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Search of human proteins with 4507247
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4507247 SH3 and cysteine rich domain [Homo sapiens]
(402 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4507247 SH3 and cysteine rich domain [Homo sapiens] 825 0.0
gi|39752673 SH3 and cysteine rich domain 2 [Homo sapiens] 308 7e-84
gi|21450838 SH3 and cysteine rich domain 3 [Homo sapiens] 234 1e-61
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 67 3e-11
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 67 3e-11
gi|11321634 CD2-associated protein [Homo sapiens] 60 3e-09
gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens] 57 3e-08
gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens] 57 3e-08
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 56 5e-08
gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Ho... 56 5e-08
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens] 55 9e-08
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 55 9e-08
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 55 9e-08
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 55 9e-08
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 55 1e-07
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 54 2e-07
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 54 2e-07
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 54 2e-07
gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo ... 54 3e-07
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 54 3e-07
gi|188219625 signal transducing adaptor molecule 2 [Homo sapiens] 54 3e-07
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 54 3e-07
gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens] 54 3e-07
gi|227430338 SH3 domain containing, Ysc84-like 1 isoform 2 [Homo... 53 4e-07
gi|227430336 SH3 domain containing, Ysc84-like 1 isoform 1 [Homo... 53 4e-07
gi|5453976 protein kinase C, theta [Homo sapiens] 53 6e-07
gi|4885563 protein kinase C, epsilon [Homo sapiens] 52 9e-07
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 52 9e-07
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 52 9e-07
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 52 9e-07
>gi|4507247 SH3 and cysteine rich domain [Homo sapiens]
Length = 402
Score = 825 bits (2132), Expect = 0.0
Identities = 402/402 (100%), Positives = 402/402 (100%)
Query: 1 MIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNF 60
MIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNF
Sbjct: 1 MIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNF 60
Query: 61 FQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFQEYIFKKPTF 120
FQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFQEYIFKKPTF
Sbjct: 61 FQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFQEYIFKKPTF 120
Query: 121 CDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQ 180
CDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQ
Sbjct: 121 CDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQ 180
Query: 181 FGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEA 240
FGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEA
Sbjct: 181 FGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEA 240
Query: 241 NGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQE 300
NGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQE
Sbjct: 241 NGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQE 300
Query: 301 NEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKE 360
NEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKE
Sbjct: 301 NEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKE 360
Query: 361 QGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI 402
QGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI
Sbjct: 361 QGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI 402
>gi|39752673 SH3 and cysteine rich domain 2 [Homo sapiens]
Length = 411
Score = 308 bits (788), Expect = 7e-84
Identities = 189/406 (46%), Positives = 251/406 (61%), Gaps = 42/406 (10%)
Query: 27 SPASTSS--QESKLQKLKRSLSFKTKSLRSKSADNFFQRTNSEDMKLQAHMVAEISPSSS 84
SP T S QE+KLQ+ KRSLS KT LRSKS +NFF R+ SE ++ +P
Sbjct: 18 SPPGTVSALQETKLQRFKRSLSLKT-ILRSKSLENFFLRSGSELKCPTEVLLTPPTPLPP 76
Query: 85 PLPAP-----GSLTSTPAR-------AGLHPGGKAHAFQEYIFKKPTFCDVCNHMIVGTN 132
P P P G T +P+ A L P + H+FQE++FK+ + C++C+ +IVG N
Sbjct: 77 PSPPPTASDRGLATPSPSPCPVPRPLAALKPV-RLHSFQEHVFKRASPCELCHQLIVG-N 134
Query: 133 AKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQ---FGCIKEVMP 189
+K GLRCK CK+S+H C++ ++ Q+C GK FRR +SSPLL+HE KE P
Sbjct: 135 SKQGLRCKMCKVSVHLWCSEEISHQQCPGKTSTSFRRNFSSPLLVHEPPPVCATSKESPP 194
Query: 190 IACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEANG------- 242
KVDPVYETLR+GTSLA + S S S+SP R S S+ E+ E+ G
Sbjct: 195 TGDSGKVDPVYETLRYGTSLALMNRSSFS-STSESPTR-SLSERDELTEDGEGSIRSSEE 252
Query: 243 -PGGGYDLRKRSNSVFTYP---ENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVP 298
PG ++ VFT P E + + P + + + +L KD M +YVALYKF+P
Sbjct: 253 GPGDS------ASPVFTAPAESEGPGPEEKSPGQQLP-KATLRKDVGPMYSYVALYKFLP 305
Query: 299 QENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGC 358
QEN DL ++PGD I L++DSNEDWWKGKI DR+GFFPANFVQR++ E ++RC + F G
Sbjct: 306 QENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFSGN 365
Query: 359 KEQGQITLKENQIC--VSSEEEQDGFIRVLSGKKKGLIPLDVLENI 402
KEQG ++LKENQIC V ++ DGFIRV SGKK+GL+P+D L I
Sbjct: 366 KEQGYMSLKENQICVGVGRSKDADGFIRVSSGKKRGLVPVDALTEI 411
>gi|21450838 SH3 and cysteine rich domain 3 [Homo sapiens]
Length = 364
Score = 234 bits (597), Expect = 1e-61
Identities = 143/398 (35%), Positives = 209/398 (52%), Gaps = 49/398 (12%)
Query: 17 KEAVGAEQPPSPASTSSQESKLQKLKRSL---SFKTKSLRSKSADNFFQRTNSEDMKLQA 73
KE + + +P PA T ++S LQ+LK+ L S TK + + N E +
Sbjct: 4 KEVLESPKPSFPAET--RQSGLQRLKQLLRKGSTGTKEMELPPEP----QANGEAVGAGG 57
Query: 74 HMV--------AEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFQEYIFKKPTFCDVCN 125
+ E P P P L + K H F+++ FKKP FCDVC
Sbjct: 58 GPIYYIYEEEEEEEEEEEEPPPEPPKLVND----------KPHKFKDHFFKKPKFCDVCA 107
Query: 126 HMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQFGCIK 185
MIV N K GLRCK CK +IH C + QRC GK+P GF R YSSPL ++Q+ C+K
Sbjct: 108 RMIV-LNNKFGLRCKNCKTNIHEHCQSYVEMQRCFGKIPPGFHRAYSSPLYSNQQYACVK 166
Query: 186 EVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEANGPGG 245
+ ++ N+ DPV+ETLR G +A + +K G + + E PE A G
Sbjct: 167 D---LSAANRNDPVFETLRTGVIMANKERK----KGQADKKNPVAAMMEEEPESARPEEG 219
Query: 246 GYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTY-VALYKFVPQENEDL 304
P++G + A+ + Q + Y VALY+F E +DL
Sbjct: 220 K-------------PQDGNPEGDKKAEKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDL 266
Query: 305 EMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKEQGQI 364
+ PG+ IT+++DSNE+WW+GKI +++GFFP NF+ R++ E++ R R+F+G +E GQI
Sbjct: 267 DFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSFVGNREIGQI 326
Query: 365 TLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI 402
TLK++QI V +E G+++V +G+K GL P D LE I
Sbjct: 327 TLKKDQIVVQKGDEAGGYVKVYTGRKVGLFPTDFLEEI 364
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 67.0 bits (162), Expect = 3e-11
Identities = 35/104 (33%), Positives = 59/104 (56%), Gaps = 4/104 (3%)
Query: 268 RDPAKNINHQGSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKI 327
R+ A++ Q + + D +ALY + + ++ M+ GDI+TLL +N+DWWK ++
Sbjct: 950 REQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEV 1009
Query: 328 QDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKEQGQITLKENQI 371
DR GF PA +V++L + R + +EQG I L++ QI
Sbjct: 1010 NDRQGFVPAAYVKKLDPAQSASR--ENLL--EEQGSIALRQEQI 1049
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 67.0 bits (162), Expect = 3e-11
Identities = 35/104 (33%), Positives = 59/104 (56%), Gaps = 4/104 (3%)
Query: 268 RDPAKNINHQGSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKI 327
R+ A++ Q + + D +ALY + + ++ M+ GDI+TLL +N+DWWK ++
Sbjct: 950 REQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEV 1009
Query: 328 QDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKEQGQITLKENQI 371
DR GF PA +V++L + R + +EQG I L++ QI
Sbjct: 1010 NDRQGFVPAAYVKKLDPAQSASR--ENLL--EEQGSIALRQEQI 1049
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 60.5 bits (145), Expect = 3e-09
Identities = 21/51 (41%), Positives = 38/51 (74%)
Query: 293 LYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQ 343
L++++PQ ++LE++ GDII + E+ E WW G + +++G FP+NFV+ L+
Sbjct: 116 LFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELE 166
Score = 39.3 bits (90), Expect = 0.006
Identities = 17/59 (28%), Positives = 32/59 (54%), Gaps = 2/59 (3%)
Query: 293 LYKFVPQENEDLEMRPGDIITLL--EDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIF 349
L+ + ++L + G+II L+ E WW+G++ + G FP NF ++ + +K F
Sbjct: 277 LFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKDF 335
Score = 38.1 bits (87), Expect = 0.014
Identities = 18/59 (30%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 287 MNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWW-KGKIQDRIGFFPANFVQRLQQ 344
M Y+ Y + +++L +R G+II ++ E+ W +G++ R G FP NFV+ +++
Sbjct: 1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKR 59
>gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens]
Length = 540
Score = 57.0 bits (136), Expect = 3e-08
Identities = 23/48 (47%), Positives = 34/48 (70%)
Query: 292 ALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFV 339
A+Y F E+ +L + G+IIT+L+DS+ +WWKG+ IG FP+NFV
Sbjct: 217 AIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
>gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens]
Length = 352
Score = 57.0 bits (136), Expect = 3e-08
Identities = 29/81 (35%), Positives = 44/81 (54%), Gaps = 2/81 (2%)
Query: 264 TDDFRDPAKNINHQGSLSKDPLQMNTYV--ALYKFVPQENEDLEMRPGDIITLLEDSNED 321
T D P ++H G+ +QM+ ALY F P+ +L + GDIITL +E+
Sbjct: 267 TGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDEN 326
Query: 322 WWKGKIQDRIGFFPANFVQRL 342
W++G + GFFP N+V+ L
Sbjct: 327 WYEGMLHGHSGFFPINYVEIL 347
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 56.2 bits (134), Expect = 5e-08
Identities = 26/61 (42%), Positives = 39/61 (63%), Gaps = 1/61 (1%)
Query: 286 QMNTYV-ALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQ 344
Q TYV AL+ F PQE+ +L R GD I ++++S+ +WWKG + G FP N+V + +
Sbjct: 156 QQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNR 215
Query: 345 N 345
N
Sbjct: 216 N 216
Score = 40.0 bits (92), Expect = 0.004
Identities = 15/51 (29%), Positives = 33/51 (64%), Gaps = 1/51 (1%)
Query: 291 VALYKFVPQENEDLEMRPGDIITLL-EDSNEDWWKGKIQDRIGFFPANFVQ 340
+A Y F +++L + GDI+ +L E+ +++W+K ++ + GF P N+++
Sbjct: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIE 54
>gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Homo
sapiens]
Length = 176
Score = 56.2 bits (134), Expect = 5e-08
Identities = 26/61 (42%), Positives = 39/61 (63%), Gaps = 1/61 (1%)
Query: 286 QMNTYV-ALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQ 344
Q TYV AL+ F PQE+ +L R GD I ++++S+ +WWKG + G FP N+V + +
Sbjct: 115 QQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNR 174
Query: 345 N 345
N
Sbjct: 175 N 175
Score = 40.0 bits (92), Expect = 0.004
Identities = 15/51 (29%), Positives = 33/51 (64%), Gaps = 1/51 (1%)
Query: 291 VALYKFVPQENEDLEMRPGDIITLL-EDSNEDWWKGKIQDRIGFFPANFVQ 340
+A Y F +++L + GDI+ +L E+ +++W+K ++ + GF P N+++
Sbjct: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIE 54
>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
Length = 2419
Score = 55.5 bits (132), Expect = 9e-08
Identities = 30/81 (37%), Positives = 45/81 (55%), Gaps = 3/81 (3%)
Query: 291 VALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFR 350
+ALY F + ++ M+ GD++TLL N+DWWK + D G PA +V+RL +E
Sbjct: 983 MALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPML 1042
Query: 351 CVRTFIGCKEQGQITLKENQI 371
R +E G IT ++ QI
Sbjct: 1043 PQRR---REEPGNITQRQEQI 1060
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 55.5 bits (132), Expect = 9e-08
Identities = 35/129 (27%), Positives = 66/129 (51%), Gaps = 18/129 (13%)
Query: 291 VALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRL-------- 342
V L+ F ++ +DL + G+I+ LLE + DW++G +++IG FPAN+V+ +
Sbjct: 442 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 501
Query: 343 -------QQNEKIFRCVRTF--IGCKEQGQITLKENQICVSSEEEQDGFIRVLSGKKKGL 393
K RCV F IG +++ +++ E +I + E + + R + G+
Sbjct: 502 GKRECVSSHCVKGSRCVARFEYIG-EQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGI 560
Query: 394 IPLDVLENI 402
PL+ +E +
Sbjct: 561 FPLNFVEPV 569
Score = 52.0 bits (123), Expect = 9e-07
Identities = 32/119 (26%), Positives = 56/119 (47%), Gaps = 11/119 (9%)
Query: 292 ALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIF-- 349
AL+ F + ++DL + GD I +LE + DW +G++QDR G FPA FV+ K
Sbjct: 609 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLA 668
Query: 350 --------RCVRTFIGCKEQGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLE 400
+ + F G + + +++ K I E D ++ K G+ P + ++
Sbjct: 669 IVPKGRKAKALYDFRG-ENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQ 726
Score = 52.0 bits (123), Expect = 9e-07
Identities = 22/52 (42%), Positives = 33/52 (63%)
Query: 292 ALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQ 343
ALY F + ++L + GDIIT LE ++DW G++ + G FP N++Q LQ
Sbjct: 678 ALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQ 729
Score = 48.9 bits (115), Expect = 8e-06
Identities = 19/53 (35%), Positives = 36/53 (67%)
Query: 291 VALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQ 343
VA ++++ ++ ++L G+II L E NE+W +G+++ R G FP NFV+ ++
Sbjct: 518 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVE 570
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 55.5 bits (132), Expect = 9e-08
Identities = 35/129 (27%), Positives = 66/129 (51%), Gaps = 18/129 (13%)
Query: 291 VALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRL-------- 342
V L+ F ++ +DL + G+I+ LLE + DW++G +++IG FPAN+V+ +
Sbjct: 478 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 537
Query: 343 -------QQNEKIFRCVRTF--IGCKEQGQITLKENQICVSSEEEQDGFIRVLSGKKKGL 393
K RCV F IG +++ +++ E +I + E + + R + G+
Sbjct: 538 GKRECVSSHCVKGSRCVARFEYIG-EQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGI 596
Query: 394 IPLDVLENI 402
PL+ +E +
Sbjct: 597 FPLNFVEPV 605
Score = 52.0 bits (123), Expect = 9e-07
Identities = 32/119 (26%), Positives = 56/119 (47%), Gaps = 11/119 (9%)
Query: 292 ALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIF-- 349
AL+ F + ++DL + GD I +LE + DW +G++QDR G FPA FV+ K
Sbjct: 645 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLA 704
Query: 350 --------RCVRTFIGCKEQGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLE 400
+ + F G + + +++ K I E D ++ K G+ P + ++
Sbjct: 705 IVPKGRKAKALYDFRG-ENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQ 762
Score = 52.0 bits (123), Expect = 9e-07
Identities = 22/52 (42%), Positives = 33/52 (63%)
Query: 292 ALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQ 343
ALY F + ++L + GDIIT LE ++DW G++ + G FP N++Q LQ
Sbjct: 714 ALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQ 765
Score = 48.9 bits (115), Expect = 8e-06
Identities = 19/53 (35%), Positives = 36/53 (67%)
Query: 291 VALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQ 343
VA ++++ ++ ++L G+II L E NE+W +G+++ R G FP NFV+ ++
Sbjct: 554 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVE 606
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 55.5 bits (132), Expect = 9e-08
Identities = 35/129 (27%), Positives = 66/129 (51%), Gaps = 18/129 (13%)
Query: 291 VALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRL-------- 342
V L+ F ++ +DL + G+I+ LLE + DW++G +++IG FPAN+V+ +
Sbjct: 501 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 560
Query: 343 -------QQNEKIFRCVRTF--IGCKEQGQITLKENQICVSSEEEQDGFIRVLSGKKKGL 393
K RCV F IG +++ +++ E +I + E + + R + G+
Sbjct: 561 GKRECVSSHCVKGSRCVARFEYIG-EQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGI 619
Query: 394 IPLDVLENI 402
PL+ +E +
Sbjct: 620 FPLNFVEPV 628
Score = 52.0 bits (123), Expect = 9e-07
Identities = 32/119 (26%), Positives = 56/119 (47%), Gaps = 11/119 (9%)
Query: 292 ALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIF-- 349
AL+ F + ++DL + GD I +LE + DW +G++QDR G FPA FV+ K
Sbjct: 668 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLA 727
Query: 350 --------RCVRTFIGCKEQGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLE 400
+ + F G + + +++ K I E D ++ K G+ P + ++
Sbjct: 728 IVPKGRKAKALYDFRG-ENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQ 785
Score = 52.0 bits (123), Expect = 9e-07
Identities = 22/52 (42%), Positives = 33/52 (63%)
Query: 292 ALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQ 343
ALY F + ++L + GDIIT LE ++DW G++ + G FP N++Q LQ
Sbjct: 737 ALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQ 788
Score = 48.9 bits (115), Expect = 8e-06
Identities = 19/53 (35%), Positives = 36/53 (67%)
Query: 291 VALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQ 343
VA ++++ ++ ++L G+II L E NE+W +G+++ R G FP NFV+ ++
Sbjct: 577 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVE 629
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 54.7 bits (130), Expect = 1e-07
Identities = 24/56 (42%), Positives = 40/56 (71%), Gaps = 1/56 (1%)
Query: 292 ALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQ-RLQQNE 346
AL+ V ++++L + GD+I +LE SN+DWW G+ +D+ +FPA+FV+ R+ Q E
Sbjct: 154 ALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEE 209
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 54.3 bits (129), Expect = 2e-07
Identities = 25/56 (44%), Positives = 38/56 (67%), Gaps = 1/56 (1%)
Query: 292 ALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEK 347
A++ V N +L + GD+I +L+ SN+DWW G+I D G+FPA+FV RL N++
Sbjct: 15 AVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFV-RLWVNQE 69
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/123 (28%), Positives = 64/123 (52%), Gaps = 15/123 (12%)
Query: 237 PEEANG---PGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYV-- 291
PE G P G D ++ V + E+ DD + + +H G + L +N +
Sbjct: 136 PEHTPGTAMPDGALDTAVCADEVGS-EEDLYDDLHSSSHHYSHPGG-GGEQLAINELISD 193
Query: 292 -------ALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQ-RLQ 343
AL+ V ++++L + GD+I +++ +N +WW G++ D G+FPA+FV+ R+
Sbjct: 194 GSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVN 253
Query: 344 QNE 346
Q+E
Sbjct: 254 QDE 256
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/123 (28%), Positives = 64/123 (52%), Gaps = 15/123 (12%)
Query: 237 PEEANG---PGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYV-- 291
PE G P G D ++ V + E+ DD + + +H G + L +N +
Sbjct: 136 PEHTPGTAMPDGALDTAVCADEVGS-EEDLYDDLHSSSHHYSHPGG-GGEQLAINELISD 193
Query: 292 -------ALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQ-RLQ 343
AL+ V ++++L + GD+I +++ +N +WW G++ D G+FPA+FV+ R+
Sbjct: 194 GSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVN 253
Query: 344 QNE 346
Q+E
Sbjct: 254 QDE 256
>gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo
sapiens]
Length = 628
Score = 53.5 bits (127), Expect = 3e-07
Identities = 18/49 (36%), Positives = 35/49 (71%)
Query: 294 YKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRL 342
+ ++PQ +++LE++ GDII ++ + E WW+G + + G FP+NF++ L
Sbjct: 70 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKEL 118
Score = 44.3 bits (103), Expect = 2e-04
Identities = 19/52 (36%), Positives = 33/52 (63%), Gaps = 2/52 (3%)
Query: 293 LYKFVPQENEDLEMRPGDIITLLEDSNED--WWKGKIQDRIGFFPANFVQRL 342
++ + Q +++L ++ GDI+TL+ D WW+G++ R G FP NFV+ L
Sbjct: 238 IFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLL 289
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 53.5 bits (127), Expect = 3e-07
Identities = 18/49 (36%), Positives = 35/49 (71%)
Query: 294 YKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRL 342
+ ++PQ +++LE++ GDII ++ + E WW+G + + G FP+NF++ L
Sbjct: 107 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKEL 155
Score = 45.4 bits (106), Expect = 9e-05
Identities = 18/54 (33%), Positives = 33/54 (61%)
Query: 294 YKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEK 347
+ + Q +++L + G+IIT + + WW+G+I R G FP NFV+ +++ K
Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMK 61
Score = 44.3 bits (103), Expect = 2e-04
Identities = 19/52 (36%), Positives = 33/52 (63%), Gaps = 2/52 (3%)
Query: 293 LYKFVPQENEDLEMRPGDIITLLEDSNED--WWKGKIQDRIGFFPANFVQRL 342
++ + Q +++L ++ GDI+TL+ D WW+G++ R G FP NFV+ L
Sbjct: 275 IFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLL 326
>gi|188219625 signal transducing adaptor molecule 2 [Homo sapiens]
Length = 525
Score = 53.5 bits (127), Expect = 3e-07
Identities = 26/60 (43%), Positives = 38/60 (63%), Gaps = 5/60 (8%)
Query: 285 LQMNTYVA-----LYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFV 339
+Q+N VA LY F E+ +L + G+II +L+DS+ +WWKG+ IG FP+NFV
Sbjct: 197 IQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
Length = 330
Score = 53.5 bits (127), Expect = 3e-07
Identities = 19/48 (39%), Positives = 33/48 (68%)
Query: 292 ALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFV 339
ALY F E+++L G+++ +L+ SN WW G++ +++G FPAN+V
Sbjct: 278 ALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYV 325
Score = 35.8 bits (81), Expect = 0.070
Identities = 14/49 (28%), Positives = 28/49 (57%), Gaps = 1/49 (2%)
Query: 291 VALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFV 339
VA + F ++L GD++ +L + E+W+K ++ + G+ P NF+
Sbjct: 4 VAKFDFTASGEDELSFHTGDVLKILSNQ-EEWFKAELGSQEGYVPKNFI 51
>gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens]
Length = 368
Score = 53.5 bits (127), Expect = 3e-07
Identities = 43/136 (31%), Positives = 66/136 (48%), Gaps = 14/136 (10%)
Query: 209 LAQRTKKGSSGSGSD-SPHRTSTSDLVEVPEEANGPGGGYDLRKRSNSVFTYPE-NGTDD 266
L +R ++ SS + P DL E PE++NG G+ T P+ +
Sbjct: 240 LKRRMREASSRPKREYKPKPREPFDLGE-PEQSNG---GFPCT-------TAPKIAASSS 288
Query: 267 FRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGK 326
FR K I S S PL + ALY F P+ + +L GD+ITL +E+W++G
Sbjct: 289 FRSSDKPIRTP-SRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGM 347
Query: 327 IQDRIGFFPANFVQRL 342
+ + GFFP ++V+ L
Sbjct: 348 LDGQSGFFPLSYVEVL 363
>gi|227430338 SH3 domain containing, Ysc84-like 1 isoform 2 [Homo
sapiens]
Length = 323
Score = 53.1 bits (126), Expect = 4e-07
Identities = 37/128 (28%), Positives = 56/128 (43%), Gaps = 11/128 (8%)
Query: 223 DSPHRTSTSDLVEV----PEEANGPGGGYDLRK-----RSNSVFTYPENGTDDFRDPAKN 273
D+P DL E+ E+ G + RK R +S P + +
Sbjct: 193 DTPRPAQAEDLYEILDSFTEKYENEGQRINARKAAREQRKSSAKELPPKPLSRPQQSSAP 252
Query: 274 INHQGSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIITLLE--DSNEDWWKGKIQDRI 331
+ + Q ALY F Q+ DL + GD IT++ DS+ DWW+GK++ +
Sbjct: 253 VQLNSGSQSNLNQPIEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGQT 312
Query: 332 GFFPANFV 339
G FPAN+V
Sbjct: 313 GIFPANYV 320
>gi|227430336 SH3 domain containing, Ysc84-like 1 isoform 1 [Homo
sapiens]
Length = 342
Score = 53.1 bits (126), Expect = 4e-07
Identities = 31/88 (35%), Positives = 47/88 (53%), Gaps = 14/88 (15%)
Query: 254 NSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIIT 313
N YP G + + N+N P+++ ALY F Q+ DL + GD IT
Sbjct: 264 NEYKLYP--GLSSYHERVGNLNQ-------PIEVT---ALYSFEGQQPGDLNFQAGDRIT 311
Query: 314 LLE--DSNEDWWKGKIQDRIGFFPANFV 339
++ DS+ DWW+GK++ + G FPAN+V
Sbjct: 312 VISKTDSHFDWWEGKLRGQTGIFPANYV 339
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 52.8 bits (125), Expect = 6e-07
Identities = 21/48 (43%), Positives = 32/48 (66%), Gaps = 1/48 (2%)
Query: 108 HAFQEYIFKKPTFCDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLA 155
H F+ Y +K PTFC+ C ++ G A+ GL+C AC M++HH+C +A
Sbjct: 232 HRFKVYNYKSPTFCEHCGTLLWGL-ARQGLKCDACGMNVHHRCQTKVA 278
Score = 51.2 bits (121), Expect = 2e-06
Identities = 23/56 (41%), Positives = 31/56 (55%), Gaps = 2/56 (3%)
Query: 106 KAHAFQEYIFKKPTFCDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMG 161
K H F F +PTFC VC+ + G N K G +C+ C +IH KC D + +C G
Sbjct: 158 KCHEFTATFFPQPTFCSVCHEFVWGLN-KQGYQCRQCNAAIHKKCIDKVI-AKCTG 211
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 52.0 bits (123), Expect = 9e-07
Identities = 21/49 (42%), Positives = 31/49 (63%), Gaps = 1/49 (2%)
Query: 108 HAFQEYIFKKPTFCDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAP 156
H F + +K PTFCD C ++ G + GL+CK CKM++H +C +AP
Sbjct: 243 HKFGIHNYKVPTFCDHCGSLLWGL-LRQGLQCKVCKMNVHRRCETNVAP 290
Score = 41.2 bits (95), Expect = 0.002
Identities = 17/54 (31%), Positives = 26/54 (48%), Gaps = 1/54 (1%)
Query: 108 HAFQEYIFKKPTFCDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMG 161
H F ++PT+C C I G K G +C+ C +H +C + L +C G
Sbjct: 170 HKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHE-LIITKCAG 222
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 52.0 bits (123), Expect = 9e-07
Identities = 17/50 (34%), Positives = 32/50 (64%)
Query: 291 VALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQ 340
+ +Y + Q +++L G II +L + DWWKG++ ++G FP+N+V+
Sbjct: 1161 IGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK 1210
Score = 48.9 bits (115), Expect = 8e-06
Identities = 22/57 (38%), Positives = 36/57 (63%), Gaps = 2/57 (3%)
Query: 290 YVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNE 346
++A+Y + E DL + GD+I L+ + DWW G + D+ G FP+N+V RL+ +E
Sbjct: 1007 FIAMYTYESSEQGDLTFQQGDVI-LVTKKDGDWWTGTVGDKAGVFPSNYV-RLKDSE 1061
Score = 44.3 bits (103), Expect = 2e-04
Identities = 18/64 (28%), Positives = 38/64 (59%), Gaps = 7/64 (10%)
Query: 290 YVALYKFVPQENEDLEMRPGDIITLL-------EDSNEDWWKGKIQDRIGFFPANFVQRL 342
Y ALY F + ++++ ++PGDI+ + + W G+++ + G+FPAN+ +++
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKI 804
Query: 343 QQNE 346
+NE
Sbjct: 805 PENE 808
Score = 41.6 bits (96), Expect = 0.001
Identities = 25/70 (35%), Positives = 39/70 (55%), Gaps = 8/70 (11%)
Query: 278 GSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDR-----IG 332
GSL K P ++ +A Y E L + PG +I + + + WW+G++Q R IG
Sbjct: 1070 GSLGKKP-EIAQVIASYTATGPEQ--LTLAPGQLILIRKKNPGGWWEGELQARGKKRQIG 1126
Query: 333 FFPANFVQRL 342
+FPAN+V+ L
Sbjct: 1127 WFPANYVKLL 1136
Score = 39.3 bits (90), Expect = 0.006
Identities = 17/49 (34%), Positives = 31/49 (63%), Gaps = 1/49 (2%)
Query: 292 ALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQ 340
ALY + +++ L D+IT+LE + WW G++Q + G+FP ++V+
Sbjct: 920 ALYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVK 967
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 52.0 bits (123), Expect = 9e-07
Identities = 17/50 (34%), Positives = 32/50 (64%)
Query: 291 VALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQ 340
+ +Y + Q +++L G II +L + DWWKG++ ++G FP+N+V+
Sbjct: 1161 IGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK 1210
Score = 48.9 bits (115), Expect = 8e-06
Identities = 22/57 (38%), Positives = 36/57 (63%), Gaps = 2/57 (3%)
Query: 290 YVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNE 346
++A+Y + E DL + GD+I L+ + DWW G + D+ G FP+N+V RL+ +E
Sbjct: 1007 FIAMYTYESSEQGDLTFQQGDVI-LVTKKDGDWWTGTVGDKAGVFPSNYV-RLKDSE 1061
Score = 44.3 bits (103), Expect = 2e-04
Identities = 18/64 (28%), Positives = 38/64 (59%), Gaps = 7/64 (10%)
Query: 290 YVALYKFVPQENEDLEMRPGDIITLL-------EDSNEDWWKGKIQDRIGFFPANFVQRL 342
Y ALY F + ++++ ++PGDI+ + + W G+++ + G+FPAN+ +++
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKI 804
Query: 343 QQNE 346
+NE
Sbjct: 805 PENE 808
Score = 41.6 bits (96), Expect = 0.001
Identities = 25/70 (35%), Positives = 39/70 (55%), Gaps = 8/70 (11%)
Query: 278 GSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDR-----IG 332
GSL K P ++ +A Y E L + PG +I + + + WW+G++Q R IG
Sbjct: 1070 GSLGKKP-EIAQVIASYTATGPEQ--LTLAPGQLILIRKKNPGGWWEGELQARGKKRQIG 1126
Query: 333 FFPANFVQRL 342
+FPAN+V+ L
Sbjct: 1127 WFPANYVKLL 1136
Score = 39.3 bits (90), Expect = 0.006
Identities = 17/49 (34%), Positives = 31/49 (63%), Gaps = 1/49 (2%)
Query: 292 ALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQ 340
ALY + +++ L D+IT+LE + WW G++Q + G+FP ++V+
Sbjct: 920 ALYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVK 967
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 52.0 bits (123), Expect = 9e-07
Identities = 58/245 (23%), Positives = 97/245 (39%), Gaps = 20/245 (8%)
Query: 168 RRYYSSPLLIHEQFGCIKEVMPIACGNKVDPVYETL-RFGTSLAQRTKKGSSGSGSDSPH 226
RR S + + C + + + CG P L R + QR + G+S GS P
Sbjct: 79 RRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDGIRQRPRAGTSPGGS--PP 136
Query: 227 RTSTSDLVEVPEEANGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQ 286
P A G GGG + VF G+ + +K+P
Sbjct: 137 ARPIPGQSAAPTLAGG-GGGAAGSTPGSPVFLSAAAGSTAGSLRELATSRTAPAAKNPCL 195
Query: 287 MNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQ--- 343
+ ALY + +E DL+ GDII L +E W+ G++ GF PA+++Q +Q
Sbjct: 196 LPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLP 255
Query: 344 ----QNEKIFRCVRTFIGCKEQGQ----ITLKENQICVSSEEEQDGFIRVLSGKKKGLIP 395
Q + ++ K++ Q +T +++I + + + G K G+ P
Sbjct: 256 HAPPQGKALYD-----FEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFP 310
Query: 396 LDVLE 400
L +E
Sbjct: 311 LLYVE 315
Score = 50.8 bits (120), Expect = 2e-06
Identities = 24/65 (36%), Positives = 42/65 (64%), Gaps = 2/65 (3%)
Query: 277 QGSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKG-KIQDRI-GFF 334
QG+ K L +N Y+ALY + PQ++++LE+ G++ +LE + W+KG ++ + G F
Sbjct: 456 QGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVF 515
Query: 335 PANFV 339
P N+V
Sbjct: 516 PGNYV 520
Score = 41.6 bits (96), Expect = 0.001
Identities = 18/58 (31%), Positives = 32/58 (55%), Gaps = 2/58 (3%)
Query: 285 LQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQ--DRIGFFPANFVQ 340
L Y + + PQ ++E++ GDI+ + + + W+KG +Q R G FP +FV+
Sbjct: 823 LPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,868,178
Number of Sequences: 37866
Number of extensions: 911252
Number of successful extensions: 4870
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 217
Number of HSP's successfully gapped in prelim test: 160
Number of HSP's that attempted gapping in prelim test: 4287
Number of HSP's gapped (non-prelim): 601
length of query: 402
length of database: 18,247,518
effective HSP length: 105
effective length of query: 297
effective length of database: 14,271,588
effective search space: 4238661636
effective search space used: 4238661636
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.