Search of human proteins with 4502917

Search of human proteins with 4502917

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1
[Homo sapiens]
         (694 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho...  1384   0.0  
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [...  1332   0.0  
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [...   848   0.0  
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H...   848   0.0  
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]    825   0.0  
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]    598   e-171
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H...   315   7e-86
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]    308   1e-83
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p...   190   4e-48
gi|116325989 hyperpolarization activated cyclic nucleotide-gated...   186   8e-47
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ...   183   5e-46
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...   180   5e-45
gi|27886653 potassium voltage-gated channel, subfamily H, member...   163   4e-40
gi|13540549 potassium voltage-gated channel, subfamily H, member...   162   1e-39
gi|26051273 voltage-gated potassium channel, subfamily H, member...   157   2e-38
gi|4557729 voltage-gated potassium channel, subfamily H, member ...   157   2e-38
gi|4504831 potassium voltage-gated channel, subfamily H, member ...   155   9e-38
gi|6912446 potassium voltage-gated channel, subfamily H, member ...   153   6e-37
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re...   152   8e-37
gi|27886667 potassium voltage-gated channel, subfamily H, member...   151   2e-36
gi|22024390 potassium voltage-gated channel, subfamily H, member...   150   4e-36
gi|27886648 potassium voltage-gated channel, subfamily H, member...   148   2e-35
gi|27437001 potassium voltage-gated channel, subfamily H, member...   147   4e-35
gi|27886651 potassium voltage-gated channel, subfamily H, member...   143   6e-34
gi|26051271 voltage-gated potassium channel, subfamily H, member...   138   2e-32
gi|27886646 potassium voltage-gated channel, subfamily H, member...   133   6e-31
gi|27886665 potassium voltage-gated channel, subfamily H, member...    93   7e-19
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H...    44   5e-04
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho...    44   5e-04
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]      42   0.001

>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
           sapiens]
          Length = 694

 Score = 1384 bits (3582), Expect = 0.0
 Identities = 694/694 (100%), Positives = 694/694 (100%)

Query: 1   MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS 60
           MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS
Sbjct: 1   MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS 60

Query: 61  GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN 120
           GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN
Sbjct: 61  GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN 120

Query: 121 VGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVF 180
           VGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVF
Sbjct: 121 VGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVF 180

Query: 181 YNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLW 240
           YNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLW
Sbjct: 181 YNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLW 240

Query: 241 QHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNM 300
           QHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNM
Sbjct: 241 QHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNM 300

Query: 301 FRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWST 360
           FRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWST
Sbjct: 301 FRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWST 360

Query: 361 LTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSI 420
           LTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSI
Sbjct: 361 LTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSI 420

Query: 421 KQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKV 480
           KQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKV
Sbjct: 421 KQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKV 480

Query: 481 RIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVV 540
           RIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVV
Sbjct: 481 RIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVV 540

Query: 541 LSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEE 600
           LSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEE
Sbjct: 541 LSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEE 600

Query: 601 KGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQ 660
           KGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQ
Sbjct: 601 KGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQ 660

Query: 661 RLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ 694
           RLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ
Sbjct: 661 RLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ 694


>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
           [Homo sapiens]
          Length = 676

 Score = 1332 bits (3447), Expect = 0.0
 Identities = 675/694 (97%), Positives = 675/694 (97%), Gaps = 18/694 (2%)

Query: 1   MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS 60
           MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS
Sbjct: 1   MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADS 60

Query: 61  GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN 120
           GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN
Sbjct: 61  GQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN 120

Query: 121 VGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVF 180
           VGSQEPADRGR                   KKTKKKDAIVVDPSSNLYYRWLTAIALPVF
Sbjct: 121 VGSQEPADRGR------------------RKKTKKKDAIVVDPSSNLYYRWLTAIALPVF 162

Query: 181 YNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLW 240
           YNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLW
Sbjct: 163 YNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLW 222

Query: 241 QHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNM 300
           QHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNM
Sbjct: 223 QHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNM 282

Query: 301 FRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWST 360
           FRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWST
Sbjct: 283 FRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWST 342

Query: 361 LTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSI 420
           LTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSI
Sbjct: 343 LTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSI 402

Query: 421 KQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKV 480
           KQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKV
Sbjct: 403 KQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKV 462

Query: 481 RIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVV 540
           RIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVV
Sbjct: 463 RIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVV 522

Query: 541 LSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEE 600
           LSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEE
Sbjct: 523 LSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEE 582

Query: 601 KGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQ 660
           KGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQ
Sbjct: 583 KGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQ 642

Query: 661 RLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ 694
           RLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ
Sbjct: 643 RLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ 676


>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
           [Homo sapiens]
          Length = 759

 Score =  848 bits (2191), Expect = 0.0
 Identities = 425/687 (61%), Positives = 528/687 (76%), Gaps = 21/687 (3%)

Query: 4   INTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADSGQG 63
           INTQ S  +  ++ V   ++++ R ENG   + S  ++++S  +     E+       +G
Sbjct: 79  INTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSE-----ESENENPHARG 133

Query: 64  SFTGQGIA------RLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNA 117
           SF+ + +       R   L   +  +   +  ++DQ P+      +  + KE  S+  + 
Sbjct: 134 SFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEE-----KKKKKKEKKSKSDDK 188

Query: 118 QANVGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIAL 177
             N    E   + +      K        ++++K+ +KK+ +V+DPS N YY WL  I L
Sbjct: 189 NENKNDPEKKKKKKD-----KEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITL 243

Query: 178 PVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTN 237
           PV YNW ++I RACFDELQS+YL  WL+LDY +D++Y++D+ VR RTG+LEQGL+V +  
Sbjct: 244 PVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEEL 303

Query: 238 RLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNY 297
           +L   YK+  QFKLDVLSL+PTDL Y K+G NYPE+R NRLL+FSR+FEFF RTETRTNY
Sbjct: 304 KLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNY 363

Query: 298 PNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLY 357
           PN+FRI NLV+YI+IIIHWNAC++++ISK IGFG D+WVYP+I+ PE GRL+RKY+YSLY
Sbjct: 364 PNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLY 423

Query: 358 WSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKI 417
           WSTLTLTTIGETPPPV+D EY+FVVVDFL+GVLIFATIVGN+GSMISNMNA+RAEFQA+I
Sbjct: 424 WSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARI 483

Query: 418 DSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTL 477
           D+IKQYM FR V+KD+E RVI+WFDYLW NKKTVDEKEVLK LPDKL+AEIAINVHLDTL
Sbjct: 484 DAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTL 543

Query: 478 KKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQ 537
           KKVRIF DCEAGLLVELVLKL+P V+SPGDYICKKGDIG+EMYII EGKLAVVADDGVTQ
Sbjct: 544 KKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQ 603

Query: 538 FVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKA 597
           FVVLSDGSYFGEISILNIKGSK+GNRRTANI+SIGYSDLFCLSKDDLMEALTEYP+AK  
Sbjct: 604 FVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTM 663

Query: 598 LEEKGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMK 657
           LEEKG+QILMKD L+D  +A AG+DPKDLEEKV ++  S+D LQTRFAR+LAEY + Q K
Sbjct: 664 LEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQK 723

Query: 658 MKQRLSQLESQVKGGGDKPLADGEVPG 684
           +KQRL+++E  +K   D   +  E PG
Sbjct: 724 LKQRLTKVEKFLKPLIDTEFSSIEGPG 750


>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
           sapiens]
          Length = 690

 Score =  848 bits (2191), Expect = 0.0
 Identities = 425/687 (61%), Positives = 528/687 (76%), Gaps = 21/687 (3%)

Query: 4   INTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADSGQG 63
           INTQ S  +  ++ V   ++++ R ENG   + S  ++++S  +     E+       +G
Sbjct: 10  INTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSE-----ESENENPHARG 64

Query: 64  SFTGQGIA------RLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNA 117
           SF+ + +       R   L   +  +   +  ++DQ P+      +  + KE  S+  + 
Sbjct: 65  SFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEE-----KKKKKKEKKSKSDDK 119

Query: 118 QANVGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIAL 177
             N    E   + +      K        ++++K+ +KK+ +V+DPS N YY WL  I L
Sbjct: 120 NENKNDPEKKKKKKD-----KEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITL 174

Query: 178 PVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTN 237
           PV YNW ++I RACFDELQS+YL  WL+LDY +D++Y++D+ VR RTG+LEQGL+V +  
Sbjct: 175 PVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEEL 234

Query: 238 RLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNY 297
           +L   YK+  QFKLDVLSL+PTDL Y K+G NYPE+R NRLL+FSR+FEFF RTETRTNY
Sbjct: 235 KLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNY 294

Query: 298 PNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLY 357
           PN+FRI NLV+YI+IIIHWNAC++++ISK IGFG D+WVYP+I+ PE GRL+RKY+YSLY
Sbjct: 295 PNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLY 354

Query: 358 WSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKI 417
           WSTLTLTTIGETPPPV+D EY+FVVVDFL+GVLIFATIVGN+GSMISNMNA+RAEFQA+I
Sbjct: 355 WSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARI 414

Query: 418 DSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTL 477
           D+IKQYM FR V+KD+E RVI+WFDYLW NKKTVDEKEVLK LPDKL+AEIAINVHLDTL
Sbjct: 415 DAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTL 474

Query: 478 KKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQ 537
           KKVRIF DCEAGLLVELVLKL+P V+SPGDYICKKGDIG+EMYII EGKLAVVADDGVTQ
Sbjct: 475 KKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQ 534

Query: 538 FVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKA 597
           FVVLSDGSYFGEISILNIKGSK+GNRRTANI+SIGYSDLFCLSKDDLMEALTEYP+AK  
Sbjct: 535 FVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTM 594

Query: 598 LEEKGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMK 657
           LEEKG+QILMKD L+D  +A AG+DPKDLEEKV ++  S+D LQTRFAR+LAEY + Q K
Sbjct: 595 LEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQK 654

Query: 658 MKQRLSQLESQVKGGGDKPLADGEVPG 684
           +KQRL+++E  +K   D   +  E PG
Sbjct: 655 LKQRLTKVEKFLKPLIDTEFSSIEGPG 681


>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
          Length = 664

 Score =  825 bits (2130), Expect = 0.0
 Identities = 423/685 (61%), Positives = 518/685 (75%), Gaps = 43/685 (6%)

Query: 3   KINTQYSHPSRTHLK-----VKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGL 57
           K N   S P+  H       +K + +D +R     SR HS++++ +S        E + L
Sbjct: 4   KTNGVKSSPANNHNHHAPPAIKANGKDDHRTS---SRPHSAADDDTS-------SELQRL 53

Query: 58  ADSGQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNA 117
           AD         G  R+ RL+ ++R WA ++   ++  PDSF +RFRG EL+ V++QE + 
Sbjct: 54  ADVDAPQQGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDG 113

Query: 118 QANVGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKK-DAIVVDPSSNLYYRWLTAIA 176
           +   G ++  D+G                      TKKK +  V+DP+ + YY WL  IA
Sbjct: 114 K---GDKDGEDKG----------------------TKKKFELFVLDPAGDWYYCWLFVIA 148

Query: 177 LPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDT 236
           +PV YNW LL+ RACF +LQ  Y ++WLVLDY +DV+Y+ D+ +R RTGFLEQGL+V DT
Sbjct: 149 MPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQGLLVKDT 208

Query: 237 NRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTN 296
            +L  +Y  T QFKLDV S++PTDL Y  V  + PEVRFNRLL F+R+FEFFDRTETRTN
Sbjct: 209 KKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTN 268

Query: 297 YPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSL 356
           YPN+FRI NLVLYIL+IIHWNACIY+AISK IGFG D+WVYPNI+ PE+G L+R+YIY L
Sbjct: 269 YPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCL 328

Query: 357 YWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 416
           YWSTLTLTTIGETPPPVKDEEYLFV+ DFL+GVLIFATIVGNVGSMISNMNA+RAEFQAK
Sbjct: 329 YWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAK 388

Query: 417 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 476
           ID++K YMQFRKV+K +E +VIRWFDYLW NKKTVDE+E+LK+LP KL+AEIAINVHL T
Sbjct: 389 IDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLST 448

Query: 477 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 536
           LKKVRIF DCEAGLLVELVLKLRP VFSPGDYIC+KGDIGKEMYII EGKLAVVADDGVT
Sbjct: 449 LKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVT 508

Query: 537 QFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKK 596
           Q+ +LS GS FGEISILNIKGSK GNRRTANIRS+GYSDLFCLSKDDLMEA+TEYP+AKK
Sbjct: 509 QYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKK 568

Query: 597 ALEEKGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQM 656
            LEE+GR+ILMK+ L+DE       +  D++EK+ QL ++++TL TRF RLLAEY   Q 
Sbjct: 569 VLEERGREILMKEGLLDENEVATSME-VDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQ 627

Query: 657 KMKQRLSQLESQVK-GGGDKPLADG 680
           K+KQR++ LE+++K    D  L+DG
Sbjct: 628 KLKQRITVLETKMKQNNEDDYLSDG 652


>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
          Length = 575

 Score =  598 bits (1543), Expect = e-171
 Identities = 290/551 (52%), Positives = 402/551 (72%), Gaps = 9/551 (1%)

Query: 143 TSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLML 202
           T+ ++       +K   V+DPS + YY WL  +  PV YN  +L+CRACF +LQ  YL+ 
Sbjct: 9   TTESSPPAPSKARKLLPVLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVA 68

Query: 203 WLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLA 262
           WLVLDY++D+LY+LD++VR  TGFLEQG++V D  R+   Y  T  F LD+ SL+PTD+ 
Sbjct: 69  WLVLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVV 128

Query: 263 YLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYF 322
           Y+++G + P +R NR L+  RLFE FDRTETRT YPN FRI  L+LYI ++IHWN+C+YF
Sbjct: 129 YVRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYF 188

Query: 323 AISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVV 382
           A+S+++GFG D+WVYP+ + P   RL R+Y+YS Y+STL LTT+G+TPPP ++EEYLF+V
Sbjct: 189 ALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAREEEYLFMV 248

Query: 383 VDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFD 442
            DFL+ V+ FATI+G++ S+I NMN + A F      +K+YM+ + V + LE RVI W+ 
Sbjct: 249 GDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQ 308

Query: 443 YLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTV 502
           +L  NKK  +E  +L+ LP++L+AE+A++VHL TL +V+IFQ+CEA LL ELVLKL+P  
Sbjct: 309 HLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQT 368

Query: 503 FSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGN 562
           +SPG+Y+C+KGDIG+EMYII EG+LAVVADDG+TQ+ VL  G YFGEISI+NIKG+ SGN
Sbjct: 369 YSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNMSGN 428

Query: 563 RRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAG-A 621
           RRTANI+S+GYSDLFCLSK+DL E L+EYP+A+  +EEKGR+IL+K N +D     A  A
Sbjct: 429 RRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDVNAEAAEIA 488

Query: 622 DPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLADGE 681
             +  E ++  L   LD LQT+FARLLAE  ++ +K+  R+ +LE Q +        +  
Sbjct: 489 LQEATESRLRGLDQQLDDLQTKFARLLAELESSALKIAYRIERLEWQTR--------EWP 540

Query: 682 VPGDATKTEDK 692
           +P D  + +D+
Sbjct: 541 MPEDLAEADDE 551


>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
            sapiens]
          Length = 1251

 Score =  315 bits (808), Expect = 7e-86
 Identities = 165/458 (36%), Positives = 272/458 (59%), Gaps = 15/458 (3%)

Query: 161  VDPSSNLYY-RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVL 219
            +DP +NL Y  WL  + +   +N +L+  R  F     + +  WL++DY  D++Y LD+ 
Sbjct: 648  IDPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDIT 707

Query: 220  V-RARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRL 278
            V + R  F+  G +++D   +  +Y  + +FK+D+LSL+P D  YLKVG N P +R  R 
Sbjct: 708  VFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN-PLLRLPRC 766

Query: 279  LKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYP 338
            LK+   FEF  R E+  +   ++R+     Y+L  +H N+C+Y+  S + G G+  WVY 
Sbjct: 767  LKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYD 826

Query: 339  NISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGN 398
             +           YI   Y++  TL TIG  P P    E +F ++++  GV  F+ ++G 
Sbjct: 827  GVG--------NSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQ 878

Query: 399  VGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLK 458
            +  ++    A +  +++ +DS  +YM F K+ K ++ RV  W++Y W ++  +DE E++ 
Sbjct: 879  MRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMV 938

Query: 459  SLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKE 518
             LPDK++ ++AI+V+ + + KV +FQ C+  ++ +++ +LR  V+ P DY+CKKG+IG+E
Sbjct: 939  QLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGRE 998

Query: 519  MYIINEGKLAVV-ADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLF 577
            MYII  G++ V+   DG +  V L  GS FGEIS+L + G   GNRRTAN+ + G+++LF
Sbjct: 999  MYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTANVVAHGFTNLF 1055

Query: 578  CLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEE 615
             L K DL E L  YPE++K L +K R++L  +N   EE
Sbjct: 1056 ILDKKDLNEILVHYPESQKLLRKKARRMLRSNNKPKEE 1093


>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
          Length = 809

 Score =  308 bits (789), Expect = 1e-83
 Identities = 186/559 (33%), Positives = 311/559 (55%), Gaps = 39/559 (6%)

Query: 147 TEEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVL 206
           TE  K+ K  ++I    +  LY  WL  + L   +N   +  R  F    ++ +  WL+ 
Sbjct: 198 TEYLKRIKLPNSID-SYTDRLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIA 256

Query: 207 DYSADVLYVLDVL-VRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLK 265
           D   D++Y+ D+L ++ R  F+  G ++ D+N L +HY+T+T+F+LDV S++P D+ YL 
Sbjct: 257 DIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLF 316

Query: 266 VGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAIS 325
            G N P  R NR+LK++  FEF    E+  +   ++R+     Y+L I+H NAC+Y+  S
Sbjct: 317 FGFN-PMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWAS 375

Query: 326 KFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDF 385
            + G GT  WVY             +Y+   YW+  TL TIG  P P    E +F +++F
Sbjct: 376 NYEGIGTTRWVYDGEG--------NEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNF 427

Query: 386 LVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLW 445
             GV +F++++G +  +I    A++  F+A +D    YM    + K ++ RV  W++Y W
Sbjct: 428 FSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTW 487

Query: 446 ANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSP 505
            +++ +DE ++LK+LP  ++  +AI+V+   + KV +F+ C+  ++ +++L+L+  ++ P
Sbjct: 488 DSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLP 547

Query: 506 GDYICKKGDIGKEMYIINEGKLAVV-ADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRR 564
           GD++CKKG+IGKEMYII  G++ V+   DG    V L  GS FGEIS+L   G   GNRR
Sbjct: 548 GDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGG---GNRR 604

Query: 565 TANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPK 624
           TAN+ + G+++L  L K  L E L  YP++++ L +K R +L +      + A A    K
Sbjct: 605 TANVVAHGFANLLTLDKKTLQEILVHYPDSERILMKKARVLLKQ----KAKTAEATPPRK 660

Query: 625 DL------EEKVEQLGSSL--DTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKP 676
           DL      +E+  +L  +L   T +   ARLL        K+K+  +  + +   GG++ 
Sbjct: 661 DLALLFPPKEETPKLFKTLLGGTGKASLARLL--------KLKREQAAQKKENSEGGEE- 711

Query: 677 LADGEVPGDATK-TEDKQQ 694
             +G+   D  K  EDKQ+
Sbjct: 712 --EGKENEDKQKENEDKQK 728


>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 4 [Homo sapiens]
          Length = 1203

 Score =  190 bits (482), Expect = 4e-48
 Identities = 134/477 (28%), Positives = 236/477 (49%), Gaps = 41/477 (8%)

Query: 149 EEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDY 208
           E+++ K     ++ P S+  + W   + L +  N  L+I        + E    W+V + 
Sbjct: 243 EQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGN--LIIIPVGITFFKDENTTPWIVFNV 300

Query: 209 SADVLYVLDVLVRARTGFL--EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKV 266
            +D  +++D+++  RTG +  +   ++ D  R+   Y   + F +D +S +P D  +L V
Sbjct: 301 VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKY-LKSWFMVDFISSIPVDYIFLIV 359

Query: 267 GTNYPE-----------VRFN------RLLKFSRLFEFFDRTE-----TRTNYPNMFRIG 304
            T               VRF       RLL+ SRL  +  + E     T      + RI 
Sbjct: 360 ETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIV 419

Query: 305 NLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLT 364
           NL+  +L++ HW+ C+ F +     F  D WV  N  +  +    ++Y Y+L+ +   + 
Sbjct: 420 NLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMV--NNSWGKQYSYALFKAMSHML 477

Query: 365 TIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQY 423
            IG     PV   +    ++  +VG   +A  +G+  ++I ++++SR ++Q K   ++QY
Sbjct: 478 CIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQY 537

Query: 424 MQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTL-KKVRI 482
           M F K+  D   R+  ++++ +   K  DE+ +L  L + L+ EI IN +   L   + +
Sbjct: 538 MSFHKLPPDTRQRIHDYYEHRYQG-KMFDEESILGELSEPLREEI-INFNCRKLVASMPL 595

Query: 483 FQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLS 542
           F + +   +  ++ KLR  VF PGDYI ++G IGK+MY I  G ++V+      +   L+
Sbjct: 596 FANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKETKLA 653

Query: 543 DGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALE 599
           DGSYFGEI +L      +  RRTA++R+  Y  L+ LS D+  E L EYP  ++A E
Sbjct: 654 DGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFE 704


>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 1 [Homo sapiens]
          Length = 890

 Score =  186 bits (471), Expect = 8e-47
 Identities = 129/477 (27%), Positives = 237/477 (49%), Gaps = 39/477 (8%)

Query: 148 EEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLD 207
           +E+++ K     ++ P S+  + W   + + +  N  ++     F   Q+     W++ +
Sbjct: 122 KEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTT--TPWIIFN 179

Query: 208 YSADVLYVLDVLVRARTGFLEQGL--MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLK 265
            ++D +++LD+++  RTG + +    ++ D   +  +Y   + F +D +S +P D  +L 
Sbjct: 180 VASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNY-LKSWFVVDFISSIPVDYIFLI 238

Query: 266 VGTNYPE-----------VRFN------RLLKFSRLFEFFDRTE-----TRTNYPNMFRI 303
           V                 VRF       RLL+ SRL  +  + E     T      + RI
Sbjct: 239 VEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRI 298

Query: 304 GNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTL 363
            NL+  +L++ HW+ C+ F +     F  D WV  N  + +     ++Y Y+L+ +   +
Sbjct: 299 FNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSW--GKQYSYALFKAMSHM 356

Query: 364 TTIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQ 422
             IG     PV   +    ++  +VG   +A  VG+  ++I ++++SR ++Q K   ++Q
Sbjct: 357 LCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQ 416

Query: 423 YMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRI 482
           YM F K+  D+  ++  ++++ +   K  DE+ +L  L D L+ EI        +  + +
Sbjct: 417 YMSFHKLPADMRQKIHDYYEHRYQG-KIFDEENILNELNDPLREEIVNFNCRKLVATMPL 475

Query: 483 FQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLS 542
           F + +   +  ++ KLR  VF PGDYI ++G +GK+MY I  G   V+     ++ + L+
Sbjct: 476 FANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKS--SKEMKLT 533

Query: 543 DGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALE 599
           DGSYFGEI +L  KG     RRTA++R+  Y  L+ LS D+  E L EYP  ++A E
Sbjct: 534 DGSYFGEICLLT-KG-----RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFE 584


>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 3 [Homo sapiens]
          Length = 774

 Score =  183 bits (464), Expect = 5e-46
 Identities = 133/501 (26%), Positives = 239/501 (47%), Gaps = 39/501 (7%)

Query: 149 EEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDY 208
           E+++ K   A ++ P S+  + W   + L +  N  +L     F   + E    W+V + 
Sbjct: 74  EQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITF--FKEENSPPWIVFNV 131

Query: 209 SADVLYVLDVLVRARTGFL-EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL--- 264
            +D  ++LD+++  RTG + E+G  +    R  +     T F +D++S +P D  +L   
Sbjct: 132 LSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVE 191

Query: 265 ----------KVGTNYPEVRFN------RLLKFSRLFEFFDRTE-----TRTNYPNMFRI 303
                     K       VRF       RLL+ SRL  +  + E     T      + RI
Sbjct: 192 LEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRI 251

Query: 304 GNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTL 363
            NL+  +L++ HW+ C+ F +     F  D WV  N  +  +    R+Y ++L+ +   +
Sbjct: 252 FNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMV--NHSWGRQYSHALFKAMSHM 309

Query: 364 TTIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQ 422
             IG     PV   +    ++  +VG   +A  +G+  ++I ++++SR ++Q K   ++Q
Sbjct: 310 LCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQ 369

Query: 423 YMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRI 482
           YM F K+  D   R+  ++++ +   K  DE+ +L  L + L+ EI        +  + +
Sbjct: 370 YMSFHKLPADTRQRIHEYYEHRYQG-KMFDEESILGELSEPLREEIINFTCRGLVAHMPL 428

Query: 483 FQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLS 542
           F   +   +  ++ KLR  VF PGD + ++G +G++MY I  G L+V+A     +   L+
Sbjct: 429 FAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARG--ARDTRLT 486

Query: 543 DGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKG 602
           DGSYFGEI +L      +  RRTA++R+  Y  L+ LS D     L E+P  ++A E   
Sbjct: 487 DGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVA 540

Query: 603 RQILMKDNLIDEELARAGADP 623
              L++    +  L R  ++P
Sbjct: 541 MDRLLRIGKKNSILQRKRSEP 561


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score =  180 bits (456), Expect = 5e-45
 Identities = 128/476 (26%), Positives = 231/476 (48%), Gaps = 39/476 (8%)

Query: 149 EEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDY 208
           E+++ K   A ++ P S+  + W   + L +  N  L+I        + E    W+V + 
Sbjct: 192 EQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGN--LIIIPVGITFFKDETTAPWIVFNV 249

Query: 209 SADVLYVLDVLVRARTGFL--EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKV 266
            +D  +++D+++  RTG +  +   ++ D  ++ + Y   T F +D +S +P D  +L V
Sbjct: 250 VSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKY-LRTWFVVDFVSSIPVDYIFLIV 308

Query: 267 GTNYPE-----------VRFN------RLLKFSRLFEFFDRTE-----TRTNYPNMFRIG 304
                            VRF       RLL+ SRL  +  + E     T      + RI 
Sbjct: 309 EKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRIC 368

Query: 305 NLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLT 364
           NL+  +L++ HW+ C+ F +     F  + WV  N  +  +   S  Y ++L+ +   + 
Sbjct: 369 NLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMV--NHSWSELYSFALFKAMSHML 426

Query: 365 TIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQY 423
            IG     P    +    ++  +VG   +A  +G+  ++I ++++SR ++Q K   ++QY
Sbjct: 427 CIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQY 486

Query: 424 MQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIF 483
           M F K+  D   ++  ++++ +   K  DE  +L  L   L+ EI        +  + +F
Sbjct: 487 MSFHKLPADFRQKIHDYYEHRYQG-KMFDEDSILGELNGPLREEIVNFNCRKLVASMPLF 545

Query: 484 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 543
            + +   +  ++ KL+  VF PGDYI ++G IGK+MY I  G ++V+      + + LSD
Sbjct: 546 ANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKEMKLSD 603

Query: 544 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALE 599
           GSYFGEI +L      +  RRTA++R+  Y  L+ LS D+  E L EYP  ++A E
Sbjct: 604 GSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFE 653


>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
           isoform 1 [Homo sapiens]
          Length = 1196

 Score =  163 bits (413), Expect = 4e-40
 Identities = 112/409 (27%), Positives = 203/409 (49%), Gaps = 31/409 (7%)

Query: 205 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 263
           V+D   D+++++D+L+  RT ++ Q   +VSD  ++  HY     F +D+++ +P DL  
Sbjct: 453 VVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHY-FKGWFLIDMVAAIPFDLLI 511

Query: 264 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 318
              G++        LLK +RL            Y      G  VL +L     +I HW A
Sbjct: 512 FGSGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLMLLMCIFALIAHWLA 567

Query: 319 CIYFAISKFIG-FGTDS--WV----------YPNISIPEHGRLSRKYIYSLYWSTLTLTT 365
           CI++AI      + TD   W+          Y +        +  KY+ +LY++  +LT+
Sbjct: 568 CIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTS 627

Query: 366 IG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYM 424
           +G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  +K+++
Sbjct: 628 VGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFI 687

Query: 425 QFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQ 484
           +F ++   L  R+  +F + W     +D   VLK  P+ L+A+I ++++   L+  + F+
Sbjct: 688 RFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFR 747

Query: 485 DCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDG 544
               G L  L +K + T   PGD +   GD+   +Y ++ G + ++ DD V    +L   
Sbjct: 748 GASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVV--AILGKN 805

Query: 545 SYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 593
             FGE+  L  K  KS     A++R++ Y DL  + ++DL+E L  YPE
Sbjct: 806 DIFGEMVHLYAKPGKS----NADVRALTYCDLHKIQREDLLEVLDMYPE 850


>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
           isoform 1 [Homo sapiens]
          Length = 994

 Score =  162 bits (410), Expect = 1e-39
 Identities = 114/408 (27%), Positives = 202/408 (49%), Gaps = 31/408 (7%)

Query: 205 VLDYSADVLYVLDVLVRARTGFLEQG-LMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 263
           V+D   D+++V+D+++  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHY-FKGWFLIDMVAAIPFDLLI 360

Query: 264 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 318
            + G++        LLK +RL            Y      G  VL++L     +I HW A
Sbjct: 361 FRTGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 416

Query: 319 CIYFAISKF--------IGF----GTDSWVYPNISIPEHG-RLSRKYIYSLYWSTLTLTT 365
           CI++AI           IG+    G       N S P  G  +  KY+ +LY++  +LT+
Sbjct: 417 CIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTS 476

Query: 366 IG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYM 424
           +G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  +K+++
Sbjct: 477 VGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFI 536

Query: 425 QFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQ 484
           +F ++   L  R+  +F + W+    +D   VLK  P+ L+A+I +++H   L+    F 
Sbjct: 537 RFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFS 596

Query: 485 DCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDG 544
               G L  L +K + T   PGD +   GD+   +Y I+ G + ++ DD V    +L   
Sbjct: 597 GAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGKN 654

Query: 545 SYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYP 592
             FGE   L+ +  KS    +A++R++ Y DL  + + DL+E L  YP
Sbjct: 655 DIFGEPVSLHAQPGKS----SADVRALTYCDLHKIQRADLLEVLDMYP 698


>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
           isoform c [Homo sapiens]
          Length = 819

 Score =  157 bits (398), Expect = 2e-38
 Identities = 110/408 (26%), Positives = 200/408 (49%), Gaps = 33/408 (8%)

Query: 205 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 263
           V+D   D+++++D+L+  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 114 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHY-FKGWFLIDMVAAIPFDLLI 172

Query: 264 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 318
              G+         LLK +RL            Y      G  VL++L     +I HW A
Sbjct: 173 FGSGSE----ELIGLLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 225

Query: 319 CIYFAISKFIGFGTDS---WVY---PNISIPEHGR------LSRKYIYSLYWSTLTLTTI 366
           CI++AI        DS   W++     I  P +        +  KY+ +LY++  +LT++
Sbjct: 226 CIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSV 285

Query: 367 G-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQ 425
           G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  ++++++
Sbjct: 286 GFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIR 345

Query: 426 FRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQD 485
           F ++   L  R+  +F + W+    +D   VLK  P+ L+A+I ++++   L+  + F+ 
Sbjct: 346 FHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRG 405

Query: 486 CEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGS 545
              G L  L +K + T   PGD +   GD+   +Y I+ G + ++  D V    +L    
Sbjct: 406 ATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGKND 463

Query: 546 YFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 593
            FGE   L  +  KS      ++R++ Y DL  + +DDL+E L  YPE
Sbjct: 464 IFGEPLNLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 507


>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
           isoform a [Homo sapiens]
          Length = 1159

 Score =  157 bits (398), Expect = 2e-38
 Identities = 110/408 (26%), Positives = 200/408 (49%), Gaps = 33/408 (8%)

Query: 205 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 263
           V+D   D+++++D+L+  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHY-FKGWFLIDMVAAIPFDLLI 512

Query: 264 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 318
              G+         LLK +RL            Y      G  VL++L     +I HW A
Sbjct: 513 FGSGSE----ELIGLLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 565

Query: 319 CIYFAISKFIGFGTDS---WVY---PNISIPEHGR------LSRKYIYSLYWSTLTLTTI 366
           CI++AI        DS   W++     I  P +        +  KY+ +LY++  +LT++
Sbjct: 566 CIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSV 625

Query: 367 G-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQ 425
           G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  ++++++
Sbjct: 626 GFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIR 685

Query: 426 FRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQD 485
           F ++   L  R+  +F + W+    +D   VLK  P+ L+A+I ++++   L+  + F+ 
Sbjct: 686 FHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRG 745

Query: 486 CEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGS 545
              G L  L +K + T   PGD +   GD+   +Y I+ G + ++  D V    +L    
Sbjct: 746 ATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGKND 803

Query: 546 YFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 593
            FGE   L  +  KS      ++R++ Y DL  + +DDL+E L  YPE
Sbjct: 804 IFGEPLNLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 847


>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
           isoform 2 [Homo sapiens]
          Length = 962

 Score =  155 bits (393), Expect = 9e-38
 Identities = 132/515 (25%), Positives = 239/515 (46%), Gaps = 61/515 (11%)

Query: 155 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 209
           K++A    P   L+Y      W   I +  FY   L+     F   Q+   + WLV+D  
Sbjct: 199 KQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSI 256

Query: 210 ADVLYVLDVLVRARTGFL-EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL---- 264
            DV++++D+++   T F+   G ++SD   +  +Y   T F +D+LS +P D+       
Sbjct: 257 VDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNY-LKTWFVIDLLSCLPYDVINAFENV 315

Query: 265 --KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWN 317
              + + +  ++  RLL+  R+    D         +    G  VL +L+ +     HW 
Sbjct: 316 DEGISSLFSSLKVVRLLRLGRVARKLD---------HYIEYGAAVLVLLVCVFGLAAHWM 366

Query: 318 ACIYFAISKFIGFGTD-------SWVYP---NISIPE--HGRLSRK----------YIYS 355
           ACI+++I  +  F  D       SW+Y    +I  P   +G  S K          YI S
Sbjct: 367 ACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISS 426

Query: 356 LYWSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQ 414
           LY++  +LT++G     P  D E +F V   ++G L++ATI GNV ++   M A+   + 
Sbjct: 427 LYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYH 486

Query: 415 AKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHL 474
             ++S++ +++  +V K L  RV+ +    W+  + +D ++VL+  P  ++A+I ++++ 
Sbjct: 487 EMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNR 546

Query: 475 DTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDG 534
              K+   F+    G L  L ++ +    +PGD I   G+    +  +  G L V+ DD 
Sbjct: 547 KVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDE 606

Query: 535 VTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEA 594
           V    +L  G  FG++       ++S     AN+R++ Y DL  + +D L + L  Y   
Sbjct: 607 VV--AILGKGDVFGDVFWKEATLAQS----CANVRALTYCDLHVIKRDALQKVLEFYTAF 660

Query: 595 KKALEEKGRQILMKDNLIDEELARAGADPKDLEEK 629
             +     R +++  NL    + R  +D K  EE+
Sbjct: 661 SHSF---SRNLILTYNLRKRIVFRKISDVKREEEE 692


>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
           [Homo sapiens]
          Length = 1017

 Score =  153 bits (386), Expect = 6e-37
 Identities = 127/499 (25%), Positives = 238/499 (47%), Gaps = 39/499 (7%)

Query: 171 WLTAIALPVFYNWYLLICRACF--DELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLE 228
           W   I L  FY    +    CF  D+         LV D + ++L++LD+++  RT ++ 
Sbjct: 229 WDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVS 288

Query: 229 Q-GLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEF 287
           Q G ++S    +  HY   T F +D+++ +P DL Y+   T    V   + ++  RL   
Sbjct: 289 QSGQVISAPRSIGLHY-LATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRL 347

Query: 288 FDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTD------SWV----- 336
             + E R +  +   +  L+    ++ HW ACI++ I +      D       W+     
Sbjct: 348 LQKLE-RYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGK 406

Query: 337 -----YPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVK-DEEYLFVVVDFLVGVL 390
                Y N S+    R S  YI +LY++  +LT++G        D E +F +   L+G L
Sbjct: 407 RLEVPYVNGSVGGPSRRSA-YIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGAL 465

Query: 391 IFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKT 450
           + A + GNV ++I  M + R+ + +++  +K +++  ++ + L+ R++ +F   WA    
Sbjct: 466 MHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSG 525

Query: 451 VDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYIC 510
           +D  E+L+  PD+L+A+IA++++ + L ++ +F     G L  L L ++ +  +PG+Y+ 
Sbjct: 526 IDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLL 584

Query: 511 KKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSG--------N 562
           ++GD  +  Y +  G L V+ D+ V    +L  G   G  + +   G + G         
Sbjct: 585 RRGDALQAHYYVCSGSLEVLRDNMV--LAILGKGDLIG--ADIPEPGQEPGLGADPNFVL 640

Query: 563 RRTANIRSIGYSDLFCLSKDDLMEALTEYPE---AKKALEEKGRQILMKDNLIDEELARA 619
           + +A+++++ Y  L  LS   L E L  YPE   A +A   +     ++       L+R 
Sbjct: 641 KTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRF 700

Query: 620 GADPKDLEEKVEQLGSSLD 638
              P+  + + E LGSS D
Sbjct: 701 SRSPRLSQPRSESLGSSSD 719


>gi|38569493 potassium voltage-gated channel, subfamily H
           (eag-related), member 3 [Homo sapiens]
          Length = 1083

 Score =  152 bits (385), Expect = 8e-37
 Identities = 114/434 (26%), Positives = 201/434 (46%), Gaps = 54/434 (12%)

Query: 205 VLDYSADVLYVLDVLVRARTGFLEQ-GLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 263
           V D + +VL++LD+++  RT F+ + G +V     +  HY  TT F LDV++ +P DL +
Sbjct: 263 VCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHY-VTTWFLLDVIAALPFDLLH 321

Query: 264 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFA 323
                 Y      + ++  RL     R +  + Y  +  +  L+    ++ HW AC++F 
Sbjct: 322 AFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVV-LTLLMAVFALLAHWVACVWFY 380

Query: 324 ISKF-----------IGF---------------------GTDSWVYPNISIPEHGR---- 347
           I +            IG+                     G  S    N S          
Sbjct: 381 IGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGL 440

Query: 348 -------LSRKYIYSLYWSTLTLTTIGETPPPVK-DEEYLFVVVDFLVGVLIFATIVGNV 399
                  L   YI SLY++  +LT++G        D E +F +   L+G L+ A + GNV
Sbjct: 441 ELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNV 500

Query: 400 GSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKS 459
            ++I  M A R  + ++   ++ Y++  ++ K L+ R++ +F   WA    +D  E+L+S
Sbjct: 501 TAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQS 560

Query: 460 LPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEM 519
           LPD+L+A+IA+++H + L ++ +F+    G L  L L LRP   +PG+Y+  +GD  + +
Sbjct: 561 LPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQAL 619

Query: 520 YIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCL 579
           Y +  G + V+   G T   +L  G   G      +   +   +  A+++ + Y  L CL
Sbjct: 620 YFVCSGSMEVL--KGGTVLAILGKGDLIG----CELPRREQVVKANADVKGLTYCVLQCL 673

Query: 580 SKDDLMEALTEYPE 593
               L ++L  YPE
Sbjct: 674 QLAGLHDSLALYPE 687


>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
           [Homo sapiens]
          Length = 1107

 Score =  151 bits (381), Expect = 2e-36
 Identities = 110/468 (23%), Positives = 222/468 (47%), Gaps = 33/468 (7%)

Query: 155 KKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACF---DELQSEYLMLWLVLDYSAD 211
           KK   ++   S     W   I L  FY    +    CF   D+L +       V D + +
Sbjct: 208 KKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRSTT--VSDIAVE 265

Query: 212 VLYVLDVLVRARTGFLEQ-GLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNY 270
           +L+++D+++  RT ++ + G ++ +   +  HY  TT F +D+++ +P DL Y    T  
Sbjct: 266 ILFIIDIILNFRTTYVSKSGQVIFEARSICIHY-VTTWFIIDLIAALPFDLLYAFNVTVV 324

Query: 271 PEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGF 330
             V   + ++  RL     + +  + +  +  +  L+    ++ HW ACI++ I K    
Sbjct: 325 SLVHLLKTVRLLRLLRLLQKLDRYSQHSTIV-LTLLMSMFALLAHWMACIWYVIGKMERE 383

Query: 331 GTD------SWVYP---NISIPEHGR-------LSRKYIYSLYWSTLTLTTIGETPPPVK 374
                     W++     +  P +G        +   YI +LY++  +LT++G       
Sbjct: 384 DNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSAN 443

Query: 375 -DEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDL 433
            D E +F +   L+G L+ A + GNV ++I  M +  + +  +   +K +++   + + L
Sbjct: 444 TDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQL 503

Query: 434 ETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVE 493
           + R++ +F   W+    +D  E+LK  PD+L+++I ++++ + L ++ +F+    G L  
Sbjct: 504 KQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEIL-QLSLFECASRGCLRS 562

Query: 494 LVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISIL 553
           L L ++ +  +PG+Y+ ++GD  + +Y +  G + V+ D  V    +L  G   G     
Sbjct: 563 LSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMV--LAILGKGDLIG----A 616

Query: 554 NIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE-AKKALEE 600
           N+       +  A+++++ Y DL C+    L E L  YPE A K +E+
Sbjct: 617 NLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVED 664


>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
           isoform 1 [Homo sapiens]
          Length = 988

 Score =  150 bits (379), Expect = 4e-36
 Identities = 128/513 (24%), Positives = 228/513 (44%), Gaps = 58/513 (11%)

Query: 155 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 209
           K++A    P   L+Y      W   I +  FY   ++     F   Q+   + WLVLD  
Sbjct: 196 KQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSV 253

Query: 210 ADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL----- 264
            DV++++D+++   T F+  G  V    +L +     T F +D+LS +P D+        
Sbjct: 254 VDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVD 313

Query: 265 -KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWNA 318
             + + +  ++  RLL+  R+    D         +    G  VL +L+ +     HW A
Sbjct: 314 EGISSLFSSLKVVRLLRLGRVARKLD---------HYLEYGAAVLVLLVCVFGLVAHWLA 364

Query: 319 CIYFAISKFIGFGT-------DSWVYP---NISIPEHGRLSRK-----------YIYSLY 357
           CI+++I  +            DSW+Y    +I  P     S             Y+ SLY
Sbjct: 365 CIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLY 424

Query: 358 WSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 416
           ++  +LTTIG     P  D E +F V   +VG L++ATI GNV ++   M A+   +   
Sbjct: 425 FTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEM 484

Query: 417 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 476
           +++++ +++  +V K L  RV+ +    W+  K +D ++VL   P  ++A+I ++++   
Sbjct: 485 LNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKV 544

Query: 477 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 536
             +   F+    G L  L ++ +    +PGD I   G+    +  +  G L V+ DD V 
Sbjct: 545 FNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV 604

Query: 537 QFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKK 596
              +L  G  FG+I         +     AN+R++ Y DL  + ++ L++ L  Y     
Sbjct: 605 --AILGKGDVFGDI----FWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFAN 658

Query: 597 ALEEKGRQILMKDNLIDEELARAGADPKDLEEK 629
           +     R + +  NL    + R  +D K  EE+
Sbjct: 659 SF---SRNLTLTCNLRKRIIFRKISDVKKEEEE 688


>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
           isoform 2 [Homo sapiens]
          Length = 624

 Score =  148 bits (373), Expect = 2e-35
 Identities = 120/475 (25%), Positives = 214/475 (45%), Gaps = 55/475 (11%)

Query: 155 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 209
           K++A    P   L+Y      W   I +  FY   ++     F   Q+   + WLVLD  
Sbjct: 138 KQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSV 195

Query: 210 ADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL----- 264
            DV++++D+++   T F+  G  V    +L +     T F +D+LS +P D+        
Sbjct: 196 VDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVD 255

Query: 265 -KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWNA 318
             + + +  ++  RLL+  R+    D         +    G  VL +L+ +     HW A
Sbjct: 256 EGISSLFSSLKVVRLLRLGRVARKLD---------HYLEYGAAVLVLLVCVFGLVAHWLA 306

Query: 319 CIYFAISKFIGFGT-------DSWVYP---NISIPEHGRLSRK-----------YIYSLY 357
           CI+++I  +            DSW+Y    +I  P     S             Y+ SLY
Sbjct: 307 CIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLY 366

Query: 358 WSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 416
           ++  +LTTIG     P  D E +F V   +VG L++ATI GNV ++   M A+   +   
Sbjct: 367 FTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEM 426

Query: 417 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 476
           +++++ +++  +V K L  RV+ +    W+  K +D ++VL   P  ++A+I ++++   
Sbjct: 427 LNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKV 486

Query: 477 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 536
             +   F+    G L  L ++ +    +PGD I   G+    +  +  G L V+ DD V 
Sbjct: 487 FNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV 546

Query: 537 QFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEY 591
              +L  G  FG+I         +     AN+R++ Y DL  + ++ L++ L  Y
Sbjct: 547 --AILGKGDVFGDI----FWKETTLAHACANVRALTYCDLHIIKREALLKVLDFY 595


>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
           isoform 1 [Homo sapiens]
          Length = 989

 Score =  147 bits (370), Expect = 4e-35
 Identities = 135/542 (24%), Positives = 244/542 (45%), Gaps = 88/542 (16%)

Query: 155 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 209
           K++A    P   L+Y      W   I +  FY   L+     F   Q+   + WLV+D  
Sbjct: 199 KQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSI 256

Query: 210 ADVLYVLDVLVRARTGFL-EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDL------- 261
            DV++++D+++   T F+   G ++SD   +  +Y   T F +D+LS +P D+       
Sbjct: 257 VDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNY-LKTWFVIDLLSCLPYDVINAFENV 315

Query: 262 ----AYL----KVG------------------TNYPEVRFNRLLKFSRLFEFFDRTETRT 295
               A++    K+G                  + +  ++  RLL+  R+    D      
Sbjct: 316 DEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLD------ 369

Query: 296 NYPNMFRIGNLVLYILIII-----HWNACIYFAISKFIGFGTD-------SWVYP---NI 340
              +    G  VL +L+ +     HW ACI+++I  +  F  D       SW+Y    +I
Sbjct: 370 ---HYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDI 426

Query: 341 SIPE--HGRLSRK----------YIYSLYWSTLTLTTIG-ETPPPVKDEEYLFVVVDFLV 387
             P   +G  S K          YI SLY++  +LT++G     P  D E +F V   ++
Sbjct: 427 GTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMI 486

Query: 388 GVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWAN 447
           G L++ATI GNV ++   M A+   +   ++S++ +++  +V K L  RV+ +    W+ 
Sbjct: 487 GSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSM 546

Query: 448 KKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGD 507
            + +D ++VL+  P  ++A+I ++++    K+   F+    G L  L ++ +    +PGD
Sbjct: 547 SRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGD 606

Query: 508 YICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTAN 567
            I   G+    +  +  G L V+ DD V    +L  G  FG++       ++S     AN
Sbjct: 607 LIYHAGESVDSLCFVVSGSLEVIQDDEVV--AILGKGDVFGDVFWKEATLAQS----CAN 660

Query: 568 IRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPKDLE 627
           +R++ Y DL  + +D L + L  Y     +     R +++  NL    + R  +D K  E
Sbjct: 661 VRALTYCDLHVIKRDALQKVLEFYTAFSHSF---SRNLILTYNLRKRIVFRKISDVKREE 717

Query: 628 EK 629
           E+
Sbjct: 718 EE 719


>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
           isoform 2 [Homo sapiens]
          Length = 905

 Score =  143 bits (360), Expect = 6e-34
 Identities = 104/394 (26%), Positives = 183/394 (46%), Gaps = 56/394 (14%)

Query: 205 VLDYSADVLYVLDVLVRARTGFLEQG-LMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 263
           V+D   D+++V+D+++  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHY-FKGWFLIDMVAAIPFDLLI 360

Query: 264 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 318
            + G++        LLK +RL            Y      G  VL++L     +I HW A
Sbjct: 361 FRTGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 416

Query: 319 CIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEY 378
           CI    S  +GFG       N+S                              P  + E 
Sbjct: 417 CICSLTS--VGFG-------NVS------------------------------PNTNSEK 437

Query: 379 LFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVI 438
           +F +   L+G L++A+I GNV ++I  + +  A +  ++  +K++++F ++   L  R+ 
Sbjct: 438 VFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLE 497

Query: 439 RWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKL 498
            +F + W+    +D   VLK  P+ L+A+I +++H   L+    F     G L  L +K 
Sbjct: 498 EYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKF 557

Query: 499 RPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGS 558
           + T   PGD +   GD+   +Y I+ G + ++ DD V    +L     FGE   L+ +  
Sbjct: 558 KTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGKNDIFGEPVSLHAQPG 615

Query: 559 KSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYP 592
           KS    +A++R++ Y DL  + + DL+E L  YP
Sbjct: 616 KS----SADVRALTYCDLHKIQRADLLEVLDMYP 645


>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
           isoform b [Homo sapiens]
          Length = 888

 Score =  138 bits (347), Expect = 2e-32
 Identities = 100/394 (25%), Positives = 189/394 (47%), Gaps = 31/394 (7%)

Query: 205 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 263
           V+D   D+++++D+L+  RT ++     +VS   R+  HY     F +D+++ +P DL  
Sbjct: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHY-FKGWFLIDMVAAIPFDLLI 512

Query: 264 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 318
              G+         LLK +RL            Y      G  VL++L     +I HW A
Sbjct: 513 FGSGSE----ELIGLLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 565

Query: 319 CIYFAISKFIGFGTDS---WVY---PNISIPEHGR------LSRKYIYSLYWSTLTLTTI 366
           CI++AI        DS   W++     I  P +        +  KY+ +LY++  +LT++
Sbjct: 566 CIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSV 625

Query: 367 G-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQ 425
           G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  ++++++
Sbjct: 626 GFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIR 685

Query: 426 FRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQD 485
           F ++   L  R+  +F + W+    +D   VLK  P+ L+A+I ++++   L+  + F+ 
Sbjct: 686 FHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRG 745

Query: 486 CEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGS 545
              G L  L +K + T   PGD +   GD+   +Y I+ G + ++  D V   + +  G+
Sbjct: 746 ATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGMGWGA 805

Query: 546 YFGEISILNIKGSKSGNRRTANIRSIGYSDLFCL 579
             G    L +  + S      N++S+G     CL
Sbjct: 806 GTG----LEMPSAASRGASLLNMQSLGLWTWDCL 835


>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
           isoform 3 [Homo sapiens]
          Length = 611

 Score =  133 bits (334), Expect = 6e-31
 Identities = 106/419 (25%), Positives = 189/419 (45%), Gaps = 49/419 (11%)

Query: 155 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 209
           K++A    P   L+Y      W   I +  FY   ++     F   Q+   + WLVLD  
Sbjct: 196 KQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSV 253

Query: 210 ADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL----- 264
            DV++++D+++   T F+  G  V    +L +     T F +D+LS +P D+        
Sbjct: 254 VDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVD 313

Query: 265 -KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWNA 318
             + + +  ++  RLL+  R+    D         +    G  VL +L+ +     HW A
Sbjct: 314 EGISSLFSSLKVVRLLRLGRVARKLD---------HYLEYGAAVLVLLVCVFGLVAHWLA 364

Query: 319 CIYFAISKFIGFGT-------DSWVYP---NISIPEHGRLSRK-----------YIYSLY 357
           CI+++I  +            DSW+Y    +I  P     S             Y+ SLY
Sbjct: 365 CIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLY 424

Query: 358 WSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 416
           ++  +LTTIG     P  D E +F V   +VG L++ATI GNV ++   M A+   +   
Sbjct: 425 FTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEM 484

Query: 417 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 476
           +++++ +++  +V K L  RV+ +    W+  K +D ++VL   P  ++A+I ++++   
Sbjct: 485 LNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKV 544

Query: 477 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGV 535
             +   F+    G L  L ++ +    +PGD I   G+    +  +  G L V+ DD V
Sbjct: 545 FNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEV 603


>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
           isoform 2 [Homo sapiens]
          Length = 732

 Score = 93.2 bits (230), Expect = 7e-19
 Identities = 70/276 (25%), Positives = 132/276 (47%), Gaps = 25/276 (9%)

Query: 205 VLDYSADVLYVLDVLVRARTGFLEQGL-MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 263
           V+D   D+++++D+L+  RT ++ Q   +VSD  ++  HY     F +D+++ +P DL  
Sbjct: 446 VVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHY-FKGWFLIDMVAAIPFDLLI 504

Query: 264 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 318
              G++        LLK +RL            Y      G  VL +L     +I HW A
Sbjct: 505 FGSGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLMLLMCIFALIAHWLA 560

Query: 319 CIYFAISKFIG-FGTDS--WV----------YPNISIPEHGRLSRKYIYSLYWSTLTLTT 365
           CI++AI      + TD   W+          Y +        +  KY+ +LY++  +LT+
Sbjct: 561 CIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTS 620

Query: 366 IG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYM 424
           +G     P  + E +F +   L+G L++A+I GNV ++I  + +  A +  ++  +K+++
Sbjct: 621 VGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFI 680

Query: 425 QFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSL 460
           +F ++   L  R+  +F + W     +D   V  S+
Sbjct: 681 RFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVCMSV 716


>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
           sapiens]
          Length = 671

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 30/100 (30%), Positives = 50/100 (50%), Gaps = 10/100 (10%)

Query: 473 HLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVAD 532
           +++ LK V  FQ     +L +L   L  T +  G+YI ++G  G   +II++G + V  +
Sbjct: 212 YMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTRE 271

Query: 533 DGVTQFVV----LSDGSYFGEISILNIKGSKSGNRRTANI 568
           D  ++  V    L  G +FGE      K  +  + RTAN+
Sbjct: 272 DSPSEDPVFLRTLGKGDWFGE------KALQGEDVRTANV 305



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 28/123 (22%), Positives = 56/123 (45%), Gaps = 16/123 (13%)

Query: 484 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 543
           ++ E   + E+V  + P  +     I K+GD+G  +Y++ +GK+ V  +    +   +  
Sbjct: 105 KNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEG--VKLCTMGP 162

Query: 544 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEAL--------TEYPEAK 595
           G  FGE++IL          RTA ++++    L+ + +      +        TEY E  
Sbjct: 163 GKVFGELAIL------YNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFL 216

Query: 596 KAL 598
           K++
Sbjct: 217 KSV 219


>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
           sapiens]
          Length = 686

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 30/100 (30%), Positives = 50/100 (50%), Gaps = 10/100 (10%)

Query: 473 HLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVAD 532
           +++ LK V  FQ     +L +L   L  T +  G+YI ++G  G   +II++G + V  +
Sbjct: 227 YMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTRE 286

Query: 533 DGVTQFVV----LSDGSYFGEISILNIKGSKSGNRRTANI 568
           D  ++  V    L  G +FGE      K  +  + RTAN+
Sbjct: 287 DSPSEDPVFLRTLGKGDWFGE------KALQGEDVRTANV 320



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 28/123 (22%), Positives = 56/123 (45%), Gaps = 16/123 (13%)

Query: 484 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 543
           ++ E   + E+V  + P  +     I K+GD+G  +Y++ +GK+ V  +    +   +  
Sbjct: 120 KNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEG--VKLCTMGP 177

Query: 544 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEAL--------TEYPEAK 595
           G  FGE++IL          RTA ++++    L+ + +      +        TEY E  
Sbjct: 178 GKVFGELAIL------YNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFL 231

Query: 596 KAL 598
           K++
Sbjct: 232 KSV 234


>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
          Length = 762

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 33/129 (25%), Positives = 62/129 (48%), Gaps = 13/129 (10%)

Query: 477 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVV----AD 532
           L+ V + ++     L +++  L    +  GDYI ++G+ G   +I+ +GK+ V       
Sbjct: 281 LRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGH 340

Query: 533 DGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCL--SKDDLMEALTE 590
           D       L  G YFGE +++      S + R+ANI +   +D+ CL   ++   + +  
Sbjct: 341 DQPQLIKTLQKGEYFGEKALI------SDDVRSANIIA-EENDVACLVIDRETFNQTVGT 393

Query: 591 YPEAKKALE 599
           + E +K LE
Sbjct: 394 FEELQKYLE 402



 Score = 37.0 bits (84), Expect = 0.062
 Identities = 29/138 (21%), Positives = 65/138 (47%), Gaps = 11/138 (7%)

Query: 475 DTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDG 534
           D L K +  +  +   + ++V  +    +  G YI K+G+ G  ++++ EG+L V   + 
Sbjct: 161 DALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEK 220

Query: 535 VTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEA 594
           +   + +   + FGE++IL          RTA++++I     + L ++     +    +A
Sbjct: 221 LLSSIPM--WTTFGELAIL------YNCTRTASVKAITNVKTWALDREVFQNIMRRTAQA 272

Query: 595 KKALEEKGRQILMKDNLI 612
           +   +E+ R  L   +L+
Sbjct: 273 R---DEQYRNFLRSVSLL 287


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,738,609
Number of Sequences: 37866
Number of extensions: 1060320
Number of successful extensions: 4222
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 71
Number of HSP's that attempted gapping in prelim test: 3838
Number of HSP's gapped (non-prelim): 350
length of query: 694
length of database: 18,247,518
effective HSP length: 109
effective length of query: 585
effective length of database: 14,120,124
effective search space: 8260272540
effective search space used: 8260272540
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.