G G + +P+K K G D + G + + L QG
Sbjct: 1363 ----KKKKLGAGEGGEASVSPEKTSTTSK-GKAKRDKASGDVKEKKGKGSLGSQGAKDEP 1417
Query: 643 ASEALGGEGTARGPGDTR-MSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLL 701
E G GT G + S+ + K + R+ D+++ + K + S +D ++
Sbjct: 1418 EEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESP----S 1473
Query: 702 RSKRKLKKRCRE 713
+ K+K KK+ E
Sbjct: 1474 QKKKKKKKKTAE 1485
Score = 40.4 bits (93), Expect = 0.010
Identities = 190/996 (19%), Positives = 335/996 (33%), Gaps = 196/996 (19%)
Query: 142 KAKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAP------------TALCPPK 189
+ K GA P +P + S ++ GS + E G+ A P K
Sbjct: 251 QVKGGALPPAKRAKKP--EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAK 308
Query: 190 LVPGSGGGPG--SQVGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQHETQKCDG 247
PG G P + G+ Q A S+ S E+S +E ET
Sbjct: 309 GTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE----------EETPAAKA 358
Query: 248 SVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRLAKMNVQPRSLRS 307
++ K + + +E P K G + P +AK R S
Sbjct: 359 LLQAKASGKTSQVGAASAPAKESPRK--------GAAPAPPGKTGPAVAKAQAGKREEDS 410
Query: 308 KVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRG-------KRVMSAAQAS--- 357
+ ++ + + PA +A Q + + + R+G K +AAQ
Sbjct: 411 QSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGK 470
Query: 358 --EASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQ--------RVQLREERAPDPPAHST 407
E S SSS++ + L + + + G PQ L + P PP
Sbjct: 471 QEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVG 530
Query: 408 SSATKSALPETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKLLKET----KAPPPASPAS 463
+ + + + + S + ++ D G + T AP K +A P +SPA
Sbjct: 531 PATPSAQVGKWEEDSESSSE----ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAK 586
Query: 464 --------------------RSEFVERSSCRADTS---AELMCAEA--ILDISKTILPAP 498
SE E SS AD+ A + A+A L I +T
Sbjct: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPK 646
Query: 499 VEGSDGSLSASPLFYSPNVPSRSDGDSS------------------SVDSDDSIEQEIRT 540
+ S +P+ P ++ +S S S++S +E +T
Sbjct: 647 KTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKT 706
Query: 541 FLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGG 600
LA+ + +G +AA P+ K L + P+L K G
Sbjct: 707 GLAVTVGQAKSVGKGLQV-KAASVPV------------KGSLGQGTAPVLPGKT-----G 748
Query: 601 HVRPSTPKKMQEVVKDGSQDADHSQGRAEPGHERRDLP-IQGKASEALG----GEGTARG 655
+ QE + +++D + A P + + Q KA+ A +GT
Sbjct: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA 808
Query: 656 PGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPR 715
PG + Q K ++ + S+ L ++ + + + + E
Sbjct: 809 PGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDS 868
Query: 716 AACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEG-----PGKKPP 770
+ ++ + E L ++ K +++ L+ +K +G PGK P
Sbjct: 869 GSSEEE----SDSEEEAETLAQVKPSGKTHQ---IRAALAPAKESPRKGAAPTPPGKTGP 921
Query: 771 SVF--------GSTAERMRQEGAASQDAALAFRVR-----------------RPASASAS 805
S GS++E +G A A ++ PA A A+
Sbjct: 922 SAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAA 981
Query: 806 EGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEIR----------KFLAEKAKESVSS 855
R S+ A S S S+D + + + IR +A KA + +S
Sbjct: 982 STPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGAS 1041
Query: 856 SEVQAEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLRGTESAGAQG 915
S ++ + + G +K+ P V ++ + + A + +++ AQ
Sbjct: 1042 SSKES---SRISDG---------KKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP 1089
Query: 916 TAGLFSQGGKGLPAAPARGDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRGAEPAAKS 975
+Q G+ +A P+STS V AKG + R+ Q+ + E + S
Sbjct: 1090 PVAR-TQPSSGVDSAVGTLPATSPQSTS--VQAKGTNKLRKPKLPEVQQATKAPESSDDS 1146
Query: 976 AFGQLPSCATAGTEAGGARGTFHMGCGSPSFLTPSP 1011
+ S +++G+E G G S L P+P
Sbjct: 1147 ---EDSSDSSSGSEEDGEG---PQGAKSAHTLGPTP 1176
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 61.2 bits (147), Expect = 6e-09
Identities = 212/1038 (20%), Positives = 341/1038 (32%), Gaps = 187/1038 (18%)
Query: 66 ERAAQRGHRAEGCHDARPAAKPTVHKEPPALAVCGLVADFDPMGEEETTDFGPLVLDSDS 125
++ ++ G + + DA AK T +P + + ++ + E ET P + ++S
Sbjct: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTSES---SEEEEEAEAETAKATPRLASTNS 110
Query: 126 DDSVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTAL 185
+ D+ +++E KA++ AG P PA G L
Sbjct: 111 S-VLGADLPSSMKEKAKAET------------------EKAGKTGNSMPHPATGKTVANL 151
Query: 186 CPPKLVPGSGGGPGSQ---VGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQHET 242
K P P + V ++++GS ++ + +A+ ET
Sbjct: 152 LSGKS-PRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDET 210
Query: 243 QKCDGSVEKKPDTNENSAK-SLLKSHQEPPTKVVHRQGLLG--VQKEFAFRKPPRLAKMN 299
VE KP K S + + + P K G +G + PP
Sbjct: 211 D-----VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKK 265
Query: 300 VQPRSLRSKVTTTQENEGSTKPATPCRPSE--------AAQNKGGIKRSASAARRGKRVM 351
+ S S+ + E E + + SE +A KG + A+ A GK
Sbjct: 266 PEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGA 325
Query: 352 SAAQA--------SEASDSSSDDGIEEA------IQLYQLQKTRKEADGDLPQRVQLREE 397
A+Q SE+S S D EE +Q KT + P + R+
Sbjct: 326 VASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKG 385
Query: 398 RAPDPPAHSTSSATKSALPETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAPP 457
AP PP + + K+ + + S + ++D E +AP
Sbjct: 386 AAPAPPGKTGPAVAKAQAGKREEDSQSSSE--------------ESD------SEEEAPA 425
Query: 458 PASPASRSEFVERSSCRADTSAELMCAEAILDISKTILPAPVEGSDGSLSASPLFYSPNV 517
A P+ ++ V +S A S K PAP + G +A
Sbjct: 426 QAKPSGKAPQVRAASAPAKESPR-----------KGAAPAPPRKT-GPAAAQVQVGKQEE 473
Query: 518 PSRSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGG 577
SRS + S D + AL A + + + PQ + G
Sbjct: 474 DSRSSSEESDSDRE-----------ALAAMNAAQVKPLGKSPQVKPASTMGMG------- 515
Query: 578 HKTPLSKTPDPLLGCKRKRRGGGHVRPSTPK----KMQEVVKDGSQDA-DHSQGRAEPGH 632
PL K P+ G V P+TP K +E + S+++ D S G
Sbjct: 516 ---PLGKGAGPV--------PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAV 564
Query: 633 ERRDLPIQGKASEALGGEGTARGPGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDED 692
G +A A+GP + + + +D ESSE+ S S DS+E
Sbjct: 565 APAQEKSLGNILQAKPTSSPAKGPPQ-KAGPVAVQVKAEKPMDNSESSEESSDSADSEE- 622
Query: 693 LDTAIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKS 752
A ++K LK AC KK + + + PV
Sbjct: 623 -APAAMTAAQAKPALK---IPQTKACPKKTNTTASA----------------KVAPVRVG 662
Query: 753 CLSKSKRDSGEGPGKKPPSVFGST----AERMRQEGAASQDAALAFRVRRPASASASEGN 808
+ K + P P+V G T + E + S++ V + S +G
Sbjct: 663 TQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGL 722
Query: 809 PFPRES--------QGPAP-SPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQ 859
S QG AP PG + V + + E + ++ + + S ++V+
Sbjct: 723 QVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVK 782
Query: 860 AEGPTALGTGGPARPEVLCRKEPAPPPG-VCTRSQRA--RGVPHLAEGLRGTESAG--AQ 914
PA K PG V T + +A R + +R +++ A+
Sbjct: 783 TSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLAR 842
Query: 915 GTAGLFSQGGKGLPAAPARGDPVPPRSTS-------------GGVSAKGLSVSRRNVYVH 961
G A + S G AA A+ P +S V G + R
Sbjct: 843 GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP 902
Query: 962 KDQSPR-GAEPAAKSAFGQLPSCATAGTEAGGARGTFHMGCGSPSFLTPSPGAERDAGAQ 1020
+SPR GA P G PS A AG + GS S + S G A
Sbjct: 903 AKESPRKGAAPTPPGKTG--PSAAQAGKQDDS---------GSSSEESDSDGEAPAAVTS 951
Query: 1021 ADRTPPWSDFAHQSRLPS 1038
A P F +R P+
Sbjct: 952 AQVIKPPLIFVDPNRSPA 969
Score = 38.9 bits (89), Expect = 0.030
Identities = 128/660 (19%), Positives = 224/660 (33%), Gaps = 85/660 (12%)
Query: 83 PAAKPTVHKE--PPALAVCGLVADFDPMGEEETTDFGPLVLDSDSDDSVDRDIEEAIQEY 140
PA+ P+V K A A G D EE ++ L I A+
Sbjct: 844 PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 903
Query: 141 LKA-KSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTALC------PPKLVPG 193
++ + GAA G P AAQ + GS + + G AP A+ PP +
Sbjct: 904 KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 963
Query: 194 SGGGP-GSQVGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQHETQKCDGSVEKK 252
P G ++ Q +++P + +S +S +E E +E TQ +
Sbjct: 964 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESE---DEDVIPATQCLTPGI--- 1017
Query: 253 PDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRLAKMNVQPRSLRSKVTTT 312
+ ++ +H R P+ + S+++
Sbjct: 1018 ----RTNVVTMPTAHP---------------------RIAPKASMAGASSSKESSRISDG 1052
Query: 313 QENEG---STKPATPCRPSEAAQNKGGIKRSASAARRGK--RVMSAAQASEASDSSSDDG 367
++ EG A P+ + Q+ + + R+ K V A +A E+SD S D
Sbjct: 1053 KKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1112
Query: 368 IEEAIQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHST-SSATKSALPETHRKTPSKK 426
+ E DG+ PQ + P P T T + E PS+
Sbjct: 1113 D---------SSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQS 1163
Query: 427 KLVATKTMDPGPGGLDTDHA-PKLLKETKAPPPASPASRSEFVERSSCRADTSAELMC-- 483
L T P A PKL ++ ++ A++ + + + +A ++
Sbjct: 1164 LLSGYMTPGLTPANSQASKATPKL--DSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPK 1221
Query: 484 ---AEAILDISKTILPAPVEGSDGSLSASPLFYSPNVPSRSDGDSSSVDSDDSIEQEIRT 540
EA + P +G+ G+ AS L N+ G ++ ++
Sbjct: 1222 TGGKEAASGTTPQKSRKPKKGA-GNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKV 1280
Query: 541 FLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGG 600
L Q + L+ +TP SK K+K+ G G
Sbjct: 1281 LTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSK--------KKKKLGAG 1332
Query: 601 HVRPS--TPKKMQEVVKDGSQDADHSQGRAEPGHERRDLPIQG----KASEALGGEGTAR 654
+ +P+K K G D + G + + L QG E G GT
Sbjct: 1333 EGGEASVSPEKTSTTSK-GKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVE 1391
Query: 655 GPGDTR-MSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCRE 713
G + S+ + K + R+ D+++ + K + S +D ++ + K+K KK+ E
Sbjct: 1392 GGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESP----SQKKKKKKKKTAE 1447
Score = 36.2 bits (82), Expect = 0.19
Identities = 154/817 (18%), Positives = 267/817 (32%), Gaps = 165/817 (20%)
Query: 142 KAKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAP------------TALCPPK 189
+ K GA P +P + S ++ GS + E G+ A P K
Sbjct: 251 QVKGGALPPAKRAKKP--EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAK 308
Query: 190 LVPGSGGGPG--SQVGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQHETQKCDG 247
PG G P + G+ Q A S+ S E+S +E ET
Sbjct: 309 GTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE----------EETPAAKA 358
Query: 248 SVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRLAKMNVQPRSLRS 307
++ K + + +E P K G + P +AK R S
Sbjct: 359 LLQAKASGKTSQVGAASAPAKESPRK--------GAAPAPPGKTGPAVAKAQAGKREEDS 410
Query: 308 KVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRG-------KRVMSAAQAS--- 357
+ ++ + + PA +A Q + + + R+G K +AAQ
Sbjct: 411 QSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGK 470
Query: 358 --EASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQ--------RVQLREERAPDPPAHST 407
E S SSS++ + L + + + G PQ L + P PP
Sbjct: 471 QEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVG 530
Query: 408 SSATKSALPETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKLLKET----KAPPPASPAS 463
+ + + + + S + ++ D G + T AP K +A P +SPA
Sbjct: 531 PATPSAQVGKWEEDSESSSE----ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAK 586
Query: 464 --------------------RSEFVERSSCRADTS---AELMCAEA--ILDISKTILPAP 498
SE E SS AD+ A + A+A L I +T
Sbjct: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPK 646
Query: 499 VEGSDGSLSASPLFYSPNVPSRSDGDSS------------------SVDSDDSIEQEIRT 540
+ S +P+ P ++ +S S S++S +E +T
Sbjct: 647 KTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKT 706
Query: 541 FLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGG 600
LA+ + +G +AA P+ K L + P+L K G
Sbjct: 707 GLAVTVGQAKSVGKGLQV-KAASVPV------------KGSLGQGTAPVLPGKT-----G 748
Query: 601 HVRPSTPKKMQEVVKDGSQDADHSQGRAEPGHERRDLP-IQGKASEALG----GEGTARG 655
+ QE + +++D + A P + + Q KA+ A +GT
Sbjct: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA 808
Query: 656 PGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPR 715
PG + Q K ++ + S+ L ++ + + + + E
Sbjct: 809 PGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDS 868
Query: 716 AACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEG-----PGKKPP 770
+ ++ + E L ++ K +++ L+ +K +G PGK P
Sbjct: 869 GSSEEE----SDSEEEAETLAQVKPSGKTHQ---IRAALAPAKESPRKGAAPTPPGKTGP 921
Query: 771 SVF--------GSTAERMRQEGAASQDAALAFRVR-----------------RPASASAS 805
S GS++E +G A A ++ PA A A+
Sbjct: 922 SAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAA 981
Query: 806 EGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEIR 842
R S+ A S S S+D + + + IR
Sbjct: 982 STPRKARASESTARSSSSESEDEDVIPATQCLTPGIR 1018
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 60.8 bits (146), Expect = 7e-09
Identities = 123/574 (21%), Positives = 207/574 (36%), Gaps = 90/574 (15%)
Query: 181 APTALCPPKLV---PGSGGGPGSQVGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEK 237
A A P K V PG S+ SS++ SSDD E+ + + Q K
Sbjct: 102 AKKAAVPAKRVGLPPGKAAAKASESSSSEE---------SSDDDDEEDQKKQPVQ-KGVK 151
Query: 238 RQHETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRLAK 297
Q + K K D++ +S+ S EPP + + V + + PP+ A+
Sbjct: 152 PQAKAAKAPPKKAKSSDSDSDSS-----SEDEPPKN--QKPKITPVTVKAQTKAPPKPAR 204
Query: 298 MNVQPRSLRSKVTTTQENEGSTKPATPCRPSEAAQN--KGGIKRSASAARRGKRVMSAAQ 355
P+ K ++ + S+ + +AA K K+ A K + +
Sbjct: 205 --AAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTR 262
Query: 356 ASEASDSSSDDGIEEAIQLYQLQ------------KTRKEADGDLPQRVQLREERAPDPP 403
S +S+ SS D EE + + + K++ G P + + +++ P
Sbjct: 263 KSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQ---PV 319
Query: 404 AHSTSSATKSALPETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAPPPASPAS 463
S S+ +S K P K +V+ T P P K ++ +S +
Sbjct: 320 ESSEDSSDESDSSSEEEKKPPTKAVVSKATTKP----------PPAKKAAESSSDSSDSD 369
Query: 464 RSEFVERSSCRADTSAELMCAEAILDISKTILPA-----PVEGSDGSLSASPLFYSPNVP 518
SE E S A T+ A+ S + PA PV G L+
Sbjct: 370 SSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLT----------- 418
Query: 519 SRSDGDSSSVDSDDSIEQEIRTFLA-LKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGG 577
++D SS +S S E++ + +A K ++ + A QA QG +S +
Sbjct: 419 RKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGS-RDSSSDSDSSS 477
Query: 578 HKTPLSKTPDPLLGCKRKRRGGGHVRPSTPKKMQEVVKDGSQDADHSQGRAEPGHERRDL 637
+ KT + K ++ GG PS P A +G+AE +
Sbjct: 478 SEEEEEKTSKSAVKKKPQKVAGG-AAPSKP-------------ASAKKGKAESSNSSSSD 523
Query: 638 PIQGKASEALGGEGTAR--GPGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDT 695
+ E L G+G+ R P S + +A + E+E E K +++
Sbjct: 524 DSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAV-------V 576
Query: 696 AIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQT 729
K KRK + +E KK++ T T
Sbjct: 577 VSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNT 610
Score = 35.8 bits (81), Expect = 0.25
Identities = 76/365 (20%), Positives = 132/365 (36%), Gaps = 36/365 (9%)
Query: 517 VPSRSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTG 576
V ++ +SS DS+DS E+E + A+ + P G LPPG +
Sbjct: 74 VAKKAKKKASSSDSEDSSEEE--------EEVQGPPAKKAAVPAKRVG--LPPGKAAAKA 123
Query: 577 GHKTPLSKTPDPLLGCKRKRRG---GGHVRPSTPKKMQEVVKDGSQDADHSQGRAEPGHE 633
+ ++ D +K++ G + K + K D+D S P ++
Sbjct: 124 SESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQ 183
Query: 634 RRDL-PIQGKASEALGGEGTARGPGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDED 692
+ + P+ KA T P R + K + SS SSS DS+E+
Sbjct: 184 KPKITPVTVKAQ-------TKAPPKPARAAP---KIANGKAASSSSSSSSSSSSDDSEEE 233
Query: 693 LDTAIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPP---V 749
A K+++ + +AA + S+++ ++ ++ K++ P V
Sbjct: 234 KAAATPKKTVPKKQVVAKA-PVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSV 292
Query: 750 LKSCLSKSKRDSGEGPGKKPPSVFGSTAERMRQEGAASQDAALAFRVRRPASASASEGNP 809
K+ G P KK +V ++ + D++ + P A S+
Sbjct: 293 PPPSAPPPKKSLGTQPPKK--AVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATT 350
Query: 810 FPRESQGPAPSPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQAEGPTALGTG 869
P PA S DSS DS+ S + E A K S + V + P
Sbjct: 351 KPP----PAKKAAESSSDSS--DSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAA 404
Query: 870 GPARP 874
P +P
Sbjct: 405 APKQP 409
Score = 35.0 bits (79), Expect = 0.43
Identities = 64/315 (20%), Positives = 109/315 (34%), Gaps = 38/315 (12%)
Query: 118 PLVLDSDSDDSVDRDIEEAIQEYLKA---KSGAAQPGAGGAQPGAAQ------------P 162
P+ DS D D EE + KA K+ P A A ++ P
Sbjct: 318 PVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAP 377
Query: 163 SRAAGGGSRCKPEPAHGSAPTALCPPKLVPGSGGGPGSQVGSSKDQGSASPVSVSSDDSF 222
S+ AG +PA + A+ P P VG + + S SS++
Sbjct: 378 SKPAGTTKNSSNKPAVTTKSPAVKP-------AAAPKQPVGGGQKLLTRKADSSSSEEES 430
Query: 223 EQSIRAEIEQFLNEKRQHETQKCDGSVEKKP------DTNENSAKSLLKSHQEPPTKVVH 276
S + ++ + + T K S+ K D++ +S S + +E +K
Sbjct: 431 SSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAV 490
Query: 277 RQGLLGVQKEFAFRKPPRLAKMNVQPRSLRSKVTTTQENE------GSTKPATPCRPSEA 330
++ V A KP K + + S +++E E GS +P P +
Sbjct: 491 KKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTS 550
Query: 331 ---AQNKGGIKRSASAARRGKRVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRKEADGD 387
AQN K S K+ S + + + + Q +K + +
Sbjct: 551 ALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNT 610
Query: 388 LPQRVQLREERAPDP 402
P+R + E+RA P
Sbjct: 611 FPKR-KKGEKRASSP 624
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 60.8 bits (146), Expect = 7e-09
Identities = 201/989 (20%), Positives = 327/989 (33%), Gaps = 178/989 (17%)
Query: 66 ERAAQRGHRAEGCHDARPAAKPTVHKEPPALAVCGLVADFDPMGEEETTDFGPLVLDSDS 125
++ ++ G + + DA AK T +P + + ++ + E ET P + ++S
Sbjct: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTSES---SEEEEEAEAETAKATPRLASTNS 110
Query: 126 DDSVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTAL 185
+ D+ +++E KA++ AG P PA G L
Sbjct: 111 S-VLGADLPSSMKEKAKAET------------------EKAGKTGNSMPHPATGKTVANL 151
Query: 186 CPPKLVPGSGGGPGSQ---VGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQHET 242
K P P + V ++++GS ++ + +A+ ET
Sbjct: 152 LSGKS-PRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDET 210
Query: 243 QKCDGSVEKKPDTNENSAK-SLLKSHQEPPTKVVHRQGLLG--VQKEFAFRKPPRLAKMN 299
VE KP K S + + + P K G +G + PP
Sbjct: 211 D-----VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKK 265
Query: 300 VQPRSLRSKVTTTQENEGSTKPATPCRPSE--------AAQNKGGIKRSASAARRGKRVM 351
+ S S+ + E E + + SE +A KG + A+ A GK
Sbjct: 266 PEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGA 325
Query: 352 SAAQA--------SEASDSSSDDGIEEA------IQLYQLQKTRKEADGDLPQRVQLREE 397
A+Q SE+S S D EE +Q KT + P + R+
Sbjct: 326 VASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKG 385
Query: 398 RAPDPPAHSTSSATKSALPETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAPP 457
AP PP + + K+ + + S + ++D E +AP
Sbjct: 386 AAPAPPGKTGPAVAKAQAGKREEDSQSSSE--------------ESD------SEEEAPA 425
Query: 458 PASPASRSEFVERSSCRADTSAELMCAEAILDISKTILPAPVEGSDGSLSASPLFYSPNV 517
A P+ ++ V +S A S K PAP + G +A
Sbjct: 426 QAKPSGKAPQVRAASAPAKESPR-----------KGAAPAPPRKT-GPAAAQVQVGKQEE 473
Query: 518 PSRSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGG 577
SRS + S D + AL A + + + PQ + G
Sbjct: 474 DSRSSSEESDSDRE-----------ALAAMNAAQVKPLGKSPQVKPASTMGMG------- 515
Query: 578 HKTPLSKTPDPLLGCKRKRRGGGHVRPSTPK----KMQEVVKDGSQDA-DHSQGRAEPGH 632
PL K P+ G V P+TP K +E + S+++ D S G
Sbjct: 516 ---PLGKGAGPV--------PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAV 564
Query: 633 ERRDLPIQGKASEALGGEGTARGPGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDED 692
G +A A+GP + + + +D ESSE+ S S DS+E
Sbjct: 565 APAQEKSLGNILQAKPTSSPAKGPPQ-KAGPVAVQVKAEKPMDNSESSEESSDSADSEE- 622
Query: 693 LDTAIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKS 752
A ++K LK AC KK + + + PV
Sbjct: 623 -APAAMTAAQAKPALK---IPQTKACPKKTNTTASA----------------KVAPVRVG 662
Query: 753 CLSKSKRDSGEGPGKKPPSVFGST----AERMRQEGAASQDAALAFRVRRPASASASEGN 808
+ K + P P+V G T + E + S++ V + S +G
Sbjct: 663 TQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGL 722
Query: 809 PFPRES--------QGPAP-SPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQ 859
S QG AP PG + V + + E + ++ + + S ++V+
Sbjct: 723 QVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVK 782
Query: 860 AEGPTALGTGGPARPEVLCRKEPAPPPG-VCTRSQRA--RGVPHLAEGLRGTESAG--AQ 914
PA K PG V T + +A R + +R +++ A+
Sbjct: 783 TSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLAR 842
Query: 915 GTAGLFSQGGKGLPAAPARGDPVPPRSTS-------------GGVSAKGLSVSRRNVYVH 961
G A + S G AA A+ P +S V G + R
Sbjct: 843 GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP 902
Query: 962 KDQSPR-GAEPAAKSAFGQLPSCATAGTE 989
+SPR GA P G PS A AG +
Sbjct: 903 AKESPRKGAAPTPPGKTG--PSAAQAGKQ 929
Score = 33.9 bits (76), Expect = 0.96
Identities = 59/261 (22%), Positives = 90/261 (34%), Gaps = 34/261 (13%)
Query: 764 GPGKKPPSVFGSTAERMRQEGAASQDAALAFRVR--RPASASASEGNPFPRESQGPAPSP 821
G KP V A+ ++ ++S D +PA AS + ++ AP+P
Sbjct: 183 GAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAP 242
Query: 822 GSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQAEGPTALGTGGPARPEVL-CRK 880
G + D + V + K E+++ S SE + E P + A ++L R
Sbjct: 243 GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRA 302
Query: 881 EPAP------------PPGV--CTRSQRARGVPHLAEGLRGTESAGAQ------------ 914
AP PPG SQ G P ES+ ++
Sbjct: 303 ASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQA 362
Query: 915 GTAGLFSQ-GGKGLPA--APARG-DPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRGAE 970
+G SQ G PA +P +G P PP T V+ + ++S E
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 422
Query: 971 -PAAKSAFGQLPSCATAGTEA 990
PA G+ P A A
Sbjct: 423 APAQAKPSGKAPQVRAASAPA 443
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 55.8 bits (133), Expect = 2e-07
Identities = 145/702 (20%), Positives = 250/702 (35%), Gaps = 126/702 (17%)
Query: 173 KPEPAHGSAPTALCPPKLVPGSGGGPGSQVGSSKDQGSASPVSVSSDDSFEQSIRAE--- 229
+PE + T PP+ G+G P +K+Q SA P S ++ E ++E
Sbjct: 1195 RPESSLVFKDTLRTPPRERSGAGSSP-----ETKEQNSALPTSSQDEELMEVVEKSEEPA 1249
Query: 230 ---IEQFLNEKRQHETQKCDGS--VEKKP------DTNENSAK-------SLLKSHQEPP 271
+ +E ++ T + S VE++P D +++ A S+ S P
Sbjct: 1250 GQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPH 1309
Query: 272 TKVVHRQ--------------------GLLGVQKEFAFRKP-------PRLAKMNVQPRS 304
H++ G LG + F P L ++ P S
Sbjct: 1310 FSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDP-S 1368
Query: 305 LRSKVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRGKRVMSAAQASEASDSSS 364
L K +T+ + S+ +P A K G+ + S + + + E S S+S
Sbjct: 1369 LDMKEQSTRSSGHSSSELSP-----DAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSAS 1423
Query: 365 DDGIEEAIQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHSTSSATKSALPETHRKTPS 424
+++ + +++R + L + + P HS S ++ P
Sbjct: 1424 SPEMKDGLPRTPSRRSRSGSSPGL-------RDGSGTPSRHSLSGSS-----------PG 1465
Query: 425 KKKLVATKTMDPGPGGLDTDHAPKLLKETKAPPPASPASRSEFVERSSCRADTSAELMCA 484
K + +T G D+ PK L +T P SP+S E ++ E +
Sbjct: 1466 MKDI--PRTPSRGRSECDSSPEPKALPQTPRPRSRSPSS----PELNNKCLTPQRERSGS 1519
Query: 485 EAILDISKTILPAPVEGSDGSLSASPLFYSPNVPSRSDGDSSSVDSDDSIEQEIRTFLAL 544
E+ +D KT+ P+ S S+ L PS S + S DS + + RT L
Sbjct: 1520 ESSVD-QKTVARTPLGQRSRSGSSQELDVK---PSASPQERSESDSSPDSKAKTRTPLRQ 1575
Query: 545 KAQSGS------------LLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGC 592
+++SGS +R S P+ P P +Q+G +P K P P
Sbjct: 1576 RSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAP--RAQSGSDSSPEPKAPAPRALP 1633
Query: 593 KRKRRGGGHVRPSTPKKMQEVVKDGSQDADHSQGRAEPGHERRDLPIQGKASEALGGEGT 652
+R R G + K + +GS + S P H + + + + +
Sbjct: 1634 RRSRSG-------SSSKGRGPSPEGSSSTESS-----PEHPPKSRTARRGSRSSPEPKTK 1681
Query: 653 ARGPGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCR 712
+R P R S+ + RL + S S +T + R +R
Sbjct: 1682 SRTPPRRRSSRSSPELTRKARLSRRSRSASSSP--------ETRSRTPPRHRRSPSVSSP 1733
Query: 713 EPRAACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEGPGKKPPSV 772
EP R R +A + + R + P L+ S+S+R+ ++ S
Sbjct: 1734 EPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPK-PRGLQRSRSRSRREKTRTTRRRDRSG 1792
Query: 773 FGSTAERMRQEGAASQDAALAFRVRRPASASASEGNPFPRES 814
+ R RQ S+ + R RR S S +P +ES
Sbjct: 1793 SSQSTSRRRQR---SRSRSRVTRRRRGGSGYHSR-SPARQES 1830
Score = 53.1 bits (126), Expect = 2e-06
Identities = 138/672 (20%), Positives = 234/672 (34%), Gaps = 78/672 (11%)
Query: 292 PPRLAKMNVQPRSLRSKVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRGKRVM 351
P R A+ QP K + S++ TP + + + G +RS S++ R +R
Sbjct: 153 PQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRG-RRSESSSPRRERKK 211
Query: 352 SAAQASEASDSSSDDGIEEA----IQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHST 407
S+ + S+S S + + K RK + P R R+ + S+
Sbjct: 212 SSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASS 271
Query: 408 S----SATKSALPETH-------RKTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAP 456
S S ++SA +TH +P+ + PG T TK P
Sbjct: 272 SDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQP 331
Query: 457 PPASPASRSEFVERSSCRADTSAELMCAEAILDISKTILPAPVEGSDGSLSASPLFYSP- 515
+ E+S+ R S E +L GS L+ +PL P
Sbjct: 332 SSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPV 391
Query: 516 NVPSRSD--GDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNS 573
N PS + D S S + + Q + + + + ++R S + P PG +
Sbjct: 392 NPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHR 451
Query: 574 QTGGHKTPL-------------SKTPDPLLGCKRK----RRG---------GGHVRPSTP 607
+ T S TP +G R +RG GH R +P
Sbjct: 452 EISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSP 511
Query: 608 --KKMQEVVKDGSQDADHSQGRA----EPGHER-RDLPIQGKASEALGGEGTARGPGDTR 660
++ + + G + +GR+ PG R R+ +G++ A G +R P
Sbjct: 512 QWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRG 571
Query: 661 MSQGQGKTDEAR---RLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPRAA 717
S+ + R R + S ++ + A + RS+ ++R R
Sbjct: 572 RSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPV 631
Query: 718 CRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKSCLSKSK---RDSGEGPGKKPPSVFG 774
R+ S A+ + R + R + S+S+ R SG + P
Sbjct: 632 RRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGR 691
Query: 775 STAERMRQEGAASQDAALAFR------VRRPASASASEGNPFPRESQGPAPSPGSLSDDS 828
S + R+ + S+ R RR S S+SE R SQ + S S
Sbjct: 692 SRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKK 751
Query: 829 SSVDSNDSIELEIRKFLAE---KAKESVSSS----EVQAEGPTALGTGGPARPEVLCRKE 881
S + S S L + A+ + S+S S + +++ P G ++P+ R
Sbjct: 752 SRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTP 811
Query: 882 P-------APPP 886
P +PPP
Sbjct: 812 PRRSRSSSSPPP 823
Score = 41.6 bits (96), Expect = 0.005
Identities = 194/1011 (19%), Positives = 330/1011 (32%), Gaps = 129/1011 (12%)
Query: 101 LVADFDPMGEEETTDFGPLVLDSDSDDSVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGAA 160
L D +P G+EET P V ++ ++ E E L+A G + G+ +
Sbjct: 99 LEKDVNPGGKEETPGQRPAVTETHQL----AELNEKKNERLRAAFGISDSYVDGS---SF 151
Query: 161 QPSRAAGGGSRCKPEPAHGSAPTALCPPKLVPGSGGGPGSQVGSSKDQG----SASPVSV 216
P R A + PEP P +L S + KD+G S+SP
Sbjct: 152 DPQRRAREAKQPAPEPPK---PYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRE 208
Query: 217 SSDDSFEQSIRAEIEQFLNEKRQHETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVVH 276
S ++ R+E E ++KR+H + + + K + + K + P ++ H
Sbjct: 209 RKKSSKKKKHRSESE---SKKRKHRSP----TPKSKRKSKDKKRKRSRSTTPAPKSRRAH 261
Query: 277 RQGLLGVQKEFAFRKPPRLAKMNVQPRSLRSKVTTTQENEGSTKPATPCR-PSEAAQNKG 335
R + A ++ RS +K TT S PA+ R +A ++
Sbjct: 262 RS----TSADSASSSDTSRSRS----RSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEP 313
Query: 336 GIKRSASAARRGKRVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQRVQLR 395
G + S R + Q S + D E++ R + P L
Sbjct: 314 G---TTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLL 370
Query: 396 EER--------APDPPAHSTSSATKSALPETHRKTP-SKKKLVATKTMDPGPGGLDTDHA 446
ER A P + + A P R P S +KL + + + P
Sbjct: 371 AERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKV 430
Query: 447 PKLLKETKAPPPASPASRSEFVERSSCRADTSAELMCAEAILDISKTILPAPVEGSDGSL 506
+ + P +PA S R + TS A D S + P+ G S
Sbjct: 431 SRHASSSPESPKPAPAPGSH---REISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSP 487
Query: 507 SASPLFYSPNVPSRSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPL 566
+ + S + G S S + + + +S S RG S ++ Q P
Sbjct: 488 ATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRW----GRSRSPQRRGRS--RSPQRPG 541
Query: 567 LPPGLNSQTGGHKTPL------SKTPDPLLGCKRKRRGG--GHVRPSTPKKMQEVVKDGS 618
N+Q G S++P G R R G R TP + + + +
Sbjct: 542 WSRSRNTQRRGRSRSARRGRSHSRSP-ATRGRSRSRTPARRGRSRSRTPARRRSRSRTPT 600
Query: 619 QDADHSQGRAEPGHERRDLPIQGKASEALGGEGTARGPGDTRMSQGQGKTDEARRLDEKE 678
+ S+ A G R P + ++ +R R S ARR +
Sbjct: 601 RRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRS 660
Query: 679 SSEDKSSSLDSDEDLDTAIKDLLRSK-RKLKKRCREPR---AACRKKVRFSTAQTHFLEQ 734
+ + S + + R+ R+ + R R PR + R VR + + ++
Sbjct: 661 RTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQR 720
Query: 735 LG--------------GLRRDWKDRGPPVLKSCLSKSKRDSGEGPGKKP----------- 769
G RR + P + KS +S + S P K
Sbjct: 721 RGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLS 780
Query: 770 -----PSVFGSTAERMRQEGAASQDAALAFRVRRPASASA---------------SEGNP 809
P T R + G++ A RR S+S+ S +P
Sbjct: 781 GSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSP 840
Query: 810 FPRESQGPAPSPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQAEGPTALGTG 869
P+ G P GS+ +S +N+ R+ ES E+++ P+
Sbjct: 841 HPKVKSGTPPRQGSI----TSPQANEQSVTPQRR----SCFESSPDPELKSRTPSRHSCS 892
Query: 870 GPARPEVLCRKEPAPPPGVCTRSQ---RARGVPHLAEGLRGTESAGAQGTAGLFSQGGKG 926
G + P V P P + Q +A P + + ++ T+ + +
Sbjct: 893 GSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRS 952
Query: 927 L-PAAPARGDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRGAEPAAKSAFGQLPSCAT 985
+ P + +P S SG S + V + PR + + S + ++ +
Sbjct: 953 VSPCSNVESRLLPRYSHSGS--------SSPDTKVKPETPPRQSHSGSISPYPKVKAQTP 1004
Query: 986 AGTEAGGARGTFHMGCGSPSFLTPSPGAERDAGAQADRTPPWSDFAHQSRL 1036
G G++ S + PG+ TPP + S L
Sbjct: 1005 PGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSL 1055
Score = 39.7 bits (91), Expect = 0.018
Identities = 80/393 (20%), Positives = 142/393 (36%), Gaps = 53/393 (13%)
Query: 123 SDSDDSVDRDIEEAIQEYLKAKSGAAQ-----PGAGGAQPGAAQPSRAAGGGSRC--KPE 175
S S+ SVD+ +++SG++Q P A + + S + +R +
Sbjct: 1517 SGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQR 1576
Query: 176 PAHGSAPTALCPPKLVPGSGGGPGSQVGSS---KDQGSASPVSVSSDDSFEQSIRAEIEQ 232
GS+P +L P S+ GSS KD+ A+P + S DS + +A +
Sbjct: 1577 SRSGSSPEVDSKSRLSPRR-----SRSGSSPEVKDKPRAAPRAQSGSDSSPEP-KAPAPR 1630
Query: 233 FLNEKRQHETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGV-QKEFAFRK 291
L + + GS K + + S S + PP R+G + + R
Sbjct: 1631 ALPRRSR------SGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRT 1684
Query: 292 PPRLAKMNVQPRSLRSKVTTTQENEGSTKPATPCR-------------PSEAAQNKGGIK 338
PPR P R + + S+ P T R P A +++ +
Sbjct: 1685 PPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRR 1744
Query: 339 RSASAARRGKRVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQRVQLREER 398
R ++++ R K + S S G++ + + +KTR D Q R
Sbjct: 1745 RRSASSPRTKTTSRRGR----SPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRR 1800
Query: 399 APDPPAHSTSSATKSALPETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAPPP 458
+ S + + H ++P++++ T + + K + +P P
Sbjct: 1801 RQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAP 1860
Query: 459 -------ASPA------SRSEFVERSSCRADTS 478
ASPA SR+ + R R+ TS
Sbjct: 1861 WKRSRSRASPATHRRSRSRTPLISRRRSRSRTS 1893
Score = 36.2 bits (82), Expect = 0.19
Identities = 40/166 (24%), Positives = 62/166 (37%), Gaps = 19/166 (11%)
Query: 758 KRDSGEGPGKKPPSVFGSTAERMRQEGAASQDAALAFRVRRPASASASEGNPFP------ 811
+ S S S++ G++S D+ + +P A +P P
Sbjct: 2531 RSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAV 2590
Query: 812 RESQGPAPSPG-------SLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQAEGPT 864
RE + P P+P S S SSS S+ S + + S SSS + P+
Sbjct: 2591 REGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPS 2650
Query: 865 ALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLRGTES 910
G A P+ K+ PPPG +R+R + LR + S
Sbjct: 2651 PAKPGPQALPKPASPKK--PPPG----ERRSRSPRKPIDSLRDSRS 2690
Score = 32.0 bits (71), Expect = 3.7
Identities = 84/424 (19%), Positives = 135/424 (31%), Gaps = 56/424 (13%)
Query: 292 PPRLAKMNVQPRSLRSKVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRGKRVM 351
PP A R+ ++ + S P + + S ++AR +
Sbjct: 2317 PPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALS 2376
Query: 352 SAAQASEASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHSTSSAT 411
A S S+ + + L + R P + ++ ERAP P + + +
Sbjct: 2377 GANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPS 2436
Query: 412 KSALPETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAPPPASPASRSEFVERS 471
+S LP + S P P +D + L+ +T + S +
Sbjct: 2437 QSLLPPAQDQPRS-----------PVPSAF-SDQSRCLIAQTTPVAGSQSLSSGAVATTT 2484
Query: 472 SCRADTSAELMCAEAILDISKTILPAP-VEGSD-GSLSASPLFYSPNV-----PSRSDGD 524
S D + L +PAP V SD G AS P+ P++
Sbjct: 2485 SSAGDHNGMLS------------VPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRS 2532
Query: 525 SSSVDSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPL-- 582
SSS S S + + + SGS + E Q + + S T K +
Sbjct: 2533 SSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVRE 2592
Query: 583 SKTPDPLLGCKRKRRGGGHVRPSTPKKMQEVVKDGSQDADHSQGR--------------- 627
+ P+P KRKRR S+ S + S
Sbjct: 2593 GRPPEP-TPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSP 2651
Query: 628 AEPGHERRDLPIQGKASEALGGEGTARGPGDTRMSQGQGKT-----DEARRLDEKESSED 682
A+PG + LP + GE +R P S ++ E RR + S D
Sbjct: 2652 AKPGPQA--LPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRD 2709
Query: 683 KSSS 686
+ SS
Sbjct: 2710 QQSS 2713
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 55.1 bits (131), Expect = 4e-07
Identities = 116/594 (19%), Positives = 193/594 (32%), Gaps = 61/594 (10%)
Query: 251 KKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRLAKMNVQPRSLRSKVT 310
K+P +NS K K P ++ + + + +P R + + RS +
Sbjct: 257 KEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRR--RHRSRSRSYSPRRR 314
Query: 311 TTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRGKRVMSAAQASEASDSSSDDGIEE 370
+ S + TP R +RS S RR +R ++ S +S SSS
Sbjct: 315 PSPRRRPSPRRRTPPRRMPPPPRH---RRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPP 371
Query: 371 AIQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHSTSSATKSALPETHRKTPSKKKLVA 430
+ ++ P R P PPA S P+ +T + V+
Sbjct: 372 KKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVS 431
Query: 431 TKTMDPG-PGGLDTDHAPKLLKETKAPPPASPASRSEFVERSSCRADTSAELMCAEAILD 489
PG G T H K T+ SPA + VE S D ++ A+++
Sbjct: 432 -----PGRTSGKVTKH-----KGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQ 481
Query: 490 ISKTILPAPVEGSDGSLSASPLFYSPNVPSRSDGDSSSVDSDDSIEQEIRTFLALKAQSG 549
+ + N S SD SSS D+ ++ ++G
Sbjct: 482 RRQ-------------------YRRQNQQSSSDSGSSSSSEDERPKRS-------HVKNG 515
Query: 550 SLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGGHVRPSTPKK 609
+ R P + P + + S +P P +RR P ++
Sbjct: 516 EVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPT-----RRRRSPSPAPPPRRR 570
Query: 610 MQEVVKDGSQDADHSQGRAEPGHERRDLPIQGKASEALGGEGTARGPGDTRMSQGQGKTD 669
+ R P R PIQ + S + + P +
Sbjct: 571 RTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPP 630
Query: 670 EARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQT 729
RR+ + +SS + + K R + RE R+ K R S +
Sbjct: 631 PKRRVSHSPPPKQRSSPVTKRRSPSLSSKH--RKGSSPSRSTREARSPQPNK-RHSPSPR 687
Query: 730 HFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEGPGKKPPSVFGSTAERMRQEGAASQD 789
Q PPV + S +R P +P T E + + AAS
Sbjct: 688 PRAPQTSS-------SPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPS 740
Query: 790 AALAFRVRRPASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEIRK 843
VRR +S+ + G+P P + PAP P + S S + + ++ ++ K
Sbjct: 741 PQ---SVRRVSSSRSVSGSPEPAAKKPPAP-PSPVQSQSPSTNWSPAVPVKKAK 790
Score = 45.8 bits (107), Expect = 2e-04
Identities = 69/327 (21%), Positives = 119/327 (36%), Gaps = 42/327 (12%)
Query: 142 KAKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTALCPPKLVPGSGGGPGSQ 201
K++S +P SR+ R +P P +P PP+ +P S+
Sbjct: 283 KSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSR 342
Query: 202 VGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQHETQKCDGSVEKKPDTNENSAK 261
+ + S++ +S SS S R+ + K S +K SA
Sbjct: 343 SPVRRRRRSSASLSGSSSSSSSSRSRSP---------PKKPPKRTSSPPRKTRRLSPSAS 393
Query: 262 SLLKSHQ-----EPPTKVVHRQGLLGVQKEFAFRKPPRLAKMNVQPRSLRSKVTTTQENE 316
+ H+ PP K H Q+ RK ++++V P KVT + E
Sbjct: 394 PPRRRHRPSPPATPPPKTRHSP---TPQQSNRTRK----SRVSVSPGRTSGKVTKHKGTE 446
Query: 317 GSTKPATPCRP-----SEAAQNKGGIKRSASAARRGKRVMSAAQASEASDSSSDDGIEEA 371
P+ +P SE+ ++KGG +A + ++ ++ Q S +SDS S E+
Sbjct: 447 KRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQS-SSDSGSSSSSED- 504
Query: 372 IQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHSTSSATKSALPETHRKTPSKKKLVAT 431
+ K +G++ +R + R+ P T R++PS
Sbjct: 505 ----ERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPR--GRRRRSPSPPPTRRR 558
Query: 432 KTMDPGPGGLDTDHAPKLLKETKAPPP 458
++ P P P + T PPP
Sbjct: 559 RSPSPAP--------PPRRRRTPTPPP 577
Score = 32.7 bits (73), Expect = 2.1
Identities = 110/522 (21%), Positives = 168/522 (32%), Gaps = 72/522 (13%)
Query: 403 PAHSTSSATKSALPETHRKTPS--------KKKLV--ATKTMD----PGPGGLDTDHAP- 447
P H T S + S PE KTP K+ V AT T D P P + P
Sbjct: 201 PRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPS 260
Query: 448 --KLLKETKAPPPASPASRSEFVERSSCRADTSAELMCAEAILDISKTILPAPVEGSDGS 505
K K+ K P SRS RS R+ + + S++ +P
Sbjct: 261 PEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSY--SPRRRPSPR 318
Query: 506 LSASPLFYSPNVPSRSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGP 565
SP +P P R S + + R+ +L S S S ++ P
Sbjct: 319 RRPSPRRRTP--PRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSS-----SSSSRSRSPP 371
Query: 566 LLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGGHVRPSTPKKMQEVVKDGSQDADHSQ 625
PP S LS + P R+R PK S S+
Sbjct: 372 KKPPKRTSSPPRKTRRLSPSASP----PRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSR 427
Query: 626 GRAEPGHERRDLPIQGKASEALGGEGTARGPGDTRMSQGQ----GKTDEA---------R 672
PG + + K +E A P +S+ + GK A R
Sbjct: 428 VSVSPGRTSGKV-TKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYR 486
Query: 673 RLDEKESSEDKSSSLDSDE-DLDTAIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQTHF 731
R +++ SS+ SSS DE + +K+ +R+ R + RK+ + ++ +
Sbjct: 487 RQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPR--- 543
Query: 732 LEQLGGLRRDWKDRGPPVLKSCLSKS-------KRDSGEGPGKKPPSVFGSTAERMRQEG 784
G RR + PP + S S +R P ++ PS R
Sbjct: 544 -----GRRR--RSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPS--PPPRRRSPSPR 594
Query: 785 AASQDAALAFRVRRPASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEIRKF 844
S + P + P P+ P+P P S S
Sbjct: 595 RYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSP------- 647
Query: 845 LAEKAKESVSSSEVQAEGPTALGTGGPARPEVLCRKEPAPPP 886
+ ++ S+SS + P+ T P+ R P+P P
Sbjct: 648 VTKRRSPSLSSKHRKGSSPSR-STREARSPQPNKRHSPSPRP 688
Score = 30.8 bits (68), Expect = 8.1
Identities = 61/277 (22%), Positives = 97/277 (35%), Gaps = 30/277 (10%)
Query: 674 LDEKESSEDKSSSLDS-DEDLDTAIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQTHFL 732
+ +++ ++K +S+ DED D K+ S R+ ++R R PR R+K R + +
Sbjct: 131 IKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPR---RRKSRSPSPR---- 183
Query: 733 EQLGGLRRDWK---DRGPPVLKSCLSKSKRDSGEGPGKKPPSVFGSTAERMRQEGAASQD 789
+ +RR+ K R P S S + + P E QE ++ D
Sbjct: 184 RRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSD 243
Query: 790 AALAFR---VRRPASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEIRKFLA 846
+ + P S + + +E + P S S S S R
Sbjct: 244 ILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPR---- 299
Query: 847 EKAKESVSSSEVQAEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLR 906
+ S S S P+ P R R+ P PP +RS R R
Sbjct: 300 -RRHRSRSRSYSPRRRPSPRRRPSPRR-RTPPRRMPPPPRHRRSRSPVRR---------R 348
Query: 907 GTESAGAQGTAGLFSQG-GKGLPAAPARGDPVPPRST 942
SA G++ S + P P + PPR T
Sbjct: 349 RRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKT 385
>gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens]
Length = 2303
Score = 53.5 bits (127), Expect = 1e-06
Identities = 169/759 (22%), Positives = 260/759 (34%), Gaps = 117/759 (15%)
Query: 316 EGSTKPATPCRPSEAAQNKGGIKRSASAARRGKRVMSAAQASEASDS----SSDDGIEEA 371
EG + +PCR E GG + + S A R + AA AS ++DS S+ DG
Sbjct: 886 EGRAQSCSPCRGPE-----GGRREAGSRAHPLLR-LKAAHASLSNDSLNSGSASDGYCPR 939
Query: 372 IQLYQLQKTRKEADGDLPQRVQLREERAP--------DPPAHSTSSATKSA----LPETH 419
+ + + P+ Q R R +PPA +SA L T+
Sbjct: 940 EHMLPCPLAALASRREDPRCGQPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSPTY 999
Query: 420 RKTP---SKKKLVATKTMDPG--PGG-----LDTDHAPKLLKETKAPPPASPASRSEFVE 469
+ P + A PG PG L DH K+ E A P S AS++ ++
Sbjct: 1000 QHVPLLEGASRAGAEPLAGPGISPGARKQAWLPADHLSKV-PEKLAAAPLSVASKA--LQ 1056
Query: 470 RSSCRADTSAELMCAEAILDISKTILPAPVEGSDGSLSASPLFYSPNVPSRSDGDSSSVD 529
+ + + + C+ ++ +S P P EG D D DSS
Sbjct: 1057 KLAAQEGPLSLSRCS-SLSSLSSAGRPGPSEGGD----------------LDDSDSSLEG 1099
Query: 530 SDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPL 589
+++ E +A + L P+ +G L + + + + +TP L
Sbjct: 1100 LEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVEDATPSSSSENYVQETPLVL 1159
Query: 590 LGCKRKRRGGGHVRPSTPKKMQEVVKDGSQDADHSQGRAEPGHERRDLPIQGKASEALGG 649
C G PS + G S P + +P + L
Sbjct: 1160 SRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSEL-PDSPGQTMPPSRSKTPPLAP 1218
Query: 650 EGTARGPGDTRMSQGQGKTDEARRLDEKESSED--KSSSLDSDEDLDTAIKDLLRSKRKL 707
+GP + Q ++ R LD + E S LD+ T K
Sbjct: 1219 --APQGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKP-------- 1268
Query: 708 KKRCREPRAACRKKVRFSTAQTHFLEQLGGLR---RDWKDRGPPVLKSCL---SKSKRDS 761
+ +C + H+++Q LR +RG + L +R+
Sbjct: 1269 -----DENFSCASSLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREE 1323
Query: 762 GEGP-GKKPPSVFGSTAERMRQEGAASQDAALAFRVRRPASASASEGNPFPRESQGPAPS 820
G P G +P E +R+ AA+ R+R+ ASA P P+
Sbjct: 1324 GPAPTGSRPRGAADQELELLRE----CLGAAVPARLRKVASALVPGRRALPVPVYMLVPA 1379
Query: 821 PGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQAEGPTALGTGGPARPEVLCRK 880
P +D S DS + + + S S+ +GP GGPA R+
Sbjct: 1380 PAPAQEDDSCTDSAEGTPVNF--------SSAASLSDETLQGPPRDQPGGPAG-----RQ 1426
Query: 881 EPAPPPGVCTRSQRARGVPHLA--EGLRGTESAGA-QGTAGLFSQGGKGLPAAPARGDPV 937
P P T +++A G H A G +S GA + AGL G+ P+APA D
Sbjct: 1427 RPTGRP---TSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRP-PSAPADKDGS 1482
Query: 938 PPRSTSGGVSAKGLSV---SRRNVYV----HKDQSPRGAEPA-AKSAFGQLPSCATAGTE 989
P T G + + L + + VY D+ P A P +P T
Sbjct: 1483 KPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERP 1542
Query: 990 AGGARGTFHMGCGSPSFLTPS--PGAERDAGAQADRTPP 1026
G +PS P+ P A AD TPP
Sbjct: 1543 QGRKEAP------APSKAAPAAPPPARTQPSLIADETPP 1575
Score = 33.1 bits (74), Expect = 1.6
Identities = 86/431 (19%), Positives = 143/431 (33%), Gaps = 36/431 (8%)
Query: 61 RGTSDERAAQRGHRAEGCHDARPAAKPTVHKEPPALAVCGLVADFDPMGEEETTDFGPLV 120
R TS A R +G +A +K PPA L+AD ET L
Sbjct: 1528 RRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIAD-------ETPPCYSLS 1580
Query: 121 LDSDSDDSVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGS 180
+ S + A+ + + PG GG + + P A RC
Sbjct: 1581 SSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRR 1640
Query: 181 APTALCPPKLVPGSGGGPGSQVGSSKDQG--SASPVSVSSDDSFE-QSIRAEIEQFLNEK 237
P + P + S+++G +A S DS E ++I+ +
Sbjct: 1641 RPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWL 1700
Query: 238 RQHETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRLAK 297
Q + S E + S S+ + Q P HR+G + + R+P +
Sbjct: 1701 HQAAAATREASSESDSILSFVSGLSVGSTLQPPK----HRKGRQAEGEMGSARRPEKRGA 1756
Query: 298 MNVQPRSLRSKVTTTQENEGS--TKPATPC-----------RPSEAAQNKGGIKRSASAA 344
+V+ ++ G+ T P P P+ AQ KG +
Sbjct: 1757 ASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKG----TPGPR 1812
Query: 345 RRGKRVMSAAQASEASDSS-SDDGIEEAIQLYQLQKTRKEADGDLPQRVQLREERAPDPP 403
++V A A+ + G + + L++ KT + A P R R P
Sbjct: 1813 ATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTP 1872
Query: 404 AHSTSSATKSALPETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAPPPASPAS 463
+ S+S + ++ P ++ P + A PGPG P K
Sbjct: 1873 SSSSSQTSPASQPLPRKRPPVTQAAGAL----PGPGASPVPKTPARTLLAKQHKTQRSPV 1928
Query: 464 RSEFVERSSCR 474
R F++R + R
Sbjct: 1929 RIPFMQRPARR 1939
>gi|33946327 nucleoporin 214kDa [Homo sapiens]
Length = 2090
Score = 52.0 bits (123), Expect = 3e-06
Identities = 97/437 (22%), Positives = 163/437 (37%), Gaps = 63/437 (14%)
Query: 152 AGGAQPGAAQPSR----AAGGGSRCKPEPAHGSAPTALCPPKLVPGSGGGPGSQVGSSKD 207
A GA P + S+ ++GGGS+ P++ + P + P + S PG SS
Sbjct: 1239 AQGATPSTKESSQPDAFSSGGGSK----PSYEAIPESSPPSGITSASNTTPGEPAASSSR 1294
Query: 208 QGSASPVSVSSDDSFEQSIRAEIEQFLNEKR-------QHETQKCDGSVEKKPDTNENSA 260
+ S ++S+ S ++ +++ + L + + + TN+ S+
Sbjct: 1295 PVAPSGTALSTTSSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASS 1354
Query: 261 KSLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRLAKMNVQPRSLRSKVTTTQENEGSTK 320
SL + PTK GV F F PP L K + +P S TT+ +T
Sbjct: 1355 TSLTSTQ---PTKTS------GVPSGFNFTAPPVLGK-HTEPPVTSSATTTSVAPPAATS 1404
Query: 321 PATPC----RPSEAAQNKGGIKRSASAARRGKRVMS--AAQASEASDSSSDDGIEEAIQL 374
++ P +A + G I ++ GK S + Q + S+ A L
Sbjct: 1405 TSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPL 1464
Query: 375 YQLQKTRKEADGDLPQRVQLREERAPDPP---AHSTSSATKSALPETHRKTPSKKKLVAT 431
T + G L L P P ST AT SALPE
Sbjct: 1465 PTSFPTL--SFGSL-----LSSATTPSLPMSAGRSTEEATSSALPE-------------- 1503
Query: 432 KTMDPGPGGLDTDHAPKLLKETKAPPPASPASRSEFVERSSCRA----DTSAELMCAEAI 487
PG + A L ++ A P +P S+ V++ A S + ++
Sbjct: 1504 ---KPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSL 1560
Query: 488 LDISKTILPAPVEGSDGSLSASPLFYSPNVPSRSDGDSSSVDSDDSIEQEIRTFLALKAQ 547
+ +S PA D A P S +VP ++ ++++ S + E + + +
Sbjct: 1561 VALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVETSS-TPIASS 1619
Query: 548 SGSLLARGESCPQAAQG 564
+ S++A G S AA G
Sbjct: 1620 TTSIVAPGPSAEAAAFG 1636
Score = 42.7 bits (99), Expect = 0.002
Identities = 93/362 (25%), Positives = 128/362 (35%), Gaps = 37/362 (10%)
Query: 799 PASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEV 858
P++ +A+ G S P S S + + +N + + A + S
Sbjct: 1628 PSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAASTAPSLFG 1687
Query: 859 QAEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGV-PHLAEGLRGTESAGAQGTA 917
Q G TA + A P+V +P G A GV G A A
Sbjct: 1688 QQTGSTA--STAAATPQVSSSGFSSPAFGTT-----APGVFGQTTFGQASVFGQSASSAA 1740
Query: 918 GLFSQGGKGLPAAPARGDPV--PPRSTSGGVSAKGLSVSRRNVYVHKDQSPR-GAEPAAK 974
+FS G + PA G P P STSG V S S + + SP G +
Sbjct: 1741 SVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQ 1800
Query: 975 S---AFGQLPSCATAGTEAGG-ARGTFHMGCGSPSFLTPSPGAERDAGAQADRTPPWSD- 1029
S AFGQ P G+ GG + T SF S + G+ +
Sbjct: 1801 SNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGI 1860
Query: 1030 -FAHQSRLPSPWVLRS--EGRDAVWRGGVGSERDKGSEGPARGLP-SLPLAGFSPLL--- 1082
F QS S V S GR + G+G K S+ A P S GF
Sbjct: 1861 VFGQQSSSSSGSVFGSGNTGRGGGFFSGLGG---KPSQDAANKNPFSSASGGFGSTATSN 1917
Query: 1083 STQLFHFGKGVSWGG---------RQAGLFSPHLG-LPLQGPSFSAFREAQA-GPSPVFG 1131
++ LF ++GG + G FS G + QG FS+ + G +PVFG
Sbjct: 1918 TSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFG 1977
Query: 1132 SP 1133
SP
Sbjct: 1978 SP 1979
Score = 37.0 bits (84), Expect = 0.11
Identities = 60/290 (20%), Positives = 101/290 (34%), Gaps = 47/290 (16%)
Query: 705 RKLKKRCREPRAACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEG 764
++LK P A V +STA+T P + + ++ ++ G
Sbjct: 1126 QELKNNPATPSTAMGSSVPYSTAKT-----------------PHPVLTPVAANQAKQGSL 1168
Query: 765 PGKKPPSVFGSTAERMRQEGAASQDAALAFRVRRPASASASEGNPFPRESQGPAPSPGSL 824
PS + ++ AS A + V SAS PF G + G +
Sbjct: 1169 INSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSGTGFNFGII 1228
Query: 825 SDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQAEGPTALGTGGPARPEVLCRKEPAP 884
+ SS + A + + S ++ P A +GG ++P E +P
Sbjct: 1229 TPTPSSNFT---------------AAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSP 1273
Query: 885 PPGVCTRSQRARGVPHLAEGLRGTESAGAQGTAGLFSQGGKGLPAAPAR-GDPVPPRSTS 943
P G+ + S G P + GTA S L P++ G+ + P S +
Sbjct: 1274 PSGITSASNTTPGEP----AASSSRPVAPSGTA--LSTTSSKLETPPSKLGELLFPSSLA 1327
Query: 944 GGV--SAKGLSVSRRNVYVHKDQSPRGAEPAAKSAFGQLPSCATAGTEAG 991
G S GL V + D S + A+ ++ T+G +G
Sbjct: 1328 GETLGSFSGLRVGQ------ADDSTKPTNKASSTSLTSTQPTKTSGVPSG 1371
>gi|239758013 PREDICTED: hypothetical protein [Homo sapiens]
Length = 819
Score = 50.4 bits (119), Expect = 1e-05
Identities = 122/548 (22%), Positives = 191/548 (34%), Gaps = 75/548 (13%)
Query: 574 QTGGHKTPLSKTPDPLLGCKRKRRGGGHVRPSTPKKMQEVVKDGSQDADHSQG------- 626
+T G + + P P G + RRGGG ++ Q+ G S+G
Sbjct: 216 KTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLR 275
Query: 627 -----RAEPGHERRDLPIQGKASEALGGEGTARGP---GDTRMSQGQGKTDEARRLDEKE 678
A G +RR G+ A G G RGP G G+G + RR +K
Sbjct: 276 RQGQNAALAGAKRRGAATAGEKPAAKGRGG--RGPKSLGGQNPRWGRG-GKKPRRRGQKA 332
Query: 679 SSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQTHFLEQLGGL 738
+ + + A ++S++K ++R ++PR R+K + A++ GL
Sbjct: 333 TKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPR---RQKASAAGAKSRGGGDKKGL 389
Query: 739 RRDWKDRGPPVLKSCLSKSKRDSGEGPGKKP-------PSVFGSTAERMR----QEGAAS 787
R+ K RG K +R + + P KP P G A + R + G
Sbjct: 390 -REAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGK 448
Query: 788 QDAALAFRVRRPASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEIRKFLAE 847
+ + R+ A+ + +E ++ + A + G+ S + S+ L R AE
Sbjct: 449 KPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKS-RGGGLKSHSGKNLWRRGQKAE 507
Query: 848 KAKESVSSSEVQAEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLRG 907
A E + A G + G P R + + G +R QR + V A G
Sbjct: 508 AAGEKAT-----AAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSR-QRQKAVAAGATSHGG 561
Query: 908 TESAGAQGTAG-LFSQGGKGLPAAPAR--GDPVP-----------PRSTSGGVSAKGLSV 953
+ ++G G Q G+ AA R GD P RS GG A
Sbjct: 562 GGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKA 621
Query: 954 SRRNVYVHKDQSPRGAEPAAKSAFGQLPSCATAGTEAGGARGTFHMGCGSPSFLTPSPGA 1013
+ K RG + AA + + G+ R GS S + G
Sbjct: 622 AGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQ 681
Query: 1014 ERDAGAQADR----------------TPPWSDFAHQSRLPSPWVLRSEGRDAVWRGGVGS 1057
E +A + R PW Q R P + +S G G G
Sbjct: 682 EAEARKKPRRRRAKSRGDGGQNAAVGINPW-----QRRGKKPRLGKSRGGGGAKSRGSGG 736
Query: 1058 ERDKGSEG 1065
+ +GS G
Sbjct: 737 AKSRGSGG 744
Score = 38.5 bits (88), Expect = 0.039
Identities = 86/399 (21%), Positives = 141/399 (35%), Gaps = 56/399 (14%)
Query: 569 PGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGGHVRPST--PKKMQEVVKDGSQD-ADHSQ 625
P + GG K P + P K R GG +P K Q+ + G++ D Q
Sbjct: 415 PAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQ 474
Query: 626 GRAEPG-------------HERRDLPIQGKASEALGGEGTARGPGDTRMSQGQGKTDEAR 672
GR + H ++L +G+ +EA G + TA G ++ +G+ R
Sbjct: 475 GRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAG------AKSRGRKQPRR 528
Query: 673 RLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQTHFL 732
+ ++ + S + K+ R K ++
Sbjct: 529 QKPAVAGAKSRVGGSKSRQRQKAVAAGATSHGGGGNKQSRG--GGGNKPRQWGQTAAAAK 586
Query: 733 EQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEGPGKKPPSVFGSTAERMRQEG--AASQDA 790
+ GG D+ P K+ +K SG+G K T + R++ +DA
Sbjct: 587 TRGGG------DKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDA 640
Query: 791 ALAFRVRRPASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEIRKFLAEKAK 850
A A + + S G PR Q PA + GS S +++V E E RK K +
Sbjct: 641 AAAEKAWATGATSRGSGGKQPRW-QKPAAA-GSESSAAAAVGQ----EAEARK----KPR 690
Query: 851 ESVSSSEVQAEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLRGTES 910
+ S A+G P G R ++RG RG+
Sbjct: 691 RRRAKSRGDGGQNAAVGIN------------PWQRRGKKPRLGKSRGGGGAKS--RGSGG 736
Query: 911 AGAQGTAGLFSQGGKGLPAAPARGDPVPPRSTSGGVSAK 949
A ++G+ G S+ GK A+ + G R GG ++
Sbjct: 737 AKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSR 775
Score = 37.4 bits (85), Expect = 0.087
Identities = 158/796 (19%), Positives = 261/796 (32%), Gaps = 126/796 (15%)
Query: 134 EEAIQEYLKAK-SGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTALCPPKLVP 192
+EA Q + KA +G A+ GG Q AA +++ GG R +A T P+
Sbjct: 83 KEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRA 142
Query: 193 GSGGGPGSQVGSSKDQGSASPVSVSSD--DSFEQSIRAEIEQFLNEKRQHETQKCDGSVE 250
GS+ + Q +A+ V S + +++ A + +K + K G +
Sbjct: 143 QKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRRGAKSRGDED 202
Query: 251 KKPDTNENSAK------SLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRLAKMNVQPRS 304
KK E ++ K H+ P + G + K P+ + Q +
Sbjct: 203 KKGRQREAKSRFGKTRGGRRKKHRRP------KPAAGGAKSRRGGGKKPQKQRRRGQKAA 256
Query: 305 LRSKVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAA-------------------- 344
K + G K R + A G +R A+ A
Sbjct: 257 TGGKSRVGKSRGGGDKKLR--RQGQNAALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQ 314
Query: 345 -----RRGK----RVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQRVQLR 395
R GK R A +A+ A G ++A + + ++ G P+R
Sbjct: 315 NPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRR---- 370
Query: 396 EERAPDPPAHSTSSATKSALPETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKA 455
++A A S K L E R+ +KK + +P A +K
Sbjct: 371 -QKASAAGAKSRGGGDKKGLREAKRRGDGRKK---PRWQNPRRRAQKAPAAKPRGGGSKK 426
Query: 456 PPPASPASRSEFVERSSCRADTSAELMCAEAILDISKTILPAPVEGSDGSLSASPLFYSP 515
P P + +S +A ++ + + G AS +
Sbjct: 427 PRRRGPKAAKSRGGKSRSGGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKAS----AA 482
Query: 516 NVPSRSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQT 575
SR G LK+ SG L R +AA G S+
Sbjct: 483 GTKSRGGG--------------------LKSHSGKNLWRRGQKAEAAGEKATAAGAKSR- 521
Query: 576 GGHKTPLSKTPDPLLGCKRKRRGGGHVRPSTPKKMQEVVKDGSQD---ADHSQGRAEPGH 632
G K P + P + + R GG S ++ Q+ V G+ + Q R G+
Sbjct: 522 -GRKQP--RRQKPAVAGAKSRVGG-----SKSRQRQKAVAAGATSHGGGGNKQSRGGGGN 573
Query: 633 ERRDLPIQGKASEALGGEGTARGPGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDED 692
+ R A++ GG + PG + + G K+ K++ K++ +
Sbjct: 574 KPRQWGQTAAAAKTRGGGD--KQPGWQKAAAGVTKSRSGD--GGKKAWRQKAAGTGA--- 626
Query: 693 LDTAIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKS 752
+S++K +R ++ AA K ++T T GG + W+ P S
Sbjct: 627 ---------KSRKKPWRRGQKDAAAAEK--AWATGATS--RGSGGKQPRWQK--PAAAGS 671
Query: 753 CLSKSKRDSGEGPGKKPPSVFGSTAERMRQEGAASQDAALAF-----RVRRPASASASEG 807
S + E +K P R + G Q+AA+ R ++P + G
Sbjct: 672 ESSAAAAVGQEAEARKKP-----RRRRAKSRGDGGQNAAVGINPWQRRGKKPRLGKSRGG 726
Query: 808 NPFPRESQGPAPSPGSLSDDSSSVDSNDSIELE----IRKFLAEKAKESVSSSEVQAEGP 863
G A S GS S S + + ++ AK V A G
Sbjct: 727 GGAKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQ 786
Query: 864 TALGTGGPARPEVLCR 879
A GG P V R
Sbjct: 787 KAAAAGGKKPPRVKSR 802
Score = 32.3 bits (72), Expect = 2.8
Identities = 49/218 (22%), Positives = 72/218 (33%), Gaps = 20/218 (9%)
Query: 764 GPGKKPPSVFGSTAERMRQEGAASQDAALAFRVRRPASASASEGNPFPRESQGPAPSPGS 823
GPG + T + E AA +A A V+ S R+
Sbjct: 17 GPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKK----LRRQKAAAGGKKAR 72
Query: 824 LSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQAEGPTALGTGGPARPEVLCRKEPA 883
L +V ++ + +K E+ E +A GG R R+
Sbjct: 73 LRGQKGAVAGKEARQ-HWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKP---RRRGQ 128
Query: 884 PPPGVCTRSQRARGVPHLAEGL--RGTESAGAQGTAGLFSQGGKGLPAAPARGDPVPPRS 941
++ R R A G RG + A AG+ SQGG+ A A
Sbjct: 129 KAAATGSKKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAA--------- 179
Query: 942 TSGGVSAKGLSVSRRNVYVHKDQSPRGAEPAAKSAFGQ 979
+G S G RR D+ +G + AKS FG+
Sbjct: 180 -AGAKSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGK 216
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 50.4 bits (119), Expect = 1e-05
Identities = 68/372 (18%), Positives = 129/372 (34%), Gaps = 15/372 (4%)
Query: 110 EEETTDFGPLVLDSDSDDSVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGAAQPSRAAGGG 169
E+ET +V + + V ++ E ++ K + G + G + A GG
Sbjct: 451 EKETV----IVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGG--------EEEEAEGGE 498
Query: 170 SRCKPEPAHGSAPTALCPPKLVPGSGGGPGSQVGSSKDQGSASPVSVSSDDSFEQSIRAE 229
K PA +A V P K++ SP V S + + + E
Sbjct: 499 EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAK-SPAEVKSPEKAKSPAKEE 557
Query: 230 IEQFLNEKRQHETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAF 289
+ K + + + K P+ ++ AK KS E + + + K A
Sbjct: 558 AKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAE 617
Query: 290 RKPP--RLAKMNVQPRSLRSKVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRG 347
K P AK + +S + T+E S + A EA + + A+
Sbjct: 618 AKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSP 677
Query: 348 KRVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHST 407
++ S +A S + ++E + + K+ + + P++ + + P +
Sbjct: 678 EKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAK 737
Query: 408 SSATKSALPETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAPPPASPASRSEF 467
S + A K+P K K + K+ + + +P KA P +S
Sbjct: 738 SPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPE 797
Query: 468 VERSSCRADTSA 479
+S + D A
Sbjct: 798 KAKSPLKEDAKA 809
Score = 45.1 bits (105), Expect = 4e-04
Identities = 119/646 (18%), Positives = 224/646 (34%), Gaps = 71/646 (10%)
Query: 203 GSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQHETQKCDGSVEKKPDTNENSAKS 262
G K ++ + V S++ + ++E E + E++ ETQ + E++ +
Sbjct: 425 GLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGK 484
Query: 263 LLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRLAKMNVQPRSLRSKVTTTQENEGSTKPA 322
+ +E + + +E A P + AK V+ + + E E + PA
Sbjct: 485 EEEGGEEEEAEGGEEETKSPPAEEAA--SPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPA 542
Query: 323 TPCRPSEAAQNKGGIKRSASAARRGKRVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRK 382
P +A K K A + K S A S + A ++ +
Sbjct: 543 EVKSPEKA---KSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPA-----KEEAKS 594
Query: 383 EADGDLPQRVQLREERAPDPPAHSTSSATKSALPETHRKTPSKKKLVATKTMDPGPGGLD 442
A+ P++ + + PA + S + A K+P K K TK P
Sbjct: 595 PAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKS-PTKEEAKSPEKAK 653
Query: 443 TDHAPKLLKETKAPPPASPASRSEFVERSSCRADTS----AELMCAEAILDISKTILPAP 498
+ + KA P ++S +S +A+ A+ E K P
Sbjct: 654 SPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVK 713
Query: 499 VEGSDGSLSASPLFYSPNVP--SRSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGE 556
E + SP+ P ++S + + + E L +K+ A+ E
Sbjct: 714 EEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE 773
Query: 557 S------CPQAAQGPLLPPGLNSQTGGHKTPL---SKTPDPLLGCKRKRRGGGHVRPSTP 607
+ P+ A+ P+ + + K+PL +K P+ + K + +
Sbjct: 774 ARSPADKFPEKAKSPVKEEVKSPEKA--KSPLKEDAKAPEKEIPKKEEVKSP----VKEE 827
Query: 608 KKMQEV-VKDGSQDADHSQGRAEPGHERRDLPIQGKASEALGGEGTARGPGDTRMSQGQG 666
+K QEV VK+ + A+ + A P E + K EA E + + +
Sbjct: 828 EKPQEVKVKEPPKKAEEEKAPATPKTEEKK---DSKKEEAPKKEAP-KPKVEEKKEPAVE 883
Query: 667 KTDEARRLDEKESSEDKSS--SLDSDEDLDTAIKDLLRSKRKLKKRCREPRAACRKKVRF 724
K E++ +KE +EDK + + + +K+ + K K + +EP A K
Sbjct: 884 KPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAK---- 939
Query: 725 STAQTHFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEGPGKKPPSVFGSTAERMRQEG 784
+ P K + K+D+ E KKP E+ + E
Sbjct: 940 -------------------EPSKPAEKKEAAPEKKDTKEEKAKKP-------EEKPKTEA 973
Query: 785 AASQDAALAFRVRRPASASASEGNPFPRESQGPAPSPGSLSDDSSS 830
A +D + P+ A + Q + P ++D ++
Sbjct: 974 KAKEDDKTL--SKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAA 1017
Score = 34.7 bits (78), Expect = 0.56
Identities = 81/432 (18%), Positives = 151/432 (34%), Gaps = 29/432 (6%)
Query: 122 DSDSDDSVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSA 181
++ S + ++E + +AKS + A+ + + +++ PE A
Sbjct: 597 EAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPE 656
Query: 182 PTALCPPKLV--PGSGGGPGSQVGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQ 239
P+ P + S + A + E++ E + ++
Sbjct: 657 KEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA 716
Query: 240 HETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVV--HRQGLLGVQKEFAFRKPPRLAK 297
+K V+++ T E AKS +K + P K + L V+ A A+
Sbjct: 717 KSPEKAKSPVKEEAKTPEK-AKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEAR 775
Query: 298 MNVQPRSLRSKVTTTQENEGSTKPATPCR-----PSEAAQNKGGIKRSASAARRGK--RV 350
++K +E + K +P + P + K +K + + +V
Sbjct: 776 SPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKV 835
Query: 351 MSAAQASEASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHSTSSA 410
+ +E + + EE + + +KEA +V+ ++E A + P S A
Sbjct: 836 KEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAP---KPKVEEKKEPAVEKPKESKVEA 892
Query: 411 TKSALPETHR-KTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAPPPASPASRSEFVE 469
K + + TP K+ + + T+ A K + KA P+ PA + E
Sbjct: 893 KKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAP 952
Query: 470 RSSCRADTSAELMCAEAILDISKTILPAPVEGSDGSLSASPLFYSPNVPSRSDGD-SSSV 528
+ DT E +A K A + D +LS P+ P + SSS
Sbjct: 953 E---KKDTKEE----KAKKPEEKPKTEAKAKEDDKTLSK-----EPSKPKAEKAEKSSST 1000
Query: 529 DSDDSIEQEIRT 540
D DS E T
Sbjct: 1001 DQKDSKPPEKAT 1012
>gi|153070260 myristoylated alanine-rich protein kinase C substrate
[Homo sapiens]
Length = 332
Score = 47.8 bits (112), Expect = 6e-05
Identities = 83/362 (22%), Positives = 125/362 (34%), Gaps = 86/362 (23%)
Query: 546 AQSGSLLARGESC---PQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLL---GCKRKRRGG 599
AQ A+GE+ P A P N Q GH ++ P G K + +
Sbjct: 3 AQFSKTAAKGEAAAERPGEAAVASSPSKANGQENGH-VKVNGDASPAAAESGAKEELQAN 61
Query: 600 GHVRPSTPKKMQEVVKDGSQDADHSQGRAEPGHERRDLPIQGKASEA--------LGGEG 651
G S P D + A G A P + P A EA EG
Sbjct: 62 G----SAP------AADKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAEG 111
Query: 652 TARGPGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRC 711
A PG ++G+ + + K +ED ++ S+E
Sbjct: 112 EAAEPGSPTAAEGEAASAASSTSSPK--AEDGATPSPSNET------------------- 150
Query: 712 REPRAACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEGPGKKPPS 771
P+ +KK RFS ++ L K+K+++GEG + P+
Sbjct: 151 --PK---KKKKRFSFKKSFKLSGFS-----------------FKKNKKEAGEGGEAEAPA 188
Query: 772 VFGSTAERMRQEGAASQDAALAFRVRRPA---SASASE-----GNPFPRESQGPAPSPGS 823
G E AA+ +A A + A A+A E G+P + Q A +P
Sbjct: 189 AEGGKDEAAGGAAAAAAEAGAASGEQAAAPGEEAAAGEEGAAGGDPQEAKPQEAAVAPEK 248
Query: 824 --LSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQAEGPTALGTGGPARPEVLCRKE 881
SD++ + + +E EK E +S E P+A G G P E +E
Sbjct: 249 PPASDETKAAEEPSKVE--------EKKAEEAGASAAACEAPSAAGPGAPPEQEAAPAEE 300
Query: 882 PA 883
PA
Sbjct: 301 PA 302
Score = 34.7 bits (78), Expect = 0.56
Identities = 62/317 (19%), Positives = 103/317 (32%), Gaps = 35/317 (11%)
Query: 158 GAAQPSRAAGGGSRCKPEPAHGSAPTALCPPKLVPGSGGGPGSQVGSSKDQGSASPVSVS 217
G A P+ A G + A+GSAP A GSG S + +A+P + +
Sbjct: 43 GDASPAAAESGAK--EELQANGSAPAADKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGA 100
Query: 218 SDDSFEQSIRAEIEQFLNEKRQHETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVVHR 277
S E E + + S P + + S S++ P K
Sbjct: 101 SPVEKEAPAEGEAAEPGSPTAAEGEAASAASSTSSPKAEDGATPS--PSNETPKKK---- 154
Query: 278 QGLLGVQKEFAFRKPPRLAKMNVQPRSLRSKVTTTQENEGSTKPATPCRPSEAAQN---- 333
+K F+F+K +L+ S + E + PA EAA
Sbjct: 155 ------KKRFSFKKSFKLSGF-----SFKKNKKEAGEGGEAEAPAAEGGKDEAAGGAAAA 203
Query: 334 --KGGIKRSASAARRGKRVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQR 391
+ G AA G+ + + + D E A+ + + + + P +
Sbjct: 204 AAEAGAASGEQAAAPGEEAAAGEEGAAGGDPQEAKPQEAAVAPEKPPASDETKAAEEPSK 263
Query: 392 VQLR--EERAPDPPAHSTSSATKSALPETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKL 449
V+ + EE A SA P P+++ A + AP
Sbjct: 264 VEEKKAEEAGASAAACEAPSAAGPGAPPEQEAAPAEEPAAAAAS--------SACAAPSQ 315
Query: 450 LKETKAPPPASPASRSE 466
+ + P A PA +E
Sbjct: 316 EAQPECSPEAPPAEAAE 332
Score = 32.3 bits (72), Expect = 2.8
Identities = 55/234 (23%), Positives = 81/234 (34%), Gaps = 27/234 (11%)
Query: 755 SKSKRDSGEGPGKKPPSVFGSTAERMRQ-EGAASQDAALAFRVRRPASASASEGNPFPRE 813
S S + GE P S E+ EG A++ + ASA++S +P +
Sbjct: 81 SPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAEPGSPTAAEGEAASAASSTSSPKAED 140
Query: 814 SQGPAPSPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQAEGPTALGTGGPAR 873
P+PS + S +L F K KE+ E AE P A G
Sbjct: 141 GATPSPSNETPKKKKKRFSFKKSFKLSGFSFKKNK-KEAGEGGE--AEAPAAEG------ 191
Query: 874 PEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLRGTESAGAQGTAGLFSQGGKGLPAAPAR 933
K+ A ++ A +AG +G AG Q K AA A
Sbjct: 192 -----GKDEAAGGAAAAAAEAGAASGEQAAAPGEEAAAGEEGAAGGDPQEAKPQEAAVA- 245
Query: 934 GDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRGAEPAAKSAFGQLPSCATAG 987
P P ++ +A+ S K + + E A +A + PS A G
Sbjct: 246 --PEKPPASDETKAAEEPS---------KVEEKKAEEAGASAAACEAPSAAGPG 288
Score = 30.8 bits (68), Expect = 8.1
Identities = 27/81 (33%), Positives = 35/81 (43%), Gaps = 11/81 (13%)
Query: 143 AKSGAAQP-GAGGAQPGAAQPSRAAGGGSRCKP------EPAHGSAPTALCPP--KLVP- 192
A+SGA + A G+ P A + AA G P EPA +AP A P K P
Sbjct: 50 AESGAKEELQANGSAPAADKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPA 109
Query: 193 -GSGGGPGSQVGSSKDQGSAS 212
G PGS + + SA+
Sbjct: 110 EGEAAEPGSPTAAEGEAASAA 130
Score = 30.8 bits (68), Expect = 8.1
Identities = 24/76 (31%), Positives = 28/76 (36%), Gaps = 1/76 (1%)
Query: 138 QEYLKAKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTALCPPKLVPGSGGG 197
+E A SGAA P A AA + AG K PA G A P G
Sbjct: 70 EEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAEP-GSPTAAEGEAAS 128
Query: 198 PGSQVGSSKDQGSASP 213
S S K + A+P
Sbjct: 129 AASSTSSPKAEDGATP 144
>gi|47578107 delangin isoform B [Homo sapiens]
Length = 2697
Score = 47.4 bits (111), Expect = 8e-05
Identities = 64/283 (22%), Positives = 105/283 (37%), Gaps = 36/283 (12%)
Query: 188 PKLVPGSGGG--PGSQVGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNE-----KRQH 240
P+ G+ GG P SQ S GS + VS D Q+ R + + + + K+
Sbjct: 511 PQEAGGATGGNRPASQETGSTGNGSRPALMVSID--LHQAGRVDSQASITQDSDSIKKPE 568
Query: 241 ETQKC-DGSVEKKPDTNENSAKSLLKSHQEPPTKV----VHRQGLLGVQKEFAFRKPP-- 293
E ++C D V + S KS ++H E P K + + + + A KP
Sbjct: 569 EIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNEN 628
Query: 294 RLAKMNVQPRSLRSKVTT-TQENEGSTKPATPCRPSEAA-----------------QNKG 335
RL + L +KV T T+E + + T C+ +E+ NK
Sbjct: 629 RLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQ 688
Query: 336 GIKRSASAARRGKRVMSAAQASEASDSSSDDGIEEAIQLYQ--LQKTRKEADGDLPQRVQ 393
RS + R + ++ + DG E + +T K+ P+ +
Sbjct: 689 NNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPK 748
Query: 394 LREERAPDPPAHSTSSATKSALPETHRKTPSKKKLVATKTMDP 436
+ E P+ P H + S P T +K K TK+ P
Sbjct: 749 QKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSP 791
Score = 38.9 bits (89), Expect = 0.030
Identities = 101/486 (20%), Positives = 191/486 (39%), Gaps = 82/486 (16%)
Query: 268 QEPPTKVVHRQGLLGVQKEFAFR-KPPRLAKMN-VQPRSLRSKVTTTQENEGSTKPATPC 325
++P T VV Q + Q + LA++ ++ S + ++E + KP
Sbjct: 446 KQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKR 505
Query: 326 RPSEAAQNKGGIKRSASAARRGKRVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRKEA- 384
+ Q GG A G R A+Q + ++ + S + +I L+Q + +A
Sbjct: 506 KQDSYPQEAGG-------ATGGNR--PASQETGSTGNGSRPALMVSIDLHQAGRVDSQAS 556
Query: 385 ---DGDL---PQRVQLREERAPDPPAHSTSSATKSALPETHRKTPSKKKLVATKTMDPGP 438
D D P+ ++ + AP + + PE H +TP KK
Sbjct: 557 ITQDSDSIKKPEEIKQCND-APVSVLQEDIVGSLKSTPENHPETPKKKS----------- 604
Query: 439 GGLDTDHAPKLLKETKAPPPASPASRSEFVERSSC--RADTSAELMCAEAILDISKTILP 496
D + + +K++++ S + + VE S + +T E E + S+T
Sbjct: 605 ---DPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRT--- 658
Query: 497 APVEGSDGSLSASPLFYSPNVPSRSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGE 556
++ + S + P +++ S +D+ + R+ K++ + +GE
Sbjct: 659 -----TECKQNESTIVE----PKQNENRLSDTKPNDNKQNNGRSETT-KSRPETPKQKGE 708
Query: 557 SCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGGHVRPSTPKKMQEVVKD 616
S P+ + ++ GH +TP K++G G RP TPK+ E +
Sbjct: 709 SRPETPK---------QKSDGHP----ETP--------KQKGDG--RPETPKQKGESRPE 745
Query: 617 GSQDADHSQGRAE-PGHERRDLPIQGKASEALGGEGTARGPGDTRMSQGQGKTDEARRLD 675
+ + +GR E P H + GK S E ++ DT+ + K++ A L
Sbjct: 746 TPKQKN--EGRPETPKHRHDNRRDSGKPSTEKKPE-VSKHKQDTKSDSPRLKSERAEALK 802
Query: 676 EKESSEDKSSSLDSDEDLDTAIKDLLRSKRKL--KKRCREP---RAACRKK--VRFSTAQ 728
++ S SL D D D S+R + R R P R++ R + ++ +++
Sbjct: 803 QRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSK 862
Query: 729 THFLEQ 734
T LE+
Sbjct: 863 TDKLER 868
>gi|47578105 delangin isoform A [Homo sapiens]
Length = 2804
Score = 47.4 bits (111), Expect = 8e-05
Identities = 64/283 (22%), Positives = 105/283 (37%), Gaps = 36/283 (12%)
Query: 188 PKLVPGSGGG--PGSQVGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNE-----KRQH 240
P+ G+ GG P SQ S GS + VS D Q+ R + + + + K+
Sbjct: 511 PQEAGGATGGNRPASQETGSTGNGSRPALMVSID--LHQAGRVDSQASITQDSDSIKKPE 568
Query: 241 ETQKC-DGSVEKKPDTNENSAKSLLKSHQEPPTKV----VHRQGLLGVQKEFAFRKPP-- 293
E ++C D V + S KS ++H E P K + + + + A KP
Sbjct: 569 EIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNEN 628
Query: 294 RLAKMNVQPRSLRSKVTT-TQENEGSTKPATPCRPSEAA-----------------QNKG 335
RL + L +KV T T+E + + T C+ +E+ NK
Sbjct: 629 RLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQ 688
Query: 336 GIKRSASAARRGKRVMSAAQASEASDSSSDDGIEEAIQLYQ--LQKTRKEADGDLPQRVQ 393
RS + R + ++ + DG E + +T K+ P+ +
Sbjct: 689 NNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPK 748
Query: 394 LREERAPDPPAHSTSSATKSALPETHRKTPSKKKLVATKTMDP 436
+ E P+ P H + S P T +K K TK+ P
Sbjct: 749 QKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSP 791
Score = 38.9 bits (89), Expect = 0.030
Identities = 101/486 (20%), Positives = 191/486 (39%), Gaps = 82/486 (16%)
Query: 268 QEPPTKVVHRQGLLGVQKEFAFR-KPPRLAKMN-VQPRSLRSKVTTTQENEGSTKPATPC 325
++P T VV Q + Q + LA++ ++ S + ++E + KP
Sbjct: 446 KQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKR 505
Query: 326 RPSEAAQNKGGIKRSASAARRGKRVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRKEA- 384
+ Q GG A G R A+Q + ++ + S + +I L+Q + +A
Sbjct: 506 KQDSYPQEAGG-------ATGGNR--PASQETGSTGNGSRPALMVSIDLHQAGRVDSQAS 556
Query: 385 ---DGDL---PQRVQLREERAPDPPAHSTSSATKSALPETHRKTPSKKKLVATKTMDPGP 438
D D P+ ++ + AP + + PE H +TP KK
Sbjct: 557 ITQDSDSIKKPEEIKQCND-APVSVLQEDIVGSLKSTPENHPETPKKKS----------- 604
Query: 439 GGLDTDHAPKLLKETKAPPPASPASRSEFVERSSC--RADTSAELMCAEAILDISKTILP 496
D + + +K++++ S + + VE S + +T E E + S+T
Sbjct: 605 ---DPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRT--- 658
Query: 497 APVEGSDGSLSASPLFYSPNVPSRSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGE 556
++ + S + P +++ S +D+ + R+ K++ + +GE
Sbjct: 659 -----TECKQNESTIVE----PKQNENRLSDTKPNDNKQNNGRSETT-KSRPETPKQKGE 708
Query: 557 SCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGGHVRPSTPKKMQEVVKD 616
S P+ + ++ GH +TP K++G G RP TPK+ E +
Sbjct: 709 SRPETPK---------QKSDGHP----ETP--------KQKGDG--RPETPKQKGESRPE 745
Query: 617 GSQDADHSQGRAE-PGHERRDLPIQGKASEALGGEGTARGPGDTRMSQGQGKTDEARRLD 675
+ + +GR E P H + GK S E ++ DT+ + K++ A L
Sbjct: 746 TPKQKN--EGRPETPKHRHDNRRDSGKPSTEKKPE-VSKHKQDTKSDSPRLKSERAEALK 802
Query: 676 EKESSEDKSSSLDSDEDLDTAIKDLLRSKRKL--KKRCREP---RAACRKK--VRFSTAQ 728
++ S SL D D D S+R + R R P R++ R + ++ +++
Sbjct: 803 QRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSK 862
Query: 729 THFLEQ 734
T LE+
Sbjct: 863 TDKLER 868
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 47.0 bits (110), Expect = 1e-04
Identities = 106/491 (21%), Positives = 160/491 (32%), Gaps = 83/491 (16%)
Query: 147 AAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTALCPPK---------LVPGSGGG 197
A P G P AA P G S P P P A+ PP P S GG
Sbjct: 1302 ATSPPKGAPTPPAATPPSPKG--SPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGG 1359
Query: 198 PGSQVGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQHETQKCDGSVEKKPDTNE 257
P + S +G P + S ++ G P +
Sbjct: 1360 PTTP---SSKEGPTPPAATPSHKGGPAMTPPSPKR--------------GPAIPSPKGDP 1402
Query: 258 NSAKSLLKSHQEPPTKVVHRQGLLGVQK---------EFAFRKPPRLAKMNVQPRSLRSK 308
S + S ++ P V R+G K + +K P + P + SK
Sbjct: 1403 TSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSK 1462
Query: 309 VTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRGKRVMSAAQASE-----ASDSS 363
T P P P + A + K A+ A G + A S A+ SS
Sbjct: 1463 GDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSS 1522
Query: 364 SDDGIEEAIQLYQLQK--TRKEADGDLPQRVQLREER----------APDPPAHSTSSAT 411
D I L + T + +P + + + AP P+ +S+
Sbjct: 1523 RRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSP 1582
Query: 412 KSALPETHRKTPSKKK-LVATKTMDPGPGGLDTDHA-----PKLLKETKAP------PPA 459
+ P T++ PS K+ L+ P P T A P+ T AP PP
Sbjct: 1583 PAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPV 1642
Query: 460 SPAS-RSEFVERSSCRADTSAELMCAEAILDIS------KTILPAPVEGSDGSLSASPLF 512
+P+S + +S A + A L K +L AP S ++A P
Sbjct: 1643 TPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITA-PTR 1701
Query: 513 YSPNVPSRSDGDSSSVDSDDSIEQEIRTFLALKA--------QSGSLLARGESCPQAAQG 564
P +S S + D S + + L+ A + S A+G+ + +G
Sbjct: 1702 KGPQT-KKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKG 1760
Query: 565 PLLPPGLNSQT 575
PL PP + T
Sbjct: 1761 PLAPPESKAST 1771
Score = 44.3 bits (103), Expect = 7e-04
Identities = 77/340 (22%), Positives = 108/340 (31%), Gaps = 55/340 (16%)
Query: 765 PGKKPPSVFGSTAERMRQEGAASQDAALAFRVRRPASASASEGNPFPRESQGPAPSPGSL 824
P PPS GS A +GA + AA + + + +G P P + P+P G
Sbjct: 1036 PAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPA 1095
Query: 825 SDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQAEGPTALG-------TGGPARPEVL 877
+ + K + + A P+ G G P P
Sbjct: 1096 TPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTP--- 1152
Query: 878 CRKEPAPPPGVCTRSQR------ARGVPHLAEGLRGTESAGAQGT---------AGLFSQ 922
P+P G+ T + A P GL GA T GL +
Sbjct: 1153 AATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATP 1212
Query: 923 GGKGLPAAPARGDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRGAEPAAKSAFGQLPS 982
KG P PA P P+ S KG + SP+G P
Sbjct: 1213 SPKGAPTTPA-ATPPSPKGGLATPSPKGAPTTP----AATPPSPKGGPATPPPKGAPTPP 1267
Query: 983 CATAGTEAGGARGTFHMGCGSPSFLT-PSPGAERDAGAQADRTPPWSDFAHQSRLPSPWV 1041
AT + GG H G +P+ +T PSP G A P + + PSP
Sbjct: 1268 AATPPSLKGGLATPPHKGAPNPAVVTPPSP-----KGGPATSPPKGAPTPPAATPPSP-- 1320
Query: 1042 LRSEGRDAVWRGGVGSERDKGSEGP-------ARGLPSLP 1074
+G G+ KG+ P +G P+LP
Sbjct: 1321 ----------KGSPGTPPPKGAPTPPAVTPPSPKGTPTLP 1350
Score = 42.7 bits (99), Expect = 0.002
Identities = 91/392 (23%), Positives = 127/392 (32%), Gaps = 87/392 (22%)
Query: 747 PPVLKSCLSKSKRDSGEGPGKKPPSVFGSTA--------------ERMRQEGAASQDAAL 792
P + KS S S +G PG K T+ E AS L
Sbjct: 728 PEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTL 787
Query: 793 AFRVRRPASASAS-----EGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEIRKFLAE 847
+ P+ S + P + S GP G+LS S V+++ FL E
Sbjct: 788 TYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEAS---------FLPE 838
Query: 848 KAKESVSSSEVQA--EGPTALGTGGPARPEVLCRKEP---------APPPGVCT----RS 892
+ S + A PT G P + P P P V +
Sbjct: 839 NSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKE 898
Query: 893 QRARGVPHLAEGLRGTESAGAQGTAGLFSQGGKGLPAAPA-RGDPVPPRSTSGGVSAKGL 951
A P A L T S+ + A + KG+PA+P+ +G P PP +T
Sbjct: 899 GPATPAPKQAPALSMTSSSPKKARA---TPAPKGIPASPSPKGAPTPPAATPPSPKGGPA 955
Query: 952 SVSRR---NVYVHKDQSPRG--AEPAAKSAFGQLPSCATAGTEAGGARGTFHMGCGSPSF 1006
+ S + SP+G A P+ K A P AT + GG G +P
Sbjct: 956 TPSPKWAPTPPAATPPSPKGGPATPSPKGA--PTPPAATPPSPKGGPATPSPKGAPTPPA 1013
Query: 1007 LTP-----SPGA---ERDAGAQADRTPP-------------WSDFAHQSRLPSPWVLRSE 1045
+TP SP A + A TPP + + LPSP
Sbjct: 1014 VTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSP------ 1067
Query: 1046 GRDAVWRGGVGSERDKGSEGPARGLPSLPLAG 1077
+GG + KG+ P P P G
Sbjct: 1068 ------KGGPATPSLKGAPTPPAATPPSPKGG 1093
Score = 35.8 bits (81), Expect = 0.25
Identities = 77/329 (23%), Positives = 101/329 (30%), Gaps = 56/329 (17%)
Query: 765 PGKKPPSVFGSTAERMRQEGAASQDAALAFRVR-RPASASASEGNPFPRESQGPAPSPGS 823
P PPS GS A +GA++ AA + PA+ +G P + P+P G
Sbjct: 1012 PAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGP 1071
Query: 824 LSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQAEGPTALGTGGPARPEVL------ 877
A S+ + GGPA P
Sbjct: 1072 -------------------------ATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPP 1106
Query: 878 CRKEPAPPPGVCTRSQR------ARGVPHLAEGLRGTESAGAQGTAGLFSQGGKG-LPAA 930
P+P G+ T + A P GL GA T KG L
Sbjct: 1107 AATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATP 1166
Query: 931 PARGDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRGAEPAAKSAFGQLPSCATAGTEA 990
P +G P P +T GL+ SP+GA P +A P A
Sbjct: 1167 PPKGAPTTPAATPPSPKG-GLATP----------SPKGA-PTTPAATPPSPKGGLATPSP 1214
Query: 991 GGARGTFHMGCGSPS--FLTPSPGAERDAGAQADRTPPWSDFAHQSRLPSPWVLRSEGRD 1048
GA T SP TPSP + A TPP + P
Sbjct: 1215 KGAPTTPAATPPSPKGGLATPSP---KGAPTTPAATPPSPKGGPATPPPKGAPTPPAATP 1271
Query: 1049 AVWRGGVGSERDKGSEGPARGLPSLPLAG 1077
+GG+ + KG+ PA P P G
Sbjct: 1272 PSLKGGLATPPHKGAPNPAVVTPPSPKGG 1300
>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
Length = 1312
Score = 46.2 bits (108), Expect = 2e-04
Identities = 137/667 (20%), Positives = 225/667 (33%), Gaps = 96/667 (14%)
Query: 292 PPRLAKMNVQPRSLRSKVTTTQENEGSTKPATPCRPSEAAQNKGGIKR----SASAARRG 347
P R + RS +K + + P P P ++ +++ ++ ++S+ARR
Sbjct: 514 PTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRR 573
Query: 348 KRVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHST 407
R S ++++ S+D + + +K R+ R +P P S+
Sbjct: 574 SRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRR-----------RRSASPPPATSSS 622
Query: 408 SSATKSALPETHRK-TPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAPPPASPASRSE 466
SS+ + HR SKKK +++ G ++ AP APPP+ S +
Sbjct: 623 SSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAP-----APAPPPSGSTSCGD 677
Query: 467 FVERSSCRADTSAELMCAEAILDISKTILPAPVEGSD--GSLSASPLFYSPNVPSRSDGD 524
R S + + + I +TI ++ SD G A V S+G
Sbjct: 678 RDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGL 737
Query: 525 SSSVDSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSK 584
S S +++ R +SG+ + S + ++ L G + +
Sbjct: 738 SGEERGGKSSQKDRR-------RSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDR 790
Query: 585 TPDPLLGCKRKRRGGGHVRPSTPKKMQEVVKDGSQDADHSQGRAEPGHERRDLPIQGKAS 644
+ +K R PS+ + V GS + S + R + +Q K +
Sbjct: 791 S-------SKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSS-----RKVKLQSKVA 838
Query: 645 EALGGEGTARGPGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSK 704
+ ++ P S G G D E +S L DE T +
Sbjct: 839 VLIREGVSSTTPAKDAASAGLGSIGVKFSRDR----ESRSPFLKPDERAPTEMAKAAPGS 894
Query: 705 RKLKKRCREPRAACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEG 764
K KK + +A KK + + +T K ++ K SG G
Sbjct: 895 TKPKKTKVKAKAGA-KKTKGTKGKT---------------------KPSKTRKKVRSGGG 932
Query: 765 PGKKPPSVFGSTAERMRQEGAASQDAALAFRVRRPASASASEGNPFPRESQGPAPSPGSL 824
G V ++ AA A A+ P P+ AP P +L
Sbjct: 933 SGGSGGQVSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPK----AAPPPPAL 988
Query: 825 SDDSSSVDSNDSIELEIRKFLAEKAKESV---SSSEVQAEGPTALGTGGPARPEVLCRKE 881
+ DS +VDS S + FL E+A E +E + E E +E
Sbjct: 989 TPDSQTVDS--SCKTPEVSFLPEEATEEAGVRGGAEEEEE---------EEEEEEEEEEE 1037
Query: 882 PAPPPGVCTRSQRARGVPHLAEGLRGT--ESAGAQGTAGLFSQGGKGLPAAPARGDPVPP 939
P T + A P A T +S G A SQ LP P P P
Sbjct: 1038 EEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQ----LPTLP----PPMP 1089
Query: 940 RSTSGGV 946
+ GV
Sbjct: 1090 WNLPAGV 1096
Score = 43.9 bits (102), Expect = 0.001
Identities = 88/402 (21%), Positives = 143/402 (35%), Gaps = 77/402 (19%)
Query: 106 DPMGEEETTDFGP---LVLDSDSDDSVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGAAQP 162
DP G P ++ DS+ +R + + ++ + +SGAA + + G+ +
Sbjct: 714 DPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKD--RRRSGAASSSSSSREKGSRR- 770
Query: 163 SRAAGGGSRC--------------KPEPAHGSAPTALCPPKLVPGSGGGPGSQVGSSKDQ 208
+A GG R K P SAP++ PPK SG G S
Sbjct: 771 -KALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSS-------- 821
Query: 209 GSASPVSVSSDDSFEQSIRAEIEQFLNEKRQHETQKCD------GSVEKKPDTNENSAKS 262
S SS S + +++++ + E T D GS+ K + S
Sbjct: 822 ------SSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSP 875
Query: 263 LLKSHQEPPTKVV-----HRQGLLGVQKEFAFRKPPRLAKMNVQPRSLRSKVTTTQENEG 317
LK + PT++ + K A K + K +P R KV + + G
Sbjct: 876 FLKPDERAPTEMAKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGG 935
Query: 318 -----STKPATPCRPSEAAQNKGGIKRSASAARRGKRVMSAAQASEA-------SDSSSD 365
S K + S+AA KG + S S R +V S A DS +
Sbjct: 936 SGGQVSLKKSKADSCSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTV 995
Query: 366 DGIEEAIQLYQLQKTRKEADG---------DLPQRVQLREERAPDPPAHSTSSATKSALP 416
D + ++ L + E G + + + EE PA +T+++T +A P
Sbjct: 996 DSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAP 1055
Query: 417 ETHRKTPSKKKLVATKTMDPGPGGLDTDHAPKLLKETKAPPP 458
T PS + GP A ++ + PPP
Sbjct: 1056 ST---APSAGSTAGDSGAEDGP-------ASRVSQLPTLPPP 1087
Score = 40.0 bits (92), Expect = 0.013
Identities = 199/981 (20%), Positives = 314/981 (32%), Gaps = 135/981 (13%)
Query: 153 GGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTALCPPKLVPGSGGGPGSQVGS----SKDQ 208
G G A P + S P P+ S PP P + P + + +
Sbjct: 178 GTGDGGPAPPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEA 237
Query: 209 GSASPVSVSSDDSFEQSIRAEIEQFLNEKRQHETQKCDGSVEKKPDTNENSAKSLLKSHQ 268
S P D FE + + E ++ + E++ D E S S
Sbjct: 238 YSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRI 297
Query: 269 EPPTKVVHRQGLLGVQKEFAFRKPPRLAKMNVQPRSLRSKVTTTQENEGSTKPATPCRPS 328
++ L ++F + PR QP + P TP +
Sbjct: 298 SETLAGIYDDNSLS--QDFPGDESPRPDAQPTQP---------------TPAPGTPPQV- 339
Query: 329 EAAQNKGGIKR-------SASAARRGKRVMSAAQASEASDSS-----SDDGIEEAIQLYQ 376
++ + G ++R A A R GK + A A+ D IEE
Sbjct: 340 DSTRADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEG----- 394
Query: 377 LQKTRKEADGDLPQRVQLREERAPDPPAHSTSSATKSALPETHR-KTPSKKKLVATKTMD 435
+ + E + L + RA P ++++ T LP+ + P ++
Sbjct: 395 -EIVQPEEEPRLALSLFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAES 453
Query: 436 PGPGGLDTDHAPKLLKETKAPPPASPAS--------------RSEFVERSSCRADTSAEL 481
G G L D L E PPA+ + R + +RS A A
Sbjct: 454 DGEGALQVD-----LGEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPA 508
Query: 482 MCA-EAILDISKTILPAPVEGSDGSLSASPLFYSPNVPSRSDGDSSSVDSDDSIEQEIRT 540
A S+ E + + S+S +P P+ S DS S D
Sbjct: 509 AAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPA-SPWDSKKHRSRDRKPGS--- 564
Query: 541 FLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGG 600
S S R S ++ + + GG + S+ +R+RR
Sbjct: 565 -----HASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREK------RRRRRRSA 613
Query: 601 HVRPSTPKKMQEVVKDGSQDADHSQGRAEPGHERRDLPIQGKASEALGGEGTARGPGDTR 660
P+T S+ H + G ++ E G+G+ + P
Sbjct: 614 SPPPATSSS------SSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAP 667
Query: 661 MSQGQ---GKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPRAA 717
G G D RR S +D + D DL AIK + R K R P A
Sbjct: 668 PPSGSTSCGDRDSRRRGAVPPSIQDLT-----DHDL-FAIKRTITVGRLDKSDPRGPSPA 721
Query: 718 CRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEGPGKKPPSVFGSTA 777
+ E L G R K +S + S S E G + ++ G
Sbjct: 722 PASSPKREVLYDS--EGLSGEERGGKSSQKDRRRSGAASSSSSSRE-KGSRRKALDGGDR 778
Query: 778 ERMRQEGAASQDAALAFRVRRPASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSI 837
+R R +D + + RP SA P P+ P S GS S SSS S+ +
Sbjct: 779 DRDRDR---DRDRDRSSKKARPPKESAPSSGPPPK----PPVSSGSGSSSSSSSCSSRKV 831
Query: 838 ELEIRKFLAEKAKESVSSSEVQAEGPTA-LGTGGPARPEVLCRKEPAPPPGVCTRSQRAR 896
+L+ + +A +E VSS+ + +A LG+ G + P P ++ A+
Sbjct: 832 KLQSK--VAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAK 889
Query: 897 GVPHLA--EGLRGTESAGAQGTAG-------------LFSQGGKG-----LPAAPARGDP 936
P + + AGA+ T G + S GG G + ++ D
Sbjct: 890 AAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADS 949
Query: 937 VPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRGA-EPAAKSAFGQL--PSCATAGTEAGGA 993
+ + G S R V P+ A P A + Q SC T
Sbjct: 950 CSQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPE 1009
Query: 994 RGTFHMGCGSPSFLTPSPGAERDAGAQADRTPPWSDFAHQSRLPSPWVLRSEGRDAVWRG 1053
T G + E + + + P + A + +P S G A G
Sbjct: 1010 EATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTA---G 1066
Query: 1054 GVGSERDKGSEGPARGLPSLP 1074
G+E +GPA + LP
Sbjct: 1067 DSGAE-----DGPASRVSQLP 1082
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 46.2 bits (108), Expect = 2e-04
Identities = 178/866 (20%), Positives = 284/866 (32%), Gaps = 198/866 (22%)
Query: 154 GAQPGAAQPSRAAGGGSRCKPEPAHGSAPTALCPPKLVPGSGGGPGSQVGSSKDQGSASP 213
GA P+ GG + PA G+ LC SG G G++ K +
Sbjct: 1429 GAMSDGRVPAEHRQGGGDFRRAPAPGTLQDGLCHSLDRGISGKGEGTE----KSSQAKEL 1484
Query: 214 VSVSSDDSFEQSIRAEIEQFLNEKRQHETQKCDGSVEKKPDTNENSAKSL-------LKS 266
+ DS +I +L +K E ++ + KP S + L
Sbjct: 1485 LRCEKLDSKLANI-----DYLRKKMSLEDKEDNLCPVLKPKMTAGSHECLPGNPVRPTGG 1539
Query: 267 HQEPPTKVVHRQGLLGVQKEFAFRKPPRLAKMN----VQPRSLRSKVTTTQENEGSTKPA 322
QEPP R AF A+M+ V ++L +V + E G P
Sbjct: 1540 QQEPPPASESR----------AFVSSTHAAQMSAVSFVPLKALTGRVDSGTEKPGLVAPE 1589
Query: 323 TPCRPSEAAQNKGGIKRSASAARRGKRVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRK 382
+P R S + G RS S + + + A S S ++ E+ Q
Sbjct: 1590 SPVRKSPSEYKLEG--RSVSCLKPIEGTLDIALLSGPQASKTELPSPESAQ-------SP 1640
Query: 383 EADGDLPQRVQLREERAPDPPAHSTSSATKSALPETHRKTPSKKKLVATKTMDPG--PGG 440
GD+ RA PP +SS K+ +PS K+ + ++P P
Sbjct: 1641 SPSGDV---------RASVPPVLPSSSGKKNDTTSARELSPSSLKMNKSYLLEPWFLPPS 1691
Query: 441 LDTDHAPKLLKETKAPPPASPASRSEFVERSSCRADTSAELMCAEAILDISKTILPAPVE 500
++P + P P R P P
Sbjct: 1692 RGLQNSPAV----SLPDPEFKRDRKG-----------------------------PHPTA 1718
Query: 501 GSDGSLSASPLFYSPNVPSRSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGESCPQ 560
S G++ S P + +G SS D + + ++ T L S L CP
Sbjct: 1719 RSPGTVMESN-------PQQREG-SSPKHQDHTTDPKLLTCLGQNLHSPDLAR--PRCP- 1767
Query: 561 AAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRGGGHVRPSTPKKMQEVVKDGSQD 620
LPP + K L ++ + R R M+ + ++
Sbjct: 1768 ------LPP--EASPSREKPGLRESSERGPPTARSERSAARADTCREPSMELCFPETAKT 1819
Query: 621 ADHSQGRAEPGHERRDLPIQGKASEALGGEGTARGPGDTRMSQGQGKTDEARRLDEKESS 680
+D+S+ G D Q +A E G G T G G+ R +++S
Sbjct: 1820 SDNSKNLLSVGRTHPDFYTQTQAMEKAWAPG-----GKTNHKDGPGEA----RPPPRDNS 1870
Query: 681 EDKSSSLDSDEDLDTAIKDLLRSKRKL--KKRCREPRAACRKKVRFSTAQTHFLEQLGGL 738
S+ + +++L + + L ++ + P K + S+ + L++ G
Sbjct: 1871 SLHSAGIPCEKELGKVRRGVEPKPEALLARRSLQPPGIESEKSEKLSSFPS--LQKDGAK 1928
Query: 739 RRDWK-------------------DRGPPVLKSCLSKSKRDSGEGPGKKPPSVFGSTAER 779
+ K D P + S SG PG KP STAE
Sbjct: 1929 EPERKEQPLQRHPSSIPPPPLTAKDLSSPAARQHCSSPSHASGREPGAKP-----STAE- 1982
Query: 780 MRQEGAASQDAALAFRVRRPASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIEL 839
++ QD +P +A + + PR P P P + D S S+
Sbjct: 1983 ---PSSSPQDPP------KPVAAHSESSSHKPRPGPDPGP-PKTKHPDRSLSSQKPSVGA 2032
Query: 840 EIRKFLAEKAKESVSSSEVQAEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVP 899
K E A +S+ S + +G + G P+V PA P
Sbjct: 2033 TKGK---EPATQSLGGSSREGKGHSKSG------PDVF----PATP-------------- 2065
Query: 900 HLAEGLRGTESAGAQGTAGLFSQGGKGLPAAPARGDPVP----PRSTSGGVSAKGLSVSR 955
G+Q A G+G P+ P D P P+ TSGG + L V
Sbjct: 2066 ------------GSQNKASDGIGQGEGGPSVPLHTDRAPLDAKPQPTSGG---RPLEVLE 2110
Query: 956 RNVYVHKDQSPRGAEPAAK--SAFGQ 979
+ V++ + P +EPA + SA G+
Sbjct: 2111 KPVHLPRPGHPGPSEPADQKLSAVGE 2136
Score = 38.9 bits (89), Expect = 0.030
Identities = 127/616 (20%), Positives = 195/616 (31%), Gaps = 91/616 (14%)
Query: 456 PPPASPASRSEFVERSSCRADTSAELMCAEAILDISKTILPAPVEGSDGSLSASPLFYSP 515
PPPAS E + + T A M A + + + + G S + P +P
Sbjct: 1543 PPPAS--------ESRAFVSSTHAAQMSAVSFVPLKA------LTGRVDSGTEKPGLVAP 1588
Query: 516 NVPSRSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQT 575
P R S + E R+ LK G+L S PQA++ L P
Sbjct: 1589 ESPVRK--------SPSEYKLEGRSVSCLKPIEGTLDIALLSGPQASKTELPSPESAQSP 1640
Query: 576 GGHKTPLSKTPDPLLGCKRKRRGGGHVRPSTPKKMQEVVKDGSQDADHSQGRAEPGHERR 635
+ P L K+ R +P ++ + R
Sbjct: 1641 SPSGDVRASVPPVLPSSSGKKNDTTSARELSPSSLKMNKSYLLEPWFLPPSRGLQNSPAV 1700
Query: 636 DLPIQGKASEALGGEGTARGPGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDT 695
LP + G TAR PG S Q ++E S K +D L T
Sbjct: 1701 SLPDPEFKRDRKGPHPTARSPGTVMESNPQ----------QREGSSPKHQDHTTDPKLLT 1750
Query: 696 AIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKSCLS 755
+ L S + RC P A + + GLR +RGPP +S S
Sbjct: 1751 CLGQNLHSPDLARPRCPLPPEASPSREK------------PGLRES-SERGPPTARSERS 1797
Query: 756 KSKRDSGEGPGKK----PPSVFGSTAERMRQEGAASQDAALAFRVRRPASASASEGNPFP 811
++ D+ P + + ++ + G D + A A + N
Sbjct: 1798 AARADTCREPSMELCFPETAKTSDNSKNLLSVGRTHPDFYTQTQAMEKAWAPGGKTN--- 1854
Query: 812 RESQGPAPSPGSLSDDSSSVDSNDSIELEIRKFL--------AEKAKESVSSSEVQAEGP 863
GP + D+SS + E E+ K A A+ S+ +++E
Sbjct: 1855 -HKDGPGEARPPPRDNSSLHSAGIPCEKELGKVRRGVEPKPEALLARRSLQPPGIESEKS 1913
Query: 864 TAL---------GTGGPARPEVLCRKEPA--PPPGVCTR---SQRARGVPHLAEGLRGTE 909
L G P R E ++ P+ PPP + + S AR G E
Sbjct: 1914 EKLSSFPSLQKDGAKEPERKEQPLQRHPSSIPPPPLTAKDLSSPAARQHCSSPSHASGRE 1973
Query: 910 SAGAQGTAGLFSQGGKGLPAAPARGDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRGA 969
TA S P P + PV S S + H D+S
Sbjct: 1974 PGAKPSTAEPSSS-----PQDPPK--PVAAHSESSSHKPRPGPDPGPPKTKHPDRSLSSQ 2026
Query: 970 EPAAKSAFGQLPSCATAGTEAGGARGTFHMGCGSPSFLTPSPGAERDA------GAQADR 1023
+P+ + G+ P+ + G + +G G P +PG++ A G
Sbjct: 2027 KPSVGATKGKEPATQSLGGSSREGKGHSKSG---PDVFPATPGSQNKASDGIGQGEGGPS 2083
Query: 1024 TPPWSDFAHQSRLPSP 1039
P +D A P P
Sbjct: 2084 VPLHTDRAPLDAKPQP 2099
Score = 33.1 bits (74), Expect = 1.6
Identities = 91/417 (21%), Positives = 148/417 (35%), Gaps = 34/417 (8%)
Query: 449 LLKETKAPPPASPASRSEFVER-SSCRADTSAELMCAEAILDIS-KTILPAPVEGSDGSL 506
LL PP + +SE + S + D + E E L +I P P+ D S
Sbjct: 1897 LLARRSLQPPGIESEKSEKLSSFPSLQKDGAKEPERKEQPLQRHPSSIPPPPLTAKDLSS 1956
Query: 507 SASPLFYSP--NVPSRSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQG 564
A+ S + R G S S Q+ +A ++S S R P +
Sbjct: 1957 PAARQHCSSPSHASGREPGAKPSTAEPSSSPQDPPKPVAAHSESSSHKPRPGPDPGPPKT 2016
Query: 565 PLLPPGLNSQTGGHKTPLSKTP--DPLLGCKRKRRG----GGHVRPSTPKKMQEVVKDGS 618
L+SQ K P L G R+ +G G V P+TP Q DG
Sbjct: 2017 KHPDRSLSSQKPSVGATKGKEPATQSLGGSSREGKGHSKSGPDVFPATPGS-QNKASDGI 2075
Query: 619 QDADHSQGRAEPGHERRDLPIQGKASEALGG------EGTARGPGDTRMSQGQGKTDEAR 672
+ G + P H R P+ K GG E P + +
Sbjct: 2076 GQGEG--GPSVPLHTDR-APLDAKPQPTSGGRPLEVLEKPVHLPRPGHPGPSEPADQKLS 2132
Query: 673 RLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPRAACRKKVR--------F 724
+ EK++ K + +D T K R+ K +P A ++ +
Sbjct: 2133 AVGEKQTLSPKHPKPSTVKDCPTLCKQT--DNRQTDKSPSQPAANTDRRAEGKKCTEALY 2190
Query: 725 STAQTHFLEQ-LGGLRRDWKDRGPPVLKSCLSKSKRDS-GEGPGKKPPSVFGSTAERMRQ 782
+ A+ LE L + + + +G + + K ++ G+GPG + P M++
Sbjct: 2191 APAEGDKLEAGLSFVHSENRLKGAERPAAGVGKGFPEARGKGPGPQKPPTEADKPNGMKR 2250
Query: 783 EGAASQDAALAFRVRRPASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIEL 839
+A+ + +FR S S + FP G + + SD SS+ + +EL
Sbjct: 2251 SPSATGQS--SFRSTALPEKSLSCSSSFPETRAGVREASAASSDTSSAKAAGGMLEL 2305
>gi|148806908 fibronectin type III domain containing 1 [Homo sapiens]
Length = 1894
Score = 45.8 bits (107), Expect = 2e-04
Identities = 183/862 (21%), Positives = 272/862 (31%), Gaps = 191/862 (22%)
Query: 246 DGSVEKKPDTNENSAKSL------------LKSHQEPPTKVVHRQGLLGVQKEFAFRKPP 293
+G +KP A+ L L S ++ P Q ++ R P
Sbjct: 516 NGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQ-----DQKRTLRPPS 570
Query: 294 RLAKMNVQP--RSLRSKVTTTQENEGSTKP----ATPCRPSEAAQNKGGIKRSASAARRG 347
R V P ++R+++ EG KP AT RP AS
Sbjct: 571 RHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTS 630
Query: 348 KRVMSAAQASEASDSSSDDGIEEAIQLYQ----------LQKTRKEADGDLPQRVQLREE 397
R A ++ SD+ L+ L +R+ L R +
Sbjct: 631 HRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPG 690
Query: 398 RAPDPPAHSTSSATKSALPETHRKTPSKKKLVATKTMDPGPGG----LDTD-HAPKLLKE 452
P PA T + + + PS+ + P GG L T H L +
Sbjct: 691 AKPASPARRTPHSGAAEEDSSASAPPSR--------LSPPHGGSSRLLPTQPHLSSPLSK 742
Query: 453 TKAPPPASPASRSEFVERSSCRADTSAELMCAEAILDISKTILPAPVEGSDGSLSASPLF 512
+PA+ S RS+ + S+ L S+T + E SDG
Sbjct: 743 GGKDGEDAPATNSNAPSRSTMSSSVSSHLS--------SRTQVSEGAEASDGE------- 787
Query: 513 YSPNVPSRSDGDSSSVDSDDSIEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLPPGLN 572
S GD D E +T A A L R + P AA G P
Sbjct: 788 --------SHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHK--PFAANGR--SPSRF 835
Query: 573 SQTGGHKTPLSKTPDPLLGCKRKRRGGGHVRPSTPKKMQEVVKDGSQDADHSQGRAEPGH 632
S G + S +P + + R H + K+ + +D H
Sbjct: 836 SIGRGPRLQPSSSPQSTVPSRAHPRVPSH--SDSHPKLSSGIHGDEEDEKPLPATVVNDH 893
Query: 633 ERRDLPIQGKASEALGGEGTARGPGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDED 692
+P + + +RG D R S +G + L KE + S +D
Sbjct: 894 ----VPSSSR-------QPISRGWEDLRRSPQRGAS-----LHRKEPIPENPKSTGADTH 937
Query: 693 LDTAIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKS 752
L + +++ K Q G R PP +S
Sbjct: 938 PQGKYSSLASKAQDVQQSTDADTEGHSPKA-----------QPGSTDRHASPARPPAARS 986
Query: 753 CLSKS---KRDSGEGPGKKPPSVFGSTAE----RMRQEGAASQDAALAFRVR---RPASA 802
S + G P ++PP ++ + R G + L+ RP S
Sbjct: 987 QQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQ 1046
Query: 803 --SASEGNPFPRESQGPAPSP---------GSLSDDSSSVDSNDSIELEIRKFL-AEKAK 850
S S +P+ S+G P+ GS DDS+ V++ D +R A +AK
Sbjct: 1047 GRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQD-----VRAPAHAARAK 1101
Query: 851 ESVSS--SEVQAEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLRGT 908
E+ +S Q E PT G GG RSQR H A R +
Sbjct: 1102 EAAASLPKHQQVESPTGAGAGGD------------------HRSQRG----HAASPARPS 1139
Query: 909 ESAGAQGTAGLFSQGGKGLPAAPARGDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQS--- 965
G Q A + S+ AAP + +P R S S S+++V D+
Sbjct: 1140 RPGGPQSRARVPSR------AAPGKSEPPSKRPLS--------SKSQQSVSAEDDEEEDA 1185
Query: 966 ---PRGAEPAAKSAFGQLPSCAT--AGTEAGGA--------------RGTFHMGCGSPSF 1006
G E S+ + PS +T G +A G+ RG P
Sbjct: 1186 GFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRP-- 1243
Query: 1007 LTPSPGAERDAGAQADRTPPWS 1028
L P PG+ A R PP S
Sbjct: 1244 LPPPPGSSPRASHVPSRLPPRS 1265
Score = 35.4 bits (80), Expect = 0.33
Identities = 74/281 (26%), Positives = 105/281 (37%), Gaps = 41/281 (14%)
Query: 781 RQEGAASQDAALAFRVR--RPASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIE 838
R+EG +LA + R P SASAS + + PS + +D+ VDS++
Sbjct: 593 RREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDED-- 650
Query: 839 LEIRKFLAEKAKESVSSSEVQAEGPTALGTGGPAR--PEVLCRKEPAPPPGVCTRSQRAR 896
E+A S+ A+ AL P+R P + R + PG S AR
Sbjct: 651 --------ERAVGSLHPKGAFAQPRPALS---PSRQSPSSVLRDRSSVHPGAKPASP-AR 698
Query: 897 GVPHLAEGLRGTESAGAQ--------GTAGLF----------SQGGKGLPAAPARGDPVP 938
PH + ++ G++ L S+GGK APA P
Sbjct: 699 RTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAP 758
Query: 939 PRSTSGGVSAKGLSVSRRNVYVHKDQSPRGAEPAAKSAFGQLPSCATAGT-EAGGARGTF 997
RST + LS SR V + S + G + ATA T A A G F
Sbjct: 759 SRSTMSSSVSSHLS-SRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHF 817
Query: 998 HMGCGSPSFLTPSPGAERDAGAQADRTPPWSDFAHQSRLPS 1038
H+ P F R + + R P S + QS +PS
Sbjct: 818 HLLRHKP-FAANGRSPSRFSIGRGPRLQPSS--SPQSTVPS 855
Score = 35.0 bits (79), Expect = 0.43
Identities = 53/221 (23%), Positives = 77/221 (34%), Gaps = 36/221 (16%)
Query: 122 DSDSDDSVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGAAQ----PSRAAGGG-------- 169
D D+ S D D E + ++A + AA+ A Q P+ A GG
Sbjct: 1072 DEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGH 1131
Query: 170 --SRCKPEPAHGSAPTALCPPKLVPGSGGGPGSQVGSSKDQGSASPVSVSSDDSFEQS-- 225
S +P G A P + PG P + SSK Q S S + DD E +
Sbjct: 1132 AASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVS----AEDDEEEDAGF 1187
Query: 226 IRAEIEQFLNEKRQHETQKCDGSVEKKPDTN-----ENSAKSLLKSHQEPPTKVVHRQGL 280
+ E L+ SV K P ++ +++ SL K +EP + R G
Sbjct: 1188 FKGGKEDLLS-----------SSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGS 1236
Query: 281 LGVQKEFAFRKPPRLAKMNVQPRSLRSKVTTTQENEGSTKP 321
L K P + + P L + T T P
Sbjct: 1237 LAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHP 1277
Score = 33.9 bits (76), Expect = 0.96
Identities = 148/714 (20%), Positives = 236/714 (33%), Gaps = 143/714 (20%)
Query: 307 SKVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRGKRVMSAAQASEASDSSSDD 366
SK Q E + KP P PS + A A+ + V ++ Q A D D
Sbjct: 458 SKADVEQNTEDNGKPEKP-EPSSPSPR-------APASSQHPSVPASPQGRNAKDLLLD- 508
Query: 367 GIEEAIQLYQLQKTRKEADGDLPQRVQLREERAPDPPAHSTSSATKSALPETHRKTPSKK 426
K + A+G P++ QLR ++A + ST + L
Sbjct: 509 -----------LKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSRE------- 550
Query: 427 KLVATKTMDPGPGGLDTDHAPKLLKETKAPPPASPASRSEFVERSSCRADTSAELMCAEA 486
M P DT + L+ PP+ R++ RA A L E
Sbjct: 551 ----DSPMSPS----DTQDQKRTLR-----PPSRHGHSVVAPGRTAVRARMPA-LPRREG 596
Query: 487 ILDISKTILPAPVEGSDGSLSASPLFYS--------PNVPSRSDGDSSSVDSDDSIEQEI 538
+ ++ P G+ S SASP ++ P++P+ S D+ VDSD+
Sbjct: 597 VDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPA-SLNDNDLVDSDED----- 650
Query: 539 RTFLALKAQSGSLLARGESCPQAAQGPLLPPGLNSQTGGHKTPLSKTPDPLLGCKRKRRG 598
+ A G L P G +Q +P ++P +L +
Sbjct: 651 ---------------------ERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHP 689
Query: 599 GGHVRPSTPKKMQ----EVVKDGSQDADHSQGRAEPGHERRDLPIQGKASEALGGEG--- 651
G +P++P + +D S A S+ G R LP Q S L G
Sbjct: 690 G--AKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDG 747
Query: 652 ------TARGPGDTRMSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKR 705
+ P + MS + + R E +E D D + + + +
Sbjct: 748 EDAPATNSNAPSRSTMSSSV-SSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQ 806
Query: 706 KLKKR---------CREPRAA-CRKKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKS-CL 754
L+ R +P AA R RFS + L+ + R P + S
Sbjct: 807 TLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSD 866
Query: 755 SKSKRDSGEGPGKKPPSVFGSTAERMRQEGAASQDAALAFRVRRPA---SASASEGNPFP 811
S K SG ++ +T ++ Q + + R + AS P P
Sbjct: 867 SHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIP 926
Query: 812 RESQGPAPSPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQAEGPTALGTGGP 871
+P S D+ S LA KA++ S++ EG + G
Sbjct: 927 E-------NPKSTGADTHPQGKYSS--------LASKAQDVQQSTDADTEGHSPKAQPGS 971
Query: 872 ARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLRGTESAGAQGTAGLFSQGGKGLPAAP 931
PA PP RSQ+ VP + T G Q P A
Sbjct: 972 TDRHA----SPARPP--AARSQQHPSVPR-------------RMTPGRAPQQQPPPPVAT 1012
Query: 932 ARGDPVPPRSTSGGVSAK---GLSVSRRNVYVHKDQSPRGAEPAAKSAFGQLPS 982
++ P P +G ++ L+ + R + +S ++P S+ G LP+
Sbjct: 1013 SQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPT 1066
Score = 31.6 bits (70), Expect = 4.8
Identities = 41/159 (25%), Positives = 62/159 (38%), Gaps = 13/159 (8%)
Query: 62 GTSDERAAQRGHRAEGCHDARPAAKPTVHKEPPALAVCGLVADFDPMGEEETTDFGPLVL 121
G + +QRGH A +RP P P+ A G +P + + +
Sbjct: 1120 GAGGDHRSQRGHAASPARPSRPGG-PQSRARVPSRAAPG---KSEPPSKRPLSSKSQQSV 1175
Query: 122 DSDSDDSVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSA 181
++ D+ D + +E L + S P + + G A G ++ + EPA A
Sbjct: 1176 SAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGG----KDADGSLAKEEREPAIALA 1231
Query: 182 PT--ALCPPK--LVPGSGGGP-GSQVGSSKDQGSASPVS 215
P +L P K L P G P S V S SA+ VS
Sbjct: 1232 PRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVS 1270
Score = 30.8 bits (68), Expect = 8.1
Identities = 84/380 (22%), Positives = 123/380 (32%), Gaps = 53/380 (13%)
Query: 5 NASPVVALQSKWEAFGPPGSCRFPRCFS--EADEGVESASVSARVQMLISTLQRDGAARG 62
++SP + S+ P S P+ S DE E + V + + R +RG
Sbjct: 846 SSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRG 905
Query: 63 TSD-ERAAQRGHRAEGCHDARPAAKPTVHKEPPALAVCGLVADFDPMGEEETTDFGPLVL 121
D R+ QRG A K + + P + AD P G+ +
Sbjct: 906 WEDLRRSPQRG--------ASLHRKEPIPENPKSTG-----ADTHPQGKYSSLASKA--- 949
Query: 122 DSDSDDSVDRDIEEAIQEYLKAKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSA 181
D S D D E KA+ G+ A A+P AA+ + R P G A
Sbjct: 950 -QDVQQSTDADTEGHSP---KAQPGSTDRHASPARPPAARSQQHPSVPRRMTP----GRA 1001
Query: 182 PTALCPPKLV-----PG-----SGGGPGSQVGSSKDQGSASPVSVSSDDSFEQSIRAEIE 231
P PP + PG +G P S G P S S A
Sbjct: 1002 PQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSR 1061
Query: 232 QFLNEKRQHETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRK 291
L Q++ + GS + D+ E A+ + + P ++ + K
Sbjct: 1062 GMLPTALQNQDEDAQGSYDD--DSTEVEAQDV----RAPAHAARAKEAAASLPKHQQVES 1115
Query: 292 PPRLAKMNVQPRSLRSKVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRGKRVM 351
P A RS R + PA P RP R+A
Sbjct: 1116 PTG-AGAGGDHRSQRGHAAS---------PARPSRPGGPQSRARVPSRAAPGKSEPPSKR 1165
Query: 352 SAAQASEASDSSSDDGIEEA 371
+ S+ S S+ DD E+A
Sbjct: 1166 PLSSKSQQSVSAEDDEEEDA 1185
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 45.8 bits (107), Expect = 2e-04
Identities = 76/299 (25%), Positives = 105/299 (35%), Gaps = 51/299 (17%)
Query: 912 GAQGTAGLFSQGGKGLPAAPARGDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRGAEP 971
G G+ G GG G AP+ G SGG S+ G + S + + R +P
Sbjct: 2295 GGGGSGGSGGGGGSGGGGAPSGGS-----GHSGGPSSCGGAPS-----TSRSRPSRIPQP 2344
Query: 972 AAKSAFGQLPSCATAGTEAGGARGTFHMGCGSPSFLTPSPGAERDAGAQA-DRTPPWSDF 1030
+ S A++ EA GT +P P PGA +AG A R PP +D
Sbjct: 2345 VRHHPPVLVSSAASSQAEADKMSGT-----STPGPSLPPPGAAPEAGPSAPSRRPPGADA 2399
Query: 1031 AHQSR----LPSPWVLRSEGRDAVWRGGVGSERDKGSEGPARGLPSLPLAGFSPLLSTQL 1086
R +P VL S + A GS D ++ L +LPL
Sbjct: 2400 EGSEREAEPIPKMKVLESPRKGAA--NASGSSPDAPAKDARASLGTLPL----------- 2446
Query: 1087 FHFGKGVSWGGRQAGLFSPHLGLPLQGPSFSAFREAQAGPSPVFGSPHLLAKKDGGPWPT 1146
G +AG S PL P SA P P P +K G W +
Sbjct: 2447 ---------GKPRAGAAS-----PLNSPLSSAVPSLGKEPFP----PSSPLQKGGSFWSS 2488
Query: 1147 RKAQAGLSLHDRRSSGSEESILDLRYRRRVNRDDQEQDALGSDASDFSDTSTEDSGGSS 1205
A G +S+ R D ++ + S AS+ S ST+ +G S
Sbjct: 2489 IPASPASRPGSFTFPGDSDSLQRQTPRHAAPGKDTDRMSTCSSASEQSVQSTQSNGSES 2547
>gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]
Length = 953
Score = 45.8 bits (107), Expect = 2e-04
Identities = 55/229 (24%), Positives = 88/229 (38%), Gaps = 33/229 (14%)
Query: 660 RMSQGQGKTDEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPRAACR 719
R + + + D+ R+ ++E +++ + D ++ R K K K + R P+ R
Sbjct: 434 REREREHERDKERQRRKEEWERERAKRDEKDRQHRDRDREKEREKEKGKPKPRSPQPPSR 493
Query: 720 KKVRFSTAQTHFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEGPGKK-PPSVFGSTAE 778
Q +++ GP V ++ K + P KK SV S A
Sbjct: 494 --------------QAEPPKKEAATTGPQVKRADEWKDPWRRSKSPKKKLGVSVSPSRAR 539
Query: 779 RMRQEGAASQDAALAFRVRRPASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIE 838
R R+ A+S A+ + R +S+ + G+ R S S S SS + S
Sbjct: 540 RRRKTSASSASASNSSRSSSRSSSYSGSGSSRSRSRSSSYSSYSSRSSRHSSFSGSRS-- 597
Query: 839 LEIRKFLAEKAKESVSSSEVQAEGPTALGTGGPARPEVLCRKEPAPPPG 887
S SSS P+ T P RP + + EPAPPPG
Sbjct: 598 ----------RSRSFSSS------PSPSPTPSPHRPSIRTKGEPAPPPG 630
Score = 40.0 bits (92), Expect = 0.013
Identities = 68/308 (22%), Positives = 104/308 (33%), Gaps = 39/308 (12%)
Query: 174 PEPAHGSAPTALCPPKLVP--GSGGGPGSQVGSSKDQGSASPVSVSSDDSFEQSIRAEIE 231
P A A PP+ GSG G GS S + + VS S S S +
Sbjct: 665 PREARRKERPARTPPRRRTLSGSGSGSGSSYSGSSSRSRSLSVSSVSSVSSATSSSSSAH 724
Query: 232 QFLNEKRQHETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRK 291
+E + S + + K KS +E K R K + +
Sbjct: 725 SVDSEDMYADLASPVSSASSRSPAPAQTRKEKGKSKKEDGVKEEKR-------KRDSSTQ 777
Query: 292 PPRLAKMNVQPRSLRSKVTTTQENEGSTKPATPCRPSE-------AAQNKGGIKRSASAA 344
PP+ AK +S + T Q G + T E A +KG KR +
Sbjct: 778 PPKSAKPPAGGKSSQQPSTPQQAPPGQPQQGTFVAHKEIKLTLLNKAADKGSRKRYEPSD 837
Query: 345 RRGKRVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQRVQLREERAPDPPA 404
+ + A + + + D S D +K+ P+R + + +AP PA
Sbjct: 838 KDRQSPPPAKRPNTSPDRGSRD-----------RKSGGRLGSPKPERQRGQNSKAPAAPA 886
Query: 405 HSTSSATKSALPETHRKTPSKKKLVATKTMDPGPGGLDTDHA------PKLLKETKAPPP 458
+ + K+ SK V K DPG + A +LLK+ KA
Sbjct: 887 DRKRQLSPQS------KSSSKVTSVPGKASDPGAASTKSGKASTLSRREELLKQLKAVED 940
Query: 459 ASPASRSE 466
A R++
Sbjct: 941 AIARKRAK 948
>gi|112821681 G protein-regulated inducer of neurite outgrowth 1
[Homo sapiens]
Length = 1008
Score = 45.4 bits (106), Expect = 3e-04
Identities = 103/455 (22%), Positives = 152/455 (33%), Gaps = 82/455 (18%)
Query: 145 SGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTALCPPKLVPGSGGGPGSQVGS 204
SG P + G PG + AG S K EPA G L K G S +
Sbjct: 484 SGKTNPVSSG--PGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEK-----AGLVASGKAA 536
Query: 205 SKDQGSASPVSVSSDDSFEQSIRAEIEQFLNEKRQHETQKCDGSVEKKPD------TNEN 258
G A P++V +D + + Q ++ G V P + +
Sbjct: 537 PTASGKAEPLAVGKEDPVSKG-----KADAGPSGQGDSVSI-GKVVSTPGKTVPVPSGKV 590
Query: 259 SAKSLLKSHQEPPTKVVHRQGLLGVQK--EFAFRKPPRLAKMNVQPRSLRSKVTTTQENE 316
SL K+ P KV G L ++K K A QP+S T E
Sbjct: 591 DPVSLGKAEAIPEGKV----GSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQE 646
Query: 317 GSTKPATP---CRPSEAAQNKGGI------KRSASAARRGKRVMSAAQASEASDSSSDDG 367
G+ P C E Q + K A+ +G+ V S S +
Sbjct: 647 GAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPS 706
Query: 368 IEEAIQLYQLQKTRKEADGDLPQRVQLREERAPD----------PPAHSTSSATKSALPE 417
+ + + L L+KT+ + R L R+P+ P A SS S+L +
Sbjct: 707 LGKVVPL-SLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQ 765
Query: 418 THRKTPSKKKLVATKTMDPGPGGLDTDHAPKLLK-ETKAPPPASPASRSEFVERSSCRAD 476
+ ++ + P PG D+ K E APPP R
Sbjct: 766 KDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPP----------PREDAGTQ 815
Query: 477 TSAELMCAEAILDISKTILPAPVEGSDG---SLSASPLFYSPNVPSRSDGDSSSVDSDDS 533
A+ + A+ +S P +G+ G S A+P +P+ PSR D
Sbjct: 816 AGAQACVSVAVSPMS------PQDGAGGSAFSFQAAP--RAPSPPSRRDAGLQ------- 860
Query: 534 IEQEIRTFLALKAQSGSLLARGESCPQAAQGPLLP 568
++L A +A G PQAA P P
Sbjct: 861 --------VSLGAAETRSVATGPMTPQAAAPPAFP 887
Score = 40.4 bits (93), Expect = 0.010
Identities = 104/453 (22%), Positives = 153/453 (33%), Gaps = 62/453 (13%)
Query: 571 LNSQTGGHKTPLSKTPD---------PLLGCKRKRRGGGHVRPSTPKKMQEVVKDGSQDA 621
+N ++ G P+S P P K + GG P + +K V + A
Sbjct: 479 VNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVAS--GKAA 536
Query: 622 DHSQGRAEPGHERRDLPI-QGKASEALGGEGTARGPGDTRMSQGQ------GKTDEARRL 674
+ G+AEP ++ P+ +GKA G+G + G + G+ GK D
Sbjct: 537 PTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLG 596
Query: 675 DEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPRAACRKKVRFS-TAQTHFLE 733
+ E K SL L + +PRA+ + + + A+T
Sbjct: 597 KAEAIPEGKVGSLP------------LEKGSPVTTTKADPRASGKAQPQSGGKAETKLPG 644
Query: 734 QLGGLRRDWKDRGPPVLKSCLSKSKRDSGEGPGKKPPSVFGSTAERMRQEGAASQDAALA 793
Q G + G LK ++ G +K + E + D+A +
Sbjct: 645 QEGAAAPG--EAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPV---SLGKADSAPS 699
Query: 794 FRVRRPASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIE-LEIRKFLAEKAKES 852
+ P S G P + PS S D ++ S S E + E E
Sbjct: 700 RKTESP-----SLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEP 754
Query: 853 VSSSEVQAEGPTALGTGGPARPEVLCRKEPAPPPGVCTR-------SQRARGVPHLAEGL 905
VSS+E + G L G R C + APPPG TR S A P E
Sbjct: 755 VSSTEASSLGQKDLEAAGAERSP--CPEAAAPPPGPRTRDNFTKAPSWEASAPPPPRED- 811
Query: 906 RGTESAGAQGTAGLF--------SQGGKGLPAAPARGDPVPPRSTSGGVSAKGLSVSRRN 957
GT+ AGAQ + GG A P PP G+ + R+
Sbjct: 812 AGTQ-AGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRS 870
Query: 958 VYVHKDQSPRGAEPAAKSAFGQLPSCATAGTEA 990
V +P+ A P A P A A A
Sbjct: 871 V-ATGPMTPQAAAPPAFPEVRVRPGSALAAAVA 902
Score = 39.7 bits (91), Expect = 0.018
Identities = 76/289 (26%), Positives = 100/289 (34%), Gaps = 26/289 (8%)
Query: 812 RESQGPAPSPGSLSDDSSSVDSNDSIELEIRKFLAEKAK-ESVSSSEVQAEGPTALGTGG 870
R S G A + +D S D I RK +EK ES + + GP + G
Sbjct: 442 RVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLG 501
Query: 871 PARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLRGTESAGAQGTAGLFSQGGKGLPAA 930
A P + EPA +G P +E S A TA GK P A
Sbjct: 502 TAGPPSAVKAEPATG---------GKGDPLSSEKAGLVASGKAAPTAS-----GKAEPLA 547
Query: 931 PARGDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRGAEPAAKSAFGQLPSCATAGTEA 990
+ DPV G S +G SVS + K S G S S A
Sbjct: 548 VGKEDPVSKGKADAGPSGQGDSVS-----IGKVVSTPGKTVPVPSGKVDPVSLGKAEAIP 602
Query: 991 GGARGTFHMGCGSPSFLT-----PSPGAERDAGAQADRTPPWSDFAHQSRLPSPWVLRSE 1045
G G+ + GSP T S A+ +G +A+ P + A L+ E
Sbjct: 603 EGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKE 662
Query: 1046 GRDAVWRGGVGSERDKGSEGPARGLP-SLPLAGFSPLLSTQLFHFGKGV 1093
A + GS R +G P SL A +P T+ GK V
Sbjct: 663 TPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVV 711
Score = 35.4 bits (80), Expect = 0.33
Identities = 182/899 (20%), Positives = 299/899 (33%), Gaps = 119/899 (13%)
Query: 167 GGGSRCKPEPAHGSAPTALCPPKLVPGSGGG--------PGSQVGSSKDQGSASPVSVSS 218
G GS + + PP+ P G G+ G+S G ++ S
Sbjct: 36 GAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPS 95
Query: 219 DDSFEQSIRAEIEQFLNEKRQHETQKCDG-SVEKKPDTNENSAKSLLKSHQEPPTKVVHR 277
F E ET + G S+ P+ + + S + P
Sbjct: 96 PTCFSPQ----------ESPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEP------ 139
Query: 278 QGLLGVQKEFAFRKPPRLAKMNVQPRSLRSKVTTTQENEGSTKPATPCRPSEAAQNKGGI 337
K R P L KM+ + + +E+ GS++ A P +A I
Sbjct: 140 -------KSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPE---I 189
Query: 338 KRSASAARRGKRVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQRVQLREE 397
G+ + + D + + + Y + RKE G L + + +
Sbjct: 190 LGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSS-KTYTVSP-RKEDPGSLRKVDPVSSD 247
Query: 398 RAPDP--PAHSTSSATKSALPETHRK----TPSKKKLVATKTMDPGPGGLDTDHAPKLLK 451
+ DP P + P + K + K LV + DPGP G D P
Sbjct: 248 KV-DPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSG-KADPMPLESM 305
Query: 452 ETKAPPPASPASRSEFVERSSCR-ADTSAELMCAEAILDISKTILPAPVEGSDGSLSASP 510
++ + P + + SS + S+ ++ + T L S G++ P
Sbjct: 306 DSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVP 365
Query: 511 LF-----YSPNVPSRSDGDSSSVDSDDSIEQEIRTFL-ALK----AQSGSL--LARGESC 558
+ + S G+ V +T L +LK SG + ++ G+
Sbjct: 366 ATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMD 425
Query: 559 PQAAQGP-LLPPGLNSQTG---------GHKTPLSKTPDPLLGCKRKRRGGGHVRPSTPK 608
P + P LL PG + G + P+S + + ++ V P +
Sbjct: 426 PMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSG 485
Query: 609 KMQEVVKDGSQDADHSQGRAEPGHERRDLPIQGKASEALGGEGTARGPGDTRMSQGQGKT 668
K V G D S G A P + P G + L E GK
Sbjct: 486 KTNPV-SSGPGDP-RSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKA 543
Query: 669 DEARRLDEKESSEDKSSSLDSDEDLDTAIKDLLRSKRKLKKRCREPRAACRKKVRFSTAQ 728
+ E S+ K+ + S + +I ++ + K + V A+
Sbjct: 544 EPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVP----VPSGKVDPVSLGKAE 599
Query: 729 THFLEQLGGLRRDWKDRGPPVLKSCLSKSKRDSGEGPGKKPPSVFGSTAERMR-QEGAAS 787
++G L + +G PV + +K D GK P G ++ QEGAA+
Sbjct: 600 AIPEGKVGSLPLE---KGSPV-----TTTKADP-RASGKAQPQSGGKAETKLPGQEGAAA 650
Query: 788 QDAALAFRVRRPASASASEGNPFPRESQGPAPS----PGSLSD-DSSSVDSNDSIEL-EI 841
A A +++ ++ + +P P S P SL DS+ +S L ++
Sbjct: 651 PGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKV 710
Query: 842 RKFLAEKAKESVSSSEVQAEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPHL 901
EK K S SS ++ + ALG+ P G R R P
Sbjct: 711 VPLSLEKTKPSSSSRQLDRK---ALGSA-------------RSPEGA--RGSEGRVEPK- 751
Query: 902 AEGLRGTESAGAQGTAGLFSQGGKGLPAAPARGDPVPPRSTSGGVSAKGLSVSRRNVYVH 961
AE + TE A + G L + G + P A P PR+ A S
Sbjct: 752 AEPVSSTE-ASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPP---- 806
Query: 962 KDQSPRGAEPAAKSAFGQLPSCATAGTEAGGARGTFHMGCGSPSFLTPSPGAERDAGAQ 1020
+ G + A++ S + AGG+ +F +P PSP + RDAG Q
Sbjct: 807 PPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQ---AAPR--APSPPSRRDAGLQ 860
>gi|91208420 bassoon protein [Homo sapiens]
Length = 3926
Score = 45.1 bits (105), Expect = 4e-04
Identities = 27/61 (44%), Positives = 32/61 (52%), Gaps = 4/61 (6%)
Query: 146 GAAQPGAG-GAQPGAAQPSRAAGGGSRCKPEPAHGSAPTALCPPKLVPGSGGGPGSQVGS 204
G A PG G G PGA +P A GG + PA G+A + PP PG G GPG GS
Sbjct: 19 GGAGPGPGPGPGPGAGKPPSAPAGGGQL---PAAGAARSTAVPPVPGPGPGPGPGPGPGS 75
Query: 205 S 205
+
Sbjct: 76 T 76
Score = 36.2 bits (82), Expect = 0.19
Identities = 48/218 (22%), Positives = 85/218 (38%), Gaps = 24/218 (11%)
Query: 140 YLKAKSGAAQPGAGG-AQP----GAAQPSRAAGGGSRCKPEPAHGSAPTALC----PPKL 190
YL + A PGAGG ++P GAA+ E A AP L P
Sbjct: 2281 YLGKPAAAKAPGAGGPSRPEMPVGAAREEPLPTTTPAAIKEAAGAPAPAPLAGQKPPADA 2340
Query: 191 VPGSGGGPGSQVGSSKDQGSASPVSVSSDDSFEQ--SIRAEIEQFLNEKRQHETQKCDGS 248
PG G G S+ G K++ S + Q R E+E+ + Q E ++
Sbjct: 2341 APGGGSGALSRPGFEKEEASQEERQRKQQEQLLQLERERVELEKLRQLRLQEELERERVE 2400
Query: 249 VEKKPDTNENSAKSLLKSHQEPPTKVV-----HRQGLLGVQKEFAFRKPPRLAKMNVQPR 303
+++ + + + L+ Q V+ RQ +Q+E ++ +L ++ +
Sbjct: 2401 LQRHREEEQLLVQRELQELQTIKHHVLQQQQEERQAQFALQREQLAQQRLQLEQIQQLQQ 2460
Query: 304 SLRSKVTTTQENEGSTKPAT--------PCRPSEAAQN 333
L+ ++ ++ + + PA P +E AQN
Sbjct: 2461 QLQQQLEEQKQRQKAPFPAACEAPGRGPPLAAAELAQN 2498
Score = 34.3 bits (77), Expect = 0.74
Identities = 33/120 (27%), Positives = 41/120 (34%), Gaps = 6/120 (5%)
Query: 760 DSGEGPGKKPPSVFGSTAERMRQEGAASQDAALAFRVRRPASASASEGN----PFPRESQ 815
+ G G G PP G GA +A A + PA+ +A P P
Sbjct: 8 EGGAGDGPLPPGGAGPGPGPGPGPGAGKPPSAPAGGGQLPAAGAARSTAVPPVPGPGPGP 67
Query: 816 GPAPSPGSLSD--DSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQAEGPTALGTGGPAR 873
GP P PGS S D N K + S E +A+GP GP R
Sbjct: 68 GPGPGPGSTSRRLDPKEPLGNQRAASPTPKQASATTPGHESPRETRAQGPAGQEADGPRR 127
Score = 30.8 bits (68), Expect = 8.1
Identities = 66/315 (20%), Positives = 99/315 (31%), Gaps = 46/315 (14%)
Query: 176 PAHGSAPTALCPPKLVPGSGGGPGSQVGSSKDQGSASPVSVSSDDSFEQSIRAEIEQFLN 235
P G AP A P G G GPG+ K G+ SP ++ A+ +
Sbjct: 404 PGPGPAPGAKTEPGARMGPGSGPGA---LPKTGGTTSPKHGRAEHQAASKAAAKPKTMPK 460
Query: 236 EKRQHETQKCDGSVEKKPDTNENSAKSLLKSHQEPPTKVVHRQGLLGVQKEFAFRKPPRL 295
E+ + + +V K N N+ + L V F P L
Sbjct: 461 ERAICPLCQAELNVGSKSPANYNTCTTC----------------RLQVCNLCGFNPTPHL 504
Query: 296 AKMNVQPRSLRSKVTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAAR-------RGK 348
+ + L T + EGS TP P + Q G AS +G
Sbjct: 505 VE---KTEWLCLNCQTKRLLEGSLGEPTPLPPPTSQQPPVGAPHRASGTSPLKQKGPQGL 561
Query: 349 RVMSAAQASEASDSSSDDGIEEAIQLYQLQKTRKEADGDLPQRVQLREERAP-------- 400
S ++AS S+ + Q + R P VQ ++ R P
Sbjct: 562 GQPSGPLPAKASPLSTKASPLPSKASPQAKPLRASEPSKTPSSVQEKKTRVPTKAEPMPK 621
Query: 401 DPPAHSTSSATKSALPETHRKTPSKKKLVATKTMDPG---------PGGLDTDHAPKLLK 451
PP + + AT R P+ + A G P D +P+ L
Sbjct: 622 PPPETTPTPATPKVKSGVRRAEPATPVVKAVPEAPKGGEAEDLVGKPYSQDASRSPQSLS 681
Query: 452 ETKAPPPASPASRSE 466
+T +S+SE
Sbjct: 682 DTGYSSDGISSSQSE 696
Score = 30.8 bits (68), Expect = 8.1
Identities = 26/85 (30%), Positives = 35/85 (41%), Gaps = 13/85 (15%)
Query: 853 VSSSEVQAEGPTALG---------TGGPARPEV---LCRKEPAPPPGVCTRSQRARG-VP 899
++SS AEGP LG GGP+RPE+ R+EP P + A P
Sbjct: 2269 IASSVPPAEGPVYLGKPAAAKAPGAGGPSRPEMPVGAAREEPLPTTTPAAIKEAAGAPAP 2328
Query: 900 HLAEGLRGTESAGAQGTAGLFSQGG 924
G + A G +G S+ G
Sbjct: 2329 APLAGQKPPADAAPGGGSGALSRPG 2353
>gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens]
Length = 1499
Score = 44.7 bits (104), Expect = 5e-04
Identities = 95/352 (26%), Positives = 119/352 (33%), Gaps = 50/352 (14%)
Query: 744 DRGPPVLKSCLSKSKRDSGEGPGKKPPSVFGSTAERMRQEGAASQDAALAFR----VRRP 799
D GPP L+ +R PG K G E+ EG A D A P
Sbjct: 754 DTGPPGLQGM--PGERGIAGTPGPKGDR--GGIGEK-GAEGTAGNDGARGLPGPLGPPGP 808
Query: 800 ASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQ 859
A + +G P PR GP PGS + S ++ + + F + + + +
Sbjct: 809 AGPTGEKGEPGPRGLVGP---PGSRGNPGSRGENGPTGAV---GFAGPQGPDGQPGVKGE 862
Query: 860 AEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLRGTESAGAQGTAGL 919
P G G P+ L A PG GVP L +G RGT+ G G G
Sbjct: 863 PGEPGQKGDAGSPGPQGL-----AGSPG----PHGPNGVPGL-KGGRGTQ--GPPGATGF 910
Query: 920 FSQGGKGLPAAPARG-DPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRG--------AE 970
G+ P PA P P G GL + D+ P G +
Sbjct: 911 PGSAGRVGPPGPAGAPGPAGPLGEPGKEGPPGLRGDPGSHGRVGDRGPAGPPGGPGDKGD 970
Query: 971 PAAKSAFGQLPSCATAGTEAGGARGTFHM-----GCGSPSFLTP--SPGAERDAGAQADR 1023
P G AGT G RG M G P P +PG GA D+
Sbjct: 971 PGEDGQPGPDGPPGPAGTT--GQRGIVGMPGQRGERGMPGLPGPAGTPGKVGPTGATGDK 1028
Query: 1024 TPPWSDFAHQSRLP--SPWVLRSEGRDAV--WRGGVGSERDKGSEGPARGLP 1071
PP S P P G D G VG D+G GPA GLP
Sbjct: 1029 GPPGPVGPPGSNGPVGEPGPEGPAGNDGTPGRDGAVGERGDRGDPGPA-GLP 1079
Score = 42.4 bits (98), Expect = 0.003
Identities = 66/215 (30%), Positives = 83/215 (38%), Gaps = 37/215 (17%)
Query: 862 GPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLRGTESAGAQGTAGLFS 921
GPT G GP P+ R E PP V G P L + + GA+G G S
Sbjct: 390 GPT--GARGPEGPQGQ-RGETGPPGPV--------GSPGLPGAIGTDGTPGAKGPTG--S 436
Query: 922 QGGKGLPAAPARGDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRGAEPAAKSAFGQLP 981
G G P + P+ ++G +G + P+G EP G +
Sbjct: 437 PGTSGPPGSAGPPGSPGPQGSTGPQGIRGQPGDPGVPGFKGEAGPKG-EPGPHGIQGPI- 494
Query: 982 SCATAGTEAGGARGTFHMGCGSPSFLTPSPGAERDAGAQADRTPPWSDFAHQSRLPSPWV 1041
G E G RG G P + P PG + GA +R P SD LP P
Sbjct: 495 --GPPGEE--GKRGPR----GDPGTVGP-PGPVGERGAPGNRGFPGSD-----GLPGPKG 540
Query: 1042 LRSEGRDAVWRGGVGSERDKGSEG-PAR-GLPSLP 1074
+ E RG VGS KGS+G P R G P LP
Sbjct: 541 AQGE------RGPVGSSGPKGSQGDPGRPGEPGLP 569
Score = 33.5 bits (75), Expect = 1.3
Identities = 38/153 (24%), Positives = 52/153 (33%), Gaps = 22/153 (14%)
Query: 799 PASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEV 858
P A +G P P S G PGS+ S D + + +
Sbjct: 589 PLGAPGEDGRPGPPGSIGIRGQPGSMGLPGPKGSSGDP---------GKPGEAGNAGVPG 639
Query: 859 QAEGPTALGTGGPARPEVLCRKEPAPPPGVC-TRSQRARGVPHLAEGLRGTESAGAQGTA 917
Q P G GP+ P PPG+ R ++ P +GL G G G
Sbjct: 640 QRGAPGKDGEVGPSGP--------VGPPGLAGERGEQGPPGPTGFQGLPGPP--GPPGEG 689
Query: 918 GLFSQGGKGLPAAPARGDPVPPRSTSGGVSAKG 950
G G +G+P P P+ PR G +G
Sbjct: 690 G--KPGDQGVPGDPGAVGPLGPRGERGNPGERG 720
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 44.3 bits (103), Expect = 7e-04
Identities = 47/177 (26%), Positives = 65/177 (36%), Gaps = 26/177 (14%)
Query: 746 GPPVLKSCLSKSKRDSGEGPGKKP-PSVFGSTAERMRQEGAASQDAALAFRVRRPASASA 804
GP + L + +D G GPGK P P FG+TA+ GA + R+R A +
Sbjct: 2766 GPGAERLPLHSTPKDGGPGPGKAPWPGDFGTTAKESSGNGAPEE------RLRENGDALS 2819
Query: 805 SEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEVQAEGPT 864
EG+ P P G L S S L + + S+SE GP
Sbjct: 2820 REGSLGPLPGSSAQPHKGILKKKCLPTISEKSSLLRLPLEQCTGSSRGSSASEGSRGGP- 2878
Query: 865 ALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLR-GTESAGAQGTAGLF 920
P PPP + Q GV +A ++ GT + G+ LF
Sbjct: 2879 ----------------PPRPPPRQSLQEQ-LNGVMPIAMSIKAGTVDEDSSGSEFLF 2918
>gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Homo
sapiens]
Length = 1487
Score = 43.9 bits (102), Expect = 0.001
Identities = 83/304 (27%), Positives = 103/304 (33%), Gaps = 60/304 (19%)
Query: 799 PASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEV 858
PA ++ + G P R GP P P + + + K ++ + +
Sbjct: 811 PAGSAGARGAPGERGETGP-PGPAGFAGPPGADGQPGA-----------KGEQGEAGQKG 858
Query: 859 QAEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGV--PHLAEGLRGTESAGAQGT 916
A P G G P+ P GV T + ARG P A G G +AG G
Sbjct: 859 DAGAPGPQGPSGAPGPQ--------GPTGV-TGPKGARGAQGPPGATGFPG--AAGRVGP 907
Query: 917 AGLFSQGGKGLPAAP----------ARGDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSP 966
G S G G P P ARGD PP +G +G + D P
Sbjct: 908 PG--SNGNPGPPGPPGPSGKDGPKGARGDSGPP-GRAGEPGLQGPAGPPGEKGEPGDDGP 964
Query: 967 RGAE--PAAKSAFGQLPSCATAGTEAGGARGTFHMGCGSPSFLTPSPGAERDAGAQADRT 1024
GAE P + GQ G G RG G PS PG + GA DR
Sbjct: 965 SGAEGPPGPQGLAGQRGIVGLPGQR--GERG--FPGLPGPS---GEPGKQGAPGASGDRG 1017
Query: 1025 PP--------WSDFAHQSRLPSPWVLRSEGRDAVWRGGVGSERDKGSEGPARGLPSLPLA 1076
PP R SP GRD G G + D+G G A G P P
Sbjct: 1018 PPGPVGPPGLTGPAGEPGREGSPGADGPPGRD----GAAGVKGDRGETG-AVGAPGAPGP 1072
Query: 1077 GFSP 1080
SP
Sbjct: 1073 PGSP 1076
Score = 38.1 bits (87), Expect = 0.051
Identities = 60/228 (26%), Positives = 79/228 (34%), Gaps = 49/228 (21%)
Query: 849 AKESVSSSEVQAEG--PTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLR 906
AK + V+ E P G+ GP P L PG +R R P A G R
Sbjct: 298 AKGEAGAPGVKGESGSPGENGSPGPMGPRGL--------PG-----ERGRTGPAGAAGAR 344
Query: 907 GTES----AGAQGTAGLFSQGGKGLPAAPARGDPVPPRSTSGGVSAKGLSVSRRNVYVHK 962
G + AG G G GG G P AP P G A+G
Sbjct: 345 GNDGQPGPAGPPGPVG--PAGGPGFPGAPGAKGEAGPTGARGPEGAQG------------ 390
Query: 963 DQSPRGAEPAAKSAFGQLPSCATAGTEA-GGARGTFHMG--CGSPSFLTPSPGAERDAGA 1019
PRG EP + G + GT+ GA+G+ G+P F PG G
Sbjct: 391 ---PRG-EPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGF----PGPRGPPGP 442
Query: 1020 QADRTPPWSDFAHQSRLPSPWVLRSEGRDAVWRGGVGSERDKGSEGPA 1067
Q P + + P + +G +G G +G+ GPA
Sbjct: 443 QGATGP----LGPKGQTGEPGIAGFKGEQGP-KGEPGPAGPQGAPGPA 485
Score = 35.0 bits (79), Expect = 0.43
Identities = 75/287 (26%), Positives = 96/287 (33%), Gaps = 29/287 (10%)
Query: 799 PASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEI------RKFLAEKAKES 852
P + G P+ + GPA PG+ + I R + EK E
Sbjct: 718 PRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEG 777
Query: 853 VSSSEVQAEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLRG-TESA 911
+ +G GPA K PPG S ARG P G RG T
Sbjct: 778 APGKDGGRGLTGPIGPPGPAGAN--GEKGEVGPPGP-AGSAGARGAP----GERGETGPP 830
Query: 912 GAQGTAGLFSQGGKGLPAAPARGDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRGAEP 971
G G AG G G P A + +G +G S + Q P G
Sbjct: 831 GPAGFAG--PPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGA------PGPQGPTGVTG 882
Query: 972 AAKSAFGQLPSCATAGTEAGGARGT--FHMGCGSPSFLTPSPGAERDAGAQADRTPPWSD 1029
+ Q P AT A G G + G P PS G + GA+ D PP
Sbjct: 883 PKGARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPS-GKDGPKGARGDSGPPGR- 940
Query: 1030 FAHQSRLPSPWVLRSEGRDAVWRGGVGSERDKGSEGPA--RGLPSLP 1074
A + L P E + G G+E G +G A RG+ LP
Sbjct: 941 -AGEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLP 986
Score = 32.3 bits (72), Expect = 2.8
Identities = 26/71 (36%), Positives = 29/71 (40%), Gaps = 4/71 (5%)
Query: 143 AKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTALCPPKLVPGSGGGPGSQV 202
A+ PGA G PGAA R GS P P P+ PK G G PG +
Sbjct: 886 ARGAQGPPGATGF-PGAA--GRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPG-RA 941
Query: 203 GSSKDQGSASP 213
G QG A P
Sbjct: 942 GEPGLQGPAGP 952
>gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Homo
sapiens]
Length = 1418
Score = 43.9 bits (102), Expect = 0.001
Identities = 83/304 (27%), Positives = 103/304 (33%), Gaps = 60/304 (19%)
Query: 799 PASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEIRKFLAEKAKESVSSSEV 858
PA ++ + G P R GP P P + + + K ++ + +
Sbjct: 742 PAGSAGARGAPGERGETGP-PGPAGFAGPPGADGQPGA-----------KGEQGEAGQKG 789
Query: 859 QAEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGV--PHLAEGLRGTESAGAQGT 916
A P G G P+ P GV T + ARG P A G G +AG G
Sbjct: 790 DAGAPGPQGPSGAPGPQ--------GPTGV-TGPKGARGAQGPPGATGFPG--AAGRVGP 838
Query: 917 AGLFSQGGKGLPAAP----------ARGDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSP 966
G S G G P P ARGD PP +G +G + D P
Sbjct: 839 PG--SNGNPGPPGPPGPSGKDGPKGARGDSGPP-GRAGEPGLQGPAGPPGEKGEPGDDGP 895
Query: 967 RGAE--PAAKSAFGQLPSCATAGTEAGGARGTFHMGCGSPSFLTPSPGAERDAGAQADRT 1024
GAE P + GQ G G RG G PS PG + GA DR
Sbjct: 896 SGAEGPPGPQGLAGQRGIVGLPGQR--GERG--FPGLPGPS---GEPGKQGAPGASGDRG 948
Query: 1025 PP--------WSDFAHQSRLPSPWVLRSEGRDAVWRGGVGSERDKGSEGPARGLPSLPLA 1076
PP R SP GRD G G + D+G G A G P P
Sbjct: 949 PPGPVGPPGLTGPAGEPGREGSPGADGPPGRD----GAAGVKGDRGETG-AVGAPGAPGP 1003
Query: 1077 GFSP 1080
SP
Sbjct: 1004 PGSP 1007
Score = 38.1 bits (87), Expect = 0.051
Identities = 60/228 (26%), Positives = 79/228 (34%), Gaps = 49/228 (21%)
Query: 849 AKESVSSSEVQAEG--PTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLR 906
AK + V+ E P G+ GP P L PG +R R P A G R
Sbjct: 229 AKGEAGAPGVKGESGSPGENGSPGPMGPRGL--------PG-----ERGRTGPAGAAGAR 275
Query: 907 GTES----AGAQGTAGLFSQGGKGLPAAPARGDPVPPRSTSGGVSAKGLSVSRRNVYVHK 962
G + AG G G GG G P AP P G A+G
Sbjct: 276 GNDGQPGPAGPPGPVG--PAGGPGFPGAPGAKGEAGPTGARGPEGAQG------------ 321
Query: 963 DQSPRGAEPAAKSAFGQLPSCATAGTEA-GGARGTFHMG--CGSPSFLTPSPGAERDAGA 1019
PRG EP + G + GT+ GA+G+ G+P F PG G
Sbjct: 322 ---PRG-EPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGF----PGPRGPPGP 373
Query: 1020 QADRTPPWSDFAHQSRLPSPWVLRSEGRDAVWRGGVGSERDKGSEGPA 1067
Q P + + P + +G +G G +G+ GPA
Sbjct: 374 QGATGP----LGPKGQTGEPGIAGFKGEQGP-KGEPGPAGPQGAPGPA 416
Score = 35.0 bits (79), Expect = 0.43
Identities = 75/287 (26%), Positives = 96/287 (33%), Gaps = 29/287 (10%)
Query: 799 PASASASEGNPFPRESQGPAPSPGSLSDDSSSVDSNDSIELEI------RKFLAEKAKES 852
P + G P+ + GPA PG+ + I R + EK E
Sbjct: 649 PRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEG 708
Query: 853 VSSSEVQAEGPTALGTGGPARPEVLCRKEPAPPPGVCTRSQRARGVPHLAEGLRG-TESA 911
+ +G GPA K PPG S ARG P G RG T
Sbjct: 709 APGKDGGRGLTGPIGPPGPAGAN--GEKGEVGPPGP-AGSAGARGAP----GERGETGPP 761
Query: 912 GAQGTAGLFSQGGKGLPAAPARGDPVPPRSTSGGVSAKGLSVSRRNVYVHKDQSPRGAEP 971
G G AG G G P A + +G +G S + Q P G
Sbjct: 762 GPAGFAG--PPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGA------PGPQGPTGVTG 813
Query: 972 AAKSAFGQLPSCATAGTEAGGARGT--FHMGCGSPSFLTPSPGAERDAGAQADRTPPWSD 1029
+ Q P AT A G G + G P PS G + GA+ D PP
Sbjct: 814 PKGARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPS-GKDGPKGARGDSGPPGR- 871
Query: 1030 FAHQSRLPSPWVLRSEGRDAVWRGGVGSERDKGSEGPA--RGLPSLP 1074
A + L P E + G G+E G +G A RG+ LP
Sbjct: 872 -AGEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLP 917
Score = 32.3 bits (72), Expect = 2.8
Identities = 26/71 (36%), Positives = 29/71 (40%), Gaps = 4/71 (5%)
Query: 143 AKSGAAQPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTALCPPKLVPGSGGGPGSQV 202
A+ PGA G PGAA R GS P P P+ PK G G PG +
Sbjct: 817 ARGAQGPPGATGF-PGAA--GRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPG-RA 872
Query: 203 GSSKDQGSASP 213
G QG A P
Sbjct: 873 GEPGLQGPAGP 883
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 43.9 bits (102), Expect = 0.001
Identities = 60/274 (21%), Positives = 108/274 (39%), Gaps = 24/274 (8%)
Query: 149 QPGAGGAQPGAAQPSRAAGGGSRCKPEPAHGSAPTALCPPKLVPGSGGGPGSQVGSSKD- 207
Q A AQ G + + G G P PA P + P + P G G G S+ +
Sbjct: 1425 QRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGS--PARDAPAEGSGEGLNSPSTLEC 1482
Query: 208 -QGSASP-----VSVSSDDSFEQSIRAEIEQFLNEKRQHETQKCD------------GSV 249
GS P S +S D +++R + +FL E R + ++ + +
Sbjct: 1483 SPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEM 1542
Query: 250 EKKPDTNENSAKSLLKSHQEPPTKVVHRQG-LLGVQKEFAFRKPPRLAKMNVQPRSLRSK 308
E + D+ + A+ L K+ E G L GVQ E A ++ + + + R+ +
Sbjct: 1543 EAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQE-ESVRRSERERRATLDQ 1601
Query: 309 VTTTQENEGSTKPATPCRPSEAAQNKGGIKRSASAARRGKRVMSAAQASEASDSSSDDGI 368
V T + + +T+ + ++ K + RR K V+ A+++ +
Sbjct: 1602 VATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSL 1661
Query: 369 EEAIQLYQLQKTRKEADGD-LPQRVQLREERAPD 401
E +Q +L + +EA L RV + + D
Sbjct: 1662 EGELQRSRLGLSDREAQAQALQDRVDSLQRQVAD 1695
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.128 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,310,149
Number of Sequences: 37866
Number of extensions: 3269321
Number of successful extensions: 18474
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 747
Number of HSP's that attempted gapping in prelim test: 15937
Number of HSP's gapped (non-prelim): 3397
length of query: 1209
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1095
effective length of database: 13,930,794
effective search space: 15254219430
effective search space used: 15254219430
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.