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Search of human proteins with 12746412
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo
sapiens]
(313 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo sapi... 629 0.0
gi|4506499 regulatory factor X-associated ankyrin-containing pro... 241 5e-64
gi|19924156 regulatory factor X-associated ankyrin-containing pr... 212 3e-55
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 87 1e-17
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 84 1e-16
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 84 1e-16
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 79 4e-15
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 79 4e-15
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 79 5e-15
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 79 5e-15
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 79 7e-15
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 79 7e-15
gi|62420875 integrin-linked kinase [Homo sapiens] 78 9e-15
gi|62420873 integrin-linked kinase [Homo sapiens] 78 9e-15
gi|4758606 integrin-linked kinase [Homo sapiens] 78 9e-15
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 78 9e-15
gi|148596917 fibronectin type III and ankyrin repeat domains 1 [... 78 1e-14
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 78 1e-14
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 77 2e-14
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 77 3e-14
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 77 3e-14
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 77 3e-14
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 77 3e-14
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 77 3e-14
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 76 3e-14
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 76 3e-14
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 75 7e-14
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 75 7e-14
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 75 7e-14
gi|23510377 KN motif and ankyrin repeat domains 1 isoform b [Hom... 75 1e-13
>gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo
sapiens]
Length = 313
Score = 629 bits (1623), Expect = 0.0
Identities = 313/313 (100%), Positives = 313/313 (100%)
Query: 1 MDTSTNLDIGAQLIVEECPSTYSLTGMPDIKIEHPLDPNSEEGSAQGVAMGMKFILPNRF 60
MDTSTNLDIGAQLIVEECPSTYSLTGMPDIKIEHPLDPNSEEGSAQGVAMGMKFILPNRF
Sbjct: 1 MDTSTNLDIGAQLIVEECPSTYSLTGMPDIKIEHPLDPNSEEGSAQGVAMGMKFILPNRF 60
Query: 61 DMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHTSPSPGIQVRHVYTPSTT 120
DMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHTSPSPGIQVRHVYTPSTT
Sbjct: 61 DMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHTSPSPGIQVRHVYTPSTT 120
Query: 121 KHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDE 180
KHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDE
Sbjct: 121 KHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDE 180
Query: 181 EGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVD 240
EGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVD
Sbjct: 181 EGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVD 240
Query: 241 VNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
VNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI
Sbjct: 241 VNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
Query: 301 ESHLLKLLQNIKE 313
ESHLLKLLQNIKE
Sbjct: 301 ESHLLKLLQNIKE 313
>gi|4506499 regulatory factor X-associated ankyrin-containing
protein isoform a [Homo sapiens]
Length = 260
Score = 241 bits (616), Expect = 5e-64
Identities = 122/188 (64%), Positives = 145/188 (77%), Gaps = 1/188 (0%)
Query: 124 SPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQ-ENVINHTDEEG 182
S +K STTLTN+ RGNEVS P +SLS+HQLAAQGE+ L + + +N++N DE G
Sbjct: 65 SSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERG 124
Query: 183 FTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVN 242
FTPL+WA+A G+I V FLL+ GADP +L K RESALSLA + GYTDIV +LL+ VD+N
Sbjct: 125 FTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDIN 184
Query: 243 EYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIES 302
YDWNGGTPLLYAV GNHVKCV+ LL GAD T E DSGY MDLAVALGYR VQQVIE+
Sbjct: 185 IYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 244
Query: 303 HLLKLLQN 310
H+LKL Q+
Sbjct: 245 HILKLFQS 252
>gi|19924156 regulatory factor X-associated ankyrin-containing
protein isoform b [Homo sapiens]
Length = 237
Score = 212 bits (540), Expect = 3e-55
Identities = 110/187 (58%), Positives = 130/187 (69%), Gaps = 21/187 (11%)
Query: 124 SPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGF 183
S +K STTLTN+ RGNEVS P ++ +N++N DE GF
Sbjct: 64 SSLKHSTTLTNRQRGNEVSALP---------------------ATLDCDNLVNKPDERGF 102
Query: 184 TPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNE 243
TPL+WA+A G+I V FLL+ GADP +L K RESALSLA + GYTDIV +LL+ VD+N
Sbjct: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
Query: 244 YDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESH 303
YDWNGGTPLLYAV GNHVKCV+ LL GAD T E DSGY MDLAVALGYR VQQVIE+H
Sbjct: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
Query: 304 LLKLLQN 310
+LKL Q+
Sbjct: 223 ILKLFQS 229
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 87.4 bits (215), Expect = 1e-17
Identities = 50/128 (39%), Positives = 74/128 (57%), Gaps = 1/128 (0%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
+ H D G+T LMWA G+ VVE LL +GA+P + G + A +G+ DIV +L
Sbjct: 97 LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLL 156
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGY- 293
L G VN D G TPL++A H++CVK LL GAD E + ++ +AV GY
Sbjct: 157 LQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYT 216
Query: 294 RSVQQVIE 301
+SV+++++
Sbjct: 217 QSVKEILK 224
Score = 70.1 bits (170), Expect = 2e-12
Identities = 42/127 (33%), Positives = 69/127 (54%)
Query: 150 SLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQ 209
S SV + + L +E+ ++ +E G TPLM AA G + +V+ L++NGA+
Sbjct: 6 SQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCN 65
Query: 210 LLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLE 269
L +AL A +G+ IV+ LL CGV++ D G T L++A + V++LL
Sbjct: 66 LEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLS 125
Query: 270 SGADPTI 276
GA+P++
Sbjct: 126 HGANPSV 132
Score = 68.6 bits (166), Expect = 7e-12
Identities = 44/126 (34%), Positives = 65/126 (51%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
+N +D+ G TPL+WAA G + V+ LL GAD G +AL +A GYT VK +
Sbjct: 163 VNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEI 222
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYR 294
L +VN D +G T L+ A H + V+ LL++G I SG + AV G+
Sbjct: 223 LKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHV 282
Query: 295 SVQQVI 300
+ + +
Sbjct: 283 EIVRAL 288
Score = 64.3 bits (155), Expect = 1e-10
Identities = 37/114 (32%), Positives = 57/114 (50%)
Query: 185 PLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEY 244
P++WAA G +V LLQNGA K + L A KG+ + VK LL G DV++
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199
Query: 245 DWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQ 298
N T L+ AV G + + VK +L+ + + G ++ +A G+ + Q
Sbjct: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
Score = 60.8 bits (146), Expect = 1e-09
Identities = 36/126 (28%), Positives = 63/126 (50%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
+N D G T L+ A G + +V LLQ AD + G+ ++AL A KG +V+ +
Sbjct: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYR 294
L C D +G TPL+ A +++ V++LL+ GA + G + +A+ R
Sbjct: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 381
Query: 295 SVQQVI 300
+ +++
Sbjct: 382 KLAELL 387
Score = 52.4 bits (124), Expect = 5e-07
Identities = 30/94 (31%), Positives = 46/94 (48%)
Query: 180 EEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGV 239
++ T L WA G +V +LQ D ++ K E+ L A ++V++LLD G
Sbjct: 300 QDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGA 359
Query: 240 DVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGAD 273
V+ D G TPL A+ G K ++LL + D
Sbjct: 360 KVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393
Score = 43.1 bits (100), Expect = 3e-04
Identities = 34/132 (25%), Positives = 60/132 (45%), Gaps = 12/132 (9%)
Query: 172 ENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIV 231
++VIN+ +EE I ++ LL+ D + ++ L +A +G +IV
Sbjct: 7 QSVINYVEEEN------------IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIV 54
Query: 232 KMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVAL 291
K L+ G + N D + T L+ A HV V+ LL+ G + G+ ++ A
Sbjct: 55 KELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYK 114
Query: 292 GYRSVQQVIESH 303
G V +++ SH
Sbjct: 115 GRTDVVELLLSH 126
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 84.3 bits (207), Expect = 1e-16
Identities = 52/146 (35%), Positives = 83/146 (56%), Gaps = 3/146 (2%)
Query: 158 AQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG-KGRE 216
A G + T +E+ I H D++GFTPL+ AA G + VVE LL NGAD + + ++
Sbjct: 1092 AGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD 1151
Query: 217 SALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTI 276
+ LSLACS G ++V++LL G + + + TPL A G +V +K+LL +GA+
Sbjct: 1152 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 1211
Query: 277 ETDS--GYNSMDLAVALGYRSVQQVI 300
T S G + + LA G+ + +++
Sbjct: 1212 RTGSKLGISPLMLAAMNGHTAAVKLL 1237
Score = 76.3 bits (186), Expect = 3e-14
Identities = 48/147 (32%), Positives = 75/147 (51%), Gaps = 12/147 (8%)
Query: 138 GNEVSTTPLLANSLSVHQLAAQGEMLYLAT------RIEQENVINHTDEEG------FTP 185
G+ + LL SV++ +GE L + Q + H + E TP
Sbjct: 245 GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITP 304
Query: 186 LMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYD 245
LM AA G + +V+ LL + AD +AL+ AC+ GY D+VK+LL+ G + +++
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
Query: 246 WNGGTPLLYAVHGNHVKCVKMLLESGA 272
NG TPL+ A HV+ ++LLE+GA
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGA 391
Score = 73.9 bits (180), Expect = 2e-13
Identities = 54/190 (28%), Positives = 86/190 (45%), Gaps = 25/190 (13%)
Query: 139 NEVSTTPLLANSLSVHQ-----LAAQGEMLYLATRIEQENVINHTDEEGF---------- 183
N+ TPL+ + H+ L QG + T QE + GF
Sbjct: 497 NDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKA 556
Query: 184 ---------TPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
TPLM AA G + +V++LL GA+ ++AL+ AC G+TD+ +L
Sbjct: 557 GADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVL 616
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIET-DSGYNSMDLAVALGY 293
L G D+ G TPL+ A HV V+ L+ GA+ T ++ + + LA A G+
Sbjct: 617 LQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGH 676
Query: 294 RSVQQVIESH 303
+V +++ +H
Sbjct: 677 LAVVELLLAH 686
Score = 70.9 bits (172), Expect = 1e-12
Identities = 46/145 (31%), Positives = 74/145 (51%), Gaps = 4/145 (2%)
Query: 157 AAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQL-LGKGR 215
A G + A IE+ + ++EG+TPLM AA G +V LL GA+ + +
Sbjct: 475 ACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQ 534
Query: 216 ESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPT 275
E+AL+LAC G+ ++ L+ G D+ + TPL+ A H++ VK LL +GA+
Sbjct: 535 ETALTLACCGGFLEVADFLIKAGADI---ELGCSTPLMEAAQEGHLELVKYLLAAGANVH 591
Query: 276 IETDSGYNSMDLAVALGYRSVQQVI 300
T +G ++ A G+ V V+
Sbjct: 592 ATTATGDTALTYACENGHTDVADVL 616
Score = 67.8 bits (164), Expect = 1e-11
Identities = 43/188 (22%), Positives = 90/188 (47%), Gaps = 7/188 (3%)
Query: 88 LEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLL 147
+ + +L A I++ + + + + H + +K + G++++
Sbjct: 1196 VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDM-----GSDINAQIET 1250
Query: 148 ANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
+ ++ QG ++ ++++ + H + G TPLM AA+ G V LL GAD
Sbjct: 1251 NRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1310
Query: 208 PQL--LGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVK 265
+ R++AL++A KG+ ++L+ G ++ + G TPL A +G H+ V+
Sbjct: 1311 VNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQ 1370
Query: 266 MLLESGAD 273
+L+++GAD
Sbjct: 1371 LLVQAGAD 1378
Score = 64.3 bits (155), Expect = 1e-10
Identities = 48/161 (29%), Positives = 73/161 (45%), Gaps = 12/161 (7%)
Query: 139 NEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQEN---VINHTDEEGFTPLMWAAAHGQI 195
NE TPL+ + H A R+ EN + H++E + L A G +
Sbjct: 364 NENGHTPLMEAGSAGHVEVA---------RLLLENGAGINTHSNEFKESALTLACYKGHL 414
Query: 196 AVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYA 255
+V FLL+ GAD + +AL AC G+ ++ ++LLD G VN + +PL A
Sbjct: 415 EMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLA 474
Query: 256 VHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSV 296
G HV+ +L+E GA D GY + A G+ +
Sbjct: 475 ACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM 515
Score = 63.5 bits (153), Expect = 2e-10
Identities = 45/154 (29%), Positives = 79/154 (51%), Gaps = 1/154 (0%)
Query: 148 ANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
+++ S+ + ++G++ + + + +N EEG + L A + G + + LL A+
Sbjct: 233 SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 292
Query: 208 PQLLG-KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKM 266
+ G KG + L A + G+ IVK+LL DVN G T L YA G +V VK+
Sbjct: 293 VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKV 352
Query: 267 LLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
LLESGA ++G+ + A + G+ V +++
Sbjct: 353 LLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386
Score = 60.1 bits (144), Expect = 2e-09
Identities = 37/121 (30%), Positives = 60/121 (49%), Gaps = 1/121 (0%)
Query: 177 HTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLD 236
H +E T LM A G + V LL +GA + ES L+LA G+ ++ +L++
Sbjct: 429 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 488
Query: 237 CGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIET-DSGYNSMDLAVALGYRS 295
G + E + G TPL+ A H + V +LL GA+ +T ++ ++ LA G+
Sbjct: 489 RGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLE 548
Query: 296 V 296
V
Sbjct: 549 V 549
Score = 59.7 bits (143), Expect = 3e-09
Identities = 35/96 (36%), Positives = 50/96 (52%), Gaps = 1/96 (1%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADP-QLLGKGRESALSLACSKGYTDIVKM 233
+ H E G TPLM AA G + V+FL+ GA+ + + LSLAC+ G+ +V++
Sbjct: 623 LEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVEL 682
Query: 234 LLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLE 269
LL G D +G T L+ A G H V LL+
Sbjct: 683 LLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 59.3 bits (142), Expect = 4e-09
Identities = 50/175 (28%), Positives = 83/175 (47%), Gaps = 16/175 (9%)
Query: 137 RGNEVSTTPLLANSLSVHQ--------LAAQGEML--YLATRIEQENVINHTDEEGFTPL 186
R + +S TP + + S+ Q + + ML Y A I+ + NH T L
Sbjct: 1033 RASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHD-----TAL 1087
Query: 187 MWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVN-EYD 245
A A G +V+ LL+ GA + K + L LA + G+ +V++LLD G D+ + +
Sbjct: 1088 TLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSE 1147
Query: 246 WNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
TPL A G + V++LL GA+ S Y + LA + GY ++ +++
Sbjct: 1148 RTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1202
Score = 45.1 bits (105), Expect = 8e-05
Identities = 35/123 (28%), Positives = 52/123 (42%), Gaps = 34/123 (27%)
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGG---------------------- 249
G+ +L+ ACS+G + V+ LL G VNE+ G
Sbjct: 231 GQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 290
Query: 250 ------------TPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQ 297
TPL+ A +G HVK VK+LL AD ++ +G ++ A A GY V
Sbjct: 291 ANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVV 350
Query: 298 QVI 300
+V+
Sbjct: 351 KVL 353
Score = 44.7 bits (104), Expect = 1e-04
Identities = 42/149 (28%), Positives = 62/149 (41%), Gaps = 7/149 (4%)
Query: 88 LEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLL 147
LE+ L A N+H + + G + + + +H +E TPL+
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE-SEGGRTPLM 635
Query: 148 ANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
+ + H Q +L ++ NV T T L A A G +AVVE LL +GAD
Sbjct: 636 KAARAGHVCTVQ----FLISK--GANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGAD 689
Query: 208 PQLLGKGRESALSLACSKGYTDIVKMLLD 236
P K + L A G+T +V LLD
Sbjct: 690 PTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 40.4 bits (93), Expect = 0.002
Identities = 30/109 (27%), Positives = 57/109 (52%), Gaps = 4/109 (3%)
Query: 137 RGNEVSTTPLLANSLSVHQLAA-QGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQI 195
+G +V+ P+ ++ + +AA +G + I + I+ +++G TPL AA G +
Sbjct: 1307 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHL 1366
Query: 196 AVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEY 244
VV+ L+Q GAD + + L A KG+ +V+ L+ +VN++
Sbjct: 1367 DVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK---EVNQF 1412
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 84.3 bits (207), Expect = 1e-16
Identities = 52/146 (35%), Positives = 83/146 (56%), Gaps = 3/146 (2%)
Query: 158 AQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG-KGRE 216
A G + T +E+ I H D++GFTPL+ AA G + VVE LL NGAD + + ++
Sbjct: 841 AGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD 900
Query: 217 SALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTI 276
+ LSLACS G ++V++LL G + + + TPL A G +V +K+LL +GA+
Sbjct: 901 TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINS 960
Query: 277 ETDS--GYNSMDLAVALGYRSVQQVI 300
T S G + + LA G+ + +++
Sbjct: 961 RTGSKLGISPLMLAAMNGHTAAVKLL 986
Score = 76.3 bits (186), Expect = 3e-14
Identities = 48/147 (32%), Positives = 75/147 (51%), Gaps = 12/147 (8%)
Query: 138 GNEVSTTPLLANSLSVHQLAAQGEMLYLAT------RIEQENVINHTDEEG------FTP 185
G+ + LL SV++ +GE L + Q + H + E TP
Sbjct: 245 GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITP 304
Query: 186 LMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYD 245
LM AA G + +V+ LL + AD +AL+ AC+ GY D+VK+LL+ G + +++
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
Query: 246 WNGGTPLLYAVHGNHVKCVKMLLESGA 272
NG TPL+ A HV+ ++LLE+GA
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGA 391
Score = 73.9 bits (180), Expect = 2e-13
Identities = 54/190 (28%), Positives = 86/190 (45%), Gaps = 25/190 (13%)
Query: 139 NEVSTTPLLANSLSVHQ-----LAAQGEMLYLATRIEQENVINHTDEEGF---------- 183
N+ TPL+ + H+ L QG + T QE + GF
Sbjct: 497 NDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKA 556
Query: 184 ---------TPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
TPLM AA G + +V++LL GA+ ++AL+ AC G+TD+ +L
Sbjct: 557 GADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVL 616
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIET-DSGYNSMDLAVALGY 293
L G D+ G TPL+ A HV V+ L+ GA+ T ++ + + LA A G+
Sbjct: 617 LQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGH 676
Query: 294 RSVQQVIESH 303
+V +++ +H
Sbjct: 677 LAVVELLLAH 686
Score = 70.9 bits (172), Expect = 1e-12
Identities = 46/145 (31%), Positives = 74/145 (51%), Gaps = 4/145 (2%)
Query: 157 AAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQL-LGKGR 215
A G + A IE+ + ++EG+TPLM AA G +V LL GA+ + +
Sbjct: 475 ACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQ 534
Query: 216 ESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPT 275
E+AL+LAC G+ ++ L+ G D+ + TPL+ A H++ VK LL +GA+
Sbjct: 535 ETALTLACCGGFLEVADFLIKAGADI---ELGCSTPLMEAAQEGHLELVKYLLAAGANVH 591
Query: 276 IETDSGYNSMDLAVALGYRSVQQVI 300
T +G ++ A G+ V V+
Sbjct: 592 ATTATGDTALTYACENGHTDVADVL 616
Score = 67.8 bits (164), Expect = 1e-11
Identities = 43/188 (22%), Positives = 90/188 (47%), Gaps = 7/188 (3%)
Query: 88 LEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLL 147
+ + +L A I++ + + + + H + +K + G++++
Sbjct: 945 VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDM-----GSDINAQIET 999
Query: 148 ANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
+ ++ QG ++ ++++ + H + G TPLM AA+ G V LL GAD
Sbjct: 1000 NRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1059
Query: 208 PQL--LGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVK 265
+ R++AL++A KG+ ++L+ G ++ + G TPL A +G H+ V+
Sbjct: 1060 VNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQ 1119
Query: 266 MLLESGAD 273
+L+++GAD
Sbjct: 1120 LLVQAGAD 1127
Score = 64.3 bits (155), Expect = 1e-10
Identities = 48/161 (29%), Positives = 73/161 (45%), Gaps = 12/161 (7%)
Query: 139 NEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQEN---VINHTDEEGFTPLMWAAAHGQI 195
NE TPL+ + H A R+ EN + H++E + L A G +
Sbjct: 364 NENGHTPLMEAGSAGHVEVA---------RLLLENGAGINTHSNEFKESALTLACYKGHL 414
Query: 196 AVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYA 255
+V FLL+ GAD + +AL AC G+ ++ ++LLD G VN + +PL A
Sbjct: 415 EMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLA 474
Query: 256 VHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSV 296
G HV+ +L+E GA D GY + A G+ +
Sbjct: 475 ACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM 515
Score = 63.5 bits (153), Expect = 2e-10
Identities = 45/154 (29%), Positives = 79/154 (51%), Gaps = 1/154 (0%)
Query: 148 ANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
+++ S+ + ++G++ + + + +N EEG + L A + G + + LL A+
Sbjct: 233 SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 292
Query: 208 PQLLG-KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKM 266
+ G KG + L A + G+ IVK+LL DVN G T L YA G +V VK+
Sbjct: 293 VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKV 352
Query: 267 LLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
LLESGA ++G+ + A + G+ V +++
Sbjct: 353 LLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386
Score = 63.2 bits (152), Expect = 3e-10
Identities = 57/217 (26%), Positives = 99/217 (45%), Gaps = 21/217 (9%)
Query: 100 NIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKH-----RGNEVSTTPLLANSLSVH 154
+++ +P +Q + P P +TTL ++ R + +S TP + + S+
Sbjct: 740 DLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASIS 799
Query: 155 Q--------LAAQGEML--YLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQN 204
Q + + ML Y A I+ + NH T L A A G +V+ LL+
Sbjct: 800 QPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHD-----TALTLACAGGHEELVQTLLER 854
Query: 205 GADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVN-EYDWNGGTPLLYAVHGNHVKC 263
GA + K + L LA + G+ +V++LLD G D+ + + TPL A G +
Sbjct: 855 GASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEV 914
Query: 264 VKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
V++LL GA+ S Y + LA + GY ++ +++
Sbjct: 915 VELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 951
Score = 60.1 bits (144), Expect = 2e-09
Identities = 37/121 (30%), Positives = 60/121 (49%), Gaps = 1/121 (0%)
Query: 177 HTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLD 236
H +E T LM A G + V LL +GA + ES L+LA G+ ++ +L++
Sbjct: 429 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 488
Query: 237 CGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIET-DSGYNSMDLAVALGYRS 295
G + E + G TPL+ A H + V +LL GA+ +T ++ ++ LA G+
Sbjct: 489 RGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLE 548
Query: 296 V 296
V
Sbjct: 549 V 549
Score = 59.7 bits (143), Expect = 3e-09
Identities = 35/96 (36%), Positives = 50/96 (52%), Gaps = 1/96 (1%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADP-QLLGKGRESALSLACSKGYTDIVKM 233
+ H E G TPLM AA G + V+FL+ GA+ + + LSLAC+ G+ +V++
Sbjct: 623 LEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVEL 682
Query: 234 LLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLE 269
LL G D +G T L+ A G H V LL+
Sbjct: 683 LLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 45.1 bits (105), Expect = 8e-05
Identities = 35/123 (28%), Positives = 52/123 (42%), Gaps = 34/123 (27%)
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGG---------------------- 249
G+ +L+ ACS+G + V+ LL G VNE+ G
Sbjct: 231 GQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 290
Query: 250 ------------TPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQ 297
TPL+ A +G HVK VK+LL AD ++ +G ++ A A GY V
Sbjct: 291 ANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVV 350
Query: 298 QVI 300
+V+
Sbjct: 351 KVL 353
Score = 44.7 bits (104), Expect = 1e-04
Identities = 42/149 (28%), Positives = 62/149 (41%), Gaps = 7/149 (4%)
Query: 88 LEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLL 147
LE+ L A N+H + + G + + + +H +E TPL+
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE-SEGGRTPLM 635
Query: 148 ANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
+ + H Q +L ++ NV T T L A A G +AVVE LL +GAD
Sbjct: 636 KAARAGHVCTVQ----FLISK--GANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGAD 689
Query: 208 PQLLGKGRESALSLACSKGYTDIVKMLLD 236
P K + L A G+T +V LLD
Sbjct: 690 PTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 40.4 bits (93), Expect = 0.002
Identities = 30/109 (27%), Positives = 57/109 (52%), Gaps = 4/109 (3%)
Query: 137 RGNEVSTTPLLANSLSVHQLAA-QGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQI 195
+G +V+ P+ ++ + +AA +G + I + I+ +++G TPL AA G +
Sbjct: 1056 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHL 1115
Query: 196 AVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEY 244
VV+ L+Q GAD + + L A KG+ +V+ L+ +VN++
Sbjct: 1116 DVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK---EVNQF 1161
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 79.3 bits (194), Expect = 4e-15
Identities = 52/140 (37%), Positives = 73/140 (52%)
Query: 157 AAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRE 216
A QG + +E+ +N +D++G TPLM AA G ++ VEFLL GA L K
Sbjct: 1112 ARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1171
Query: 217 SALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTI 276
SALS AC KG+ +V+ L++ G +++ D NG TPL A + V L+E GA
Sbjct: 1172 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1231
Query: 277 ETDSGYNSMDLAVALGYRSV 296
SG +D A+ SV
Sbjct: 1232 VDHSGMRPLDRAIGCRNTSV 1251
Score = 66.2 bits (160), Expect = 3e-11
Identities = 46/132 (34%), Positives = 66/132 (50%), Gaps = 1/132 (0%)
Query: 170 EQENVINHTDEE-GFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYT 228
E E +N TD G T L AA G++ V E LL +GA + L A +G+
Sbjct: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
Query: 229 DIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLA 288
IV++LL+ G DVN D G TPL+ A H+ V+ LL GA + G +++ A
Sbjct: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1177
Query: 289 VALGYRSVQQVI 300
G+R+V Q +
Sbjct: 1178 CLKGHRAVVQYL 1189
Score = 62.8 bits (151), Expect = 4e-10
Identities = 49/193 (25%), Positives = 79/193 (40%), Gaps = 5/193 (2%)
Query: 105 PSPGI-----QVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQ 159
P PG ++ T + + S + Q K EV+ T L ++ A +
Sbjct: 1022 PQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1081
Query: 160 GEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESAL 219
G++ + ++ T+ G PL AA G +V LL+ G D L K + L
Sbjct: 1082 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1141
Query: 220 SLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETD 279
+A +G+ V+ LL G ++ D G + L +A H V+ L+E GA
Sbjct: 1142 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1201
Query: 280 SGYNSMDLAVALG 292
+G +DLA G
Sbjct: 1202 NGRTPLDLAAFYG 1214
Score = 53.1 bits (126), Expect = 3e-07
Identities = 33/116 (28%), Positives = 54/116 (46%)
Query: 157 AAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRE 216
A +G + + + + ++ D+EG + L WA G AVV++L++ GA K
Sbjct: 1145 ACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGR 1204
Query: 217 SALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+ L LA G + V L++ G + D +G PL A+ + V LL GA
Sbjct: 1205 TPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
Score = 47.0 bits (110), Expect = 2e-05
Identities = 33/119 (27%), Positives = 57/119 (47%), Gaps = 5/119 (4%)
Query: 189 AAAHGQIAVVEFLLQNGADPQLLGKGR-----ESALSLACSKGYTDIVKMLLDCGVDVNE 243
AA+ G +VV+ LL + ++ G E+AL+ A +G ++ ++LL G V+
Sbjct: 1040 AASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSR 1099
Query: 244 YDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIES 302
+ G PL A H + V++LLE G D + G + +A G+ S + + S
Sbjct: 1100 TNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLS 1158
Score = 40.8 bits (94), Expect = 0.002
Identities = 25/77 (32%), Positives = 39/77 (50%), Gaps = 7/77 (9%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
++ T E G T L +AAA G + +V L + G L K + AL + +G+ DI++ L
Sbjct: 953 LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYL 1012
Query: 235 LDCGVDVNEYDWNGGTP 251
L C +W+ G P
Sbjct: 1013 LTC-------EWSPGPP 1022
Score = 33.1 bits (74), Expect = 0.33
Identities = 16/46 (34%), Positives = 26/46 (56%)
Query: 226 GYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESG 271
G+ ++V +LL+ G ++ NG T L YA H+K V +L + G
Sbjct: 938 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKG 983
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 79.3 bits (194), Expect = 4e-15
Identities = 52/140 (37%), Positives = 73/140 (52%)
Query: 157 AAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRE 216
A QG + +E+ +N +D++G TPLM AA G ++ VEFLL GA L K
Sbjct: 1120 ARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGL 1179
Query: 217 SALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTI 276
SALS AC KG+ +V+ L++ G +++ D NG TPL A + V L+E GA
Sbjct: 1180 SALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEH 1239
Query: 277 ETDSGYNSMDLAVALGYRSV 296
SG +D A+ SV
Sbjct: 1240 VDHSGMRPLDRAIGCRNTSV 1259
Score = 66.2 bits (160), Expect = 3e-11
Identities = 46/132 (34%), Positives = 66/132 (50%), Gaps = 1/132 (0%)
Query: 170 EQENVINHTDEE-GFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYT 228
E E +N TD G T L AA G++ V E LL +GA + L A +G+
Sbjct: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
Query: 229 DIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLA 288
IV++LL+ G DVN D G TPL+ A H+ V+ LL GA + G +++ A
Sbjct: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWA 1185
Query: 289 VALGYRSVQQVI 300
G+R+V Q +
Sbjct: 1186 CLKGHRAVVQYL 1197
Score = 62.8 bits (151), Expect = 4e-10
Identities = 49/193 (25%), Positives = 79/193 (40%), Gaps = 5/193 (2%)
Query: 105 PSPGI-----QVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQ 159
P PG ++ T + + S + Q K EV+ T L ++ A +
Sbjct: 1030 PQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGR 1089
Query: 160 GEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESAL 219
G++ + ++ T+ G PL AA G +V LL+ G D L K + L
Sbjct: 1090 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1149
Query: 220 SLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETD 279
+A +G+ V+ LL G ++ D G + L +A H V+ L+E GA
Sbjct: 1150 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 1209
Query: 280 SGYNSMDLAVALG 292
+G +DLA G
Sbjct: 1210 NGRTPLDLAAFYG 1222
Score = 53.1 bits (126), Expect = 3e-07
Identities = 33/116 (28%), Positives = 54/116 (46%)
Query: 157 AAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRE 216
A +G + + + + ++ D+EG + L WA G AVV++L++ GA K
Sbjct: 1153 ACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGR 1212
Query: 217 SALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+ L LA G + V L++ G + D +G PL A+ + V LL GA
Sbjct: 1213 TPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
Score = 47.0 bits (110), Expect = 2e-05
Identities = 33/119 (27%), Positives = 57/119 (47%), Gaps = 5/119 (4%)
Query: 189 AAAHGQIAVVEFLLQNGADPQLLGKGR-----ESALSLACSKGYTDIVKMLLDCGVDVNE 243
AA+ G +VV+ LL + ++ G E+AL+ A +G ++ ++LL G V+
Sbjct: 1048 AASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSR 1107
Query: 244 YDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIES 302
+ G PL A H + V++LLE G D + G + +A G+ S + + S
Sbjct: 1108 TNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLS 1166
Score = 40.8 bits (94), Expect = 0.002
Identities = 25/77 (32%), Positives = 39/77 (50%), Gaps = 7/77 (9%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
++ T E G T L +AAA G + +V L + G L K + AL + +G+ DI++ L
Sbjct: 961 LDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYL 1020
Query: 235 LDCGVDVNEYDWNGGTP 251
L C +W+ G P
Sbjct: 1021 LTC-------EWSPGPP 1030
Score = 33.1 bits (74), Expect = 0.33
Identities = 16/46 (34%), Positives = 26/46 (56%)
Query: 226 GYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESG 271
G+ ++V +LL+ G ++ NG T L YA H+K V +L + G
Sbjct: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKG 991
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 79.0 bits (193), Expect = 5e-15
Identities = 46/142 (32%), Positives = 77/142 (54%), Gaps = 1/142 (0%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
++H A G + +A I + D++G+TPL AA++GQI VV+ LL G + +
Sbjct: 151 ALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEI 210
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNH-VKCVKMLLES 270
+AL +AC G +V L+D G +VN+ + NG TPL +A H C+++L+ +
Sbjct: 211 NVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNN 270
Query: 271 GADPTIETDSGYNSMDLAVALG 292
GAD I++ G + + + G
Sbjct: 271 GADVNIQSKDGKSPLHMTAVHG 292
Score = 63.9 bits (154), Expect = 2e-10
Identities = 40/121 (33%), Positives = 59/121 (48%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A G T I+ I+ D++G TPL AA +G ++ L +GAD G
Sbjct: 285 LHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCG 344
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
L LA ++D + LL G +++ D G T L A G +V+C+K+L SGA
Sbjct: 345 IHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGA 404
Query: 273 D 273
D
Sbjct: 405 D 405
Score = 60.8 bits (146), Expect = 1e-09
Identities = 39/139 (28%), Positives = 67/139 (48%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
++H A G + + + + IN D++ L WAA G + VV L+ +GA+
Sbjct: 118 ALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK 177
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESG 271
K + L A S G ++VK LL+ GV+++E + G T L A + V L++ G
Sbjct: 178 DKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYG 237
Query: 272 ADPTIETDSGYNSMDLAVA 290
A+ ++G+ + A A
Sbjct: 238 ANVNQPNNNGFTPLHFAAA 256
Score = 60.5 bits (145), Expect = 2e-09
Identities = 47/148 (31%), Positives = 72/148 (48%), Gaps = 6/148 (4%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFT--PLMWAAAHGQIAVVEFLLQNGADPQ 209
S+H AA G L +E+ N + G T PL AA +G +E LLQ+ D
Sbjct: 510 SIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLD 569
Query: 210 LLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYD-WNGGTPLLYAVHGNHVKCVKMLL 268
+ + +AL LA KG+T+ V+ L++ G + D TPL +V H C+++LL
Sbjct: 570 IRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLL 629
Query: 269 ESGADP---TIETDSGYNSMDLAVALGY 293
E +P ++ G + LAVA G+
Sbjct: 630 EIADNPEAVDVKDAKGQTPLMLAVAYGH 657
Score = 58.9 bits (141), Expect = 6e-09
Identities = 42/161 (26%), Positives = 73/161 (45%), Gaps = 4/161 (2%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H+ A + I+ +N D+ TPL AAA+ + E ++ + +
Sbjct: 53 LHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSD 112
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+G +AL A G+ ++V +LL G ++N +D L +A + H+ V +L+ GA
Sbjct: 113 RGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGA 172
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE 313
+ T + GY + A + G Q + HLL L I E
Sbjct: 173 EVTCKDKKGYTPLHAAASNG----QINVVKHLLNLGVEIDE 209
Score = 53.9 bits (128), Expect = 2e-07
Identities = 43/154 (27%), Positives = 68/154 (44%), Gaps = 28/154 (18%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
I+ D+ G T L AAA G + ++ L +GAD K + L A + + ++ L
Sbjct: 373 IDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETL 432
Query: 235 LDCGVDVNEYDWNGGTPLLYAV--------------HGNHVK--------------CVKM 266
+ G +VNE D G T L YA H N + C++
Sbjct: 433 VTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEF 492
Query: 267 LLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
LL++ A+P+I GYNS+ A A G+R +++
Sbjct: 493 LLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELL 526
Score = 51.2 bits (121), Expect = 1e-06
Identities = 47/188 (25%), Positives = 78/188 (41%), Gaps = 37/188 (19%)
Query: 136 HRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQ- 194
H+ ++ TPL H AA + T + +N TD+ G T L +AAA
Sbjct: 407 HKKDKCGRTPL-------HYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMD 459
Query: 195 ---------------------------IAVVEFLLQNGADPQLLGKGRESALSLACSKGY 227
+EFLLQN A+P + K +++ A + G+
Sbjct: 460 RNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGH 519
Query: 228 TDIVKMLLDCGVDVNEYDWNGGT--PLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSM 285
+++LL+ E +G T PL A + H + +++LL+S D I + G ++
Sbjct: 520 RQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTAL 579
Query: 286 DLAVALGY 293
DLA G+
Sbjct: 580 DLAAFKGH 587
Score = 51.2 bits (121), Expect = 1e-06
Identities = 55/224 (24%), Positives = 93/224 (41%), Gaps = 26/224 (11%)
Query: 88 LEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIK-----QSTTLTNKHRGNEVS 142
++ S+L + E N+ T G H T H ++ + + L RG
Sbjct: 658 IDAVSLLLEKEANVDTVDILGCTALH--RGIMTGHEECVQMLLEQEVSILCKDSRGR--- 712
Query: 143 TTPLLANSLSVHQLAAQGEMLYLATRIEQ---ENVINHTDEEGFTPLMWAAAHGQIAVVE 199
TPL H AA+G +L+ ++ E D +G+TPL WA +G +E
Sbjct: 713 -TPL-------HYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIE 764
Query: 200 FLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVD---VNEYDWNGGTPLLYAV 256
LL+ + +G + L A + + +LL +D V+ D G TPL A
Sbjct: 765 VLLEQKCFRKFIGNPF-TPLHCAIINDHGNCASLLLGA-IDSSIVSCRDDKGRTPLRAAA 822
Query: 257 HGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
+HV+C+++LL A +SG ++ +A G ++
Sbjct: 823 FADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL 866
Score = 49.3 bits (116), Expect = 4e-06
Identities = 41/169 (24%), Positives = 68/169 (40%), Gaps = 6/169 (3%)
Query: 134 NKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHG 193
N ++ N TPL + S H L L + +N ++G +PL A HG
Sbjct: 239 NVNQPNNNGFTPLHFAAASTHGA------LCLELLVNNGADVNIQSKDGKSPLHMTAVHG 292
Query: 194 QIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLL 253
+ + L+QNG + + K + L +A G+ ++ L G D + + PL
Sbjct: 293 RFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLH 352
Query: 254 YAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIES 302
A H C + LL SG + G + A A G ++++S
Sbjct: 353 LAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQS 401
Score = 46.2 bits (108), Expect = 4e-05
Identities = 36/151 (23%), Positives = 63/151 (41%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A G+ + I +N D TPL A A V+ L+++ AD
Sbjct: 20 LHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARD 79
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
K ++ L +A + ++++ VN D G T L +A HV+ V +LL GA
Sbjct: 80 KNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGA 139
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVIESH 303
+ ++ A +G+ V ++ +H
Sbjct: 140 NINAFDKKDRRALHWAAYMGHLDVVALLINH 170
Score = 45.4 bits (106), Expect = 6e-05
Identities = 33/125 (26%), Positives = 54/125 (43%)
Query: 169 IEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYT 228
I + +N D E TPL AA G ++E L+ +GA + L A +
Sbjct: 3 IHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSE 62
Query: 229 DIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLA 288
+ V++L+ DVN D N TPL A VKC ++++ + + G ++ A
Sbjct: 63 EAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHA 122
Query: 289 VALGY 293
G+
Sbjct: 123 ALNGH 127
Score = 45.4 bits (106), Expect = 6e-05
Identities = 33/114 (28%), Positives = 54/114 (47%), Gaps = 5/114 (4%)
Query: 184 TPLMWAAAHGQIAVVEFLLQNGADPQLL----GKGRESALSLACSKGYTDIVKMLLDCGV 239
TPL + +G + LL+ +P+ + KG ++ L LA + G+ D V +LL+
Sbjct: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKG-QTPLMLAVAYGHIDAVSLLLEKEA 669
Query: 240 DVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGY 293
+V+ D G T L + H +CV+MLLE + G + A A G+
Sbjct: 670 NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGH 723
Score = 44.7 bits (104), Expect = 1e-04
Identities = 27/105 (25%), Positives = 52/105 (49%), Gaps = 1/105 (0%)
Query: 173 NVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVK 232
++++ D++G TPL AA + ++ LL++ A + ++AL +A G V
Sbjct: 805 SIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVD 864
Query: 233 MLLDCG-VDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTI 276
+L++ D+ D + TPL A H KC ++L+ D ++
Sbjct: 865 ILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESL 909
Score = 43.1 bits (100), Expect = 3e-04
Identities = 33/94 (35%), Positives = 45/94 (47%), Gaps = 8/94 (8%)
Query: 144 TPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQ 203
TPL A + + H E L L R +N D G T LM AA +GQ V+ L+
Sbjct: 816 TPLRAAAFADHV-----ECLQLLLR--HSAPVNAVDNSGKTALMMAAENGQAGAVDILVN 868
Query: 204 NG-ADPQLLGKGRESALSLACSKGYTDIVKMLLD 236
+ AD + K + L LACSKG+ ++LD
Sbjct: 869 SAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 79.0 bits (193), Expect = 5e-15
Identities = 43/129 (33%), Positives = 70/129 (54%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
+N T ++G +PL AA HG+ ++ LL++GA+ + L LAC +G+ +VK L
Sbjct: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYR 294
LD N+ D +G TPL+YA G H + V +LL+ GA + G ++ AV +
Sbjct: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHV 856
Query: 295 SVQQVIESH 303
V +++ H
Sbjct: 857 FVVELLLLH 865
Score = 61.6 bits (148), Expect = 9e-10
Identities = 46/135 (34%), Positives = 61/135 (45%), Gaps = 10/135 (7%)
Query: 179 DEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCG 238
D+ G TPL AA GQ ++++ L+ GA + L LAC KGY + +LL
Sbjct: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYK 519
Query: 239 VDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADP---TIETDSGYNSMDLAVALGYRS 295
D NG TPL A H CVK L+ + I + G + +A GY
Sbjct: 520 ASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGY-- 577
Query: 296 VQQVIESHLLKLLQN 310
Q VIE+ LLQN
Sbjct: 578 -QGVIET----LLQN 587
Score = 53.1 bits (126), Expect = 3e-07
Identities = 37/130 (28%), Positives = 60/130 (46%), Gaps = 7/130 (5%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A G+ + + + ++N TD G TPL A G +V LL A ++
Sbjct: 467 LHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQD 526
Query: 213 KGRESALSLACSKGYTDIVKMLL-----DCGVDVNEYDWNGGTPLLYAVHGNHVKCVKML 267
+ L LAC+ G+ D VK L+ C +D+ + G TPL A + ++ L
Sbjct: 527 NNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIG--NEKGDTPLHIAARWGYQGVIETL 584
Query: 268 LESGADPTIE 277
L++GA I+
Sbjct: 585 LQNGASTEIQ 594
Score = 50.8 bits (120), Expect = 2e-06
Identities = 34/104 (32%), Positives = 48/104 (46%)
Query: 185 PLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEY 244
PL A G VV+ LL + A P + L ACS G+ ++V +LL G +N
Sbjct: 780 PLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINAS 839
Query: 245 DWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLA 288
+ G T L AV HV V++LL GA + ++D A
Sbjct: 840 NNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCA 883
Score = 40.0 bits (92), Expect = 0.003
Identities = 34/138 (24%), Positives = 59/138 (42%), Gaps = 7/138 (5%)
Query: 170 EQENVINHTDEEGFTPLMW----AAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSK 225
+ E+ ++ D E PL A A ++A V +G + + S L +A
Sbjct: 698 DAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVP---ASGLGVNVTSQDGSSPLHVAALH 754
Query: 226 GYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSM 285
G D++ +LL G + + + PL A H + VK LL+S A P + SG +
Sbjct: 755 GRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPL 814
Query: 286 DLAVALGYRSVQQVIESH 303
A + G+ + ++ H
Sbjct: 815 IYACSGGHHELVALLLQH 832
Score = 37.4 bits (85), Expect = 0.017
Identities = 25/92 (27%), Positives = 42/92 (45%)
Query: 150 SLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQ 209
++ +H QG + ++ N D G TPL++A + G +V LLQ+GA
Sbjct: 778 AVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASIN 837
Query: 210 LLGKGRESALSLACSKGYTDIVKMLLDCGVDV 241
+AL A + + +V++LL G V
Sbjct: 838 ASNNKGNTALHEAVIEKHVFVVELLLLHGASV 869
Score = 35.8 bits (81), Expect = 0.050
Identities = 19/54 (35%), Positives = 31/54 (57%)
Query: 179 DEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVK 232
+E+G TPL AA G V+E LLQNGA ++ + +E+ L A + +++
Sbjct: 562 NEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVME 615
Score = 34.3 bits (77), Expect = 0.15
Identities = 33/115 (28%), Positives = 56/115 (48%), Gaps = 12/115 (10%)
Query: 122 HFSPIKQSTTLTNKHRGNEVS-TTPLL-ANSLSVHQLAAQGEMLYLATRIEQENVINHTD 179
HF +K K ++S TPL+ A S H+L +A ++ IN ++
Sbjct: 789 HFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHEL--------VALLLQHGASINASN 840
Query: 180 EEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
+G T L A + VVE LL +GA Q+L K + +A+ C++ + I+++L
Sbjct: 841 NKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVD--CAEQNSKIMELL 893
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
sapiens]
Length = 2542
Score = 78.6 bits (192), Expect = 7e-15
Identities = 60/186 (32%), Positives = 94/186 (50%), Gaps = 11/186 (5%)
Query: 119 TTKHFSPIKQSTTLTNKHRGNEVSTTPLL---ANSLSVHQLA-----AQGEMLYLATRIE 170
TT+ +P S T +N + P + A++ S H A A G ++ I
Sbjct: 1017 TTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIA 1076
Query: 171 QENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG-KGRESALSLACSKGYTD 229
++ I H D++GFTPL+ AA G + VVE LL G D + + +++ LSLACS G +
Sbjct: 1077 RDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQE 1136
Query: 230 IVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDS--GYNSMDL 287
+V +LL G + + + TPL A G +V +K+LL +GA+ T S G + + L
Sbjct: 1137 VVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLML 1196
Query: 288 AVALGY 293
A G+
Sbjct: 1197 AAMNGH 1202
Score = 74.3 bits (181), Expect = 1e-13
Identities = 54/195 (27%), Positives = 89/195 (45%), Gaps = 25/195 (12%)
Query: 134 NKHRGNEVSTTPLLANSLSVHQ-----LAAQGEMLYLATRIEQENVINHTDEEGF----- 183
N N+ TPL+ + H+ L AQG + T QE + GF
Sbjct: 463 NLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVAD 522
Query: 184 --------------TPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTD 229
TPLM A+ G + +V++LL +GA+ ++AL+ AC G+TD
Sbjct: 523 FLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTD 582
Query: 230 IVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIET-DSGYNSMDLA 288
+ +LL G D+ G TPL+ A H+ V+ L+ GA+ T ++ + + LA
Sbjct: 583 VADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLA 642
Query: 289 VALGYRSVQQVIESH 303
A G+ +V +++ +H
Sbjct: 643 CAGGHLAVVELLLAH 657
Score = 72.0 bits (175), Expect = 6e-13
Identities = 37/100 (37%), Positives = 62/100 (62%)
Query: 173 NVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVK 232
NV + ++ TPLM A++ G + +V+ LL + AD +AL+ AC+ G+ DIVK
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 233 MLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+LL+ G ++ +++ NG TPL+ A HV+ ++LL+ GA
Sbjct: 323 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
Score = 72.0 bits (175), Expect = 6e-13
Identities = 47/145 (32%), Positives = 75/145 (51%), Gaps = 4/145 (2%)
Query: 157 AAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQL-LGKGR 215
A G + A IE+ + ++EG+TPLM AA G +V LL GA+ + +
Sbjct: 446 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505
Query: 216 ESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPT 275
E+AL+LAC G++++ L+ G D+ + TPL+ A H++ VK LL SGA+
Sbjct: 506 ETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVH 562
Query: 276 IETDSGYNSMDLAVALGYRSVQQVI 300
T +G ++ A G+ V V+
Sbjct: 563 ATTATGDTALTYACENGHTDVADVL 587
Score = 71.6 bits (174), Expect = 8e-13
Identities = 52/171 (30%), Positives = 81/171 (47%), Gaps = 8/171 (4%)
Query: 134 NKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHG 193
N H +V T S+ + + G++ + +++ +N EEG + L A + G
Sbjct: 197 NSHNAGQVDTR-------SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
Query: 194 QIAVVEFLLQNGADPQLLG-KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPL 252
+ + LL A+ + G KG + L A S GY DIVK+LL DVN G T L
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
Query: 253 LYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESH 303
YA G V VK+LL GA+ ++G+ + A + G+ V +V+ H
Sbjct: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Score = 65.9 bits (159), Expect = 5e-11
Identities = 37/117 (31%), Positives = 64/117 (54%), Gaps = 2/117 (1%)
Query: 159 QGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQL--LGKGRE 216
QG ++ ++++ + H + G TPLM AA+ G V LL GAD + R+
Sbjct: 1234 QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293
Query: 217 SALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGAD 273
+AL++A KG+ ++L+ G ++ + G TPL A +G H V++L+++GAD
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350
Score = 65.1 bits (157), Expect = 8e-11
Identities = 47/159 (29%), Positives = 75/159 (47%), Gaps = 8/159 (5%)
Query: 139 NEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVIN-HTDEEGFTPLMWAAAHGQIAV 197
NE TPL+ + A+ G + ++ IN H++E + L A G + +
Sbjct: 335 NENGHTPLM-------EAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
Query: 198 VEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVH 257
V FLL+ GAD + +AL AC G+ ++ ++LLD G VN + +PL A
Sbjct: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
Query: 258 GNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSV 296
G HV+ +L+E GA+ D GY + A G+ +
Sbjct: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM 486
Score = 63.2 bits (152), Expect = 3e-10
Identities = 35/93 (37%), Positives = 54/93 (58%), Gaps = 1/93 (1%)
Query: 182 GFTPLMWAAAHGQIAVVEFLLQNGADPQL-LGKGRESALSLACSKGYTDIVKMLLDCGVD 240
G +PLM AA +G + V+ LL G+D + R +AL+LAC +G ++V +LLD +
Sbjct: 1190 GISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKAN 1249
Query: 241 VNEYDWNGGTPLLYAVHGNHVKCVKMLLESGAD 273
V G TPL+ A G + + ++LL+ GAD
Sbjct: 1250 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1282
Score = 61.2 bits (147), Expect = 1e-09
Identities = 45/165 (27%), Positives = 81/165 (49%), Gaps = 8/165 (4%)
Query: 137 RGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIA 196
RGN+ TPL+A S + G + + + + +N G T L +A A G +
Sbjct: 267 RGNKGDITPLMAAS-------SGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD 319
Query: 197 VVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWN-GGTPLLYA 255
+V+ LL GA+ + + + L A S G+ ++ ++LLD G +N + + L A
Sbjct: 320 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 379
Query: 256 VHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
+ H+ V+ LLE+GAD +TD + ++ A G+ V +++
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Score = 61.2 bits (147), Expect = 1e-09
Identities = 37/121 (30%), Positives = 61/121 (50%), Gaps = 1/121 (0%)
Query: 177 HTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLD 236
H +E T LM A G + V LL +GA + ES L+LA G+ ++ +L++
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
Query: 237 CGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIET-DSGYNSMDLAVALGYRS 295
G ++ E + G TPL+ A H + V +LL GA+ +T ++ ++ LA G+
Sbjct: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSE 519
Query: 296 V 296
V
Sbjct: 520 V 520
Score = 60.5 bits (145), Expect = 2e-09
Identities = 44/136 (32%), Positives = 64/136 (47%), Gaps = 12/136 (8%)
Query: 146 LLANSLSVHQLAAQGEM-LYLATRIEQENV----------INHTDEEGFTPLMWAAAHGQ 194
LLA+ +VH A G+ L A +V + H E G TPLM AA G
Sbjct: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 613
Query: 195 IAVVEFLLQNGADP-QLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLL 253
+ V+FL+ GA+ + + +SLAC+ G+ +V++LL G D +G T L+
Sbjct: 614 LCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLI 673
Query: 254 YAVHGNHVKCVKMLLE 269
A G H V LL+
Sbjct: 674 EAAKGGHTNVVSYLLD 689
Score = 52.4 bits (124), Expect = 5e-07
Identities = 37/125 (29%), Positives = 60/125 (48%), Gaps = 1/125 (0%)
Query: 177 HTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLD 236
HT+ T L A A G +V L+ A + K + L LA + G+ +V++LLD
Sbjct: 1050 HTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD 1109
Query: 237 CGVDVN-EYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRS 295
G D+ + + TPL A G + V +LL GA+ S Y + LA + GY +
Sbjct: 1110 KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVN 1169
Query: 296 VQQVI 300
+ +++
Sbjct: 1170 IIKIL 1174
Score = 50.1 bits (118), Expect = 3e-06
Identities = 45/169 (26%), Positives = 75/169 (44%), Gaps = 8/169 (4%)
Query: 134 NKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHG 193
N G+++ +PL+ +++ H A + +L + + I + N T L A G
Sbjct: 1182 NSRTGSKLGISPLMLAAMNGHVPAVK-LLLDMGSDINAQIETNRN-----TALTLACFQG 1235
Query: 194 QIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVN--EYDWNGGTP 251
+ VV LL A+ + K + L A S GY ++ ++LLD G DVN + T
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
Query: 252 LLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
L A H K ++L+ GA + G + LA G+ V Q++
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Score = 43.9 bits (102), Expect = 2e-04
Identities = 40/149 (26%), Positives = 63/149 (42%), Gaps = 7/149 (4%)
Query: 88 LEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLL 147
LE+ L + N+H + + G + + + +H +E TPL+
Sbjct: 548 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE-SEGGRTPLM 606
Query: 148 ANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
+ + H Q +L ++ NV T T + A A G +AVVE LL +GAD
Sbjct: 607 KAARAGHLCTVQ----FLISK--GANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD 660
Query: 208 PQLLGKGRESALSLACSKGYTDIVKMLLD 236
P K + L A G+T++V LLD
Sbjct: 661 PTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 38.5 bits (88), Expect = 0.008
Identities = 29/109 (26%), Positives = 56/109 (51%), Gaps = 4/109 (3%)
Query: 137 RGNEVSTTPLLANSLSVHQLAA-QGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQI 195
+G +V+ P+ ++ + +AA +G + I + I+ +++G TPL A+ G
Sbjct: 1279 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHF 1338
Query: 196 AVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEY 244
VV+ L+Q GAD + + L A KG+ +V+ L+ +VN++
Sbjct: 1339 DVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK---EVNQF 1384
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 78.6 bits (192), Expect = 7e-15
Identities = 60/186 (32%), Positives = 94/186 (50%), Gaps = 11/186 (5%)
Query: 119 TTKHFSPIKQSTTLTNKHRGNEVSTTPLL---ANSLSVHQLA-----AQGEMLYLATRIE 170
TT+ +P S T +N + P + A++ S H A A G ++ I
Sbjct: 1017 TTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIA 1076
Query: 171 QENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG-KGRESALSLACSKGYTD 229
++ I H D++GFTPL+ AA G + VVE LL G D + + +++ LSLACS G +
Sbjct: 1077 RDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQE 1136
Query: 230 IVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDS--GYNSMDL 287
+V +LL G + + + TPL A G +V +K+LL +GA+ T S G + + L
Sbjct: 1137 VVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLML 1196
Query: 288 AVALGY 293
A G+
Sbjct: 1197 AAMNGH 1202
Score = 74.3 bits (181), Expect = 1e-13
Identities = 54/195 (27%), Positives = 89/195 (45%), Gaps = 25/195 (12%)
Query: 134 NKHRGNEVSTTPLLANSLSVHQ-----LAAQGEMLYLATRIEQENVINHTDEEGF----- 183
N N+ TPL+ + H+ L AQG + T QE + GF
Sbjct: 463 NLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVAD 522
Query: 184 --------------TPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTD 229
TPLM A+ G + +V++LL +GA+ ++AL+ AC G+TD
Sbjct: 523 FLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTD 582
Query: 230 IVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIET-DSGYNSMDLA 288
+ +LL G D+ G TPL+ A H+ V+ L+ GA+ T ++ + + LA
Sbjct: 583 VADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLA 642
Query: 289 VALGYRSVQQVIESH 303
A G+ +V +++ +H
Sbjct: 643 CAGGHLAVVELLLAH 657
Score = 72.0 bits (175), Expect = 6e-13
Identities = 37/100 (37%), Positives = 62/100 (62%)
Query: 173 NVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVK 232
NV + ++ TPLM A++ G + +V+ LL + AD +AL+ AC+ G+ DIVK
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 233 MLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+LL+ G ++ +++ NG TPL+ A HV+ ++LL+ GA
Sbjct: 323 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
Score = 72.0 bits (175), Expect = 6e-13
Identities = 47/145 (32%), Positives = 75/145 (51%), Gaps = 4/145 (2%)
Query: 157 AAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQL-LGKGR 215
A G + A IE+ + ++EG+TPLM AA G +V LL GA+ + +
Sbjct: 446 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505
Query: 216 ESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPT 275
E+AL+LAC G++++ L+ G D+ + TPL+ A H++ VK LL SGA+
Sbjct: 506 ETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVH 562
Query: 276 IETDSGYNSMDLAVALGYRSVQQVI 300
T +G ++ A G+ V V+
Sbjct: 563 ATTATGDTALTYACENGHTDVADVL 587
Score = 71.6 bits (174), Expect = 8e-13
Identities = 52/171 (30%), Positives = 81/171 (47%), Gaps = 8/171 (4%)
Query: 134 NKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHG 193
N H +V T S+ + + G++ + +++ +N EEG + L A + G
Sbjct: 197 NSHNAGQVDTR-------SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
Query: 194 QIAVVEFLLQNGADPQLLG-KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPL 252
+ + LL A+ + G KG + L A S GY DIVK+LL DVN G T L
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
Query: 253 LYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESH 303
YA G V VK+LL GA+ ++G+ + A + G+ V +V+ H
Sbjct: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Score = 65.9 bits (159), Expect = 5e-11
Identities = 37/117 (31%), Positives = 64/117 (54%), Gaps = 2/117 (1%)
Query: 159 QGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQL--LGKGRE 216
QG ++ ++++ + H + G TPLM AA+ G V LL GAD + R+
Sbjct: 1234 QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293
Query: 217 SALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGAD 273
+AL++A KG+ ++L+ G ++ + G TPL A +G H V++L+++GAD
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350
Score = 65.1 bits (157), Expect = 8e-11
Identities = 47/159 (29%), Positives = 75/159 (47%), Gaps = 8/159 (5%)
Query: 139 NEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVIN-HTDEEGFTPLMWAAAHGQIAV 197
NE TPL+ + A+ G + ++ IN H++E + L A G + +
Sbjct: 335 NENGHTPLM-------EAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
Query: 198 VEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVH 257
V FLL+ GAD + +AL AC G+ ++ ++LLD G VN + +PL A
Sbjct: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
Query: 258 GNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSV 296
G HV+ +L+E GA+ D GY + A G+ +
Sbjct: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM 486
Score = 63.2 bits (152), Expect = 3e-10
Identities = 35/93 (37%), Positives = 54/93 (58%), Gaps = 1/93 (1%)
Query: 182 GFTPLMWAAAHGQIAVVEFLLQNGADPQL-LGKGRESALSLACSKGYTDIVKMLLDCGVD 240
G +PLM AA +G + V+ LL G+D + R +AL+LAC +G ++V +LLD +
Sbjct: 1190 GISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKAN 1249
Query: 241 VNEYDWNGGTPLLYAVHGNHVKCVKMLLESGAD 273
V G TPL+ A G + + ++LL+ GAD
Sbjct: 1250 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1282
Score = 61.2 bits (147), Expect = 1e-09
Identities = 45/165 (27%), Positives = 81/165 (49%), Gaps = 8/165 (4%)
Query: 137 RGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIA 196
RGN+ TPL+A S + G + + + + +N G T L +A A G +
Sbjct: 267 RGNKGDITPLMAAS-------SGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD 319
Query: 197 VVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWN-GGTPLLYA 255
+V+ LL GA+ + + + L A S G+ ++ ++LLD G +N + + L A
Sbjct: 320 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 379
Query: 256 VHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
+ H+ V+ LLE+GAD +TD + ++ A G+ V +++
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Score = 61.2 bits (147), Expect = 1e-09
Identities = 37/121 (30%), Positives = 61/121 (50%), Gaps = 1/121 (0%)
Query: 177 HTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLD 236
H +E T LM A G + V LL +GA + ES L+LA G+ ++ +L++
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
Query: 237 CGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIET-DSGYNSMDLAVALGYRS 295
G ++ E + G TPL+ A H + V +LL GA+ +T ++ ++ LA G+
Sbjct: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSE 519
Query: 296 V 296
V
Sbjct: 520 V 520
Score = 60.5 bits (145), Expect = 2e-09
Identities = 44/136 (32%), Positives = 64/136 (47%), Gaps = 12/136 (8%)
Query: 146 LLANSLSVHQLAAQGEM-LYLATRIEQENV----------INHTDEEGFTPLMWAAAHGQ 194
LLA+ +VH A G+ L A +V + H E G TPLM AA G
Sbjct: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 613
Query: 195 IAVVEFLLQNGADP-QLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLL 253
+ V+FL+ GA+ + + +SLAC+ G+ +V++LL G D +G T L+
Sbjct: 614 LCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLI 673
Query: 254 YAVHGNHVKCVKMLLE 269
A G H V LL+
Sbjct: 674 EAAKGGHTNVVSYLLD 689
Score = 52.4 bits (124), Expect = 5e-07
Identities = 37/125 (29%), Positives = 60/125 (48%), Gaps = 1/125 (0%)
Query: 177 HTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLD 236
HT+ T L A A G +V L+ A + K + L LA + G+ +V++LLD
Sbjct: 1050 HTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD 1109
Query: 237 CGVDVN-EYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRS 295
G D+ + + TPL A G + V +LL GA+ S Y + LA + GY +
Sbjct: 1110 KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVN 1169
Query: 296 VQQVI 300
+ +++
Sbjct: 1170 IIKIL 1174
Score = 50.1 bits (118), Expect = 3e-06
Identities = 45/169 (26%), Positives = 75/169 (44%), Gaps = 8/169 (4%)
Query: 134 NKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHG 193
N G+++ +PL+ +++ H A + +L + + I + N T L A G
Sbjct: 1182 NSRTGSKLGISPLMLAAMNGHVPAVK-LLLDMGSDINAQIETNRN-----TALTLACFQG 1235
Query: 194 QIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVN--EYDWNGGTP 251
+ VV LL A+ + K + L A S GY ++ ++LLD G DVN + T
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
Query: 252 LLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
L A H K ++L+ GA + G + LA G+ V Q++
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Score = 43.9 bits (102), Expect = 2e-04
Identities = 40/149 (26%), Positives = 63/149 (42%), Gaps = 7/149 (4%)
Query: 88 LEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLL 147
LE+ L + N+H + + G + + + +H +E TPL+
Sbjct: 548 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE-SEGGRTPLM 606
Query: 148 ANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
+ + H Q +L ++ NV T T + A A G +AVVE LL +GAD
Sbjct: 607 KAARAGHLCTVQ----FLISK--GANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD 660
Query: 208 PQLLGKGRESALSLACSKGYTDIVKMLLD 236
P K + L A G+T++V LLD
Sbjct: 661 PTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 38.5 bits (88), Expect = 0.008
Identities = 29/109 (26%), Positives = 56/109 (51%), Gaps = 4/109 (3%)
Query: 137 RGNEVSTTPLLANSLSVHQLAA-QGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQI 195
+G +V+ P+ ++ + +AA +G + I + I+ +++G TPL A+ G
Sbjct: 1279 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHF 1338
Query: 196 AVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEY 244
VV+ L+Q GAD + + L A KG+ +V+ L+ +VN++
Sbjct: 1339 DVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK---EVNQF 1384
>gi|62420875 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 78.2 bits (191), Expect = 9e-15
Identities = 47/140 (33%), Positives = 75/140 (53%), Gaps = 4/140 (2%)
Query: 172 ENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIV 231
EN +N D+ GF+PL WA G+ AVVE L+ GA ++ +G ++ L LA S G+ DIV
Sbjct: 24 ENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIV 83
Query: 232 KMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVAL 291
+ LL D+N + +G PL YA + + L+ +GA +I G +D A A
Sbjct: 84 QKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKA- 142
Query: 292 GYRSVQQVIESHLLKLLQNI 311
+++++ K+ QN+
Sbjct: 143 ---PLRELLRERAEKMGQNL 159
Score = 31.2 bits (69), Expect = 1.2
Identities = 21/70 (30%), Positives = 32/70 (45%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A+ G + ++ + IN +E G PL +A GQ V E L+ NGA +
Sbjct: 71 LHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICN 130
Query: 213 KGRESALSLA 222
K E + A
Sbjct: 131 KYGEMPVDKA 140
>gi|62420873 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 78.2 bits (191), Expect = 9e-15
Identities = 47/140 (33%), Positives = 75/140 (53%), Gaps = 4/140 (2%)
Query: 172 ENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIV 231
EN +N D+ GF+PL WA G+ AVVE L+ GA ++ +G ++ L LA S G+ DIV
Sbjct: 24 ENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIV 83
Query: 232 KMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVAL 291
+ LL D+N + +G PL YA + + L+ +GA +I G +D A A
Sbjct: 84 QKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKA- 142
Query: 292 GYRSVQQVIESHLLKLLQNI 311
+++++ K+ QN+
Sbjct: 143 ---PLRELLRERAEKMGQNL 159
Score = 31.2 bits (69), Expect = 1.2
Identities = 21/70 (30%), Positives = 32/70 (45%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A+ G + ++ + IN +E G PL +A GQ V E L+ NGA +
Sbjct: 71 LHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICN 130
Query: 213 KGRESALSLA 222
K E + A
Sbjct: 131 KYGEMPVDKA 140
>gi|4758606 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 78.2 bits (191), Expect = 9e-15
Identities = 47/140 (33%), Positives = 75/140 (53%), Gaps = 4/140 (2%)
Query: 172 ENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIV 231
EN +N D+ GF+PL WA G+ AVVE L+ GA ++ +G ++ L LA S G+ DIV
Sbjct: 24 ENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIV 83
Query: 232 KMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVAL 291
+ LL D+N + +G PL YA + + L+ +GA +I G +D A A
Sbjct: 84 QKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKA- 142
Query: 292 GYRSVQQVIESHLLKLLQNI 311
+++++ K+ QN+
Sbjct: 143 ---PLRELLRERAEKMGQNL 159
Score = 31.2 bits (69), Expect = 1.2
Identities = 21/70 (30%), Positives = 32/70 (45%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A+ G + ++ + IN +E G PL +A GQ V E L+ NGA +
Sbjct: 71 LHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICN 130
Query: 213 KGRESALSLA 222
K E + A
Sbjct: 131 KYGEMPVDKA 140
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 78.2 bits (191), Expect = 9e-15
Identities = 46/150 (30%), Positives = 80/150 (53%), Gaps = 2/150 (1%)
Query: 153 VHQLAAQGEMLYLATRIE--QENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQL 210
+H A +G + LA +E ++ ++H D+ G T AA HGQ+ ++FL+ +G D +
Sbjct: 128 LHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNV 187
Query: 211 LGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLES 270
K +AL LA +G+ +++ L+D G+D+ E + G T L A G+H CV++LL +
Sbjct: 188 KDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRA 247
Query: 271 GADPTIETDSGYNSMDLAVALGYRSVQQVI 300
G+ T + + A G V +V+
Sbjct: 248 GSTVNALTQKNLSCLHYAALSGSEDVSRVL 277
Score = 64.3 bits (155), Expect = 1e-10
Identities = 48/161 (29%), Positives = 70/161 (43%), Gaps = 2/161 (1%)
Query: 149 NSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADP 208
N +H A G I N D +G +PL A H A+V L+ + +D
Sbjct: 258 NLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDV 317
Query: 209 QLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLL 268
+ +++ L LA + DI MLL GVD+N D G T L AV NHV V M++
Sbjct: 318 NAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
Query: 269 ESGADPTIETD--SGYNSMDLAVALGYRSVQQVIESHLLKL 307
++ E D S + L+ +R Q + S L +L
Sbjct: 378 KADRFYRWEKDHPSDPSGKSLSFKQDHRQETQQLRSVLWRL 418
Score = 52.8 bits (125), Expect = 4e-07
Identities = 37/149 (24%), Positives = 64/149 (42%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
++H A +G M L ++ + + EG T L AA V+ LL+ G+ L
Sbjct: 195 ALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNAL 254
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESG 271
+ S L A G D+ ++L+ G N D G +PL AV N V++L+ S
Sbjct: 255 TQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSD 314
Query: 272 ADPTIETDSGYNSMDLAVALGYRSVQQVI 300
+D + + LA ++ + ++
Sbjct: 315 SDVNAVDNRQQTPLHLAAEHAWQDIADML 343
Score = 45.4 bits (106), Expect = 6e-05
Identities = 37/147 (25%), Positives = 65/147 (44%)
Query: 154 HQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGK 213
H+ A G++ L + N D+EG T L AA G +AV++ L+ G D +
Sbjct: 164 HRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNA 223
Query: 214 GRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGAD 273
+AL A + D V++LL G VN + L YA ++L+ +G
Sbjct: 224 EGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGC 283
Query: 274 PTIETDSGYNSMDLAVALGYRSVQQVI 300
+ G + + LAV + ++ +++
Sbjct: 284 ANVVDHQGASPLHLAVRHNFPALVRLL 310
Score = 42.7 bits (99), Expect = 4e-04
Identities = 34/160 (21%), Positives = 66/160 (41%), Gaps = 12/160 (7%)
Query: 151 LSVHQLAAQGEMLYLATRIEQENVINHTDEEG----------FTPLMWAAAHGQIAVVEF 200
+++H A G + +E E ++ D G L+ +A G + +++
Sbjct: 50 VALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQI 109
Query: 201 LLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDV--NEYDWNGGTPLLYAVHG 258
L+ +GA K + L A KG+ ++ +++ DV + D G T A
Sbjct: 110 LVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEH 169
Query: 259 NHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQ 298
+ + L+ SG D ++ G ++ LA G+ +V Q
Sbjct: 170 GQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQ 209
Score = 42.7 bits (99), Expect = 4e-04
Identities = 32/128 (25%), Positives = 55/128 (42%)
Query: 173 NVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVK 232
+ +N ++ + L +AA G V L+ G ++ S L LA + +V+
Sbjct: 249 STVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVR 308
Query: 233 MLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALG 292
+L++ DVN D TPL A MLL +G D + G ++ +AV
Sbjct: 309 LLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSN 368
Query: 293 YRSVQQVI 300
+ S+ +I
Sbjct: 369 HVSLVDMI 376
Score = 28.9 bits (63), Expect = 6.2
Identities = 25/97 (25%), Positives = 40/97 (41%), Gaps = 10/97 (10%)
Query: 218 ALSLACSKGYTDIVKMLLDCGVDVNEYDWNGG----------TPLLYAVHGNHVKCVKML 267
AL A G+ V++LL+ V+E D G LL + H++ +++L
Sbjct: 51 ALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQIL 110
Query: 268 LESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHL 304
+ SGA E+ G + A G+ V I L
Sbjct: 111 VNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDL 147
>gi|148596917 fibronectin type III and ankyrin repeat domains 1
[Homo sapiens]
Length = 345
Score = 77.8 bits (190), Expect = 1e-14
Identities = 41/130 (31%), Positives = 73/130 (56%), Gaps = 2/130 (1%)
Query: 179 DEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL--GKGRESALSLACSKGYTDIVKMLLD 236
D G T L WAA G +V+E+++++G + ++ G G + ++ G + +L+D
Sbjct: 207 DLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLID 266
Query: 237 CGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSV 296
G +VN D NG TPL+ AV NH + V++LL+ GAD +++ + G +++A +SV
Sbjct: 267 AGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSV 326
Query: 297 QQVIESHLLK 306
++E K
Sbjct: 327 VSLLEERKKK 336
Score = 65.5 bits (158), Expect = 6e-11
Identities = 51/189 (26%), Positives = 83/189 (43%), Gaps = 19/189 (10%)
Query: 114 VYTPSTTKHFSPIKQSTTLTN-----KHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATR 168
+YT TKH + TL E +PL+ S+S + E L+ A
Sbjct: 62 IYTGYATKHVVEGLEPRTLYRFRLKVTSPSGECEYSPLV--SVSTTREPISSEHLHRAVS 119
Query: 169 IEQENV-----------INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRES 217
+ E++ ++ ++ GFT LM AA G +V+ L+ NG D L +
Sbjct: 120 VNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKD 179
Query: 218 ALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGAD-PTI 276
+L LAC G+ D+VK L G D G T L +A G H ++ +++ G + +
Sbjct: 180 SLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVV 239
Query: 277 ETDSGYNSM 285
+T SG+ +
Sbjct: 240 DTGSGWTPL 248
Score = 45.8 bits (107), Expect = 5e-05
Identities = 28/80 (35%), Positives = 41/80 (51%)
Query: 217 SALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTI 276
+AL +A KGYT +VK+L+ G DVN + +G L+ A + H+ VK L GA
Sbjct: 146 TALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQA 205
Query: 277 ETDSGYNSMDLAVALGYRSV 296
G ++ A G+ SV
Sbjct: 206 RDLGGCTALHWAADGGHCSV 225
Score = 32.3 bits (72), Expect = 0.56
Identities = 25/91 (27%), Positives = 38/91 (41%), Gaps = 6/91 (6%)
Query: 144 TPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQ 203
TPL+ S A G + I+ +N D G TPLM A + +V+ LL
Sbjct: 246 TPLMRVS------AVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLD 299
Query: 204 NGADPQLLGKGRESALSLACSKGYTDIVKML 234
GAD + + + L +A +V +L
Sbjct: 300 KGADASVKNEFGKGVLEMARVFDRQSVVSLL 330
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 77.8 bits (190), Expect = 1e-14
Identities = 48/127 (37%), Positives = 70/127 (55%), Gaps = 5/127 (3%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLAC-----SKGYTD 229
+N D EG T L+ AA G +VE LL +GA+ +ALS+A SKG+
Sbjct: 670 VNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHAS 729
Query: 230 IVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAV 289
+V +L+D G +V+ D +G TPLL A + HV V +LLE GAD ++G + A
Sbjct: 730 VVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAA 789
Query: 290 ALGYRSV 296
++G+ SV
Sbjct: 790 SMGHASV 796
Score = 76.6 bits (187), Expect = 3e-14
Identities = 44/144 (30%), Positives = 74/144 (51%)
Query: 157 AAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRE 216
A++G ++ I++ ++H D++G TPL+ AA G + VV+ LL+ GAD
Sbjct: 723 ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR 782
Query: 217 SALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTI 276
+ L A S G+ +V LL G V+ D G T L A +V+ V+ LL+ G D
Sbjct: 783 TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842
Query: 277 ETDSGYNSMDLAVALGYRSVQQVI 300
D+G+ + +A G+R + + +
Sbjct: 843 RDDAGWTPLHMAAFEGHRLICEAL 866
Score = 68.2 bits (165), Expect = 9e-12
Identities = 47/160 (29%), Positives = 76/160 (47%), Gaps = 7/160 (4%)
Query: 144 TPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQ 203
TPLLA A+ G + T + ++ D EG T L A+A G + VV LL
Sbjct: 783 TPLLA-------AASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLD 835
Query: 204 NGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKC 263
G D + L +A +G+ I + L++ G NE D +G P + A H C
Sbjct: 836 RGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDC 895
Query: 264 VKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESH 303
V++LLE+ ++ G N++ +A G+R + +++ SH
Sbjct: 896 VQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSH 935
Score = 66.6 bits (161), Expect = 3e-11
Identities = 50/157 (31%), Positives = 74/157 (47%), Gaps = 7/157 (4%)
Query: 144 TPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQ 203
TPLL A +G + + +E ++HTD G TPL+ AA+ G +VV LL
Sbjct: 750 TPLLV-------AAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLF 802
Query: 204 NGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKC 263
GA + + LS+A ++G ++V+ LLD G+D N D G TPL A H
Sbjct: 803 WGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLI 862
Query: 264 VKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
+ L+E GA + G LA G+ Q++
Sbjct: 863 CEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 899
Score = 66.2 bits (160), Expect = 3e-11
Identities = 48/169 (28%), Positives = 76/169 (44%), Gaps = 8/169 (4%)
Query: 132 LTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAA 191
L HR ++ TPL H A +G L IEQ N D +G P + A+
Sbjct: 838 LDENHR-DDAGWTPL-------HMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQ 889
Query: 192 HGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTP 251
G V+ LL+N ++ G +AL +A +G+ DIV++L G DVN D +G
Sbjct: 890 EGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPT 949
Query: 252 LLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
L N + + LE+GA+ G ++ ++ G+ + QV+
Sbjct: 950 LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
Score = 65.5 bits (158), Expect = 6e-11
Identities = 42/114 (36%), Positives = 58/114 (50%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
INHTD++G+T L AA G VV LL G +AL A G+ DIV L
Sbjct: 604 INHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNL 663
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLA 288
L G +VN+ D G T L+ A + H + V+ LL+ GA+ E G ++ +A
Sbjct: 664 LQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717
Score = 64.7 bits (156), Expect = 1e-10
Identities = 36/107 (33%), Positives = 55/107 (51%)
Query: 165 LATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACS 224
+ T ++ +N D G T L AA G + VV L+ GAD ++ + L+LA
Sbjct: 528 IRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAAR 587
Query: 225 KGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESG 271
+G+T +V L+ CG ++N D +G T L A G H + V LL +G
Sbjct: 588 QGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAG 634
Score = 64.7 bits (156), Expect = 1e-10
Identities = 40/152 (26%), Positives = 74/152 (48%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
+++ LA + ++ +E + +D EG T L + G + +V+ L+ AD
Sbjct: 949 TLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAA 1008
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESG 271
+ SAL A +G+ +V++L++ G V+ G T L A H+ V++LLE G
Sbjct: 1009 DNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG 1068
Query: 272 ADPTIETDSGYNSMDLAVALGYRSVQQVIESH 303
ADP G +M +A G+ + +++E +
Sbjct: 1069 ADPNHADQFGRTAMRVAAKNGHSQIIKLLEKY 1100
Score = 62.8 bits (151), Expect = 4e-10
Identities = 38/129 (29%), Positives = 66/129 (51%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
+N D +G L A Q+ + E+ L+NGA+ + +AL ++C +G+ ++V++L
Sbjct: 939 VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYR 294
+ DVN D + L A HVK V++L+E GA + G ++ +A G+
Sbjct: 999 IAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHI 1058
Query: 295 SVQQVIESH 303
V QV+ H
Sbjct: 1059 DVVQVLLEH 1067
Score = 60.1 bits (144), Expect = 2e-09
Identities = 37/121 (30%), Positives = 60/121 (49%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
++H QG M + I +N D E + L AA G + VV+ L+++GA
Sbjct: 982 ALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHT 1041
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESG 271
+AL +A +G+ D+V++LL+ G D N D G T + A H + +K+L + G
Sbjct: 1042 CNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG 1101
Query: 272 A 272
A
Sbjct: 1102 A 1102
Score = 59.7 bits (143), Expect = 3e-09
Identities = 53/175 (30%), Positives = 76/175 (43%), Gaps = 11/175 (6%)
Query: 140 EVSTTPLLANSLSVHQLAAQGEMLYL-ATRIEQENVINHT----------DEEGFTPLMW 188
E S LL N SV+Q + G L A +V+N D G TPL
Sbjct: 525 EDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTL 584
Query: 189 AAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNG 248
AA G VV L+ GA+ + +AL A G+T++V LL GV V+ D +
Sbjct: 585 AARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 644
Query: 249 GTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESH 303
T L A G H V LL+ GA+ + G ++ A +G+R + + + H
Sbjct: 645 RTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDH 699
Score = 57.0 bits (136), Expect = 2e-08
Identities = 35/125 (28%), Positives = 61/125 (48%)
Query: 157 AAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRE 216
+AQG + + T +++ NH D+ G+TPL AA G + E L++ GA +
Sbjct: 822 SAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGR 881
Query: 217 SALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTI 276
LA +G+ D V++LL+ ++++ ++G L A H V++L GAD
Sbjct: 882 IPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNC 941
Query: 277 ETDSG 281
+ G
Sbjct: 942 KDADG 946
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 77.4 bits (189), Expect = 2e-14
Identities = 47/122 (38%), Positives = 65/122 (53%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
+N D++G TPLM AA+ G + V+FLL GA L+ K +ALS AC KG+ +V+ L
Sbjct: 1093 VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSL 1152
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYR 294
+D G + D NG TPL A + V+ L++ GA SG +D AV
Sbjct: 1153 VDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNT 1212
Query: 295 SV 296
SV
Sbjct: 1213 SV 1214
Score = 63.2 bits (152), Expect = 3e-10
Identities = 41/147 (27%), Positives = 65/147 (44%)
Query: 157 AAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRE 216
A +G++ +EQ + + G PL G +V+ LL +GAD + K
Sbjct: 1042 AGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGR 1101
Query: 217 SALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTI 276
+ L +A S+G+ V LL G + D G T L +A H+ V+ L+++GA
Sbjct: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161
Query: 277 ETDSGYNSMDLAVALGYRSVQQVIESH 303
+G +DLA G V Q + H
Sbjct: 1162 ADKNGRTPLDLAAFYGDAEVVQFLVDH 1188
Score = 60.1 bits (144), Expect = 2e-09
Identities = 38/116 (32%), Positives = 57/116 (49%)
Query: 157 AAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRE 216
A++G + + + Q I D+EG T L WA G ++VV L+ NGA K
Sbjct: 1108 ASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGR 1167
Query: 217 SALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+ L LA G ++V+ L+D G + D++G PL AV + V LL+ GA
Sbjct: 1168 TPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
Score = 48.9 bits (115), Expect = 6e-06
Identities = 45/167 (26%), Positives = 73/167 (43%), Gaps = 23/167 (13%)
Query: 157 AAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGR- 215
AA G + + ++ ++H D+ G L+ AA G + VV+FL+Q D + G+ +
Sbjct: 926 AAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQ--CDWTMAGQQQG 983
Query: 216 --------ESALSLACSKGYTDIVKMLLDC---------GVDVNEYD--WNGGTPLLYAV 256
+ AL A S GYT+IV LLD +N +D W G T L A
Sbjct: 984 VFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLW-GETALTAAA 1042
Query: 257 HGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESH 303
++ ++LLE GA G + V G+ + ++ +H
Sbjct: 1043 GRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTH 1089
Score = 43.9 bits (102), Expect = 2e-04
Identities = 22/63 (34%), Positives = 36/63 (57%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
++ + E G TPL +AAA G +++V L + A L K + AL A +G+ ++VK L
Sbjct: 911 VDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFL 970
Query: 235 LDC 237
+ C
Sbjct: 971 IQC 973
Score = 43.1 bits (100), Expect = 3e-04
Identities = 23/78 (29%), Positives = 40/78 (51%)
Query: 216 ESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPT 275
E+AL+ A +G ++ ++LL+ G V + + G PL V H + V +LL GAD
Sbjct: 1035 ETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVN 1094
Query: 276 IETDSGYNSMDLAVALGY 293
+ G + +A + G+
Sbjct: 1095 MADKQGRTPLMMAASEGH 1112
Score = 40.8 bits (94), Expect = 0.002
Identities = 27/98 (27%), Positives = 46/98 (46%), Gaps = 1/98 (1%)
Query: 173 NVINHTDEEGFTPLMWAAAH-GQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIV 231
N+ T+ P++ +H G +V LL+ GA+ + + L A + GY IV
Sbjct: 875 NINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIV 934
Query: 232 KMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLE 269
+L V+ D NG L++A H++ VK L++
Sbjct: 935 VLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQ 972
Score = 33.9 bits (76), Expect = 0.19
Identities = 17/47 (36%), Positives = 28/47 (59%)
Query: 226 GYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
GYT++V +LL+ G +V+ +G TPL YA ++ V +L + A
Sbjct: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRA 942
Score = 30.0 bits (66), Expect = 2.8
Identities = 16/50 (32%), Positives = 24/50 (48%)
Query: 247 NGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSV 296
N L H + + V +LLE GA+ ++SG + A A GY S+
Sbjct: 884 NNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSI 933
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 76.6 bits (187), Expect = 3e-14
Identities = 55/218 (25%), Positives = 103/218 (47%), Gaps = 12/218 (5%)
Query: 85 NSDLEVASVLFKAECNIHTSPSPGIQVRHVYTP-STTKHFSPIKQSTTLTNKHRGNEVST 143
N D A+VL + P+P + + +TP H+ + + L N RG V+
Sbjct: 216 NDDTRTAAVL------LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN--RGASVNF 267
Query: 144 TPLLANSLS-VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLL 202
TP N ++ +H + +G ++ + +++ I ++ TPL AA +G + + E LL
Sbjct: 268 TP--QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 325
Query: 203 QNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVK 262
+GA Q K S + +A + D V++LL ++++ + TPL A H H +
Sbjct: 326 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 385
Query: 263 CVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
K+LL+ GA P +G+ + +A + V +++
Sbjct: 386 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 423
Score = 76.3 bits (186), Expect = 3e-14
Identities = 49/155 (31%), Positives = 74/155 (47%)
Query: 148 ANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
A +H A +G + + +E+E ++GFTPL AA +G++ V E LL+ A
Sbjct: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 594
Query: 208 PQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKML 267
P GK + L +A DIVK+LL G + WNG TPL A N V+ + L
Sbjct: 595 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 654
Query: 268 LESGADPTIETDSGYNSMDLAVALGYRSVQQVIES 302
L+ G E+ G + LA G+ + ++ S
Sbjct: 655 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 689
Score = 71.6 bits (174), Expect = 8e-13
Identities = 41/119 (34%), Positives = 62/119 (52%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
I+ E G TPL A+ G + +V+ LLQ GA P + E+ L +A G+T++ K L
Sbjct: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGY 293
L VN + TPL A H VK+LLE+ A+P + T +G+ + +A G+
Sbjct: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 548
Score = 68.2 bits (165), Expect = 9e-12
Identities = 38/122 (31%), Positives = 64/122 (52%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
IN ++ G L A+ G + +V LL + K +AL +A G ++V+ L
Sbjct: 71 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 130
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYR 294
++ G +VN G TPL A NH++ VK LLE+GA+ + T+ G+ + +A+ G+
Sbjct: 131 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 190
Query: 295 SV 296
+V
Sbjct: 191 NV 192
Score = 65.1 bits (157), Expect = 8e-11
Identities = 47/166 (28%), Positives = 75/166 (45%), Gaps = 1/166 (0%)
Query: 149 NSLSVHQLAAQGEMLYLATRIEQENV-INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
N LS +AAQG+ L + Q + I+ + TPL AA G V + LL GA
Sbjct: 337 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 396
Query: 208 PQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKML 267
P + L +AC K + ++++LL G ++ +G TPL A H+ VK L
Sbjct: 397 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 456
Query: 268 LESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE 313
L+ GA P + + +A G+ V + + + K+ K+
Sbjct: 457 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD 502
Score = 63.9 bits (154), Expect = 2e-10
Identities = 43/149 (28%), Positives = 69/149 (46%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A +G +A + ++ N ++ G TPL A G + V + L+++G
Sbjct: 672 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT 731
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+ + L +A G +VK LL DVN G +PL A H V +LL++GA
Sbjct: 732 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 791
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVIE 301
P + G + +A LGY SV V++
Sbjct: 792 SPNEVSSDGTTPLAIAKRLGYISVTDVLK 820
Score = 63.5 bits (153), Expect = 2e-10
Identities = 42/144 (29%), Positives = 66/144 (45%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A Q ++ + ++ N +G TPL AA G +V LL A+ L
Sbjct: 639 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN 698
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
K + L L +G+ + +L+ GV V+ G TPL A H ++K VK LL+ A
Sbjct: 699 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 758
Query: 273 DPTIETDSGYNSMDLAVALGYRSV 296
D +T GY+ + A G+ +
Sbjct: 759 DVNAKTKLGYSPLHQAAQQGHTDI 782
Score = 61.6 bits (148), Expect = 9e-10
Identities = 53/190 (27%), Positives = 79/190 (41%), Gaps = 12/190 (6%)
Query: 111 VRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTP-LLANSLSVHQLAAQGEM-LYLATR 168
V+++ + + S +K T L R LL N V+ A + L+ A R
Sbjct: 453 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 512
Query: 169 IEQENVI----------NHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESA 218
I N++ N G TPL AA G + V LL+ A + K +
Sbjct: 513 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 572
Query: 219 LSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIET 278
L +A G + ++LL+ N NG TPL AVH N++ VK+LL G P
Sbjct: 573 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 632
Query: 279 DSGYNSMDLA 288
+GY + +A
Sbjct: 633 WNGYTPLHIA 642
Score = 60.8 bits (146), Expect = 1e-09
Identities = 42/148 (28%), Positives = 69/148 (46%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H + G + + +++ N ++ + TPL AA G V ++LLQN A
Sbjct: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
K ++ L A G+T++VK+LL+ + N G TPL A HV+ V LLE A
Sbjct: 501 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 560
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVI 300
T G+ + +A G V +++
Sbjct: 561 SQACMTKKGFTPLHVAAKYGKVRVAELL 588
Score = 54.7 bits (130), Expect = 1e-07
Identities = 36/137 (26%), Positives = 65/137 (47%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
++H A + A ++ + + + GFTPL AA + + V + LL GA
Sbjct: 209 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 268
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESG 271
+ + L +A +G +V++LLD G + + TPL A HV+ ++LL+ G
Sbjct: 269 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 328
Query: 272 ADPTIETDSGYNSMDLA 288
A +T +G + + +A
Sbjct: 329 APIQAKTKNGLSPIHMA 345
Score = 52.8 bits (125), Expect = 4e-07
Identities = 38/137 (27%), Positives = 64/137 (46%), Gaps = 1/137 (0%)
Query: 136 HRGNEVSTTPLLANSLS-VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQ 194
H N V N L+ +H + +G + + + +E ++ T ++G T L AA GQ
Sbjct: 64 HLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQ 123
Query: 195 IAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLY 254
VV L+ GA+ + + L +A + + ++VK LL+ G + N +G TPL
Sbjct: 124 DEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAV 183
Query: 255 AVHGNHVKCVKMLLESG 271
A+ H V L+ G
Sbjct: 184 ALQQGHENVVAHLINYG 200
Score = 51.6 bits (122), Expect = 9e-07
Identities = 44/186 (23%), Positives = 79/186 (42%), Gaps = 30/186 (16%)
Query: 136 HRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQI 195
H+ + TT N+ ++H A G+ + + +N ++GFTPL AA +
Sbjct: 99 HKEIILETTTKKGNT-ALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 157
Query: 196 AVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVD--------------- 240
VV+FLL+NGA+ + + + L++A +G+ ++V L++ G
Sbjct: 158 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 217
Query: 241 -------VNEYDWN-------GGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMD 286
+ + D N G TPL A H ++ ++LL GA +G +
Sbjct: 218 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 277
Query: 287 LAVALG 292
+A G
Sbjct: 278 IASRRG 283
Score = 49.3 bits (116), Expect = 4e-06
Identities = 34/122 (27%), Positives = 53/122 (43%)
Query: 182 GFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDV 241
G+TPL AA Q+ V LLQ G + L LA +G+ ++V +LL +
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 694
Query: 242 NEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIE 301
N + +G TPL HV +L++ G T GY + +A G + + +
Sbjct: 695 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 754
Query: 302 SH 303
H
Sbjct: 755 QH 756
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 76.6 bits (187), Expect = 3e-14
Identities = 55/218 (25%), Positives = 103/218 (47%), Gaps = 12/218 (5%)
Query: 85 NSDLEVASVLFKAECNIHTSPSPGIQVRHVYTP-STTKHFSPIKQSTTLTNKHRGNEVST 143
N D A+VL + P+P + + +TP H+ + + L N RG V+
Sbjct: 183 NDDTRTAAVL------LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN--RGASVNF 234
Query: 144 TPLLANSLS-VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLL 202
TP N ++ +H + +G ++ + +++ I ++ TPL AA +G + + E LL
Sbjct: 235 TP--QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 203 QNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVK 262
+GA Q K S + +A + D V++LL ++++ + TPL A H H +
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 263 CVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
K+LL+ GA P +G+ + +A + V +++
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Score = 76.3 bits (186), Expect = 3e-14
Identities = 49/155 (31%), Positives = 74/155 (47%)
Query: 148 ANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
A +H A +G + + +E+E ++GFTPL AA +G++ V E LL+ A
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 208 PQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKML 267
P GK + L +A DIVK+LL G + WNG TPL A N V+ + L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 268 LESGADPTIETDSGYNSMDLAVALGYRSVQQVIES 302
L+ G E+ G + LA G+ + ++ S
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Score = 71.6 bits (174), Expect = 8e-13
Identities = 41/119 (34%), Positives = 62/119 (52%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
I+ E G TPL A+ G + +V+ LLQ GA P + E+ L +A G+T++ K L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGY 293
L VN + TPL A H VK+LLE+ A+P + T +G+ + +A G+
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Score = 68.2 bits (165), Expect = 9e-12
Identities = 38/122 (31%), Positives = 64/122 (52%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
IN ++ G L A+ G + +V LL + K +AL +A G ++V+ L
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYR 294
++ G +VN G TPL A NH++ VK LLE+GA+ + T+ G+ + +A+ G+
Sbjct: 98 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 157
Query: 295 SV 296
+V
Sbjct: 158 NV 159
Score = 65.1 bits (157), Expect = 8e-11
Identities = 47/166 (28%), Positives = 75/166 (45%), Gaps = 1/166 (0%)
Query: 149 NSLSVHQLAAQGEMLYLATRIEQENV-INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
N LS +AAQG+ L + Q + I+ + TPL AA G V + LL GA
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 208 PQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKML 267
P + L +AC K + ++++LL G ++ +G TPL A H+ VK L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 268 LESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE 313
L+ GA P + + +A G+ V + + + K+ K+
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD 469
Score = 63.9 bits (154), Expect = 2e-10
Identities = 43/149 (28%), Positives = 69/149 (46%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A +G +A + ++ N ++ G TPL A G + V + L+++G
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT 698
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+ + L +A G +VK LL DVN G +PL A H V +LL++GA
Sbjct: 699 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 758
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVIE 301
P + G + +A LGY SV V++
Sbjct: 759 SPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 63.5 bits (153), Expect = 2e-10
Identities = 42/144 (29%), Positives = 66/144 (45%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A Q ++ + ++ N +G TPL AA G +V LL A+ L
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN 665
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
K + L L +G+ + +L+ GV V+ G TPL A H ++K VK LL+ A
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Query: 273 DPTIETDSGYNSMDLAVALGYRSV 296
D +T GY+ + A G+ +
Sbjct: 726 DVNAKTKLGYSPLHQAAQQGHTDI 749
Score = 61.6 bits (148), Expect = 9e-10
Identities = 53/190 (27%), Positives = 79/190 (41%), Gaps = 12/190 (6%)
Query: 111 VRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTP-LLANSLSVHQLAAQGEM-LYLATR 168
V+++ + + S +K T L R LL N V+ A + L+ A R
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 169 IEQENVI----------NHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESA 218
I N++ N G TPL AA G + V LL+ A + K +
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Query: 219 LSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIET 278
L +A G + ++LL+ N NG TPL AVH N++ VK+LL G P
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 279 DSGYNSMDLA 288
+GY + +A
Sbjct: 600 WNGYTPLHIA 609
Score = 60.8 bits (146), Expect = 1e-09
Identities = 42/148 (28%), Positives = 69/148 (46%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H + G + + +++ N ++ + TPL AA G V ++LLQN A
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
K ++ L A G+T++VK+LL+ + N G TPL A HV+ V LLE A
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVI 300
T G+ + +A G V +++
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 54.7 bits (130), Expect = 1e-07
Identities = 36/137 (26%), Positives = 65/137 (47%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
++H A + A ++ + + + GFTPL AA + + V + LL GA
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESG 271
+ + L +A +G +V++LLD G + + TPL A HV+ ++LL+ G
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 272 ADPTIETDSGYNSMDLA 288
A +T +G + + +A
Sbjct: 296 APIQAKTKNGLSPIHMA 312
Score = 52.8 bits (125), Expect = 4e-07
Identities = 38/137 (27%), Positives = 64/137 (46%), Gaps = 1/137 (0%)
Query: 136 HRGNEVSTTPLLANSLS-VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQ 194
H N V N L+ +H + +G + + + +E ++ T ++G T L AA GQ
Sbjct: 31 HLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQ 90
Query: 195 IAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLY 254
VV L+ GA+ + + L +A + + ++VK LL+ G + N +G TPL
Sbjct: 91 DEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAV 150
Query: 255 AVHGNHVKCVKMLLESG 271
A+ H V L+ G
Sbjct: 151 ALQQGHENVVAHLINYG 167
Score = 51.6 bits (122), Expect = 9e-07
Identities = 44/186 (23%), Positives = 79/186 (42%), Gaps = 30/186 (16%)
Query: 136 HRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQI 195
H+ + TT N+ ++H A G+ + + +N ++GFTPL AA +
Sbjct: 66 HKEIILETTTKKGNT-ALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 196 AVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVD--------------- 240
VV+FLL+NGA+ + + + L++A +G+ ++V L++ G
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 184
Query: 241 -------VNEYDWN-------GGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMD 286
+ + D N G TPL A H ++ ++LL GA +G +
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 287 LAVALG 292
+A G
Sbjct: 245 IASRRG 250
Score = 49.3 bits (116), Expect = 4e-06
Identities = 34/122 (27%), Positives = 53/122 (43%)
Query: 182 GFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDV 241
G+TPL AA Q+ V LLQ G + L LA +G+ ++V +LL +
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 242 NEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIE 301
N + +G TPL HV +L++ G T GY + +A G + + +
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
Query: 302 SH 303
H
Sbjct: 722 QH 723
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 76.6 bits (187), Expect = 3e-14
Identities = 55/218 (25%), Positives = 103/218 (47%), Gaps = 12/218 (5%)
Query: 85 NSDLEVASVLFKAECNIHTSPSPGIQVRHVYTP-STTKHFSPIKQSTTLTNKHRGNEVST 143
N D A+VL + P+P + + +TP H+ + + L N RG V+
Sbjct: 183 NDDTRTAAVL------LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN--RGASVNF 234
Query: 144 TPLLANSLS-VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLL 202
TP N ++ +H + +G ++ + +++ I ++ TPL AA +G + + E LL
Sbjct: 235 TP--QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 203 QNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVK 262
+GA Q K S + +A + D V++LL ++++ + TPL A H H +
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 263 CVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
K+LL+ GA P +G+ + +A + V +++
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Score = 76.3 bits (186), Expect = 3e-14
Identities = 49/155 (31%), Positives = 74/155 (47%)
Query: 148 ANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
A +H A +G + + +E+E ++GFTPL AA +G++ V E LL+ A
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 208 PQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKML 267
P GK + L +A DIVK+LL G + WNG TPL A N V+ + L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 268 LESGADPTIETDSGYNSMDLAVALGYRSVQQVIES 302
L+ G E+ G + LA G+ + ++ S
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Score = 71.6 bits (174), Expect = 8e-13
Identities = 41/119 (34%), Positives = 62/119 (52%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
I+ E G TPL A+ G + +V+ LLQ GA P + E+ L +A G+T++ K L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGY 293
L VN + TPL A H VK+LLE+ A+P + T +G+ + +A G+
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Score = 68.2 bits (165), Expect = 9e-12
Identities = 38/122 (31%), Positives = 64/122 (52%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
IN ++ G L A+ G + +V LL + K +AL +A G ++V+ L
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYR 294
++ G +VN G TPL A NH++ VK LLE+GA+ + T+ G+ + +A+ G+
Sbjct: 98 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 157
Query: 295 SV 296
+V
Sbjct: 158 NV 159
Score = 65.1 bits (157), Expect = 8e-11
Identities = 47/166 (28%), Positives = 75/166 (45%), Gaps = 1/166 (0%)
Query: 149 NSLSVHQLAAQGEMLYLATRIEQENV-INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
N LS +AAQG+ L + Q + I+ + TPL AA G V + LL GA
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 208 PQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKML 267
P + L +AC K + ++++LL G ++ +G TPL A H+ VK L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 268 LESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE 313
L+ GA P + + +A G+ V + + + K+ K+
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD 469
Score = 63.9 bits (154), Expect = 2e-10
Identities = 43/149 (28%), Positives = 69/149 (46%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A +G +A + ++ N ++ G TPL A G + V + L+++G
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT 698
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+ + L +A G +VK LL DVN G +PL A H V +LL++GA
Sbjct: 699 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 758
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVIE 301
P + G + +A LGY SV V++
Sbjct: 759 SPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 63.5 bits (153), Expect = 2e-10
Identities = 42/144 (29%), Positives = 66/144 (45%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A Q ++ + ++ N +G TPL AA G +V LL A+ L
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN 665
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
K + L L +G+ + +L+ GV V+ G TPL A H ++K VK LL+ A
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Query: 273 DPTIETDSGYNSMDLAVALGYRSV 296
D +T GY+ + A G+ +
Sbjct: 726 DVNAKTKLGYSPLHQAAQQGHTDI 749
Score = 61.6 bits (148), Expect = 9e-10
Identities = 53/190 (27%), Positives = 79/190 (41%), Gaps = 12/190 (6%)
Query: 111 VRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTP-LLANSLSVHQLAAQGEM-LYLATR 168
V+++ + + S +K T L R LL N V+ A + L+ A R
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 169 IEQENVI----------NHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESA 218
I N++ N G TPL AA G + V LL+ A + K +
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Query: 219 LSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIET 278
L +A G + ++LL+ N NG TPL AVH N++ VK+LL G P
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 279 DSGYNSMDLA 288
+GY + +A
Sbjct: 600 WNGYTPLHIA 609
Score = 60.8 bits (146), Expect = 1e-09
Identities = 42/148 (28%), Positives = 69/148 (46%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H + G + + +++ N ++ + TPL AA G V ++LLQN A
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
K ++ L A G+T++VK+LL+ + N G TPL A HV+ V LLE A
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVI 300
T G+ + +A G V +++
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 54.7 bits (130), Expect = 1e-07
Identities = 36/137 (26%), Positives = 65/137 (47%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
++H A + A ++ + + + GFTPL AA + + V + LL GA
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESG 271
+ + L +A +G +V++LLD G + + TPL A HV+ ++LL+ G
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 272 ADPTIETDSGYNSMDLA 288
A +T +G + + +A
Sbjct: 296 APIQAKTKNGLSPIHMA 312
Score = 52.8 bits (125), Expect = 4e-07
Identities = 38/137 (27%), Positives = 64/137 (46%), Gaps = 1/137 (0%)
Query: 136 HRGNEVSTTPLLANSLS-VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQ 194
H N V N L+ +H + +G + + + +E ++ T ++G T L AA GQ
Sbjct: 31 HLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQ 90
Query: 195 IAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLY 254
VV L+ GA+ + + L +A + + ++VK LL+ G + N +G TPL
Sbjct: 91 DEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAV 150
Query: 255 AVHGNHVKCVKMLLESG 271
A+ H V L+ G
Sbjct: 151 ALQQGHENVVAHLINYG 167
Score = 51.6 bits (122), Expect = 9e-07
Identities = 44/186 (23%), Positives = 79/186 (42%), Gaps = 30/186 (16%)
Query: 136 HRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQI 195
H+ + TT N+ ++H A G+ + + +N ++GFTPL AA +
Sbjct: 66 HKEIILETTTKKGNT-ALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 196 AVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVD--------------- 240
VV+FLL+NGA+ + + + L++A +G+ ++V L++ G
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 184
Query: 241 -------VNEYDWN-------GGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMD 286
+ + D N G TPL A H ++ ++LL GA +G +
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 287 LAVALG 292
+A G
Sbjct: 245 IASRRG 250
Score = 49.3 bits (116), Expect = 4e-06
Identities = 34/122 (27%), Positives = 53/122 (43%)
Query: 182 GFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDV 241
G+TPL AA Q+ V LLQ G + L LA +G+ ++V +LL +
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 242 NEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIE 301
N + +G TPL HV +L++ G T GY + +A G + + +
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
Query: 302 SH 303
H
Sbjct: 722 QH 723
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 76.6 bits (187), Expect = 3e-14
Identities = 55/218 (25%), Positives = 103/218 (47%), Gaps = 12/218 (5%)
Query: 85 NSDLEVASVLFKAECNIHTSPSPGIQVRHVYTP-STTKHFSPIKQSTTLTNKHRGNEVST 143
N D A+VL + P+P + + +TP H+ + + L N RG V+
Sbjct: 183 NDDTRTAAVL------LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN--RGASVNF 234
Query: 144 TPLLANSLS-VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLL 202
TP N ++ +H + +G ++ + +++ I ++ TPL AA +G + + E LL
Sbjct: 235 TP--QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 203 QNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVK 262
+GA Q K S + +A + D V++LL ++++ + TPL A H H +
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 263 CVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
K+LL+ GA P +G+ + +A + V +++
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Score = 76.3 bits (186), Expect = 3e-14
Identities = 49/155 (31%), Positives = 74/155 (47%)
Query: 148 ANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
A +H A +G + + +E+E ++GFTPL AA +G++ V E LL+ A
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 208 PQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKML 267
P GK + L +A DIVK+LL G + WNG TPL A N V+ + L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 268 LESGADPTIETDSGYNSMDLAVALGYRSVQQVIES 302
L+ G E+ G + LA G+ + ++ S
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Score = 71.6 bits (174), Expect = 8e-13
Identities = 41/119 (34%), Positives = 62/119 (52%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
I+ E G TPL A+ G + +V+ LLQ GA P + E+ L +A G+T++ K L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGY 293
L VN + TPL A H VK+LLE+ A+P + T +G+ + +A G+
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Score = 68.2 bits (165), Expect = 9e-12
Identities = 38/122 (31%), Positives = 64/122 (52%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
IN ++ G L A+ G + +V LL + K +AL +A G ++V+ L
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYR 294
++ G +VN G TPL A NH++ VK LLE+GA+ + T+ G+ + +A+ G+
Sbjct: 98 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 157
Query: 295 SV 296
+V
Sbjct: 158 NV 159
Score = 65.1 bits (157), Expect = 8e-11
Identities = 47/166 (28%), Positives = 75/166 (45%), Gaps = 1/166 (0%)
Query: 149 NSLSVHQLAAQGEMLYLATRIEQENV-INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
N LS +AAQG+ L + Q + I+ + TPL AA G V + LL GA
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 208 PQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKML 267
P + L +AC K + ++++LL G ++ +G TPL A H+ VK L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 268 LESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE 313
L+ GA P + + +A G+ V + + + K+ K+
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD 469
Score = 63.9 bits (154), Expect = 2e-10
Identities = 43/149 (28%), Positives = 69/149 (46%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A +G +A + ++ N ++ G TPL A G + V + L+++G
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT 698
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+ + L +A G +VK LL DVN G +PL A H V +LL++GA
Sbjct: 699 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 758
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVIE 301
P + G + +A LGY SV V++
Sbjct: 759 SPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 63.5 bits (153), Expect = 2e-10
Identities = 42/144 (29%), Positives = 66/144 (45%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A Q ++ + ++ N +G TPL AA G +V LL A+ L
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN 665
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
K + L L +G+ + +L+ GV V+ G TPL A H ++K VK LL+ A
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Query: 273 DPTIETDSGYNSMDLAVALGYRSV 296
D +T GY+ + A G+ +
Sbjct: 726 DVNAKTKLGYSPLHQAAQQGHTDI 749
Score = 61.6 bits (148), Expect = 9e-10
Identities = 53/190 (27%), Positives = 79/190 (41%), Gaps = 12/190 (6%)
Query: 111 VRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTP-LLANSLSVHQLAAQGEM-LYLATR 168
V+++ + + S +K T L R LL N V+ A + L+ A R
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 169 IEQENVI----------NHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESA 218
I N++ N G TPL AA G + V LL+ A + K +
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Query: 219 LSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIET 278
L +A G + ++LL+ N NG TPL AVH N++ VK+LL G P
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 279 DSGYNSMDLA 288
+GY + +A
Sbjct: 600 WNGYTPLHIA 609
Score = 60.8 bits (146), Expect = 1e-09
Identities = 42/148 (28%), Positives = 69/148 (46%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H + G + + +++ N ++ + TPL AA G V ++LLQN A
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
K ++ L A G+T++VK+LL+ + N G TPL A HV+ V LLE A
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVI 300
T G+ + +A G V +++
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 54.7 bits (130), Expect = 1e-07
Identities = 36/137 (26%), Positives = 65/137 (47%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
++H A + A ++ + + + GFTPL AA + + V + LL GA
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESG 271
+ + L +A +G +V++LLD G + + TPL A HV+ ++LL+ G
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 272 ADPTIETDSGYNSMDLA 288
A +T +G + + +A
Sbjct: 296 APIQAKTKNGLSPIHMA 312
Score = 52.8 bits (125), Expect = 4e-07
Identities = 38/137 (27%), Positives = 64/137 (46%), Gaps = 1/137 (0%)
Query: 136 HRGNEVSTTPLLANSLS-VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQ 194
H N V N L+ +H + +G + + + +E ++ T ++G T L AA GQ
Sbjct: 31 HLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQ 90
Query: 195 IAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLY 254
VV L+ GA+ + + L +A + + ++VK LL+ G + N +G TPL
Sbjct: 91 DEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAV 150
Query: 255 AVHGNHVKCVKMLLESG 271
A+ H V L+ G
Sbjct: 151 ALQQGHENVVAHLINYG 167
Score = 51.6 bits (122), Expect = 9e-07
Identities = 44/186 (23%), Positives = 79/186 (42%), Gaps = 30/186 (16%)
Query: 136 HRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQI 195
H+ + TT N+ ++H A G+ + + +N ++GFTPL AA +
Sbjct: 66 HKEIILETTTKKGNT-ALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 196 AVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVD--------------- 240
VV+FLL+NGA+ + + + L++A +G+ ++V L++ G
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 184
Query: 241 -------VNEYDWN-------GGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMD 286
+ + D N G TPL A H ++ ++LL GA +G +
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 287 LAVALG 292
+A G
Sbjct: 245 IASRRG 250
Score = 49.3 bits (116), Expect = 4e-06
Identities = 34/122 (27%), Positives = 53/122 (43%)
Query: 182 GFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDV 241
G+TPL AA Q+ V LLQ G + L LA +G+ ++V +LL +
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 242 NEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIE 301
N + +G TPL HV +L++ G T GY + +A G + + +
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
Query: 302 SH 303
H
Sbjct: 722 QH 723
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 76.6 bits (187), Expect = 3e-14
Identities = 55/218 (25%), Positives = 103/218 (47%), Gaps = 12/218 (5%)
Query: 85 NSDLEVASVLFKAECNIHTSPSPGIQVRHVYTP-STTKHFSPIKQSTTLTNKHRGNEVST 143
N D A+VL + P+P + + +TP H+ + + L N RG V+
Sbjct: 183 NDDTRTAAVL------LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN--RGASVNF 234
Query: 144 TPLLANSLS-VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLL 202
TP N ++ +H + +G ++ + +++ I ++ TPL AA +G + + E LL
Sbjct: 235 TP--QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 203 QNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVK 262
+GA Q K S + +A + D V++LL ++++ + TPL A H H +
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 263 CVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
K+LL+ GA P +G+ + +A + V +++
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Score = 76.3 bits (186), Expect = 3e-14
Identities = 49/155 (31%), Positives = 74/155 (47%)
Query: 148 ANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
A +H A +G + + +E+E ++GFTPL AA +G++ V E LL+ A
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 208 PQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKML 267
P GK + L +A DIVK+LL G + WNG TPL A N V+ + L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 268 LESGADPTIETDSGYNSMDLAVALGYRSVQQVIES 302
L+ G E+ G + LA G+ + ++ S
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Score = 71.6 bits (174), Expect = 8e-13
Identities = 41/119 (34%), Positives = 62/119 (52%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
I+ E G TPL A+ G + +V+ LLQ GA P + E+ L +A G+T++ K L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGY 293
L VN + TPL A H VK+LLE+ A+P + T +G+ + +A G+
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Score = 68.2 bits (165), Expect = 9e-12
Identities = 38/122 (31%), Positives = 64/122 (52%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
IN ++ G L A+ G + +V LL + K +AL +A G ++V+ L
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYR 294
++ G +VN G TPL A NH++ VK LLE+GA+ + T+ G+ + +A+ G+
Sbjct: 98 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 157
Query: 295 SV 296
+V
Sbjct: 158 NV 159
Score = 65.1 bits (157), Expect = 8e-11
Identities = 47/166 (28%), Positives = 75/166 (45%), Gaps = 1/166 (0%)
Query: 149 NSLSVHQLAAQGEMLYLATRIEQENV-INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
N LS +AAQG+ L + Q + I+ + TPL AA G V + LL GA
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 208 PQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKML 267
P + L +AC K + ++++LL G ++ +G TPL A H+ VK L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 268 LESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE 313
L+ GA P + + +A G+ V + + + K+ K+
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD 469
Score = 63.9 bits (154), Expect = 2e-10
Identities = 43/149 (28%), Positives = 69/149 (46%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A +G +A + ++ N ++ G TPL A G + V + L+++G
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATT 698
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+ + L +A G +VK LL DVN G +PL A H V +LL++GA
Sbjct: 699 RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGA 758
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVIE 301
P + G + +A LGY SV V++
Sbjct: 759 SPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 63.5 bits (153), Expect = 2e-10
Identities = 42/144 (29%), Positives = 66/144 (45%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A Q ++ + ++ N +G TPL AA G +V LL A+ L
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN 665
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
K + L L +G+ + +L+ GV V+ G TPL A H ++K VK LL+ A
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Query: 273 DPTIETDSGYNSMDLAVALGYRSV 296
D +T GY+ + A G+ +
Sbjct: 726 DVNAKTKLGYSPLHQAAQQGHTDI 749
Score = 61.6 bits (148), Expect = 9e-10
Identities = 53/190 (27%), Positives = 79/190 (41%), Gaps = 12/190 (6%)
Query: 111 VRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTP-LLANSLSVHQLAAQGEM-LYLATR 168
V+++ + + S +K T L R LL N V+ A + L+ A R
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 169 IEQENVI----------NHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESA 218
I N++ N G TPL AA G + V LL+ A + K +
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Query: 219 LSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIET 278
L +A G + ++LL+ N NG TPL AVH N++ VK+LL G P
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 279 DSGYNSMDLA 288
+GY + +A
Sbjct: 600 WNGYTPLHIA 609
Score = 60.8 bits (146), Expect = 1e-09
Identities = 42/148 (28%), Positives = 69/148 (46%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H + G + + +++ N ++ + TPL AA G V ++LLQN A
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
K ++ L A G+T++VK+LL+ + N G TPL A HV+ V LLE A
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVI 300
T G+ + +A G V +++
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 54.7 bits (130), Expect = 1e-07
Identities = 36/137 (26%), Positives = 65/137 (47%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
++H A + A ++ + + + GFTPL AA + + V + LL GA
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESG 271
+ + L +A +G +V++LLD G + + TPL A HV+ ++LL+ G
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 272 ADPTIETDSGYNSMDLA 288
A +T +G + + +A
Sbjct: 296 APIQAKTKNGLSPIHMA 312
Score = 52.8 bits (125), Expect = 4e-07
Identities = 38/137 (27%), Positives = 64/137 (46%), Gaps = 1/137 (0%)
Query: 136 HRGNEVSTTPLLANSLS-VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQ 194
H N V N L+ +H + +G + + + +E ++ T ++G T L AA GQ
Sbjct: 31 HLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQ 90
Query: 195 IAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLY 254
VV L+ GA+ + + L +A + + ++VK LL+ G + N +G TPL
Sbjct: 91 DEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAV 150
Query: 255 AVHGNHVKCVKMLLESG 271
A+ H V L+ G
Sbjct: 151 ALQQGHENVVAHLINYG 167
Score = 51.6 bits (122), Expect = 9e-07
Identities = 44/186 (23%), Positives = 79/186 (42%), Gaps = 30/186 (16%)
Query: 136 HRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQI 195
H+ + TT N+ ++H A G+ + + +N ++GFTPL AA +
Sbjct: 66 HKEIILETTTKKGNT-ALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 196 AVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVD--------------- 240
VV+FLL+NGA+ + + + L++A +G+ ++V L++ G
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 184
Query: 241 -------VNEYDWN-------GGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMD 286
+ + D N G TPL A H ++ ++LL GA +G +
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 287 LAVALG 292
+A G
Sbjct: 245 IASRRG 250
Score = 49.3 bits (116), Expect = 4e-06
Identities = 34/122 (27%), Positives = 53/122 (43%)
Query: 182 GFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDV 241
G+TPL AA Q+ V LLQ G + L LA +G+ ++V +LL +
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 242 NEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIE 301
N + +G TPL HV +L++ G T GY + +A G + + +
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL 721
Query: 302 SH 303
H
Sbjct: 722 QH 723
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 76.3 bits (186), Expect = 3e-14
Identities = 53/145 (36%), Positives = 71/145 (48%), Gaps = 1/145 (0%)
Query: 149 NSLSVHQLAAQGEMLYLATRI-EQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
++L V LA G++ L I +++ TD++ T L WA + G +VEFLLQ G
Sbjct: 6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP 65
Query: 208 PQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKML 267
S L +A S G +IVK LL G VN + NG TPL YA N + ML
Sbjct: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
Query: 268 LESGADPTIETDSGYNSMDLAVALG 292
LE GA+P + +M A A G
Sbjct: 126 LEGGANPDAKDHYEATAMHRAAAKG 150
Score = 54.3 bits (129), Expect = 1e-07
Identities = 36/136 (26%), Positives = 61/136 (44%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A+ G + + + +N ++ G TPL +AA+ + + LL+ GA+P
Sbjct: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+A+ A +KG ++ +LL N D G TPL A V+ K+L+ GA
Sbjct: 137 HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA 196
Query: 273 DPTIETDSGYNSMDLA 288
IE + +A
Sbjct: 197 SIYIENKEEKTPLQVA 212
Score = 30.8 bits (68), Expect = 1.6
Identities = 18/71 (25%), Positives = 34/71 (47%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
++H+ AA+G + + + + N D EG TPL A ++ + L+ GA +
Sbjct: 142 AMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIE 201
Query: 212 GKGRESALSLA 222
K ++ L +A
Sbjct: 202 NKEEKTPLQVA 212
Score = 28.9 bits (63), Expect = 6.2
Identities = 20/75 (26%), Positives = 32/75 (42%)
Query: 184 TPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNE 243
T + AAA G + ++ LL A + + L LAC + + K+L+ G +
Sbjct: 141 TAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYI 200
Query: 244 YDWNGGTPLLYAVHG 258
+ TPL A G
Sbjct: 201 ENKEEKTPLQVAKGG 215
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 76.3 bits (186), Expect = 3e-14
Identities = 42/126 (33%), Positives = 68/126 (53%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
IN ++ G L A+ G + VV LLQ A+ K +AL +A G ++VK+L
Sbjct: 67 INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYR 294
+ G +VN NG TPL A NH++ VK LL++GA ++ T+ G+ + +A+ G+
Sbjct: 127 VTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHD 186
Query: 295 SVQQVI 300
V ++
Sbjct: 187 QVVSLL 192
Score = 71.2 bits (173), Expect = 1e-12
Identities = 46/150 (30%), Positives = 71/150 (47%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
SVH A +G + ++ + + +N +++ G TPL AA ++ V E L+ GA
Sbjct: 667 SVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQ 726
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESG 271
K + L + C G IV LL VN NG TPL A H + +LL++
Sbjct: 727 TKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNN 786
Query: 272 ADPTIETDSGYNSMDLAVALGYRSVQQVIE 301
A P T +G ++ +A LGY SV ++
Sbjct: 787 ASPNELTVNGNTALGIARRLGYISVVDTLK 816
Score = 68.2 bits (165), Expect = 9e-12
Identities = 46/141 (32%), Positives = 65/141 (46%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A +G A ++ ++ T ++GFTPL AA +G++ V LLQ A P G
Sbjct: 536 LHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAG 595
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
K + L +A + +LLD G + NG TPL A N + LLE GA
Sbjct: 596 KSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGA 655
Query: 273 DPTIETDSGYNSMDLAVALGY 293
D T G S+ LA G+
Sbjct: 656 DANAVTRQGIASVHLAAQEGH 676
Score = 66.6 bits (161), Expect = 3e-11
Identities = 39/129 (30%), Positives = 58/129 (44%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
I E G TP+ AA G + +V L+ +GA P E+AL +A G ++V+ L
Sbjct: 426 IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYR 294
+ G V + TPL + V+ LL+ GA P T SGY + L+ G+
Sbjct: 486 VQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHE 545
Query: 295 SVQQVIESH 303
V + H
Sbjct: 546 DVAAFLLDH 554
Score = 66.6 bits (161), Expect = 3e-11
Identities = 43/148 (29%), Positives = 67/148 (45%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A G + ++ + N T+ G T L AA GQ VV +L+Q+GA +
Sbjct: 437 IHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKA 496
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
K ++ L ++ G DIV+ LL G N +G TPL + H LL+ GA
Sbjct: 497 KDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGA 556
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVI 300
+I T G+ + +A G V ++
Sbjct: 557 SLSITTKKGFTPLHVAAKYGKLEVANLL 584
Score = 64.7 bits (156), Expect = 1e-10
Identities = 41/152 (26%), Positives = 73/152 (48%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
++H A + + A ++ +N + + GFTPL AA +G I V LL A
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESG 271
+ + L +A +G ++VK+LLD G ++ +G TPL H + V+MLL+
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324
Query: 272 ADPTIETDSGYNSMDLAVALGYRSVQQVIESH 303
A +T +G + + +A + + Q++ H
Sbjct: 325 APILSKTKNGLSPLHMATQGDHLNCVQLLLQH 356
Score = 62.4 bits (150), Expect = 5e-10
Identities = 53/217 (24%), Positives = 90/217 (41%), Gaps = 16/217 (7%)
Query: 88 LEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNK----HRGNEVST 143
LEVA++L + + + G+ HV H+ K + L ++ H +
Sbjct: 578 LEVANLLLQKSASPDAAGKSGLTPLHV-----AAHYDNQKVALLLLDQGASPHAAAKNGY 632
Query: 144 TPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQ 203
TPL H A + +M T +E N +G + AA G + +V LL
Sbjct: 633 TPL-------HIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLG 685
Query: 204 NGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKC 263
A+ L K + L LA + ++ ++L++ G V+ G TPL H ++K
Sbjct: 686 RNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKI 745
Query: 264 VKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVI 300
V LL+ A +T +GY + A G+ + V+
Sbjct: 746 VNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVL 782
Score = 60.8 bits (146), Expect = 1e-09
Identities = 36/128 (28%), Positives = 63/128 (49%)
Query: 180 EEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGV 239
+ G+TPL AA Q+ + LL+ GAD + + +++ LA +G+ D+V +LL
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA 688
Query: 240 DVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQV 299
+VN + +G TPL A + V ++L+ GA +T GY + + G +
Sbjct: 689 NVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNF 748
Query: 300 IESHLLKL 307
+ H K+
Sbjct: 749 LLQHSAKV 756
Score = 60.1 bits (144), Expect = 2e-09
Identities = 53/221 (23%), Positives = 91/221 (41%), Gaps = 16/221 (7%)
Query: 87 DLEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVST--- 143
D + A++L + + N G H+ H+ I +T L N+ + +
Sbjct: 214 DTKAAALLLQNDNNADVESKSGFTPLHI-----AAHYGNINVATLLLNRAAAVDFTARND 268
Query: 144 -TPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLL 202
TPL H + +G + +++ I+ +G TPL A G VVE LL
Sbjct: 269 ITPL-------HVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLL 321
Query: 203 QNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVK 262
A K S L +A + + V++LL V V++ + T L A H H K
Sbjct: 322 DRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYK 381
Query: 263 CVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESH 303
K+LL+ A+P + +G+ + +A V +++ H
Sbjct: 382 VAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKH 422
Score = 59.7 bits (143), Expect = 3e-09
Identities = 42/149 (28%), Positives = 63/149 (42%), Gaps = 1/149 (0%)
Query: 149 NSLSVHQLAAQGEMLYLATRIEQENV-INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGAD 207
N LS +A QG+ L + Q NV ++ + T L AA G V + LL A+
Sbjct: 333 NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
Query: 208 PQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKML 267
P + L +AC K ++++LL G + +G TP+ A HV V L
Sbjct: 393 PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQL 452
Query: 268 LESGADPTIETDSGYNSMDLAVALGYRSV 296
+ GA P G ++ +A G V
Sbjct: 453 MHHGASPNTTNVRGETALHMAARSGQAEV 481
Score = 58.5 bits (140), Expect = 7e-09
Identities = 49/202 (24%), Positives = 84/202 (41%), Gaps = 25/202 (12%)
Query: 111 VRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEM--LYLATR 168
+ H +P+TT ++ T L R + L + + A+ + L+++ R
Sbjct: 453 MHHGASPNTTN----VRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 508
Query: 169 IEQENVI----------NHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESA 218
+ + +++ N G+TPL +A G V FLL +GA + K +
Sbjct: 509 LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTP 568
Query: 219 LSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIET 278
L +A G ++ +LL + +G TPL A H ++ K +LL+ GA P
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628
Query: 279 DSGY---------NSMDLAVAL 291
+GY N MD+A L
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTL 650
Score = 57.0 bits (136), Expect = 2e-08
Identities = 44/160 (27%), Positives = 74/160 (46%), Gaps = 7/160 (4%)
Query: 144 TPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQ 203
TPL + S H+ EML +++ I + G +PL A + V+ LLQ
Sbjct: 303 TPLHCGARSGHEQVV--EML-----LDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ 355
Query: 204 NGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKC 263
+ + +AL +A G+ + K+LLD + N NG TPL A N +K
Sbjct: 356 HNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKV 415
Query: 264 VKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESH 303
+++LL+ GA T+SG + +A +G+ ++ + H
Sbjct: 416 MELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 455
Score = 55.8 bits (133), Expect = 5e-08
Identities = 33/119 (27%), Positives = 64/119 (53%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
++H + +G + ++ +++E ++ ++G T L A+ GQ VV+ L+ NGA+
Sbjct: 77 ALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ 136
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLES 270
+ + L +A + + ++VK LLD G + +G TPL A+ H + V +LLE+
Sbjct: 137 SQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN 195
Score = 55.8 bits (133), Expect = 5e-08
Identities = 40/148 (27%), Positives = 60/148 (40%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A G++ +++ + + G TPL AA + V LL GA P
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
K + L +A K DI LL+ G D N G + A HV V +LL A
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA 688
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVI 300
+ + SG + LA +V +V+
Sbjct: 689 NVNLSNKSGLTPLHLAAQEDRVNVAEVL 716
Score = 53.1 bits (126), Expect = 3e-07
Identities = 34/121 (28%), Positives = 58/121 (47%), Gaps = 1/121 (0%)
Query: 182 GFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDV 241
GFTPL A +I V+E LL++GA Q + + + + +A G+ +IV L+ G
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 459
Query: 242 NEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRS-VQQVI 300
N + G T L A + V+ L++ GA + + ++ LG VQQ++
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL 519
Query: 301 E 301
+
Sbjct: 520 Q 520
Score = 47.8 bits (112), Expect = 1e-05
Identities = 65/291 (22%), Positives = 101/291 (34%), Gaps = 53/291 (18%)
Query: 56 LPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHTSPSPGIQVRHVY 115
+ N D+N+C++ LN + + V EV S L + E N+ + G
Sbjct: 61 IKNGVDINICNQ--NGLNALHLASKEGHV----EVVSELLQREANVDAATKKG------- 107
Query: 116 TPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVI 175
+T H + + + N + N + +AAQ L + +
Sbjct: 108 --NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS 165
Query: 176 NH-TDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
E+GFTPL A G VV LL+N GK R AL +A K T +L
Sbjct: 166 QSLATEDGFTPLAVALQQGHDQVVSLLLENDTK----GKVRLPALHIAARKDDTKAAALL 221
Query: 235 LDCGVDVNEYDWNGGTPLLYAVH-GN--------------------------------HV 261
L + + +G TPL A H GN +
Sbjct: 222 LQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNA 281
Query: 262 KCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIK 312
VK+LL+ GA +T G + G+ V +++ +L K
Sbjct: 282 NMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTK 332
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 75.1 bits (183), Expect = 7e-14
Identities = 40/126 (31%), Positives = 66/126 (52%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
IN ++ G L AA G + +V+ LL G+ K +AL +A G ++VK+L
Sbjct: 36 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 95
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYR 294
+ G ++N NG TPL A NH+ VK LLE+GA+ + T+ G+ + +A+ G+
Sbjct: 96 VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 155
Query: 295 SVQQVI 300
++
Sbjct: 156 QAVAIL 161
Score = 73.6 bits (179), Expect = 2e-13
Identities = 41/120 (34%), Positives = 65/120 (54%)
Query: 169 IEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYT 228
++ + ++N T E GFTPL AA +G + V LL GA + + L +A +G T
Sbjct: 199 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNT 258
Query: 229 DIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLA 288
++VK+LLD G ++ +G TPL A H + V++LLE GA T +G + + +A
Sbjct: 259 NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 318
Score = 72.8 bits (177), Expect = 4e-13
Identities = 58/220 (26%), Positives = 95/220 (43%), Gaps = 16/220 (7%)
Query: 88 LEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNK----HRGNEVST 143
L+VA +L + ++ G+ HV H+ K + L K H +
Sbjct: 555 LDVAKLLLQRRAAADSAGKNGLTPLHV-----AAHYDNQKVALLLLEKGASPHATAKNGY 609
Query: 144 TPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQ 203
TPL H A + +M +T + N ++G TPL A+ G +V LL
Sbjct: 610 TPL-------HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 662
Query: 204 NGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKC 263
GA+ + K ++L LA + ++ +L G D + + G TPL+ A H +VK
Sbjct: 663 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 722
Query: 264 VKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESH 303
V LL+ GA+ +T +GY + A G+ + V+ H
Sbjct: 723 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 762
Score = 70.9 bits (172), Expect = 1e-12
Identities = 54/197 (27%), Positives = 88/197 (44%), Gaps = 4/197 (2%)
Query: 106 SPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQ-GEMLY 164
SP ++ YTP H + K + + T + ++ LA+Q G
Sbjct: 600 SPHATAKNGYTPL---HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 656
Query: 165 LATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACS 224
+ +++ I+ + + G T L AA ++ V + L ++GAD K + L +AC
Sbjct: 657 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACH 716
Query: 225 KGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNS 284
G +V LL G +VN NG TPL A H + +LL+ GA P T +G +
Sbjct: 717 YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 776
Query: 285 MDLAVALGYRSVQQVIE 301
+ +A LGY SV ++
Sbjct: 777 LAIAKRLGYISVVDTLK 793
Score = 66.2 bits (160), Expect = 3e-11
Identities = 54/207 (26%), Positives = 88/207 (42%), Gaps = 20/207 (9%)
Query: 111 VRHVYTP--STTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEM--LYLA 166
++H+ P +TT ++P+ S R +V +L + + H LA + L++A
Sbjct: 496 LQHMAHPDAATTNGYTPLHISA------REGQVDVASVLLEAGAAHSLATKKGFTPLHVA 549
Query: 167 TR----------IEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRE 216
+ +++ + + G TPL AA + V LL+ GA P K
Sbjct: 550 AKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY 609
Query: 217 SALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTI 276
+ L +A K I LL+ G + N G TPL A H V +LL+ GA+ +
Sbjct: 610 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 669
Query: 277 ETDSGYNSMDLAVALGYRSVQQVIESH 303
T SG S+ LA +V ++ H
Sbjct: 670 STKSGLTSLHLAAQEDKVNVADILTKH 696
Score = 62.4 bits (150), Expect = 5e-10
Identities = 40/121 (33%), Positives = 59/121 (48%)
Query: 180 EEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGV 239
E G TP+ AA G + +V LLQNGA P + E+AL +A G ++V+ LL G
Sbjct: 408 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 467
Query: 240 DVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQV 299
V+ TPL A + V++LL+ A P T +GY + ++ G V V
Sbjct: 468 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 527
Query: 300 I 300
+
Sbjct: 528 L 528
Score = 61.6 bits (148), Expect = 9e-10
Identities = 42/148 (28%), Positives = 70/148 (47%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A G + + ++ + T+ G T L AA GQ+ VV LL+NGA
Sbjct: 414 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 473
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+ ++ L +A G T+IV++LL + NG TPL + V +LLE+GA
Sbjct: 474 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 533
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVI 300
++ T G+ + +A G V +++
Sbjct: 534 AHSLATKKGFTPLHVAAKYGSLDVAKLL 561
Score = 59.3 bits (142), Expect = 4e-09
Identities = 47/168 (27%), Positives = 76/168 (45%), Gaps = 5/168 (2%)
Query: 122 HFSPIKQSTTLTNKHRGNEVSTTPLLANSLS-VHQLAAQGEMLYLATRIEQENVINHTDE 180
H+ + +T L N RG V T N ++ +H + +G + +++ I+
Sbjct: 221 HYGNVNVATLLLN--RGAAVDFTA--RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTR 276
Query: 181 EGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVD 240
+G TPL AA G VVE LL+ GA K S L +A + + VK LL
Sbjct: 277 DGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 336
Query: 241 VNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLA 288
V++ + T L A H H + K+LL+ A+P +G+ + +A
Sbjct: 337 VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 384
Score = 59.3 bits (142), Expect = 4e-09
Identities = 42/152 (27%), Positives = 69/152 (45%), Gaps = 4/152 (2%)
Query: 145 PLLA---NSLSVHQLAAQGEMLYLATRIEQENV-INHTDEEGFTPLMWAAAHGQIAVVEF 200
PLLA N LS +AAQG+ + + Q ++ + T L AA G V +
Sbjct: 303 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 362
Query: 201 LLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNH 260
LL A+P + L +AC K ++++L+ G + +G TP+ A H
Sbjct: 363 LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGH 422
Query: 261 VKCVKMLLESGADPTIETDSGYNSMDLAVALG 292
+ V +LL++GA P + G ++ +A G
Sbjct: 423 LNIVLLLLQNGASPDVTNIRGETALHMAARAG 454
Score = 56.6 bits (135), Expect = 3e-08
Identities = 44/158 (27%), Positives = 75/158 (47%), Gaps = 7/158 (4%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A G + +E+ + + G +PL AA + V+ LLQ+ A +
Sbjct: 282 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 341
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+AL +A G+ + K+LLD + N NG TPL A N +K +++L++ GA
Sbjct: 342 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 401
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQN 310
T+SG + +A +G+ ++ +L LLQN
Sbjct: 402 SIQAITESGLTPIHVAAFMGHLNI-------VLLLLQN 432
Score = 53.1 bits (126), Expect = 3e-07
Identities = 35/123 (28%), Positives = 58/123 (47%)
Query: 182 GFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDV 241
GFTPL A +I V+E L++ GA Q + + + + +A G+ +IV +LL G
Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436
Query: 242 NEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIE 301
+ + G T L A V+ V+ LL +GA + +A LG + Q++
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 496
Query: 302 SHL 304
H+
Sbjct: 497 QHM 499
Score = 52.0 bits (123), Expect = 7e-07
Identities = 32/119 (26%), Positives = 63/119 (52%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
++H A +G + + + + + ++ ++G T L A+ GQ VV+ L++ GA+
Sbjct: 46 ALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 105
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLES 270
+ + L +A + + D+VK LL+ G + + +G TPL A+ H + V +LLE+
Sbjct: 106 SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 164
Score = 51.2 bits (121), Expect = 1e-06
Identities = 46/172 (26%), Positives = 71/172 (41%), Gaps = 37/172 (21%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQ-- 209
++H A G++ + + +++ E TPL A+ G+ +V+ LLQ+ A P
Sbjct: 446 ALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAA 505
Query: 210 ----------------------LLGKGRESALSLACSKGYT-----------DIVKMLLD 236
LL G +A SLA KG+T D+ K+LL
Sbjct: 506 TTNGYTPLHISAREGQVDVASVLLEAG--AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 563
Query: 237 CGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLA 288
+ NG TPL A H ++ K +LLE GA P +GY + +A
Sbjct: 564 RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 615
Score = 42.7 bits (99), Expect = 4e-04
Identities = 28/100 (28%), Positives = 48/100 (48%)
Query: 189 AAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNG 248
AA G + V L+ G D + +AL LA +G+ +V+ LL G V+ G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 249 GTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLA 288
T L A + VK+L++ GA+ ++ +G+ + +A
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMA 116
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/234 (25%), Positives = 87/234 (37%), Gaps = 24/234 (10%)
Query: 89 EVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTL-TNKHRGNEVSTTPLL 147
EV VL K NI+ G +Y + H +K N+ E TPL
Sbjct: 90 EVVKVLVKEGANINAQSQNGFTP--LYMAAQENHIDVVKYLLENGANQSTATEDGFTPLA 147
Query: 148 ANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAH-GQIAVVEFLLQN-- 204
QG +A +E N T + P + AA LLQN
Sbjct: 148 V-------ALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALLLQNDH 195
Query: 205 GADPQ---LLGKGRESA---LSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHG 258
AD Q ++ + ES L +A G ++ +LL+ G V+ NG TPL A
Sbjct: 196 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 255
Query: 259 NHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIK 312
+ VK+LL+ G +T G + A G+ V +++ LL K
Sbjct: 256 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 309
Score = 34.7 bits (78), Expect = 0.11
Identities = 24/79 (30%), Positives = 34/79 (43%)
Query: 222 ACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSG 281
A G D V L G+D+N + NG L A HV V+ LL G+ T G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 282 YNSMDLAVALGYRSVQQVI 300
++ +A G V +V+
Sbjct: 77 NTALHIASLAGQAEVVKVL 95
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 75.1 bits (183), Expect = 7e-14
Identities = 40/126 (31%), Positives = 66/126 (52%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
IN ++ G L AA G + +V+ LL G+ K +AL +A G ++VK+L
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYR 294
+ G ++N NG TPL A NH+ VK LLE+GA+ + T+ G+ + +A+ G+
Sbjct: 117 VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176
Query: 295 SVQQVI 300
++
Sbjct: 177 QAVAIL 182
Score = 73.6 bits (179), Expect = 2e-13
Identities = 41/120 (34%), Positives = 65/120 (54%)
Query: 169 IEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYT 228
++ + ++N T E GFTPL AA +G + V LL GA + + L +A +G T
Sbjct: 220 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNT 279
Query: 229 DIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLA 288
++VK+LLD G ++ +G TPL A H + V++LLE GA T +G + + +A
Sbjct: 280 NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 339
Score = 72.8 bits (177), Expect = 4e-13
Identities = 58/220 (26%), Positives = 95/220 (43%), Gaps = 16/220 (7%)
Query: 88 LEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNK----HRGNEVST 143
L+VA +L + ++ G+ HV H+ K + L K H +
Sbjct: 576 LDVAKLLLQRRAAADSAGKNGLTPLHV-----AAHYDNQKVALLLLEKGASPHATAKNGY 630
Query: 144 TPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQ 203
TPL H A + +M +T + N ++G TPL A+ G +V LL
Sbjct: 631 TPL-------HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683
Query: 204 NGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKC 263
GA+ + K ++L LA + ++ +L G D + + G TPL+ A H +VK
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743
Query: 264 VKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESH 303
V LL+ GA+ +T +GY + A G+ + V+ H
Sbjct: 744 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Score = 70.9 bits (172), Expect = 1e-12
Identities = 54/197 (27%), Positives = 88/197 (44%), Gaps = 4/197 (2%)
Query: 106 SPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQ-GEMLY 164
SP ++ YTP H + K + + T + ++ LA+Q G
Sbjct: 621 SPHATAKNGYTPL---HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 677
Query: 165 LATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACS 224
+ +++ I+ + + G T L AA ++ V + L ++GAD K + L +AC
Sbjct: 678 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACH 737
Query: 225 KGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNS 284
G +V LL G +VN NG TPL A H + +LL+ GA P T +G +
Sbjct: 738 YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797
Query: 285 MDLAVALGYRSVQQVIE 301
+ +A LGY SV ++
Sbjct: 798 LAIAKRLGYISVVDTLK 814
Score = 66.2 bits (160), Expect = 3e-11
Identities = 54/207 (26%), Positives = 88/207 (42%), Gaps = 20/207 (9%)
Query: 111 VRHVYTP--STTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEM--LYLA 166
++H+ P +TT ++P+ S R +V +L + + H LA + L++A
Sbjct: 517 LQHMAHPDAATTNGYTPLHISA------REGQVDVASVLLEAGAAHSLATKKGFTPLHVA 570
Query: 167 TR----------IEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRE 216
+ +++ + + G TPL AA + V LL+ GA P K
Sbjct: 571 AKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY 630
Query: 217 SALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTI 276
+ L +A K I LL+ G + N G TPL A H V +LL+ GA+ +
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 690
Query: 277 ETDSGYNSMDLAVALGYRSVQQVIESH 303
T SG S+ LA +V ++ H
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKH 717
Score = 62.4 bits (150), Expect = 5e-10
Identities = 40/121 (33%), Positives = 59/121 (48%)
Query: 180 EEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGV 239
E G TP+ AA G + +V LLQNGA P + E+AL +A G ++V+ LL G
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488
Query: 240 DVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQV 299
V+ TPL A + V++LL+ A P T +GY + ++ G V V
Sbjct: 489 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 548
Query: 300 I 300
+
Sbjct: 549 L 549
Score = 61.6 bits (148), Expect = 9e-10
Identities = 42/148 (28%), Positives = 70/148 (47%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A G + + ++ + T+ G T L AA GQ+ VV LL+NGA
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+ ++ L +A G T+IV++LL + NG TPL + V +LLE+GA
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVI 300
++ T G+ + +A G V +++
Sbjct: 555 AHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Score = 59.3 bits (142), Expect = 4e-09
Identities = 47/168 (27%), Positives = 76/168 (45%), Gaps = 5/168 (2%)
Query: 122 HFSPIKQSTTLTNKHRGNEVSTTPLLANSLS-VHQLAAQGEMLYLATRIEQENVINHTDE 180
H+ + +T L N RG V T N ++ +H + +G + +++ I+
Sbjct: 242 HYGNVNVATLLLN--RGAAVDFTA--RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTR 297
Query: 181 EGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVD 240
+G TPL AA G VVE LL+ GA K S L +A + + VK LL
Sbjct: 298 DGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357
Query: 241 VNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLA 288
V++ + T L A H H + K+LL+ A+P +G+ + +A
Sbjct: 358 VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 405
Score = 59.3 bits (142), Expect = 4e-09
Identities = 42/152 (27%), Positives = 69/152 (45%), Gaps = 4/152 (2%)
Query: 145 PLLA---NSLSVHQLAAQGEMLYLATRIEQENV-INHTDEEGFTPLMWAAAHGQIAVVEF 200
PLLA N LS +AAQG+ + + Q ++ + T L AA G V +
Sbjct: 324 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383
Query: 201 LLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNH 260
LL A+P + L +AC K ++++L+ G + +G TP+ A H
Sbjct: 384 LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGH 443
Query: 261 VKCVKMLLESGADPTIETDSGYNSMDLAVALG 292
+ V +LL++GA P + G ++ +A G
Sbjct: 444 LNIVLLLLQNGASPDVTNIRGETALHMAARAG 475
Score = 56.6 bits (135), Expect = 3e-08
Identities = 44/158 (27%), Positives = 75/158 (47%), Gaps = 7/158 (4%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A G + +E+ + + G +PL AA + V+ LLQ+ A +
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 362
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+AL +A G+ + K+LLD + N NG TPL A N +K +++L++ GA
Sbjct: 363 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 422
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQN 310
T+SG + +A +G+ ++ +L LLQN
Sbjct: 423 SIQAITESGLTPIHVAAFMGHLNI-------VLLLLQN 453
Score = 53.1 bits (126), Expect = 3e-07
Identities = 35/123 (28%), Positives = 58/123 (47%)
Query: 182 GFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDV 241
GFTPL A +I V+E L++ GA Q + + + + +A G+ +IV +LL G
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 242 NEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIE 301
+ + G T L A V+ V+ LL +GA + +A LG + Q++
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517
Query: 302 SHL 304
H+
Sbjct: 518 QHM 520
Score = 52.0 bits (123), Expect = 7e-07
Identities = 32/119 (26%), Positives = 63/119 (52%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
++H A +G + + + + + ++ ++G T L A+ GQ VV+ L++ GA+
Sbjct: 67 ALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 126
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLES 270
+ + L +A + + D+VK LL+ G + + +G TPL A+ H + V +LLE+
Sbjct: 127 SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185
Score = 51.2 bits (121), Expect = 1e-06
Identities = 46/172 (26%), Positives = 71/172 (41%), Gaps = 37/172 (21%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQ-- 209
++H A G++ + + +++ E TPL A+ G+ +V+ LLQ+ A P
Sbjct: 467 ALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAA 526
Query: 210 ----------------------LLGKGRESALSLACSKGYT-----------DIVKMLLD 236
LL G +A SLA KG+T D+ K+LL
Sbjct: 527 TTNGYTPLHISAREGQVDVASVLLEAG--AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584
Query: 237 CGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLA 288
+ NG TPL A H ++ K +LLE GA P +GY + +A
Sbjct: 585 RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 636
Score = 42.7 bits (99), Expect = 4e-04
Identities = 28/100 (28%), Positives = 48/100 (48%)
Query: 189 AAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNG 248
AA G + V L+ G D + +AL LA +G+ +V+ LL G V+ G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 249 GTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLA 288
T L A + VK+L++ GA+ ++ +G+ + +A
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMA 137
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/234 (25%), Positives = 87/234 (37%), Gaps = 24/234 (10%)
Query: 89 EVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTL-TNKHRGNEVSTTPLL 147
EV VL K NI+ G +Y + H +K N+ E TPL
Sbjct: 111 EVVKVLVKEGANINAQSQNGFTP--LYMAAQENHIDVVKYLLENGANQSTATEDGFTPLA 168
Query: 148 ANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAH-GQIAVVEFLLQN-- 204
QG +A +E N T + P + AA LLQN
Sbjct: 169 V-------ALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALLLQNDH 216
Query: 205 GADPQ---LLGKGRESA---LSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHG 258
AD Q ++ + ES L +A G ++ +LL+ G V+ NG TPL A
Sbjct: 217 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 276
Query: 259 NHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIK 312
+ VK+LL+ G +T G + A G+ V +++ LL K
Sbjct: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330
Score = 34.7 bits (78), Expect = 0.11
Identities = 24/79 (30%), Positives = 34/79 (43%)
Query: 222 ACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSG 281
A G D V L G+D+N + NG L A HV V+ LL G+ T G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 282 YNSMDLAVALGYRSVQQVI 300
++ +A G V +V+
Sbjct: 98 NTALHIASLAGQAEVVKVL 116
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 75.1 bits (183), Expect = 7e-14
Identities = 40/126 (31%), Positives = 66/126 (52%)
Query: 175 INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKML 234
IN ++ G L AA G + +V+ LL G+ K +AL +A G ++VK+L
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116
Query: 235 LDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYR 294
+ G ++N NG TPL A NH+ VK LLE+GA+ + T+ G+ + +A+ G+
Sbjct: 117 VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176
Query: 295 SVQQVI 300
++
Sbjct: 177 QAVAIL 182
Score = 73.6 bits (179), Expect = 2e-13
Identities = 41/120 (34%), Positives = 65/120 (54%)
Query: 169 IEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYT 228
++ + ++N T E GFTPL AA +G + V LL GA + + L +A +G T
Sbjct: 220 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNT 279
Query: 229 DIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLA 288
++VK+LLD G ++ +G TPL A H + V++LLE GA T +G + + +A
Sbjct: 280 NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 339
Score = 72.8 bits (177), Expect = 4e-13
Identities = 58/220 (26%), Positives = 95/220 (43%), Gaps = 16/220 (7%)
Query: 88 LEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNK----HRGNEVST 143
L+VA +L + ++ G+ HV H+ K + L K H +
Sbjct: 576 LDVAKLLLQRRAAADSAGKNGLTPLHV-----AAHYDNQKVALLLLEKGASPHATAKNGY 630
Query: 144 TPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQ 203
TPL H A + +M +T + N ++G TPL A+ G +V LL
Sbjct: 631 TPL-------HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683
Query: 204 NGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKC 263
GA+ + K ++L LA + ++ +L G D + + G TPL+ A H +VK
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743
Query: 264 VKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESH 303
V LL+ GA+ +T +GY + A G+ + V+ H
Sbjct: 744 VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Score = 70.9 bits (172), Expect = 1e-12
Identities = 54/197 (27%), Positives = 88/197 (44%), Gaps = 4/197 (2%)
Query: 106 SPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQ-GEMLY 164
SP ++ YTP H + K + + T + ++ LA+Q G
Sbjct: 621 SPHATAKNGYTPL---HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDM 677
Query: 165 LATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACS 224
+ +++ I+ + + G T L AA ++ V + L ++GAD K + L +AC
Sbjct: 678 VTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACH 737
Query: 225 KGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNS 284
G +V LL G +VN NG TPL A H + +LL+ GA P T +G +
Sbjct: 738 YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797
Query: 285 MDLAVALGYRSVQQVIE 301
+ +A LGY SV ++
Sbjct: 798 LAIAKRLGYISVVDTLK 814
Score = 66.2 bits (160), Expect = 3e-11
Identities = 54/207 (26%), Positives = 88/207 (42%), Gaps = 20/207 (9%)
Query: 111 VRHVYTP--STTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEM--LYLA 166
++H+ P +TT ++P+ S R +V +L + + H LA + L++A
Sbjct: 517 LQHMAHPDAATTNGYTPLHISA------REGQVDVASVLLEAGAAHSLATKKGFTPLHVA 570
Query: 167 TR----------IEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRE 216
+ +++ + + G TPL AA + V LL+ GA P K
Sbjct: 571 AKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY 630
Query: 217 SALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTI 276
+ L +A K I LL+ G + N G TPL A H V +LL+ GA+ +
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 690
Query: 277 ETDSGYNSMDLAVALGYRSVQQVIESH 303
T SG S+ LA +V ++ H
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKH 717
Score = 62.4 bits (150), Expect = 5e-10
Identities = 40/121 (33%), Positives = 59/121 (48%)
Query: 180 EEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGV 239
E G TP+ AA G + +V LLQNGA P + E+AL +A G ++V+ LL G
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488
Query: 240 DVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQV 299
V+ TPL A + V++LL+ A P T +GY + ++ G V V
Sbjct: 489 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 548
Query: 300 I 300
+
Sbjct: 549 L 549
Score = 61.6 bits (148), Expect = 9e-10
Identities = 42/148 (28%), Positives = 70/148 (47%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A G + + ++ + T+ G T L AA GQ+ VV LL+NGA
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+ ++ L +A G T+IV++LL + NG TPL + V +LLE+GA
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVI 300
++ T G+ + +A G V +++
Sbjct: 555 AHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Score = 59.3 bits (142), Expect = 4e-09
Identities = 47/168 (27%), Positives = 76/168 (45%), Gaps = 5/168 (2%)
Query: 122 HFSPIKQSTTLTNKHRGNEVSTTPLLANSLS-VHQLAAQGEMLYLATRIEQENVINHTDE 180
H+ + +T L N RG V T N ++ +H + +G + +++ I+
Sbjct: 242 HYGNVNVATLLLN--RGAAVDFTA--RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTR 297
Query: 181 EGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVD 240
+G TPL AA G VVE LL+ GA K S L +A + + VK LL
Sbjct: 298 DGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357
Query: 241 VNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLA 288
V++ + T L A H H + K+LL+ A+P +G+ + +A
Sbjct: 358 VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 405
Score = 59.3 bits (142), Expect = 4e-09
Identities = 42/152 (27%), Positives = 69/152 (45%), Gaps = 4/152 (2%)
Query: 145 PLLA---NSLSVHQLAAQGEMLYLATRIEQENV-INHTDEEGFTPLMWAAAHGQIAVVEF 200
PLLA N LS +AAQG+ + + Q ++ + T L AA G V +
Sbjct: 324 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383
Query: 201 LLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNH 260
LL A+P + L +AC K ++++L+ G + +G TP+ A H
Sbjct: 384 LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGH 443
Query: 261 VKCVKMLLESGADPTIETDSGYNSMDLAVALG 292
+ V +LL++GA P + G ++ +A G
Sbjct: 444 LNIVLLLLQNGASPDVTNIRGETALHMAARAG 475
Score = 56.6 bits (135), Expect = 3e-08
Identities = 44/158 (27%), Positives = 75/158 (47%), Gaps = 7/158 (4%)
Query: 153 VHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
+H A G + +E+ + + G +PL AA + V+ LLQ+ A +
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 362
Query: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
+AL +A G+ + K+LLD + N NG TPL A N +K +++L++ GA
Sbjct: 363 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 422
Query: 273 DPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQN 310
T+SG + +A +G+ ++ +L LLQN
Sbjct: 423 SIQAITESGLTPIHVAAFMGHLNI-------VLLLLQN 453
Score = 53.1 bits (126), Expect = 3e-07
Identities = 35/123 (28%), Positives = 58/123 (47%)
Query: 182 GFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDV 241
GFTPL A +I V+E L++ GA Q + + + + +A G+ +IV +LL G
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 242 NEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIE 301
+ + G T L A V+ V+ LL +GA + +A LG + Q++
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517
Query: 302 SHL 304
H+
Sbjct: 518 QHM 520
Score = 52.0 bits (123), Expect = 7e-07
Identities = 32/119 (26%), Positives = 63/119 (52%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL 211
++H A +G + + + + + ++ ++G T L A+ GQ VV+ L++ GA+
Sbjct: 67 ALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 126
Query: 212 GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLES 270
+ + L +A + + D+VK LL+ G + + +G TPL A+ H + V +LLE+
Sbjct: 127 SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185
Score = 51.2 bits (121), Expect = 1e-06
Identities = 46/172 (26%), Positives = 71/172 (41%), Gaps = 37/172 (21%)
Query: 152 SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQ-- 209
++H A G++ + + +++ E TPL A+ G+ +V+ LLQ+ A P
Sbjct: 467 ALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAA 526
Query: 210 ----------------------LLGKGRESALSLACSKGYT-----------DIVKMLLD 236
LL G +A SLA KG+T D+ K+LL
Sbjct: 527 TTNGYTPLHISAREGQVDVASVLLEAG--AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584
Query: 237 CGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLA 288
+ NG TPL A H ++ K +LLE GA P +GY + +A
Sbjct: 585 RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 636
Score = 42.7 bits (99), Expect = 4e-04
Identities = 28/100 (28%), Positives = 48/100 (48%)
Query: 189 AAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNG 248
AA G + V L+ G D + +AL LA +G+ +V+ LL G V+ G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 249 GTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLA 288
T L A + VK+L++ GA+ ++ +G+ + +A
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMA 137
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/234 (25%), Positives = 87/234 (37%), Gaps = 24/234 (10%)
Query: 89 EVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTL-TNKHRGNEVSTTPLL 147
EV VL K NI+ G +Y + H +K N+ E TPL
Sbjct: 111 EVVKVLVKEGANINAQSQNGFTP--LYMAAQENHIDVVKYLLENGANQSTATEDGFTPLA 168
Query: 148 ANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAH-GQIAVVEFLLQN-- 204
QG +A +E N T + P + AA LLQN
Sbjct: 169 V-------ALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALLLQNDH 216
Query: 205 GADPQ---LLGKGRESA---LSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHG 258
AD Q ++ + ES L +A G ++ +LL+ G V+ NG TPL A
Sbjct: 217 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 276
Query: 259 NHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIK 312
+ VK+LL+ G +T G + A G+ V +++ LL K
Sbjct: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330
Score = 34.7 bits (78), Expect = 0.11
Identities = 24/79 (30%), Positives = 34/79 (43%)
Query: 222 ACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSG 281
A G D V L G+D+N + NG L A HV V+ LL G+ T G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 282 YNSMDLAVALGYRSVQQVI 300
++ +A G V +V+
Sbjct: 98 NTALHIASLAGQAEVVKVL 116
>gi|23510377 KN motif and ankyrin repeat domains 1 isoform b [Homo
sapiens]
Length = 1194
Score = 74.7 bits (182), Expect = 1e-13
Identities = 45/136 (33%), Positives = 75/136 (55%), Gaps = 6/136 (4%)
Query: 175 INHTDEEGFTPLMWAA-----AHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTD 229
++H ++ G+TP+M AA A + +VE L G + ++AL LA S G D
Sbjct: 1031 VDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRID 1090
Query: 230 IVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLL-ESGADPTIETDSGYNSMDLA 288
+VK LL CG DVN D G T L+ A HV+ VK+LL + G + +E + G ++ +A
Sbjct: 1091 MVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIA 1150
Query: 289 VALGYRSVQQVIESHL 304
+ G++ + ++ +H+
Sbjct: 1151 LEAGHKDIAVLLYAHV 1166
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,804,504
Number of Sequences: 37866
Number of extensions: 518139
Number of successful extensions: 3237
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 341
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 937
Number of HSP's gapped (non-prelim): 1593
length of query: 313
length of database: 18,247,518
effective HSP length: 102
effective length of query: 211
effective length of database: 14,385,186
effective search space: 3035274246
effective search space used: 3035274246
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.