Search of human proteins with 13027802

Search of human proteins with 13027802

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
[Homo sapiens]
         (607 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ...  1303   0.0  
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein...   872   0.0  
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]   856   0.0  
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]   705   0.0  
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]   674   0.0  
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi...   370   e-102
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap...   358   1e-98
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]    311   1e-84
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]    307   2e-83
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]   303   2e-82
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi...   300   3e-81
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi...   295   1e-79
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H...   290   3e-78
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]   285   9e-77
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]      283   3e-76
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi...   275   7e-74
gi|73808268 matrix metalloproteinase 27 [Homo sapiens]                259   7e-69
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot...   252   8e-67
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ...   244   2e-64
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]      216   5e-56
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [...   216   5e-56
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]    180   3e-45
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi...   142   7e-34
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]   140   3e-33
gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi...   130   5e-30
gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]      101   2e-21
gi|88853069 vitronectin precursor [Homo sapiens]                       79   9e-15
gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]           79   2e-14
gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ...    76   8e-14
gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]           76   8e-14

>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
           [Homo sapiens]
          Length = 607

 Score = 1303 bits (3372), Expect = 0.0
 Identities = 607/607 (100%), Positives = 607/607 (100%)

Query: 1   MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRM 60
           MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRM
Sbjct: 1   MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRM 60

Query: 61  SVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRY 120
           SVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRY
Sbjct: 61  SVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRY 120

Query: 121 ALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKR 180
           ALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKR
Sbjct: 121 ALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKR 180

Query: 181 DVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDL 240
           DVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDL
Sbjct: 181 DVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDL 240

Query: 241 FLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPT 300
           FLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPT
Sbjct: 241 FLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPT 300

Query: 301 RPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVF 360
           RPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVF
Sbjct: 301 RPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVF 360

Query: 361 KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQ 420
           KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQ
Sbjct: 361 KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQ 420

Query: 421 PGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVW 480
           PGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVW
Sbjct: 421 PGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVW 480

Query: 481 KGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVK 540
           KGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVK
Sbjct: 481 KGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVK 540

Query: 541 EGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCK 600
           EGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCK
Sbjct: 541 EGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCK 600

Query: 601 RSMQEWV 607
           RSMQEWV
Sbjct: 601 RSMQEWV 607


>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
           [Homo sapiens]
          Length = 457

 Score =  872 bits (2253), Expect = 0.0
 Identities = 407/407 (100%), Positives = 407/407 (100%)

Query: 1   MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRM 60
           MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRM
Sbjct: 1   MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRM 60

Query: 61  SVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRY 120
           SVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRY
Sbjct: 61  SVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRY 120

Query: 121 ALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKR 180
           ALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKR
Sbjct: 121 ALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKR 180

Query: 181 DVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDL 240
           DVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDL
Sbjct: 181 DVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDL 240

Query: 241 FLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPT 300
           FLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPT
Sbjct: 241 FLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPT 300

Query: 301 RPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVF 360
           RPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVF
Sbjct: 301 RPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVF 360

Query: 361 KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFK 407
           KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFK
Sbjct: 361 KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFK 407



 Score = 33.9 bits (76), Expect = 0.45
 Identities = 17/51 (33%), Positives = 26/51 (50%), Gaps = 3/51 (5%)

Query: 452 YFFKGDRYWRYSEEMKTMDPGYPKPITV-WKGIPESPQGAFVHKENGFTYF 501
           + FK   +WR     + MD GYP  IT  W+G+P S    + + +  F +F
Sbjct: 358 FVFKDQWFWRVRNN-RVMD-GYPMQITYFWRGLPPSIDAVYENSDGNFVFF 406


>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
          Length = 645

 Score =  856 bits (2212), Expect = 0.0
 Identities = 396/572 (69%), Positives = 468/572 (81%), Gaps = 4/572 (0%)

Query: 38  EQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMK 97
           E  F  + WL+ YGYL P D R S L SA+ +QSA++ MQQFYGI +TG +D+ TI+WMK
Sbjct: 76  EAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMK 135

Query: 98  KPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFD 157
           KPRCGVPD    S +   R KRYALTGQKW+ KHITYSI N TPKVG+ +TRKAIR+AFD
Sbjct: 136 KPRCGVPDHPHLSRRR--RNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFD 193

Query: 158 VWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIG 217
           VWQ VTPLTFEEVPY E+++ +++ DI I FASGFHGDSSPFDGEGGFLAHAYFPGPGIG
Sbjct: 194 VWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIG 253

Query: 218 GDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFK 277
           GDTHFDSDEPWTLGN NHDGNDLFLVAVHELGHALGLEHS+DP+AIMAPFYQYMET NFK
Sbjct: 254 GDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFK 313

Query: 278 LPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTG-RPSYP 336
           LP DDLQGIQKIYGPP +   PTRPLPT+P  R   P++ +   +P+PPRPP G RPS P
Sbjct: 314 LPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTP 373

Query: 337 GAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVY 396
           G KPNICDGNFNT+A+ R EMFVFKD+WFWR+RNNRV +GYPMQI  FW+GLP  IDA Y
Sbjct: 374 GTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAY 433

Query: 397 ENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKG 456
           E +DG FVFFKG+KYWVFK+ T++PGYPH L  LGS +P  GID+A+ WE VGKTYFFKG
Sbjct: 434 ERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKG 493

Query: 457 DRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILK 516
           +RYWRYSEE +  DPGYPKPITVWKGIP++PQGAF+ KE  +TYFYKG++YWKF+NQ L 
Sbjct: 494 ERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLS 553

Query: 517 VEPGYPRSILKDFMGCD-GPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILAL 575
           VEPGYPR+IL+D+MGC+    +R KE   P DDVDI++ +++   +V A+A+VIPCIL+L
Sbjct: 554 VEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNAVAVVIPCILSL 613

Query: 576 CLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 607
           C+LVLVYT+FQFK K  P+ + Y KR +QEWV
Sbjct: 614 CILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV 645


>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
          Length = 669

 Score =  705 bits (1819), Expect = 0.0
 Identities = 342/639 (53%), Positives = 438/639 (68%), Gaps = 56/639 (8%)

Query: 23  LQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGI 82
           L  LL  L   V   +   + E WL+ YGYLP     MS +RSA+ + SALA MQ+FYGI
Sbjct: 33  LLVLLGCLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGI 92

Query: 83  NMTGKVDRNTIDWMKKPRCGVPDQ--TRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVT 140
            +TG +D  T +WMK+PRCGVPDQ   R  +    RRKRYALTG+KW + H+T+SI+N T
Sbjct: 93  PVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYT 152

Query: 141 PKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELE-NGKRDVDITIIFASGFHGDSSPF 199
            K+G   + +A+RRAF VW+  TPL F+EVPY ++    +++ DI ++FASGFHGDSSPF
Sbjct: 153 EKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPF 212

Query: 200 DGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSND 259
           DG GGFLAHAYFPGPG+GGDTHFD+DEPWT  + +  GN+LFLVAVHELGHALGLEHS++
Sbjct: 213 DGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSN 272

Query: 260 PTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRS-----IPP 314
           P AIMAPFYQ+ + DNFKLP DDL+GIQ++YG PD  P PT+PLPTV P R       PP
Sbjct: 273 PNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPP 332

Query: 315 ADPR------KNDRPKPPRPP-----TGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQ 363
             P+      K +RP  P PP     T RP   G  PNICDG+F+T+A+LR EMFVFK +
Sbjct: 333 RPPQPPPPGGKPERPPKPGPPVQPRATERPDQYG--PNICDGDFDTVAMLRGEMFVFKGR 390

Query: 364 WFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGY 423
           WFWRVR+NRV+D YPM I +FWRGLP  I A YE  DG FVFFKG++YW+F++  L+PGY
Sbjct: 391 WFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGY 450

Query: 424 PHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGI 483
           P  L + G GIP   ID+AIWWE  G T+FF+ DRYWR++EE +  DPGYPKPI+VW+GI
Sbjct: 451 PQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGI 510

Query: 484 PESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCD---GPTDRVK 540
           P SP+GAF+  +  +TYFYKG +YWKF+N+ L++EPGYP+SIL+DFMGC     P  R  
Sbjct: 511 PASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGCQEHVEPGPRWP 570

Query: 541 EGHSPP-----------DDVD---------------------IVIKLDNTASTVKAIAIV 568
           +   PP           D  +                     +V++++  A TV  + ++
Sbjct: 571 DVARPPFNPHGGAEPGADSAEGDVGDGDGDFGAGVNKDGGSRVVVQMEEVARTVNVVMVL 630

Query: 569 IPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 607
           +P +L LC+L L Y + Q +RKG PR +LYCKRS+QEWV
Sbjct: 631 VPLLLLLCVLGLTYALVQMQRKGAPRVLLYCKRSLQEWV 669


>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
          Length = 582

 Score =  674 bits (1740), Expect = 0.0
 Identities = 323/586 (55%), Positives = 418/586 (71%), Gaps = 19/586 (3%)

Query: 23  LQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGI 82
           L TL   L +        F+ E WLQ+YGYLPP D R    RS +++ +A+AAMQ+FYG+
Sbjct: 15  LLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGL 74

Query: 83  NMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPK 142
            +TGK D +T+  M++PRCGVPD+     K ++RRKRYA+ G KWQH  IT+ I+N TPK
Sbjct: 75  QVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPK 134

Query: 143 VGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENG-KRDVDITIIFASGFHGDSSPFDG 201
           VG+  T +AIR+AF VW++ TPL F EVPY+ +  G ++  DI I FA GFHGDS+PFDG
Sbjct: 135 VGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDG 194

Query: 202 EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPT 261
           EGGFLAHAYFPGP IGGDTHFDS EPWT+ N + +GND+FLVAVHELGHALGLEHS+DP+
Sbjct: 195 EGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPS 254

Query: 262 AIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKND 321
           AIMAPFYQ+M+T+NF LP+DD +GIQ++YG     P    P P      S+P       D
Sbjct: 255 AIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVP-------D 307

Query: 322 RPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQI 381
           +PK        P+Y    PNICDGNF+T+A+LR EMFVFK++WFWRVRNN+VMDGYPM I
Sbjct: 308 KPK-------NPTYG---PNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPI 357

Query: 382 TYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDS 441
             FWRGLP SI+  YE  DG FVFFKG+K+WVF + +L+PGYP  +  LG G+P   ID+
Sbjct: 358 GQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDA 417

Query: 442 AIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYF 501
           A++W   GKTYFF+G++Y+R++EE++ +D  YPK I VW+GIPESP+G+F+  +  FTYF
Sbjct: 418 ALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYF 477

Query: 502 YKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTAST 561
           YKG +YWKFNNQ LKVEPGYP+S L+D+MGC     R  EG     +V I+   +     
Sbjct: 478 YKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS-GGRPDEGTEEETEVIIIEVDEEGGGA 536

Query: 562 VKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 607
           V A A+V+P +L L +L +   VF F+R GTPR +LYC+RS+ + V
Sbjct: 537 VSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV 582


>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
           sapiens]
          Length = 562

 Score =  370 bits (950), Expect = e-102
 Identities = 202/513 (39%), Positives = 289/513 (56%), Gaps = 39/513 (7%)

Query: 46  WLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPD 105
           WL +YGYLPP  P  + L+S E ++ A+  MQ+F G+  TG++D  T+  M+KPRC +PD
Sbjct: 35  WLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPD 94

Query: 106 QTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNV--TPKVGDPETRKAIRRAFDVWQNVT 163
              G +    RR+RYAL+G  W+ + +T+ +++   + ++     R  +  A   W   +
Sbjct: 95  -VLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGMES 153

Query: 164 PLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPG-IGGDTHF 222
            LTF EV   +     ++ DI I FA  FH DS PFDG GG LAHA+FPG   I GDTHF
Sbjct: 154 GLTFHEVDSPQ----GQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGDTHF 209

Query: 223 DSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQ--YMETDNFKLPN 280
           D +E WT G+ + +G DLF VAVHE GHALGL HS+ P +IM PFYQ    + D ++L  
Sbjct: 210 DDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQ 269

Query: 281 DDLQGIQKIYGPPDKIP--PPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGA 338
           DD  G+Q++YG   + P   PTR  P  PP              P+PP  PT  PS+P  
Sbjct: 270 DDRDGLQQLYGKAPQTPYDKPTRK-PLAPP--------------PQPPASPTHSPSFP-- 312

Query: 339 KPNICDGNFNTLAILRREMFVFKDQWFWRVR-NNRVMDGYPMQITYFWRGLPPSIDAVY- 396
            P+ C+GNF+ +A +R E F FK  WFWR++ + +++   P ++  FW GLP  +  V  
Sbjct: 313 IPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQA 372

Query: 397 ---ENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPP-HGIDSAIWWEDVGKTY 452
               + DG  + F G ++WVF+D  L+ G    L  L  G+PP   +D+   W   GKTY
Sbjct: 373 AYARHRDGRILLFSGPQFWVFQDRQLEGG-ARPLTEL--GLPPGEEVDAVFSWPQNGKTY 429

Query: 453 FFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNN 512
             +G +YWRY E     DPGYP+ +++W+G P SP    V    G TYF+KG  YW+F  
Sbjct: 430 LVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTV-SNAGDTYFFKGAHYWRFPK 488

Query: 513 QILKVEPGYPRSILKDFMGCDGPTDRVKEGHSP 545
             +K EP  P+ +  +++ C  P+   +    P
Sbjct: 489 NSIKTEPDAPQPMGPNWLDCPAPSSGPRAPRPP 521


>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
           sapiens]
          Length = 603

 Score =  358 bits (918), Expect = 1e-98
 Identities = 196/499 (39%), Positives = 274/499 (54%), Gaps = 42/499 (8%)

Query: 46  WLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPD 105
           WL ++GYLPP DP    L++ E +  A+ AMQQF G+  TG +D  T+  MK PRC +PD
Sbjct: 55  WLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPD 114

Query: 106 QTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNV--TPKVGDPETRKAIRRAFDVWQNVT 163
                     RR+R A    KW  +++++ ++       +G    R  +  A  VW ++ 
Sbjct: 115 L---PVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIA 171

Query: 164 PLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPG-PGIGGDTHF 222
           PL F EV  S         DI I F+   H D  PFDG GG +AHA+FPG     GDTHF
Sbjct: 172 PLNFHEVAGSA-------ADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHF 224

Query: 223 DSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETD--NFKLPN 280
           D DE WT  + +  G DLF VAVHE GHA+GL H     +IM P+YQ    D   + LP 
Sbjct: 225 DDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPY 284

Query: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAK- 339
           +D   + ++YG  + + P  +P                  + P  P PP  R S P  K 
Sbjct: 285 EDKVRVWQLYGVRESVSPTAQP-----------------EEPPLLPEPPDNRSSAPPRKD 327

Query: 340 -PNICDGNFNTLAILRREMFVFKDQWFWRV-RNNRVMDGYPMQITYFWRGLP---PSIDA 394
            P+ C  +F+ +A +R E F FK ++FWR+ R+  ++   P Q+  FWRGLP    S+DA
Sbjct: 328 VPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDA 387

Query: 395 VYE-NSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYF 453
           VYE  SD   VFFKG++YWVFKD  ++ GYP  +      +PP GID+A  W    +TYF
Sbjct: 388 VYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDF--SLPPGGIDAAFSWAHNDRTYF 445

Query: 454 FKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQ 513
           FK   YWRY +  + MDPGYP    +W+G+P +   A +   +G +YF++G+EYWK  + 
Sbjct: 446 FKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLDDA-MRWSDGASYFFRGQEYWKVLDG 504

Query: 514 ILKVEPGYPRSILKDFMGC 532
            L+V PGYP+S  +D++ C
Sbjct: 505 ELEVAPGYPQSTARDWLVC 523


>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
          Length = 467

 Score =  311 bits (797), Expect = 1e-84
 Identities = 176/473 (37%), Positives = 248/473 (52%), Gaps = 63/473 (13%)

Query: 43  VEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG 102
           V+ +L+K+  LP    + +       +   L  MQ+F+G+N+TGK +  T+D MKKPRCG
Sbjct: 33  VQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCG 92

Query: 103 VPDQTRGSSKFHIRRKRYALT--GQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQ 160
           VPD              + LT    KW+  ++TY I+N TP++ + E  +AI+ AF++W 
Sbjct: 93  VPDSGG-----------FMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWS 141

Query: 161 NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDT 220
             +PL F  +   E        DI I F    HGD+SPFDG  G LAHA+ PG GIGGD 
Sbjct: 142 VASPLIFTRISQGE-------ADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDA 194

Query: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
           HFD++E WT  + N++   LFLVA HE GH+LGL HS+DP A+M P Y + ET N+ LP 
Sbjct: 195 HFDAEETWTNTSANYN---LFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQ 251

Query: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340
           DD+ GIQ IYG                   S  P  P     PKP  P            
Sbjct: 252 DDIDGIQAIYG------------------LSSNPIQPTGPSTPKPCDPSL---------- 283

Query: 341 NICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSD 400
                 F+ +  LR E+  FKD++FWR R+ ++       I+ FW  LP  I A YE+ D
Sbjct: 284 -----TFDAITTLRGEILFFKDRYFWR-RHPQLQRVEMNFISLFWPSLPTGIQAAYEDFD 337

Query: 401 GNFVF-FKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRY 459
            + +F FKGN+YW      +  GYP D+   G       ID+A+++    KTYFF  D++
Sbjct: 338 RDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYR--SKTYFFVNDQF 395

Query: 460 WRYSEEMKTMDPGYPKPIT-VWKGIPESPQGAFVHKENGFTYFYKGKEYWKFN 511
           WRY  + + M+PGYPK I+  + GI       F  ++  F + + G  Y+ F+
Sbjct: 396 WRYDNQRQFMEPGYPKSISGAFPGIESKVDAVF--QQEHFFHVFSGPRYYAFD 446


>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
          Length = 477

 Score =  307 bits (787), Expect = 2e-83
 Identities = 193/509 (37%), Positives = 266/509 (52%), Gaps = 66/509 (12%)

Query: 26  LLWILCATVC----------GTEQYFN-VEVWLQKYGYLPPTDPRMSVLRSAETMQSALA 74
           +L +LC  VC          G +   N V+ +L+ Y  L     +    + +  +   + 
Sbjct: 6   ILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIR 65

Query: 75  AMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTG-QKWQHKHIT 133
            MQ+F G+ +TGK+D +T++ M+KPRCGVPD        H R       G  KW+  H+T
Sbjct: 66  EMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVG------HFR----TFPGIPKWRKTHLT 115

Query: 134 YSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFH 193
           Y I N TP +       A+ +A  VW+ VTPLTF     S L  G  + DI I FA   H
Sbjct: 116 YRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTF-----SRLYEG--EADIMISFAVREH 168

Query: 194 GDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALG 253
           GD  PFDG G  LAHAY PGPGI GD HFD DE WT    +  G +LFLVA HE+GH+LG
Sbjct: 169 GDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWT---KDTTGTNLFLVAAHEIGHSLG 225

Query: 254 LEHSNDPTAIMAPFYQYM-ETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSI 312
           L HS +  A+M P Y  + +   F+L  DD+ GIQ +YGPP    P +   P VP     
Sbjct: 226 LFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPP----PDSPETPLVPTE--- 278

Query: 313 PPADPRKNDRPKPPRPPTGRPSYPGAKPNICDG--NFNTLAILRREMFVFKDQWFWRVRN 370
                     P PP P T         P  CD   +F+ ++ LR E+ +FKD+ FWR ++
Sbjct: 279 ----------PVPPEPGT---------PANCDPALSFDAVSTLRGEILIFKDRHFWR-KS 318

Query: 371 NRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVF-FKGNKYWVFKDTTLQPGYPHDLIT 429
            R ++     I+ FW  LP  +DA YE +  + VF FKGN++W  +   ++ GYP  + T
Sbjct: 319 LRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHT 378

Query: 430 LGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITV-WKGIPESPQ 488
           LG       ID+AI  ++  KTYFF  D+YWR+ E+  +M+PG+PK I   + GI     
Sbjct: 379 LGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKID 438

Query: 489 GAFVHKENGFTYFYKGKEYWKFNNQILKV 517
             F  +E GF YF+ G    +F+    KV
Sbjct: 439 AVF--EEFGFFYFFTGSSQLEFDPNAKKV 465


>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
          Length = 471

 Score =  303 bits (777), Expect = 2e-82
 Identities = 184/483 (38%), Positives = 252/483 (52%), Gaps = 65/483 (13%)

Query: 44  EVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGV 103
           E +L+ Y Y P     +    +A +M   L  MQ F+G+ +TGK+D NT+D MKKPRCGV
Sbjct: 40  ERYLRSY-YHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGV 98

Query: 104 PDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVT 163
           PD      ++++  +       KW   ++TY I N TP +   E  KA ++AF VW +VT
Sbjct: 99  PDV----GEYNVFPRTL-----KWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVT 149

Query: 164 PLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFD 223
           PL F     + L +G    DI I F    HGD  PFDG  G LAHA+ PGP  GGD HFD
Sbjct: 150 PLNF-----TRLHDGI--ADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFD 202

Query: 224 SDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDL 283
            DE WT  +    G +LFLVA HE GH+LGL+HS DP A+M P Y Y    +F LP+DD+
Sbjct: 203 DDETWTSSSK---GYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDV 259

Query: 284 QGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNIC 343
           QGIQ +YGP D+ P P  P                                     P+ C
Sbjct: 260 QGIQSLYGPGDEDPNPKHP-----------------------------------KTPDKC 284

Query: 344 DGNFNTLAI--LRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDG 401
           D + +  AI  LR E  +FKD++FWR+   +V D        FW  LP  IDA YE+   
Sbjct: 285 DPSLSLDAITSLRGETMIFKDRFFWRLHPQQV-DAELFLTKSFWPELPNRIDAAYEHPSH 343

Query: 402 NFVF-FKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYW 460
           + +F F+G K+W      +  GYP  +  LG       I +A+ +ED GKT  F G++ W
Sbjct: 344 DLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVW 403

Query: 461 RYSEEMKTMDPGYPKPITV-WKGIPESPQGAFVHKENGFTYFYKGK---EYWKFNNQILK 516
           RY +    MD  YP+ I   + GI +      V+++NG+ YF+ G    EY  ++N+I++
Sbjct: 404 RYDDTNHIMDKDYPRLIEEDFPGIGDKVDA--VYEKNGYIYFFNGPIQFEYSIWSNRIVR 461

Query: 517 VEP 519
           V P
Sbjct: 462 VMP 464


>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
           sapiens]
          Length = 470

 Score =  300 bits (767), Expect = 3e-81
 Identities = 176/473 (37%), Positives = 255/473 (53%), Gaps = 59/473 (12%)

Query: 44  EVWLQK-YGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG 102
           E +L+K YG      P   +  S   M+  +  MQ F G+ +TG++D +T++ M  PRCG
Sbjct: 34  ERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCG 93

Query: 103 VPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNV 162
           VPD         +   R    G  W+  +ITY I N TP +   +   AIR+AF VW NV
Sbjct: 94  VPD---------VHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNV 144

Query: 163 TPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHF 222
           TPL F     S++  G    DI ++FA G HGD   FDG+GG LAHA+ PG GIGGD HF
Sbjct: 145 TPLKF-----SKINTGM--ADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHF 197

Query: 223 DSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDD 282
           D DE WT    +  G +LFL AVHE+GH+LGL HS+DP A+M P Y+Y++ + F+L  DD
Sbjct: 198 DEDEFWTT---HSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADD 254

Query: 283 LQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNI 342
           ++GIQ +YG                        DP++N R          P+   ++P +
Sbjct: 255 IRGIQSLYG------------------------DPKENQR---------LPNPDNSEPAL 281

Query: 343 CDGN--FNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSD 400
           CD N  F+ +  +  ++F FKD++FW   + R      + I+  W  LP  I+A YE   
Sbjct: 282 CDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNL-ISSLWPTLPSGIEAAYEIEA 340

Query: 401 GNFVF-FKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRY 459
            N VF FK +KYW+  +   +P YP  + + G       ID+A++     +TYFF  ++Y
Sbjct: 341 RNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQY 400

Query: 460 WRYSEEMKTMDPGYPKPITV-WKGIPESPQGAFVHKENGFTYFYKGKEYWKFN 511
           WRY E  + MDPGYPK IT  ++GI       F + +N + YF++G   ++++
Sbjct: 401 WRYDERRQMMDPGYPKLITKNFQGIGPKIDAVF-YSKNKYYYFFQGSNQFEYD 452


>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
           sapiens]
          Length = 488

 Score =  295 bits (754), Expect = 1e-79
 Identities = 163/443 (36%), Positives = 235/443 (53%), Gaps = 33/443 (7%)

Query: 96  MKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRA 155
           ++ PRCGVPD + G S  + R+KR+ L+G +W+   +TY I     ++   + R+ +  A
Sbjct: 75  LRPPRCGVPDPSDGLSARN-RQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEA 133

Query: 156 FDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPG 215
             VW +VTPLTF EV       G+   DI I FA  +HGD  PFDG GG LAHA+FP   
Sbjct: 134 LKVWSDVTPLTFTEV-----HEGR--ADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTH 186

Query: 216 IGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDN 275
             GD HFD DE WT+G+    G DL  VA HE GH LGL+H+    A+M+ FY +     
Sbjct: 187 REGDVHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP-- 242

Query: 276 FKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSY 335
             L  DD +G+Q +YG P   P  T   P + P   I   +                P  
Sbjct: 243 LSLSPDDCRGVQHLYGQP--WPTVTSRTPALGPQAGIDTNEIA--------------PLE 286

Query: 336 PGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAV 395
           P A P+ C+ +F+ ++ +R E+F FK  + WR+R  ++  GYP   +  W+GLP  +DA 
Sbjct: 287 PDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAA 346

Query: 396 YENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLG-SGIPPHGIDSAIWWEDVGKTYFF 454
           +E++ G+  FF+G +YWV+       G P  L  LG    P H   + +W  +  K YFF
Sbjct: 347 FEDAQGHIWFFQGAQYWVYDGEKPVLG-PAPLTELGLVRFPVHA--ALVWGPEKNKIYFF 403

Query: 455 KGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQI 514
           +G  YWR+    + +D   P+  T W+G+P     AF    +G+ YF +G+ YWKF+   
Sbjct: 404 RGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAF-QDADGYAYFLRGRLYWKFDPVK 462

Query: 515 LKVEPGYPRSILKDFMGCDGPTD 537
           +K   G+PR +  DF GC  P +
Sbjct: 463 VKALEGFPRLVGPDFFGCAEPAN 485


>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
           sapiens]
          Length = 469

 Score =  290 bits (742), Expect = 3e-78
 Identities = 180/483 (37%), Positives = 253/483 (52%), Gaps = 70/483 (14%)

Query: 43  VEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG 102
           V+ +L+KY  L     ++   R++  +   L  MQ+F+G+ +TGK D  T+  MK+PRCG
Sbjct: 34  VQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCG 93

Query: 103 VPDQTRGSSKFHIRRKRYALT--GQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQ 160
           VPD  +           + LT    +W+  H+TY I+N TP +   +   AI +AF +W 
Sbjct: 94  VPDVAQ-----------FVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWS 142

Query: 161 NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDT 220
           NVTPLTF +V   +        DI I F  G H D+SPFDG GG LAHA+ PGPGIGGD 
Sbjct: 143 NVTPLTFTKVSEGQ-------ADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDA 195

Query: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
           HFD DE WT    N    +L  VA HELGH+LGL HS D  A+M P Y +  + + +L  
Sbjct: 196 HFDEDERWT---NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF--SGDVQLAQ 250

Query: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340
           DD+ GIQ IYG                          R  +  +P  P T         P
Sbjct: 251 DDIDGIQAIYG--------------------------RSQNPVQPIGPQT---------P 275

Query: 341 NICDG--NFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQ-ITYFWRGLPPSIDAVYE 397
             CD    F+ +  +R E+  FKD+++  +R N       +  I+ FW  LP  ++A YE
Sbjct: 276 KACDSKLTFDAITTIRGEVMFFKDRFY--MRTNPFYPEVELNFISVFWPQLPNGLEAAYE 333

Query: 398 NSDGNFV-FFKGNKYWVFKDTTLQPGYPHDLI-TLGSGIPPHGIDSAIWWEDVGKTYFFK 455
            +D + V FFKGNKYW  +   +  GYP D+  + G       ID+A+  E+ GKTYFF 
Sbjct: 334 FADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFV 393

Query: 456 GDRYWRYSEEMKTMDPGYPKPIT-VWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQI 514
            ++YWRY E  ++MDPGYPK I   + GI       F+  ++GF YF+ G   +KF+ + 
Sbjct: 394 ANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFM--KDGFFYFFHGTRQYKFDPKT 451

Query: 515 LKV 517
            ++
Sbjct: 452 KRI 454


>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
          Length = 476

 Score =  285 bits (729), Expect = 9e-77
 Identities = 186/502 (37%), Positives = 261/502 (51%), Gaps = 67/502 (13%)

Query: 27  LWILCATVCGT--------EQYFNVEV---WLQKYGYLPPTDPRMSVLRSAETMQSALAA 75
           L +LC  VC          E+  N ++   +L+KY Y    D +    + +  +   +  
Sbjct: 7   LVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKY-YNLEKDVKQFRRKDSNLIVKKIQG 65

Query: 76  MQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQ-KWQHKHITY 134
           MQ+F G+ +TGK+D +T++ M+KPRCGVPD    SS            G  KW+  H+TY
Sbjct: 66  MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSS----------FPGMPKWRKTHLTY 115

Query: 135 SIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHG 194
            I N TP +       AI +A  VW+ VTPLTF     S L  G  + DI I FA   HG
Sbjct: 116 RIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTF-----SRLYEG--EADIMISFAVKEHG 168

Query: 195 DSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGL 254
           D   FDG G  LAHAY PGPG+ GD HFD DE WT    +  G +LFLVA HELGH+LGL
Sbjct: 169 DFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWT---EDASGTNLFLVAAHELGHSLGL 225

Query: 255 EHSNDPTAIMAPFYQ-YMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIP 313
            HS +  A+M P Y  + E   F+L  DD+ GIQ +YGPP    P +   P VP  +S+P
Sbjct: 226 FHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPP----PASTEEPLVPT-KSVP 280

Query: 314 PADPRKNDRPKPPRPPTGRPSYPGAKPNICDG--NFNTLAILRREMFVFKDQWFWRVRNN 371
                                     P  CD   +F+ ++ LR E   FKD++FWR  + 
Sbjct: 281 SGSEM---------------------PAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHW 319

Query: 372 RVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVF-FKGNKYWVFKDTTLQPGYPHDLITL 430
                + + I+ FW  LP  +DA YE +  + VF FKGN++W  +   +Q GYP  + TL
Sbjct: 320 NPEPEFHL-ISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTL 378

Query: 431 GSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPIT-VWKGIPESPQG 489
           G       ID+A+  ++  KTYFF  D+YWR+ E  ++M+ G+P+ I   + G+   P+ 
Sbjct: 379 GFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGV--EPKV 436

Query: 490 AFVHKENGFTYFYKGKEYWKFN 511
             V +  GF YF+ G   ++F+
Sbjct: 437 DAVLQAFGFFYFFSGSSQFEFD 458


>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
          Length = 403

 Score =  283 bits (724), Expect = 3e-76
 Identities = 173/450 (38%), Positives = 238/450 (52%), Gaps = 70/450 (15%)

Query: 76  MQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALT--GQKWQHKHIT 133
           MQ+F+G+ +TGK D  T+  MK+PRCGVPD  +           + LT    +W+  H+T
Sbjct: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQ-----------FVLTEGNPRWEQTHLT 49

Query: 134 YSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFH 193
           Y I+N TP +   +   AI +AF +W NVTPLTF +V   +        DI I F  G H
Sbjct: 50  YRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQ-------ADIMISFVRGDH 102

Query: 194 GDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALG 253
            D+SPFDG GG LAHA+ PGPGIGGD HFD DE WT    N    +L  VA HELGH+LG
Sbjct: 103 RDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT---NNFREYNLHRVAAHELGHSLG 159

Query: 254 LEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIP 313
           L HS D  A+M P Y +  + + +L  DD+ GIQ IYG                      
Sbjct: 160 LSHSTDIGALMYPSYTF--SGDVQLAQDDIDGIQAIYG---------------------- 195

Query: 314 PADPRKNDRPKPPRPPTGRPSYPGAKPNICDG--NFNTLAILRREMFVFKDQWFWRVRNN 371
               R  +  +P  P T         P  CD    F+ +  +R E+  FKD+++  +R N
Sbjct: 196 ----RSQNPVQPIGPQT---------PKACDSKLTFDAITTIRGEVMFFKDRFY--MRTN 240

Query: 372 RVMDGYPMQ-ITYFWRGLPPSIDAVYENSDGNFV-FFKGNKYWVFKDTTLQPGYPHDLI- 428
                  +  I+ FW  LP  ++A YE +D + V FFKGNKYW  +   +  GYP D+  
Sbjct: 241 PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYS 300

Query: 429 TLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPIT-VWKGIPESP 487
           + G       ID+A+  E+ GKTYFF  ++YWRY E  ++MDPGYPK I   + GI    
Sbjct: 301 SFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV 360

Query: 488 QGAFVHKENGFTYFYKGKEYWKFNNQILKV 517
              F+  ++GF YF+ G   +KF+ +  ++
Sbjct: 361 DAVFM--KDGFFYFFHGTRQYKFDPKTKRI 388


>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
           sapiens]
          Length = 483

 Score =  275 bits (704), Expect = 7e-74
 Identities = 165/458 (36%), Positives = 237/458 (51%), Gaps = 57/458 (12%)

Query: 62  VLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYA 121
           V R + +M   +  +Q F+G+ +TGK+D+ T++ +KKPRCGVPD         +   R  
Sbjct: 61  VARGSNSMIRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPD---------VANYRLF 111

Query: 122 LTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRD 181
               KW+   +TY I   TP +   E  KA+  A   W +  PL+F  +   E       
Sbjct: 112 PGEPKWKKNTLTYRISKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGE------- 164

Query: 182 VDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLF 241
            DI I F +G HGDS PFDG  G LAHA+ PG G+GGDTHFD+ E WT+G    +G +LF
Sbjct: 165 ADIMISFENGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT---NGFNLF 221

Query: 242 LVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTR 301
            VA HE GHALGL HS DP+A+M P Y+Y     F LP DD++GIQ +YG          
Sbjct: 222 TVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQALYG---------- 271

Query: 302 PLPTVPPHRSIPPADPRKNDRPKP--PRPPTGRPSYPGAKPNICD--GNFNTLAILRREM 357
                          PRK    KP  P  P  +PS     P++CD   +F+ + +L +E+
Sbjct: 272 ---------------PRKVFLGKPTLPHAPHHKPSI----PDLCDSSSSFDAVTMLGKEL 312

Query: 358 FVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSD-GNFVFFKGNKYWVFKD 416
            +FKD+ FWR + +      P  IT  +  L  ++DA YE ++ G   FFKG  YW+ + 
Sbjct: 313 LLFKDRIFWRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRG 372

Query: 417 TTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKP 476
             +Q G P  +   G       ID+A++  +  KT FF GD Y+ Y E  + M+  YPK 
Sbjct: 373 FQMQ-GPPRTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKRKMEKDYPKN 431

Query: 477 I-TVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQ 513
               + G+      A   + NG+ YF+ G + +K++ +
Sbjct: 432 TEEEFSGVNGQIDAAV--ELNGYIYFFSGPKTYKYDTE 467


>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
          Length = 513

 Score =  259 bits (661), Expect = 7e-69
 Identities = 160/452 (35%), Positives = 224/452 (49%), Gaps = 62/452 (13%)

Query: 64  RSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALT 123
           ++   +   +  MQ F+G+ +TGK+D NT++ MK PRCGVPD         + +  Y L 
Sbjct: 54  KNRSLIDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPD---------VGQYGYTLP 104

Query: 124 GQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVD 183
           G  W+  ++TY I N TP +      +AI+   +VW  VTPL F ++        K   D
Sbjct: 105 G--WRKYNLTYRIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKI-------SKGIAD 155

Query: 184 ITIIFASGFHGDSSP-FDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFL 242
           I I F +  HG     FDG  G L HA+ PGPG+GGDTHFD DE WT       G +LFL
Sbjct: 156 IMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHFDEDENWTKDGA---GFNLFL 212

Query: 243 VAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRP 302
           VA HE GHALGL HSND TA+M P Y  ++   + L  DD+ GIQ IYG   K       
Sbjct: 213 VAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQDDINGIQSIYGGLPK------- 265

Query: 303 LPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGN--FNTLAILRREMFVF 360
                               P  P+ PT         P+ CD +  F+ +   RRE+  F
Sbjct: 266 -------------------EPAKPKEPT--------IPHACDPDLTFDAITTFRREVMFF 298

Query: 361 KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQ 420
           K +  WR+  + + D     I  FW  LP  + A YEN     + FK   +W+ +   + 
Sbjct: 299 KGRHLWRIYYD-ITDVEFELIASFWPSLPADLQAAYENPRDKILVFKDENFWMIRGYAVL 357

Query: 421 PGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITV- 479
           P YP  + TLG       ID+A+  +   KTYFF G   WR+ E  +TMD G+P+ +   
Sbjct: 358 PDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKH 417

Query: 480 WKGIPESPQGAFVHKENGFTYFYKGKEYWKFN 511
           + GI      AF +K  GF +F +G + ++++
Sbjct: 418 FPGISIRVDAAFQYK--GFFFFSRGSKQFEYD 447


>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
           [Homo sapiens]
          Length = 508

 Score =  252 bits (643), Expect = 8e-67
 Identities = 179/528 (33%), Positives = 268/528 (50%), Gaps = 65/528 (12%)

Query: 46  WLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPD 105
           +L +YGYL       +  +  E +  AL A Q+   + ++G++D  T   M++PRCG+ D
Sbjct: 31  YLSQYGYLQKPLEGSNNFKP-EDITEALRAFQEASELPVSGQLDDATRARMRQPRCGLED 89

Query: 106 QTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPL 165
                  F+ +  +Y L G +W+ KH+T+ I N+   +     R A+R+AF  W NV PL
Sbjct: 90  P------FNQKTLKYLLLG-RWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPL 142

Query: 166 TFEEVPYSELENGKRDVDITIIFASGFHGD-----SSPFDGEGGFLAHAYFPGPGIGGDT 220
           TF+EV     + G  D+ ++      FHG      S+ FDG G  LAHA  P     G  
Sbjct: 143 TFQEV-----QAGAADIRLS------FHGRQSSYCSNTFDGPGRVLAHADIPEL---GSV 188

Query: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
           HFD DE WT G   + G +L ++A HE+GHALGL HS    A+MAP Y+     +FKL  
Sbjct: 189 HFDEDEFWTEG--TYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYR-PHFKLHP 245

Query: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340
           DD+ GIQ +YG   K  P  R              D  + +   P  PP   P+ P   P
Sbjct: 246 DDVAGIQALYG---KKSPVIR--------------DEEEEETELPTVPPV--PTEPSPMP 286

Query: 341 NICDGNFNTLAI-LRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSID-AVYEN 398
           + C    + + +  R + + FK  + W V ++    G   +++  W GLP ++D AVY  
Sbjct: 287 DPCSSELDAMMLGPRGKTYAFKGDYVWTVSDSG--PGPLFRVSALWEGLPGNLDAAVYSP 344

Query: 399 SDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDR 458
                 FFKG+K W + +  + PG+P  L    + + P+ +D+A++W    K + FKG  
Sbjct: 345 RTQWIHFFKGDKVWRYINFKMSPGFPKKL----NRVEPN-LDAALYWPLNQKVFLFKGSG 399

Query: 459 YWRYSEEMKTMDPGYPKPIT-VWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKV 517
           YW++ E  +T    YPKPI  ++ G+P  P  A +  ++G  YF+KGK YW+ N Q L+V
Sbjct: 400 YWQWDELARTDFSSYPKPIKGLFTGVPNQPSAA-MSWQDGRVYFFKGKVYWRLNQQ-LRV 457

Query: 518 EPGYPRSILKDFMGCDGPT--DRVKEGHSPPDDVDIVIKLDNTASTVK 563
           E GYPR+I  ++M C   T       G++ P    I   LD T S  +
Sbjct: 458 EKGYPRNISHNWMHCRPRTIDTTPSGGNTTPSGTGIT--LDTTLSATE 503


>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 520

 Score =  244 bits (622), Expect = 2e-64
 Identities = 170/533 (31%), Positives = 257/533 (48%), Gaps = 57/533 (10%)

Query: 23  LQTLLW----ILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQ 78
           LQ LLW       A   G E     E +L+KYGYL    P+     ++     A+ A Q 
Sbjct: 12  LQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAP---TSTRFSDAIRAFQW 68

Query: 79  FYGINMTGKVDRNTIDWMKKPRCGVPDQT--------------RGSSKFHIRRKRYALTG 124
              + ++G +DR T+  M +PRCGV D                R  +K   R+KR+A  G
Sbjct: 69  VSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMR-RKKRFAKQG 127

Query: 125 QKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDI 184
            KW  +H++Y + N    + +P  R A+R AF +W NV+ L F E P           DI
Sbjct: 128 NKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAP------ATGPADI 181

Query: 185 TIIFASGFHGD--SSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFL 242
            + F  G H D   + FDG GG LAHA+ P     G+ HFD DE W+L      G +LF+
Sbjct: 182 RLTFFQGDHNDGLGNAFDGPGGALAHAFLPR---RGEAHFDQDERWSLS--RRRGRNLFV 236

Query: 243 VAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRP 302
           V  HE+GH LGL HS  P A+MAP+Y+ +  D   L  DD+  +Q +YG      P    
Sbjct: 237 VLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDAL-LSWDDVLAVQSLYG-----KPLGGS 290

Query: 303 LPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILR-REMFVFK 361
           +    P +     +   +  P+  RP T  P Y       C  +F+ + + R +++++FK
Sbjct: 291 VAVQLPGKLFTDFETWDSYSPQGRRPETQGPKY-------CHSSFDAITVDRQQQLYIFK 343

Query: 362 DQWFWRV-RNNRVMDGYPMQITYFWRGLPPSIDAVYEN-SDGNFVFFKGNKYWVFKDTTL 419
              FW V  +  V +  P+Q    W GLPP+I+A   + +DG+F FFKG + W F+    
Sbjct: 344 GSHFWEVAADGNVSEPRPLQER--WVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKP 401

Query: 420 QPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITV 479
             G P   +    G+P H  D+A+++  + +   FKG RY+  +     ++P YP+ +  
Sbjct: 402 VWGLPQ--LCRAGGLPRHP-DAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQD 458

Query: 480 WKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGC 532
           W GIPE   GA + + +G   F++   YW+ +   L+       +    +MGC
Sbjct: 459 WGGIPEEVSGA-LPRPDGSIIFFRDDRYWRLDQAKLQATTSGRWATELPWMGC 510


>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
          Length = 610

 Score =  216 bits (550), Expect = 5e-56
 Identities = 128/317 (40%), Positives = 167/317 (52%), Gaps = 41/317 (12%)

Query: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
           ++D D  W  G     G  LFLVA HE GHA+GLEHS DP A+MAP Y Y  T NF+L  
Sbjct: 330 NYDDDRKW--GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQ 385

Query: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340
           DD++GIQ++YG    I   T P PT+ P                               P
Sbjct: 386 DDIKGIQELYGASPDIDLGTGPTPTLGP-----------------------------VTP 416

Query: 341 NIC--DGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYEN 398
            IC  D  F+ +A +R E+F FKD++ WR    R     P+ +  FW  LP  IDAVYE 
Sbjct: 417 EICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEA 476

Query: 399 -SDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGD 457
             +   VFF GN+YW++  +TL+ GYP  L +LG       +D+A  W    KTY F GD
Sbjct: 477 PQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGD 536

Query: 458 RYWRYSEEMKTMDPGYPKPIT-VWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILK 516
           ++WRY+E  K MDPG+PK I   W  IP++       +  G +YF+KG  Y K  NQ LK
Sbjct: 537 KFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLK 596

Query: 517 -VEPGYPRSILKDFMGC 532
            V+ G   SI  D++GC
Sbjct: 597 SVKFG---SIKSDWLGC 610



 Score =  137 bits (344), Expect = 4e-32
 Identities = 77/164 (46%), Positives = 97/164 (59%), Gaps = 18/164 (10%)

Query: 69  MQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQ 128
           ++  L  MQ+F+G+  TG +D+NTI+ M+KPRCG PD    +  F  R+        KW 
Sbjct: 20  LKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVA--NYNFFPRKP-------KWD 70

Query: 129 HKHITYSIKNVTPKVGDPET-RKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITII 187
              ITY I   TP + DPET   A  RAF VW +VTPL F     S + +G  + DI I 
Sbjct: 71  KNQITYRIIGYTPDL-DPETVDDAFARAFQVWSDVTPLRF-----SRIHDG--EADIMIN 122

Query: 188 FASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLG 231
           F    HGD  PFDG+ G LAHA+ PG G+GGD+HFD DE WTLG
Sbjct: 123 FGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLG 166


>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
           [Homo sapiens]
          Length = 660

 Score =  216 bits (550), Expect = 5e-56
 Identities = 128/317 (40%), Positives = 167/317 (52%), Gaps = 41/317 (12%)

Query: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
           ++D D  W  G     G  LFLVA HE GHA+GLEHS DP A+MAP Y Y  T NF+L  
Sbjct: 380 NYDDDRKW--GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQ 435

Query: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340
           DD++GIQ++YG    I   T P PT+ P                               P
Sbjct: 436 DDIKGIQELYGASPDIDLGTGPTPTLGP-----------------------------VTP 466

Query: 341 NIC--DGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYEN 398
            IC  D  F+ +A +R E+F FKD++ WR    R     P+ +  FW  LP  IDAVYE 
Sbjct: 467 EICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEA 526

Query: 399 -SDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGD 457
             +   VFF GN+YW++  +TL+ GYP  L +LG       +D+A  W    KTY F GD
Sbjct: 527 PQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGD 586

Query: 458 RYWRYSEEMKTMDPGYPKPIT-VWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILK 516
           ++WRY+E  K MDPG+PK I   W  IP++       +  G +YF+KG  Y K  NQ LK
Sbjct: 587 KFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLK 646

Query: 517 -VEPGYPRSILKDFMGC 532
            V+ G   SI  D++GC
Sbjct: 647 SVKFG---SIKSDWLGC 660



 Score =  137 bits (344), Expect = 4e-32
 Identities = 77/164 (46%), Positives = 97/164 (59%), Gaps = 18/164 (10%)

Query: 69  MQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQ 128
           ++  L  MQ+F+G+  TG +D+NTI+ M+KPRCG PD    +  F  R+        KW 
Sbjct: 70  LKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVA--NYNFFPRKP-------KWD 120

Query: 129 HKHITYSIKNVTPKVGDPET-RKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITII 187
              ITY I   TP + DPET   A  RAF VW +VTPL F     S + +G  + DI I 
Sbjct: 121 KNQITYRIIGYTPDL-DPETVDDAFARAFQVWSDVTPLRF-----SRIHDG--EADIMIN 172

Query: 188 FASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLG 231
           F    HGD  PFDG+ G LAHA+ PG G+GGD+HFD DE WTLG
Sbjct: 173 FGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLG 216


>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
          Length = 267

 Score =  180 bits (457), Expect = 3e-45
 Identities = 100/248 (40%), Positives = 137/248 (55%), Gaps = 22/248 (8%)

Query: 46  WLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPD 105
           W Q   YL       S  ++A ++++ L  MQ+F+G+ +TG ++   I+ M+KPRCGVPD
Sbjct: 32  WEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPD 91

Query: 106 QTRGSSKFHIRRKRYAL--TGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVT 163
                         Y+L     KW  K +TY I + T  +      + + +A ++W    
Sbjct: 92  VAE-----------YSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEI 140

Query: 164 PLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFD 223
           PL F +V +          DI I FA G HGDS PFDG G  LAHA+ PG G+GGD HFD
Sbjct: 141 PLHFRKVVWGT-------ADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFD 193

Query: 224 SDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDL 283
            DE WT G+    G +    A HELGH+LG+ HS+DP A+M P Y   +  NFKL  DD+
Sbjct: 194 EDERWTDGSSL--GINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDI 251

Query: 284 QGIQKIYG 291
           +GIQK+YG
Sbjct: 252 KGIQKLYG 259


>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
           sapiens]
          Length = 261

 Score =  142 bits (359), Expect = 7e-34
 Identities = 86/224 (38%), Positives = 117/224 (52%), Gaps = 20/224 (8%)

Query: 68  TMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKW 127
           T ++    +QQF+  N T  +D      + +P CGVPD     S   I   R      KW
Sbjct: 50  TQETQTQLLQQFHR-NGTDLLDMQMHALLHQPHCGVPD----GSDTSISPGRC-----KW 99

Query: 128 QHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITII 187
               +TY I N    +     + +I  A  +W NVTPL F++V     +NG  D DI + 
Sbjct: 100 NKHTLTYRIINYPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQV-----QNG--DADIKVS 152

Query: 188 FASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHE 247
           F    H D  PFDG GG L HA+ P  G  G  HFD +E W+  +    G +LFLVA HE
Sbjct: 153 FWQWAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFDKNEHWSASDT---GYNLFLVATHE 209

Query: 248 LGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYG 291
           +GH+LGL+HS + ++IM P Y Y +   F+L  DD+Q IQ +YG
Sbjct: 210 IGHSLGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQRIQHLYG 253


>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
          Length = 707

 Score =  140 bits (353), Expect = 3e-33
 Identities = 102/319 (31%), Positives = 152/319 (47%), Gaps = 35/319 (10%)

Query: 220 THFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLP 279
           ++FDSD+ W  G     G  LFLVA HE GHALGL+HS+ P A+M P Y++  T+   L 
Sbjct: 377 SNFDSDKKW--GFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRF--TEGPPLH 432

Query: 280 NDDLQGIQKIYGP---PDKIPP-PTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSY 335
            DD+ GI+ +YGP   P+  PP  T P PT PP    P   P  +   +P   PTG PS 
Sbjct: 433 KDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPP-TVCPTGPPTVHPSERPTAGPTGPPSA 491

Query: 336 -----PGAKP------------NICDGN-FNTLAILRREMFVFKDQWFWRVRNNR-VMDG 376
                P A P            + C+ N F+ +A +  ++++FKD  +WR    R     
Sbjct: 492 GPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQ 551

Query: 377 YPMQITYFWRGLPPSIDAVYENS-DGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIP 435
            P  I   W  LP  +D+V+E        FF G + WV+   ++    P  L  LG G  
Sbjct: 552 GPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLG--PRRLDKLGLGAD 609

Query: 436 PHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPI-TVWKGIPESPQGAFVHK 494
              +  A+     GK   F G R WR+  + + +DP     +  ++ G+P      F ++
Sbjct: 610 VAQVTGAL-RSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQYR 668

Query: 495 ENGFTYFYKGKEYWKFNNQ 513
           E    YF + + YW+ +++
Sbjct: 669 EK--AYFCQDRFYWRVSSR 685



 Score =  129 bits (323), Expect = 1e-29
 Identities = 81/200 (40%), Positives = 104/200 (52%), Gaps = 26/200 (13%)

Query: 44  EVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGV 103
           E +L +YGY    + R      ++++  AL  +Q+   +  TG++D  T+  M+ PRCGV
Sbjct: 46  EEYLYRYGYTRVAEMR----GESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGV 101

Query: 104 PDQTRGSSKFHIRRKRYALTGQ-KWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNV 162
           PD  R  +            G  KW H +ITY I+N +  +       A  RAF +W  V
Sbjct: 102 PDLGRFQT----------FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAV 151

Query: 163 TPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHF 222
           TPLTF  V YS      RD DI I F    HGD  PFDG+ G LAHA+ PGPGI GD HF
Sbjct: 152 TPLTFTRV-YS------RDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHF 204

Query: 223 DSDEPWTLGN----PNHDGN 238
           D DE W+LG     P   GN
Sbjct: 205 DDDELWSLGKGVVVPTRFGN 224


>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
           sapiens]
          Length = 569

 Score =  130 bits (326), Expect = 5e-30
 Identities = 143/526 (27%), Positives = 211/526 (40%), Gaps = 137/526 (26%)

Query: 54  PPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQT------ 107
           PP  P+ + L  A      +   Q+   +  +G++D  T+  M +PRCGVPD        
Sbjct: 76  PPETPKGAALAEA------VRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSA 129

Query: 108 ---------RGSSKFHIRRKRYALTGQKWQ--------------HKHITYSI--KNVTPK 142
                    R  S+    R   +L+ + WQ               + +++ +  + ++ +
Sbjct: 130 PPSPPGPPPRARSR-RSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQ 188

Query: 143 VGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFH-GDSSPFDG 201
           +   + R+ +  AF +W  VTPL F E    +L      VDI + F  G H G    FDG
Sbjct: 189 LSVADQRRIVALAFRMWSEVTPLDFRE----DLAAPGAAVDIKLGFGRGRHLGCPRAFDG 244

Query: 202 EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHD-GNDLFLVAVHELGHALGLEHSNDP 260
            G   AHA+  G     D HFD DE +T   P  D G  L  VAVHE+GH LGL H+   
Sbjct: 245 SGQEFAHAWRLG-----DIHFDDDEHFT--PPTSDTGISLLKVAVHEIGHVLGLPHTYRT 297

Query: 261 TAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKN 320
            +IM P Y   E   F+L   D + IQK+YG                             
Sbjct: 298 GSIMQPNYIPQE-PAFELDWSDRKAIQKLYGS---------------------------- 328

Query: 321 DRPKPPRPPTGRPSYPGAKPNICDGNFNTL-------------AILRREMFVFKDQWFW- 366
                                 C+G+F+T               ++R   + F++ W+W 
Sbjct: 329 ----------------------CEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWL 366

Query: 367 -RVRNNRVMDGYPMQITYFWRGLPP-SIDA---VYENSDGNFVFFKGNKYWVF---KDTT 418
              RNNR   G P+QI   W G+P  +IDA   ++        FF+GN+YW +   KD  
Sbjct: 367 YENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQA 426

Query: 419 LQ-----PGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGY 473
           L        YP  LI+ G    P  +D+A +       YFFK    + +      +   Y
Sbjct: 427 LTEDEQGKSYP-KLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSY 485

Query: 474 PKPIT-VWKG-IPESP-----QGAFVHKENGFTYFYKGKEYWKFNN 512
           PK IT V+   IP++        A+        +F+KG  YWK  N
Sbjct: 486 PKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVN 531



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 43/136 (31%), Positives = 68/136 (50%), Gaps = 11/136 (8%)

Query: 405 FFKGNKYWVFKDTTLQPGY--PHDLITLGSGIPPHGIDSA--IWWEDVGKTYFFKGDRYW 460
           FF+ + YW++++   +  Y  P  ++T   GIP H ID+   IW     + YFF+G++YW
Sbjct: 358 FFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYW 417

Query: 461 RYS---EEMKTMDP---GYPKPITV-WKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQ 513
           RY    ++  T D     YPK I+  + GIP     AF  +     YF+K    + F+  
Sbjct: 418 RYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVN 477

Query: 514 ILKVEPGYPRSILKDF 529
             +V   YP+ I + F
Sbjct: 478 RNRVLNSYPKRITEVF 493


>gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]
          Length = 390

 Score =  101 bits (251), Expect = 2e-21
 Identities = 72/194 (37%), Positives = 99/194 (51%), Gaps = 22/194 (11%)

Query: 116 RRKRYALTGQK--WQHKHITYSIKNVTPKVGDP-ETRKAIRRAFDVWQNVTPLTFEEVPY 172
           RR+RY LT  +  W H ++TY I +    +  P ETR+A+  AF +W +V+P +F EV  
Sbjct: 75  RRRRYTLTPARLRWDHFNLTYRILSFPRNLLSPRETRRALAAAFRMWSDVSPFSFREVAP 134

Query: 173 ---SELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWT 229
              S+L  G   ++ T    S  H     FDG  G LAHA+FP  G     HFD  E W 
Sbjct: 135 EQPSDLRIGFYPINHTDCLVSALH---HCFDGPTGELAHAFFPPHG---GIHFDDSEYWV 188

Query: 230 LGNPNHDGN------DLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFK-LPNDD 282
           LG   +         DL  VA HE+GHALGL HS    A+M   +       +K L  D+
Sbjct: 189 LGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALM---HLNATLRGWKALSQDE 245

Query: 283 LQGIQKIYGPPDKI 296
           L G+ ++YG  D++
Sbjct: 246 LWGLHRLYGCLDRL 259


>gi|88853069 vitronectin precursor [Homo sapiens]
          Length = 478

 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 62/192 (32%), Positives = 89/192 (46%), Gaps = 21/192 (10%)

Query: 282 DLQGIQKIYGPPDKIP--PPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAK 339
           DLQ   K  G P++ P   P    P      S P      + RP+   P  GRP  P A+
Sbjct: 101 DLQAQSK--GNPEQTPVLKPEEEAPAPEVGASKPEGI---DSRPETLHP--GRPQ-PPAE 152

Query: 340 PNICDGN-FNTLAILRR-EMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYE 397
             +C G  F+    L+   +F F+ Q+ + +    V  GYP  I   W G+   IDA + 
Sbjct: 153 EELCSGKPFDAFTDLKNGSLFAFRGQYCYELDEKAVRPGYPKLIRDVW-GIEGPIDAAFT 211

Query: 398 --NSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAI-----WWEDVGK 450
             N  G    FKG++YW F+D  L P YP ++     GIP + +D+A+      +    +
Sbjct: 212 RINCQGKTYLFKGSQYWRFEDGVLDPDYPRNISDGFDGIPDN-VDAALALPAHSYSGRER 270

Query: 451 TYFFKGDRYWRY 462
            YFFKG +YW Y
Sbjct: 271 VYFFKGKQYWEY 282



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 40/128 (31%), Positives = 69/128 (53%), Gaps = 11/128 (8%)

Query: 393 DAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDV-GKT 451
           DA  +  +G+   F+G   +   +  ++PGYP  +  +     P  ID+A    +  GKT
Sbjct: 162 DAFTDLKNGSLFAFRGQYCYELDEKAVRPGYPKLIRDVWGIEGP--IDAAFTRINCQGKT 219

Query: 452 YFFKGDRYWRYSEEMKTMDPGYPKPIT-VWKGIPESPQGAFVHKENGFT-----YFYKGK 505
           Y FKG +YWR+ + +  +DP YP+ I+  + GIP++   A     + ++     YF+KGK
Sbjct: 220 YLFKGSQYWRFEDGV--LDPDYPRNISDGFDGIPDNVDAALALPAHSYSGRERVYFFKGK 277

Query: 506 EYWKFNNQ 513
           +YW++  Q
Sbjct: 278 QYWEYQFQ 285



 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 36/108 (33%), Positives = 50/108 (46%), Gaps = 18/108 (16%)

Query: 449 GKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKE-NGFTYFYKGKEY 507
           G  + F+G   + Y  + K + PGYPK I    GI      AF      G TY +KG +Y
Sbjct: 170 GSLFAFRGQ--YCYELDEKAVRPGYPKLIRDVWGIEGPIDAAFTRINCQGKTYLFKGSQY 227

Query: 508 WKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKL 555
           W+F + +L  +P YPR+I   F G              PD+VD  + L
Sbjct: 228 WRFEDGVL--DPDYPRNISDGFDGI-------------PDNVDAALAL 260



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 21/71 (29%), Positives = 39/71 (54%), Gaps = 3/71 (4%)

Query: 467 KTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSIL 526
           +T+ PG P+P    +     P  AF   +NG  + ++G+  ++ + +   V PGYP+ ++
Sbjct: 140 ETLHPGRPQPPAEEELCSGKPFDAFTDLKNGSLFAFRGQYCYELDEK--AVRPGYPK-LI 196

Query: 527 KDFMGCDGPTD 537
           +D  G +GP D
Sbjct: 197 RDVWGIEGPID 207



 Score = 34.7 bits (78), Expect = 0.26
 Identities = 16/43 (37%), Positives = 24/43 (55%), Gaps = 4/43 (9%)

Query: 446 EDVGKTYFFKGDRYWRY---SEEMKTMDPGYPKPIT-VWKGIP 484
           E +   +FF GD+Y+R    +  + T+DP YP+ I   W G P
Sbjct: 431 EPIQSVFFFSGDKYYRVNLRTRRVDTVDPPYPRSIAQYWLGCP 473



 Score = 34.7 bits (78), Expect = 0.26
 Identities = 14/39 (35%), Positives = 25/39 (64%), Gaps = 3/39 (7%)

Query: 500 YFYKGKEYWKFN---NQILKVEPGYPRSILKDFMGCDGP 535
           +F+ G +Y++ N    ++  V+P YPRSI + ++GC  P
Sbjct: 437 FFFSGDKYYRVNLRTRRVDTVDPPYPRSIAQYWLGCPAP 475


>gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 198

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 43/105 (40%), Positives = 59/105 (56%), Gaps = 12/105 (11%)

Query: 125 QKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDI 184
           QKWQ        +N  P +   +  +A  +AF++W N + LTF     SE      D+ +
Sbjct: 21  QKWQED------QNYMPNLPQEDVDRATGKAFELWSNASALTFTRDFESE-----GDIIL 69

Query: 185 TIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWT 229
           + +F +  H D+SPF G  G LAHA+ PGPGIGGD HFD+DE  T
Sbjct: 70  SFVFLADLH-DNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRT 113



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 37/94 (39%), Positives = 56/94 (59%), Gaps = 5/94 (5%)

Query: 393 DAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHG---IDSAIWWEDVG 449
           D  ++N +     F+ +K+WV ++  L  GYP D+ +  S + P     ID+AI+ +D G
Sbjct: 103 DVHFDNDETRTKDFRSSKHWVVQEDQLLSGYPRDVYS--SFVFPERVKKIDAAIYEKDTG 160

Query: 450 KTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGI 483
           KT+FF  + YWRY E M+++D GYPK I    GI
Sbjct: 161 KTHFFVANEYWRYDENMQSVDAGYPKIIDDLPGI 194



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 32/115 (27%), Positives = 55/115 (47%), Gaps = 7/115 (6%)

Query: 421 PGYPHDLITLGSGIPPHGIDSAIWWE-DVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITV 479
           P Y HD     +  P  GI   + ++ D  +T  F+  ++W   E+   +  GYP+ +  
Sbjct: 82  PFYGHDGCLAHAFPPGPGIGGDVHFDNDETRTKDFRSSKHWVVQEDQ--LLSGYPRDVYS 139

Query: 480 WKGIPESPQ---GAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMG 531
               PE  +    A   K+ G T+F+   EYW+++  +  V+ GYP+ I+ D  G
Sbjct: 140 SFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDENMQSVDAGYPK-IIDDLPG 193



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 20/70 (28%), Positives = 36/70 (51%), Gaps = 5/70 (7%)

Query: 360 FKDQWFWRVRNNRVMDGYPMQI--TYFWRGLPPSID-AVYENSDGNFVFFKGNKYWVFKD 416
           F+    W V+ ++++ GYP  +  ++ +      ID A+YE   G   FF  N+YW + +
Sbjct: 116 FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDE 175

Query: 417 T--TLQPGYP 424
              ++  GYP
Sbjct: 176 NMQSVDAGYP 185


>gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo
           sapiens]
          Length = 183

 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 53/163 (32%), Positives = 84/163 (51%), Gaps = 24/163 (14%)

Query: 46  WLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPD 105
           +L +YGYL       +  +  E +  AL A Q+   + ++G++D  T   M++PRCG+ D
Sbjct: 31  YLSQYGYLQKPLEGSNNFKP-EDITEALRAFQEASELPVSGQLDDATRARMRQPRCGLED 89

Query: 106 QTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPL 165
                  F+ +  +Y L G +W+ KH+T+ I N+   +     R A+R+AF  W NV PL
Sbjct: 90  P------FNQKTLKYLLLG-RWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPL 142

Query: 166 TFEEVPYSELENGKRDVDITIIFASGFHGD-----SSPFDGEG 203
           TF+EV     + G  D+ ++      FHG      S+ FDG G
Sbjct: 143 TFQEV-----QAGAADIRLS------FHGRQSSYCSNTFDGPG 174


>gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 198

 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 42/105 (40%), Positives = 58/105 (55%), Gaps = 12/105 (11%)

Query: 125 QKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDI 184
           QKWQ        +N  P +   +  +A  +AF++W   + LTF     SE      D+ +
Sbjct: 21  QKWQED------QNYMPNLPQEDVDRATGKAFELWSKASALTFTRDFESE-----GDIIL 69

Query: 185 TIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWT 229
           + +F +  H D+SPF G  G LAHA+ PGPGIGGD HFD+DE  T
Sbjct: 70  SFVFLADLH-DNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRT 113



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 37/94 (39%), Positives = 56/94 (59%), Gaps = 5/94 (5%)

Query: 393 DAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHG---IDSAIWWEDVG 449
           D  ++N +     F+ +K+WV ++  L  GYP D+ +  S + P     ID+AI+ +D G
Sbjct: 103 DVHFDNDETRTKDFRSSKHWVVQEDQLLSGYPRDVYS--SFVFPERVKKIDAAIYEKDTG 160

Query: 450 KTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGI 483
           KT+FF  + YWRY E M+++D GYPK I    GI
Sbjct: 161 KTHFFVANEYWRYDENMQSVDAGYPKIIDDLPGI 194



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 32/115 (27%), Positives = 55/115 (47%), Gaps = 7/115 (6%)

Query: 421 PGYPHDLITLGSGIPPHGIDSAIWWE-DVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITV 479
           P Y HD     +  P  GI   + ++ D  +T  F+  ++W   E+   +  GYP+ +  
Sbjct: 82  PFYGHDGCLAHAFPPGPGIGGDVHFDNDETRTKDFRSSKHWVVQEDQ--LLSGYPRDVYS 139

Query: 480 WKGIPESPQ---GAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMG 531
               PE  +    A   K+ G T+F+   EYW+++  +  V+ GYP+ I+ D  G
Sbjct: 140 SFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDENMQSVDAGYPK-IIDDLPG 193



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 20/70 (28%), Positives = 36/70 (51%), Gaps = 5/70 (7%)

Query: 360 FKDQWFWRVRNNRVMDGYPMQI--TYFWRGLPPSID-AVYENSDGNFVFFKGNKYWVFKD 416
           F+    W V+ ++++ GYP  +  ++ +      ID A+YE   G   FF  N+YW + +
Sbjct: 116 FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDE 175

Query: 417 T--TLQPGYP 424
              ++  GYP
Sbjct: 176 NMQSVDAGYP 185


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.141    0.465 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,690,732
Number of Sequences: 37866
Number of extensions: 1689049
Number of successful extensions: 12747
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 176
Number of HSP's successfully gapped in prelim test: 281
Number of HSP's that attempted gapping in prelim test: 8505
Number of HSP's gapped (non-prelim): 3016
length of query: 607
length of database: 18,247,518
effective HSP length: 108
effective length of query: 499
effective length of database: 14,157,990
effective search space: 7064837010
effective search space used: 7064837010
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.