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Search of human proteins with 130484567
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|130484567 HFM1 protein [Homo sapiens]
(1435 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|130484567 HFM1 protein [Homo sapiens] 2850 0.0
gi|76880486 activating signal cointegrator 1 complex subunit 3 i... 330 5e-90
gi|40217847 activating signal cointegrator 1 complex subunit 3-l... 323 7e-88
gi|169218225 PREDICTED: similar to U5 snRNP-specific 200kD prote... 321 3e-87
gi|139394648 DNA polymerase theta [Homo sapiens] 135 3e-31
gi|110556640 DNA helicase HEL308 [Homo sapiens] 115 4e-25
gi|193211480 superkiller viralicidic activity 2-like 2 [Homo sap... 114 7e-25
gi|67782311 superkiller viralicidic activity 2-like homolog [Hom... 114 7e-25
gi|222831595 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 [Homo sap... 57 2e-07
gi|149274648 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like [Hom... 50 2e-05
gi|51094101 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 2 ... 45 7e-04
gi|164419743 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 1... 45 7e-04
gi|90819229 cutaneous T-cell lymphoma-associated antigen 1 isofo... 42 0.004
gi|116812616 RecQ protein-like 4 [Homo sapiens] 42 0.006
gi|31542656 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 [Homo sapi... 42 0.006
gi|38327634 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 [Homo sapi... 41 0.007
gi|13129006 nucleolar protein GU2 [Homo sapiens] 41 0.009
gi|110735439 Werner syndrome protein [Homo sapiens] 40 0.021
gi|169218196 PREDICTED: similar to Werner syndrome ATP-dependent... 40 0.021
gi|209862869 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 3 ... 40 0.021
gi|13518015 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 1 [... 40 0.021
gi|216548263 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 2 ... 40 0.021
gi|74959747 Fanconi anemia, complementation group M [Homo sapiens] 39 0.028
gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo sapi... 39 0.028
gi|41327776 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 isoform 2 ... 39 0.047
gi|20149629 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 isoform 1 ... 39 0.047
gi|27881482 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I [... 37 0.14
gi|188035877 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 [Homo sap... 37 0.18
gi|41327779 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 [Homo sapi... 37 0.18
gi|154350236 hypothetical protein LOC56204 [Homo sapiens] 36 0.23
>gi|130484567 HFM1 protein [Homo sapiens]
Length = 1435
Score = 2850 bits (7389), Expect = 0.0
Identities = 1435/1435 (100%), Positives = 1435/1435 (100%)
Query: 1 MLKSNDCLFSLENLFFEKPDEVENHPDNEKSLDWFLPPAPLISEIPDTQELEEELESHKL 60
MLKSNDCLFSLENLFFEKPDEVENHPDNEKSLDWFLPPAPLISEIPDTQELEEELESHKL
Sbjct: 1 MLKSNDCLFSLENLFFEKPDEVENHPDNEKSLDWFLPPAPLISEIPDTQELEEELESHKL 60
Query: 61 LGQEKRPKMLTSNLKITNEDTNYISLTQKFQFAFPSDKYEQDDLNLEGVGNNDLSHIAGK 120
LGQEKRPKMLTSNLKITNEDTNYISLTQKFQFAFPSDKYEQDDLNLEGVGNNDLSHIAGK
Sbjct: 61 LGQEKRPKMLTSNLKITNEDTNYISLTQKFQFAFPSDKYEQDDLNLEGVGNNDLSHIAGK 120
Query: 121 LTYASQKYKNHIGTEIAPEKSVPDDTKLVNFAEDKGESTSVFRKRLFKISDNIHGSAYSN 180
LTYASQKYKNHIGTEIAPEKSVPDDTKLVNFAEDKGESTSVFRKRLFKISDNIHGSAYSN
Sbjct: 121 LTYASQKYKNHIGTEIAPEKSVPDDTKLVNFAEDKGESTSVFRKRLFKISDNIHGSAYSN 180
Query: 181 DNELDSHIGSVKIVQTEMNKGKSRNYSNSKQKFQYSANVFTANNAFSASEIGEGMFKAPS 240
DNELDSHIGSVKIVQTEMNKGKSRNYSNSKQKFQYSANVFTANNAFSASEIGEGMFKAPS
Sbjct: 181 DNELDSHIGSVKIVQTEMNKGKSRNYSNSKQKFQYSANVFTANNAFSASEIGEGMFKAPS 240
Query: 241 FSVAFQPHDIQEVTENGLGSLKAVTEIPAKFRSIFKEFPYFNYIQSKAFDDLLYTDRNFV 300
FSVAFQPHDIQEVTENGLGSLKAVTEIPAKFRSIFKEFPYFNYIQSKAFDDLLYTDRNFV
Sbjct: 241 FSVAFQPHDIQEVTENGLGSLKAVTEIPAKFRSIFKEFPYFNYIQSKAFDDLLYTDRNFV 300
Query: 301 ICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGPIGLN 360
ICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGPIGLN
Sbjct: 301 ICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGPIGLN 360
Query: 361 CKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVQLVRLFLIDEVHIVKDEN 420
CKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVQLVRLFLIDEVHIVKDEN
Sbjct: 361 CKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVQLVRLFLIDEVHIVKDEN 420
Query: 421 RGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVAVSATIPNAEDIAEWLSDGERPAVCL 480
RGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVAVSATIPNAEDIAEWLSDGERPAVCL
Sbjct: 421 RGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVAVSATIPNAEDIAEWLSDGERPAVCL 480
Query: 481 KMDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNYKIASVIQMYSDQKPTLVFCATRKGV 540
KMDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNYKIASVIQMYSDQKPTLVFCATRKGV
Sbjct: 481 KMDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNYKIASVIQMYSDQKPTLVFCATRKGV 540
Query: 541 QQAASVLVKDAKFIMTVEQKQRLQKYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEG 600
QQAASVLVKDAKFIMTVEQKQRLQKYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEG
Sbjct: 541 QQAASVLVKDAKFIMTVEQKQRLQKYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEG 600
Query: 601 AFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEEYSETDILQMIGRAGRPQF 660
AFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEEYSETDILQMIGRAGRPQF
Sbjct: 601 AFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEEYSETDILQMIGRAGRPQF 660
Query: 661 DTTATAVIMTRLSTRDKYIQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAVEWIR 720
DTTATAVIMTRLSTRDKYIQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAVEWIR
Sbjct: 661 DTTATAVIMTRLSTRDKYIQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAVEWIR 720
Query: 721 STLLYIRALKNPSHYGFASGLNKDGIEAKLQELCLKNLNDLSSLDLIKMDEGVNFKPTEA 780
STLLYIRALKNPSHYGFASGLNKDGIEAKLQELCLKNLNDLSSLDLIKMDEGVNFKPTEA
Sbjct: 721 STLLYIRALKNPSHYGFASGLNKDGIEAKLQELCLKNLNDLSSLDLIKMDEGVNFKPTEA 780
Query: 781 GRLMAWYYITFETVKKFYTISGKETLSDLVTLIAGCKEFLDIQLRINEKKTLNTLNKDPN 840
GRLMAWYYITFETVKKFYTISGKETLSDLVTLIAGCKEFLDIQLRINEKKTLNTLNKDPN
Sbjct: 781 GRLMAWYYITFETVKKFYTISGKETLSDLVTLIAGCKEFLDIQLRINEKKTLNTLNKDPN 840
Query: 841 RITIRFPMEGRIKTREMKVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDFVA 900
RITIRFPMEGRIKTREMKVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDFVA
Sbjct: 841 RITIRFPMEGRIKTREMKVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDFVA 900
Query: 901 AQEKKFAVLLNSLILAKCFRCKLWENSLHVSKQLEKIGITLSNAIVNAGLTSFKKIEETD 960
AQEKKFAVLLNSLILAKCFRCKLWENSLHVSKQLEKIGITLSNAIVNAGLTSFKKIEETD
Sbjct: 901 AQEKKFAVLLNSLILAKCFRCKLWENSLHVSKQLEKIGITLSNAIVNAGLTSFKKIEETD 960
Query: 961 ARELELILNRHPPFGTQIKETVMYLPKYELKVEQITRYSDTTAEILVTVILRNFEQLQTK 1020
ARELELILNRHPPFGTQIKETVMYLPKYELKVEQITRYSDTTAEILVTVILRNFEQLQTK
Sbjct: 961 ARELELILNRHPPFGTQIKETVMYLPKYELKVEQITRYSDTTAEILVTVILRNFEQLQTK 1020
Query: 1021 RTASDSHYVTLIIGDADNQVVYLHKITDSVLLKAGSWAKKIAVKRALKSEDLSINLISSE 1080
RTASDSHYVTLIIGDADNQVVYLHKITDSVLLKAGSWAKKIAVKRALKSEDLSINLISSE
Sbjct: 1021 RTASDSHYVTLIIGDADNQVVYLHKITDSVLLKAGSWAKKIAVKRALKSEDLSINLISSE 1080
Query: 1081 FVGLDIQQKLTVFYLEPKRFGNQITMQRKSETQISHSKHSDISTIAGPNKGTTASKKPGN 1140
FVGLDIQQKLTVFYLEPKRFGNQITMQRKSETQISHSKHSDISTIAGPNKGTTASKKPGN
Sbjct: 1081 FVGLDIQQKLTVFYLEPKRFGNQITMQRKSETQISHSKHSDISTIAGPNKGTTASKKPGN 1140
Query: 1141 RECNHLCKSKHTCGHDCCKIGVAQKSEIKESTISSYLSDLRNRNAVSSVPPVKRLKIQMN 1200
RECNHLCKSKHTCGHDCCKIGVAQKSEIKESTISSYLSDLRNRNAVSSVPPVKRLKIQMN
Sbjct: 1141 RECNHLCKSKHTCGHDCCKIGVAQKSEIKESTISSYLSDLRNRNAVSSVPPVKRLKIQMN 1200
Query: 1201 KSQSVDLKEFGFTPKPSLPSISRSEYLNISELPIMEQWDQPEIYGKVRQEPSEYQDKEVL 1260
KSQSVDLKEFGFTPKPSLPSISRSEYLNISELPIMEQWDQPEIYGKVRQEPSEYQDKEVL
Sbjct: 1201 KSQSVDLKEFGFTPKPSLPSISRSEYLNISELPIMEQWDQPEIYGKVRQEPSEYQDKEVL 1260
Query: 1261 NVNFELGNEVWDDFDDENLEVTSFSTDTEKTKISGFGNTLSSSTRGSKLPLQESKSKFQR 1320
NVNFELGNEVWDDFDDENLEVTSFSTDTEKTKISGFGNTLSSSTRGSKLPLQESKSKFQR
Sbjct: 1261 NVNFELGNEVWDDFDDENLEVTSFSTDTEKTKISGFGNTLSSSTRGSKLPLQESKSKFQR 1320
Query: 1321 EMSNSFVSSHEMSDISLSNSAMPKFSASSMTKLPQQAGNAVIVHFQERKPQNLSPEIEKQ 1380
EMSNSFVSSHEMSDISLSNSAMPKFSASSMTKLPQQAGNAVIVHFQERKPQNLSPEIEKQ
Sbjct: 1321 EMSNSFVSSHEMSDISLSNSAMPKFSASSMTKLPQQAGNAVIVHFQERKPQNLSPEIEKQ 1380
Query: 1381 CFTFSEKNPNSSNYKKVDFFIRNSECKKEVDFSMYHPDDEADEMKSLLGIFDGIF 1435
CFTFSEKNPNSSNYKKVDFFIRNSECKKEVDFSMYHPDDEADEMKSLLGIFDGIF
Sbjct: 1381 CFTFSEKNPNSSNYKKVDFFIRNSECKKEVDFSMYHPDDEADEMKSLLGIFDGIF 1435
>gi|76880486 activating signal cointegrator 1 complex subunit 3
isoform a [Homo sapiens]
Length = 2202
Score = 330 bits (847), Expect = 5e-90
Identities = 231/664 (34%), Positives = 355/664 (53%), Gaps = 47/664 (7%)
Query: 264 VTEIPAKFRSIFKEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLME 323
+T + K F +FN +Q++ F L +TD N ++ APTGSGKTV ELAI R+ +
Sbjct: 1310 ITALGCKAYEALYNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNK 1369
Query: 324 VPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGP-IGLNCKELTGDTVMDDLFEIQHAHII 382
P K VY+AP+KAL +R DDWK + +G ELTGD V D+ I A +I
Sbjct: 1370 YPTS----KAVYIAPLKALVRERMDDWKVRIEEKLGKKVIELTGD-VTPDMKSIAKADLI 1424
Query: 383 MTTPEKWDSMTRKWRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTL 442
+TTPEKWD ++R W++ + VQ V + +IDE+H++ +E RGP LEV+VSR + S
Sbjct: 1425 VTTPEKWDGVSRSWQNRNYVQQVTILIIDEIHLLGEE-RGPVLEVIVSRTNFISS----- 1478
Query: 443 KNTSTAIPMRFVAVSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSS 502
T P+R V +S + NA D+A+WL+ + + S RPV L+ + GFP
Sbjct: 1479 ---HTEKPVRIVGLSTALANARDLADWLNIKQMGLFNFR--PSVRPVPLEVHIQGFP--- 1530
Query: 503 NQTEFKFDLTLNYKIASVIQMYSDQKPTLVFCATRKGVQQAASVLV------KDAKFIMT 556
Q ++N I+ +S KP L+F ++R+ + A L+ +D K +
Sbjct: 1531 GQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTALELIAFLATEEDPKQWLN 1590
Query: 557 VEQKQRLQKYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTL 616
+++++ ++ +VRDS L+ L G HHAG+ DRK VE F + VL TSTL
Sbjct: 1591 MDERE-MENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTL 1649
Query: 617 AMGVNLPAHLVVIKSTMHYAGGL--FEEYSETDILQMIGRAGRPQFDTTATAVIMTRLST 674
A GVN PAHLV+IK T +Y G + ++ TD+LQM+GRAGRPQFD AVI+
Sbjct: 1650 AWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIK 1709
Query: 675 RDKYIQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAVEWIRSTLLYIRALKNPSH 734
+D Y + L VESSL L +HLNAEI TIT A+++I T + R + NPS+
Sbjct: 1710 KDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALDYITWTYFFRRLIMNPSY 1769
Query: 735 YGFASGLNKDGIEAKLQELCLKNLNDLSSLDLIKM-DEGVNFKPTEAGRLMAWYYITFET 793
Y ++ D + L L K+L +L I++ ++ + +P GR+ ++YY+ +T
Sbjct: 1770 YNLGD-VSHDSVNKFLSHLIEKSLIELELSYCIEIGEDNRSIEPLTYGRIASYYYLKHQT 1828
Query: 794 VKKFY-TISGKETLSDLVTLIAGCKEFLDIQLRINEKKTLNTLNKDPNRITIRFPMEGR- 851
VK F + + + +L+++++ +E+ D+ +R NE + L K P+E
Sbjct: 1829 VKMFKDRLKPECSTEELLSILSDAEEYTDLPVRHNEDHMNSELAK-------CLPIESNP 1881
Query: 852 --IKTREMKVNCLIQAQL--GCIPIQDFALTQDTAKIFRHGSRITRWLSDFVAAQEKKFA 907
+ K + L+QA L +P D+ DT + R+ + + D VAA +
Sbjct: 1882 HSFDSPHTKAHLLLQAHLSRAMLPCPDY--DTDTKTVLDQALRVCQAMLD-VAANQGWLV 1938
Query: 908 VLLN 911
+LN
Sbjct: 1939 TVLN 1942
Score = 318 bits (816), Expect = 2e-86
Identities = 243/756 (32%), Positives = 387/756 (51%), Gaps = 66/756 (8%)
Query: 275 FKEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLL----MEVPLPWLN 330
FK N IQS F+ T+ N +ICAPTG+GKT + L + + + +
Sbjct: 471 FKGMKRLNRIQSIVFETAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNE 530
Query: 331 IKIVYMAPIKALCSQRFDDWKEKFGPIGLNCKELTGDTVMDDLFEIQHAHIIMTTPEKWD 390
KIVY+AP+KAL ++ D + + P+G+ KELTGD + EI +++TTPEKWD
Sbjct: 531 FKIVYVAPMKALAAEMTDYFSRRLEPLGIIVKELTGDMQLSKS-EILRTQMLVTTPEKWD 589
Query: 391 SMTRKW-RDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAI 449
+TRK D +L Q+VRL ++DEVH++ E+RGP LE +V+R T++ V ST
Sbjct: 590 VVTRKSVGDVALSQIVRLLILDEVHLLH-EDRGPVLESIVAR--TLRQVE------STQS 640
Query: 450 PMRFVAVSATIPNAEDIAEWLSDGERPAVCLKM-DESHRPVKLQKVVLGFPCSSNQTEFK 508
+R + +SAT+PN D+A +L P + L D RPV L + LG C++ +
Sbjct: 641 MIRILGLSATLPNYLDVATFLH--VNPYIGLFFFDGRFRPVPLGQTFLGIKCANKMQQLN 698
Query: 509 FDLTLNYKIASVIQMYSDQKPTLVFCATRKGVQQAASVLVKDAK-------FIMTVEQKQ 561
+ Y+ +V++ +VF R + A L++ AK F T
Sbjct: 699 NMDEVCYE--NVLKQVKAGHQVMVFVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDY 756
Query: 562 RL-QKYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGV 620
L +K R+ ++R++ DG + HHAGM DR +VE F+ G + VL T+TLA GV
Sbjct: 757 VLAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGV 816
Query: 621 NLPAHLVVIKSTMHYAG--GLFEEYSETDILQMIGRAGRPQFDTTATAVIMTRLSTRDKY 678
NLPAH V+IK T YA G F + D++Q+ GRAGRPQFD +I+T Y
Sbjct: 817 NLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHY 876
Query: 679 IQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAVEWIRSTLLYIRALKNPSHYGFA 738
+ +L R+ +ES L ++LNAEI L T+T+V AV+WI T LY+R NP YG +
Sbjct: 877 LTLLTQRNPIESQFLESLADNLNAEIALGTVTNVEEAVKWISYTYLYVRMRANPLAYGIS 936
Query: 739 SGLNK--DGIEAKLQELCLKNLNDLSSLDLIKMDEGVN-FKPTEAGRLMAWYYITFETVK 795
+ + ++L ++ L +I+ +E F T+ GR + YYI + T++
Sbjct: 937 HKAYQIDPTLRKHREQLVIEVGRKLDKAQMIRFEERTGYFSSTDLGRTASHYYIKYNTIE 996
Query: 796 KFYTI-SGKETLSDLVTLIAGCKEFLDIQLRINEKKTLNTLNKDPNRITIRFPMEGRIKT 854
F + +T D+ +++ +EF I++R E + L+TL N + P G ++
Sbjct: 997 TFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEELDTLLS--NFCELSTP--GGVEN 1052
Query: 855 REMKVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDFVAAQEKKFAVLLNSLI 914
K+N L+Q + + F+L D+A + ++ +RI R L F A K++ + L+
Sbjct: 1053 SYGKINILLQTYISRGEMDSFSLISDSAYVAQNAARIVRAL--FEIALRKRWPTMTYRLL 1110
Query: 915 -LAKCFRCKLW-------ENSL---HVSKQLEKIGITLSNAIVNAGLTSFKKIEETDARE 963
L+K +LW + S+ H+ +LE+ +T+ K+++ E
Sbjct: 1111 NLSKVIDKRLWGWASPLRQFSILPPHILTRLEEKKLTVD------------KLKDMRKDE 1158
Query: 964 LELILNRHPPFGTQIKETVMYLPK--YELKVEQITR 997
+ IL+ H G ++K+ V +P E ++ ITR
Sbjct: 1159 IGHILH-HVNIGLKVKQCVHQIPSVMMEASIQPITR 1193
>gi|40217847 activating signal cointegrator 1 complex subunit 3-like 1
[Homo sapiens]
Length = 2136
Score = 323 bits (828), Expect = 7e-88
Identities = 267/866 (30%), Positives = 444/866 (51%), Gaps = 67/866 (7%)
Query: 219 VFTANNAFSAS---EIGEGMFKAPSFSVAFQPHDIQEVTENGLGS---LKAVTEIPAKFR 272
VFT + F A+ ++ +G F+ ++ + + GS L V ++P +
Sbjct: 415 VFTQGSHFMANKRCQLPDGSFRRQR--KGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQ 472
Query: 273 SIFKEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLL-----MEVPLP 327
+ F+ F N IQSK + L TD N ++CAPTG+GKT V + + R + M+ +
Sbjct: 473 AGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTIN 532
Query: 328 WLNIKIVYMAPIKALCSQRFDDWKEKFGPIGLNCKELTGDTVMDDLFEIQHAHIIMTTPE 387
+ KI+Y+AP+++L + + ++ G+ ELTGD + EI II+ TPE
Sbjct: 533 VDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKE-EISATQIIVCTPE 591
Query: 388 KWDSMTRKWRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTST 447
KWD +TRK + + QLVRL ++DE+H++ D+ RGP LE +V+R ++++ T ++
Sbjct: 592 KWDIITRKGGERTYTQLVRLIILDEIHLLHDD-RGPVLEALVAR--AIRNIEMTQED--- 645
Query: 448 AIPMRFVAVSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSSNQTEF 507
+R + +SAT+PN ED+A +L + D S RPV L++ +G F
Sbjct: 646 ---VRLIGLSATLPNYEDVATFLRVDPAKGL-FYFDNSFRPVPLEQTYVGITEKKAIKRF 701
Query: 508 KFDLTLNYKIASVIQMYSDQKPTLVFCATRKGVQQAASV-----LVKDAKFIMTVE---Q 559
+ +N + I ++ + LVF +RK + A L KD + E
Sbjct: 702 QI---MNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSAS 758
Query: 560 KQRLQKYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMG 619
+ L+ A ++ +L+D+L G A HHAGM DR +VE F + VL +T+TLA G
Sbjct: 759 TEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWG 818
Query: 620 VNLPAHLVVIKSTMHYAG--GLFEEYSETDILQMIGRAGRPQFDTTATAVIMTRLSTRDK 677
VNLPAH V+IK T Y+ G + E DILQM+GRAGRPQ+DT +++T
Sbjct: 819 VNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQY 878
Query: 678 YIQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAVEWIRSTLLYIRALKNPSHYGF 737
Y+ +L + +ES + L + LNAEIVL + + AV W+ LYIR L++P+ YG
Sbjct: 879 YLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGI 938
Query: 738 ASGLNKDG--IEAKLQELCLKNLNDLSSLDLIKMDEGV-NFKPTEAGRLMAWYYITFETV 794
+ K ++ + +L L +L+K D+ NF+ TE GR+ + YYIT +TV
Sbjct: 939 SHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTV 998
Query: 795 KKFYTISGKETLS--DLVTLIAGCKEFLDIQLRINEKKTLNTLNKDPNRITIRFPMEGRI 852
+ + + K TLS +L + + EF +I +R EK L L + + P++ I
Sbjct: 999 QTYNQLL-KPTLSEIELFRVFSLSSEFKNITVREEEKLELQKLLE-----RVPIPVKESI 1052
Query: 853 KTREMKVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDFVAAQEKKFAVLLN- 911
+ K+N L+QA + + ++ FAL D + + R+ R + + V + +A L +
Sbjct: 1053 EEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIFEIVL--NRGWAQLTDK 1110
Query: 912 SLILAKCFRCKLWENSLHVSKQLEKIGITLSNAIVNAGLTSFKKIEETDAREL-ELILNR 970
+L L K ++W+ S+ +Q K+ + I F+++ + + E+ ELI R
Sbjct: 1111 TLNLCKMIDKRMWQ-SMCPLRQFRKLPEEVVKKIEKKNF-PFERLYDLNHNEIGELI--R 1166
Query: 971 HPPFGTQIKETVMYLPKYELKV--EQITRYSDTTAEILVTVILRNFEQLQTKRTASDSHY 1028
P G I + V PK EL V + ITR +T ++ +T I +F+ + +S++ +
Sbjct: 1167 MPKMGKTIHKYVHLFPKLELSVHLQPITR---STLKVELT-ITPDFQWDEKVHGSSEAFW 1222
Query: 1029 VTLIIGDADNQVVYLHKITDSVLLKA 1054
+ ++ D D++V+ H + LLKA
Sbjct: 1223 I--LVEDVDSEVILHH---EYFLLKA 1243
Score = 318 bits (816), Expect = 2e-86
Identities = 247/845 (29%), Positives = 421/845 (49%), Gaps = 60/845 (7%)
Query: 271 FRSIFKE-FPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWL 329
F S++++ FP+FN IQ++ F+ + +D N + APTGSGKT+ E AI R+L++
Sbjct: 1317 FESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQSS---- 1372
Query: 330 NIKIVYMAPIKALCSQRFDDWKEKFGPIGLNCKE--LTGDTVMDDLFEIQHAHIIMTTPE 387
+ VY+ P++AL Q + DW EKF LN K LTG+T DL + +II++TPE
Sbjct: 1373 EGRCVYITPMEALAEQVYMDWYEKFQD-RLNKKVVLLTGET-STDLKLLGKGNIIISTPE 1430
Query: 388 KWDSMTRKWRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTST 447
KWD ++R+W+ VQ + LF++DEVH++ EN GP LEV+ SRM+ + S +
Sbjct: 1431 KWDILSRRWKQRKNVQNINLFVVDEVHLIGGEN-GPVLEVICSRMRYISSQIER------ 1483
Query: 448 AIPMRFVAVSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSSNQTEF 507
P+R VA+S+++ NA+D+A WL G + RPV L+ + GF S QT
Sbjct: 1484 --PIRIVALSSSLSNAKDVAHWL--GCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRL 1539
Query: 508 KFDLTLNYKIASVIQMYSDQKPTLVFCATRKGVQQAASVL-------VKDAKFIMTVEQK 560
L++ + I +S +KP +VF +RK + A + ++ +F+ E+
Sbjct: 1540 ---LSMAKPVYHAITKHSPKKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKD 1596
Query: 561 QRLQKYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGV 620
L Y + DS L++ L +G Y H G+ +R++VE F+ G + V+ + +L G+
Sbjct: 1597 --LIPYLEKLSDSTLKETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGM 1654
Query: 621 NLPAHLVVIKSTMHYAGGL--FEEYSETDILQMIGRAGRPQFDTTATAVIMTRLSTRDKY 678
N+ AHLV+I T +Y G + + +Y D+LQM+G A RP D VIM + S +D +
Sbjct: 1655 NVAAHLVIIMDTQYYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFF 1714
Query: 679 IQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAVEWIRSTLLYIRALKNPSHYGFA 738
+ L VES L + +H NAEIV TI + AV+++ T LY R +NP++Y
Sbjct: 1715 KKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNL- 1773
Query: 739 SGLNKDGIEAKLQELCLKNLNDLSSLDLIKMDEGVNFKPTEAGRLMAWYYITFETVKKF- 797
G++ + L EL + L+DL I +++ ++ P G + A+YYI + T++ F
Sbjct: 1774 QGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEMDVAPLNLGMIAAYYYINYTTIELFS 1833
Query: 798 YTISGKETLSDLVTLIAGCKEFLDIQLRINEKKTLNTL-NKDPNRITIRFPMEGRIKTRE 856
+++ K + L+ +I+ E+ +I +R +E L L K P+++ +
Sbjct: 1834 MSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVPHKLN-----NPKFNDPH 1888
Query: 857 MKVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDFVAAQEKKFAVLLNSLILA 916
+K N L+QA L + + L DT +I R+ + D V + + L ++ LA
Sbjct: 1889 VKTNLLLQAHLSRMQL-SAELQSDTEEILSKAIRLIQACVD-VLSSNGWLSPALAAMELA 1946
Query: 917 KCFRCKLWENSLHVSKQLEKIGITLSNAIVNAGLTSFKKIEETDARELELILNRHPPFGT 976
+ +W ++ KQL + G+ S I E + E +L
Sbjct: 1947 QMVTQAMWSKDSYL-KQLPHFTSEHIKRCTDKGVESVFDIMEMEDEERNALLQLTDSQIA 2005
Query: 977 QIKETVMYLPKYELKVEQITRYSDTTAEILVTVILRNFEQLQT--------KRTASDSHY 1028
+ P EL E + + S + +V ++ E+ T + + +
Sbjct: 2006 DVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEGWW 2065
Query: 1029 VTLIIGDA-DNQVVYLHKITDSVLLKAGSWAKKIAVKRALKSEDLSINLISSEFVGLDIQ 1087
V +IGDA N ++ + ++T L+ + K V A + + ++ +S ++G D +
Sbjct: 2066 V--VIGDAKSNSLISIKRLT----LQQKAKVKLDFVAPATGAHNYTLYFMSDAYMGCDQE 2119
Query: 1088 QKLTV 1092
K +V
Sbjct: 2120 YKFSV 2124
>gi|169218225 PREDICTED: similar to U5 snRNP-specific 200kD protein,
partial [Homo sapiens]
Length = 1700
Score = 321 bits (823), Expect = 3e-87
Identities = 258/818 (31%), Positives = 425/818 (51%), Gaps = 59/818 (7%)
Query: 261 LKAVTEIPAKFRSIFKEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRL 320
L V ++P ++ F+ F N IQSK + L TD N ++CAPTG+GKT V + + R
Sbjct: 25 LLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLRE 84
Query: 321 L-----MEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGPIGLNCKELTGDTVMDDLFE 375
+ M+ + + KI+Y+AP+++L + + ++ G+ ELTGD + E
Sbjct: 85 IGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKE-E 143
Query: 376 IQHAHIIMTTPEKWDSMTRKWRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTV 435
I II+ TPEKWD +TRK + + QLVRL ++DE+H++ D+ RGP LE +V+R +
Sbjct: 144 ISATQIIVCTPEKWDIITRKGGERTYTQLVRLIVLDEIHLLHDD-RGPVLEALVAR--AI 200
Query: 436 QSVSQTLKNTSTAIPMRFVAVSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQKVV 495
+++ T ++ +R + +SAT+PN ED+A +L + D S RPV L++
Sbjct: 201 RNIEMTQED------VRLIGLSATLPNYEDVATFLRVDPAKGL-FYFDNSFRPVPLEQTY 253
Query: 496 LGFPCSSNQTEFKFDLTLNYKIASVIQMYSDQKPTLVFCATRKGVQQAASV-----LVKD 550
+G F+ +N + I ++ + LVF +RK + A L KD
Sbjct: 254 VGITEKKAIKRFQI---MNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKD 310
Query: 551 AKFIMTVE---QKQRLQKYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDL 607
+ E + L+ A ++ +L+D+L G A HHAGM DR +VE F +
Sbjct: 311 TLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFGDKHI 370
Query: 608 PVLFTTSTLAMGVNLPAHLVVIKSTMHYAG--GLFEEYSETDILQMIGRAGRPQFDTTAT 665
VL +T+TLA GVNLPAH V+IK T Y+ G + E DILQM+GRAGRPQ+DT
Sbjct: 371 QVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGE 430
Query: 666 AVIMTRLSTRDKYIQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAVEWIRSTLLY 725
+++T Y+ +L + +ES + L + LNAEIVL + + AV W+ LY
Sbjct: 431 GILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDAVNWLGYAYLY 490
Query: 726 IRALKNPSHYGFASGLNKDG--IEAKLQELCLKNLNDLSSLDLIKMDEGV-NFKPTEAGR 782
IR L++P+ YG + K ++ + +L L +L+K D+ NF+ TE GR
Sbjct: 491 IRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKTGNFQVTELGR 550
Query: 783 LMAWYYITFETVKKFYTISGKETLS--DLVTLIAGCKEFLDIQLRINEKKTLNTLNKDPN 840
+ + YYIT +TV+ + + K TLS +L + + EF +I +R EK L L +
Sbjct: 551 IASHYYITNDTVQTYNQLL-KPTLSEIELFRVFSLSSEFKNITVREEEKLELQKLLE--- 606
Query: 841 RITIRFPMEGRIKTREMKVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDFVA 900
+ P++ I+ K+N L+QA + + ++ FAL D + + R+ R + + V
Sbjct: 607 --RVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSAGRLMRAIFEIVL 664
Query: 901 AQEKKFAVLLN-SLILAKCFRCKLWENSLHVSKQLEKIGITLSNAIVNAGLTSFKKIEET 959
+ +A L + +L L K ++W+ S+ +Q K+ + I F+++ +
Sbjct: 665 --NRGWAQLTDKTLNLCKMIDKRMWQ-SMCPLRQFRKLPEEVVKKIEKKNF-PFERLYDL 720
Query: 960 DAREL-ELILNRHPPFGTQIKETVMYLPKYELKV--EQITRYSDTTAEILVTVILRNFEQ 1016
+ E+ ELI R P G I + V PK EL V + ITR +T ++ +T I +F+
Sbjct: 721 NHNEIGELI--RMPKMGKTIHKYVHLFPKLELSVHLQPITR---STLKVELT-ITPDFQW 774
Query: 1017 LQTKRTASDSHYVTLIIGDADNQVVYLHKITDSVLLKA 1054
+ +S++ ++ ++ D D++V+ H + LLKA
Sbjct: 775 DEKVHGSSEAFWI--LVEDVDSEVILHH---EYFLLKA 807
Score = 311 bits (798), Expect = 2e-84
Identities = 244/845 (28%), Positives = 419/845 (49%), Gaps = 60/845 (7%)
Query: 271 FRSIFKE-FPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWL 329
F S++++ FP+FN IQ++ F+ + +D N + APTGSGKT+ E AI R+L++
Sbjct: 881 FESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQNS---- 936
Query: 330 NIKIVYMAPIKALCSQRFDDWKEKFGPIGLNCKE--LTGDTVMDDLFEIQHAHIIMTTPE 387
+ VY+ P++ Q + DW EKF LN K LTG+T DL + +II++TPE
Sbjct: 937 EGRCVYITPMRLWQEQVYMDWYEKFQD-RLNKKVVLLTGET-STDLKLLGKGNIIISTPE 994
Query: 388 KWDSMTRKWRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTST 447
KWD ++R+W+ VQ + LF++DEVH++ EN GP LEV+ SRM+ + S +
Sbjct: 995 KWDILSRRWKQRKNVQNINLFVVDEVHLIGGEN-GPVLEVICSRMRYISSQIER------ 1047
Query: 448 AIPMRFVAVSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSSNQTEF 507
P+R VA+S+++ NA+D+A WL G + RPV L+ + GF S QT
Sbjct: 1048 --PIRIVALSSSLSNAKDVAHWL--GCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRL 1103
Query: 508 KFDLTLNYKIASVIQMYSDQKPTLVFCATRKGVQQAASVL-------VKDAKFIMTVEQK 560
L++ + I +S +KP +VF +RK + A + ++ +F+ E+
Sbjct: 1104 ---LSMAKPVFHAITKHSPKKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKD 1160
Query: 561 QRLQKYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGV 620
L Y + DS L++ L +G Y H G+ +R++VE F+ G + V+ + +L G+
Sbjct: 1161 --LIPYLEKLSDSTLKETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGM 1218
Query: 621 NLPAHLVVIKSTMHYAGGL--FEEYSETDILQMIGRAGRPQFDTTATAVIMTRLSTRDKY 678
N+ AHLV+I T++Y G + + +Y D+LQM+G A RP D VIM + S +D +
Sbjct: 1219 NVAAHLVIIMDTLYYNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFF 1278
Query: 679 IQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAVEWIRSTLLYIRALKNPSHYGFA 738
+ L VES L + +H NAEIV TI + AV+++ T LY R +NP++Y
Sbjct: 1279 KKFLYEPLPVESHLDHCMHDHFNAEIVTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNL- 1337
Query: 739 SGLNKDGIEAKLQELCLKNLNDLSSLDLIKMDEGVNFKPTEAGRLMAWYYITFETVKKF- 797
G++ + L EL + L+DL I +++ ++ P G + A+YYI + T++ F
Sbjct: 1338 QGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEMDVAPLNLGMIAAYYYINYTTIELFS 1397
Query: 798 YTISGKETLSDLVTLIAGCKEFLDIQLRINEKKTLNTL-NKDPNRITIRFPMEGRIKTRE 856
+++ K + L+ +I+ E+ +I +R +E L L K P+++ +
Sbjct: 1398 MSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVPHKLN-----NPKFNDPH 1452
Query: 857 MKVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDFVAAQEKKFAVLLNSLILA 916
+K N L+QA L + + L DT +I R+ + D V + + L ++ LA
Sbjct: 1453 VKTNLLLQAHLSRMQL-SAELQSDTEEILSKAIRLIQACVD-VLSSNGWLSPALAAMELA 1510
Query: 917 KCFRCKLWENSLHVSKQLEKIGITLSNAIVNAGLTSFKKIEETDARELELILNRHPPFGT 976
+ +W ++ ++L L + G+ S I E + E +L
Sbjct: 1511 QMVTQAMWSEDSYL-RRLPPFPSGLFKRCTDKGVESVFDIMEMEDEERNALLQLTDSQIA 1569
Query: 977 QIKETVMYLPKYELKVEQITRYSDTTAEILVTVILRNFEQLQT--------KRTASDSHY 1028
+ P EL E + + S + +V ++ E+ T + + +
Sbjct: 1570 DVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEGWW 1629
Query: 1029 VTLIIGDA-DNQVVYLHKITDSVLLKAGSWAKKIAVKRALKSEDLSINLISSEFVGLDIQ 1087
V +IGDA N ++ + ++T L+ + K V A ++ +S ++G D +
Sbjct: 1630 V--VIGDAKSNSLISIKRLT----LQQKAKVKLDFVAPATGGRHNTLYFMSDAYMGCDQE 1683
Query: 1088 QKLTV 1092
K +V
Sbjct: 1684 YKFSV 1688
>gi|139394648 DNA polymerase theta [Homo sapiens]
Length = 2590
Score = 135 bits (340), Expect = 3e-31
Identities = 120/445 (26%), Positives = 215/445 (48%), Gaps = 57/445 (12%)
Query: 297 RNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGP 356
+N V APT +GKT+V EL I + ++E + K +++ P ++ ++ + F
Sbjct: 109 KNLVYSAPTSAGKTLVAELLILKRVLE-----MRKKALFILPFVSVAKEKKYYLQSLFQE 163
Query: 357 IGLNCKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVQLVRLFLIDEVHIV 416
+G+ G T F I + T E+ + + + + + + L+ + ++DE+H++
Sbjct: 164 VGIKVDGYMGSTSPSRHFS--SLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHML 221
Query: 417 KDENRGPTLEVVVSRMKTVQSVSQTLKN---TSTAIPMRFVAVSATIPNAEDIAEWLSDG 473
D +RG LE++++++ + S + + +S + ++ V +SAT+PN E +A WL+
Sbjct: 222 GDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLN-- 279
Query: 474 ERPAVCLKMDESHRPVKLQ---KVVLGFPCSSNQTEFKFDLTLNYK------IASVIQMY 524
A D RPV L KV SS + +F+ L K ++ +
Sbjct: 280 ---AELYHTD--FRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETI 334
Query: 525 SDQKPTLVFCATRKGVQQAASVLVKDAKFI---------------MTVEQKQRLQ----- 564
D L+FC ++K ++ A ++ ++ + + +EQK+ L+
Sbjct: 335 CDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQL 394
Query: 565 KYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPA 624
+ S DS L+ + G A+HHAG+ +R ++EGAF G + VL TSTL+ GVNLPA
Sbjct: 395 RRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPA 454
Query: 625 HLVVIKSTMHYAGGLFEEYSETDIL---QMIGRAGRPQFDTTATAVIMTRLSTRDKYIQM 681
V+I++ + GG DIL QM+GRAGR DT ++++ + S + K I +
Sbjct: 455 RRVIIRTPIF--GG-----RPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIAL 507
Query: 682 L-ACRDTVESSLHRHLIEHLNAEIV 705
L V S L R E + ++
Sbjct: 508 LQGSLKPVRSCLQRREGEEVTGSMI 532
>gi|110556640 DNA helicase HEL308 [Homo sapiens]
Length = 1101
Score = 115 bits (287), Expect = 4e-25
Identities = 150/654 (22%), Positives = 266/654 (40%), Gaps = 94/654 (14%)
Query: 179 SNDNELDSHIGSVKIVQTEMNKGKSRNYSNSKQKFQYSANVFTANNAFSASEIGEGMFKA 238
S+ N ++ + I Q + N S S + + NA + G +
Sbjct: 226 SSHNTVNEELPHNCIEQPQQNDESSSKVRTSSDMNRRKSIKDHLKNAMT----GNAKAQT 281
Query: 239 PSFSVAFQPHDI---------QEVTENGLGSLKAVTEIPAKFRSIFKEFPYFNYIQSKAF 289
P FS + Q D ++ E+ L +P+K R ++ +F +
Sbjct: 282 PIFSRSKQLKDTLLSEEINVAKKTVESSSNDLGPFYSLPSKVRDLYAQFKGIEKLYEWQH 341
Query: 290 DDLLYTD----RNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQ 345
L +N + PT GKT+V E+ LM L ++ + P A+ +
Sbjct: 342 TCLTLNSVQERKNLIYSLPTSGGKTLVAEI-----LMLQELLCCRKDVLMILPYVAIVQE 396
Query: 346 RFDDWKEKFGPIGLNCKELTGDTV-MDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVQL 404
+ +G +E G + + + T EK S+ + +
Sbjct: 397 KISGLSSFGIELGFFVEEYAGSKGRFPPTKRREKKSLYIATIEKGHSLVNSLIETGRIDS 456
Query: 405 VRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVAVSATIPNAE 464
+ L ++DE+H++ + +RG TLE+ T+ + T K T + + +SAT+ N E
Sbjct: 457 LGLVVVDELHMIGEGSRGATLEM------TLAKILYTSKTT------QIIGMSATLNNVE 504
Query: 465 DIAEWLSDGERPAVCLKMDESHRPVKLQKVV-----LGFPCSSNQTEFKFDLTLNYK--- 516
D+ ++L RPV+L++ + + S + F LNYK
Sbjct: 505 DLQKFLQ-------AEYYTSQFRPVELKEYLKINDTIYEVDSKAENGMTFSRLLNYKYSD 557
Query: 517 -------------IASVIQMYSDQKPTLVFCATRKGVQQAASVLVKD-AKFIMTVEQKQR 562
+ VI YS LVFC ++K + A ++ K +K + ++K++
Sbjct: 558 TLKKMDPDHLVALVTEVIPNYS----CLVFCPSKKNCENVAEMICKFLSKEYLKHKEKEK 613
Query: 563 LQ--KYAYSVRDSKLRDILKD----GAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTL 616
+ K ++ + L +LK G AYHH+G+ +RK++E A++ G L + TSTL
Sbjct: 614 CEVIKNLKNIGNGNLCPVLKRTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTL 673
Query: 617 AMGVNLPAHLVVIKSTMHYAGGLFEEYSETDILQMIGRAGRPQFDTTATAVIMTRLSTRD 676
A GVNLPA V++++ Y F QMIGRAGR DT ++++ L +D
Sbjct: 674 AAGVNLPARRVILRAP--YVAKEF--LKRNQYKQMIGRAGRAGIDTIGESILI--LQEKD 727
Query: 677 KYIQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAVEWIRSTLLYIRALKNPSHYG 736
K Q+L + + HL++ I ++ + + I + L I N + +G
Sbjct: 728 KQ-QVLELITKPLENCYSHLVQEFTKGIQTLFLSLIGLK---IATNLDDIYHFMNGTFFG 783
Query: 737 FASGLNKDGIEAKLQELCLKNLNDLSSLDLIKMDE--------GVNFKPTEAGR 782
+ E L E+ +++L L+ L++ D NF T+ GR
Sbjct: 784 VQQKVLLK--EKSLWEITVESLRYLTEKGLLQKDTIYKSEEEVQYNFHITKLGR 835
>gi|193211480 superkiller viralicidic activity 2-like 2 [Homo
sapiens]
Length = 1042
Score = 114 bits (285), Expect = 7e-25
Identities = 105/442 (23%), Positives = 188/442 (42%), Gaps = 85/442 (19%)
Query: 276 KEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVY 335
KE+P+ + + +++ ++ A T +GKTV E AI L E ++++
Sbjct: 134 KEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQ------RVIF 187
Query: 336 MAPIKALCSQRFDDWKEKFGPIGLNCKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRK 395
+PIKAL +Q++ + E+F +GL +TGD ++ A ++ T E SM
Sbjct: 188 TSPIKALSNQKYREMYEEFQDVGL----MTGDVTINPT-----ASCLVMTTEILRSML-- 236
Query: 396 WRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVA 455
+R + +++ V + DE+H ++D RG E + + + +V
Sbjct: 237 YRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPD---------------NVHYVF 281
Query: 456 VSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNY 515
+SATIPNA AEW+ + C + +RP LQ + FP + D ++
Sbjct: 282 LSATIPNARQFAEWICHLHKQP-CHVIYTDYRPTPLQHYI--FPAGGDGLHLVVDENGDF 338
Query: 516 K----------------------------------IASVIQMYSDQ--KPTLVFCATRKG 539
+ + +++M ++ +P ++F ++K
Sbjct: 339 REDNFNTAMQVLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKD 398
Query: 540 VQQAASVLVKDAKFIMTVEQKQRLQKY------AYSVRDSKLRDI------LKDGAAYHH 587
+ A + K T E+K+ +++ S D KL + LK G HH
Sbjct: 399 CEAYALQMTK--LDFNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHH 456
Query: 588 AGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEEYSETD 647
G+ ++ +E F+ G + LF T T AMG+N+PA V+ + + G F S +
Sbjct: 457 GGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGE 516
Query: 648 ILQMIGRAGRPQFDTTATAVIM 669
+QM GRAGR D ++M
Sbjct: 517 YIQMSGRAGRRGMDDRGIVILM 538
>gi|67782311 superkiller viralicidic activity 2-like homolog [Homo
sapiens]
Length = 1246
Score = 114 bits (285), Expect = 7e-25
Identities = 113/428 (26%), Positives = 183/428 (42%), Gaps = 94/428 (21%)
Query: 301 ICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGPIGLN 360
+ A T +GKTVV E AI + + +Y +PIKAL +Q+F D++ FG +GL
Sbjct: 330 VAAHTSAGKTVVAEYAIALAQKHMT------RTIYTSPIKALSNQKFRDFRNTFGDVGL- 382
Query: 361 CKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVQLVRLFLIDEVHIVKDEN 420
LTGD + A ++ T E SM D +++ + + DEVH + D
Sbjct: 383 ---LTGDVQLHP-----EASCLIMTTEILRSMLYSGSD--VIRDLEWVIFDEVHYINDVE 432
Query: 421 RGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVAVSATIPNAEDIAEWLSDGERPAVCL 480
RG E V+ + S+ + +SAT+PNA + A+W+ +R + +
Sbjct: 433 RGVVWEEVLIMLPDHVSI---------------ILLSATVPNALEFADWIGRLKRRQIYV 477
Query: 481 KMDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNYKIASVIQMY---------------- 524
+ RPV L+ + F +S++T+ + L L+ + A + Y
Sbjct: 478 -ISTVTRPVPLEHYL--FTGNSSKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQ 534
Query: 525 -----------------------------SDQKPTLVFCATRKGVQQAASVLVKDAKFIM 555
Q P +VF +R + AS L + +
Sbjct: 535 TFGAKQPTHQGGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLT--SLDLT 592
Query: 556 TVEQKQR----LQKYAYSVRDSK--------LRDILKDGAAYHHAGMELSDRKVVEGAFT 603
T +K LQ+ +R S + ++L G HH+G+ +++VE F+
Sbjct: 593 TSSEKSEIHLFLQRCLARLRGSDRQLPQVLHMSELLNRGLGVHHSGILPILKEIVEMLFS 652
Query: 604 VGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEEYSETDILQMIGRAGRPQFDTT 663
G + VLF T T AMGVN+PA VV S + G F + + +QM GRAGR D T
Sbjct: 653 RGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPT 712
Query: 664 ATAVIMTR 671
T +++ +
Sbjct: 713 GTVILLCK 720
>gi|222831595 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 [Homo sapiens]
Length = 1712
Score = 56.6 bits (135), Expect = 2e-07
Identities = 38/135 (28%), Positives = 62/135 (45%), Gaps = 8/135 (5%)
Query: 523 MYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQRLQKYAYSVRDSKLRDILKDG 582
++ + LV C K ++ D K + T ++ + + + +L+ + + G
Sbjct: 1202 IHEAEHDNLVKCL-EKNLEIPQDCTYADQKAVDTETLQKVFGRVKFERKGEELKALAERG 1260
Query: 583 AAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEE 642
YHH+ M ++++VE F G L V+ T TLA+GVN+P VV Y L
Sbjct: 1261 IGYHHSAMSFKEKQLVEILFRKGYLRVVTATGTLALGVNMPCKSVVFAQNSVYLDAL--- 1317
Query: 643 YSETDILQMIGRAGR 657
+ QM GRAGR
Sbjct: 1318 ----NYRQMSGRAGR 1328
Score = 52.0 bits (123), Expect = 4e-06
Identities = 48/186 (25%), Positives = 81/186 (43%), Gaps = 33/186 (17%)
Query: 291 DLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDW 350
D++ + + VI APT SGKT + ++L E + +VY+AP KAL +Q
Sbjct: 773 DVVDKNESAVIVAPTSSGKTYASYYCMEKVLKESD----DGVVVYVAPTKALVNQVAATV 828
Query: 351 KEKFGPIGLNCKELTGDTVMDDLFEIQHAH------IIMTTPEKWDSMTRKWRDNSLVQL 404
+ +F K L V+ +F ++ H +++T P ++ + + V+
Sbjct: 829 QNRF------TKNLPSGEVLCGVFTREYRHDALNCQVLITVPACFEILLLAPHRQNWVKK 882
Query: 405 VRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVAVSATIPNAE 464
+R + DEVH + E E ++ I F+A+SATI N E
Sbjct: 883 IRYVIFDEVHCLGGEIGAEIWEHLL-----------------VMIRCPFLALSATISNPE 925
Query: 465 DIAEWL 470
+ EWL
Sbjct: 926 HLTEWL 931
>gi|149274648 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like [Homo
sapiens]
Length = 1706
Score = 50.1 bits (118), Expect = 2e-05
Identities = 29/95 (30%), Positives = 47/95 (49%), Gaps = 7/95 (7%)
Query: 563 LQKYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNL 622
L + ++ +L+ + + G YHH+ M +++ VE F G + V+ T TLA+G+++
Sbjct: 1225 LPRVRFTRHGKELKALAQRGIGYHHSSMYFKEKEFVEILFVKGLIRVVTATETLALGIHM 1284
Query: 623 PAHLVVIKSTMHYAGGLFEEYSETDILQMIGRAGR 657
P VV Y L + QM GRAGR
Sbjct: 1285 PCKSVVFAQDSVYLDAL-------NYRQMSGRAGR 1312
Score = 49.7 bits (117), Expect = 2e-05
Identities = 43/180 (23%), Positives = 76/180 (42%), Gaps = 21/180 (11%)
Query: 291 DLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDW 350
D++ + + VI APT SGKT + ++L E + +VY+AP K+L Q
Sbjct: 753 DVVDKNESAVIVAPTSSGKTYASYYCMEKVLRESDVG----VVVYVAPAKSLVGQVAATV 808
Query: 351 KEKFGPIGLNCKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVQLVRLFLI 410
+ +F + L G D + + +++T PE ++ + V+ +R +
Sbjct: 809 ENRFTKTLPAGRTLCGAFTRDYCHNVLNCQVLITVPECFEILLLAPHRQKWVERIRYVIF 868
Query: 411 DEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVAVSATIPNAEDIAEWL 470
DEVH + E E+++ I F+ +SATI N + +WL
Sbjct: 869 DEVHYLGREVGAKFWELLL-----------------VIIRCPFLVLSATINNPNLLTKWL 911
>gi|51094101 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 2
[Homo sapiens]
Length = 881
Score = 44.7 bits (104), Expect = 7e-04
Identities = 91/458 (19%), Positives = 167/458 (36%), Gaps = 88/458 (19%)
Query: 228 ASEIGEGMFKAPSFSVAFQPHDIQEVTENGLGSLKAVTEIPAKFRSIFKEFPYFNYIQSK 287
A ++G G P+F + D++ T + + + F+S+ +P F I K
Sbjct: 56 ARKLGPGR-PLPTFPTSECTSDVEPDTREMVRAQNKKKKKSGGFQSMGLSYPVFKGIMKK 114
Query: 288 AFD----------DLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMA 337
+ ++ ++ V A TGSGKT F L + L + + + ++
Sbjct: 115 GYKVPTPIQRKTIPVILDGKDVVAMARTGSGKTACFLLPMFERL-KTHSAQTGARALILS 173
Query: 338 PIKALCSQRFDDWKEKFGPIGLNCKELTGDTVMDDLFEIQHAH--IIMTTPEKWDSMTRK 395
P + L Q KE GL + G M+D F H + II+ TP + + +
Sbjct: 174 PTRELALQTLKFTKELGKFTGLKTALILGGDRMEDQFAALHENPDIIIATPGRLVHVAVE 233
Query: 396 WRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVA 455
+ +Q V + DE + + L+ +++R+ V
Sbjct: 234 M--SLKLQSVEYVVFDEADRLFEMGFAEQLQEIIARLPGGHQT---------------VL 276
Query: 456 VSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNY 515
SAT+P + E+ G V +++D + + Q + F L
Sbjct: 277 FSATLPKL--LVEFARAGLTEPVLIRLDVDTK-------------LNEQLKTSFFLVRED 321
Query: 516 KIASVI-----QMYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQRLQKYAYSV 570
A+V+ + Q T+VF AT+ A+++ + QR+
Sbjct: 322 TKAAVLLHLLHNVVRPQDQTVVFVATK-----------HHAEYLTELLTTQRV------- 363
Query: 571 RDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIK 630
A+ ++ ++ + RK+ FT+G L T A G+++P VI
Sbjct: 364 -----------SCAHIYSALDPTARKINLAKFTLGKCSTLIVTDLAARGLDIPLLDNVIN 412
Query: 631 STMHYAGGLFEEYSETDILQMIGRAGRPQFDTTATAVI 668
+ G LF L +GR R TA +++
Sbjct: 413 YSFPAKGKLF--------LHRVGRVARAGRSGTAYSLV 442
>gi|164419743 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 1
[Homo sapiens]
Length = 882
Score = 44.7 bits (104), Expect = 7e-04
Identities = 91/458 (19%), Positives = 167/458 (36%), Gaps = 88/458 (19%)
Query: 228 ASEIGEGMFKAPSFSVAFQPHDIQEVTENGLGSLKAVTEIPAKFRSIFKEFPYFNYIQSK 287
A ++G G P+F + D++ T + + + F+S+ +P F I K
Sbjct: 56 ARKLGPGR-PLPTFPTSECTSDVEPDTREMVRAQNKKKKKSGGFQSMGLSYPVFKGIMKK 114
Query: 288 AFD----------DLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMA 337
+ ++ ++ V A TGSGKT F L + L + + + ++
Sbjct: 115 GYKVPTPIQRKTIPVILDGKDVVAMARTGSGKTACFLLPMFERL-KTHSAQTGARALILS 173
Query: 338 PIKALCSQRFDDWKEKFGPIGLNCKELTGDTVMDDLFEIQHAH--IIMTTPEKWDSMTRK 395
P + L Q KE GL + G M+D F H + II+ TP + + +
Sbjct: 174 PTRELALQTLKFTKELGKFTGLKTALILGGDRMEDQFAALHENPDIIIATPGRLVHVAVE 233
Query: 396 WRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVA 455
+ +Q V + DE + + L+ +++R+ V
Sbjct: 234 M--SLKLQSVEYVVFDEADRLFEMGFAEQLQEIIARLPGGHQT---------------VL 276
Query: 456 VSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNY 515
SAT+P + E+ G V +++D + + Q + F L
Sbjct: 277 FSATLPKL--LVEFARAGLTEPVLIRLDVDTK-------------LNEQLKTSFFLVRED 321
Query: 516 KIASVI-----QMYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQRLQKYAYSV 570
A+V+ + Q T+VF AT+ A+++ + QR+
Sbjct: 322 TKAAVLLHLLHNVVRPQDQTVVFVATK-----------HHAEYLTELLTTQRV------- 363
Query: 571 RDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIK 630
A+ ++ ++ + RK+ FT+G L T A G+++P VI
Sbjct: 364 -----------SCAHIYSALDPTARKINLAKFTLGKCSTLIVTDLAARGLDIPLLDNVIN 412
Query: 631 STMHYAGGLFEEYSETDILQMIGRAGRPQFDTTATAVI 668
+ G LF L +GR R TA +++
Sbjct: 413 YSFPAKGKLF--------LHRVGRVARAGRSGTAYSLV 442
>gi|90819229 cutaneous T-cell lymphoma-associated antigen 1 isoform 1
[Homo sapiens]
Length = 745
Score = 42.0 bits (97), Expect = 0.004
Identities = 48/189 (25%), Positives = 88/189 (46%), Gaps = 25/189 (13%)
Query: 902 QEKKFAVLLNSLILAKCFRCKLWENSLHVSKQLEKIGITLSNAIVNAGLTSFKKIEETDA 961
+EKKFAV L+ LI K CKL E V K+ E G + +++ NA SF+K E T+A
Sbjct: 44 REKKFAVALSGLIEEK---CKLLEKFSLVQKEYE--GYEVESSLKNA---SFEK-EATEA 94
Query: 962 RELELILNRHPPFGTQIKETVMYLPKYELKVEQITRYSDTTAEILVTVILRNFE------ 1015
+ LE + F +++ ++ L K ELK E+ ++ +++ E
Sbjct: 95 QSLEATCEKLNRFNSELVHEILCLEK-ELKEEKSKHSEQNELMADISKRIQSLEDESKSL 153
Query: 1016 -------QLQTKRTASDSHYVTLIIGDADNQVVYLHKITDSVLLKAGSWAKKIA--VKRA 1066
++ KR ++ + + I DA + L + +L +A W ++++ +K+
Sbjct: 154 KSQVAEAKMTFKRFQANEERLEIEIQDAWKENSELQESQKQLLQEAEVWKEQVSELIKQK 213
Query: 1067 LKSEDLSIN 1075
ED ++
Sbjct: 214 RTFEDSKVH 222
>gi|116812616 RecQ protein-like 4 [Homo sapiens]
Length = 1208
Score = 41.6 bits (96), Expect = 0.006
Identities = 87/370 (23%), Positives = 146/370 (39%), Gaps = 73/370 (19%)
Query: 300 VICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKE--KFGPI 357
++ PTG+GK++ ++L LL P L + + +P+ +L + K I
Sbjct: 499 LLVLPTGAGKSLCYQLPA--LLYSRRSPCLTLVV---SPLLSLMDDQVSGLPPCLKAACI 553
Query: 358 GLNCKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVQL--VRLFLIDEVHI 415
++V+ + Q H++M TPE ++ QL V IDE H
Sbjct: 554 HSGMTRKQRESVLQKIRAAQ-VHVLMLTPE---ALVGAGGLPPAAQLPPVAFACIDEAHC 609
Query: 416 VKD--ENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVAVSATIPNAEDIAEWLSDG 473
+ N P V ++ V L T+TA T A D+A+ L+
Sbjct: 610 LSQWSHNFRPCYLRVCKVLRERMGVHCFLGLTATA----------TRRTASDVAQHLAVA 659
Query: 474 ERPAVCLKMDESHRPVKLQKVVLGFPCSSN-QTEFKFDLTLNYKIASVIQ--MYSDQKPT 530
E P + H P P +N D + + +++Q + +
Sbjct: 660 EEP-------DLHGPA---------PVPTNLHLSVSMDRDTDQALLTLLQGKRFQNLDSI 703
Query: 531 LVFCATRKGVQQAASVLVKDAKFIMTVEQKQRLQKYAYSVRDSKLRDILKDGAAYHHAGM 590
+++C R+ ++ A++L R +A V S R K A +HAGM
Sbjct: 704 IIYCNRREDTERIAALL--------------RTCLHAAWVPGSGGR-APKTTAEAYHAGM 748
Query: 591 ELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGL---FEEYSETD 647
+R+ V+ AF G L V+ T MG++ P +++ +H GL FE Y
Sbjct: 749 CSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPD----VRAVLHL--GLPPSFESY---- 798
Query: 648 ILQMIGRAGR 657
+Q +GRAGR
Sbjct: 799 -VQAVGRAGR 807
>gi|31542656 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 [Homo
sapiens]
Length = 483
Score = 41.6 bits (96), Expect = 0.006
Identities = 34/118 (28%), Positives = 55/118 (46%), Gaps = 6/118 (5%)
Query: 297 RNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGP 356
R+ + CA TGSGKT F L I + L E P I + + P + L Q + ++ P
Sbjct: 40 RDCLGCAKTGSGKTAAFVLPILQKLSEDP---YGIFCLVLTPTRELAYQIAEQFRVLGKP 96
Query: 357 IGLNCKELTG--DTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVQLVRLFLIDE 412
+GL + G D V L + H+++ TP + R S ++ +R ++DE
Sbjct: 97 LGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTFS-IKKIRFLVMDE 153
>gi|38327634 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 [Homo
sapiens]
Length = 670
Score = 41.2 bits (95), Expect = 0.007
Identities = 66/235 (28%), Positives = 98/235 (41%), Gaps = 42/235 (17%)
Query: 125 SQKYKNHIGTEIAPEKSVPDDTKLVNFAEDKGESTSVFRKRLFKISDNIHGSAYSNDNEL 184
SQ+ +I +P+KS T L N S S +K+ K + ND E
Sbjct: 74 SQEAVGNIKVTKSPQKS----TVLTNGEAAMQSSNSESKKKKKKKRKMV------NDAEP 123
Query: 185 DSHIGSVKIVQTEMNKGKSRNYSNSKQKFQYSANVFTANNAFSASEIGE------GMFKA 238
D+ K +TE NKGKS S K + NV +N SE+ G F+
Sbjct: 124 DT-----KKAKTE-NKGKSEEESAETTK-ETENNVEKPDNDEDESEVPSLPLGLTGAFED 176
Query: 239 PSFSVAFQPHDIQEVTENGLGSLKAVTEIPAKFRSIFKEFPYFNYIQSKAFDDLLYTDRN 298
SF+ V EN +LKA+ E+ F IQ K+ LL R+
Sbjct: 177 TSFASL-----CNLVNEN---TLKAIKEMG---------FTNMTEIQHKSIRPLL-EGRD 218
Query: 299 FVICAPTGSGKTVVFELAITRLLMEVP-LPWLNIKIVYMAPIKALCSQRFDDWKE 352
+ A TGSGKT+ F + L++++ +P ++ ++P + L Q F KE
Sbjct: 219 LLAAAKTGSGKTLAFLIPAVELIVKLRFMPRNGTGVLILSPTRELAMQTFGVLKE 273
>gi|13129006 nucleolar protein GU2 [Homo sapiens]
Length = 737
Score = 40.8 bits (94), Expect = 0.009
Identities = 76/364 (20%), Positives = 141/364 (38%), Gaps = 69/364 (18%)
Query: 280 YFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLL---MEVPLPWLNIKIVYM 336
Y IQ K F + Y ++ + A TG+GKT F + + L E + K++ +
Sbjct: 159 YLFPIQVKTFGPV-YEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVL 217
Query: 337 APIKALCSQRFDDWKEKFGPIGLNCKELTGDTVMDDLFEIQHA-HIIMTTPEKWDSMTRK 395
AP + L +Q D+K+ + + C G + + I++ I++ TP + +
Sbjct: 218 APTRELANQVAKDFKDITRKLSVAC-FYGGTSYQSQINHIRNGIDILVGTPGRIKDHLQS 276
Query: 396 WRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVA 455
R + + +R ++DEV + D +E + + ++ K S P +
Sbjct: 277 GRLD--LSKLRHVVLDEVDQMLDLGFAEQVEDI---------IHESYKTDSEDNPQTLL- 324
Query: 456 VSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKL-QKVV-----LGFPCSSNQTEFKF 509
SAT P +W+ + + + ++ K+ QK L C +Q
Sbjct: 325 FSATCP------QWVYKVAKKYMKSRYEQVDLVGKMTQKAATTVEHLAIQCHWSQRP--- 375
Query: 510 DLTLNYKIASVIQMYS-DQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQRLQKYAY 568
I V+Q+YS + ++FC T+K V + A
Sbjct: 376 -----AVIGDVLQVYSGSEGRAIIFCETKKNVTEMA------------------------ 406
Query: 569 SVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVV 628
+ +K A H + S R++ F G VL T+ A G+++P +V
Sbjct: 407 ------MNPHIKQNAQCLHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLV 460
Query: 629 IKST 632
I+S+
Sbjct: 461 IQSS 464
>gi|110735439 Werner syndrome protein [Homo sapiens]
Length = 1432
Score = 39.7 bits (91), Expect = 0.021
Identities = 76/380 (20%), Positives = 133/380 (35%), Gaps = 74/380 (19%)
Query: 281 FNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIK 340
F +Q K +L R+ V TG GK++ F+ P ++ + ++P+
Sbjct: 549 FKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQY---------PPVYVGKIGLVISPLI 599
Query: 341 ALCSQRFDDWKEKFGPIGLNCKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNS 400
+L + K P + V+ D+ ++ I+ TPE +
Sbjct: 600 SLMEDQVLQLKMSNIPACF-LGSAQSENVLTDI-KLGKYRIVYVTPEYCSGNMGLLQQLE 657
Query: 401 LVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPM-RFVAVSAT 459
+ L +DE H + + + + L + TA+PM VA++AT
Sbjct: 658 ADIGITLIAVDEAHCISEWGHD------------FRDSFRKLGSLKTALPMVPIVALTAT 705
Query: 460 IPNA--EDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNYKI 517
++ EDI L+ C D + +++++ + N + L +
Sbjct: 706 ASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRK------TGNILQ-----DLQPFL 754
Query: 518 ASVIQMYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQRLQKYAYSVRDSKLRD 577
+ + PT+++C +RK QQ L K
Sbjct: 755 VKTSSHWEFEGPTIIYCPSRKMTQQVTGELRK---------------------------- 786
Query: 578 ILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAG 637
L +HAGM S RK + F ++ + T MG+N I+ +HY
Sbjct: 787 -LNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGIN----KADIRQVIHYGA 841
Query: 638 GLFEEYSETDILQMIGRAGR 657
E Q IGRAGR
Sbjct: 842 PKDME----SYYQEIGRAGR 857
>gi|169218196 PREDICTED: similar to Werner syndrome ATP-dependent
helicase, partial [Homo sapiens]
Length = 1140
Score = 39.7 bits (91), Expect = 0.021
Identities = 76/380 (20%), Positives = 133/380 (35%), Gaps = 74/380 (19%)
Query: 281 FNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIK 340
F +Q K +L R+ V TG GK++ F+ P ++ + ++P+
Sbjct: 257 FKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQY---------PPVYVGKIGLVISPLI 307
Query: 341 ALCSQRFDDWKEKFGPIGLNCKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNS 400
+L + K P + V+ D+ ++ I+ TPE +
Sbjct: 308 SLMEDQVLQLKMSNIPACF-LGSAQSENVLTDI-KLGKYRIVYVTPEYCSGNMGLLQQLE 365
Query: 401 LVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPM-RFVAVSAT 459
+ L +DE H + + + + L + TA+PM VA++AT
Sbjct: 366 ADIGITLIAVDEAHCISEWGHD------------FRDSFRKLGSLKTALPMVPIVALTAT 413
Query: 460 IPNA--EDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNYKI 517
++ EDI L+ C D + +++++ + N + L +
Sbjct: 414 ASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRK------TGNILQ-----DLQPFL 462
Query: 518 ASVIQMYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQRLQKYAYSVRDSKLRD 577
+ + PT+++C +RK QQ L K
Sbjct: 463 VKTSSHWEFEGPTIIYCPSRKMTQQVTGELRK---------------------------- 494
Query: 578 ILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAG 637
L +HAGM S RK + F ++ + T MG+N I+ +HY
Sbjct: 495 -LNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGIN----KADIRQVIHYGA 549
Query: 638 GLFEEYSETDILQMIGRAGR 657
E Q IGRAGR
Sbjct: 550 PKDME----SYYQEIGRAGR 565
>gi|209862869 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 3
[Homo sapiens]
Length = 724
Score = 39.7 bits (91), Expect = 0.021
Identities = 75/375 (20%), Positives = 141/375 (37%), Gaps = 71/375 (18%)
Query: 292 LLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIK------IVYMAPIKALCSQ 345
++ R+ + CA TGSGKT F L I +M + K + +AP + L +Q
Sbjct: 321 IILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECIIVAPTRELVNQ 380
Query: 346 RF-DDWKEKFGPIGLNCKELTGDTVMDDLFE--IQHAHIIMTTPEKWDSMTRKWRDNSLV 402
+ + K FG + + G T + +Q +I+ TP + + K + +
Sbjct: 381 IYLEARKFSFGTC-VRAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDIIGK--EKIGL 437
Query: 403 QLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVAVSATIPN 462
+ ++ ++DE + D GP ++ ++S + S P ++A
Sbjct: 438 KQIKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLMFSATFPEEIQRLAAEFLK 497
Query: 463 AEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNYKIASVIQ 522
+ + +++ G+ C R V+ + +G + K+ +++
Sbjct: 498 SNYL--FVAVGQVGGAC-------RDVQQTVLQVG------------QFSKREKLVEILR 536
Query: 523 MYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQRLQKYAYSVRDSKLRDILKDG 582
D++ T+VF T+ K A FI T ++++ +
Sbjct: 537 NIGDER-TMVFVETK-----------KKADFIATFLCQEKISTTSI-------------- 570
Query: 583 AAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEE 642
H E +R+ G F G PVL TS A G+++ VI + +E
Sbjct: 571 ----HGDREQREREQALGDFRFGKCPVLVATSVAARGLDIENVQHVINFDL---PSTIDE 623
Query: 643 YSETDILQMIGRAGR 657
Y + IGR GR
Sbjct: 624 Y-----VHRIGRTGR 633
>gi|13518015 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 1
[Homo sapiens]
Length = 724
Score = 39.7 bits (91), Expect = 0.021
Identities = 75/375 (20%), Positives = 141/375 (37%), Gaps = 71/375 (18%)
Query: 292 LLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIK------IVYMAPIKALCSQ 345
++ R+ + CA TGSGKT F L I +M + K + +AP + L +Q
Sbjct: 321 IILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECIIVAPTRELVNQ 380
Query: 346 RF-DDWKEKFGPIGLNCKELTGDTVMDDLFE--IQHAHIIMTTPEKWDSMTRKWRDNSLV 402
+ + K FG + + G T + +Q +I+ TP + + K + +
Sbjct: 381 IYLEARKFSFGTC-VRAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDIIGK--EKIGL 437
Query: 403 QLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVAVSATIPN 462
+ ++ ++DE + D GP ++ ++S + S P ++A
Sbjct: 438 KQIKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLMFSATFPEEIQRLAAEFLK 497
Query: 463 AEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNYKIASVIQ 522
+ + +++ G+ C R V+ + +G + K+ +++
Sbjct: 498 SNYL--FVAVGQVGGAC-------RDVQQTVLQVG------------QFSKREKLVEILR 536
Query: 523 MYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQRLQKYAYSVRDSKLRDILKDG 582
D++ T+VF T+ K A FI T ++++ +
Sbjct: 537 NIGDER-TMVFVETK-----------KKADFIATFLCQEKISTTSI-------------- 570
Query: 583 AAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEE 642
H E +R+ G F G PVL TS A G+++ VI + +E
Sbjct: 571 ----HGDREQREREQALGDFRFGKCPVLVATSVAARGLDIENVQHVINFDL---PSTIDE 623
Query: 643 YSETDILQMIGRAGR 657
Y + IGR GR
Sbjct: 624 Y-----VHRIGRTGR 633
>gi|216548263 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 2
[Homo sapiens]
Length = 690
Score = 39.7 bits (91), Expect = 0.021
Identities = 75/375 (20%), Positives = 141/375 (37%), Gaps = 71/375 (18%)
Query: 292 LLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIK------IVYMAPIKALCSQ 345
++ R+ + CA TGSGKT F L I +M + K + +AP + L +Q
Sbjct: 287 IILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECIIVAPTRELVNQ 346
Query: 346 RF-DDWKEKFGPIGLNCKELTGDTVMDDLFE--IQHAHIIMTTPEKWDSMTRKWRDNSLV 402
+ + K FG + + G T + +Q +I+ TP + + K + +
Sbjct: 347 IYLEARKFSFGTC-VRAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDIIGK--EKIGL 403
Query: 403 QLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVAVSATIPN 462
+ ++ ++DE + D GP ++ ++S + S P ++A
Sbjct: 404 KQIKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLMFSATFPEEIQRLAAEFLK 463
Query: 463 AEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNYKIASVIQ 522
+ + +++ G+ C R V+ + +G + K+ +++
Sbjct: 464 SNYL--FVAVGQVGGAC-------RDVQQTVLQVG------------QFSKREKLVEILR 502
Query: 523 MYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQRLQKYAYSVRDSKLRDILKDG 582
D++ T+VF T+ K A FI T ++++ +
Sbjct: 503 NIGDER-TMVFVETK-----------KKADFIATFLCQEKISTTSI-------------- 536
Query: 583 AAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEE 642
H E +R+ G F G PVL TS A G+++ VI + +E
Sbjct: 537 ----HGDREQREREQALGDFRFGKCPVLVATSVAARGLDIENVQHVINFDL---PSTIDE 589
Query: 643 YSETDILQMIGRAGR 657
Y + IGR GR
Sbjct: 590 Y-----VHRIGRTGR 599
>gi|74959747 Fanconi anemia, complementation group M [Homo sapiens]
Length = 2048
Score = 39.3 bits (90), Expect = 0.028
Identities = 26/91 (28%), Positives = 43/91 (47%), Gaps = 5/91 (5%)
Query: 298 NFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGPI 357
N ++C PTG GKT + + + P + K+V+MAP K L +Q+ + + G
Sbjct: 106 NTLVCLPTGLGKTFIAAVVMYNFYRWFP----SGKVVFMAPTKPLVTQQIEACYQVMGIP 161
Query: 358 GLNCKELTGDTVMDDLFEIQ-HAHIIMTTPE 387
+ E+TG T EI ++ TP+
Sbjct: 162 QSHMAEMTGSTQASTRKEIWCSKRVLFLTPQ 192
>gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo
sapiens]
Length = 1031
Score = 39.3 bits (90), Expect = 0.028
Identities = 138/649 (21%), Positives = 235/649 (36%), Gaps = 126/649 (19%)
Query: 47 DTQELEEELESHKLLGQ---EKRPKMLTSNLKITNEDTNYISLTQKFQFAFPSDKYEQDD 103
D +LEEE+ K + E++ K N+ ++ + +K+ D E D
Sbjct: 152 DQNKLEEEMRKRKERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDD-EDDP 210
Query: 104 LNLEGVGNNDLSHIAGKLTYASQKYKNHI---------GTEIAPEKSVPDDTKLVNFAED 154
E GN L ++ K + G +KS P TK+V
Sbjct: 211 AEAEKEGNEMEGEELDPLDAYMEEVKEEVKKFNMRSVKGGGGNEKKSGPTVTKVV----- 265
Query: 155 KGESTSVFRKRLFKISDNIHGSAYSNDNELDSHIGSVKIV--QTEMN--KGKSRNYSNSK 210
T V K+ SD G ND + + + V QT + + K R
Sbjct: 266 ----TVVTTKKAVVDSDKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPV 321
Query: 211 QKFQYSANVFTANNAFSASEIGEGMFKAPSFSVAFQPHDIQEVTENGLGSLKAVTE---- 266
+ F N E+ K V +++ +T G G K +
Sbjct: 322 DHGKIEYEPFRKNFYVEVPELA----KMSQEEVNVFRLEMEGITVKGKGCPKPIKSWVQC 377
Query: 267 -IPAKFRSIFKEFPYFNY--IQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLM- 322
I K + K+ Y IQ++A ++ + R+ + A TGSGKT+ F L + R +M
Sbjct: 378 GISMKILNSLKKHGYEKPTPIQTQAIPAIM-SGRDLIGIAKTGSGKTIAFLLPMFRHIMD 436
Query: 323 -------EVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGPIGLNCKELTGDT-VMDDLF 374
E P+ V M P + L Q + K+ +GL + G T + + +
Sbjct: 437 QRSLEEGEGPI------AVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIA 490
Query: 375 EIQH-AHIIMTTPEKWDSMTRKWRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMK 433
E++ A II+ TP + M + L R+ ++V DE RM
Sbjct: 491 ELKRGAEIIVCTPGRMIDMLAA-NSGRVTNLRRV-----TYVVLDE---------ADRMF 535
Query: 434 TVQSVSQTLKNTSTAIPMR-FVAVSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQ 492
+ Q ++ P R V SAT P A + L +P+++Q
Sbjct: 536 DMGFEPQVMRIVDNVRPDRQTVMFSATFPRAME-------------ALARRILSKPIEVQ 582
Query: 493 KVVLGFPCSSNQTEFKFDLTLNYKIASVIQMYSDQKPTLVFCATRKGVQQAASVLVKDAK 552
CS + + + ++K L Q++ SV++ K
Sbjct: 583 VGGRSVVCSD--------------VEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDK 628
Query: 553 FIMTVEQKQRLQKYAYSVRDSKLRDILKDGAAYH----HAGMELSDRKVVEGAFTVGDLP 608
Q++A D L+D+++ A+Y H G++ DR + F G
Sbjct: 629 -----------QEHA----DGLLKDLMR--ASYPCMSLHGGIDQYDRDSIINDFKNGTCK 671
Query: 609 VLFTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEEYSETDILQMIGRAGR 657
+L TS A G+++ HL+++ + + +E+Y + GR GR
Sbjct: 672 LLVATSVAARGLDV-KHLILVVN--YSCPNHYEDY-----VHRAGRTGR 712
>gi|41327776 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 isoform 2
[Homo sapiens]
Length = 406
Score = 38.5 bits (88), Expect = 0.047
Identities = 27/92 (29%), Positives = 43/92 (46%), Gaps = 5/92 (5%)
Query: 297 RNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGP 356
R+ + A TGSGKT F L I L+E P + + + P + L Q + ++
Sbjct: 62 RDIIGLAETGSGKTGAFALPILNALLETP---QRLFALVLTPTRELAFQISEQFEALGSS 118
Query: 357 IGLNCKELTG--DTVMDDLFEIQHAHIIMTTP 386
IG+ + G D++ L + HII+ TP
Sbjct: 119 IGVQSAVIVGGIDSMSQSLALAKKPHIIIATP 150
>gi|20149629 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 isoform 1
[Homo sapiens]
Length = 455
Score = 38.5 bits (88), Expect = 0.047
Identities = 27/92 (29%), Positives = 43/92 (46%), Gaps = 5/92 (5%)
Query: 297 RNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGP 356
R+ + A TGSGKT F L I L+E P + + + P + L Q + ++
Sbjct: 62 RDIIGLAETGSGKTGAFALPILNALLETP---QRLFALVLTPTRELAFQISEQFEALGSS 118
Query: 357 IGLNCKELTG--DTVMDDLFEIQHAHIIMTTP 386
IG+ + G D++ L + HII+ TP
Sbjct: 119 IGVQSAVIVGGIDSMSQSLALAKKPHIIIATP 150
>gi|27881482 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I
[Homo sapiens]
Length = 925
Score = 37.0 bits (84), Expect = 0.14
Identities = 34/120 (28%), Positives = 55/120 (45%), Gaps = 4/120 (3%)
Query: 297 RNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFGP 356
+N +ICAPTG GKT V L L + P K+V+ A + Q+ + + F
Sbjct: 258 KNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKG-KVVFFANQIPVYEQQKSVFSKYFER 316
Query: 357 IGLNCKELTGDTVMDDLFE--IQHAHIIMTTPEKWDSMTRKWRDNSLVQLVRLFLIDEVH 414
G ++G T + E +++ II+ TP+ + +K SL + L + DE H
Sbjct: 317 HGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTIPSL-SIFTLMIFDECH 375
>gi|188035877 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 [Homo
sapiens]
Length = 619
Score = 36.6 bits (83), Expect = 0.18
Identities = 88/385 (22%), Positives = 146/385 (37%), Gaps = 89/385 (23%)
Query: 297 RNFVICAPTGSGKTVVFEL-AITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKFG 355
R+ + A TGSGKT F L I R L E P + + P + L Q KE
Sbjct: 241 RDILASADTGSGKTAAFLLPVIMRALFESKTP----SALILTPTRELAIQIERQAKELMS 296
Query: 356 --PIGLNCKELTGDTVMDDLFEI-QHAHIIMTTPEKWDSMTRKWRDNSLVQL--VRLFLI 410
P + G + L+ + QH +I+ TP + + ++ S V+L V++ ++
Sbjct: 297 GLPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQ----SSVELCGVKIVVV 352
Query: 411 DEVHIVKDENRGPTLEVVVSRMKTVQSVSQTLKNTSTAIPMRFVAVSATIPNA-EDIAEW 469
DE + +M Q V L+N + + VSATIP + E +A
Sbjct: 353 DEAD-------------TMLKMGFQQQVLDILENIPN--DCQTILVSATIPTSIEQLASQ 397
Query: 470 LSDGERPAVCLKMDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNYKIASVIQMYSDQK- 528
L H PV++ PC +N + + K + ++ +D+K
Sbjct: 398 L--------------LHNPVRIITGEKNLPC-ANVRQIILWVEDPAKKKKLFEILNDKKL 442
Query: 529 ---PTLVFCATRKGVQQAASVLVK--DAKFIMTVEQKQRLQKYAYSVRDSKLRDILKDGA 583
P LVF + G + + K K I +K ++++ ++ILK
Sbjct: 443 FKPPVLVFVDCKLGADLLSEAVQKITGLKSISIHSEKSQIER----------KNILK--- 489
Query: 584 AYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEEY 643
GD V+ +T L G++L + +V+ M + +EY
Sbjct: 490 -----------------GLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSS---MDEY 529
Query: 644 SETDILQMIGRAGRPQFDTTATAVI 668
+ IGR GR + TA I
Sbjct: 530 -----VHQIGRVGRLGQNGTAITFI 549
>gi|41327779 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 [Homo
sapiens]
Length = 600
Score = 36.6 bits (83), Expect = 0.18
Identities = 39/153 (25%), Positives = 67/153 (43%), Gaps = 15/153 (9%)
Query: 278 FPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLM--EVPLPWLNIKIVY 335
FPY +QS L +++ A TGSGKT+ F + I +L+ E L + +
Sbjct: 29 FPYMTPVQSATIP-LFMRNKDVAAEAVTGSGKTLAFVIPILEILLRREEKLKKSQVGAII 87
Query: 336 MAPIKALCSQ------RFDDWKEKFGPIGLNCKELTGDTVMDDLFEIQHAHIIMTTPEKW 389
+ P + L Q F +F I G+ V + F+ Q +II+ TP +
Sbjct: 88 ITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDV--ERFKQQGGNIIVATPGRL 145
Query: 390 DSMTRKWRDN----SLVQLVRLFLIDEVHIVKD 418
+ M R+ + S V+ + + ++DE + D
Sbjct: 146 EDMFRRKAEGLDLASCVRSLDVLVLDEADRLLD 178
>gi|154350236 hypothetical protein LOC56204 [Homo sapiens]
Length = 1076
Score = 36.2 bits (82), Expect = 0.23
Identities = 47/250 (18%), Positives = 105/250 (42%), Gaps = 23/250 (9%)
Query: 1109 KSETQISHSKHSDISTIAG-----PNKGTTASKKPGNRECNHLCKSKHTCGHDCCKIGVA 1163
+S ISH+K S + I+ PNK T+ K +C+ ++++ C ++ +I +
Sbjct: 537 ESSVSISHTKCSLLGDISDGKNLVPNKCFTSFKNNSKEKCSLKHQTRNQCQNNPSEIIQS 596
Query: 1164 QKSEIKESTISSYLSDLRNRNAVSSVPPVKRLKIQMNKSQSVDLKEFGFTPKPSLPSISR 1223
E + + S S + +++ +++ R K + S +D K++ + +I +
Sbjct: 597 TYQETQNKSSSLSTSSILSQHKENNLDLTSRFK-EQEMSNGID-KQYS-----NCTTIDK 649
Query: 1224 SEYLNISELPIMEQWDQPEIYGKVRQEPSEYQDKEVLNVNFELGNEVWDDFD--DENLEV 1281
N + I+ + P+ +G ++ + S+ D ++ E+ +E + ++ N +
Sbjct: 650 QICTNKYKEKIINENYNPKFFGNLQSDDSKKNDSKIKVTVLEM-SEYLNKYESMSSNKDS 708
Query: 1282 TSFSTDTEKTKISGFGNTLSSSTRGSKLPL-------QESKSKFQREMSNSFVSSHEMSD 1334
T + T+++ N L+ G K Q+ + E S ++ + D
Sbjct: 709 KRPKTCEQNTQLNSIENYLNKDNEGFKCKKSDQLKNEQDKQEDPTNEKSQNYSQRRSIKD 768
Query: 1335 ISLSNSAMPK 1344
LS PK
Sbjct: 769 -CLSTCEQPK 777
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,986,352
Number of Sequences: 37866
Number of extensions: 2143109
Number of successful extensions: 5883
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 5751
Number of HSP's gapped (non-prelim): 107
length of query: 1435
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1320
effective length of database: 13,892,928
effective search space: 18338664960
effective search space used: 18338664960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.