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Search of human proteins with 4505221
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505221 matrix metalloproteinase 8 preproprotein [Homo
sapiens]
(467 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens] 972 0.0
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H... 561 e-160
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens] 525 e-149
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens] 501 e-142
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens] 477 e-134
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens] 473 e-133
gi|73808268 matrix metalloproteinase 27 [Homo sapiens] 449 e-126
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi... 442 e-124
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi... 423 e-118
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens] 316 3e-86
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ... 311 8e-85
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens] 303 3e-82
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens] 291 7e-79
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein... 244 1e-64
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap... 237 1e-62
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens] 236 4e-62
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi... 233 2e-61
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi... 226 3e-59
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens] 212 7e-55
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [... 212 7e-55
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi... 187 2e-47
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot... 183 3e-46
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ... 172 6e-43
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens] 142 6e-34
gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi... 130 3e-30
gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens] 108 1e-23
gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens] 104 2e-22
gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens] 96 7e-20
gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens] 96 9e-20
gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ... 68 2e-11
>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
Length = 467
Score = 973 bits (2514), Expect = 0.0
Identities = 467/467 (100%), Positives = 467/467 (100%)
Query: 1 MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV 60
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
Sbjct: 1 MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV 60
Query: 61 EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY 120
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
Sbjct: 61 EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY 120
Query: 121 TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL 180
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
Sbjct: 121 TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL 180
Query: 181 AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA 240
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
Sbjct: 181 AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA 240
Query: 241 FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD 300
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
Sbjct: 241 FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD 300
Query: 301 RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG 360
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
Sbjct: 301 RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG 360
Query: 361 YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI 420
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
Sbjct: 361 YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI 420
Query: 421 ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG 467
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
Sbjct: 421 ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG 467
>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
sapiens]
Length = 469
Score = 561 bits (1445), Expect = e-160
Identities = 267/461 (57%), Positives = 342/461 (74%), Gaps = 7/461 (1%)
Query: 10 LLLLHVQISKAFPVS--SKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQ 67
LLL +S +FP + ++E++ VQ YLEK+Y L ++ Q ++ + +VEKLK+MQ
Sbjct: 9 LLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQ 68
Query: 68 RFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEA 127
FFGL VTGKP+ ETL +MK+PRCGVPD F+LT GNP+WE+T+LTYRI NYTP L A
Sbjct: 69 EFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRA 128
Query: 128 EVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPG 187
+V+ AI+ AF+LWS +PL FT++S+G+ADI I+F + DH DNSPFDGP G LAHAFQPG
Sbjct: 129 DVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPG 188
Query: 188 QGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNY 247
GIGGDAHFD +E WTN YNL VAAHE GHSLGL+HS+D GALMYP+Y F + +
Sbjct: 189 PGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF--SGDV 246
Query: 248 SLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRH 307
L QDDIDGIQAIYG S NP+QP GP TPK CD LTFDAITT+RGE++FFKDR++ R +
Sbjct: 247 QLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN 306
Query: 308 PQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDI-S 366
P VE+NFIS+FWP LP G++AAYE DRD + FKGN+YWA+ G ++L GYPKDI S
Sbjct: 307 PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYS 366
Query: 367 NYGFPSSVQAIDAAVFYRS--KTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKV 424
++GFP +V+ IDAA+ + KTYFFV +++WRYD ++ M+PGYPK I+ FPGI KV
Sbjct: 367 SFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV 426
Query: 425 DAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCR 465
DAVF ++ FF+ F G R Y FD +R+ + + N W NCR
Sbjct: 427 DAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCR 467
>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
Length = 403
Score = 525 bits (1352), Expect = e-149
Identities = 246/403 (61%), Positives = 306/403 (75%), Gaps = 5/403 (1%)
Query: 66 MQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLS 125
MQ FFGL VTGKP+ ETL +MK+PRCGVPD F+LT GNP+WE+T+LTYRI NYTP L
Sbjct: 1 MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60
Query: 126 EAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQ 185
A+V+ AI+ AF+LWS +PL FT++S+G+ADI I+F + DH DNSPFDGP G LAHAFQ
Sbjct: 61 RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120
Query: 186 PGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETS 245
PG GIGGDAHFD +E WTN YNL VAAHE GHSLGL+HS+D GALMYP+Y F +
Sbjct: 121 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF--SG 178
Query: 246 NYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWR 305
+ L QDDIDGIQAIYG S NP+QP GP TPK CD LTFDAITT+RGE++FFKDR++ R
Sbjct: 179 DVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMR 238
Query: 306 RHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDI 365
+P VE+NFIS+FWP LP G++AAYE DRD + FKGN+YWA+ G ++L GYPKDI
Sbjct: 239 TNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDI 298
Query: 366 -SNYGFPSSVQAIDAAVFYRS--KTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIES 422
S++GFP +V+ IDAA+ + KTYFFV +++WRYD ++ M+PGYPK I+ FPGI
Sbjct: 299 YSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGH 358
Query: 423 KVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCR 465
KVDAVF ++ FF+ F G R Y FD +R+ + + N W NCR
Sbjct: 359 KVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCR 401
>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
Length = 477
Score = 501 bits (1291), Expect = e-142
Identities = 241/477 (50%), Positives = 329/477 (68%), Gaps = 16/477 (3%)
Query: 4 LKTLPFLLLLHVQISKAFPVSSKEKNTKT----VQDYLEKFYQLPSNQYQSTRKNGTNVI 59
+K+LP LLLL V + A+P+ + T VQ YLE +Y L + Q R+ + +
Sbjct: 1 MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV 60
Query: 60 VEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRN 119
V+K++EMQ+F GL VTGK + +TL++M+KPRCGVPD G F PG PKW +T+LTYRI N
Sbjct: 61 VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN 120
Query: 120 YTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGI 179
YTP L + V+ A++ A ++W +PL F+R+ +GEADI I+F R+HGD PFDGP +
Sbjct: 121 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV 180
Query: 180 LAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNY 239
LAHA+ PG GI GDAHFD +E WT + NLFLVAAHE GHSLGL HS++ ALMYP Y
Sbjct: 181 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY 240
Query: 240 -AFRETSNYSLPQDDIDGIQAIYG----LSSNPIQPTGPSTPKP-----CDPSLTFDAIT 289
+ + + + L QDDI+GIQ++YG P+ PT P P+P CDP+L+FDA++
Sbjct: 241 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS 300
Query: 290 TLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQY 349
TLRGEIL FKDR+FWR+ + E++ IS FWPSLP+G+ AAYE +DL+F+FKGNQ+
Sbjct: 301 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF 360
Query: 350 WALSGYDILQGYPKDISNYGFPSSVQAIDAAVF--YRSKTYFFVNDQFWRYDNQRQFMEP 407
WA+ G ++ GYP+ I GFP +V+ IDAA+ ++KTYFFV D++WR+D +R MEP
Sbjct: 361 WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP 420
Query: 408 GYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNC 464
G+PK I+ FPGI+SK+DAVF++ FF+ F+G FD A++VT + N WLNC
Sbjct: 421 GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 477
>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
Length = 471
Score = 477 bits (1227), Expect = e-134
Identities = 227/440 (51%), Positives = 296/440 (67%), Gaps = 3/440 (0%)
Query: 27 EKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMM 86
E++ + + YL +Y P+N ++N + + E+L+EMQ FFGL VTGK ++ TLD+M
Sbjct: 33 EEDLQFAERYLRSYYH-PTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVM 91
Query: 87 KKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPL 146
KKPRCGVPD G + + P KW + NLTYRI NYTP ++ +EVE+A K AF++WS +PL
Sbjct: 92 KKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPL 151
Query: 147 IFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTS 206
FTR+ G ADI I+F ++HGD PFDGP+G+LAHAF PG GGDAHFD +ETWT++S
Sbjct: 152 NFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSS 211
Query: 207 ANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSN 266
YNLFLVAAHEFGHSLGL HS DPGALM+P Y + S++ LP DD+ GIQ++YG
Sbjct: 212 KGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDE 271
Query: 267 PIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLP 326
P P TP CDPSL+ DAIT+LRGE + FKDR+FWR HPQ E+ FWP LP
Sbjct: 272 DPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELP 331
Query: 327 TGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYR-- 384
I AAYE DLIF+F+G ++WAL+GYDIL+GYPK IS G P V+ I AAV +
Sbjct: 332 NRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDT 391
Query: 385 SKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYA 444
KT F +Q WRYD+ M+ YP+ I FPGI KVDAV+++ + + F+GP +
Sbjct: 392 GKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFE 451
Query: 445 FDLIAQRVTRVARGNKWLNC 464
+ + + R+ RV N L C
Sbjct: 452 YSIWSNRIVRVMPANSILWC 471
>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
Length = 476
Score = 473 bits (1216), Expect = e-133
Identities = 237/474 (50%), Positives = 316/474 (66%), Gaps = 17/474 (3%)
Query: 7 LPFLLLLHVQISKAFPVSSKEK----NTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEK 62
L FL+LL + + A+P+S K N Q YLEK+Y L + Q RK+ +N+IV+K
Sbjct: 4 LAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKD-SNLIVKK 62
Query: 63 LKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTP 122
++ MQ+F GL VTGK + +TL++M+KPRCGVPD G F PG PKW +T+LTYRI NYTP
Sbjct: 63 IQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTP 122
Query: 123 QLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAH 182
L V+ AI+ A ++W +PL F+R+ +GEADI I+F ++HGD FDGP LAH
Sbjct: 123 DLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAH 182
Query: 183 AFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNY-AF 241
A+ PG G+ GD HFD +E WT ++ NLFLVAAHE GHSLGL HS++ ALMYP Y +F
Sbjct: 183 AYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSF 242
Query: 242 RETSNYSLPQDDIDGIQAIYG----LSSNPIQPT-----GPSTPKPCDPSLTFDAITTLR 292
E + + L QDD++GIQ++YG + P+ PT G P CDP+L+FDAI+TLR
Sbjct: 243 TELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLR 302
Query: 293 GEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWAL 352
GE LFFKDRYFWRR E + IS FWPSLP+ + AAYE RD +F+FKGN++WA+
Sbjct: 303 GEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAI 362
Query: 353 SGYDILQGYPKDISNYGFPSSVQAIDAAVF--YRSKTYFFVNDQFWRYDNQRQFMEPGYP 410
G ++ GYP+ I GFP +++ IDAAV + KTYFF D++WR+D Q ME G+P
Sbjct: 363 RGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFP 422
Query: 411 KSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNC 464
+ I+ FPG+E KVDAV Q FF+ FSG + FD A+ VT + + N WL+C
Sbjct: 423 RLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 476
>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
Length = 513
Score = 449 bits (1156), Expect = e-126
Identities = 228/470 (48%), Positives = 298/470 (63%), Gaps = 12/470 (2%)
Query: 4 LKTLPFLLLLHVQISKAFPV---SSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV 60
+K L L L + S AFP+ + E+N + Q YL +FY L + ++I
Sbjct: 1 MKRLLLLFLFFITFSSAFPLVRMTENEENMQLAQAYLNQFYSLEIEGNHLVQSKNRSLID 60
Query: 61 EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY 120
+K++EMQ FFGL VTGK + TL++MK PRCGVPD G + T P W + NLTYRI NY
Sbjct: 61 DKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTL--PGWRKYNLTYRIINY 118
Query: 121 TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSP--FDGPNG 178
TP ++ A V+ AI++ E+WS +PL FT+IS+G ADI IAF R HG P FDGP G
Sbjct: 119 TPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHG-RCPRYFDGPLG 177
Query: 179 ILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPN 238
+L HAF PG G+GGD HFD +E WT A +NLFLVAAHEFGH+LGL+HS+D ALM+PN
Sbjct: 178 VLGHAFPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPN 237
Query: 239 YAFRETSNYSLPQDDIDGIQAIY-GLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILF 297
Y + Y L QDDI+GIQ+IY GL P +P P+ P CDP LTFDAITT R E++F
Sbjct: 238 YVSLDPRKYPLSQDDINGIQSIYGGLPKEPAKPKEPTIPHACDPDLTFDAITTFRREVMF 297
Query: 298 FKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDI 357
FK R+ WR + + VE I+ FWPSLP +QAAYE+ RD I +FK +W + GY +
Sbjct: 298 FKGRHLWRIYYDITDVEFELIASFWPSLPADLQAAYEN-PRDKILVFKDENFWMIRGYAV 356
Query: 358 LQGYPKDISNYGFPSSVQAIDAAVFYRS--KTYFFVNDQFWRYDNQRQFMEPGYPKSISG 415
L YPK I GFP V+ IDAAV ++ KTYFFV WR+D Q M+ G+P+ +
Sbjct: 357 LPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVK 416
Query: 416 AFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCR 465
FPGI +VDA FQ + FF G + + +D+ + +TR+ R N W C+
Sbjct: 417 HFPGISIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQCK 466
>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
sapiens]
Length = 470
Score = 442 bits (1137), Expect = e-124
Identities = 221/465 (47%), Positives = 301/465 (64%), Gaps = 10/465 (2%)
Query: 10 LLLLHVQISKAFPVSSK---EKNTKTVQD-YLEKFYQLPSNQYQSTR-KNGTNVIVEKLK 64
+LLL S A P++S EKN + YLEKFY L N+ T+ K N++ EK++
Sbjct: 6 ILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQ 65
Query: 65 EMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQL 124
EMQ F GL VTG+ + TL+MM PRCGVPD F PG P W + +TYRI NYTP +
Sbjct: 66 EMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDM 125
Query: 125 SEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAF 184
+ +V+ AI+ AF++WS +PL F++I+ G ADI + F + HGD FDG GILAHAF
Sbjct: 126 NREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAF 185
Query: 185 QPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRET 244
PG GIGGDAHFD +E WT S NLFL A HE GHSLGL HSSDP A+M+P Y + +
Sbjct: 186 GPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDI 245
Query: 245 SNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKP--CDPSLTFDAITTLRGEILFFKDRY 302
+ + L DDI GIQ++YG + P +P CDP+L+FDA+TT+ +I FFKDR+
Sbjct: 246 NTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRF 305
Query: 303 FWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYP 362
FW + + + +N IS WP+LP+GI+AAYE R+ +FLFK ++YW +S YP
Sbjct: 306 FWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYP 365
Query: 363 KDISNYGFPSSVQAIDAAVFYRS--KTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI 420
K I ++GFP+ V+ IDAAVF +TYFFV++Q+WRYD +RQ M+PGYPK I+ F GI
Sbjct: 366 KSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGI 425
Query: 421 ESKVDAVFQQEH-FFHVFSGPRYYAFDLIAQRVTRVARGNKWLNC 464
K+DAVF ++ +++ F G + +D + QR+T+ + N W C
Sbjct: 426 GPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC 470
>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
sapiens]
Length = 483
Score = 423 bits (1088), Expect = e-118
Identities = 213/476 (44%), Positives = 296/476 (62%), Gaps = 19/476 (3%)
Query: 7 LPFLLLLHVQISKAFP--VSSKEK----NTKTVQDYLEKFY-QLPSNQYQSTRKNGTNVI 59
L L++ ++ S A P V++ + N + Q YL+K+Y +Q G+N +
Sbjct: 9 LAVFLIMALKFSTAAPSLVAASPRTWRNNYRLAQAYLDKYYTNKEGHQIGEMVARGSNSM 68
Query: 60 VEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRN 119
+ K+KE+Q FFGL VTGK ++ T++++KKPRCGVPD + L PG PKW++ LTYRI
Sbjct: 69 IRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANYRLFPGEPKWKKNTLTYRISK 128
Query: 120 YTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGI 179
YTP +S EV++A++ A + WS A PL F RI+ GEADI I+F DHGD+ PFDGP G
Sbjct: 129 YTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDSYPFDGPRGT 188
Query: 180 LAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNY 239
LAHAF PG+G+GGD HFD E WT + +NLF VAAHEFGH+LGLAHS+DP ALMYP Y
Sbjct: 189 LAHAFAPGEGLGGDTHFDNAEKWTMGTNGFNLFTVAAHEFGHALGLAHSTDPSALMYPTY 248
Query: 240 AFRETSNYSLPQDDIDGIQAIYG----LSSNPIQPTG----PSTPKPCDPSLTFDAITTL 291
++ + LP+DD+ GIQA+YG P P PS P CD S +FDA+T L
Sbjct: 249 KYKNPYGFHLPKDDVKGIQALYGPRKVFLGKPTLPHAPHHKPSIPDLCDSSSSFDAVTML 308
Query: 292 RGEILFFKDRYFWRRHPQLQR-VEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYW 350
E+L FKDR FWRR L+ + + I+ +P L + + AAYE +R + FKG YW
Sbjct: 309 GKELLLFKDRIFWRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYW 368
Query: 351 ALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYR--SKTYFFVNDQFWRYDNQRQFMEPG 408
G+ +QG P+ I ++GFP VQ IDAAV+ R KT FFV D+++ YD +++ ME
Sbjct: 369 ITRGFQ-MQGPPRTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKRKMEKD 427
Query: 409 YPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNC 464
YPK+ F G+ ++DA + + + FSGP+ Y +D + V V + + W+ C
Sbjct: 428 YPKNTEEEFSGVNGQIDAAVELNGYIYFFSGPKTYKYDTEKEDVVSVVKSSSWIGC 483
>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
Length = 645
Score = 316 bits (809), Expect = 3e-86
Identities = 176/469 (37%), Positives = 252/469 (53%), Gaps = 58/469 (12%)
Query: 34 QDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGV 93
Q++L+ + L +++ + + + MQ+F+G+ VTG ++ T++ MKKPRCGV
Sbjct: 82 QNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGV 141
Query: 94 PDSGGFMLTPGNP-------KWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPL 146
PD N KW + ++TY I NYTP++ E + +AI+ AF++W +PL
Sbjct: 142 PDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPL 201
Query: 147 IFTRI-------SQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAE 199
F + + EADI I F HGD+SPFDG G LAHA+ PG GIGGD HFD++
Sbjct: 202 TFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSD 261
Query: 200 ETWTNTSANYN---LFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDG 256
E WT +AN++ LFLVA HE GH+LGL HSSDP A+M P Y + ET N+ LPQDD+ G
Sbjct: 262 EPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQG 321
Query: 257 IQAIYGLSSNPIQPTGP------------------STPKPCDPSL--------------- 283
IQ IYG + P++PT P P+P P L
Sbjct: 322 IQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNICD 381
Query: 284 -TFDAITTLRGEILFFKDRYFWR-RHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLI 341
F+ + RGE+ FKDR+FWR R+ ++Q I FW LP I AAYE D +
Sbjct: 382 GNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFV 441
Query: 342 FLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYR--SKTYFFVNDQFWRYD 399
F FKG++YW + GYP + G + ID A+ + KTYFF +++WRY
Sbjct: 442 F-FKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYS 500
Query: 400 NQRQFMEPGYPKSISGAFPGIESKVDAVF--QQEHFFHVFSGPRYYAFD 446
+R+ +PGYPK I+ + GI F ++ ++ + + G Y+ FD
Sbjct: 501 EERRATDPGYPKPIT-VWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFD 548
>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
[Homo sapiens]
Length = 607
Score = 311 bits (797), Expect = 8e-85
Identities = 176/473 (37%), Positives = 248/473 (52%), Gaps = 63/473 (13%)
Query: 33 VQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCG 92
V+ +L+K+ LP + + + L MQ+F+G+N+TGK + T+D MKKPRCG
Sbjct: 43 VEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG 102
Query: 93 VPDSGG-----------FMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWS 141
VPD + LT KW+ ++TY I+N TP++ + E +AI+ AF++W
Sbjct: 103 VPDQTRGSSKFHIRRKRYALT--GQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQ 160
Query: 142 VASPLIFTRISQGE-------ADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDA 194
+PL F + E DI I F HGD+SPFDG G LAHA+ PG GIGGD
Sbjct: 161 NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDT 220
Query: 195 HFDAEETWTNTSANYN---LFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQ 251
HFD++E WT + N++ LFLVA HE GH+LGL HS+DP A+M P Y + ET N+ LP
Sbjct: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
Query: 252 DDIDGIQAIYG------------------LSSNPIQPTGPSTPKPCDPSL---------- 283
DD+ GIQ IYG S P P PKP P
Sbjct: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340
Query: 284 -----TFDAITTLRGEILFFKDRYFWR-RHPQLQRVEMNFISLFWPSLPTGIQAAYEDFD 337
F+ + LR E+ FKD++FWR R+ ++ I+ FW LP I A YE+ D
Sbjct: 341 NICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSD 400
Query: 338 RDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYR--SKTYFFVNDQF 395
+ +F FKGN+YW + GYP D+ G ID+A+++ KTYFF D++
Sbjct: 401 GNFVF-FKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRY 459
Query: 396 WRYDNQRQFMEPGYPKSISGAFPGIESKVDAVF--QQEHFFHVFSGPRYYAFD 446
WRY + + M+PGYPK I+ + GI F ++ F + + G Y+ F+
Sbjct: 460 WRYSEEMKTMDPGYPKPIT-VWKGIPESPQGAFVHKENGFTYFYKGKEYWKFN 511
>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
Length = 669
Score = 303 bits (775), Expect = 3e-82
Identities = 185/519 (35%), Positives = 260/519 (50%), Gaps = 85/519 (16%)
Query: 5 KTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLK 64
+ LP LL+L + E + +++L + LP + ++ L
Sbjct: 28 RLLPLLLVLLGCLGLGVAAEDAEVHA---ENWLRLYGYLPQPSRHMSTMRSAQILASALA 84
Query: 65 EMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPG-----------NPKWERTNL 113
EMQRF+G+ VTG +EET + MK+PRCGVPD G + KW +L
Sbjct: 85 EMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHL 144
Query: 114 TYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRIS--------QGEADINIAFYQR 165
T+ I+NYT +L A++ AF +W A+PL+F + Q EADI + F
Sbjct: 145 TFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASG 204
Query: 166 DHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANY---NLFLVAAHEFGHS 222
HGD+SPFDG G LAHA+ PG G+GGD HFDA+E WT +S + NLFLVA HE GH+
Sbjct: 205 FHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHA 264
Query: 223 LGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGP---STPK-- 277
LGL HSS+P A+M P Y +++ N+ LP+DD+ GIQ +YG QPT P TP+
Sbjct: 265 LGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRP 324
Query: 278 ----------------------------PCDPSLT--------------FDAITTLRGEI 295
P P T FD + LRGE+
Sbjct: 325 GRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAMLRGEM 384
Query: 296 LFFKDRYFWR-RHPQLQRVEMNF---ISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWA 351
FK R+FWR RH RV N+ I FW LP I AAYE D +F FKG++YW
Sbjct: 385 FVFKGRWFWRVRH---NRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVF-FKGDRYWL 440
Query: 352 LSGYDILQGYPKDISNYGFPSSVQAIDAAVFYR--SKTYFFVNDQFWRYDNQRQFMEPGY 409
++ GYP+ +++YG ID A+++ T+FF D++WR++ + Q +PGY
Sbjct: 441 FREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGY 500
Query: 410 PKSISGAFPGIESKVDAVF--QQEHFFHVFSGPRYYAFD 446
PK IS + GI + F + + + G +Y+ FD
Sbjct: 501 PKPIS-VWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFD 538
>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
Length = 582
Score = 291 bits (746), Expect = 7e-79
Identities = 169/465 (36%), Positives = 250/465 (53%), Gaps = 43/465 (9%)
Query: 23 VSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEET 82
+ S + ++ + + +L+++ LP ++ + + + MQ+F+GL VTGK + +T
Sbjct: 25 LGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADT 84
Query: 83 LDMMKKPRCGVPDSGGFMLTPG---------NPKWERTNLTYRIRNYTPQLSEAEVERAI 133
+ M++PRCGVPD G + KW+ +T+ I+NYTP++ E AI
Sbjct: 85 MKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAI 144
Query: 134 KDAFELWSVASPLIFTRIS--------QGEADINIAFYQRDHGDNSPFDGPNGILAHAFQ 185
+ AF +W A+PL F + + +ADI I F + HGD++PFDG G LAHA+
Sbjct: 145 RKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYF 204
Query: 186 PGQGIGGDAHFDAEETWTNTSANYN---LFLVAAHEFGHSLGLAHSSDPGALMYPNYAFR 242
PG IGGD HFD+ E WT + + N +FLVA HE GH+LGL HSSDP A+M P Y +
Sbjct: 205 PGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWM 264
Query: 243 ETSNYSLPQDDIDGIQAIYGLSSN-----PIQPTGPSTP----KPCDPSL-------TFD 286
+T N+ LP DD GIQ +YG S P QP S P KP +P+ FD
Sbjct: 265 DTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFD 324
Query: 287 AITTLRGEILFFKDRYFWR-RHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFK 345
+ LRGE+ FK+R+FWR R+ Q+ I FW LP I AYE D +F FK
Sbjct: 325 TVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVF-FK 383
Query: 346 GNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFY--RSKTYFFVNDQFWRYDNQRQ 403
G+++W + GYPK I G IDAA+F+ KTYFF ++++R++ + +
Sbjct: 384 GDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELR 443
Query: 404 FMEPGYPKSISGAFPGIESKVDAVF--QQEHFFHVFSGPRYYAFD 446
++ YPK+I + GI F E F + + G +Y+ F+
Sbjct: 444 AVDSEYPKNIK-VWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFN 487
>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
[Homo sapiens]
Length = 457
Score = 244 bits (623), Expect = 1e-64
Identities = 139/365 (38%), Positives = 191/365 (52%), Gaps = 57/365 (15%)
Query: 33 VQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCG 92
V+ +L+K+ LP + + + L MQ+F+G+N+TGK + T+D MKKPRCG
Sbjct: 43 VEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG 102
Query: 93 VPDSGG-----------FMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWS 141
VPD + LT KW+ ++TY I+N TP++ + E +AI+ AF++W
Sbjct: 103 VPDQTRGSSKFHIRRKRYALT--GQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQ 160
Query: 142 VASPLIFTRISQGE-------ADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDA 194
+PL F + E DI I F HGD+SPFDG G LAHA+ PG GIGGD
Sbjct: 161 NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDT 220
Query: 195 HFDAEETWTNTSANYN---LFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQ 251
HFD++E WT + N++ LFLVA HE GH+LGL HS+DP A+M P Y + ET N+ LP
Sbjct: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
Query: 252 DDIDGIQAIYG------------------LSSNPIQPTGPSTPKPCDPSL---------- 283
DD+ GIQ IYG S P P PKP P
Sbjct: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340
Query: 284 -----TFDAITTLRGEILFFKDRYFWR-RHPQLQRVEMNFISLFWPSLPTGIQAAYEDFD 337
F+ + LR E+ FKD++FWR R+ ++ I+ FW LP I A YE+ D
Sbjct: 341 NICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSD 400
Query: 338 RDLIF 342
+ +F
Sbjct: 401 GNFVF 405
Score = 32.3 bits (72), Expect = 0.94
Identities = 17/54 (31%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 384 RSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVF 437
R + + F + FWR N R + GYP I+ + G+ +DAV++ VF
Sbjct: 354 RREMFVFKDQWFWRVRNNR--VMDGYPMQITYFWRGLPPSIDAVYENSDGNFVF 405
>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
sapiens]
Length = 603
Score = 237 bits (605), Expect = 1e-62
Identities = 159/483 (32%), Positives = 237/483 (49%), Gaps = 52/483 (10%)
Query: 7 LPFLLLLHVQISKAFPVSSKEKNTKTVQ---DYLEKFYQLPSNQYQSTRKNGTNVIVEKL 63
LP LLLL + + + + ++L +F LP + + + + +
Sbjct: 23 LPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAI 82
Query: 64 KEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLT--------PGNPKWERTNLTY 115
MQ+F GL TG +E TL +MK PRC +PD +LT P KW + NL++
Sbjct: 83 TAMQQFGGLEATGILDEATLALMKTPRCSLPDLP--VLTQARRRRQAPAPTKWNKRNLSW 140
Query: 116 RIRNYTPQ--LSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPF 173
R+R + L V + A ++WS +PL F ++ ADI I F + DH D PF
Sbjct: 141 RVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPF 200
Query: 174 DGPNGILAHAFQPG-QGIGGDAHFDAEETWTNTSAN---YNLFLVAAHEFGHSLGLAHSS 229
DGP G +AHAF PG GD HFD +E WT S++ +LF VA HEFGH++GL+H +
Sbjct: 201 DGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVA 260
Query: 230 DPGALMYPNY--AFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTG-----PSTPKPCDP- 281
++M P Y + Y LP +D + +YG+ + + PT P P+P D
Sbjct: 261 AAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRES-VSPTAQPEEPPLLPEPPDNR 319
Query: 282 -------------SLTFDAITTLRGEILFFKDRYFWR--RHPQLQRVEMNFISLFWPSLP 326
S FDA+ +RGE FFK +YFWR R L ++ + FW LP
Sbjct: 320 SSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLP 379
Query: 327 ---TGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAV-- 381
+ A YE I FKG++YW ++ +GYP+ +S++ P IDAA
Sbjct: 380 LHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPG--GIDAAFSW 437
Query: 382 FYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKV-DAVFQQEHFFHVFSGP 440
+ +TYFF + +WRYD+ + M+PGYP S + G+ S + DA+ + + F G
Sbjct: 438 AHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQ-SPLWRGVPSTLDDAMRWSDGASYFFRGQ 496
Query: 441 RYY 443
Y+
Sbjct: 497 EYW 499
>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
Length = 267
Score = 236 bits (601), Expect = 4e-62
Identities = 118/241 (48%), Positives = 148/241 (61%), Gaps = 7/241 (2%)
Query: 27 EKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMM 86
E + QDYL++FY Y S KN N + KLKEMQ+FFGL +TG N +++M
Sbjct: 29 ELQWEQAQDYLKRFYL-----YDSETKNA-NSLEAKLKEMQKFFGLPITGMLNSRVIEIM 82
Query: 87 KKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPL 146
+KPRCGVPD + L P +PKW +TYRI +YT L V+R + A +W PL
Sbjct: 83 QKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPL 142
Query: 147 IFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTN-T 205
F ++ G ADI I F + HGD+ PFDGP LAHAF PG G+GGDAHFD +E WT+ +
Sbjct: 143 HFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGS 202
Query: 206 SANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSS 265
S N A HE GHSLG+ HSSDP A+MYP Y + N+ L QDDI GIQ +YG S
Sbjct: 203 SLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRS 262
Query: 266 N 266
N
Sbjct: 263 N 263
>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
sapiens]
Length = 562
Score = 233 bits (595), Expect = 2e-61
Identities = 177/511 (34%), Positives = 239/511 (46%), Gaps = 57/511 (11%)
Query: 4 LKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKL 63
L+ L LLLL ++A S+++ + D+L ++ LP + + + +
Sbjct: 5 LRLLALLLLLLAPPARAPKPSAQDVSLGV--DWLTRYGYLPPPHPAQAQLQSPEKLRDAI 62
Query: 64 KEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFM--------LTPGNPKWERTNLTY 115
K MQRF GL TG+ + T+ M+KPRC +PD G W++ LT+
Sbjct: 63 KVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTW 122
Query: 116 RIRNY--TPQLSEAEVERAIKDAFELWSVASPLIFTRIS--QG-EADINIAFYQRDHGDN 170
R+R++ + QLS+ V + A W + S L F + QG E DI I F + H D+
Sbjct: 123 RVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDS 182
Query: 171 SPFDGPNGILAHAFQPGQG-IGGDAHFDAEETWTNTSAN---YNLFLVAAHEFGHSLGLA 226
PFDG G LAHAF PG+ I GD HFD EETWT S + +LF VA HEFGH+LGL
Sbjct: 183 YPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLG 242
Query: 227 HSSDPGALMYPNY--AFRETSNYSLPQDDIDGIQAIYGLSSN-----------------P 267
HSS P ++M P Y + Y L QDD DG+Q +YG + P
Sbjct: 243 HSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPP 302
Query: 268 IQPT-GPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISL--FWPS 324
PT PS P P FDAI +RGE FFK +FWR P Q V L FW
Sbjct: 303 ASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEG 362
Query: 325 LPTG---IQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAV 381
LP +QAAY I LF G Q+W L+G + ++ G P + +DA
Sbjct: 363 LPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQ-LEGGARPLTELGLPPG-EEVDAVF 420
Query: 382 FY--RSKTYFFVNDQFWRYDNQRQFMEPGYPKSIS---GAFPGIESKVDAVFQQEHFFHV 436
+ KTY Q+WRYD +PGYP+ +S GA P S D +
Sbjct: 421 SWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPP---SPDDVTVSNAGDTYF 477
Query: 437 FSGPRYYAFDLIAQRVTRVA---RGNKWLNC 464
F G Y+ F + + A G WL+C
Sbjct: 478 FKGAHYWRFPKNSIKTEPDAPQPMGPNWLDC 508
>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
sapiens]
Length = 488
Score = 226 bits (577), Expect = 3e-59
Identities = 147/398 (36%), Positives = 210/398 (52%), Gaps = 50/398 (12%)
Query: 86 MKKPRCGVPDSGG----------FMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKD 135
++ PRCGVPD F+L+ G +WE+T+LTYRI + QL + +V + + +
Sbjct: 75 LRPPRCGVPDPSDGLSARNRQKRFVLSGG--RWEKTDLTYRILRFPWQLVQEQVRQTMAE 132
Query: 136 AFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAH 195
A ++WS +PL FT + +G ADI I F + HGD+ PFDGP GILAHAF P GD H
Sbjct: 133 ALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVH 192
Query: 196 FDAEETWT-NTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDI 254
FD +ETWT +L VAAHEFGH LGL H++ ALM Y FR SL DD
Sbjct: 193 FDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP--LSLSPDDC 250
Query: 255 DGIQAIY------------------GLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEIL 296
G+Q +Y G+ +N I P P P P +FDA++T+RGE+
Sbjct: 251 RGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAP-PDACEASFDAVSTIRGELF 309
Query: 297 FFKDRYFWR-RHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGY 355
FFK + WR R QLQ S W LP+ + AA+ED + I+ F+G QYW G
Sbjct: 310 FFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFED-AQGHIWFFQGAQYWVYDGE 368
Query: 356 DILQGYPKDISNYG---FPSSVQAIDAAVFY---RSKTYFFVNDQFWRYDNQRQFMEPGY 409
+ G P ++ G FP + AA+ + ++K YFF +WR+ + ++
Sbjct: 369 KPVLG-PAPLTELGLVRFP-----VHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPV 422
Query: 410 PKSISGAFPGIESKVDAVFQQ-EHFFHVFSGPRYYAFD 446
P+ + + G+ S++DA FQ + + + G Y+ FD
Sbjct: 423 PRRATD-WRGVPSEIDAAFQDADGYAYFLRGRLYWKFD 459
>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
Length = 610
Score = 212 bits (539), Expect = 7e-55
Identities = 116/284 (40%), Positives = 157/284 (55%), Gaps = 15/284 (5%)
Query: 194 AHFDAEETWTNT-SANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQD 252
A++D + W Y+LFLVAAHEFGH++GL HS DPGALM P Y + T N+ L QD
Sbjct: 329 ANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQD 386
Query: 253 DIDGIQAIYG------LSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRR 306
DI GIQ +YG L + P GP TP+ C + FD I +RGEI FFKDR+ WR
Sbjct: 387 DIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT 446
Query: 307 -HPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDI 365
P+ + + ++ FWP LP I A YE + F GN+YW S + +GYPK +
Sbjct: 447 VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPL 506
Query: 366 SNYGFPSSVQAIDAAVFY--RSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESK 423
++ G P VQ +DAA + KTY F D+FWRY+ ++ M+PG+PK I+ A+ I
Sbjct: 507 TSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDN 566
Query: 424 VDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARG---NKWLNC 464
+DAV + H + Y L Q + V G + WL C
Sbjct: 567 LDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 610
Score = 168 bits (426), Expect = 8e-42
Identities = 83/170 (48%), Positives = 107/170 (62%), Gaps = 10/170 (5%)
Query: 36 YLEKFYQLPSNQYQSTRKNGTNVIVEK--LKEMQRFFGLNVTGKPNEETLDMMKKPRCGV 93
YL FY P K N+ V K LK+MQ+FFGL TG ++ T++ M+KPRCG
Sbjct: 3 YLNTFYGCP--------KESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGN 54
Query: 94 PDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQ 153
PD + P PKW++ +TYRI YTP L V+ A AF++WS +PL F+RI
Sbjct: 55 PDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHD 114
Query: 154 GEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWT 203
GEADI I F + +HGD PFDG +G+LAHAF PG G+GGD+HFD +E WT
Sbjct: 115 GEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWT 164
>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
[Homo sapiens]
Length = 660
Score = 212 bits (539), Expect = 7e-55
Identities = 116/284 (40%), Positives = 157/284 (55%), Gaps = 15/284 (5%)
Query: 194 AHFDAEETWTNT-SANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQD 252
A++D + W Y+LFLVAAHEFGH++GL HS DPGALM P Y + T N+ L QD
Sbjct: 379 ANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQD 436
Query: 253 DIDGIQAIYG------LSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRR 306
DI GIQ +YG L + P GP TP+ C + FD I +RGEI FFKDR+ WR
Sbjct: 437 DIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT 496
Query: 307 -HPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDI 365
P+ + + ++ FWP LP I A YE + F GN+YW S + +GYPK +
Sbjct: 497 VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPL 556
Query: 366 SNYGFPSSVQAIDAAVFY--RSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESK 423
++ G P VQ +DAA + KTY F D+FWRY+ ++ M+PG+PK I+ A+ I
Sbjct: 557 TSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDN 616
Query: 424 VDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARG---NKWLNC 464
+DAV + H + Y L Q + V G + WL C
Sbjct: 617 LDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 660
Score = 169 bits (428), Expect = 5e-42
Identities = 87/186 (46%), Positives = 112/186 (60%), Gaps = 11/186 (5%)
Query: 21 FPVSSKEKNTKTVQ-DYLEKFYQLPSNQYQSTRKNGTNVIVEK--LKEMQRFFGLNVTGK 77
FP K K + YL FY P K N+ V K LK+MQ+FFGL TG
Sbjct: 37 FPGDVAPKTDKELAVQYLNTFYGCP--------KESCNLFVLKDTLKKMQKFFGLPQTGD 88
Query: 78 PNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAF 137
++ T++ M+KPRCG PD + P PKW++ +TYRI YTP L V+ A AF
Sbjct: 89 LDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAF 148
Query: 138 ELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFD 197
++WS +PL F+RI GEADI I F + +HGD PFDG +G+LAHAF PG G+GGD+HFD
Sbjct: 149 QVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFD 208
Query: 198 AEETWT 203
+E WT
Sbjct: 209 DDELWT 214
>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
sapiens]
Length = 261
Score = 187 bits (474), Expect = 2e-47
Identities = 91/228 (39%), Positives = 132/228 (57%), Gaps = 4/228 (1%)
Query: 35 DYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVP 94
D++E ++ +Q+ T+K + E ++ + F N T + + ++ +P CGVP
Sbjct: 30 DFVEGYF----HQFFLTKKESPLLTQETQTQLLQQFHRNGTDLLDMQMHALLHQPHCGVP 85
Query: 95 DSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQG 154
D ++PG KW + LTYRI NY + + V+ +I +A +WS +PLIF ++ G
Sbjct: 86 DGSDTSISPGRCKWNKHTLTYRIINYPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQVQNG 145
Query: 155 EADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLV 214
+ADI ++F+Q H D PFDGP GIL HAF P G G HFD E W+ + YNLFLV
Sbjct: 146 DADIKVSFWQWAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFDKNEHWSASDTGYNLFLV 205
Query: 215 AAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYG 262
A HE GHSLGL HS + ++MYP Y + + + L DDI IQ +YG
Sbjct: 206 ATHEIGHSLGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQRIQHLYG 253
>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
[Homo sapiens]
Length = 508
Score = 183 bits (464), Expect = 3e-46
Identities = 144/469 (30%), Positives = 213/469 (45%), Gaps = 63/469 (13%)
Query: 35 DYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVP 94
DYL ++ L + + I E L+ Q L V+G+ ++ T M++PRCG+
Sbjct: 30 DYLSQYGYL-QKPLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGLE 88
Query: 95 DSGGFMLTPGNPK---------WERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASP 145
D P N K W + +LT+RI N L A++ AF+ WS +P
Sbjct: 89 D-------PFNQKTLKYLLLGRWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAP 141
Query: 146 LIFTRISQGEADINIAFYQRDHG-DNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWT- 203
L F + G ADI ++F+ R ++ FDGP +LAHA P G HFD +E WT
Sbjct: 142 LTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHADIPEL---GSVHFDEDEFWTE 198
Query: 204 NTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNY-AFRETSNYSLPQDDIDGIQAIYG 262
T NL ++AAHE GH+LGL HS ALM P Y +R ++ L DD+ GIQA+YG
Sbjct: 199 GTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYR--PHFKLHPDDVAGIQALYG 256
Query: 263 ---------------LSSNPIQPTGPS-TPKPCDPSLTFDAITT-LRGEILFFKDRYFWR 305
L + P PT PS P PC L DA+ RG+ FK Y W
Sbjct: 257 KKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSEL--DAMMLGPRGKTYAFKGDYVWT 314
Query: 306 RHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDI 365
+ +S W LP + AA I FKG++ W + + G+PK +
Sbjct: 315 VSDS-GPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKL 373
Query: 366 SNYGFPSSVQAIDAAVFY--RSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESK 423
+ +DAA+++ K + F +W++D + YPK I G F G+ ++
Sbjct: 374 NRV-----EPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQ 428
Query: 424 VDAVFQ-QEHFFHVFSGPRYYAFDLIAQRVTRVARG------NKWLNCR 465
A Q+ + F G Y+ + + RV +G + W++CR
Sbjct: 429 PSAAMSWQDGRVYFFKGKVYWRLN----QQLRVEKGYPRNISHNWMHCR 473
>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
[Homo sapiens]
Length = 520
Score = 172 bits (436), Expect = 6e-43
Identities = 158/518 (30%), Positives = 228/518 (44%), Gaps = 73/518 (14%)
Query: 4 LKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKL 63
L+ L LL H+ A ++ K + +LEK+ L Q + + + +
Sbjct: 9 LRALQLLLWGHLDAQPA--ERGGQELRKEAEAFLEKYGYLNE---QVPKAPTSTRFSDAI 63
Query: 64 KEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGF-----------------------M 100
+ Q L V+G + TL M +PRCGV D+ +
Sbjct: 64 RAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRF 123
Query: 101 LTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRI-SQGEADIN 159
GN KW + +L+YR+ N+ L E V A++ AF+LWS S L F + G ADI
Sbjct: 124 AKQGN-KWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIR 182
Query: 160 IAFYQRDHGDN--SPFDGPNGILAHAFQPGQGIGGDAHFDAEETWT-NTSANYNLFLVAA 216
+ F+Q DH D + FDGP G LAHAF P +G +AHFD +E W+ + NLF+V A
Sbjct: 183 LTFFQGDHNDGLGNAFDGPGGALAHAFLPRRG---EAHFDQDERWSLSRRRGRNLFVVLA 239
Query: 217 HEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGL---SSNPIQPTG- 272
HE GH+LGL HS P ALM P Y R + L DD+ +Q++YG S +Q G
Sbjct: 240 HEIGHTLGLTHSPAPRALMAPYYK-RLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGK 298
Query: 273 -----------------PST--PKPCDPSLTFDAITTLRGEILF-FKDRYFWRRHPQLQR 312
P T PK C S FDAIT R + L+ FK +FW
Sbjct: 299 LFTDFETWDSYSPQGRRPETQGPKYCHSS--FDAITVDRQQQLYIFKGSHFWEVAADGNV 356
Query: 313 VEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPS 372
E + W LP I+AA + + FKG + W G + G P+ G P
Sbjct: 357 SEPRPLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLP- 415
Query: 373 SVQAIDAAVFY--RSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVD-AVFQ 429
+ DAA+F+ + F +++ +EP YP+S+ + GI +V A+ +
Sbjct: 416 --RHPDAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQD-WGGIPEEVSGALPR 472
Query: 430 QEHFFHVFSGPRYYAFDLIAQRVT---RVARGNKWLNC 464
+ F RY+ D + T R A W+ C
Sbjct: 473 PDGSIIFFRDDRYWRLDQAKLQATTSGRWATELPWMGC 510
>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
Length = 707
Score = 142 bits (358), Expect = 6e-34
Identities = 68/138 (49%), Positives = 87/138 (63%)
Query: 66 MQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLS 125
+Q+ L TG+ + TL M+ PRCGVPD G F G+ KW N+TY I+NY+ L
Sbjct: 74 LQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLP 133
Query: 126 EAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQ 185
A ++ A AF LWS +PL FTR+ +ADI I F +HGD PFDG +G+LAHAF
Sbjct: 134 RAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFP 193
Query: 186 PGQGIGGDAHFDAEETWT 203
PG GI GDAHFD +E W+
Sbjct: 194 PGPGIQGDAHFDDDELWS 211
Score = 120 bits (301), Expect = 3e-27
Identities = 91/308 (29%), Positives = 134/308 (43%), Gaps = 63/308 (20%)
Query: 194 AHFDAEETWTNT-SANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQD 252
++FD+++ W Y+LFLVAAHEFGH+LGL HSS P ALMYP Y F T L +D
Sbjct: 377 SNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRF--TEGPPLHKD 434
Query: 253 DIDGIQAIYGLSSNP-----------------IQPTGPSTPKPCD--------------- 280
D++GI+ +YG P + PTGP T P +
Sbjct: 435 DVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPT 494
Query: 281 ------PSLT----------------FDAITTLRGEILFFKDRYFWR-RHPQLQRVEMNF 317
PS FDAI + ++ FKD +WR + R + F
Sbjct: 495 GPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQGPF 554
Query: 318 -ISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQA 376
I+ WP+LP + + +E+ +F F G Q W +G +L P+ + G + V
Sbjct: 555 LIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLG--PRRLDKLGLGADVAQ 612
Query: 377 IDAAV-FYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFH 435
+ A+ R K F + WR+D + Q ++P + FPG+ VFQ +
Sbjct: 613 VTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQYREKAY 672
Query: 436 VFSGPRYY 443
F R+Y
Sbjct: 673 -FCQDRFY 679
>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
sapiens]
Length = 569
Score = 130 bits (326), Expect = 3e-30
Identities = 136/463 (29%), Positives = 194/463 (41%), Gaps = 102/463 (22%)
Query: 59 IVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDS-----GGFMLTPGNPKWERTNL 113
+ E ++ QR L +G+ + TL M +PRCGVPD PG P R+
Sbjct: 85 LAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRR 144
Query: 114 TYRI------RNYTP----------------------------QLSEAEVERAIKDAFEL 139
+ R R + P QLS A+ R + AF +
Sbjct: 145 SPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRM 204
Query: 140 WSVASPLIFTR--ISQGEA-DINIAFYQRDH-GDNSPFDGPNGILAHAFQPGQGIGGDAH 195
WS +PL F + G A DI + F + H G FDG AHA++ G D H
Sbjct: 205 WSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIH 259
Query: 196 FDAEETWT--NTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDD 253
FD +E +T + +L VA HE GH LGL H+ G++M PNY +E + + L D
Sbjct: 260 FDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPA-FELDWSD 318
Query: 254 IDGIQAIYGLSSNPIQPTGPSTPKPCDPSL--TFDAITTLR---GEIL------FFKDRY 302
IQ +YG C+ S FD I R GE++ FF++ +
Sbjct: 319 RKAIQKLYG---------------SCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSW 363
Query: 303 FW---RRHPQLQRVEMNFISLFWPSLPTGIQAAYE---DFDRDLIFLFKGNQYW------ 350
+W R+ + + + I WP +PT A+ + RD + F+GNQYW
Sbjct: 364 YWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDK 423
Query: 351 --ALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSK--TYFFVNDQFWRYDNQRQFME 406
AL+ + + YPK IS GFP +D A + R + YFF + +D R +
Sbjct: 424 DQALTEDEQGKSYPKLISE-GFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVL 482
Query: 407 PGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRY-YAFDLI 448
YPK I+ FP AV Q H F Y YA++ I
Sbjct: 483 NSYPKRITEVFP-------AVIPQNHPFRNIDSAYYSYAYNSI 518
Score = 30.0 bits (66), Expect = 4.7
Identities = 25/87 (28%), Positives = 35/87 (40%), Gaps = 13/87 (14%)
Query: 273 PSTPKPCDPSLTFDAITTLRGEILFFKDRYFW----RRHPQLQRVEMNFISLFWPSLPTG 328
P P P D + +D L I FFK+ + R+ L +F +P
Sbjct: 445 PGIPSPLDTAF-YDRRQKL---IYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQN 500
Query: 329 -----IQAAYEDFDRDLIFLFKGNQYW 350
I +AY + + IF FKGN YW
Sbjct: 501 HPFRNIDSAYYSYAYNSIFFFKGNAYW 527
>gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]
Length = 390
Score = 108 bits (270), Expect = 1e-23
Identities = 70/181 (38%), Positives = 92/181 (50%), Gaps = 22/181 (12%)
Query: 99 FMLTPGNPKWERTNLTYRIRNYTPQL-SEAEVERAIKDAFELWSVASPLIFTRISQGE-A 156
+ LTP +W+ NLTYRI ++ L S E RA+ AF +WS SP F ++ + +
Sbjct: 79 YTLTPARLRWDHFNLTYRILSFPRNLLSPRETRRALAAAFRMWSDVSPFSFREVAPEQPS 138
Query: 157 DINIAFYQRDHGD------NSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYN 210
D+ I FY +H D + FDGP G LAHAF P G HFD E W Y+
Sbjct: 139 DLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFPPHG---GIHFDDSEYWVLGPTRYS 195
Query: 211 ---------LFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIY 261
L VAAHE GH+LGL HS ALM+ N R +L QD++ G+ +Y
Sbjct: 196 WKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWK--ALSQDELWGLHRLY 253
Query: 262 G 262
G
Sbjct: 254 G 254
>gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]
Length = 358
Score = 104 bits (259), Expect = 2e-22
Identities = 72/194 (37%), Positives = 93/194 (47%), Gaps = 51/194 (26%)
Query: 12 LLHVQISKAFPVSSKEKNTKTVQDYLEK-FYQLPSNQYQSTRKNGTNVIVEKLKEMQRFF 70
LL++ + FP S YLE +Y L S Q R+ ++ ++EKLK+MQ FF
Sbjct: 129 LLYLTAQQQFPQESFPVK------YLENCYYNLKSEINQIGRQRDSSPVLEKLKQMQNFF 182
Query: 71 GLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVE 130
GL + +NY P L + +V+
Sbjct: 183 GL-------------------------------------------KDQNYMPNLPQEDVD 199
Query: 131 RAIKDAFELWSVASPLIFTRISQGEADINIAF-YQRDHGDNSPFDGPNGILAHAFQPGQG 189
RA AFELWS AS L FTR + E DI ++F + D DNSPF G +G LAHAF PG G
Sbjct: 200 RATGKAFELWSNASALTFTRDFESEGDIILSFVFLADLHDNSPFYGHDGCLAHAFPPGPG 259
Query: 190 IGGDAHFDAEETWT 203
IGGD HFD +ET T
Sbjct: 260 IGGDVHFDNDETRT 273
Score = 72.8 bits (177), Expect = 6e-13
Identities = 34/83 (40%), Positives = 54/83 (65%), Gaps = 4/83 (4%)
Query: 344 FKGNQYWALSGYDILQGYPKDI-SNYGFPSSVQAIDAAVFYRS--KTYFFVNDQFWRYDN 400
F+ +++W + +L GYP+D+ S++ FP V+ IDAA++ + KT+FFV +++WRYD
Sbjct: 276 FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDE 335
Query: 401 QRQFMEPGYPKSISGAFPGIESK 423
Q ++ GYPK I PGI K
Sbjct: 336 NMQSVDAGYPKIIDD-LPGISKK 357
>gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]
Length = 198
Score = 95.9 bits (237), Expect = 7e-20
Identities = 52/101 (51%), Positives = 63/101 (62%), Gaps = 7/101 (6%)
Query: 104 GNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAF- 162
G KW+ +NY P L + +V+RA AFELWS AS L FTR + E DI ++F
Sbjct: 19 GIQKWQED------QNYMPNLPQEDVDRATGKAFELWSKASALTFTRDFESEGDIILSFV 72
Query: 163 YQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWT 203
+ D DNSPF G +G LAHAF PG GIGGD HFD +ET T
Sbjct: 73 FLADLHDNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRT 113
Score = 72.8 bits (177), Expect = 6e-13
Identities = 34/83 (40%), Positives = 54/83 (65%), Gaps = 4/83 (4%)
Query: 344 FKGNQYWALSGYDILQGYPKDI-SNYGFPSSVQAIDAAVFYRS--KTYFFVNDQFWRYDN 400
F+ +++W + +L GYP+D+ S++ FP V+ IDAA++ + KT+FFV +++WRYD
Sbjct: 116 FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDE 175
Query: 401 QRQFMEPGYPKSISGAFPGIESK 423
Q ++ GYPK I PGI K
Sbjct: 176 NMQSVDAGYPKIIDD-LPGISKK 197
>gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]
Length = 198
Score = 95.5 bits (236), Expect = 9e-20
Identities = 52/101 (51%), Positives = 63/101 (62%), Gaps = 7/101 (6%)
Query: 104 GNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAF- 162
G KW+ +NY P L + +V+RA AFELWS AS L FTR + E DI ++F
Sbjct: 19 GIQKWQED------QNYMPNLPQEDVDRATGKAFELWSNASALTFTRDFESEGDIILSFV 72
Query: 163 YQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWT 203
+ D DNSPF G +G LAHAF PG GIGGD HFD +ET T
Sbjct: 73 FLADLHDNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRT 113
Score = 72.8 bits (177), Expect = 6e-13
Identities = 34/83 (40%), Positives = 54/83 (65%), Gaps = 4/83 (4%)
Query: 344 FKGNQYWALSGYDILQGYPKDI-SNYGFPSSVQAIDAAVFYRS--KTYFFVNDQFWRYDN 400
F+ +++W + +L GYP+D+ S++ FP V+ IDAA++ + KT+FFV +++WRYD
Sbjct: 116 FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDE 175
Query: 401 QRQFMEPGYPKSISGAFPGIESK 423
Q ++ GYPK I PGI K
Sbjct: 176 NMQSVDAGYPKIIDD-LPGISKK 197
>gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo
sapiens]
Length = 183
Score = 67.8 bits (164), Expect = 2e-11
Identities = 46/152 (30%), Positives = 71/152 (46%), Gaps = 18/152 (11%)
Query: 35 DYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVP 94
DYL ++ L + + I E L+ Q L V+G+ ++ T M++PRCG+
Sbjct: 30 DYLSQYGYL-QKPLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGLE 88
Query: 95 DSGGFMLTPGNPK---------WERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASP 145
D P N K W + +LT+RI N L A++ AF+ WS +P
Sbjct: 89 D-------PFNQKTLKYLLLGRWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAP 141
Query: 146 LIFTRISQGEADINIAFYQRDHG-DNSPFDGP 176
L F + G ADI ++F+ R ++ FDGP
Sbjct: 142 LTFQEVQAGAADIRLSFHGRQSSYCSNTFDGP 173
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,277,401
Number of Sequences: 37866
Number of extensions: 912519
Number of successful extensions: 2352
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 2085
Number of HSP's gapped (non-prelim): 87
length of query: 467
length of database: 18,247,518
effective HSP length: 106
effective length of query: 361
effective length of database: 14,233,722
effective search space: 5138373642
effective search space used: 5138373642
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.