Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 4507463
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
sapiens]
(414 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa... 852 0.0
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ... 835 0.0
gi|4507465 transforming growth factor, beta 3 [Homo sapiens] 461 e-130
gi|63025222 transforming growth factor, beta 1 [Homo sapiens] 313 2e-85
gi|4885259 myostatin [Homo sapiens] 102 8e-22
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens] 101 1e-21
gi|5031613 growth differentiation factor 11 precursor [Homo sapi... 99 7e-21
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi... 93 5e-19
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi... 89 7e-18
gi|4504699 inhibin beta A precursor [Homo sapiens] 88 1e-17
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap... 88 2e-17
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap... 87 2e-17
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa... 87 3e-17
gi|145611428 bone morphogenetic protein 8A [Homo sapiens] 87 3e-17
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa... 85 1e-16
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa... 85 1e-16
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa... 85 1e-16
gi|13899338 activin beta E [Homo sapiens] 75 1e-13
gi|61835232 growth differentiation factor 7 preproprotein [Homo ... 73 5e-13
gi|48475062 growth differentiation factor 6 precursor [Homo sapi... 69 8e-12
gi|4503969 growth differentiation factor 5 preproprotein [Homo s... 69 1e-11
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens] 66 5e-11
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa... 64 3e-10
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens] 63 4e-10
gi|153792495 growth differentiation factor 15 [Homo sapiens] 62 1e-09
gi|239757187 PREDICTED: similar to growth differentiation factor... 62 1e-09
gi|110349792 growth differentiation factor 1 [Homo sapiens] 62 1e-09
gi|10190670 growth differentiation factor 3 precursor [Homo sapi... 60 4e-09
gi|7705308 growth differentiation factor 2 [Homo sapiens] 56 7e-08
gi|222352098 nodal precursor [Homo sapiens] 55 9e-08
>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
sapiens]
Length = 414
Score = 852 bits (2202), Expect = 0.0
Identities = 414/414 (100%), Positives = 414/414 (100%)
Query: 1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP 60
MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP
Sbjct: 1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP 60
Query: 61 EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPP 120
EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPP
Sbjct: 61 EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPP 120
Query: 121 TFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSP 180
TFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSP
Sbjct: 121 TFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSP 180
Query: 181 TQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIP 240
TQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIP
Sbjct: 181 TQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIP 240
Query: 241 NKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRK 300
NKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRK
Sbjct: 241 NKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRK 300
Query: 301 KRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQH 360
KRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQH
Sbjct: 301 KRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQH 360
Query: 361 SRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS 414
SRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS
Sbjct: 361 SRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS 414
>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
sapiens]
Length = 442
Score = 835 bits (2158), Expect = 0.0
Identities = 413/442 (93%), Positives = 414/442 (93%), Gaps = 28/442 (6%)
Query: 1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP 60
MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP
Sbjct: 1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP 60
Query: 61 EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSE----- 115
EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSE
Sbjct: 61 EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPV 120
Query: 116 -----------------------NAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF 152
+AIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF
Sbjct: 121 VTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF 180
Query: 153 RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH 212
RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH
Sbjct: 181 RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH 240
Query: 213 HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK 272
HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK
Sbjct: 241 HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK 300
Query: 273 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW 332
KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW
Sbjct: 301 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW 360
Query: 333 KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY 392
KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY
Sbjct: 361 KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY 420
Query: 393 YIGKTPKIEQLSNMIVKSCKCS 414
YIGKTPKIEQLSNMIVKSCKCS
Sbjct: 421 YIGKTPKIEQLSNMIVKSCKCS 442
>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
Length = 412
Score = 461 bits (1187), Expect = e-130
Identities = 228/410 (55%), Positives = 294/410 (71%), Gaps = 7/410 (1%)
Query: 6 LSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPP 65
L +L+ TV+LSLSTC+TLD +KR+EAIRGQILSKL+LTSPPE VP
Sbjct: 9 LVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEP-TVMTHVPY 67
Query: 66 EVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPPTFYRP 125
+V+++YNSTR+LL+E R C +E ++ EYYAKE++K DM N +
Sbjct: 68 QVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGI 127
Query: 126 YFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYI 185
++ RF+VS++EKN +NL +AEFRV R+ NP ++ EQRIEL+QIL+ + + QRYI
Sbjct: 128 TSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAK-QRYI 186
Query: 186 DSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEE 245
K + TR EWLSFDVTD V EWL ++ NLG +IS+HCPC TF P N I+ N E
Sbjct: 187 GGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQP-NGDILENIHEV 245
Query: 246 LEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQ-QTNRRKKRAL 304
+E +F G+D + GD +K K+ PHL+LM++P +RL++ Q +RKKRAL
Sbjct: 246 MEIKFKGVDNEDDHGRGDLGRLK---KQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRAL 302
Query: 305 DAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVL 364
D YCFRN+++NCC+RPLYIDF++DLGWKW+HEPKGY ANFC+G CPYL S+DT HS VL
Sbjct: 303 DTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVL 362
Query: 365 SLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS 414
LYNT+NPEASASPCCV QDLEPLTILYY+G+TPK+EQLSNM+VKSCKCS
Sbjct: 363 GLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 412
>gi|63025222 transforming growth factor, beta 1 [Homo sapiens]
Length = 390
Score = 313 bits (801), Expect = 2e-85
Identities = 183/402 (45%), Positives = 244/402 (60%), Gaps = 43/402 (10%)
Query: 18 ALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPP-EDYPEPEEVPPEVISIYNSTRD 76
A LSTC T+DM+ RKRIEAIRGQILSKL+L SPP + P +P V+++YNSTRD
Sbjct: 27 AAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRD 86
Query: 77 LLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSA 136
+ + +A E E + +YYAKEV ++ M + N I F + I F ++
Sbjct: 87 ----RVAGESAEPEPE-PEADYYAKEVTRVLM---VETHNEIYDKFKQSTHSIYMFFNTS 138
Query: 137 MEKNASN----LVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKT 192
+ A L +AE R+ RL K +V EQ +ELYQ ++ + RY+ ++++
Sbjct: 139 ELREAVPEPVLLSRAELRLLRL---KLKV-EQHVELYQ-----KYSNNSWRYLSNRLLAP 189
Query: 193 RAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAG 252
EWLSFDVT V +WL GF++S HC C ++ L+
Sbjct: 190 SDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSC-----------DSRDNTLQV---D 235
Query: 253 IDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRN 312
I+G +T GD TI + P LLLM P R + Q++R + RALD YCF +
Sbjct: 236 INGFTTGRRGDLATIHGMNR------PFLLLMATPLERAQHLQSSRHR-RALDTNYCFSS 288
Query: 313 VQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINP 372
+ NCC+R LYIDF++DLGWKWIHEPKGY+ANFC G CPY+WS DTQ+S+VL+LYN NP
Sbjct: 289 TEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNP 348
Query: 373 EASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS 414
ASA+PCCV Q LEPL I+YY+G+ PK+EQLSNMIV+SCKCS
Sbjct: 349 GASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS 390
>gi|4885259 myostatin [Homo sapiens]
Length = 375
Score = 102 bits (253), Expect = 8e-22
Identities = 94/387 (24%), Positives = 157/387 (40%), Gaps = 71/387 (18%)
Query: 36 RIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSD 95
RIEAI+ QILSKL+L + P ++V +++ R+L+ + +R + + D
Sbjct: 52 RIEAIKIQILSKLRLETAPNI---SKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLED 108
Query: 96 EEYYAKEVYKIDMPP---FFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF 152
++Y+A I MP F + P + + ++++ +VKA+ ++
Sbjct: 109 DDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYN---------KVVKAQLWIY 159
Query: 153 RLQNPKARVPEQRIELYQILKS-KDLTSPTQRYIDSKVVK---TRAEGEWLSFDVTDAVH 208
P +++ +++K KD T RY + +K G W S DV +
Sbjct: 160 L--RPVETPTTVFVQILRLIKPMKDGT----RYTGIRSLKLDMNPGTGIWQSIDVKTVLQ 213
Query: 209 EWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIK 268
WL + NLG +I + +L F G
Sbjct: 214 NWLKQPESNLGIEIKA--------------LDENGHDLAVTFPG---------------- 243
Query: 269 STRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKR 328
G P L ++ T +R +R + + CC PL +DF+
Sbjct: 244 ---PGEDGLNPFL--------EVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEA 292
Query: 329 DLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPL 388
GW WI PK Y AN+C+G C +++ H+ L + NP SA PCC + P+
Sbjct: 293 -FGWDWIIAPKRYKANYCSGECEFVFLQKYPHTH---LVHQANPRGSAGPCCTPTKMSPI 348
Query: 389 TILYYIGKTPKI-EQLSNMIVKSCKCS 414
+LY+ GK I ++ M+V C CS
Sbjct: 349 NMLYFNGKEQIIYGKIPAMVVDRCGCS 375
>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
Length = 431
Score = 101 bits (251), Expect = 1e-21
Identities = 84/304 (27%), Positives = 141/304 (46%), Gaps = 31/304 (10%)
Query: 122 FYRPYF--RIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQ--RIELYQILKSKDL 177
F+ P + R RFD+S + + + + AEFR+++ + R + RI +YQ+L+
Sbjct: 146 FFHPRYHHREFRFDLSKIPEGEA-VTAAEFRIYK-DYIRERFDNETFRISVYQVLQEHLG 203
Query: 178 TSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFV-PSNN 236
+DS+ + EG WL FD+T + W+ + NLG ++S+ + P
Sbjct: 204 RESDLFLLDSRTLWASEEG-WLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLA 262
Query: 237 YIIPNKSEELEARF--AGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQ 294
+I + + F A T + + T R +N KTP L + E+
Sbjct: 263 GLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENS 322
Query: 295 QTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYL 353
+++R+ C LY+ F RDLGW+ WI P+GY A +C G C +
Sbjct: 323 SSDQRQA---------------CKKHELYVSF-RDLGWQDWIIAPEGYAAYYCEGECAFP 366
Query: 354 WSS---DTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMIVK 409
+S T H+ V +L + INPE PCC L +++LY+ + I ++ NM+V+
Sbjct: 367 LNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVR 426
Query: 410 SCKC 413
+C C
Sbjct: 427 ACGC 430
>gi|5031613 growth differentiation factor 11 precursor [Homo
sapiens]
Length = 407
Score = 99.0 bits (245), Expect = 7e-21
Identities = 99/398 (24%), Positives = 149/398 (37%), Gaps = 84/398 (21%)
Query: 36 RIEAIRGQILSKLKLTSPPEDYPEP-----EEVPP--EVISIYNSTRDLLQEKASRRAAA 88
R+E+I+ QILSKL+L P E + PP +++ +++ D LQ
Sbjct: 75 RLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQP-------- 126
Query: 89 CERERSDEEYYAKEVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAE 148
E ++EY+A I M + T P F M + ++KA+
Sbjct: 127 -EDFLEEDEYHATTETVISMAQ---ETDPAVQTDGSPLCCHFHFSPKVM---FTKVLKAQ 179
Query: 149 FRVFRLQNPKARVPEQRIELYQILKSKDLTSPT--------QRYIDSKVVKTRAE---GE 197
V+ VP QIL+ K LT +R+I + +K G
Sbjct: 180 LWVYLRP-----VPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGH 234
Query: 198 WLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTS 257
W S D +H W N G +I+ P
Sbjct: 235 WQSIDFKQVLHSWFRQPQSNWGIEINAFDP------------------------------ 264
Query: 258 TYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNC 317
SG + S G P + L +L + +R +R L + + C
Sbjct: 265 ---SGTDLAVTSLGPGAEGLHPFMELRVL--------ENTKRSRRNLGLDCDEHSSESRC 313
Query: 318 CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASAS 377
C PL +DF+ GW WI PK Y AN+C+G C Y++ H+ L NP SA
Sbjct: 314 CRYPLTVDFEA-FGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTH---LVQQANPRGSAG 369
Query: 378 PCCVSQDLEPLTILYYIGKTPKI-EQLSNMIVKSCKCS 414
PCC + P+ +LY+ K I ++ M+V C CS
Sbjct: 370 PCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS 407
>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
sapiens]
Length = 513
Score = 92.8 bits (229), Expect = 5e-19
Identities = 69/270 (25%), Positives = 118/270 (43%), Gaps = 53/270 (19%)
Query: 166 IELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLH 225
I +YQ+L+ +D++VV EG WL FD+T + W+ N+G ++S
Sbjct: 274 ISIYQVLQEHQHRDSDLFLLDTRVVWASEEG-WLEFDITATSNLWVVTPQHNMGLQLS-- 330
Query: 226 CPCCTFVPSNNYIIPNKSEELEARFAGIDGTS----------TYTSGDQKTIKSTRKKNS 275
++ + R AG+ G + + +++TR +S
Sbjct: 331 ------------VVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASS 378
Query: 276 GKTPHLLLMLLPSYRLESQQTNRRKKRALDAA-------YCFRNVQDNCCLRPLYIDFKR 328
+ QQ+ R ++ D A Y ++ C LY+ F+
Sbjct: 379 RRR---------------QQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQ- 422
Query: 329 DLGWK-WIHEPKGYNANFCAGACPYLWSSD---TQHSRVLSLYNTINPEASASPCCVSQD 384
DLGW+ WI PKGY AN+C G C + ++ T H+ V +L + +NPE PCC
Sbjct: 423 DLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTK 482
Query: 385 LEPLTILYYIGKTPKI-EQLSNMIVKSCKC 413
L +++LY+ + I ++ NM+V++C C
Sbjct: 483 LNAISVLYFDDNSNVILKKYRNMVVRACGC 512
>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
sapiens]
Length = 396
Score = 89.0 bits (219), Expect = 7e-18
Identities = 77/283 (27%), Positives = 125/283 (44%), Gaps = 45/283 (15%)
Query: 144 LVKAEFRVFRLQNPKARVPEQ----RIELYQILKSKDLTS--PTQRYIDSKVVKTRAEGE 197
+ AE +VFR Q A RI +Y+I+K S P R +D+++V A
Sbjct: 145 ITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNAS-R 203
Query: 198 WLSFDVTDAVHEWLHHKDRNLGFKISL-HCPCCTFVPSNNYIIPNKSEELEARFAGIDGT 256
W SFDVT AV W N GF + + H V + I + E ++ I
Sbjct: 204 WESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPL 263
Query: 257 STYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDN 316
D K P ++ E +Q ++++ L + +
Sbjct: 264 LVTFGHDGKGH-------------------PLHKREKRQAKHKQRKRL---------KSS 295
Query: 317 CCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYLWS---SDTQHSRVLSLYNTINP 372
C PLY+DF D+GW WI P GY+A +C G CP+ + + T H+ V +L N++N
Sbjct: 296 CKRHPLYVDFS-DVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNS 354
Query: 373 EASASPCCVSQDLEPLTILYYIGKTPKI--EQLSNMIVKSCKC 413
+ + CCV +L +++L Y+ + K+ + +M+V+ C C
Sbjct: 355 KIPKA-CCVPTELSAISML-YLDENEKVVLKNYQDMVVEGCGC 395
>gi|4504699 inhibin beta A precursor [Homo sapiens]
Length = 426
Score = 88.2 bits (217), Expect = 1e-17
Identities = 84/312 (26%), Positives = 139/312 (44%), Gaps = 44/312 (14%)
Query: 128 RIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQR--IELYQILKSKDLTSPT---- 181
+ + F++S + S + +AE +F L+ PKA + I L+Q K + T
Sbjct: 134 KTLHFEISKEGSDLSVVERAEVWLF-LKVPKANRTRTKVTIRLFQQQKHPQGSLDTGEEA 192
Query: 182 ----------QRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTF 231
+ + KVV R + W F V+ ++ L +L +I+ C C
Sbjct: 193 EEVGLKGERSELLLSEKVVDAR-KSTWHVFPVSSSIQRLLDQGKSSLDVRIA--CEQCQE 249
Query: 232 VPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRL 291
++ ++ K ++ E +G G + + +K P L+L R
Sbjct: 250 SGASLVLLGKKKKKEE------EGEGKKKGGGEGGAGADEEKEQSHRPFLMLQA----RQ 299
Query: 292 ESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGAC 350
+RR++R L+ C V + CC + ++ FK D+GW WI P GY+AN+C G C
Sbjct: 300 SEDHPHRRRRRGLE---CDGKV-NICCKKQFFVSFK-DIGWNDWIIAPSGYHANYCEGEC 354
Query: 351 P-----YLWSSDTQHSRVLSLYNT--INPEASASPCCVSQDLEPLTILYY-IGKTPKIEQ 402
P SS + HS V++ Y +P A+ CCV L P+++LYY G+ +
Sbjct: 355 PSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKD 414
Query: 403 LSNMIVKSCKCS 414
+ NMIV+ C CS
Sbjct: 415 IQNMIVEECGCS 426
>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
sapiens]
Length = 424
Score = 87.8 bits (216), Expect = 2e-17
Identities = 97/409 (23%), Positives = 175/409 (42%), Gaps = 72/409 (17%)
Query: 37 IEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDE 96
+++++ + L L L+ P + P ++ +YN ++ S +A R +E
Sbjct: 55 LQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNK---FATDRTSMPSANIIRSFKNE 111
Query: 97 EYYAKEVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQN 156
+ +++ V S N + R Y + + E+ ++ AE R++ L
Sbjct: 112 DLFSQPV----------SFNGL-----RKYPLLFNVSIPHHEE----VIMAELRLYTLVQ 152
Query: 157 PKARV---PEQRIELYQILKSKDLTSPTQRY---IDSKVVKTRAEGEWLSFDVTDAVHEW 210
+ +++I ++++L+SK + + ++ T +E W +FDVTDA+ W
Sbjct: 153 RDRMIYDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSE--WETFDVTDAIRRW 210
Query: 211 LHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAG---IDGTSTYT------- 260
K + ++ +H I +K +E E +G ID ++
Sbjct: 211 --QKSGSSTHQLEVH-------------IESKHDEAEDASSGRLEIDTSAQNKHNPLLIV 255
Query: 261 -SGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALD---------AAYCF 310
S DQ + K +++ + H L L + L+S + ++ L A
Sbjct: 256 FSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIR 315
Query: 311 RNVQDNCCLR-PLYIDFKRDLGW-KWIHEPKGYNANFCAGACPYLWS---SDTQHSRVLS 365
RN + N C R PLYIDFK ++GW WI P GY A C G C Y + + T+H+ + +
Sbjct: 316 RNAKGNYCKRTPLYIDFK-EIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQA 374
Query: 366 LYNTINPEASASPCCVSQDLEPLTILYY-IGKTPKIEQLSNMIVKSCKC 413
L + N + ++ CCV LEP++ILY G + M V C C
Sbjct: 375 LVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC 423
>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
sapiens]
Length = 454
Score = 87.4 bits (215), Expect = 2e-17
Identities = 73/306 (23%), Positives = 130/306 (42%), Gaps = 42/306 (13%)
Query: 124 RPYFRIVRFDVSAMEKNASNLVKAEFRVFR-LQNPKARVPEQRIELYQILKSKDLTSPTQ 182
R +++ RFD++ + + + AEFR+++ N + +I +YQI+K
Sbjct: 174 RRHYKEFRFDLTQIPHGEA-VTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADL 232
Query: 183 RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNK 242
+D++ + G WL FD+T + W+ + NLG ++
Sbjct: 233 FLLDTRKAQALDVG-WLVFDITVTSNHWVINPQNNLGLQLCAET--------------GD 277
Query: 243 SEELEARFAGIDGTS----------TYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLE 292
+ + AG+ G + + ++S R N K + +
Sbjct: 278 GRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQN-------RNKSS 330
Query: 293 SQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACP 351
S Q + R D Y + C LY+ F RDLGW+ WI P+GY A +C G C
Sbjct: 331 SHQDSSRMSSVGD--YNTSEQKQACKKHELYVSF-RDLGWQDWIIAPEGYAAFYCDGECS 387
Query: 352 YLWSSD---TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMI 407
+ ++ T H+ V +L + + P+ PCC L +++LY+ + I ++ NM+
Sbjct: 388 FPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMV 447
Query: 408 VKSCKC 413
V+SC C
Sbjct: 448 VRSCGC 453
>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
sapiens]
Length = 402
Score = 87.0 bits (214), Expect = 3e-17
Identities = 75/298 (25%), Positives = 130/298 (43%), Gaps = 28/298 (9%)
Query: 125 PYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRY 184
P+++ RFD++ + + + AEFR++++ + + ++Q+++ + +
Sbjct: 123 PHWKEFRFDLTQIPAGEA-VTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLFF 181
Query: 185 IDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSE 244
+D + ++ EG WL DVT A WL + ++LG ++ Y+
Sbjct: 182 LDLQTLRAGDEG-WLVLDVTAASDCWLLKRHKDLGLRL--------------YVETEDGH 226
Query: 245 ELEARFAGIDGTSTYTSGDQKTIKSTRKKNSG-KTPHLLLMLL---PSYRLESQQTNRRK 300
++ AG+ G S + R S +TP + L P E Q NR
Sbjct: 227 SVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLP 286
Query: 301 KRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW-KWIHEPKGYNANFCAGACPYLWSS--- 356
D + Q C LY+ F+ DLGW W+ P+GY+A +C G C + S
Sbjct: 287 G-IFDDVHGSHGRQV-CRRHELYVSFQ-DLGWLDWVIAPQGYSAYYCEGECSFPLDSCMN 343
Query: 357 DTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMIVKSCKC 413
T H+ + SL + + P+A CC L ++LYY I + NM+VK+C C
Sbjct: 344 ATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
Length = 402
Score = 87.0 bits (214), Expect = 3e-17
Identities = 74/298 (24%), Positives = 129/298 (43%), Gaps = 28/298 (9%)
Query: 125 PYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRY 184
P+++ RFD++ + + + AEFR++++ + + ++Q+++ + +
Sbjct: 123 PHWKEFRFDLTQIPAGEA-VTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLFF 181
Query: 185 IDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSE 244
+D + ++ EG WL DVT A WL + ++LG ++ Y+
Sbjct: 182 LDLQTLRAGDEG-WLVLDVTAASDCWLLKRHKDLGLRL--------------YVETEDGH 226
Query: 245 ELEARFAGIDGTSTYTSGDQKTIKSTRKKNSG-KTPHLLLMLL---PSYRLESQQTNRRK 300
++ AG+ G S + R S +TP + L P E Q NR
Sbjct: 227 SVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLP 286
Query: 301 KRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW-KWIHEPKGYNANFCAGACPYLWSS--- 356
D + + C LY+ F+ DLGW W+ P+GY+A +C G C + S
Sbjct: 287 GIFDDVRGS--HGRQVCRRHELYVSFQ-DLGWLDWVIAPQGYSAYYCEGECSFPLDSCMN 343
Query: 357 DTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNMIVKSCKC 413
T H+ + SL + + P A CC L ++LYY I + NM+VK+C C
Sbjct: 344 ATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 84.7 bits (208), Expect = 1e-16
Identities = 80/309 (25%), Positives = 134/309 (43%), Gaps = 43/309 (13%)
Query: 118 IPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQ---NPKARVPEQRIELYQILKS 174
IP T FR + F++S++ +N + AE R+FR Q P RI +Y+++K
Sbjct: 129 IPGTSENSAFRFL-FNLSSIPENEV-ISSAELRLFREQVDQGPDWERGFHRINIYEVMKP 186
Query: 175 KDLTSPTQ---RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISL-HCPCCT 230
P R +D+++V W +FDV+ AV W K N G I + H
Sbjct: 187 PAEVVPGHLITRLLDTRLVHHNVT-RWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTR 245
Query: 231 FVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYR 290
+ I + +A + D + TR++ + ++P +
Sbjct: 246 THQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSP----------K 295
Query: 291 LESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGA 349
SQ+ ++ K NC LY+DF D+GW WI P GY A +C G
Sbjct: 296 HHSQRARKKNK--------------NCRRHSLYVDFS-DVGWNDWIVAPPGYQAFYCHGD 340
Query: 350 CPYLWS---SDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI--EQLS 404
CP+ + + T H+ V +L N++N + CCV +L +++L Y+ + K+ +
Sbjct: 341 CPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML-YLDEYDKVVLKNYQ 398
Query: 405 NMIVKSCKC 413
M+V+ C C
Sbjct: 399 EMVVEGCGC 407
>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 84.7 bits (208), Expect = 1e-16
Identities = 80/309 (25%), Positives = 134/309 (43%), Gaps = 43/309 (13%)
Query: 118 IPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQ---NPKARVPEQRIELYQILKS 174
IP T FR + F++S++ +N + AE R+FR Q P RI +Y+++K
Sbjct: 129 IPGTSENSAFRFL-FNLSSIPENEV-ISSAELRLFREQVDQGPDWERGFHRINIYEVMKP 186
Query: 175 KDLTSPTQ---RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISL-HCPCCT 230
P R +D+++V W +FDV+ AV W K N G I + H
Sbjct: 187 PAEVVPGHLITRLLDTRLVHHNVT-RWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTR 245
Query: 231 FVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYR 290
+ I + +A + D + TR++ + ++P +
Sbjct: 246 THQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSP----------K 295
Query: 291 LESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGA 349
SQ+ ++ K NC LY+DF D+GW WI P GY A +C G
Sbjct: 296 HHSQRARKKNK--------------NCRRHSLYVDFS-DVGWNDWIVAPPGYQAFYCHGD 340
Query: 350 CPYLWS---SDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI--EQLS 404
CP+ + + T H+ V +L N++N + CCV +L +++L Y+ + K+ +
Sbjct: 341 CPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML-YLDEYDKVVLKNYQ 398
Query: 405 NMIVKSCKC 413
M+V+ C C
Sbjct: 399 EMVVEGCGC 407
>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 84.7 bits (208), Expect = 1e-16
Identities = 80/309 (25%), Positives = 134/309 (43%), Gaps = 43/309 (13%)
Query: 118 IPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQ---NPKARVPEQRIELYQILKS 174
IP T FR + F++S++ +N + AE R+FR Q P RI +Y+++K
Sbjct: 129 IPGTSENSAFRFL-FNLSSIPENEV-ISSAELRLFREQVDQGPDWERGFHRINIYEVMKP 186
Query: 175 KDLTSPTQ---RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISL-HCPCCT 230
P R +D+++V W +FDV+ AV W K N G I + H
Sbjct: 187 PAEVVPGHLITRLLDTRLVHHNVT-RWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTR 245
Query: 231 FVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYR 290
+ I + +A + D + TR++ + ++P +
Sbjct: 246 THQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSP----------K 295
Query: 291 LESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGA 349
SQ+ ++ K NC LY+DF D+GW WI P GY A +C G
Sbjct: 296 HHSQRARKKNK--------------NCRRHSLYVDFS-DVGWNDWIVAPPGYQAFYCHGD 340
Query: 350 CPYLWS---SDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI--EQLS 404
CP+ + + T H+ V +L N++N + CCV +L +++L Y+ + K+ +
Sbjct: 341 CPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISML-YLDEYDKVVLKNYQ 398
Query: 405 NMIVKSCKC 413
M+V+ C C
Sbjct: 399 EMVVEGCGC 407
>gi|13899338 activin beta E [Homo sapiens]
Length = 350
Score = 74.7 bits (182), Expect = 1e-13
Identities = 42/106 (39%), Positives = 64/106 (60%), Gaps = 10/106 (9%)
Query: 317 CCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGAC-PYLWSSD----TQHSRVLSLYNTI 370
CC R Y+DF+ +LGW+ WI +P+GY N+C+G C P+L S + HS V SL
Sbjct: 247 CCRRDHYVDFQ-ELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKAN 305
Query: 371 NPEASASPCCVSQDLEPLTILY--YIGKTPKIEQLSNMIVKSCKCS 414
NP +++ CCV PL++LY + G K + + +M+V++C CS
Sbjct: 306 NPWPASTSCCVPTARRPLSLLYLDHNGNVVKTD-VPDMVVEACGCS 350
>gi|61835232 growth differentiation factor 7 preproprotein [Homo
sapiens]
Length = 450
Score = 72.8 bits (177), Expect = 5e-13
Identities = 80/315 (25%), Positives = 125/315 (39%), Gaps = 41/315 (13%)
Query: 132 FDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVK 191
FDVS++ +A +V AE RV R +P++ +L + + R + S+ +
Sbjct: 143 FDVSSLN-DADEVVGAELRVLRRGSPESGPGSWTSPPLLLLSTCPGAARAPRLLYSRAAE 201
Query: 192 TRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFA 251
W +FDV DA+ F + L VPS P L +
Sbjct: 202 PLVGQRWEAFDVADAMRRHRREPRPPRAFCLLLRAVAGP-VPS-----PLALRRLGFGWP 255
Query: 252 GIDGTSTYTSGDQKTIKSTRKKNS-----GKTPHLLLMLLPSYRLESQQTN--------- 297
G G++ T++K S L L S L T
Sbjct: 256 GGGGSAAEERAVLVVSSRTQRKESLFREIRAQARALGAALASEPLPDPGTGTASPRAVIG 315
Query: 298 --RRKKRALDAAYCF------------RNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYN 342
RR++ AL R + C +PL++DFK +LGW WI P Y
Sbjct: 316 GRRRRRTALAGTRTAQGSGGGAGRGHGRRGRSRCSRKPLHVDFK-ELGWDDWIIAPLDYE 374
Query: 343 ANFCAGACPYLWSSD---TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPK 399
A C G C + S T H+ + +L N++ P+A+ + CCV L P++ILY
Sbjct: 375 AYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNV 434
Query: 400 I-EQLSNMIVKSCKC 413
+ +Q +M+V++C C
Sbjct: 435 VYKQYEDMVVEACGC 449
>gi|48475062 growth differentiation factor 6 precursor [Homo
sapiens]
Length = 455
Score = 68.9 bits (167), Expect = 8e-12
Identities = 41/124 (33%), Positives = 68/124 (54%), Gaps = 9/124 (7%)
Query: 298 RRKKRALDAAYCFRNVQDN---CCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYL 353
RR++ A + + R+ + + C +PL+++FK +LGW WI P Y A C G C +
Sbjct: 332 RRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFK-ELGWDDWIIAPLEYEAYHCEGVCDFP 390
Query: 354 WSSD---TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYY-IGKTPKIEQLSNMIVK 409
S T H+ + +L N+++P ++ CCV L P++ILY G +Q +M+V+
Sbjct: 391 LRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVE 450
Query: 410 SCKC 413
SC C
Sbjct: 451 SCGC 454
>gi|4503969 growth differentiation factor 5 preproprotein [Homo
sapiens]
Length = 501
Score = 68.6 bits (166), Expect = 1e-11
Identities = 42/127 (33%), Positives = 69/127 (54%), Gaps = 10/127 (7%)
Query: 296 TNRRKKRALDAAYC----FRNVQDNCCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGAC 350
+ RRK+RA A +N++ C + L+++FK D+GW WI P Y A C G C
Sbjct: 375 SQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFK-DMGWDDWIIAPLEYEAFHCEGLC 433
Query: 351 PYLWSSD---TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSNM 406
+ S T H+ + +L N+++PE++ CCV L P++IL+ + +Q +M
Sbjct: 434 EFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDM 493
Query: 407 IVKSCKC 413
+V+SC C
Sbjct: 494 VVESCGC 500
>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
Length = 352
Score = 66.2 bits (160), Expect = 5e-11
Identities = 37/107 (34%), Positives = 59/107 (55%), Gaps = 10/107 (9%)
Query: 317 CCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACPYLWS-----SDTQHSRVLSLY--N 368
CC + ++DF R++GW WI +P+GY NFC G CP + + + H+ VL+L N
Sbjct: 247 CCRQEFFVDF-REIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKAN 305
Query: 369 TINPEASASPCCVSQDLEPLTILYYIGKTPKIE-QLSNMIVKSCKCS 414
T CCV PL++LYY + ++ + +M+V++C CS
Sbjct: 306 TAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGCS 352
>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
sapiens]
Length = 472
Score = 63.9 bits (154), Expect = 3e-10
Identities = 45/153 (29%), Positives = 73/153 (47%), Gaps = 19/153 (12%)
Query: 268 KSTRKKNSGKTPHLLLMLLPSYRLESQQTNR-RKKRALDAAYCFRNVQDNCCLRPLYIDF 326
KS KK K PH L + + Q + R+K+ ++ NC R L +DF
Sbjct: 331 KSKNKKKQRKGPHRKSQTL---QFDEQTLKKARRKQWIEPR--------NCARRYLKVDF 379
Query: 327 KRDLGW-KWIHEPKGYNANFCAGACPYLWSSD---TQHSRVLSLYNTIN-PEASASPCCV 381
D+GW +WI PK ++A +C+GAC + + H+ + S+ + PCCV
Sbjct: 380 A-DIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCV 438
Query: 382 SQDLEPLTILYY-IGKTPKIEQLSNMIVKSCKC 413
+ + L+IL++ K ++ NM V+SC C
Sbjct: 439 PEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471
>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
Length = 407
Score = 63.2 bits (152), Expect = 4e-10
Identities = 37/107 (34%), Positives = 62/107 (57%), Gaps = 11/107 (10%)
Query: 317 CCLRPLYIDFKRDLGWK-WIHEPKGYNANFCAGACP-YL----WSSDTQHSRVLSLYNT- 369
CC + +IDF R +GW WI P GY N+C G+CP YL S+ + H+ V++ Y
Sbjct: 303 CCRQQFFIDF-RLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMR 361
Query: 370 -INPEASASPCCVSQDLEPLTILYYIGKTPKIEQ-LSNMIVKSCKCS 414
+NP + + CC+ L +++LY+ + +++ + NMIV+ C C+
Sbjct: 362 GLNP-GTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGCA 407
>gi|153792495 growth differentiation factor 15 [Homo sapiens]
Length = 308
Score = 62.0 bits (149), Expect = 1e-09
Identities = 34/142 (23%), Positives = 61/142 (42%), Gaps = 7/142 (4%)
Query: 273 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW 332
++S P L L L P RR+ RA + +C C L + + DLGW
Sbjct: 172 ESSSARPQLELHLRPQ-----AARGRRRARARNGDHCPLGPGRCCRLHTVRASLE-DLGW 225
Query: 333 K-WIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTIL 391
W+ P+ C GACP + + H+++ + + + P+ +PCCV P+ ++
Sbjct: 226 ADWVLSPREVQVTMCIGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLI 285
Query: 392 YYIGKTPKIEQLSNMIVKSCKC 413
++ +++ K C C
Sbjct: 286 QKTDTGVSLQTYDDLLAKDCHC 307
>gi|239757187 PREDICTED: similar to growth differentiation factor 15
[Homo sapiens]
Length = 270
Score = 62.0 bits (149), Expect = 1e-09
Identities = 34/142 (23%), Positives = 61/142 (42%), Gaps = 7/142 (4%)
Query: 273 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW 332
++S P L L L P RR+ RA + +C C L + + DLGW
Sbjct: 134 ESSSARPQLELHLRPQ-----AARGRRRARARNGDHCPLGPGRCCRLHTVRASLE-DLGW 187
Query: 333 K-WIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTIL 391
W+ P+ C GACP + + H+++ + + + P+ +PCCV P+ ++
Sbjct: 188 ADWVLSPREVQVTMCIGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLI 247
Query: 392 YYIGKTPKIEQLSNMIVKSCKC 413
++ +++ K C C
Sbjct: 248 QKTDTGVSLQTYDDLLAKDCHC 269
>gi|110349792 growth differentiation factor 1 [Homo sapiens]
Length = 372
Score = 61.6 bits (148), Expect = 1e-09
Identities = 34/106 (32%), Positives = 55/106 (51%), Gaps = 10/106 (9%)
Query: 317 CCLRPLYIDFKRDLGW-KWIHEPKGYNANFCAGAC--PYLWSSD-----TQHSRVLSLYN 368
C R LY+ F R++GW +W+ P+G+ AN+C G C P S H+ + +L +
Sbjct: 267 CRARRLYVSF-REVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMH 325
Query: 369 TINPEASASPCCVSQDLEPLTILYYIGK-TPKIEQLSNMIVKSCKC 413
P A+ PCCV L P+++L++ + Q +M+V C C
Sbjct: 326 AAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371
>gi|10190670 growth differentiation factor 3 precursor [Homo
sapiens]
Length = 364
Score = 60.1 bits (144), Expect = 4e-09
Identities = 38/128 (29%), Positives = 65/128 (50%), Gaps = 7/128 (5%)
Query: 291 LESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW-KWIHEPKGYNANFCAGA 349
L Q + +KR + ++ C L+I+F RDLGW KWI PKG+ AN+C G
Sbjct: 238 LNPDQCHPSRKRRAAIPVPKLSCKNLCHRHQLFINF-RDLGWHKWIIAPKGFMANYCHGE 296
Query: 350 CPY---LWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI-EQLSN 405
CP+ + + + ++ + +L + ++PE + C+ L P+++LY I +
Sbjct: 297 CPFSLTISLNSSNYAFMQALMHAVDPEIPQA-VCIPTKLSPISMLYQDNNDNVILRHYED 355
Query: 406 MIVKSCKC 413
M+V C C
Sbjct: 356 MVVDECGC 363
>gi|7705308 growth differentiation factor 2 [Homo sapiens]
Length = 429
Score = 55.8 bits (133), Expect = 7e-08
Identities = 89/408 (21%), Positives = 160/408 (39%), Gaps = 69/408 (16%)
Query: 37 IEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDE 96
+E ++ L L L+ P E P +I +YN +K++ A+ R S E
Sbjct: 59 LENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNR---YTSDKSTTPASNIVRSFSME 115
Query: 97 EYYAKEVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF-RLQ 155
+ I FP + I+ F++S + +AE R++ Q
Sbjct: 116 D-----AISITATEDFPFQK-----------HILLFNISIPRHE--QITRAELRLYVSCQ 157
Query: 156 N--PKARVPEQRIELYQILKSKDL---TSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEW 210
N + + + +Y +L D + T+ ++ S+ ++ W + +V+ AV W
Sbjct: 158 NHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEG---WETLEVSSAVKRW 214
Query: 211 LHH---KDRN-LGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKT 266
+ K +N L + H C + + +P S L + ++ ++SG ++T
Sbjct: 215 VRSDSTKSKNKLEVTVESHRKGCDTLDIS---VPPGSRNLPFF---VVFSNDHSSGTKET 268
Query: 267 IKSTRKKNSGKTPHLLLMLLPSYRLESQQTNR---------------RKKRALDAAYCFR 311
R+ S + +L L E+ +++ R+KR+ A
Sbjct: 269 RLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAG---- 324
Query: 312 NVQDNCCLRPLYIDFKRDLGW-KWIHEPKGYNANFCAGACPYLWSSD---TQHSRVLSLY 367
+C L ++F+ D+GW WI PK Y A C G C + + D T+H+ V +L
Sbjct: 325 ---SHCQKTSLRVNFE-DIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLV 380
Query: 368 NTINPEASASPCCVSQDLEPLTILYY--IGKTPKIEQLSNMIVKSCKC 413
+ P CCV L P+++LY +G M V C C
Sbjct: 381 HLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428
>gi|222352098 nodal precursor [Homo sapiens]
Length = 347
Score = 55.5 bits (132), Expect = 9e-08
Identities = 32/94 (34%), Positives = 44/94 (46%), Gaps = 5/94 (5%)
Query: 324 IDFKRDLGW-KWIHEPKGYNANFCAGACPYLWSSD---TQHSRVLSLYNTINPEASASPC 379
+DF +GW WI PK YNA C G CP + T H+ + SL P S C
Sbjct: 254 VDFNL-IGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTC 312
Query: 380 CVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKC 413
C +PL++LY ++ +MIV+ C C
Sbjct: 313 CAPVKTKPLSMLYVDNGRVLLDHHKDMIVEECGC 346
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,226,553
Number of Sequences: 37866
Number of extensions: 726307
Number of successful extensions: 2258
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 2151
Number of HSP's gapped (non-prelim): 85
length of query: 414
length of database: 18,247,518
effective HSP length: 105
effective length of query: 309
effective length of database: 14,271,588
effective search space: 4409920692
effective search space used: 4409920692
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.