Search of human proteins with 4505205

Search of human proteins with 4505205

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4505205 matrix metalloproteinase 10 preproprotein [Homo
sapiens]
         (476 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]   992   0.0  
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]    794   0.0  
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H...   502   e-142
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]   480   e-135
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi...   477   e-134
gi|73808268 matrix metalloproteinase 27 [Homo sapiens]                476   e-134
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]    473   e-133
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]      467   e-131
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi...   417   e-117
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]   295   8e-80
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ...   285   6e-77
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]   281   1e-75
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]   276   2e-74
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap...   262   6e-70
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi...   248   9e-66
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]    247   2e-65
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi...   239   3e-63
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot...   230   2e-60
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein...   220   3e-57
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]      216   5e-56
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [...   216   5e-56
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ...   187   2e-47
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi...   185   7e-47
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]   180   3e-45
gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi...   147   2e-35
gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]          102   8e-22
gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]           95   2e-19
gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]           94   2e-19
gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]       93   6e-19
gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ...    85   1e-16

>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
          Length = 476

 Score =  992 bits (2565), Expect = 0.0
 Identities = 476/476 (100%), Positives = 476/476 (100%)

Query: 1   MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV 60
           MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV
Sbjct: 1   MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV 60

Query: 61  KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY 120
           KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY
Sbjct: 61  KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY 120

Query: 121 TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL 180
           TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL
Sbjct: 121 TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL 180

Query: 181 AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN 240
           AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN
Sbjct: 181 AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN 240

Query: 241 SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST 300
           SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST
Sbjct: 241 SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST 300

Query: 301 LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW 360
           LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW
Sbjct: 301 LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW 360

Query: 361 AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG 420
           AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG
Sbjct: 361 AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG 420

Query: 421 FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 476
           FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
Sbjct: 421 FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 476


>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
          Length = 477

 Score =  794 bits (2050), Expect = 0.0
 Identities = 373/477 (78%), Positives = 420/477 (88%), Gaps = 1/477 (0%)

Query: 1   MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQF-RRKDSNLI 59
           M  L  L+LLC+ VCSAYPL GAA+ ED++ +L Q+YLE YY+L+KDVKQF RRKDS  +
Sbjct: 1   MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV 60

Query: 60  VKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVN 119
           VKKI+ MQKFLGLEVTGKLD+DTLEVMRKPRCGVPDVGHF +FPG+PKWRKTHLTYRIVN
Sbjct: 61  VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN 120

Query: 120 YTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHS 179
           YTPDLP+DAVDSA+EKALKVWEEVTPLTFSRLYEGEADIMISFAV+EHGDFY FDGPG+ 
Sbjct: 121 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV 180

Query: 180 LAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLY 239
           LAHAY PGPG+ GD HFDDDE+WT+D +GTNLFLVAAHE+GHSLGLFHSANTEALMYPLY
Sbjct: 181 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY 240

Query: 240 NSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIS 299
           +S T+L +FRLSQDD+NGIQSLYGPPP S E PLVPT+ VP     PA CDPALSFDA+S
Sbjct: 241 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS 300

Query: 300 TLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEF 359
           TLRGE L FKDR+FWR+S    EPE HLIS+FWPSLPS +DAAYEV S+D VFIFKGN+F
Sbjct: 301 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF 360

Query: 360 WAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQ 419
           WAIRGNEV+AGYPRGIHTLGFPPT+RKIDAA+SDKEK KTYFF  DKYWRFDE   SME 
Sbjct: 361 WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP 420

Query: 420 GFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 476
           GFP+ IA+DFPG++ K+DAV + FGFFYFF+GSSQ EFDPNA+ VTH LKSNSWL+C
Sbjct: 421 GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 477


>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
           sapiens]
          Length = 469

 Score =  502 bits (1293), Expect = e-142
 Identities = 246/472 (52%), Positives = 334/472 (70%), Gaps = 16/472 (3%)

Query: 7   LVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQF-RRKDSNLIVKKIQG 65
           L+L    V  ++P +   +E+D   DL Q+YLEKYYNL+ D +Q  +R++S  +V+K++ 
Sbjct: 9   LLLFWGVVSHSFPATLETQEQDV--DLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQ 66

Query: 66  MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLP 125
           MQ+F GL+VTGK D +TL+VM++PRCGVPDV  F    G P+W +THLTYRI NYTPDLP
Sbjct: 67  MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 126

Query: 126 RDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYP 185
           R  VD AIEKA ++W  VTPLTF+++ EG+ADIMISF   +H D   FDGPG +LAHA+ 
Sbjct: 127 RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 186

Query: 186 PGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTEL 245
           PGPG+ GD HFD+DE+WT +    NL  VAAHELGHSLGL HS +  ALMYP   S+T  
Sbjct: 187 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYP---SYTFS 243

Query: 246 AQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEY 305
              +L+QDD++GIQ++YG     ++ P+ P      G + P  CD  L+FDAI+T+RGE 
Sbjct: 244 GDVQLAQDDIDGIQAIYG----RSQNPVQPI-----GPQTPKACDSKLTFDAITTIRGEV 294

Query: 306 LFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGN 365
           +FFKDR++ R + + PE E + IS FWP LP+ L+AAYE   RD V  FKGN++WA++G 
Sbjct: 295 MFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQ 354

Query: 366 EVQAGYPRGIH-TLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRL 424
            V  GYP+ I+ + GFP T++ IDAA+S++   KTYFF A+KYWR+DE  +SM+ G+P++
Sbjct: 355 NVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKM 414

Query: 425 IADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 476
           IA DFPG+  KVDAV    GFFYFF G+ Q++FDP  + +  + K+NSW +C
Sbjct: 415 IAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 466


>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
          Length = 471

 Score =  480 bits (1235), Expect = e-135
 Identities = 237/476 (49%), Positives = 315/476 (66%), Gaps = 13/476 (2%)

Query: 4   LAFLVLLCLPVCSAYPLSGAAKEED-SNKDL--AQQYLEKYYNLEKDVKQFRRKDSNLIV 60
           LA  + L    C A PL     E+D S +DL  A++YL  YY+        +   ++ + 
Sbjct: 6   LAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMT 65

Query: 61  KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY 120
           ++++ MQ F GLEVTGKLD +TL+VM+KPRCGVPDVG ++ FP   KW K +LTYRIVNY
Sbjct: 66  ERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNY 125

Query: 121 TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL 180
           TPD+    V+ A +KA KVW +VTPL F+RL++G ADIMISF +KEHGDFY FDGP   L
Sbjct: 126 TPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLL 185

Query: 181 AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN 240
           AHA+PPGP   GD HFDDDE WT  + G NLFLVAAHE GHSLGL HS +  ALM+P+Y 
Sbjct: 186 AHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIY- 244

Query: 241 SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST 300
           ++T  + F L  DDV GIQSLYGP     E+P       P   + P KCDP+LS DAI++
Sbjct: 245 TYTGKSHFMLPDDDVQGIQSLYGP---GDEDP------NPKHPKTPDKCDPSLSLDAITS 295

Query: 301 LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW 360
           LRGE + FKDR+FWR      + E  L  +FWP LP+ +DAAYE  S D +FIF+G +FW
Sbjct: 296 LRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFW 355

Query: 361 AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG 420
           A+ G ++  GYP+ I  LG P  ++KI AAV  ++  KT  F+ ++ WR+D+ +  M++ 
Sbjct: 356 ALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKD 415

Query: 421 FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 476
           +PRLI +DFPG+  KVDAV +  G+ YFF+G  QFE+   +  +  ++ +NS L C
Sbjct: 416 YPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC 471


>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
           sapiens]
          Length = 470

 Score =  477 bits (1227), Expect = e-134
 Identities = 235/478 (49%), Positives = 318/478 (66%), Gaps = 11/478 (2%)

Query: 2   MHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRK--DSNLI 59
           M    ++LL      A PL+ +   E +N    ++YLEK+Y LE +     +     NL+
Sbjct: 1   MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM 60

Query: 60  VKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVN 119
            +KIQ MQ FLGL+VTG+LDT TLE+M  PRCGVPDV HF   PG P WRK ++TYRI N
Sbjct: 61  KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN 120

Query: 120 YTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHS 179
           YTPD+ R+ VD AI KA +VW  VTPL FS++  G ADI++ FA   HGDF++FDG G  
Sbjct: 121 YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI 180

Query: 180 LAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLY 239
           LAHA+ PG G+ GD HFD+DE WT  + GTNLFL A HE+GHSLGL HS++ +A+M+P Y
Sbjct: 181 LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY 240

Query: 240 NSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIS 299
             + ++  FRLS DD+ GIQSLYG P  +   P       P  SE PA CDP LSFDA++
Sbjct: 241 -KYVDINTFRLSADDIRGIQSLYGDPKENQRLP------NPDNSE-PALCDPNLSFDAVT 292

Query: 300 TLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEF 359
           T+  +  FFKDR+FW +    P+   +LIS+ WP+LPS ++AAYE+ +R+ VF+FK +++
Sbjct: 293 TVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKY 352

Query: 360 WAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQ 419
           W I     +  YP+ IH+ GFP  ++KIDAAV +    +TYFF  ++YWR+DE  Q M+ 
Sbjct: 353 WLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDP 412

Query: 420 GFPRLIADDFPGVEPKVDAVLQAFG-FFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 476
           G+P+LI  +F G+ PK+DAV  +   ++YFF GS+QFE+D   + +T  LKSNSW  C
Sbjct: 413 GYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC 470


>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
          Length = 513

 Score =  476 bits (1226), Expect = e-134
 Identities = 244/478 (51%), Positives = 320/478 (66%), Gaps = 15/478 (3%)

Query: 1   MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQF-RRKDSNLI 59
           M  L  L L  +   SA+PL    + E+ N  LAQ YL ++Y+LE +     + K+ +LI
Sbjct: 1   MKRLLLLFLFFITFSSAFPLVRMTENEE-NMQLAQAYLNQFYSLEIEGNHLVQSKNRSLI 59

Query: 60  VKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVN 119
             KI+ MQ F GL VTGKLD++TLE+M+ PRCGVPDVG +     +P WRK +LTYRI+N
Sbjct: 60  DDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYT--LPGWRKYNLTYRIIN 117

Query: 120 YTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYS-FDGPGH 178
           YTPD+ R AVD AI++ L+VW +VTPL F+++ +G ADIMI+F  + HG     FDGP  
Sbjct: 118 YTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLG 177

Query: 179 SLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPL 238
            L HA+PPGPGL GD HFD+DE WT+D +G NLFLVAAHE GH+LGL HS +  ALM+P 
Sbjct: 178 VLGHAFPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPN 237

Query: 239 YNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAI 298
           Y S  +  ++ LSQDD+NGIQS+YG  P    +P  PT        +P  CDP L+FDAI
Sbjct: 238 YVSL-DPRKYPLSQDDINGIQSIYGGLPKEPAKPKEPT--------IPHACDPDLTFDAI 288

Query: 299 STLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNE 358
           +T R E +FFK R+ WR  +   + EF LI++FWPSLP+ L AAYE N RD + +FK   
Sbjct: 289 TTFRREVMFFKGRHLWRIYYDITDVEFELIASFWPSLPADLQAAYE-NPRDKILVFKDEN 347

Query: 359 FWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSME 418
           FW IRG  V   YP+ IHTLGFP  ++KIDAAV DK  +KTYFF     WRFDE +Q+M+
Sbjct: 348 FWMIRGYAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMD 407

Query: 419 QGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 476
           +GFP+ +   FPG+  +VDA  Q  GFF+F  GS QFE+D   + +T I+++N+W  C
Sbjct: 408 KGFPQRVVKHFPGISIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQC 465


>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
          Length = 467

 Score =  473 bits (1216), Expect = e-133
 Identities = 237/474 (50%), Positives = 316/474 (66%), Gaps = 17/474 (3%)

Query: 4   LAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKD-SNLIVKK 62
           L FL+LL + +  A+P+S   K    N    Q YLEK+Y L  +  Q  RK+ +N+IV+K
Sbjct: 7   LPFLLLLHVQISKAFPVSSKEK----NTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEK 62

Query: 63  IQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTP 122
           ++ MQ+F GL VTGK + +TL++M+KPRCGVPD G F   PG PKW +T+LTYRI NYTP
Sbjct: 63  LKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTP 122

Query: 123 DLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAH 182
            L    V+ AI+ A ++W   +PL F+R+ +GEADI I+F  ++HGD   FDGP   LAH
Sbjct: 123 QLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAH 182

Query: 183 AYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSF 242
           A+ PG G+ GD HFD +E WT  ++  NLFLVAAHE GHSLGL HS++  ALMYP Y +F
Sbjct: 183 AFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNY-AF 241

Query: 243 TELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLR 302
            E + + L QDD++GIQ++YG     +  P+ PT     G   P  CDP+L+FDAI+TLR
Sbjct: 242 RETSNYSLPQDDIDGIQAIYG----LSSNPIQPT-----GPSTPKPCDPSLTFDAITTLR 292

Query: 303 GEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAI 362
           GE LFFKDRYFWRR       E + IS FWPSLP+ + AAYE   RD +F+FKGN++WA+
Sbjct: 293 GEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWAL 352

Query: 363 RGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFP 422
            G ++  GYP+ I   GFP +++ IDAAV    + KTYFF  D++WR+D   Q ME G+P
Sbjct: 353 SGYDILQGYPKDISNYGFPSSVQAIDAAVF--YRSKTYFFVNDQFWRYDNQRQFMEPGYP 410

Query: 423 RLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 476
           + I+  FPG+E KVDAV Q   FF+ FSG   + FD  A+ VT + + N WL+C
Sbjct: 411 KSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNC 464


>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
          Length = 403

 Score =  467 bits (1201), Expect = e-131
 Identities = 223/412 (54%), Positives = 295/412 (71%), Gaps = 13/412 (3%)

Query: 66  MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLP 125
           MQ+F GL+VTGK D +TL+VM++PRCGVPDV  F    G P+W +THLTYRI NYTPDLP
Sbjct: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60

Query: 126 RDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYP 185
           R  VD AIEKA ++W  VTPLTF+++ EG+ADIMISF   +H D   FDGPG +LAHA+ 
Sbjct: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120

Query: 186 PGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTEL 245
           PGPG+ GD HFD+DE+WT +    NL  VAAHELGHSLGL HS +  ALMYP   S+T  
Sbjct: 121 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYP---SYTFS 177

Query: 246 AQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEY 305
              +L+QDD++GIQ++YG     ++ P+ P      G + P  CD  L+FDAI+T+RGE 
Sbjct: 178 GDVQLAQDDIDGIQAIYG----RSQNPVQPI-----GPQTPKACDSKLTFDAITTIRGEV 228

Query: 306 LFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGN 365
           +FFKDR++ R + + PE E + IS FWP LP+ L+AAYE   RD V  FKGN++WA++G 
Sbjct: 229 MFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQ 288

Query: 366 EVQAGYPRGIH-TLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRL 424
            V  GYP+ I+ + GFP T++ IDAA+S++   KTYFF A+KYWR+DE  +SM+ G+P++
Sbjct: 289 NVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKM 348

Query: 425 IADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 476
           IA DFPG+  KVDAV    GFFYFF G+ Q++FDP  + +  + K+NSW +C
Sbjct: 349 IAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 400


>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
           sapiens]
          Length = 483

 Score =  417 bits (1073), Expect = e-117
 Identities = 218/478 (45%), Positives = 297/478 (62%), Gaps = 8/478 (1%)

Query: 4   LAFLVLLCLPVCSAYPLSGAAKEED--SNKDLAQQYLEKYYNLEK--DVKQFRRKDSNLI 59
           LA  +++ L   +A P   AA      +N  LAQ YL+KYY  ++   + +   + SN +
Sbjct: 9   LAVFLIMALKFSTAAPSLVAASPRTWRNNYRLAQAYLDKYYTNKEGHQIGEMVARGSNSM 68

Query: 60  VKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVN 119
           ++KI+ +Q F GL+VTGKLD  T+ V++KPRCGVPDV ++  FPG PKW+K  LTYRI  
Sbjct: 69  IRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANYRLFPGEPKWKKNTLTYRISK 128

Query: 120 YTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHS 179
           YTP +    VD A+E AL+ W    PL+F R+  GEADIMISF   +HGD Y FDGP  +
Sbjct: 129 YTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDSYPFDGPRGT 188

Query: 180 LAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLY 239
           LAHA+ PG GL GD HFD+ EKWT   +G NLF VAAHE GH+LGL HS +  ALMYP Y
Sbjct: 189 LAHAFAPGEGLGGDTHFDNAEKWTMGTNGFNLFTVAAHEFGHALGLAHSTDPSALMYPTY 248

Query: 240 NSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIS 299
             +     F L +DDV GIQ+LYGP      +P +P       S +P  CD + SFDA++
Sbjct: 249 -KYKNPYGFHLPKDDVKGIQALYGPRKVFLGKPTLPHAPHHKPS-IPDLCDSSSSFDAVT 306

Query: 300 TLRGEYLFFKDRYFWRRS-HWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNE 358
            L  E L FKDR FWRR  H         I++ +P L S +DAAYEV  R T + FKG  
Sbjct: 307 MLGKELLLFKDRIFWRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPH 366

Query: 359 FWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSME 418
           +W  RG ++Q G PR I+  GFP  +++IDAAV  +E +KT FF  D+Y+ +DE  + ME
Sbjct: 367 YWITRGFQMQ-GPPRTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKRKME 425

Query: 419 QGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 476
           + +P+   ++F GV  ++DA ++  G+ YFFSG   +++D     V  ++KS+SW+ C
Sbjct: 426 KDYPKNTEEEFSGVNGQIDAAVELNGYIYFFSGPKTYKYDTEKEDVVSVVKSSSWIGC 483


>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
          Length = 645

 Score =  295 bits (754), Expect = 8e-80
 Identities = 184/491 (37%), Positives = 254/491 (51%), Gaps = 53/491 (10%)

Query: 16  SAYPLSGAAKEEDSNKDLAQQYLEKY-YNLEKDVKQFRRKDSNLIVKKIQGMQKFLGLEV 74
           +A  ++ A  +E       Q +L+ Y Y L  D +      +  +   +  MQ+F G+ V
Sbjct: 63  AAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPV 122

Query: 75  TGKLDTDTLEVMRKPRCGVPDVGHFS--------SFPGMPKWRKTHLTYRIVNYTPDLPR 126
           TG LD  T+E M+KPRCGVPD  H S        +  G  KWR+ H+TY I NYTP +  
Sbjct: 123 TGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQ-KWRQKHITYSIHNYTPKVGE 181

Query: 127 DAVDSAIEKALKVWEEVTPLTFSRLY-------EGEADIMISFAVKEHGDFYSFDGPGHS 179
                AI +A  VW++VTPLTF  +          EADIMI FA   HGD   FDG G  
Sbjct: 182 LDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGF 241

Query: 180 LAHAYPPGPGLYGDIHFDDDEKWT---EDASGTNLFLVAAHELGHSLGLFHSANTEALMY 236
           LAHAY PGPG+ GD HFD DE WT    +  G +LFLVA HELGH+LGL HS++  A+M 
Sbjct: 242 LAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMA 301

Query: 237 PLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEE----PLVPTKSVPSGSEM------- 285
           P Y  + E   F+L QDD+ GIQ +YGPP    E     P +P + + S SE        
Sbjct: 302 PFYQ-YMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPR 360

Query: 286 ----------------PAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHWNPEPEFHL-I 328
                           P  CD   +F+ ++  RGE   FKDR+FWR  +   +  + + I
Sbjct: 361 PPRPPLGDRPSTPGTKPNICDG--NFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQI 418

Query: 329 SAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKID 388
             FW  LP+ +DAAYE      VF FKG+++W  +   V+ GYP  +  LG       ID
Sbjct: 419 EQFWKGLPARIDAAYERADGRFVF-FKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGID 477

Query: 389 AAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVLQAFGFF-Y 447
            A+  +   KTYFF  ++YWR+ E  ++ + G+P+ I       +    A +   G++ Y
Sbjct: 478 TALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTY 537

Query: 448 FFSGSSQFEFD 458
           F+ G   ++FD
Sbjct: 538 FYKGRDYWKFD 548


>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
           [Homo sapiens]
          Length = 607

 Score =  285 bits (729), Expect = 6e-77
 Identities = 186/502 (37%), Positives = 261/502 (51%), Gaps = 67/502 (13%)

Query: 7   LVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKY-YNLEKDVKQFRRKDSNLIVKKIQG 65
           L +LC  VC          E+  N ++   +L+KY Y    D +    + +  +   +  
Sbjct: 27  LWILCATVCGT--------EQYFNVEV---WLQKYGYLPPTDPRMSVLRSAETMQSALAA 75

Query: 66  MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSS----------FPGMPKWRKTHLTY 115
           MQ+F G+ +TGK+D +T++ M+KPRCGVPD    SS            G  KW+  H+TY
Sbjct: 76  MQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQ-KWQHKHITY 134

Query: 116 RIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTF-----SRLYEG--EADIMISFAVKEHG 168
            I N TP +       AI +A  VW+ VTPLTF     S L  G  + DI I FA   HG
Sbjct: 135 SIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHG 194

Query: 169 DFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWT---EDASGTNLFLVAAHELGHSLGL 225
           D   FDG G  LAHAY PGPG+ GD HFD DE WT    +  G +LFLVA HELGH+LGL
Sbjct: 195 DSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGL 254

Query: 226 FHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPP----PASTEEPLVPT-KSVP 280
            HS +  A+M P Y  + E   F+L  DD+ GIQ +YGPP    P +   P VP  +S+P
Sbjct: 255 EHSNDPTAIMAPFYQ-YMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIP 313

Query: 281 SGSEM---------------------PAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHW 319
                                     P  CD   +F+ ++ LR E   FKD++FWR  + 
Sbjct: 314 PADPRKNDRPKPPRPPTGRPSYPGAKPNICDG--NFNTLAILRREMFVFKDQWFWRVRNN 371

Query: 320 NPEPEFHL-ISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTL 378
                + + I+ FW  LP  +DA YE +  + VF FKGN++W  +   +Q GYP  + TL
Sbjct: 372 RVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVF-FKGNKYWVFKDTTLQPGYPHDLITL 430

Query: 379 GFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGV--EPKV 436
           G       ID+A+  ++  KTYFF  D+YWR+ E  ++M+ G+P+ I   + G+   P+ 
Sbjct: 431 GSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPIT-VWKGIPESPQG 489

Query: 437 DAVLQAFGFFYFFSGSSQFEFD 458
             V +  GF YF+ G   ++F+
Sbjct: 490 AFVHKENGFTYFYKGKEYWKFN 511


>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
          Length = 582

 Score =  281 bits (718), Expect = 1e-75
 Identities = 181/484 (37%), Positives = 255/484 (52%), Gaps = 42/484 (8%)

Query: 10  LCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKY-YNLEKDVKQFRRKDSNLIVKKIQGMQK 68
           L LP+ +      +     S+    + +L++Y Y    D++   ++    +   I  MQK
Sbjct: 11  LLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQK 70

Query: 69  FLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFS----------SFPGMPKWRKTHLTYRIV 118
           F GL+VTGK D DT++ MR+PRCGVPD               +  G+ KW+   +T+ I 
Sbjct: 71  FYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGL-KWQHNEITFCIQ 129

Query: 119 NYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRL--------YEGEADIMISFAVKEHGDF 170
           NYTP +   A   AI KA +VWE  TPL F  +        +E +ADIMI FA   HGD 
Sbjct: 130 NYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDS 189

Query: 171 YSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWT---EDASGTNLFLVAAHELGHSLGLFH 227
             FDG G  LAHAY PGP + GD HFD  E WT   ED +G ++FLVA HELGH+LGL H
Sbjct: 190 TPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEH 249

Query: 228 SANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYG----------PPPASTEEPLVPTK 277
           S++  A+M P Y  + +   F L  DD  GIQ LYG          P P +T  P VP K
Sbjct: 250 SSDPSAIMAPFY-QWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDK 308

Query: 278 SVPSGSEMPAKCDPALSFDAISTLRGEYLFFKDRYFWR-RSHWNPEPEFHLISAFWPSLP 336
              + +  P  CD   +FD ++ LRGE   FK+R+FWR R++   +     I  FW  LP
Sbjct: 309 P-KNPTYGPNICDG--NFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLP 365

Query: 337 SYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEK 396
           + ++ AYE      VF FKG++ W      ++ GYP+ I  LG      KIDAA+     
Sbjct: 366 ASINTAYERKDGKFVF-FKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPN 424

Query: 397 KKTYFFAADKYWRFDENSQSMEQGFPRLIA--DDFPGVEPKVDAVLQAFGFFYFFSGSSQ 454
            KTYFF  +KY+RF+E  ++++  +P+ I   +  P   P+   +     F YF+ G+  
Sbjct: 425 GKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIP-ESPRGSFMGSDEVFTYFYKGNKY 483

Query: 455 FEFD 458
           ++F+
Sbjct: 484 WKFN 487


>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
          Length = 669

 Score =  276 bits (707), Expect = 2e-74
 Identities = 183/516 (35%), Positives = 253/516 (49%), Gaps = 70/516 (13%)

Query: 7   LVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRR-KDSNLIVKKIQG 65
           L+ L L +     L  AA++ + +   A+ +L  Y  L +  +     + + ++   +  
Sbjct: 29  LLPLLLVLLGCLGLGVAAEDAEVH---AENWLRLYGYLPQPSRHMSTMRSAQILASALAE 85

Query: 66  MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMP-----------KWRKTHLT 114
           MQ+F G+ VTG LD +T E M++PRCGVPD         +            KW   HLT
Sbjct: 86  MQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLT 145

Query: 115 YRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRL-YEG-------EADIMISFAVKE 166
           + I NYT  L       A+ +A +VWE+ TPL F  + YE        EADIM+ FA   
Sbjct: 146 FSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGF 205

Query: 167 HGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWT---EDASGTNLFLVAAHELGHSL 223
           HGD   FDG G  LAHAY PGPGL GD HFD DE WT    D  G NLFLVA HELGH+L
Sbjct: 206 HGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHAL 265

Query: 224 GLFHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYG-------------------- 263
           GL HS+N  A+M P Y  + ++  F+L +DD+ GIQ LYG                    
Sbjct: 266 GLEHSSNPNAIMAPFY-QWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRP 324

Query: 264 --------------PPPASTEEPLVPTKSV-PSGSEMPAKCDPAL---SFDAISTLRGEY 305
                         PP    E P  P   V P  +E P +  P +    FD ++ LRGE 
Sbjct: 325 GRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAMLRGEM 384

Query: 306 LFFKDRYFWRRSHWNPEPEFHL-ISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRG 364
             FK R+FWR  H      + + I  FW  LP  + AAYE      VF FKG+ +W  R 
Sbjct: 385 FVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVF-FKGDRYWLFRE 443

Query: 365 NEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRL 424
             ++ GYP+ + + G      +ID A+  +    T+FF  D+YWRF+E +Q  + G+P+ 
Sbjct: 444 ANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKP 503

Query: 425 IA--DDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFD 458
           I+     P   PK   +     + YF+ G+  ++FD
Sbjct: 504 ISVWQGIP-ASPKGAFLSNDAAYTYFYKGTKYWKFD 538


>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
           sapiens]
          Length = 603

 Score =  262 bits (669), Expect = 6e-70
 Identities = 163/431 (37%), Positives = 228/431 (52%), Gaps = 45/431 (10%)

Query: 61  KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSF------PGMPKWRKTHLT 114
           K I  MQ+F GLE TG LD  TL +M+ PRC +PD+   +        P   KW K +L+
Sbjct: 80  KAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLS 139

Query: 115 YRIVNYTPDLP--RDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYS 172
           +R+  +  D P   D V + +  ALKVW ++ PL F  +    ADI I F+  +H D Y 
Sbjct: 140 WRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYP 199

Query: 173 FDGPGHSLAHAYPPG-PGLYGDIHFDDDEKWT---EDASGTNLFLVAAHELGHSLGLFHS 228
           FDGPG ++AHA+ PG     GD HFDDDE WT    DA G +LF VA HE GH++GL H 
Sbjct: 200 FDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHV 259

Query: 229 ANTEALMYPLYNS-FTELAQFRLSQDDVNGIQSLYG-----PPPASTEE-PLVP-----T 276
           A   ++M P Y     +  ++ L  +D   +  LYG      P A  EE PL+P      
Sbjct: 260 AAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNR 319

Query: 277 KSVPSGSEMPAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHWNPEPEFHLIS------- 329
            S P   ++P +C  +  FDA++ +RGE  FFK +YFWR +      + HL+S       
Sbjct: 320 SSAPPRKDVPHRC--STHFDAVAQIRGEAFFFKGKYFWRLTR-----DRHLVSLQPAQMH 372

Query: 330 AFWPSLPSYL---DAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRK 386
            FW  LP +L   DA YE  S   +  FKG+ +W  + N V+ GYPR +     PP    
Sbjct: 373 RFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPP--GG 430

Query: 387 IDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKV-DAVLQAFGF 445
           IDAA S     +TYFF    YWR+D++++ M+ G+P   +  + GV   + DA+  + G 
Sbjct: 431 IDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQ-SPLWRGVPSTLDDAMRWSDGA 489

Query: 446 FYFFSGSSQFE 456
            YFF G   ++
Sbjct: 490 SYFFRGQEYWK 500


>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
           sapiens]
          Length = 488

 Score =  248 bits (633), Expect = 9e-66
 Identities = 161/396 (40%), Positives = 210/396 (53%), Gaps = 32/396 (8%)

Query: 86  MRKPRCGVPDVGHFSSFPGMPK--------WRKTHLTYRIVNYTPDLPRDAVDSAIEKAL 137
           +R PRCGVPD     S     K        W KT LTYRI+ +   L ++ V   + +AL
Sbjct: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEAL 134

Query: 138 KVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFD 197
           KVW +VTPLTF+ ++EG ADIMI FA   HGD   FDGPG  LAHA+ P     GD+HFD
Sbjct: 135 KVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFD 194

Query: 198 DDEKWT-EDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQDDVN 256
            DE WT  D  GT+L  VAAHE GH LGL H+   +ALM   Y     L+   LS DD  
Sbjct: 195 YDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS---LSPDDCR 251

Query: 257 GIQSLYG---PPPASTEEPLVPTKSVPSGSEMPAKCDP-----ALSFDAISTLRGEYLFF 308
           G+Q LYG   P   S    L P   + +    P + D        SFDA+ST+RGE  FF
Sbjct: 252 GVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFF 311

Query: 309 KDRYFWRRSHWNPEPEF-HLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEV 367
           K  + WR      +P +  L S  W  LPS +DAA+E +++  ++ F+G ++W   G + 
Sbjct: 312 KAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFE-DAQGHIWFFQGAQYWVYDGEKP 370

Query: 368 QAGYPRGIHTLG---FPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRL 424
             G P  +  LG   FP       A V   EK K YFF    YWRF  +++ ++   PR 
Sbjct: 371 VLG-PAPLTELGLVRFPVHA----ALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRR 425

Query: 425 IADDFPGVEPKVDAVLQ-AFGFFYFFSGSSQFEFDP 459
            A D+ GV  ++DA  Q A G+ YF  G   ++FDP
Sbjct: 426 -ATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDP 460


>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
          Length = 267

 Score =  247 bits (630), Expect = 2e-65
 Identities = 128/265 (48%), Positives = 170/265 (64%), Gaps = 9/265 (3%)

Query: 2   MHLAFLVLLCL-PVCSAYPL-SGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLI 59
           M L  L  +CL P   A PL   A    +   + AQ YL+++Y  + + K     ++N +
Sbjct: 1   MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETK-----NANSL 55

Query: 60  VKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVN 119
             K++ MQKF GL +TG L++  +E+M+KPRCGVPDV  +S FP  PKW    +TYRIV+
Sbjct: 56  EAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVS 115

Query: 120 YTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHS 179
           YT DLP   VD  + KAL +W +  PL F ++  G ADIMI FA   HGD Y FDGPG++
Sbjct: 116 YTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNT 175

Query: 180 LAHAYPPGPGLYGDIHFDDDEKWTEDAS-GTNLFLVAAHELGHSLGLFHSANTEALMYPL 238
           LAHA+ PG GL GD HFD+DE+WT+ +S G N    A HELGHSLG+ HS++  A+MYP 
Sbjct: 176 LAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPT 235

Query: 239 YNSFTELAQFRLSQDDVNGIQSLYG 263
           Y +  +   F+LSQDD+ GIQ LYG
Sbjct: 236 YGN-GDPQNFKLSQDDIKGIQKLYG 259


>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
           sapiens]
          Length = 562

 Score =  239 bits (611), Expect = 3e-63
 Identities = 168/496 (33%), Positives = 249/496 (50%), Gaps = 51/496 (10%)

Query: 7   LVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKY-YNLEKDVKQFRRKDSNLIVKKIQG 65
           L LL L +    P + A K    +  L   +L +Y Y       Q + +    +   I+ 
Sbjct: 5   LRLLALLLLLLAPPARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRDAIKV 64

Query: 66  MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPK--------WRKTHLTYRI 117
           MQ+F GL  TG++D  T+  MRKPRC +PDV   +      +        W+K  LT+R+
Sbjct: 65  MQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTWRV 124

Query: 118 VNY--TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEG---EADIMISFAVKEHGDFYS 172
            ++  +  L ++ V   +  AL  W   + LTF  +      E DI+I FA   H D Y 
Sbjct: 125 RSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDSYP 184

Query: 173 FDGPGHSLAHAYPPGPG-LYGDIHFDDDEKWT---EDASGTNLFLVAAHELGHSLGLFHS 228
           FDG G +LAHA+ PG   + GD HFDD+E WT   +D  GT+LF VA HE GH+LGL HS
Sbjct: 185 FDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHS 244

Query: 229 ANTEALMYPLYNS-FTELAQFRLSQDDVNGIQSLYGPPPAS-----TEEPLVPTKSVPSG 282
           +   ++M P Y     +  ++RLSQDD +G+Q LYG  P +     T +PL P    P+ 
Sbjct: 245 SAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPAS 304

Query: 283 S------EMPAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHWNPEPEFHLIS------- 329
                   +P +C+   +FDAI+ +RGE  FFK  +FWR      +P   L+S       
Sbjct: 305 PTHSPSFPIPDRCEG--NFDAIANIRGETFFFKGPWFWRL-----QPSGQLVSPRPARLH 357

Query: 330 AFWPSLPS---YLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRK 386
            FW  LP+    + AAY  +    + +F G +FW  +  +++ G  R +  LG PP   +
Sbjct: 358 RFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGG-ARPLTELGLPPG-EE 415

Query: 387 IDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAV-LQAFGF 445
           +DA  S  +  KTY     +YWR+DE +   + G+PR ++  + G  P  D V +   G 
Sbjct: 416 VDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLS-LWEGAPPSPDDVTVSNAGD 474

Query: 446 FYFFSGSSQFEFDPNA 461
            YFF G+  + F  N+
Sbjct: 475 TYFFKGAHYWRFPKNS 490


>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
           [Homo sapiens]
          Length = 508

 Score =  230 bits (586), Expect = 2e-60
 Identities = 156/456 (34%), Positives = 229/456 (50%), Gaps = 30/456 (6%)

Query: 37  YLEKYYNLEKDVKQFRRKDSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDV 96
           YL +Y  L+K ++         I + ++  Q+   L V+G+LD  T   MR+PRCG+ D 
Sbjct: 31  YLSQYGYLQKPLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGLEDP 90

Query: 97  GHFSSFPGM--PKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEG 154
            +  +   +   +WRK HLT+RI+N    LP     +A+ +A + W  V PLTF  +  G
Sbjct: 91  FNQKTLKYLLLGRWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPLTFQEVQAG 150

Query: 155 EADIMISFAVKEHG-DFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDA-SGTNLF 212
            ADI +SF  ++      +FDGPG  LAHA  P     G +HFD+DE WTE    G NL 
Sbjct: 151 AADIRLSFHGRQSSYCSNTFDGPGRVLAHADIPE---LGSVHFDEDEFWTEGTYRGVNLR 207

Query: 213 LVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYG--------P 264
           ++AAHE+GH+LGL HS  ++ALM P+Y  +     F+L  DDV GIQ+LYG         
Sbjct: 208 IIAAHEVGHALGLGHSRYSQALMAPVYEGYR--PHFKLHPDDVAGIQALYGKKSPVIRDE 265

Query: 265 PPASTEEPLVPTKSVPS-GSEMPAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHWNPEP 323
               TE P VP   VP+  S MP  C   L    +   RG+   FK  Y W  S   P P
Sbjct: 266 EEEETELPTVP--PVPTEPSPMPDPCSSELDAMMLGP-RGKTYAFKGDYVWTVSDSGPGP 322

Query: 324 EFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPT 383
            F  +SA W  LP  LDAA        +  FKG++ W     ++  G+P+ ++ +     
Sbjct: 323 LFR-VSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKLNRVE---- 377

Query: 384 IRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVLQ-A 442
              +DAA+     +K + F    YW++DE +++    +P+ I   F GV  +  A +   
Sbjct: 378 -PNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQ 436

Query: 443 FGFFYFFSGSSQFEFDPNARMVTHILK--SNSWLHC 476
            G  YFF G   +  +   R+     +  S++W+HC
Sbjct: 437 DGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHC 472


>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
           [Homo sapiens]
          Length = 457

 Score =  220 bits (560), Expect = 3e-57
 Identities = 158/442 (35%), Positives = 215/442 (48%), Gaps = 67/442 (15%)

Query: 7   LVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKY-YNLEKDVKQFRRKDSNLIVKKIQG 65
           L +LC  VC          E+  N ++   +L+KY Y    D +    + +  +   +  
Sbjct: 27  LWILCATVCGT--------EQYFNVEV---WLQKYGYLPPTDPRMSVLRSAETMQSALAA 75

Query: 66  MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSS----------FPGMPKWRKTHLTY 115
           MQ+F G+ +TGK+D +T++ M+KPRCGVPD    SS            G  KW+  H+TY
Sbjct: 76  MQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQ-KWQHKHITY 134

Query: 116 RIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTF-----SRLYEG--EADIMISFAVKEHG 168
            I N TP +       AI +A  VW+ VTPLTF     S L  G  + DI I FA   HG
Sbjct: 135 SIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHG 194

Query: 169 DFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWT---EDASGTNLFLVAAHELGHSLGL 225
           D   FDG G  LAHAY PGPG+ GD HFD DE WT    +  G +LFLVA HELGH+LGL
Sbjct: 195 DSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGL 254

Query: 226 FHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGP----PPASTEEPLVPT-KSVP 280
            HS +  A+M P Y  + E   F+L  DD+ GIQ +YGP    PP +   P VP  +S+P
Sbjct: 255 EHSNDPTAIMAPFY-QYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIP 313

Query: 281 SG---------------------SEMPAKCDPALSFDAISTLRGEYLFFKDRYFWR-RSH 318
                                     P  CD   +F+ ++ LR E   FKD++FWR R++
Sbjct: 314 PADPRKNDRPKPPRPPTGRPSYPGAKPNICDG--NFNTLAILRREMFVFKDQWFWRVRNN 371

Query: 319 WNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTL 378
              +     I+ FW  LP  +DA YE +  + VF     +  +I    +Q G+    H  
Sbjct: 372 RVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKVKGDTLSI----IQDGWLYKYHWK 427

Query: 379 GFPPTIRKIDAAVSDKEKKKTY 400
                 + +       EK KTY
Sbjct: 428 WILEQRQSVPVLSRQTEKHKTY 449


>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
          Length = 610

 Score =  216 bits (549), Expect = 5e-56
 Identities = 118/287 (41%), Positives = 165/287 (57%), Gaps = 11/287 (3%)

Query: 195 HFDDDEKWTE-DASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQD 253
           ++DDD KW      G +LFLVAAHE GH++GL HS +  ALM P+Y   T    FRLSQD
Sbjct: 330 NYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIY---TYTKNFRLSQD 386

Query: 254 DVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEYLFFKDRYF 313
           D+ GIQ LYG  P   +    PT ++  G   P  C   + FD I+ +RGE  FFKDR+ 
Sbjct: 387 DIKGIQELYGASP-DIDLGTGPTPTL--GPVTPEICKQDIVFDGIAQIRGEIFFFKDRFI 443

Query: 314 WRRSHWNPEPEFHLISA-FWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYP 372
           WR      +P   L+ A FWP LP  +DA YE    +    F GNE+W    + ++ GYP
Sbjct: 444 WRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYP 503

Query: 373 RGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGV 432
           + + +LG PP ++++DAA +  + KKTY FA DK+WR++E  + M+ GFP+LIAD +  +
Sbjct: 504 KPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAI 563

Query: 433 EPKVDAV--LQAFGFFYFFSGSSQFEFD-PNARMVTHILKSNSWLHC 476
              +DAV  LQ  G  YFF G+   + +  + + V      + WL C
Sbjct: 564 PDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 610



 Score =  187 bits (476), Expect = 1e-47
 Identities = 92/170 (54%), Positives = 113/170 (66%), Gaps = 9/170 (5%)

Query: 36  QYLEKYYNLEKDVKQFRRKDSNLIVKK--IQGMQKFLGLEVTGKLDTDTLEVMRKPRCGV 93
           QYL  +Y   K+         NL V K  ++ MQKF GL  TG LD +T+E MRKPRCG 
Sbjct: 2   QYLNTFYGCPKE-------SCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGN 54

Query: 94  PDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYE 153
           PDV +++ FP  PKW K  +TYRI+ YTPDL  + VD A  +A +VW +VTPL FSR+++
Sbjct: 55  PDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHD 114

Query: 154 GEADIMISFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWT 203
           GEADIMI+F   EHGD Y FDG    LAHA+ PG G+ GD HFDDDE WT
Sbjct: 115 GEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWT 164


>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
           [Homo sapiens]
          Length = 660

 Score =  216 bits (549), Expect = 5e-56
 Identities = 118/287 (41%), Positives = 165/287 (57%), Gaps = 11/287 (3%)

Query: 195 HFDDDEKWTE-DASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQD 253
           ++DDD KW      G +LFLVAAHE GH++GL HS +  ALM P+Y   T    FRLSQD
Sbjct: 380 NYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIY---TYTKNFRLSQD 436

Query: 254 DVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEYLFFKDRYF 313
           D+ GIQ LYG  P   +    PT ++  G   P  C   + FD I+ +RGE  FFKDR+ 
Sbjct: 437 DIKGIQELYGASP-DIDLGTGPTPTL--GPVTPEICKQDIVFDGIAQIRGEIFFFKDRFI 493

Query: 314 WRRSHWNPEPEFHLISA-FWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYP 372
           WR      +P   L+ A FWP LP  +DA YE    +    F GNE+W    + ++ GYP
Sbjct: 494 WRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYP 553

Query: 373 RGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGV 432
           + + +LG PP ++++DAA +  + KKTY FA DK+WR++E  + M+ GFP+LIAD +  +
Sbjct: 554 KPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAI 613

Query: 433 EPKVDAV--LQAFGFFYFFSGSSQFEFD-PNARMVTHILKSNSWLHC 476
              +DAV  LQ  G  YFF G+   + +  + + V      + WL C
Sbjct: 614 PDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 660



 Score =  193 bits (491), Expect = 3e-49
 Identities = 95/177 (53%), Positives = 119/177 (67%), Gaps = 9/177 (5%)

Query: 29  SNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIVKK--IQGMQKFLGLEVTGKLDTDTLEVM 86
           ++K+LA QYL  +Y   K+         NL V K  ++ MQKF GL  TG LD +T+E M
Sbjct: 45  TDKELAVQYLNTFYGCPKE-------SCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETM 97

Query: 87  RKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPL 146
           RKPRCG PDV +++ FP  PKW K  +TYRI+ YTPDL  + VD A  +A +VW +VTPL
Sbjct: 98  RKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPL 157

Query: 147 TFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWT 203
            FSR+++GEADIMI+F   EHGD Y FDG    LAHA+ PG G+ GD HFDDDE WT
Sbjct: 158 RFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWT 214


>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 520

 Score =  187 bits (474), Expect = 2e-47
 Identities = 149/467 (31%), Positives = 209/467 (44%), Gaps = 55/467 (11%)

Query: 34  AQQYLEKYYNLEKDVKQFRRKDSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGV 93
           A+ +LEKY  L + V   +   S      I+  Q    L V+G LD  TL  M +PRCGV
Sbjct: 36  AEAFLEKYGYLNEQVP--KAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGV 93

Query: 94  PDVGHFSSFPGM----------------------PKWRKTHLTYRIVNYTPDLPRDAVDS 131
            D   ++++                          KW K HL+YR+VN+   LP  AV  
Sbjct: 94  TDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRG 153

Query: 132 AIEKALKVWEEVTPLTF-SRLYEGEADIMISFAVKEHGDFY--SFDGPGHSLAHAYPPGP 188
           A+  A ++W  V+ L F      G ADI ++F   +H D    +FDGPG +LAHA+ P  
Sbjct: 154 AVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLP-- 211

Query: 189 GLYGDIHFDDDEKWT-EDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQ 247
              G+ HFD DE+W+     G NLF+V AHE+GH+LGL HS    ALM P Y      A 
Sbjct: 212 -RRGEAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDA- 269

Query: 248 FRLSQDDVNGIQSLYGPPPASTEEPLVPTKSV----------PSG----SEMPAKCDPAL 293
             LS DDV  +QSLYG P   +    +P K            P G    ++ P  C    
Sbjct: 270 -LLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPKYCHS-- 326

Query: 294 SFDAISTLRGEYLF-FKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVF 352
           SFDAI+  R + L+ FK  +FW  +      E   +   W  LP  ++AA    +    +
Sbjct: 327 SFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQERWVGLPPNIEAAAVSLNDGDFY 386

Query: 353 IFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDE 412
            FKG   W  RG +   G P+     G P   R  DAA+     ++   F   +Y+    
Sbjct: 387 FFKGGRCWRFRGPKPVWGLPQLCRAGGLP---RHPDAALFFPPLRRLILFKGARYYVLAR 443

Query: 413 NSQSMEQGFPRLIADDFPGVEPKVDAVL-QAFGFFYFFSGSSQFEFD 458
               +E  +PR +  D+ G+  +V   L +  G   FF     +  D
Sbjct: 444 GGLQVEPYYPRSL-QDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLD 489


>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
           sapiens]
          Length = 261

 Score =  185 bits (470), Expect = 7e-47
 Identities = 108/265 (40%), Positives = 147/265 (55%), Gaps = 15/265 (5%)

Query: 2   MHLAFL-VLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV 60
           M L  L V + LP C A P+  AA  +    D  + Y  +++          +K+S L+ 
Sbjct: 1   MQLVILRVTIFLPWCFAVPVPPAA--DHKGWDFVEGYFHQFF--------LTKKESPLLT 50

Query: 61  KKIQG--MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIV 118
           ++ Q   +Q+F     T  LD     ++ +P CGVPD    S  PG  KW K  LTYRI+
Sbjct: 51  QETQTQLLQQF-HRNGTDLLDMQMHALLHQPHCGVPDGSDTSISPGRCKWNKHTLTYRII 109

Query: 119 NYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGH 178
           NY  D+   AV  +I  A+ +W  VTPL F ++  G+ADI +SF    H D + FDGPG 
Sbjct: 110 NYPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQVQNGDADIKVSFWQWAHEDGWPFDGPGG 169

Query: 179 SLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPL 238
            L HA+ P  G  G +HFD +E W+   +G NLFLVA HE+GHSLGL HS N  ++MYP 
Sbjct: 170 ILGHAFLPNSGNPGVVHFDKNEHWSASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPT 229

Query: 239 YNSFTELAQFRLSQDDVNGIQSLYG 263
           Y  + +   F+LS DD+  IQ LYG
Sbjct: 230 Y-WYHDPRTFQLSADDIQRIQHLYG 253


>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
          Length = 707

 Score =  180 bits (456), Expect = 3e-45
 Identities = 95/207 (45%), Positives = 126/207 (60%), Gaps = 14/207 (6%)

Query: 7   LVLLCLPVCSAYP---------LSGAAKEEDSNKDLAQQYLEKY-YNLEKDVKQFRRKDS 56
           LVLL L  C A P           G  +   +++ LA++YL +Y Y    ++    R +S
Sbjct: 9   LVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEM----RGES 64

Query: 57  NLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYR 116
             +   +  +QK L L  TG+LD+ TL+ MR PRCGVPD+G F +F G  KW   ++TY 
Sbjct: 65  KSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYW 124

Query: 117 IVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGP 176
           I NY+ DLPR  +D A  +A  +W  VTPLTF+R+Y  +ADI+I F V EHGD Y FDG 
Sbjct: 125 IQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGK 184

Query: 177 GHSLAHAYPPGPGLYGDIHFDDDEKWT 203
              LAHA+PPGPG+ GD HFDDDE W+
Sbjct: 185 DGLLAHAFPPGPGIQGDAHFDDDELWS 211



 Score =  126 bits (317), Expect = 4e-29
 Identities = 100/303 (33%), Positives = 136/303 (44%), Gaps = 56/303 (18%)

Query: 195 HFDDDEKWTE-DASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQD 253
           +FD D+KW      G +LFLVAAHE GH+LGL HS+  EALMYP+Y  FTE     L +D
Sbjct: 378 NFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYR-FTEGPP--LHKD 434

Query: 254 DVNGIQSLYG--------PPPASTEEPLVPTKSVPSG------SEMP------------- 286
           DVNGI+ LYG        PP  +T +P  P    P+G      SE P             
Sbjct: 435 DVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPT 494

Query: 287 ---------------AKCDPALS---FDAISTLRGEYLFFKDRYFWRRSHW---NPEPEF 325
                          +  D A +   FDAI+ +  +   FKD  +WR S      P+  F
Sbjct: 495 GPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQGPF 554

Query: 326 HLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIR 385
            LI+  WP+LP  LD+ +E      +F F G + W   G  V    PR +  LG    + 
Sbjct: 555 -LIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLG--PRRLDKLGLGADVA 611

Query: 386 KIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVLQAFGF 445
           ++  A+    + K   F+  + WRFD  +Q ++      +   FPGV      V Q    
Sbjct: 612 QVTGALR-SGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQYREK 670

Query: 446 FYF 448
            YF
Sbjct: 671 AYF 673


>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
           sapiens]
          Length = 569

 Score =  147 bits (372), Expect = 2e-35
 Identities = 139/487 (28%), Positives = 203/487 (41%), Gaps = 101/487 (20%)

Query: 59  IVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDV-----GHFSSFPGMPK------ 107
           + + ++  Q+   L  +G+LD  TL  M +PRCGVPD+         S PG P       
Sbjct: 85  LAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRR 144

Query: 108 ------------WR--------------KTHLTYRIVNYTPDLPRDAVDSA--IEKALKV 139
                       W+              K  L++R++           D    +  A ++
Sbjct: 145 SPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRM 204

Query: 140 WEEVTPLTFSR--LYEGEA-DIMISFAVKEH-GDFYSFDGPGHSLAHAYPPGPGLYGDIH 195
           W EVTPL F       G A DI + F    H G   +FDG G   AHA+       GDIH
Sbjct: 205 WSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWR-----LGDIH 259

Query: 196 FDDDEKWTEDASGTNLFL--VAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQD 253
           FDDDE +T   S T + L  VA HE+GH LGL H+  T ++M P Y    +   F L   
Sbjct: 260 FDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNY--IPQEPAFELDWS 317

Query: 254 DVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEY-------- 305
           D   IQ LYG    S +                       +FD I   R +Y        
Sbjct: 318 DRKAIQKLYGSCEGSFDT----------------------AFDWIRKERNQYGEVMVRFS 355

Query: 306 -LFFKDRYFWRRSHWNPEPEFH---LISAFWPSLPSY-LDAAYEVNS--RDTVFIFKGNE 358
             FF++ ++W   + N    +     I   WP +P++ +DA   + +  RD  + F+GN+
Sbjct: 356 TYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQ 415

Query: 359 FWAIRGNEVQA--------GYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRF 410
           +W    ++ QA         YP+ I   GFP     +D A  D+ +K  YFF     + F
Sbjct: 416 YWRYDSDKDQALTEDEQGKSYPKLISE-GFPGIPSPLDTAFYDRRQKLIYFFKESLVFAF 474

Query: 411 DENSQSMEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNA--RMVTHIL 468
           D N   +   +P+ I + FP V P+          +Y ++ +S F F  NA  ++V    
Sbjct: 475 DVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKD 534

Query: 469 K-SNSWL 474
           K  NSWL
Sbjct: 535 KQQNSWL 541


>gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 358

 Score =  102 bits (254), Expect = 8e-22
 Identities = 63/202 (31%), Positives = 102/202 (50%), Gaps = 52/202 (25%)

Query: 24  AKEEDSNKDLAQQYLEK-YYNLEKDVKQF-RRKDSNLIVKKIQGMQKFLGLEVTGKLDTD 81
           A+++   +    +YLE  YYNL+ ++ Q  R++DS+ +++K++ MQ F GL+        
Sbjct: 134 AQQQFPQESFPVKYLENCYYNLKSEINQIGRQRDSSPVLEKLKQMQNFFGLKDQ------ 187

Query: 82  TLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWE 141
                                                NY P+LP++ VD A  KA ++W 
Sbjct: 188 -------------------------------------NYMPNLPQEDVDRATGKAFELWS 210

Query: 142 EVTPLTFSRLYEGEADIMISFA----VKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFD 197
             + LTF+R +E E DI++SF     + ++  FY  DG    LAHA+PPGPG+ GD+HFD
Sbjct: 211 NASALTFTRDFESEGDIILSFVFLADLHDNSPFYGHDG---CLAHAFPPGPGIGGDVHFD 267

Query: 198 DDEKWTEDASGTNLFLVAAHEL 219
           +DE  T+D   +  ++V   +L
Sbjct: 268 NDETRTKDFRSSKHWVVQEDQL 289



 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 35/83 (42%), Positives = 62/83 (74%), Gaps = 2/83 (2%)

Query: 354 FKGNEFWAIRGNEVQAGYPRGIHT-LGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDE 412
           F+ ++ W ++ +++ +GYPR +++   FP  ++KIDAA+ +K+  KT+FF A++YWR+DE
Sbjct: 276 FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDE 335

Query: 413 NSQSMEQGFPRLIADDFPGVEPK 435
           N QS++ G+P++I DD PG+  K
Sbjct: 336 NMQSVDAGYPKII-DDLPGISKK 357


>gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 198

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 48/120 (40%), Positives = 74/120 (61%), Gaps = 13/120 (10%)

Query: 104 GMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFA 163
           G+ KW++        NY P+LP++ VD A  KA ++W + + LTF+R +E E DI++SF 
Sbjct: 19  GIQKWQEDQ------NYMPNLPQEDVDRATGKAFELWSKASALTFTRDFESEGDIILSFV 72

Query: 164 ----VKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHEL 219
               + ++  FY  DG    LAHA+PPGPG+ GD+HFD+DE  T+D   +  ++V   +L
Sbjct: 73  FLADLHDNSPFYGHDG---CLAHAFPPGPGIGGDVHFDNDETRTKDFRSSKHWVVQEDQL 129



 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 35/83 (42%), Positives = 62/83 (74%), Gaps = 2/83 (2%)

Query: 354 FKGNEFWAIRGNEVQAGYPRGIHT-LGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDE 412
           F+ ++ W ++ +++ +GYPR +++   FP  ++KIDAA+ +K+  KT+FF A++YWR+DE
Sbjct: 116 FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDE 175

Query: 413 NSQSMEQGFPRLIADDFPGVEPK 435
           N QS++ G+P++I DD PG+  K
Sbjct: 176 NMQSVDAGYPKII-DDLPGISKK 197


>gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 198

 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 48/120 (40%), Positives = 73/120 (60%), Gaps = 13/120 (10%)

Query: 104 GMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFA 163
           G+ KW++        NY P+LP++ VD A  KA ++W   + LTF+R +E E DI++SF 
Sbjct: 19  GIQKWQEDQ------NYMPNLPQEDVDRATGKAFELWSNASALTFTRDFESEGDIILSFV 72

Query: 164 ----VKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHEL 219
               + ++  FY  DG    LAHA+PPGPG+ GD+HFD+DE  T+D   +  ++V   +L
Sbjct: 73  FLADLHDNSPFYGHDG---CLAHAFPPGPGIGGDVHFDNDETRTKDFRSSKHWVVQEDQL 129



 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 35/83 (42%), Positives = 62/83 (74%), Gaps = 2/83 (2%)

Query: 354 FKGNEFWAIRGNEVQAGYPRGIHT-LGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDE 412
           F+ ++ W ++ +++ +GYPR +++   FP  ++KIDAA+ +K+  KT+FF A++YWR+DE
Sbjct: 116 FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDE 175

Query: 413 NSQSMEQGFPRLIADDFPGVEPK 435
           N QS++ G+P++I DD PG+  K
Sbjct: 176 NMQSVDAGYPKII-DDLPGISKK 197


>gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]
          Length = 390

 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 68/195 (34%), Positives = 99/195 (50%), Gaps = 25/195 (12%)

Query: 87  RKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDL--PRDAVDSAIEKALKVWEEVT 144
           R P    P    ++  P   +W   +LTYRI+++  +L  PR+    A+  A ++W +V+
Sbjct: 67  RVPGPLAPRRRRYTLTPARLRWDHFNLTYRILSFPRNLLSPRET-RRALAAAFRMWSDVS 125

Query: 145 PLTFSRLY-EGEADIMISFAVKEHGD------FYSFDGPGHSLAHAYPPGPGLYGDIHFD 197
           P +F  +  E  +D+ I F    H D       + FDGP   LAHA+ P    +G IHFD
Sbjct: 126 PFSFREVAPEQPSDLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFPP---HGGIHFD 182

Query: 198 DDEKWTEDASG---------TNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQF 248
           D E W    +          T+L  VAAHE+GH+LGL HS +  ALM   + + T     
Sbjct: 183 DSEYWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALM---HLNATLRGWK 239

Query: 249 RLSQDDVNGIQSLYG 263
            LSQD++ G+  LYG
Sbjct: 240 ALSQDELWGLHRLYG 254


>gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo
           sapiens]
          Length = 183

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 50/144 (34%), Positives = 77/144 (53%), Gaps = 3/144 (2%)

Query: 37  YLEKYYNLEKDVKQFRRKDSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDV 96
           YL +Y  L+K ++         I + ++  Q+   L V+G+LD  T   MR+PRCG+ D 
Sbjct: 31  YLSQYGYLQKPLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGLEDP 90

Query: 97  GHFSSFPGM--PKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEG 154
            +  +   +   +WRK HLT+RI+N    LP     +A+ +A + W  V PLTF  +  G
Sbjct: 91  FNQKTLKYLLLGRWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPLTFQEVQAG 150

Query: 155 EADIMISFAVKEHG-DFYSFDGPG 177
            ADI +SF  ++      +FDGPG
Sbjct: 151 AADIRLSFHGRQSSYCSNTFDGPG 174


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.431 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,668,220
Number of Sequences: 37866
Number of extensions: 1014933
Number of successful extensions: 3197
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 2926
Number of HSP's gapped (non-prelim): 82
length of query: 476
length of database: 18,247,518
effective HSP length: 106
effective length of query: 370
effective length of database: 14,233,722
effective search space: 5266477140
effective search space used: 5266477140
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.